States. The responsibility for making sure these public water systems
provide safe drinking water is shared among EPA, states, tribes, water
systems, and the public.

EPA sets national standards for drinking water based on sound science to
protect against health risks, considering available technology and
costs. These National Primary Drinking Water Regulations set enforceable
maximum contaminant levels (MCL) for particular contaminants in drinking
water or required ways to treat water to remove contaminants. Each
standard also includes requirements for water systems to test for
contaminants in the water to make sure standards are achieved. As listed
in 40 CFR 141.53 EPA has set the MCL at 0.1 mg/L for sodium chlorite.

To ensure that drinking water is safe, SDWA sets up multiple barriers
against pollution.  One such barrier is treatment.  Public water systems
are responsible for ensuring that contaminants in tap water do not
exceed the standards.  Water systems treat the water, and must test
their water frequently for specified contaminants and report the results
to states.  If a water system is not meeting these standards, it is the
water supplier's responsibility to notify its customers.

EPA sets primary drinking water standards through a three-step process:

First, EPA identifies contaminants that may adversely affect public
health and occur in drinking water with a frequency and at levels that
pose a threat to public health.  EPA identifies these contaminants for
further study, and determines contaminants to potentially regulate.

Second, EPA determines a maximum contaminant level goal for contaminants
it decides to regulate.  This goal is the level of a contaminant in
drinking water below which there is no known or expected risk to health.
 These goals allow for a margin of safety.

Third, EPA specifies a maximum contaminant level, the maximum
permissible level of a contaminant in drinking water which is delivered
to any user of a public water system.  These levels are enforceable
standards, and are set as close to the goals as feasible.  SDWA defines
feasible as the level that may be achieved with the use of the best
technology, treatment techniques, and other means which EPA finds (after
examination for efficiency under field conditions) are available, taking
cost into consideration.  When it is not economically or technically
feasible to set a maximum level, or when there is no reliable or
economic method to detect contaminants in the water, EPA instead sets a
required Treatment Technique which specifies a way to treat the water to
remove contaminants.

EPA sets national standards for tap water which help ensure consistent
quality in our nation's water supply.  EPA prioritizes contaminants for
potential regulation based on risk and how often they occur in water
supplies.  (To aid in this effort, certain water systems monitor for the
presence of contaminants for which no national standards currently exist
and collect information on their occurrence). EPA sets a health goal
based on risk (including risks to the most sensitive populations, e.g.,
infants, children, pregnant women, the elderly, and the
immuno-compromised).  EPA then sets a legal limit for the contaminant in
drinking water or a required treatment technique.  This limit or
treatment technique is set to be as close to the health goal as
feasible.

EPA also performs a cost-benefit analysis and obtains input from
interested parties when setting standards.

EPA promulgated regulations to control microbial pathogens and
disinfectants/disinfection byproducts in drinking water in a multi-stage
process that dates back to a 1992-93 negotiated rulemaking, which was
affirmed by Congress in the 1996 Amendments to the SDWA.  The
regulations address complex risk trade-offs between the two different
types of contaminants and were promulgated with significant stakeholder
input.  (65 FR 83016)

Even though, the FFDCA standard in section 408 is a risk-based standard
and the SDWA is a cost-benefit standard, the Agency believes we must
consider the harm to human health broadly.  In doing so, the EPA does
not believe it to be prudent to cancel the drinking water disinfectant
use of chlorine dioxide and sodium chlorite as that action could
potentially result in harming the public at large.  The Agency believes
the mitigation measures required in this document for the food uses that
require pesticide tolerances will reduce exposures from those uses such
that the exposures will result in a minimal addition to the exposure
that occurs from drinking water.  The Agency is reasonably certain that
this minimal addition does not cause harm to human health, and is
therefore safe under section 408(b) of the FFDCA.

c.	Drinking Water Risk Mitigation

	Drinking water risks of concern were identified for infants.  Drinking
water exposure also played a role in the aggregate risks of concern for
children.

The chlorite ion (ClO2-) is a major degradation product resulting from
the reaction of chlorine dioxide with inorganic and organic constituents
in the water.  When free chlorine is used after the application of
chlorine dioxide in the treatment process, chlorite is oxidized to
chlorate.  Chlorite oxidizes to chlorate over a period of time in water
and soil.  This conversion will continue over time as the water travels
through the distribution system.  Treatment of public water supplies is
necessary to kill pathogens that may exist in the drinking water, such
as cholera, typhoid, and dysentery.  Outbreaks of these diseases
decreased significantly when disinfection of the water systems was
introduced in the early 1900s.  While there are many important public
functions of water treatment, the Agency is taking steps to limit the
exposure of chlorite ion as a disinfection byproduct to the public.
Approximately six percent of U.S. water treatment facilities use
chlorine dioxide for water disinfection.

In addition, the Chlorine Dioxide Panel recently submitted a study that
evaluated whether the components of the baby formula react with the
chlorite in drinking water to form chloride, which is not of concern in
drinking water because it is easily absorbed and metabolized by the
body.  A preliminary review of the data suggests that the components of
the baby formula, such as ascorbic acid, react with chlorite in the
drinking water.  Specifically, within five minutes of adding the formula
to the water, approximately one third of the chlorite combines with the
ingredients in the infant formula to form chloride.

The Agency is not currently able to quantify the reduction of exposure
to chlorite that occurs due to binding of chlorite with ingredients
present in the baby formula.  However, based on its initial evaluation
of the existing data, the Agency believes that for all infants the %
cPAD will likely be close to the target of 100, and not of concern.  The
Agency will require additional data on the breakdown of chlorite in baby
formula as confirmatory data.

As mentioned above, the aggregate risks to children 1-6 are mitigated by
the consideration discussed concerning dietary exposures from food.

d.	Residential Risk Mitigation   XE "IV. Risk Management,
Reregistration, and Tolerance Reassessment Decision:D. Regulatory
Rationale: 1. Human Health Risk Management: c. Residential Risk
Mitigation"

Residential Handler

Residential risks for handlers were calculated for short- and
intermediate-term dermal and inhalation exposures.  Risks of concern
were identified for homeowners who place tablets in swimming pools/spas
with their bare hands (MOE=46).  This risk will be mitigated if the
homeowner wears gloves while placing the tablet in the swimming pool/spa
(MOE=500).  Although the Agency does not normally require the use of
personal protective equipment such as gloves, on pesticidal products
that are used in and around the home, the use of gloves in this case is
thought to be prudent since the Agency expects that, given the nature of
pool products of this kind, residents are likely to wear gloves based on
a perception of the danger of the chemicals along with the label
warnings and precautions.  This is not necessarily expected to be true
of most other residential products where Personal Protective Equipment
(PPE)  would not be considered an effective mitigation measure nor
should this be viewed as a precedent for requiring use of PPE for
residential use products.  All other exposure and risk estimates for
residential handler scenarios are below the Agency’s level of concern.

			ii.	Residential Post-Application

The Agency has conducted dermal, incidental oral and inhalation exposure
assessments for residential post-application scenarios.

The residential use of chlorine dioxide/sodium chlorite continuous
release deodorizers are of concern.  To mitigate this risk, the
following use sites for the continuous release deodorizer are ineligible
for reregistration and must be deleted:  shoes, closets, laundry
hampers, bags, drawers, basements, boat cabins, trash bags, and
additional deodorizing uses.  The remaining use sites will be in an
outdoor or commercial setting where people are not likely to have
prolonged exposure, e.g., dumpsters. Therefore, the risks from this use
pattern would be considered to be no longer of concern.  The registrant
has agreed to voluntarily cancel these use patterns.

Based on the risk assessment, a post-application inhalation concern was
identified for adults and children exposed to carpets treated with
chlorine dioxide/sodium chlorite.  In order to mitigate this risk, the
registrants must prohibit residential use; however, a commercial
application to carpet will remain registered with a one hour Restricted
Entry Interval (REI).

e.	Aggregate Risk Mitigation

Intermediate- and Short-Term

The short- and intermediate- risks to infants are primarily driven by
exposure to residues in drinking water.  These exposures and risks are
mitigated as described in the drinking water section above.   The short-
and intermediate- risks to children are largely driven by the dietary
exposure through food.  The characterization and mitigation described
above for risks from exposure to residues in food address the aggregate
risk as well.  Based on these characterization and mitigation measures,
the Agency believes that aggregate risks are not of concern.

Chronic

The chronic risks to infants are primarily driven by exposure to
residues in drinking water.  These exposures and risks are mitigated as
described in the drinking water section above.   The chronic risks to
children are largely driven by the dietary exposure through food.  The
characterization and mitigation described above for risks from exposure
to residues in food address the aggregate risk as well.  Based on these
characterization and mitigation measures, the Agency believes that
aggregate risks are not of concern.

f.	  XE "IV. Risk Management, Reregistration, and Tolerance Reassessment
Decision:D. Regulatory Rationale: 1. Human Health Risk Management: b.
Drinking Water Risk Mitigation"  Occupational Risk Mitigation   XE "IV.
Risk Management, Reregistration, and Tolerance Reassessment Decision:D.
Regulatory Rationale: 1. Human Health Risk Management: d. Occupational
Risk Mitigation"

i.	Occupational Handler   XE "IV. Risk Management, Reregistration, and
Tolerance Reassessment Decision:D. Regulatory Rationale: 1. Human Health
Risk Management: d. Occupational Risk Mitigation: i. Handler Exposure"

Dermal Risks from Applications in Agricultural and Medical Premises

	The Agency has conducted dermal and inhalation exposure assessments for
handlers applying chlorine dioxide in an occupational setting.  Based on
this assessment, dermal risks of concern were identified for handlers
applying chlorine dioxide:  to hard surfaces using a low pressure hand
wand (MOE=31); to hard surfaces using a mop (MOE=70); to animal
transport vehicles/tractor trailer using a foam application (MOE=8 w/
gloves); and in food handling, commercial/institutional, and medical
premises and equipment using a mop (MOE=66 for commercial and MOE=3 for
medical).

	These scenarios were evaluated using highly conservative assumptions
including the use of a 100% dermal absorption factor that assumes that
all chlorine dioxide/sodium chlorite that contacts the skin will be
absorbed.  Further, high-end application and use parameters were used to
develop the risk estimates.  Therefore, the Agency does not expect that
actual exposures would be as high as those calculated in the risk
assessment.

	For these scenarios, the risks will be mitigated by requiring handlers
to wear gloves during application.  Although there is no data to assess
most scenarios with handlers wearing gloves, the Agency is confident
that this mitigation will protect occupational handlers.  Therefore,
these risks are not of concern to the Agency.

	For the foam application, the Chlorine Dioxide Panel has submitted
information indicating that the Agency has overestimated the risks
associated with this use.  Specifically, the information indicates that
the number of vehicles treated in a day is eight, using two quarts of
solution per vehicle.  The Agency assessed an application rate of 4 to 6
gallons per minute and assumed that this product was applied for ten
minutes per day.  Subsequently, EPA determined that the assessed
application rate was too high.  Based on the revised application rate,
the Agency does not have a concern with this risk, provided that gloves
are worn during the treatment.  Additional details can be found in
“Chlorine Dioxide Occupational and Residential Exposure Assessment,”
dated August 2, 2006.

Dermal Risks from Swimming Pool Applications

Occupational risks for handlers were calculated for short- and
intermediate-term dermal exposures.  Risks of concern were identified
for handlers who place tablets in public swimming pools with their bare
hands (MOE=5).  This risk will be mitigated if the handlers wear gloves
while placing the tablet in the swimming pool (MOE=120), and no
additional mitigation is required.

Inhalation Risks from Non-fogging Applications

There is the potential for the off-gassing of chlorine dioxide during
some non-fogging occupational applications that are not totally enclosed
(e.g., aqueous solution sprays, mopping, open pouring, etc).  To address
the potential for inhalation exposure, EPA has obtained worker air
concentration measurements from OSHA for 7 industry Standard Industrial
Classification (SIC) codes.  The monitored air concentrations for
workers are stored in OSHA’s data base known as the Integrated
Management Information System (IMIS).  The inhalation endpoint selected
by EPA for an 8-hour time-weighted average (TWA) is 0.003 ppm, just
below OSHA’s limit of detection of 0.004 ppm.  Of the 33 TWA
measurements available in IMIS, 21 of those measurements were below the
limit of detection.  In addition, of the 33 TWA measurements, only 3
were at or above the OSHA PEL of 0.1 ppm.  At this point in time,
monitoring to EPA’s level of concern (i.e., 0.003 ppm) is not
technically feasible.  However, 64 percent of the samples indicate that
the air concentrations of chlorine dioxide are near or below the level
of concern.  Therefore, for non fogging uses of chlorine dioxide such as
open pouring of aqueous solutions or bystanders in pulp and paper mills
no additional mitigation is deemed necessary at this time.

Inhalation Risks from Fogging Applications

Inhalation exposure to the release of chlorine dioxide gas during the
mixing/loading/application of products producing chlorine dioxide may
occur.  There is a greater potential for chlorine dioxide gas formation
from fogging then an aqueous-based application such as mopping.  The air
concentration in a fogged area should be below the occupational RfC of
0.003 ppm before the room is entered by persons not wearing respiratory
protection.

However, one scenario based on labeled application rates allows chlorine
dioxide fogging and misting applications while workers are in the room
if the level of chlorine dioxide does not exceed the TLV-TWA of 0.1 ppm.
 Based on this scenario, the occupational RfC of 0.003 ppm could be
exceeded if handlers are present.  Therefore, people must vacate the
premises during fogging treatments and a one-hour restricted entry
interval (REI) is required to address this risk.

Environmental Risk Management

Environmental risk for the once-through cooling tower use of chlorine
dioxide/sodium chlorite has been assessed because it has the most
potential for environmental exposure.  The risk assessment was conducted
using sodium chlorite endpoints because under environmental these
conditions, chlorine dioxide converts mostly into chlorite ions.

Acute risk is anticipated for aquatic organisms from the use of chlorine
dioxide/sodium chlorite in once-through cooling towers.  At the highest
doses on current labels (25 ppm), there is risk to freshwater and
marine/estuarine fish and invertebrates and aquatic plants, and at the
lowest doses there is risk only to freshwater invertebrates.  To
mitigate this risk, the maximum application rate for this use pattern
must be reduced from 25 ppm to 5 ppm for intermittent applications.

Chronic risk to aquatic organisms cannot be assessed at this time due to
the lack of chronic toxicity endpoints for fish and aquatic
invertebrates.  When the required aquatic chronic toxicity testing
described above is submitted, chronic risk to these organisms will be
assessed. All other exposure and risk estimates are below the Agency’s
level of concern.

3.	Other Labeling Requirements   XE "IV. Risk Management,
Reregistration, and Tolerance Reassessment Decision:D. Regulatory
Rationale: 3. Other Labeling Requirements"

	In order to be eligible for reregistration, various use and safety
information will be included in the labeling of all end-use products
containing chlorine dioxide and sodium chlorite.  For the specific
labeling statements and a list of outstanding data, refer to Section V
of this RED document.

4.	Threatened and Endangered Species Considerations   XE "IV. Risk
Management, Reregistration, and Tolerance Reassessment Decision:D.
Regulatory Rationale: 4. Threatened and Endnagered Species
Considerations"

			a.	The Endangered Species Program

  XE "IV. Risk Management, Reregistration, and Tolerance Reassessment
Decision:D. Regulatory Rationale: 4. Threatened and Endnagered Species
Considerations: a. The Endangered Species Program"

Section 7 of the Endangered Species Act, 16 U.S.C. Section 1536(a)(2),
requires all federal agencies to consult with the National Marine
Fisheries Service (NMFS) for marine and anadromous listed species, or
the United States Fish and Wildlife Services (FWS) for listed wildlife
and freshwater organisms, if they are proposing an "action" that may
affect listed species or their designated habitat.  Each federal agency
is required under the Act to insure that any action they authorize,
fund, or carry out is not likely to jeopardize the continued existence
of a listed species or result in the destruction or adverse modification
of designated critical habitat.  To jeopardize the continued existence
of a listed species means "to engage in an action that reasonably would
be expected, directly or indirectly, to reduce appreciably the
likelihood of both the survival and recovery of a listed species in the
wild by reducing the reproduction, numbers, or distribution of the
species." 50 C.F.R. § 402.02.

To facilitate compliance with the requirements of the Endangered Species
Act subsection (a)(2) the Environmental Protection Agency, Office of
Pesticide Programs has established procedures to evaluate whether a
proposed registration action may directly or indirectly reduce
appreciably the likelihood of both the survival and recovery of a listed
species in the wild by reducing the reproduction, numbers, or
distribution of any listed species (U.S. EPA 2004).  After the
Agency’s screening-level risk assessment is performed, if any of the
Agency’s Listed Species LOC Criteria are exceeded for either direct or
indirect effects, a determination is made to identify if any listed or
candidate species may co-occur in the area of the proposed pesticide
use.  If determined that listed or candidate species may be present in
the proposed use areas, further biological assessment is undertaken.
The extent to which listed species may be at risk then determines the
need for the development of a more comprehensive consultation package as
required by the Endangered Species Act.

For certain use categories, the Agency assumes there will be minimal
environmental exposure, and only a minimal toxicity data set is required
(Overview of the Ecological Risk Assessment Process in the Office of
Pesticide Programs U.S. Environmental Protection Agency - Endangered and
Threatened Species Effects Determinations, 1/23/04, Appendix A, Section
IIB, pg.81).  Chemicals in these categories therefore do not undergo a
full screening-level risk assessment, and are considered to fall under a
no effect determination.  The screening level model used in this
assessment indicates that there may be acute risks to listed aquatic
organisms from the once through cooling tower use of chlorine
dioxide/sodium chlorite.  Further, potential indirect effects on any
species dependent upon a species that experiences effects from use of
chlorine dioxide/sodium chlorite cannot be precluded based on the
screening level ecological risk assessment.  These findings are based
solely on EPA’s screening level assessment and do not constitute
“may effect” findings under the Endangered Species Act.  Due to
these circumstances, the Agency defers making a determination for the
cooling tower use of chlorine dioxide and sodium chlorite until
additional data and modeling refinements are available.  At that time,
the environmental exposure assessment of the cooling tower of chlorine
dioxide will be revised, and the risks to Listed Species will be
reconsidered.

b.	General Risk Mitigation   XE "IV. Risk Management, Reregistration,
and Tolerance Reassessment Decision:D. Regulatory Rationale: 4.
Threatened and Endnagered Species Considerations: b. General Risk
Mitigation"

	Chlorine dioxide and sodium chlorite end use products (EPs) may also
contain other registered pesticides.  Although the Agency is not
proposing any mitigation measures for products containing Chlorine
dioxide and sodium chlorite specific to federally listed threatened and
endangered species, the Agency needs to address potential risks from
other end-use products.  Therefore, the Agency requires that users adopt
all threatened and endangered species risk mitigation measures for all
active ingredients in the product.  If a product contains multiple
active ingredients with conflicting threatened and endangered species
risk mitigation measures, the more stringent measure(s) must be adopted.

V.	What Registrants Need to Do  XE "V. What Registrants Need To Do"

	The Agency has determined that chlorine dioxide and sodium chlorite are
eligible for reregistration provided that:  (i) additional data that the
Agency intends to require confirm this decision; and (ii) the risk
mitigation measures outlined in this document are adopted, and (iii)
label amendments are made to reflect these measures.  To implement the
risk mitigation measures, the registrants must amend their product
labeling to incorporate the label statements set forth in the Label
Changes Summary Table in Section B below (Table 13).  The additional
data requirements that the Agency intends to obtain will include, among
other things, submission of the following:

	For chlorine dioxide and sodium chlorite technical grade active
ingredient products, the registrant needs to submit the following items:

Within 90 days from receipt of the generic data call in (DCI):

1.  Completed response forms to the generic DCI (i.e., DCI response form
and requirements status and registrant’s response form); and,

	2.  Submit any time extension and/or waiver requests with a full
written justification.

Within the time limit specified in the generic DCI:

1.  Cite any existing generic data which address data requirements or
submit new generic data responding to the DCI.

Please contact ShaRon Carlisle at<PHONE_NUMBER> with questions
regarding generic reregistration.

By US mail:						By express or courier service:

Document Processing Desk (DCI/AD)		Document Processing Desk (DCI/AD)

ShaRon Carlisle					ShaRon Carlisle

US EPA (7510P)					Office of Pesticide Programs (7510P)

1200 Pennsylvania Ave., NW				One Potomac Yard (South Building),
Washington, DC 20460				2777 South Crystal Drive

							Arlington, VA 22202

For end use products containing the active ingredient chlorine dioxide
and sodium chlorite, the registrant needs to submit the following items
for each product.

Within 90 days from the receipt of the product-specific data call-in
(PDCI):

1.  Completed response forms to the PDCI (PDCI response form and
requirements status and registrant’s response form); and,

2.  Submit any time extension or waiver requests with a full written
justification.

Within eight months from the receipt of the PDCI:

1.  Two copies of the confidential statement of formula (CSF) (EPA Form
8570-4);

2.  A completed original application for reregistration (EPA Form
8570-1).  Indicate on the form that it is an “application for
reregistration”;

3.  Five copies of the draft label incorporating all label amendments
outlined in Table 15 of this document;

4.  A completed form certifying compliance with data compensation
requirements (EPA Form 8570-34);

5.  If applicable, a completed form certifying compliance with cost
share offer requirements (EPA Form 8570-32); and,

6.  The product-specific data responding to the PDCI.

	Please contact Emily Mitchell at<PHONE_NUMBER> with questions
regarding product reregistration and/or the PDCI.  All materials
submitted in response to the PDCI should be addressed as follows:

By US mail:						By express or courier service:

Document Processing Desk (PM-32)		            Document Processing Desk
(PM-32)

Emily Mitchell					Emily Mitchell

US EPA (7510P)					Office of Pesticide Programs (7510P)

1200 Pennsylvania Ave., NW				One Potomac Yard (South Building),
Washington, DC 20460				2777 South Crystal Drive

A.	Manufacturing Use Products   XE "V. What Registrants Need to Do:A.
Manufacturing Use Products"

		1.	Additional Generic Data Requirements   XE "V. What Registrants Need
to Do:A. Manufacturing Use Products: 1. Additional Generic Data
Requirements"

The generic database supporting the reregistration of chlorine dioxide
and sodium chlorite has been reviewed and determined to be substantially
complete.  However, the following additional data requirements have been
identified by the Agency as confirmatory data requirements.  A generic
data call-in will be issued at a later date.  Several Ecological studies
are being required to support the once-through cooling tower use of
chlorine dioxide/sodium chlorite.

The risk assessment noted deficiencies in the surrogate dermal and
inhalation exposure data available from the Chemical Manufacturers
Association (CMA) data base.  Therefore, the Agency is requiring
confirmatory data to support the uses assessed with the CMA exposure
data within this risk assessment.  The risk assessment also noted that
many of the use parameters (e.g., amount handled and duration of use)
were based on   SEQ CHAPTER \h \r 1 professional judgments.  Therefore,
descriptions of human activities associated with the uses assessed are
required as confirmatory.

Table 15.  Confirmatory Data Requirements for Reregistration

Guideline Study Name	New OPPTS Guideline No.	Old Guideline No.

Fish early life-stage testing-freshwater	850.1300	72-4

Invertebrate life-cycle testing - freshwater	850.1400	72-4b

Seedling emergence dose-response in rice	850.4225	123-1

Vegetative vigor dose-response in rice	850.4250	123-1

Aquatic vascular plant dose-response toxicity- Lemna sp.	850.4400	123-2

Acute algal dose-response toxicity - 4 species	850.5400	123-2

Indoor Inhalation Exposure and Applicator Exposure Monitoring Data
Reporting 	875.1400 and 875.1600	234 and 236

Indoor Dermal Exposure and Applicator Exposure Monitoring Data Reporting
875.1200 and 875.1600	233 and 236

Descriptions of Human Activity	875.2800	133-1

Carcinogenicity	870.4200	83-2

Fate of chlorite in baby formula	Special study	Special study

Use and Usage Information on the Percent of Fruits and Vegetables that
are treated with Chlorine Dioxide

2.  	Labeling for Technical and Manufacturing Use Products   XE "V. What
Registrants Need to Do:A. Manufacturing Use Products: 2. Labeling for
Technical and Manufacturing Use Products"

	To ensure compliance with FIFRA, technical and manufacturing use
product (MP) labeling should be revised to comply with all current EPA
regulations, PR Notices and applicable policies.  The Technical and MP
labeling should bear the labeling contained in Table 16, Label Changes
Summary Table.

B.  	End-Use Products   XE "V. What Registrants Need to Do:B. End-Use
Products"

		1.	Additional Product-Specific Data Requirements   XE "V. What
Registrants Need to Do:B. End-Use Products: 1. Additional
Product-Specific Data Requirements"

	Section 4(g)(2)(B) of FIFRA calls for the Agency to obtain any needed
product-specific data regarding the pesticide after a determination of
eligibility has been made.  The Registrant must review previous data
submissions to ensure that they meet current EPA acceptance criteria and
if not, commit to conduct new studies.  If a registrant believes that
previously submitted data meet current testing standards, then the study
MRID numbers should be cited according to the instructions in the
Requirement Status and Registrants Response Form provided for each
product.

	A product-specific data call-in, outlining specific data requirements,
will follow this RED at a later date.

		2.	Labeling for End-Use Products   XE "V. What Registrants Need to
Do:B. End-Use Products: 2. Labeling for End-Use Products"

	Labeling changes are necessary to implement measures outlined in
Section IV above.  Specific language to incorporate these changes is
specified in Table 16.

	Registrants may generally distribute and sell products bearing old
labels/labeling for 26 months from the date of the issuance of this
Reregistration Eligibility Decision document.  Persons other than the
registrant may generally distribute or sell such products for 52 months
from the approval of labels reflecting the mitigation described in this
RED.  However, existing stocks time frames will be established
case-by-case, depending on the number of products involved, the number
of label changes, and other factors.  Refer to “Existing Stocks of
Pesticide Products; Statement of Policy,” Federal Register, Volume 56,
No. 123, June 26, 1991.

a.	Label Changes Summary Table

In order to be eligible for reregistration, amend all product labels to
incorporate the risk mitigation measures outlined in Section IV.  The
following table describes how language on the labels should be amended.

Table 16.  Labeling Changes Summary Table

Description	Amended Labeling Language	Placement on Label

Manufacturing Use Product

Supported Use Sites	“Only for formulation into antimicrobial products
for use in: agricultural/farm premises, structures, buildings, and
equipment; dairy farm milk handling facilities, equipment, storage
rooms, houses, and sheds; food processing plants, food handling, food
distribution equipment and premises; eating establishments premises and
equipment; commercial, institutional, and industrial premises and
equipment (floors, walls, storage areas); domestic dwellings, food
handling areas, indoor premises; and medical institutional critical care
and non-critical care premises, human water systems, swimming pools and
industrial processes and water systems.”

For Formulation into antimicrobial products for use in: animal transport
vehicles, carpets,  fountains/water displays/decorative ponds/, once-
through and recirculating industrial commercial cooling water systems,
pulp/paper mill water systems, and swimming pools, mushroom
facilities/premises and equipment, egg handling equipment and rooms, egg
washing treatment, chick room, poultry houses chiller water/carcass
spray, food processing plants/equipment, dairies/breweries and bottling
plants/equipment, fruit and vegetable rinse/process water and tank
lines, potable drinking water, water storage systems (aircrafts boats,
RVs, off-shore oil rigs), water filtration systems, ventilation systems.
	Directions for Use

PPE

	Precautionary Statements

Ecological Effects Language Required by the RED and PR Notice 93-10 and
95-1	"This product is toxic to fish, aquatic invertebrates, oysters, and
shrimp.  Do not discharge effluent containing this product into lakes,
streams, ponds, estuaries, oceans, or other waters unless in accordance
with the requirements of a National Pollution Discharge Elimination
System (NPDES) permit and the permitting authority has been notified in
writing prior to discharge.  Do not discharge effluent containing this
product to sewer systems without previously notifying the local sewage
treatment plant authority.  For guidance contact your State Water Board
or Regional Office of the EPA."	Environmental Hazard Statements

End Use Products Intended for Occupational Use

Application Restrictions-For Occupational Handler -Dermal (Application
to hard surfaces)	“Handlers applying chlorine dioxide in an
occupational setting must wear gloves.”

low pressure hand wand (hard surfaces)

mop (hard surfaces)

foam application (animal transport vehicles/tractor trailer)

mop (food handling, commercial/institutional and medical
premises/equipment)

	Precautionary Statements under:  Hazards to Humans and Domestic Animals
(Immediately Following Engineering Controls

Application Restrictions-For Occupational Handler -Dermal (Tablets into
public swimming pools)	“Occupational handler must wear gloves while
placing the tablet in the swimming pool”	Precautionary Statements
under:  Hazards to Humans and Domestic Animals (Immediately Following
Engineering Controls

Application Restrictions-For Occupational Handler –Inhalation
(Fogging Use)	“People must vacate the premises during fogging
treatments; a one-hour restricted entry interval (REI) is required.”
Precautionary Statements under:  Hazards to Humans and Domestic Animals
(Immediately Following Engineering Controls

Application Restrictions-For Occupational – Inhalation (Carpet
Treatment)	"Not for residential use.  For nonresidential use, a one-hour
restricted entry interval is required."	Precautionary Statements under:
Hazards to Humans and Domestic Animals (Immediately Following
Engineering Controls

Application Restrictions-For Occupational Post-Application  (Once
through use)	“Reduce the application rate from 25 ppm to 5 ppm for
intermittent applications.”

	End Use Products Intended for Residential Use

Application Restrictions-For Residential Handler -Dermal (Tablets into
pools/spas)	“Residential handler (homeowner) must wear gloves while
placing the tablet in the swimming pool/spa”	Precautionary Statements
under:  Hazards to Humans and Domestic Animals (Immediately Following
Engineering Controls

Application Restrictions-For Residential Post-Application – Inhalation
(Continuous release deodorizers) 	“Restrict to outdoor use only. Do
not use indoors (e.g., use in shoes, closets, laundry hampers, bags,
drawers, basements, boat cabins, trash bags, and any additional
deodorizing uses)”	Precautionary Statements under:  Hazards to Humans
and Domestic Animals (Immediately Following Engineering Controls

Application Restrictions-For Residential Post-Application – Inhalation
(Carpet Treatment)	“Residential use is prohibited.”	Precautionary
Statements under:  Hazards to Humans and Domestic Animals (Immediately
Following Engineering Controls

Dietary

Fruit and vegetable wash	“Fruits and vegetables treated with chlorine
dioxide must be blanched, cooked, or canned before consumption or
distribution in commerce”	Precautionary Statements under:  Hazards to
Humans and Domestic Animals (Immediately Following Engineering Controls

VI. APPENDICES  XE "VI. Appendices"

Appendix A - Chlorine Dioxide, PC Code 020503

Use Site	Formulation/ EPA Reg No.	Method of Application	Application
Rate/ No. of applications	Use Limitations

Agricultural premises and equipment

Agricultural Storage Facilities

(Containers, Trailers, Rail Cars, Vessels)	Soluble Concentrate

9150-11	Foaming Wand	One quart to system that delivers 4-6 gallons per
minute of dilution water

10 minutes contact time	Preclean with water to remove debris and dirt.

Mushroom Facilities: (food Contact) Stainless Steel Tanks, Transfer
Lines, On-line Equipment, Picking Baskets	Soluble Concentrate

9150-2, 9150-3

9804-1, 58300-16, 58300-19

	Flush equipment with sanitizing solution	Use-solution calls for 100-200
ppm total available chlorine dioxide	Clean equipment and surfaces
thoroughly using a suitable detergent and rinse with water before
sanitizing.

Mushroom Facilities (non-food contact): disinfect walls ceilings and
floors	Soluble Concentrate

9150-2, 9150-3

9804-1, 58300-16, 58300-19	Spraying device	300-500 ppm total available
chlorine dioxide

1,000 ppm for control of mold and slime on walls	Remove all gross filth
from areas prior to disinfection. Never reuse activated solutions

Avoid contact with food or food contact surfaces.

Potato Facilities: (food Contact) Stainless Steel Tanks, Transfer Lines,
On-line Equipment, Handling equipment	Soluble Concentrate

9804-1	Fill, flush, immerse or spray	Use-solution calls for 100 ppm
total available chlorine dioxide	None stated

Potato Facilities: walls, ceilings floors, planting and harvesting
equipment and truck beds

Disinfection	Soluble Concentrate

9804-1	Spray	10 minute contact time	Always use an applicable NIOSH/MSHA
approved respirator appropriate for chlorine dioxide.

Potato Facilities: potato rinse tanks, flumes and lines	Soluble
Concentrate

9804-1	Chemical Feed pump or injector system	5 ppm	After Treatment
Potatoes must be rinsed with potable water.

Potato Storage: Potato rinse and humidification water	Soluble
Concentrate

9804-5

9150-12	Spray, mist and fogger	200 to 400 ppm 	No more than 20 gallons
of product concentrate per month to humidification water per 500 tons of
potatoes in storage.

Always use an applicable NIOSH/MSHA approved respirator appropriate for
chlorine dioxide.

Disinfection of Animal Confinement Facilities (Poultry Houses, Swine
Pens, Calf Barns and Kennels	Soluble Concentrate

9150-2, 9150-3

9804-1	Use Commercial Sprayer to saturate all surfaces	Working Solution
containing 300 to 500 ppm available Chlorine Dioxide	Remove all animals
and feed from premises. Remove all litter and manure from premises of
facilities. Empty all troughs , racks and other feeding equipment/
watering appliances.

Thoroughly clean all surfaces with soap and detergent and rinse with
water.

	Soluble Concentrate

9150-11	None Stated	1000 ppm	Remove all animals, bedding, litter,
droppings and manure. Pre-clean

Animal Transport Vehicles	Soluble Concentrate

9150-11	Foaming Wand	One quart to system that delivers 4-6 gallons per
minute of dilution water

10 minutes contact time	Preclean with water to remove debris and dirt.

Control for odor and Slime forming  Bacteria in Animal Confinement
Facilities	Soluble Concentrate

9150-2, 9150-3	Commercial sprayer to saturate all surfaces	1,000 ppm
Remove all litter and manure from premises and thoroughly clean all
surfaces with soap or detergent and rinse with clean water

Shoe Bath	Soluble Concentrate	Immersion	1 to 2 ounces per galloon of
water	Change Shoe bath solution daily or when solution appears soiled.

Poultry House Disinfection:

Poultry Chiller Water/ Carcass spray	Soluble concentrate

9150-2, 9150-3	Dip Carcass	0.5 to 3 ppm for Chiller Water

70 ppm for Carcass Spray	None stated

Poultry Drinking Water	Soluble concentrate

9150-2, 9150-3	Add to water	5ppm for fouled water

0.5 to 1.0ppm for control	None stated

Egg Room/  Hatching Area

Incubator Room

Tray Washing Room and Loading Platform	Soluble Concentrate

9150-2, 9150-3	High pressure sprayer	20 ppm for pre wash w/ sprayer

390 ppm to preclean floors

1,000 ppm treatment w/ fogger	None Stated

	10589-3	Spray	5 oz. per gallon/ 1406 ppm (mixed with DDAC)	Remove gross
filth and heavy soil prior to application of the disinfecting solution

Chick Room, Chick Grading Box an Sexing room	Soluble concentrate

9150-2, 9150-3	Fogger, Mop	1,000 ppm w/ fogger

390 ppm to mop floors	None Stated

Hand Dip for Poultry Workers	Soluble concentrate

9150-2, 9150-3	Dip	50 ppm	None Stated

Horticulture uses

Work Area and Benches

	Ready to use Solution 9150-11	Cloth, mop, sponge or sprayer	9 fl oz per
gallon/ 253 ppm	Do not Apply directly to Plant Material

Horticulture uses

Pots and Flats	Ready to use Solution 9150-11	Soak	18 fl oz per gallon/
506 ppm	Remove all loose soil and plant residue prior to application

Horticulture uses

Cutting Tools	Ready to use Solution 9150-11	Soak	9 fl oz per gallon/ 253
ppm	None Stated

Horticulture uses

Bulbs	Ready to use Solution 9150-11	Soak	9 to 18 fl oz per gallon/ 253
ppm to 506 ppm	None Stated

Horticulture uses

Greenhouse Glass, Walkways and under Bench Areas	Ready to use Solution
9150-11	Spray	4 to 9 fl oz per gallon/ 112 ppm to 253 ppm	None Stated

Evaporative Coolers	Ready to use Solution 9150-11	Add to water	4 to 9
fl. oz per gallon / 112 ppm to 253 ppm. Repeat as needed or every 14
days	None Stated

Rention Basins and Ponds	Ready to use Solution 9150-11	Add to Basin	4-9
fl oz. per 100 gallons/ 2 to 5 ppm	Do not use where fish are present

Decorative Pools, Fountains and Water Displays	Ready to use Solution
9150-11	Add to Pools	9-18 fl oz per 100 gallons/ 5 to 10 ppm	Do not use
where fish are present.

Food handling/ storage establishments premises and equipment

Food Processing Plants

(Poultry, Meat, Fish)

Food Contact Surface Sanitizer	Soluble Concentrate

9150-2, 9150-3

9804-9

9804-1

	1 minute contact time	200ppm- 1,000 ppm total available chlorine
Dioxide

50 ppm

100 ppm	Preclean and rinse equipment. Do not reuse solution. Do not
rinse treated surface

Food Processing Plants

(Poultry, Meat, Fish)

Non-Food contact disinfectant

	Soluble Concentrate

9804-9

9804-1

	Spray thoroughly wet for 10 minutes	500 ppm 	Never reuse activated
solutions

	Soluble Concentrate

10589-3	Spray	5 oz. per gallon/ 1406 ppm (mixed with DDAC)	Remove gross
filth and heavy soil prior to application of the disinfecting solution

Dairies, Breweries and Bottling Plants

Non-Food contact disinfectant

	Soluble Concentrate, Ready to use Solution

9804-9

9804-1	Spray thoroughly wet for 10 minutes	500 ppm	Never reuse activated
solutions

Dairies	Soluble Concentrate

10589-3	Spray	5 oz. per gallon/ 1406 ppm (mixed with DDAC)	Remove gross
filth and heavy soil prior to application of the disinfecting solution

Dairies, Breweries and Bottling Plants

Food Contact Surface Sanitizer	Soluble Concentrate, Ready to use
Solution

9150-2, 9150-3

9804-9

9804-1	1 minute contact time	200ppm- 1,000 ppm total available chlorine
Dioxide

50ppm

100ppm	Preclean and rinse equipment. Do not reuse solution. Do not rinse
treated surface

Ice Making Plants and Machinery	Soluble Concentrate, Ready to use
Solution

9804-9

9804-1

9804-5	Chemical Feed Pump or Injector System	20 ppm

	Lube Additive for Moving Conveyors and Chains	Soluble Concentrate,
Ready to use Solution

9804-9

9804-1	Inject into distribution system	10- 20 ppm	Preclean and sanitize
all conveyor surfaces and associated structures

Canning Retort and Pasteurizer Cooling Water	Soluble concentrate, Ready
to use Solution

9150-2, 9150-3

9804-9

	Controlled Chemical Feed Pump 	5ppm

	Stainless Steel Transfer Lines, Hydrocoolers and Pasteurizers	Soluble
concentrate, Ready to use Solution

9150-2, 9150-3

9804-9

9804-1	Mix and fill lines and Equipment overnight	20 ppm 	Preclean
equipment or line thoroughly

Process Water for Vegetable Rinses, Tanks Lines	Soluble Concentrate

9150-2, 9150-3

9804-1	Chemical Feed Pump or injector system	5 ppm	Preclean all tanks,
flumes and lines with suitable detergent.

Fruit and Vegetable Rinse	Soluble concentrate

9150-2, 9150-3

9804-1	Immersion	1/3 fl. to 1 gallon of water per 25 gallons of water

5 ppm	Prewash whole fruits and vegetables with clean potable water.

Human Water Systems

Potable Drinking Water	Ready to Use solution

59055-1	Metering Pump

1 mg/ liter (1ppm) or less

1 gallon per 100,000 gallons of treated water	1 mg/ liter (1ppm) or less

1 gallon per 100,000 gallons of treated water	None Stated

	9150-2, 9150-3

9804-1

9804-5, 9150-9	None stated	5 ppm	None stated

Water Storage systems aboard Aircraft Boats, RV’s Off-shore Oil Rigs
Soluble concentrate

9150-2, 9150-3

9804-1	Add to tank and lines	50 to 500 ppm available chlorine dioxide
None stated

Municipal Well Waters	9150-2, 9150-3	None stated	1 ppm	None stated

Commercial water filtration systems	9804-1	Add to system	300 ppm	None
Stated

Commercial, institutional and industrial premises and equipment

Dental Offices

Dental Pumice Disinfectant	Soluble Concentrate

9150-3

9804-1	Apply to Dry Pumice	500 ppm	Discard 5 days after preparation

Hospitals and Nursing Homes

Institutions and Public Places

 General disinfectant	Soluble Concentrate

10589-3,

9150-11

9804-1

	Spray	1000 ppm to 1406 ppm (mixed with DDAC)	Remove gross filth and
heavy soil prior to application of the disinfecting solution

Hospitals, Laboratories and Institutions

Hard Non Porous surfaces (Tile Floors, Walls and Ceilings and Stainless
Steel Cold Rooms)	Soluble Concentrate

9150-2, 9150-3

9804-1	Spray, Mop or sponge	Working Solution containing 300 to 500 ppm
available Chlorine Dioxide	Clean all surfaces with a suitable detergent
and rinse with water prior to disinfection.

Disinfection of Bench Tops, Biological Hoods, Incubators, Stainless
Steel Equipment and Instruments	Soluble Concentrate

9150-2, 9150-3

9804-1	Squirt onto surfaces with squeeze bottle	Working Solution
containing 300 to 500 ppm available Chlorine Dioxide	Clean all surfaces
with a suitable detergent and rinse with water prior to disinfection.

Water Bath Incubator	Soluble Concentrate

9150-2, 9150-3

9804-1	Pour solution into waterbath reservoir	Working Solution
containing 300 ppm available Chlorine Dioxide to disinfect

50 ppm for order and slime control	Clean reservoir with a suitable
detergent and rinse with water prior to disinfection

Sterilzation of Spent Biologicals in Steam Autoclaves	Soluble
Concentrate

9150-2, 9150-3	Spray or pour directly into autoclave buckets	Working
Solution containing 1,000 ppm available Chlorine Dioxide	None Stated

To Deodorize Animal Holding Rooms, Sick Rooms, Morgues and Work rooms
Soluble Concentrate

9150-2, 9150-3

9804-1	Spray solution on to walls ceilings and floors	Working Solution
containing 1,000 ppm available Chlorine Dioxide	Rooms to deodorize
should be ina clean condition prior to autoclaving.

Industrial Processing Plants	Soluble Concentrate

10589-3

	Spray	5 oz. per gallon/ 1406 ppm	Remove gross filth and heavy soil
prior to application of the disinfecting solution

Deodorizer- Hospitals, Restaurants, Hotel & Motel Rooms	Ready-to Use

9804-3	Spray	Spray area until covered with mist and let stand for 10
minutes	None stated

Swimming Pools

Swimming Pools	Ready to use solution

59055-1	Meetering Pump	1 to 5ppm  at a pH range from 7.2-7.6	None Stated

Residential and Public Access

Odors on Pets, Litter Boxes, Carpets and Concrete Floors	Soluble
concentrate

9150-2, 9150-3

9804-1	Soak, Mop or rinse	For litter boxes: 625 – 650ppm

For carpets: 500 ppm

Concrete floors: 1250 ppm

Animal Baths: 80-100 ppm	Avoid direct contact with animal’s eyes, nose
and ears

Ice Fishing in the Round Treatment	Soluble Concentrate

9150-2, 9150-3

9804-1	None stated	20 ppm 	None stated

Deodorizer- Restrooms/Bathrooms, Refuse Containers, diaper Pails,
Storage Lockers	Ready-to Use

9804-3	Spray	Spray area until covered with mist and let stand for 10
minutes	None stated

Industrial Processes and Water Systems

Water Cooling systems	Ready to Use,

Soluble concentrate

59055-1

9804-9

9804-1	Batch load or meter	100 ppm

5.0 ppm	None Stated

Recirculating Cooling Water systems	Soluble concentrate,

Ready to use Solution

9150-2, 9150-3

9804-9	None stated	5-20 ppm	None stated

Water Based Cutting Oils	Soluble Concentrate 9150-2, 9150-3	Slug does
system	32 oz to 10 gallons per million gallons of cutting oil	None
stated

Paper Mills	Soluble Concentrate,

Ready to use Solution

9150-2, 9150-3

9804-9, 9804-1

	None stated	4.5 gallons product per 100 tons of paper

1.25 – 5.0 ppm (3.2 – 12.8 fluid ounces per 1,000 gallons of water
None stated

Oil Wells : Secondary Recovery Operations	Soluble Concentrate

9150-2, 9150-3	None Stated	5,000 ppm available chlorine dioxide	None
stated

Once Through Water Cooling Systems	Soluble Concentrate

9150-2, 9150-3	Slug and Continuous 	Slug Dose: 5-25 ppm

Continuous Dose: 0.25 to 2.0 ppm	None Stated

Ventilation systems	Soluble concentrate

9804-1	Spray or fog	500 ppm. 10 minute contact time	NIOSH/MSHA approved
respirator required

Appendix A - Sodium Chlorite 020502

Use Site	Formulation/ EPA Reg No.	Method of Application	Application
Rate/ No. of applications	Use Limitations

Agricultural premises and equipment

Mushroom Facilities: (food Contact) Stainless Steel Tanks, Transfer
Lines, On-line Equipment, Picking Baskets	Soluble Concentrate/ Ready to
Use Solution

5382-46

58300-17

74602-2	Flush equipment with sanitizing solution	Use-solution calls for
100 ppm total available chlorine dioxide	Clean equipment and surfaces
thoroughly using a suitable detergent and rinse with water before
sanitizing.

Mushroom Facilities (non-food contact): disinfect walls ceilings and
floors	Soluble Concentrate/ Ready to use Solution

5382-46

58300-17

69151-5

74602-2	Spraying device	500 ppm total available chlorine dioxide

1,000 ppm for control of mold and slime on walls	Remove all gross filth
from areas prior to disinfection. Never reuse activated solutions

Avoid contact with food or food contact surfaces.

Potato Facilities: (food Contact) Stainless Steel Tanks, Transfer Lines,
On-line Equipment, Handling equipment	Soluble concentrate:

53345-20, 56485-4	Fill, flush, immerse or spray	Use-solution calls for
100 ppm total available chlorine dioxide	None stated

Potato Facilities: potato rinse tanks, flumes and lines	Soluble
concentrate:

53345-20, 56485-4, 9150-7	Chemical Feed pump or injector system

	5 ppm	After Treatment Potatoes must be rinsed with potable water.

Potato Storage: Potato rinse and humidification water	Soluble
concentrate:

53345-20, 56485-4, 21164-21	Spray, mist and fogger	200 to 400 ppm 	No
more than 20 gallons of product concentrate per month to humidification
water per 500 tons of potatoes in storage.

Always use an applicable NIOSH/MSHA approved respirator appropriate for
chlorine dioxide.

Disinfection of Animal Confinement Facilities (Poultry Houses, Swine
farrowing pens, Calf Barns and Kennels	Soluble Concentrate

70060-18, 45631-23, 74602-2, 70060-6, 74602-3, 70060-19, 69151-5, 8714-8
Mop, sponge or Use Commercial Sprayer to saturate all surfaces	Working
Solution containing 300 to 500 ppm available Chlorine Dioxide	Remove all
animals and feed from premises. Remove all litter and manure from
premises of facilities. Empty all troughs , racks and other feeding
equipment/ watering appliances.

Thoroughly clean all surfaces with soap and detergent and rinse with
water.

Agricultural premises and equipment

Poultry House Disinfection:

Poultry Chiller Water/ Carcass spray	Soluble Concentrate

74602-2

9150-7

9150-8

74602-3

	Dip Carcass	0.11 to 0.33 ounces per gallon for Chiller Water or 50 to
150 ppm

500 to 1200 ppm for Carcass Spray	None stated

Poultry Processing Water	Soluble Concentrate, Ready to use Solution

21164-6

21164-8

21164-9

53345-19

53345-20

56485-4

74517-2

53345-21

74517-1

74119-1	None stated	3 ppm max	None stated

Poultry Drinking Water	Soluble Concentrate

74602-2	Add to water	5ppm for fouled water

0.5 to 1.0ppm for control	None stated

Poultry, swine, cattle and other livestock Drinking Water	Soluble
Concentrate

64449-1	Add to water	5ppm for fouled water

0.5 to 1.0ppm for control	None stated

Egg Room/  Hatching Area

Incubator Room

Tray Washing Room and Loading Platform	Soluble Concentrate

74602-2	High pressure sprayer	20 ppm for pre wash w/ sprayer

390 ppm to preclean floors

1,000 ppm treatment w/ fogger	None Stated

Egg Shells (Food Grade)	Soluble Concentrate

74602-2	Wet Thoroughly	5.0 ppm	Do not reuse solution

Chick Room, Chick Grading Box an Sexing room	Soluble Concentrate

74602-2	Fogger, Mop	1,000 ppm w/ fogger

390 ppm to mop floors	None Stated

Agricultural premises and equipment

Horticulture uses

Work Area and Benches

	Soluble Concentrate

70060-6	Cloth, mop, sponge or sprayer	100 ppm	Do not Apply directly to
Plant Material

Horticulture uses

Pots and Flats	Soluble Concentrate

70060-6	Soak	100 ppm	Remove all loose soil and plant residue prior to
application

Horticulture uses

Cutting Tools	Soluble Concentrate

70060-6	Soak	100 ppm	None Stated

Horticulture uses

Bulbs

Soak	9 to 18 fl oz per gallon/ 253 ppm to 506 ppm	None Stated

Horticulture uses

Greenhouse Glass, Walkways and under Bench Areas	Soluble Concentrate

70060-6

	Spray	33 to 100 ppm	None Stated

Evaporative Coolers	Soluble Concentrate

70060-6	Add to water	100 ppm	None Stated

Food handling/ Storage establishments premises and equipment

Non-Porous, Food Contact, hard surface sanitizer	Soluble concentrate:

74986-1, 70060-19, 21164-3, 21164-8, 21164-9, 5382-46	Foamer, Dilution
device or spray	5ppm of activated available chlorine dioxide	None stated

Food Processing Plants

(Poultry, Meat, Fish)

	Soluble Concentrate

74602-2, 21164-3	fogger	0.5 ppm	Ventilate for 15 minutes prior to
reentry

Food Processing Plants

(Poultry, Meat, Fish)

Food Contact Surface Sanitizer	Soluble concentrate:

Reg:53345-14

53345-19

53345-20

69151-3

70060-6

9150-7

	1 minute contact time	50ppm- 1,000 ppm total available chlorine Dioxide

	Preclean and rinse equipment. Do not reuse solution. Do not rinse
treated surface

Food handling/ Storage establishments premises and equipment

Fruit and Vegetables	Soluble Concentrate

9150-8	Spray or dip	500 to 1200 ppm	Rinse with potable water after
treatment.

Dairies, Breweries and Bottling Plants

	Soluble Concentrate

74602-2

74602-1	Fogger	0.5 ppm	Ventilate for 15 minutes prior to reentry

Dairies, Breweries and Bottling Plants

Food Contact Surface Sanitizer	Soluble concentrate:

53345-14

53345-19

53345-20

9150-7

9150-8

21164-6

21164-8

21164-9

74602-2

5382-46

74517-1

53345-21

73139-1

	1 minute contact time	50ppm- 1,000 ppm total available chlorine Dioxide

	Preclean and rinse equipment. Do not reuse solution. Do not rinse
treated surface

Lube Additive for Moving Conveyors and Chains	Soluble concentrate:
74602-3, 21164-3	Inject into distribution system

	10- 20 ppm	Preclean and sanitize all conveyor surfaces and associated
structures

Canning Retort and Pasteurizer Cooling Water	Soluble concentrate:
70060-6, 74602-2, 70060-16, 53345-14, 9150-7, 9150-8,  46207-5, 5382-46

	Controlled Chemical Feed Pump 	0.1-5ppm	None stated

Food handling/ Storage establishments premises and equipment

Stainless Steel Transfer Lines, Hydrocoolers and Pasteurizers	Soluble
concentrate:

70060-6, 74602-2, 5382-46	Mix and fill lines and Equipment overnight

	20 ppm 	Preclean equipment or line thoroughly

Process Water for Vegetable Rinses, Tanks Lines	70060-6, 5382-46
Chemical Feed Pump or injector system

	5 ppm	Preclean all tanks, flumes and lines with suitable detergent.

Fruit and Vegetable Rinse	Soluble concentrate:

45631-22, 45631-20, 74602-2, 45631-19, 53345-20, 56485-4, 45631-22,
69151-5, 9150-7, 9150-8, 21164-21, 45631-19, 5382-46

79814-3

	Immersion, spray	1/3 fl. to 1 gallon of water per 25 gallons of water

3-5 ppm	Prewash whole fruits and vegetables with clean potable water.

Ice Making Plants and Machinery

	Ready to use:

70060-13

	Hang or place the sachet in the ice chamber out of direct contact with
water or ice

	50 to 200 g sachet per 100 to 400 lbs per day	None stated

	Soluble concentrate: 5382-46	Chemical Feed Pump or Injector System

	20 ppm	None stated

Human Water Systems

Potable Drinking Water	Soluble concentrate:

53345-14

53345-19

53345-20

53345-22

69151-5

69151-3

70060-6

9150-7

9150-8

21164-6

21164-8

21164-9

21164-21

74602-2

5382-41

5382-42

5382-45

5382-46

74517-2

74517-1

53345-21

74602-1

79814-3

	Metering Pump

1 mg/ liter (1ppm) or less

1 gallon per 100,000 gallons of treated water	1 mg/ liter (1ppm) or less

1 gallon per 100,000 gallons of treated water	None Stated

None stated	5 ppm	None stated

	Ready to use:

70060-22

	Tablet	1 tablet per liter of water.  Four hour treatment time.	None
stated

Water Storage systems aboard Aircraft Boats, RV’s Off-shore Oil Rigs
Soluble concentrate:

74602-2

5382-46	Add to tank and lines	50 to 500 ppm available chlorine dioxide
None stated

Human Water Systems

Municipal Well Waters	Soluble concentrate:

53345-23

55050-1

55050-2

70060-6

46207-5

74602-2

5382-46

	None stated	1 ppm	None stated

Commercial, institutional and industrial premises and equipment

Non-Porous, Non-food Contact, hard surface sanitizer	Soluble
concentrate:

74986-1, 53345-13, 70060-19, 45631-15,

	Dilution device or sprayer	100 ppm-200 ppm

	Odors on Pets, Litter Boxes, Carpets and Concrete Floors	Soluble
concentrate:

70060-6, 70060-4	Soak, Mop or rinse	For litter boxes: 625 – 650ppm

For carpets: 500 ppm

Concrete floors: 1250 ppm

Animal Baths: 80-100 ppm

	Avoid direct contact with animal’s eyes, nose and ears

Residential

Bathroom surfaces, shower stalls, curtains, laundry rooms, hampers and
other non specified surfaces for mold and mildew control.	Soluble
concentrate

74602-2	Spray, fog, pour, wipe	Dilute 13 fl. oz. solution as needed

5 minutes surface contact	After 30 minutes rinse with water

De-oderizer pouches for Refrigerators, Shoes, Gym Basements, Lockers,
Laundry Hampers, Automobiles, Boat Cabins, athletic bags, trash cans
pet areas, etc.	Ready to use Solution , Impregnated Materials

9804-10

70060-12	Hang or place sachet (deodorizing pouch)	5 to 200 grams sachet
for use from 1 week to 2 months	None Stated.

Carpets	Ready to Use Powder

4822-512	Sprinkle on Carpet	2.5 oz per square yard.	Keep Children and
pets off treated areas during application and until area is vacuumed.

Medical premises and equipment

Hospitals, Laboratories and Institutions

Hard Non Porous surfaces (Tile floors, Walls and Ceilings and Stainless
Steel Cold Rooms)

	Soluble concentrate:

74602-2, 69151-1, 69151-5	Spray, Mop or sponge	Working Solution
containing 300 to 500 ppm available Chlorine Dioxide	Clean all surfaces
with a suitable detergent and rinse with water prior to disinfection.

Treatment of infectious medial waste (prior to disposal in a in a
conventional solid waste landfill)

	Soluble concentrate:

69972-1	Approved application system	None listed on label	None stated

Water Bath Incubator	Soluble concentrate:

74602-2, 70060-6	Pour solution into waterbath reservoir	Working Solution
containing 300 ppm available Chlorine Dioxide to disinfect

50 ppm for odor and slime control

	Clean reservoir with a suitable detergent and rinse with water prior to
disinfection

Sterilization of Spent Biologicals in Steam Autoclaves	Soluble
concentrate:

70060-6	Spray or pour directly into autoclave buckets

	Working Solution containing 1,000 ppm available Chlorine Dioxide	None
Stated

To Deodorize Animal Holding Rooms, Sick Rooms, Morgues and Work rooms
Soluble concentrate:

70060-6	Spray solution on to walls ceilings and floors	Working Solution
containing 1,000 ppm available Chlorine Dioxide	Rooms to deodorize
should be in a clean condition prior to autoclaving.

Swimming Pools

Swimming Pools	Tablet form, Ready to Use solution

70060-20	Tablet insert in hair and lint basket	1 tablet for  under
10,000 gallons

2 tablets for over 10,000 gallons

Apply every 3-4 weeks	Do not add this product through any automatic
dispensing device. Apply product when no persons are in the pool.

Industrial Processes and water systems

Waste water

	Soluble concentrate:

53345-20, 55050-1

55050-2

56485-4

69151-4

69151-3

9150-7

10707-32

21164-6

21164-8

21164-9

21164-21

46207-5

5382-41

5382-43

5382-45

74119-1

74517-3

74517-2

53345-10

79814-3

53345-12

5382-42

74602-1	Batch load or meter	5.0 ppm to 100 ppm

	None Stated

Industrial Processes and water systems

Water Cooling systems	Soluble concentrate:

53345-14

53345-19

53345-22

56485-4

69151-4

10707-32

46207-5

5382-46

	Batch load or meter	5.0 ppm to 100 ppm

	None stated

Industrial process water	Soluble concentrate:

53345-20

9150-7

21164-8

53345-21

74602-1	Batch load or meter	5.0 ppm to 100 ppm

	NIOSH/MSHA approved respirator required

Water Based Cutting Oils	Soluble concentrate:

70060-6	Slug does system	32 oz to 10 gallons per million gallons of
cutting oil	None stated

Oil Wells : Secondary Recovery Operations	Soluble concentrate:

69151-3

68329-18

70060-6

10707-32

21164-3

5382-41

74602-3

	None Stated	5,000 ppm available chlorine dioxide	None stated

Oilfield Injection 	Soluble concentrate:

74602-1

79814-3

	Shock dosage	200-3000ppm	None stated

Industrial Processes and water systems

Recirculating Cooling Towers	Soluble concentrate:

74062-1

79814-3	Cooling tower drip pan	0.1 to 5.0 ppm

55.3 fl. oz per 1000 gallons of water for initial dosage

2.6 fl. oz per 100 gallons of water for subsequent dosage	None Stated

Once Through Water Cooling Systems	Soluble concentrate:

53345-14

53345-19

53345-20

69151-3

70060-6

9150-7

9150-8

1757-96

5382-41

5382-43

5382-45

74119-1

74517-2

53345-21

74602-1

79814-3

	Slug and Continuous 	Slug Dose: 5-25 ppm

Continuous Dose: 0.25 to 2.0 ppm	None Stated

Paper Mills	Soluble concentrate:

53345-22

56485-4

69151-4

69151-3

70060-6

74602-1

9150-7

9150-8

10707-32

21164-6

21164-8

21164-9

21164-21	None stated	4.5 gallons product per 100 tons of paper

.01 – 5.0 ppm (3.2 – 12.8 fluid ounces per 1,000 gallons of water
None stated

Industrial Processes and water systems

Paper Mills	Soluble concentrate:

46207-5

5382-41

5382-42

5382-43

5382-45

74119-1

74517-2

53345-21

74655-2

	None stated	4.5 gallons product per 100 tons of paper

1.25 – 5.0 ppm (3.2 – 12.8 fluid ounces per 1,000 gallons of water
None stated

  SEQ CHAPTER \h \r 1 APPENDIX B:  Chlorine dioxide and Sodium
Chlorite* (Case 4023)

Appendix B lists the generic (not product specific) data requirements
which support the re-registration of Chlorine Dioxide and Sodium
Chlorite.  These requirements apply to Chlorine Dioxide and Sodium
Chlorite in all products, including data requirements for which a
technical grade active ingredient is the test substance.  The data table
is organized in the following formats:

1.	Data Requirement (Columns 1 and 2).  The data requirements are listed
by Guideline Number.  The first column lists the new Part 158 Guideline
numbers, and the second column lists the old Part 158 Guideline numbers.
Each Guideline Number has an associated test protocol set forth in the
Pesticide Assessment Guidance, which are available on the EPA website.

Guideline Description (Column 3). Identifies the guideline type.

3.	Use Pattern (Column 4).  This column indicates the standard
Antimicrobial Division use patterns categories for which the generic
(not product specific) data requirements apply. The number designations
are used in Appendix B.

	(1) Agricultural premises and equipment

	(2) Food handling/ storage establishments’ premises and equipment

	(3) Commercial, institutional and industrial premises and equipment

	(4) Residential and public access premises

	(5) Medical premises and equipment

	(6) Human water systems

	(7) Materials preservatives

	(8) Industrial processes and water systems

	(9) Antifouling coatings

	(10) Wood preservatives

	(11) Swimming pools

	(12) Aquatic areas

3.	Bibliographic Citation (Column 5).  If the Agency has data in its
files to support a specific generic Guideline requirement, this column
will identity each study by a “Master Record Identification (MRID)
number. The listed studies are considered “valid” and acceptable for
satisfying the Guideline requirement. Refer to the Bibliography appendix
for a complete citation of each study.

DATA REQUIREMENT	CITATION(S)

New Guideline Number	Old Guideline Number	Study Title	Use Pattern	MRID
Number

PRODUCT CHEMISTRY

830.1550	61-1	Product Identity and Composition	1-4, 5, 8, 11	41467601,
41467602

830.1600 830.1620

830.1650	61-2a	Starting Materials and Manufacturing Process	1-4, 5, 8,
11	41467601, 41467602

830.1670	61-2b	Formation of Impurities	1-4, 5, 8, 11	41467601, 41467602

830.1700	62-1	Preliminary Analysis	1-4,, 5, 8, 11	41467601, 41467602

830.1750	62-2	Certification of Limits	1-4, 5, 8, 11	41467601, 41467602

830.1800	62-3   	Analytical Method	1-4, 5, 8, 11	41467601, 41467602

830.6302	63-2	Color	1-4, 5, 8, 11

	41467601, 41467602

830.6303	63-3	Physical State	1-4, 5, 8, 11	41467601, 41467602

830.6304	63-4	Odor	1-4, 5, 8, 11	41467601, 41467602

830.7200	63-5	Melting Point	1-4, 5, 8, 11	41467601, 41467602

830.7220	63-6	Boiling Point	1-4, 5, 8, 11	41467601, 41467602

830.7300	63-7	Density	1-4, 5, 8, 11	41467601, 41467602

830.7840

830.7860	63-8	Solubility	1-4, 5, 8, 11	41467601, 41467602

830.7950	63-9	Vapor Pressure	1-4, 5, 8, 11	41467601, 41467602

830.7550

830.7560

830.7570	63-11	Partition Coefficient (Octanol/Water)	1,4, 5, 8, 11
41467601, 41467602

830.7000	63-12	pH	1-4, 5, 8, 11	41467601, 41467602

830.6313	63-13	Stability	1-4, 5, 8, 11	41467601, 41467602

830.6314	63-14	Oxidizing/Reducing Action	1-4, 5, 8, 11	41467601,
41467602

830.6315	63-15	Flammability	1-4, 5, 8, 11	41467601, 41467602

830.6316	63-16	Explodability	1-4, 5, 8, 11	41467601, 41467602

830.6317	63-17	Storage Stability	1-4, 5, 8, 11	41467601, 41467602

830.6319	63-19   	Miscibility	1-4, 5, 8, 11	41467601, 41467602

ECOLOGICAL EFFECTS

850.1300	72-4	Fish early life-stage testing-freshwater

Data gap

850.1400	72-4b	Invertebrate life-cycle testing - freshwater

Data gap

850.4225	123-1	Seedling emergence dose-response in rice

Data gap

850.4250	123-1	Vegetative vigor dose-response in rice

Data gap

850.4400	123-2	Aquatic vascular plant dose-response toxicity- Lemna sp.

Data gap

850.5400	123-2	Acute algal dose-response toxicity - 4 species

Data gap (only one species tested-MRID 41880403)

850.2100	71-1	Avian Acute Oral Toxicity Test (Quail/Duck)

ACC259373,ACC257341, ACC253378, MRID 31610, ACC254177, ACC252854

850.1075	72-1	Fish Acute Toxicity – Freshwater (Rainbow Trout)

MRID94068007, ACC254181, ACC254180, ACC252854, ACC245697, ACC69810,
ACC253379, MRID94068006

850.1010	72-2	Acute Aquatic Invertebrate Toxicity

MRID146162, MRID141149, MRID131350, ACC254182, MRID94068009

TOXICOLOGY*

870.1100	81-1	Acute Oral - Rat

MRID 43558601

870.1200	81-2	Acute Dermal - Rabbit

MRID 40168704

870.1300	81-3	Acute Inhalation - Rat

MRID 42484101

870.2400	81-4	Primary Eye Irritation - Rabbit

MRID 43441903

870.2500	81-5	Primary Dermal Irritation - Rabbit

MRID40168704

870.2600	81-6	Dermal Sensitization

Data gap

870.3100	82-1a	90-Day Oral (gavage) -Rat

MRID 42301601

870.3465	82-4	28/90-Day Inhalation - Rat

Open literature

870.3700	83-3	Developmental Toxicity -Rat

Open literature

870.3700	83-3	Developmental Toxicity - Rabbit

MRID 41715701

870.3800	83-4	Two-generation Reproduction - Rat

MRID 45358901

870.5265	84-2	Bacterial Reverse Mutation Assay

Open literature

870.5300	84-2	Detection of gene mutations in somatic cells

ACC265867

870.5385	84-2	Micronucleus Assay

Open literature

870.4200	83-2	Carcinogenicity

Data gap

* Databases for chlorine dioxide and sodium chlorite were used
interchangeably.

Appendix C.  Technical Support Documents  XE "VI. Appendices:C.
Technical Support Documents"

	Additional documentation in support of this RED is maintained in the
OPP docket located in Room S-4400, One Potomac Yard (South Building),
2777 S. Crystal Drive, Arlington, VA 22202, and is open Monday through
Friday, excluding Federal holidays, from 8:30 a.m. to 4:00 p.m.

	The docket initially contained the draft risk assessments and related
documents as of April 28, 2004.  Sixty days later the first public
comment period closed.  The EPA then considered all comments and revised
the risk assessments.

	All documents, in hard copy form, may be viewed in the OPP docket room
or downloaded or viewed via the Internet at the following site:
HYPERLINK "http://www.regulations.gov"  http://www.regulations.gov ,
docket ID # EPA-HQ-OPP-2006-0328.

	These documents include:

Chlorine Dioxide Draft Risk Assessment, 4/6/2006.

Chlorine Dioxide Toxicology Disciplinary Chapter, 4/5/2006.

Chlorine Dioxide Occupational and Residential Exposure Assessment,
4/5/2006.

Chlorine Dioxide Environmental Fate and Transport Assessment, 4/5/2006.

Chlorine Dioxide Product Chemistry Chapter, 4/5/2006.

Chlorine Dioxide Dietary Exposure Assessment, 4/6/2006.

Chlorine Dioxide Environmental Hazard and Risk Assessment, 4/6/2006.

Chlorine Dioxide Incident Reports, 2/23/2006.

Chlorine Dioxide Environmental Modeling Chapter, 6/28/2005.

Appendix D.	Citations Considered to be Part of the Data Base Supporting
the Reregistration Decision (Bibliography)  XE "VI. Appendices:D.
Bibliography Citations"

GUIDE TO APPENDIX D

1.	CONTENTS OF BIBLIOGRAPHY.  This bibliography contains citations of
all studies considered relevant by EPA in arriving at the positions and
conclusions stated elsewhere in the Chlorine Dioxide Reregistration
Eligibility Document.  Primary sources for studies in this bibliography
have been the body of data submitted to EPA and its predecessor agencies
in support of past regulatory decisions.  Selections from other sources
including the published literature, in those instances where they have
been considered, are included.

2.	UNITS OF ENTRY.  The unit of entry in this bibliography is called a
“study.”  In the case of published materials, this corresponds
closely to an article.  In the case of unpublished materials submitted
to the Agency, the Agency has sought to identify documents at a level
parallel to the published article from within the typically larger
volumes in which they were submitted.  The resulting “studies”
generally have a distinct title (or at least a single subject), can
stand alone for purposes of review and can be described with a
conventional bibliographic citation.  The Agency has also attempted to
unite basic documents and commentaries upon them, treating them as a
single study.

3.	IDENTIFICATION OF ENTRIES.  The entries in this bibliography are
sorted numerically by Master Record Identifier, or “MRID” number.
This number is unique to the citation, and should be used whenever a
specific reference is required.  It is not related to the six-digit
“Accession Number” which has been used to identify volumes of
submitted studies (see paragraph 4(d)(4) below for further explanation).
 In a few cases, entries added to the bibliography late in the review
may be preceded by a nine character temporary identifier.  These entries
are listed after all MRID entries.  This temporary identifying number is
also to be used whenever specific reference is needed.

4.	FORM OF ENTRY.  In addition to the Master Record Identifier (MRID),
each entry consists of a citation containing standard elements followed,
in the case of material submitted to EPA, by a description of the
earliest known submission.  Bibliographic conventions used reflect the
standard of the American National Standards Institute (ANSI), expanded
to provide for certain special needs.

a.	Author.  Whenever the author could confidently be identified, the
Agency has chosen to show a personal author.  When no individual was
identified, the Agency has shown an identifiable laboratory or testing
facility as the author.  When no author or laboratory could be
identified, the Agency has shown the first submitter as the author.

b.	Document date.  The date of the study is taken directly from the
document.  When the date is followed by a question mark, the
bibliographer has deduced the date from the evidence contained in the
document.  When the date appears as (1999), the Agency was unable to
determine or estimate the date of the document.

c.	Title.  In some cases, it has been necessary for the Agency
bibliographers to create or enhance a document title.  Any such
editorial insertions are contained between square brackets.

d.	Trailing parentheses.  For studies submitted to the Agency in the
past, the trailing parentheses include (in addition to any
self-explanatory text) the following elements describing the earliest
known submission:

(1)	Submission date.  The date of the earliest known submission appears
immediately following the word “received.”

(2)	Administrative number.  The next element immediately following the
word “under” is the registration number, experimental use permit
number, petition number, or other administrative number associated with
the earliest known submission.

(3)	Submitter.  The third element is the submitter.  When authorship is
defaulted to the submitter, this element is omitted.

(4)	Volume Identification (Accession Numbers).  The final element in the
trailing parentheses identifies the EPA accession number of the volume
in which the original submission of the study appears.  The six-digit
accession number follows the symbol “CDL,” which stands for
“Company Data Library.”  This accession number is in turn followed
by an alphabetic suffix which shows the relative position of the study
within the volume.

MRID Studies

MRID #		Citation

31610	Fletcher, D. 1973.  Acute Oral Toxicity Study with Sodium Chlorite
in Bobwhite Quail.  Unpublished Data.  Conducted by Industrial BIO-TEST
Laboratories, Inc. for Olin Corporation.

69809	1978.  Acute Toxicity of Sodium Chlorite to Bluegill (Lepomis
macrochirus).  Unpublished Data.  Conducted by EG&G, Bionomics, Aquatic
Toxicology Laboratory for Olin Chemicals.

69810	1979.  Acute Toxicity of Sodium Chlorite to Rainbow Trout (Salmo
gairdneri).  Unpublished Data.  Conducted by EG&G, Bionomics, Aquatic
Toxicology Laboratory for Olin Chemicals.

80194	Sousa, J.V.  1981.  Acute Toxicity of Sodium Chlorite to
Bluegill(Lepomis macrochirus).  Unpublished Data.  Conducted by EG&G,
Bionomics for Olin Chemicals.

118007  	Sousa, J.V. and D.C. Surprenant.  1984.  Acute Toxicity of
AC-66 to Rainbow Trout (Salmo gairdneri).  Unpublished Data.  Conducted
by Springborn Bionomics, Inc. for Calgon Corporation.

130649  	Fink, R.  1977.  Eight-day Dietary LC50 - Bobwhite Quail –
Sodium Chlorite.  Unpublished Data.  Conducted by Wildlife
International, Ltd. for Olin Corporation.

130650 	Fink, R.  1977.  Eight-day Dietary LC50 – Mallard Duck –
Sodium Chlorite.  Unpublished Data.  Conducted by Wildlife
International, Ltd. for Olin Corporation.

131350	Vilkas, A.G.  1976.  Acute Toxicity of Textone to the Water Flea
Daphnia magna Strauss.  Unpublished Data.  Conducted by Aquatic
Environmental Sciences for Olin Corporation.

131351	Sleight III, B.H.  1971.  Acute Toxicity of Sodium Chlorite to
Bluegill (Lepomis macrochirus) and Rainbow Trout (Salmo gairdneri).
Unpublished Data.  Conducted by Bionomics, Inc.

141149	Hoberg, J.R. and D.C. Surprenant.  1984.  Acute Toxicity of AC-66
to Daphnids (Daphnia magna).  Unpublished Data.  Conducted by Springborn
Bionomics, Inc. for Calgon Corporation.

141151	Fletcher, D.  1984.  8-Day Dietary LC50 Study with Sodium
Chlorite in Bobwhite Quail.  Unpublished Data.  Conducted by Bio-Life
Associates, Ltd. for Calgon Corporation.

141152	Fletcher, D.  1984.  Acute Oral Toxicity Study with Sodium
Chlorite in Bobwhite Quail.  Unpublished Data.  Conducted by Bio-Life
Associates, Ltd. for Calgon Corporation.

142327  	McMillen, C.  1984.  Static Bioassay on Sodium Chlorite to
Rainbow Trout and Bluegill Sunfish.  Unpublished Data.  Conducted by
Environmental Research Group, Inc. for Rio Linda Chemical Company, Inc.

143970	Fletcher, D.  1984.  8-Day Dietary LC50 Study with Sodium
Chlorite in Mallard Ducklings.  Unpublished Data.  Conducted by Bio-Life
Associates, Ltd. for Calgon Corporation.

144730	Robaidek and Johnson, 1985. Avian Single-dose Oral LD50: Bob
White Quail (Colinus virginianus).  Unpublished Data.   Conducted by
Hazleton Laboratories America, Inc. for Rio Linda Chemical Company.

145405 	Beavers, 1984.  An Acute Oral Toxicity Study in the Mallard with
Sodium Chlorite.  Unpublished Data.  Conducted by Wildlife
International, Ltd. for TR America Chemicals, Inc.

145406 	Beavers, 1984.  An Acute Oral Toxicity Study in the Bobwhite
with Sodium Chlorite.  Unpublished Data.  Conducted by Wildlife
International, Ltd. for TR America Chemicals, Inc.

145407  	Beavers, 1984.  A Dietary LC50 Study in the Mallard Duck with
Sodium Chlorite.  Unpublished Data.  Conducted by Wildlife
International, Ltd. for TR America Chemicals, Inc.

145408 	Beavers, 1984.  A Dietary LC50 Study in the Bobwhite with Sodium
Chlorite.  Unpublished Data.  Conducted by Wildlife International, Ltd.
for TR America Chemicals, Inc.

145409  	Larkin, J.  1984.  The Acute Toxicity of Sodium Chlorite to
Rainbow Trout (Salmo gairdneri).  Unpublished Data.  Conducted by
Biospherics Incorporated for TR America Chemicals, Inc.

145510	Larkin, J.  1984.  The Acute Toxicity of Sodium Chlorite to
Bluegill Sunfish (Lepomis macrochirus).  Unpublished Data.  Conducted by
Biospherics Incorporated for TR America Chemicals, Inc.

145411	Larkin, J.  1984.  Acute Toxicity of Sodium Chlorite to Daphnia
magna Strauss.  Unpublished Data.  Conducted by Biospherics Incorporated
for TR America Chemicals, Inc.

146162	Barrows, 1984.  The Acute Toxicity of Sodium Chlorite Technical
to the Water Flea, Daphnia magna in a Static Test System.  Unpublished
Data.  Conducted by Biospherics Incorporated for Degussa Corporation.

148727  	Robaidek, E.  1985.  Avian Single-Dose Oral LD50 Bobwhite
Quail.  Unpublished Data.  Conducted by Hazleton Laboratories America,
Inc. for Degussa Corporation.

161875	1984.  96-Hour LC50 in Juvenile Rainbow Trout.  Unpublished Data.
 Conducted by Microbiological and Biochemical Assay Laboratories for
Magna Corporation.

161876	1984.  48-Hour LC50 in Daphnia magna.  Unpublished Data.
Conducted by Microbiological and Biochemical Assay Laboratories for
Magna Corporation.

161877  	1984.  Avian Dietary LC50 in Bob White Quail.  Unpublished
Data.  Conducted by Microbiological and Biochemical Assay Laboratories
for Magna Corporation.

161878	1983.  Avian Dietary LC50 in Mallard Ducks.  Unpublished Data.
Conducted by Microbiological and Biochemical Assay Laboratories for
Magna Corporation.

161879	1984.  Avian Single-Dose Oral LD50 in Bobwhite Quail.
Unpublished Data.  Conducted by Microbiological and Biochemical Assay
Laboratories for Magna Corporation.

164863	Cifone, M. 1994.  Mutagenicity Evaluation of Chlorine Dioxide in
the Mouse Lymphoma Foreword Mutation Assay.  Litton Bionetics,
Kensington, MD, LBI Project No. 20989, March 1984.

40168704  	1985.  Acute Dermal LD50 on Rabbit – Sodium Chlorite
Powder, Lot #110984-15.  Gibraltar Biological Lab, Inc. (Fairfield, NJ),
Internaltional Dioxcide, Inc. Study Number GBL 024065, April 23, 1985.

41715701	Irvine, Lorraine F.  Sodium Chlorite:  Rabbit Teratology Study
(Drinking Water Administration).  Toxicol. Labs, Ltd., Ledbury, UK,
Study Number CMA/3/R, September 21, 1990.

41843101  	Backus, P., K.E. Crosby and L.J. Powers.  1990.  Effect of
Sodium Chlorite on Vegetative Vigor of Plants (Tier I).  Unpublished
Data.  Conducted by Ricerca, Inc. for the Sodium Chlorite Reregistration
Task Force.

41843102  	Backus, P., K.E. Crosby and L.J. Powers.  1990.  Effect of
Sodium Chlorite on Seed Germination/Seedling Emergence (Tier I).
Unpublished Data.  Conducted by Ricerca, Inc. for the Sodium Chlorite
Reregistration Task Force.

41880403 	Ward, T.J. and R.L. Boeri.  1991.  Static Acute Toxicity of
Sodium Chlorite to the Freshwater Alga, Selenastrum capricornutum.
Unpublished Data.  Conducted by EnviroSystems Division, Resource
Analysis, Inc. for the Sodium Chlorite Reregistration Task Force.

41919701 	Rat Acute Oral Toxicity:  Oxine – New Powerful Bacteriostat
and Sanitizer.  Stillmeadow, Inc., Houston, TX, Lab. Project No.
3347-84, August 3, 1984.

41919702 	Rat Acute Dermal Toxicity:  Oxine – New Powerful
Bacteriostat and Sanitizer.  Stillmeadow, Inc., Houston, TX, Lab.
Project No. 3348-84, July 11, 1984.

41919703	 Rat Acute Inhalation Toxicity:  Oxine
–Bacteriostat/Deodorizer (AKA Purogene).  Stillmeadow, Inc., Houston,
TX, Lab. Project No. 4777-87, June 10, 1987.

41919704 	Rabbit Eye Acute Irritation:  Oxine- New Powerful Bacteriostat
and Sanitizer.  Stillmeadow, Inc., Houston, TX, Lab. Project No.
3349-84, June 26, 1984.

41919705 	Rabbit Skin Irritation:  Oxine – New Powerful Bacteriostat
and Sanitizer.  Stillmeadow, Inc., Houston, TX, Lab. Project No.
3350-84, June 26, 1984.

42301601 	Ridgway, P.(1992) 13 Week Oral(Gavage) Toxicity Study in the
Rat: Lab Project Number:CMA/13/R:CD-6.0-Tox.Unpublished study prepared
by Toxicol Labs Ltd for the CMA/Chlorine Dioxide Panel.329p.

42587501  	Popendorf, W.; Selim, M.; Kross, B. 1992. Chemical
Manufacturers Association Antimicrobial Exposure Assessment Study:
Second Replacement to MRID 41761201: Lab Project Number: Q626.
Unpublished study prepared by The University of Iowa.

42484101	Acute Inhalation Toxicity Evaluation in Rats.  International
Research and Development Corporation (IRDC), Mattawan, MI.  Lab. Project
No. 632-001, August 14, 1992.

43259401	Yurk, J.J. and M.A. Overman.  1994.  Acute Toxicity of Sodium
Chlorite to the Sheepshead Minnow (Cyprinodon variegatus).  Conducted by
Environmental Science & Engineering, Inc. for the Chemical Manufacturers
Association.

43259402 	Yurk, J.J. and M.A. Overman.  1994.  Acute Toxicity of Sodium
Chlorite to Mysid Shrimp.  Conducted by Environmental Science &
Engineering, Inc. for the Chemical Manufacturers Association.

43259403 	Yurk, J.J. and M.A. Overman.  1994.  Effect of Sodium Chlorite
on New Shell Growth in Eastern Oyster (Crassostrea virginica).
Conducted by Environmental Science & Engineering, Inc. for the Chemical
Manufacturers Association.

43441901 	Acute Oral Toxicity Study in Rats.  Stillmeadow, Inc., Sugar
Land, TX, Lab. Project No. 1439-94, October 26, 1994.

43441902 	Acute Dermal Toxicity Study in Rabbits.  Stillmeadow, Inc.,
Sugar Land, TX, Lab. Project No. 1440-94, October 10, 1994.

43441903  	Primary Eye Irritation Study in Rabbits.  Stillmeadow, Inc.,
Sugar Land, TX, Lab. Project No. 1441-94, October 11, 1994.

43503201 	Irritant Effects of Duozon 100-1 As a concentration of 0.3 ppm
relating to chlorine dioxide (CLO2) on rabbit skin.  Pharmatox,
Landkreis, Hannover, Germany, Lab. Project No. Not Available, July, 1994

43558601	Abdel-Rahman, et al., “Toxicity of Alcide,” published in J.
Appl. Toxicol. 2(3): 160-164, 1982.

43558602 	Dalhamn, T., “Chlorine Dioxide:  Toxicity in Animal
Experiments and Industrial Risks,” published in A.M.A. Arch. Indust.
Hlth. 15(2): 101-107, 1957.

45358901	Bailey, G. (1996) Sodium Chlorite: Drinking Water Rat
Two--Generation Reproductive Toxicity Study: Amended Final Report: Lab
Project Number: CMA/17/R. Unpublished study prepared by Quintiles
England Ltd. 2120 p

46919601 	Kennedy, J. (2002) Investigation of Potential Chemical
Exposure From HVAC Duct Sanitation Using Chlorine Dioxide Based Produce
Oxine (AD): Final Study Report. Project Number: BCI/0001. Unpublished
study prepared by Bio-Cide International Inc. 19 p.

46919602 	Harrington, R. (2002) Toxicological Assessment of Oxine During
In-Home HVAC Treatment: Final Study Report. Project Number: BCI 0002.
Unpublished study prepared by Bio-Cide International Inc. 29 p.

94068005	Johnson, G.  1984.  Avian Dietary LC50 Bobwhite Quail (Colinus
virginianus).  Unpublished Data.  Conducted by Hazleton Laboratories
America, Inc. for Degussa Corporation.

94068006 	Sousa and Surprenant, 1984.  Acute Toxicity of A-66 (Technical
Sodium Chlorite) to Bluegill (Lepomis macrochirus).  Unpublished Data.
Conducted by Springborn Binomics, Inc for Calgon Corporation.

94068007 	Barrows, B. 1984.  The Acute Toxicity of Sodium Chlorite
Technical to the Rainbow Trout, Salmo gairdneri, in a Static Test
System.  Unpublished Data.  Conducted by Biospherics Incorporated for
Degussa Corporation.

94068008.	Johnson, G.  1984.  Avian Dietary LC50 Mallard Duck (Anas
platyrhynchos).  Unpublished Data.  Conducted by Hazleton Laboratories
America, Inc. for Degussa Corporation.

94068009	Nachrord, S.  1984.  Daphnia LC50 Bioassay.  Unpublished Data.
Conducted by Anater Tesconi Circle for Rio Linda Chemical Company, Inc.

Accession Studies

Accession #		Citation

252854  	1983.  96-Hour LC50 in Bluegill Perch.  Unpublished Data.
Conducted by Microbiological and Biochemical Assay Laboratories for
Magna Corporation.

Open Literature

Citation

Dalhamn, T. (1957): Chlorine Dioxide: Toxicity in Animal Experiments and
Industrial Risks. Arch. Ind. Health 15: 101-107.

Daniel, F.B., et al. (1990): Comparative subchronic toxicity studies of
three disinfectants.  J Am Water Works Assoc 82:61-69.

Haag, H.B. (1949): The effect on rats of chronic administration of
sodium chlorite and chlorine dioxide in the drinking water.  Report to
the Mathieson Alkali Works from H.B. Haag of the Medical College of
Virginia.  February 7, 1949.

Harrington, R.M., et al. (1995a): Subchronic toxicity of sodium chlorite
in the rat.  J Am Coll Toxicol 14:21-33.

Harrington, R.M., et al. (1995b) Developmental toxicity of sodium
chlorite in the rabbit.  J Am Coll Toxicol 14:109-118.

Kurokawa, Y., et al. (1984): Studies on the promoting and complete
carcinogenic activities of some oxidizing chemicals in skin
carcinogenesis.  Cancer Lett 24:299-304.

Meier, J.R., et al. (1985): Evaluation of chemicals used for drinking
water disinfection for production of chromosomal damage and sperm-head
abnormalities in mice.  Environ Mutagen 7:201-211.

Miller, R.G., et al. (1986): Results of toxicological testing of
Jefferson Parish pilot plant samples.  Environ Health Perspect
69:129-139.

Mobley, S.A., et al. (1990): Chlorine dioxide depresses T3 uptake and
delays development of locomotor activity in young rats. In: Jolley, RL,
et al., eds. Water chlorination: chemistry, environmental impact and
health effects, vol. 6. Chelsea, MI: Lewis Publications, pp. 347-358.

Moore, G.S. and E.J. Calabrese (1982): Toxicological effects of chlorite
in the mouse.  Environ Health Perspect 46:31-37.

Orme, J., et al. (1985): Effects of chlorine dioxide on thyroid function
in neonatal rats. J Toxicol Environ Health 15:315-322.

Paulet G and S. Desbrousses (1970): On the action of ClO2 at low
concentrations on laboratory animals.  Arch Mal Prof 31:97-106.

Paulet G and S. Desbrousses (1972): On the toxicology of chlorine
dioxide.  Arch Mal Prof 33:59-61.

Paulet G and S. Desbrousses (1974): Action of a discontinuous exposure
to chlorine dioxide (ClO2) on the rat.  Arch Mal Prof 35:797-804.

Robinson, M; Bull, RJ; Schmaer, M; Long, RF. (1986) Epidermal
hyperplasia in the mouse skin following treatment with alternate
drinking water disinfectants. Environ Health Perspect 69:293-300.

Website References

Citation

FDA, 2003a.  “Guidance For Industry: Preparation of Food Contact
Notifications and Food Additive Petitions for Food Contact Substances:
Chemistry Recommendations.  Final Guidance.”  US Food and Drug
Administration.  April, 2003.   HYPERLINK
http://www.cfsan.fda.gov/~dms/opa2pmnc.html.
http://www.cfsan.fda.gov/~dms/opa2pmnc.html.   Last accessed June 9,
2003.

FDA, 2003b.  “Sanitizing Solutions:	Chemistry Guidelines for Food
Additive Petitions.”  US Food and Drug Administration.  January, 1993.
   HYPERLINK http://www.cfsan.fda.gov/~dms/opa-cg3a.html.
http://www.cfsan.fda.gov/~dms/opa-cg3a.html.   Last accessed June 9,
2003.

USEPA, 1999.  “Available Information on Assessing Exposure from
Pesticides, A User’s Guide.”   US Environmental Protection Agency,
Office of Pesticide Programs.  June 21, 1999.    HYPERLINK
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf.  Last
accessed June 9, 2003.

USEPA, 2001a.  “General Principles for Performing Aggregate Exposure
and Risk Assessments.” US Environmental Protection Agency, Office of
Pesticide Programs.  November 28, 2001.    HYPERLINK
http://www.epa.gov/pesticides/trac/science/aggregate.pdf.
http://www.epa.gov/pesticides/trac/science/aggregate.pdf.

USEPA, 2004. Overview of the Ecological Risk Assessment Process in the
Office of Pesticide Programs U.S. Environmental Protection Agency -
Endangered and Threatened Species Effects Determinations, Appendix A,
Section IIB, pg.81.  US Environmental Protection Agency.  January 24,
2004.
http://www.epa.gov/oppfead1/endanger/consultation/ecorisk-overview.pdf.

Other Supporting Documents

Citation

US EPA.  1997a.  Standard Operating Procedures (SOPs) for Residential
Exposure Assessments.  Contract No. 68-W6-0030.  Prepared by the
Residential Exposure Assessment Work Group.  Office of Pesticide
Programs, Health Effects Division and Versar.  July 1997.

US EPA.  1997b.  Exposure Factors Handbook.  National Center for
Environmental Assessment, Office of Research and Development.

US EPA.  1997c.  Surrogate Exposure Guide: Estimates of Worker Exposure
from the Pesticide Handler Exposure Database, Version 1.1.  May 1997.

US EPA.  2000.  Standard Operating Procedures (SOPs) for Residential
Exposure Assessments.  Office of Pesticide Programs, Health Effects
Division.  April 2000.

US EPA 2001b.  Review of a Health Risk Assessment for PHMB (Vantocil IB)
used on 100% Cotton Textile Application - Systemic Toxicity by an Infant
Sucking Textile.  Memorandum for Siroos Mostaghimi, Ph.D. to Adam
Heyward.  January 3, 2001.

Versar. 2003.  User's Manual Swimmer Exposure Assessment Model
(SWIMODEL) Version 3.0. Prepared for the US EPA Antimicrobials Division.
 November 2003.

Appendix E. Generic Data Call-In

The Agency intends to issue a Generic Data Call-In at a later date.  See
Chapter V of the Chlorine Dioxide RED for a list of studies that the
Agency plans to require.

  XE "VI. Appendices:E. Generic Data Call-In"

Appendix F. Product Specific Data Call-In

The Agency intends to issue a Product Specific Data Call-In at a later
date.

Appendix G.  Batching of Chlorine Dioxide and Sodium Chlorite Products
for Meeting Acute Toxicity Data Requirements for Reregistration

The Agency intends to complete batching at a later date.

Appendix H.  List of All Registrants Sent the Data Call-In

A list of registrants sent the data call-in will be posted at a later
date.

 Appendix I.  	List of Available Related Documents and Electronically
Available Forms  XE "VI. Appendices:I. List of Available Related
Documents and Electronically Available Forms"

Pesticide Registration Forms are available at the following EPA internet
site:

    HYPERLINK "http://www.epa.gov/opprd001/forms/"
http://www.epa.gov/opprd001/forms/ 	.

Pesticide Registration Forms (These forms are in PDF format and require
the Acrobat reader)

Instructions

1.	Print out and complete the forms.  (Note: Form numbers that are
bolded can be filled out on your computer then printed.)

2.	The completed form(s) should be submitted in hardcopy in accord with
the existing policy.

3.	Mail the forms, along with any additional documents necessary to
comply with EPA regulations covering your request, to the address below
for the Document Processing Desk.

DO NOT fax or e-mail any form containing ‘Confidential Business
Information’ or ‘Sensitive Information.’

If you have any problems accessing these forms, please contact Nicole
Williams at<PHONE_NUMBER> or by e-mail at   HYPERLINK
<EMAIL_ADDRESS><EMAIL_ADDRESS>.

The following Agency Pesticide Registration Forms are currently
available via the internet at the following locations:

8570-1	 Application for Pesticide Registration/Amendment	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-1.pdf"
http://www.epa.gov/opprd001/forms/8570-1.pdf

8570-4	Confidential Statement of Formula	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-4.pdf"
http://www.epa.gov/opprd001/forms/8570-4.pdf

8570-5	Notice of Supplemental Registration of Distribution of a
Registered Pesticide Product 	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-5.pdf"
http://www.epa.gov/opprd001/forms/8570-5.pdf

8570-17	 Application for an Experimental Use Permit	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-17.pdf"
http://www.epa.gov/opprd001/forms/8570-17.pdf

8570-25	 Application for/Notification of State Registration of a
Pesticide To Meet a Special Local Need 	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-25.pdf"
http://www.epa.gov/opprd001/forms/8570-25.pdf

8570-27	 Formulator’s Exemption Statement	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-27.pdf"
http://www.epa.gov/opprd001/forms/8570-27.pdf

8570-28	 Certification of Compliance with Data Gap Procedures
HYPERLINK "http://www.epa.gov/opprd001/forms/8570-28.pdf"
http://www.epa.gov/opprd001/forms/8570-28.pdf

8570-30	 Pesticide Registration Maintenance Fee Filing 	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-30.pdf"
http://www.epa.gov/opprd001/forms/8570-30.pdf

8570-32	 Certification of Attempt to Enter into an Agreement with other
Registrants for Development of Data 	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-32.pdf"
http://www.epa.gov/opprd001/forms/8570-32.pdf

8570-34	 Certification with Respect to Citations of Data (in PR Notice
98-5)	    HYPERLINK "http://www.epa.gov/opppmsd1/PR_Notices/pr98-5.pdf"
http://www.epa.gov/opppmsd1/PR_Notices/pr98-5.pdf

8570-35	Data Matrix  (in PR Notice 98-5)	    HYPERLINK
"http://www.epa.gov/opppmsd1/PR_Notices/pr98-5.pdf"
http://www.epa.gov/opppmsd1/PR_Notices/pr98-5.pdf

8570-36	Summary of the Physical/Chemical Properties  (in PR Notice 98-1)
    HYPERLINK "http://www.epa.gov/opppmsd1/PR_Notices/pr98-1.pdf"
http://www.epa.gov/opppmsd1/PR_Notices/pr98-1.pdf

8570-37	 Self-Certification Statement for the Physical/Chemical
Properties  (in PR Notice 98-1)	    HYPERLINK
"http://www.epa.gov/opppmsd1/PR_Notices/pr98-1.pdf"
http://www.epa.gov/opppmsd1/PR_Notices/pr98-1.pdf

Pesticide Registration Kit

    HYPERLINK "http://www.epa.gov"
www.epa.gov/pesticides/registrationkit/ .

Dear Registrant:

	For your convenience, we have assembled an online registration kit that
contains the following pertinent forms and information needed to
register a pesticide product with the U.S.  Environmental Protection
Agency’s Office of Pesticide Programs (OPP):

1.	The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and
the Federal Food, Drug and Cosmetic Act (FFDCA) as Amended by the Food
Quality Protection Act (FQPA) of 1996.

	2.	Pesticide Registration (PR) Notices

		a.	83-3 Label Improvement Program—Storage and Disposal Statements

		b.	84-1 Clarification of Label Improvement Program

		c.	86-5 Standard Format for Data Submitted under FIFRA

d.	87-1 Label Improvement Program for Pesticides Applied through
Irrigation Systems (Chemigation)

		e.	87-6 Inert Ingredients in Pesticide Products Policy Statement

f.	90-1 Inert Ingredients in Pesticide Products; Revised Policy
Statement

g.	95-2 Notifications, Non-notifications, and Minor Formulation
Amendments

h.	98-1 Self Certification of Product Chemistry Data with Attachments
(This document is in PDF format and requires the Acrobat reader.)

Other PR Notices can be found at     HYPERLINK
"http://www.epa.gov/opppmsd1/PR_Notices"
http://www.epa.gov/opppmsd1/PR_Notices .

3.	Pesticide Product Registration Application Forms (These forms are in
PDF format and will require the Acrobat reader.)

		a.	EPA Form No. 8570-1, Application for Pesticide
Registration/Amendment

		b.	EPA Form No. 8570-4, Confidential Statement of Formula

		c.	EPA Form No. 8570-27, Formulator’s Exemption Statement

		d.	EPA Form No. 8570-34, Certification with Respect to Citations of
Data

		e.	EPA Form No. 8570-35, Data Matrix

4.	General Pesticide Information (Some of these forms are in PDF format
and will require the Acrobat reader.)

		a.	Registration Division Personnel Contact List

b.	Biopesticides and Pollution Prevention Division (BPPD) Contacts

		c.	Antimicrobials Division Organizational Structure/Contact List

d.	53 F.R.  15952, Pesticide Registration Procedures; Pesticide Data
Requirements (PDF format)

e.  	40 CFR Part 156, Labeling Requirements for Pesticides and Devices
(PDF format)

		f.  	40 CFR Part 158, Data Requirements for Registration (PDF format)

g.  	50 F.R.  48833, Disclosure of Reviews of Pesticide Data (November
27, 1985)

Before submitting your application for registration, you may wish to
consult some additional sources of information.  These include:

	1.	The Office of Pesticide Programs’ Web Site

2.	The booklet “General Information on Applying for Registration of
Pesticides in the United States”, PB92-221811, available through the
National Technical Information Service (NTIS) at the following address:

			National Technical Information Service (NTIS)

			5285 Port Royal Road

			Springfield, VA 22161

The telephone number for NTIS is<PHONE_NUMBER>.  Please note that EPA
is currently in the process of updating this booklet to reflect the
changes in the registration program resulting from the passage of the
FQPA and the reorganization of the Office of Pesticide Programs.  We
anticipate that this publication will become available during the Fall
of 1998.

3.	The National Pesticide Information Retrieval System (NPIRS) of Purdue
University’s Center for Environmental and Regulatory Information
Systems.  This service does charge a fee for subscriptions and custom
searches.  You can contact NPIRS by telephone at<PHONE_NUMBER> or
through their Web site.

4.	The National Pesticide Telecommunications Network (NPTN) can provide
information on active ingredients, uses, toxicology, and chemistry of
pesticides.  You can contact NPTN by telephone at<PHONE_NUMBER> or
through their Web site:   HYPERLINK "http://npic.orst.edu"
http://npic.orst.edu  .

The Agency will return a notice of receipt of an application for
registration or amended registration, experimental use permit, or
amendment to a petition if the applicant or petitioner encloses with his
submission a stamped, self-addressed postcard.  The postcard must
contain the following entries to be completed by OPP:

			Date of receipt

			EPA identifying number

			Product Manager assignment

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搒Ý摧⻵±᐀he specific application submitted.  EPA will stamp the
date of receipt and provide the EPA identifying File Symbol or petition
number for the new submission.  The identifying number should be used
whenever you contact the Agency concerning an application for
registration, experimental use permit, or tolerance petition.

To assist us in ensuring that all data you have submitted for the
chemical are properly coded and assigned to your company, please include
a list of all synonyms, common and trade names, company experimental
codes, and other names which identify the chemical (including
“blind” codes used when a sample was submitted for testing by
commercial or academic facilities).  Please provide a CAS number if one
has been assigned.

 PAGE

 PAGE   57

		Chlorine Dioxide RED

  PAGE  102