Sethoxydim Dietary Exposure Assessment DP Barcode: D289880 PC Code: 121001 Page: 1 of 33 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D. C. 20460 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES MEMORANDUM DATE: 8/ 11/ 2003 SUBJECT: Sethoxydim. Acute Dietary Exposure Assessment for Section 3 Registration Actions.

PC Code: 121001 DP Barcode: D292905 REVIEWER: David Soderberg, Chemist Reregistration Branch 3 Health Effects Division ( 7509C)

THROUGH: David Miller, Senior Scientist David Hrdy, Chemist Douglas Dotson, Chemist Jennifer Tyler, Chemist Dietary Exposure Science Advisory Council ( DESAC)

Stephen Dapson, Branch Senior Scientist Registration Action Branch 3 Health Effects Division ( 7509C)

TO: Meta Bonner, Toxicologist Registration Action Branch 3 Health Effects Division ( 7509C)

Executive Summary The purpose of this memorandum is to report the results of an acute dietary exposure analysis for sethoxydim. This assessment updates and corrects the acute assessment reported in memorandum D289880, 6 May 2003. As was the case with D289880, the current assessment was performed in order to determine whether the exposure and risk estimates which result from the addition of lingonberry, juneberry, salal, pistachio, safflower, and sweet corn to the commodity residue list for sethoxydim resulted in dietary exposure to residues above HED's level of concern. The proposed tolerances are associated with Section 3 requests. Sethoxydim Dietary Exposure Assessment DP Barcode: D289880 PC Code: 121001 Page: 2 of 33 This acute assessment used tolerance level residues for most of the crops but limited refinement was obtained through the incorporation of field trial data and experimental processing factors for some of the crops expected to be more highly associated with dietary exposure to sethoxydim. Specifically, field trial data were incorporated for apples, pears and other pome fruits, grapes, oranges, potatoes, strawberries, peaches, succulent green peas, succulent green beans, and succulent lima beans. Empirical processing data for apples, grapes, tomatoes, potatoes and oranges were also used. The processing data for orange juice was also translated to other citrus juices. Percent crop treated information was available for most crops and was used wherever possible to refine the assessment. Tolerance level residues were used for meat. Poultry, milk and eggs.

[ Note that the chronic assessment presented in D289880 is refined in a somewhat different manner  through calculation of anticipated residues for meat and milk, and without using field trial data. The two different approaches for refinement resulted simply from differences in the exigencies of the logic between and acute and chronic dietary exposure assessments. One approach to refinement served the acute assessment better, and the other approach served the chronic assessment better.]

With the refinements incorporated in this assessment, the acute dietary analyses for sethoxydim result in estimated risks from acute dietary exposure to sethoxydim that are below the Agency's level of concern for the US population and all population subgroups listed in Summary Table 4. Exposure at the 99.9th percentile was 53% of the aPAD for the general US population, and 92% of the aPAD for children aged 1 2 years, and also children aged 3 5 years, the two most highly exposed population subgroup.

I. Introduction Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. The risk is expressed as a percentage of a maximum acceptable dose. This is the population adjusted dose ( PAD), which HED has concluded will result in no unreasonable adverse health effects. The PAD is the Reference Dose ( RfD) divided by the special FQPA Safety Factor. Dietary risk is expressed as a percentage of the PAD. For acute and non cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one in one million ( i. e., the risk exceeds 1 x 10 6). References which discuss the acute and chronic risk assessments in more detail are available on the EPA/ pesticides web site: " Available Information on Assessing Exposure from Pesticides, A User's Guide", 6/ 21/ 2000, web link: http:// www. epa. gov/ fedrgstr/ EPA PEST/ 2000/ July/ Day 12/ 6061. pdf ; or see SOP 99.6 ( 8/ 20/ 99). The most recent dietary risk assessment for sethoxydim was conducted by Manying Xue ( 7/ 13/ 01, D276182).

II. Residue Information Sethoxydim Use: Sethoxydim Dietary Exposure Assessment DP Barcode: D289880 PC Code: 121001 Page: 3 of 33 Tolerances are currently established ( 40 CFR § 180.412, attachment 2) on a variety of agricultural commodities at levels ranging from 0.2 ppm to 75.0 ppm and on meat, fat, and meat byproducts of cattle, goats, hogs, horses, poultry, and sheep at 0.2 ppm ( except 2.0 ppm in poultry, mbyp); eggs at 2.0 ppm, and milk at 0.05 ppm. Time limited tolerances ( to expire 12/ 31/ 03) are established on milk at 0.5 ppm and the meat byproducts of cattle, goats, hogs, horses, and sheep at 1.0 ppm. The tolerance expression for plant and livestock commodities includes the combined residues of sethoxydim and its metabolites containing the 2 cyclohexen 1 one moiety ( calculated as the herbicide) as specified in 40 CFR § 180.412.

The additional tolerances which have been proposed and are included in the current risk assessment are on lingonberry, juneberry, and salal at 5.0 ppm; pistachio at 0.2 ppm; safflower at 15.0 ppm; corn, sweet, kernels plus cob with husk removed at 0.4 ppm; corn, sweet, forage at 3.0 ppm; corn, sweet, stover at 3.5 ppm; milk at 0.5 ppm; and meat byproducts of cattle, goats, hogs, horses, and sheep at 1.0 ppm. Tolerances on fresh herbs ( except lemongrass) and tropical fruits have also been proposed but are not included in the current analyses because of data deficiencies.

Residue Data: Percent crop treated information was available for most crops and was therefore used wherever possible to refine the assessment. This acute analysis used tolerance level residues for most of the crops but some refinement was obtained through the incorporation of field trial data and experimental processing factors for some crops. These refinements were made for a minimum number of foods needed to obtain exposure results below HED's level of concern, which is 100% of the aPAD. Specifically, field trial data were incorporated for apples, pears and other pome fruits, grapes, oranges, potatoes, tomatoes, and strawberries. Empirical processing data for apples, grapes, tomatoes, potatoes and oranges were used, and were sometimes translated to other members of the crop group.

Tolerances were used for livestock commodities. BEAD provided maximum percent crop treated estimates. However, for poultry, pork and beef, goats and sheep, at least one feed item was assumed to be 100% crop treated, so although percent crop treated was theoretically incorporated into the livestock residue calculations, it was incorporated as 100%. For that reason RDF's were not created for livestock. Instead single point estimates of the residue values were used.

This assessment conformed closely to the assessment performed in D289880, except for refinement through the introduction of experimental data for some crops, and for the restructuring this acute assessment to conform with current HED policy for performing probabilistic acute dietary exposure assessments.

Adjustment factor 2 was not used in this assessment. Rather, for blended commodities the residue value is calculated from the tolerance times the percent crop treated. For partially blended or non blended commodities, where it is known or assumed that 100% of the crop is treated, the residue value consists of the tolerance with no adjustment for percent crop treated. For all other partially blended or non blended commodities RDFs were created that either incorporated Sethoxydim Dietary Exposure Assessment DP Barcode: D289880 PC Code: 121001 Page: 4 of 33 tolerances, or incorporated experimental residue data, with percent crop treated information. The RDF's used in this assessment are shown in attachment 3.

In addition to creation of RDFs based upon tolerances, field trial data were used to construct RDF's for apples, grapes, oranges, peaches, potatoes, strawberry, pears, succulent peas, succulent green beans, and succulent lima beans as follows.

Apples: MRID 40576101 provided residues for 14 field trials. Apples in these trials were treated at 1.5  2.5 lbs ai/ A/ year, with PHI's ranging from 7  19 days. The label rate is 1.4 lbs ai/ A/ year, with a PHI 14. These results were combined with an estimate of 1% crop treated to yield an RDF file consisting of the 14 field trial results and 1386 zeroes.

Grapes: MRID 43801410 provided residues for 6 field trials. Grapes in these trials were treated at 0.94 lbs ai/ A/ year, with a PHI of 50 days. The label rate is 0.94 lbs ai/ A/ year, with a PHI of 50 days. These results were combined with an estimate of 4% crop treated to yield an RDF file consisting of the 6 field trial results and 144 zeroes.

Oranges: MRID 40492601 provided 19 field trials. Of these, 6 field trials provided information for applications comparable to those specified on the labels. Oranges in the useful trials were treated at 2.0  3.0 lbs ai/ A/ year, with PHI 10  15 days. The label rate is 1.89 lbs ai/ A/ year, with PHI 15 days. This was combined with an estimate of 6% crop treated to yield an RDF file consisting of the 6 field trial results and 94 zeroes. Note that one of the trial results is the average ( 0.13 ppm) of multiple samples ( ranging from 0.1 ppm  0.25 ppm). Because the individual meaning of these multiple samples is not clear, it was decided to use the average despite applying it in an acute assessment.

Potato: MRID 43801407 provided residues for 9 field trials. Potatoes were treated at 0.94 lbs ai/ A/ year, with a PHI of 30 days. The label rate is 0.96 lbs ai/ A/ year, with a PHI of 30 days. This was combined with an estimate of 64% crop treated to yield an RDF file consisting of the 9 field trial results and 141 zeroes.

Strawberry: MRID 41342801 provided residues for 11 field trials. Strawberries were treated at 1.0 lbs ai/ A/ year, with a PHI of 7 days. The label rate is half that, 0.50 lbs ai/ A/ year, with a PHI of 7 days. The results of this study were combined with an estimate of 11% crop treated to yield an RDF file consisting of the 11 field trial results and 89 zeroes.

Pears: MRID 40576102 provided residues for 8 field trials. In 6 trials pears were treated at 1.5  2.0 lbs ai/ A/ year, with PHI 10  17 days. In 2 other trials pears were treated at 1.0 lbs ai/ A with 23  25 days PHI. All trials produced residues < 0.1 ppm. Because all results were 0.1 ppm, the results of the latter two trials were also used in the RDF, since rejecting them would have had no mathematical effect. The label rate is 1.4 lbs ai/ A/ year, with a PHI of 14 days. This was combined with an estimate of 1% crop treated to yield an RDF file consisting of the 8 field trial results and 792 zeroes. Sethoxydim Dietary Exposure Assessment DP Barcode: D289880 PC Code: 121001 Page: 5 of 33 Peaches: MRID 41236402 provided residues for 8 field trials. Peaches in six trials were treated at 1.0  1.5 lbs ai/ A/ year, with PHI 10  20 days. Peaches in 2 other trials were treated at 2.0 ai/ A/ year, with PHI of 62  89 days. These latter two trials were rejected. The label rate is 0.94 lbs ai/ A/ year, with PHI 25 days. All results were at 0.1 ppm. This was combined with an estimate of 1% crop treated to yield an RDF file consisting of one field trial result at 0.1 ppm and 99 zeroes.

Succulent Green Peas: MRID 43801415 provided residues for 7 field trials. Peas were treated at 0.75 lbs ai/ A/ year, with a PHI of 15 days. The label rate is 0.75 lbs ai/ A/ year, with a PHI of 15 days. This was combined with an estimate of 4% crop treated to yield an RDF file consisting of the 7 field trial results and 168 zeroes.

Succulent Green Beans: MRID 43801411 provided residues for 6 field trials. Beans were treated at 0.75 lbs ai/ A/ year, with a PHI of 15 days. The label rate is 0.75 lbs ai/ A/ year, with a PHI of 15 days. This was combined with an estimate of 10% crop treated to yield an RDF file consisting of the 6 field trial results and 54 zeroes.

Succulent Lima Beans: Residues for succulent lima beans were translated from the 6 residue values from succulent green bean RDF using an estimate of 12% crop treated to yield an RDF file consisting of the 6 field trial results and 44 zeroes.

Processing concentration/ reduction factors, DEEMTM default factors, which were used in the previous sethoxydim Dietary Exposure memo ( D289880), were also used in this assessment, except that experimental processing data were incorporated into the current assessment for grapes, apples, oranges, potatoes and tomatoes. Experimental processing data for orange juice were also translated to other citrus juices using ratios of DEEMTM default factors. The experimental processing data that were available to refine residues in processed commodities are as follows.

Tomatoes: MRID 92166080 provides processing factors for tomatoes to tomato juice ( 0.8) and tomato puree ( 1.2). A factor for tomato paste was calculated using the ratio of tomato paste/ tomato puree DEEMTM default factors times the experimental factor for tomato puree ( 1.2 * 5.4/ 3.3 = 1.96). No factor for dried tomatoes was determined in this study, so the DEEM default factor of 14.5 was used.

Potatoes: MRIDs 92166082 and 40195102 provide processing factors for potatoes to peeled potato ( 0.4), potato chips ( 0.9), potato flakes ( 1.8), potato granules 2.0.

Apples: MRIDs 92166087 and 40576103 provide processing factors for apples to peeled apples ( 0.7), apple juice ( 0.7), and apple sauce ( 0.4). A DEEMTM default factor of 8 was used for dried apples.

Grapes: MRID 43801416  provides processing factors for grapes to grape juice( 1.0 or less) and to raisins ( 3.0). Sethoxydim Dietary Exposure Assessment DP Barcode: D289880 PC Code: 121001 Page: 6 of 33 Oranges: MRID 92166086 and 40492605 provide processing factors for oranges to pulp ( 1.0) to peel ( 1.0), orange oil (< 1.0), juice < 1.0. The 1.0 factor was also translated to lemon peels. To translate juice factors, ratios of DEEMTM default factors were used. Thus lemon and lime juice were 1.0* 2/ 1.8 = 1.1), tangerine was 2.3/ 1.8 = 1.3 and grapefruit was 2.1/ 1.8 = 1.2)

III. DEEM FCID   Program and Consumption Information Sethoxydim acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database ( DEEMFCID   , Version 1.3), which incorporates consumption data from USDA's Continuing Surveys of Food Intakes by Individuals ( CSFII), 1994 1996 and 1998. The 1994 96, 98 data are based on the reported consumption of more than 20,000 individuals over two non consecutive survey days. Foods " as consumed" ( e. g., apple pie) are linked to EPA defined food commodities ( e. g. apples, peeled fruit  cooked; fresh or N/ S; baked; or wheat flour  cooked; fresh or N/ S, baked) using publicly available recipe translation files developed jointly by USDA/ ARS and EPA. Consumption data are averaged for the entire U. S. population and within population subgroups for chronic exposure assessment, but are retained as individual consumption events for acute exposure assessment.

For acute exposure assessments, individual one day food consumption data are used on an individual by individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic ( Tier 1 or Tier 2) exposure assessment, or " matched" in multiple random pairings with residue values and then summed in a probabilistic ( Tier 3/ 4) assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user ( i. e., those who reported eating relevant commodities/ food forms) and a per capita ( i. e., those who reported eating the relevant commodities as well as those who did not) basis.

IV. Toxicological Information On September 10, 1996, the Health Effects Division's Toxicology Endpoint Selection Committee ( TESC) selected the toxicological endpoints for acute dietary as well as occupational and residential exposure risk assessments ( TXR No. 013619).

On April 21, 1998, the Risk Assessment Review Committee ( RARC) reviewed the risk assessment document for sethoxydim. The RARC determined that a non developmental endpoint should be selected for acute dietary risk assessment for the General Population including Infants and Children since the developmental effects occur during in utero exposure and therefore are applicable only to the subpopulation Females 13+ but not for the Infants and Children. Sethoxydim Dietary Exposure Assessment DP Barcode: D289880 PC Code: 121001 Page: 7 of 33 On April 30, 1998, the Hazard Identification Assessment Review Committee ( HIARC) met and selected a non developmental endpoint for the acute dietary risk assessment for the General Population including Infants and Children ( TXR No. 012602).

On July 16, 2002 and December 17, 2002, the Health Effects Division ( HED) Hazard Identification Assessment Review Committee ( HIARC) reevaluated the toxicology endpoint selection for sethoxydim with regard to the acute and chronic Reference Doses ( RfDs) and for use as appropriate in occupational/ residential exposure risk assessments. The potential for increased susceptibility of infants and children from exposure to sethoxydim was also evaluated as required by the Food Quality Protection Act ( FQPA) of 1996 according to the 2002 OPP 10x Guidance Document.

The HIARC concluded on July 16, 2002 and December 17, 2002 that the toxicology database for sethoxydim is adequate to evaluate the hazard and exposure data for sethoxydim and recommend application of an FQPA Safety Factor ( for enhanced sensitivity of infants and children as required by the Food Quality Protection Act of 1996) to ensure the protection of infants and children from exposure to this chemical. Acceptable developmental toxicity studies have been performed in rats and rabbits, with evidence of neurotoxicity in the rat study; and an acceptable two generation reproduction study has also been performed in rats. No neurotoxicity studies were submitted ( acute, subchronic, or developmental).

The HIARC concluded that there is a concern for developmental neurotoxicity resulting from exposure to sethoxydim and recommended that this study be conducted. In accordance with the 2002, OPP Guidance Document on Determination of the Appropriate FQPA Safety Factor( s) in Tolerance Assessment, the HIARC concluded that a Database Uncertainty Factor of 10X is required for lack of subchronic and developmental neurotoxicity studies.

Since there is evidence of increased susceptibility of the young following exposure to sethoxydim in the rat developmental and in the two generation reproduction studies in rats, the HIARC performed a Degree of Concern Analysis to: 1) determine the level of concern for the effects observed when considered in the context of all available toxicity data; and 2) identify any residual uncertainties after establishing toxicity endpoints and traditional uncertainty factors to be used in the risk assessment. The HIARC determined that the special FQPA Safety Factor is 1X since there are no residual uncertainties for pre and/ or post natal toxicity.

The toxicological doses and endpoints for dietary exposure scenarios are summarized in Table 1. Sethoxydim Dietary Exposure Assessment DP Barcode: D289880 PC Code: 121001 Page: 8 of 33 Table 1. Summary of Toxicological Doses and Endpoints for Sethoxydim for Use in Dietary Exposure Assessment Exposure Scenario Dose Used in Risk Assessment, UF Special FQPA SF* and Level of Concern for Risk Assessment Study and Toxicological Effects Acute Dietary ( Females 13 50 years of age) NOAEL = 180 mg/ kg/ day UF = 1000 Acute RfD = 0.18 mg/ kg/ day FQPA SF = 1X aPAD = acute RfD FQPA SF = 0.18 mg/ kg/ day Rat Developmental Toxicity Developmental LOAEL = 650 mg/ kg/ day based on decreased fetal body weight, tail abnormalities, delayed ossification.

Acute Dietary ( General population including infants and children) NOAEL = 180 mg/ kg/ day UF = 1000 Acute RfD = 0.18 mg/ kg/ day FQPA SF = 1X aPAD = acute RfD FQPA SF = 0.18 mg/ kg/ day Rat Developmental Toxicity Maternal LOAEL = 650 mg/ kg/ day based on irregular gait that was observed in 12/ 34 damson the first day of dosing.

Chronic Dietary ( All populations) NOAEL= 14 mg/ kg/ day UF = 1000 Chronic RfD = 0.014 mg/ kg/ day FQPA SF = 1X cPAD = chronic RfD FQPA SF = 0.014 mg/ kg/ day Mouse Carcinogenicity Study LOAEL = 41 mg/ kg/ day based on liver hypertrophy and fatty degeneration.

Cancer Not a likely human carcinogen based on the lack of evidence of carcinogenicity in rats and mice.

UF = uncertainty factor, FQPA SF = FQPA safety factor, NOAEL = no observed adverse effect level, LOAEL = lowest observed adverse effect level, PAD = population adjusted dose ( a = acute, c = chronic), RfD = reference dose V. Results/ Discussion As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM FCID   analyses estimate the dietary exposure of the U. S. population and 32 population subgroups. The results reported in Tables 2 and 3 are for the general U. S. Population, all infants (< 1 year old), children 1 2, children 3 5, children 6 12, youth 13 19, females 13 49, adults 20 49, and adults 50+ years.

Acute exposure results are reported at the 99.9th percentile of exposure because the assessment incorporated estimates of % CT, and some field trial data and some experimental processing data introduce limited refinements to make this a Tier 3 assessment. Sethoxydim Dietary Exposure Assessment DP Barcode: D289880 PC Code: 121001 Page: 9 of 33 Table 2. Results of Acute Dietary Exposure Analysis Population Subgroup aPAD ( mg/ kg/ day) 95th Percentile 99th Percentile 99.9th Percentile Exposure ( mg/ kg/ day) % aPAD Exposure ( mg/ kg/ day) % aPAD Exposure ( mg/ kg/ day) % aPAD General U. S. Population 0.18 0.028269 16 0.051716 29 0.096005 53 All Infants (< 1 year old) 0.18 0.057547 32 0.089248 50 0.133483 74 Children 1 2 years old 0.18 0.068536 38 0.097957 54 0.164984 92 Children 3 5 years old 0.18 0.050490 28 0.076845 43 0.164777 92 Children 6 12 years old 0.18 0.032804 18 0.051966 29 0.118367 66 Youth 13 19 years old 0.18 0.020769 12 0.035623 20 0.078228 43 Adults 20 49 years old 0.18 0.016329 9.1 0.028731 16 0.071655 40 Females 13 49 years old 0.18 0.016241 9.0 0.027724 15 0.074049 41 Adults 50+ years old 0.18 0.015650 8.7 0.028086 16 0.062645 35 Comment: The acute dietary risk estimates are below the Agency's level of concern (< 100% aPAD) for the general U. S. population and all population subgroups listed in Table 2. The most highly exposed subpopulations were children aged 1 2 and children aged 3 5 years, both at 92% of the aPAD.

VI. Discussion of Uncertainties This acute assessment used tolerance level residues and the percent crop treated for most crops. Monitoring data from the pesticide Data program or from the Food And Drug Administration are not available for sethoxydim, however, experimental field trial data are available and were introduced into this assessment for a limited number of foods. The concentration/ reduction factors which were used in the previous Dietary Exposure memo ( D289880) were generally also used in this assessment, but, experimental processing data was also introduced for a limited number of crops.

Those crop for which processing data or field trial data were introduced into this assessment are expected to be among those contributing most sethoxydim exposure. However, field trial data exist for other crops, and some additional processing data may also be available. Therefore, the input data to HED's exposure and risk estimates could potentially be further refined with existing additional field trial data and/ or processing data for additional crops. However, dietary exposure to sethoxydim is not through just one or two foods, but is spread out over the very many different foods it is used on. Thus, it may be that additional refinement of input data for some few more foods into the DEEM FCID model will not result in a corresponding decrease in anticipated risk estimated by that model. On the other hand, use of field trial data to estimate residues in foods is Sethoxydim Dietary Exposure Assessment DP Barcode: D289880 PC Code: 121001 Page: 10 of 33 known to be very conservative relative to use of monitoring data, or market basket data to estimate residues in those same foods. Thus it is likely that, were monitoring data available for sethoxydim in foods, the dietary exposure estimates for sethoxydim would be considerably lower than those projected here.

VII. Conclusions The acute and chronic dietary risk assessments were conducted for all supported sethoxydim food uses. For all supported registered commodities, the acute risk estimates are below the Agency's level of concern at the 99.9th exposure percentile for the general U. S. population ( 52% of the aPAD), 92% for children aged 1 2 years and also for children aged 3 5 years.

VIII. List of Attachments 1. BEAD % CT Information 2. 40 CFR § 180.412 dated 4/ 24/ 03 3. Acute Residue Assessment Results for Sethoxydim 4. Acute Residue Input Data for DEEMTM Analysis 5. RDFs for the Acute Residue DEEMTM Analysis cc: D. Soderberg, M. Bonner, D. Hrdy, D. Miller, J. Tyler, D. Dotson, C. Eiden, N. Dodd, RDI: RRB3 Attachment 1.

Page 1 of 2 SETHOXYDIM PERCENT CROP TREATED ( PCT) ESTIMATES FOR CROPS SELECTED BY HED Alan Halvorson, BEAD/ EAB, 3/ 26/ 03 Avg PCT Max PCT Apples 0.1 0.3 Beans, Lima 9 12 Beans, Snap 8 10 Beans/ Peas, Dry 14 18 Corn, Field 0.1 0.3 Peanuts 5 16 Pears 0.03 0.3 Peas, Green 2 4 Potatoes 4 6 Safflower ? ? Soybeans 2 9 Squash 8 11 Sugarbeets 8 28 Sunflowers 14 21 Tomatoes 4 6 Note  Information from the registrant needed for safflower estimates.

Sources    USDA, 1991  2001  EPA proprietary data, 1996  2001 ATTACHMENT 1 Page 2 of 2 SETHOXYDIM PERCENT CROP TREATED ( PCT) ESTIMATES FOR OTHER CROPS SELECTED BY HED Alan Halvorson, BEAD/ EAB, 4/ 14/ 03 Avg PCT Max PCT Alfalfa 1 3 Apricot 0.02 0.2 Asparagus 5 8 Broccoli 1 3 Cabbage 5 8 Canola/ Rapeseed 4 8 Cantaloupe 8 13 Carrots 2 5 Cauliflower 2 5 Cherries 0.4 2 Collards 2 5 Cotton 0.5 3 Cranberries(#) 8 12 Cucumber 6 15 Eggplant/ Peppers(#) 5 10 Flax(#) 38 55 Grapefruit 1 4 Grapes 1 4 Lemons 5 10 Lettuce 1 3  Lettuce, Head 1 3  Lettuce, Other 1 3 Nectarines 0.1 1 Oranges 3 6 Peaches 0.4 1 Peppers 6 17  Peppers, Bell 3 7  Peppers, Chili 11 20 Pumpkin 8 11 Roots/ Tubers(#,*) 5 10 Spinach 0.3 1 Strawberries 5 11 Sweet Corn 0.5 2 Sweet Potatoes(#) 18 24 Vegetables, Other(#,**) 6 15 Watermelon 12 20 (#) Data exclude years after 1997 and thus estimates may not be very reliable. (*) Includes beets, carrots, horseradish, parsnips, radish, rutabagas, sweet potatoes, turnips and yams. (**) Includes artichokes, asparagus, okra, oriental vegetables, rhubarb and truck farm.

Sources   USDA, 1991  2001  EPA proprietary data, 1996  2001  CA 1998  2000  NCFAP circa 1997 & before Attachment 2. 40 CFR 180.412 Tolerances Page 1 of 3 40 CFR  CHAPTER I  PART 180 180.412 Sethoxydim; tolerances for residues. ( a) General. Tolerances are established for combined residues of the herbicide 2[ 1( ethoxyimino) butyl] 5[ 2( ethylthio) propyl] 3 hydroxy 2 cyclohexen 1 one ( CAS Reg. No. 74051 80 2) and its metabolites containing the 2 cyclohexen 1 one moiety ( calculated as the herbicide) in or on the following commodities:

Expiration/ Commodity Parts per Revocation million Date   Alfalfa, forage................................. 40.0 None Alfalfa, hay.................................... 40.0 None Almond, hulls................................... 2.0 None Apple, dry pomace............................... 0.8 None Apple, wet pomace............................... 0.8 None Apricot......................................... 0.2 None Asparagus....................................... 4.0 None Bean, dry....................................... 20.0 None Bean, forage.................................... 15.0 None Bean, hay....................................... 50.0 None Bean, succulent................................. 15.0 None Beet, garden.................................... 1.0 None Beet, sugar, molasses........................... 10.0 None Beet, sugar, roots.............................. 1.0 None Beet, sugar, tops............................... 3.0 None Blueberry....................................... 4.0 None Caneberries subgroup............................ 5.0 None Canola/ rapeseed................................. 35.0 None Canola/ rapeseed, meal........................... 40.0 None Carrot.......................................... 1.0 None Cattle, fat..................................... 0.2 None Cattle, meat byproducts......................... 0.2 None Cattle, meat.................................... 0.2 None Cherry, sweet................................... 0.2 None Cherry, tart.................................... 0.2 None Cilantro........................................ 4.0 None Citrus, molasses................................ 1.5 None Citrus, dried pulp.............................. 1.5 None Clover, forage.................................. 35.0 None Clover, hay..................................... 50.0 None Cotton, seed, soapstock.......................... 15 None Corn, field, grain.............................. 0.5 None Corn fodder..................................... 2.5 None Corn forage..................................... 2.0 None Corn, sweet, kernel plus cob with husks removed. 0.2 None Cranberry....................................... 2.0 None Cottonseed...................................... 5.0 None Egg............................................. 2.0 None Flaxseed........................................ 5.0 None Flaxseed meal................................... 7 None Flax, straw..................................... 2.0 None Fruit, citrus................................... 0.5 None Fruit, pome..................................... 0.2 None Goat, fat....................................... 0.2 None Goat, meat byproducts........................... 0.2 None Goat, meat...................................... 0.2 None Grape........................................... 1.0 None Hog, fat........................................ 0.2 None Hog, meat byproducts............................ 0.2 None Hog, meat....................................... 0.2 None Horseradish..................................... 4.0 None Horse, fat...................................... 0.2 None Horse, meat byproducts.......................... 0.2 None Horse, meat..................................... 0.2 None Leafy vegetable ( except Brassica) crop group.... 4.0 None Lentils......................................... 30.0 None Milk............................................ 0.05 ( N) None Nectarine....................................... 0.2 None Peach........................................... 0.2 None Peanut.......................................... 25.0 None Peanut, soapstock............................... 75.0 None Pea, dry........................................ 40.0 None Pea, forage..................................... 20.0 None Pea, hay........................................ 40.0 None Pea, succulent.................................. 10.0 None Peppermint, tops ( stems and leaves)............. 30.0 None Potato flakes................................... 8.0 None Potato granules................................. 8.0 None Potato waste, processed ( wet and dry)........... 8.0 None Poultry, fat.................................... 0.2 None Poultry, meat byproducts........................ 2.0 None Poultry, meat................................... 0.2 None Raisins......................................... 2.0 None Sheep, fat...................................... 0.2 None Sheep, meat byproducts.......................... 0.2 None Sheep, meat..................................... 0.2 None Soybean, hay.................................... 10.0 None Soybean......................................... 16.0 None Spearmint, tops ( stems and leaves).............. 30.0 None Strawberry...................................... 10.0 None Sunflower meal.................................. 20.0 None Sunflower, seed................................. 7.0 None Tomato, concentrated products................... 24 None Tomato, dry pomace.............................. 12.0 None Tree nut........................................ 0.2 None Tuberous and corm vegetable crop subgroup....... 4.0 None Vegetable, brassica, leafy, group............... 5.0 None Vegetable, bulb, group.......................... 1.0 None Vegetable, cucurbit, group...................... 4.0 None Vegetable, fruiting............................. 4.0 None

( b) Section 18 emergency exemptions. A time limited tolerance is established for combined residues of the herbicide sethoxydim and its metabolites containing the 2 cyclohexen 1 one moiety, calculated as the herbicide in connection with use of the pesticide under section 18 emergency exemptions granted by EPA. This tolerance will expire and is revoked on the date specified in the following table:

Expiration/ Commodity Parts per revocation million date   Cattle, meat byproducts......................... 1.0 12/ 31/ 03 Goat, meat byproducts........................... 1.0 12/ 31/ 03 Hog, meat byproducts............................ 1.0 12/ 31/ 03 Horse, meat byproducts.......................... 1.0 12/ 31/ 03 Milk............................................ 0.5 12/ 31/ 03 Safflower....................................... 15.0 12/ 31/ 03 Sheep, meat byproducts.......................... 1.0 12/ 31/ 03

( c) Tolerances with regional registration. Tolerances with regional registration, as defined in Section 180.1( n), are established for the combined residues of the herbicide 2[ 1( ethoxyimino) butyl] 5[ 2( ethylthio) propyl] 3 hydroxy 2 cyclohexen 1 on e) and its metabolites containing the 2 cyclohexen 1 one moiety ( calculated as the herbicide) in or on the following commodities:

Expiration/ Commodity Parts per Revocation million Date   Artichoke, globe................................ 5.0 None Rhubarb......................................... 0.3 None

( d) Indirect and inadvertent residues. [ Reserved] [ 62 FR 17740, Apr. 11, 1997, as amended at 62 FR 44565, Aug. 22, 1997; 63 FR 54073, Oct. 8, 1998; 64 FR 32196, June 16, 1999; 64 FR 56703, Oct. 21, 1999; 66 FR 51594, Oct. 10, 2001; 66 FR 65452, Dec. 19, 2001; 67 FR 35048, May 17, 2002; 67 FR 41807, June 19, 2002; 67 FR 42397, June 21, 2002] ATTACHMENT 3 Results of Acute Dietary Exposure Assessment U. S. Environmental Protection Agency Ver. 1.33 DEEM FCID ACUTE Analysis for SETHOXYDIM ( 1994 98 data) Residue file: sethacFTlast2. R98 Adjustment factor # 2 NOT used. Analysis Date: 08 19 2003/ 12: 16: 57 Residue file dated: 08 18 2003/ 18: 34: 22/ 8 NOEL ( Acute) = 180.000000 mg/ kg body wt/ day Daily totals for food and foodform consumption used. MC iterations = 1000 MC list in residue file MC seed = 10 Run Comment: " UF ( both chronic and acute) = 1000; FQPA = 1X" ===============================================================================

Summary calculations ( per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE          U. S. Population: 0.028269 15.70 6367 0.051716 28.73 3480 0.096005 53.34 1874 All infants: 0.057547 31.97 3127 0.089248 49.58 2016 0.133483 74.16 1348 Children 1 2 yrs: 0.068536 38.08 2626 0.097957 54.42 1837 0.164984 91.66 1091 Children 3 5 yrs: 0.050490 28.05 3565 0.076845 42.69 2342 0.164777 91.54 1092 Children 6 12 yrs: 0.032804 18.22 5487 0.051966 28.87 3463 0.118367 65.76 1520 Youth 13 19 yrs: 0.020769 11.54 8666 0.035623 19.79 5052 0.078228 43.46 2300 Adults 20 49 yrs: 0.016329 9.07 11023 0.028731 15.96 6264 0.071655 39.81 2512 Adults 50+ yrs: 0.015650 8.69 11501 0.028086 15.60 6408 0.062645 34.80 2873 Females 13 49 yrs: 0.016241 9.02 11082 0.027724 15.40 6492 0.074049 41.14 2430 Attachment 4.

U. S. Environmental Protection Agency Ver. 1.33 DEEM FCID Acute analysis for SETHOXYDIM Residue file name: C:\ soderberg\ My Documents\ sethoxydim\ sethacFTlast2. R98 Analysis Date 08 19 2003 Residue file dated: 08 18 2003/ 18: 34: 22/ 8 Reference dose: aRfD = 0.18 mg/ kg bw/ day NOEL = 180 mg/ kg bw/ day Comment: UF ( both chronic and acute) = 1000; FQPA = 1X  RDL indices and parameters for Monte Carlo Analysis: Index Dist Parameter # 1 Param # 2 Param # 3 Comment # Code       1 6 sethapplesFT. RDF 2 6 sethstonefruits. RDF 3 6 sethcherry. RDF 4 6 sethgrapesFT. RDF 5 6 sethlgrapefruits. RDF 6 6 sethlemons. RDF 7 6 sethorangesFT. RDF 8 6 sethpotatoFT. RDF 9 6 sethpeachesFT. RDF 10 6 strawberriesFT. RDF 11 6 sethasparagus. RDF 12 6 sethcarrots. RDF 13 6 sethcranberry. RDF 14 6 sethlettuce. RDF 15 6 sethspinach. RDF 16 6 sethsweets. RDF 17 6 sethtomato. RDF 18 6 sethbellpeppers. RDF 19 6 sethchilipep. RDF 20 6 sethcucumber. RDF 21 6 setheggplant. RDF 22 6 sethokra. RDF 23 6 sethgreenbeansFT. RDF 24 6 sethcantaloupe. RDF 25 6 sethpumpksquash. RDF 26 6 sethwatermelon. RDF 27 6 sethbroccoli. RDF 28 6 sethcabbage. RDF 29 6 sethcauliflower. RDF 30 6 sethglobeartichoke. RDF 31 6 sethjerusalemartichoke. RDF 32 6 sethgardenbeetroots. RDF 33 6 sethgardenbeettops. RDF 34 6 sethpeanut. RDF 35 6 sethrhubarb. RDF 36 6 sethtomatotree. RDF 37 6 sethturnipgreens. RDF 38 6 sethyams. RDF 39 6 sethpearsFT. RDF 40 6 sethgreenpeasFT. RDF 41 6 sethgreenbeanslimaFT. RDF EPA Crop Food Name Def Res Adj. Factors RDL Comment Code Grp ( ppm) # 1 # 2 Pntr         14000030 14 Almond 0.200000 1.000 1.000 100% C Full comment: 100% CT 14000031 14 Almond babyfood 0.200000 1.000 1.000 100% C Full comment: 100% CT 14000040 14 Almond, oil 0.200000 1.000 1.000 100% C Full comment: 100% CT 14000041 14 Almond, oil babyfood 0.200000 1.000 1.000 100% C Full comment: 100% CT 04010050 4A Amaranth, leafy 4.000000 1.000 1.000 11000070 11 Apple, fruit with peel 0.200000 1.000 1.000 1 11000080 11 Apple, peeled fruit 0.200000 0.700 1.000 1 11000081 11 Apple, peeled fruit babyfood 0.200000 0.700 1.000 1 11000090 11 Apple, dried 0.200000 8.000 1.000 1 11000091 11 Apple, dried babyfood 0.200000 8.000 1.000 1 11000100 11 Apple, juice 0.200000 0.700 1.000 1 11000101 11 Apple, juice babyfood 0.200000 0.700 1.000 1 11000110 11 Apple, sauce 0.200000 0.400 1.000 1 11000111 11 Apple, sauce babyfood 0.200000 0.400 1.000 1 12000120 12 Apricot 0.200000 1.000 1.000 2 12000121 12 Apricot babyfood 0.200000 1.000 1.000 2 12000130 12 Apricot, dried 0.200000 6.000 1.000 2 12000140 12 Apricot, juice 0.200000 1.000 1.000 2 12000141 12 Apricot, juice babyfood 0.200000 1.000 1.000 2 01030150 1CD Arrowroot, flour 4.000000 1.000 1.000 01030151 1CD Arrowroot, flour babyfood 4.000000 1.000 1.000 95000160 O Artichoke, globe 5.000000 1.000 1.000 30 01030170 1CD Artichoke, Jerusalem 4.000000 1.000 1.000 31 04010180 4A Arugula 4.000000 1.000 1.000 95000190 O Asparagus 4.000000 1.000 1.000 11 09020210 9B Balsam pear 4.000000 1.000 1.000 06030300 6C Bean, black, seed 3.600000 1.000 1.000 06020310 6B Bean, broad, succulent 15.000000 1.000 1.000 41 5CT? 06030320 6C Bean, broad, seed 3.600000 1.000 1.000 06020330 6B Bean, cowpea, succulent 15.000000 1.000 1.000 41 5CT? 06030340 6C Bean, cowpea, seed 3.600000 1.000 1.000 06030350 6C Bean, great northern, seed 3.600000 1.000 1.000 06030360 6C Bean, kidney, seed 3.600000 1.000 1.000 06020370 6B Bean, lima, succulent 1.800000 1.000 1.000 41 06030380 6C Bean, lima, seed 3.600000 1.000 1.000 06030390 6C Bean, mung, seed 3.600000 1.000 1.000 06030400 6C Bean, navy, seed 3.600000 1.000 1.000 06030410 6C Bean, pink, seed 3.600000 1.000 1.000 06030420 6C Bean, pinto, seed 3.600000 1.000 1.000 06010430 6A Bean, snap, succulent 1.500000 1.000 1.000 23 06010431 6A Bean, snap, succulent babyfood 1.500000 1.000 1.000 23 21000440 M Beef, meat 0.200000 1.000 1.000 21000441 M Beef, meat babyfood 0.200000 1.000 1.000 21000450 M Beef, meat, dried 0.200000 1.920 1.000 21000460 M Beef, meat byproducts 1.000000 1.000 1.000 21000461 M Beef, meat byproducts babyfood 1.000000 1.000 1.000 21000470 M Beef, fat 0.200000 1.000 1.000 21000471 M Beef, fat babyfood 0.200000 1.000 1.000 21000480 M Beef, kidney 1.000000 1.000 1.000 21000490 M Beef, liver 1.000000 1.000 1.000 21000491 M Beef, liver babyfood 0.200000 1.000 1.000 01010500 1AB Beet, garden, roots 1.000000 1.000 1.000 32 01010501 1AB Beet, garden, roots babyfood 1.000000 1.000 1.000 32 02000510 2 Beet, garden, tops 3.000000 1.000 1.000 33 01010520 1A Beet, sugar 0.280000 1.000 1.000 01010521 1A Beet, sugar babyfood 0.280000 1.000 1.000 01010530 1A Beet, sugar, molasses 2.800000 1.000 1.000 01010531 1A Beet, sugar, molasses babyfood 2.800000 1.000 1.000 13010550 13A Blackberry 5.000000 1.000 1.000 100% C Full comment: 100% CT 13010560 13A Blackberry, juice 5.000000 1.000 1.000 100% C Full comment: 100% CT 13010561 13A Blackberry, juice babyfood 5.000000 1.000 1.000 100% C Full comment: 100% CT 13020570 13B Blueberry 4.000000 1.000 1.000 100% C Full comment: 100% CT 13020571 13B Blueberry babyfood 4.000000 1.000 1.000 100% C Full comment: 100% CT 13010580 13A Boysenberry 5.000000 1.000 1.000 100% C Full comment: 100% CT 14000590 14 Brazil nut 0.200000 1.000 1.000 100% C Full comment: 100% CT 05010610 5A Broccoli 5.000000 1.000 1.000 27 05010611 5A Broccoli babyfood 5.000000 1.000 1.000 27 05010620 5A Broccoli, Chinese 5.000000 1.000 1.000 27 05020630 5B Broccoli raab 5.000000 1.000 1.000 05010640 5A Brussels sprouts 5.000000 1.000 1.000 14000680 14 Butternut 0.200000 1.000 1.000 100% C Full comment: 100% CT 05010690 5A Cabbage 5.000000 1.000 1.000 28 05020700 5B Cabbage, Chinese, bok choy 5.000000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 5.000000 1.000 1.000 28 05010720 5A Cabbage, Chinese, mustard 5.000000 1.000 1.000 27 09010750 9A Cantaloupe 4.000000 1.000 1.000 24 04020760 4B Cardoon 4.000000 1.000 1.000 01010780 1AB Carrot 1.000000 1.000 1.000 12 09010800 9A Casaba 4.000000 1.000 1.000 14000810 14 Cashew 0.200000 1.000 1.000 100% C Full comment: 100% CT 01030820 1CD Cassava 4.000000 1.000 1.000 01030821 1CD Cassava babyfood 4.000000 1.000 1.000 05010830 5A Cauliflower 5.000000 1.000 1.000 29 04020850 4B Celery 4.000000 1.000 1.000 04020851 4B Celery babyfood 4.000000 1.000 1.000 04020860 4B Celery, juice 4.000000 1.000 1.000 04020870 4B Celtuce 4.000000 1.000 1.000 09020880 9B Chayote, fruit 4.000000 1.000 1.000 12000900 12 Cherry 0.200000 1.000 1.000 3 12000901 12 Cherry babyfood 0.200000 1.000 1.000 3 12000910 12 Cherry, juice 0.200000 1.500 1.000 3 12000911 12 Cherry, juice babyfood 0.200000 1.500 1.000 3 14000920 14 Chestnut 0.200000 1.000 1.000 100% C Full comment: 100% CT 40000930 P Chicken, meat 0.200000 1.000 1.000 40000931 P Chicken, meat babyfood 0.200000 1.000 1.000 40000940 P Chicken, liver 2.000000 1.000 1.000 40000950 P Chicken, meat byproducts 2.000000 1.000 1.000 40000951 P Chicken, meat byproducts babyfoo 2.000000 1.000 1.000 40000960 P Chicken, fat 0.200000 1.000 1.000 40000961 P Chicken, fat babyfood 0.200000 1.000 1.000 40000970 P Chicken, skin 2.000000 1.000 1.000 40000971 P Chicken, skin babyfood 2.000000 1.000 1.000 06030980 6C Chickpea, seed 7.200000 1.000 1.000 06030981 6C Chickpea, seed babyfood 7.200000 1.000 1.000 09021020 9B Chinese waxgourd 4.000000 1.000 1.000 04011040 4A Chrysanthemum, garland 4.000000 1.000 1.000 10001060 10 Citrus citron 0.500000 1.000 1.000 100% Full comment: 100% CT 10001070 10 Citrus hybrids 0.500000 1.000 1.000 100% Full comment: 100% CT 10001080 10 Citrus, oil 0.500000 1.000 1.000 100% Full comment: 100% CT 05021170 5B Collards 5.000000 1.000 1.000 29 caulif Full comment: cauliflower has same tol/% CT 19011180 19A Coriander, leaves 4.000000 1.000 1.000 19011181 19A Coriander, leaves babyfood 4.000000 1.000 1.000 19021190 19B Coriander, seed 4.000000 1.000 1.000 19021191 19B Coriander, seed babyfood 4.000000 1.000 1.000 15001200 15 Corn, field, flour 0.050000 1.000 1.000 15001201 15 Corn, field, flour babyfood 0.050000 1.000 1.000 15001210 15 Corn, field, meal 0.050000 1.000 1.000 15001211 15 Corn, field, meal babyfood 0.050000 1.000 1.000 15001220 15 Corn, field, bran 0.050000 1.000 1.000 15001230 15 Corn, field, starch 0.050000 1.000 1.000 15001231 15 Corn, field, starch babyfood 0.050000 1.000 1.000 15001240 15 Corn, field, syrup 0.050000 1.500 1.000 15001241 15 Corn, field, syrup babyfood 0.050000 1.500 1.000 15001250 15 Corn, field, oil 0.050000 1.000 1.000 15001251 15 Corn, field, oil babyfood 0.050000 1.000 1.000 15001270 15 Corn, sweet 0.400000 1.000 1.000 95001280 O Cottonseed, oil 0.150000 1.000 1.000 95001281 O Cottonseed, oil babyfood 0.150000 1.000 1.000 11001290 11 Crabapple 0.200000 1.000 1.000 1 95001300 O Cranberry 2.000000 1.000 1.000 13 04011330 4A Cress, garden 4.000000 1.000 1.000 04011340 4A Cress, upland 4.000000 1.000 1.000 09021350 9B Cucumber 4.000000 1.000 1.000 20 04011380 4A Dandelion, leaves 4.000000 1.000 1.000 01031390 1CD Dasheen, corm 4.000000 1.000 1.000 13011420 13A Dewberry 5.000000 1.000 1.000 100% C Full comment: 100% CT 70001450 P Egg, whole 2.000000 1.000 1.000 70001451 P Egg, whole babyfood 2.000000 1.000 1.000 70001460 P Egg, white 2.000000 1.000 1.000 70001461 P Egg, white ( solids) babyfood 2.000000 1.000 1.000 70001470 P Egg, yolk 2.000000 1.000 1.000 70001471 P Egg, yolk babyfood 2.000000 1.000 1.000 08001480 8 Eggplant 4.000000 1.000 1.000 21 04011500 4A Endive 4.000000 1.000 1.000 04021520 4B Fennel, Florence 4.000000 1.000 1.000 14001550 14 Filbert 0.200000 1.000 1.000 100% C Full comment: 100% CT 14001560 14 Filbert, oil 0.200000 1.000 1.000 100% C Full comment: 100% CT 20001630 20 Flaxseed, oil 2.750000 1.000 1.000 03001640 3 Garlic 1.000000 1.000 1.000 100% C Full comment: 100% CT 03001650 3 Garlic, dried 1.000000 1.000 1.000 100% C Full comment: 100% CT 03001651 3 Garlic, dried babyfood 1.000000 1.000 1.000 100% C Full comment: 100% CT 01031660 1CD Ginger 4.000000 1.000 1.000 01031661 1CD Ginger babyfood 4.000000 1.000 1.000 01031670 1CD Ginger, dried 4.000000 1.000 1.000 23001690 M Goat, meat 0.200000 1.000 1.000 23001700 M Goat, meat byproducts 1.000000 1.000 1.000 23001710 M Goat, fat 0.200000 1.000 1.000 23001720 M Goat, kidney 1.000000 1.000 1.000 23001730 M Goat, liver 1.000000 1.000 1.000 95001750 O Grape 1.000000 1.000 1.000 4 95001760 O Grape, juice 1.000000 1.000 1.000 4 95001761 O Grape, juice babyfood 1.000000 1.000 1.000 4 95001770 O Grape, leaves 1.000000 1.000 1.000 4 95001780 O Grape, raisin 2.000000 3.000 1.000 4 95001790 O Grape, wine and sherry 1.000000 1.000 1.000 4 10001800 10 Grapefruit 0.500000 1.000 1.000 5 10001810 10 Grapefruit, juice 0.500000 1.200 1.000 5 14001850 14 Hickory nut 0.200000 1.000 1.000 100% C Full comment: 100% CT 09011870 9A Honeydew melon 4.000000 1.000 1.000 24001890 M Horse, meat 0.200000 1.000 1.000 01011900 1AB Horseradish 4.000000 1.000 0.100 05021940 5B Kale 5.000000 1.000 1.000 05011960 5A Kohlrabi 5.000000 1.000 1.000 10001970 10 Kumquat 0.500000 1.000 1.000 100% Full comment: 100% CT 03001980 3 Leek 1.000000 1.000 1.000 100% C Full comment: 100% CT 10001990 10 Lemon 0.500000 1.000 1.000 6 10002000 10 Lemon, juice 0.500000 1.100 1.000 6 10002001 10 Lemon, juice babyfood 0.500000 1.100 1.000 6 10002010 10 Lemon, peel 0.500000 1.000 1.000 6 06032030 6C Lentil, seed 30.000000 1.000 1.000 04012040 4A Lettuce, head 4.000000 1.000 1.000 14 04012050 4A Lettuce, leaf 4.000000 1.000 1.000 14 10002060 10 Lime 0.500000 1.000 1.000 100% C Full comment: 100% CT 10002070 10 Lime, juice 0.500000 1.100 1.000 100% C Full comment: 100% CT 10002071 10 Lime, juice babyfood 0.500000 1.100 1.000 100% C Full comment: 100% CT 13012080 13A Loganberry 5.000000 1.000 1.000 100% C Full comment: 100% CT 11002100 11 Loquat 0.200000 1.000 1.000 39 100% C Full comment: 100% CT 14002130 14 Macadamia nut 0.200000 1.000 1.000 100% C Full comment: 100% CT 27002220 D Milk, fat 0.500000 1.000 1.000 27002221 D Milk, fat  baby food/ infant for 0.500000 1.000 1.000 27012230 D Milk, nonfat solids 0.500000 1.000 1.000 27012231 D Milk, nonfat solids baby food/ in 0.500000 1.000 1.000 27022240 D Milk, water 0.500000 1.000 1.000 27022241 D Milk, water babyfood/ infant form 0.500000 1.000 1.000 27032251 D Milk, sugar ( lactose) baby food/ 0.500000 1.000 1.000 05022290 5B Mustard greens 5.000000 1.000 1.000 12002300 12 Nectarine 0.200000 1.000 1.000 2 08002340 8 Okra 4.000000 1.000 1.000 22 03002370 3 Onion, dry bulb 1.000000 1.000 1.000 100% C Full comment: 100% CT 03002371 3 Onion, dry bulb babyfood 1.000000 1.000 1.000 100% C Full comment: 100% CT 03002380 3 Onion, dry bulb, dried 1.000000 9.000 1.000 100% C Full comment: 100% CT 03002381 3 Onion, dry bulb, dried babyfood 1.000000 9.000 1.000 100% C Full comment: 100% CT 03002390 3 Onion, green 1.000000 1.000 1.000 100% C Full comment: 100% CT 10002400 10 Orange 0.500000 1.000 1.000 7 10002410 10 Orange, juice 0.500000 1.000 1.000 7 10002411 10 Orange, juice babyfood 0.500000 1.000 1.000 7 10002420 10 Orange, peel 0.500000 1.000 1.000 7 04012480 4A Parsley, leaves 4.000000 1.000 1.000 06022550 6B Pea, succulent 0.400000 1.000 1.000 40 06022551 6B Pea, succulent babyfood 0.400000 1.000 1.000 40 06032560 6C Pea, dry 7.200000 1.000 1.000 06032561 6C Pea, dry babyfood 7.200000 1.000 1.000 06012570 6A Pea, edible podded, succulent 0.400000 1.000 1.000 40 06032580 6C Pea, pigeon, seed 7.200000 1.000 1.000 06022590 6B Pea, pigeon, succulent 0.400000 1.000 1.000 40 12002600 12 Peach 0.200000 1.000 1.000 9 12002601 12 Peach babyfood 0.200000 1.000 1.000 9 12002610 12 Peach, dried 0.200000 7.000 1.000 9 12002611 12 Peach, dried babyfood 0.200000 1.000 1.000 9 12002620 12 Peach, juice 0.200000 1.000 1.000 9 12002621 12 Peach, juice babyfood 0.200000 1.000 1.000 9 95002630 O Peanut 25.000000 1.000 1.000 34 95002640 O Peanut, butter 4.000000 1.890 1.000 95002650 O Peanut, oil 4.000000 1.000 1.000 11002660 11 Pear 0.200000 1.000 1.000 39 11002661 11 Pear babyfood 0.200000 1.000 1.000 39 11002670 11 Pear, dried 0.200000 6.250 1.000 39 11002680 11 Pear, juice 0.200000 1.000 1.000 39 11002681 11 Pear, juice babyfood 0.200000 1.000 1.000 39 14002690 14 Pecan 0.200000 1.000 1.000 100% C Full comment: 100% CT 08002700 8 Pepper, bell 4.000000 1.000 1.000 18 08002701 8 Pepper, bell babyfood 4.000000 1.000 1.000 18 08002710 8 Pepper, bell, dried 4.000000 1.000 1.000 18 08002711 8 Pepper, bell, dried babyfood 4.000000 1.000 1.000 18 08002720 8 Pepper, nonbell 4.000000 1.000 1.000 19 08002721 8 Pepper, nonbell babyfood 4.000000 1.000 1.000 19 08002730 8 Pepper, nonbell, dried 4.000000 1.000 1.000 19 95002750 O Peppermint 30.000000 1.000 1.000 95002760 O Peppermint, oil 30.000000 1.000 1.000 14002820 14 Pistachio 0.200000 1.000 1.000 100% C Full comment: 100% CT 25002900 M Pork, meat 0.200000 1.000 1.000 25002901 M Pork, meat babyfood 0.200000 1.000 1.000 25002910 M Pork, skin 1.000000 1.000 1.000 25002920 M Pork, meat byproducts 1.000000 1.000 1.000 25002921 M Pork, meat byproducts babyfood 1.000000 1.000 1.000 25002930 M Pork, fat 0.200000 1.000 1.000 25002931 M Pork, fat babyfood 0.200000 1.000 1.000 25002940 M Pork, kidney 1.000000 1.000 1.000 25002950 M Pork, liver 1.000000 1.000 1.000 01032960 1C Potato, chips 4.000000 0.900 1.000 8 01032970 1C Potato, dry ( granules/ flakes) 8.000000 2.000 1.000 8 01032971 1C Potato, dry ( granules/ flakes) b 8.000000 2.000 1.000 8 01032980 1C Potato, flour 4.000000 2.000 1.000 8 01032981 1C Potato, flour babyfood 4.000000 2.000 1.000 8 01032990 1C Potato, tuber, w/ peel 4.000000 1.000 1.000 8 01032991 1C Potato, tuber, w/ peel babyfood 4.000000 1.000 1.000 8 01033000 1C Potato, tuber, w/ o peel 4.000000 0.400 1.000 8 01033001 1C Potato, tuber, w/ o peel babyfood 4.000000 0.400 1.000 8 60003010 P Poultry, other, meat 0.200000 1.000 1.000 60003020 P Poultry, other, liver 2.000000 1.000 1.000 60003030 P Poultry, other, meat byproducts 2.000000 1.000 1.000 60003040 P Poultry, other, fat 0.200000 1.000 1.000 60003050 P Poultry, other, skin 2.000000 1.000 1.000 10003070 10 Pummelo 0.500000 1.000 1.000 100% C Full comment: 100% CT 09023080 9B Pumpkin 4.000000 1.000 1.000 25 09023090 9B Pumpkin, seed 0.440000 1.000 1.000 11003100 11 Quince 0.200000 1.000 1.000 39 100% C Full comment: 100% CT 29003120 M Rabbit, meat 0.200000 1.000 1.000 04013130 4A Radicchio 4.000000 1.000 1.000 05023180 5B Rape greens 5.000000 1.000 1.000 20003190 20 Rapeseed, oil 35.000000 1.000 0.080 20003191 20 Rapeseed, oil babyfood 35.000000 1.000 0.080 13013200 13A Raspberry 5.000000 1.000 1.000 100% C Full comment: 100% CT 13013201 13A Raspberry babyfood 5.000000 1.000 1.000 100% C Full comment: 100% CT 13013210 13A Raspberry, juice 5.000000 1.000 1.000 100% C Full comment: 100% CT 13013211 13A Raspberry, juice babyfood 5.000000 1.000 1.000 100% C Full comment: 100% CT 04023220 4B Rhubarb 4.000000 1.000 1.000 35 20003300 20 Safflower, oil 15.000000 1.000 1.000 20003301 20 Safflower, oil babyfood 15.000000 1.000 1.000 03003380 3 Shallot 1.000000 1.000 1.000 100% C Full comment: 100% CT 26003390 M Sheep, meat 0.200000 1.000 1.000 26003391 M Sheep, meat babyfood 0.200000 1.000 1.000 26003400 M Sheep, meat byproducts 1.000000 1.000 1.000 26003410 M Sheep, fat 0.200000 1.000 1.000 26003411 M Sheep, fat babyfood 0.200000 1.000 1.000 26003420 M Sheep, kidney 1.000000 1.000 1.000 26003430 M Sheep, liver 1.000000 1.000 1.000 06003470 6 Soybean, seed 1.440000 1.000 1.000 06003480 6 Soybean, flour 1.440000 1.000 1.000 06003481 6 Soybean, flour babyfood 1.440000 1.000 1.000 06003490 6 Soybean, soy milk 1.440000 1.000 1.000 06003491 6 Soybean, soy milk babyfood or in 1.440000 1.000 1.000 06003500 6 Soybean, oil 1.440000 1.000 1.000 06003501 6 Soybean, oil babyfood 1.440000 1.000 1.000 95003520 O Spearmint 30.000000 1.000 1.000 95003530 O Spearmint, oil 30.000000 1.000 1.000 04013550 4A Spinach 4.000000 1.000 1.000 15 04013551 4A Spinach babyfood 4.000000 1.000 1.000 15 09023560 9B Squash, summer 4.000000 1.000 1.000 25 09023561 9B Squash, summer babyfood 4.000000 1.000 1.000 25 09023570 9B Squash, winter 4.000000 1.000 1.000 25 09023571 9B Squash, winter babyfood 4.000000 1.000 1.000 25 95003590 O Strawberry 10.000000 1.000 1.000 10 95003591 O Strawberry babyfood 10.000000 1.000 1.000 10 95003600 O Strawberry, juice 10.000000 1.000 1.000 10 95003601 O Strawberry, juice babyfood 10.000000 1.000 1.000 10 20003640 20 Sunflower, seed 1.470000 1.000 1.000 20003650 20 Sunflower, oil 1.470000 1.000 1.000 20003651 20 Sunflower, oil babyfood 1.470000 1.000 1.000 01033660 1CD Sweet potato 4.000000 1.000 1.000 16 01033661 1CD Sweet potato babyfood 4.000000 1.000 1.000 16 04023670 4B Swiss chard 4.000000 1.000 1.000 10003690 10 Tangerine 0.500000 1.000 1.000 100% C Full comment: 100% CT 10003700 10 Tangerine, juice 0.500000 1.300 1.000 100% C Full comment: 100% CT 01033710 1CD Tanier, corm 4.000000 1.000 1.000 08003740 8 Tomatillo 4.000000 1.000 1.000 100% C Full comment: 100% CT 08003750 8 Tomato 4.000000 1.000 1.000 17 08003751 8 Tomato babyfood 4.000000 1.000 1.000 17 08003760 8 Tomato, paste 4.000000 2.000 1.000 17 08003761 8 Tomato, paste babyfood 4.000000 2.000 1.000 17 08003770 8 Tomato, puree 4.000000 1.200 1.000 17 08003771 8 Tomato, puree babyfood 4.000000 1.200 1.000 17 08003780 8 Tomato, dried 12.000000 14.300 1.000 17 08003781 8 Tomato, dried babyfood 12.000000 14.300 1.000 17 08003790 8 Tomato, juice 4.000000 0.800 1.000 17 95003800 O Tomato, Tree 4.000000 1.000 1.000 36 50003820 P Turkey, meat 0.200000 1.000 1.000 50003821 P Turkey, meat babyfood 0.200000 1.000 1.000 50003830 P Turkey, liver 2.000000 1.000 1.000 50003831 P Turkey, liver babyfood 2.000000 1.000 1.000 50003840 P Turkey, meat byproducts 2.000000 1.000 1.000 50003841 P Turkey, meat byproducts babyfood 2.000000 1.000 1.000 50003850 P Turkey, fat 0.200000 1.000 1.000 50003851 P Turkey, fat babyfood 0.200000 1.000 1.000 50003860 P Turkey, skin 2.000000 1.000 1.000 50003861 P Turkey, skin babyfood 2.000000 1.000 1.000 01033870 1CD Turmeric 4.000000 1.000 1.000 05023890 5B Turnip, greens 5.000000 1.000 1.000 37 14003910 14 Walnut 0.200000 1.000 1.000 100% C Full comment: 100% CT 09013990 9A Watermelon 4.000000 1.000 1.000 26 09014000 9A Watermelon, juice 4.000000 1.000 1.000 26 01034060 1CD Yam, true 4.000000 1.000 1.000 38 01034070 1CD Yam bean 4.000000 1.000 1.000 38 Attachment 5.

Applesfieldtrial 0.1 ppm, 1% TOTALNZ= 14 TOTALZ= 1386 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.12 0.15 0.1 0.1 0.1 0.1 Asparagus 4.0 ppm, 8% TOTALNZ= 8 TOTALZ= 92 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 Broccoli 5, 03 TOTALNZ= 3 TOTALZ= 97 5.0 5.0 5.0 Cabbage 5, 8% TOTALNZ= 8 TOTALZ= 92 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Cantaloupe 4.0, 13% TOTALNZ= 13 TOTALZ= 87 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 Carrots 1 ppm, 5% TOTALNZ= 5 TOTALZ= 95 1.0 1.0 1.0 1.0 1.0 Cauliflower 5, 5% TOTALNZ= 5 TOTALZ= 95 5.0 5.0 5.0 5.0 5.0 Cherry 0.2 ppm, 2% TOTALNZ= 2 TOTALZ= 98 0.2 Chili peppers 4.0 ppm, 20% TOTALNZ= 1 TOTALZ= 4 4.0 Cranberry 2.0 ppm, 12% TOTALNZ= 12 TOTALZ= 88 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Setheggplant 4.0, 10% TOTALNZ= 1 TOTALZ= 9 4.0 Gardenbeets 1 ppm, 10% TOTALNZ= 10 TOTALZ= 90 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Gardenbeettops 3 ppm, 10% TOTALNZ= 10 TOTALZ= 90 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Globeartichoke 5 ppm, 15% TOTALNZ= 15 TOTALZ= 85 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 GRAPESFT 0.1 ppm, 4% TOTALNZ= 6 TOTALZ= 144 0.1 0.1 0.1 0.32 0.11 0.56 Jerusalemartichoke 4 ppm, 15% TOTALNZ= 15 TOTALZ= 85 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Lemons 0.5 ppm, 10% TOTALNZ= 10 TOTALZ= 90 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Cucumber 4.0, 15% TOTALNZ= 15 TOTALZ= 85 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 Lettuce 4.0 ppm, 3% TOTALNZ= 3 TOTALZ= 97 4.0 4.0 4.0 Grapefruits 0.5 ppm, 4% TOTALNZ= 4 TOTALZ= 96 0.5 0.5 0.5 0.5 Okra 4.0,15% TOTALNZ= 15 TOTALZ= 85 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 Spinach 4.0 ppm, 1% TOTALNZ= 1 TOTALZ= 99 4.0 OrangesFT 0.5 ppm, 6% TOTALNZ= 6 TOTALZ= 94 0.13 0.1 0.1 0.1 0.1 0.1 Peanut 25 ppm, 16% TOTALNZ= 4 TOTALZ= 21 25.0 25.0 25.0 25.0 PearsFT 0.1 ppm, 1% CT TOTALNZ= 8 TOTALZ= 792 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Potatoes 19 results ppm, 6% TOTALNZ= 9 TOTALZ= 141 1.00 0.93 1.84 2.95 1.41 1.03 1.33 0.25 0.52 Pumpkinsquash 4, 11% TOTALNZ= 11 TOTALZ= 89 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 Rhubarb 4 ppm, 15% TOTALNZ= 15 TOTALZ= 85 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 STONEFRUIT 0.2 ppm, 1% TOTALNZ= 1 TOTALZ= 99 0.2 Sweet Potatoes 4.0, 24 TOTALNZ= 12 TOTALZ= 38 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 Tomato 4.0, 6% TOTALNZ= 6 TOTALZ= 94 4.0 4.0 4.0 4.0 4.0 4.0 Tomatotree 4 ppm, 6% TOTALNZ= 6 TOTALZ= 94 4.0 4.0 4.0 4.0 4.0 4.0 Peppers 4.0, 7% CT TOTALNZ= 7 TOTALZ= 93 4.0 4.0 4.0 4.0 4.0 4.0 4.0 Turnipgreens 5 ppm, 10% TOTALNZ= 10 TOTALZ= 90 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Watermelon 4, 20% TOTALNZ= 1 TOTALZ= 4 4.0 Greenpeas 7, 4% CT TOTALNZ= 7 TOTALZ= 168 3.9 4.2 6.0 4.7 1.4 4.1 7.0 Yams 4 ppm, 10% TOTALNZ= 10 TOTALZ= 90 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 StrawberriesFT 11 values, 10% TOTALNZ= 11 TOTALZ= 99 2.4 6.1 7.1 7.1 7.9 4.2 4.3 8.3 5.5 9.4 5.5 Peaches 11, 1% TOTALNZ= 1 TOTALZ= 99 0.1 GREANBEANS 6, 10% ct TOTALNZ= 6 TOTALZ= 54 3.9 7.5 3.6 4.8 5.7 0.52 GREANBEANS LIMA 6, 12% ct TOTALNZ= 6 TOTALZ= 44 3.9 7.5 3.6 4.8 5.7 0.52


 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

Office of

Prevention, Pesticides and

Toxic Substances

                 Office of Prevention, Pesticides

DATE:  July 11, 2007

MEMORANDUM

Subject:  Transmission of Background Materials for the August 14-15,
2007 FIFRA Scientific Advisory Panel Entitled “Review of
EPA/ORD/NERL’s SHEDS-Multimedia Model, Aggregate Version 3”

To:  		Melissa Kramer, Designated Federal Official

FIFRA SAP

Office of Science Coordination and Policy

From:  	Dana Vogel

Office of Pesticide Programs

Health Effects Division (7509PY)

Through:	Tina Levine, Ph.D., Director

Office of Pesticide Programs

Health Effects Division (7509PY)

Attached please find the first set of background materials (1 of 2) and
related charge questions for the August 14-15, 2007 FIFRA Scientific
Advisory Panel entitled “Review of EPA/ORD/NERL’s SHEDS-Multimedia
Model, Aggregate Version 3.”    SEQ CHAPTER \h \r 1 The purpose of
this 2-day meeting is to request:

(1) a formal model review by the SAP on the Stochastic Human Exposure
and Dose Simulation for Multimedia, Multipathway Pollutants
(SHEDS-Multimedia), aggregate version 3 (residential module);

(2) a peer consultation by the SAP on planned methodologies to extend
SHEDS-Multimedia version 3 to version 4; and

(3) a peer consultation by the SAP on the SHEDS-Multimedia dietary
module that will also be incorporated into SHEDS-Multimedia version 4.

This SAP review is part of the Agency’s ongoing process to enhance
probabilistic risk assessments and OPP’s ongoing efforts to address
safety standards of the Food Quality Protection Act (FQPA) of 1996.
FQPA amended the laws under which EPA evaluates the safety of pesticide
residues in food.  Section 408(b)(2)(D)(v) and (vi) of the Federal Food
Drug and Cosmetic Act, as amended by FQPA, specifies that when
determining the safety of a pesticide chemical, EPA shall consider
aggregate exposure (i.e., total dietary (food and water), residential,
and other non-occupational) and available information concerning the
cumulative effects to human health that may result from exposure to
other substances that have a common mechanism of toxicity.

SHEDS-Multimedia can address many useful aspects of aggregate and
cumulative risk assessment related to population aggregate exposures for
different multimedia chemicals and the important contributing pathways
and factors.  Such information will be useful in identifying populations
and exposure scenarios of greatest concern for this class of chemicals.
These populations and exposure scenarios will in turn be used to
determine the most relevant chemical/pyrethroid combinations for which
hazard/exposure factors information will need further development in
order to support a PBPK dose modeling approach.  EPA plans to extend the
current single chemical aggregate version (version 3) of SHEDS to
version 4, a cumulative (multi-chemical) version that will include both
the residential and dietary modules, i.e., estimate both residential and
dietary exposures for simulated individuals.  The cumulative version of
SHEDS, which will also include enhancements to version 3 to be reviewed
by the August 14-14, 2007 SAP, will be used to estimate cumulative
exposure to pyrethroid pesticides. Agency staff from ORD/ NERL are
collaborating with the Office of Pesticide Programs (OPP) on development
and application of the various modules for the SHEDS-Multimedia version
4 model.

  SEQ CHAPTER \h \r 1 To assist the August 14-15, 2007 FIFRA SAP in
their review of the SHEDS-Multimedia version 3 (aggregate residential)
model, each FIFRA SAP member will be provided CD(s) containing a
technical report describing the SHEDS-Multimedia version 3 model,
annotated SHEDS code with a graphical user interface, and a user guide
for the graphical user interface.  Below are the related charge
questions for this portion of the SAP meeting.    Three issues will be
presented for the FIFRA SAP review of the SHEDS-Multimedia version 3.
The materials and related charge questions for Issue 1 are detailed
below.  Separate materials and charge questions will be provided
subsequently to the SAP for Issue 2 (version 4 planned methodologies)
and Issue 3 (SHEDS-dietary module).

I.  Charge Questions Related to the Review of EPA/ORD/NERL’s
SHEDS-Multimedia Model, Aggregate Version 3

Issue 1:  Documentation, completeness, and clarity of the technical
aspects and usability of the SHEDS-Multimedia version 3 (aggregate
residential) model

Question 1:  The SHEDS-Multimedia version 3 User’s Manual provided to
the SAP presents installation and operational instructions for the
software.

a)  Were Panel members able to load the software on to their computers?
What, if any, difficulties were encountered in loading or running the
software?

b)	The SHEDS-Multimedia version 3 graphical user interface (GUI) was
designed to be user-friendly to exposure modelers and risk assessors.
Please comment on the organization and usability of the GUI, any
difficulties you encountered, which features and output capabilities
were most useful, and whether any additional options would be helpful.
Please also comment or offer suggestions for improving the GUI/model
interface.

 c) 	Please comment on the organization, clarity, completeness, and
usefulness of the User Guide document and provide any suggestions for
improvement.

Question 2:  The SHEDS-Multimedia version 3 Technical Manual provided to
the SAP provides an overview of the SHEDS-Multimedia aggregate
residential model; presents  detailed descriptions of key model
components; and describes the model construct and algorithms, required
inputs, and analysis/output capabilities.

a)	Please comment on whether the descriptions of specific model
components are scientifically sound and whether the algorithms described
in the Technical Manual represent the state of the science for
performing exposure assessments.   Please also comment or offer
suggestions for improving or modifying these algorithms or other aspects
of the model construct.

b)	Please comment on the organization, clarity, completeness and
usefulness of the Technical Manual and provide any suggestions for
improvement.

Question 3: The Source Code Directory on the CD provided to the SAP
includes annotated code for the exposure algorithms used in the
SHEDS-Multimedia aggregate residential model.

Please comment on whether the annotated code is sufficiently clear such
that the algorithms can be followed and understood.

Please also comment on whether these algorithms are technically correct
and consistent with the descriptions provided in the technical manual.

II. List of Attachments for SHEDS-Multimedia version 3 Residential
Module Review:

Installation Instructions for the SHEDS-Multimedia version 3 (aggregate
residential) model (filename:  SHEDS_Multimedia_Installation.doc)

SHEDS-Multimedia version 3 (aggregate residential) model (installation
for code review and running/testing model with graphic user interface)(
filename:  SHEDS_Multimedia_Setup_3.14c.exe)

SHEDS-Multimedia version 3 (aggregate residential) model Users Guide
(filename:  SHEDS-Multimedia3_UsersGuide_06_13.pdf)

SHEDS-Multimedia version 3 Technical Manual (filename:
SHEDS_TechManual_06-14.pdf)


[Federal Register Volume 84, Number 172 (Thursday, September 5, 2019)]
[Notices]
[Page 46774]
[FR Doc No: 2019-19137]

-----------------------------------------------------------------------

DEPARTMENT OF TRANSPORTATION

Federal Aviation Administration

[Summary Notice No. FAA-2019-53]

Petition for Exemption; Summary of Petition Received; Wing
Aviation, LLC

AGENCY: Federal Aviation Administration (FAA), Department of
Transportation (DOT).

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: This notice contains a summary of a petition seeking relief
from specified requirements of Federal Aviation Regulations. The
purpose of this notice is to improve the public's awareness of, and
participation in, the FAA's exemption process. Neither publication of
this notice nor the inclusion or omission of information in the summary
is intended to affect the legal status of the petition or its final
disposition.

DATES: Comments on this petition must identify the petition docket
number and must be received on or before September 20, 2019.

ADDRESSES: Send comments identified by docket number FAA-2018-0835
using any of the following methods:
     Federal eRulemaking Portal: Go to http://www.regulations.gov and follow the online instructions for sending your
comments electronically.
     Mail: Send comments to Docket Operations, M-30; U.S.
Department of Transportation, 1200 New Jersey Avenue SE, Room W12-140,
West Building Ground Floor, Washington, DC 20590-0001.
     Hand Delivery or Courier: Take comments to Docket
Operations in Room W12-140 of the West Building Ground Floor at 1200
New Jersey Avenue SE, Washington, DC 20590-0001, between 9 a.m. and 5
p.m., Monday through Friday, except Federal holidays.
     Fax: Fax comments to Docket Operations at<PHONE_NUMBER>.
    Privacy: In accordance with 5 U.S.C. 553(c), DOT solicits comments
from the public to better inform its rulemaking process. DOT posts
these comments, without edit, including any personal information the
commenter provides, to http://www.regulations.gov, as described in the
system of records notice (DOT/ALL-14 FDMS), which can be reviewed at
http://www.dot.gov/privacy.
    Docket: Background documents or comments received may be read at
http://www.regulations.gov at any time. Follow the online instructions
for accessing the docket or go to the Docket Operations in Room W12-140
of the West Building Ground Floor at 1200 New Jersey Avenue SE,
Washington, DC 20590-0001, between 9 a.m. and 5 p.m., Monday through
Friday, except Federal holidays.

FOR FURTHER INFORMATION CONTACT: Nia Daniels,<PHONE_NUMBER>, Office of
Rulemaking, Federal Aviation Administration, 800 Independence Avenue
SW, Washington, DC 20591.
    This notice is published pursuant to 14 CFR 11.85.

    Issued in Washington, DC, on August 21, 2019.
John Linsenmeyer,
Acting Deputy Director, Office of Rulemaking.

Petition for Exemption

    Docket No.: FAA-2018-0835.
    Petitioner: Wing Aviation, LLC.
    Sections of 14 CFR Affected: Sec. Sec.  135.321; 135.323; 135.325;
135.327; 135.329; 135.330; 135.331; 135.335; 135.337; 135.338; 135.339;
135.340; 135.341; 135.343; 135.345; 135.347; 135.351; 135.433; and
135.501(a).
    Description of Relief Sought: Wing Aviation, LLC seeks an amendment
to its existing exemption to allow it to conduct part 135 air carrier
operations using small unmanned aircraft systems (UAS). This amendment
would enable Wing to train its personnel- pilots in command, visual
observers, and nest managers.

[FR Doc. 2019-19137 Filed 9-4-19; 8:45 am]
 BILLING CODE 4910-13-P