  SEQ CHAPTER \h \r 1

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

DATE:  	11-FEB-2008

SUBJECT:	Pyraclostrobin. Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessments to Support New Use on Oat Grain, Barley Grain, Oilseed (Crop Group 20), Fresh Herbs (Herbs Subgroup 19A), Avocado, Black Sapote, Canistel, Mamey Sapote, Mango, Papaya, Sapodilla, and Star Apple

PC Code:	099100		Decision Number: 370224

DP Number:	348308

REVIEWER:	Sheila Piper, Chemist

Alternative Risk Integration Assessment Team (ARIA)

Risk Integration, Minor Use and Emergency Response (RIMUER) Branch

Registration Division (7505P)

THROUGH:	Douglas Dotson, Chemist

Felecia Fort, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

		John Redden, Team Leader

ARIA/Registration Division (7505P)

TO:		Barry O’Keefe, Risk Assessor

		Registration Action Branch 3

		Health Effects Division (7509P)

		Barbara Madden PM-5

		Risk Integration Minor Use, and Emergency Response Branch

		Registration Division (7505P)

Executive Summary

odel (DEEM-FCID™, Version 2.03), which uses food consumption data from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. The analyses were performed as part of a registration action; (1) to support BASF requests for tolerances for new uses in/on oats and oilseed (Crop Group 20); (2) to support a petition for tolerances in conjunction with an Interregional Research Project No. 4 (IR-4) petition for the new uses in/on fresh herbs (Herbs Subgroup 19A), avocado, black sapote, canistel, mamey sapote, mango, papaya, sapodilla, star apple and increased tolerance on barley; and (3) to include drinking water estimates reflecting the new uses.

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

The acute dietary exposure analysis used tolerance level residues or highest residues and 100% crop treated for all registered and proposed uses. Experimentally derived processing factors were used for fruit juices, tomato and wheat commodities; as well as default processing factors.  For all other processed commodities, DEEM default processing factors were assumed. Two acute population adjusted doses (aPADs) were established for pyraclostrobin.  The developmental toxicity study for prenatal rabbit showed the lowest observable adverse effect level (LOAEL) of 10 mg/kg/day based on increased resorptions and will be used for females 13-49 yrs.  The neurotoxicity study in rats showed a LOAEL of 1000 mg/kg/day based on decreased body weight gain in male rats and will be used for the general population, including infants and children. The estimated acute drinking water concentration for pyraclostrobin was calculated based on a maximum application rate of 3.0 lb ai/A/season and in surface water is not likely to exceed 35.6 ppb for the peak concentration.

The results of the acute dietary analysis for food and water indicate that acute dietary risks do not exceed the Agency’s level of concern (< 100% of the aPAD) for the U.S. population and all subgroups.  Combined dietary from food and drinking water at the 95th percentile of exposure is estimated to be 0.043307 mg/kg/day for the overall U.S. population, equivalent to 1% of the acute Population Adjusted Dose (aPAD).  The population subgroup with the highest estimated acute dietary exposure to pyraclostrobin is females 13-49 years, with an estimated exposure at the 95th percentile of 0.040151 mg/kg/day, equivalent to 80% of the aPAD.

Chronic Dietary (Food and Drinking Water)Exposure Results and Characterization

The chronic dietary analysis included tolerance level or average residues from field trial data and 100% crop treated assumptions for all commodities.  Experimentally derived processing factors were used for fruit juices, tomato and wheat commodities.  For all other processed commodities, DEEM default processing factors were assumed. The rat carcinogenicity study findings are used for endpoint selection for chronic dietary based on findings of decreased body weight/gain and kidney tubular casts/atrophy in both sexes in addition to liver necrosis and stomach lesions in males at the high dose (LOAEL) of 9.2 mg/kg/day.  This study has the lowest NOAEL (3.4 mg/kg/day) in the most sensitive species following chronic exposure.  The estimated surface water concentration was incorporated directly into the dietary assessment using the 1-in-10 yr annual mean (2.3 ppb) for surface water.

The results of the chronic dietary analysis for food and drinking water are below the Agency’s level of concern (<100% cPAD) for all population subgroups. The dietary exposure is estimated at 0.006149 mg/kg/day for the general U.S. population (18% of the chronic Population Adjusted Dose (cPAD)) and 0.016427 mg/kg/day (48% of the cPAD) for children 1-2 yrs, the population subgroup with the highest estimated chronic dietary exposure to pyraclostrobin.

Cancer Dietary Exposure Results and Characterization

HED has determined that it is no longer appropriate to regulate cancer risk for pyraclostrobin using an MOE approach since the Cancer Assessment Review Committee (CARC) recently concluded that the chemical is “not likely to be carcinogenic to humans.”

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population adjusted dose (PAD).  The PAD is equivalent to the reference dose point of departure (POD, NOAEL, LOAEL) divided by the required uncertainty and safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  HED is generally concerned when estimated cancer risk exceeds one in one million (i.e., the risk exceeds 1 x 10-6).  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link:      HYPERLINK "http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf"  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see SOP 99.6 (8/20/99).

The most recent dietary risk assessment for pyraclostrobin was conducted by L. Cheng (6/13/2007, DP # 340582).

II.	Residue Information

Pyraclostrobin belongs to the strobilurin class of fungicides.  Strobilurins are synthetic analogs of a natural antifungal substance which inhibits spore germination, mycelial growth, and sporulation of the fungus on the leaf surface.  Pyraclostrobin tolerances have been established in 40 CFR §180.582.  Tolerances for plant commodities are listed in 40 CFR §180.582 (a)(1) in terms of the combined residues of the fungicide pyraclostrobin (carbamic acid, [2-[[[1-(4-chlorophenyl)-1H- pyrazol-3-yl]oxy]methyl]phenyl]methoxy-, methyl ester) and its desmethoxy metabolite, methyl 2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]phenyl carbamate, expressed as parent compound.

HED Metabolism Assessment Review Committee (MARC memo of 10/9/01, DP# 278044, L. Cheng) determined that for purposes of tolerance and dietary risk assessments, the residues of concern in plant and rotational crop commodities include pyraclostrobin and the desmethoxy metabolite.   The residues of concern in livestock commodities include pyraclostrobin and its metabolites convertible to 1-(4-chlorophenyl)-1H-pyrazol-3-ol and 1-(4-chloro-2-hydroxyphenyl)-1H-pyrazol-3-ol.

Residue Data used for Acute, Chronic, and/or Cancer Assessments:

For the acute dietary analysis, tolerance level or highest field trial residues were used for all crops. One hundred percent crop treated was assumed for all commodities in the assessment. For the chronic dietary analysis, anticipated residues were derived for certain crops (apple, broccoli, celery, collard, grape, lettuce, citrus, pepper, mustard green and tomato), which are the major dietary contributors based on preliminary runs. Experimentally derived processing factors for apple juice, grape juice, citrus juices, tomato paste, tomato puree, wheat flour, and wheat germ were applied.  For all other processed commodities, DEEM (ver. 7.81) default processing factors were assumed.  For food residue data used in the chronic and acute dietary assessment are summarized in Table 1 in the appendix.

BASF requests the establishment of tolerances for pyraclostrobin in/on oats grain, oats hay, oats straw and oilseed, crop group 20.  IR-4 requests the establishment of pyraclostrobin tolerances in/on the herb subgroup 19A (fresh herb), avocado, sapote black, canistel, sapote mamey, mango, papaya, sapodilla and star apple.  Also, IR-4 requests the establishment of tolerances for pyraclostrobin in/on barley grain and barley straw.

A summary of the proposed and recommended tolerances for the new uses are listed in Table 1.

Table 1.	Tolerance Summary for Pyraclostrobin

Commodity	Proposed Tolerance (ppm)	Recommended Tolerance (ppm)	Comments; Correct Commodity Definition

Tolerances Proposed Under PP#6E7105

Oats grain	1.0	1.2	Tolerance recommendations are tentative pending submission of a revised Section B to specify PHIs of 20-26 days for oat grain and straw and 6-8 days for oat hay.

Oat, grain; oat, hay, and oat straw.

Oats, hay	17	18

	Oats, straw	17	15

	Oilseed, group 20	0.4	Canola, seed at 0.45

Flax, seed at 0.45	A crop group tolerance will not be appropriate at this time until the Federal Register is issued revising the Crop Group Regulation to establish the Oilseed Crop Group 20.  In the interim, HED is recommending individual tolerances on canola seed and flax seed.

Tolerances Proposed Under PP#6E7165

Herb subgroup 19A, fresh herb	30.0	25	Tolerance recommendation is tentative pending submission of a revised Section B to specify a maximum seasonal rate of 0.8 lb ai/A.  Herbs subgroup 19A

Avocado	0.7	0.6	Tolerance recommendation is tentative pending submissions of residue decline data and a revised Section B to specify a maximum seasonal rate of ~0.8 lb ai/A

Sapote, black	0.7	0.6	Tolerance recommendations are based on residue data translated from avocado.

Canistel	0.7	0.6

	Sapote, mamey	0.7	0.6

	Mango	0.7	0.6

	Papaya	0.7	0.6

	Sapodilla	0.7	0.6

	Star Apple	0.7	0.6

	Additional Tolerances That Need to be Proposed Under PP#6E7165

Basil, dried leaves	--	85

	Dill, seed	--	25

	Tolerances Proposed Under PP#7E7245

Barley, grain	1.3	1.4	Adequate field trial data are available on barley based on regional use.

Barley, straw	9.0	6.0

The potential for secondary transfer of pyraclostrobin residues of concern in meat, milk, poultry, and eggs exists because there are several livestock feedstuffs (canola meal, oat grain, oat forage, oat straw, and oat hay) that are associated with the proposed uses in the current petitions.  The calculated dietary burdens of pyraclostrobin are 11.9 ppm for beef and dairy cattle, and 1.0 ppm for poultry, and 0.2 ppm for swine.  Based on these dietary exposure levels and the residue data from the ruminant feeding study, the existing pyraclostrobin tolerances for milk (0.1 ppm), meat (0.1 ppm), fat (0.1 ppm), meat byproducts except liver (0.2 ppm), and liver (1.5 ppm) of cattle, goats, hogs, horses, and sheep are adequate to support the proposed uses.  Tolerances for eggs and poultry are not needed based on data from the poultry feeding and metabolism studies [Category 180.6(a)(3)].

 Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (G. Rothman, DP Barcodes 336190, 340588, 342584, 9/6/2007) and incorporated directly into this dietary assessment.  Water residues were incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.”

g/L.  In the acute analysis, the 1-in-10 year peak surface water value of 35.6 ppb was used and in the chronic analysis the surface water value of 2.3 ppb was used.  These values are higher than the groundwater value of 0.02 ppb.  The models and their descriptions are available at the EPA internet site:   HYPERLINK "http://www.epa.gov/oppefed1/models/water/"  http://www.epa.gov/oppefed1/models/water/ .

g/L)

	1-in-10 year Annual Peak (Acute)	1-in-10 year Annual Mean (Chronic)	30 year annual mean

(Cancer)

FL Turf	11.6	1.1	0.8

PA Turf	13.5	0.9	0.7

CA Nursery (no irrigation)	32.4	2.1	1.2

FL Nursery (no irrigation)	22.3	2.1	1.4

MI Nursery (no irrigation)	19.4	1.4	1.0

NJ Nursery (no irrigation)	35.6	2.3	1.5

OR Nursery (no irrigation)	6.1	0.9	0.8

TN Nursery (no irrigation)	17.3	2.2	1.5

IV.	DEEM-FCID™ Program and Consumption Information

Pyraclostrobin acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID™, Version 2.03), which incorporates consumption data from USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, for tiers 1 and 2, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

V.	Toxicological Information

The toxicity endpoints pertinent for human risk assessment are summarized in Table 3.

Table 3. Summary of Toxicological Doses and Endpoints for Pyraclostrobin for Use in Dietary Human Health Risk Assessments

Exposure/

Scenario	Point of Departure	Uncertainty/

FQPA Safety Factors	RfD, PAD, Level of Concern for Risk Assessment

Study and Toxicological Effects

Acute Dietary

(Females 13-49 years of age)	NOAEL= 5.0 mg/kg/day	UFA= 10x

UFH= 10x

FQPA SF= 1x

	Acute RfD = 0.05 mg/kg/day

aPAD = 0.05 mg/kg/day	Rabbit Prenatal Developmental Toxicity

LOAEL = 10.0 mg/kg/day based on developmental toxicity findings of increased resorptions.

Acute Dietary (General Population, including Infants and Children)	NOAEL = 300 mg/kg/day	UFA= 10x

UFH= 10x

FQPA SF= 1x 	Acute RfD = 3.0 mg/kg/day

aPAD = 3.0 mg/kg/day	  SEQ CHAPTER \h \r 1 Rat Acute Oral Neurotoxicity

LOAEL = 1000 mg/kg/day based on decreased body weight gain in males.

Chronic Dietary (All Populations)	NOAEL= 3.4 mg/kg/day	UFA= 10x

UFH= 10x

FQPA SF= 1x

	Chronic RfD = 0.034 mg/kg/day

cPAD = 0.034 mg/kg/day	  SEQ CHAPTER \h \r 1 Rat Oral Carcinogenicity

LOAEL = 9.2 mg/kg/day based on decreased body weight/body weight gain, kidney tubular casts and atrophy in both sexes; increased incidence of  liver necrosis and erosion/ulceration of the glandular- stomach and fore-stomach in males.

Cancer (oral) 	Classification:  “Not likely to be Carcinogenic to Humans” based on the absence of significant tumor increases in two adequate rodent carcinogenicity studies.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and  used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures.  NOAEL = no observed adverse effect level.  LOAEL = lowest observed adverse effect level.  UF = uncertainty factor.  UFA = extrapolation from animal to human (intraspecies).  UFH = potential variation in sensitivity among members of the human population (interspecies).  UFL = use of a LOAEL to extrapolate a NOAEL.  UFS = use of a short-term study for long-term risk assessment.  UFDB = to account for the absence of key date (i.e., lack of a critical study).  FQPA SF = FQPA Safety Factor.  PAD = population adjusted dose (a = acute, c = chronic).  RfD = reference dose.  MOE = margin of exposure.

VI.	Results/Discussion

Results of Acute Dietary Exposure Analysis

The results of the aggregate acute dietary analysis for food and water indicate that acute dietary risks do not exceed the Agency’s level of concern (< 100% of the aPAD) for the U.S. population and all subgroups. At the 95th percentile, the U.S. population has an exposure from food and water that results in a risk estimate for the general U.S. population of 1% of the aPAD.  The most highly exposed subpopulation is “females 13-49 years” at 80% of the aPAD. The results of the acute dietary exposure analysis at the 95th, 99th, and 99.9th percentiles of exposure are reported in Table 4 below.

Table 4.  Results of Pyraclostrobin Acute Dietary Exposure Analysis Using  DEEM FCID  - Food and Water

Population Subgroup	aPAD (mg/kg/day)	95th Percentile	99th Percentile 99.9th Percentile

Exposure (mg/kg/day)	% aPAD	Exposure (mg/kg/day)	% aPAD	Exposure (mg/kg/day)	% aPAD

General U.S. Population	3.0	0.043307	1.4	0.075894	2.5	0.151649	5.1

All Infants (< 1 year old)	3.0	0.054851	1.8	0.177712	5.9	0.445852	15

Children 1-2 years old	3.0	0.072457	2.4	0.134193	4.5	0.401209	13

Children 3-5 years old	3.0	0.064339	2.1	0.108640	3.6	0.283085	9.4

Children 6-12 years old	3.0	0.045998	1.5	0.072844	2.4	0.139214	4.6

Youth 13-19 years old	3.0	0.034994	1.2	0.065401	2.2	0.095744	3.2

Adults 20-49 years old	3.0	0.038848	1.3	0.070915	2.4	0.124339	4.1

Adults 50+ years old	3.0	0.041048	1.4	0.072415	2.4	0.128286	4.3

Females 13-49 years old 	0.05	0.040151	80	0.073271	146	0.142240	284

Results of Chronic Dietary Exposure Analysis

The results of the aggregate chronic dietary analysis for food and drinking water are below the Agency’s level of concern (<100% cPAD) for the general U.S. population (18% cPAD) and all population subgroups.  The most highly exposed population subgroup is children 1-2 yrs at 48% of the cPAD.  The results of the acute and chronic dietary exposure analyses are reported in Table 5 below.

Table 5.  Summary of Dietary Exposure and Risk for Pyraclostrobin – Food & Water

Population Subgroup	Acute Dietary

(95th Percentile)	Chronic Dietary	Cancer

	Dietary Exposure (mg/kg/day)	% aPAD	Dietary Exposure

(mg/kg/day)	% cPAD	Dietary Exposure

(mg/kg/day)	Risk

General U.S. Population	0.043307	1.4	0.006149	18	A separate quantitative cancer risk assessment is not required.

All Infants (< 1 year old)	0.054851	1.8	0.010702	32

	Children 1-2 years old	0.072457	2.4	0.016427	48

	Children 3-5 years old	0.064339	2.1	0.012376	36

	Children 6-12 years old	0.045998	1.5	0.007378	22

	Youth 13-19 years old	0.034994	1.2	0.004347	13

	Adults 20-49 years old	0.038848	1.3	0.004983	15

	Adults 50+ years old	0.041048	1.4	0.005731	17

	Females 13-49 years old	0.040151	80	0.004708	14

Cancer Dietary Exposure Results and Characterization

As noted above, the HED CARC has recently revisited the cancer classification for pyraclostrobin.  HED has reclassified pyraclostrobin as “not likely to be carcinogenic to humans" and determined that regulation of cancer risk using an MOE approach is no longer appropriate.

VIII.	Characterization of Inputs/Outputs

The acute and chronic dietary risk assessments are considered only minimally refined.

The acute analysis was conducted using tolerance level residues or the highest residues for all commodities. These tolerance level or highest residues were derived from field trial data conducted at the maximum application rate and minimum PHI permitted on the proposed or existing labels.  For all commodities 100% crop treated was assumed.  A limited number of experimentally derived processing factors were used to refine the acute and chronic analyses. The chronic dietary assessment was conducted using tolerance level residues for all crops except for apple, celery, grape, head lettuce, leaf lettuce, orange, pepper, spinach, tomato and additional crops in the leafy vegetables group where average residue values were derived from crop field trials.  The contribution of residues in drinking water to the dietary risk is minimal.  The chronic critical commodity contribution analysis showed the highest food contributors are milk at 19% of the total exposure for children 1-2 yrs.  HED concludes that the acute exposure estimates are unlikely to underestimate actual acute exposure.

IX.  	Conclusions

The results of the acute dietary analysis for food and water indicate that acute dietary risks do not exceed the Agency’s level of concern (< 100% of the aPAD) for the U.S. population and all subgroups.  Combined dietary from food and drinking water at the 95th percentile of exposure is estimated to be 0.043307 mg/kg/day for the overall U.S. population, equivalent to 1% of the acute Population Adjusted Dose (aPAD).  The population subgroup with the highest estimated acute dietary exposure to pyraclostrobin is females 13-49 years, with an estimated exposure at the 95th percentile of 0.040151 mg/kg/day, equivalent to 80% of the aPAD.

The results of the chronic dietary analysis for food and drinking water are below the Agency’s level of concern (<100% cPAD) for all population subgroups. The dietary exposure is estimated at 0.006149 mg/kg/day for the general U.S. population (18% of the chronic Population Adjusted Dose (cPAD)) and 0.016427 mg/kg/day (48% of the cPAD) for children 1-2 yrs, the population subgroup with the highest estimated chronic dietary exposure to pyraclostrobin.

X.	List of Attachments

Attachment 1.  Data and Residue Estimates Used in Dietary Analysis

Attachment 2.  Pyraclostrobin Acute Dietary Analysis Input File - Food & Water

Attachment 3.  Pyraclostrobin Acute Dietary Analysis Results - Food & Water

Attachment 4.  Pyraclostrobin Chronic Dietary Analysis Input File - Food & Water

Attachment 5.  Pyraclostrobin Chronic Dietary Analysis Results - Food & Water

Attachment 6.  Pyraclostrobin Chronic Critical Commodity Contribution Analysis – Food & Water

Appendix

Attachment 1. Data and Residue Estimates Used in Dietary Analysis

Table 1:  Data and Residue Estimates Used in the Pyraclostrobin Dietary Analyses

RAC	Classification1	Data

Source	No. of

Samples	No. of

Detectable

Residues	%CT	Processing

Factors	Anticipated Residue Estimates/Tolerance (ppm)

	Acute (Tolerance, Tol., or Highest Residues, HR)	Chronic (Tol., or Average Residues, AR)2

Amaranth, leafy	PB	Tolerance & Field Trial Data for spinach 46109101 celery 46109102 head lettuce 45832001	16	16	100	None	HR (23.38)	AR (11.77)

Arugula

AR (11.77)

Chrysanthemum

AR (11.77)

Cress, garden

AR (11.77)

Cress, upland

AR (11.77)

Dandelion, leaves

AR (11.77)

Fennel

AR (5.02)

Parsley, leaves

AR (11.77)

Radicchio

AR (0.59)

Rhubarb

AR (5.02)

Spinach

AR (11.77)

Swiss chard

AR (5.02)

Apple	NB, PB	Tolerance & Field Trial Data 45645803	32	32	100	Juice at 0.2x

MRID 45645804	Tol (1.5)	AR (0.31)

Avocado	NB	Tolerance & Field Trial Data 47014804	14	14	100	None	Tol (0.6)	Tol (0.6)

Barley	B	Tolerance & Field Trial Data 45118535	25	6	100	None	Tol (1.4) Tol (1.4)

Basil	B	Tolerance & Field Trial Data 47014803	8	8	100	None	Tol (25)	Tol (25)

Basil, dried leaves	B	Tolerance & Field Trial Data 47014803	4	4	100	None Tol (85)	Tol (85)

Beans, dry	B	Tolerance & Field Trial Data 45367501	20	4	100	None	HR (0.21)	Tol (0.50)

Berries, CG 13	PB	Tolerance & Field Trial Data 46637701	18	18	100	None Tol (4.0)3	Tol (4.0) 3

Broccoli	NB, PB	Tolerance & Field Trial Data D269668	14	14	100	None	Tol (5.0)	AR (1.10)

Canola/Flax 	B	Tolerance & Field Trial Data 46925301	32	32	100	None	Tol (0.45)	Tol (0.45)

Celery	NB, PB, B	Tolerance & Field Trial Data 46109102	24	24	100	None	HR (10.7)	AR (5.02)

Chives	B	Tolerance & Field Trial Data 47014802	8	8	100	None	Tol (25)	Tol (7.8)

Citrus (except orange)	NB, PB	Tolerance & Field Trial Data	22	22	100 Juice at 0.02x (45118617)	Tol (2.0)	Tol (2.0)

Collards	NB, PB	Tolerance & Field Trial Data mustard greens 46665506	8	8 100	None	Tol (16.0)	AR (5.74)

Cottonseed	B	Tolerance & Field Trial Data 46685901	24	24	100	None	Tol (0.3) 5	Tol (0.3) 5

Cucurbit, CG 9	NB, PB	Tolerance & Field Trial Data 46512002	20	20	100 None	Tol (0.5)	Tol (0.5)

Endive, Belgian	PB	Tolerance & Field Trial Data 46713801	6	6	100	None Tol (11) 6	Tol (11) 6

Dill, seed	B	Tolerance & Field Trial Data 47014801	6	6	100	None	Tol (25) Tol (25)

Grape	PB	Tolerance & Field Trial Data 45118529 45118531	26	26	100	Juice at 0.01x (45118616)	Tol (2.0)	AR (0.768)

Grape, raisin	PB	Tolerance & Field Trial Data 46665504	8	8	100	1.0x (46665504)	Tol (7.0)	Tol (7.0)

Lettuce, head 	NB	Tolerance & Field Trial Data 45832001	5	5	100	None	HR (14.4)	AR (0.59)

Lettuce, leaf	PB	Tolerance & Field Trial Data 45832001	12	12	100	None	HR (20.1)	AR (7.68)

Mango	NB, PB	Tolerance & Field Trial Data 47014804 avocado data	14	14 100	None	Tol (0.6)	Tol (0.6)

Mint	B	Tolerance & Field Trial Data 46665502	4	4	100	Oil at 0.01x

(46665502)	Tol (8)	Tol (8)

Mustard greens	NB, PB	Tolerance & Field Trial Data 46665506	8	8	100	None Tol (16.0)	AR (5.74)

Oats	B	Tolerance & Field Trial Data 46902226	24	24	100	None	Tol (1.2) Tol (1.2)

Orange	NB, PB	Tolerance & Field Trial Data 45903601	26	26	100	Juice at 0.02x (45118617)	Tol (2.0)	AR (0.30)

Papaya	NB, PB	Tolerance & Field Trial Data 47014804 avocado data	14	14 100	None	Tol (0.6)	Tol (0.6)

Pea, dry	B	Tolerance & Field Trial Data 45596211	18	13	100	None	HR (0.10)	Tol (0.50)

Pepper	NB, PB	Tolerance & Field Trial Data 45118611	18	17	100	None	Tol (1.4)	AR (0.232)

Rapeseed	B	Tolerance & Field Trial Data 46925301	32	32	100	None	Tol (0.45)7	Tol (0.45) 7

Sesame seeds	B	Tolerance & Field Trial Data 46925301	32	32	100	None	Tol (0.45)7	Tol (0.45) 7

Sunflower seeds	B	Tolerance & Field Trial Data 46925301	32	32	100	None Tol (0.3)4	Tol (0.3) 4

Tomato	NB, PB	Tolerance & Field Trial Data 45118528	30	30	100	Paste at 2.1x; Puree at 0.55x (45118615)	Tol (1.4)	AR (0.158)

Wheat

(Triticale)	B	Tolerance & Field Trial Data 45118537 	122	30	100	Flour at 0.7x; Germ at 0.85x  (45321101)	Tol (0.20) 8	Tol (0.20) 8

Water	N/A	Modeling	N/A	N/A	N/A	N/A	0.0356	0.0023

N/A =  not applicable.

1.  	Classification of blended (B), partially blended (PB), not blended (NB)

2.	Chronic ARs are based on LOQ (0.04 ppm)

3.  	Berries increase tolerance from 1.3 ppm to 4.0 ppm (L. Cheng, DP340582, 6/13/07)

4.  	Sunflower seeds granted a tolerance of 0.3 ppm (J. Stokes, DP343754, 1/24/08)

5.  	Cottonseed, undelinted granted a tolerance of 0.3 ppm (L. Cheng, DP340582, 6/13/07)

6.  	Belgian endive increase tolerance from 6 ppm to 11 ppm (L. Cheng, DP340582, 6/13/07)

7.	Rapeseed and sesame seed granted a tolerance of 0.45 ppm (J. Stokes, DP343754, 1/24/08)

8.  	Wheat grain tolerance is 0.2 ppm (0.02 ppm in the 40 CFR is a typographical error)

Attachment 2.  Pyraclostrobin Acute Dietary Analysis Input File – Food & Water

U.S. Environmental Protection Agency                                 Ver. 2.02

DEEM-FCID Acute analysis for PYRACLOSTROBIN

Residue file name: C:\DEEMFCID\Pyraclostrobin\Pyraclostrobin_foodH2O.R98

Analysis Date 02-11-2008             Residue file dated: 02-06-2008/14:24:01/8

Reference dose: aRfD = 3 mg/kg bw/day  NOEL = 300 mg/kg bw/day

Comment: Food and drinking water

------------------------------------------------------------------------ --------

  EPA    Crop                                   Def Res     Adj.Factors   Comment

  Code    Grp  Food Name                         (ppm)       #1    #2

-------- ---- -------------------------------  ----------  ------ ------  -------

14000030 14   Almond                             0.040000   1.000  1.000

14000040 14   Almond, oil                        0.040000   1.000  1.000

04010050 4A   Amaranth, leafy                   23.380000   1.000  1.000

11000070 11   Apple, fruit with peel             1.500000   1.000  1.000

11000080 11   Apple, peeled fruit                1.500000   1.000  1.000

11000081 11   Apple, peeled fruit-babyfood       1.500000   1.000  1.000

11000090 11   Apple, dried                       1.500000   8.000  1.000

11000091 11   Apple, dried-babyfood              1.500000   8.000  1.000

11000100 11   Apple, juice                       1.500000   0.200  1.000

11000101 11   Apple, juice-babyfood              1.500000   0.200  1.000

11000110 11   Apple, sauce                       1.500000   1.000  1.000

11000111 11   Apple, sauce-babyfood              1.500000   1.000  1.000

12000120 12   Apricot                            0.900000   1.000  1.000

12000121 12   Apricot-babyfood                   0.900000   1.000  1.000

12000130 12   Apricot, dried                     0.900000   6.000  1.000

12000140 12   Apricot, juice                     0.900000   1.000  1.000

12000141 12   Apricot, juice-babyfood            0.900000   1.000  1.000

01030150 1CD  Arrowroot, flour                   0.040000   1.000  1.000

01030170 1CD  Artichoke, Jerusalem               0.040000   1.000  1.000

04010180 4A   Arugula                           23.380000   1.000  1.000

95000200 O    Avocado                            0.600000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

09020210 9B   Balsam pear                        0.500000   1.000  1.000

95000230 O    Banana                             0.040000   1.000  1.000

95000231 O    Banana-babyfood                    0.040000   1.000  1.000

95000240 O    Banana, dried                      0.040000   3.900  1.000

95000241 O    Banana, dried-babyfood             0.040000   3.900  1.000

15000250 15   Barley, pearled barley             1.400000   1.000  1.000PP#7E7

          Full comment: PP#7E7245

15000251 15   Barley, pearled barley-babyfood    1.400000   1.000  1.000PP#7E7

          Full comment: PP#7E7245

15000260 15   Barley, flour                      1.400000   1.000  1.000PP#7E7

          Full comment: PP#7E7245

15000261 15   Barley, flour-babyfood             1.400000   1.000  1.000PP#7E7

          Full comment: PP#7E7245

15000270 15   Barley, bran                       1.400000   1.000  1.000PP#7E7

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19010280 19A  Basil, fresh leaves               25.000000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

19010281 19A  Basil, fresh leaves-babyfood      25.000000   1.000  1.000PP#6E7

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19010290 19A  Basil, dried leaves               85.000000   1.000  1.000PP#6E7

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19010291 19A  Basil, dried leaves-babyfood      85.000000   1.000  1.000PP#6E7

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06030300 6C   Bean, black, seed                  0.210000   1.000  1.000

06020310 6B   Bean, broad, succulent             0.500000   1.000  1.000

06030320 6C   Bean, broad, seed                  0.210000   1.000  1.000

06020330 6B   Bean, cowpea, succulent            0.500000   1.000  1.000

06030340 6C   Bean, cowpea, seed                 0.210000   1.000  1.000

06030350 6C   Bean,  great northern, seed        0.210000   1.000  1.000

06030360 6C   Bean, kidney, seed                 0.210000   1.000  1.000

06020370 6B   Bean, lima, succulent              0.500000   1.000  1.000

06030380 6C   Bean, lima, seed                   0.210000   1.000  1.000

06030390 6C   Bean, mung, seed                   0.210000   1.000  1.000

06030400 6C   Bean, navy, seed                   0.210000   1.000  1.000

06030410 6C   Bean, pink, seed                   0.210000   1.000  1.000

06030420 6C   Bean, pinto, seed                  0.210000   1.000  1.000

06010430 6A   Bean, snap, succulent              0.500000   1.000  1.000

06010431 6A   Bean, snap, succulent-babyfood     0.500000   1.000  1.000

21000440 M    Beef, meat                         0.100000   1.000  1.000

21000441 M    Beef, meat-babyfood                0.100000   1.000  1.000

21000450 M    Beef, meat, dried                  0.100000   1.920  1.000

21000460 M    Beef, meat byproducts              0.200000   1.000  1.000

21000461 M    Beef, meat byproducts-babyfood     0.200000   1.000  1.000

21000470 M    Beef, fat                          0.100000   1.000  1.000

21000471 M    Beef,fat-babyfood                  0.100000   1.000  1.000

21000480 M    Beef, kidney                       0.200000   1.000  1.000

21000490 M    Beef, liver                        1.500000   1.000  1.000

21000491 M    Beef, liver-babyfood               1.500000   1.000  1.000

01010500 1AB  Beet, garden, roots                0.400000   1.000  1.000

01010501 1AB  Beet, garden, roots-babyfood       0.400000   1.000  1.000

02000510 2    Beet, garden, tops                16.000000   1.000  1.000

01010520 1A   Beet, sugar                        0.200000   0.400  1.000

01010521 1A   Beet, sugar-babyfood               0.200000   0.400  1.000

01010530 1A   Beet, sugar, molasses              0.200000   0.400  1.000

01010531 1A   Beet, sugar, molasses-babyfood     0.200000   0.400  1.000

95000540 O    Belgium endive                    11.000000   1.000  1.000

13010550 13A  Blackberry                         4.000000   1.000  1.000

13010560 13A  Blackberry, juice                  4.000000   1.000  1.000

13010561 13A  Blackberry, juice-babyfood         4.000000   1.000  1.000

13020570 13B  Blueberry                          4.000000   1.000  1.000

13020571 13B  Blueberry-babyfood                 4.000000   1.000  1.000

13010580 13A  Boysenberry                        4.000000   1.000  1.000

14000590 14   Brazil nut                         0.040000   1.000  1.000

05010610 5A   Broccoli                           5.000000   1.000  1.000

05010611 5A   Broccoli-babyfood                  5.000000   1.000  1.000

05010620 5A   Broccoli, Chinese                  5.000000   1.000  1.000

05020630 5B   Broccoli raab                     16.000000   1.000  1.000

05010640 5A   Brussels sprouts                   5.000000   1.000  1.000

01010670 1AB  Burdock                            0.400000   1.000  1.000

14000680 14   Butternut                          0.040000   1.000  1.000

05010690 5A   Cabbage                            5.000000   1.000  1.000

05020700 5B   Cabbage, Chinese, bok choy        16.000000   1.000  1.000

05010710 5A   Cabbage, Chinese, napa             5.000000   1.000  1.000

05010720 5A   Cabbage, Chinese, mustard          5.000000   1.000  1.000

95000740 O    Canistel                           0.600000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

09010750 9A   Cantaloupe                         0.500000   1.000  1.000

04020760 4B   Cardoon                           23.380000   1.000  1.000

01010780 1AB  Carrot                             0.400000   1.000  1.000

01010781 1AB  Carrot-babyfood                    0.400000   1.000  1.000

01010790 1AB  Carrot, juice                      0.400000   1.000  1.000

09010800 9A   Casaba                             0.500000   1.000  1.000

14000810 14   Cashew                             0.040000   1.000  1.000

01030820 1CD  Cassava                            0.040000   1.000  1.000

01030821 1CD  Cassava-babyfood                   0.040000   1.000  1.000

05010830 5A   Cauliflower                        5.000000   1.000  1.000

01010840 1AB  Celeriac                           0.400000   1.000  1.000

04020850 4B   Celery                            10.700000   1.000  1.000

04020851 4B   Celery-babyfood                   10.700000   1.000  1.000

04020860 4B   Celery, juice                     10.700000   1.000  1.000

04020870 4B   Celtuce                           10.700000   1.000  1.000

09020880 9B   Chayote, fruit                     0.500000   1.000  1.000

12000900 12   Cherry                             0.900000   1.000  1.000

12000901 12   Cherry-babyfood                    0.900000   1.000  1.000

12000910 12   Cherry, juice                      0.900000   1.500  1.000

12000911 12   Cherry, juice-babyfood             0.900000   1.500  1.000

14000920 14   Chestnut                           0.040000   1.000  1.000

06030980 6C   Chickpea, seed                     0.340000   1.000  1.000

06030981 6C   Chickpea, seed-babyfood            0.340000   1.000  1.000

06030990 6C   Chickpea, flour                    0.340000   1.000  1.000

01011000 1AB  Chicory, roots                     0.400000   1.000  1.000

02001010 2    Chicory, tops                     16.000000   1.000  1.000

09021020 9B   Chinese waxgourd                   0.500000   1.000  1.000

19011030 19A  Chive                             25.000000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

04011040 4A   Chrysanthemum, garland            23.380000   1.000  1.000

10001060 10   Citrus citron                      2.000000   1.000  1.000

10001070 10   Citrus hybrids                     2.000000   1.000  1.000

10001080 10   Citrus, oil                        9.000000   1.000  1.000

05021170 5B   Collards                          16.000000   1.000  1.000

19011180 19A  Coriander, leaves                 25.000000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

19011181 19A  Coriander, leaves-babyfood        25.000000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

15001200 15   Corn, field, flour                 0.100000   1.000  1.000

15001201 15   Corn, field, flour-babyfood        0.100000   1.000  1.000

15001210 15   Corn, field, meal                  0.100000   1.000  1.000

15001211 15   Corn, field, meal-babyfood         0.100000   1.000  1.000

15001220 15   Corn, field, bran                  0.100000   1.000  1.000

15001230 15   Corn, field, starch                0.100000   1.000  1.000

15001231 15   Corn, field, starch-babyfood       0.100000   1.000  1.000

15001250 15   Corn, field, oil                   0.300000   1.000  1.000

15001251 15   Corn, field, oil-babyfood          0.300000   1.000  1.000

15001260 15   Corn, pop                          0.100000   1.000  1.000

15001270 15   Corn, sweet                        0.040000   1.000  1.000

15001271 15   Corn, sweet-babyfood               0.040000   1.000  1.000

95001280 O    Cottonseed, oil                    0.300000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

95001281 O    Cottonseed, oil-babyfood           0.300000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

11001290 11   Crabapple                          1.500000   1.000  1.000

04011330 4A   Cress, garden                     23.380000   1.000  1.000

04011340 4A   Cress, upland                     23.380000   1.000  1.000

09021350 9B   Cucumber                           0.500000   1.000  1.000

13021360 13B  Currant                            4.000000   1.000  1.000

13021370 13B  Currant, dried                     4.000000   1.000  1.000

04011380 4A   Dandelion, leaves                 23.380000   1.000  1.000

01031390 1CD  Dasheen, corm                      0.040000   1.000  1.000

02001400 2    Dasheen, leaves                   16.000000   1.000  1.000

13011420 13A  Dewberry                           4.000000   1.000  1.000

19021430 19B  Dill, seed                        25.000000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

19011440 19A  Dillweed                          25.000000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

08001480 8    Eggplant                           1.400000   1.000  1.000

13021490 13B  Elderberry                         4.000000   1.000  1.000

04011500 4A   Endive                            23.380000   1.000  1.000

04021520 4B   Fennel, Florence                  23.380000   1.000  1.000

14001550 14   Filbert                            0.040000   1.000  1.000

20001630 20   Flaxseed, oil                      0.450000   1.200  1.000PP#6E7

          Full comment: PP#6E7105

03001640 3    Garlic                             0.900000   1.000  1.000

03001650 3    Garlic, dried                      0.900000   1.000  1.000

03001651 3    Garlic, dried-babyfood             0.900000   1.000  1.000

01031660 1CD  Ginger                             0.040000   1.000  1.000

01031670 1CD  Ginger, dried                      0.040000   1.000  1.000

01011680 1AB  Ginseng, dried                     0.400000   1.000  1.000

23001690 M    Goat, meat                         0.100000   1.000  1.000

23001710 M    Goat, fat                          0.100000   1.000  1.000

13021740 13B  Gooseberry                         4.000000   1.000  1.000

95001750 O    Grape                              2.000000   1.000  1.000

95001760 O    Grape, juice                       2.000000   0.010  1.000

95001761 O    Grape, juice-babyfood              2.000000   0.010  1.000

95001770 O    Grape, leaves                      2.000000   1.000  1.000

95001780 O    Grape, raisin                      7.000000   1.000  1.000

95001790 O    Grape, wine and sherry             2.000000   1.000  1.000

10001800 10   Grapefruit                         2.000000   1.000  1.000

10001810 10   Grapefruit, juice                  2.000000   0.020  1.000

06031820 6C   Guar, seed                         0.340000   1.000  1.000

06031821 6C   Guar, seed-babyfood                0.340000   1.000  1.000

19011840 19A  Herbs, other                      25.000000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

19011841 19A  Herbs, other-babyfood             25.000000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

09011870 9A   Honeydew melon                     0.500000   1.000  1.000

95001880 O    Hop                               23.000000   1.000  1.000

01011900 1AB  Horseradish                        0.400000   1.000  1.000

13021910 13B  Huckleberry                        4.000000   1.000  1.000

05021940 5B   Kale                              16.000000   1.000  1.000

05011960 5A   Kohlrabi                           5.000000   1.000  1.000

10001970 10   Kumquat                            2.000000   1.000  1.000

03001980 3    Leek                               0.900000   1.000  1.000

10001990 10   Lemon                              2.000000   1.000  1.000

10002000 10   Lemon, juice                       2.000000   0.020  1.000

10002001 10   Lemon, juice-babyfood              2.000000   0.020  1.000

10002010 10   Lemon, peel                        2.000000   1.000  1.000

19012020 19A  Lemongrass                        25.000000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

06032030 6C   Lentil, seed                       0.340000   1.000  1.000

04012040 4A   Lettuce, head                     14.400000   1.000  1.000

04012050 4A   Lettuce, leaf                     20.100000   1.000  1.000

10002060 10   Lime                               2.000000   1.000  1.000

10002070 10   Lime, juice                        2.000000   0.020  1.000

10002071 10   Lime, juice-babyfood               2.000000   0.020  1.000

13012080 13A  Loganberry                         4.000000   1.000  1.000

11002100 11   Loquat                             1.500000   1.000  1.000

14002130 14   Macadamia nut                      0.040000   1.000  1.000

95002150 O    Mango                              0.600000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

95002151 O    Mango-babyfood                     0.600000   1.000  1.000PP#6E7

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95002160 O    Mango, dried                       0.600000   1.000  1.000PP#6E7

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95002170 O    Mango, juice                       0.600000   1.000  1.000PP#6E7

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95002171 O    Mango, juice-babyfood              0.600000   1.000  1.000PP#6E7

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19012200 19A  Marjoram                          25.000000   1.000  1.000PP#6E7

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19012201 19A  Marjoram-babyfood                 25.000000   1.000  1.000PP#6E7

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27002220 D    Milk, fat                          0.100000   1.000  1.000

27002221 D    Milk, fat - baby food/infant for   0.100000   1.000  1.000

27012230 D    Milk, nonfat solids                0.100000   1.000  1.000

27012231 D    Milk, nonfat solids-baby food/in   0.100000   1.000  1.000

27022240 D    Milk, water                        0.100000   1.000  1.000

27022241 D    Milk, water-babyfood/infant form   0.100000   1.000  1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.100000   1.000  1.000

05022290 5B   Mustard greens                    16.000000   1.000  1.000

12002300 12   Nectarine                          0.900000   1.000  1.000

15002310 15   Oat, bran                          1.200000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

15002320 15   Oat, flour                         1.200000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

15002321 15   Oat, flour-babyfood                1.200000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

15002330 15   Oat, groats/rolled oats            1.200000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

15002331 15   Oat, groats/rolled oats-babyfood   1.200000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

08002340 8    Okra                               1.400000   1.000  1.000

03002370 3    Onion, dry bulb                    0.900000   1.000  1.000

03002371 3    Onion, dry bulb-babyfood           0.900000   1.000  1.000

03002380 3    Onion, dry bulb, dried             0.900000   9.000  1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.900000   9.000  1.000

03002390 3    Onion, green                       0.900000   1.000  1.000

10002400 10   Orange                             2.000000   1.000  1.000

10002410 10   Orange, juice                      2.000000   0.020  1.000

10002411 10   Orange, juice-babyfood             2.000000   0.020  1.000

10002420 10   Orange, peel                       2.000000   1.000  1.000

95002450 O    Papaya                             0.600000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

95002451 O    Papaya-babyfood                    0.600000   1.000  1.000PP#6E7

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95002460 O    Papaya, dried                      0.600000   1.800  1.000PP#6E7

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95002470 O    Papaya, juice                      0.600000   1.500  1.000PP#6E7

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04012480 4A   Parsley, leaves                   23.380000   1.000  1.000

19012490 19A  Parsley, dried leaves             85.000000   1.000  1.000PP#6E7

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19012491 19A  Parsley, dried leaves-babyfood    85.000000   1.000  1.000PP#6E7

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01012500 1AB  Parsley, turnip rooted             0.400000   1.000  1.000

01012510 1AB  Parsnip                            0.400000   1.000  1.000

01012511 1AB  Parsnip-babyfood                   0.400000   1.000  1.000

06022550 6B   Pea, succulent                     0.200000   1.000  1.000

06022551 6B   Pea, succulent-babyfood            0.200000   1.000  1.000

06032560 6C   Pea, dry                           0.100000   1.000  1.000

06032561 6C   Pea, dry-babyfood                  0.100000   1.000  1.000

06012570 6A   Pea, edible podded, succulent      0.500000   1.000  1.000

06032580 6C   Pea, pigeon, seed                  0.100000   1.000  1.000

06022590 6B   Pea, pigeon, succulent             0.200000   1.000  1.000

12002600 12   Peach                              0.900000   1.000  1.000

12002601 12   Peach-babyfood                     0.900000   1.000  1.000

12002610 12   Peach, dried                       0.900000   7.000  1.000

12002620 12   Peach, juice                       0.900000   1.000  1.000

12002621 12   Peach, juice-babyfood              0.900000   1.000  1.000

95002630 O    Peanut                             0.050000   1.000  1.000

95002640 O    Peanut, butter                     0.050000   1.890  1.000

95002650 O    Peanut, oil                        0.100000   1.900  1.000

11002660 11   Pear                               1.500000   1.000  1.000

11002661 11   Pear-babyfood                      1.500000   1.000  1.000

11002670 11   Pear, dried                        1.500000   6.250  1.000

11002680 11   Pear, juice                        1.500000   1.000  1.000

11002681 11   Pear, juice-babyfood               1.500000   1.000  1.000

14002690 14   Pecan                              0.040000   1.000  1.000

08002700 8    Pepper, bell                       1.400000   1.000  1.000

08002710 8    Pepper, bell, dried                1.400000   1.000  1.000

08002711 8    Pepper, bell, dried-babyfood       1.400000   1.000  1.000

08002720 8    Pepper, nonbell                    1.400000   1.000  1.000

08002721 8    Pepper, nonbell-babyfood           1.400000   1.000  1.000

08002730 8    Pepper, nonbell, dried             1.400000   1.000  1.000

95002750 O    Peppermint                         8.000000   1.000  1.000

95002760 O    Peppermint, oil                    8.000000   1.000  1.000

14002820 14   Pistachio                          0.700000   1.000  1.000

95002830 O    Plantain                           0.040000   1.000  1.000

95002840 O    Plantain, dried                    0.040000   3.900  1.000

12002850 12   Plum                               0.900000   1.000  1.000

12002851 12   Plum-babyfood                      0.900000   1.000  1.000

12002860 12   Plum, prune, fresh                 0.900000   1.000  1.000

12002861 12   Plum, prune, fresh-babyfood        0.900000   1.000  1.000

12002870 12   Plum, prune, dried                 0.900000   1.300  1.000

12002880 12   Plum, prune, juice                 0.900000   1.400  1.000

12002881 12   Plum, prune, juice-babyfood        0.900000   1.400  1.000

25002900 M    Pork, meat                         0.100000   1.000  1.000

25002901 M    Pork, meat-babyfood                0.100000   1.000  1.000

25002910 M    Pork, skin                         0.100000   1.000  1.000

25002920 M    Pork, meat byproducts              0.200000   1.000  1.000

25002921 M    Pork, meat byproducts-babyfood     0.200000   1.000  1.000

25002930 M    Pork, fat                          0.100000   1.000  1.000

25002931 M    Pork, fat-babyfood                 0.100000   1.000  1.000

25002940 M    Pork, kidney                       0.200000   1.000  1.000

25002950 M    Pork, liver                        1.500000   1.000  1.000

01032960 1C   Potato, chips                      0.040000   1.000  1.000

01032970 1C   Potato, dry (granules/ flakes)     0.040000   6.500  1.000

01032971 1C   Potato, dry (granules/ flakes)-b   0.040000   6.500  1.000

01032980 1C   Potato, flour                      0.040000   1.000  1.000

01032981 1C   Potato, flour-babyfood             0.040000   1.000  1.000

01032990 1C   Potato, tuber, w/peel              0.040000   1.000  1.000

01033000 1C   Potato, tuber, w/o peel            0.040000   1.000  1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.040000   1.000  1.000

10003070 10   Pummelo                            2.000000   1.000  1.000

09023080 9B   Pumpkin                            0.500000   1.000  1.000

09023090 9B   Pumpkin, seed                      0.500000   1.000  1.000

11003100 11   Quince                             1.500000   1.000  1.000

04013130 4A   Radicchio                         23.380000   1.000  1.000

01013140 1AB  Radish, roots                      0.400000   1.000  1.000

01013160 1AB  Radish, Oriental, roots            0.400000   1.000  1.000

05023180 5B   Rape greens                       16.000000   1.000  1.000

20003190 20   Rapeseed, oil                      0.450000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

20003191 20   Rapeseed, oil-babyfood             0.450000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

13013200 13A  Raspberry                          4.000000   1.000  1.000

13013201 13A  Raspberry-babyfood                 4.000000   1.000  1.000

13013210 13A  Raspberry, juice                   4.000000   1.000  1.000

13013211 13A  Raspberry, juice-babyfood          4.000000   1.000  1.000

04023220 4B   Rhubarb                           23.380000   1.000  1.000

01013270 1AB  Rutabaga                           0.400000   1.000  1.000

15003280 15   Rye, grain                         0.040000   1.000  1.000

20003300 20   Safflower, oil                     0.450000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

20003301 20   Safflower, oil-babyfood            0.450000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

01013310 1AB  Salsify, roots                     0.400000   1.000  1.000

95003330 O    Sapote, Mamey                      0.600000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

19013340 19A  Savory                            25.000000   1.000  1.000PP#6E7

          Full comment: PP#6E7165

95003360 O    Sesame, seed                       0.450000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

95003361 O    Sesame, seed-babyfood              0.450000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

95003370 O    Sesame, oil                        0.450000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

95003371 O    Sesame, oil-babyfood               0.450000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

03003380 3    Shallot                            0.900000   1.000  1.000

26003390 M    Sheep, meat                        0.100000   1.000  1.000

26003391 M    Sheep, meat-babyfood               0.100000   1.000  1.000

26003400 M    Sheep, meat byproducts             0.200000   1.000  1.000

26003410 M    Sheep, fat                         0.100000   1.000  1.000

26003411 M    Sheep, fat-babyfood                0.100000   1.000  1.000

26003420 M    Sheep, kidney                      0.200000   1.000  1.000

26003430 M    Sheep, liver                       1.500000   1.000  1.000

06003470 6    Soybean, seed                      0.040000   1.000  1.000

06003480 6    Soybean, flour                     0.040000   1.000  1.000

06003481 6    Soybean, flour-babyfood            0.040000   1.000  1.000

06003490 6    Soybean, soy milk                  0.040000   1.000  1.000

06003491 6    Soybean, soy milk-babyfood or in   0.040000   1.000  1.000

06003500 6    Soybean, oil                       0.040000   0.800  1.000

06003501 6    Soybean, oil-babyfood              0.040000   0.800  1.000

95003520 O    Spearmint                          8.000000   1.000  1.000

95003530 O    Spearmint, oil                     8.000000   1.000  1.000

04013550 4A   Spinach                           23.380000   1.000  1.000

04013551 4A   Spinach-babyfood                  23.380000   1.000  1.000

09023560 9B   Squash, summer                     0.500000   1.000  1.000

09023561 9B   Squash, summer-babyfood            0.500000   1.000  1.000

09023570 9B   Squash, winter                     0.500000   1.000  1.000

09023571 9B   Squash, winter-babyfood            0.500000   1.000  1.000

95003590 O    Strawberry                         1.200000   1.000  1.000

95003591 O    Strawberry-babyfood                1.200000   1.000  1.000

95003600 O    Strawberry, juice                  1.200000   1.000  1.000

95003601 O    Strawberry, juice-babyfood         1.200000   1.000  1.000

20003640 20   Sunflower, seed                    0.300000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

20003650 20   Sunflower, oil                     0.300000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

20003651 20   Sunflower, oil-babyfood            0.300000   1.000  1.000PP#6E7

          Full comment: PP#6E7105

01033660 1CD  Sweet potato                       0.040000   1.000  1.000

01033661 1CD  Sweet potato-babyfood              0.040000   1.000  1.000

04023670 4B   Swiss chard                       23.380000   1.000  1.000

10003690 10   Tangerine                          2.000000   1.000  1.000

10003700 10   Tangerine, juice                   2.000000   0.020  1.000

01033710 1CD  Tanier, corm                       0.040000   1.000  1.000

08003740 8    Tomatillo                          1.400000   1.000  1.000

08003750 8    Tomato                             1.400000   1.000  1.000

08003751 8    Tomato-babyfood                    1.400000   1.000  1.000

08003760 8    Tomato, paste                      1.400000   2.100  1.000

08003761 8    Tomato, paste-babyfood             1.400000   2.100  1.000

08003770 8    Tomato, puree                      1.400000   0.550  1.000

08003771 8    Tomato, puree-babyfood             1.400000   0.550  1.000

08003780 8    Tomato, dried                      1.400000  14.300  1.000

08003781 8    Tomato, dried-babyfood             1.400000  14.300  1.000

08003790 8    Tomato, juice                      1.400000   1.500  1.000

15003810 15   Triticale, flour                   0.200000   0.700  1.000

01033870 1CD  Turmeric                           0.040000   1.000  1.000

01013880 1AB  Turnip, roots                      0.400000   1.000  1.000

05023890 5B   Turnip, greens                    16.000000   1.000  1.000

14003910 14   Walnut                             0.040000   1.000  1.000

86010000 O    Water, direct, all sources         0.035600   1.000  1.000

86020000 O    Water, indirect, all sources       0.035600   1.000  1.000

09013990 9A   Watermelon                         0.500000   1.000  1.000

09014000 9A   Watermelon, juice                  0.500000   1.000  1.000

15004010 15   Wheat, grain                       0.200000   1.000  1.000

15004011 15   Wheat, grain-babyfood              0.200000   1.000  1.000

15004020 15   Wheat, flour                       0.200000   0.700  1.000

15004021 15   Wheat, flour-babyfood              0.200000   0.700  1.000

15004030 15   Wheat, germ                        0.200000   0.850  1.000

15004040 15   Wheat, bran                        0.200000   1.000  1.000

01034060 1CD  Yam, true                          0.040000   1.000  1.000

01034070 1CD  Yam bean                           0.040000   1.000  1.000

Attachment 3.  Pyraclostrobin Acute Dietary Analysis Results – Food & Water

U.S. Environmental Protection Agency                                  Ver. 2.02

DEEM-FCID ACUTE Analysis for PYRACLOSTROBIN                      (1994-98 data)

Residue file: Pyraclostrobin_foodH2O.R98              Adjustment factor #2 used.

Analysis Date: 02-11-2008/11:30:41    Residue file dated: 02-06-2008/14:24:01/8

NOEL (Acute) = 300.000000 mg/kg body-wt/day

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Daily totals for food and foodform consumption used.

Run Comment: "Food and drinking water"

======================================================================== =======

Summary calculations (per capita):

      95th Percentile             99th Percentile             99.9th Percentile

 Exposure  % aPAD     MOE    Exposure  % aPAD     MOE    Exposure  % aPAD     MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

U.S. Population:

  0.043307    1.44    6927    0.075894    2.53    3952    0.151649    5.05    1978

All infants:

  0.054851    1.83    5469    0.177712    5.92    1688    0.445852   14.86     672

Children 1-2 yrs:

  0.072457    2.42    4140    0.134193    4.47    2235    0.401209   13.37     747

Children 3-5 yrs:

  0.064339    2.14    4662    0.108640    3.62    2761    0.283085    9.44    1059

Children 6-12 yrs:

  0.045998    1.53    6522    0.072844    2.43    4118    0.139214    4.64    2154

Youth 13-19 yrs:

  0.034994    1.17    8572    0.065401    2.18    4587    0.095744    3.19    3133

Adults 20-49 yrs:

  0.038848    1.29    7722    0.070915    2.36    4230    0.124339    4.14    2412

Adults 50+ yrs:

  0.041048    1.37    7308    0.072415    2.41    4142    0.128286    4.28    2338

Females 13-49 yrs:

  0.040151   80.30    7471    0.073271  146.54    4094    0.142240  284.48    2109

Attachment 4.  Pyraclostrobin Chronic Dietary Analysis Input File – Food & Water

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for PYRACLOSTROBIN                     1994-98 data

Residue file: C:\DEEMFCID\Pyraclostrobin\PyraclostrobinTol+aveH2O.R98

                                                               Adjust. #2 used

Analysis Date 02-11-2008             Residue file dated: 02-06-2008/14:23:05/8

Reference dose (RfD) = 0.034 mg/kg bw/day

Comment:Food and drinking water

------------------------------------------------------------------------ --------

Food Crop                                       Residue       Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)

                                                             #1         #2

-------- ---- -------------------------------   ---------- ------     ------   -------

14000030 14   Almond                             0.040000   1.000      1.000

14000040 14   Almond, oil                        0.040000   1.000      1.000

04010050 4A   Amaranth, leafy                   11.770000   1.000      1.000

11000070 11   Apple, fruit with peel             0.310000   1.000      1.000

11000080 11   Apple, peeled fruit                0.310000   1.000      1.000

11000081 11   Apple, peeled fruit-babyfood       0.310000   1.000      1.000

11000090 11   Apple, dried                       0.310000   8.000      1.000

11000091 11   Apple, dried-babyfood              0.310000   8.000      1.000

11000100 11   Apple, juice                       0.310000   0.200      1.000

11000101 11   Apple, juice-babyfood              0.310000   0.200      1.000

11000110 11   Apple, sauce                       0.310000   1.000      1.000

11000111 11   Apple, sauce-babyfood              0.310000   1.000      1.000

12000120 12   Apricot                            0.900000   1.000      1.000

12000121 12   Apricot-babyfood                   0.900000   1.000      1.000

12000130 12   Apricot, dried                     0.900000   6.000      1.000

12000140 12   Apricot, juice                     0.900000   1.000      1.000

12000141 12   Apricot, juice-babyfood            0.900000   1.000      1.000

01030150 1CD  Arrowroot, flour                   0.040000   1.000      1.000

01030170 1CD  Artichoke, Jerusalem               0.040000   1.000      1.000

04010180 4A   Arugula                           11.770000   1.000      1.000

95000200 O    Avocado                            0.600000   1.000      1.000   PP#6E7

  Full comment: PP#6E7165

09020210 9B   Balsam pear                        0.500000   1.000      1.000

95000230 O    Banana                             0.040000   1.000      1.000

95000231 O    Banana-babyfood                    0.040000   1.000      1.000

95000240 O    Banana, dried                      0.040000   3.900      1.000

95000241 O    Banana, dried-babyfood             0.040000   3.900      1.000

15000250 15   Barley, pearled barley             1.400000   1.000      1.000   PP#7E7

  Full comment: PP#7E7245

15000251 15   Barley, pearled barley-babyfood    1.400000   1.000      1.000   PP#7E7

  Full comment: PP#7E7245

15000260 15   Barley, flour                      1.400000   1.000      1.000   PP#7E7

  Full comment: PP#7E7245

15000261 15   Barley, flour-babyfood             1.400000   1.000      1.000   PP#7E7

  Full comment: PP#7E7245

15000270 15   Barley, bran                       1.400000   1.000      1.000   PP#7E7

  Full comment: PP#7E7245

19010280 19A  Basil, fresh leaves               25.000000   1.000      1.000   PP#6E7

  Full comment: PP#6E7165

19010281 19A  Basil, fresh leaves-babyfood      25.000000   1.000      1.000   PP#6E7

  Full comment: PP#6E7165

19010290 19A  Basil, dried leaves               85.000000   1.000      1.000   PP#6E7

  Full comment: PP#6E7165

19010291 19A  Basil, dried leaves-babyfood      85.000000   1.000      1.000   PP#6E7

  Full comment: PP#6E7165

06030300 6C   Bean, black, seed                  0.500000   1.000      1.000

06020310 6B   Bean, broad, succulent             0.500000   1.000      1.000

06030320 6C   Bean, broad, seed                  0.500000   1.000      1.000

06020330 6B   Bean, cowpea, succulent            0.500000   1.000      1.000

06030340 6C   Bean, cowpea, seed                 0.500000   1.000      1.000

06030350 6C   Bean,  great northern, seed        0.500000   1.000      1.000

06030360 6C   Bean, kidney, seed                 0.500000   1.000      1.000

06020370 6B   Bean, lima, succulent              0.500000   1.000      1.000

06030380 6C   Bean, lima, seed                   0.500000   1.000      1.000

06030390 6C   Bean, mung, seed                   0.500000   1.000      1.000

06030400 6C   Bean, navy, seed                   0.500000   1.000      1.000

06030410 6C   Bean, pink, seed                   0.500000   1.000      1.000

06030420 6C   Bean, pinto, seed                  0.500000   1.000      1.000

06010430 6A   Bean, snap, succulent              0.500000   1.000      1.000

06010431 6A   Bean, snap, succulent-babyfood     0.500000   1.000      1.000

21000440 M    Beef, meat                         0.100000   1.000      1.000

21000441 M    Beef, meat-babyfood                0.100000   1.000      1.000

21000450 M    Beef, meat, dried                  0.100000   1.920      1.000

21000460 M    Beef, meat byproducts              0.200000   1.000      1.000

21000461 M    Beef, meat byproducts-babyfood     0.200000   1.000      1.000

21000470 M    Beef, fat                          0.100000   1.000      1.000

21000471 M    Beef,fat-babyfood                  0.100000   1.000      1.000

21000480 M    Beef, kidney                       0.200000   1.000      1.000

21000490 M    Beef, liver                        1.500000   1.000      1.000

21000491 M    Beef, liver-babyfood               1.500000   1.000      1.000

01010500 1AB  Beet, garden, roots                0.400000   1.000      1.000

01010501 1AB  Beet, garden, roots-babyfood       0.400000   1.000      1.000

02000510 2    Beet, garden, tops                16.000000   1.000      1.000

01010520 1A   Beet, sugar                        0.200000   1.000      1.000

01010521 1A   Beet, sugar-babyfood               0.200000   1.000      1.000

01010530 1A   Beet, sugar, molasses              0.200000   1.000      1.000

01010531 1A   Beet, sugar, molasses-babyfood     0.200000   1.000      1.000

95000540 O    Belgium endive                    11.000000   1.000      1.000

13010550 13A  Blackberry                         4.000000   1.000      1.000

13010560 13A  Blackberry, juice                  4.000000   1.000      1.000

13010561 13A  Blackberry, juice-babyfood         4.000000   1.000      1.000

13020570 13B  Blueberry                          4.000000   1.000      1.000

13020571 13B  Blueberry-babyfood                 4.000000   1.000      1.000

13010580 13A  Boysenberry                        4.000000   1.000      1.000

14000590 14   Brazil nut                         0.040000   1.000      1.000

05010610 5A   Broccoli                           1.100000   1.000      1.000

05010611 5A   Broccoli-babyfood                  1.100000   1.000      1.000

05010620 5A   Broccoli, Chinese                  1.100000   1.000      1.000

05020630 5B   Broccoli raab                      5.740000   1.000      1.000

05010640 5A   Brussels sprouts                   5.000000   1.000      1.000

01010670 1AB  Burdock                            0.400000   1.000      1.000

14000680 14   Butternut                          0.040000   1.000      1.000

05010690 5A   Cabbage                            5.000000   1.000      1.000

05020700 5B   Cabbage, Chinese, bok choy         5.740000   1.000      1.000

05010710 5A   Cabbage, Chinese, napa             5.000000   1.000      1.000

05010720 5A   Cabbage, Chinese, mustard          5.000000   1.000      1.000

95000740 O    Canistel                           0.600000   1.000      1.000   PP#6E7

  Full comment: PP#6E7165

09010750 9A   Cantaloupe                         0.500000   1.000      1.000

04020760 4B   Cardoon                           11.770000   1.000      1.000

01010780 1AB  Carrot                             0.400000   1.000      1.000

01010781 1AB  Carrot-babyfood                    0.400000   1.000      1.000

01010790 1AB  Carrot, juice                      0.400000   1.000      1.000

09010800 9A   Casaba                             0.500000   1.000      1.000

14000810 14   Cashew                             0.040000   1.000      1.000

01030820 1CD  Cassava                            0.040000   1.000      1.000

01030821 1CD  Cassava-babyfood                   0.040000   1.000      1.000

05010830 5A   Cauliflower                        5.000000   1.000      1.000

01010840 1AB  Celeriac                           0.400000   1.000      1.000

04020850 4B   Celery                             5.020000   1.000      1.000

04020851 4B   Celery-babyfood                    5.020000   1.000      1.000

04020860 4B   Celery, juice                      5.020000   1.000      1.000

04020870 4B   Celtuce                            5.020000   1.000      1.000

09020880 9B   Chayote, fruit                     0.500000   1.000      1.000

12000900 12   Cherry                             0.900000   1.000      1.000

12000901 12   Cherry-babyfood                    0.900000   1.000      1.000

12000910 12   Cherry, juice                      0.900000   1.500      1.000

12000911 12   Cherry, juice-babyfood             0.900000   1.500      1.000

14000920 14   Chestnut                           0.040000   1.000      1.000

06030980 6C   Chickpea, seed                     0.340000   1.000      1.000

06030981 6C   Chickpea, seed-babyfood            0.340000   1.000      1.000

06030990 6C   Chickpea, flour                    0.340000   1.000      1.000

01011000 1AB  Chicory, roots                     0.400000   1.000      1.000

02001010 2    Chicory, tops                     16.000000   1.000      1.000

09021020 9B   Chinese waxgourd                   0.500000   1.000      1.000

19011030 19A  Chive                             25.000000   1.000      1.000   PP#6E7

  Full comment: PP#6E7165

04011040 4A   Chrysanthemum, garland            11.770000   1.000      1.000

10001060 10   Citrus citron                      2.000000   1.000      1.000

10001070 10   Citrus hybrids                     2.000000   1.000      1.000

10001080 10   Citrus, oil                        9.000000   1.000      1.000

05021170 5B   Collards                           5.740000   1.000      1.000

19011180 19A  Coriander, leaves                 25.000000   1.000      1.000   PP#6E7

  Full comment: PP#6E7165

19011181 19A  Coriander, leaves-babyfood        25.000000   1.000      1.000   PP#6E7

  Full comment: PP#6E7165

15001200 15   Corn, field, flour                 0.100000   1.000      1.000

15001201 15   Corn, field, flour-babyfood        0.100000   1.000      1.000

15001210 15   Corn, field, meal                  0.100000   1.000      1.000

15001211 15   Corn, field, meal-babyfood         0.100000   1.000      1.000

15001220 15   Corn, field, bran                  0.100000   1.000      1.000

15001230 15   Corn, field, starch                0.100000   1.000      1.000

15001231 15   Corn, field, starch-babyfood       0.100000   1.000      1.000

15001250 15   Corn, field, oil                   0.300000   1.000      1.000

15001251 15   Corn, field, oil-babyfood          0.300000   1.000      1.000

15001260 15   Corn, pop                          0.100000   1.000      1.000

15001270 15   Corn, sweet                        0.040000   1.000      1.000

15001271 15   Corn, sweet-babyfood               0.040000   1.000      1.000

95001280 O    Cottonseed, oil                    0.300000   0.300      1.000

95001281 O    Cottonseed, oil-babyfood           0.300000   0.300      1.000

11001290 11   Crabapple                          1.500000   1.000      1.000

04011330 4A   Cress, garden                     11.770000   1.000      1.000

04011340 4A   Cress, upland                     11.770000   1.000      1.000

09021350 9B   Cucumber                           0.500000   1.000      1.000

13021360 13B  Currant                            4.000000   1.000      1.000

13021370 13B  Currant, dried                     4.000000   1.000      1.000

04011380 4A   Dandelion, leaves                 11.770000   1.000      1.000

01031390 1CD  Dasheen, corm                      0.040000   1.000      1.000

02001400 2    Dasheen, leaves                   16.000000   1.000      1.000

13011420 13A  Dewberry                           4.000000   1.000      1.000

19021430 19B  Dill, seed                        25.000000   1.000      1.000   PP#6E7

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19011440 19A  Dillweed                          25.000000   1.000      1.000   PP#6E7

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08001480 8    Eggplant                           1.400000   1.000      1.000

13021490 13B  Elderberry                         4.000000   1.000      1.000

04011500 4A   Endive                            11.770000   1.000      1.000

04021520 4B   Fennel, Florence                   5.020000   1.000      1.000

14001550 14   Filbert                            0.040000   1.000      1.000

20001630 20   Flaxseed, oil                      0.450000   1.200      1.000   PP#6E7

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03001640 3    Garlic                             0.900000   1.000      1.000

03001650 3    Garlic, dried                      0.900000   1.000      1.000

03001651 3    Garlic, dried-babyfood             0.900000   1.000      1.000

01031660 1CD  Ginger                             0.040000   1.000      1.000

01031670 1CD  Ginger, dried                      0.040000   1.000      1.000

01011680 1AB  Ginseng, dried                     0.400000   1.000      1.000

23001690 M    Goat, meat                         0.100000   1.000      1.000

23001710 M    Goat, fat                          0.100000   1.000      1.000

13021740 13B  Gooseberry                         4.000000   1.000      1.000

95001750 O    Grape                              0.768000   1.000      1.000

95001760 O    Grape, juice                       0.768000   0.010      1.000

95001761 O    Grape, juice-babyfood              0.768000   0.010      1.000

95001770 O    Grape, leaves                      0.768000   1.000      1.000

95001780 O    Grape, raisin                      7.000000   1.000      1.000

95001790 O    Grape, wine and sherry             0.768000   1.000      1.000

10001800 10   Grapefruit                         2.000000   1.000      1.000

10001810 10   Grapefruit, juice                  2.000000   1.000      1.000

06031820 6C   Guar, seed                         0.500000   1.000      1.000

06031821 6C   Guar, seed-babyfood                0.500000   1.000      1.000

19011840 19A  Herbs, other                      25.000000   1.000      1.000   PP#6E7

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19011841 19A  Herbs, other-babyfood             25.000000   1.000      1.000   PP#6E7

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09011870 9A   Honeydew melon                     0.500000   1.000      1.000

95001880 O    Hop                               23.000000   1.000      1.000

01011900 1AB  Horseradish                        0.400000   1.000      1.000

13021910 13B  Huckleberry                        4.000000   1.000      1.000

05021940 5B   Kale                               5.740000   1.000      1.000

05011960 5A   Kohlrabi                           5.000000   1.000      1.000

10001970 10   Kumquat                            2.000000   1.000      1.000

03001980 3    Leek                               0.900000   1.000      1.000

10001990 10   Lemon                              2.000000   1.000      1.000

10002000 10   Lemon, juice                       2.000000   0.020      1.000

10002001 10   Lemon, juice-babyfood              2.000000   0.020      1.000

10002010 10   Lemon, peel                        2.000000   1.000      1.000

19012020 19A  Lemongrass                        25.000000   1.000      1.000   PP#6E7

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06032030 6C   Lentil, seed                       0.500000   1.000      1.000

04012040 4A   Lettuce, head                      0.590000   1.000      1.000

04012050 4A   Lettuce, leaf                      7.680000   1.000      1.000

10002060 10   Lime                               2.000000   1.000      1.000

10002070 10   Lime, juice                        2.000000   0.020      1.000

10002071 10   Lime, juice-babyfood               2.000000   0.020      1.000

13012080 13A  Loganberry                         4.000000   1.000      1.000

11002100 11   Loquat                             1.500000   1.000      1.000

14002130 14   Macadamia nut                      0.040000   1.000      1.000

95002140 O    Mamey apple                        0.600000   1.000      1.000   PP#6E7

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95002150 O    Mango                              0.600000   1.000      1.000   PP#6E7

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95002151 O    Mango-babyfood                     0.600000   1.000      1.000   PP#6E7

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95002160 O    Mango, dried                       0.600000   1.000      1.000   PP#6E7

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95002170 O    Mango, juice                       0.600000   1.000      1.000   PP#6E7

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95002171 O    Mango, juice-babyfood              0.600000   1.000      1.000   PP#6E7

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19012200 19A  Marjoram                          25.000000   1.000      1.000   PP#6E7

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19012201 19A  Marjoram-babyfood                 25.000000   1.000      1.000   PP#6E7

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27002220 D    Milk, fat                          0.100000   1.000      1.000

27002221 D    Milk, fat - baby food/infant for   0.100000   1.000      1.000

27012230 D    Milk, nonfat solids                0.100000   1.000      1.000

27012231 D    Milk, nonfat solids-baby food/in   0.100000   1.000      1.000

27022240 D    Milk, water                        0.100000   1.000      1.000

27022241 D    Milk, water-babyfood/infant form   0.100000   1.000      1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.100000   1.000      1.000

05022290 5B   Mustard greens                     5.740000   1.000      1.000

12002300 12   Nectarine                          0.900000   1.000      1.000

15002310 15   Oat, bran                          1.200000   1.000      1.000   PP#6E7

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15002320 15   Oat, flour                         1.200000   1.000      1.000   PP#6E7

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15002321 15   Oat, flour-babyfood                1.200000   1.000      1.000   PP#6E7

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15002330 15   Oat, groats/rolled oats            1.200000   1.000      1.000   PP#6E7

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15002331 15   Oat, groats/rolled oats-babyfood   1.200000   1.000      1.000   PP#6E7

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08002340 8    Okra                               1.400000   1.000      1.000

03002370 3    Onion, dry bulb                    0.900000   1.000      1.000

03002371 3    Onion, dry bulb-babyfood           0.900000   1.000      1.000

03002380 3    Onion, dry bulb, dried             0.900000   9.000      1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.900000   9.000      1.000

03002390 3    Onion, green                       0.900000   1.000      1.000

10002400 10   Orange                             0.300000   1.000      1.000

10002410 10   Orange, juice                      0.300000   0.020      1.000

10002411 10   Orange, juice-babyfood             0.300000   0.020      1.000

10002420 10   Orange, peel                       0.300000   1.000      1.000

95002450 O    Papaya                             0.600000   1.000      1.000   PP#6E7

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95002451 O    Papaya-babyfood                    0.600000   1.000      1.000   PP#6E7

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95002460 O    Papaya, dried                      0.600000   1.800      1.000   PP#6E7

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95002470 O    Papaya, juice                      0.600000   1.500      1.000   PP#6E7

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04012480 4A   Parsley, leaves                   11.770000   1.000      1.000

19012490 19A  Parsley, dried leaves             85.000000   1.000      1.000   PP#6E7

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19012491 19A  Parsley, dried leaves-babyfood    85.000000   1.000      1.000   PP#6E7

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01012500 1AB  Parsley, turnip rooted             0.400000   1.000      1.000

01012510 1AB  Parsnip                            0.400000   1.000      1.000

01012511 1AB  Parsnip-babyfood                   0.400000   1.000      1.000

06022550 6B   Pea, succulent                     0.200000   1.000      1.000

06022551 6B   Pea, succulent-babyfood            0.200000   1.000      1.000

06032560 6C   Pea, dry                           0.500000   1.000      1.000

06032561 6C   Pea, dry-babyfood                  0.500000   1.000      1.000

06012570 6A   Pea, edible podded, succulent      0.500000   1.000      1.000

06032580 6C   Pea, pigeon, seed                  0.500000   1.000      1.000

06022590 6B   Pea, pigeon, succulent             0.200000   1.000      1.000

12002600 12   Peach                              0.900000   1.000      1.000

12002601 12   Peach-babyfood                     0.900000   1.000      1.000

12002610 12   Peach, dried                       0.900000   7.000      1.000

12002620 12   Peach, juice                       0.900000   1.000      1.000

12002621 12   Peach, juice-babyfood              0.900000   1.000      1.000

95002630 O    Peanut                             0.050000   1.000      1.000

95002640 O    Peanut, butter                     0.050000   1.890      1.000

95002650 O    Peanut, oil                        0.100000   1.900      1.000

11002660 11   Pear                               1.500000   1.000      1.000

11002661 11   Pear-babyfood                      1.500000   1.000      1.000

11002670 11   Pear, dried                        1.500000   6.250      1.000

11002680 11   Pear, juice                        1.500000   1.000      1.000

11002681 11   Pear, juice-babyfood               1.500000   1.000      1.000

14002690 14   Pecan                              0.040000   1.000      1.000

08002700 8    Pepper, bell                       0.232000   1.000      1.000

08002701 8    Pepper, bell-babyfood              0.232000   1.000      1.000

08002710 8    Pepper, bell, dried                0.232000   1.000      1.000

08002711 8    Pepper, bell, dried-babyfood       0.232000   1.000      1.000

08002720 8    Pepper, nonbell                    0.232000   1.000      1.000

08002721 8    Pepper, nonbell-babyfood           0.232000   1.000      1.000

08002730 8    Pepper, nonbell, dried             0.232000   1.000      1.000

95002750 O    Peppermint                         8.000000   1.000      1.000

95002760 O    Peppermint, oil                    8.000000   1.000      1.000

14002820 14   Pistachio                          0.700000   1.000      1.000

95002830 O    Plantain                           0.040000   1.000      1.000

95002840 O    Plantain, dried                    0.040000   3.900      1.000

12002850 12   Plum                               0.900000   1.000      1.000

12002851 12   Plum-babyfood                      0.900000   1.000      1.000

12002860 12   Plum, prune, fresh                 0.900000   1.000      1.000

12002861 12   Plum, prune, fresh-babyfood        0.900000   1.000      1.000

12002870 12   Plum, prune, dried                 0.900000   1.300      1.000

12002880 12   Plum, prune, juice                 0.900000   1.400      1.000

12002881 12   Plum, prune, juice-babyfood        0.900000   1.400      1.000

25002900 M    Pork, meat                         0.100000   1.000      1.000

25002901 M    Pork, meat-babyfood                0.100000   1.000      1.000

25002910 M    Pork, skin                         0.100000   1.000      1.000

25002920 M    Pork, meat byproducts              0.200000   1.000      1.000

25002921 M    Pork, meat byproducts-babyfood     0.200000   1.000      1.000

25002930 M    Pork, fat                          0.100000   1.000      1.000

25002931 M    Pork, fat-babyfood                 0.100000   1.000      1.000

25002940 M    Pork, kidney                       0.200000   1.000      1.000

25002950 M    Pork, liver                        1.500000   1.000      1.000

01032960 1C   Potato, chips                      0.040000   1.000      1.000

01032970 1C   Potato, dry (granules/ flakes)     0.040000   6.500      1.000

01032971 1C   Potato, dry (granules/ flakes)-b   0.040000   6.500      1.000

01032980 1C   Potato, flour                      0.040000   1.000      1.000

01032981 1C   Potato, flour-babyfood             0.040000   1.000      1.000

01032990 1C   Potato, tuber, w/peel              0.040000   1.000      1.000

01033000 1C   Potato, tuber, w/o peel            0.040000   1.000      1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.040000   1.000      1.000

10003070 10   Pummelo                            2.000000   1.000      1.000

09023080 9B   Pumpkin                            0.500000   1.000      1.000

09023090 9B   Pumpkin, seed                      0.500000   1.000      1.000

11003100 11   Quince                             1.500000   1.000      1.000

04013130 4A   Radicchio                          0.590000   1.000      1.000

01013140 1AB  Radish, roots                      0.400000   1.000      1.000

01013160 1AB  Radish, Oriental, roots            0.400000   1.000      1.000

05023180 5B   Rape greens                        5.740000   1.000      1.000

20003190 20   Rapeseed, oil                      0.450000   1.000      1.000   PP#6E7

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20003191 20   Rapeseed, oil-babyfood             0.450000   1.000      1.000   PP#6E7

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13013200 13A  Raspberry                          4.000000   1.000      1.000

13013201 13A  Raspberry-babyfood                 4.000000   1.000      1.000

13013210 13A  Raspberry, juice                   4.000000   1.000      1.000

13013211 13A  Raspberry, juice-babyfood          4.000000   1.000      1.000

04023220 4B   Rhubarb                            5.020000   1.000      1.000

01013270 1AB  Rutabaga                           0.400000   1.000      1.000

15003280 15   Rye, grain                         0.040000   1.000      1.000

20003300 20   Safflower, oil                     0.450000   1.000      1.000   PP#6E7

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20003301 20   Safflower, oil-babyfood            0.450000   1.000      1.000   PP#6E7

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01013310 1AB  Salsify, roots                     0.400000   1.000      1.000

95003330 O    Sapote, Mamey                      0.600000   1.000      1.000   PP#6E7

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19013340 19A  Savory                            25.000000   1.000      1.000   PP#6E7

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95003360 O    Sesame, seed                       0.450000   1.000      1.000   PP#6E7

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95003361 O    Sesame, seed-babyfood              0.450000   1.000      1.000   PP#6E7

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95003370 O    Sesame, oil                        0.450000   1.000      1.000   PP#6E7

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95003371 O    Sesame, oil-babyfood               0.450000   1.000      1.000   PP#6E7

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03003380 3    Shallot                            0.900000   1.000      1.000

26003390 M    Sheep, meat                        0.100000   1.000      1.000

26003391 M    Sheep, meat-babyfood               0.100000   1.000      1.000

26003400 M    Sheep, meat byproducts             0.200000   1.000      1.000

26003410 M    Sheep, fat                         0.100000   1.000      1.000

26003411 M    Sheep, fat-babyfood                0.100000   1.000      1.000

26003420 M    Sheep, kidney                      0.200000   1.000      1.000

26003430 M    Sheep, liver                       1.500000   1.000      1.000

06003470 6    Soybean, seed                      0.040000   1.000      1.000

06003480 6    Soybean, flour                     0.040000   1.000      1.000

06003481 6    Soybean, flour-babyfood            0.040000   1.000      1.000

06003490 6    Soybean, soy milk                  0.040000   1.000      1.000

06003491 6    Soybean, soy milk-babyfood or in   0.040000   1.000      1.000

06003500 6    Soybean, oil                       0.040000   1.000      1.000

06003501 6    Soybean, oil-babyfood              0.040000   1.000      1.000

95003520 O    Spearmint                          8.000000   1.000      1.000

95003530 O    Spearmint, oil                     8.000000   1.000      1.000

04013550 4A   Spinach                           11.770000   1.000      1.000

04013551 4A   Spinach-babyfood                  11.770000   1.000      1.000

09023560 9B   Squash, summer                     0.500000   1.000      1.000

09023561 9B   Squash, summer-babyfood            0.500000   1.000      1.000

09023570 9B   Squash, winter                     0.500000   1.000      1.000

09023571 9B   Squash, winter-babyfood            0.500000   1.000      1.000

95003590 O    Strawberry                         1.200000   1.000      1.000

95003591 O    Strawberry-babyfood                1.200000   1.000      1.000

95003600 O    Strawberry, juice                  1.200000   1.000      1.000

95003601 O    Strawberry, juice-babyfood         1.200000   1.000      1.000

20003640 20   Sunflower, seed                    0.300000   1.000      1.000   PP#6E7

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20003650 20   Sunflower, oil                     0.300000   1.000      1.000   PP#6E7

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20003651 20   Sunflower, oil-babyfood            0.300000   1.000      1.000   PP#6E7

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01033660 1CD  Sweet potato                       0.040000   1.000      1.000

01033661 1CD  Sweet potato-babyfood              0.040000   1.000      1.000

04023670 4B   Swiss chard                        5.020000   1.000      1.000

10003690 10   Tangerine                          2.000000   1.000      1.000

10003700 10   Tangerine, juice                   2.000000   2.300      1.000

01033710 1CD  Tanier, corm                       0.040000   1.000      1.000

08003740 8    Tomatillo                          1.400000   1.000      1.000

08003750 8    Tomato                             0.158000   1.000      1.000

08003751 8    Tomato-babyfood                    0.158000   1.000      1.000

08003760 8    Tomato, paste                      0.158000   2.100      1.000

08003761 8    Tomato, paste-babyfood             0.158000   2.100      1.000

08003770 8    Tomato, puree                      0.158000   0.550      1.000

08003771 8    Tomato, puree-babyfood             0.158000   0.550      1.000

08003780 8    Tomato, dried                      0.158000  14.300      1.000

08003781 8    Tomato, dried-babyfood             0.158000  14.300      1.000

08003790 8    Tomato, juice                      0.158000   1.500      1.000

15003810 15   Triticale, flour                   0.200000   1.000      1.000

01033870 1CD  Turmeric                           0.040000   1.000      1.000

01013880 1AB  Turnip, roots                      0.400000   1.000      1.000

05023890 5B   Turnip, greens                     5.740000   1.000      1.000

14003910 14   Walnut                             0.040000   1.000      1.000

86010000 O    Water, direct, all sources         0.002300   1.000      1.000

86020000 O    Water, indirect, all sources       0.002300   1.000      1.000

09013990 9A   Watermelon                         0.500000   1.000      1.000

09014000 9A   Watermelon, juice                  0.500000   1.000      1.000

15004010 15   Wheat, grain                       0.200000   1.000      1.000

15004011 15   Wheat, grain-babyfood              0.200000   1.000      1.000

15004020 15   Wheat, flour                       0.200000   0.700      1.000

15004021 15   Wheat, flour-babyfood              0.200000   0.700      1.000

15004030 15   Wheat, germ                        0.200000   0.850      1.000

15004040 15   Wheat, bran                        0.200000   1.000      1.000

01034060 1CD  Yam, true                          0.040000   1.000      1.000

01034070 1CD  Yam bean                           0.040000   1.000      1.000

Attachment 5.  Pyraclostrobin Chronic Dietary Analysis Results – Food & Water

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for PYRACLOSTROBIN                   (1994-98 data)

Residue file name: C:\DEEMFCID\Pyraclostrobin\PyraclostrobinTol+aveH2O.R98

                                                     Adjustment factor #2 used.

Analysis Date 02-11-2008/11:31:42     Residue file dated: 02-06-2008/14:23:05/8

Reference dose (RfD, Chronic) = .034 mg/kg bw/day

COMMENT 1: Food and drinking water

======================================================================== =======

                    Total exposure by population subgroup

------------------------------------------------------------------------ -------

                                                    Total Exposure

                                         -----------------------------------

          Population                         mg/kg             Percent of

           Subgroup                       body wt/day             Rfd

--------------------------------------   -------------       ---------------

U.S. Population (total)                     0.006149                18.1%

U.S. Population (spring season)             0.006294                18.5%

U.S. Population (summer season)             0.006226                18.3%

U.S. Population (autumn season)             0.005953                17.5%

U.S. Population (winter season)             0.006136                18.0%

Northeast region                            0.006459                19.0%

Midwest region                              0.005995                17.6%

Southern region                             0.005629                16.6%

Western region                              0.006862                20.2%

Hispanics                                   0.005993                17.6%

Non-hispanic whites                         0.006048                17.8%

Non-hispanic blacks                         0.006138                18.1%

Non-hisp/non-white/non-black                0.008219                24.2%

All infants (< 1 year)                      0.010702                31.5%

Nursing infants                             0.005616                16.5%

Non-nursing infants                         0.012632                37.2%

Children 1-6  yrs                           0.013276                39.0%

Children 7-12 yrs                           0.006963                20.5%

Females 13-19 (not preg or nursing)         0.003905                11.5%

Females 20+ (not preg or nursing)           0.005233                15.4%

Females 13-50 yrs                           0.004964                14.6%

Females 13+ (preg/not nursing)              0.004610                13.6%

Females 13+ (nursing)                       0.005972                17.6%

Males 13-19 yrs                             0.004768                14.0%

Males 20+ yrs                               0.005278                15.5%

Seniors 55+                                 0.005728                16.8%

Children 1-2 yrs                            0.016427                48.3%

Children 3-5 yrs                            0.012376                36.4%

Children 6-12 yrs                           0.007378                21.7%

Youth 13-19 yrs                             0.004347                12.8%

Adults 20-49 yrs                            0.004983                14.7%

Adults 50+ yrs                              0.005731                16.9%

Females 13-49 yrs                           0.004708                13.8%

------------------------------------------------------------------------ -------

Attachment 6.  Pyraclostrobin Chronic Critical Commodity Contribution Analysis – Food☠圠瑡牥഍敒敦敲据潤敳⠠晒ⱄ䌠牨湯捩
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                               Children 1-2 yrs

                 Total Exposure =.0164265 mg/kg bw/day

            Crop groups with total exposure contribution > 10%

              Foods/Foodforms with exposure contribution > 10%

------------------------------------------------------------------------ -------

Crop group                               ----------Exposure Analysis-------

   Food                                     mg/kg     % of Total   Percent

      Foodform                           body wt/day   Exposure    of RfD

--------------------------------------   -----------  ----------  ---------

Crop Group = (O)  Other

  Total for crop group                     0.0019810     12.06%       5.83%

Crop Group = (D)  Dairy Products

   Milk, water (27022240):

        FoodForm N/S                       0.0031545     19.20%       9.28%

--------------------------------------   -----------  ----------  ---------

  Total for crop group                     0.0036688     22.33%      10.79%

Crop Group = (11) Pome Fruits

  Total for crop group                     0.0018435     11.22%       5.42%

Total for crop groups listed above:        0.0074933     45.62%      22.0%

------------------------------------------------------------------------ -------

Pyraclostrobin	Dietary Exposure and Risk Assessment	DP Number: 348308

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Page   PAGE  9  of   NUMPAGES  34