Page 1 of 39 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D. C. 20460 OFFICE OF PREVENTION, PESTICIDES, AND TOXIC SUBSTANCES MEMORANDUM Date: November 23, 2005 Subject: Triadimefon. Acute and Chronic Dietary Exposure Assessments for the Reregistration Eligibility Decision ( RED) Document.

DP Barcode: D314778 PC Code: 109901 40 CFR § : 180.410 Chemical Class: Triazole From: Samuel Ary, Chemist Reregistration Branch II Health Effects Division ( 7509C)

Through: Thurston Morton, Chemist David Soderberg, Chemist Dietary Exposure Science Advisory Council ( DESAC) Health Effects Division ( 7509C)

Alan Nielsen, Branch Senior Scientist Reregistration Branch II Health Effects Division ( 7509C)

To: Richard Griffin, Risk Assessor Reregistration Branch II Health Effects Division ( 7509C)

John Pates, Chemical Review Manager Reregistration Branch I Special Review and Reregistration Division ( 7508C) Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 2 of 39 Executive Summary Acute and chronic dietary ( food and water) exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database ( DEEM FCID   , Version 2.03), which uses food consumption data from the USDA's Continuing Surveys of Food Intakes by Individuals ( CSFII) from 1994 1996 and 1998. The acute and chronic dietary risk assessments were conducted for all supported triadimefon food uses and were performed to support the reregistration eligibility decision document.

Triadimefon, 1( 4 chlorophenoxy) 3,3 dimethyl 1( 1H 1,2,4 triazol 1 yl) 2 butanone is a systemic fungicide used to control rust and mildew on apples, grapes, pears, pineapples, and raspberries. Triadimefon end use products are marketed in the United States under the trade name Bayleton ® and Summit. The reregistration of triadimefon is being supported by Bayer CropScience, the basic producer.

Acute Dietary Exposure Results and Characterization of Input Data A highly refined probabilistic ( Monte Carlo) acute dietary exposure assessment was conducted to estimate the dietary risks associated with the reregistration of triadimefon. The acute dietary exposure assessment incorporated percent crop treated (% CT) estimates provided by the Biological Economic Analysis Division ( BEAD) and DEEM 7.81 default processing factors along with the available data from the processing studies. The anticipated residue ( AR) estimates are based on USDA PDP monitoring data ( PDP data) and field trial data. The assessment also included the 30 year annual peak surface water distribution of concentrations that was generated using the maximum allowable number of applications per year. Acute dietary risk estimates are provided for the general U. S. population and various population subgroups, with the major emphasis placed on the exposure estimates for infants and children. This assessment concludes that for all supported commodities, the acute dietary risk estimates exceed HED's level of concern ( greater than 100% of the aPAD) at the 99.9th exposure percentile for the U. S. population ( 840% of the aPAD) and all population subgroups, with the highest exposed population subgroup being all infants less than one year old at 2400% of the aPAD.

The acute dietary risk estimates for food alone ( no water) exceed HED's level of concern at the 99.9th exposure percentile for children 1 2 years old at 240% of the aPAD, children 3 5 years old at 170%. The acute dietary risk estimate does not exceed HED's level of concern for the U. S. population at 72% of the aPAD.

It is also noted that the acute dietary risk estimates for either surface water concentrations ( no food), 26 applications or 3 applications, exceed HED's level of concern at the 99.9th exposure percentile for the U. S. population and all population subgroups.

For comparison, the estimated surface water distribution of concentrations using a typical number of 3 applications per year was incorporated into the acute dietary exposure assessment. For all supported commodities, the acute dietary risk estimates exceed HED's level of concern at the 99.9th exposure percentile for the U. S. population ( 230% of the aPAD) and all population subgroups, with the highest exposed population subgroup being all infants less than one year old at 710% of the aPAD. Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 3 of 39 The significant acute risk contributors have been identified as water ( direct and indirect, all sources), grape juice, pineapple juice, raisins, and fresh grapes. The estimated drinking water concentrations used in this assessment are calculated using 26 applications per year to turf, which is the maximum number of applications allowed in a single year. This may be overly conservative because Bayer has indicated the typical application rate to be 3 applications per year.

PDP data are available for grapes and pineapples, however, because the monitoring data did not analyze for all triadimefon metabolites of concern, the ratio of total toxic residues ( TTR) to triadimefon from available metabolism studies were used to estimate the total residues of concern. This presented a factor of 70.7x, which would produce AR estimates that are overly conservative. Therefore, grape and pineapple field trial data were incorporated into the assessment. Field trial data and % CT usage data were available for pineapple, however, a high number of detectable residues, the high usage estimate of 100% CT, and high consumption resulted in pineapple being a major acute food risk contributor. Field trial data and % CT usage data were available for grapes, however, a high number of detectable residues and high consumption resulted in grapes being a major acute food risk contributor. The AR estimates are considered moderately refined, although they are considered highly conservative based on the nature of the residue data source since field trial studies use maximum application rates and minimum pre harvest intervals. These estimates may be further refined in the future with additional monitoring data that samples for all residues of concern; however, no additional data are available at this time to further refine the dietary risk estimates to triadimefon.

Chronic Dietary Exposure Results and Characterization of Input Data A highly refined chronic dietary exposure assessment was conducted to estimate the dietary risks associated with the reregistration of triadimefon. The chronic dietary exposure assessment incorporated % CT estimates provided by BEAD and DEEM 7.81 default processing factors along with the available data from the processing studies. The AR estimates are based on PDP data and field trial data. The assessment also included the 1 in 10 year annual mean surface water concentration that was generated using the maximum allowable number of applications per year. Chronic dietary risk estimates are provided for the general U. S. population and various population subgroups, with the major emphasis placed on the exposure estimates for infants and children. This assessment concludes that for all supported commodities, the chronic dietary risk estimates exceed HED's level of concern ( greater than 100% of the cPAD) for all infants less than one year old at 300% of the cPAD, children 1 2 years old at 140% of the cPAD, and children 3 5 years old at 130% of the cPAD. The chronic dietary risk estimate does not exceed HED's level of concern ( less than 100% of the cPAD) for the U. S. population at 91% of the cPAD.

The chronic dietary risk estimates for food alone ( no water) do not exceed HED's level of concern for the U. S. population ( less than 1% of the cPad) and all population subgroups, with the highest exposed population subgroup being children 1 2 years old at 2% of the cPAD.

The chronic dietary risk estimates for the surface water concentration ( no food) that was generated using 26 applications exceed HED's level of concern for all infants less than one year old at 300% of the cPad, children 1 2 years old at 140% of the cPad, and children 3 5 years old at 130% of the cPad. The chronic dietary risk estimate does not exceed HED's level of concern for the U. S. population at 91% of the cPAD. Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 4 of 39 For comparison, the estimated surface water concentration using a typical number of 3 applications per year was incorporated into the chronic dietary exposure assessment. For all supported commodities, the chronic dietary risk estimates do not exceed HED's level of concern for the U. S. population ( 16% of the cPad) and all population subgroups, with the highest exposed population subgroup being all infants less than one year old at 52% of the cPad.

The significant chronic risk contributors have been identified as water ( direct and indirect, all sources). The estimated drinking water concentration used in this assessment was calculated using 26 applications per year to turf, which is the maximum number of applications allowed in a single year. This may be overly conservative because Bayer has indicated the typical application rate to turf to be 3 applications per year.

Aggregate Exposure to Triadimefon and Triadimenol At this time the Agency has decided not to aggregate the exposures resulting from the independent use of triadimefon and triadimenol ( metabolite of triadimefon). This decision not to aggregate was based on the risks associated with the use of triadimefon, as the risk from triadimefon already exceed the Agency's level of concern by itself. Furthermore, the Agency feels that aggregating the metabolite triadimenol exposures from use of triadimefon with the exposures resulting from the use of triadimenol would not allow for the proper evaluation of the use of triadimenol active ingredient products. Should refinements be possible in the future, it may be possible and appropriate to aggregate multiple routes and sources of exposures for these chemicals.

I. Introduction Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose ( i. e., the dose which the Health Effects Division has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose ( PAD). The PAD is equivalent to the Reference Dose ( RfD) divided by the special FQPA Safety Factor.

For acute and non cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References which discuss the acute and chronic dietary risk assessments in more detail are available on the EPA pesticides web site: " Available Information on Assessing Exposure from Pesticides, A User's Guide," 6/ 21/ 2000, web link: http:// www. epa. gov/ fedrgstr/ EPA PEST/ 2000/ July/ Day 12/ 6061. pdf; or see SOP 99.6 ( 8/ 20/ 1999).

II. Residue Information The qualitative nature of triadimefon residues in plants is understood based on the adequate metabolism studies conducted with grapes, cucumbers, tomatoes, and wheat. The Health Effects Division ( HED) Metabolism Assessment Review Committee ( MARC) examined the results of these studies and determined that the residues of concern in plants are triadimefon, triadimenol, KWG 1323, KWG 1342, and, in cereal grains, triadimefon, triadimenol, KWG 1323, KWG 1342, and KWG 1732 ( S. Knizner, HED MARC memorandum, 1/ 3/ 1994). HED has revisited the Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 5 of 39 MARC decision by examining all the available metabolism and field trial data and determined that the triadimefon residues of concern in/ on apples, grapes, pears, pineapples, and raspberries for tolerance expression are triadimefon and triadimenol and for risk assessment are triadimefon, triadimenol, KWG 1323, and KWG 1342.

HED determined that only triadimefon and triadimenol in drinking water should be considered in the dietary risk assessment for reasons indicated in the Drinking Water Data Section below. Triadimefon is not registered for use as a direct livestock treatment. HED concluded that the supported uses on apples, grapes, pears, pineapples, and raspberries results in a 40 CFR § 180.6( a)( 3) situation for livestock commodities; i. e., there is no reasonable expectation of finite residues in livestock commodities. Therefore, tolerances for livestock commodities are not required at the present time ( S. Ary, D314742, 11/ 23/ 2005). Table 1 is a summary of the HED decisions concerning the residues of concern in plants, livestock, and drinking water.

Table 1. Summary of Metabolites and Degradates to be Included in the Risk Assessment and Tolerance Expression for Triadimefon.

Matrix Residues Included in Risk Assessment Residues Included in Tolerance Expression Plants Primary crop  apple, grape, pear, pineapple, and raspberry triadimefon, triadimenol, KWG 1323, and KWG 1342 triadimefon and triadimenol Rotational crop NA = not applicable NA Livestock Ruminant NA NA Poultry NA NA Drinking water triadimefon and triadimenol NA A summary of the triadimefon tolerance reassessment and recommended modifications in commodity definitions is presented in Table 2 ( S. Ary, D314742, 11/ 23/ 2005).

Table 2. Tolerance Reassessment Summary for Triadimefon.

Commodity Current Tolerance ( ppm) Reassessed Tolerance ( ppm) Comment [ Correct Commodity Definition]

Tolerances Established Under 40 CFR § 180.410( a)

Apple 1.0 0.2 New data from field trails show lower residues are expected.

Grape 1.0 1.0 No change.

Pear 1.0 0.2 New data from field trails show lower residues are expected.

Pineapple, fresh 3.0 2.0 Reevaluation of data from field trails show lower residues are expected. [ Pineapple]

Tolerances To Be Proposed Under 40 CFR § 180.410( a)

Grape, raisin None established 2.5 Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Table 2. Tolerance Reassessment Summary for Triadimefon.

Commodity Current Tolerance ( ppm) Reassessed Tolerance ( ppm) Comment [ Correct Commodity Definition]

Page 6 of 39 Tolerances Established Under 40 CFR § 180.410( c)

Raspberry 2.0 2.0 No change.

Residue Data used for Acute and Chronic Dietary Assessments As was stated above the residues included in risk assessment includes three of triadimefon's metabolites, triadimenol, KWG 1323, and KWG 1342. The USDA PDP only analyzed for triadimefon while only sampling for triadimenol in a small number of samples ( 54 samples for pears, 52 samples for pineapples, and no samples for grapes) in grapes, pears, and pineapples; however, in apples, triadimefon and triadimenol were sampled. Since HED concluded that triadimefon, triadimenol, KWG 1323, and KWG 1342 are of concern, residue data for other metabolites besides triadimefon were needed for conducting a dietary risk assessment.

In order to estimate the total residues of triadimefon and all its metabolites, the concentration of triadimefon and all its metabolites of concern ( termed Total Toxic Residue or TTR) were used. The metabolism study conducted with grapes was used based on the similarities to all the supported crops and the fact that it will produce a more conservative assessment than using the cucumber or tomato metabolism studies. To calculate the TRR in PDP monitoring samples, the ratio of the TTR to triadimefon ( TTR: triadimefon) from the grape metabolism study was used for grapes, pears, and pineapples. The ratio of the TTR to triadimefon and triadimenol ( TTR: triadimefon and triadimenol) was used for apples because PDP sampled for triadimefon and triadimenol in apples.

PDP data are available for grapes, pears, and pineapples, however, because the monitoring data analyzed for triadimefon while only sampling for triadimenol in a small number of samples, the ratio of total toxic residues ( TTR) to triadimefon from available metabolism studies were used to estimate the total residues of concern. This presented a factor of 70.7x, which would produce AR estimates that are overly conservative. Therefore, grape and pineapple field trial data were incorporated into the assessment and apple PDP data were translated to pears.

The anticipated residue estimates for apples and pears are based on apple PDP data. As noted above, monitoring data analyzed for triadimefon and triadimenol and not KWG 1323 and KWG 1342, the ratio of TTR to triadimefon and triadimenol from available metabolism studies were used to estimate the total residues of concern.

All triadimefon acute and chronic residue estimates for crop commodities are listed in Attachment 1.

Processing Factors Data from the processing studies were used in this assessment for several commodities along with a DEEM 7.81 default processing factors for dried apple ( 8.0x), dried pear ( 6.25x), and dried pineapple ( 5.0x). Acceptable processing studies are available for apples, grapes, and pineapple. Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 7 of 39 A processing factor of 0.6x was utilized for apple juice and 4.0x for raisin. All other processed commodities showed little or no concentration in the available processing studies. For detailed considerations of processing factors see " Triadimefon. Summary of Analytical Chemistry and Residue Data for the Reregistration Eligibility Decision ( RED) Document" under guideline section 860.1520 ( S. Ary, D314742, 11/ 23/ 2005).

Usage Information Dietary risk estimates are based, in part, on estimates of the percent usage of triadimefon on apples, grapes, pears, pineapples, and raspberries. BEAD has estimated triadimefon use ( J. Carter, SLUA, 6/ 2/ 2005) based on available pesticide survey usage data for the years 1997 to 2003 ( Attachment 17). BEAD estimates are provided to HED as an average and as an estimated maximum. In addition to the SLUA ( Screening Level Usage Analysis) produced by BEAD which provided usage data for apples, grapes, pears, and raspberries; Bayer provided survey data in an email submission to John Pates on 9/ 2/ 2005. Del Monte, Dole, and Maui Pine indicated that 100% of all pineapple seeds are treated and 100% of all fresh pineapples are treated. The estimated maximum % CT was used for the acute dietary risk assessment and the estimated average % CT was used for the chronic dietary risk assessments.

Translation of Residue Data The analyses relied on translating PDP data from apples to pears. The HED Standard Operating Procedure ( SOP) 99.3 was followed during translation of the available apple PDP data to pears. The mode of application, label rates, preharvest intervals, percent crop treated, tolerance levels, and field trial residues are all similar between apples and pears.

Residue Estimates for Individual Crops The following presents residue data, ratios of TTR: triadimefon and triadimefon from metabolism studies, and % CT estimates that were used in the dietary analyses for individual crops.

Apple: PDP data from 2003 were used for apples. A total of 744 samples were analyzed for triadimefon and triadimenol. Triadimefon was not detected in any samples and triadimenol was detected in 14 samples. The ratio of TTR ( 77.8%)/ triadimefon and triadimenol ( 62.3%) = 1.25 from the grape metabolism study was used to estimate the total residues of concern based on reported triadimefon and triadimenol residues in monitoring samples. The estimated maximum % CT for apples of 10% was used for the acute dietary risk assessment and the estimated average % CT of 5% was used for the chronic dietary risk assessments.

Grape: Grape field trial data submitted in MRID 41809401 were used. A total of seven trials were conducted and samples were analyzed for triadimefon, triadimenol, KWG 1323, and KWG 1342. The method LOQ was determined at 0.01 ppm. For values reported below the LOQ, half the LOQ was used in calculating the total combined residues of triadimefon, triadimenol, KWG 1323, and KWG 1342. All residue values were corrected to 1x application rate. The estimated maximum % CT for grapes of 5% was used for the acute dietary risk assessment and the estimated average % CT of 1% was used for the chronic dietary risk assessments. Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 8 of 39 Pear: Apple PDP data were translated to pears. The estimated maximum % CT for pears of 5% was used for the acute dietary risk assessment and the estimated average % CT of 5% was used for the chronic dietary risk assessments.

Pineapple: Pineapple field trial data submitted in MRID 42342307 were used. A total of ten trials were conducted and samples were analyzed for triadimefon, triadimenol, KWG 1323, and KWG 1342. The method LOQ was determined at 0.01 ppm. For values reported below the LOQ, half the LOQ was used in calculating the total combined residues of triadimefon, triadimenol, KWG 1323, and KWG 1342. All residue values were corrected to 1x application rate. The estimated % CT for pineapples of 100% was used for the acute and chronic dietary risk assessments.

Raspberry: No PDP data are available for raspberries, so the available field trial data submitted in MRID 92188061 were used. A total of twelve trials were conducted and samples were analyzed for triadimefon, triadimenol, KWG 1323, and KWG 1342. The method LOQ was determined at 0.01 ppm. For values reported below the LOQ, half the LOQ was used in calculating the total combined residues of triadimefon, triadimenol, KWG 1323, and KWG 1342. All residue values were corrected to 1x application rate. The estimated average % CT for raspberries of 50% was used for the acute and chronic dietary risk assessments.

III. Drinking Water Data The drinking water values used in the dietary risk assessment were provided by the Environmental Fate and Effects Division ( EFED) in the following memorandum: " Tier 2 Drinking Water Assessment for Triadimefon and its Major Degradate Triadimenol" ( J. Angier, D316941, 8/ 31/ 2005). Water residues were incorporated in the DEEM FCID   into the food categories " water, direct, all sources" and " water, indirect, all sources".

The estimated surface drinking water concentrations ( EDWCs) for triadimefon and triadimenol were moderately refined and calculated using PRZM ( Pesticide Root Zone Model) and EXAMS ( Exposure Analysis Modeling System) for use in the human health risk assessment. The estimated groundwater concentrations for triadimefon were unrefined and calculated using SCI GROW ( Screening Concentration In Ground Water), however, were not used in the assessment because residues are shown to be much higher in surface water.

The EDWCs were calculated from the Oregon Christmas tree, Pennsylvania apple, and Florida turf scenarios. The FL turf scenario produced the highest concentrations and is used in this dietary assessment. For the PRZM/ EXAMS model, some initial assumptions/ simplifications were made; 1) total residues ( parent triadimefon plus the degradate triadimenol) are treated as a single component in terms of fate properties ( half lives, etc.), with most of the parent converting to the degradate of concern ( triadimenol) which is generally more persistent in the environment; 2) for total residues, an application depth of 0 cm is assumed to reflect surface applications ( in this case, aerial and ground spray); 3) input parameters most relevant to processes that occur at or near time of application ( molecular weight, vapor pressure, solubility, K oc , and photolysis) are used to reflect the characteristics of the parent alone since the parent is the predominant form available at the surface following application, and these values are nonetheless very close to those for triadimenol; 4) other inputs that are relevant to transport, fate, and persistence of compound ( soil and water half lives) are derived from characteristics of total residues ( parent + triadimenol); 5) Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 9 of 39 the aerobic soil half life for total residues ( triadimefon + triadimenol) was determined to be 240 days and the aerobic aquatic half life for total residues of concern is 480 days; 6) a default Percent Cropped Area ( PCA) factor of 0.87 ( 87%) has been applied to all the scenarios; and 7) other degradates ( e. g., CPMT or chlorophenoxymethyltriazole or 4 chlorophenoxy 1,2,4 triazol 1 ylmethane are not considered here because there is insufficient data on the specific rates and locales of formation and conditions under which formation occurs to evaluate tertiary degradates as part of total triadimefon residues; however, based on current information, other degradates are not at this time considered to be essential components of this drinking water evaluation.

The Florida turf assessment represents an upper bound for potential concentrations since the total number of applications allowed annually is undefined on the label ( assessment is based on the upper bound assumption of 26 applications per year). In addition, the FL turf scenario was also run with a limited number of applications. As requested by Bayer CropScience ( personal communication), a total of three applications per year at the maximum application rate for turf grass ( 3.026 kg/ ha) with 14 day intervals was utilized for a PRZM EXAMS modeling run. This presumably represents a more " typical" use pattern for turf applications. The results of this limited application run are presented here simply as a " what if" scenario for comparison with the same scenario using the maximum potential number of annual applications ( 26). Since there is no information on the label to indicate a limit of three applications per year, results from this scenario should be used strictly as a comparison to the other turf scenario with 26 applications.

There remain some uncertainties that, if addressed, could help predict potential drinking water concerns. Specifically, additional studies elucidating some of the fate parameters would lead to a higher level of confidence in the accuracy of model predictions. These include: aerobic soil metabolism studies, currently there is a single valid study on which the aerobic soil half life for total residues ( triadimefon + triadimenol) is based; aerobic aquatic metabolism studies, of which there are currently none ( 2x the aerobic soil half life is used); and further information on the behavior and characteristics of some of the other degradates, such as CPMT.

Acute Dietary Assessment The 30 year annual peak surface water distribution of concentrations that was generated using the maximum allowable number of applications per year was used for the acute dietary assessment. For comparison, the estimated surface water distribution of concentrations using a typical number of 3 applications per year was incorporated into the acute dietary exposure assessment.

Chronic Dietary Assessment The 1 in 10 year annual mean surface water concentration of 0.1467 ppm was used for the chronic dietary assessment. The surface water concentration was generated using the maximum allowable number of applications per year. For comparison, the estimated surface water concentration of 0.02498 ppm was used in the chronic dietary assessment. The surface water concentration represents a typical number of 3 applications per year. Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 10 of 39 IV. DEEM FCID   Program and Consumption Information Triadimefon acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database ( DEEMFCID   , Version 2.03), which incorporates consumption data from USDA's Continuing Surveys of Food Intakes by Individuals ( CSFII), 1994 1996 and 1998. The 1994 96, 98 data are based on the reported consumption of more than 20,000 individuals over two non consecutive survey days. Foods " as consumed" ( e. g., apple pie) are linked to EPA defined food commodities ( e. g. apples, peeled fruit  cooked; fresh or N/ S; baked; or wheat flour  cooked; fresh or N/ S, baked) using publicly available recipe translation files developed jointly by USDA/ ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U. S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on analysis of the 1994 96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U. S. population, all infants ( less than 1 year old), children 1 2, children 3 5, children 6 12, youth 13 19, adults 20 49, females 13 49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform ( e. g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/ food form to produce a residue intake estimate. The resulting residue intake estimate for each food/ food form is summed with the residue intake estimates for all other food/ food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/ kg body weight/ day and as a percent of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one day food consumption data are used on an individual by individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or " matched" in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user ( i. e., only those who reported eating relevant commodities/ food forms) and a per capita ( i. e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis. However, for tiers 1 and 2, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

V. Toxicological Information A summary of the toxicological doses and endpoints selected for the dietary exposure assessments are provided in Table 3. Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 11 of 39 Table 3. Summary of Toxicological Doses and Endpoints for Triadimefon. 1,2 Exposure Scenario Dose Used in Risk Assessment, UF Special FQPA SF* and Level of Concern for Risk Assessment Study and Toxicological Effects Acute Dietary ( general population) NOAEL = 10 mg/ kg/ day UF = 1000 Acute RfD = 0.01 mg/ kg/ day FQPA SF = 1X aPAD = acute RfD FQPA SF = 0.01 mg/ kg/ day Developmental toxicity in rats. Maternal LOAEL = 25 mg/ kg/ day based on dose related increase in both degree and duration of motor activity.

Developmental NOAEL = 50 mg/ kg/ day. Developmental LOAEL = 100 mg/ kg/ day based on increased incidences of cleft palates; two fetuses from two different litters were found to have cleft palate.

Chronic Dietary ( all populations) NOAEL = 3.4 mg/ kg/ day UF = 1000 Chronic RfD = 0.0034 mg/ kg/ day FQPA SF = 1X cPAD = chronic RfD FQPA SF = 0.0034 mg/ kg/ day Subchronic neurotoxicity study in rats. LOAEL = 54.6/ 68.7 mg/ kg/ day based largely on hyperactivity.

Cancer ( oral, dermal, inhalation) Classification: Category C " possible human carcinogen" based on statistically significant increase in thyroid adenomas in male Wistar rats and statistically significant increases in hepatocellular adenomas in both sexes of the NMRI mouse.

1. Triadimefon. Preliminary Human Health Risk Assessment. PC Code: 109901, DP Barcode: D281838, Case No: 2700, Regulatory Action: Phase 1 Reregistration, Risk Assessment Type: Single Chemical Aggregate. 2. UF = uncertainty factor, FQPA SF = Special FQPA safety factor, NOAEL = no observed adverse effect level, LOAEL = lowest observed adverse effect level, PAD = population adjusted dose ( a = acute, c = chronic) RfD = reference dose, MOE = margin of exposure, LOC = level of concern, NA = Not Applicable.

VI. Results/ Discussion As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM FCID   analyses estimate the dietary exposure of the U. S. population and various population subgroups. The acute dietary exposure analysis results reported in Table 4 are for the general U. S. population, all infants ( less than 1 year old), children 1 2, children 3 5, children 6 12, youth 13 19, adults 20 49, adults 50+ years, and females 13 49. The chronic dietary exposure analysis results reported in Table 5 are for the general U. S. population, all infants ( less than 1 year old), children 1 2, children 3 5, children 6 12, youth 13 19, adults 20 49, adults 50+ years, and females 13 49.

Results of Acute Dietary Exposure Analysis This assessment concludes that for all supported commodities, the acute dietary risk estimates exceed HED's level of concern ( greater than 100% of the aPAD) at the 99.9th exposure percentile for the U. S. population ( 840% of the aPAD) and all population subgroups, with the highest exposed population subgroup being all infants less than one year old at 2400% of the aPAD. The results of the acute dietary exposure analysis at the 95th, 99th, and 99.9th percentiles of exposure Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 12 of 39 are reported in Table 4. The results of the acute dietary exposure analysis at the 99.9th percentile are reported in Table 5 along with chronic dietary exposure analyses for easy comparison.

Table 4. Results of Acute Dietary Exposure Analysis Using DEEM FCID ( Food and Water).

Population Subgroup aPAD ( mg/ kg/ day) 95th Percentile 99th Percentile 99.9th Percentile Exposure ( mg/ kg/ day) % aPAD* Exposure ( mg/ kg/ day) % aPAD* Exposure ( mg/ kg/ day) % aPAD*

General U. S. Population 0.0034 0.006697 200 0.012952 380 0.028541 840 All Infants (< 1 year old) 0.0034 0.024676 730 0.043671 1300 0.080231 2400 Children 1 2 years old 0.0034 0.010562 310 0.019460 570 0.037083 1100 Children 3 5 years old 0.0034 0.009547 280 0.017314 510 0.033309 980 Children 6 12 years old 0.0034 0.006613 190 0.012101 360 0.022809 670 Youth 13 19 years old 0.0034 0.005152 150 0.009947 290 0.021487 630 Adults 20 49 years old 0.0034 0.006224 180 0.011491 340 0.023236 680 Adults 50+ years old 0.0034 0.006004 180 0.010068 300 0.018553 550 Females 13 49 year old 0.0034 0.006285 180 0.011485 340 0.022985 680 The bolded values represent the highest exposed populations for each percentile.

The acute dietary risk estimates for food alone ( no water) exceed HED's level of concern at the 99.9th exposure percentile for children 1 2 years old at 240% of the aPAD, children 3 5 years old at 170%. The acute dietary risk estimate does not exceed HED's level of concern for the U. S. population at 72% of the aPAD. The results of the food alone acute dietary exposure analysis at the 99.9th percentile are reported in Table 7 along with food alone chronic dietary exposure analysis for easy comparison.

For comparison, the estimated surface water distribution of concentrations using a typical number of 3 applications per year was incorporated into the acute dietary exposure assessment. For all supported commodities, the acute dietary risk estimates exceed HED's level of concern at the 99.9th exposure percentile for the U. S. population ( 230% of the aPAD) and all population subgroups, with the highest exposed population subgroup being all infants less than one year old at 710% of the aPAD. The results of the acute dietary exposure analysis at the 99.9th percentile are reported in Table 6 along with chronic dietary exposure analyses for easy comparison.

Results of Chronic Dietary Exposure Analysis This assessment concludes that for all supported commodities, the chronic dietary risk estimates exceed HED's level of concern ( greater than 100% of the cPAD) for all infants less than one year old at 300% of the cPAD, children 1 2 years old at 140% of the cPAD, and children 3 5 years old at 130% of the cPAD. The chronic dietary risk estimate does not exceed HED's level of concern ( less than 100% of the cPAD) for the U. S. population at 91% of the cPAD. The results of the chronic dietary exposure analysis are reported below in Table 5. Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 13 of 39 Table 5. Summary of Dietary Exposure and Risk for Triadimefon ( Food and Water).

Population Subgroup Acute Dietary ( 99.9th Percentile) Chronic Dietary Exposure ( mg/ kg/ day) % aPAD Exposure ( mg/ kg/ day) % cPAD General U. S. Population 0.028541 840 0.003092 93 All Infants (< 1 year old) 0.080231 2400 0.010137 300 Children 1 2 years old 0.037083 1100 0.004592 140 Children 3 5 years old 0.033309 980 0.004299 130 Children 6 12 years old 0.022809 670 0.002965 87 Youth 13 19 years old 0.021487 630 0.002235 66 Adults 20 49 years old 0.023236 680 0.002887 85 Adults 50+ years old 0.018553 550 0.003037 89 Females 13 49 years old 0.022985 680 0.002875 85 The bolded values represent the highest exposed populations for each of the risk assessments.

For comparison, the estimated surface water concentration using a typical number of 3 applications per year was incorporated into the chronic dietary exposure assessment. For all supported commodities, the chronic dietary risk estimates do not exceed HED's level of concern for the U. S. population ( 16% of the cPad) and all population subgroups, with the highest exposed population subgroup being all infants less than one year old at 52% of the cPad. The results of the chronic dietary exposure analysis are reported below in Table 6.

Table 6. Summary of Dietary Exposure and Risk for Triadimefon Using Surface Water that was Calculated with 3 Applications Per Year ( Food and Water).

Population Subgroup Acute Dietary ( 99.9th Percentile) Chronic Dietary Exposure ( mg/ kg/ day) % aPAD Exposure ( mg/ kg/ day) % cPAD General U. S. Population 0.007654 230 0.000542 16 All Infants (< 1 year old) 0.024253 710 0.001755 52 Children 1 2 years old 0.012677 370 0.000845 25 Children 3 5 years old 0.010709 310 0.000779 23 Children 6 12 years old 0.006946 200 0.000529 16 Youth 13 19 years old 0.005649 170 0.000390 12 Adults 20 49 years old 0.006565 190 0.000501 15 Adults 50+ years old 0.005836 170 0.000529 16 Females 13 49 years old 0.006548 190 0.000500 15 The bolded values represent the highest exposed populations for each of the risk assessments. Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 14 of 39 The chronic dietary risk estimates for food alone ( no water) do not exceed HED's level of concern for the U. S. population ( less than 1% of the cPad) and all population subgroups, with the highest exposed population subgroup being children 1 2 years old at 2% of the cPAD. The results of the food alone chronic dietary exposure analysis are reported below in Table 7 along with food alone acute dietary exposure analysis at the 99.9th percentile for easy comparison.

Table 7. Summary of Dietary Exposure and Risk for Triadimefon ( Food Only).

Population Subgroup Acute Dietary ( 99.9th Percentile) Chronic Dietary Exposure ( mg/ kg/ day) % aPAD Exposure ( mg/ kg/ day) % cPAD General U. S. Population 0.002442 72 0.000015 < 1 All Infants (< 1 year old) 0.003239 95 0.000029 1 Children 1 2 years old 0.008249 240 0.000063 2 Children 3 5 years old 0.005862 170 0.000047 1 Children 6 12 years old 0.003064 90 0.000025 1 Youth 13 19 years old 0.001581 47 0.000009 < 1 Adults 20 49 years old 0.001797 53 0.000010 < 1 Adults 50+ years old 0.001831 54 0.000011 < 1 Females 13 49 years old 0.001930 57 0.000011 < 1 The bolded values represent the highest exposed populations for each percentile.

VII. Characterization of Inputs/ Outputs The acute and chronic dietary exposure assessments were refined through the use of experimentally determined processing factors, DEEM 7.81 default processing factors, and percent crop treated estimates provided by BEAD. The anticipated residue estimates are based on USDA PDP monitoring data and field trial data. However, because monitoring data did not analyze for all triadimefon metabolites of concern, the ratio of total toxic residues ( TTR) to triadimefon from available metabolism studies were used to estimate the total residues of concern. The metabolism study conducted with grapes was used based on the similarities to all the supported crops and the fact that it will produce a more conservative assessment than using the cucumber or tomato metabolism studies. HED concludes that the exposure estimates provided in this document are unlikely to underestimate actual exposure.

VIII. Conclusions Acute and chronic dietary ( food and water) exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database ( DEEM FCID   , Version 2.03), which uses food consumption data from the USDA's Continuing Surveys of Food Intakes by Individuals ( CSFII) from 1994 1996 and 1998. The acute and chronic dietary risk assessments were conducted for all supported triadimefon food uses and were performed to support the reregistration eligibility decision document. Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 15 of 39 This assessment concludes that for all supported commodities, the acute dietary risk estimates exceed HED's level of concern ( greater than 100% of the aPAD) at the 99.9th exposure percentile for the U. S. population ( 840% of the aPAD) and all population subgroups, with the highest exposed population subgroup being all infants less than one year old at 2400% of the aPAD. The significant acute risk contributors have been identified as water ( direct and indirect, all sources), grape juice, pineapple juice, raisins, and fresh grapes.

This assessment concludes that for all supported commodities, the chronic dietary risk estimates exceed HED's level of concern ( greater than 100% of the cPAD) for all infants less than one year old at 300% of the cPAD, children 1 2 years old at 140% of the cPAD, and children 3 5 years old at 130% of the cPAD. The chronic dietary risk estimate does not exceed HED's level of concern ( less than 100% of the cPAD) for the U. S. population at 91% of the cPAD. The significant chronic risk contributors have been identified as water ( direct and indirect, all sources).

The acute and chronic assessments show that dietary exposure and risk are of concern for the supported uses. Refinements may be possible in the future with additional food monitoring data that samples for all residues of concern which may, in turn, lower dietary exposure and risk from food. However, no additional data are available at this time to further refine the dietary risk estimates to triadimefon. Additionally, the estimated drinking water concentrations used in this assessment are calculated using 26 applications per year to turf, which may be overly conservative because Bayer has indicated the typical application rate to be 3 applications per year.

IX. List of Attachments Attachment 1. Data and Residue Estimates Used in Dietary Analyses. Attachment 2. Residue Distribution Files Used for Acute Analyses. Attachment 3. Acute Food and Surface Water Residue Input File. Attachment 4. Acute Food and Surface Water Results File. Attachment 5. Acute Food and Surface Water Critical Exposure Contribution Analysis Attachment 6. Acute Food Only Results File. Attachment 7. Acute Food Only Critical Exposure Contribution Analysis. Attachment 8. Acute Water Only Results File. Attachment 9. Acute Water Only ( 3 Applications Per Year) Results File. Attachment 10. Acute Food and Surface Water ( 3 Applications Per Year) Results File. Attachment 11. Chronic Food and Surface Water Residue Input File. Attachment 12. Chronic Food and Surface Water Results File. Attachment 13. Chronic Food and Surface Water Critical Exposure Contribution Analysis. Attachment 14. Chronic Food Only Results File. Attachment 15. Chronic Water Only Results File. Attachment 16. Chronic Food and Surface Water ( 3 Application Per Year) Results File. Attachment 17. Usage Report in Support of Reregistration for Triadimefon. Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 16 of 39 Attachment 1. Data and Residue Estimates Used in Dietary Analyses.

RAC Classification1 Data Source Years No. of Samples No. of Detectable Residues Avg. LOD ( ppm) % CT Avg. 2 % CT Max. 2 Processing Factors3 Anticipated Residue Estimates/ Tolerance Acute ( Tol., AR,

RDF) 6 Chronic and Cancer ( Tol., AR)

Apple NB or PB PDP ( 1.25x factor) 2003 744 14 0.001 5 10 Juice at 0.6x RDF 1 TOTALZ= 670 TOTALLOD= 60 LODRES= 0.00063 AR ( 0.00010)

Apple B PDP ( 1.25x factor) 2003 744 14 0.001 5 10 Dried at 8x RDF 2 TOTALZ= 0 TOTALLOD= 730 LODRES= 0.00063 AR ( 0.00010)

Grape PB Field trial data ( MRID 41809401) 1991 7 7 0.01 1 5 Raisin at 4x RDF 3 TOTALZ= 140 TOTALLOD= 0 LODRES= 0.005 AR ( 0.0026)

Pear NB of PB Apple PDP data 2003 744 14 0.001 5 5 Dried at 6.25x RDF 4 TOTALZ= 707 TOTALLOD= 23 LODRES= 0.00063 AR ( 0.00010)

Pineapple NB or PB Field trial data ( MRID 42342307) 1992 10 10 0.01 100 100 Dried at 5.0 RDF 5 TOTALZ= 0 TOTALLOD= 0 LODRES= 0.005 AR ( 0.079)

Raspberry PB Field trail data ( MRID 92188061) 1990 12 12 0.01 50 50 None RDF 6 TOTALZ= 12 TOTALLOD= 0 LODRES= 0.005 AR ( 0.51)

Water N/ A EDWCs4 N/ A N/ A N/ A N/ A N/ A N/ A N/ A RDF 7 Surface water distribution Surface water 0.1467 ( 26 apps.)

0.02498 ( 3 apps.)

1. Classification of blended ( B), partially blended ( PB), not blended ( NB).

2. See Chemistry Summary Document under guideline section 860.1520 Processed Food and Feed for details ( S. Ary, D314742, 10/ 28/ 2005).

4. EDWCs = Estimated Drinking Water Concentrations.

5. N/ A = Not applicable.

6. The LOD used in the acute and chronic AR calculations was multiplied by a factor to account for all residues and then divided by 2. For example, the apple acute LODRES was calculated as follows: ( 0.001 x 1.25)/ 2 = 0.00063.

Attachment 2. Residue Distribution Files Used for Acute Analyses. Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 17 of 39 " Apple, B, 10% CT ( 2003 PDP)" TOTALZ= 0 TOTALLOD= 730 LODRES= 0.00063 0.0073 0.0056 7,0.005 0.0038 4,0.0025 " Apple, NB or PB, 10% CT ( 2003 PDP)" TOTALZ= 670 TOTALLOD= 60 LODRES= 0.00063 0.0073 0.0056 7,0.005 0.0038 4,0.0025 " Grape, PB, 5% CT ( Field trial data, MRID 41809401)" TOTALZ= 140 TOTALLOD= 0 LODRES= 0.005 0.22 0.46 0.07 0.03 0.45 0.49 0.12 " Pear, NB or PB, 5% CT ( 2003 Apple PDP data)" TOTALZ= 707 TOTALLOD= 23 LODRES= 0.00063 0.0073 0.0056 7,0.005 0.0038 4,0.0025 Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 18 of 39 " Pineapple, NB or PB, 100% CT ( Field trial data, MRID 42342307)" TOTALZ= 0 TOTALLOD= 0 LODRES= 0.005 0.05 0.08 0.10 0.10 0.11 0.08 0.09 0.06 0.07 0.05 " Raspberry, PB, 50% CT ( Field trail data, MRID 92188061)" TOTALZ= 12 TOTALLOD= 0 LODRES= 0.005 1.59 1.50 1.11 1.26 0.79 0.85 0.77 0.93 0.73 1.65 0.66 0.46 Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 19 of 39 Attachment 3. Acute Food and Surface Water Residue Input File.

U. S. Environmental Protection Agency Ver. 2.02 DEEM FCID Acute analysis for TRIADIMEFON Residue file name: C:\ Pesticides\ Triadimefon\ Dietary\ Acute\ Triadimefon acute. R98 Analysis Date 11 16 2005 Residue file dated: 11 14 2005/ 18: 38: 27/ 8 Reference dose ( aRfD) = 0.0034 mg/ kg bw/ day Comment: Food and Water  RDL indices and parameters for Monte Carlo Analysis: Index Dist Parameter # 1 Param # 2 Param # 3 Comment # Code       1 6 C:\ Pesticides\ Triadimefon\ Dietary\ RDF\ Apple, NB or PB. rdf 2 6 C:\ Pesticides\ Triadimefon\ Dietary\ RDF\ Apple, B. rdf 3 6 C:\ Pesticides\ Triadimefon\ Dietary\ RDF\ Grape, PB. rdf 4 6 C:\ Pesticides\ Triadimefon\ Dietary\ RDF\ Pear, NB or PB. rdf 5 6 C:\ Pesticides\ Triadimefon\ Dietary\ RDF\ Pineapple, NB or PB. rdf 6 6 C:\ Pesticides\ Triadimefon\ Dietary\ RDF\ Raspberry, PB. rdf 7 6 C:\ Pesticides\ Triadimefon\ Dietary\ RDF\ FL Turf Raw Surface Water ( 26 applications). rdf EPA Crop Food Name Def Res Adj. Factors RDL Comment Code Grp ( ppm) # 1 # 2 Pntr          11000070 11 Apple, fruit with peel 0.200000 1.000 1.000 1 11000080 11 Apple, peeled fruit 0.200000 1.000 1.000 1 11000081 11 Apple, peeled fruit babyfood 0.200000 1.000 1.000 1 11000090 11 Apple, dried 0.200000 8.000 1.000 2 11000091 11 Apple, dried babyfood 0.200000 8.000 1.000 2 11000100 11 Apple, juice 0.200000 0.600 1.000 1 11000101 11 Apple, juice babyfood 0.200000 0.600 1.000 1 11000110 11 Apple, sauce 0.200000 1.000 1.000 1 11000111 11 Apple, sauce babyfood 0.200000 1.000 1.000 1 95001750 O Grape 1.000000 1.000 1.000 3 95001760 O Grape, juice 1.000000 1.000 1.000 3 95001761 O Grape, juice babyfood 1.000000 1.000 1.000 3 95001770 O Grape, leaves 1.000000 1.000 1.000 3 95001780 O Grape, raisin 2.500000 4.000 1.000 3 95001790 O Grape, wine and sherry 1.000000 1.000 1.000 3 11002660 11 Pear 0.200000 1.000 1.000 4 11002661 11 Pear babyfood 0.200000 1.000 1.000 4 11002670 11 Pear, dried 0.200000 6.250 1.000 4 11002680 11 Pear, juice 0.200000 1.000 1.000 4 11002681 11 Pear, juice babyfood 0.200000 1.000 1.000 4 95002790 O Pineapple 2.000000 1.000 1.000 5 95002791 O Pineapple babyfood 2.000000 1.000 1.000 5 95002800 O Pineapple, dried 2.000000 5.000 1.000 5 95002810 O Pineapple, juice 2.000000 1.000 1.000 5 95002811 O Pineapple, juice babyfood 2.000000 1.000 1.000 5 13013200 13A Raspberry 2.000000 1.000 1.000 6 13013201 13A Raspberry babyfood 2.000000 1.000 1.000 6 13013210 13A Raspberry, juice 2.000000 1.000 1.000 6 13013211 13A Raspberry, juice babyfood 2.000000 1.000 1.000 6 86010000 O Water, direct, all sources 0.348300 1.000 1.000 7 86020000 O Water, indirect, all sources 0.348300 1.000 1.000 7 Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 20 of 39 Attachment 4. Acute Food and Surface Water Results File.

U. S. Environmental Protection Agency Ver. 2.02 DEEM FCID ACUTE Analysis for TRIADIMEFON ( 1994 98 data) Residue file: Triadimefon acute. R98 Adjustment factor # 2 used. Analysis Date: 11 16 2005/ 17: 48: 58 Residue file dated: 11 14 2005/ 18: 38: 27/ 8 Daily totals for food and foodform consumption used. MC iterations = 1000 MC list in residue file MC seed = 1 Run Comment: " Food and Water" ===============================================================================

Summary calculations ( per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD       U. S. Population: 0.006697 196.98 0.012952 380.94 0.028541 839.43 All infants: 0.024676 725.75 0.043671 1284.45 0.080231 2359.73 Children 1 2 yrs: 0.010562 310.65 0.019460 572.37 0.037083 1090.68 Children 3 5 yrs: 0.009547 280.78 0.017314 509.24 0.033309 979.69 Children 6 12 yrs: 0.006613 194.50 0.012101 355.90 0.022809 670.86 Youth 13 19 yrs: 0.005152 151.53 0.009947 292.55 0.021487 631.97 Adults 20 49 yrs: 0.006224 183.06 0.011491 337.98 0.023236 683.41 Adults 50+ yrs: 0.006004 176.59 0.010068 296.12 0.018553 545.67 Females 13 49 yrs: 0.006285 184.85 0.011485 337.79 0.022985 676.04 Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 21 of 39 Attachment 5. Acute Food and Surface Water Critical Exposure Contribution Analysis.

U. S. Environmental Protection Agency DEEM FCID Acute Critical Exposure Contribution Analysis ( Ver 2.02) CSFII 1994 98 Residue file = C:\ Pesticides\ Triadimefon\ Dietary\ Acute\ Triadimefon acute. R98 Date and time of analysis: 11 16 2005 17: 42: 38 Daily totals for food and foodform consumption used. Adjustment factor # 2 used. Minimum exposure contribution = 1% Monte Carlo Iterations = 1000 Seed = 1 CEC records generated for first 98 iterations. Exposures divided by body weight ================================================================================ U. S. Population Low percentile for CEC records: 99 Exposure ( mg/ day) = 0.012952 High percentile for CEC records: 100 Exposure ( mg/ day) = 0.375864 Number of actual records in this interval: 99679 Critical foods/ foodforms for this population ( as derived from these records): N= number of appearances in all records ( including duplicates) %= percent of total exposure for all records ( including duplicates)

Food FF N Percent Food Name      86020000 130 43062 35.94% Water, indirect, all sources Uncooked; Dried; Cook Meth N/ S 86010000 110 70933 35.76% Water, direct, all sources Uncooked; Fresh or N/ S; Cook Meth N/ S 86020000 240 13350 10.38% Water, indirect, all sources Cooked; Canned; Cook Meth N/ S 86020000 230 16463 6.58% Water, indirect, all sources Cooked; Dried; Cook Meth N/ S 86020000 232 28358 5.82% Water, indirect, all sources Cooked; Dried; Boiled 86020000 110 13517 2.67% Water, indirect, all sources Uncooked; Fresh or N/ S; Cook Meth N/ S 86020000 212 10719 1.00% Water, indirect, all sources Cooked; Fresh or N/ S; Boiled 86020000 120 4588 0.67% Water, indirect, all sources Uncooked; Frozen; Cook Meth N/ S 95001760 110 478 0.27% Grape, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 86020000 210 5464 0.22% Water, indirect, all sources Cooked; Fresh or N/ S; Cook Meth N/ S 95001760 240 382 0.08% Grape, juice Cooked; Canned; Cook Meth N/ S 86020000 215 1631 0.06% Water, indirect, all sources Cooked; Fresh or N/ S; Boiled/ baked 86020000 211 2440 0.06% Water, indirect, all sources Cooked; Fresh or N/ S; Baked 95001780 130 148 0.05% Grape, raisin Uncooked; Dried; Cook Meth N/ S 95002810 110 656 0.05% Pineapple, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 95001761 240 173 0.05% Grape, juice babyfood Cooked; Canned; Cook Meth N/ S 86020000 242 483 0.04% Water, indirect, all sources Cooked; Canned; Boiled 95001750 110 196 0.04% Grape Uncooked; Fresh or N/ S; Cook Meth N/ S 86020000 213 1102 0.03% Water, indirect, all sources Cooked; Fresh or N/ S; Fried 13013200 240 796 0.03% Raspberry Cooked; Canned; Cook Meth N/ S 13013210 110 64 0.03% Raspberry, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 95002810 240 1060 0.02% Pineapple, juice Cooked; Canned; Cook Meth N/ S 95001760 120 21 0.01% Grape, juice Uncooked; Frozen; Cook Meth N/ S 95002811 240 715 0.01% Pineapple, juice babyfood Cooked; Canned; Cook Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 22 of 39 Meth N/ S 13013200 120 29 0.01% Raspberry Uncooked; Frozen; Cook Meth N/ S 95002790 240 333 0.01% Pineapple Cooked; Canned; Cook Meth N/ S 13013201 240 260 0.01% Raspberry babyfood Cooked; Canned; Cook Meth N/ S 13013200 110 166 0.01% Raspberry Uncooked; Fresh or N/ S; Cook Meth N/ S 86020000 233 143 0.00% Water, indirect, all sources Cooked; Dried; Fried 95001780 230 65 0.00% Grape, raisin Cooked; Dried; Cook Meth N/ S 95001790 110 33 0.00% Grape, wine and sherry Uncooked; Fresh or N/ S; Cook Meth N/ S 13013211 240 67 0.00% Raspberry, juice babyfood Cooked; Canned; Cook Meth N/ S 95002790 110 70 0.00% Pineapple Uncooked; Fresh or N/ S; Cook Meth N/ S 13013200 211 31 0.00% Raspberry Cooked; Fresh or N/ S; Baked 95002791 240 81 0.00% Pineapple babyfood Cooked; Canned; Cook Meth N/ S 95002810 120 45 0.00% Pineapple, juice Uncooked; Frozen; Cook Meth N/ S 95001780 211 34 0.00% Grape, raisin Cooked; Fresh or N/ S; Baked 86020000 214 38 0.00% Water, indirect, all sources Cooked; Fresh or N/ S; Fried/ baked 95001750 210 27 0.00% Grape Cooked; Fresh or N/ S; Cook Meth N/ S 95002790 211 43 0.00% Pineapple Cooked; Fresh or N/ S; Baked 95001780 210 9 0.00% Grape, raisin Cooked; Fresh or N/ S; Cook Meth N/ S 95001750 240 19 0.00% Grape Cooked; Canned; Cook Meth N/ S 95001760 210 16 0.00% Grape, juice Cooked; Fresh or N/ S; Cook Meth N/ S 13013210 240 11 0.00% Raspberry, juice Cooked; Canned; Cook Meth N/ S 11000101 240 4 0.00% Apple, juice babyfood Cooked; Canned; Cook Meth N/ S 95002790 210 5 0.00% Pineapple Cooked; Fresh or N/ S; Cook Meth N/ S 86020000 223 3 0.00% Water, indirect, all sources Cooked; Frozen; Fried 95001790 210 2 0.00% Grape, wine and sherry Cooked; Fresh or N/ S; Cook Meth N/ S 11000111 240 2 0.00% Apple, sauce babyfood Cooked; Canned; Cook Meth N/ S 95001780 212 1 0.00% Grape, raisin Cooked; Fresh or N/ S; Boiled 11000100 110 2 0.00% Apple, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 11000100 240 1 0.00% Apple, juice Cooked; Canned; Cook Meth N/ S 95001790 213 1 0.00% Grape, wine and sherry Cooked; Fresh or N/ S; Fried 11000070 110 1 0.00% Apple, fruit with peel Uncooked; Fresh or N/ S; Cook Meth N/ S ================================================================================ All infants Low percentile for CEC records: 99 Exposure ( mg/ day) = 0.043671 High percentile for CEC records: 100 Exposure ( mg/ day) = 0.375864 Number of actual records in this interval: 2813 Critical foods/ foodforms for this population ( as derived from these records): N= number of appearances in all records ( including duplicates) %= percent of total exposure for all records ( including duplicates)

Food FF N Percent Food Name      86020000 130 2053 64.67% Water, indirect, all sources Uncooked; Dried; Cook Meth N/ S 86010000 110 1697 12.41% Water, direct, all sources Uncooked; Fresh or N/ S; Cook Meth N/ S 86020000 240 443 10.87% Water, indirect, all sources Cooked; Canned; Cook Meth N/ S 86020000 230 337 8.76% Water, indirect, all sources Cooked; Dried; Cook Meth N/ S 86020000 110 383 2.67% Water, indirect, all sources Uncooked; Fresh or N/ S; Cook Meth N/ S 86020000 232 79 0.18% Water, indirect, all sources Cooked; Dried; Boiled 86020000 212 78 0.17% Water, indirect, all sources Cooked; Fresh or N/ S; Boiled Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 23 of 39 95001761 240 7 0.10% Grape, juice babyfood Cooked; Canned; Cook Meth N/ S 86020000 120 20 0.09% Water, indirect, all sources Uncooked; Frozen; Cook Meth N/ S 86020000 242 7 0.02% Water, indirect, all sources Cooked; Canned; Boiled 95002810 110 12 0.02% Pineapple, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 86020000 210 8 0.01% Water, indirect, all sources Cooked; Fresh or N/ S; Cook Meth N/ S 86020000 215 6 0.01% Water, indirect, all sources Cooked; Fresh or N/ S; Boiled/ baked 95001760 110 1 0.00% Grape, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 86020000 211 8 0.00% Water, indirect, all sources Cooked; Fresh or N/ S; Baked 95001760 240 1 0.00% Grape, juice Cooked; Canned; Cook Meth N/ S 86020000 213 3 0.00% Water, indirect, all sources Cooked; Fresh or N/ S; Fried 95001780 230 1 0.00% Grape, raisin Cooked; Dried; Cook Meth N/ S 95002810 240 1 0.00% Pineapple, juice Cooked; Canned; Cook Meth N/ S 95002811 240 1 0.00% Pineapple, juice babyfood Cooked; Canned; Cook Meth N/ S Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 24 of 39 Attachment 6. Acute Food Only Results File.

U. S. Environmental Protection Agency Ver. 2.02 DEEM FCID ACUTE Analysis for TRIADIMEFON ( 1994 98 data) Residue file: Triadimefon acute ( food only). R98 Adjustment factor # 2 used. Analysis Date: 11 16 2005/ 18: 08: 46 Residue file dated: 11 14 2005/ 17: 51: 21/ 8 Daily totals for food and foodform consumption used. MC iterations = 1000 MC list in residue file MC seed = 1 Run Comment: " Food Only" ===============================================================================

Summary calculations ( per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD       U. S. Population: 0.000068 1.99 0.000422 12.42 0.002442 71.82 All infants: 0.000179 5.26 0.000707 20.80 0.003239 95.25 Children 1 2 yrs: 0.000387 11.38 0.001734 50.99 0.008249 242.61 Children 3 5 yrs: 0.000270 7.94 0.001174 34.52 0.005862 172.41 Children 6 12 yrs: 0.000133 3.92 0.000600 17.64 0.003064 90.13 Youth 13 19 yrs: 0.000025 0.74 0.000272 8.01 0.001581 46.50 Adults 20 49 yrs: 0.000038 1.11 0.000269 7.92 0.001797 52.87 Adults 50+ yrs: 0.000058 1.69 0.000296 8.69 0.001831 53.85 Females 13 49 yrs: 0.000039 1.16 0.000288 8.47 0.001930 56.76 Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 25 of 39 Attachment 7. Acute Food Only Critical Exposure Contribution Analysis.

U. S. Environmental Protection Agency DEEM FCID Acute Critical Exposure Contribution Analysis ( Ver 2.02) CSFII 1994 98 Residue file = C:\ Pesticides\ Triadimefon\ Dietary\ Acute\ Triadimefon acute ( food only). R98 Date and time of analysis: 11 16 2005 18: 03: 57 Daily totals for food and foodform consumption used. Adjustment factor # 2 used. Minimum exposure contribution = 1% Monte Carlo Iterations = 1000 Seed = 1 CEC records generated for first 97 iterations. Exposures divided by body weight ================================================================================ U. S. Population Low percentile for CEC records: 99 Exposure ( mg/ day) = 0.000422 High percentile for CEC records: 100 Exposure ( mg/ day) = 0.057738 Number of actual records in this interval: 75173 Critical foods/ foodforms for this population ( as derived from these records): N= number of appearances in all records ( including duplicates) %= percent of total exposure for all records ( including duplicates)

Food FF N Percent Food Name      95002810 110 16953 15.51% Pineapple, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 95001760 110 4211 15.13% Grape, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 95001760 240 6980 11.24% Grape, juice Cooked; Canned; Cook Meth N/ S 13013200 240 12783 10.35% Raspberry Cooked; Canned; Cook Meth N/ S 95001750 110 4725 7.71% Grape Uncooked; Fresh or N/ S; Cook Meth N/ S 95002810 240 17659 5.85% Pineapple, juice Cooked; Canned; Cook Meth N/ S 95001780 130 2278 5.62% Grape, raisin Uncooked; Dried; Cook Meth N/ S 95002790 240 10324 5.19% Pineapple Cooked; Canned; Cook Meth N/ S 13013200 110 4304 4.15% Raspberry Uncooked; Fresh or N/ S; Cook Meth N/ S 13013210 110 1322 3.63% Raspberry, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 95001790 110 2359 3.32% Grape, wine and sherry Uncooked; Fresh or N/ S; Cook Meth N/ S 13013200 120 1013 1.81% Raspberry Uncooked; Frozen; Cook Meth N/ S 95001761 240 706 1.80% Grape, juice babyfood Cooked; Canned; Cook Meth N/ S 13013201 240 1601 0.97% Raspberry babyfood Cooked; Canned; Cook Meth N/ S 95002810 120 1601 0.94% Pineapple, juice Uncooked; Frozen; Cook Meth N/ S 95002811 240 2871 0.94% Pineapple, juice babyfood Cooked; Canned; Cook Meth N/ S 95001780 230 1257 0.85% Grape, raisin Cooked; Dried; Cook Meth N/ S 95002790 110 1750 0.73% Pineapple Uncooked; Fresh or N/ S; Cook Meth N/ S 95001780 211 1100 0.72% Grape, raisin Cooked; Fresh or N/ S; Baked 95001760 120 194 0.72% Grape, juice Uncooked; Frozen; Cook Meth N/ S 13013200 211 1212 0.48% Raspberry Cooked; Fresh or N/ S; Baked 13013210 120 380 0.46% Raspberry, juice Uncooked; Frozen; Cook Meth N/ S 13013211 240 525 0.30% Raspberry, juice babyfood Cooked; Canned; Cook Meth N/ S 95001780 210 343 0.29% Grape, raisin Cooked; Fresh or N/ S; Cook Meth N/ S Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 26 of 39 13013210 240 963 0.26% Raspberry, juice Cooked; Canned; Cook Meth N/ S 95001750 210 509 0.23% Grape Cooked; Fresh or N/ S; Cook Meth N/ S 95002791 240 1289 0.18% Pineapple babyfood Cooked; Canned; Cook Meth N/ S 95001750 240 900 0.16% Grape Cooked; Canned; Cook Meth N/ S 95001760 210 382 0.14% Grape, juice Cooked; Fresh or N/ S; Cook Meth N/ S 95001780 232 51 0.07% Grape, raisin Cooked; Dried; Boiled 95002800 130 163 0.05% Pineapple, dried Uncooked; Dried; Cook Meth N/ S 95002790 211 215 0.04% Pineapple Cooked; Fresh or N/ S; Baked 95002790 210 301 0.02% Pineapple Cooked; Fresh or N/ S; Cook Meth N/ S 95001790 210 46 0.01% Grape, wine and sherry Cooked; Fresh or N/ S; Cook Meth N/ S 11000100 240 540 0.01% Apple, juice Cooked; Canned; Cook Meth N/ S 11000100 110 370 0.01% Apple, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 95001770 211 13 0.01% Grape, leaves Cooked; Fresh or N/ S; Baked 95001780 213 7 0.01% Grape, raisin Cooked; Fresh or N/ S; Fried 11000070 110 312 0.01% Apple, fruit with peel Uncooked; Fresh or N/ S; Cook Meth N/ S 95001780 212 14 0.01% Grape, raisin Cooked; Fresh or N/ S; Boiled 11000110 212 121 0.00% Apple, sauce Cooked; Fresh or N/ S; Boiled 95001780 110 5 0.00% Grape, raisin Uncooked; Fresh or N/ S; Cook Meth N/ S 11000111 240 113 0.00% Apple, sauce babyfood Cooked; Canned; Cook Meth N/ S 11000101 240 87 0.00% Apple, juice babyfood Cooked; Canned; Cook Meth N/ S 95001790 212 4 0.00% Grape, wine and sherry Cooked; Fresh or N/ S; Boiled 11002681 240 30 0.00% Pear, juice babyfood Cooked; Canned; Cook Meth N/ S 11002660 240 62 0.00% Pear Cooked; Canned; Cook Meth N/ S 95001790 240 5 0.00% Grape, wine and sherry Cooked; Canned; Cook Meth N/ S 95002810 211 51 0.00% Pineapple, juice Cooked; Fresh or N/ S; Baked 11000081 240 70 0.00% Apple, peeled fruit babyfood Cooked; Canned; Cook Meth N/ S 95001790 213 5 0.00% Grape, wine and sherry Cooked; Fresh or N/ S; Fried 11002660 110 25 0.00% Pear Uncooked; Fresh or N/ S; Cook Meth N/ S 95002790 212 37 0.00% Pineapple Cooked; Fresh or N/ S; Boiled 95001770 210 2 0.00% Grape, leaves Cooked; Fresh or N/ S; Cook Meth N/ S 11000100 120 5 0.00% Apple, juice Uncooked; Frozen; Cook Meth N/ S 95001790 221 3 0.00% Grape, wine and sherry Cooked; Frozen; Baked 11002661 240 22 0.00% Pear babyfood Cooked; Canned; Cook Meth N/ S 95002810 212 37 0.00% Pineapple, juice Cooked; Fresh or N/ S; Boiled 95001780 240 5 0.00% Grape, raisin Cooked; Canned; Cook Meth N/ S 95001750 120 4 0.00% Grape Uncooked; Frozen; Cook Meth N/ S 11002680 240 9 0.00% Pear, juice Cooked; Canned; Cook Meth N/ S 11002660 210 13 0.00% Pear Cooked; Fresh or N/ S; Cook Meth N/ S 11000110 210 2 0.00% Apple, sauce Cooked; Fresh or N/ S; Cook Meth N/ S 11002670 130 3 0.00% Pear, dried Uncooked; Dried; Cook Meth N/ S 11000090 130 12 0.00% Apple, dried Uncooked; Dried; Cook Meth N/ S 11000080 211 3 0.00% Apple, peeled fruit Cooked; Fresh or N/ S; Baked 11000070 211 3 0.00% Apple, fruit with peel Cooked; Fresh or N/ S; Baked 11002680 110 1 0.00% Pear, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 11000100 210 2 0.00% Apple, juice Cooked; Fresh or N/ S; Cook Meth N/ S 11000090 211 2 0.00% Apple, dried Cooked; Fresh or N/ S; Baked ================================================================================ Children 1 2 yrs Low percentile for CEC records: 99 Exposure ( mg/ day) = 0.001734 High percentile for CEC records: 100 Exposure ( mg/ day) = 0.057738 Number of actual records in this interval: 4158 Critical foods/ foodforms for this population ( as derived from these records): N= number of appearances in all records ( including duplicates) %= percent of total exposure for all records ( including duplicates) Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 27 of 39 Food FF N Percent Food Name      95001760 110 817 32.02% Grape, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 95001760 240 719 15.33% Grape, juice Cooked; Canned; Cook Meth N/ S 95002810 110 990 12.10% Pineapple, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 95001780 130 390 11.33% Grape, raisin Uncooked; Dried; Cook Meth N/ S 95001750 110 500 9.45% Grape Uncooked; Fresh or N/ S; Cook Meth N/ S 13013210 110 140 5.08% Raspberry, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 13013200 240 322 3.23% Raspberry Cooked; Canned; Cook Meth N/ S 95002810 240 1134 2.32% Pineapple, juice Cooked; Canned; Cook Meth N/ S 13013200 110 179 2.19% Raspberry Uncooked; Fresh or N/ S; Cook Meth N/ S 95001761 240 68 2.11% Grape, juice babyfood Cooked; Canned; Cook Meth N/ S 95002790 240 399 1.95% Pineapple Cooked; Canned; Cook Meth N/ S 95001760 120 44 1.80% Grape, juice Uncooked; Frozen; Cook Meth N/ S 13013211 240 30 0.22% Raspberry, juice babyfood Cooked; Canned; Cook Meth N/ S 95001780 230 27 0.20% Grape, raisin Cooked; Dried; Cook Meth N/ S 95001780 210 27 0.19% Grape, raisin Cooked; Fresh or N/ S; Cook Meth N/ S 95001780 211 25 0.17% Grape, raisin Cooked; Fresh or N/ S; Baked 95002811 240 43 0.08% Pineapple, juice babyfood Cooked; Canned; Cook Meth N/ S 95002790 110 53 0.06% Pineapple Uncooked; Fresh or N/ S; Cook Meth N/ S 95001750 240 22 0.05% Grape Cooked; Canned; Cook Meth N/ S 13013200 211 26 0.02% Raspberry Cooked; Fresh or N/ S; Baked 95001780 232 2 0.01% Grape, raisin Cooked; Dried; Boiled 95002810 120 8 0.01% Pineapple, juice Uncooked; Frozen; Cook Meth N/ S 13013201 240 7 0.01% Raspberry babyfood Cooked; Canned; Cook Meth N/ S 95002790 211 9 0.01% Pineapple Cooked; Fresh or N/ S; Baked 95001750 210 4 0.01% Grape Cooked; Fresh or N/ S; Cook Meth N/ S 95001760 210 6 0.01% Grape, juice Cooked; Fresh or N/ S; Cook Meth N/ S 13013200 120 13 0.00% Raspberry Uncooked; Frozen; Cook Meth N/ S 95002790 210 16 0.00% Pineapple Cooked; Fresh or N/ S; Cook Meth N/ S 11000100 110 6 0.00% Apple, juice Uncooked; Fresh or N/ S; Cook Meth N/ S 11000100 120 2 0.00% Apple, juice Uncooked; Frozen; Cook Meth N/ S 95002800 130 2 0.00% Pineapple, dried Uncooked; Dried; Cook Meth N/ S 13013210 120 4 0.00% Raspberry, juice Uncooked; Frozen; Cook Meth N/ S 11002681 240 4 0.00% Pear, juice babyfood Cooked; Canned; Cook Meth N/ S 11000110 212 3 0.00% Apple, sauce Cooked; Fresh or N/ S; Boiled 11000101 240 2 0.00% Apple, juice babyfood Cooked; Canned; Cook Meth N/ S 13013210 240 3 0.00% Raspberry, juice Cooked; Canned; Cook Meth N/ S 11000100 240 3 0.00% Apple, juice Cooked; Canned; Cook Meth N/ S 11002660 110 2 0.00% Pear Uncooked; Fresh or N/ S; Cook Meth N/ S 11000070 110 2 0.00% Apple, fruit with peel Uncooked; Fresh or N/ S; Cook Meth N/ S 95002791 240 1 0.00% Pineapple babyfood Cooked; Canned; Cook Meth N/ S 11002660 240 1 0.00% Pear Cooked; Canned; Cook Meth N/ S Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 28 of 39 Attachment 8. Acute Water Only Results File.

U. S. Environmental Protection Agency Ver. 2.02 DEEM FCID ACUTE Analysis for TRIADIMEFON ( 1994 98 data) Residue file: Triadimefon acute ( water only). R98 Adjustment factor # 2 used. Analysis Date: 11 14 2005/ 19: 21: 24 Residue file dated: 11 14 2005/ 17: 52: 02/ 8 Daily totals for food and foodform consumption used. MC iterations = 1000 MC list in residue file MC seed = 1 Run Comment: " Water Only" ===============================================================================

Summary calculations ( per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD       U. S. Population: 0.006657 195.78 0.012883 378.90 0.028500 838.24 All infants: 0.024712 726.82 0.043759 1287.04 0.080379 2364.10 Children 1 2 yrs: 0.010362 304.77 0.019156 563.42 0.036609 1076.72 Children 3 5 yrs: 0.009429 277.34 0.017136 504.01 0.033071 972.67 Children 6 12 yrs: 0.006557 192.86 0.011995 352.80 0.022416 659.29 Youth 13 19 yrs: 0.005139 151.16 0.009903 291.27 0.021279 625.85 Adults 20 49 yrs: 0.006201 182.38 0.011468 337.31 0.023409 688.50 Adults 50+ yrs: 0.005984 176.01 0.010054 295.71 0.018441 542.39 Females 13 49 yrs: 0.006262 184.18 0.011438 336.40 0.022996 676.35 Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 29 of 39 Attachment 9. Acute Water Only ( 3 Applications Per Year) Results File.

U. S. Environmental Protection Agency Ver. 2.02 DEEM FCID ACUTE Analysis for TRIADIMEFON ( 1994 98 data) Residue file: Triadimefon acute ( 3 applications water only). R98 Adjustment factor # 2 used. Analysis Date: 11 14 2005/ 19: 28: 20 Residue file dated: 11 14 2005/ 17: 54: 12/ 8 Daily totals for food and foodform consumption used. MC iterations = 1000 MC list in residue file MC seed = 1 Run Comment: " Water Only" ===============================================================================

Summary calculations ( per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD       U. S. Population: 0.001153 33.91 0.002816 82.82 0.007339 215.85 All infants: 0.004167 122.56 0.010143 298.33 0.024312 715.07 Children 1 2 yrs: 0.001761 51.80 0.004320 127.05 0.010711 315.03 Children 3 5 yrs: 0.001631 47.98 0.003923 115.38 0.009479 278.80 Children 6 12 yrs: 0.001125 33.10 0.002722 80.05 0.006580 193.53 Youth 13 19 yrs: 0.000854 25.11 0.002162 63.60 0.005535 162.81 Adults 20 49 yrs: 0.001083 31.84 0.002591 76.20 0.006458 189.95 Adults 50+ yrs: 0.001118 32.88 0.002491 73.25 0.005694 167.48 Females 13 49 yrs: 0.001085 31.90 0.002600 76.47 0.006428 189.05 Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 30 of 39 Attachment 10. Acute Food and Surface Water ( 3 Applications Per Year) Results File.

U. S. Environmental Protection Agency Ver. 2.02 DEEM FCID ACUTE Analysis for TRIADIMEFON ( 1994 98 data) Residue file: Triadimefon acute ( 3 applications). R98 Adjustment factor # 2 used. Analysis Date: 11 16 2005/ 18: 01: 42 Residue file dated: 11 14 2005/ 17: 54: 59/ 8 Daily totals for food and foodform consumption used. MC iterations = 1000 MC list in residue file MC seed = 1 Run Comment: " Food and Water" ===============================================================================

Summary calculations ( per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD       U. S. Population: 0.001222 35.94 0.002965 87.19 0.007654 225.13 All infants: 0.004245 124.85 0.010248 301.43 0.024253 713.31 Children 1 2 yrs: 0.002058 60.53 0.005060 148.81 0.012677 372.84 Children 3 5 yrs: 0.001841 54.14 0.004419 129.97 0.010709 314.97 Children 6 12 yrs: 0.001224 35.99 0.002935 86.33 0.006946 204.29 Youth 13 19 yrs: 0.000891 26.21 0.002224 65.40 0.005649 166.15 Adults 20 49 yrs: 0.001128 33.17 0.002685 78.96 0.006565 193.08 Adults 50+ yrs: 0.001168 34.35 0.002585 76.03 0.005836 171.66 Females 13 49 yrs: 0.001134 33.37 0.002706 79.59 0.006548 192.60 Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 31 of 39 Attachment 11. Chronic Food and Surface Water Residue Input File.

U. S. Environmental Protection Agency Ver. 2.00 DEEM FCID Chronic analysis for TRIADIMEFON 1994 98 data Residue file: C:\ Pesticides\ Triadimefon\ Dietary\ Chronic\ Triadimefon chronic. R98 Adjust. # 2 used Analysis Date 11 16 2005 Residue file dated: 11 16 2005/ 17: 35: 08/ 8 Reference dose ( RfD) = 0.0034 mg/ kg bw/ day Comment: Food and Water  Food Crop Residue Adj. Factors Comment EPA Code Grp Food Name ( ppm) # 1 # 2         11000070 11 Apple, fruit with peel 0.000100 1.000 1.000 11000080 11 Apple, peeled fruit 0.000100 1.000 1.000 11000081 11 Apple, peeled fruit babyfood 0.000100 1.000 1.000 11000090 11 Apple, dried 0.000100 8.000 1.000 11000091 11 Apple, dried babyfood 0.000100 8.000 1.000 11000100 11 Apple, juice 0.000100 0.600 1.000 11000101 11 Apple, juice babyfood 0.000100 0.600 1.000 11000110 11 Apple, sauce 0.000100 1.000 1.000 11000111 11 Apple, sauce babyfood 0.000100 1.000 1.000 95001750 O Grape 0.002600 1.000 1.000 95001760 O Grape, juice 0.002600 1.000 1.000 95001761 O Grape, juice babyfood 0.002600 1.000 1.000 95001770 O Grape, leaves 0.002600 1.000 1.000 95001780 O Grape, raisin 0.002600 4.000 1.000 95001790 O Grape, wine and sherry 0.002600 1.000 1.000 11002660 11 Pear 0.000100 1.000 1.000 11002661 11 Pear babyfood 0.000100 1.000 1.000 11002670 11 Pear, dried 0.000100 6.250 1.000 11002680 11 Pear, juice 0.000100 1.000 1.000 11002681 11 Pear, juice babyfood 0.000100 1.000 1.000 95002790 O Pineapple 0.079000 1.000 1.000 95002791 O Pineapple babyfood 0.079000 1.000 1.000 95002800 O Pineapple, dried 0.079000 5.000 1.000 95002810 O Pineapple, juice 0.079000 1.000 1.000 95002811 O Pineapple, juice babyfood 0.079000 1.000 1.000 13013200 13A Raspberry 0.510000 1.000 1.000 13013201 13A Raspberry babyfood 0.510000 1.000 1.000 13013210 13A Raspberry, juice 0.510000 1.000 1.000 13013211 13A Raspberry, juice babyfood 0.510000 1.000 1.000 86010000 O Water, direct, all sources 0.146700 1.000 1.000 86020000 O Water, indirect, all sources 0.146700 1.000 1.000 Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 32 of 39 Attachment 12. Chronic Food and Surface Water Results File.

U. S. Environmental Protection Agency Ver. 2.00 DEEM FCID Chronic analysis for TRIADIMEFON ( 1994 98 data) Residue file name: C:\ Pesticides\ Triadimefon\ Dietary\ Chronic\ Triadimefon chronic. R98 Adjustment factor # 2 used. Analysis Date 11 16 2005/ 17: 37: 10 Residue file dated: 11 16 2005/ 17: 35: 08/ 8 Reference dose ( RfD, Chronic) = .0034 mg/ kg bw/ day COMMENT 1: Food and Water =============================================================================== Total exposure by population subgroup

Total Exposure  Population mg/ kg Percent of Subgroup body wt/ day Rfd    U. S. Population ( total) 0.003107 91.4%

U. S. Population ( spring season) 0.003079 90.6% U. S. Population ( summer season) 0.003339 98.2% U. S. Population ( autumn season) 0.003003 88.3% U. S. Population ( winter season) 0.003004 88.4%

Northeast region 0.002835 83.4% Midwest region 0.003141 92.4% Southern region 0.002951 86.8% Western region 0.003564 104.8%

Hispanics 0.003525 103.7% Non hispanic whites 0.003033 89.2% Non hispanic blacks 0.002947 86.7% Non hisp/ non white/ non black 0.003804 111.9%

All infants (< 1 year) 0.010166 299.0% Nursing infants 0.003776 111.1% Non nursing infants 0.012591 370.3% Children 1 6 yrs 0.004369 128.5% Children 7 12 yrs 0.002832 83.3%

Females 13 19 ( not preg or nursing) 0.002183 64.2% Females 20+ ( not preg or nursing) 0.003098 91.1% Females 13 50 yrs 0.003003 88.3% Females 13+ ( preg/ not nursing) 0.003019 88.8% Females 13+ ( nursing) 0.004306 126.6%

Males 13 19 yrs 0.002286 67.2% Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 33 of 39 Males 20+ yrs 0.002780 81.8% Seniors 55+ 0.003046 89.6%

Children 1 2 yrs 0.004655 136.9% Children 3 5 yrs 0.004345 127.8% Children 6 12 yrs 0.002990 87.9% Youth 13 19 yrs 0.002244 66.0% Adults 20 49 yrs 0.002897 85.2% Adults 50+ yrs 0.003049 89.7% Females 13 49 yrs 0.002886 84.9%

Attachment 13. Chronic Food and Surface Water Critical Exposure Contribution Analysis.

U. S. Environmental Protection Agency Ver. 2.00 DEEM FCID Chronic analysis for TRIADIMEFON ( 1994 98 data) Residue file name: C:\ Pesticides\ Triadimefon\ Dietary\ Chronic\ Triadimefon chronic. R98 Adjustment factor # 2 used. Analysis Date 11 16 2005/ 17: 38: 47 Residue file dated: 11 16 2005/ 17: 35: 08/ 8 Reference dose ( RfD, Chronic) = .0034 mg/ kg bw/ day COMMENT 1: Food and Water =============================================================================== Critical Commodity Contribution Analysis for All infants (< 1 year)

Total Exposure =. 0101664 mg/ kg bw/ day Crop groups with total exposure contribution > 99% Foods/ Foodforms with exposure contribution > .1%

Crop group  Exposure Analysis Food mg/ kg % of Total Percent Foodform body wt/ day Exposure of RfD

Crop Group = ( O) Other Water, direct, all sources ( 86010000): FoodForm N/ S 0.0013507 13.29% 39.73% Water, indirect, all sources ( 86020000): FoodForm N/ S 0.0087867 86.43% 258.43%     Total for crop group 0.0101585 99.92% 298.78%

Total for crop groups listed above: 0.0101585 99.92% 298.8% Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 34 of 39 Attachment 14. Chronic Food Only Results File.

U. S. Environmental Protection Agency Ver. 2.00 DEEM FCID Chronic analysis for TRIADIMEFON ( 1994 98 data) Residue file name: C:\ Pesticides\ Triadimefon\ Dietary\ Chronic\ Triadimefon chronic ( food only). R98 Adjustment factor # 2 used. Analysis Date 11 16 2005/ 17: 39: 58 Residue file dated: 11 16 2005/ 17: 35: 59/ 8 Reference dose ( RfD, Chronic) = .0034 mg/ kg bw/ day COMMENT 1: Food Only =============================================================================== Total exposure by population subgroup

Total Exposure  Population mg/ kg Percent of Subgroup body wt/ day Rfd    U. S. Population ( total) 0.000015 0.4%

U. S. Population ( spring season) 0.000014 0.4% U. S. Population ( summer season) 0.000017 0.5% U. S. Population ( autumn season) 0.000014 0.4% U. S. Population ( winter season) 0.000015 0.4%

Northeast region 0.000015 0.4% Midwest region 0.000015 0.4% Southern region 0.000012 0.4% Western region 0.000021 0.6%

Hispanics 0.000015 0.5% Non hispanic whites 0.000016 0.5% Non hispanic blacks 0.000012 0.4% Non hisp/ non white/ non black 0.000013 0.4%

All infants (< 1 year) 0.000029 0.9% Nursing infants 0.000016 0.5% Non nursing infants 0.000034 1.0% Children 1 6 yrs 0.000050 1.5% Children 7 12 yrs 0.000023 0.7%

Females 13 19 ( not preg or nursing) 0.000007 0.2% Females 20+ ( not preg or nursing) 0.000011 0.3% Females 13 50 yrs 0.000012 0.3% Females 13+ ( preg/ not nursing) 0.000012 0.4% Females 13+ ( nursing) 0.000022 0.6% Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 35 of 39 Males 13 19 yrs 0.000011 0.3% Males 20+ yrs 0.000009 0.3% Seniors 55+ 0.000010 0.3%

Children 1 2 yrs 0.000063 1.8% Children 3 5 yrs 0.000047 1.4% Children 6 12 yrs 0.000025 0.7% Youth 13 19 yrs 0.000009 0.3% Adults 20 49 yrs 0.000010 0.3% Adults 50+ yrs 0.000011 0.3% Females 13 49 yrs 0.000011 0.3%

Attachment 15. Chronic Water Only Results File.

U. S. Environmental Protection Agency Ver. 2.00 DEEM FCID Chronic analysis for TRIADIMEFON ( 1994 98 data) Residue file name: C:\ Pesticides\ Triadimefon\ Dietary\ Chronic\ Triadimefon chronic ( water only). R98 Adjustment factor # 2 used. Analysis Date 11 15 2005/ 11: 45: 42 Residue file dated: 09 12 2005/ 20: 20: 40/ 8 Reference dose ( RfD, Chronic) = 0.0034 mg/ kg bw/ day COMMENT 1: Water Only =============================================================================== Total exposure by population subgroup

Total Exposure  Population mg/ kg Percent of Subgroup body wt/ day Rfd    U. S. Population ( total) 0.003092 90.9%

U. S. Population ( spring season) 0.003065 90.1% U. S. Population ( summer season) 0.003321 97.7% U. S. Population ( autumn season) 0.002989 87.9% U. S. Population ( winter season) 0.002989 87.9%

Northeast region 0.002821 83.0% Midwest region 0.003126 91.9% Southern region 0.002939 86.4% Western region 0.003543 104.2%

Hispanics 0.003510 103.2% Non hispanic whites 0.003017 88.7% Non hispanic blacks 0.002935 86.3% Non hisp/ non white/ non black 0.003791 111.5%

All infants (< 1 year) 0.010137 298.2% Nursing infants 0.003760 110.6% Non nursing infants 0.012557 369.3% Children 1 6 yrs 0.004320 127.1% Children 7 12 yrs 0.002809 82.6%

Females 13 19 ( not preg or nursing) 0.002176 64.0% Females 20+ ( not preg or nursing) 0.003086 90.8% Females 13 50 yrs 0.002991 88.0% Females 13+ ( preg/ not nursing) 0.003007 88.4% Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 36 of 39 Females 13+ ( nursing) 0.004284 126.0%

Males 13 19 yrs 0.002275 66.9% Males 20+ yrs 0.002771 81.5% Seniors 55+ 0.003036 89.3%

Children 1 2 yrs 0.004592 135.0% Children 3 5 yrs 0.004299 126.4% Children 6 12 yrs 0.002965 87.2% Youth 13 19 yrs 0.002235 65.7% Adults 20 49 yrs 0.002887 84.9% Adults 50+ yrs 0.003037 89.3% Females 13 49 yrs 0.002875 84.6%

Attachment 16. Chronic Food and Surface Water ( 3 Applications Per Year) Results File.

U. S. Environmental Protection Agency Ver. 2.00 DEEM FCID Chronic analysis for TRIADIMEFON ( 1994 98 data) Residue file name: C:\ Pesticides\ Triadimefon\ Dietary\ Chronic\ Triadimefon chronic ( 3 applications). R98 Adjustment factor # 2 used. Analysis Date 11 16 2005/ 17: 39: 31 Residue file dated: 11 16 2005/ 17: 36: 41/ 8 Reference dose ( RfD, Chronic) = .0034 mg/ kg bw/ day COMMENT 1: Food and Water =============================================================================== Total exposure by population subgroup

Total Exposure  Population mg/ kg Percent of Subgroup body wt/ day Rfd    U. S. Population ( total) 0.000542 15.9%

U. S. Population ( spring season) 0.000536 15.8% U. S. Population ( summer season) 0.000583 17.1% U. S. Population ( autumn season) 0.000523 15.4% U. S. Population ( winter season) 0.000524 15.4%

Northeast region 0.000495 14.6% Midwest region 0.000548 16.1% Southern region 0.000512 15.1% Western region 0.000624 18.4%

Hispanics 0.000613 18.0% Non hispanic whites 0.000530 15.6% Non hispanic blacks 0.000512 15.1% Non hisp/ non white/ non black 0.000659 19.4%

All infants (< 1 year) 0.001755 51.6% Nursing infants 0.000656 19.3% Non nursing infants 0.002172 63.9% Children 1 6 yrs 0.000785 23.1% Children 7 12 yrs 0.000502 14.8%

Females 13 19 ( not preg or nursing) 0.000378 11.1% Females 20+ ( not preg or nursing) 0.000537 15.8% Females 13 50 yrs 0.000521 15.3% Females 13+ ( preg/ not nursing) 0.000524 15.4% Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 37 of 39 Females 13+ ( nursing) 0.000751 22.1%

Males 13 19 yrs 0.000399 11.7% Males 20+ yrs 0.000481 14.1% Seniors 55+ 0.000527 15.5%

Children 1 2 yrs 0.000845 24.8% Children 3 5 yrs 0.000779 22.9% Children 6 12 yrs 0.000529 15.6% Youth 13 19 yrs 0.000390 11.5% Adults 20 49 yrs 0.000501 14.7% Adults 50+ yrs 0.000529 15.5% Females 13 49 yrs 0.000500 14.7%

Attachment 17. Usage Report in Support of Reregistration for Triadimefon.

Triadimefon ( 109901) Screening Level Usage Analysis ( SLUA) Date: 6/ 2/ 05 What is a Screening Level Usage Analysis ( SLUA)? ° Available estimates of pesticide usage data for a particular active ingredient that is used on agricultural crops in the United States.

What does it contain? ° Pesticide usage data for a single active ingredient only. ° Agricultural use sites ( crops) that the pesticide is reported to be used on. ° Available pesticide usage information ( i. e., does not include all of the United States). ° Annual percent of crop treated ( average & maximum) for each agricultural crop. ° Average annual pounds of the pesticide applied for each agricultural crop ( i. e., for the states surveyed, not for the entire United States).

What assumptions can I make about the reported data? ° Average pounds of active ingredient applied  Values are calculated by merging pesticide usage data sources together; averaging by year, averaging across all years, & then rounding. Note: If the estimated value is less than 500, then that value is labeled < 500. Estimated values between 500 & < 1,000,000 are rounded to 1 significant digit. Estimated values of 1,000,000 or greater are rounded to 2 significant digits.) ° Average percent of crop treated  Values are calculated by merging data sources together; averaging by year, averaging across all years, & rounding to the nearest multiple of 5. Note: If the estimated value is less than 1, then the value is labeled < 1. ° Maximum percent of crop treated  Value is the single maximum value reported Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 38 of 39 across all data sources, across all years, & rounded up to the nearest multiple of 5. Note: If the estimated value is less than 2.5, then the value is labeled < 2.5.

What are the data sources used? ° USDA NASS ( United States Department of Agriculture's National Agricultural Statistics Service)   pesticide usage data from 1998 to 2003. ° NCFAP ( National Center for Food and Agricultural Policy)   pesticide usage data from 1997 & is only used if data is not available from the other sources. ° Private pesticide market research   pesticide usage data from 1998 to 2003. ° California DPR data can be requested separately.

What are the limitations to the data? ° Additional registered uses may exist but are not included because the available surveys do not report usage ( e. g., small acreage crops). ° Lack of reported usage data for the pesticide on a crop does not imply zero usage. ° Usage data on a particular site may be noted in data sources, but not quantified. ° In these instances, the site would not be reported in the SLUA. ° Non agricultural use sites ( e. g., turf, post harvest, mosquito control, etc.) are not reported in the SLUA. A separate request must be made to receive these estimates.

Who do I contact for further information and/ or questions on this SLUA? ° ( Jenna Carter, Botanist, BEAD)/( John O'Neill, Analyst, BEAD) ° (( 703) 308 8370, carter. jenna@ epa. gov)/ (( 703) 308 8118, Oneill. John @ epa. gov)

Tuesday, May 31, 2005 13: 46 Screening Level Estimates of Agricultural Uses of Triadimefon ( 109901) Sorted Alphabetically Crop Lbs. A. I. Percent Crop Treated Avg. Max. 1 Almonds < 500 < 1 < 2.5 2 Apples 4,000 5 10 3 Artichokes ( NCFAP ' 97) < 500 30 4 Asparagus ( NCFAP ' 97) < 500 15 5 Cabbage ( NCFAP ' 97) < 500 10 6 Cantaloupes < 500 < 1 10 7 Cherries < 500 < 1 < 2.5 8 Cucumbers < 500 < 1 < 2.5 9 Grapes 1,000 < 1 5 10 Honeydew < 500 5 5 11 Pears 1,000 5 5 12 Pumpkins 1,000 5 15 13 Raspberries ( NCFAP ' 97) < 500 50 14 Squash < 500 < 1 5 15 Sugar Beets < 500 < 1 < 2.5 Triadimefon Dietary Exposure Assessment  RED DP Barcode: 314778 Page 39 of 39 16 Watermelons < 500 < 1 5 17 Wheat 1,000 < 1 < 2.5 ______________________________________

All numbers rounded. '< 500' indicates less than 500 pounds of active ingredient. '< 2.5' indicates less than 2.5 percent of crop is treated.