1 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D. C. 20460 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES OCT 24 2003 NOTE TO FILE SUBJECT: Requirement for Acute Oral Toxicity Testing of Combination of Cry1Ab and Cry 3Bb1 Proteins for Yield gard Plus Corn TO: Mike Mendelsohn Regulatory Action Leader Microbial Pesticides Branch, Biopesticides and Pollution Prevention Division ( 7511C)

FROM: John L. Kough, Ph. D., Biologist Chris A. Wozniak, Ph. D., Plant Patholgoist Microbial Pesticides Branch, Biopesticides and Pollution Prevention Division ( 7511C)

DATA REVIEW RECORD Active Ingredient: Cry1Ab/ Cry3Bb1 proteins as expressed in maize Product Name: Event MON 810 x MON 863 traditional cross hybrid, Yieldgard Plus corn Company Name: Monsanto Corporation, 700 Chesterfield Pkwy, St. Louis, MO ID No: 000524 LUL Chemical Number: 006484 Submission Number: S627345 DP Barcode: D287601 BACKGROUND: Monsanto Corporation is seeking a registration to sell a corn product expressing two insecticidal proteins based on   endotoxins found in Bacillus thuringiensis species. Unlike some other products under consideration, the Monsanto Yieldgard Plus corn expresses   endotoxins aimed at controlling insect pests from two different orders, is supported by toxicity data for each protein generated by the company itself, has existing food tolerance exemptions in place and was developed through traditional hybrid cross plant breeding. 2 DISCUSSION: The presence of two or more newly expressed proteins in a genetically engineered plant is not expected to routinely require additional toxicity testing if there are existing data to demonstrate the safety of the individual proteins and a food tolerance determination has been made. This rationale is similar to that employed for the current products which often consist of both an expressed pesticidal protein and a marker gene protein expressed in a single plant. There may be instances where information available on the mode of action of the proteins would indicate the likelihood that the combination of proteins should be evaluated and the Agency reserves the right to test combinations in those instances.

RECOMMENDATION: The data generated for the Cry1Ab and Cry3Bb1 proteins individually can support a food tolerance determination for the combination since the mode of action for these proteins does not suggest an enhanced activity in combination for mammalian species. This lack of synergism is also suggested by the absence of enhanced responses in sensitive target species tested with the combination of Cry1Ab and Cry3Bb1proteins.


[Federal Register Volume 78, Number 111 (Monday, June 10, 2013)]
[Rules and Regulations]
[Page 34582]
[FR Doc No: 2013-13668]

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DEPARTMENT OF HOMELAND SECURITY

Coast Guard

33 CFR Part 165

[Docket No. USCG-2013-0346]

Safety Zone; Fourth of July Fireworks, City of Sausalito, San
Francisco Bay, Sausalito, CA

AGENCY: Coast Guard, DHS.

ACTION: Notice of enforcement of regulation.

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SUMMARY: The Coast Guard will enforce the safety zone for the Fourth of
July Fireworks, City of Sausalito in the Captain of the Port, San
Francisco area of responsibility during the dates and times noted
below. This action is necessary to protect life and property of the
maritime public from the hazards associated with the fireworks display.
During the enforcement period, unauthorized persons or vessels are
prohibited from entering into, transiting through, or anchoring in the
safety zone, unless authorized by the Patrol Commander (PATCOM).

DATES: The regulations will be enforced from 9 a.m. to 9:45 p.m. on
July 4, 2013.

FOR FURTHER INFORMATION CONTACT: If you have questions on this notice,
call or email Lieutenant Junior Grade William Hawn, U.S. Coast Guard
Sector San Francisco; telephone<PHONE_NUMBER> or email at<EMAIL_ADDRESS>
SUPPLEMENTARY INFORMATION: The Coast Guard will enforce a 100 foot
safety zone around the fireworks barge during the loading, transit, and
arrival of the fireworks barge to the display location and until the
start of the fireworks display. From 9 a.m. until 2 p.m. on July 4,
2013, the barge will be loading off of Pier 50 in approximate position
37[deg]46'28'' N, 122[deg]23'06'' W (NAD 83). From 7 p.m. to 8:30 p.m.
on July 4, 2013 the loaded barge will transit from Pier 50 to the
launch site near Sausalito, CA in approximate position 37[deg]51'31''
N, 122[deg]28'28'' W (NAD83). Upon the commencement of the 15 minute
fireworks display, scheduled to begin at 9:15 p.m. on July 4, 2013, the
safety zone will increase in size and encompass the navigable waters
around and under the fireworks barge within a radius 1,000 feet in
approximate position 37[deg]51'31'' N, 122[deg]28'28'' W (NAD83). In
accordance with 33 CFR 165.1191, Table 1, Item number 12, this safety
zone will be in effect from 9 a.m. to 9:45 p.m. on July 4, 2013.
    Under the provisions of 33 CFR 165.1191, unauthorized persons or
vessels are prohibited from entering into, transiting through, or
anchoring in the safety zone during all applicable effective dates and
times, unless authorized to do so by the PATCOM. Additionally, each
person who receives notice of a lawful order or direction issued by an
official patrol vessel shall obey the order or direction. The PATCOM is
empowered to forbid entry into and control the regulated area. The
PATCOM shall be designated by the Commander, Coast Guard Sector San
Francisco. The PATCOM may, upon request, allow the transit of
commercial vessels through regulated areas when it is safe to do so.
This notice is issued under authority of 33 CFR 165.1191 and 5 U.S.C.
552 (a). In addition to this notice in the Federal Register, the Coast
Guard will provide the maritime community with extensive advance
notification of the safety zone and its enforcement period via the
Local Notice to Mariners.
    If the Captain of the Port determines that the regulated area need
not be enforced for the full duration stated in this notice, a
Broadcast Notice to Mariners may be used to grant general permission to
enter the regulated area.

    Dated: May 18, 2013.
Gregory G. Stump,
Captain, U.S. Coast Guard, Captain of the Port San Francisco.
[FR Doc. 2013-13668 Filed 6-7-13; 8:45 am]
BILLING CODE 9110-04-P


[Federal Register Volume 81, Number 22 (Wednesday, February 3, 2016)]
[Notices]
[Page 5729]
[FR Doc No: 2016-01954]

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DEPARTMENT OF ENERGY

Federal Energy Regulatory Commission

[Docket No. EL16-34-000]

Electric Power Supply Association, Retail Energy Supply
Association, Dynegy Inc., Eastern Generation, LLC, NRG Power Marketing
LLC and GenOn Energy Management, LLC v. FirstEnergy Solutions
Corporation, Ohio Edison Company, The Cleveland Electric Illuminating
Company and The Toledo Edison Company; Notice of Complaint

    Take notice that on January 27, 2016, pursuant to sections 206, 306
and 309 of the Federal Power Act \1\ and Rule 206 of the Federal Energy
Regulatory Commission's (Commission) Rules of Practice and Procedure,
18 CFR 385.206 (2015), the Electric Power Supply Association, the
Retail Energy Supply Association, Dynegy Inc., Eastern Generation, LLC,
NRG Power Marketing LLC and GenOn Energy Management, LLC (Complainants)
filed a formal complaint against FirstEnergy Corporation's
subsidiaries, FirstEnergy Solutions Corporation, Ohio Edison Company,
The Cleveland Electric Illuminating Company and The Toledo Edison
Company (Respondents), alleging that an abusive affiliate power sales
contract involving subsidiaries of FirstEnergy Corporation may evade
Commission review, all as more fully explained in the complaint.
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    \1\ 16 U.S.C. 824e, 825e, 825h (2012).
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    Complainants certify that copies of the complaint were served on
the contacts for Respondents, as listed on the Commission's list of
Corporate Officials.
    Any person desiring to intervene or to protest this filing must
file in accordance with Rules 211 and 214 of the Commission's Rules of
Practice and Procedure (18 CFR 385.211 and 385.214). Protests will be
considered by the Commission in determining the appropriate action to
be taken, but will not serve to make protestants parties to the
proceeding. Any person wishing to become a party must file a notice of
intervention or motion to intervene, as appropriate. The Respondents'
answer and all interventions, or protests must be filed on or before
the comment date. The Respondents' answer, motions to intervene, and
protests must be served on Complainants.
    The Commission encourages electronic submission of protests and
interventions in lieu of paper using the ``eFiling'' link at http://www.ferc.gov. Persons unable to file electronically should submit an
original and 14 copies of the protest or intervention to the Federal
Energy Regulatory Commission, 888 First Street NE., Washington, DC
20426.
    This filing is accessible on-line at http://www.ferc.gov, using the
``eLibrary'' link and is available for review in the Commission's
Public Reference Room in Washington, DC. There is an ``eSubscription''
link on the Web site that enables subscribers to receive email
notification when a document is added to a subscribed docket(s). For
assistance with any FERC Online service, please email
<EMAIL_ADDRESS>or call<PHONE_NUMBER> (toll free). For
TTY, call<PHONE_NUMBER>.
    Comment Date: 5:00 p.m. Eastern Time on February 16, 2016.

    Dated: January 28, 2016.
Nathaniel J. Davis, Sr.,
Deputy Secretary.
[FR Doc. 2016-01954 Filed 2-2-16; 8:45 am]
 BILLING CODE 6717-01-P


[Federal Register Volume 85, Number 107 (Wednesday, June 3, 2020)]
[Notices]
[Page 34191]
[FR Doc No: 2020-11929]

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ENVIRONMENTAL PROTECTION AGENCY

[CERCLA-04-2020-2500; FRL-10007-80-Region 4]

Hydromex Superfund Site, Yazoo City, Mississippi Notice of
Settlement

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of settlement.

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SUMMARY: Under 122(h) of the Comprehensive Environmental Response,
Compensation and Liability Act (CERCLA), the United States
Environmental Protection Agency (EPA) has entered into an
Administrative Settlement Agreement and Order on Consent for Removal
Actions with potentially responsible parties (PRPs) concerning the
Hydromex Superfund Site located in Yazoo City, Mississippi. The
settlement is for the performance of a removal action.

DATES: The Agency will consider public comments on the settlement until
July 6, 2020. The Agency will consider all comments received and may
modify or withdraw its consent to the proposed settlement if comments
received disclose facts or considerations which indicate that the
proposed settlement is inappropriate, improper, or inadequate.

ADDRESSES: Copies of the settlement are available from the Agency by
contacting Ms. Paula V. Painter, Program Analyst, using information
within this notice or can be accessed on the Agency's web page https://www.epa.gov/aboutepa/about-epa-region-4-southeast#r4-public-notices.
Comments may be submitted by referencing the Site's name or Docket
#CERCLA-04-2020-2500 through email at<EMAIL_ADDRESS>
FOR FURTHER INFORMATION CONTACT: Paula V. Painter at 404/562-8887.

    Dated: April 14, 2020.
Maurice Horsey,
Chief, Enforcement Branch, Superfund & Emergency Management Division.
[FR Doc. 2020-11929 Filed 6-2-20; 8:45 am]
 BILLING CODE 6560-50-P