ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS 69390 F 15 PPM DISPOSITION 69390 F 15 PPM SPECIAL 08 31 01 06 27 01 07 11 01 07 25 01 08 15 01 08 22 01 08 31 01 08 08 01 08 15 01 08 30 01 06 13 01 07 11 01 07 18 01 07 25 01 07 11 01 07 25 01 08 22 01 06 06 01 06 13 01 06 20 01 06 27 01 07 04 01 07 11 01 07 18 01 08 01 01 08 22 01 08 30 01 06 06 01 06 13 01 7~ 46 P 6: 36 P 6: 37 P 7: 09 P 7: 34 P 6: 37 P 7: lO P 6: 33 P 7: 34 P 7: 58 P 7: lO P 6: 38 P 7: 38 P 7: 09 P 6: 38 P 7: 09 P 6: 37 P 7~ 46 P 7: 09 P 6: 53 P 6~ 37 P 6: 15 P 6: 38 P 7: 38 P 7: 03 P 6: 37 P 7: 39 P 7~ 46 P 7: lO P   _ _ _ _ .__ PRIMARY NECROPSY (WEEK 13) DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS PRIMARY NECROPSY (WEEK 13) SCABBING END OF TAIL SCABBING END OF TAIL SCABBING END OF TAIL SCABBING END OF TAIL WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA END OF TAIL MISSING END OF TAIL MISSING END OF TAIL MISSING END OF TAIL MISSING END OF TAIL MISSING END OF TAIL MISSING END OF TAIL MISSING END OF TAIL MISSING END OF TAIL MISSING END OF TAIL MISSING NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS 69393 F 15 PPM NORMAL 69393 F 15 PPM DISPOSITION 69393 F 15 PPM BODY/ INTEG II 69393 F 15 PPM SPECIAL 69393 F 15 PPM SPECIAL II % o\

G 69396 F 15 PPM NORMAL __________________________________, __ ._________________________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE DETAILED PHYSICAL EXAMINATIONS/ DISPOSITIONS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 29 TABLE RANGE: 05 31 01 TO 08 31 01 ________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS __________________________________

69396 F 15 PPM NORMAL 06 20 01 6: 54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 27 01 6: 37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 11 01 6: 38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 18 01 7: 38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 25 01 7: lO P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 01 01 7: 04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7: 34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 30 01 7: 36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 69396 F 15 PPM DISPOSITION 08 30 01 7~ 57 P PRIMARY NECROPSY (WEEK 13) 69396 F 15 PPM SPECIAL 08 22 01 6: 38 P WET YELLOW MATERIAL UROGENITAL AREA 69409 F 15 PPM NORMAL 06 06 01 7: 47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: lO P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 20 01 6: 54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 27 01 6: 37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 11 01 6: 39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 18 01 7: 38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 25 01 7: lO P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 01 01 7: 04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7: 35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 30 01 7: 34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 69409 F 15 PPM DISPOSITION 08 30 01 7: 56 P PRIMARY NECROPSY (WEEK 13) 69409 F 15 PPM SPECIAL II 08 22 01 6: 38 P TAIL BROKEN 69413 F 15 PPM NORMAL 06 06 01 7: 47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: lO P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 20 01 6: 54 P NO SIGNIFICANT CLINICAL OBSERVATIONS GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE DETAILED PHYSICAL EXAMINATIONS/ DISPOSITIONS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 30 TABLE RANGE: 05 31 01 TO 08 31 01 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS 69413 F 15 PPM NORMAL 06 27 01 6: 37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 11 01 6: 39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 18 01 7: 38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 25 01 7: lO P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 01 01 7: 04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7~ 35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 22 01 6: 38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 31 01 7: lO P NO SIGNIFICANT CLINICAL OBSERVATIONS 69413 F 15 PPM DISPOSITION 08 31 01 7: 46 P PRIMARY NECROPSY (WEEK 13) 69435 F 15 PPM NORMAL 06 06 01 7: 47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: ll P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 20 01 6: 55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 27 01 6: 37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 18 01 7: 38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 01 01 7: 04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7: 35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 22 01 6: 38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 30 01 7: 38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 69435 F 15 PPM DISPOSITION 08 30 01 7: 58 P PRIMARY NECROPSY (WEEK 1.3) 69435 F 15 PPM SPECIAL 07 11 01 6: 40 P WET YELLOW MATERIAL UROGENITAL AREA 07 25 01 7: lO P WET YELLOW MATERIAL UROGENITAL AREA 69359 F 40 PPM NORMAL 06 06 01 7~ 52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: 14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 20 01 7: 00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 27 01 6: 39 P NO SIGNIFICANT CLINICAL OBSERVATIONS ___________________________________

GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE DETAILED PHYSICAL EXAMINATIONS/ DISPOSITIONS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 31 TABLE RANGE: 05 31 01 TO 08 31 01 ____________________________________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ______________________________________

69359 F 40 PPM NORMAL 07 04 01 6: 18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 11 01 6: 46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 18 01 7: 41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 25 01 7: 15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 01 01 7: ll P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7: 38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 30 01 7: 33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 69359 F 40 PPM DISPOSITION 08 30 01 7~ 55 P PRIMARY NECROPSY (WEEK 13) 69359 F 40 PPM SPECIAL 08 22 01 6: 41 P DRIED YELLOW MATERIAL UROGENITAL AREA 69369 F 40 PPM NORMAL 06 06 01 7: 52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: 14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 20 01 7: 00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: l. E P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 11 01 6: 46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 18 01 7: 42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 25 01 7: l. 5 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 01 01 7: L2 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7: 39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 22 01 6: 41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 31 01 7: lO P NO SIGNIFICANT CLINICAL OBSERVATIONS 69369 F 40 PPM DISPOSITION 08 31 01 7: 46 P PRIMARY NECROPSY (WEEK 13) 69369 F 40 PPM CARDIO PULMONARY 06 27 01 6: 39 P RALES 69370 F 40 PPM NORMAL 06 06 01 7: 52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: lS P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 20 01 7: Ol P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 27 01 6: 40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 19 P NO SIGNIFICANT CLINICAL OBSERVATIONS _______________________________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE DETAILED PHYSICAL EXAMINATIONS/ DISPOSITIONS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 32 TABLE RANGE: 05 31 01 TO 08 31 01 ___________________________________

ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS 69370 F 40 PPM NORMAL 07 18 01 7: 43 P 08 08 01 6: 38 P 08 15 01 7: 40 P 08 22 01 6: 41 P 08 30 01 7~ 32 P DISPOSITION 08 30 01 7: 55 P CARDIO PULMONARY 07 11 01 6: 47 P BODY/ INTEG II 07 25 01 7: 15 P 08 01 01 7~ 12 P NORMAL 06 06 01 7: 53 P 06 13 01 7: 15 P 06 27 01 6: 40 P 07 04 01 6: 19 P 07 18 01 7: 43 P 07 25 01 7: 16 P 08 01 01 7: 13 P 08 08 01 6: 38 P 08 22 01 6: 41 P DISPOSITION 08 31 01 7: 47 P SPECIAL 06 20 01 7: Ol P 07 11 01 6: 47 P 08 15 01 7: 40 P 08 31 01 7: lO P NORMAL 06 06 01 7: 53 P 06 13 01 7: 15 P 06 27 01 6: 40 P 07 04 01 6: 19 P 07 11 01 6: 48 P 07 18 01 7: 43 P ___________________________________ NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS PRIMARY NECROPSY (WEEK 13) RALES SCABBING END OF TAIL SCABBING END OF TAIL NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS PRIMARY NECROPSY (WEEK 13') WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS 69370 F 40 PPM 69370 F 40 PPM 69370 F 40 PPM 69380 F % 69380 F 69380 F cl l 6 69388 F _________ GRADE CODE: 1 40 PPM 40 PPM 40 PPM 40 PPM SLIGHT 2  MODERATE 3  SEVERE P PRESENT  DETAILED PHYSICAL EXAMINATIONS/ DISPOSITIONS PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE PAGE 33 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 05 31 01 TO 08 31 01 ____________________________________~ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS _______________________________________ 69388 F 40 PPM NORMAL 07 25 01 7: 16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 01 01 7: 13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7: 40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 30 01 7: 35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 69388 F 40 PPM DISPOSITION 08 30 01 7: 56 P PRIMARY NECROPSY (WEEK 13) 69388 F 40 PPM SPECIAL 06 20 01 7: 02 P DRIED YELLOW MATERIAL VENTRAL TRUNK 08 22 01 6: 42 P DRIED YELLOW MATERIAL UROGENITAL AREA 69394 F 40 PPM NORMAL 06 06 01 7: 53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: 15 P NO SIGNLFICANT CLINICAL OBSERVATIONS 06 20 01 7: 02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 27 01 6: 40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 11 01 6: 48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 18 01 7: 43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 25 01 7: 16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 01 01 7: 13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7: 41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 22 01 6: 42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 31 01 7: ll P NO SIGNIFICANT CLINICAL OBSERVATIONS 69394 F 40 PPM DISPOSITION 08 31 01 7~ 47 P PRIMARY NECROPSY (WEEK 13) 69426 F 40 PPM NORMAL 06 06 01 7: 54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: 16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 20 01 7: 03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 27 01 6: 40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 11 01 6: 49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 18 01 7: 44 P NO SIGNIFICANT CLINICAL OBSERVATIONS __________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT DETAILED PHYSICAL EXAMINATIONS/ DISPOSITIONS PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE PAGE 34 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 05 31 01 TO 08 31 01 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS _____________________________________~~ 69426 F 40 PPM NORMAL 07 25 01 7: 17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 01 01 7: 13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7: 41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 31 01 7: ll P NO SIGNIFICANT CLINICAL OBSERVATIONS 69426 F 40 PPM DISPOSITION 08 31 01 7: 47 P PRIMARY NECROPSY (WEEK 13) 69426 F 40 PPM SPECIAL 08 22 01 6: 42 P DRIED YELLOW MATERIAL UROGENITAL AREA 69428 F 40 PPM NORMAL 06 06 01 7: 54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: 16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 20 01 7: 03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 27 01 6: 40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 11 01 6: 50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 18 01 7: 44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 25 01 7: 17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 01 01 7: 14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7: 42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 69428 F 40 PPM DISPOSITION 08 31 01 7: 47 P PRIMARY NECROPSY (WEEK 13) 69428 F 40 PPM EYES/ EARS/ NOSE 08 22 01 6: 42 P DRIED RED MATERIAL AROUND LEFT EYE 08 31 01 7: 12 P DRIED RED MATERIAL AROUND LEFT EYE 69428 F 40 PPM SPECIAL 08 22 01 6: 43 P WET YELLOW MATERIAL UROGENITAL AREA 69433 F 40 PPM NORMAL 06 06 01 7: 55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: 16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 20 01 7: 03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 27 01 6: 41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 11 01 6: 50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 25 01 7: 17 P NO SIGNIFICANT CLINICAL OBSERVATIONS _____________________________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE DETAILED PHYSICAL EXAMINATIONS/ DISPOSITIONS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 35 TABLE RANGE: 05 31 01 TO 08 31 01 ANIMAL SEX ___________ 69433 F 69433 F 69433 F 69436 F 69436 F 40 PPM DISPOSITION 69436 F 40 PPM SPECIAL % m 6 69375 F 100 PPM NORMAL __________ GRADE CODE: 1 _ GROUP CATEGORY ___________________ 40 PPM NORMAL 40 PPM DISPOSITION 40 PPM SPECIAL 40 PPM NORMAL __________________ SLIGHT 2  MODERATE 3  DATE TIME GRADE OBSERVATIONS 08 08 01 6: 40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 30 01 7: 33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 30 01 7: 56 P PRIMARY NECROPSY (WEEK 13) 07 18 01 7: 45 p DRIED YELLOW MATERIAL UROGENITAL AREA 08 01 01 7: 14 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 15 01 7: 42 P WET YELLOW MATERIAL UROGENITAL AREA 08 22 01 6: 43 P WET YELLOW MATERIAL UROGENITAL AREA 06 06 01 7~ 55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: 16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 22 01 6: 43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 30 01 7: 54 P PRIMARY NECROPSY (WEEK 13) 06 20 01 7: 04 P WET YELLOW MATERIAL UROGENITAL AREA 06 27 01 6: 41 P DRIED YELLOW MATERIAL UROGENITAL AREA 07 11 01 6: 51 P DRIED YELLOW MATERIAL UROGENITAL AREA 07 18 01 7: 45 P WET YELLOW MATERIAL UROGENITAL AREA 07 25 01 7: 18 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 01 01 7: 15 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 15 01 7~ 42 P WET YELLOW MATERIAL UROGENITAL AREA 08 30 01 7: 31 P DRIED YELLOW MATERIAL UROGENITAL AREA 06 06 01 8: 00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: 20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 20 01 7: 09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 27 01 6: 43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 11 01 6: 57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 18 01 7: 49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 25 01 7: 22 P NO SIGNIFICANT CLINICAL OBSERVATIONS ______________________________________~~~~~ SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE DETAILED PHYSICAL EXAMINATIONS/ DISPOSITIONS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 36 TABLE RANGE: 05 31 01 TO 08 31 01 _______________________________________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS __________________ 69375 F 100 PPM NORMAL 08 01 01 7: 20 08 08 01 6: 43 08 15 01 7: 46 08 30 01 7~ 32 08 30 01 7: 55 08 22 01 6: 46 06 06 01 8: 00 06 13 01 7: 20 06 20 01 7: 09 06 27 01 6: 43 07 04 01 6: 24 07 11 01 6: 57 07 18 01 7: 49 08 01 01 7: 20 08 08 01 6: 43 08 15 01 7: 46 08 22 01 6: 46 08 30 01 7: 37 08 30 01 7: 57 07 25 01 7~ 22 P P P P P P P P P P P P P P P P P P P P P P P P P P P P NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS PRIMARY NECROPSY (WEEK 13) DRIED YELLOW MATERIAL UROGENITAL AREA NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS PRIMARY NECROPSY (WEEK 13) SOFT FECES NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS 69375 F 100 PPM DISPOSITION 69375 F 100 PPM SPECIAL 69379 F 100 PPM NORMAL % 69379 F 69379 F m G 69383 F 100 PPM NORMAL GRADE CODE: 1 100 PPM DISPOSITION 100 PPM EXCRETA _____ ____________ SLIGHT 2  MODERATE 3  06 06 01 8: 00 06 13 01 7: 20 06 20 01 7: 09 06 27 01 6: 44 07 04 01 6: 25 07 11 01 6: 57 07 18 01 7: 49 07 25 01 7~ 22 __________ C____. SEVERE ??  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE ____________________ ANIMAL SEX GROUP _____________________ 69383 F 100 PPM 69383 F 100 PPM 69385 F 100 PPM 69385 F 100 PPM 69385 F 100 PPM 69392 F 100 PPM ___ DETAILED PHYSICAL EXAMINATIONS/ DISPOSITIONS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 37 TABLE RANGE: 05 31 01 TO 08 31 01 _______________________________ CATEGORY DATE TIME GRADE OBSERVATIONS _______________________________~~~~~ NORMAL 08 01 01 7: 20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7: 46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 22 01 6: 46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 31 01 7: 12 P NO SIGNIFICANT CLINICAL OBSERVATIONS DISPOSITION 08 31 01 7: 47 P PRIMARY NECROPSY (WEEK 13) NORMAL 06 06 01 8: Ol P NO SIGNIFICANT CLINICAL 06 13 01 7: 21 P NO SIGNIFICANT CLINICAL 06 20 01 7: lO P NC) SIGNIFICANT CLINICAL 07 04 01 6: 25 p NO SIGNIFICANT CLINICAL 07 11 01 6: 58 p NO SIGNIFICANT CLINICAL 07 18 01 7: 50 P NO SIGNIFICANT CLINICAL 07 25 01 7: 23 P NO SIGNIFICANT CLINICAL 08 01 01 7: 20 P NO SIGNIFICANT CLINICAL 08 08 01 6: 44 P NO SIGNIFICANT CLINICAL 08 15 01 7: 46 P NO SIGNIFICANT CLINICAL 08 22 01 6: 46 P NO SIGNIFICANT CLINICAL 08 31 01 DISPOSITION 08 31 01 CARDIO PULMONARY 06 27 01 NORMAL 06 06 01 06 13 01 06 20 01 06 27 01 07 04 01 07 11 01 07 18 01 07 25 01 08 01 01 7: 12 7: 47 6: 44 8: Ol 7: 21 7: lO 6: 44 6: 25 6: 58 7: 50 7~ 23 7: 21 P P P P P P P P P P P P OBSERVATIONS OBSERVATIONS OBSERVATIONS OBSERVATIONS OBSERVATIONS OBSERVATIONS OBSERVATIONS OBSERVATIONS OBSERVATIONS OBSERVATIONS OBSERVATIONS OBSERVATIONS NO SIGNIFICANT CLINICAL PRIMARY NECROPSY (WEEK 13) FALES NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS NO SIGNIFICANT CLINICAL OBSERVATIONS _______________~~~ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT DETAILED PHYSICAL EXAMINATIONS/ DISPOSITIONS PROJECT NO.: WIL 417002 BO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 38 SPONSOR: HAP TASK FORCE INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 05 31 01 TO 08 31 01 _______________________________________

ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS 69392 F 69392 F 69402 F 69402 F % 69402 F 69408 F a 5;

69408 F _. 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM _____________. NORMAL DISPOSITION NORMAL DISPOSITION SPECIAL NORMAL DISPOSITION 08 08 01 08 15 01 08 22 01 08 31 01 08 31 01 06 06 01 06 13 01 06 20 01 06 27 01 07 04 01 07 18 01 07 25 01 08 01 01 08 08 01 08 15 01 08 22 01 08 31 01 08 31 01 07 11 01 06 06 01 06 13 01 06 27 01 07 04 01 07 18 01 07 25 01 08 01 01 08 08 01 08 15 01 08 31 01 ._______ __ 6~ 44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7: 4 l P NO SIGNIFICANT CLINICAL OBSERVATIONS 6: 46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7~ 12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7: 47 P PRIMARY NECROPSY (WEEK 13) 8: Ol P NO SIGNIFICANT CLINICAL OBSERVATIONS 7: 21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7: lO P NO SIGNIFICANT CLINICAL OBSERVATIONS 6: 44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 6: 25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7: 50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7~ 23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7: 21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 6: 44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7: 47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 6~ 47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7~ 12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7: 47 P PRIMARY NECROPSY (WEEK 13) 6: 59 P WET YELLOW MATERIAL UROGENITAL AREA 8: 02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7: 22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 6: 45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 6: 26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7: 51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7~ 24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7~ 23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 6~ 45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 7: 47 P NO SIGNIFICANT CLINICAL OBSERVATIONS I: 47 P PRIMARY NECROPSY (WEEK 1.3)

GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE DETAILED PHYSICAL EXAMINATIONS/ DISPOSITIONS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 39 TABLE RANGE: 05 31 01 TO 08 31 01 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS 69408 F 100 PPM SPECIAL 06 20 01 7: ll P WET YELLOW MATERIAL UROGENITAL AREA 07 11 01 7: 00 P WET YELLOW MATERIAL UROGENITAL AREA 08 22 01 6: 47 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 31 01 7~ 12 P DRIED YELLOW MATERIAL UROGENITAL AREA 69415 F 100 PPM NORMAL 06 06 01 8: 02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: 22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 27 01 6: 45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 25 01 7: 24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 45 P NO SIGNIFICANT CLINICAL. OBSERVATIONS 69415 F 100 PPM DISPOSITION 08 30 01 7: 58 P PRIMARY NECROPSY (WEEK 13) 69415 F 100 PPM SPECIAL 06 20 01 7: ll P DRIED YELLOW MATERIAL UROGENITAL AREA 07 11 01 7: 00 P WET YELLOW MATERIAL UROGENITAL AREA 07 18 01 7: 51 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 01 01 7~ 24 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 15 01 7: 48 P WET YELLOW MATERIAL UROGENITAL AREA 08 22 01 6~ 47 P WET YELLOW MATERIAL UROGENITAL AREA 08 30 01 7~ 37 P DRIED YELLOW MATERIAL UROGENITAL AREA 69427 F 100 PPM 06 06 01 8: 03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 13 01 7: 22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 20 01 7: ll P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 27 01 6: 45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 11 01 7: Ol P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 18 01 7: 52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 25 01 7~ 24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 01 01 7: 24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7: 48 P NO SIGNIFICANT CLINICAL OBSERVATIONS __________________~ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 DETAILED PHYSICAL EXAMINATIONS/ DISPOSITIONS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 40 TABLE RANGE: 05 31 01 TO 08 31 01 ______________________________________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS 69427 F 100 PPM DISPOSITION 08 30 01 7: 55 P PRIMARY NECROPSY (WEEK 13) 69427 F 100 PPM SPECIAL 08 22 01 6: 47 P WET YELLOW MATERIAL UROGENITAL AREA 08 30 01 7: 33 P DRIED YELLOW MATERIAL UROGENITAL AREA 69431 F 100 PPM NORMAL 06 06 01 8: 03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 06 20 01 7: 12 P NO SIGNlFICANT CLINICAL OBSERVATIONS 06 27 01 6~ 45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 04 01 6: 26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 07 11 01 7: Ol P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 01 01 7: 24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 08 01 6: 45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 15 01 7: 48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 08 30 01 7: 31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 69431 F 100 PPM DISPOSITION 08 30 01 7: 55 P PRIMARY NECROPSY (WEEK 13) 69431 F 100 PPM SPECIAL 06 13 01 7: 23 P WET YELLOW MATERIAL UROGENITAL AREA 07 18 01 7~ 52 P WET YELLOW MATERIAL UROGENITAL AREA 07 25 01 7~ 25 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 22 01 6: 48 P WET YELLOW MATERIAL UROGENITAL AREA _______________________________________~

GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PCRDv4.04 11/ 28/ 2001 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE PRIOR TO EXPOSURE YO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 1 TABLE RANGE: 05 31 01 TO 08 30 01 ______________________________________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS 69306 M 0 PPM EYES/ EARS/ NOSE 69314 M 0 PPM EYES/ EARS/ NOSE 69314 M 69317 M 69343 M 69343 M 69335 M 69335 M 69335 M 69338 M % o\

s 69338 M 69324 M 40 PPM EYES/ EARS/ NOSE 0 PPM 0 PPM 0 PPM 0 PPM 15 PPM 15 PPM 15 PPM 15 PPM 15 PPM 07 12 01 08 06 01 08 30 01 08 29 01 06 20 01 69304 M 100 PPM SPECIAL 69307 M 100 PPM EXCRETA 7 38 P 55 P 56 P 21 P 35 P DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE DRIED YELLOW MATERIAL UROGENITAL AREA SOFT FECES WET BROWN MATERIAL ANOGENITAL AREA 69318 M 100 PPM SPECIAL 07 19 01 7 29 P _____________________________________ GRADE CODE: 1  SLIGHT 2  MODEFATE 3  SEVERE P  PRESENT EXCRETA EYES/ EARS/ NOSE EYES/ EARS/ NOSE SPECIAL EYES/ EARS/ NOSE EXCRETA SPECIAL EYES/ EARS/ NOSE EXCRETA 07 31 01 07 31 01 07 09 01 07 31 01 07 31 01 07 31 01 o 7 09 01 06 21 01 08 17 01 OS 17 Ol. 08 13 01 08 17 01 06 14 01 06 15 01 06 15 01 06 15 01 07 24 01 07 31 01 08 03 01 08 24 01 07 09 01 6 6 7 6 7 6 7 6 12 P 13 P 33 P 14 P 14 P 14 P 33 P 40 P 42 P 42 P 10 P 42 P 38 P 51 P 52 P 52 P 23 P 22 P 45 P 25 P 43 P DRIED RED MATERIAL AROUND RIGHT EYE RED DISCHARGE RIGHT EYE DRIED RED MATERIAL AROUND LEFT EYE RED DISCHARGE LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND RIGHT EYE SOFT FECES DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND RIGHT EYE WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED RED MATERIAL AROUND NOSE DRIED RED MATERIAL AROUND NOSE DECREASED DEFECATION DRIED YELLOW MATERIAL UROGENITAL AREA DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE SOFT FECES PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE PRIOR TO EXPOSURE 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 2 TABLE RANGE: 05 31 01 TO 08 30 01 _______~________________________~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ____________________________________ 69318 M 69319 M 100 PPM 100 PPM SPECIAL SPECIAL 69329 M 69329 M 69346 M 100 PPM EYES/ EARS/ NOSE 100 PPM SPECIAL 100 PPM EXCRETA 0 PPM SPECIAL 0 PPM EYES/ EARS/ NOSE 0 PPM SPECIAL 0 PPM SPECIAL 0 PPM SPECIAL 0 PPM SPECIAL 0 PPM SPECIAL 08 29 01 08 02 01 08 30 01 07 19 01 08 29 01 08 29 01 08 29 01 7: 21 P 6: 23 P 7: 03 P 7: 30 P 7: 22 P 7: 22 P 7: 24 P DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND RIGHT EYE WET YELLOW MATERIAL UROGENITAL AREA SOFT FECES 69366 F 69367 F 69367 F 69378 F 69398 F 69404 F 69416 F cn G 69419 F 69419 F 69432 F 69432 F 0 PPM 0 PPM EYES/ EARS/ NOSE SPECIAL 0 PPM 0 PPM BODY/ INTEGUMENT EYES/ EARS/ NOSE 07 31 01 6~ 15 P 08 03 01 6: 34 P 07 31 01 6: 16 P 07 31 01 6: 16 P 07 31 01 6: 17 P 07 31 01 6~ 17 P 07 26 01 7~ 24 P 07 31 01 6: 18 P 07 31 01 6: 18 P 08 03 01 6: 39 P 08 07 01 7: 19 P 08 17 01 6~ 44 P 08 28 01 I: 33 P 07 26 01 7: 2s P 07 09 01 7: 37 P 07 31 01 6: 19 P 08 20 01 7: 18 P 08 29 01 7~ 27 P 08 16 01 7: Ol P 08 16 01 7: 05 P 08 16 01 7: 05 P DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED RED MATERIAL AROUND RIGHT EYE DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED RED MATERIAL AROUND LEFT EYE WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DERMAL ATONIA DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND LEFT EYE _____________________________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PRIOR TO EXPOSURE PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 3 SPONSOR: HAP TASK FORCE INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 05 31 01 TO 08 30 01 ____________________________________~~~ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ___________________________________ 69432 F 0 PPM EYES/ EARS/ NOSE 08 17 01 08 17 01 69432 F 0 PPM EXCRETA 08 16 01 69432 F 0 PPM SPECIAL 08 14 01 08 16 01 08 16 01 08 16 01 08 17 01 08 17 01 08 20 01 69362 F 15 PPM SPECIAL 08 03 01 69376 F 15 PPM EYES/ EARS/ NOSE 08 03 01 69376 F 15 PPM SPECIAL ;D 69382 F 15 PPM SPECIAL 69390 F 15 PPM SPECIAL ________________ _______ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT 08 29 01 08 29 01 06 21 01 07 09 01 07 24 01 08 03 01 08 09 01 08 13 01 08 17 01 08 29 01 08 10 01 07 02 01 07 17 01 07 31 01 08 14 01 08 21 01 08 29 01 6 6 7 6 45 P 45 P 07 P 22 P 06 P 06 P 06 P 45 P 45 P 18 P 46 P 47 P 32 P 32 P 46 P 45 P 24 P 47 P 24 P 11 P 50 P 32 P 16 P 45 P 45 P 24 P 26 P 04 P 33 P DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND LEFT EYE DECREASED DEFECATION DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL HINDLIMB WET YELLOW ANOGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW ANOGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRI. ED YELLOW MATERIAL UROGENITAL AREA DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND LEFT EYE DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE ANIMAL SEX ___________ 69393 F 69409 F GROUP ._ _____ 15 PPM 15 PPM 69359 F 69380 F 2 69426 F cn 69428 F 0 69436 F rh cn z 69375 F 69392 F 69408 F CATEGORY __________ SPECIAL TABLE RANGE: 05 31 01 TO 08 30 01 _____________________________________~~~

DATE TIME GRADE OBSERVATIONS __ ___________________________

SPECIAL 40 PPM 40 PPM SPECIAL SPECIAL 40 PPM SPECIAL 40 PPM EYES/ EARS/ NOSE 40 PPM SPECIAL 100 PPM 100 PPM 100 PPM SPECIAL SPECIAL SPECIAL PRIOR TO EXPOSURE 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 4 07 31 01 08 09 01 08 14 01 07 09 01 07 09 01 07 09 01 07 17 01 08 03 01 08 21 01 08 29 01 06 20 01 06 22 01 07 31 01 08 14 01 08 20 01 08 21 01 08 30 01 08 30 01 06 15 01 06 22 01 07 17 01 08 29 01 08 29 01 08 20 01 08 23 01 08 23 01 08 20 01 08 30 01 07 10 01 6: 25 6: 25 I: 21 7: 47 7: 47 7: 47 6: 44 6: 49 6: 52 7: 33 7: 42 8: 03 6: 22 7~ 27 7: 02 6: 52 6: 58 6: 59 8: 08 8: 03 6: 35 7: 36 7: 36 7: 08 7: 32 7~ 32 7: lO 7: 06 7: 40 P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL VENTRAL TRUNK P DRIED YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P DRIED RED MATERIAL AROUND LEFT EYE P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE PRIOR TO EXPOSURE 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 5 TABLE RANGE: 05 31 01 TO 08 30 01 ________________________________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ____________________________________~~~~~~~~~~~~ 69408 F 100 PPM SPECIAL 07 24 01 6: 37 P 08 09 01 6: 31 P 08 09 01 6: 31 P 08 09 01 6: 32 P 08 23 01 7: 34 P 69415 F 100 PPM SPECIAL 07 24 01 6: 38 P 08 02 01 6~ 27 P 08 07 01 7: 29 P 08 17 01 6~ 44 P 08 21 01 7: oo P 08 23 01 7: 34 P 69427 F 100 PPM SPECIAL 07 24 01 6: 38 P 08 02 01 6: 28 P 08 02 01 6: 28 P 08 07 01 7: 29 P 08 21 01 7: Ol P 08 23 01 7: 35 P 08 29 01 7~ 27 P 69431 F 100 PPM SPECIAL 07 24 01 6: 38 P 07 31 01 6: 28 P 08 02 01 6: 28 P 08 23 01 7: 35 P 08 29 01 7: 27 P WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED BROWN MATERIAL ANOGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA _____________________________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PCRDv4.04 11/ 28/ 2001 FOLLOWING EXPOSURE PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 1 TABLE RANGE: 05 31 01 TO 08 30 01 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS _______________________________________ 69306 69308 69314 69317 69317 69331 69343 69343 69320 69335 69335 % 69338 0, 69303 ch 69313 s 69324 69348 69348 69304 69307 69318 M 0 PPM 0 PPM 0 PPM 0 PPM 0 PPM 0 PPM 0 PPM 0 PPM 15 PPM 15 PPM 15 PPM 15 PPM 40 PPM 40 PPM 40 PPM 40 PPM 40 PPM 100 PPM 100 PPM 100 PPM EYES/ EARS/ NOSE SPECIAL EYES/ EARS/ NOSE EXCRETA SPECIAL SPECIAL EYES/ EARS/ NOSE SPECIAL SPECIAL EYES/ EARS/ NOSE SPECIAL EYES/ EARS/ NOSE EXCRETA SPECIAL EYES/ EARS/ NOSE EXCRETA SPECIAL SPECIAL EYES/ EARS/ NOSE SPECIAL 07 28 01 7: 35 P 07 29 01 7: 29 P 07 21 01 8: 08 P 07 08 01 6: 45 P 07 29 01 7: 29 P 08 11 01 7: 51 P 08 11 01 7: 51 P 08 11 01 7: 52 P 08 12 01 13: 13 P 08 12 01 13: 13 P 08 11 01 7: 56 P 06 16 01 7: 03 P 06 17 01 6: 54 P 06 16 01 7: 03 P 07 21 01 8: 13 P 07 28 01 7: 39 P 08 25 01 7: 44 P 08 12 01 13: 16 P 08 05 01 7: 45 P 07 29 01 7: 33 P 08 12 01 13: 16 P DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE WET BROWN MATERIAL ANOGENITAL AREA DRIED RED MATERIAL AROUND LEFT EYE RED DISCHARGE LEFT EYE SOFT FECES WET BROWN MATERIAL ANOGENITAL AREA DRIED BROWN MATERIAL ANOGENITAL AREA DRIED RED MATERIAL AROUND LEFT EYE WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED RED MATERIAL AROUND NOSE DRIED RED MATERIAL AROUND NOSE DRIED YELLOW MATERIAL UROGENITAL AREA DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE SOFT FECES DRIED BROWN MATERIAL ANOGENITAL AREA DRIED RED MATERIAL AROUND LEFT EYE SOFT FECES 07 21 01 a: 18 P WET BROWN MATERIAL ANOGENITAL AREA 08 12 01 13: 16 P WET BROWN MATERIAL ANOGENITAL AREA 08 25 01 7: 47 P WET YELLOW MATERIAL UROGENITAL AREA 08 26 01 7: 32 P DRIED RED MATERIAL AROUND RIGHT EYE 08 25 01 7: 48 P WET YELLOW MATERIAL UROGENITAL AREA ______________________________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT FOLLOWING EXPOSURE PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 2 SPONSOR: HAP TASK FORCE INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 05 31 01 TO 08 30 01 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ______________________________________ 69318 M 69329 M 69366 F 69367 F 69367 F 69384 F 69384 F 69398 F % 69404 F ch ;;

69416 F ___. GRADE CODE: 1 100 PPM 100 PPM 0 PPM 0 PPM 0 PPM SPECIAL EYES/ EARS/ NOSE SPECIAL EYES/ EARS/ NOSE SPECIAL 0 PPM 0 PPM 0 PPM EXCRETA SPECIAL SPECIAL 0 PPM SPECIAL 0 PPM SPECIAL 08 26 01 7: 32 P 07 21 01 8: 21 P 08 11 01 7: 53 P 07 28 01 7: 36 P 07 29 01 7: 30 P 07 01 01 6: 49 P 07 28 01 7: 36 P 07 29 01 7: 30 P 08 04 01 6: 32 P 08 26 01 7: 27 P 07 29 01 7: 30 P DRIED YELLOW MATERIAL UROGENITAL AREA DRIED RED MATERIAL AROUND RIGHT EYE DRIED YELLOW MATERIAL UROGENITAL AREA RED DISCHARGE RIGHT EYE DRIED RED MATERIAL AROUND RIGHT EYE DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA SOFT FECES 07 28 01 7: 37 P WET YELLOW MATERIAL UROGENITAL AREA 08 04 01 6: 31 P DRIED YELLOW MATERIAL UROGENITAL AREA 06 17 01 6: 55 P DRIED YELLOW MATERIAL UROGENITAL AREA 06 23 01 8: Ol P WET YELLOW MATERIAL UROGENITAL AREA 07 01 01 6: 49 P DRIED YELLOW MATERIAL UROGENITAL AREA 07 28 01 7: 37 P WET YELLOW MATERIAL UROGENITAL AREA 08 11 01 7: 53 P DRIED YELLOW MATERIAL UROGENITAL AREA 07 21 01 8: lO P WET YELLOW MATERIAL UROGENITAL AREA 07 29 01 7: 31 P WET YELLOW MATERIAL UROGENITAL AREA 08 11 01 7: 53 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 25 01 7~ 42 P WET YELLOW MATERIAL UROGENITAL AREA 07 28 01 7~ 37 P WET YELLOW MATERIAL UROGENITAL AREA 08 04 01 6: 32 P WET YELLOW MATERIAL UROGENITAL AREA 08 05 01 7: 42 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 11 01 7: 54 P DRIED YELLOW MATERIAL ANOGENITAL AREA 08 12 01 13: 13 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 25 01 7: 43 P DRIED YELLOW MATERIAL UROGENITAL AREA ________________________________~~~~~~~~~ SLIGHT 2  MODERATE 3  SEVERE P  PRESENT FOLLOWING EXPOSURE PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 3 SPONSOR: HAP TASK FORCE INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 05 31 01 TO 08 30 01 ____________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS _____________________________________ 69416 F 69419 F 69419 F 0 PPM 0 PPM 0 PPM WET YELLOW MATERIAL UROGENITAL AREA RALES 69419 F 0 PPM 69432 F 0 PPM 69376 F 15 PPM 69377 F 69377 F 69382 F __________ 15 PPM 15 PPM 15 PPM SPECIAL 08 26 01 7: 28 CARDIO PULMONARY 07 22 01 7: 08 EYES/ EARS/ NOSE 07 21 01 8: ll 07 22 01 7: oe 07 22 01 7: 08 SPECIAL 07 28 01 7: 38 07 29 01 7: 31 08 04 01 6: 31 08 05 01 7: 41 08 25 01 7: 43 SPECIAL 08 04 01 6: 31 08 11 01 7: 55 08 11 01 7: 55 08 12 01 13: 14 08 12 01 13: 14 SPECIAL 06 10 01 6: 54 06 17 01 6: 52 06 23 01 7: 59 06 30 01 7: 11 07 01 01 6: 49 07 29 01 7: 33 08 04 01 6: 30 08 11 01 7: 56 08 12 01 13: 15 EYES/ EARS/ NOSE 06 30 01 7: 16 06 30 01 7: 16 SPECIAL 06 30 01 7: ll 06 30 01 7: ll SPECIAL 08 11 01 7: 57 P P P P P P P P P P P P P P P P P P P P P P P P P P P P P DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE RED DISCHARGE LEFT EYE WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL HINDLIMB WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND LEFT EYE DRIED YELLOW MATERIAL VENTRAL TRUNK DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT FOLLOWING EXPOSURE PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 4 SPONSOR: HAP TASK FORCE INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 05 31 01 TO 08 30 01 ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ______________________^_______________~~~~~~ 69390 F 15 PPM SPECIAL 69409 F 15 PPM SPECIAL 69380 F 40 PPM SPECIAL 69388 F 40 PPM SPECIAL 69426 F 40 PPM SPECIAL 69433 F 40 PPM SPECIAL 69436 F 40 PPM SPECIAL 69375 69385 69408 69415 F 100 PPM SPECIAL F 100 PPM F 100 PPM F 100 PPM SPECIAL SPECIAL SPECIAL 07 01 01 07 01 01 07 21 01 07 28 01 08 25 01 08 26 01 07 28 01 06 23 01 08 25 01 08 26 01 07 21 01 07 28 01 06 16 01 06 16 01 06 17 01 06 30 01 07 01 01 08 05 01 08 25 01 08 26 01 07 29 01 08 11 01 07 29 01 07 21 01 08 05 01 08 11 01 08 25 01 06 17 01 06 23 01 6: 49 6: 49 8: 16 7: 39 7: 45 7: 29 7: 41 8: 00 7: 46 7: 31 8: lY 7: 42 7: 04 7: 04 6: 51 7: 12 6: 51 7~ 46 7: 47 7: 31 7: 35 7: 59 7136 8: 25 7~ 48 7: 59 7: 48 6: 50 7: 58 P DRIED YELLOW MATERIAL VENTRAL TRUNK P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P WET YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA P DRIED YELLOW MATERIAL UROGENITAL AREA GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT FOLLOWING EXPOSURE PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE PAGE 5 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 05 31 01 TO 08 30 01 ___________________________^_________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS _______________________________________ 69415 F 100 PPM SPECIAL 06 24 01 6: 51 P WET YELLOW MATERIAL UROGENITAL AREA 07 21 01 8: 24 P WET YELLOW MATERIAL UROGENITAL AREA 07 28 01 7: 43 P WET YELLOW MATERIAL UROGENITAL AREA 07 29 01 7: 36 P WET YELLOW MATERIAL UROGENITAL AREA 08 05 01 7141 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 11 01 8: 00 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 11 01 8: 00 P DRIED YELLOW MATERIAL ANOGENITAL AREA 08 12 01 13: 18 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 25 01 7: 49 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 26 01 69427 F 7: 33 P DRIED YELLOW MATERIAL UROGENITAL AREA 100 PPM SPECIAL 07 28 01 7: 44 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 11 01 8: 00 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 25 01 7: 49 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 26 01 7: 33 P DRIED YELLOW MATERIAL UROGENITAL AREA 69431 F 100 PPM SPECIAL 07 21 01 8: 24 P WET YELLOW MATERIAL UROGENITAL AREA 07 28 01 7: 44 P WET YELLOW MATERIAL UROGENITAL AREA 07 29 01 I: 36 P WET YELLOW MATERIAL UROGENITAL AREA _____________________________________

GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PCRDv4.04 11/ 28/ 2001 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE NON EXPOSURE DAYS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 1 TABLE RANGE: 05 31 01 TO 08 30 01 ____________________________________~~ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ___________

69306 M 0 PPM EYES/ EARS/ NOSE 69310 M 0 PPM SPECIAL 69314 M 0 PPM EYES/ EARS/ NOSE 69314 M 0 PPM EXCRETA 69317 M 0 PPM EYES/ EARS/ NOSE 69343 M 0 PPM EYES/ EARS/ NOSE 69343 M 0 PPM SPECIAL oy 69323 M 15 PPM EYES/ EARS/ NOSE ch 69335 M 15 PPM 5 EYES/ EARS/ NOSE 69338 M 15 PPM EYES/ EARS/ NOSE 07 31 01 14: 42 P 07 31 01 14: 42 P 08 01 01 14: 35 P 07 30 01 14: 42 P 07 09 01 14: 36 P 07 20 01 14: 18 P 07 30 01 14: 48 P 07 31 01 14: 41 P 07 31 01 14: 41 P 08 10 01 15: 29 P 07 09 01 14: 36 P DRIED RED MATERIAL AROUND RIGHT EYE RED NASAL DISCHARGE RED DISCHARGE RIGHT EYE DRIED BROWN MATERIAL ANOGENITAL AREA DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE RED DISCHARGE LEFT EYE CLEAR DISCHARGE RIGHT EYE CLEAR DISCHARGE LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE SOFT FECES 06 21 01 15: 15 P WET RED MATERIAL AROUND LEFT EYE 08 17 01 14: 44 P DRIED RED MATERIAL AROUND RIGHT EYE 08 17 01 14: 44 P DRIED RED MATERIAL AROUND LEFT EYE 08 13 01 14: 52 P WET YELLOW MATERIAL UROGENITAL AREA 08 14 01 14: 48 P WET YELLOW MATERIAL UROGENITAL AREA 08 17 01 14: 44 P WET YELLOW MATERIAL UROGENITAL AREA 08 17 01 14: 44 P WET YELLOW ANOGENITAL AREA 08 01 01 14: 39 P DRIED RED MATERIAL AROUND LEFT EYE 06 15 01 15: 21 P DRIED RED MATERIAL AROUND NOSE 06 29 01 13: 56 P DRIED RED MATERIAL AROUND LEFT EYE 07 04 01 13: 56 P DRIED RED MATERIAL AROUND LEFT EYE 07 20 01 14: 18 P RED DISCHARGE LEFT EYE 08 06 01 15: 08 P CLEAR DISCHARGE LEFT EYE 08 06 01 15: 08 P DRIED RED MATERIAL AROUND LEFT EYE 08 09 01 14: 45 P DRIED RED MATERIAL AROUND LEFT EYE 08 09 01 14: 45 P RED DISCHARGE LEFT EYE 08 22 01 14: 43 P DRIED RED MATERIAL AROUND LEFT EYE _____________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT NON EXPOSURE DAYS PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 2 SPONSOR: HAP TASK FORCE INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 05 31 01 TO 08 30 01 ____________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ^__________ 69338 M 69313 M 69324 M 69304 M 69307 M % 69318 M CR 69329 M 15 PPM 40 PPM 40 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 0 PPM EYES/ EARS/ NOSE EYES/ EARS/ NOSE EYES/ EARS/ NOSE SPECIAL EYES/ EARS/ NOSE SPECIAL EYES/ EARS/ NOSE SPECIAL SPECIAL 08 24 01 15: 41 08 28 01 14: 29 08 03 01 14: 06 07 27 01 14: 13 08 06 01 15: 15 08 09 01 14: 56 08 28 01 14: 42 08 29 01 14: 20 08 30 01 14: 16 07 26 01 14: 39 07 27 01 14: ll 07 30 01 14: 44 07 30 01 14: 44 08 03 01 13: 57 08 03 01 13: 57 08 10 01 15: 25 08 10 01 15: 25 08 28 01 14: 41 08 29 01 14: 23 08 22 01 14: 55 08 23 01 14: 31 08 23 01 14: 31 08 29 01 14: 19 07 20 01 14: 25 08 28 01 14: 40 08 29 01 14: 25 08 29 01 14: 25 08 03 01 14: 00 07 31 01 14: 39 P P P P P P P P P P P P P P P P P P P P P P P P P P ,p P P DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE RED DISCHARGE LEFT EYE RED DISCHARGE LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND LEFT EYE WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA CLEAR DISCHARGE RIGHT EYE RED DISCHARGE RIGHT EYE DRIED RED MATERIAL AROUND RIGHT EYE RED DISCHARGE RIGHT EYE RED DISCHARGE RIGHT EYE DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND RIGHT EYE RED DISCHARGE RIGHT EYE DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND RIGHT EYE DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND LEFT EYE DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA 69332 M 69366 F ______________________________________

GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE NON EXPOSURE DAYS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 3 TABLE RANGE: 05 31 01 TO 08 30 01 _______________________________________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS _____________________________________ 69366 69367 69367 69378 69378 69384 69398 % 69416 m 69419 F 0 PPM SPECIAL F F F F 0 PPM SPECIAL 0 RPM SPECIAL 0 PPM EYES/ EARS/ NOSE 0 PPM SPECIAL 0 PPM 0 PPM 0 PPM EYES/ EARS/ NOSE SPECIAL SPECIAL 0 PPM SPECIAL 08 28 01 14: 25 P WET YELLOW MATERIAL UROGENITAL AREA 07 30 01 14: 46 P DRLED RED MATERIAL AROUND RIGHT EYE 08 29 01 14: 20 P RED DISCHARGE RIGHT EYE 07 13 01 14: 42 P DRIED YELLOW MATERIAL UROGENITAL AREA 07 30 01 14: 46 P WET YELLOW MATERIAL UROGENITAL AREA 08 02 01 15: 14 P WET YELLOW MATERIAL UROGENITAL AREA 08 22 01 14: 40 P WET YELLOW MATERIAL UROGENITAL AREA 08 28 01 14: 23 P WET YELLOW MATERIAL UROGENITAL AREA 08 02 01 15: ll P DRIED RED MATERIAL AROUND RIGHT EYE 08 02 01 15: ll P RED DISCHARGE RIGHT EYE 07 31 01 14: 39 P WET YELLOW MATERIAL UROGENITAL AREA 07 09 01 14: 34 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 28 01 14: 21 P DRIED YELLOW MATERIAL UROGENITAL AREA 07 30 01 14: 45 P WET YELLOW MATERIAL UROGENITAL AREA 07 31 01 14: 39 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 13 01 14: 50 P WET YELLOW MATERIAL UROGENITAL AREA 08 24 01 15: 45 P WET YELLOW MATERIAL URO# ENITAL AREA 08 28 01 14: 26 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 07 01 14: 45 P WET YELLOW MATERIAL UROGENITAL AREA 08 13 01 14: 50 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 17 01 14: 48 P WET YELLOW MATERIAL UROGENITAL AREA 08 22 01 14: 40 P WET YELLOW MATERIAL UROGENITAL AREA 08 28 01 14: 24 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 29 01 14: 20 P DRIED YELLOW MATERIAL UROGENITAL AREA 07 09 01 14: 34 P WET YELLOW MATERIAL UROGENITAL AREA 07 09 01 14: 34 P DRIED YELLOW MATERIAL UROGENITAL AREA 07 30 01 14: 50 P WET YELLOW MATERIAL UROGENITAL AREA 08 02 01 15: lO P DRIED YELLOW MATERIAL UROGENITAL AREA 08 06 01 15: 17 P DRIED YELLOW MATERIAL UROGENITAL AREA ______________________________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE NON EXPOSURE DAYS PO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 4 TABLE RANGE: 05 31 01 TO 08 30 01 ___________________________________~~ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS _________________________________ 69419 F 69432 F 0 PPM 69432 F 0 PPM 69432 F t z 69362 F CR 69362 F % ch s 69376 F 69376 F ___________ GRADE CODE: 1 SLIGHT 2 _  0 PPM 0 PPM 15 PPM 15 PPM 15 PPM 15 PPM SPECIAL BODY/ INTEGUMENT EYES/ EARS/ NOSE SPECIAL ORAL/ DENTAL SPECIAL EYES/ EARS/ NOSE SPECIAL 08 13 01 14: 49 P 08 22 01 14: 40 P 08 28 01 14: 26 P 08 16 01 15: oo P 08 16 01 15: oo P 08 16 01 15: OO P 08 17 01 14: 46 P 08 17 01 14: 46 P 07 30 01 14: 44 P 08 13 01 14: 53 P 08 16 01 15: oo P 08 16 01 15: oo P 08 16 01 15: oo P 08 17 01 14: 46 P 08 17 01 14: 46 P 08 22 01 14: 40 P 08 22 01 14: 43 P 07 20 01 14: 19 P 08 10 01 15: 20 P 08 23 01 14: 31 P 08 28 01 14: 31 P 08 22 01 14: 44 P 08 22 01 14: 44 P 07 13 01 14: 49 P 07 15 01 14: 53 P 07 30 01 14: 53 P 08 09 01 14: 47 P 08 10 01 15: 20 P 08 22 01 14: 44 P WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DERMAL ATONIA DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND LEFT EYE DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND LEFT EYE WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL HINDLIMB WET YELLOW ANOGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW ANOGENITAL. AREA DRIED YELLOW MATERIAL UROGENITAL AREA UPPER INCISORS MALALIGNED WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED RED MATERIAL AROUND RIGHT EYE DRIED RED MATERIAL AROUND LEFT EYE WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA ______________________________________ MODERATE 3  SEVERE P  PRESENT NON EXPOSURE DAYS PROJECT NO.: WIL 417002 PO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 5 SPONSOR: HAP TASK FORCE INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 05 31 01 TO 08 30 01 ___~___~_____~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS __________________ 69376 F 15 PPM SPECIAL 69382 F 15 PPM SPECIAL 69390 F 15 PPM SPECIAL 69393 F 15 PPM SPECIAL $ 69396 F 4 % 69409 F m 69413 F s 69435 F 69359 F .69359 F ____________ GRADE CODE: 1 15 PPM.

15 PPM 15 PPM 15 PPM 40 PPM 40 PPM SPECIAL SPECIAL SPECIAL SPECIAL EXCRETA SPECIAL SLIGHT 2  MODERATE 08 28 01 14: 32 08 02 01 15: lO 08 24 01 15: 41 08 28 01 14: 29 06 15 01 15: 15 07 04 01 13: 51 07 05 01 14: 22 07 09 01 14: 43 07 20 01 14: 20 08 28 01 14: 29 08 29 01 14: 32 08 02 01 15: 12 08 09 01 14: 44 OS 14 01 14: 44 08 22 01 14: 45 08 29 01 14: 27 08 22 01 14: 45 08 28 01 14: 31 07 09 01 14: 43 08 09 01 14: 43 08 10 01 15: 21 07 04 01 13: 57 07 09 01 14: 40 08 13 01 14: 43 08 22 01 14: 45 08 28 01 14: 30 07 11 01 14: 07 07 11 01 14: 07 .___________.

3  SEVERE P  PRESENT P P P P P P P P P P P P P P P P P P P P P P P P P P P P WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA SOFT FECES WET YELLOW MATERIAL UROGENITAL AREA ____________________________________ NON EXPOSURE DAYS PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 6 SPONSOR: HAP TASK FORCE INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 05 31 01 TO 08 30 01 ______________________________________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS _______________~ 69359 F 40 PPM SPECIAL 07 11 01 14 07 16 01 14 07 26 01 14 07 30 01 14 08 03 01 14 08 06 01 15 08 22 01 14 08 28 01 14 08 29 01 14 08 29 01 14 08 22 01 14 08 28 01 14 06 29 01 13 07 16 01 14 07 26 01 14 07 30 01 14 07 31 01 14 08 09 01 14 08 24 01 15 08 28 01 14 08 29 01 14 08 10 01 15 08 28 01 14 08 29 01 14 06 29 01 13 07 12 01 13 08 29 01 14 07 19 01 14 07 30 01 14 08 P 34 P 49 P 56 P 08 P 17 P 51 P 34 P 30 P 30 P 50 P 34 P 50 P 29 P 45 P 53 P 33 P 50 P 50 P 36 P 29 P 21 P 34 P 31 P 47 P 40 P 32 P 19 P 51 P WET BROWN MATERIAL ANOGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA RED DISCHARGE RIGHT EYE RED DISCHARGE LEFT EYE 69369 F 40 PPM 69380 F 40 PPM a s 69388 F ' 69394 F 40 PPM 40 PPM 69426 F 40 PPM 69428 F 40 PPM SPECIAL SPECIAL SPECIAL SPECIAL SPECIAL EYES/ EARS/ NOSE _______________________________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT NON EXPOSURE DAYS PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 7 SPONSOR: HAP TASK FORCE INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 05 31 01 TO 08 30 01 _____________________________________~~~~~~~~~~~~~

ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS __________________~ 69428 F 40 PPM EYES/ EARS/ NOSE 07 30 01 14: 51 08 03 01 14: 04 08 22 01 14: 53 08 29 01 14: 30 69428 F 40 PPM SPECIAL 07 30 01 14: 51 08 22 01 14: 53 08 29 01 14: 30 69433 F 40 PPM SPECIAL 07 11 01 14: 08 07 30 01 14: 54 07 30 01 14: 54 07 31 01 14: 35 08 03 01 14: 06 08 06 01 15: 17 08 22 01 14: 53 08 28 01 14: 35 08 29 01 14: 28 69436 F 40 PPM SPECIAL 06 29 01 13: 50 07 LO 01 14: 58 0, 07 27 01 07 19 01 14: 15 14: 14 (3 07 30 01 14: 53 G 07 31 01 14: 33 08 02 01 15: 19 08 03 01 14: 05 08 03 01 14: 05 08 06 01 15: 18 08 07 01 14: 48 08 09 01 14: 50 08 13 01 14: 43 P P P P P P P P P P P P P P P P P P P P P P P P P P P P P DRIED RED MATERIAL AROUND LEFT EYE RED DISCHARGE LEFT EYE RED DISCHARGE LEFT EYE RED DISCHARGE LEFT EYE WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA __________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE NON EXPOSURE DAYS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 8 TABLE RANGE: 05 31 01 TO 08 30 01 ____~ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ________________________________________ 69436 F 40 PPM SPECIAL 08 29 01 14: 29 P WET YELLOW MATERIAL UROGENITAL AREA 08 29 01 14: 29 P DRIED YELLOW MATERIAL UROGENITAL AREA 07 16 01 14: 26 P WET YELLOW MATERIAL UROGENITAL AREA 07 30 01 14: 49 P WET YELLOW MATERIAL UROGENITAL AREA 08 24 01 15: 49 P WET YELLOW MATERIAL UROGENITAL AREA 08 28 01 14: 43 P WET YELLOW MATERIAL UROGENITAL AREA 08 29 01 14: 22 P WET YELLOW MATERIAL UROGENITAL AREA 07 16 01 14: 25 P WET YELLOW MATERIAL UROGENITAL AREA 07 27 01 14: 09 P WET YELLOW MATERIAL UROGENITAL AREA 07 16 01 14: 21 P WET YELLOW MATERIAL UROGENITAL AREA 08 28 01 14: 39 P WET YELLOW MATERIAL UROGENITAL AREA 06 22 01 15: 31 P WET YELLOW MATERIAL UROGENITAL AREA 07 30 01 14: 45 P WET YELLOW MATERIAL UROGENITAL AREA 07 13 01 15: 08 P WET YELLOW MATERIAL UROGENITAL AREA 08 28 01 14: 43 P WET YELLOW MATERIAL UROGENITAL AREA 08 29 01 14: 21 P WET YELLOW MATERIAL UROGENITAL AREA 08 30 01 14: 16 P WET YELLOW MATERIAL UROGENITAL AREA 07 30 01 14: 48 P WET YELLOW MATERIAL UROGENITAL AREA 08 02 01 15: 22 P WET YELLOW MATERIAL UROGENITAL AREA 08 29 01 14: 20 P WET YELLOW MATERIAL UROGENITAL AREA 08 29 01 14: 20 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 30 01 14: 16 P WET YELLOW MATERIAL UROGENITAL AREA 08 23 01 14: 26 P DRIED RED MATERIAL AROUND LEFT EYE 08 09 01 15: 06 P WET YELLOW MATERIAL UROGENITAL AREA 08 23 01 14: 26 P DRIED YELLOW MATERIAL UROGENITAL AREA 08 28 01 14: 38 P WET YELLOW MATERIAL UROGENITAL AREA 08 29 01 14: 25 P WET YELLOW MATERIAL UROGENITAL AREA 08 30 01 14: 17 P DRIED YELLOW MATERIAL UROGENITAL AREA 06 25 01 14: lP P WET YELLOW MATERIAL UROGENITAL AREA 69375 F 69379 F 69383 F 69385 F 69392 F P g 69402 F % a G 69408 F 69408 F 69415 F 100 PPM SPECIAL 100 PPM 100 PPM 100 PPM 100 PPM SPECIAL SPECIAL SPECIAL SPECIAL 100 PPM SPECIAL 100 PPM 100 PPM EYES/ EARS/ NOSE SPECIAL 100 PPM SPECIAL ______________________________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE NON EXPOSURE DAYS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 9 TABLE RANGE: 05 31 01 TO 08 30 01 _______________~ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS _______________________________~~

69415 F 100 PPM SPECIAL 06 29 01 07 04 01 07 13 01 07 24 01 07 27 01 07 31 01 08 01 01 08 03 01 08 03 01 08 14 01 08 22 01 08 23 01 08 23 01 08 28 01 08 29 01 08 29 01 69427 F 100 PPM SPECIAL 07 16 01 07 19 01 rs, 07 26 01 07 30 01 a 08 01 01 G 08 03 01 08 09 01 08 22 01 08 23 01 08 28 01 08 29 01 69431 F 100 PPM SPECIAL 07 13 01 07 25 01 13: 47 P 13: 50 P 15: 09 P 14: 20 P 14: 12 P 14: 32 P 14: 49 P 13: 59 P 13: 59 P 14: 40 P 14: 58 P 14: 28 P 14: 28 P 14: 42 P 14: 23 P 14: 23 P 14: 25 P 14: 23 P 14: 37 P 14: 47 P 14: 46 P 14: Ol P 15: 04 P 14: 58 P 14: 30 P 14: 40 P 14: 20 P 15: lO P 14: 48 P WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL VENTRAL TRUNK WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE NON EXPOSURE DAYS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 10 TABLE RANGE: 05 31 01 TO 08 30 01 ______________________________________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ________________________________________,

69431 F 100 RPM SPECIAL 07 30 01 14: 43 P 08 02 01 15: 18 P 08 03 01 13: 56 P 08 13 01 14: 50 P 08 22 01 14: 58 P 08 23 01 14: 27 P 08 28 01 14: 40 P 08 29 01 14: 24 P GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT _ WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA DRIED YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA WET YELLOW MATERIAL UROGENITAL AREA _________________________________ WIL 4 17002 HAP Task Force APPENDIX I 1, 1,2 Trichloroethane Dispositions and Body Weights (Pharmacokinetic Groups)

493 of 619 PROJECT NO.: WIL 417002R SPONSOR: HAP TASK FORCE DISPOSITIONS FOR RATS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 1 TABLE RANGE: 06 25 01 TO 06 29 01 ______________________________________~ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ___________________________________~~~~ 69355 69357 69358 69360 69363 69364 69365 69368 69372 69373 69374 69386 69387 69389 69397 69399 69400 69401 0, 69403 69405 a 69406 s 69407 69410 69411 69412 69414 69418 69420 69421 F F F F F F F F F F F F F F F F F 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM 100 PPM DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION DISPOSITION 06 29 01 06 27 01 06 27 02 06 27 01 06 29 01 06 29 01 06 25 01 06 29 01 06 25 01 06 29 01 06 25 01 06 29 01 06 25 01 06 29 01 06 25 01 06 27 01 06 25 01 06 29 01 06 27 01 06 29 01 06 29 01 06 25 01 06 25 01 06 27 01 06 29 01 06 29 01 06 27 01 06 25 01 06 27 01 16: 00 4: oo 4: oo 4: oo 16: OO 16: OO 0: oo 18: OO 0: oo 18: OO 0: oo 18: 00 0: oo 18: 15 0: oo 6: 00 0: oo 18: 15 6: 00 18: 15 18: 17 0 : 00 0: oo 6: 00 18: 17 18: 17 6: 15 0: oo 6: 15 P EUTHANIZED FOR BLOOD COLLECTION P SCHEDULED NECROPSY INTERVAL 4 P SCHEDULED NECROPSY INTERVAL 4 P SCHEDULED NECROPSY INTERVAL 4 P EUTHANIZED FOR BLOOD COLLECTION P EUTHANIZED FOR BLOOD COLLECTION P SCHEDULED NECROPSY INTERVAL 4 P EUTHANIZED FOR BLOOD COLLECTION P SCHEDULED NECROPSY INTERVAL 4 P EUTHANIZED FOR BLOOD COLLECTION P SCHEDULED NECROPSY INTERVAL 4 P EUTHANIZED FOR BLOOD COLLECTION P SCHEDULED NECROPSY INTERVAL 4 P EUTHANIZED FOR BLOOD COLLECTION P SCHEDULED NECROPSY INTERVAL 4 P SCHEDULED NECROPSY INTERVAL 4 P SCHEDULED NECROPSY INTERVAL 4 P EUTHANIZED FOR BLOOD COLLECTION P SCHEDULED NECROPSY INTERVAL 4 P EUTHANIZED FOR BLOOD COLLECTION P EUTHANIZED FOR BLOOD COLLECTION P SCHEDULED NECROPSY INTERVAL 4 P SCHEDULED NECROPSY INTERVAL 4 P SCHEDULED NECROPSY INTERVAL 4 P EUTHANIZED FOR BLOOD COLLECTION P EUTHANIZED FOR BLOOD COLLECTION P SCHEDULED NECROPSY INTERVAL 4 P SCHEDULED NECROPSY INTERVAL 4 P SCHEDULED NECROPSY INTERVAL 4 ________________________________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT DISPOSITIONS FOR RATS PROJECT NO.: WIL 417002R 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE PAGE 2 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 06 25 01 TO 06 29 01 _____________________________________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ____________________________________~~~~

69422 F 100 PPM DISPOSITION 06 27 01 6: 15 P SCHEDULED NECROPSY INTERVAL 4 69423 F 100 PPM DISPOSITION 06 27 01 6: 17 P SCHEDULED NECROPSY INTERVAL 4 69424 F 100 PPM DISPOSITION 06 27 01 6: 17 P SCHEDULED NECROPSY INTERVAL 4 69425 F 100 PPM DISPOSITION 06 27 01 6: 17 P SCHEDULED NECROPSY INTERVAL 4 69429 F 100 PPM DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 69430 F 100 PPM DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 69434 F 100 PPM DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 ____________________________________

GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PCRDv4.04 01/ 04/ 2002 DISPOSITIONS FOR MICE PROJECT NO.: WIL 417002M 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 1 SPONSOR: HAP TASK FORCE INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 06 25 01 TO 06 29 01 ______________________________________ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS ______________________________________ 5204 5205 5206 5207 5209 5210 5212 5214 5215 5216 5217 5218 5219 5220 5221 % 5222 5224 OY 5225 % 5226 5221 m 5228 z 5229 5230 5231 5232 5234 5235 5236 5238 F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM F 100 PPM DISPOSITION 06 29 01 16: 00 P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 29 01 16: 00 P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 29 01 16: 00 P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 25 01 16: 05 P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 DISPOSITION 06 29 01 18: Ol P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 25 01 16: OS P EUTHANIZED FOR BLOOD COLLECTION DISPOSITLON 06 25 01 16: 05 P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 DISPOSITION 06 25 01 0: oo P SCHEDULED NECROPSY INTERVAL 4 DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 DISPOSITION 06 29 01 18: Ol P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 DISPOSITION 06 25 01 18: Ol P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 DISPOSITION 06 25 01 18: Ol P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 25 01 18: Ol P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 DISPOSITION 06 29 01 18: Ol P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 29 01 18: 15 P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 DISPOSITION 06 29 01 18: 15 P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 29 01 18: 15 P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 29 01 18: 15 P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 DISPOSITION 06 29 01 18: 20 P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 25 01 18: 17 P EUTHANIZED FOR BLOOD COLLECTION DISPOSITION 06 25 01 18: 17 P EUTHANIZED FOR BLOOD COLLECTION _______________________________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PROJECT NO.: WIL 417002M SPONSOR: HAP TASK FORCE DISPOSITIONS FOR MICE 90 DAY TNHAL. STUDY OF l., 1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL CLINICAL OBSERVATIONS PAGE 2 TABLE RANGE: 06 25 01 TO 06 29 01 ___________________________________^__~ ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS _______________________________________~ 5239 F 100 PPM DISPOSITION 06 25 01 18: 17 P EUTHANIZED FOR BLOOD COLLECTION 5240, F 100 PPM DISPOSITION 06 29 01 18: 20 P EUTHANIZED FOR BLOOD COLLECTION 5242 F 100 PPM DISPOSITION 06 29 01 18: 20 P EUTHANIZED FOR BLOOD COLLECTION 5245 F 100 PPM DISPOSITION 06 25 01 18: 17 P EUTHANIZED FOR BLOOD COLLECTION 5241 F 100 PPM DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 5248 F 100 PPM DISPOSITION 06 25 01 0: OO P SCHEDULED NECROPSY INTERVAL 4 5249 F 100 PPM DISPOSITION 06 25 01 18: 17 P EUTHANIZED FOR BLOOD COLLECTION _____________________________________ GRADE CODE: 1  SLIGHT 2  MODERATE 3  SEVERE P  PRESENT PCRDv4.04 01/ 04/ 2002 PROJECT NO.: WIL 417002R SPONSOR: HAP TASK FORCE ._ WEEK ___ ___ ANIMAL 69355 69357 69358 69360 69363 69364 69365 69368 69372 69373 69374 69386 69387 69389 69397 1 0 ______________

125. 129. 152. 165. 174. 117. 124. 143. 149. 160. 115. 124. 140. 150. 155. 124. 126. 135. 139. 146. 130. 141. 157. 168. 178. 126. 135. 146. 168. 164. 117. 123. 140. 149. 156. 127. 133. 146. 154. 158. 120. 122. 144. 153. 159. 134. 134. 142. 149. 152. 126. 128. 147. 158. 166. 124. 124. 124. 150. 164. 128. 131. 141. 152. 156. 120. 123. 133. 136. 137. 119. 130. 145. 158. 169. 123. 127. 145. 154. 159. 115. 125. 147. 164. 171. 119. 127. 148. 162. 170. 129. 137. 148. 162. 169. 116. 122. 137. 145. 150. 130. 132. 147. 156. 161. 122. 127. 141. 148. 155. 117. 122. 140. 149. 156. 128. 135. 147. 154. 160. 124. 128. 135. 140. 145. 135. 142. 153. 159. 144. 69399 69400 69401 % 69403 69405 ch 69406 5, 69407 69410 69411 69412 69414 BODY WEIGHTS FOR RATS 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHTS [Gl PAGE 1 FEMALE GROUP: 100 PPM 1 2 3 ______________________________________ BODY WEIGHTS FOR RATS PROJECT NO.: WIL 417002R VO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE INDIVIDUAL BODY WEIGHTS [Gl 1 ._____ ___ ___________ ANIMAL 69418 69420 69421 69422 69423 69424 69425 69429 69430 63434 115. 127. 123. 130. 137. 140. 121. 130. 141. 143. 129. 135. 136. 143. 128. 131. 119. 128. 126. 131. FEMALE GROUP: 100 PPM 1 2 3 ._____________~~~

141. 141. 149. 150. 153. 154. 161. 140. 143. 153. 150. 143. 158. 160. 157. 167. 169. 147. 156. 161. 162 148 162 171 164 176 180 149 163 170 PAGE 2 MEAN 125. 130. 145. 154. 161. S. D. 6.7 6.2 7.2 8.4 10.2 N 36 36 36 36 36 PBFTSv4.23 02/ 06/ 2002 PROJECT NO.: WIL 417002M BODY WEIGHTS FOR MICE PO DAY INHAL. STUDY OF 1.1.2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE INDIVIDUAL'BGDY WEIGHTS (GRAMS)

WEEK _____ ANIMAL 5204 5205 5206 5207 5209 5210 5212 5214 5215 5216 5217 5218 5219 5220 5221 __ 2 ____ 1 _________ 0 ______ FEMALE GROUP: 1 2 ________________ 100 PPM 3  _    _ _

NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 20.3 21.0 NA 21.2 22.5 NA 20.6 21.1 NA 20.8 22.3 NA 20.4 21.9 NA 20.7 22.2 NA 20.3 22.2 NA 20.9 22.5 NA 20.7 23.0 NA 19.5 21.2 NA 22.9 22.9 NA 20.8 23.1 NA 21.3 22.2 NA 21.0 22.8 NA 20.8 22.3 NA 21.7 22.6 NA 20.8 21.5 NA 20.3 21.7 NA 21.0 23.3 NA 21.0 22.6 NA 22.1 23.4 NA 20.4 21.8 NA 22.6 24.5 NA 21.0 21.9 NA 21.2 22.4 NA 22.1 23.4 NA 21.5 NA 23.1 NA 21.7 NA 22.5 NA 22.1 NA 22.6 NA 24.1 NA 22.2 NA 22.9 NA 21.7 NA 24.6 NA 23.2 NA 23.0 NA 23.2 NA 22.5 NA 23.2 NA 22.3 NA 21.7 NA 22.9 NA 22.5 NA 23.4 NA 21.9 NA 24.2 NA 21.9 NA 22.3 NA 23.8 5222 5224 5225 0 5226 ch 5227 ch 5228 5, 5229 5230 5231 5232 5234 NA = NOT APPLICABLE ____. PAGE 1 4 _____ c_ BODY WEIGHTS FOR MICE PROJECT NO.: WIL 417002M 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 2 SPONSOR: HAP TASK FORCE INDIVIDUAL BODY WEIGHTS (GRAMS)

WEEK ____________ ANIMAL 5235 5236 5238 5239 5240 5242 5245 5247 5248 5243 2 _    _

NA NA NA NA NA NA NA NA NA NA MEAN 21.1 22.4 22.8 S. D. 0.71 0.73 0.75 N 36 36 36 3 NA = NOT APPLICABLE z z 5, 1 0 FEMALE GROUP: 100 PPM 1 2 3 4 ._______

NA NA 21.3 22 3 NA NA 20.5 21 9 NA NA 21.6 22 7 NA NA 22.2 22 5 NA NA 22.0 23 0 NA NA 20.9 21 9 NA NA 21.0 21 6 NA NA 21.2 23 1 NA NA 21.7 22 9 NA NA 21.5 22 3 NA 22 7 NA 22 1 NA 23 3 NA 23 3 NA 22 7 NA 22 7 NA 22 9 NA 23 6 NA 22 2 NA 23 0 PBFTSv4.23 l. 1/ 28/ 2001 WIL 4 17002 HAP Task Force 1, 1,2 Trichloroethane APPENDIX J Ophthalmic Examination Report (David A. Wilkie, D. V. M., M. S., D. A. C. V. 0.)

502 of 619 Concluding Statement Pertaining to Ophthalmic Examinations Performed During Conduct of Study WIL 417002 Al1 findings observed during the ophthalmic examinations for the above mentioned study are typical in prevalence and appearance for the species and strain or breed of animals examined. There were no significant differences within or among dose groups or compared to the pretest ophthalmic examinations to suggest a test article related effect.

David A. Wilkie, D. V. M., MS. Diplomate A. C. V. O. ' Da&

Tl 230 503 of 619 WIL 4 17002 HAP Task Force 1, 1,2 Trichloroethane APPENDIX K Histopathology Report (Experimental Patholopy Laboratories, Inc).

504 of 619 EPL" EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

WIL RESEARCH LABORATORIES, INC. STUDY NUMBER WIL 417002 EPL PROJECT NUMBER 223 057 A BO DAY INHALATION TOXICITY STUDY OF 1, I, 2 TRICHLOROETHANE (1, 1, 2 TCE) IN RATS (WITH SATELLITE GROUPS FOR PHARMACOKINETIC EVALUATIONS IN RATS AND MICE)

PATHOLOGY REPORT Submitted by:

Experimental Pathology Laboratories, Inc. P. O. Box 474 Herndon, VA 20172 0474 (703) 471 7060 Submitted to:

WIL Research Laboratories, Inc. Ashland, OH 448059281 April 29, 2002 505 of 619 EPL" EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

TABLE OF CONTENTS PATHOLOGY SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

QUALITY ASSURANCE FINAL CERTIFICATION _............................._..........

SUMMARY INCIDENCE TABLES Males .._..... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ._ . . . . . . . . . . . . . . . . . . . . . ._ . . .

Females.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . _. . . . . . . . . _. . . . . . . . . . . . . . . . . . _. . . . . . .

HISTOPATHOLOGY INCIDENCE TABLES Males . . . . . . . . . .._ . . . . . . .._..... _. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .._.....

Females .._..... . . . . . . . . .._... . . . . . . .._. .._. . . . . . . . . . . . . . . . . . . ..,... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

CORRELATION OF GROSS AND MICROSCOPIC FINDINGS m 1 11 l l l 7 II I II 21 Males.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Females.. . . . . . . . . . . ._. . . . . . . . . . , . . . _. . . . . . . . . . _. . . . . _. . . . . . . . . _. . . . . . , . . . . . . . . . . . . . . . . . . _. . . . . . . . . . . Ill 1 Ill 5 506of619 PATHOLOGY SUMMARY 507 of 619 EPL" EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

Page 1 WIL RESEARCH LABORATORIES, INC. STUDY NUMBER WIL 417002 EPL PROJECT NUMBER 223 057 A 90 DAY INHALATION TOXICITY STUDY OF 1, 1,2 TRICHLOROETHANE (1, 1,2 TCE) IN RATS (WITH SATELLITE GROUPS FOR PHARMACOKINETIC EVALUATIONS IN RATS AND MICE)

PATHOLOGY SUMMARY The purpose of this study was to evaluate the subchronic toxicity of the test article, 1, 1, 2 Trichloroethane (1, 1, 2 TCE), when administered via inhalation to rats for go days. With the exception of one Group 2 female (69377),

all toxicity animals exposed to the test article at concentrations up to 100 ppm survived to the end of the study.

MATERIALS AND METHODS Four groups of male and female Fisher 344 CDF@( F 344) Crl: BR rats were studied using the following experimental design.

No. Group Male Female Level (ppm)

1. Filtered Air 10 10 0 2. Low 1 ,I ,2 TCE 10 10 15 3. Mid 1,1,2 TCE 10 10 40 4. High 1 ,I ,2 TCE 10 10 100 508 of 619 EPL" EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

Page 2 WIL Research Laboratories, Inc. Study Number WIL 417002 At the completion of the study interval, all surviving adult rats were euthanized, and necropsies performed by WIL Research Laboratories, Inc.

Tissues were collected by WIL Research Laboratories, Inc. and, except for eyes,

testes and epididymides, fixed in 10% neutral buffered formalin. Eyes were placed in Davidson's solution and testes and epididymides were fixed in Bouin's solution. After fixation, all tissues were sent to Experimental Pathology Laboratories, Inc (EPLe), where they were embedded in paraffin and made into hematoxylin and eosin stained sections on glass microscope slides. The following tissues were examined by light microscopy as available:

509 of 619 EPL" EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

Page 3 WIL Research Laboratories, Inc. Study Number WIL 417002 Adrenals Aorta Bone with marrow (sternum)

Brain (forebrain, midbrain, hindbrain)

Epididymides Eyes with optic nerves Exorbital lacrimal glands Gastrointestinal tract Esophagus Stomach Duodenum Jejunum Ileum Cecum Colon Rectum Harderian glands Heart Kidneys Larynx (Levels I III)

Liver Lungs (with bronchi) Lymph node (tracheobronchial and mediastinal)

Mammary gland (females only)

Nasal tissues [nasal turbinates (Levels I VI)]

Ovaries with oviducts Pancreas Parathyroids Peripheral nerve (sciatic)

Pituitary Prostate Salivary glands (mandibular)

Seminal vesicles Skeletal muscle (rectus femoris)

Skin Spinal cord (cervical, thoracic, lumbar)

Spleen Testes Thymus Thyroids Trachea Urinary bladder Uterus with vagina All gross lesions `= Three cross sections were examined in accordance with the method described by Renne'. b= Six cross sections of the nasal passages were examined in `accordance with the method described by Morgan*. Levels I VI, as indicated in the Histopathology Incidence Tables, corresponds to levels 2,5,9,1 I, 23 and 28 as described by Mery3.

All tissues required by protocol are presented in the Histopathology Incidence Tables. Microscopic findings for each tissue examined from each rat are listed in the Histopathology Incidence Tables. Microscopic changes were graded one to four depending on severity. Nongradable findings are listed as 510 of 619 EPLI 8 EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

Page 4 WlL Research Laboratories, inc. Study Number WIL 417002 present (P), missing tissues are listed as no section (N), and paired organs that are missing one of the pair are indicated by an "m." Incomplete (I) denotes tissues that were inadequately collected at necropsy and had an insufficient section available for evaluation. All findings for all animals are summarized by sex and treatment group in the Summary Incidence Tables, together with the total number of animals in each group for which tissues were examined. A tabulation of gross observations noted at necropsy with the corresponding microscopic change, if appropriate, is presented in the Correlation of Gross and Microscopic Findings tables. The entries in these tables were transcribed from the gross necropsy records provided by WIL Research Laboratories, inc.

RESULTS Except for one Group 2 female (69377) sacrificed in a moribund condition, all rats survived to the end of the study interval. Microscopic changes in the lumbar spinal cord (hemorrhage, myelomalacia) of this Group 2 female suggest that back trauma may have been the cause of the early sacrifice.

Except for the liver and nasal turbinates, no effects considered possibly related to test article (1, 1, Z ICE) exposure were noted in any tissues examined.

In the liver, hepatocellular vacuolization (minimal severity) interpreted as test article retated was observed in 5/ l 0 males and 1 O/ l 0 females from Group 4,

and in 3/ l 0 females each from Groups 2 and 3. The lesion was characterized by the presence of small vacuoles within the cytoplasm of the hepatocytes in a focal to multifocal distribution within the sections examined. In the case of the females, there was no apparent dose related increase in severity between the three exposure groups, nor any dose related increase in incidence between 511 of 619 EPL" EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

I Page 5 WIL Research Laboratories, Inc. Study Number WIL 417002 Groups 2 and 3. While special stains were not employed to identify the material in the vacuoles, their morphology was consistent with lipid accumulation.

In the nasal turbinates, several microscopic lesions interpreted as test article related were observed in males from Groups 3 and 4 and females from all dose groups. The incidences of these lesions are delineated in the following table:

Table 1 Incidence of Selected Microscopic Lesions in Nasal Turbinates Group/ Dose/ Sex 1 (Control) 2 (15 w N 3 (40 pw 4 4 (100 w N Lesion MFMFMFMF Atrophy, Olfactory Epithelium O/ lOa O/ IO O/ IO O/ IO 6110 7110 7110 IO/ IO (0/ 60) b (O/ 60) (O/ 60) (O/ 60) (8/ 60) (7160) (15/ 60) (13/ 60)

Vacuolization/ Cyst, Olfactory l/ IO l/ IO 2110 4/ 10 6/ 10 4/ 10 IO/ IO 8/ 10 Epithelium (l/ 60) (l/ 60) (2/ 60) (4/ 60) (1 I/ 60) (4/ 60) (15160) (12/ 60)

Respiratory Epithelial Metaplasia, O/ IO 0110 1110 0110 l/ IO l/ IO 3110 5/ 10 Olfactory Epithelium (O/ 60) (O/ 60) (l/ 60) (O/ 60) (2/ 60) (l/ 60) (3/ 60) (960) a = Number of animals affected/ number of animals examined b = Total number of individual sections affected/ total number individual sections examined Atrophy of the olfactory epithelium was characterized by a thinning of the olfactory epithelial mucosa primarily due to a reduction in the thickness of the nuclear cell layer. The lesions were generally observed in sections from Levels 3, 4, and 5, of minimal to mild severity, and focal in distribution, primarily affecting the epithelium of the nasal septum in the dorsal medial meatus. Occasionally,

there was a complete absence of the olfactory mucosa in the affected area. The 512 of 619 EPL" EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

Page 6 WIL Research Laboratories, Inc. Study Number WIL 417002 mechanism for the cell loss was not microscopically obvious; however, since the lesion was only observed in animals from Groups 3 and 4, it was interpreted as related to test article exposure. The focal nature of the lesion could not be explained.

Vacuolization and/ or microcyst formation in the olfactory epithelium was characterized by the presence of small focal to multifocal vacuoles/ microcysts within the basilar regions of the olfactory mucosa. Again, the most commonly affected area was the olfactory epithelium lining the dorsal medial meatus at Levels 2 through 5. Typically, the wall of these vacuoles/ cysts was devoid of any structure, but occasionally, they were lined by a cuboidal epithelium, which most resembled the epithelium of Bowman's glands. In general, the vacuoles were devoid of any content; however, occasionally an eosinophilic globular material was observed within. While the change was also observed in one control male and female, the incidence of animals affected and levels per animal affected generally increased with exposure to increasing concentrations of the test article.

Although the pathogenesis of the lesion was not apparent, the character of the lesion suggests that it is probably degenerative in nature. Whether exposure to the test article directly induced the formation of these vacuoles/ cysts or secondarily accelerated a process that is normally present within the nasal olfactory mucosa could not be determined.

Respiratory epithelial metaplasia of the olfactory epithelium was observed in males from Groups 2, 3, and 4 and females from Groups 3 and 4 and characterized by the presence of focal areas wherein the olfactory epithelium underwent metaplastic change to respiratory epithelium. Again, these changes were only observed in the olfactory epithelium lining the dorsal medial meatus at Levels 4 and 5. Although one Group 2 male (69335) also was affected, the 513 of 619 EPL" EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

Page 7 WIL Research Laboratories, Inc. Study Number WIL 417002 lesion in this animal was considered incidental and not related to test article exposure since it was associated with inflammation within the nasal cavity interpreted as spontaneous in origin. Respiratory epithelial metaplasia is commonly considered to be a sequela to atrophy and degeneration of the olfactory epithelium with replacement by ciliated and non ciliated respiratory epithelium. It may be seen as a spontaneous focal lesion in aged rats4. Whether test article exposure directly induced this change or accelerated the normal aging process could not be determined.

Additional microscopic findings (described below) noted in rats from control and treated groups included mononuclear cell infiltrates in various tissues, granulomatous inflammation in the larynx and trachea, and mineralization or mineral deposition in the kidney, larynx, nasal turbinates, and cornea of the eye. In general, there were no significant differences in the incidence of these lesions between control and treated groups. Therefore, they were considered incidental and unrelated to test article (I, 1, 2 TCE)

administration.

Mononuclear cell infiltrates, observed in various tissues, typically consisted of foci of lymphocytes and plasma cells generally accompanied by a few neutrophils as a minor component. This morphology is consistent with subacute inflammation.

Granulomatous inflammation was observed in the larynx at all three levels examined. The lesion was characterized by the presence of histiocytes and an occasional multinucleated giant cell forming discrete focal microgranulomas surrounding a mineralized center located just below the mucosal epithelial layer.

Similar lesions were also occasionally observed in the trachea. This lesion is typically observed as a response to a penetrating foreign body, and its location 514 of 619 EPL" EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

Page 8 WIL Research Laboratories, Inc. Study Number WIL 417002 suggests that it may have resulted from the penetration of food material aspirated into the larynx and trachea. However, any such material, if present in the mineralized core, could not be identified.

Mineralization in the kidney of both control and treated male and female rats was characterized by the accumulation of lightly to intensely staining basophilic material within the lumina of the renal tubules. The mineral deposition observed in the larynx was located within the central core of the microgranulomas, as already discussed. These changes were considered incidental and not related to treatment.

Mineral deposition in the nasal turbinates was observed in sections from Levels 2 through 6 of both control and treated male and female rats. This lesion was characterized by the deposition of basophilic material just underlying the epithelium of the transitional, respiratory, and olfactory mucosae. In some cases,

the mineral could be localized to the basement membrane. Similar deposits associated with the basement membrane of the respiratory and olfactory mucosae have been reported to increase in frequency with age*.

Mineral deposition within the cornea of the eye was characterized by the presence of lightly staining basophilic material within lamina propria of the cornea just underlying the cornea1 epithelium. The lesion was focal in distribution,

typically located in the central region of the cornea, and of minimal severity. The pathogenesis of this lesion was not determined. However, since the incidence was not significantly different between controls and treated rats, it was considered incidental and not related to treatment.

515 of 619 EPL" EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

Page 9 WIL Research Laboratories, Inc. Study Number WIL 417002 CONCLUSIONS AND SUMMARY Except for the liver and nasal turbinates, no effects considered possibly related to test article (1, 1,2 TCE) exposure were noted in any tissues examined.

In the liver,` hepatocellular vacuolization interpreted as test article related was observed in 5/ l 0 males and 1 O/ l 0 females from Group 4, and in 3/ l 0 females each from Groups 2 and 3. In the nasal turbinates, several microscopic lesions interpreted as test article related were observed in males from Groups 3 and 4 and females from all dose groups. These lesions included atrophy of the olfactory epithelium, vacuolization/ cyst formation within the olfactory mucosa,

and respiratory epithelial metaplasia of olfactory epithelium. The few other changes in various tissues of male and females rats from control and treated groups were considered incidental and unrelated to test article (1, 1, 2 TCE)

exposure.

FREDERICK A. RUECKER, DVM, MS, Diplomate, ACVP Veterinary Pathologist FARfwk I/

516of619 EPL" EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

Page 10 WIL Research Laboratories, Inc. Study Number WIL 417002 REFERENCES 1. Renne, R. A.. Gideon, K. M., Miller, R. A., Mellick, P. W., and Grumbein, S. L. (1992). Histologic methods and interspecies variations in the laryngeal histology of F344/ N rats and B6C3Fl mice. Toxicol. Pafhol. 20, No. 1,44 51.

2. Morgan, K. (1991). Approaches to the identification and recording of nasal lesions in toxicology studies. Toxicol. Pafhol. 19, No. 4 (Part I), 337 35 1.

3. Mery, S., Gross, E. A., Joyner, D. R., Godo, M., and Morgan, K. T. (1994). Nasal diagrams: A tool for recording the distribution of nasal lesions in rats and mice. Toxicol. Pafhol. 22, No. 4, 353 372.

4. Greaves, P. Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation, 2" d ed., p 211. Elsevier Science, Amsterdam, The Netherlands, 2000.

517 of 619 I EXPERIMENTAL PATHOLOGY LABORATORIES, INC.

Page 11 QUALITY ASSURANCE FINAL CERTIFICATION Study Title: A QO Day Inhalation Toxicity Study of 1 ,I ,BTrichloroethane (1,1,2 TCE) in Rats (with Satellite Groups for Pharmacokinetic Evaluations in Rats and Mice)

Client Study: WIL 417002 EPL Project Coordinator: Nelson Wilson EPL Project Number: 223 057 EPL Pathologist: Dr. Frederick Ruecker The following aspects of this study were inspected by the Quality Assurance Unit of Experimental Pathology Laboratories, Inc. Dates inspections were performed and findings reported to the EPL Project Coordinator and Management are indicated below.

Area Inspected inspection Dates Reporting EPL Project Sheets Project Setup Q/ 4/ 01; Q/ 19/ 01; 12/ 5/ 01 914/ 01; Q/ 19/ 01; 12/ 5/ 01 9113/ 01; l/ 2102 9/ l 3iOl; l/ 2/ 02 Histology Setup 9/ l 9101 9/ l 9101 Data Review Draft Report Final Report 10/ 12,18,25/ 01 10/ 12,18,25/ 01 I/ 2, 3102 I f3lO2 4/ 29/ 02 4/ 29/ 02 Date reported to Study Director/ Management 4/ 29/ 02 Date of last quarterly facility inspection 4/ 02 /" 5%= 2& / kwLL;~~ EPL Quality Assurance Unit Y . dq a2 Date Form No. 6 2 (7/ 2/ 99)

518of619 SUMMARY INCIDENCE TABLES 519of619 SUMMARY INCIDENCE TABLE WIL 417002 90 Day Sacrifice Male Rat EPL( I 1 Experimental Pathology Laboratories, Inc.

520 of 619 SUMMARY INCIDENCE TABLE WIL 417002 go Day Sacrifice Male Rat Mineral Deposition I 4 9 )

EPL/ l 2 Experimental Pathology Laboratories, Inc.

521 of 619 SUMMARY INCIDENCE TABLE WIL 417002 BO Day Sacrifice Male Rat / LIVER (NO. EXAMINED)

Degeneration/ Necrosis,

Hepatocytes Hyperplasia, Bile Ducts ~ ~ GROUP GROUP GROUP GROUP 2 _~ (la, 3 4 (10) (10) (10)

1 infiltrate, Mononuclear Cell Vacuolization, Hepatocytes ( ) 10 LUNG W/ BRONCHI NO. EXAMINED (10) ( ) (10) (10)

Alveolitis/ lnterstital Pneumonia 1 1 Hemorrhage LYMPH NODE, MEDlASTlNAL (NO. EXAMINED)

Congestion/ Hemorrhage (9) (1) (10) 2 1 LYMPH NODE, TRACHEOBRONCHIAL (NO. EXAMINED)

Congestion/ Hemorrhage (9) (7) 2 NASAL TURBINATE, LEVEL I (NO. EXAMINED)

Hyperplasia, Squamous Epithelium Hyperplasia, Transitional Epithelium NASAL TURBINATE, LEVEL II (NO. EXAMINED) (10) (10) (10) (10) ,$, trate b" ,.*^^..^ I^^ rP^ rI 1 Inflnmmnt c L LJ" LL inflammatory Cell Exudate,

Medial Meatus Mineral Deposition VacuolizatioKyst, Olfactory Epithelium L .I 1 1 1 9 10 8 9 1 2 2 8 EPLl l 3 Experimental Pathology Laboratories, Inc.

522of619 SUMMARY INCIDENCE TABLE WIL 417002 90 Day Sacrifice Male Rat EPL\ l 4 Experimental Pathology Laboratories, Inc.

523 of 619 WIL 417002 9C Day Sacrifice Male Rat SUMMARY INCIDENCE TABLE j GROUP 1 GROUP j GROUP 1 GROUP (

NASAL TURBINATE, LEVEL VI (NO.

EXAMINED)

Atrophy, Olfactory Epithelium Infiltrate, Mononuclear Cell Mineral Deposition 1 2 3 4 (10) (10) (10) (10)

2 1 8 9 10 IO I I I I I PARATHYROID (NO. EXAMINED) / (10) / ) (10) 1 I I /

PERIPHERAL NERVE (SCIATIC) (NO.

EXAMINED) (10) (10)

PITUITARY (NO. EXAMINED) (10) (10) Hypertrophy, Pars Distalis 1 PROSTATE (NO. EXAMINED)

Atrophy, Acinar Epithelium Hyperplasia, Acinar Epithelium Infiltrate, Mononuclear Cell (10) (10) 1 1 2 SALIVARY GLAND, MANDIBULAR (NO.

EXAMINED) (10) (10)

SKIN (NO. EXAMINED) (10) (10)

Inflammation, 1 SPINAL CORD, CERVICAL (NO.

EXAMINED) (10) (10)

EPLl l 5 Experimental Pathology Laboratories, Inc.

524 of 619 SUMMARY INCIDENCE TABLE WIL 417002 90 Day Sacrifice Male Rat / I SPLEEN (NO. EXAMINED) I (10) I (1) I (1O) L I Accessory Tissue 1 1 Increased Hematopoiesis 1 TRACHEA (NO. EXAMINED) (10) (10) (10) (10)

Infiltrate, Mononuclear Cell 2 1 3 3 Inflammation, Granulomatous 1 2 1 Mineral Deposition 1 2 1 EPLI ) Experimental Pathology Laboratories, Inc. l 6 525 of 619 SUMMARY INCIDENCE TABLE WIL 417002 90 Day Sacrifice Female Rat 1 GROUP GROUP j GROUP 1 GROUP /

Proteinaceous Fluid,

Intraocular 1 d 1 Retinal Dysplasia I I I I ,

HARDERIAN GLAND (NO. EXAMINED) 1 (10) I (1) I 1 (10) /

EPLI l 7 Experimental Pathology Laboratories, Inc.

526 of 619 SUMMARY INCIDENCE TABLE WIL 417002 SO Day Sacrifice Female Rat EPLl 1 8 Experimental Pathology Laboratories, Inc.

527of619 SUMMARY INCIDENCE WIL 417002 OO Day Sacrifice Female Rat LIVER (CONTINUED)

Infiltrate, Mononuclear Cell Vacuolizetion, Hepatocytes GROUP GROUP GROUP GROUP 1 2 3 4 6 8 9 9 3 3 10 TABLE LUNG W/ BRONCHI (NO. EXAMINED)

Alveolitis/ lnterstital Pneumonia Hemorrhage (10) (10) (10) (IO)

2 1 1 1 LYMPH NODE, MANDlBUViR (NO. EXAMINED) (1) (1) Congestion/ Hemorrhage 1 1 1 (IO) I I I I MAMMARY GLAND (NO. EXAMINED) , I (IO) I I I I I i EPLl l 9 Experimental Pathology Laboratories, Inc.

528 of 619 SUMMARY INCIDENCE TABLE WlL 417002 OO Day Sacrifice Female Rat / GROUP j GROUP ) GROUP ) GROUP ) 1 1 1 1 2 / 3 j 4 1 .... .. .. ~. NASAL TUKBINATE, LEVEL Ill (NO. I I EXAMINED) I (10) I (10) I _( lQ I (IO) I 3 ( I I I I I I I I I 1 I I I I I 1 I I ! I I 3 )

I I I I I i I I 1 2 3 2 2 Epithelium 1 1 1 2 5 Atrophy, Olfactory Epithelium Degeneration, Respiratory Epithelium Infiltrate, Mononuclear Cell inflammation Inflammation, Nasolacrimal Duct Inflammatory Cell Exudate, Medial Meatus Mineral Deposition VacuolizationlCyst, Olfar$ ory NASAL TURBINATE. LEVEL IV (NO. I I I I I I EXAMINED)

Atro[ ,.&,+ r I I I I (` 0) ! (10) I (10) I (IO) I lhy, Olfactory Epithelium II 111111 ate, Mononuclear Cell Inflammation, Nasolacrimal Duct 3 3 1 Mineral Deposition Resniratorv Enithelinl Metaplasia, Olfactory Epithelium Squamous Metaplasia,

Respiratory Epithelium VacuolizationlCyst. Olfactory Epithelium I I I 1 9 I I /

I I 9 1 IO ( 10 1 I I I I 1 3 1 1 NASAL TURBINATE, LEVEL V (NO.

EXAMINED) (10) (IOL (10) (10)

1 7 I Atrophy, Olfactory Epfthelium Infiltrate, Mononuclear Cell Inflammatory Cell Exudate,

Medial Meatus Mineral Deposition Respiratory Epithelial Metaplasia, Olfactory Epithelium I I ! ! I  L 1 1 10 EPL] I ICI Experimental Pathology Laboratories, Inc.

529 of 619 SUMMARY INCIDENCE TABLE WIL 417002 90 Day Sacrifice Female Rat EPLI l l 1 Experimental Pathology Laboratories, Inc.

530 of 619 SUMMARY INCIDENCE TABLE WIL 417002 90 Day Sacrifice Female Rat EPLl l 12 Experimental Pathology Laboratories, inc.

531 of 619 HISTOPATHOLOGY INCIDENCE TABLES 532 of 619 HISTOPATHOLOGY INCIDENCE TABLE GROUP

6 9 3 1 L I h

h h c c I

I

c

7 I_

7 i WIL 417002 90 Day Sacrifice Male Rat

6 9 3 0 6 z h

c c z c c

c

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6 3" 2 2 x

x

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                                 I I n ADRENAL Vacuolization, Cortex L 1 J

:

:

r E AORTA X Inflammatory Cell Infiltrate, Adjacent Brown Fat BONE MARROW, STERNUM X BONE. STERNUM X BRAIN X EPIDIDYMIS X ESOPHAGUS X I FVF T *IL Hyperplasia, Cornea! Epithelium Inflammation, Cornea Mineralization, Cornea Proteinaceous Fluid, Intraocular Retinal Atrophy Retinal Dysplasia HEART Myocardial Degeneration 1 INTESTINE LARGE, CECUM X Inflammation INTESTINE LARGE, COLON X t EPL/ II 1 Experimental Pathology Laboratories, Inc. Key: X= Not Remarkable N= No Section Hncomplete A= Autolysis l= minimal P= mild Bcmoderate 4= severe P= Present B= Benign M= Malignant m= missing one paired organ u= unscheduled sac./ deatn 533 of 619 HISTOPATHOLOGY INCIDENCE TABLE GROUP WIL 417002 go Day Sacrifice Male Rat A N I M A L 2 INTESTINE LARGE, RECTUM X Inflammation Nematode Parasite, Lumen INTESTINE SMALL, DUODENUM x INTESTINE SMALL, ILEUM X INTESTINE SMALL, JEJUNUM X I LACRIMAL GLAND (EXORBITAL) IX /

EPL(

Experimental Pathology Laboratories, Inc. 6 6 9 9 ; i 68 pP x x xx xx 2 2 1_ 1 x x 1 1 11 I 3 1 1 X l

:

II 2 6 6 6 6 9 9 9 9 Key: X Not Remarkable N= No Section I= lncomplete A Autolysis l= minimal P= mild 3= moderate 4= severe PEPresent &Benign M= Malignant m= missing one paired organ u= unscheduied sac/ death 534 of 619  HISTOPATHOLOGY INCIDENCE TABLE WIL 417002 QO Day Sacrifice Male Rat A N LIVER Degeneration/ Necrosis, Hepatocytes Hyperplasia, Bile Ducts Infiltrate, Mononuclear Cell Vacuolization, Hepatwytes LUNG W/ BRONCHI Alveolitis/ lnterstitial Pneumonia Hemorrhage LYMPH NODE, MEDlASTlNAL _ Congestion/ Hemorrhage NASAL TURBINATE, LEVEL II Infiltrate, Mononuclear Cell Inflammation, Nasolacrimal Duct Inflammatory Cell Exudate, Medial Meatus Mineral Deposition VacuolizationKyst, Olfactory Epithelium

6 9 3 0 2

I I

z

23

x

x

I z    I I i I I I

: 3 2 2

z

x

z

h

I

z     L EPLI II 3 Experimental Pathology Laboratories, Inc. Key. X= Noi Remarkable N= No Section l= lncomplete A= Autolysis l= minimal2= mtid B= modeiate 4= severe P= Present B Benign M= Malignant m= missing one paired organ u= unscheduled sac./ death 535 of 619 HISTOPATHOLOGY INCIDENCE TABLE GROUP WIL 417002 QO Day Sacrifice Male Rat A N :: L Duct Inflammatory Cell Exudate, Medial Meatus Mineral Deposition Vacuolization/ Cyst, Olfactory Epithelium NASAL TURBINATE, LEVEL IV Atrophy, Olfactory Epithelium Infiltrate, Mononuclear Cell Inflammation, Nasolacrimal Duct Mineral Deposition Respiratory Epithelial Metaplasia, Olfactory Epithelium Squamous Metaplasia, Respiratory Epithelium VacuolizationlCyst, Olfactory Epithelium NASAL TURBINATE, LEVEL V Atrophy, Olfactory Epithelium Infiltrate, Mononuclear Cell Inflammatory Cell Exudate, Medial Meatus Mineral Deposition Respiratory Epithelial Metaplasia, Olfactory Epithelium VacuolizationlCyst. Olfactory Epithelium 6 9 3 0 2

1

I

^

EPLl II 4

i Experimental Pathology Laboratories, inc. L i Key: X= Not Remarkable N= No Section I= lncomplete A= Autolysis l= minimal 2= mild J= moderate 4= severe P= Present B= Benign M= Malignant m= missing one paired organ u= unscheduled sacldeath 536 of 619 HISTOPATHOLOGY INCIDENCE TABLE WIL 417002 BO Day Sacrifice Male Rat GROUP 1 33333333j3 0001111234 2680247273 x x EPL(

Experimental Pathology Laboratories, inc. II 5 Key, X= Not Remarkable N= No Section I= lncomplete A= Autotysis l= minimal * mild 3= moderate 4= severe P= Present B= Benign M= Malignant m= misslng one paired organ u= unscheduled sac/ death 537 of 619 HISTOPATHOLOGY INCIDENCE TABLE WIL 417002 90 Day Sacrifice Male Rat _STOMACH Edema, Nonglandular Hyperplasia, Squamous Epithelium, Nonglandular Inflammation, Nonglandular TESTIS THYMUS Congestion Necrosis, Cortical Lymphocytes THYROID URINARY BLADDER Infiltrate, Mononuclear Cell EPLl II 6 Experimental Pathology Laboratories, Inc. GROUP

E 3 :

"

n 4

?I

h 2

3

z

n           6 9 3 1 4 x

h h

h

xc x

x x

x

Key: X= Nol Remarkable N= No Section t= lncomptete A= Autolysis t= minimal P= mild B= moderate 4= sevwe P Present B= Benign M= Malagnant mwwsing one paired organ u= unscheduled sac./ death 538 of 619 . HISTOPATHOLOGY INCIDENCE TABLE GROUP 9 WIL 417002 go Day Sacrifice Male Rat KIDNEY Inflammation, Pelvis Mineralization Nephropathy 5 6 1 1 1 infiltrate Mononuclear Cell ~

Infiltrate, Mononuclear Cell ~

LIVER D% eneration/ Necrosis, Hepatocytes Hyperplasia, Bile Ducts Infiltrate, Mononuclear Cell 1 1 Vacuolization, Hepatocytes EPL] II 7

6 9 3 2 0

z

i 3

3

I

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542 of 619 HISTOPATHOLOGY INCIDENCE TABLE GROUP WIL 417002 90 Day Sacrifice Male Rat LARYNX, LEVEL II Hvperplasia, Transitional Epithelium Infiltrate, Mononuclear Cell 1 Inflammation, Granulomatous Inflammatory Cell Exudate, Lumen Mineral Deposition Squamous Metaplasia, Transitional Epithelium Lumen Mineral Deposition LIVER Degeneration/ Necrosis, Hepatocytes Hyperplasia, Bile Ducts Infiltrate, Mononuclear Cell Vacuolization, Hepatocytes 1 LUNG W/ BRONCHI Alveolitis/ lnterstitial Pneumonia Hemorrhage X

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545 of 619 HISTOPATHOLOGY INCIDENCE TABLE GROUP

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EPLj II 15 Experimental Pathology Laboratories, Inc. Key: X= Not Remarkable N= No Section I= lncomplete A= Autolysis I= minimai P= mild 3= moderale 4= severe P= Present B= Benign M= Makgnant m= missing one paired organ u unscheduled %x./ death i 547of619 HISTOPATHOLOGY INCIDENCE TABLE GROUP WIL 417002 go Day Sacrifice Male Rat A N M A L r INTESTINE LARGE, RECTUM Inflammation Nematode Parasite, Lumen INTESTINE SMALL, DUODENUM X INTESTINE SMALL, ILEUM X INTESTINE SMALL, JEJUNUM X KIDNEY Inflammation, Pelvis Mineralization 1 Nephropathy 1 I LACRIMAL GLAND (EXORBITAL) IX LARYNX, LEVEL I X infiltrate, Mononuclear Cell Inflammation, Granulomatous Mineral Deposition Lumen I Mineral Deposition I 1 EPLl x x % x x x x 1 2 x x I X 1 2 1 1 1 $ 1 s 1 1 =t 1 Experimental Pathology Laboratories, Inc. II 16

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