166.324	82608.7736

	0.150

CM-01

	CO2 Trap 1

	144 h

	0.00

	495.81

	495.81

	1.0236

1.0339 	159.56

151.52	40.80

40.80	118.760

110.720

	116.022

107.090	55310.4673

	0.100

CM-01

	CO2 Trap 1

	168 h

	0.00

	432.25

	432.25

	1.0576

1.0552 	146.06

133.70	48.32

48.32	97.737

85.377

	*

*	92.414

80.910	37459.6609

	0.068

CM-02

	CO2 Trap 1

	  1 h

	0.00

	523.60

	523.60

	1.0640

1.0310 	508.20

488.51	18.43

18.43	489.773

470.083

	460.313

455.949<PHONE_NUMBER>

	0.416

CM-02

	CO2 Trap 1

	  3 h

	0.00

	504.82

	504.82

	1.0022

1.0333 	1348.34

1431.13	18.43

18.43	1329.913

1412.703

	1326.994

1367.176<PHONE_NUMBER>

	1.181

CM-02

	CO2 Trap 1

	  6 h

	0.00

	503.45

	503.45

	1.1323

1.0111 	4729.43

4098.53	15.38

15.38	4714.049

4083.149

	4163.251

4038.324	2064541.3872

	3.584

CM-02

	CO2 Trap 1

	 24 h

	0.00

	520.27

	520.27

	1.0500

1.0381 	12921.11

13081.04	15.38

15.38	12905.729

13065.659

	12291.171

12586.128	6471455.9649

	11.235

CM-02

	CO2 Trap 1

	 48 h

	0.00

	503.79

	503.79

	1.2546

1.0504 	870.87

775.99	15.38

15.38	855.489

760.609

	681.882

724.114<PHONE_NUMBER>

	0.615

CM-02

	CO2 Trap 1

	 72 h

	0.00

	540.28

	540.28

	1.0407

1.0324 	292.56

275.18	15.38

15.38	277.179

259.799

	266.339

251.646<PHONE_NUMBER>

	0.243

CM-02

	CO2 Trap 1

	 96 h

	0.00

	503.82

	503.82

	1.0489

1.0422 	195.67

188.68	15.38

15.38	180.289

173.299

	171.884

166.282	85187.3860

	0.148

CM-02

	CO2 Trap 1

	120 h

	0.00

	383.39

	383.39

	1.0480

1.0314 	188.00

169.96	15.38

15.38	172.619

154.579

	164.713

149.873	60304.5536

	0.105

CM-02

	CO2 Trap 1

	144 h

	0.00

	481.47

	481.47

	1.0445

1.0342 	161.63

170.29	40.80

40.80	120.830

129.490

	115.682

125.208	57990.6625

	0.101

CM-02

	CO2 Trap 1

	168 h

	0.00

	441.91

	441.91

	1.0512

1.0547 	137.23

140.04	48.32

48.32	88.907

91.717

	*

*	84.576

86.960	37901.8063

	0.066

Table 6 (contd).  Recovery of Radioactivity in CO2 Trap 1 from Group C.

Subject	Sample	Time	Pot wt	Samp wt	Corr Samp	Alq wt	Orig DPM	Bkg DPM Calc DPM	LOD	LOQ	DPM/g	Sample DPM	Reco (%)

CM-03

	CO2 Trap 1

	  1 h

	0.00

	526.18

	526.18

	1.0554

1.0172 	491.89

475.81	18.43

18.43	473.463

457.383

	448.610

449.649<PHONE_NUMBER>

	0.381

CM-03

	CO2 Trap 1

	  3 h

	0.00

	468.45

	468.45

	1.0701

1.0076 	1592.14

1404.32	18.43

18.43	1573.713

1385.893

	1470.623

1375.440<PHONE_NUMBER>

	1.076

CM-03

	CO2 Trap 1

	  6 h

	0.00

	491.87

	491.87

	1.3109

1.3951 	5863.37

6424.76	15.38

15.38	5847.989

6409.379

	4461.049

4594.208	2227004.5358

	3.593

CM-03

	CO2 Trap 1

	 24 h

	0.00

	480.16

	480.16

	1.0451

1.0455 	15663.79

17512.06	15.38

15.38	15648.409

17496.679

	14973.121

16735.226	7612540.0951

	12.283

CM-03

	CO2 Trap 1

	 48 h

	0.00

	537.25

	537.25

	1.1550

0.9654 	1619.51

1332.57	15.38

15.38	1604.129

1317.189

	1388.856

1364.397<PHONE_NUMBER>

	1.193

CM-03

	CO2 Trap 1

	 72 h

	0.00

	475.62

	475.62

	1.0470

1.0434 	572.84

546.39	15.38

15.38	557.459

531.009

	532.435

508.922<PHONE_NUMBER>

	0.400

CM-03

	CO2 Trap 1

	 96 h

	0.00

	499.88

	499.88

	1.0463

1.0202 	296.67

262.08	15.38

15.38	281.289

246.699

	268.842

241.814<PHONE_NUMBER>

	0.206

CM-03

	CO2 Trap 1

	120 h

	0.00

	497.56

	497.56

	1.0396

1.0529 	249.39

256.31	15.38

15.38	234.009

240.929

	225.095

228.824<PHONE_NUMBER>

	0.182

CM-03

	CO2 Trap 1

	144 h

	0.00

	457.74

	457.74

	1.0297

1.0297 	242.00

246.60	40.80

40.80	201.200

205.800

	195.397

199.864	90463.3291

	0.146

CM-03

	CO2 Trap 1

	168 h

	0.00

	426.92

	426.92

	1.0598

1.0556 	183.58

171.41	48.32

48.32	135.257

123.087

	127.625

116.604	52132.9559

	0.084

CM-04

	CO2 Trap 1

	  1 h

	0.00

	522.07

	522.07

	1.0378

1.0418 	508.33

504.27	18.43

18.43	489.903

485.843

	472.059

466.350<PHONE_NUMBER>

	1.600

CM-04

	CO2 Trap 1

	  3 h

	0.06

	479.56

	479.50

	1.1495

1.2601 	1653.86

2024.88	18.43

18.43	1635.433

2006.453

	1422.735

1592.297<PHONE_NUMBER>

	4.720

CM-04

	CO2 Trap 1

	  6 h

	0.00

	530.40

	530.40

	1.0388

1.0498 	3363.69

3498.30	15.38

15.38	3348.309

3482.919

	3223.247

3317.698	1734658.5733

	11.328

CM-04

	CO2 Trap 1

	 24 h

	0.00

	484.93

	484.93

	1.0492

1.0588 	12420.51

13959.27	15.38

15.38	12405.129

13943.889

	11823.417

13169.521	6059912.7649

	39.572

CM-04

	CO2 Trap 1

	 48 h

	0.00

	495.21

	495.21

	1.0911

1.0175 	944.90

762.90	15.38

15.38	929.519

747.519

	851.910

734.662<PHONE_NUMBER>

	2.565

CM-04

	CO2 Trap 1

	 72 h

	0.00

	492.82

	492.82

	1.0427

1.0333 	421.32

396.78	15.38

15.38	405.939

381.399

	389.315

369.108<PHONE_NUMBER>

	1.220

CM-04

	CO2 Trap 1

	 96 h

	0.00

	534.71

	534.71

	1.0459

1.0354 	240.52

242.19	15.38

15.38	225.139

226.809

	215.259

219.055<PHONE_NUMBER>

	0.758

CM-04

	CO2 Trap 1

	120 h

	0.00

	514.48

	514.48

	1.0429

1.0431 	189.01

177.93	15.38

15.38	173.629

162.549

	166.487

155.833	82913.4703

	0.541

CM-04

	CO2 Trap 1

	144 h

	0.00

	481.13

	481.13

	1.0371

1.0425 	170.62

180.41	40.80

40.80	129.820

139.610

	125.176

133.918	62329.0532

	0.407

CM-04

	CO2 Trap 1

	168 h

	0.00

	447.61

	447.61

	1.0445

1.0402 	150.64

134.50	48.32

48.32	102.317

86.177

	*

*	97.958

82.846	40464.7951

	0.264

* in LOD column indicates that sample DPM were less than background DPM, and in LOQ column indicates that sample DPM was less than 3 x background.

Table 7.  Recovery of Radioactivity in CO2 Trap 2 from Group C.

Subject	Sample	Time	Pot wt	Samp wt	Corr Samp	Alq wt	Orig DPM	Bkg DPM Calc DPM	LOD	LOQ	DPM/g	Sample DPM	Reco (%)

CM-01

	CO2 Trap 2

	  1 h

	0.00

	467.41

	467.41

	1.0360

1.0249 	19.37

18.92	18.43

18.43	0.943

0.493

	*

*	0.911

0.481	325.2943

	0.001

CM-01

	CO2 Trap 2

	  3 h

	0.00

	494.91

	494.91

	1.0448

1.0472 	1523.93

1487.19	29.40

29.40	1494.535

1457.795

	1430.451

1392.088<PHONE_NUMBER>

	1.265

CM-01

	CO2 Trap 2

	  6 h

	0.00

	500.60

	500.60

	0.8320

1.0826 	24.58

35.51	15.38

15.38	9.199

20.129

	*

*	11.057

18.593	7421.3663

	0.013

CM-01

	CO2 Trap 2

	 24 h

	0.00

	480.62

	480.62

	1.0296

1.0314 	1111.84

1102.61	15.38

15.38	1096.459

1087.229

	1064.937

1054.129<PHONE_NUMBER>

	0.922

CM-01

	CO2 Trap 2

	 48 h

	0.00

	485.06

	485.06

	1.0431

1.0131 	262.34

252.68	15.38

15.38	246.959

237.299

	236.755

234.231<PHONE_NUMBER>

	0.207

CM-01

	CO2 Trap 2

	 72 h

	0.00

	500.26

	500.26

	1.0470

1.0260 	137.03

144.06	15.38

15.38	121.649

128.679

	116.188

125.418	60433.0240

	0.109

CM-01

	CO2 Trap 2

	 96 h

	0.01

	550.29

	550.28

	1.0437

1.0423 	78.87

74.13	15.38

15.38	63.489

58.749

	60.831

56.365	32245.2092

	0.058

CM-01

	CO2 Trap 2

	120 h

	0.00

	529.51

	529.51

	1.0278

1.0170 	59.03

53.50	15.38

15.38	43.649

38.119

	42.468

37.482	21167.2592

	0.038

CM-01

	CO2 Trap 2

	144 h

	0.00

	496.85

	496.85

	1.0352

1.0031 	94.44

85.95	40.80

48.32	53.640

37.627

	*

*	51.816

37.510	22190.9255

	0.040

CM-01

	CO2 Trap 2

	168 h

	0.00

	423.49

	423.49

	1.0497

1.0511 	95.33

92.32	48.32

48.32	47.007

43.997

	*

*	44.781

41.858	18345.3295

	0.033

CM-02

	CO2 Trap 2

	  1 h

	0.00

	571.59

	571.59

	1.0299

1.0281 	22.36

18.92	18.43

18.43	3.933

0.493

	*

*	3.819

0.480	1228.6300

	0.002

CM-02

	CO2 Trap 2

	  3 h

	0.00

	507.47

	507.47

	1.1457

1.0445 	32.47

32.25	18.43

18.43	14.043

13.823

	*

*	12.257

13.234	6468.1692

	0.011

CM-02

	CO2 Trap 2

	  6 h

	0.01

	548.70

	548.69

	1.0659

1.0745 	40.36

38.96	15.38

15.38	24.979

23.579

	*

*	23.435

21.944	12449.4979

	0.022

CM-02

	CO2 Trap 2

	 24 h

	0.00

	480.57

	480.57

	1.0380

1.0382 	710.86

719.07	15.38

15.38	695.479

703.689

	670.018

677.797<PHONE_NUMBER>

	0.562

CM-02

	CO2 Trap 2

	 48 h

	0.00

	596.52

	596.52

	0.9346

1.0249 	217.10

245.07	15.38

15.38	201.719

229.689

	215.835

224.109<PHONE_NUMBER>

	0.228

CM-02

	CO2 Trap 2

	 72 h

	0.00

	526.52

	526.52

	1.0378

1.0208 	175.16

163.67	15.38

15.38	159.779

148.289

	153.959

145.268	78774.4871

	0.137

CM-02

	CO2 Trap 2

	 96 h

	0.00

	519.50

	519.50

	1.0404

1.0380 	107.02

101.02	15.38

15.38	91.639

85.639

	88.081

82.504	44309.3432

	0.077

CM-02

	CO2 Trap 2

	120 h

	0.00

	539.26

	539.26

	1.0359

1.0388 	90.59

89.39	15.38

15.38	75.209

74.009

	72.603

71.245	38785.5875

	0.067

CM-02

	CO2 Trap 2

	144 h

	0.05

	466.00

	465.95

	1.0233

1.0246 	86.46

89.29	40.80

40.80	45.660

48.490

	*

*	44.620

47.326	21421.1500

	0.037

CM-02

	CO2 Trap 2

	168 h

	0.00

	446.26

	446.26

	1.0401

1.0393 	93.68

80.83	48.32

48.32	45.357

32.507

	*

*	43.608

31.277	16709.1902

	0.029

Table 7 (contd).  Recovery of Radioactivity in CO2 Trap 2 from Group C.

Subject	Sample	Time	Pot wt	Samp wt	Corr Samp	Alq wt	Orig DPM	Bkg DPM Calc DPM	LOD	LOQ	DPM/g	Sample DPM	Reco (%)

CM-03

	CO2 Trap 2

	  1 h

	0.00

	521.17

	521.17

	1.0485

1.0273 	18.69

22.82	18.43

18.43	0.263

4.393

	*

*	0.251

4.277	1179.8598

	0.002

CM-03

	CO2 Trap 2

	  3 h

	0.00

	493.38

	493.38

	1.1244

1.0920 	31.80

29.95	18.43

18.43	13.373

11.523

	*

*	11.894

10.553	5537.2663

	0.009

CM-03

	CO2 Trap 2

	  6 h

	0.00

	490.60

	490.60

	1.0724

1.1990 	52.79

56.31	15.38

15.38	37.409

40.929

	34.884

34.136	16930.4947

	0.027

CM-03

	CO2 Trap 2

	 24 h

	0.00

	483.12

	483.12

	1.0375

1.0375 	1691.43

1674.66	15.38

15.38	1676.049

1659.279

	1615.469

1599.305<PHONE_NUMBER>

	1.253

CM-03

	CO2 Trap 2

	 48 h

	0.00

	525.06

	525.06

	1.0157

1.0333 	500.41

537.45	15.38

15.38	485.029

522.069

	477.532

505.244<PHONE_NUMBER>

	0.416

CM-03

	CO2 Trap 2

	 72 h

	0.00

	533.66

	533.66

	1.0400

1.0266 	186.17

166.03	15.38

15.38	170.789

150.649

	164.220

146.746	82975.0407

	0.134

CM-03

	CO2 Trap 2

	 96 h

	0.00

	534.21

	534.21

	1.0271

1.0309 	96.23

99.43	15.38

15.38	80.849

84.049

	78.716

81.530	42802.4303

	0.069

CM-03

	CO2 Trap 2

	120 h

	0.00

	499.09

	499.09

	1.0322

1.0397 	60.01

65.28	15.38

15.38	44.629

49.899

	43.237

47.994	22766.1409

	0.037

CM-03

	CO2 Trap 2

	144 h

	0.00

	434.99

	434.99

	1.0310

1.0316 	100.62

109.29	40.80

40.80	59.820

68.490

	*

*	58.021

66.392	27059.2818

	0.044

CM-03

	CO2 Trap 2

	168 h

	0.00

	463.41

	463.41

	1.0418

1.0509 	97.90

98.78	48.32

48.32	49.577

50.457

	*

*	47.588

48.013	22151.0729

	0.036

CM-04

	CO2 Trap 2

	  1 h

	0.00

	506.47

	506.47

	1.0202

1.1229 	18.23

19.42	18.43

18.43	0.000

0.993	*

*

	0.000

0.885	224.0153

	0.001

CM-04

	CO2 Trap 2

	  3 h

	0.00

	470.22

	470.22

	1.0450

1.1401 	25.34

22.15	18.43

18.43	6.913

3.723

	*

*	6.616

3.266	2323.2219

	0.015

CM-04

	CO2 Trap 2

	  6 h

	0.00

	507.89

	507.89

	1.0146

1.0599 	41.43

36.22	15.38

15.38	26.049

20.839

	*

*	25.674

19.661	11512.7544

	0.075

CM-04

	CO2 Trap 2

	 24 h

	0.00

	498.50

	498.50

	1.0329

1.0390 	1334.77

1321.62	15.38

15.38	1319.389

1306.239

	1277.364

1257.208<PHONE_NUMBER>

	4.125

CM-04

	CO2 Trap 2

	 48 h

	0.00

	503.19

	503.19

	1.0357

1.0142 	306.46

313.37	15.38

15.38	291.079

297.989

	281.046

293.817<PHONE_NUMBER>

	0.944

CM-04

	CO2 Trap 2

	 72 h

	0.00

	497.60

	497.60

	1.0417

1.0332 	164.92

149.96	15.38

15.38	149.539

134.579

	143.553

130.255	68123.3236

	0.445

CM-04

	CO2 Trap 2

	 96 h

	0.00

	500.89

	500.89

	1.0382

1.0325 	84.11

92.55	15.38

15.38	68.729

77.169

	66.200

74.740	35297.7887

	0.231

CM-04

	CO2 Trap 2

	120 h

	0.00

	503.19

	503.19

	1.0374

1.0343 	57.23

75.47	15.38

15.38	41.849

60.089

	40.340

58.096	24766.1932

	0.162

CM-04

	CO2 Trap 2

	144 h

	0.00

	460.40

	460.40

	1.0349

1.0484 	85.61

78.99	40.80

40.80	44.810

38.190

	*

*	43.299

36.427	18352.8805

	0.120

CM-04

	CO2 Trap 2

	168 h

	0.00

	431.17

	431.17

	1.0396

1.0489 	85.88

84.29	48.32

48.32	37.557

35.967

	*

*	36.126

34.290	15180.6258

	0.099

* in LOD column indicates that sample DPM were less than background DPM, and in LOQ column indicates that sample DPM was less than 3 x background.

Table 8.  Recovery of Radioactivity in Exhaled VOC Trap 1 from Group C.

Subjecta	Sample	Time	Pot wt	Samp wt	Corr Samp	Alq wt	Orig DPM	Bkg DPM Calc DPM	LOD	LOQ	DPM/g	Sample DPM	Reco (%)

CM-01

	Exhaled VOC Trap 1  	  1 h

	17.5558

	25.3023

	7.7465

	0.0474

0.0483 	99943.74

100749.81	25.67

25.67	99918.074

100724.144

	2107976.239

2085385.999	16241940.2899

	29.410

CM-01

	Exhaled VOC Trap 1  	  3 h

	17.5676

	25.3483

	7.7807

	0.0460

0.0474 	59579.64

61273.30	25.67

25.67	59553.974

61247.634

	1294651.603

1292144.172	10063540.9441

	18.222

CM-01

	Exhaled VOC Trap 1  	  6 h

	17.5313

	25.3044

	7.7731

	0.0476

0.0482 	44284.21

44039.05	25.67

25.67	44258.544

44013.384

	929801.339

913140.742	7162686.5449

	12.970

CM-01

	Exhaled VOC Trap 1  	 24 h

	17.6593

	25.4422

	7.7829

	0.0469

0.0480 	13796.80

13896.70	25.67

25.67	13771.134

13871.034

	293627.585

288979.870	2267187.7811

	4.105

CM-01

	Exhaled VOC Trap 1  	 48 h

	17.6284

	21.4364

	3.8080

	0.0497

0.0485 	378.90

367.05	25.59

25.59	353.308

341.458

	7108.803

7040.361	26940.0076

	0.049

CM-01

	Exhaled VOC Trap 1  	 72 h

	17.6258

	21.4358

	3.8100

	0.0484

0.0494 	156.32

165.32	25.59

25.59	130.728

139.728

	2700.981

2828.492	10533.6467

	0.019

CM-01

	Exhaled VOC Trap 1  	 96 h

	17.6580

	21.5898

	3.9318

	0.0458

0.0480 	90.47

81.26	26.58

26.58	63.886

54.676

	1394.891

1139.083	4981.5398

	0.009

CM-01

	Exhaled VOC Trap 1  	120 h

	17.7819

	21.7156

	3.9337

	0.0477

0.0508 	70.95

67.63	26.58

26.58	44.366

41.046

	*

*	930.105

807.992	3418.5760

	0.006

CM-01

	Exhaled VOC Trap 1  	144 h

	17.4693

	21.3647

	3.8954

	0.0492

0.0482 	57.05

59.98	26.58

26.58	30.466

33.396

	*

*	619.228

692.863	2555.5591

	0.005

CM-01

	Exhaled VOC Trap 1  	168 h

	17.7322

	21.6433

	3.9111

	0.0459

0.0485 	51.39

50.39	25.67

25.67	25.717

24.717

	*

*	560.276

509.622	2092.2389

	0.004

CM-02

	Exhaled VOC Trap 1  	  1 h

	17.5459

	25.2954

	7.7495

	0.0482

0.0469 	121083.68

121609.67	25.67

25.67	121058.014

121584.004

	2511577.049

2592409.462	19776671.7311

	34.334

CM-02

	Exhaled VOC Trap 1  	  3 h

	17.5840

	25.3323

	7.7483

	0.0472

0.0491 	73991.88

76960.98	25.67

25.67	73966.214

76935.314

	1567080.800

1566910.667	12141553.0411

	21.079

CM-02

	Exhaled VOC Trap 1  	  6 h

	17.4309

	25.1783

	7.7474

	0.0474

0.0493 	45609.96

45949.57	25.67

25.67	45584.294

45923.904

	961693.961

931519.346	7333740.3866

	12.732

CM-02

	Exhaled VOC Trap 1  	 24 h

	17.5774

	25.3569

	7.7795

	0.0475

0.0472 	4309.84

4259.25	25.67

25.67	4284.174

4233.584

	90193.132

89694.571<PHONE_NUMBER>

	1.215

CM-02

	Exhaled VOC Trap 1  	 48 h

	17.5024

	21.3221

	3.8197

	0.0488

0.0492 	303.20

285.14	25.59

25.59	277.608

259.548

	5688.678

5275.356	20939.6603

	0.036

CM-02

	Exhaled VOC Trap 1  	 72 h

	17.7206

	21.5519

	3.8313

	0.0485

0.0478 	214.15

210.72	25.59

25.59	188.558

185.128

	3887.784

3872.960	14866.8688

	0.026

CM-02

	Exhaled VOC Trap 1  	 96 h

	17.6396

	21.5424

	3.9028

	0.0479

0.0464 	151.99

165.19	26.58

26.58	125.406

138.606

	2618.079

2987.198	10938.1387

	0.019

CM-02

	Exhaled VOC Trap 1  	120 h

	17.8302

	21.7374

	3.9072

	0.0472

0.0477 	99.39

98.53	26.58

26.58	72.806

71.946

	1542.500

1508.302	5960.0466

	0.010

CM-02

	Exhaled VOC Trap 1  	144 h

	17.6197

	21.5368

	3.9171

	0.0470

0.0471 	76.54

89.14	26.58

26.58	49.956

62.556

	*

*	1062.894

1328.153	4682.9841

	0.008

CM-02

	Exhaled VOC Trap 1  	168 h

	17.9646

	21.8586

	3.8940

	0.0490

0.0464 	68.06

66.63	25.67

25.67	42.387

40.957

	*

*	865.034

882.687	3402.8124

	0.006

a Samples from CM-04 were not analyzed.

* in LOD column indicates that sample DPM were less than background DPM, and in LOQ column indicates that sample DPM was less than 3 x background. Table 8 (contd).  Recovery of Radioactivity in Exhaled VOC Trap 1 from Group C.

Subject	Sample	Time	Pot wt	Samp wt	Corr Samp	Alq wt	Orig DPM	Bkg DPM Calc DPM	LOD	LOQ	DPM/g	Sample DPM	Reco (%)

CM-03

	Exhaled VOC Trap 1

	  1 h

	17.4816

	25.5681

	8.0865

	0.0471

0.0462 	103897.22

100125.02	25.67

25.67	103871.554

100099.354

	2205340.844

2166652.679	17677062.8099

	28.523

CM-03

	Exhaled VOC Trap 1  	  3 h

	17.5195

	25.2592

	7.7397

	0.0457

0.0492 	74391.22

76154.17	25.67

25.67	74365.554

76128.504

	1627255.005

1547327.312	12285157.3812

	19.823

CM-03

	Exhaled VOC Trap 1  	  6 h

	17.6374

	25.3807

	7.7433

	0.0479

0.0469 	53799.01

52072.05	25.67

25.67	53773.344

52046.384

	1122616.780

1109730.997	8642869.2691

	13.946

CM-03

	Exhaled VOC Trap 1  	 24 h

	17.9299

	25.7339

	7.8040

	0.0486

0.0497 	22022.07

22080.24	25.67

25.67	21996.404

22054.574

	452600.900

443753.999	3497576.8167

	5.644

CM-03

	Exhaled VOC Trap 1  	 48 h

	17.6796

	21.4889

	3.8093

	0.0478

0.0484 	545.00

551.15	25.59

25.59	519.408

525.558

	10866.266

10858.626	41378.3150

	0.067

CM-03

	Exhaled VOC Trap 1  	 72 h

	17.6713

	21.4801

	3.8088

	0.0490

0.0484 	167.96

173.29	25.59

25.59	142.368

147.698

	2905.459

3051.601	11344.6259

	0.018

CM-03

	Exhaled VOC Trap 1  	 96 h

	17.7283

	21.6241

	3.8958

	0.0486

0.0483 	102.20

101.46	26.58

26.58	75.616

74.876

	1555.885

1550.228	6050.3966

	0.010

CM-03

	Exhaled VOC Trap 1  	120 h

	17.5743

	21.4510

	3.8767

	0.0453

0.0449 	71.37

72.05	26.58

26.58	44.786

45.466

	*

*	988.653

1012.606	3879.1408

	0.006

CM-03

	Exhaled VOC Trap 1  	144 h

	17.5994

	21.5116

	3.9122

	0.0457

0.0481 	62.68

59.05	26.58

26.58	36.096

32.466

	*

*	789.847

674.969	2865.3259

	0.005

CM-03

	Exhaled VOC Trap 1  	168 h

	17.7335

	21.6304

	3.8969

	0.0458

0.0480 	48.47

61.56	25.67

25.67	22.797

35.887

	*

*	497.744

747.639	2426.5659

	0.004

a Samples from CM-04 were not analyzed.

* in LOD column indicates that sample DPM were less than background DPM, and in LOQ column indicates that sample DPM was less than 3 x background.

Table 9.  Recovery of Radioactivity in VOC Trap 2 from Group C.

Subject	Sample	Time	Pot wt	Samp wt	Corr Samp	Alq wt	Orig DPM	Bkg DPM Calc DPM	LOD	LOQ	DPM/g	Sample DPM	Reco (%)

CM-01

	Exhaled VOC Trap 2  	  1 h

	17.2870

	25.0071

	7.7201

	0.0473

0.0459 	31.00

31.97	25.67

25.67	5.334

6.304

	*

*	112.764

137.337	965.4019

	0.002

CM-01

	Exhaled VOC Trap 2  	  3 h

	17.3408

	25.1146

	7.7738

	0.0472

0.0474 	39.11

34.60	25.67

25.67	13.444

8.934

	*

*	284.825

188.476	1839.6735

	0.003

CM-01

	Exhaled VOC Trap 2  	  6 h

	17.4090

	25.1304

	7.7214

	0.0476

0.0453 	34.18

25.69	25.67

25.67	8.514

0.024

	*

*	178.860

0.524	692.5500

	0.001

CM-01

	Exhaled VOC Trap 2  	 24 h

	17.6242

	25.4035

	7.7793

	0.0456

0.0483 	18230.11

17956.97	25.67

25.67	18204.444

17931.304

	399220.258

371248.525	2996853.8999

	5.426

CM-01

	Exhaled VOC Trap 2  	 48 h

	17.7448

	21.5501

	3.8053

	0.0477

0.0479 	51.12

44.42	25.59

25.59	25.528

18.828

	*

*	535.168

393.058	1766.0895

	0.003

CM-01

	Exhaled VOC Trap 2  	 72 h

	17.7050

	21.5138

	3.8088

	0.0483

0.0489 	30.73

30.07	25.59

25.59	5.138

4.478

	*

*	106.366

91.564	376.9396

	0.001

CM-01

	Exhaled VOC Trap 2  	 96 h

	17.4716

	21.3689

	3.8973

	0.0486

0.0461 	30.75

31.00	26.58

26.58	4.166

4.416

	*

*	85.720

95.792	353.7032

	0.001

CM-01

	Exhaled VOC Trap 2  	120 h

	17.6334

	21.5254

	3.8920

	0.0470

0.0473 	31.23

28.06	26.58

26.58	4.646

1.476

	*

*	98.851

31.205	253.0892

	0.000

CM-01

	Exhaled VOC Trap 2  	144 h

	17.6692

	21.5887

	3.9195

	0.0478

0.0472 	27.41

25.84	26.58

26.58	0.826

0.000	*

*

	17.280

0.000	33.8651

	0.000

CM-01

	Exhaled VOC Trap 2  	168 h

	17.7720

	21.6849

	3.9129

	0.0477

0.0484 	25.14

27.80	25.67

25.67	0.000

2.127	*

*

	0.000

43.939	85.9652

	0.000

CM-02

	Exhaled VOC Trap 2  	  1 h

	17.3715

	25.1200

	7.7485

	0.0469

0.0454 	35.90

36.32	25.67

25.67	10.234

10.654

	*

*	218.204

234.664	1754.5228

	0.003

CM-02

	Exhaled VOC Trap 2  	  3 h

	17.4032

	25.1312

	7.7280

	0.0471

0.0491 	39.92

40.17	25.67

25.67	14.254

14.504

	*

*	302.627

295.392	2310.7471

	0.004

CM-02

	Exhaled VOC Trap 2  	  6 h

	17.5781

	25.3211

	7.7430

	0.0484

0.0467 	48.46

43.98	25.67

25.67	22.794

18.314

	*

*	470.945

392.157	3341.5019

	0.006

CM-02

	Exhaled VOC Trap 2  	 24 h

	17.7019

	25.4820

	7.7801

	0.0490

0.0488 	14165.28

13924.75	25.67

25.67	14139.614

13899.084

	288563.546

284817.290	2230480.1206

	3.872

CM-02

	Exhaled VOC Trap 2  	 48 h

	17.6271

	21.4378

	3.8107

	0.0475

0.0490 	56.54

67.04	25.59

25.59	30.948

41.448

	*

*	651.526

845.867	2853.0590

	0.005

CM-02

	Exhaled VOC Trap 2  	 72 h

	17.6103

	21.4186

	3.8083

	0.0478

0.0488 	31.18

30.71	25.59

25.59	5.588

5.118

	*

*	116.893

104.867	422.2645

	0.001

CM-02

	Exhaled VOC Trap 2  	 96 h

	17.6750

	21.5940

	3.9190

	0.0454

0.0428 	32.99

27.39	26.58

26.58	6.406

0.806

	*

*	141.101

18.832	313.3889

	0.001

CM-02

	Exhaled VOC Trap 2  	120 h

	17.6740

	21.5859

	3.9119

	0.0476

0.0483 	25.36

30.32	26.58

26.58	0.000

3.736	*

*

	0.000

77.350	151.2925

	0.000

CM-02

	Exhaled VOC Trap 2  	144 h

	17.6951

	21.6186

	3.9235

	0.0459

0.0487 	33.24

28.52	26.58

26.58	6.656

1.936

	*

*	145.011

39.754	362.4617

	0.001

CM-02

	Exhaled VOC Trap 2

	168 h

	17.6282

	21.6312

	4.0030

	0.0458

0.0488 	26.96

26.75	25.67

25.67	1.287

1.077

	*

*	28.093

22.063	100.3872

	0.000

Table 9 (contd).  Recovery of Radioactivity in VOC Trap 2 from Group C.

Subject	Sample	Time	Pot wt	Samp wt	Corr Samp	Alq wt	Orig DPM	Bkg DPM Calc DPM	LOD	LOQ	DPM/g	Sample DPM	Reco (%)

CM-03

	Exhaled VOC Trap 2  	  1 h

	17.3866

	25.1682

	7.7816

	0.0465

0.0443 	35.47

36.14	25.67

25.67	9.804

10.474

	*

*	210.833

236.428	1740.2035

	0.003

CM-03

	Exhaled VOC Trap 2  	  3 h

	17.3954

	25.1348

	7.7394

	0.0486

0.0448 	41.02

39.29	25.67

25.67	15.354

13.624

	*

*	315.921

304.102	2399.3005

	0.004

CM-03

	Exhaled VOC Trap 2  	  6 h

	17.5554

	25.3039

	7.7485

	0.0479

0.0481 	41.73

46.66	25.67

25.67	16.064

20.994

	*

*	335.360

436.460	2990.2261

	0.005

CM-03

	Exhaled VOC Trap 2  	 24 h

	17.2213

	24.9328

	7.7115

	0.0475

0.0477 	27.57

25.34	28.57

28.57	0.000

0.000	*

*

	0.000

0.000	0.0000

	0.000

CM-03

	Exhaled VOC Trap 2  	 48 h

	17.6937

	21.5069

	3.8132

	0.0477

0.0476 	4014.48

3934.03	25.59

25.59	3988.888

3908.438

	83624.476

82110.032<PHONE_NUMBER>

	0.510

CM-03

	Exhaled VOC Trap 2  	 72 h

	17.7882

	21.6101

	3.8219

	0.0475

0.0495 	26.22

29.61	25.59

25.59	0.627

4.018

	*

*	13.211

81.162	180.3404

	0.000

CM-03

	Exhaled VOC Trap 2  	 96 h

	17.5522

	21.4615

	3.9093

	0.0467

0.0467 	25.79

26.04	26.58

26.58	0.000

0.000	*

*

	0.000

0.000	0.0000

	0.000

CM-03

	Exhaled VOC Trap 2  	120 h

	17.7909

	21.6904

	3.8995

	0.0463

0.0475 	26.48

25.16	26.58

26.58	0.000

0.000	*

*

	0.000

0.000	0.0000

	0.000

CM-03

	Exhaled VOC Trap 2  	144 h

	17.6494

	21.5537

	3.9043

	0.0477

0.0493 	26.48

24.69	26.58

26.58	0.000

0.000	*

*

	0.000

0.000	0.0000

	0.000

CM-03

	Exhaled VOC Trap 2  	168 h

	17.5559

	21.4776

	3.9217

	0.0485

0.0474 	22.91

30.93	25.67

25.67	0.000

5.257	*

*

	0.000

110.900	217.4585

	0.000

* in LOD column indicates that sample DPM were less than background DPM, and in LOQ column indicates that sample DPM was less than 3 x background.

Table 10.  Recovery of Radioactivity in Nose Only Tube Rinse from Group C.

Subject	Sample	Time	Pot wt	Samp wt	Corr Samp	Alq wt	Orig DPM	Bkg DPM Calc DPM	LOD	LOQ	DPM/g	Sample DPM	Reco (%)

CM-01

CM-01

	Nose Only Tube Rinse

Cage Rinse

	  0 h

168 h

	227.64

291.92

	296.44

563.41

	68.80

271.49

	0.5421

0.8379

0.5657 0.5431

0.4799 	951.59

1458.96

980.6976.81

71.62	0.92

0.92

0.9233.22

33.22	950.670

1458.040

979.77043.590

38.400

*

*	1753.680

1740.112

1731.96080.261

80.017	119843.93

 21756.9550

	0.217

 0.039

CM-02

CM-02

	Nose Only Tube Rinse

Cage Rinse

	  0 h

168 h

	229.08

290.04

	334.99

492.84

	105.91

202.80

	0.5700

0.5653

0.5704 0.5662

0.5789 	565.56

582.71

592.1093.38

100.62	0.92

0.92

0.9233.22

33.22	564.640

581.790

591.18060.160

67.400

*

*	990.596

1029.170

1036.431106.252

116.428	107893.96

 22579.7434

	0.187

 0.039

CM-03

CM-03

	Nose Only Tube Rinse

Cage Rinse

	  0 h

168 h

	228.50

290.11

	347.05

525.72

	118.55

235.61

	0.5328

0.5842

0.5047 0.6135

0.5854 	969.56

1072.25

923.5495.84

86.30	0.92

0.92

0.9233.22

33.22	968.640

1071.330

922.62062.620

53.080

*

*	1818.018

1833.841

1828.056102.070

90.673	216547.99

 22706.1049

	0.349

 0.037

CM-04

CM-04

	Nose Only Tube Rinse

Cage Rinse

	  0 h

168 h

	228.72

290.30

	303.75

588.24

	75.03

297.94

	0.5872

0.5935

0.5891 0.5235

0.6671 	714.90

701.06

738.8269.56

82.54	0.92

0.92

0.9233.22

33.22	713.980

700.140

737.90036.340

49.320

*

*	1215.906

1179.680

1252.58969.417

73.932	91240.85

 21354.7493

	0.596

 0.139

* in LOD column indicates that sample DPM were less than background DPM, and in LOQ column indicates that sample DPM was less than 3 x background.

Table 11.  Recovery of Radioactivity in Cage Rinse from Group C.

Subject	Sample	Time	Pot wt	Samp wt	Corr Samp	Alq wt	Orig DPM	Bkg DPM Calc DPM	LOD	LOQ	DPM/g	Sample DPM	Reco (%)

CM-01

	Cage Rinse

	168 h

	291.92

	563.41

	271.49

	0.5431

0.4799 	76.81

71.62	33.22

33.22	43.590

38.400

	*

*	80.261

80.017	21756.9550

	0.039

CM-02

	Cage Rinse

	168 h

	290.04

	492.84

	202.80

	0.5662

0.5789 	93.38

100.62	33.22

33.22	60.160

67.400

	*

*	106.252

116.428	22579.7434

	0.039

CM-03

	Cage Rinse

	168 h

	290.11

	525.72

	235.61

	0.6135

0.5854 	95.84

86.30	33.22

33.22	62.620

53.080

	*

*	102.070

90.673	22706.1049

	0.037

CM-04

	Cage Rinse

	168 h

	290.30

	588.24

	297.94

	0.5235

0.6671 	69.56

82.54	33.22

33.22	36.340

49.320

	*

*	69.417

73.932	21354.7493

	0.139

* in LOD column indicates that sample DPM were less than background DPM, and in LOQ column indicates that sample DPM was less than 3 x background.

Table 14.  Recovery of Radioactivity in Carcass Digest from Group C.

Subject	Sample	Time	Pot wt	Samp wt	Corr Samp	Homog wt	Corr Homog	Alq wt Orig DPM	Bkg DPM	Calc DPM	LOD	LOQ	DPM/g	Sample DPM	Reco (%)

CM-01

	Carcass Digest

	168 h

	108.43

	298.32

	189.89

	743.25

	634.82

	0.9660

0.7788 	2243.64

1783.77	2.02

2.02	2241.623

1781.753

	2320.521

2287.819	1462733.1726 dpm

	2.649

CM-02

	Carcass Digest

	168 h

	108.49

	264.06

	155.57

	713.15

	604.66

	0.7983

0.7838 	1639.65

1587.32	2.02

2.02	1637.633

1585.303

	2051.401

2022.587	1231688.6221 dpm

	2.138

CM-03

	Carcass Digest

	168 h

	108.50

	321.55

	213.05

	764.55

	656.05

	0.8878

0.7609 	2545.03

2140.18	2.02

2.02	2543.013

2138.163

	2864.399

2810.045	1861359.4966 dpm

	3.003

CM-04

	Carcass Digest

	168 h

	108.96

	308.51

	199.55

	750.02

	641.06

	0.7264

0.7493 	1645.23

1678.70	2.02

2.02	1643.213

1676.683

	2262.133

2237.666	1442320.6245 dpm

	9.419

* in LOD column indicates that sample DPM were less than background DPM, and in LOQ column indicates that sample DPM was less than 3 x background.

Table 15.  Total Recovery of Radioactivity in Samples from Group C.

Subject	Sample	Time	Sample DPM	Sample DPM Sum	Reco (%)

CM-01               	Urine               	  8 h                1702841.2448 dpm	55226372.663 dpm	3.083

CM-01               	Urine               	 24 h                1112436.2962 dpm

2.014

CM-01               	Urine               	 48 h                152192.0689 dpm

0.276

CM-01               	Urine               	 72 h                42766.6875 dpm

0.077

CM-01               	Urine               	 96 h                20639.8664 dpm

0.037

CM-01               	Urine               	120 h                13419.7170 dpm

0.024

CM-01               	Urine               	144 h               	7603.5986 dpm

0.014

CM-01               	Urine               	168 h               	6641.9187 dpm

0.012

CM-01               	Feces               	 24 h                304280.7035 dpm

0.551

CM-01               	Feces               	 48 h                81728.3597 dpm

0.148

CM-01               	Feces               	 72 h                100278.6765 dpm

0.182

CM-01               	Feces               	 96 h                33489.1935 dpm

0.061

CM-01               	Feces               	120 h                20229.3497 dpm

0.037

CM-01               	Feces               	144 h                23794.9089 dpm

0.043

CM-01               	Feces               	168 h                15669.0866 dpm

0.028

CM-01               	Carcass Digest      	168 h                1462733.1726 dpm

2.649

CM-01               	CO2 Trap 1          	  1 h                246942.5678 dpm

0.447

CM-01               	CO2 Trap 1          	  3 h               	9585.5499 dpm

0.017

CM-01               	CO2 Trap 1          	  6 h                1696930.6986 dpm

3.073

CM-01               	CO2 Trap 1          	 24 h                6774444.4008 dpm

12.267

CM-01               	CO2 Trap 1          	 48 h                464233.7551 dpm

0.841

CM-01               	CO2 Trap 1          	 72 h                229702.9637 dpm

0.416

CM-01               	CO2 Trap 1          	 96 h                102737.2420 dpm

0.186

CM-01               	CO2 Trap 1          	120 h                82608.7736 dpm

0.150

CM-01               	CO2 Trap 1          	144 h                55310.4673 dpm

0.100

CM-01               	CO2 Trap 1          	168 h                37459.6609 dpm

0.068

CM-01               	CO2 Trap 2          	  1 h               	325.2943 dpm

0.001

CM-01               	CO2 Trap 2          	  3 h                698451.4452 dpm

1.265

CM-01               	CO2 Trap 2          	  6 h               	7421.3663 dpm

0.013

CM-01               	CO2 Trap 2          	 24 h                509232.8427 dpm

0.922

CM-01               	CO2 Trap 2          	 48 h                114228.1428 dpm

0.207

CM-01               	CO2 Trap 2          	 72 h                60433.0240 dpm

0.109

CM-01               	CO2 Trap 2          	 96 h                32245.2092 dpm

0.058

CM-01               	CO2 Trap 2          	120 h                21167.2592 dpm

0.038

CM-01               	CO2 Trap 2          	144 h                22190.9255 dpm

0.040

CM-01               	CO2 Trap 2          	168 h                18345.3295 dpm

0.033

CM-01               	Exhaled VOC Trap 1  	  1 h                16241940.2899 dpm

29.410

CM-01               	Exhaled VOC Trap 1  	  3 h                10063540.9441 dpm

18.222

CM-01               	Exhaled VOC Trap 1  	  6 h                7162686.5449 dpm

12.970

CM-01               	Exhaled VOC Trap 1  	 24 h                2267187.7811 dpm

4.105

CM-01               	Exhaled VOC Trap 1  	 48 h                26940.0076 dpm

0.049

CM-01               	Exhaled VOC Trap 1  	 72 h                10533.6467 dpm

0.019

CM-01               	Exhaled VOC Trap 1  	 96 h               	4981.5398 dpm

0.009

CM-01               	Exhaled VOC Trap 1  	120 h               	3418.5760 dpm

0.006

CM-01               	Exhaled VOC Trap 1  	144 h               	2555.5591 dpm

0.005

CM-01               	Exhaled VOC Trap 1  	168 h               	2092.2389 dpm

0.004

CM-01               	Exhaled VOC Trap 2  	  1 h               	965.4019 dpm

0.002

CM-01               	Exhaled VOC Trap 2  	  3 h               	1839.6735 dpm

0.003

CM-01               	Exhaled VOC Trap 2  	  6 h               	692.5500 dpm

0.001

CM-01               	Exhaled VOC Trap 2  	 24 h                2996853.8999 dpm

5.426

CM-01               	Exhaled VOC Trap 2  	 48 h               	1766.0895 dpm

0.003

CM-01               	Exhaled VOC Trap 2  	 72 h               	376.9396 dpm

0.001

CM-01               	Exhaled VOC Trap 2  	 96 h               	353.7032 dpm

0.001

CM-01               	Exhaled VOC Trap 2  	120 h               	253.0892 dpm

0.000

CM-01               	Exhaled VOC Trap 2  	144 h               	33.8651 dpm

0.000

CM-01               	Exhaled VOC Trap 2  	168 h               	85.9652 dpm

0.000

CM-01               	Cage Rinse          	168 h                21756.9550 dpm

0.039

CM-01               	Exposure Urine      	  0 h               	N.C.

 N.A.

CM-01               	Exposure Feces      	  0 h                10931.7067 dpm

0.020

CM-01               	Nose Only Tube Rinse	  0 h                119843.9291 dpm

0.217

Table 15 (contd).  Total Recovery of Radioactivity in Samples from Group C.

Subject	Sample	Time	Sample DPM	Sample DPM Sum	Reco (%)

CM-02               	Urine               	  8 h                1724425.4933 dpm	57600304.435 dpm	2.994

CM-02               	Urine               	 24 h                513448.6599 dpm

0.891

CM-02               	Urine               	 48 h                99729.5573 dpm

0.173

CM-02               	Urine               	 72 h                45884.1258 dpm

0.080

CM-02               	Urine               	 96 h                25830.8763 dpm

0.045

CM-02               	Urine               	120 h                13301.0590 dpm

0.023

CM-02               	Urine               	144 h               	8136.5127 dpm

0.014

CM-02               	Urine               	168 h               	8278.3864 dpm

0.014

CM-02               	Feces               	 24 h                212846.8639 dpm

0.370

CM-02               	Feces               	 48 h                106287.4716 dpm

0.185

CM-02               	Feces               	 72 h                72685.7237 dpm

0.126

CM-02               	Feces               	 96 h                28211.6997 dpm

0.049

CM-02               	Feces               	120 h                30004.6363 dpm

0.052

CM-02               	Feces               	144 h                19753.2879 dpm

0.034

CM-02               	Feces               	168 h                19853.2934 dpm

0.034

CM-02               	Carcass Digest      	168 h                1231688.6221 dpm

2.138

CM-02               	CO2 Trap 1          	  1 h                239877.4440 dpm

0.416

CM-02               	CO2 Trap 1          	  3 h                680035.5272 dpm

1.181

CM-02               	CO2 Trap 1          	  6 h                2064541.3872 dpm

3.584

CM-02               	CO2 Trap 1          	 24 h                6471455.9649 dpm

11.235

CM-02               	CO2 Trap 1          	 48 h                354163.2880 dpm

0.615

CM-02               	CO2 Trap 1          	 72 h                139928.4295 dpm

0.243

CM-02               	CO2 Trap 1          	 96 h                85187.3860 dpm

0.148

CM-02               	CO2 Trap 1          	120 h                60304.5536 dpm

0.105

CM-02               	CO2 Trap 1          	144 h                57990.6625 dpm

0.101

CM-02               	CO2 Trap 1          	168 h                37901.8063 dpm

0.066

CM-02               	CO2 Trap 2          	  1 h               	1228.6300 dpm

0.002

CM-02               	CO2 Trap 2          	  3 h               	6468.1692 dpm

0.011

CM-02               	CO2 Trap 2          	  6 h                12449.4979 dpm

0.022

CM-02               	CO2 Trap 2          	 24 h                323859.8783 dpm

0.562

CM-02               	CO2 Trap 2          	 48 h                131217.5367 dpm

0.228

CM-02               	CO2 Trap 2          	 72 h                78774.4871 dpm

0.137

CM-02               	CO2 Trap 2          	 96 h                44309.3432 dpm

0.077

CM-02               	CO2 Trap 2          	120 h                38785.5875 dpm

0.067

CM-02               	CO2 Trap 2          	144 h                21421.1500 dpm

0.037

CM-02               	CO2 Trap 2          	168 h                16709.1902 dpm

0.029

CM-02               	Exhaled VOC Trap 1  	  1 h                19776671.7311 dpm

34.334

CM-02               	Exhaled VOC Trap 1  	  3 h                12141553.0411 dpm

21.079

CM-02               	Exhaled VOC Trap 1  	  6 h                7333740.3866 dpm

12.732

CM-02               	Exhaled VOC Trap 1  	 24 h                699718.1910 dpm

1.215

CM-02               	Exhaled VOC Trap 1  	 48 h                20939.6603 dpm

0.036

CM-02               	Exhaled VOC Trap 1  	 72 h                14866.8688 dpm

0.026

CM-02               	Exhaled VOC Trap 1  	 96 h                10938.1387 dpm

0.019

CM-02               	Exhaled VOC Trap 1  	120 h               	5960.0466 dpm

0.010

CM-02               	Exhaled VOC Trap 1  	144 h               	4682.9841 dpm

0.008

CM-02               	Exhaled VOC Trap 1  	168 h               	3402.8124 dpm

0.006

CM-02               	Exhaled VOC Trap 2  	  1 h               	1754.5228 dpm

0.003

CM-02               	Exhaled VOC Trap 2  	  3 h               	2310.7471 dpm

0.004

CM-02               	Exhaled VOC Trap 2  	  6 h               	3341.5019 dpm

0.006

CM-02               	Exhaled VOC Trap 2  	 24 h                2230480.1206 dpm

3.872

CM-02               	Exhaled VOC Trap 2  	 48 h               	2853.0590 dpm

0.005

CM-02               	Exhaled VOC Trap 2  	 72 h               	422.2645 dpm

0.001

CM-02               	Exhaled VOC Trap 2  	 96 h               	313.3889 dpm

0.001

CM-02               	Exhaled VOC Trap 2  	120 h               	151.2925 dpm

0.000

CM-02               	Exhaled VOC Trap 2  	144 h               	362.4617 dpm

0.001

CM-02               	Exhaled VOC Trap 2  	168 h               	100.3872 dpm

0.000

CM-02               	Blood               	168 h               	772.7276 dpm

0.001

CM-02               	Spleen              	168 h               	2713.8934 dpm

0.005

Table 15 (contd).  Total Recovery of Radioactivity in Samples from Group C.

CM-02               	Liver               	168 h                68605.0539 dpm

0.119

CM-02               	Kidney              	168 h                14078.4226 dpm

0.024

CM-02               	Brain               	168 h               	8225.5161 dpm

0.014

CM-02               	Heart               	168 h               	3921.6704 dpm

0.007

CM-02               	Lung                	168 h               	7171.9886 dpm

0.012

CM-02               	Stomach             	168 h               	6507.6618 dpm

0.011

CM-02               	Small Intestine     	168 h                15092.2206 dpm

0.026

CM-02               	Femur               	168 h               	3312.0956 dpm

0.006

CM-02               	Testes              	168 h                14999.9728 dpm

0.026

CM-02               	Cecum+Lg Int+Rect   	168 h                10720.4814 dpm

0.019

CM-02               	Adip (Abdominal)    	168 h               	3212.4929 dpm

0.006

CM-02               	Cage Rinse          	168 h                22579.7434 dpm

0.039

CM-02               	Skin (Neck)         	168 h               	2992.3947 dpm

0.005

CM-02               	Adipose (subcut)    	168 h               	3668.5436 dpm

0.006

CM-02               	Stomach Contents    	168 h               	604.4376 dpm

0.001

CM-02               	Muscle Gastrocnemius	168 h               	2454.9885 dpm

0.004

CM-02               	Small Intestine Cont	168 h                10854.0784 dpm

0.019

CM-02               	Lg Int + Cecum Cont 	168 h               	8382.2992 dpm

0.015

CM-02               	Exposure Urine      	  0 h               	N.C.

 N.A.

CM-02               	Exposure Feces      	  0 h               	N.C.

 N.A.

CM-02               	Nose Only Tube Rinse	  0 h                107893.9562 dpm

0.187

Table 15 (contd).  Total Recovery of Radioactivity in Samples from Group C.

Subject	Sample	Time	Sample DPM	Sample DPM Sum	Reco (%)

CM-03               	Urine               	  8 h                1830907.9353 dpm	61974739.573 dpm	2.954

CM-03               	Urine               	 24 h                1035036.8761 dpm

1.670

CM-03               	Urine               	 48 h                94140.8610 dpm

0.152

CM-03               	Urine               	 72 h                36422.3233 dpm

0.059

CM-03               	Urine               	 96 h                21467.4863 dpm

0.035

CM-03               	Urine               	120 h                12046.4569 dpm

0.019

CM-03               	Urine               	144 h                11128.9383 dpm

0.018

CM-03               	Urine               	168 h               	6406.4016 dpm

0.010

CM-03               	Feces               	 24 h                526783.7049 dpm

0.850

CM-03               	Feces               	 48 h                153155.1821 dpm

0.247

CM-03               	Feces               	 72 h                53383.2190 dpm

0.086

CM-03               	Feces               	 96 h                80773.0200 dpm

0.130

CM-03               	Feces               	120 h                30611.1993 dpm

0.049

CM-03               	Feces               	144 h               	7816.8261 dpm

0.013

CM-03               	Feces               	168 h                38406.6001 dpm

0.062

CM-03               	Carcass Digest      	168 h                1861359.4966 dpm

3.003

CM-03               	CO2 Trap 1          	  1 h                236323.1407 dpm

0.381

CM-03               	CO2 Trap 1          	  3 h                666619.0295 dpm

1.076

CM-03               	CO2 Trap 1          	  6 h                2227004.5358 dpm

3.593

CM-03               	CO2 Trap 1          	 24 h                7612540.0951 dpm

12.283

CM-03               	CO2 Trap 1          	 48 h                739592.7459 dpm

1.193

CM-03               	CO2 Trap 1          	 72 h                247644.9995 dpm

0.400

CM-03               	CO2 Trap 1          	 96 h                127633.4003 dpm

0.206

CM-03               	CO2 Trap 1          	120 h                112926.1187 dpm

0.182

CM-03               	CO2 Trap 1          	144 h                90463.3291 dpm

0.146

CM-03               	CO2 Trap 1          	168 h                52132.9559 dpm

0.084

CM-03               	CO2 Trap 2          	  1 h               	1179.8598 dpm

0.002

CM-03               	CO2 Trap 2          	  3 h               	5537.2663 dpm

0.009

CM-03               	CO2 Trap 2          	  6 h                16930.4947 dpm

0.027

CM-03               	CO2 Trap 2          	 24 h                776560.8440 dpm

1.253

CM-03               	CO2 Trap 2          	 48 h                258008.2599 dpm

0.416

CM-03               	CO2 Trap 2          	 72 h                82975.0407 dpm

0.134

CM-03               	CO2 Trap 2          	 96 h                42802.4303 dpm

0.069

CM-03               	CO2 Trap 2          	120 h                22766.1409 dpm

0.037

CM-03               	CO2 Trap 2          	144 h                27059.2818 dpm

0.044

CM-03               	CO2 Trap 2          	168 h                22151.0729 dpm

0.036

CM-03               	Exhaled VOC Trap 1  	  1 h                17677062.8099 dpm

28.523

CM-03               	Exhaled VOC Trap 1  	  3 h                12285157.3812 dpm

19.823

CM-03               	Exhaled VOC Trap 1  	  6 h                8642869.2691 dpm

13.946

CM-03               	Exhaled VOC Trap 1  	 24 h                3497576.8167 dpm

5.644

CM-03               	Exhaled VOC Trap 1  	 48 h                41378.3150 dpm

0.067

CM-03               	Exhaled VOC Trap 1  	 72 h                11344.6259 dpm

0.018

CM-03               	Exhaled VOC Trap 1  	 96 h               	6050.3966 dpm

0.010

CM-03               	Exhaled VOC Trap 1  	120 h               	3879.1408 dpm

0.006

CM-03               	Exhaled VOC Trap 1  	144 h               	2865.3259 dpm

0.005

CM-03               	Exhaled VOC Trap 1  	168 h               	2426.5659 dpm

0.004

CM-03               	Exhaled VOC Trap 2  	  1 h               	1740.2035 dpm

0.003

CM-03               	Exhaled VOC Trap 2  	  3 h               	2399.3005 dpm

0.004

CM-03               	Exhaled VOC Trap 2  	  6 h               	2990.2261 dpm

0.005

CM-03               	Exhaled VOC Trap 2  	 24 h               	0.0000 dpm

0.000

CM-03               	Exhaled VOC Trap 2  	 48 h                315989.4118 dpm

0.510

CM-03               	Exhaled VOC Trap 2  	 72 h               	180.3404 dpm

0.000

CM-03               	Exhaled VOC Trap 2  	 96 h               	0.0000 dpm

0.000

CM-03               	Exhaled VOC Trap 2  	120 h               	0.0000 dpm

0.000

CM-03               	Exhaled VOC Trap 2  	144 h               	0.0000 dpm

0.000

CM-03               	Exhaled VOC Trap 2  	168 h               	217.4585 dpm

0.000

CM-03               	Cage Rinse          	168 h                22706.1049 dpm

0.037

CM-03               	Exposure Urine      	  0 h               	N.C.

 N.A.

CM-03               	Exposure Feces      	  0 h                72660.3202 dpm

0.117

CM-03               	Nose Only Tube Rinse	  0 h                216547.9918 dpm

0.349

Table 15 (contd).  Total Recovery of Radioactivity in Samples from Group C.

Subject	Sample	Time	Sample DPM	Sample DPM Sum	Reco (%)

CM-04               	Urine               	  8 h                989422.8048 dpm	15313501.108 dpm	6.461

CM-04               	Urine               	 24 h                1337202.8125 dpm

8.732

CM-04               	Urine               	 48 h                183682.3569 dpm

1.199

CM-04               	Urine               	 72 h                39186.3623 dpm

0.256

CM-04               	Urine               	 96 h                13567.7919 dpm

0.089

CM-04               	Urine               	120 h                11819.8278 dpm

0.077

CM-04               	Urine               	144 h               	9219.9960 dpm

0.060

CM-04               	Urine               	168 h               	7059.9188 dpm

0.046

CM-04               	Feces               	 24 h                284923.2872 dpm

1.861

CM-04               	Feces               	 48 h                108474.3403 dpm

0.708

CM-04               	Feces               	 72 h                43780.5359 dpm

0.286

CM-04               	Feces               	 96 h                61476.9369 dpm

0.401

CM-04               	Feces               	120 h                23743.7041 dpm

0.155

CM-04               	Feces               	144 h                18835.1115 dpm

0.123

CM-04               	Feces               	168 h                16712.6327 dpm

0.109

CM-04               	Carcass Digest      	168 h                1442320.6245 dpm

9.419

CM-04               	CO2 Trap 1          	  1 h                244957.6956 dpm

1.600

CM-04               	CO2 Trap 1          	  3 h                722853.7853 dpm

4.720

CM-04               	CO2 Trap 1          	  6 h                1734658.5733 dpm

11.328

CM-04               	CO2 Trap 1          	 24 h                6059912.7649 dpm

39.572

CM-04               	CO2 Trap 1          	 48 h                392843.3036 dpm

2.565

CM-04               	CO2 Trap 1          	 72 h                186883.0429 dpm

1.220

CM-04               	CO2 Trap 1          	 96 h                116115.8257 dpm

0.758

CM-04               	CO2 Trap 1          	120 h                82913.4703 dpm

0.541

CM-04               	CO2 Trap 1          	144 h                62329.0532 dpm

0.407

CM-04               	CO2 Trap 1          	168 h                40464.7951 dpm

0.264

CM-04               	CO2 Trap 2          	  1 h               	224.0153 dpm

0.001

CM-04               	CO2 Trap 2          	  3 h               	2323.2219 dpm

0.015

CM-04               	CO2 Trap 2          	  6 h                11512.7544 dpm

0.075

CM-04               	CO2 Trap 2          	 24 h                631742.0214 dpm

4.125

CM-04               	CO2 Trap 2          	 48 h                144632.5680 dpm

0.944

CM-04               	CO2 Trap 2          	 72 h                68123.3236 dpm

0.445

CM-04               	CO2 Trap 2          	 96 h                35297.7887 dpm

0.231

CM-04               	CO2 Trap 2          	120 h                24766.1932 dpm

0.162

CM-04               	CO2 Trap 2          	144 h                18352.8805 dpm

0.120

CM-04               	CO2 Trap 2          	168 h                15180.6258 dpm

0.099

CM-04               	Exhaled VOC Trap 1  	  1 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 1  	  3 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 1  	  6 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 1  	 24 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 1  	 48 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 1  	 72 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 1  	 96 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 1  	120 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 1  	144 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 1  	168 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 2  	  1 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 2  	  3 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 2  	  6 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 2  	 24 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 2  	 48 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 2  	 72 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 2  	 96 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 2  	120 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 2  	144 h               	N.C.

 N.A.

CM-04               	Exhaled VOC Trap 2  	168 h               	N.C.

 N.A.

CM-04               	Cage Rinse          	168 h                21354.7493 dpm

0.139

CM-04               	Exposure Urine      	  0 h               	N.C.

 N.A.

CM-04               	Exposure Feces      	  0 h                13388.7664 dpm

0.087

CM-04               	Nose Only Tube Rinse	  0 h                91240.8456 dpm

0.596

Appendix I

Blood Sample Collection and Analysis for DIPE, Acetone and Isopropanol Table 1.  Blood Sample Collection Times.

Subject	Sample	Dose Time	Nominal

Time	Elapsed Time

(hh:mm:ss)	Capture Time

	AM-01	Blood	No Dose	Predose	NA	9/27/2007 8:42:04 AM

AM-02	Blood	No Dose	Predose	NA	9/27/2007 8:46:04 AM

AM-03	Blood	No Dose	Predose	NA	9/27/2007 8:51:53 AM

AM-04	Blood	No Dose	Predose	NA	9/27/2007 8:56:58 AM

AM-05	Blood	No Dose	Predose	NA	9/27/2007 9:01:48 AM

AM-06	Blood	No Dose	Predose	NA	9/27/2007 9:06:53 AM

AM-07	Blood	No Dose	Predose	NA	9/27/2007 9:43:54 AM

AM-08	Blood	No Dose	Predose	NA	9/27/2007 9:49:50 AM

AF-01	Blood	No Dose	Predose	NA	9/27/2007 9:10:32 AM

AF-02	Blood	No Dose	Predose	NA	9/27/2007 9:17:04 AM

AF-03	Blood	No Dose	Predose	NA	9/27/2007 9:22:33 AM

AF-04	Blood	No Dose	Predose	NA	9/27/2007 9:27:41 AM

AF-05	Blood	No Dose	Predose	NA	9/27/2007 9:32:50 AM

AF-06	Blood	No Dose	Predose	NA	9/27/2007 9:37:48 AM

AF-07	Blood	No Dose	Predose	NA	9/27/2007 9:54:48 AM

AF-08	Blood	No Dose	Predose	NA	9/27/2007 10:00:43 AM

AM-01	Blood	9/27/2007 9:45:07 AM	5 m	0 h  5 m  11 s	9/27/2007 9:50:18 AM

AM-01	Blood	9/27/2007 9:45:07 AM	15 m	0 h  15 m  26 s	9/27/2007 10:00:33 AM

AM-01	Blood	9/27/2007 9:45:07 AM	1 h	1 h  4 m  29 s	9/27/2007 10:49:36 AM

AM-02	Blood	9/27/2007 9:49:10 AM	5 m	0 h  4 m  47 s	9/27/2007 9:53:57 AM

AM-02	Blood	9/27/2007 9:49:10 AM	15 m	0 h  15 m  16 s	9/27/2007 10:04:26 AM

AM-02	Blood	9/27/2007 9:49:10 AM	1 h	1 h  0 m  29 s	9/27/2007 10:49:39 AM

AM-03	Blood	9/27/2007 9:53:01 AM	5 m	0 h  5 m  43 s	9/27/2007 9:58:44 AM

AM-03	Blood	9/27/2007 9:53:01 AM	15 m	0 h  15 m  12 s	9/27/2007 10:08:13 AM

AM-03	Blood	9/27/2007 9:53:01 AM	1 h	0 h  59 m  58 s	9/27/2007 10:52:59 AM

AM-04	Blood	9/27/2007 9:59:24 AM	10 m	0 h  10 m  25 s	9/27/2007 10:09:49 AM

AM-04	Blood	9/27/2007 9:59:24 AM	30 m	0 h  29 m  29 s	9/27/2007 10:28:53 AM

AM-04	Blood	9/27/2007 9:59:24 AM	2 h	2 h  0 m  13 s	9/27/2007 11:59:37 AM

AM-05	Blood	9/27/2007 10:05:57 AM	10 m	0 h  9 m  33 s	9/27/2007 10:15:30 AM

AM-05	Blood	9/27/2007 10:05:57 AM	30 m	0 h  29 m  1 s	9/27/2007 10:34:58 AM

AM-05	Blood	9/27/2007 10:05:57 AM	2 h	2 h  0 m  30 s	9/27/2007 12:06:27 PM

AM-06	Blood	9/27/2007 10:10:12 AM	10 m	0 h  10 m  14 s	9/27/2007 10:20:26 AM

AM-06	Blood	9/27/2007 10:10:12 AM	30 m	0 h  29 m  56 s	9/27/2007 10:40:08 AM

AM-06	Blood	9/27/2007 10:10:12 AM	2 h	2 h  0 m  2 s	9/27/2007 12:10:14 PM

Table 1 (continued).  Blood Sample Collection Times.

Subject	Sample	Dose Time	Nominal

Time	Elapsed Time

(hh:mm:ss)	Capture Time

	AF-01	Blood	9/27/2007 10:14:32 AM	5 m	0 h  4 m  40 s	9/27/2007 10:19:12 AM

AF-01	Blood	9/27/2007 10:14:32 AM	15 m	0 h  14 m  30 s	9/27/2007 10:29:02 AM

AF-01	Blood	9/27/2007 10:14:32 AM	1 h	0 h  59 m  33 s	9/27/2007 11:14:05 AM

AF-02	Blood	9/27/2007 10:19:07 AM	5 m	0 h  5 m  3 s	9/27/2007 10:24:10 AM

AF-02	Blood	9/27/2007 10:19:07 AM	15 m	0 h  15 m  11 s	9/27/2007 10:34:18 AM

AF-02	Blood	9/27/2007 10:19:07 AM	1 h	1 h  0 m  0 s	9/27/2007 11:19:07 AM

AF-03	Blood	9/27/2007 10:24:59 AM	5 m	0 h  3 m  56 s	9/27/2007 10:28:55 AM

AF-03	Blood	9/27/2007 10:24:59 AM	15 m	0 h  13 m  53 s	9/27/2007 10:38:52 AM

AF-03	Blood	9/27/2007 10:24:59 AM	1 h	1 h  0 m  11 s	9/27/2007 11:25:10 AM

AF-04	Blood	9/27/2007 10:30:31 AM	10 m	0 h  9 m  37 s	9/27/2007 10:40:08 AM

AF-04	Blood	9/27/2007 10:30:31 AM	30 m	0 h  29 m  41 s	9/27/2007 11:00:12 AM

AF-04	Blood	9/27/2007 10:30:31 AM	2 h	2 h  0 m  38 s	9/27/2007 12:31:09 PM

AF-05	Blood	9/27/2007 10:35:13 AM	10 m	0 h  10 m  11 s	9/27/2007 10:45:24 AM

AF-05	Blood	9/27/2007 10:35:13 AM	30 m	0 h  29 m  46 s	9/27/2007 11:04:59 AM

AF-05	Blood	9/27/2007 10:35:13 AM	2 h	2 h  1 m  19 s	9/27/2007 12:36:32 PM

AF-06	Blood	9/27/2007 10:40:17 AM	10 m	0 h  9 m  45 s	9/27/2007 10:50:02 AM

AF-06	Blood	9/27/2007 10:40:17 AM	30 m	0 h  30 m  17 s	9/27/2007 11:10:34 AM

AF-06	Blood	9/27/2007 10:40:17 AM	2 h	2 h  0 m  12 s	9/27/2007 12:40:29 PM

AM-01	Blood	9/27/2007 9:45:07 AM	4 h	4 h  1 m  20 s	9/27/2007 1:46:27 PM

AM-02	Blood	9/27/2007 9:49:10 AM	4 h	3 h  59 m  55 s	9/27/2007 1:49:05 PM

AM-03	Blood	9/27/2007 9:53:01 AM	4 h	4 h  1 m  22 s	9/27/2007 1:54:23 PM

AF-01	Blood	9/27/2007 10:14:32 AM	4 h	4 h  0 m  11 s	9/27/2007 2:14:43 PM

AF-02	Blood	9/27/2007 10:19:07 AM	4 h	4 h  0 m  15 s	9/27/2007 2:19:22 PM

AF-03	Blood	9/27/2007 10:24:59 AM	4 h	3 h  59 m  39 s	9/27/2007 2:24:38 PM

AM-01	Blood	9/27/2007 9:45:07 AM	6.25 h	6 h  15 m  21 s	9/27/2007 4:00:28 PM

AM-01	Blood	9/27/2007 9:45:07 AM	7 h	7 h  0 m  4 s	9/27/2007 4:45:11 PM

AM-01	Blood	9/27/2007 9:45:07 AM	8 h	8 h  0 m  48 s	9/27/2007 5:45:55 PM

AM-02	Blood	9/27/2007 9:49:10 AM	6.25 h	6 h  15 m  14 s	9/27/2007 4:04:24 PM

AM-02	Blood	9/27/2007 9:49:10 AM	7 h	6 h  59 m  54 s	9/27/2007 4:49:04 PM

AM-02	Blood	9/27/2007 9:49:10 AM	8 h	8 h  0 m  2 s	9/27/2007 5:49:12 PM

AM-03	Blood	9/27/2007 9:53:01 AM	6.25 h	6 h  14 m  53 s	9/27/2007 4:07:54 PM

AM-03	Blood	9/27/2007 9:53:01 AM	7 h	6 h  59 m  57 s	9/27/2007 4:52:58 PM

AM-03	Blood	9/27/2007 9:53:01 AM	8 h	8 h  0 m  2 s	9/27/2007 5:53:03 PM

AM-04	Blood	9/27/2007 9:59:24 AM	6 h	6 h  0 m  41 s	9/27/2007 4:00:05 PM

AM-04	Blood	9/27/2007 9:59:24 AM	6.50 h	6 h  29 m  59 s	9/27/2007 4:29:23 PM

AM-04	Blood	9/27/2007 9:59:24 AM	7.33 h	7 h  18 m  37 s	9/27/2007 5:18:01 PM

AM-05	Blood	9/27/2007 10:05:57 AM	6 h	6 h  3 m  19 s	9/27/2007 4:09:16 PM

AM-05	Blood	9/27/2007 10:05:57 AM	6.50 h	6 h  31 m  31 s	9/27/2007 4:37:28 PM

AM-05	Blood	9/27/2007 10:05:57 AM	7.33 h	7 h  18 m  8 s	9/27/2007 5:24:05 PM

AM-06	Blood	9/27/2007 10:10:12 AM	6 h	6 h  0 m  42 s	9/27/2007 4:10:54 PM

AM-06	Blood	9/27/2007 10:10:12 AM	6.50 h	6 h  30 m  40 s	9/27/2007 4:40:52 PM

Table 1 (continued).  Blood Sample Collection Times.

Subject	Sample	Dose Time	Nominal

Time	Elapsed Time

(hh:mm:ss)	Capture Time

	AM-06	Blood	9/27/2007 10:10:12 AM	7.33 h	7 h  18 m  33 s	9/27/2007 5:28:45 PM

AF-01	Blood	9/27/2007 10:14:32 AM	6.25 h	6 h  15 m  14 s	9/27/2007 4:29:46 PM

AF-01	Blood	9/27/2007 10:14:32 AM	7 h	7 h  0 m  24 s	9/27/2007 5:14:56 PM

AF-01	Blood	9/27/2007 10:14:32 AM	8 h	7 h  59 m  38 s	9/27/2007 6:14:10 PM

AF-02	Blood	9/27/2007 10:19:07 AM	6.25 h	6 h  14 m  44 s	9/27/2007 4:33:51 PM

AF-02	Blood	9/27/2007 10:19:07 AM	7 h	6 h  59 m  58 s	9/27/2007 5:19:05 PM

AF-02	Blood	9/27/2007 10:19:07 AM	8 h	7 h  59 m  39 s	9/27/2007 6:18:46 PM

AF-03	Blood	9/27/2007 10:24:59 AM	6.25 h	6 h  15 m  3 s	9/27/2007 4:40:02 PM

AF-03	Blood	9/27/2007 10:24:59 AM	7 h	6 h  59 m  42 s	9/27/2007 5:24:41 PM

AF-03	Blood	9/27/2007 10:24:59 AM	8 h	7 h  59 m  39 s	9/27/2007 6:24:38 PM

AF-04	Blood	9/27/2007 10:30:31 AM	6 h	6 h  0 m  38 s	9/27/2007 4:31:09 PM

AF-04	Blood	9/27/2007 10:30:31 AM	6.50 h	6 h  29 m  5 s	9/27/2007 4:59:36 PM

AF-04	Blood	9/27/2007 10:30:31 AM	7.33 h	7 h  18 m  42 s	9/27/2007 5:49:13 PM

AF-05	Blood	9/27/2007 10:35:13 AM	6 h	6 h  0 m  15 s	9/27/2007 4:35:28 PM

AF-05	Blood	9/27/2007 10:35:13 AM	6.50 h	6 h  29 m  44 s	9/27/2007 5:04:57 PM

AF-05	Blood	9/27/2007 10:35:13 AM	7.33 h	7 h  19 m  1 s	9/27/2007 5:54:14 PM

AF-06	Blood	9/27/2007 10:40:17 AM	6 h	6 h  3 m  36 s	9/27/2007 4:43:53 PM

AF-06	Blood	9/27/2007 10:40:17 AM	6.50 h	6 h  29 m  43 s	9/27/2007 5:10:00 PM

AF-06	Blood	9/27/2007 10:40:17 AM	7.33 h	7 h  19 m  6 s	9/27/2007 5:59:23 PM

AM-04	Blood	9/27/2007 9:59:24 AM	10 h	9 h  59 m  34 s	9/27/2007 7:58:58 PM

AM-05	Blood	9/27/2007 10:05:57 AM	10 h	9 h  59 m  56 s	9/27/2007 8:05:53 PM

AM-06	Blood	9/27/2007 10:10:12 AM	10 h	9 h  59 m  34 s	9/27/2007 8:09:46 PM

AF-04	Blood	9/27/2007 10:30:31 AM	10 h	10 h  0 m  8 s	9/27/2007 8:30:39 PM

AF-05	Blood	9/27/2007 10:35:13 AM	10 h	9 h  59 m  43 s	9/27/2007 8:34:56 PM

AF-06	Blood	9/27/2007 10:40:17 AM	10 h	9 h  59 m  51 s	9/27/2007 8:40:08 PM

AM-01	Blood	9/27/2007 9:45:07 AM	16 h	15 h  59 m  58 s	9/28/2007 1:45:05 AM

AM-02	Blood	9/27/2007 9:49:10 AM	16 h	16 h  0 m  17 s	9/28/2007 1:49:27 AM

AM-03	Blood	9/27/2007 9:53:01 AM	16 h	15 h  59 m  50 s	9/28/2007 1:52:51 AM

AF-01	Blood	9/27/2007 10:14:32 AM	16 h	15 h  59 m  33 s	9/28/2007 2:14:05 AM

AF-02	Blood	9/27/2007 10:19:07 AM	16 h	16 h  0 m  22 s	9/28/2007 2:19:29 AM

AF-03	Blood	9/27/2007 10:24:59 AM	16 h	16 h  0 m  38 s	9/28/2007 2:25:37 AM

AM-04	Blood	9/27/2007 9:59:24 AM	24 h	23 h  59 m  17 s	9/28/2007 9:58:41 AM

AM-05	Blood	9/27/2007 10:05:57 AM	24 h	23 h  59 m  47 s	9/28/2007 10:05:44 AM

AM-06	Blood	9/27/2007 10:10:12 AM	24 h	24 h  1 m  47 s	9/28/2007 10:11:59 AM

AF-04	Blood	9/27/2007 10:30:31 AM	24 h	23 h  59 m  25 s	9/28/2007 10:29:56 AM

AF-05	Blood	9/27/2007 10:35:13 AM	24 h	24 h  0 m  52 s	9/28/2007 10:36:05 AM

AF-06	Blood	9/27/2007 10:40:17 AM	24 h	23 h  59 m  37 s	9/28/2007 10:39:54 AM

Table 2.  Blood Sample Weights from Group A.

Subject	Sample	Time	Pot wt	Sample  wt	Corrected

Sample Weight

AM-01               	Blood               	Predose	11.4071 g	11.5786 g 0.1715 g

AM-01               	Blood               	5 m	11.3700 g	11.5151 g	0.1451 g

AM-01               	Blood               	10 m	N.C.	N.C.	N.C.

AM-01               	Blood               	15 m	11.1686 g	11.3501 g 0.1815 g

AM-01               	Blood               	30 m	N.C.	N.C.	N.C.

AM-01               	Blood               	1 h	11.3947 g	11.5830 g	0.1883 g

AM-01               	Blood               	2 h	N.C.	N.C.	N.C.

AM-01               	Blood               	4 h	11.2188 g	11.4168 g	0.1980 g

AM-01               	Blood               	6 h	N.C.	N.C.	N.C.

AM-01               	Blood               	6.25 h	11.3839 g	11.5485 g 0.1646 g

AM-01               	Blood               	6.50 h	N.C.	N.C.	N.C.

AM-01               	Blood               	7 h	11.3850 g	11.5548 g	0.1698 g

AM-01               	Blood               	7.33 h	N.C.	N.C.	N.C.

AM-01               	Blood               	8 h	11.3953 g	11.5450 g	0.1497 g

AM-01               	Blood               	10 h	N.C.	N.C.	N.C.

AM-01               	Blood               	16 h	11.5298 g	11.6900 g 0.1602 g

AM-01               	Blood               	24 h	N.C.	N.C.	N.C.

AM-02               	Blood               	Predose	11.2103 g	11.3715 g 0.1612 g

AM-02               	Blood               	5 m	11.1642 g	11.3751 g	0.2109 g

AM-02               	Blood               	10 m	N.C.	N.C.	N.C.

AM-02               	Blood               	15 m	11.3748 g	11.5851 g 0.2103 g

AM-02               	Blood               	30 m	N.C.	N.C.	N.C.

AM-02               	Blood               	1 h	11.1905 g	11.4920 g	0.3015 g

AM-02               	Blood               	2 h	N.C.	N.C.	N.C.

AM-02               	Blood               	4 h	11.2054 g	11.3703 g	0.1649 g

AM-02               	Blood               	6 h	N.C.	N.C.	N.C.

AM-02               	Blood               	6.25 h	11.4053 g	11.5638 g 0.1585 g

AM-02               	Blood               	6.50 h	N.C.	N.C.	N.C.

AM-02               	Blood               	7 h	11.1948 g	11.3717 g	0.1769 g

AM-02               	Blood               	7.33 h	N.C.	N.C.	N.C.

AM-02               	Blood               	8 h	11.2456 g	11.3945 g	0.1489 g

AM-02               	Blood               	10 h	N.C.	N.C.	N.C.

AM-02               	Blood               	16 h	11.2549 g	11.4349 g 0.1800 g

AM-02               	Blood               	24 h	N.C.	N.C.	N.C.

Table 2 (contd).  Blood Sample Weights from Group A.

Subject	Sample	Time	Pot wt	Sample  wt	Corrected

Sample Weight

AM-03               	Blood               	Predose	11.3612 g	11.5564 g 0.1952 g

AM-03               	Blood               	5 m	11.1794 g	11.3504 g	0.1710 g

AM-03               	Blood               	10 m	N.C.	N.C.	N.C.

AM-03               	Blood               	15 m	11.3676 g	11.5785 g 0.2109 g

AM-03               	Blood               	30 m	N.C.	N.C.	N.C.

AM-03               	Blood               	1 h	11.1694 g	11.3862 g	0.2168 g

AM-03               	Blood               	2 h	N.C.	N.C.	N.C.

AM-03               	Blood               	4 h	11.2131 g	11.4204 g	0.2073 g

AM-03               	Blood               	6 h	N.C.	N.C.	N.C.

AM-03               	Blood               	6.25 h	11.1978 g	11.3562 g 0.1584 g

AM-03               	Blood               	6.50 h	N.C.	N.C.	N.C.

AM-03               	Blood               	7 h	11.3806 g	11.5546 g	0.1740 g

AM-03               	Blood               	7.33 h	N.C.	N.C.	N.C.

AM-03               	Blood               	8 h	11.2156 g	11.3954 g	0.1798 g

AM-03               	Blood               	10 h	N.C.	N.C.	N.C.

AM-03               	Blood               	16 h	11.1806 g	11.3376 g 0.1570 g

AM-03               	Blood               	24 h	N.C.	N.C.	N.C.

AM-04               	Blood               	Predose	11.3950 g	11.5575 g 0.1625 g

AM-04               	Blood               	5 m	N.C.	N.C.	N.C.

AM-04               	Blood               	10 m	11.2204 g	11.4008 g 0.1804 g

AM-04               	Blood               	15 m	N.C.	N.C.	N.C.

AM-04               	Blood               	30 m	11.1966 g	11.3660 g 0.1694 g

AM-04               	Blood               	1 h	N.C.	N.C.	N.C.

AM-04               	Blood               	2 h	11.2190 g	11.4067 g	0.1877 g

AM-04               	Blood               	4 h	N.C.	N.C.	N.C.

AM-04               	Blood               	6 h	11.2026 g	11.4238 g	0.2212 g

AM-04               	Blood               	6.25 h	N.C.	N.C.	N.C.

AM-04               	Blood               	6.50 h	11.3147 g	11.5023 g 0.1876 g

AM-04               	Blood               	7 h	N.C.	N.C.	N.C.

AM-04               	Blood               	7.33 h	11.2080 g	11.3777 g 0.1697 g

AM-04               	Blood               	8 h	N.C.	N.C.	N.C.

AM-04               	Blood               	10 h	11.1735 g	11.3462 g 0.1727 g

AM-04               	Blood               	16 h	N.C.	N.C.	N.C.

AM-04               	Blood               	24 h	11.2187 g	11.3939 g 0.1752 g

Table 2 (contd).  Blood Sample Weights from Group A.

Subject	Sample	Time	Pot wt	Sample  wt	Corrected

Sample Weight

AM-05               	Blood               	Predose	11.3734 g	11.5553 g 0.1819 g

AM-05               	Blood               	5 m	N.C.	N.C.	N.C.

AM-05               	Blood               	10 m	11.1943 g	11.4195 g 0.2252 g

AM-05               	Blood               	15 m	N.C.	N.C.	N.C.

AM-05               	Blood               	30 m	11.1877 g	11.4057 g 0.2180 g

AM-05               	Blood               	1 h	N.C.	N.C.	N.C.

AM-05               	Blood               	2 h	11.3557 g	11.5411 g	0.1854 g

AM-05               	Blood               	4 h	N.C.	N.C.	N.C.

AM-05               	Blood               	6 h	11.1845 g	11.2590 g	0.0745 g

AM-05               	Blood               	6.25 h	N.C.	N.C.	N.C.

AM-05               	Blood               	6.50 h	11.2168 g	11.3994 g 0.1826 g

AM-05               	Blood               	7 h	N.C.	N.C.	N.C.

AM-05               	Blood               	7.33 h	11.3649 g	11.5585 g 0.1936 g

AM-05               	Blood               	8 h	N.C.	N.C.	N.C.

AM-05               	Blood               	10 h	11.2248 g	11.4093 g 0.1845 g

AM-05               	Blood               	16 h	N.C.	N.C.	N.C.

AM-05               	Blood               	24 h	11.4001 g	11.5802 g 0.1801 g

AM-06               	Blood               	Predose	11.3955 g	11.5799 g 0.1844 g

AM-06               	Blood               	5 m	N.C.	N.C.	N.C.

AM-06               	Blood               	10 m	11.3726 g	11.6361 g 0.2635 g

AM-06               	Blood               	10 m	11.3726 g	11.6361 g 0.2635 g

AM-06               	Blood               	15 m	N.C.	N.C.	N.C.

AM-06               	Blood               	30 m	11.3646 g	11.5919 g 0.2273 g

AM-06               	Blood               	1 h	N.C.	N.C.	N.C.

AM-06               	Blood               	2 h	11.1996 g	11.3722 g	0.1726 g

AM-06               	Blood               	4 h	N.C.	N.C.	N.C.

AM-06               	Blood               	6 h	11.3379 g	11.5769 g	0.2390 g

AM-06               	Blood               	6.25 h	N.C.	N.C.	N.C.

AM-06               	Blood               	6.50 h	11.1831 g	11.3885 g 0.2054 g

AM-06               	Blood               	7 h	N.C.	N.C.	N.C.

AM-06               	Blood               	7.33 h	11.2140 g	11.3992 g 0.1852 g

AM-06               	Blood               	8 h	N.C.	N.C.	N.C.

AM-06               	Blood               	10 h	11.1886 g	11.3758 g 0.1872 g

AM-06               	Blood               	16 h	N.C.	N.C.	N.C.

AM-06               	Blood               	24 h	11.2312 g	11.4147 g 0.1835 g

Table 2 (contd).  Blood Sample Weights from Group A.

Subject	Sample	Time	Pot wt	Sample  wt	Corrected

Sample Weight

AF-01               	Blood               	Predose	11.1291 g	11.3771 g 0.2480 g

AF-01               	Blood               	5 m	11.3310 g	11.5398 g	0.2088 g

AF-01               	Blood               	10 m	N.C.	N.C.	N.C.

AF-01               	Blood               	15 m	11.1447 g	11.3298 g 0.1851 g

AF-01               	Blood               	30 m	N.C.	N.C.	N.C.

AF-01               	Blood               	1 h	11.2324 g	11.4361 g	0.2037 g

AF-01               	Blood               	2 h	N.C.	N.C.	N.C.

AF-01               	Blood               	4 h	11.1913 g	11.3916 g	0.2003 g

AF-01               	Blood               	6 h	N.C.	N.C.	N.C.

AF-01               	Blood               	6.25 h	11.1559 g	11.3721 g 0.2162 g

AF-01               	Blood               	6.50 h	N.C.	N.C.	N.C.

AF-01               	Blood               	7 h	11.3248 g	11.5011 g	0.1763 g

AF-01               	Blood               	7.33 h	N.C.	N.C.	N.C.

AF-01               	Blood               	8 h	11.2111 g	11.3844 g	0.1733 g

AF-01               	Blood               	10 h	N.C.	N.C.	N.C.

AF-01               	Blood               	16 h	11.2184 g	11.4104 g 0.1920 g

AF-01               	Blood               	24 h	N.C.	N.C.	N.C.

AF-02               	Blood               	Predose	11.3486 g	11.5351 g 0.1865 g

AF-02               	Blood               	5 m	11.1955 g	11.4358 g	0.2403 g

AF-02               	Blood               	10 m	N.C.	N.C.	N.C.

AF-02               	Blood               	15 m	11.3651 g	11.5766 g 0.2115 g

AF-02               	Blood               	30 m	N.C.	N.C.	N.C.

AF-02               	Blood               	1 h	11.2009 g	11.4147 g	0.2138 g

AF-02               	Blood               	2 h	N.C.	N.C.	N.C.

AF-02               	Blood               	4 h	11.1653 g	11.3543 g	0.1890 g

AF-02               	Blood               	6 h	N.C.	N.C.	N.C.

AF-02               	Blood               	6.25 h	11.3460 g	11.5281 g 0.1821 g

AF-02               	Blood               	6.50 h	N.C.	N.C.	N.C.

AF-02               	Blood               	7 h	11.4304 g	11.6057 g	0.1753 g

AF-02               	Blood               	7.33 h	N.C.	N.C.	N.C.

AF-02               	Blood               	8 h	11.4004 g	11.5626 g	0.1622 g

AF-02               	Blood               	10 h	N.C.	N.C.	N.C.

AF-02               	Blood               	16 h	11.2027 g	11.3560 g 0.1533 g

AF-02               	Blood               	24 h	N.C.	N.C.	N.C.

Table 2 (contd).  Blood Sample Weights from Group A.

Subject	Sample	Time	Pot wt	Sample  wt	Corrected

Sample Weight

AF-03               	Blood               	Predose	11.2306 g	11.3887 g 0.1581 g

AF-03               	Blood               	5 m	11.1761 g	11.3002 g	0.1241 g

AF-03               	Blood               	10 m	N.C.	N.C.	N.C.

AF-03               	Blood               	15 m	11.2173 g	11.3713 g 0.1540 g

AF-03               	Blood               	30 m	N.C.	N.C.	N.C.

AF-03               	Blood               	1 h	11.1616 g	11.3718 g	0.2102 g

AF-03               	Blood               	2 h	N.C.	N.C.	N.C.

AF-03               	Blood               	4 h	11.2198 g	11.4459 g	0.2261 g

AF-03               	Blood               	6 h	N.C.	N.C.	N.C.

AF-03               	Blood               	6.25 h	11.2496 g	11.4027 g 0.1531 g

AF-03               	Blood               	6.50 h	N.C.	N.C.	N.C.

AF-03               	Blood               	7 h	11.2221 g	11.3962 g	0.1741 g

AF-03               	Blood               	7.33 h	N.C.	N.C.	N.C.

AF-03               	Blood               	8 h	11.2496 g	11.4627 g	0.2131 g

AF-03               	Blood               	10 h	N.C.	N.C.	N.C.

AF-03               	Blood               	16 h	11.2962 g	11.4679 g 0.1717 g

AF-03               	Blood               	24 h	N.C.	N.C.	N.C.

AF-04               	Blood               	Predose	11.2236 g	11.4068 g 0.1832 g

AF-04               	Blood               	5 m	N.C.	N.C.	N.C.

AF-04               	Blood               	10 m	11.3813 g	11.5701 g 0.1888 g

AF-04               	Blood               	15 m	N.C.	N.C.	N.C.

AF-04               	Blood               	30 m	11.1526 g	11.3641 g 0.2115 g

AF-04               	Blood               	1 h	N.C.	N.C.	N.C.

AF-04               	Blood               	2 h	11.1605 g	11.3137 g	0.1532 g

AF-04               	Blood               	4 h	N.C.	N.C.	N.C.

AF-04               	Blood               	6 h	11.2091 g	11.3934 g	0.1843 g

AF-04               	Blood               	6.25 h	N.C.	N.C.	N.C.

AF-04               	Blood               	6.50 h	11.3755 g	11.5460 g 0.1705 g

AF-04               	Blood               	7 h	N.C.	N.C.	N.C.

AF-04               	Blood               	7.33 h	11.3771 g	11.5487 g 0.1716 g

AF-04               	Blood               	8 h	N.C.	N.C.	N.C.

AF-04               	Blood               	10 h	11.2255 g	11.3967 g 0.1712 g

AF-04               	Blood               	16 h	N.C.	N.C.	N.C.

AF-04               	Blood               	24 h	11.2811 g	11.4613 g 0.1802 g

Table 2 (contd).  Blood Sample Weights from Group A.

Subject	Sample	Time	Pot wt	Sample  wt	Corrected

Sample Weight

AF-05               	Blood               	Predose	11.3193 g	11.4684 g 0.1491 g

AF-05               	Blood               	5 m	N.C.	N.C.	N.C.

AF-05               	Blood               	10 m	11.3289 g	11.5320 g 0.2031 g

AF-05               	Blood               	15 m	N.C.	N.C.	N.C.

AF-05               	Blood               	30 m	11.2137 g	11.3794 g 0.1657 g

AF-05               	Blood               	1 h	N.C.	N.C.	N.C.

AF-05               	Blood               	2 h	11.1775 g	11.3433 g	0.1658 g

AF-05               	Blood               	4 h	N.C.	N.C.	N.C.

AF-05               	Blood               	6 h	11.3272 g	11.5219 g	0.1947 g

AF-05               	Blood               	6.25 h	N.C.	N.C.	N.C.

AF-05               	Blood               	6.50 h	11.3682 g	11.5349 g 0.1667 g

AF-05               	Blood               	7 h	N.C.	N.C.	N.C.

AF-05               	Blood               	7.33 h	11.2059 g	11.3884 g 0.1825 g

AF-05               	Blood               	8 h	N.C.	N.C.	N.C.

AF-05               	Blood               	10 h	11.2451 g	11.4289 g 0.1838 g

AF-05               	Blood               	16 h	N.C.	N.C.	N.C.

AF-05               	Blood               	24 h	11.2257 g	11.4078 g 0.1821 g

AF-06               	Blood               	Predose	11.3616 g	11.5308 g 0.1692 g

AF-06               	Blood               	5 m	N.C.	N.C.	N.C.

AF-06               	Blood               	10 m	11.1749 g	11.3078 g 0.1329 g

AF-06               	Blood               	15 m	N.C.	N.C.	N.C.

AF-06               	Blood               	30 m	11.1923 g	11.4146 g 0.2223 g

AF-06               	Blood               	1 h	N.C.	N.C.	N.C.

AF-06               	Blood               	2 h	11.1812 g	11.3702 g	0.1890 g

AF-06               	Blood               	4 h	N.C.	N.C.	N.C.

AF-06               	Blood               	6 h	11.1287 g	11.3020 g	0.1733 g

AF-06               	Blood               	6.25 h	N.C.	N.C.	N.C.

AF-06               	Blood               	6.50 h	11.1532 g	11.3253 g 0.1721 g

AF-06               	Blood               	7 h	N.C.	N.C.	N.C.

AF-06               	Blood               	7.33 h	11.1741 g	11.4254 g 0.2513 g

AF-06               	Blood               	8 h	N.C.	N.C.	N.C.

AF-06               	Blood               	10 h	11.2900 g	11.4425 g 0.1525 g

AF-06               	Blood               	16 h	N.C.	N.C.	N.C.

AF-06               	Blood               	24 h	11.2421 g	11.4275 g 0.1854 g

Table 3.  Low Concentration Calibration Curve for DIPE in Blood.

 	Peak Area

Sample I.D.	Standard/QC I.D 	 Conc. (ug/ml)	DIPE	MTBE	Peak Area Ratio Cal. Conc. (ug/ml)	Mean	SD	RSD% (Precision)	Accuracy (%)

12322-127A	Blood blank	0	0	0	n/a	n/a	n/a	n/a	n/a	n/a

12322-128A	Blood blank	0	0	0	n/a	n/a	-	-	-	n/a

12322-133A	Blood blank	0	0	0	n/a	n/a	-	-	-	n/a

12322-127B	Blood ISTD blank	0	0	2214393	0	n/a	n/a	n/a	n/a	n/a

12322-128B	Blood ISTD blank	0	0	2158058	0	n/a	-	-	-	n/a

12322-133B	Blood ISTD blank	0	0	2035366	0	n/a	-	-	-	n/a

12322-127C	Std A1 	0.0898	11525	2122933	0.00543	0.0911	0.0908	0.00166 1.83%	101%

12322-128C	Std A1 	0.0898	11854	2153947	0.00550	0.0923	-	-	-	103%

12322-133C	Std A1 	0.0898	10282	1937595	0.00531	0.0890	-	-	-	99.1%

12322-127D	Std B1	0.224	29693	2145488	0.0138	0.231	0.227	0.00412	1.82% 103%

12322-128D	Std B1	0.224	27954	2078860	0.0134	0.225

100%

12322-133D	Std B1	0.224	26653	1991375	0.0134	0.224	 	 	 	100%

12322-127E 	Std A2	0.457	58885	2156926	0.0273	0.456	0.447	0.00909	2.03% 100%

12322-128E 	Std A2	0.457	55824	2083004	0.0268	0.448	-	-	-	98.0%

12322-133E	Std A2	0.457	52944	2019835	0.0262	0.438	-	-	-	95.8%

12322-127F	Std B2	0.910	112752	2083496	0.0541	0.904	0.895	0.00974	1.09% 99.3%

12322-128F	Std B2	0.910	113998	2120200	0.0538	0.898

98.7%

12322-133F	Std B2	0.910	105692	1995024	0.0530	0.88	 	 	 	97.2%

12322-127G	Std A3	2.33	302874	2038370	0.149	2.48	2.38	0.0926	3.90%	106%

12322-128G	Std A3	2.33	279697	1990241	0.141	2.35

101%

12322-133G	Std A3	2.33	275706	1998611	0.138	2.30	 	 	 	98.8%

12322-127H	Std B3	4.61	562576	2000450	0.281	4.69	4.58	0.100	2.19%	102%

12322-128H	Std B3	4.61	581850	2135947	0.272	4.55	-	-	-	98.6%

12322-133H	Std B3	4.61	535866	1986368	0.270	4.50	-	-	-	97.7%

12322-132-13	LQC	0.457	60533	2175613	0.0278	0.465	-	-	-	102%

12322-132-14	LQC	0.457	56369	2125207	0.0265	0.443	-	-	-	97.0%

12322-130-37	MQC	4.61	584614	2141927	0.273	4.56	-	-	-	98.8%

12322-130-38	MQC	4.61	579786	2146326	0.270	4.51	-	-	-	97.8%

	  a   INTERCEPT	-0.000027814

	b     SLOPE	0.059915

	r	0.9996

Table 4.  High Concentration Calibration Curve for DIPE in Blood.

	Peak Area

Sample I.D.	Standard/QC I.D 	 Conc. (ug/ml)	DIPE	MTBE	Peak Area Ratio Cal. Conc. (ug/ml)	Mean	SD	RSD% (Precision)	Accuracy (%)

12322-127H	Std B3	4.61	562576	2000450	0.281	5.04	4.94	0.087	1.76%	109%

12322-128H	Std B3	4.61	581850	2135947	0.272	4.91	-	-	-	107%

12322-133H	Std B3	4.61	535866	1986368	0.270	4.87	-	-	-	106%

12322-127I	Std A4	9.49	1261083	2033960	0.620	9.94	9.71	0.234	2.41%	105%

12322-128I	Std A4	9.49	1252607	2073581	0.604	9.71	-	-	-	102%

12322-133I	Std A4	9.49	1143785	1946173	0.588	9.47	-	-	-	100%

12322-127J	Std B4	23.6	3203037	2025586	1.58	23.8	22.7	1.07	4.70%	101%

12322-128J	Std B4	23.6	3127453	2093341	1.49	22.6	-	-	-	95.7%

12322-133J	Std B4	23.6	2694565	1878234	1.43	21.7	-	-	-	92.0%

12322-127K	Std A5	48.4	6861748	2011540	3.41	50.3	47.0	2.86	6.09%	104%

12322-128K	Std A5	48.4	6413305	2075118	3.09	45.7	-	-	-	94.4%

12322-133K	Std A5	48.4	6075548	1992223	3.05	45.1	-	-	-	93.1%

12322-127L	Std B5	96.8	13281090	1989035	6.68	97.5	91.5	5.27	5.76%	101%

12322-128L	Std B5	96.8	12547672	2068516	6.07	88.7	-	-	-	91.6%

12322-133L	Std B5	96.8	11245967	1865371	6.03	88.2	-	-	-	91.1%

12322-127M	Std A6	247	35964910	1925776	18.7	271	254	17.61	6.93%	110%

12322-128M	Std A6	247	36519922	2072875	17.6	256	-	-	-	103%

12322-133M	Std A6	247	29531463	1817627	16.2	236	-	-	-	95.4%

12322-129-29	HQC	96.8	16459861	2911883	5.65	82.7	-	-	-	85.5%

12322-129-30	HQC	96.8	13359906	2473443	5.40	79.1	-	-	-	81.7%

  a   INTERCEPT	-0.067191

	b     SLOPE	0.069144

	r	0.997

Table 5.  Calibration Curve for Isopropanol in Blood.

 	 	 	Peak Area

Sample I.D.	Standard/QC I.D 	 Conc. (ug/ml)	Isopropanol	1-Propanol	Peak Area Ratio	Cal. Conc. (ug/ml)	Mean	SD	RSD% (Precision)	Accuracy (%)

12322-127H	Std B3	4.31	309729	2070660	0.150	5.21	5.17	0.038	0.73%	120%

12322-128H	Std B3	4.31	302155	2061227	0.147	5.15	-	-	-	-

12322-133H	Std B3	4.31	293968	2007689	0.146	5.15	-	-	-	-

12322-127I	Std A4	9.00	709288	2141030	0.331	9.08	8.98	0.091	1.01%	99.7%

12322-128I	Std A4	9.00	685643	2121227	0.323	8.91	-	-	-	-

12322-133I	Std A4	9.00	632539	1947290	0.325	8.94	-	-	-	-

12322-127J	Std B4	22.1	1808774	2147270	0.842	19.9	20.1	0.151	0.750% 91.1%

12322-128J	Std B4	22.1	1794299	2098258	0.855	20.2	-	-	-	-

12322-133J	Std B4	22.1	1617027	1893249	0.854	20.2	-	-	-	-

12322-127K	Std A5	45.9	4032278	2088233	1.93	43.1	41.6	1.35	3.23%	90.7%

12322-128K	Std A5	45.9	3673564	2032197	1.81	40.5	-	-	-	-

12322-133K	Std A5	45.9	3776924	2047611	1.84	41.3	-	-	-	-

12322-127L	Std B5	90.5	8162809	2120148	3.85	83.9	85.1	1.19	1.40%	94.0%

12322-128L	Std B5	90.5	8307486	2096739	3.96	86.3	-	-	-	-

12322-133L	Std B5	90.5	8181688	2095536	3.90	85	-	-	-	-

12322-126M	Std A6	235	23370217	2076797	11.3	241	245	4.70	1.91%	105%

12322-127M	Std A6	235	22695441	1941824	11.7	251	-	-	-	-

12322-128M	Std A6	235	21694423	1902916	11.4	245	-	-	-	-

12322-130-37	MQC	4.31	314193	2086971	0.151	5.23	-	-	-	121%

12322-130-38	MQC	4.31	333890	2221608	0.150	5.23	-	-	-	121%

12322-129-29	HQC	90.5	9881942	2686808	3.68	80.3	-	-	-	88.7%

12322-129-30	HQC	90.5	8868719	2445017	3.63	79.2	-	-	-	87.5%

  a   INTERCEPT	-0.095588

	b     SLOPE	0.047019

	r	0.997

Table 6.  Calibration Curve for Acetone in Blood.

 	 	 	Peak Area

Sample I.D.	Standard/QC I.D 	 Conc. (ug/ml)	Acetone	1-Propanol	Peak Area Ratio	Cal. Conc. (ug/ml)	Mean	SD	RSD% (Precision)	Accuracy (%)

12322-127G	Std A3	2.21	126646	2033231	0.0623	2.51	2.48	0.0319	1.29%	112%

12322-128G	Std A3	2.21	118493	1949997	0.0608	2.45	-	-	-	-

12322-133G	Std A3	2.21	125349	2049143	0.0612	2.47	-	-	-	-

12322-127H	Std B3	4.30	223600	2070660	0.108	4.36	4.40	0.0353	0.803%	102%

12322-128H	Std B3	4.30	224879	2061227	0.109	4.41	-	-	-	-

12322-133H	Std B3	4.30	220256	2007689	0.110	4.43	-	-	-	-

12322-127I	Std A4	9.02	454345	2141030	0.212	8.57	8.70	0.190	2.19%	96.4%

12322-128I	Std A4	9.02	451733	2121227	0.213	8.60	-	-	-	-

12322-133I	Std A4	9.02	429772	1947290	0.221	8.92	-	-	-	-

12322-127J	Std B4	22.0	1085864	2147270	0.506	20.4	20.9	0.397	1.90%	95.0%

12322-128J	Std B4	22.0	1095322	2098258	0.522	21.1	-	-	-	-

12322-133J	Std B4	22.0	990823	1893249	0.523	21.2	-	-	-	-

12322-127K	Std A5	46.0	2305559	2088233	1.10	44.6	44.0	0.524	1.19%	95.7%

12322-128K	Std A5	46.0	2203661	2032197	1.08	43.8	-	-	-	-

12322-133K	Std A5	46.0	2210602	2047611	1.08	43.6	-	-	-	-

12322-127L	Std B5	90.3	4532539	2120148	2.14	86.4	86.2	2.41	2.80%	95.5%

12322-128L	Std B5	90.3	4591627	2096739	2.19	88.5	-	-	-	-

12322-133L	Std B5	90.3	4339333	2095536	2.07	84	-	-	-	-

12322-126M	Std A6	235	12300203	2076797	5.92	239	242	8.74	3.61%	103%

12322-127M	Std A6	235	12105819	1941824	6.23	252	-	-	-	-

12322-128M	Std A6	235	11073151	1902916	5.82	235	-	-	-	-

12322-130-37	MQC	4.30	221846	2086971	0.106	4.29	-	-	-	100%

12322-130-38	MQC	4.30	241029	2221608	0.108	4.38	-	-	-	102%

12322-129-29	HQC	90.3	5361227	2686808	2.00	80.7	-	-	-	89.3%

12322-129-30	HQC	90.3	4744139	2445017	1.94	78	-	-	-	86.9%

  a   INTERCEPT	0.00013973

	b     SLOPE	0.024733

	r	0.999

Table 7.  DIPE Blood Concentration Analysis for Groups A.

Rat.	Time

point	DIPE

Peak Area	MTBE

Peak Area	Peak Area

Ratio	Cal. Conc.

((g/ml)	Sample

weight (g)	Corrected

Conc.

((g/ml)

AM 01	Predose	0	3305500	0	below LOQ	0.1715	n/a

	5 min	3942626	3094095	1.27	19.4	0.1451	13.4

	15 min	10284961	2726284	3.77	55.5	0.1815	30.6

	1 hr	11169127	2352305	4.75	69.6	0.1883	37.0

	4hr	16109055	2154766	7.48	109	0.1980	55.1

	6.25 hr	6178612	2255680	2.74	40.6	0.1646	24.7

	7 hr	1823281	2073026	0.880	14.7	0.1698	8.65

	8 hr	366955	2163484	0.170	2.83	0.1497	1.89

 	16 hr	3908	1792938	0.00218	below LOQ	0.1602	n/a

AM 02	Predose	0	3220242	0	below LOQ	0.1612	n/a

	5 min	9760022	3004415	3.25	48.0	0.2109	22.7

	15 min	13281846	2657842	5.00	73.2	0.2103	34.8

	1 hr	23604618	2422594	9.74	142	0.3015	47.1

	4hr	13284866	2198086	6.04	88.4	0.1649	53.6

	6.25 hr	3309760	2183125	1.52	22.9	0.1585	14.4

	7 hr	1751996	2074241	0.845	13.2	0.1769	7.45

	8 hr	399385	1912997	0.209	3.48	0.1489	2.34

 	16 hr	18213	1895367	0.00961	below LOQ	0.1800	n/a

AM 03	Predose	0	3125677	0	below LOQ	0.1952	n/a

	5 min	7370270	2937781	2.51	37.3	0.1710	21.8

	15 min	11490102	2682406	4.28	62.9	0.2109	29.8

	1 hr	16872653	2289260	7.37	108	0.2168	49.6

	4hr	17905650	2155261	8.31	121	0.2073	58.4

	6.25 hr	3369772	2182099	1.54	23.3	0.1584	14.7

	7 hr	1731385	2044830	0.847	13.2	0.1740	7.60

	8 hr	534386	2071092	0.258	4.31	0.1798	2.40

 	16 hr	4515	1884535	0.00240	below LOQ	0.1570	n/a

Table 7 (continued).  ETBE DIPE Blood Concentration Analysis for Group A.

Rat.	Time

point	DIPE

Peak Area	MTBE

Peak Area	Peak Area

Ratio	Cal. Conc.

((g/ml)	Sample

weight (g)	Corrected

Conc.

((g/ml)

AM 04	Predose	0	3141737	0	below LOQ	0.1625	n/a

	10 min	6634863	2864181	2.32	34.5	0.1804	19.1

	30 min	7478194	2501719	2.99	44.2	0.1694	26.1

	2 hr	11532703	2276394	5.07	74.2	0.1877	39.6

	6 hr	16647985	2106319	7.90	115	0.2212	52.1

	6.5 hr	3001728	2155520	1.39	21.1	0.1876	11.3

	7.33 hr	1252155	2220162	0.564	9.13	0.1697	5.38

	10 hr	177616	2061463	0.0862	1.44	0.1727	0.833

 	24 hr	0	2006661	0.000	below LOQ	0.1752	n/a

AM 05	Predose	0	3076076	0	below LOQ	0.1819	n/a

	10 min	11508463	2772270	4.15	61.0	0.2252	27.1

	30 min	16985066	2468288	6.88	100	0.2180	46.1

	2 hr	15454012	2326258	6.64	97.1	0.1854	52.3

	6 hr	2817350	2046662	1.38	20.9	0.0745	28.0

	6.5 hr	2061183	2113931	0.975	15.1	0.1826	8.25

	7.33 hr	729460	2040999	0.357	6.14	0.1936	3.17

	10 hr	72643	2018958	0.0360	0.601	0.1845	0.326

 	24 hr	0	1776471	0.000	below LOQ	0.1801	n/a

AM 06	Predose	0	3063913	0	below LOQ	0.1844	n/a

	10 min	14799587	2794446	5.30	77.6	0.2635	29.4

	30 min	16164176	2494808	6.48	94.7	0.2273	41.7

	2 hr	14031744	2189712	6.41	93.6	0.1726	54.3

	6 hr	21078163	2053273	10.3	149	0.2390	62.5

	6.5 hr	3341880	2133667	1.57	23.6	0.2054	11.5

	7.33 hr	653874	2087767	0.313	5.50	0.1852	2.97

	10 hr	76651	1949776	0.0393	0.66	0.1872	0.351

 	24 hr	0	1782700	0.000	below LOQ	0.1835	n/a

Table 7 (continued).  ETBE DIPE Blood Concentration Analysis for Group A.

Rat.	Time

point	DIPE

Peak Area	MTBE

Peak Area	Peak Area

Ratio	Cal. Conc.

((g/ml)	Sample

weight (g)	Corrected

Conc.

((g/ml)

AF 01	Predose	0	3043812	0	below LOQ	0.2480	n/a

	5 min	8818210	2820179	3.13	46.2	0.2088	22.1

	15 min	10416878	2583392	4.03	59.3	0.1851	32.0

	1 hr	14503744	2408498	6.02	88.1	0.2037	43.2

	4hr	16260076	2161490	7.52	110	0.2003	54.8

	6.25 hr	5613786	2137156	2.63	39.0	0.2162	18.0

	7 hr	1173091	2071197	0.566	9.16	0.1763	5.20

	8 hr	404239	1975565	0.205	3.42	0.1733	1.97

 	16 hr	22623	1806051	0.0125	below LOQ	0.1920	n/a

AF 02	Predose	0	3083673	0	below LOQ	0.1865	n/a

	5 min	7871770	2863675	2.75	40.7	0.2403	16.9

	15 min	10413512	2643903	3.94	57.9	0.2115	27.4

	1 hr	18600188	2434213	7.64	111	0.2138	52.1

	4hr	16437024	2112136	7.78	114	0.1890	60.1

	6.25 hr	5113255	2084851	2.45	36.4	0.1821	20.0

	7 hr	1435584	2046806	0.70	11.1	0.1753	6.34

	8 hr	259829	1862016	0.140	2.33	0.1622	1.44

 	16 hr	0	1806061	0.000	below LOQ	0.1533	n/a

AF 03	Predose	0	2976122	0	below LOQ	0.1581	n/a

	5 min	5179417	2901591	1.79	26.8	0.1241	21.6

	15 min	9835262	2659346	3.70	54.5	0.1540	35.4

	1 hr	15868117	2323506	6.83	99.7	0.2102	47.5

	4hr	22848033	2201343	10.4	151	0.2261	66.8

	6.25 hr	3962996	2158089	1.84	27.5	0.1531	18.0

	7 hr	1564184	2064230	0.758	11.9	0.1741	6.85

	8 hr	608280	2167471	0.281	5.03	0.2131	2.36

 	16 hr	3888	1810056	0.00215	below LOQ	0.1717	n/a

 Table 7 (continued).  ETBE DIPE Blood Concentration Analysis for Group A.

Rat.	Time

point	DIPE

Peak Area	MTBE

Peak Area	Peak Area

Ratio	Cal. Conc.

((g/ml)	Sample

weight (g)	Corrected

Conc.

((g/ml)

AF 04	Predose	0	3026192	0	below LOQ	0.1832	n/a

	10 min	8856549	2773431	3.19	47.2	0.1888	25.0

	30 min	15766622	2586291	6.10	89.1	0.2115	42.1

	2 hr	13960100	2236237	6.24	91.3	0.1532	59.6

	6 hr	16325203	2031561	8.04	117	0.1843	63.6

	6.5 hr	2310642	2112871	1.09	16.8	0.1705	9.85

	7.33 hr	757162	2029278	0.373	6.37	0.1716	3.71

	10 hr	82489	2028032	0.0407	0.679	0.1712	0.397

 	24 hr	0	1515234	0.000	below LOQ	0.1802	n/a

AF 05	Predose	0	3050805	0	below LOQ	0.1491	n/a

	10 min	11816192	2789584	4.24	62.2	0.2031	30.6

	30 min	12151980	2539713	4.78	70.2	0.1657	42.3

	2 hr	16836252	2307750	7.30	106	0.1658	64.2

	6 hr	19612248	2042061	9.60	140	0.1947	71.8

	6.5 hr	2553966	2042423	1.25	19.1	0.1667	11.4

	7.33 hr	1033665	1961449	0.527	8.59	0.1825	4.71

	10 hr	90528	2023204	0.0447	0.747	0.1838	0.407

 	24 hr	0	1451432	0.000	below LOQ	0.1821	n/a

AF 06	Predose	0	3018009	0	below LOQ	0.1692	n/a

	10 min	8351910	2776813	3.01	44.5	0.1329	33.5

	30 min	15718575	2481371	6.33	92.6	0.2223	41.6

	2 hr	16424573	2215625	7.41	108	0.1890	57.2

	6 hr	15057861	2065393	7.29	106	0.1733	61.4

	6.5 hr	3573258	2095249	1.71	25.6	0.1721	14.9

	7.33 hr	1543333	2009887	0.768	12.1	0.2513	4.81

	10 hr	65336	2000918	0.0327	0.545	0.1525	0.358

 	24 hr	0	1394642	0.000	below LOQ	0.1854	n/a

Table 8.  Isopropanol Blood Concentration Analysis for Group A.

Rat.	Time

point	Isopropanol

Peak Area	1-Propanol

Peak Area	Peak Area

Ratio	Cal. Conc.

((g/ml)	Sample

weight (g)	Corrected

Conc.

((g/ml)

AM 01	Predose	6272	2153513	0.00291	below LOQ	0.1715	n/a

	5 min	109777	2380795	0.0461	below LOQ	0.1451	n/a

	15 min	351929	1766360	0.199	6.27	0.1815	3.45

	1 hr	1445382	1573428	0.919	21.6	0.1883	11.5

	4hr	5681189	1352656	4.20	91.4	0.1980	46.1

	6.25 hr	8561604	1647935	5.20	113	0.1646	68.4

	7 hr	6432824	1461713	4.40	95.6	0.1698	56.3

	8 hr	3721832	1621117	2.30	50.9	0.1497	34.0

 	16 hr	115326	1437329	0.0802	below LOQ	0.1602	n/a

AM 02	Predose	4018	2146112	0.00187	below LOQ	0.1612	n/a

	5 min	151958	1654781	0.0918	below LOQ	0.2109	n/a

	15 min	310509	1543333	0.201	6.31	0.2103	3.00

	1 hr	1526965	1028884	1.48	33.6	0.3015	11.1

	4hr	4547418	1579939	2.88	63.2	0.1649	38.4

	6.25 hr	7007494	1712280	4.09	89.1	0.1585	56.2

	7 hr	5108536	1450585	3.52	76.9	0.1769	43.5

	8 hr	2980650	1617537	1.84	41.2	0.1489	27.7

 	16 hr	90571	1301098	0.0696	below LOQ	0.1800	n/a

AM 03	Predose	5380	1854237	0.00290	below LOQ	0.1952	n/a

	5 min	175658	1978677	0.0888	below LOQ	0.1710	n/a

	15 min	385625	1495362	0.258	7.52	0.2109	3.56

	1 hr	1541485	1319785	1.17	26.9	0.2168	12.4

	4hr	5138002	1272284	4.04	87.9	0.2073	42.4

	6.25 hr	8226552	1717442	4.79	104	0.1584	65.6

	7 hr	6370190	1501241	4.24	92.3	0.1740	53.0

	8 hr	4429311	1594458	2.78	61.1	0.1798	34.0

 	16 hr	77984	1468074	0.0531	below LOQ	0.1570	n/a

Table 8 (continued).  Isopropanol Blood Concentration Analysis for Group A.

Rat.	Time

point	Isopropanol

Peak Area	1-Propanol

Peak Area	Peak Area

Ratio	Cal. Conc.

((g/ml)	Sample

weight (g)	Corrected

Conc.

((g/ml)

AM 04	Predose	6838	2106071	0.00325	below LOQ	0.1625	n/a

	10 min	215829	1980354	0.109	below LOQ	0.1804	n/a

	30 min	488328	1750458	0.279	7.97	0.1694	4.70

	2 hr	2157660	1492442	1.45	32.8	0.1877	17.5

	6 hr	7972351	1210042	6.59	142	0.2212	64.3

	6.5 hr	6772101	1428055	4.74	103	0.1876	54.8

	7.33 hr	4637067	1579500	2.94	64.5	0.1697	38.0

	10 hr	940207	1529728	0.615	15.1	0.1727	8.75

 	24 hr	3843	1413218	0.00272	below LOQ	0.1752	n/a

AM 05	Predose	3518	1933430	0.00182	below LOQ	0.1819	n/a

	10 min	244913	1511261	0.162	5.48	0.2252	2.43

	30 min	795402	1478297	0.538	13.5	0.2180	6.18

	2 hr	3048080	1479577	2.06	45.8	0.1854	24.7

	6 hr	5527552	2805396	1.97	43.9	0.0745	59.0

	6.5 hr	8254324	1433356	5.76	125	0.1826	68.2

	7.33 hr	5463418	1321156	4.14	90.0	0.1936	46.5

	10 hr	954680	1449282	0.659	16.0	0.1845	8.70

 	24 hr	3161	1314654	0.00240	below LOQ	0.1801	n/a

AM 06	Predose	5676	1923945	0.00295	below LOQ	0.1844	n/a

	10 min	344130	1319405	0.261	7.58	0.2635	2.88

	30 min	836825	1338377	0.625	15.3	0.2273	6.74

	2 hr	2956336	1535211	1.93	43.0	0.1726	24.9

	6 hr	9668514	1155596	8.37	180	0.2390	75.3

	6.5 hr	8433691	1319920	6.39	138	0.2054	67.1

	7.33 hr	5640666	1401146	4.03	87.7	0.1852	47.3

	10 hr	1089471	1404476	0.776	18.5	0.1872	9.90

 	24 hr	3276	1290696	0.00254	below LOQ	0.1835	n/a

Table 8 (continued).  Isopropanol Blood Concentration Analysis for Group A.

Rat.	Time

point	Isopropanol

Peak Area	1-Propanol

Peak Area	Peak Area

Ratio	Cal. Conc.

((g/ml)	Sample

weight (g)	Corrected

Conc.

((g/ml)

AF 01	Predose	4258	1870330	0.00228	below LOQ	0.2480	n/a

	5 min	80094	1646387	0.0486	below LOQ	0.2088	n/a

	15 min	175601	1669197	0.105	below LOQ	0.1851	n/a

	1 hr	537971	1418766	0.379	10.1	0.2037	4.96

	4hr	2139912	1323597	1.62	36.4	0.2003	18.2

	6.25 hr	4187519	1254062	3.34	73.1	0.2162	33.8

	7 hr	2459573	1447194	1.70	38.2	0.1763	21.7

	8 hr	1019824	1430873	0.713	17.2	0.1733	9.92

 	16 hr	7248	1258028	0.00576	below LOQ	0.1920	n/a

AF 02	Predose	4955	1867624	0.00265	below LOQ	0.1865	n/a

	5 min	87060	1462557	0.0595	below LOQ	0.2403	n/a

	15 min	164656	1488895	0.111	below LOQ	0.2115	n/a

	1 hr	508099	1405743	0.361	9.72	0.2138	4.55

	4hr	2124810	1340890	1.58	35.7	0.1890	18.9

	6.25 hr	3773344	1421113	2.66	58.5	0.1821	32.1

	7 hr	2740403	1442899	1.90	42.4	0.1753	24.2

	8 hr	1104185	1535827	0.719	17.3	0.1622	10.7

 	16 hr	0	1518048	0.000	below LOQ	0.1533	n/a

AF 03	Predose	4303	2114181	0.00204	below LOQ	0.1581	n/a

	5 min	60845	2478779	0.0245	below LOQ	0.1241	n/a

	15 min	178917	1929727	0.0927	below LOQ	0.1540	n/a

	1 hr	657330	1339129	0.491	12.5	0.2102	5.93

	4hr	3357579	1194444	2.81	61.8	0.2261	27.3

	6.25 hr	4856392	1691576	2.87	63.1	0.1531	41.2

	7 hr	3566768	1498467	2.38	52.7	0.1741	30.2

	8 hr	1732491	1245271	1.39	31.6	0.2131	14.8

 	16 hr	4547	1376268	0.00330	below LOQ	0.1717	n/a

 Table 8 (continued).  Isopropanol Blood Concentration Analysis for Group A.

Rat.	Time

point	Isopropanol

Peak Area	1-Propanol

Peak Area	Peak Area

Ratio	Cal. Conc.

((g/ml)	Sample

weight (g)	Corrected

Conc.

((g/ml)

AF 04	Predose	3375	1876350	0.00180	below LOQ	0.1832	n/a

	10 min	125400	1738855	0.0721	below LOQ	0.1888	n/a

	30 min	342561	1460313	0.235	7.02	0.2115	3.32

	2 hr	1216382	1711152	0.711	17.2	0.1532	11.2

	6 hr	3624672	1348619	2.69	59.2	0.1843	32.1

	6.5 hr	2949339	1514401	1.95	43.5	0.1705	25.5

	7.33 hr	1503455	1442100	1.04	24.2	0.1716	14.1

	10 hr	192882	1468611	0.131	below LOQ	0.1712	n/a

 	24 hr	0	1176006	0.000	below LOQ	0.1802	n/a

AF 05	Predose	5016	2179453	0.00230	below LOQ	0.1491	n/a

	10 min	124944	1623682	0.0770	below LOQ	0.2031	n/a

	30 min	264987	1780808	0.149	5.20	0.1657	3.14

	2 hr	1128969	1597459	0.707	17.1	0.1658	10.3

	6 hr	3437636	1295821	2.65	58.5	0.1947	30.0

	6.5 hr	2758250	1565204	1.76	39.5	0.1667	23.7

	7.33 hr	1522278	1340694	1.14	26.2	0.1825	14.3

	10 hr	261068	1319854	0.198	6.24	0.1838	3.39

 	24 hr	0	1163884	0.000	below LOQ	0.1821	n/a

AF 06	Predose	5826	2016276	0.00289	below LOQ	0.1692	n/a

	10 min	137916	2246791	0.0614	below LOQ	0.1329	n/a

	30 min	379115	1386373	0.273	7.85	0.2223	3.53

	2 hr	1220027	1416451	0.861	20.4	0.1890	10.8

	6 hr	3606894	1404703	2.57	56.6	0.1733	32.7

	6.5 hr	3314092	1551243	2.14	47.5	0.1721	27.6

	7.33 hr	2032056	1060293	1.92	42.8	0.2513	17.0

	10 hr	281055	1761284	0.160	5.43	0.1525	3.56

 	24 hr	0	1062345	0.000	below LOQ	0.1854	n/a

Table 9.  Acetone Blood Concentration Analysis for Group A.

Rat.	Time

point	Acetone

Peak Area	1-Propanol

Peak Area	Peak Area

Ratio	Cal. Conc.

((g/ml)	Sample

weight (g)	Corrected

Conc.

((g/ml)

AM 01	Predose	270086	2153513	0.125	below LOQ	0.1715	n/a

	5 min	375279	2380795	0.158	6.37	0.1451	4.39

	15 min	1029684	1766360	0.583	23.6	0.1815	13.0

	1 hr	3296086	1573428	2.09	84.7	0.1883	45.0

	4hr	14568860	1352656	10.8	435	0.1980	220

	6.25 hr	21514425	1647935	13.1	528	0.1646	321

	7 hr	20743258	1461713	14.2	574	0.1698	338

	8 hr	19230404	1621117	11.9	480	0.1497	320

 	16 hr	4501539	1437329	3.13	127	0.1602	79.0

AM 02	Predose	180456	2146112	0.0841	3.39	0.1612	2.11

	5 min	549846	1654781	0.332	13.4	0.2109	6.37

	15 min	798701	1543333	0.518	20.9	0.2103	9.95

	1 hr	3979523	1028884	3.87	156	0.3015	51.9

	4hr	12062123	1579939	7.63	309	0.1649	187

	6.25 hr	19050666	1712280	11.1	450	0.1585	284

	7 hr	19021029	1450585	13.1	530	0.1769	300

	8 hr	17189719	1617537	10.6	430	0.1489	289

 	16 hr	3481263	1301098	2.68	108	0.1800	60.1

AM 03	Predose	184997	1854237	0.0998	4.03	0.1952	2.06

	5 min	455526	1978677	0.230	9.30	0.1710	5.44

	15 min	1147140	1495362	0.767	31.0	0.2109	14.7

	1 hr	3857093	1319785	2.92	118	0.2168	54.5

	4hr	13229788	1272284	10.4	420	0.2073	203

	6.25 hr	19661195	1717442	11.4	463	0.1584	292

	7 hr	19369795	1501241	12.9	522	0.1740	300

	8 hr	21034680	1594458	13.2	533	0.1798	297

 	16 hr	3466818	1468074	2.36	95.5	0.1570	60.8

Table 9 (continued).  Acetone Blood Concentration Analysis for Group A.

Rat.	Time

point	Acetone

Peak Area	1-Propanol

Peak Area	Peak Area

Ratio	Cal. Conc.

((g/ml)	Sample

weight (g)	Corrected

Conc.

((g/ml)

AM 04	Predose	151802	2106071	0.0721	2.91	0.1625	1.79

	10 min	681027	1980354	0.344	13.9	0.1804	7.70

	30 min	1652770	1750458	0.944	38.2	0.1694	22.5

	2 hr	6621080	1492442	4.44	179	0.1877	95.6

	6 hr	22100456	1210042	18.3	738	0.2212	334

	6.5 hr	20006287	1428055	14.0	566	0.1876	302

	7.33 hr	19441867	1579500	12.3	498	0.1697	293

	10 hr	14971899	1529728	9.79	396	0.1727	229

 	24 hr	117779	1413218	0.0833	3.36	0.1752	1.92

AM 05	Predose	143411	1933430	0.0742	2.99	0.1819	1.65

	10 min	661144	1511261	0.437	17.7	0.2252	7.85

	30 min	1950469	1478297	1.32	53.3	0.2180	24.5

	2 hr	7122622	1479577	4.81	195	0.1854	105

	6 hr	10322687	2805396	3.68	149	0.0745	200

	6.5 hr	21299372	1433356	14.9	601	0.1826	329

	7.33 hr	20830982	1321156	15.8	637	0.1936	329

	10 hr	15006981	1449282	10.4	419	0.1845	227

 	24 hr	88945	1314654	0.0677	2.73	0.1801	1.52

AM 06	Predose	181028	1923945	0.0941	3.80	0.1844	2.06

	10 min	898106	1319405	0.681	27.5	0.2635	10.4

	30 min	2197824	1338377	1.64	66.4	0.2273	29.2

	2 hr	6285399	1535211	4.09	166	0.1726	95.9

	6 hr	22661455	1155596	19.6	793	0.2390	332

	6.5 hr	21938553	1319920	16.6	672	0.2054	327

	7.33 hr	20723658	1401146	14.8	598	0.1852	323

	10 hr	15227985	1404476	10.8	438	0.1872	234

 	24 hr	88171	1290696	0.0683	2.76	0.1835	1.50

Table 9 (continued).  Acetone Blood Concentration Analysis for Group A.

Rat.	Time

point	Acetone

Peak Area	1-Propanol

Peak Area	Peak Area

Ratio	Cal. Conc.

((g/ml)	Sample

weight (g)	Corrected

Conc.

((g/ml)

AF 01	Predose<PHONE_NUMBER>02<PHONE_NUMBER>6071	0.07060.0721	2.852.91 0.24800.1625	1.151.79

	5 min<PHONE_NUMBER>27<PHONE_NUMBER>0354	0.1990.344	8.0413.9	0.20880.1804 3.857.70

	15 min<PHONE_NUMBER>770<PHONE_NUMBER>0458	0.3700.944	15.038.2	0.18510.1694 8.0822.5

	1 hr<PHONE_NUMBER>1080<PHONE_NUMBER>2442	1.754.44	70.9179	0.20370.1877 34.895.6

	4hr<PHONE_NUMBER>00456<PHONE_NUMBER>0042	6.7418.3	273738	0.20030.2212	136334

	6.25 hr<PHONE_NUMBER>006287<PHONE_NUMBER>8055	11.414.0	460566	0.21620.1876 213302

	7 hr<PHONE_NUMBER>441867<PHONE_NUMBER>9500	8.3612.3	338498	0.17630.1697 192293

	8 hr<PHONE_NUMBER>971899<PHONE_NUMBER>9728	7.869.79	318396	0.17330.1727 183229

 	16 hr<PHONE_NUMBER>79<PHONE_NUMBER>3218	0.08850.0833	3.573.36	0.19200.1752 1.861.92

AF 02	Predose<PHONE_NUMBER>11<PHONE_NUMBER>3430	0.08820.0742	3.562.99 0.18650.1819	1.911.65

	5 min<PHONE_NUMBER>44<PHONE_NUMBER>1261	0.3880.437	15.717.7	0.24030.2252 6.537.85

	15 min<PHONE_NUMBER>469<PHONE_NUMBER>8297	0.5521.32	22.353.3	0.21150.2180 10.524.5

	1 hr<PHONE_NUMBER>2622<PHONE_NUMBER>9577	1.854.81	74.8195	0.21380.1854 35.0105

	4hr<PHONE_NUMBER>22687<PHONE_NUMBER>5396	6.083.68	246149	0.18900.0745	130200

	6.25 hr<PHONE_NUMBER>299372<PHONE_NUMBER>3356	9.1114.9	368601	0.18210.1826 202329

	7 hr<PHONE_NUMBER>830982<PHONE_NUMBER>1156	8.9115.8	360637	0.17530.1936 205329

	8 hr<PHONE_NUMBER>006981<PHONE_NUMBER>9282	6.8310.4	276419	0.16220.1845 170227

 	16 hr<PHONE_NUMBER>5<PHONE_NUMBER>4654	0.07370.0677	2.972.73	0.15330.1801 1.941.52

AF 03	Predose<PHONE_NUMBER>28<PHONE_NUMBER>3945	0.06960.0941	2.813.80 0.15810.1844	1.782.06

	5 min<PHONE_NUMBER>06<PHONE_NUMBER>9405	0.07860.681	3.1727.5	0.12410.2635 2.5610.4

	15 min<PHONE_NUMBER>824<PHONE_NUMBER>8377	0.2651.64	10.766.4	0.15400.2273 6.9629.2

	1 hr<PHONE_NUMBER>5399<PHONE_NUMBER>5211	1.994.09	80.6166	0.21020.1726 38.395.9

	4hr<PHONE_NUMBER>661455<PHONE_NUMBER>5596	9.8719.6	399793	0.22610.2390	177332

	6.25 hr<PHONE_NUMBER>938553<PHONE_NUMBER>9920	8.2916.6	335672	0.15310.2054 219327

	7 hr<PHONE_NUMBER>723658<PHONE_NUMBER>1146	9.8214.8	397598	0.17410.1852 228323

	8 hr<PHONE_NUMBER>227985<PHONE_NUMBER>4476	13.010.8	524438	0.21310.1872 246234

 	16 hr<PHONE_NUMBER><PHONE_NUMBER>0696	0.05780.0683	below LOQ2.76 0.17170.1835	n/a1.50

 Table 9  (continued). Acetone Blood Concentration Analysis for Group A.

Rat.	Time

point	Acetone

Peak Area	1-Propanol

Peak Area	Peak Area

Ratio	Cal. Conc.

((g/ml)	Sample

weight (g)	Corrected

Conc.

((g/ml)

AF 04	Predose	144203	1876350	0.0769	3.10	0.1832	1.69

	10 min	354288	1738855	0.204	8.23	0.1888	4.36

	30 min	1293392	1460313	0.886	35.8	0.2115	16.9

	2 hr	4690259	1711152	2.74	111	0.1532	72.3

	6 hr	13313353	1348619	9.87	399	0.1843	217

	6.5 hr	12520755	1514401	8.27	334	0.1705	196

	7.33 hr	11564909	1442100	8.02	324	0.1716	189

	10 hr	6852970	1468611	4.67	189	0.1712	110

 	24 hr	60026	1176006	0.0510	below LOQ	0.1802	n/a

AF 05	Predose	116074	2179453	0.0533	below LOQ	0.1491	n/a

	10 min	396178	1623682	0.244	9.86	0.2031	4.85

	30 min	889165	1780808	0.499	20.2	0.1657	12.2

	2 hr	4274073	1597459	2.68	108	0.1658	65.2

	6 hr	12281058	1295821	9.48	383	0.1947	197

	6.5 hr	10953458	1565204	7.00	283	0.1667	170

	7.33 hr	10930515	1340694	8.15	330	0.1825	181

	10 hr	7119040	1319854	5.39	218	0.1838	119

 	24 hr	68095	1163884	0.0585	below LOQ	0.1821	n/a

AF 06	Predose	167418	2016276	0.0830	3.35	0.1692	1.98

	10 min	429890	2246791	0.191	7.73	0.1329	5.82

	30 min	1618253	1386373	1.17	47.2	0.2223	21.2

	2 hr	4960176	1416451	3.50	142	0.1890	74.9

	6 hr	12933193	1404703	9.21	372	0.1733	215

	6.5 hr	13552770	1551243	8.74	353	0.1721	205

	7.33 hr	14730115	1060293	13.9	562	0.2513	224

	10 hr	7809518	1761284	4.43	179	0.1525	118

 	24 hr	132375	1062345	0.125	5.03	0.1854	2.71

Appendix J

Noncompartmental Pharmacokinetic Analysis

Note that this section will be updated with final version

Calculated values from WinNonlin version 1.5 and their units

Rsq

Rsq_adjusted

Corr_XY

No_points_lambda_z

Lambda_z                               1/hr

Lambda_z_lower                           hr

Lambda_z_upper                           hr

HL_Lambda_z                              hr

Tlag                                     hr

Tmax                                     hr

Cmax                                  ug/mL

Cmax_D                          kg*ug/mL/mg

Tlast                                    hr

Clast                                 ug/mL

AUClast                            hr*ug/mL

AUCall                             hr*ug/mL

AUCINF_obs                         hr*ug/mL

AUCINF_D_obs                 hr*kg*ug/mL/mg

AUC_%Extrap_obs                           %

Vz_F_obs                              mL/kg

Cl_F_obs                           mL/hr/kg

AUCINF_pred                        hr*ug/mL

AUCINF_D_pred                hr*kg*ug/mL/mg

AUC_%Extrap_pred                          %

Vz_F_pred                             L/kg

Cl_F_pred                          L/hr/kg

AUMClast                        hr*hr*ug/mL

AUMCINF_obs                     hr*hr*ug/mL

AUMC_%Extrap_obs                          %

AUMCINF_pred                    hr*hr*ug/mL

AUMC_%Extrap_pred                         %

MRTlast                                  hr

MRTINF_obs                               hr

MRTINF_pred                              hr

Kinetics of DIPE in Male and Female Rats exposed to 3600 ppm DIPE by inhalation.

Input File: Data - [A:\DIPEPK~1.XLS]

Sex=Female

Start Time: 20:22:01 07-26-2013

End Time:   20:22:02 07-26-2013

          WINNONLIN NONCOMPARTMENTAL ANALYSIS PROGRAM (V01.5A)

                          Core Version 29Oct97

 Listing of input commands

TITLE 1

DIPE inhalation 3600 ppm

MODEL 200

NVARIABLES 5

NPOINTS 100

XNUMBER 1

YNUMBER 5

DTIME 0

NCONSTANTS 1

CONSTANTS 300

METHOD 2  'Linear trapezoidal

NCATRANS

MISSING 'Missing'

NOBSERVATIONS 14

DATA 'WINNLIN.DAT'

BEGIN

DIPE inhalation 3600 ppm

 WINNONLIN NONCOMPARTMENTAL ANALYSIS PROGRAM

         Noncompartmental Analysis for Extravascular Administration

             Linear Trapezoidal Rule Used to Compute AUC, AUMC

  X             Y          Pred.      Res.       AUC        AUMC      WEIGHT

 ----------------------------------------------------------------------- -----

  .0000         .0000                            .0000      .0000

  .8330E-01     20.22                            .8421      .7015E-01

  .1670         29.69                            2.931      .3482

  .2500         31.60                            5.474      .8818

  .5000         42.05                            14.68      4.497

  1.000         47.61                            37.09      21.66

  2.000         60.34                            91.07      105.8

  4.000         60.56                            212.0      468.7

  6.000         65.61                            338.1      1105.

  6.250         18.67                            348.7      1168.

  6.500         12.06                            352.5      1193.

  7.000     *   6.130      5.693      .4370      357.1      1223.      1.000

  7.330     *   4.409      4.211      .1971      358.8      1236.      1.000

  8.000     *   1.923      2.283     -.3608      360.9      1252.      1.000

  10.00     *   .3870      .3673      .1972E-01  363.2      1271.      1.000

 ----------------------------------------------------------------------- -----

 *) Starred values were included in estimation of Lambda_z.

 @) Note - the concentration at time zero (DTIME) was added for extrapolation purposes

 Dosing_time                        .0000

 Rsq                                .9913

 Rsq(adjusted)                      .9869

 Corr(x:y)                         -.9956

 Tlag                               .0000

 Tmax                              6.0000

 Cmax                             65.6099

 No._points_Lambda_z                4

 Tlast                            10.0000

 Clast                              .3870

 AUClast                         363.2418

 Lambda_z                           .9136

 Lambda_z_lower                    7.0000

 Lambda_z_upper                   10.0000

 t1/2_Lambda_z                      .7587

 AUCall                          363.2418

 AUCINF(observed)                363.6654

 AUCINF(observed)/D                1.2122

 AUC_%Extrap(obs.)                  .1165

 Vz(observed)/F                     .9029

 Cl(observed)/F                     .8249

 AUCINF(predicted)               363.6438

 AUCINF(predicted)/D               1.2121

 AUC_%Extrap(pred.)                 .1106

 Vz(predicted)/F                    .9030

 Cl(predicted)/F                    .8250

 AUMClast                       1270.7918

 AUMCINF(observed)              1275.4915

 AUMC_%Extrap(obs.)                 .3685

 AUMCINF(predicted)             1275.2520

 AUMC_%Extrap(pred.)                .3497

 MRTlast                           3.4985

 MRTINF(observed)                  3.5073

 MRTINF(predicted)                 3.5069

 NORMAL ENDING

Input File: Data - [A:\DIPEPK~1.XLS]

Sex=Male

Start Time: 20:22:02 07-26-2013

End Time:   20:22:03 07-26-2013

          WINNONLIN NONCOMPARTMENTAL ANALYSIS PROGRAM (V01.5A)

                          Core Version 29Oct97

 Listing of input commands

TITLE 1

DIPE inhalation 3600 ppm

MODEL 200

NVARIABLES 5

NPOINTS 100

XNUMBER 1

YNUMBER 5

DTIME 0

NCONSTANTS 1

CONSTANTS 300

METHOD 2  'Linear trapezoidal

NCATRANS

MISSING 'Missing'

NOBSERVATIONS 14

DATA 'WINNLIN.DAT'

BEGIN

DIPE inhalation 3600 ppm

 WINNONLIN NONCOMPARTMENTAL ANALYSIS PROGRAM

         Noncompartmental Analysis for Extravascular Administration

             Linear Trapezoidal Rule Used to Compute AUC, AUMC

  X             Y          Pred.      Res.       AUC        AUMC      WEIGHT

 ----------------------------------------------------------------------- -----

  .0000         .0000                            .0000      .0000

  .8330E-01     19.30                            .8038      .6695E-01

  .1670         25.21                            2.667      .3104

  .2500         31.75                            5.031      .8146

  .5000         37.95                            13.74      4.179

  1.000         44.55                            34.37      20.06

  2.000         48.72                            81.01      91.06

  4.000         55.71                            185.4      411.3

  6.000         47.56                            288.7      919.5

  6.250         17.94                            296.9      969.2

  6.500         10.34                            300.4      991.6

  7.000         7.899                            305.0      1022.

  7.330     *   3.841      3.765      .7544E-01  306.9      1036.      1.000

  8.000     *   2.209      2.268     -.5928E-01  308.9      1051.      1.000

  10.00     *   .5031      .4998      .3333E-02  311.7      1074.      1.000

 ----------------------------------------------------------------------- -----

 *) Starred values were included in estimation of Lambda_z.

 @) Note - the concentration at time zero (DTIME) was added for extrapolation purposes

 Dosing_time                        .0000

 Rsq                                .9995

 Rsq(adjusted)                      .9990

 Corr(x:y)                         -.9997

 Tlag                               .0000

 Tmax                              4.0000

 Cmax                             55.7082

 No._points_Lambda_z                3

 Tlast                            10.0000

 Clast                              .5031

 AUClast                         311.6541

 Lambda_z                           .7563

 Lambda_z_lower                    7.3300

 Lambda_z_upper                   10.0000

 t1/2_Lambda_z                      .9165

 AUCall                          311.6541

 AUCINF(observed)                312.3194

 AUCINF(observed)/D                1.0411

 AUC_%Extrap(obs.)                  .2130

 Vz(observed)/F                    1.2701

 Cl(observed)/F                     .9606

 AUCINF(predicted)               312.3150

 AUCINF(predicted)/D               1.0410

 AUC_%Extrap(pred.)                 .2116

 Vz(predicted)/F                   1.2701

 Cl(predicted)/F                    .9606

 AUMClast                       1074.0417

 AUMCINF(observed)              1081.5742

 AUMC_%Extrap(obs.)                 .6964

 AUMCINF(predicted)             1081.5243

 AUMC_%Extrap(pred.)                .6919

 MRTlast                           3.4463

 MRTINF(observed)                  3.4630

 MRTINF(predicted)                 3.4629

 NORMAL ENDING

Input File: Workbook - [Untitled1]

Sex=Female

                                                  Date:   10/16/2011

                                                  Time:     21:26:08

                  WINNONLIN NONCOMPARTMENTAL ANALYSIS PROGRAM

                        Version 5.3  Build<PHONE_NUMBER>39

                            Core Version 18Sept2006

Settings

--------

Model:  Plasma Data, Extravascular Administration

Number of nonmissing observations:   14

Dose time:      0.00

Dose amount:      300.00

Calculation method:  Linear Trapezoidal with Linear Interpolation

Weighting for lambda_z calculations:  Uniform weighting

Lambda_z method:  Find best fit for lambda_z,  Log regression

Summary Table

-------------

      Time         Conc.      Pred.    Residual      AUC       AUMC      Weight

         hr       ug/mL       ug/mL       ug/mL    hr*ug/mL hr*hr*ug/mL

------------------------------------------------------------------------ -------

     0.0000 @     0.0000                           0.0000     0.0000

    0.08330        20.22                           0.8421    0.07015

     0.1670        29.69                            2.931     0.3482

     0.2500        31.60                            5.474     0.8818

     0.5000        42.05                            14.68      4.497

      1.000        47.61                            37.09      21.66

      2.000        60.34                            91.07      105.8

      4.000        60.56                            212.0      468.7

      6.000        65.61                            338.1      1105.

      6.250        18.67                            348.7      1168.

      6.500        12.06                            352.5      1193.

      7.000 *      6.130      5.693     0.4370      357.1      1223.      1.000

      7.330 *      4.409      4.211     0.1971      358.8      1236.      1.000

      8.000 *      1.923      2.283    -0.3608      360.9      1252.      1.000

      10.00 *     0.3870     0.3673    0.01972      363.2      1271.      1.000

@) Note - the concentration at dose time was added for extrapolation purposes.

*) Starred values were included in the estimation of Lambda_z.

Final Parameters

---------------

Rsq                                                       0.9913

Rsq_adjusted                                              0.9869

Corr_XY                                                  -0.9956

No_points_lambda_z                                        4

Lambda_z                               1/hr               0.9136

Lambda_z_lower                           hr               7.0000

Lambda_z_upper                           hr              10.0000

HL_Lambda_z                              hr               0.7587

Tlag                                     hr               0.0000

Tmax                                     hr               6.0000

Cmax                                  ug/mL              65.6099

Cmax_D                          kg*ug/mL/mg               0.2187

Tlast                                    hr              10.0000

Clast                                 ug/mL               0.3870

AUClast                            hr*ug/mL             363.2418

AUCall                             hr*ug/mL             363.2418

AUCINF_obs                         hr*ug/mL             363.6654

AUCINF_D_obs                 hr*kg*ug/mL/mg               1.2122

AUC_%Extrap_obs                           %               0.1165

Vz_F_obs                              mL/kg             902.9195

Cl_F_obs                           mL/hr/kg             824.9342

AUCINF_pred                        hr*ug/mL             363.6438

AUCINF_D_pred                hr*kg*ug/mL/mg               1.2121

AUC_%Extrap_pred                          %               0.1106

Vz_F_pred                             mL/kg             902.9731

Cl_F_pred                          mL/hr/kg             824.9831

AUMClast                        hr*hr*ug/mL            1270.7918

AUMCINF_obs                     hr*hr*ug/mL            1275.4915

AUMC_%Extrap_obs                          %               0.3685

AUMCINF_pred                    hr*hr*ug/mL            1275.2520

AUMC_%Extrap_pred                         %               0.3497

MRTlast                                  hr               3.4985

MRTINF_obs                               hr               3.5073

MRTINF_pred                              hr               3.5069

Input File: Workbook - [Untitled1]

Sex=Male

                                                  Date:   10/16/2011

                                                  Time:     21:26:08

                  WINNONLIN NONCOMPARTMENTAL ANALYSIS PROGRAM

                        Version 5.3  Build<PHONE_NUMBER>39

                            Core Version 18Sept2006

Settings

--------

Model:  Plasma Data, Extravascular Administration

Number of nonmissing observations:   14

Dose time:      0.00

Dose amount:      300.00

Calculation method:  Linear Trapezoidal with Linear Interpolation

Weighting for lambda_z calculations:  Uniform weighting

Lambda_z method:  Find best fit for lambda_z,  Log regression

Summary Table

-------------

      Time         Conc.      Pred.    Residual      AUC       AUMC      Weight

         hr       ug/mL       ug/mL       ug/mL    hr*ug/mL hr*hr*ug/mL

------------------------------------------------------------------------ -------

     0.0000 @     0.0000                           0.0000     0.0000

    0.08330        19.30                           0.8038    0.06695

     0.1670        25.21                            2.667     0.3104

     0.2500        31.75                            5.031     0.8146

     0.5000        37.95                            13.74      4.179

      1.000        44.55                            34.37      20.06

      2.000        48.72                            81.01      91.06

      4.000        55.71                            185.4      411.3

      6.000        47.56                            288.7      919.5

      6.250        17.94                            296.9      969.2

      6.500        10.34                            300.4      991.6

      7.000        7.899                            305.0      1022.

      7.330 *      3.841      3.765    0.07544      306.9      1036.      1.000

      8.000 *      2.209      2.268   -0.05928      308.9      1051.      1.000

      10.00 *     0.5031     0.4998   0.003333      311.7      1074.      1.000

@) Note - the concentration at dose time was added for extrapolation purposes.

*) Starred values were included in the estimation of Lambda_z.

Final Parameters

---------------

Rsq                                                       0.9995

Rsq_adjusted                                              0.9990

Corr_XY                                                  -0.9997

No_points_lambda_z                                        3

Lambda_z                               1/hr               0.7563

Lambda_z_lower                           hr               7.3300

Lambda_z_upper                           hr              10.0000

HL_Lambda_z                              hr               0.9165

Tlag                                     hr               0.0000

Tmax                                     hr               4.0000

Cmax                                  ug/mL              55.7082

Cmax_D                          kg*ug/mL/mg               0.1857

Tlast                                    hr              10.0000

Clast                                 ug/mL               0.5031

AUClast                            hr*ug/mL             311.6541

AUCall                             hr*ug/mL             311.6541

AUCINF_obs                         hr*ug/mL             312.3194

AUCINF_D_obs                 hr*kg*ug/mL/mg               1.0411

AUC_%Extrap_obs                           %               0.2130

Vz_F_obs                              mL/kg            1270.0912

Cl_F_obs                           mL/hr/kg             960.5552

AUCINF_pred                        hr*ug/mL             312.3150

AUCINF_D_pred                hr*kg*ug/mL/mg               1.0410

AUC_%Extrap_pred                          %               0.2116

Vz_F_pred                             mL/kg            1270.1091

Cl_F_pred                          mL/hr/kg             960.5687

AUMClast                        hr*hr*ug/mL            1074.0417

AUMCINF_obs                     hr*hr*ug/mL            1081.5742

AUMC_%Extrap_obs                          %               0.6964

AUMCINF_pred                    hr*hr*ug/mL            1081.5243

AUMC_%Extrap_pred                         %               0.6919

MRTlast                                  hr               3.4463

MRTINF_obs                               hr               3.4630

MRTINF_pred                              hr               3.4629

Kinetics of Isopropanol in Male and Female Rats exposed to 3600 ppm DIPE by inhalation.

Input File: Data - [A:\DIPEPK~1.XLS]

Sex=Female

Start Time: 20:20:27 07-26-2013

End Time:   20:20:28 07-26-2013

          WINNONLIN NONCOMPARTMENTAL ANALYSIS PROGRAM (V01.5A)

                          Core Version 29Oct97

 Listing of input commands

MODEL 200

NVARIABLES 5

NPOINTS 100

XNUMBER 1

YNUMBER 4

DTIME 0

NCONSTANTS 1

CONSTANTS 300

METHOD 2  'Linear trapezoidal

NCATRANS

MISSING 'Missing'

NOBSERVATIONS 11

DATA 'WINNLIN.DAT'

BEGIN

 WINNONLIN NONCOMPARTMENTAL ANALYSIS PROGRAM

         Noncompartmental Analysis for Extravascular Administration

             Linear Trapezoidal Rule Used to Compute AUC, AUMC

  X             Y          Pred.      Res.       AUC        AUMC      WEIGHT

 ----------------------------------------------------------------------- -----

  .0000         .0000                            .0000      .0000

  .5000         3.329                            .8323      .4162

  1.000         5.146                            2.951      2.119

  2.000         10.75                            10.90      15.44

  4.000         21.48                            43.13      122.9

  6.000         31.61                            96.21      398.4

  6.250         35.71                            104.6      450.0

  6.500         25.59                            112.3      498.7

  7.000         25.37                            125.0      584.7

  7.330     *   15.16      16.02     -.8632      131.7      632.3      1.000

  8.000     *   11.81      10.97      .8418      140.8      701.2      1.000

  10.00     *   3.477      3.542     -.6510E-01  156.0      830.5      1.000

 ----------------------------------------------------------------------- -----

 *) Starred values were included in estimation of Lambda_z.

 @) Note - the concentration at time zero (DTIME) was added for extrapolation purposes

 Dosing_time                        .0000

 Rsq                                .9929

 Rsq(adjusted)                      .9857

 Corr(x:y)                         -.9964

 Tlag                               .0000

 Tmax                              6.2500

 Cmax                             35.7084

 No._points_Lambda_z                3

 Tlast                            10.0000

 Clast                             3.4767

 AUClast                         156.0429

 Lambda_z                           .5653

 Lambda_z_lower                    7.3300