1 of 44 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D. C. 20460 OFFICE OF PREVENTION, PESTICIDES, AND TOXIC SUBSTANCES MEMORANDUM Date: November 23, 2005 Subject: Triadimefon. Summary of Analytical Chemistry and Residue Data for the Reregistration Eligibility Decision ( RED) Document.

DP Barcode: D314742 PC Code: 109901 40 CFR § : 180.410 Chemical Class: Triazole From: Samuel Ary, Chemist Reregistration Branch II Health Effects Division ( 7509C)

Through: Yvonne Barnes, Chemist Reregistration Branch II Health Effects Division ( 7509C)

Chemistry Science Advisory Council Health Effects Division ( 7509C)

William Hazel, Branch Chief Reregistration Branch II Health Effects Division ( 7509C)

To: Richard Griffin, Risk Assessor Reregistration Branch II Health Effects Division ( 7509C)

John Pates, Chemical Review Manager Reregistration Branch I Special Review and Reregistration Division ( 7508C) Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 2 of 44 Executive Summary Triadimefon, 1( 4 chlorophenoxy) 3,3 dimethyl 1( 1H 1,2,4 triazol 1 yl) 2 butanone, is a systemic fungicide used to control rust and mildew on apples, grapes, pears, pineapples, and raspberries. Triadimefon end use products are marketed in the United States under the trade name Bayleton ® and Summit ® . The reregistration of triadimefon is being supported by Bayer CropScience ( Bayer; formerly Miles, Inc. and Mobay Chemical Corporation), the basic producer. The Bayer triadimefon formulations registered for food/ feed uses include wettable powder ( WP) and flowable concentrate ( FlC) formulations.

Tolerances are established for residues of triadimefon and its metabolites containing chlorophenoxy and triazole moieties ( expressed as the parent compound) in/ on various plant and livestock commodities ( 40 CFR § 180.410). The established permanent tolerances for residues in plant and livestock commodities [ 40 CFR § 180.410( a)] range from 0.04 ppm ( milk, hog, and poultry commodities) to 145 ppm ( grass seed cleanings). A tolerance with regional registration is established for triadimefon and its metabolites in/ on raspberries at 2.0 ppm [ 40 CFR § 180.410( c)].

Residues of triadimenol [$( 4 chlorophenoxy)"( 1,1 dimethylethyl) 1H 1,2,4 triazole 1 ethanol] and its butanediol metabolite [ 1( 4 chlorophenoxy) 3,3 dimethyl 3 hydroxymethyl 1( 1H 1,2,4 triazol 1 yl) 2 butanol; KWG 1342], from use of triadimenol, are regulated separately under 40 CFR § 180.450. In addition, 40 CFR § 180.3( d)( 13) specifies that where tolerances are established for residues of both triadimefon and triadimenol including its butanediol metabolite, in or on the same raw agricultural commodity and its products thereof, the total amount of such residues shall not yield more residue than that permitted by the higher of the two tolerances. Currently, triadimefon and triadimenol do not share any uses, so 40 CFR § 180.3( d)( 13) should be deleted.

The reregistration requirements for plant metabolism are fulfilled based on adequate metabolism studies conducted with grapes, cucumbers, tomatoes, and wheat. On December 1, 1993 the Health Effects Division ( HED) Metabolism Assessment Review Committee ( MARC) concluded that for plants, the residues of concern consist of triadimefon, triadimenol, KWG 1323 [ 1( 4 chlorophenoxy) 3,3 dimethyl 3 hydroxymethyl 1( 1H 1,2,4 triazol 1 yl) 2 butanone], KWG 1342, and in cereal grains, triadimefon, triadimenol, KWG 1323, KWG 1342, and KWG 1732 [ 1 ( 4 chlorophenoxy) 1( 1H 1,2,4 triazol 1 yl) ethanoic acid] ( S. Knizner, HED MARC Memorandum, 1/ 3/ 1994). HED has revisited the MARC decision and determined that the triadimefon residues of concern in/ on apples, grapes, pears, pineapples, and raspberries for tolerance expression are triadimefon and triadimenol and for risk assessment are triadimefon, triadimenol, KWG 1323, and KWG 1342.

Additionally, the Agency does have concern about the potential toxicity of 1,2,4 triazole and two conjugates, triazole alanine and triazole acetic acid, which are metabolites common to most of the triazole fungicides. To support the extension of existing and granting of new parent triazolederivative fungicide tolerances, the Agency will be conducting a human health assessment for aggregate exposure to 1,2,4 triazole.

The reregistration requirements for livestock metabolism are fulfilled based on acceptable goat and poultry metabolism studies. HED has determined that the residues of concern for tolerance expression and risk assessment in livestock are triadimefon, triadimenol, KWG 1323, and KWG Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 3 of 44 1342.

If registration on additional commodities and livestock feed items are requested, then triazole and phenyl labeled plant and livestock metabolism studies would be required. Such data may, in turn, trigger the need for magnitude of the residue studies conducted with plants and livestock.

Two gas chromatography with mass spectrometry detection ( GC/ MS) methods are listed in PAM Vol. II for enforcement of tolerances for plant and livestock commodities. The methods use a single moiety detection in which residues are converted to p dichlorophenol, derivatized with dinitrofluorobenzene, and reported as triadimefon equivalents. The GC/ MS method is no longer adequate due to the recommended tolerance expression revisions. However, a GC method using a nitrogen phosphorus detector ( NPD; Report No. 80488) is available for determination of residues of triadimefon, triadimenol, KWG 1323, and KWG 1342 and is adequate for the enforcement of apple, grape, pear, pineapple, and raspberry tolerances. The reported method limit of quantitation ( LOQ) is 0.01 ppm for each analyte. The limit of detection ( LOD) was not reported.

The reregistration requirements for multiresidue method testing for residues of triadimefon and its metabolites are satisfied. The 10/ 99 FDA PESTDATA database ( PAM Volume I, Appendix I) indicates that triadimefon is completely recovered (> 80%) using Multiresidue Methods Section 302 ( Luke Method; Protocol D). Triadimenol is completely recovered using Section 302.

The reregistration requirements for storage stability data are satisfied. Adequate storage stability data for plant and livestock commodities have been submitted and evaluated.

The reregistration requirements for magnitude of the residue in/ on the following raw agricultural commodities ( RACs) based on the currently registered use patterns are fulfilled pending label revisions and/ or tolerance adjustments: apples, grapes, pears, pineapples, and raspberries.

The reregistration requirements for data depicting the magnitude of triadimefon residues of concern in meat, milk, poultry, and eggs have been fulfilled. Acceptable ruminant and poultry feeding studies have been submitted and evaluated. Triadimefon is not registered for use as a direct livestock treatment. HED concludes that the supported registered uses on apples, grapes, pears, pineapples, and raspberries result in a 40 CFR § 180.6( a)( 3) situation for ruminant commodities; i. e., there is no reasonable expectation of finite residues in ruminant commodities. Therefore, additional data on the transfer of residues to meat, milk, poultry, and eggs are not required and all tolerances for livestock commodities should be revoked. If registration on additional livestock feed items are requested, livestock tolerances may need to be reinstated.

A general summary of residue chemistry deficiencies are listed below; details of data requirements are listed in Table 5.

Regulatory Recommendations and Residue Chemistry Deficiencies ° Cucurbit uses should be removed from all labels and the registrant should submit recent copies of product labels showing the uses have been removed. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 4 of 44 Cl O N N N O ° Product labels ( EPA Reg. Nos. 264 737 and 432 1294) must be modified to specify that aerial applications to orchard crops be made in a minimum of 10 gal/ A. Alternatively, the registrant may submit crop field trial data for orchard crops reflecting application in 5 gal/ A using aerial equipment.

° The product labels for all triadimefon formulations should be modified to remove the rotational crop restrictions.

° The pineapple field trial data submitted did not indicate whether the dipping solutions were newly prepared each day or prepared once and then reused for subsequent dips. This is a deficiency and the registrant must state if dipping solutions were prepared fresh each day or prepared once and reused.

Background The Triadimefon Phase 4 Review dated 1/ 31/ 1991 by S. Funk and the subsequent Triadimefon Data Call In ( DCI) Notice dated 4/ 29/ 1992 summarized the status of available residue chemistry data for the reregistration of triadimefon. The Phase 4 Review identified several data deficiencies including plant and livestock metabolism, residue analytical methods, storage stability, and magnitude of the residue in plants. Several studies have been submitted and evaluated in response to the Triadimefon DCI. This document presents an overall and up to date Residue Chemistry Science Assessment with respect to the reregistration of triadimefon. The PC Code and nomenclature of triadimefon are listed below in Table 1 and the physicochemical properties are listed in Table 2. The structure of triadimefon and metabolites of concern are presented in Table 3.

Table 1. Triadimefon Nomenclature.

Chemical structure Common name Triadimefon Molecular formula C14H16ClN3O2 IUPAC name ( RS) 1( 4 chlorophenoxy) 3,3 dimethyl 1( 1H 1,2,4 triazol 1 yl) butan 2 one CAS name 1( 4 chlorophenoxy) 3,3 dimethyl 1( 1H 1,2,4 triazol 1 yl) 2 butanone CAS number 43121 43 3 PC Code 109901 Current food/ feed site registration apple, grape, pear, pineapple, and raspberry Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 5 of 44 Cl O N N N O Cl O N N N OH Cl O N N N O OH Table 2. Physicochemical Properties of Triadimefon Parameter Value Reference Molecular weight 293.75 g/ mol Merck Index 12th Edition Melting point/ range 82.3 ° C MRID 41616001 pH 5.5 in a 1% suspension compared to water MRID 41616001 Density at 20 ° C 1.23 g/ mL MRID 41616001 Water solubility at 20 ° C 64 mg/ L MRID 41616001 Solvent solubility at 25 ° C Moderately soluble in most organic solvents except aliphatics MRID 41616001 Vapor pressure 0.2 mPa at 20 ° C MRID 42307801 0.6 mPa at 25 ° C Octanol/ water partition coefficient log Po/ w of 3.11 at 22 ° C MRID 42307801 Table 3. Chemical Names and Structures of Triadimefon and Its Metabolites.

Common name and chemical name Chemical structure Triadimefon 1( 4 chlorophenoxy) 3,3 dimethyl 1( 1H 1,2,4 triazol 1 yl) 2 butanone Triadimenol ( KWG 0519)

$( 4 chlorophenoxy)"( 1,1 dimethylethyl) 1H 1,2,4 triazole 1 ethanol KWG 1323 1( 4 chlorophenoxy) 3,3 dimethyl 3 hydroxymethyl 1( 1H 1,2,4 triazol 1 yl) 2 butanone Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 Table 3. Chemical Names and Structures of Triadimefon and Its Metabolites.

Common name and chemical name Chemical structure 6 of 44 Cl O N N N OH OH Cl O N N N O OH KWG 1342 1( 4 chlorophenoxy) 3,3 dimethyl 3 hydroxymethyl 1( 1H 1,2,4 triazol 1 yl) 2 butanol KWG 1732 1( 4 chlorophenoxy) 1( 1H 1,2,4 triazol 1 yl) ethanoic acid Summary of Science Findings 860.1200 Directions for Use Product List There is one Bayer CropScience and two Bayer Environmental Science end use products containing the active ingredient triadimefon which are registered for use on domestically grown food/ feed crops as indicated in Table 4. In addition, there is one SLN registration ( HI030004) for use of triadimefon on pineapple.

Table 4. Triadimefon End use Products ( EPs) Registered by Bayer CropScience.

EPA Reg. No. Formulation Registrant Product Name 264 7372 50% WP1 Bayer CropScience Bayleton ® 50% Wettable Powder Fungicide 432 1293 25% WP1 Bayer Environmental Science Bayleton ® 25% Wettable Powder Fungicide 432 1294 50% WP1 Bayer Environmental Science Bayleton ® 50% Wettable Powder Fungicide In Water Soluble Packets 1. WP= Wettable Powder and FlC= Flowable Concentrate. 2. Including SLN No. HI030004 for application of triadimefon to pineapple in Hawaii.

Use Pattern Table A comprehensive summary of triadimefon food/ feed use patterns based on the product labels registered to Bayer, was prepared by the Biological and Economic Analysis Division ( BEAD; dated 5/ 9/ 2005) and is presented in Appendix 1. A tabular summary of the residue chemistry science assessments for reregistration of triadimefon is presented in Table 5. The conclusions Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 7 of 44 listed in Table 5 regarding the reregistration eligibility of triadimefon food/ feed uses are based on the use patterns being supported by the basic producer, Bayer. When end use product data call in's ( DCIs) are developed ( e. g., at issuance of the RED), the Registration Division ( RD) should require that all end use product labels ( e. g., MAI labels, special local needs ( SLNs), and products subject to the generic data exemption) be amended such that they are consistent with labels registered to Bayer.

The basic producer has requested the deletion of certain uses from product labels which have not yet been removed. For the 25% WP formulation ( EPA Reg. No. 432 1293), Bayer requested that uses on cucurbits be removed ( 62 R 30578, 6/ 24/ 97). Uses on cucurbits still remain on the product label for the 25% WP formulation. For the purpose of generating this chemistry summary document, it was assumed that these uses will be removed from product labels. The registrant should submit recent copies of the product labels for the 25% WP formulations.

The product labels for the 50% WP formulations ( EPA Reg. Nos. 264 737 and 432 1294) must be modified to specify that aerial applications to orchard crops be made in a minimum of 10 gal/ A. Alternatively, the registrant may submit crop field trial data for orchard crops reflecting application in 5 gal/ A using aerial equipment.

The product labels for all triadimefon formulations should be modified to remove the rotational crop restrictions. The basic producer is not supporting use of triadimefon on any rotatable crops.

Table 5. Residue Chemistry Science Assessment for the Reregistration of Triadimefon.

GLN Data Requirements Current Tolerances, ppm [ 40 CFR] Must Additional Data Be Submitted? References1 860.1200 Directions for Use Not applicable ( N/ A) Yes2 See Appendix 1 860.1300 Plant Metabolism N/ A No 42123401 421234033, 427989014, 428534015,6, 92188025 92188033 860.1300 Livestock Metabolism N/ A No 421234043, 428568016,7, 428649016,8, 43418301 434183029, 92188034 92188039 860.1340 Residue Analytical Methods Plant commodities N/ A No 4387010111, 4404100211, 92188040 92188043 Livestock commodities N/ A No13 434183039, 92188044 92188048 860.1360 Multiresidue Methods N/ A No 4197660114, 4370540115 860.1380 Storage Stability Data Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 Table 5. Residue Chemistry Science Assessment for the Reregistration of Triadimefon.

GLN Data Requirements Current Tolerances, ppm [ 40 CFR] Must Additional Data Be Submitted? References1 8 of 44 Plant/ processed commodities N/ A No 4197660216, 4285740117, 4403890111, 4404100111, 92188051 92188053 Livestock commodities N/ A No 4346240118 860.1400 Water, Fish, and Irrigated Crops N/ A N/ A 860.1460 Food Handling N/ A N/ A 860.1480 Meat, Milk, Poultry, and Eggs Milk and the Fat, Meat, and Meat Byproducts of Cattle, Goats, Hogs, Horses, and Sheep 0.04, milk; 0.04, fat, meat and mbyp of hogs; 1.0, fat, meat, and mbyp of cattle, goats, horses, and sheep [ § 180.410( a)] No 92188054, 92188055 Eggs and the Fat, Meat, and Meat Byproducts of Poultry 0.04, eggs, fat, meat, and mbyp [ § 180.410( a)] No 92188056, 92188057 860.1500 Crop Field Trials Root and Tuber Vegetables Group Beet, sugar 0.5 [ § 180.410( a)] No19 92188063, 92188065, 92188069, 92188073 Leaves of Root and Tuber Vegetables Group Beet, sugar, tops 3.0 [ § 180.410( a)] No19 92188063, 92188073 Legume Vegetables Group Chickpea, dry 0.1 [ § 180.410( a)] No20 92188060, 92188070 Cucurbit Vegetables Group Cucumbers 0.3 [ § 180.410( a)] No2 42342305 23 Melons No2 4234230423 Summer squash No2 4234230823 Pome Fruits Group Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 Table 5. Residue Chemistry Science Assessment for the Reregistration of Triadimefon.

GLN Data Requirements Current Tolerances, ppm [ 40 CFR] Must Additional Data Be Submitted? References1 9 of 44 Apple 1.0 [ § 180.410( a)] No 4234230323,24 Pear 1.0 [ § 180.410( a)] No 4234230623,24 Stone Fruits Group Nectarines 4.0 [ § 180.410( a)] No25 Berries Group Raspberries 2.0 [ § 180.410( c)] No 92188061 Cereal Grains Group Wheat, grain and aspirated grain fractions 1.0, grain [ § 180.410( a)] No26 92188064, 92188074 Fodder, Forage, Hay, and Straw of Cereal Grains Group Wheat, forage, hay, and straw 15.0, forage; 5.0, straw [ § 180.410( a)] No26 92188064, 92188074 Grass Forage, Fodder, and Hay Group Grass, seed screenings, forage, hay, and straw 0.2, forage; 145.0, seed screenings; 105.0, straw, grown for seed [ § 180.410( a)] No27 92188062, 92188075 Miscellaneous Commodities Grapes 1.0 [ § 180.410( a)] No 4180940123 Pineapple 3.0 [ § 180.410( a)] Yes31 4234230723 860.1520 Processed Food/ Feed Apple 4.0, wet and dry pomace [ § 180.410( a)] No 4234660124,10, 4394860129 Beet, sugar None established No19 92188065, 92188069 Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 Table 5. Residue Chemistry Science Assessment for the Reregistration of Triadimefon.

GLN Data Requirements Current Tolerances, ppm [ 40 CFR] Must Additional Data Be Submitted? References1 10 of 44 Grape 3.0, wet and dry pomace; 7.0, raisin waste [ § 180.410( a)] No 4328440128 Pineapple None established No 4201320121 Wheat 4.0, milled fractions ( except flour) [ § 180.410( a)] No26 92188064, 92188074 860.1650 Submittal of Analytical Reference Standards N/ A Yes30 860.1850 Confined Rotational Crops N/ A No 426133016,22 860.1900 Field Rotational Crops None established No12 1. Bolded references were evaluated in the Triadimefon Phase 4 Review dated 1/ 31/ 91, by S. Funk. All other references were reviewed as noted.

2. Bayer has requested the deletion of certain uses from product labels which have not yet been removed. For the 25% WP formulation ( EPA Reg. No. 432 1293), Bayer requested that uses on cucurbits be removed ( 62 R 30578, 6/ 24/ 97). Uses on cucurbits still remain on the product label for the 25% WP formulation. For the purpose of generating this chemistry summary document, it was assumed that these uses will be removed from product labels. The registrant should submit recent copies of the product labels for the 25% WP formulations.

The product labels for the 50% WP formulations ( EPA Reg. Nos. 264 737 and 432 1294) must be modified to specify that aerial applications to orchard crops be made in a minimum of 10 gal/ A. Alternatively, the registrant may submit crop field trial data for orchard crops reflecting application in 5 gal/ A using aerial equipment.

Assuming that uses on cucurbits are removed from the 25% WP formulation, the product labels for all triadimefon formulations should be modified to remove the rotational crop restrictions. The basic producer is not supporting use of triadimefon on any rotatable crops.

3. C. Swartz, D174151, 9/ 23/ 92.

4. C. Swartz, D194719, 10/ 20/ 93.

5. S. Knizner, D194676, 11/ 3/ 93.

6. S. Knizner, Memorandum, no DP Barcode, 12/ 9/ 93.

7. S. Knizner, D194819, 11/ 2/ 93.

8. S. Knizner, D194786, 11/ 2/ 93.

9. S. Knizner, D208890, 12/ 16/ 94.

10. S. Funk, D179962, 7/ 24/ 92. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 11 of 44 11. J. Punzi, D222403, D227497, and D227543, MRID 44038901,43870101, and 44041002, 7/ 13/ 00.

12. Based on the results of the confined rotational crop study, limited and/ or extensive field rotational crop studies were required. However, the registrant has since requested removal of all rotatable crop uses from product labels. If uses on cucurbits and sugar beets have been removed from product labels, no additional data pertaining to confined/ field accumulation in rotational crops will be required.

13. Additional data on livestock residue analytical methods are not required if all tolerances for livestock commodities are revoked.

14. Forwarded to FDA for inclusion in PAM Vol. I ( L. Edwards memo of 6/ 30/ 92).

15. Forwarded to FDA for inclusion in PAM Vol. I.

16. S. Hummel, D168542 and D178884, 12/ 22/ 92.

17. S. Knizner, D194783, 11/ 17/ 93.

18. S. Knizner, D210160, 2/ 23/ 95.

19. Bayer does not currently have any registered uses of triadimefon on sugar beats.

20. Bayer does not currently have any registered uses of triadimefon on chickpea plants.

21. F. Toghrol, D175489, 9/ 18/ 92; Amended Registrations Team, D209623 and D209629, 2/ 21/ 95.

22. S. Knizner, D186937, 11/ 3/ 93.

23. S. Knizner, D179335, D181031, and D181032, 12/ 10/ 92.

24. Data in this MRID were evaluated in conjunction with a petition ( PP# 3E4164) to establish a crop group tolerance for pome fruits ( D. Davis, D183726, 2/ 13/ 93).

25. The Phase 4 Review noted that the registered uses on stone fruits had been removed from product labels. There are currently no registered uses of triadimefon on nectarines on Bayer product labels; the established tolerance should be revoked.

26. Bayer does not currently have any registered uses of triadimefon on wheat.

27. Bayer does not currently have any registered uses of triadimefon on pasture, rangeland, or grass grown for seed.

28. S. Knizner, D205423, 2/ 23/ 95.

29. S. Ary, D321636, MRID 43948601, 8/ 31/ 05.

30. Analytical reference standards must be replenished as requested by the Repository.

31. The pineapple field trial data submitted did not indicate whether the dipping solutions were newly prepared each day or prepared once and then reused for subsequent dips. This is a deficiency and the registrant must state if dipping solutions were prepared fresh each day or prepared once and reused. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 12 of 44 860.1300 Nature of the Residue  Plants The reregistration requirements for plant metabolism are fulfilled based on adequate metabolism studies conducted with grapes, cucumbers, tomatoes, and wheat.

Apple ( MRID 42123402)

The Mobay study depicting metabolism of 3,5 C triazol ring and uniformly, phenyl ring labeled [ 14C] triadimefon in apples was found to be deficient, due to the fact that metabolite identifications made using TLC were not confirmed. The Phase 4 review ( S. Funk, 1/ 31/ 91) data gap for Guideline Number ( GLN) 860.1300 cited the lack of raw data and sample chromatograms supporting the apple metabolism study as deficiencies.

The additional supporting data submitted by the registrant ( MRID 42123402) included raw data ( i. e. sample weights and ppm data), as well as one set of thin layer chromatography ( TLC) chromatograms for the benzene wash, and organosoluble fractions from the peel and pulp. The raw data support the values reported in Tables I through VII of the original submission, with a few minor corrections. The sample TLC is difficult to read, and locations of the unidentified metabolite were not clearly labeled. In addition, there were no data submitted for confirmation of the TLC results, i. e. high performance liquid chromatography ( HPLC) or GC/ MS. Consequently, the additional submission has not rendered the study acceptable. The need for an additional apple metabolism study has been waived after reevaluation of the cucumber, tomato, grape, and wheat metabolism studies. However, if confirmatory GC/ MS or MS spectra, or HPLC chromatograms confirming metabolite identities are available, they should be submitted to the Agency for review. If the registrant intends to conduct an additional apple metabolism study, HED strongly recommends that application of the radiolabeled formulation include foliar contact.

Cucumber and Tomato ( MRID 42123401)

In the cucumber and tomato metabolism studies, seedlings were treated with [ phenyl 14C] triadimefon at approximately 1x the maximum rate for cucumbers. Selected plants were treated two additional times, beginning at fruit set. Metabolism of triadimefon in tomato and cucumber seedlings receiving a single foliar application appears to consist of rapid degradation of the parent, concomitant with an increase in triadimenol. Hydrolysis of water soluble radiocarbon and foliage samples from cucumber seedlings released triadimefon and triadimenol, as well as low levels of KWG 1323 and KWG 1342. These additional metabolites were not detected in the tomato seedlings. Degradation of triadimefon in mature cucumber and tomato plants appeared to be similar to that in the seedlings, with minor differences. The fruit and foliage differed in their ability to metabolize the parent. In both tomato and cucumber fruit, the terminal degradation product was primarily triadimenol, while the foliage of both tomato and cucumber exhibited a more complex series of degradation products. In tomato, triadimefon and triadimenol account for 96.6% total radioactive residue ( TRR) one day after treatment, 88.1% TRR 7 days after treatment, 83.8% TRR 14 days after treatment, 80.0% TRR 21 days after treatment, and 75.7% TRR 28 days after treatment. Similar results were reported for cucumber. KWG 1732 was not identified in either tomatoes or cucumbers. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 13 of 44 Grape ( MRID 42123403)

In a grape metabolism study, mature fruit were harvested 56 days following treatment of an established vine with [ phenyl 14C] triadimefon; immature fruit were harvested at various earlier intervals. A rapid decline in total radioactivity was observed, due to the volatility of triadimefon. The decline in the quantity of parent observed was accompanied by a buildup of the metabolite triadimenol. Triadimenol accounted for 55.6% of TRR in mature grapes while triadimefon was only detected at 1.1% TRR. The remainder of the identified radioactivity was comprised of KWG 1342 and its conjugates ( 15.5% TRR), triadimenol conjugates ( 5.6% TRR), and p chlorophenol and its conjugates ( 6.2% TRR). KWG 1323 and KWG 1732 were not identified in the study.

Wheat ( MRID 42853401)

Following foliar treatment of wheat with [ phenyl 14C] triadimefon at a rate of 236 g ai/ A, approximately 2x the maximum registered rate for wheat, the metabolite KWG 1732 was the major residue identified ( 35% TRR) in wheat grain; a glucoside of KWG 1342 was the other major residue identified ( 21% TRR) in wheat grain. Additionally, triadimefon accounted for 1% TRR, triadimenol accounted for 6% TRR and its glucoside was found at 6% TRR; pchlorophenol was also identified at 5% TRR. In wheat forage, triadimefon was found at 31 74% TRR and triadimenol was found at 12 35% TRR; together they accounted for the majority of residues ( 66 86% TRR); p chlorophenol and its glucoside were also identified, at 9 16% TRR. In wheat straw, triadimenol and its conjugates accounted for the majority of the radioactivity at 53% TRR and triadimefon accounted for only 1% TRR; p chlorophenol and its conjugates and KWG 1342 and its conjugates were also identified, at 21% and 19% TRR, respectively.

The HED MARC examined the results of these studies and determined that the residues of concern in plants are triadimefon, triadimenol, KWG 1323, KWG 1342, and, in cereal grains, triadimefon, triadimenol, KWG 1323, KWG 1342, and KWG 1732 ( S. Knizner, HED MARC memorandum, 1/ 3/ 1994). The chemical names and structures of these compounds are presented in Table 3.

The reregistration requirements for plant metabolism have been fulfilled. HED has revisited the MARC decision by examining all the available metabolism and field trial data and determined that the triadimefon residues of concern in/ on apples, grapes, pears, pineapples, and raspberries for tolerance expression are triadimefon and triadimenol and for risk assessment are triadimefon, triadimenol, KWG 1323, and KWG 1342. The metabolism study conducted with triadimefon applied to grapes indicate that triadimenol is the major metabolite identified at 56% along with KWG 1342 at 16%. Triadimefon accounted for 1.1% TRR. The available field trial data indicate that residues of triadimefon and triadimenol are likely to be found in/ on apples, grapes, pears, pineapples, and raspberries and will be good indicators of misuse for tolerance enforcement. The two metabolites, KWG 1323 and KWG 1342 were mostly non quantifiable as indicated from the field trial data and therefore should only be included in risk assessment.

There have been no previous triazole labeled studies conducted with triadimefon and data from the available soil metabolism studies conducted with triadimefon indicate that soil microbes metabolize the triazole fungicide to free triazole, which may be taken up into the plant. If registration on additional commodities and livestock feed items are requested, then triazole and Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 14 of 44 phenyl labeled plant and livestock metabolism studies would be required. Such data may, in turn, trigger the need for magnitude of the residue studies conducted with plants and livestock.

860.1300 Nature of the Residue  Livestock The reregistration requirements for livestock metabolism are fulfilled based on acceptable goat and poultry metabolism studies. For the ruminant study, a lactating goat received [ phenyl 14C] triadimefon at 86.4 ppm for three consecutive days in feed. The feeding level corresponds to 1728x the maximum theoretical dietary burden to dairy cattle and 864x the maximum theoretical dietary burden to beef cattle ( see 860.1480 Meat, Milk, Poultry, and Eggs). The parent was detected at low levels in milk and fat (< 5% TRR) but was not detected in kidney, liver, or muscle. The major residue identified was KWG 1342 glucuronide ( 6 47% TRR). Triadimenol and its conjugates comprised a major portion of the residue in tissues and milk ( totals of 9 42% TRR). The remainder of the radioactivity was identified as KWG 1323 glucuronide ( 19 22% TRR in muscle and fat) and KWG 1342 ( 1 6% TRR) and its sulfate ( 1 15% TRR in tissues, 43% TRR in milk).

For the poultry study, 16 laying hens received [ phenyl 14C] triadimefon at 28.7 ppm for three consecutive days in feed. The parent was identified in fat and eggs ( 4 17% TRR) but was not detected in liver or muscle. Triadimenol and its related compounds were the major metabolites identified ( totals of 41 49% TRR). The remainder of the radioactivity was identified as KWG 1342 and its related compounds ( totals of 10 36% TRR), p chlorophenol ( liver and fat only at 2 4% TRR), chlorophenoxytriazolyl acetic acid ( muscle only at 3% TRR), and KWG 1323 ( fat and eggs only at 3 5% TRR). Currently, the basic producer ( Bayer) does not have any registered uses of triadimefon on poultry feed items.

HED has determined that the residues of concern for tolerance expression and risk assessment in livestock are triadimefon, triadimenol, KWG 1323, and KWG 1342. The chemical names and structures of these compounds are presented in Table 3.

860.1340 Residue Analytical Methods  Plants The Pesticide Analytical Manual ( PAM) Vol. II lists two GC/ MS methods ( Methods I and II) for the determination of triadimefon and its free and conjugated metabolites in plant commodities. Both methods are common moiety methods. In Method I ( Report No. 69531), residues are extracted using methanol or methanol: acetone ( 2: 1, v: v). Following cleanup on an ion exchange column, the total residues are hydrolyzed to p chlorophenol using concentrated HCl. p Chlorophenol is isolated by steam distillation followed by acid/ base partitioning and then derivatized with dinitrofluorobenzene for determination by GC/ MS using selected ion monitoring. Residues are expressed in triadimefon equivalents. Method II ( Report No. 80265) is similar to Method I. The reported LOQ is 0.05 and LOD is 0.01 ppm for both methods.

A GC/ NPD method ( Report No. 80488) is available for determination of residues of triadimefon, triadimenol, KWG 1342, and KWG 1323 and is adequate for the enforcement of apple, grape, pear, pineapple, and raspberry tolerances. Briefly, residues are extracted under reflux in methanol: water ( 7: 3, v: v) and the extract is buffered and hydrolyzed in cellulase at 37 ° C overnight to release conjugated residues. Residues are partitioned into dichloromethane: acetonitrile ( 2: 1, Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 15 of 44 v: v), cleaned up by gel permeation chromatography, and separated into parent ( triadimefon and triadimenol) and metabolite ( KWG 1342 and KWG 1323) fractions by semi preparative HPLC. The metabolite fraction residues are derivatized with trifluoroacetic anhydride and all residues are determined using GC/ NPD. The reported LOQ for apples, cucurbits, grapes, pears, and pineapple is 0.01 ppm for triadimefon, triadimenol, KWG 1342, and KWG 1323. The LOD was not reported.

The registrant has proposed a GC/ MS method ( Report No. 106549) for enforcement of tolerances for residues of triadimefon, triadimenol, KWG 1342, KWG 1323, and KWG 1732 in plant commodities. Briefly, residues are extracted under reflux in methanol: water, hydrolyzed with cellulase at 37 ° C overnight, and partitioned with dichloromethane: acetonitrile. The aqueous phase, containing KWG 1732, is partitioned with acidic ethyl acetate, and methylated with trimethylsilyl diazomethane for analysis by GC/ MS. The dichloromethane phase is cleaned up by gel permeation chromatography and separated by semi preparative HPLC into two fractions: one containing triadimefon and triadimenol and the other containing KWG 1323 and KWG 1342. Triadimefon and triadimenol are determined directly by GC/ MS; KWG 1323 and KWG 1342 are derivatized prior to GC/ MS analysis. The method has been successfully radiovalidated and has undergone independent laboratory validation. The reported method LOQ is 0.05 ppm for triadimefon, triadimenol, KWG 1342, KWG 1323, and KWG 1732 in wheat grain. The LOD was not reported.

860.1340 Residue Analytical Methods  Livestock The Pesticide Analytical Manual ( PAM) Vol. II lists the two GC/ MS methods described above ( Methods I and II) for the determination of triadimefon and its free and conjugated metabolites in livestock commodities. Method I ( Report No. 69531) is appropriate for livestock tissues and milk and Method II ( Report No. 80265) is appropriate for livestock tissues and eggs. The reported LOQ is 0.05 and LOD is 0.01 ppm for both methods.

860.1360 Multiresidue Methods The reregistration requirements for multiresidue method testing for residues of triadimefon and its metabolites are satisfied. The 10/ 99 FDA PESTDATA database ( PAM Volume I, Appendix I) indicates that triadimefon is completely recovered (> 80%) using Multiresidue Methods Section 302 ( Luke Method; Protocol D); recovery of triadimefon is small (< 50%) using Multiresidue Methods Sections 303 ( Mills, Onley, and Gaither; Protocol E, nonfatty) and 304 ( Mills, fatty food). Triadimefon metabolites triadimenol and KWG 1323 are completely recovered using Section 302. Triadimenol, KWG 1323, and KWG 1732 are not recovered using Sections 303 and 304. Although multiresidue method testing data have been submitted for KWG 1342, the PESTDATA database does not contain any recovery data for this metabolite.

860.1380 Storage Stability Data The reregistration requirements for storage stability data are satisfied. Adequate storage stability data for plant and livestock commodities have been submitted and evaluated.

Plant commodities: The available storage stability data indicate that residues of triadimefon and Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 16 of 44 its metabolites triadimenol, KWG 1342, and KWG 1323 are stable for up to 24 months of frozen storage ( ca.  20 ° C) in/ on the following commodities: apple; cucumber; grapes, grape juice, and raisins; pineapple; sugar beet roots, tops, and molasses; tomatoes; and wheat grain and forage. These analytes are also stable in grape pomace ( wet and dry) for up to 6 months. Residues of triadimefon and KWG 1323 are stable in asparagus and wheat straw, bran, flour and grain dust up to 24 months of frozen storage, and residues of triadimefon, triadimenol, and KWG 1323 are stable in coffee beans up to 6 months of frozen storage. When corrected for concurrent method recoveries, residues of triadimenol appear to decline after 24 months in the following crop matrices: asparagus ( 18%), wheat straw ( 30%), bran ( 29%), flour ( 25%), and grain dust ( 17%). Residues of KWG 1342 also appeared to decline in asparagus ( 15%) and wheat bran ( 20%) after 24 months of frozen storage, and in coffee beans ( 79%) after 40 days of storage.

Storage stability data indicate that KWG 1732 is stable in wheat grain stored frozen at approximately  20 ° C for up to 2.5 years.

Livestock commodities: The available storage stability data, collected using samples from the livestock metabolism studies, indicate that residues of triadimefon and its regulated metabolites are stable in goat milk, fat, and liver approximately 14, 26, and 29 months, respectively, of frozen storage. Residues were found to be stable in poultry muscle and eggs approximately 15 months of frozen storage. These data are adequate to validate the storage intervals of livestock commodity samples collected from the feeding studies.

860.1400 Water, Fish, and Irrigated Crops Triadimefon is not registered for direct use on water and aquatic food and feed crops. Therefore, no residue chemistry data are required under these guideline topics.

860.1460 Food Handling Triadimefon is not registered for use in food handling establishments; therefore, no residue chemistry data are required under this guideline topic.

860.1480 Meat, Milk, Poultry, and Eggs The reregistration requirements for data depicting the magnitude of triadimefon residues of concern in meat, milk, poultry, and eggs have been fulfilled. Acceptable ruminant and poultry feeding studies have been submitted and evaluated. In these studies, livestock were fed a 1: 1 mixture of triadimefon and triadimenol. Samples were analyzed for bound and free residues of triadimefon, triadimenol, KWG 1342, and KWG 1323.

The theoretical dietary burden ( TDB) to cattle is presented below in Table 6. Currently, the basic producer, Bayer, has no registered uses of triadimefon on any poultry or swine feed items. Therefore, no tolerances for poultry or swine commodities are required.

Table 6. Calculation of Dietary Burdens of Triadimefon to Livestock.

Feed Commodity % Dry Matter1 % Diet1 Reassessed Tolerance ( ppm) 2 Dietary Contribution ( ppm) 3 Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 Table 6. Calculation of Dietary Burdens of Triadimefon to Livestock.

17 of 44 Beef Cattle Alfalfa, hay 89 45 No tolerance N/ A Apple, wet pomace 40 20 0.2 0.10 Corn, field, grain 88 20 No tolerance N/ A Soybean, meal 92 15 No tolerance N/ A TOTAL BURDEN N/ A4 100 N/ A 0.10 Dairy Cattle Alfalfa, hay 89 45 No tolerance N/ A Apple, wet pomace 40 10 0.2 0.05 Corn, field, grain 88 30 No tolerance N/ A Soybean, meal 92 15 No tolerance N/ A TOTAL BURDEN N/ A 100 N/ A 0.05 1. OPPTS Guideline 860.1200, Table 1 ( August 1996). 2. Reassessed tolerances from Table 14. 3. Contribution = (% diet / % dry matter) x ( reassessed tolerance). 4. N/ A = Not applicable.

Ruminant. In the ruminant feeding study, cattle were fed triadimenol: triadimefon ( 1: 1) at total dose levels of 25, 75, and 250 ppm. The resulting triadimefon dose levels of 12.5, 37.5, and 125 ppm represent 125x, 375x, and 1250x the theoretical dietary burden to beef cattle, and 250x, 750x, and 2500x the TDB to dairy cattle. The results of the study are summarized in Table 7.

Table 7. Estimation of Potential Triadimefon, Triadimenol, KWG 1342, and KWG 1323 Residues in Milk and Tissues of Beef and Dairy Cows Using Data from the Ruminant Feeding Study.

Matrix 25 ppm feeding level ( 12.5 ppm triadimefon) 1 Estimated residues at 1x TDB using 25 ppm feeding level2 75 ppm feeding level ( 37.5 ppm triadimefon) 1 Estimated residues at 1x TDB using 75 ppm feeding level2 250 ppm feeding level ( 125 ppm triadimefon) 1 Estimated residues at 1x TDB using 250 ppm feeding level2 Milk 0.014 ( 0.007) 0.000028 0.035 ( 0.018) 0.000024 0.076 ( 0.038) 0.000015 Muscle < 0.01 0.000040 0.019 ( 0.009) 0.000024 0.043 ( 0.022) 0.000018 Kidney 0.412 ( 0.206) 0.0016 0.787 ( 0.394) 0.0011 2.27 ( 1.14) 0.00091 Liver 0.093 ( 0.047) 0.00038 0.287 ( 0.144) 0.00038 1.00 ( 0.50) 0.00040 Fat 0.024 ( 0.012) 0.000096 0.086 ( 0.043) 0.00011 0.211 ( 0.106) 0.000085 1. Numbers in parentheses refer to triadimefon residue levels and were used to calculate the estimated residues at 1x TDB. It is assumed that one half of the total residues found is due to triadimefon. 2. Estimated triadimefon residues = ( total dietary contribution, Table 6 / feeding level) x ( residue from feeding studies; residues reported at less than the LOD of 0.01, half the LOD was used). Whole milk was calculated using TDB from dairy cattle. Muscle, fat, liver, and kidney were calculated using TDB from beef cattle.

The maximum residue of triadimefon observed in any matrix in the ruminant feeding study was kidney at 0.412 ppm after dosing at an exaggerated feeding level of 25 ppm ( 12.5 ppm triadimefon) or 125x the beef cattle dietary burden. Based on the 125x dosing level for beef cattle, the maximum expected residues of triadimefon in kidney at a 1x level are 0.0016 ppm, which is less than the livestock method LOD of 0.01 ppm.

Triadimefon is not registered for use as a direct livestock treatment. The nature of the residue in Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 18 of 44 livestock is adequately defined for the current uses. HED concludes that the supported registered uses on apples, grapes, pears, pineapples, and raspberries result in a 40 CFR § 180.6( a)( 3) situation for livestock commodities; i. e., there is no reasonable expectation of finite residues in livestock commodities. Therefore, additional data on the transfer of residues to meat, milk, poultry, and eggs are not required and all tolerances for livestock commodities should be revoked.

860.1500 Crop Field Trials The reregistration requirements for magnitude of the residue in/ on the following RACs based on the currently registered use patterns are fulfilled pending label revisions and/ or tolerance adjustments: apples, grapes, pears, pineapple, and raspberries.

Use of triadimefon on cucurbits are no longer being supported by bayer, and therefore, must be removed from all triadimefon product labels.

Apple ( MRID 42342303)

A tolerance of 1.0 ppm has been established for the combined residues of triadimefon and its metabolites containing chlorophenoxy and triazole moieties ( expressed as parent) in/ on apples [ 40 CFR § 180.410( a)].

The registrant cited previously submitted residue data ( 1977 1980; MRIDs 00025544, 00025715, and 00063831) for apples and processed fractions, which reflect a zero day PHI and support the current tolerance of 1.0 ppm. The registrant has submitted data ( 1992; MRID 42342303) to reflect a 45 day PHI for triadimefon use on apples. A total of ten trials were conducted in Region 1 ( two trials; NY and PA at a total of 0.75 lb ai/ A for both sites), Region 2 ( one trial; NC at 0.75 lb ai/ A), Region 5 ( three trials; IN at 0.47 lb ai/ A, KS at 0.41 lb ai/ A, and MI at 0.56 lb ai/ A), Region 10 ( two trials; Fresno, CA at 0.47 lb ai/ A and Walnut Grove, CA at 0.75 lb ai/ A), and Region 11 ( two trials; Selah, WA at 0.075 lb ai/ A and Wenatchee, WA at 1.5 lbs ai/ A). The geographical representation is considered adequate for reregistration. Samples were harvested at 35 46 days following the last of three foliar spray applications of the 50% DF formulation using ground equipment. Samples were stored at # 10 ° C for up to 212 days prior to analysis using Method 80488. Residues found in/ on treated samples are summarized in Table 8; the combined residues of triadimefon and the three measured metabolites ( triadimenol, KWG 1342, and KWG 1323) were # 0.09 ppm in/ on all treated samples.

These data indicate that the established tolerance for apples is too high based on a 45 day PHI, and that the combined residues of parent and metabolites are not likely to exceed 0.2 ppm in/ on apples following application at the maximum registered rate of 0.75 lb ai/ A with a 45 day PHI.

Grapes ( MRID 41809401)

A tolerance of 1.0 ppm has been established for the combined residues of triadimefon and its metabolites containing chlorophenoxy and triazole moieties ( expressed as parent) in/ on grapes [ 40 CFR § 180.410( a)].

The registrant has submitted data ( 1991; MRID 41809401) for grapes, which indicate that the Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 19 of 44 combined residues of triadimefon, triadimenol, KWG 1342, and KWG 1323 are not likely to exceed the established tolerance of 1.0 ppm following a total application rate of 0.56 lb ai/ A and a 14 day PHI. A total of seven trials were conducted in Region 1 ( one trial, NY), Region 5 ( one trial, MI), Region 10 ( three trials, CA), and Region 11 ( two trials, OR and WA). The geographical representation is considered adequate for reregistration. Samples were harvested at 0, 7, 14, 21, and 28 days following the last of four foliar spray applications of the 50% DF formulation at 0.19 lb ai/ A/ application using ground equipment. A total of 0.75 lb ai/ A was applied in four treatments made at 14 day intervals. Samples were stored at # 10 ° C for up to 406 days prior to analysis using Method 80488. Residues found in/ on treated samples are summarized in Table 8; the combined residues of triadimefon and the measured metabolites were # 0.62 ppm in/ on all treated samples.

These data indicate that the combined residues of parent and metabolites are not likely to exceed the established tolerance of 1.0 ppm in/ on grapes following application at the maximum registered rate of 0.56 lb ai/ A with a 14 day PHI.

Pear ( MRID 42342306)

A tolerance of 1.0 ppm has been established for the combined residues of triadimefon and its metabolites containing chlorophenoxy and triazole moieties ( expressed as parent) in/ on pears [ 40 CFR § 180.410( a)].

The registrant cited previously submitted residue data ( MRID 00093967) for pears, which reflects a zero day PHI and support the current tolerance of 1.0 ppm. The registrant has submitted data ( 1992; MRID 42342306) to reflect a 45 day PHI for triadimefon use on pears. A total of six trials were conducted in Region 1 ( one trial, NY at a total of 0.75 lb ai/ A), Region 5 ( one trial, MI at 0.56 lb ai/ A), Region 10 ( two trials, Clarksburg, CA at 1.2 lbs ai/ A and Hollister, CA at 0.75 lb ai/ A), and Region 11 ( two trials, OR at 0.75 lb ai/ A and WA at 0.47 lb ai/ A). The geographical representation is considered adequate for reregistration. Samples were harvested at 45 46 days following the last of three foliar spray applications of the 50% DF formulation using ground equipment. Samples were stored at # 10 ° C for up to 230 days prior to analysis using Method 80488. Residues found in/ on treated samples are summarized in Table 8; the combined residues of triadimefon and the three measured metabolites were # 0.08 ppm in/ on all treated samples.

These data indicate that the established tolerance of 1.0 ppm for pears is to high based on a 45 day PHI, and that the combined residues of parent and metabolites in/ on pears are not likely to exceed 0.20 ppm following application at the maximum registered rate of 0.75 lb ai/ A with a 45 day PHI.

Pineapple ( MRID 42342307)

A tolerance of 3.0 ppm has been established for the combined residues of triadimefon and its metabolites containing chlorophenoxy and triazole moieties ( expressed as parent) in/ on pears [ 40 CFR § 180.410( a)].

The 50% DF formulation may be applied to fresh pineapple as a postharvest dip or spray at 0.28 lb ai/ 100 gal. The fruit should be thoroughly covered and allowed to drain. Dipping time is Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 20 of 44 limited to a maximum of three minutes. The registrant submitted data ( 1992; MRID 42342307) for pineapples harvested from two test sites in HI, depicting the magnitude of residues of triadimefon and its metabolites triadimenol, KWG 1323, and KWG 1323 in/ on fresh pulp and peel ( with totals calculated for whole fruit based on the percentage weight of pulp and peel for each sample). The geographical representation is considered adequate for reregistration. Fresh whole pineapples received a postharvest dip treatment in a 1 gal or 7.5 gal solution containing the 50% DF formulation at 0.42 lb ai/ 100 gal. The dip solution for both treated and untreated fruit also contained FMC Sta Fresh 7055 wax. Five samples from each of the two sites were dipped, one sample from each site per day over five consecutive days ( to approximate operator variation). It was not clear whether the dipping solutions were newly prepared each day or prepared once and then reused for subsequent dips. This is a deficiency and the registrant must state if dipping solutions were prepared fresh each day or prepared once and reused. If dipping solutions were reused, the registrant must either demonstrate the integrity of the dip solutions under these conditions, or perform a new study.

Eight samples were dipped for three minutes each, and two samples were dipped for thirty seconds each. Samples were frozen after dipping, and were stored at # 10 ° C for up to 239 days prior to analysis using Method 80488. Residues found in/ on treated samples are summarized in Table 8; the combined residues of triadimefon and the three measured metabolites were # 0.18 ppm in/ on treated pulp, were # 8.10 ppm in/ on treated peel, and were calculated to be # 1.82 ppm in/ on the whole fruit.

These data indicate that the established tolerance of 3.0 ppm for pineapples is too high, and that the combined residues of parent and metabolites in/ on are not likely to exceed 2.0 ppm in/ on fresh pineapple following a three minute postharvest dip in solution containing the 50% DF formulation at the maximum registered rate of 0.28 lb ai/ 100 gal solution.

Raspberry ( MRID 92188061)

A tolerance of 2.0 ppm with a regional registration restricted to California has been established for the combined residues of triadimefon and its metabolites containing chlorophenoxy and triazole moieties ( expressed as parent) in/ on raspberries [ 40 CFR § 180.410( c)].

The registrant has submitted data ( 1990; MRID 92188061) for raspberries, which indicate that the combined residues of triadimefon, triadimenol, KWG 1342, and KWG 1323 are not likely to exceed the established tolerance of 2.0 ppm following a total application rate of 0.88 lb ai/ A and a 1 day PHI. A total of fifteen trials were conducted in Region 10 ( CA). The geographical representation is considered adequate for reregistration. Samples were harvested at 0, 1, 2, and 3 days following the last of seven foliar spray applications of the 50% WP formulation at 0.13 lb ai/ A/ application ( 9 samples), 0.19 lb ai/ A/ application ( 2 samples), and 0.25 lb ai/ A/ application ( 5 samples). A total of 0.88 lb ai/ A, 1.3 lbs ai/ A, or 1.8 lbs ai/ A was applied in seven treatments made at 12 to 15 day intervals. All applications were applied in 200 gallons of water per acre. Samples were stored at # 20 ° C prior to analysis using Method 54166. Residues found in/ on treated samples are summarized in Table 8. The maximum residues found when triadimefon was applied at the maximum use rate of 0.88 lb ai/ A with a 1 day PHI were 1.58 ppm.

Analysis for residues of the metabolites KWG 1323 and KWG 1342 are not considered necessary Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 21 of 44 to support the tolerance. Residue studies show that the metabolites KWG 1323 and KWG 1342 represent a negligible amount of the total residues on other crops such as grapes. The negligible quantities of the metabolites along with triadimefon and triadimenol would not likely exceed the established tolerance.

These data indicate that the combined residues of parent and metabolites are not likely to exceed the established tolerance of 2.0 ppm in/ on raspberries following application at the maximum registered rate of 0.88 lb ai/ A with a 1 day PHI.

Table 8. Summary of Residues from the Crop Field Trials with Triadimefon.

Crop Matrix ( number of samples) Total Applic. Rate in lb ai/ A PHI ( days) Residues ( ppm) 1 Triadimefon Triadimenol KWG 1342 KWG 1323 Total Residue2 Apple ( registered use = 0.75 lb ai/ A total application rate, 45 day PHI) 5 Whole fruit ( 1) 0.41 ( 0.55x) 45 < 0.01 < 0.01 < 0.01 < 0.01 0.04 Whole fruit ( 2) 0.47 ( 0.63x) 45 < 0.01 < 0.01 0.02 < 0.01 < 0.01 0.04 0.05 Whole fruit ( 1) 0.56 ( 0.75x) 46 < 0.01 0.02 < 0.01 < 0.01 0.05 Whole fruit ( 5) 0.75 ( 1x) 38 46 < 0.01 0.02 0.01 0.05 < 0.01 < 0.01 0.01 0.04 0.09 Grape ( registerd use = 0.56 lb ai/ A total application rate, 14 day PHI)

Whole fruit ( 7) 0.75 ( 1.3x) 0, 7, 14, 21, and 28 0.02 0.29 < 0.01 0.45 < 0.01 0.02 < 0.01 0.03 0.05 0.62 Pear ( registered use = 0.75 lb ai/ A total application rate, 45 day PHI)

Whole fruit ( 1) 0.47 ( 0.63x) 45 < 0.01 < 0.01 < 0.01 < 0.01 0.04 Whole fruit ( 1) 0.56 ( 0.75x) 45 < 0.01 < 0.01 < 0.01 < 0.01 0.04 Whole fruit ( 3) 0.75 ( 1x) 45 46 < 0.01 0.03 0.02 0.03 < 0.01 0.02 < 0.01 0.06 0.08 Whole fruit ( 1) 1.2 ( 1.6x) 45 < 0.01 < 0.01 < 0.01 < 0.01 0.04 Pineapple ( registered use = 0.28 lb ai/ 100 gal total postharvest dip or spray)

Peel ( 10) 0.42 lb ai/ 100 gal ( 1.48x) N/ A3 4.46 7.59 0.24 0.49 < 0.01 < 0.01 4.78 8.10 Pulp ( 10) 0.42 lb ai/ 100 gal ( 1.48x) N/ A 0.06 0.15 < 0.01 0.01 < 0.01 < 0.01 0.09 0.18 Whole fruit ( 10) 0.42 lb ai/ 100 gal ( 1.48x) N/ A NC4 NC NC NC 0.82 1.82 Raspberry ( registered use = 0.88 lb ai/ A total application rate, 1 day PHI)

Whole fruit ( 2) 0.88 ( 1x) 0 1.50 1.64 0.330 0.371 NS6 NS 1.83 2.01 Whole fruit ( 2) 0.88 ( 1x) 1 1.04 1.14 0.443 0.454 NS NS 1.49 1.58 Whole fruit ( 2) 0.88 ( 1x) 2 0.665 0.750 0.433 0.495 NS NS 1.10 1.25 Whole fruit ( 1) 0.88 ( 1x) 2 1.01 0.630 NS NS 1.64 Whole fruit ( 2) 0.88 ( 1x) 3 0.286 0.348 0.490 0.495 NS NS 0.78 0.84 Whole fruit ( 2) 1.3 ( 1.5x) 3 0.298 0.448 0.382 0.535 NS NS 0.68 0.98 Whole fruit ( 2) 1.8 ( 2x) 0 1.75 2.17 0.433 0.705 NS NS 2.46 2.60 Whole fruit ( 2) 1.8 ( 2x) 1 1.07 1.27 0.555 0.565 NS NS 1.63 1.84 Whole fruit ( 1) 1.8 ( 2x) 2 0.78 0.665 NS NS 1.45 1. Values corrected for apparent residues found in/ on control samples and for concurrent method recoveries. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 22 of 44 2. Calculated to include values < 0.01 ppm as 0.01 ppm. 3. N/ A = Not applicable. 4. NC = Not calculated. 5. 10 trials were conducted, however, the Selah, WA trial conducted at 0.075 lb ai/ A was excluded due to the low application rate. 6. NS = Not sampled.

The available crop field trials reflecting use of registered formulations at 1x the maximum label rate showed finite residues of triadimefon and its metabolites triadimenol, KWG 1342, and KWG 1323 in/ on the RACs of all crops for which registration exists. Overall, adequate field trial data depicting triadimefon residues of concern following treatments according to the maximum registered use patterns of the representative formulations that are being supported have been submitted for the RACs listed above. Details of any required label amendments are presented in 860.1200 Directions for Use. Refer to the " Tolerance Reassessment Summary" section for recommendations with respect to established tolerance levels.

860.1520 Processed Food and Feed The reregistration requirements for magnitude of the residue in the processed commodities of the following crops have been fulfilled: apples, grapes, and pineapple. The available data indicate that residues do not concentrate significantly in apple juice ( reduction factor of 0.6x), grape juice, and pineapple juice. The available data indicate that residues of triadimefon and its metabolites concentrate 1.6x in apple wet pomace and 4x in raisins; refer to " Tolerance Reassessment Summary" section for recommendations with respect to the need for tolerances as a result of concentration of residues in these processed commodities. The available data also indicate that triadimefon residues of concern concentrate 10x in apple dry pomace, 3x in grape wet pomace, 5x in grape dry pomace, 7x in raisin waste, and 1.3x in pineapple process residue ( pineapple bran); no tolerances are required for these commodities as they are no longer considered significant livestock feed items.

Processing data for sugar beets and wheat have been submitted and reviewed; however, Bayer is no longer supporting use of triadimefon on these crops.

860.1650 Submittal of Analytical Reference Standards An analytical reference standard for triadimefon was submitted by Bayer CropScience in October of 2002 and expires August of 2013. The standard is available at the EPA National Pesticide Standards Repository.

860.1850 Confined Accumulation in Rotational Crops The reregistration requirements for confined rotational crops are fulfilled. Because triadimefon and its regulated metabolites were identified at > 0.01 ppm in various rotational crops at various intervals, limited and/ or field rotational crop studies were required. However, the registrant has since requested removal of all rotatable crop uses from product labels.

860.1900 Field Accumulation in Rotational Crops Studies for field accumulation in rotational crops have not been submitted. The registrant has Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 23 of 44 requested removal of all rotatable crop uses from product labels. Trials for field accumulation in rotational crops are not required at this time. However, if the registrant wishes to allow rotation in the future, field accumulation studies will be needed to set tolerance levels for rotational crops.

Tolerance Reassessment Summary Tolerances for residues in/ on plant and livestock commodities have been established under 40 CFR § 180.410. The tolerances are expressed in terms of residues of triadimefon [ 1( 4 chlorophenoxy) 3,3 dimethyl 1( 1H 1,2,4 triazol 1 yl) 2 butanone] and its metabolites containing chlorophenoxy and triazole moieties ( expressed as the parent compound). The qualitative nature of the residue in plants and livestock is adequately understood. HED has determined that the triadimefon residues of concern in/ on apples, grapes, pears, pineapples, and raspberries for tolerance expression are triadimefon and triadimenol. The reorganization of triadimefon tolerances and tolerance expression for all RACs should be conducted as depicted below in Table 9. A summary of triadimefon tolerance reassessments is presented in Table 10.

Table 9. Reorganization of Triadimefon Tolerances Required Under 40 CFR.

40 CFR Section Reserved For Tolerance Expression § 180.410( a) apple, grape, pear, and pineapple Tolerances are established for the combined residues of the fungicide 1( 4 chlorophenoxy) 3,3 dimethyl 1( 1H 1,2,4 triazol 1 yl) 2 butanone [ triadimefon] and $( 4 chlorophenoxy)"( 1,1 dimethylethyl) 1H 1,2,4 triazole 1 ethanol [ triadimenol], expressed as triadimefon, in or on the following raw agricultural commodities:

§ 180.410( c) raspberry Tolerances with regional registration are established for the combined residues of the fungicide 1( 4 chlorophenoxy) 3,3 dimethyl 1( 1H 1,2,4 triazol 1 yl) 2 butanone [ triadimefon] and $( 4 chlorophenoxy)"( 1,1 dimethylethyl) 1H 1,2,4 triazole 1 ethanol [ triadimenol], expressed as triadimefon, in or on the following raw agricultural commodities:

Tolerances Established Under 40 CFR § 180.410( a)

Sufficient field trial data reflecting the maximum label use pattern are available to reassess the established tolerances for the following RACs as defined: apples, grapes, pears, pineapples, and raspberries. Likewise, acceptable feeding studies are available to reassess the tolerances for the following livestock commodities: milk, eggs, and the fat, meat byproducts, and meat of cattle, goats, horses, and sheep.

The established tolerances for the following plant commodities should be revoked because the registrant is not supporting use of triadimefon on these commodities: barley, milled fractions ( except flour); cucurbits; grass, forage; grass, seed screenings ( including hulls); grass, seed straw ( including chaff); nectarines; sugar beets; sugar beets, tops; wheat, grain; wheat, green forage; wheat, milled fractions ( except flour); and wheat, straw. The established tolerances for residues in dry apple pomace, wet and dry grape pomace, and raisin waste should be revoked because these commodities are no longer considered significant livestock feed items. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 24 of 44 The established tolerances for RACs listed under 40 CFR § 180.410( a) are reassessed at the same levels except those listed for apples, pears, and pineapples; reduced tolerances may be established for these crops to reflect reevaluation of field trial data.

Triadimefon is not registered for use as a direct livestock treatment. The nature of the residue in livestock is adequately defined for the current uses. HED concludes that the supported registered uses on apples, grapes, pears, pineapples, and raspberries result in a 40 CFR § 180.6( a)( 3) situation for ruminant commodities; i. e., there is no reasonable expectation of finite residues in livestock commodities. Therefore, additional data on the transfer of residues to meat, milk, poultry, and eggs are not required and all tolerances for livestock commodities should be revoked.

The available apple processing data indicate that triadimefon residues of concern concentrate in wet pomace ( 1.6x) but do not concentrate in juice ( reduction factor of 0.6x). Based on the HAFT residues for apples (< 0.09 ppm) and the concentration factor for wet pomace, expected triadimefon residues of concern in wet pomace are 0.14 ppm. Because the expected residues are less than the reassessed tolerance for apples ( 0.2 ppm), no tolerance for apple wet pomace is required.

Tolerances To Be Proposed Under 40 CFR § 180.410( a)

The available data indicate that residues of triadimefon concentrate 4x in raisins. Based on HAFT residues for grapes (< 0.62 ppm) and the concentration factor for raisins, expected triadimefon residues of concern in raisins are 2.5 ppm, which is significantly greater than the reassessed tolerance for the RAC ( 1.0 ppm). Therefore, a tolerance of 2.5 ppm must be proposed for residues in raisins.

Tolerances with Regional Registrations Established Under 40 CFR § 180.410( c)

A tolerance with regional registration has been established for raspberries. Sufficient field trial data are available to assess the established tolerance with regional registration for raspberry at the same level under 40 CFR § 180.410( c).

Table 10. Tolerance Reassessment Summary for Triadimefon.

Commodity Current Tolerance ( ppm) Reassessed Tolerance ( ppm) Comment [ Correct Commodity Definition]

Tolerances Established Under 40 CFR § 180.410( a)

Apple 1.0 0.2 New data from field trails show lower residues are expected.

Apple, wet pomace and Apple, dry pomace 4.0 Revoke The available data indicate that a tolerance for wet apple pomace is not required, and dry apple pomace is no longer considered a significant livestock feed item.

Barley, milled fractions ( except flour) 4.0 Revoke Currently, Bayer does not have any registered uses of triadimefon on barley. 1 Beet, sugar 0.5 Revoke Currently, Bayer does not have any registered uses of triadimefon on sugar beets. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 Table 10. Tolerance Reassessment Summary for Triadimefon.

Commodity Current Tolerance ( ppm) Reassessed Tolerance ( ppm) Comment [ Correct Commodity Definition]

25 of 44 Beet, sugar, tops 3.0 Cattle, fat 1.0 Revoke 40 CFR § 180.6( a)( 3) Cattle, meat 1.0 Revoke Cattle, meat byproducts 1.0 Revoke Chickpea, seed 0.1 Revoke Currently, Bayer does not have any registered uses of triadimefon on chickpea plants.

Cucurbits 0.3 Revoke Bayer does not intend to support use of triadimefon on cucurbits.

Eggs 0.04 Revoke Currently, Bayer does not have any registered uses of triadimefon on any poultry feed items. 40 CFR § 180.6( a)( 3)

Goat, fat 1.0 Revoke 40 CFR § 180.6( a)( 3) Goat, meat 1.0 Revoke Goat, meat byproducts 1.0 Revoke Grape 1.0 1.0 No change.

Grape, wet pomace and Grape, dry pomace 3.0 Revoke No longer considered significant livestock feed items. Grape, raisin, waste 7.0 Grass, forage 0.2 Revoke Currently, Bayer does not have any registered uses of triadimefon on pasture or rangeland. Grass, seed screenings 145.0 Grass, straw, grown for seed 105.0 Hog, fat 0.04 Revoke Currently, Bayer does not have any registered uses of triadimefon on any hog feed items. 40 CFR § 180.6( a)( 3) Hog, meat 0.04 Hog, meat byproducts 0.04 Horse, fat 1.0 Revoke 40 CFR § 180.6( a)( 3) Horse, meat 1.0 Horse, meat byproducts 1.0 Milk 0.04 Revoke 40 CFR § 180.6( a)( 3)

Nectarine 4.0 Revoke Currently, Bayer does not have any registered uses of triadimefon on nectarine.

Pear 1.0 0.2 New data from field trails show lower residues are expected.

Pineapple, fresh 3.0 2.0 Reevaluation of data from field trails show lower residues are expected. [ Pineapple] Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 Table 10. Tolerance Reassessment Summary for Triadimefon.

Commodity Current Tolerance ( ppm) Reassessed Tolerance ( ppm) Comment [ Correct Commodity Definition]

26 of 44 Poultry, fat 0.04 Revoke Currently, Bayer does not have any registered uses of triadimefon on any poultry feed items. 40 CFR § 180.6( a)( 3) Poultry, meat 0.04 Poultry, meat byproducts 0.04 Sheep, fat 1.0 Revoke 40 CFR § 180.6( a)( 3) Sheep, meat 1.0 Sheep, meat byproducts 1.0 Wheat, forage 15.0 Revoke Currently, Bayer does not have any registered uses of triadimefon on wheat. Wheat, grain 1.0 Wheat, milled fractions ( except flour) 4.0 Wheat, straw 5.0 Tolerances To Be Proposed Under 40 CFR § 180.410( a)

Grape, raisin None established 2.5 Tolerances Established Under 40 CFR § 180.410( c)

Raspberry 2.0 2.0 No change.

1. Tolerances for barley commodities were revoked in 1997, based on the fact that use on barley had been canceled in 1993. This food additive tolerance was mistakenly re instated when the revocation of all triadimefon food additive tolerances ( due to Delaney clause issues) was withdrawn after FQPA was enacted.

Codex Harmonization The Codex Alimentarius Commission ( Codex) has established several maximum residue limits ( MRLs) for triadimefon in/ on various raw agricultural commodities. The Codex MRLs are expressed in terms of triadimefon per se. Compatibility cannot be achieved with the Codex MRLs because these levels are expressed in terms of triadimefon only; the U. S. tolerances for plant commodities are expressed in terms of triadimefon and triadimenol. Additionally, all U. S. livestock tolerances should be revoked. A numerical comparison of the Codex MRLs and the corresponding reassessed U. S. tolerances is presented in Table 11.

Table 11. Codex MRLs for Triadimefon and Applicable U. S. Tolerances.

Codex Reassessed U. S. Tolerance ( ppm) Codex Comments Commodity MRL1 ( mg/ kg) Step Barley 0.5 CXL None3 Barley straw and fodder, Dry 2 CXL None Chick pea ( dry) 0.05 (*) CXL Revoke Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 Table 11. Codex MRLs for Triadimefon and Applicable U. S. Tolerances.

Codex Reassessed U. S. Tolerance ( ppm) Codex Comments Commodity MRL1 ( mg/ kg) Step 27 of 44 Coffee beans 0.05 (*) CXL None Currants, Black, Red, White 0.2 CXL None Eggs 0.05 (*) CXL Revoke Fodder beet 0.05 (*) CXL None Fodder beet leaves or tops 0.05 (*) CXL None Fruiting vegetables, Cucurbits 0.1 CXL Revoke Grapes 0.5 CXL 1.0 Hops, Dry 10 CXL None Mango 0.05 (*) CXL None Meat ( from mammals other than marine mammals) 0.05 (*) CXL Revoke Milks 0.05 (*) CXL Revoke Oat straw and fodder, Dry 2 CXL None Oats 0.1 CXL None Onion, Welsh 0.05 (*) CXL None Peas ( pods and succulent= immature seeds) 0.05 (*) CXL None Peppers, Sweet 0.1 CXL None Pineapple 22 CXL 2.0 Pome fruits 0.5 CXL None Poultry meat 0.05 (*) CXL Revoke Raspberries, Red, Black 1 CXL 2.0 Rye 0.1 CXL None Rye straw and fodder, Dry 2 CXL None Spring onion 0.05 (*) CXL None Strawberry 0.1 CXL None Sugar beet 0.1 (*) CXL Revoke Sugar beet leaves or tops 2 CXL Revoke Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 Table 11. Codex MRLs for Triadimefon and Applicable U. S. Tolerances.

Codex Reassessed U. S. Tolerance ( ppm) Codex Comments Commodity MRL1 ( mg/ kg) Step 28 of 44 Tomato 0.2 CXL None Wheat 0.1 CXL Revoke Wheat straw and fodder, Dry 2 CXL Revoke 1. Asterisk designates MRL set at the limit of quantitation. 2. Resulting from postharvest application. 3. The basic producer does not have registered uses of triadimefon on this commodity.

Bibliography Agency Memoranda Citations DP Barcode: D174365 Subject: ID HI 920003. Triadimefon: 24 ( c) on pineapple processed commodities in the State of Hawaii. CBTS # 9336 From: J. Morales To: C. Giles Parker and Toxicology Branch Dated: 3/ 9/ 92 MRID: None DP Barcode: D177806 Subject: Triadimefon. Case # 2700. Waiver and Extension Requests: Storage Stability Data and Processing Study. CBRS # 9851. From: L. Cheng To: M. Wilhite Dated: 6/ 9/ 92 MRID: None DP Barcode: D179962 Subject: FIFRA 6( a)( 2) Data and Reregistration of Triadimefon ( Bayleton). Processing Studies for Apples and Grapes. CBRS No. 10114 From: S. Funk To: M. Wilhite Dated: 7/ 24/ 92 MRID: 42346601 and 42346701 DP Barcode: D175489 Subject: PP# 2F2688/ FAP# 2H5636. Triadimefon ( Bayleton ® 50% WP Fungicide; EPA Reg. No. 3125 320) in or on Pineapple Bran as a Feed Additive ( Guideline # 171 4( l)). Evaluation of Analytical Method and Residue Data. CBRS # 9547. From: F. Toghrol To: C. Giles Parker/ J. Stone Dated: 9/ 18/ 92 MRID: 42013201 Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 29 of 44 DP Barcode: D174151 Subject: Triadimefon. List B Reregistration Case No. 2700/ Chemical ID No. 109901. Raw data to upgrade metabolism studies reviewed in Phase 4. Phase 5 Review of subject studies. CBRS No. 9422. From: C. Swartz To: B. Sidwell Dated: 9/ 23/ 92 MRIDs: 42123400 42123404 DP Barcodes: D179335, D181031, and D181032 Subject: Triadimefon. Reregistration Case No. 2700. Guideline 171 4( k) Magnitude of the residue studies for apples, pears, cucumbers, summer squash, cantaloupes, grapes, and pineapples. From: S. Knizner To: M. Wilhite/ B. Sidwell Dated: 12/ 10/ 92 MRIDs: 41809401 and 42342303 42342308 DP Barcodes: D168542 and D178884 Subject: Triadimefon ( 109901): Storage Stability Data, PAM Multiresidue Methods, Product Chemistry Data. CBRS Nos. 8566 and 9929. From: S. Hummel To: M. Wilhite/ B. Sidwell Dated: 12/ 22/ 92 MRIDs: 41976601, 41976602, and 42307801 42307803 DP Barcode: D183726 Subject: PP# 3E4164 Triadimefon ( Bayleton ® 50% Wettable Powder ( EPA Reg. No. 3125 320) and Bayleton ® 50% Wettable Powder Fungicide in water soluble pouches ( EPA Reg. No. 3125 340)) in or on the Pome Fruit Crop Group. CBTS No. 10762 From: D. Davis To: H. Jamerson Dated: 2/ 12/ 93 MRID: None DP Barcode: D180656 Subject: PP3E2938. Triadimefon on coffee. Amendment of 5/ 28/ 92. CB No. 10239. From: R. Cook To: C. Giles Parker Dated: 7/ 6/ 93 MRIDs: 42332701 DP Barcode: D194719 Subject: Triadimefon. List B Reregistration Case No. 2700/ Chemical ID No. 109901. Submission of Raw Data to Upgrade Cucumber and Tomato Metabolism Studies. CBRS No. 12515 From: C. Swartz To: B. Sidwell Dated: 10/ 20/ 93 MRIDs: 42798900 and 42798901 DP Barcode: D194786 Subject: Triadimefon. Poultry Metabolism Study. Reregistration Case No. 2700. Chemical No. 109901. CBRS # 12530. From: Steven A. Knizner To: M. Wilhite Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 30 of 44 Dated: 11/ 2/ 93 MRID: 42864901 DP Barcode: D194819 Subject: Triadimefon. Ruminant Metabolism Study. Reregistration Case No. 2700. Chemical No. 109901. CBRS # 12514. From: Steven A. Knizner To: M. Wilhite Dated: 11/ 2/ 93 MRID: 42856801 DP Barcode: D186937 Subject: Triadimefon. Confined Rotational Crop Study. Reregistration Case No. 2700. Chemical No. 109901. CBRS # 11212. From: Steven A. Knizner To: M. Wilhite Dated: 11/ 3/ 93 MRID: 42613301 DP Barcode: D194676 Subject: Triadimefon. Wheat Metabolism Study. Reregistration Case No. 2700. Chemical No. 109901. CBRS # 12527. From: Steven A. Knizner To: M. Wilhite Dated: 11/ 3/ 93 MRID: 42853401 DP Barcode: D194783 Subject: Triadimefon. Storage Stability Study. Reregistration Case No. 2700. Chemical No. 109901. CBRS # 12528. From: Steven A. Knizner To: M. Wilhite Dated: 11/ 7/ 93 MRID: 42857401 DP Barcode: None Subject: Triadimefon. Issues to be Presented at the 12/ 1/ 93 Meeting of the HED Metabolism Committee. Reregistration Case No. 2700. Chemical No. 109901. From: Steven A. Knizner To: HED Metabolism Committee Dated: 11/ 29/ 93 MRIDs: None DP Barcode: None Subject: Triadimefon. Addendum to Wheat, Ruminant, and Poultry Metabolism Studies and Confined Rotational Crop Study. Reregistration Case No. 2700. Chemical No. 109901. From: Steven A. Knizner To: M. Wilhite Dated: 12/ 9/ 93 MRIDs: 42853401, 42856801, 42864901, and 42613301 DP Barcode: None Subject: Triadimefon. Outcome of the 12/ 1/ 93 Meeting of the HED Metabolism Committee. Reregistration Case No. 2700. Chemical No. 109901. From: Steven A. Knizner To: Files and HED Metabolism Committee Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 31 of 44 Dated: 1/ 3/ 94 MRIDs: None DP Barcode: D208890 Subject: Triadimefon. Data Submitted to Upgrade Ruminant and Poultry Metabolism Studies and Analysis of Tissues from Metabolism Study with Analytical Enforcement Method. Reregistration Case No. 2700. Chemical No. 109901. CBRS # 14659 From: Steven A. Knizner To: M. Wilhite Dated: 12/ 16/ 94 MRIDs: 43418301, 43418302, and 43418303 DP Barcodes: D209623 and D209629 Subject: ID # s 003125 00320 Bayleton 50% WP Fungicide & # 003125 00340 Bayleton 50% WP Fungicide: Triadimefon in/ on Pineapple; Amendment dated November 14, 1994 From: Amended Registration Team To: C. Giles Parker/ J. Stone Dated: 2/ 21/ 95 MRID: None DP Barcode: D210160 Subject: Triadimefon. Meat, Milk, Eggs Storage Stability Study. Reregistration Case No. 2700. Chemical No. 109901. CBRS # 14826 From: S. Knizner To: M. Wilhite Dated: 2/ 23/ 95 MRID: 43462401 DP Barcode: D205423 Subject: Triadimefon. Grape Processing Study. Reregistration Case No. 2700. Chemical No. 109901. CBRS # 14186 From: S. Knizner To: R. Kendall Dated: 2/ 23/ 95 MRID: 43284401 DP Barcode: D215215 Subject: Triadimefon on Apples and Grapes. Application of DES Proviso to Existing Feed Additive Tolerances. CBTS # 15526 From: G. Herndon To: E. Haeberer Dated: 5/ 24/ 95 MRID: None DP Barcode: None Subject: PP# 3E4164. Triadimefon in or on the Pome Fruit Crop Group. Addendum to 2/ 12/ 93 Memorandum. From: D. Davis To: H. Jamerson, J. Stone, and R. Kendall Dated: 9/ 13/ 95 MRID: None DP Barcode: D220220 Subject: Triadimefon  Evaluation of the Need for the Existing Food Additive Tolerance on Wheat Milled Fractions ( Except Flour). CBTS # 16337. From: G. Kramer Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 32 of 44 To: N. Nazmi Dated: 10/ 25/ 95 MRID: None DP Barcode: D225223 Subject: Triadimefon  Response to Comments by Bayer on the Proposed Revocation of the Existing Food Additive tolerance on Wheat Milled Fractions ( Except Flour). From: G. Kramer To: N. Nazmi Dated: 4/ 25/ 96 MRID: None DP Barcode: D223368 Subject: Triadimefon. PP# 2E4044. IR 4 Petition for Tolerance In/ On Artichoke, globe. From: S. Knizner To: H. Jamerson Dated: 9/ 3/ 96 MRID: 43897501 DP Barcode: D229635 Subject: ID# 96MN0004 Section Crisis 18 Exemption for Use of Triadimefon on Chili peppers in the State of New Mexico. From: S. Knizner, C. Lewis, W. Dykstra, and D. Davis To: D. Deegan Dated: 9/ 17/ 96 MRID: None DP Barcodes: D234272 and D235085 Subject: ID# 97MI0006 & 97CA0032. Section 18 Exemptions for Use of Triadimefon on Asparagus in Michigan and Artichokes in California. From: S. Knizner, S. Williams Foy, W. Dykstra, C. Lewis, and M. Nelson To: O. Odiott and D. Deegan/ M. Johnson Dated: 7/ 30/ 97 MRID: None DP Barcode: D238236 Subject: ID# 97MI0006 & 97CA0032. Section 18 Exemptions for Use of Triadimefon on Asparagus in Michigan and Artichokes in California. From: R. Loranger To: O. Odiott and D. Deegan/ M. Johnson Dated: 8/ 14/ 97 MRID: None DP Barcodes: D220498 and D238509 Subject: PP# 3E4164. Triadimefon on Pome Fruits. Residue Chemistry Disciplinary Review of the IR 4 Amendments dated 10/ 6/ 95 and 3/ 12/ 97: Revised Sections B and F. From: M. Nelson To: H. Jamerson Dated: 3/ 6/ 98 MRID: None Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 33 of 44 DP Barcode: D238130 Subject: PP# 2E4044. Triadimefon on Artichokes. Residue Chemistry Disciplinary Review of the IR 4 Amendment dated 6/ 7/ 96. Revised Sections B and F. From: M. Nelson To: H. Jamerson Dated: 3/ 6/ 98 MRID: None DP Barcode: None Subject: Triadimefon. Outcome of the 12/ 1/ 93 Meeting of the HED Metabolism Committee. From: S. Knizner To: Files and HED Metabolism Committee. Dated: 1/ 3/ 94 MRID: None DP Barcodes: D222403, D227497, and D227543 Subject: Independent Laboratory Validation, Radiovalidation Data, and Storage Stability Data From: J. Punzi To: B. Chambliss Dated: 7/ 13/ 00 MRIDs: 43870101, 44038901, 44041001, and 44041002 DP Barcode: D321636 Subject: Triadimefon. Registrants Response to Residue Chemistry Data Requirements. Magnitude of Triadimefon Residues of Concern in Apple Processed Commodities. From: S. Ary To: R. Griffin and J. Pates Dated: 8/ 31/ 2005 MRID: 43948601 Master Record Identification Numbers 41809401 Williams, B. ( 1991) Triadimefon: Magnitude of the Residue Crop Field Trials: Lab Project Number: 38613 1: BL19GR01: 100122. Unpublished study prepared by Analytical Bio Chemistry Laboratories Inc. 323 p.

41976601 Ver Hey, M. ( 1991) Bayleton, KWG 1323 and KWG 1342: Multiresidue Method Testing: Lab Project Number: MOBAY/ 1093: BL161601. Unpublished study prepared by Colorado Analytical Research & Dev., Corp. 380 p.

41976602 Williams, B.; Conrath, B. ( 1991) Triadimefon/ Triadimenol Freezer Storage Stability Study in Wheat Gain, Grapes, and Tomatoes: Amended Report: Lab Project Number: 36987 1: BL142301: 100105. Unpublished study prepared by Analytical Bio Chemistry Laboratories. 417 p.

42013201 Pither, K. ( 1991) Triadimefon ( 500DF): Magnitude of the Residue on Pineapple Processed Products: Lab Project Number: BL19PN02B: 101325. Unpublished study prepared by ABC Labs, Inc. and Maui Pineapple Company, Ltd. 324 p.

42123401 Krolski, M. ( 1991) Addendum I: Raw Data on the Fate of ? carbon 14| Triadimefon on Tomatoes and Cucumbers: Lab Project Number: 68593  1. Unpublished study prepared by Stoner Labs, Inc. 20 p.

42123402 Minor, R. ( 1991) Addendum I: Raw Data for the Metabolism of Triadim efon in Apples: Lab Project Number: 53621 1. Unpublished study prepared by Mobay Corp. 19 p.

42123403 Duah, F. ( 1991) Addendum I: Raw Data on The Metabolism of Bayleton on Grapes: Lab Project Number: 88790 1. Unpublished study pre pared by Mobay Corp. 27 p. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 34 of 44 42123404 Chopade, H. ( 1991) Addendum I: Raw Data for the Metabolism of Triadimefon in Male and Female Pigs: Lab Project Number: 66509 1. 51 p.

42332701 Chickering, C.; Williams, B. ( 1992) Triadimefon: Magnitude of the Residue on Coffee Beans: Lab Project Number: 39264 1: BL19CF01. Unpublished study prepared by ABC Laboratories, Inc. and Mobay Corp. 186 p.

42342303 Burger, R. ( 1992) Triadimefon ( 50DF) Magnitude of the Residue on Apples: Lab Project Number: BL 19AP01: 39590: 102625. Unpublished study prepared by Miles, Inc. and ABC Laboratories. 386 p.

42342304 Burger, R. ( 1992) Triadimefon ( 50DF) Magnitude of the Residue on Cantaloupe: Lab Project Number: BL 19CP01: 39585: 102628. Unpublished study prepared by Miles, Inc. and ABC Laboratories. 319 p.

42342305 Burger, R. ( 1992) Triadimefon ( 50DF) Magnitude of the Residue on Cucumber: Lab Project Number: BL 19CU01: 39586: 102630. Unpublished study prepared by Miles, Inc. and ABC Laboratories. 409 p.

42342306 Burger, R. ( 1992) Triadimefon ( 50DF) Magnitude of the Residue on Pears: Lab Project Number: BL 19PR01: 39592: 102626. Unpublished study prepared by Miles, Inc. and ABC Laboratories. 303 p.

42342307 Burger, R. ( 1992) Triadimefon ( 50DF) Magnitude of the Residue on Pineapple: Lab Project Number: BL 19PN02: 39256: 102649. Unpublished study prepared by Miles, Inc., ABC Laboratories, and Dole Packaged Foods Co. 416 p.

42342308 Burger, R. ( 1992) Triadimefon ( 50DF) Magnitude of the Residue on Summer Squash: Lab Project Number: BL 19SQ01: 39589: 102629. Unpublished study prepared by Miles, Inc. and ABC Laboratories. 420 p.

42346601 Burger, R. ( 1992) Triadimefon ( 50DF) Magnitude of the Residue on Processed Apple Commodities: Lab Project Number: BL 19AP02: 39591: 102636. Unpublished study prepared by Miles Inc. and ABC Laboratories. 233 p.

42346701 Burger, R. ( 1992) Triadimefon ( 50DF) Magnitude of the Residue on Processed Grape Commodities: Lab Project Number: BL19GR02: 39587: RP 5522. Unpublished study prepared by Miles Inc., ABC Laboratories, Inc. and The National Food Laboratory Inc. 277p.

42613301 Mattern, G. C., Parker, G. D., and Wendt, S. N. ( 1992) Confined Accumulation of [ phenyl UL 14C] Triadimefon Residues in Rotational Crops. Laboratory Study Nos.: Miles, Inc.: BL051601; Plant Sciences, Inc.: 91.027; PTRL West, Inc.: P309W; Miles Report No. 103806. Unpublished study conducted by Plant Sciences, Inc., Watsonville, CA and PTRL West, Inc., Richmond, CA, and sponsored by Miles, Inc., Kansas City, MO. 152 p.

42798901 Krolski, M. ( 1993) Fate of Bayleton( carbon 14) as a 25 Percent Wettable Powder on Tomatoes and Cucumbers. Mass Spectral Data on ( carbon 14) Triadimefon Residues.

42853401 Chopade, H. ( 1993) Metabolism of ( Phenyl UL( carbon 14)) Triadimefon in Wheat: Lab Project Number: BL041601: 105162. Unpublished study prepared by Miles Inc., Agricultural Div. 141 p.

42856801 Hall, L.; Hartz, A. ( 1993) The Metabolism of ( carbon 14) Triadimefon in the Lactating Goat: Lab Project Number: BL041001: 105161. Unpublished study prepared by Miles Inc. 160 p.

42857401 Williams, B. and Chickering, C. ( 1993) Triadimefon and Metabolites Freezer Storage Stability Study in Raw Agricultural Commodities and Processed Products Agricultural Commodities and Processed Products: Lab Project Number: 396832: BL131601: 102641 1. Unpublished study prepared by ABC Labs, Inc. 150 p.

42864901 Duah, F.; Smasal, T. ( 1993) Metabolism of Triadimefon in Laying Hens: Lab Project Number: BL040501: 105183. Unpublished study prepared by Miles Inc. 129 p. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 35 of 44 43284401 Burger, R. ( 1994) Triadimefon ( 50DF): Magnitude of the Residue in Processed Grape Commodities: Lab Project Number: 105043: BL19GR03: 40712. Unpublished study prepared by Miles Inc. in cooperation with ABC Laboratories, Inc. and The National Food Laboratory, Inc. 648 p.

43418301 Hall, L.; Hartz, A. ( 1994) The Metabolism of ( carbon 14) Triadimefon in the Lactating Goat: Addendum 1: Additional Data as Requested by the EPA: Lab Project Number: BL041001: 105161 1. Unpublished study prepared by Miles, Inc. 12 p.

43418302 Duah, F.; Myers, T. ( 1994) Metabolism of Triadimefon in Laying Hens: Addendum 1: Additional Data as Requested by EPA: Lab Project Number: BL040501: 105183 1. Unpublished study prepared by Miles, Inc. 17 p.

43418303 Duah, F.; Myers, T.; Freeseman, P. ( 1994) Extraction Efficiency of the Analytical Method for Triadimefon Residues in Meat, Milk, and Eggs: Lab Project Numbers: BL200201: 106449. Unpublished study prepared by Miles, Inc. 44 p.

43462401 Duah, F. ( 1994) Storage Stability of Triadimefon Residues in Animal Tissues, Milk, and Eggs: Lab Project Number: BL130201: 106638. Unpublished study prepared by Miles Inc. 37 p.

43870101 Bajzik, M. ( 1995) Independent Laboratory Validation of the Analytical Residue Method for Triadimefon and Metabolites in Plant Matrices ( Report No. 106549): Lab Project Number: A012.014: BL111601: 107141. Unpublished study prepared by Huntingdon Analytical Services. 121 p.

43897501 Thompson, D. ( 1996) Triadimefon in/ on Artichokes: ( Additional Magnitude of the Residue Trials): Lab Project Number: 3530: 3530. AA CAR02: 3530. AA CA03. Unpublished study prepared by IR 4 Western Region Residue Lab. 335 p.

44029301 Grace, T. ( 1996) BAYLETON 50WP  Magnitude of the Residue in Wheat Processed Products: Lab Project Number: BL19WH02: 107130: PR95322. Unpublished study prepared by Bayer Corp.; Texas A& M University; and Maxim Technologies, Inc. 2508 p.

44038901 Lenz, C. ( 1996) Triadimefon and Metabolites Freezer Storage Stability Study in Raw Agricultural Commodities and Processed Commodities: Addendum 2: Lab Project Number: BL131601: 102641 2: 39683. Unpublished study prepared by ABC Laboratories, Inc. 586 p.

44041001 Chopade, H. ( 1996) Metabolism of ( Phenyl UL( carbon 14)) Triadimefon in Wheat: Addendum 1 Storage Stability of ( carbon14) KWG 1732 in Wheat Grain: Lab Project Number: BL221601: 105162 1. Unpublished study prepared by Bayer Corp. 30 p.

44041002 Chopade, H. ( 1996) Extraction Efficiency of the Analytical Residue Method for the Determination of Triadimefon and Metabolite Residues in Plant Matrices: Determination of Aged ( carbon 14) Triadimefon Residues in Wheat Grain: Lab Project Number: BL221601: 107343. Unpublished study prepared by Bayer Corp. 35 p.

92188025 Chopade, H. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00025540. The Metabolism of BAYLETON in Apples: Project Report No. 53621. Prepared by MOBAY CORPORATION. 14 p.

92188026 Mango, R.; Puhl, R.; Thornton, J. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00025540. The Metabolism of BAYLETON in Apples: Project No. 53621. Prepared by MOBAY CORPORATION. 26 p.

92188027 Chopade, H. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00031440 and Related MRIDs 00031441. Fate of BAYLETON Carbon 14 as a 25% Wettable Powder on Tomatoes and Cucumbers: Project Report Nos. 68593 and 68594. Prepared by MOBAY CORPORATION. 13 p.

92188028 Nye, D. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00031440. Fate of BAYLETON Carbon 14 as a 25 Percent Wettable Powder on Tomatoes and Cucumbers: Project Report 68593. Prepared by STONER LABORATORIES, INC. 33 p. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 36 of 44 92188029 Puhl, R. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00031441. Further Identification of Polar Activity from BAYLETON Cucumber and Tomato Metabolism Samples: Project Report No. 68594. Prepared by MOBAY CORPORATION. 10 p.

92188030 Chopade, H. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00098115. Metabolism of BAYLETON in Wheat: Project Report No. 80293. Prepared by MOBAY CORPORATION. 14 p.

92188031 Morgan, J.; Lenz, M. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00098115. Metabolism of BAYLETON in Wheat: Project Report No. 80293. Prepared by MOBAY CORPORATION. 29 p.

92188032 Chopade, H. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00150893. Metabolism of BAYLETON on Grapes: Project Report No. 88790. Prepared by MOBAY CORPORATION. 12 p.

92188033 Fredrickson, R. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00150893. Metabolism of BAYLETON on Grapes: Project Report No. 88790. Prepared by MOBAY CORPORATION. 21 p.

92188034 Chopade, H. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00025543. Metabolism of BAYLETON in the Cow: Project Report No. 66202. Prepared by MOBAY CORPORATION. 11 p.

92188035 Fredrickson, D. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00025543. Metabolism of BAYLETON in the Cow: Project Report No. 66202. Prepared by MOBAY CORPORATION. 19 p.

92188036 Premkumar, N. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00033058. Metabolism of BAYLETON in Male and Female Pigs: Project No. 66509. Prepared by MOBAY CORPORATION. 16 p.

92188037 Pither, K. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00033058. Metabolism of BAYLETON in Male and Female Pigs: Project Report No. 66509. Prepared by MOBAY CORPORATION. 25 p.

92188038 Mathew, A. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00033070. The Fate of BAYLETON Carbon 14 in Poultry: Project Report No. 67482. Prepared by MOBAY CORPORATION. 16 p.

92188039 Nye, D. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00033070. The Fate of BAYLETONCarbon 14 in Poultry: Project Report No. 67482. Prepared by STONER LABORATORIES, INC. 67 p.

92188040 Obrist, J.; Nichols, S.; Leimkuehler, W. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00025546. An Interference Study for the BAYLETON and KWG 0519 Residue Method for Crops: Project Report No. 68006. Prepared by MOBAY CORPORATION. 208 p.

92188041 Leimkuehler, W. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00125782. An Interference Study for BAYLETON Residue Method for Crops  Resolution of Interference for KWG 1342 and KWG 1323: Project Report No. 80567. Prepared by MOBAY CORPORATION. 225 p.

92188042 Chopade, H. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00149163 and Related MRIDs 00025546, 00125782. Residue Analysis Procedure for BAYLETON and Metabolites in Plants: Project Report Nos. 80488, 68006 and 80567. Prepared by MOBAY CORPORATION. 16 p.

92188043 Obrist, J.; Leimkuehler, W. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00149163. Residue Analysis Procedure for BAYLETON and Metabolites in Barley and Wheat: Project Report No. 80488. Prepared by MOBAY CORPORATION. 28 p.

92188044 Minor, R. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00090019 and Related MRIDs 00090020, 00063837, 00072538, 00149342, 00063835. Analytical Methods for BAYLETON in Various Animal Tissues: Project Report Nos. 69531, 80265, 68705, 68798, 69028 and 68887. Prepared by ANALYTICAL DEVELOPMENT CORP. 21 p.

92188045 Kruplak, J. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00090019. BAYLETON Total Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 37 of 44 Residue Method Verification ( Bovine): Project Report No. 69531. Prepared by ANALYTICAL DEVELOPMENT CORP. 158 p.

92188046 Obrist, J. Nichols, S. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00063835. An Interference Study for the BAYLETON and KWG 0519 Residue Method for Bovine Tissues and Milk: Project report No. 68887. Prepared by MOBAY CORPORATION. 67 p.

92188047 Kruplak, J. Weissenburger, B. Bache, . ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00063837. Determination of BAYLETON and KWG 0519 in Cattle Tissues: Project Report No. 68705. Prepared by ANALYTICAL DEVELOPMENT CORP. 31 p.

92188048 Kruplak, J. Bache, B. Breault, G. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00072538. Residue Analysis Procedure for the Determination of BAYLETON and KWG 0519 in Bovine Milk: Project Report No. 68798. Prepared by ANALYTICAL DEVELOPMENT CORP. 19 p.

92188051 Premkumar, N. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00025541 and Related MRIDs 00098117, 41027902. Storage Stability of BAYLETON, BAYTAN, KWG 1323 and KWG 1342 in Apple Peel, Potatoes, Grapes and Wheat Green Forage; and Storage Stability of KWG 1323 and KWG 1342 in Wheat Grain: Project Report Nos. 54192, 80338 and 98432. Prepared by MOBAY CORPORATION. 11 p.

92188052 Thornton, J. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00025541. The Stability of BAYLETON and KWG 0519 Residues in Apple Peel During Frozen Storage: Project Report No. 54192. Prepared by MOBAY CORPORATION. 8 p.

92188053 Fredrickson, D. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00098117. The Stability of BAYLETON and BAYTAN Residues in Wheat Forage During Storage: Project Report No. 80338. Prepared by MOBAY CORPORATION. 7 p.

92188054 Bornatsch, W. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00090021. Effect of Feeding BAYLETON and the Metabolite KWG 0519 ( BAYTAN) to Dairy Cattle  Total Residue: Project Report No. 69930. Prepared by MOBAY CORPORATION. 9 p.

92188055 Kruplak, J. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00090021. Effect of Feeding BAYLETON and the Metabolite KWG 0519 ( BAYTAN) to Dairy Cattle  Total Residues: Project Report No. 69930. Prepared by ANALYTICAL DEVELOPMENT CORP. 247 p.

92188056 Mathew, A. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00090022. Effect of Feeding BAYLETON and the Metabolite KWG 0519 ( BAYTAN) to Poultry  Total Residue: Project No. 80281. Prepared by MOBAY CORPORATION. 12 p.

92188057 Kruplak, J.; and Weissenburger, B. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00090022. Effect of Feeding BAYLETON and the Metabolite KWG 0519 ( BAYTAN) to Poultry  Total Residues: Project Report No. 80281. Prepared by ANALYTICAL DEVELOPMENT CORP. 174 p.

92188059 Leslie, W. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00098114 and Related MRIDs 00149329. Triadimefon ( BAYLETON 50WP Formulation)  Magnitude of the Residues on Barley: Objective No. ( 3015) Project Report Nos 80492, 80493, 80541, 80543, 80554, 80555, 80556, 80559, 80561, 82820, 82826 and 82827; Mobay Report 100112 1. Prepared by MOBAY CORPORATION. 12 p.

92188060 Leslie, W. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00067381 and Related MRIDs 00109463. Triadimefon ( BAYLETON 25WP Formulation)  Magnitude of the Residues on Chick Peas: Project Report Nos. 68905, 68906, 68907, 68908, 68909, 80723, 80930 and 80931; Mobay Report No. 100117 1. Prepared by MOBAY CORPORATION. 13 p.

92188061 Biehn, W. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00143953 and Related MRIDs 00153279. Triadimefon: Magnitude of the Residue on Raspberries: IR 4 No. 2552. Prepared by ICI Americas Inc. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 38 of 44 20 p.

92188062 Leslie, W. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00072532 and Related MRIDs 00149342. Triadimefon ( BAYLETON 50WP Formulation)  Magnitude of the Residues on Seed Grass: Project Report Nos. 80670, 80673, 80674, 80675 and 80676; Mobay Report No. 100114 1. Prepared by MOBAY CORPORATION. 12 p.

92188064 Leslie, W. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00098114 and Related MRIDs 00149329, 00061736. Magnitude of the Residues on Wheat: Objective No. ( 3012): Report Nos. 80494, 80495, 80530, 80542, 80545, 80546, 80547, 80550, 80551, 80552, 80553, 82821, 82874, 84208, 82822 and 82824; Mobay Report No. 100111 1. Prepared by MOBAY CORPORATION. 14 p.

92188074 Leslie, W. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00098114 and Related MRIDs 00149329, 00061736. Triadimefon ( BAYLETON 50WP Formulation)  Magnitude of the Residues on Wheat: ( Report Nos. 80494, 80495, 80530, 80542, 80545, 80546, 80547, 80550, 80551, 80552, 80553, 82821, 82874, 84208, 82822, 82824); Mobay Report No. 100111. Prepared by MOBAY CORPORATION. 219 p.

92188075 Leslie, W. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00072532 and Related MRIDs 00149342. Triadimefon ( BAYLETON 50WP Formulation)  Magnitude of the Residues on Seed Grass: Project Report Nos. ( 80670, 80673, 80674, 80675, 80676, 82848, 82854, 82855, 82856, 82857, 82858); Mobay Report 100114. Prepared by MOBAY CORPORATION. 121 p.

92188076 Leslie, W. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00098114 and Related MRIDs 00149329. Magnitude of the Residues on Barley: Project Nos. ( 80492, 80493, 80541, 80543, 80551, 80554, 80555, 80558, 80559, 80560, 80561, 82826, 84207); Mobay Report No. 100112. Prepared by MOBAY CORPORATION. 182 p.

92188063 Leslie, W. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00128337. Triadimefon ( BAYLETON 50WP Formulation) Magnitude of the Residues on Sugar Beets: Project Report Nos. 81198, 81199, 82800, 82801, 82802, 82803, 82804, 82805, 82806, 82807, 82808, 82809, 82811, 82814, 82815, 82816, 82817 and 82818; Mobay Report 100115 1. Prepared by MOBAY CORPORATION. 17 p.

92188065 Leslie, W. ( 1990) Mobay Corporation Phase 3 Summary of MRID 00128337. Triadimefon ( BAYLETON 50WP Formulation)  Magnitude of the Residue in Unprocessed Sugar Beets and Sugar Beet Processed Products: Project Report Nos. 84211, 84212 and 82811; Mobay Report No. 100116 1. Prepared by MOBAY CORPORATION. 12 p.

92188069 Leslie, W. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00128337. Triadimefon ( BAYLETON 50WP Formulation)  Magnitude of the residues in Unprocessed Sugar Beets and Sugar Beet processed Products: Project Nos. ( 82811, 84211, 84212); Mobay Report No. 100116. Prepared by MOBAY CORPORATION. 56 p.

92188073 Leslie, W. ( 1990) Mobay Corporation Phase 3 Reformat of MRID 00128337. Triadimefon ( BAYLETON 50WP)  Magnitude of the Residues on Sugar Beets: ( Project Nos. 81198, 81199, 82205, 82206, 82207, 82800, 82801, 82802, 82812, 82813, 82814, 82815, 82816, 82817, 82818); Mobay Report No. 10115. Prepared by MOBAY CORPORATION. 204 p. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 39 of 44 Appendix 1. Food/ Food Use Patterns for Triadimefon.

This document was originally prepared by the Biological and Economic Analysis Division ( BEAD). Current as of: 5/ 9/ 2005.

SITE NAME LIMITATIONS Application Timing ( for any Reg.# at any rate)

Application Type ( for any Reg.# at any rate). Max. Single Appl. Form Code( s) Max. Seasonal Max. #

Apps/ M R I R E I PHI/ PGI/ PSI Use Limitations ( May not Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 40 of 44 Application Equipment ( for any Reg.# at any rate). Rate to a Single Site Rate cc & yr apply to all Reg. # s)

APPLE 12 months rotational/ plant back crop restriction.

45 day( s) preharvest interval.

Do not apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark.

Do not apply through any type of irrigation system.

Do not apply when drift is likely to occur.

Do not contaminate water by cleaning of equipment or disposal of equipment wash waters.

Do not contaminate water, food, or feed by storage or disposal.

Do not graze livestock in treated orchards.

Do not use clippings for animal feed.

Do not use on crops grown for food or forage.

Groundwater restriction.

__ months rotational/ plant back crop restriction.

Delayed dormant through petal fall High volume spray ( dilute) / Low volume spray ( concentrate).

Aircraft / High volume ground sprayer / Low volume ground sprayer. 0.25 lb A WP 0.75 lb/ cc NS NS 7 12 h Delayed dormant High volume spray ( dilute) / Low volume spray ( concentrate).

Aircraft / High volume ground sprayer / Low volume ground sprayer. 0.25 lb A WP 0.75 lb/ cc NS NS AN 12 h Foliar High volume spray ( dilute) / Low volume spray ( concentrate).

Aircraft / High volume ground sprayer / Low volume ground sprayer. 0.25 lb A WP 0.75 lb/ cc NS NS AN 12 h When needed High volume spray ( dilute).

High volume ground sprayer. 0.2469 lb A WP 9.26E 0 3 lb/ cc 3/ cc NS 7 NS GRAPES 12 months rotational/ plant back crop restriction.

14 day( s) preharvest interval.

Do not apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark.

Do not apply through any type of irrigation system. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 41 of 44 Do not apply when drift is likely to occur.

Do not contaminate water by cleaning of equipment or disposal of equipment wash waters.

Do not contaminate water, food, or feed by storage or disposal.

Do not use clippings for animal feed.

Do not use on crops grown for food or forage.

Groundwater restriction.

__ months rotational/ plant back crop restriction.

Bloom Low volume spray ( concentrate).

Aircraft / Low volume ground sprayer. 0.1875 lb A WP 0.5625 lb/ cc NS NS 14 12 h Delayed dormant through petal fall Low volume spray ( concentrate).

Aircraft. 0.125 lb A WP 0.5625 lb/ cc NS NS 7 12 h Foliar Low volume spray ( concentrate) / Spray.

Aircraft / Ground / Low volume ground sprayer. 0.1875 lb A FlC, WP 0.5625 lb/ cc NS NS 14 12 h Posttransplant Low volume spray ( concentrate).

Low volume ground sprayer. 0.125 lb A WP 0.5625 lb/ cc NS NS 7 12 h Prebloom through petal fall High volume spray ( dilute) / Low volume spray ( concentrate).

Aircraft / High volume ground sprayer / Low volume ground sprayer. 0.1875 lb A WP 0.5625 lb/ cc 3/ cc NS 14 12 h Prebloom Low volume spray ( concentrate).

Aircraft / Low volume ground sprayer. 0.1875 lb A WP 0.5625 lb/ cc NS NS 14 12 h When needed High volume spray ( dilute).

High volume ground sprayer. 0.1874 lb A WP 0.01405 lb/ cc 3/ cc NS 7 NS PEAR 12 months rotational/ plant back crop restriction.

45 day( s) preharvest interval.

Do not apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 42 of 44 Do not apply through any type of irrigation system.

Do not apply when drift is likely to occur.

Do not contaminate water by cleaning of equipment or disposal of equipment wash waters.

Do not contaminate water, food, or feed by storage or disposal.

Do not graze livestock in treated orchards.

Do not use clippings for animal feed.

Do not use on crops grown for food or forage.

Groundwater restriction.

__ months rotational/ plant back crop restriction.

Delayed dormant through petal fall High volume spray ( dilute) / Low volume spray ( concentrate).

Aircraft / High volume ground sprayer / Low volume ground sprayer. 0.25 lb A WP 0.75 lb/ cc 3/ cc NS 7 12 h Delayed dormant High volume spray ( dilute) / Low volume spray ( concentrate).

Aircraft / High volume ground sprayer / Low volume ground sprayer. 0.25 lb A WP 0.75 lb/ cc NS NS AN 12 h Foliar High volume spray ( dilute) / Low volume spray ( concentrate).

Aircraft / High volume ground sprayer / Low volume ground sprayer. 0.25 lb A WP 0.75 lb/ cc NS NS AN 12 h When needed High volume spray ( dilute).

High volume ground sprayer. 0.003086 lb/ 5 gal WP 9.26E 0 3 lb/ cc 3/ cc NS 7 NS PINEAPPLE 12 months rotational/ plant back crop restriction.

Do not apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark.

Do not apply through any type of irrigation system.

Do not apply when drift is likely to occur.

Do not contaminate water by cleaning of equipment or disposal of equipment wash waters.

Do not contaminate water, food, or feed by storage or disposal.

Do not feed waste from treated pineapples to dairy or meat animals.

Do not use forage or fodder for animal feed.

Do not use on crops grown for food or forage.

Groundwater restriction.

Geographic allowable: HI Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 43 of 44 Postharvest Dip treatment / Seed treatment / Spray.

Dip tank / Sprayer. 0.28125 lb/ 100 gal DF, WP NS NS NS NS 12 h Seed piece Dip treatment.

Dip tank. 0.28125 lb/ 100 gal DF, WP NS NS NS NS 12 h When needed Directed spray.

Hand held sprayer. 0.28125 lb A WP NS 1/ cc NS NS 12 h RASPBERRY ( BLACK, RED) 1 day( s) preharvest interval.

12 months rotational/ plant back crop restriction.

Do not apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark.

Do not apply through any type of irrigation system.

Do not apply when drift is likely to occur.

Do not contaminate water by cleaning of equipment or disposal of equipment wash waters.

Do not contaminate water, food, or feed by storage or disposal.

Do not use clippings for animal feed.

Groundwater restriction.

__ months rotational/ plant back crop restriction.

Geographic allowable: CA Foliar Low volume spray ( concentrate).

Low volume ground sprayer. 0.125 lb A WP NS NS 7/ 1 yr 28 12 h PRODUCT NUMBERS CONTAINED IN THIS REPORT 000264 00737, 000264 00757, 000432 01293, 000432 01294, HI03000400, HI92000300 HOMEOWNER PRODUCTS CONTAINED IN THIS REPORT 000432 01293 HEADER ABBREVIATIONS Site Name  The site name refers to the entity ( crop, building, surface or article) where a pesticide is applied and/ or which is being protected.

Limitations  Precautionary statements related to the use of the product( s).

Application Timing  The timing of pesticide application and is the primary application sort ( not aggregated).

Application Type  The type of pesticide application ( aggregated).

Application Equipment  The equipment used to apply pesticide ( aggregated). Triadimefon Summary Analytical Chemistry and Residue Data DP Barcode: 314742 44 of 44 Max. Single Appl. Rate to a Single Site  Maximum Dose for a single application to a single site. System calculated.

Form  The physical form of the end use product found in the container.

Max Seasonal Rate  The maximum amount of pesticide that can be applied to a site in one growing season (/ cc) and during the span of one year (/ yr).

Max. # Apps/ cc & yr  Maximum Number of Applications per crop cycle and per year.

M R I  Minimum Retreatment Interval ( days) ( at any rate). The minimum interval between pesticide application ( days).

R E I  ReEntry Interval  The minimum amount of time that must elapse before workers can reenter a treated area.

PHI/ PGI/ PSI Use Limitations ( May not apply to all Reg.# s)  Preharvest/ Pregrazing/ Preslaughter Interval use limitations pertinent to the application.

Current As Of:  The label data for the listed products in this report is current as of this date.

ABBREVIATIONS AN  As needed NA  Not Applicable NS  Not Specified ( on label)

( L)  The dosage information provided is from the label in terms of product ( e. g., ounces, gallons, or pounds of the product) because there was insufficient information ( e. g., missing density, area, or active ingredient percentages) to provide converted dosage information. This report provides active ingredient percentage in the product for the reported chemical for all unconverted label dosage information if this information is available. This active ingredient percentage information is displayed next to the form code abbreviations ( e. g., 80% WP).

UC  Unconverted due to lack of data ( on label).

APPLICATION RATE W : PPM calculated by weight V : PPM calculated by volume U : Unknown whether PPM is given by weight or by volume ~ : The dosage information includes a contribution from one or more ( TQ, CL, BR, I) active ingredients.

cwt : Hundred Weight nnE xx : nn times ( 10 power  xx), for instance, " 1.234E 04" is equivalent to ". 0001234"

FORMULATION CODES DF : Water Dispersible Granules ( dry Flowable)

FlC : Flowable Concentrate WP : Wettable Powder