GROUP 111: 100 mg/ rn3 ANIMAL DAYS OF GESTATION NUMBER 0 4 4 7 0 7 7 9 9 11 11 13 35580 195.2  13.9 181.3  20.7 39.0 41.9 35582  72.8 26.8  46.0 49.6 32.6 95.3 35587  127.7  187.8  315.5  44.5  88.9  9.3 35589  72.2  74.7  146.9 37.4 18.7 86.5 35594 114.4 15.9 130.3 20.7 56.4  29.5 35596 96.9 8.8 105.7  14.1 57.5 136.5 35609 123.7  54.0 69.7  19.4 21.9 49.7 35610 139.9  137.0 2.9 16.0 9.8 38.1 35611 29.3 62.4 91.7 52.7 5.2 36.4 35615 376.6 16.5 393.1 12.3 20.9 57.3 35622  53.3  3.5  56.8 23.3  26.3 32.0 35624  178.4 202.0 23.6  45.9 9.6 71.5 35627  10.3 48.6 38.3 7.5 17.7 57.4 35634  584.8 93.1  491.7  28.0 34.5 54.8 35641  54.7 29.2  25.5  18.2 6.4 50.7 35643 59.6 0.6 60.2  13.1  32.7 110.0 35645  94.1 19.8  74.3 8.2  23.6 77.7 35652 20.9  39.2  18.3 13.7  1117 75.3 35657  200.3 68.6  131.7  21.2 4.6 15.5 35660  58.7  28.7  87.4 55.6  41.1 35.7 35661  63.4 10.7  52.7  2.5 73.5 78.9 35662  44 * 5  10.0  54.5  7.5 49.9 86.2 DuPont 10657 13 15 ANIMAL STATUS 124.0 13.1  32.9 97.3 69.9  10.3 ED 23.5 87.3 99.2 74.8 115.7 66.1 76.9 30.2 78.5 47.6 48.5 28.0  21.7 NP 35.8 106.5 64.9 116 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicitv Study in Rabbits INDIVIDUAL BODY WEIGHT CHANGES ( grams)

GROUP 111: 100 mg/ m3 ANIMAL DAYS OF GESTATION NUMBER 15 17 17 19 19 21 21 23 23 25 25 27 35580  5.9 95.5  27.6 43.6 38.5 43.3 35582 84.1  62.3 63.5 54.0 95.3 46.7 35587 33.9 72.3 42.8 45.4 70.0 38.3 35589 21.3  18.0 68.8 35.1 37.5 78.9 35594  4.5  0.5 41.0 19.6 69.1 27.1 35596 53.2 80.4 23.0 22.5 66.3 10.7 35609 11.5  3.4 24.0 56.2 53.3  64.0 35610 5.3 26.4 38.4 45.4 50.9 111.9 35611 40.6  15.7 20.0 74.8 36.2  26.0 35615  25.8  14.7 32.3  2.8 86.3  26.1 35622 19.1 29.6  32.6 64.9  22.3  13.0 35624 29.5  34,2 28.1 36.2 48.0 10.0 35627  5.2  9.2 47.5 56.2 47.9  14.3 35634  25.1 68.8 128.8 48.8 28.5 27.8 35641  26.2 6.1 50.3 .21.1 109.5  21.1 35643  62.9 27.0 32.5 97.3 48.5 41.2 35645 10.3 73.7 57.1 16.6 73.2  0.5 35652  1.8 3.4 27.2 50.5 11.2 44.6 35657 32.4 64.4  122.2 45.4 0.5 59.2 35660 24.6 0.7  6.3 18.3  7.9 41.7 35661 29.8 34.5 49.4 38.8  3.4 51.7 35662 57.3 45.4 5.0 17.8 48.1 64.3 DuPont 10657 27 29 ANIMAL STATUS  8.5  12.8 14.6  52.0 33.2  256.8 ED 169.2 44.3  19.3 38.2 97.2 57.3 77.9 41.3  3.7 21.8 106.8 44.4 26.1 NP 25.7 24.2 23.5 117

 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 GROUP 111: 100 mg/ m3 ANIMAL NUMBER 7 29 35580 363.1 35582 459.1 35587 141.7 35589 411.5 35594 302.5 35596 168.9 35609 322.5 35610 473.8 35611 304.1 35615 252.7 35622 287.6 35624 276.2 35627 360.3 35634 410.4 35641 211.2 35643 317.2 35645 448.0 35652 284.8 35657 83.0 35660 182,8 35661 481.4 35662 454.9 INDIVIDUAL BODY WEIGHT CHANGES ( grams)

DAYS OF GESTATION 7 29a ANIMAL STATUS  101.3 27.6  298.5  87.8  29.5 ED  132.4 109.8  108.3  217.2  29.2  169.9  83.2  74.3  262.6  231.7  3.4  194.4 NP  2.4 79.5  39.6 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL BODY WEIGHT CHANGES ( grams)

GROUP IV: 300 rng/ m3 ANIMAL DAYS OF GESTATION NUMBER 0 4 4 7 0 7 7 9 9 11 35571  37.0 30.7  6.3  23.9 28.2 35577 44.5 37.4 81.9  53.1 45.5 35583 29.3 1.9 31.2  22.9 22.3 35586 174.0  77.3 96.7  81.3 35.0 35591 19.2 105.7 124.9 25.8 3.7 35592 103.5  94.7 8.8 0.5 58.2 35607 74.4  44.9 29.5  68.2  1.1 35608 8.4  2.0 6.4  14.4 37.5 35618  55.6 2.7  52.9 34.5  26.5 35620 152.3  24.8 127.5 68.4 12.6 35625 14.4 21.9 36.3  44.3 3.6 35626 82.5  23.2 59.3 0.1 58.6 35631 188.9 75.8 264.7  33.9 44.1 35635 76.8 9.7 86.5  24.7 10.9 35637 139.8  99.0 40.8 23.9 8.5 35640 83.1  51.9 31.2  27.3  32.3 35650  16.1 83.1 67.0  168.7 81.5 35653  34.2 39.3 5.1  18.9 37.2 35663  93.1 57.8  35.3 27.1  21.5 35672  279.3 63.6  215.7 3.5  8.6 35676  76.1 5.6  70.5 5.2  15.2 35678  7.9 4.0  3.9 0.3  27.0 11 13 13 15 ANIMAL STATUS 23 6 78.4 71.5 53.1 60.1 52.4 61.4 79.7 74.5 165.6 0.2 48.1 30.7 141.5 34.8 77.6 17.2 71.1 141.1 25.8 52.8 97.6 24.3 80.6  76.6 117.1 61.5 93.9 82.2  11.3 76.1 60.3  16.5 53.2 139.0 25.3 164 4 38.2 118.8  14.2 27.0 19.3 33.1 9.1 NP 119 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL BODY WEIGHT CHANGES ( grams)

GROUP IV: 300 mg/ m3 ANIMAL DAYS OF GESTATION NUMBER 15 17 17 19 19 21 21 23 23 25 25 27 27 29 ANIMAL STATUS 35571 99.9 4.3 27.9 26.9 64.1 72.2 23.0 35577 23.0 37.7 54.7 79.2 8.2 7.0 17.8 35583  11.4 52.7 57.8 55.9 31.4 67.4 21.3 35586  27.8  31.4 28.5 47.5 47.7 38.6 0.9 35591 79.9 9.6 29.2 46.0 25.4 31.0  75.7 35592 12.3  7.1 60.0 74.1 75.0 85.7  0.3 35607 19.9 9.0 24.0 84.1 39.2  2 * 1 156.4 35608 3.5  42.8 27.8 31.3 75.8 39.3 70.6 35618  49.6 14.8 42.9  1.1 42.4 6.8 27.0 3 562 0  159.1 111.2 83.2 9.9 43.0 72.8  53.8 35625  33.3 55.6 8.2 83.3 17.6 31.4  11.3 35626  5.4  3.7 23.0 30.0 89.2 30.4 41.2 35631 8.5  18.3 31.8  5.0 28.4 31.0 21.2 35635  0.6 61.3 20.4 60.1 57.9 24.7 13.4 35637  9.5 38.6 44.4 35.1 28.1 44.7 40.2 35640  59.1 22.6 39.2 48.6 72.3  4.0 33.0 35650 54.9 1.1 27.8 94.3 117.7  18.8 24.7 35653  17.3  16.9 88.0 34.1 11.7 7.6 0.9 35663  77.3 9.1 17.9  0.1 96.9 7.0 107.8 35672  9.5 14.5  107.7  208.7 360.3 49.3 25.3 35676 27.9  15.5 47.9 54.0 7.. 6 51.9 38.6 35678  39.4 35.8 4.7 19.1  19.8 35.8 7.8 NP 120  Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL BODY WEIGHT CHANGES ( grams)

GROUP IV: 300 mg/ m3 ANIMAL DAYS OF GESTATION NUMBER 7 29 7 29a ANIMAL STATUS 35571 424.6  261.8 35577 344.6  85.1 35583 387.0  36.7 35586 198.8  252.1 35591 415.0  121.5 35592 406.7  207 7 35607 433.4  242.3 35608 341.0  200.8 35618 179.5  126.7 35620 355.1  80.6 35625 261.2  172.7 35626 368.3  59.1 35631 148.3  336.2 35635 378.8  66.5 35637 324.9  128.1 35640 229.4  173.6 35650 251.2  232.6 35653 290.7  276.3 35663 369.5  80.3 35672 223.0  132.8 35676 248.7  76.3 35678 59.5 NP 121   Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL BODY WEIGHT CHANGES ( grams)

GROUP v: 1000 mg/ m3 ANIMAL DAYS OF GESTATION NUMBER 0 4 4 7 0 7 7 9 9 11 11 13 13 15 ANIMAL STATUS 35569 177.8  5.5 172.3 4.2  8.6 75.0 18.8 35575 56.9  14.7 42.2 48.0 94.3 FD 35581 7.9 39.9 47.8 12.6  5.3 39.5 88.8 35590  104.4  73.5  177.9 102.8  43.6 54.7 18.8 R 35598 39.3  79.9  40.6  9.1 52.4 75.0 45.6 35602 70.4  13.1 57.3  6.3 0.7 69.0 21.3 35605 139.1  20.6 118.5  60.2 1.0 36.8 58.5 35612 173.1  31.9 141.2 16.2 0.4 4.2 4.3 NP 35613  572.6 262.6  310* 0  375.9  78.2  124.9  5.7 35619  44.2  55.1  99.3 77.7  3.0  9.2 65.8 35623  97.7 34.0  63.7 66.3  16.5  9.2 47.0 35629  15.3 28.3 13.0  17.3  3.2  1.5 32.2 35636 61.9  4.1 57.8  54.3 30.2 41.6 31.4 35638  25.2 52.8 27.6  72.1 62.3 88.5 105.9 35648 8.4 43.4 51.8  52.8 63.3 4.0 72.5 35651  42.7 41.7  1.0  266.1 129.6 43.4 53.9 35655  167.6  21.4  189.0 104.7  40.6 36.7 68.1 35664  21.9 10.9  11.0 44.5  22.7 98.2 99.7 35665 56.0  1.5 54.5 9.7 21.4 88.1  18.5 35668 15.0 28.6 43.6 85.5  34.6 100.6  21.9 35671  39.0 9.6  29.4  29.6 18.4  48.6  131.9 SE 35673 41.0  59.6  18.6 42.6  11.1 65.5 44.7 122

 Dimethvl Glutarate ( DMG): Inhalation DeveloDmental Toxicity Studv in Rabbits DuPont 10657 INDIVIDUAL BODY WEIGHT CHANGES ( grams)

GROUP v: 1000 mg/ m3 ANIMAL DAYS OF GESTATION NUMBER 15 17 17 19 19 21 21 23 23 25 25 27 27 29 ANIMAL STATUS 35569 45.3  0.6 20.4 63.1  26.6 50.1 6.7 35575 FD 35581  19.3 2.1 49.1 29.8 63.7 1.5 14.5 35590 35.9 13.7 28.7 67.8 57.4 78.1  128.5 R 35598 35.6  37.3  187.2 275.2 42.6  5.7 40.0 35602  29.3  371.1  96.9 119.3 301.9 52.5 13.6 35605 49.8 6.4  136 9 273.3 3.5 37.8 52.8 35612 54.2 47.4  184.8 168.8 64.0  50.6 64.8 NP 35613 240.6 154.2 34.0  40.7  139.6 211.3 39.4 35619 35.2 4.6 35.5 52.8  151.9 253.3  2.9 35623 4.5 9.2 57.0  76.4  78.6 201.1 27.0 35629 41.5 36.8 118.1  59.7  153.9 265.2  9.2 35636 42.8 40.7 2.6  0.8  24.5 58.9  1.8 35638  11.3 2.9 26.6 28.4 60.5 25.9 52.5 35648  8.0 6.4 4.0 39.9 1.1 4.8 11.6 35651  11.1 7.8 12.7 41.1 28.3  9.6 65.6 35655 92.7  57.5 145.1  56.7 42.8  18.4  23.2 35664  16.3 16.3 34.4 45.1 6.8  0.9 11.5 35665 51.7 1.7 66.0 77.3 22.5 39.6 37.8 35668 71.9 1.7 9.7 44.2 28.8 17.6 42.7 35671  284.2  88.7  209.3 SE 35673 17.8 20.2  7.7 27.5  8.8 24.2  15.5

 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 GROUP v: 1000 mg/ m3 ANIMAL NUMBER 7 29 35569 247.8 35575 35581 277.0 35590 285.8 35598 327.1 35602 74.7 35605 322.8 35612 188.9 35613  85.5 35619 357.9 35623 231.4 35629 249.0 35636 166.8 35638 370.1 35648 146.8 35651 95.6 35655 293.7 35664 316.6 35665 397.3 35668 346.2 35671 35673 199.4 INDIVIDUAL BODY WEIGHT CHANGES ( grams)

DAYS OF GESTATION 7 29a ANIMAL STATUS  112.2 FD  142.2  219.5 R  36.7  279.4  31.4 NP  439.0  161.5 20.7  106.9 101.7  26.3  195.8  92.3  139.8  115.9  44.4  211.4 SE 5.9 124 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 APPENDIX G Individual Food Consumption 125  Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 Individual Food Consumption Explanatory Notes Abbreviations = No data AB = Aborted NP = Not pregnant ED = Earlydelivery R = Litter totally resorbed SE = Sacrificed in extremis FD = Founddead 126 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits INDIVIDUAL FOOD CONSUMPTION ( grams/ day)

GROUP I: o mg/ m3 ANIMAL DAYS OF GESTATION NUMBER 4 7 7 9 9 11 11 13 13 15 15 17 35570 147.3 152.9 151.5 150.5 150.4 151.9 35572 150.6 150.1 152.2 149.5 148.8 153.7 35576 127.6 150.5 149'. 0 151.7 148.1 150.5 35578 148.2 152.3 151.4 154.3 152.2 152.3 35579 149.2 151.2 148.9 151.4 149.9 153 9 35597 152.7 154.1 149.4 150.6 152.5 154.5 35599 124.4 84.5 151.5 149.9 152,9 152.8 35601 150.7 152.8 149.4 149.9 153.9 151.9 35604 152.5 152.4 149.8 149.6 152.0 149.9 35616 150.5 150.4 149.1 151.0 152.4 150.4 35621 149.0 150.3 147.8 146.7 125.8 150.4 35628 151.1 152.3 154.0 152.2 154.1 151.0 35632 151.7 150 9 153.9 151.9 148.9 147.1 35639 150.4 149.2 152.1 119.2 86.9 114.4 35644 150.5 150.9 150.5 147.5 152.7 149.6 35646 150.7 102.8 90.6 85.7 113.3 150.8 35656 151.1 151.9 151.5 153.1 153.6 145.7 35658 152.3 151.8 152.0 152.7 152.7 150.3 35659 150.3 153.7 148.7 149.8 149.1 148.4 35666 152.5 151.8 150.6 152,9 152.8 148.3 35675 150.3 153.4 148.2 152.5 151.0 153.1 35677 150.2 151.6 151.8 150.3 152.7 152.9 DuPont 10657 17 19 ANIMAL STATUS 149.9 153.9 152.6 150.7 AB 148.8 151.8 151.1 148.9 148.3 149.9 150.8 149.3 151.4 142.8 148.9 139.4 150.8 151.5 151.7 150.0 153.1 152.1    Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FOOD CONSUMPTION ( grams/ day)

GROUP I: o mg/ m3 ANIMAL DAYS OF GESTATION NlJMBER 19 21 21 23 23 25 25 27 27 29 7 29 ANIMAL STATUS 35570 149.0 151.7 148.7 151.2 151.2 150.8 35572 151.0 147.8 150.2 152.3 146.6 150.5 35576 153.2 152.1 149.2 148.6 150.5 150.5 35578 AB 35579 150.9 153.1 150.0 151.6 148.8 150.8 35597 148.1 152.6 150.4 150.5 149.9 151.3 35599 148.9 151.4 152.1 151.6 150.0 145.2 35601 149.4 153.1 150.1 148.4 151.6 150.8 35604 148.2 151.2 149.9 150.3 150.8 150.2 35616 152.4 153.6 151.0 152.6 149.5 151.1 35621 148.3 151.2 149.9 149.4 151.1 147.4 35628 149.9 148.6 148.6 153.4 151.2 151.3 35632 151.2 147.3 150.3 151.7 150.2 150.4 35639 150.0 148.5 152.2 149.4 129.3 135.8 35644 153.3 151, O 152.6 151.4 150.8 , 150.8 35646 150.3 149.3 153.5 150.8 148.1 130.4 35656 149.6 151.9 152.7 149.2 147.5 150.7 35658 152.0 151.4 153.1 146.7 149.9 151.3 35659 150.3 154.9 151.1 149.0 149.0 150.5 35666 151.8 147.4 148.4 149.9 152.3 150.6 35675 147.9 152.0 152.2 151.9 152.5 151.6 35677 151.4 149.6 155.2 153.3 153.1 152.2 128 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits INDIVIDUAL FOOD CONSUMPTION ( grams/ day)

GROUP 11: 30 mg/ m3 ANIMAL DAYS OF GESTATION NUMBER 4 7 7 9 9 11 11 13 13 15 15 17 35573 148.0 151.9 153.0 152.2 153.1 152.1 35574 140.1 149.1 150.7 153.1 150.6 151.8 35584 150.6 153.2 151.4 152,4 148.4 154.4 35585 152.4 152.9 152.8 154.1 148.4 150.8 35588 151.2 150.7 149.3 151.5 152.1 151.1 35593 152.3 152.4 147.1 154.2 151.8 152, l 35595 151.9 153.0 149.0 148.8 149.0 152.1 35600 150.7 152.5 151.2 150.1 150.9 151.4 35603 151.8 151.4 150.8 152.9 153.8 150.0 35606 152.6 152.0 151.4 149.4 152.8 151.6 35614 150.7 151.1 153.2 151.8 152.8 153.5 35617 147.8 149.3 152.6 150.5 148.7 149.6 35630 150.2 150.3 150.9 149.7 150.8 151.6 35633 151.2 152.1 152.9 150.8 151.3 150.6 35642 152.0 148.7 151.2 152.0 151.2 153.7 35647 150.8 147.9 149.5 152.4 151.7 ' 149.4 35649 152.3 153.7 149.3 150.1 90.6 121.7 35654 152.8 150.0 147.1 151.5 151.8 151.0 35667 150.7 150.4 149.4 153.6 150.9 151.3 35669 151.7 153.6 151.9 152.5 150.4 149.9 35670 151.9 151.5 151.2 150.1 153.1 148.5 35674 152.4 153.1 153.7 152.6 152.6 114.1 DuPont 10657 17 19 ANIMAL STATUS 153.4 149.6 153.7 153.4 151.2 152.9 149.6 152.8 153.7 NP 152.1 148.8 153.4 149.8 152.6 149.8 150.7 149.5 151.2 NP 148.1 150.6 150.9 90.1 129 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FOOD CONSUMPTION ( grams/ day)

GROUP 11: 30 mg/ m3 ANIMAL DAYS OF GESTATION NUMBER 19 21 21 23 23 25 25 27 27 29 7 29 ANIMAL STATUS 35573 153.1 120.1 151.9 152.9 149.6 149.4 35574 151.2 151.1 151.3 150.8 148.9 150.7 35584 149.3 150.6 150.4 147.9 148.5 150.9 35585 148.1 149.3 152.6 91.8 149.1 145.7 35588 152.1 151.4 149.4 147.4 151.8 150.7 35593 151.0 152.1 149.6 146.7 149.3 150.8 35595 153.2 153.5 151.2 148.1 149.7 150.6 35600 146.6 152.1 146.4 147.5 151.2 150.2 35603 149.4 149.8 151.1 152.0 146.3 151.0 NP 35606 151.9 152.1 138.8 150.3 149.7 150.2 35614 149.8 153.9 150.1 151.0 147.7 151.2 35617 151.4 151.6 151.9 151.4 147.7 150.7 35630 152.1 151.2 152.3 149.7 147.8 150.5 35633 149.2 152.9 150.2 150.1 122.3 148.6 35642 149.4 152.8 150.9 146.2 148.6 150.4 35647 150.9 148.8 153.2 152.3 150.4 150.6 35649 153.9 152.2 150.6 150.8 148.6 142.8 35654 153.6 151.1 151.9 150.2 149.6 150.8 NP 35667 152.4 151.3 151.0 148.7 151.8 150.8 35669 148.6 153.0 149.6 151, l 150.9 151.1 35670 150.3 149.6 153.9 148.6 150.6 150.7 35674 97.0 152.9 152.1 149.7 146.8 137.7 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FOOD CONSUMPTION ( grams/ day)

GROUP 111: 100 mg/ m3 ANIMAL DAYS OF GESTATION NUMBER 4 7 7 9 9 11 11 13 13 15 15 17 17 19 ANIMAL STATUS 35580 147.4 148.1 151.2 119.0 150.6 152.7 148.7 35582 148.6 150.1 149.9 151.5 150.5 151.6 149.8 35587 105.5 32.3 16.5 1.3 16.3 45.1 74.6 35589 152.1 153.8 148.9 153.6 151.1 153.4 149.8 35594 151.4 151.8 151.3 151.0 152.0 153.6 153.7 35596 151.2 153.7 151.6 149.7 153.5 152.2 148.1 ED 35609 152.2 153.6 149.9 153.1 149.6 153.2 152.0 35610 148,6 154.1 150.1 152.6 150.1 153.6 152.1 35611 152.8 153.4 151.9 152.8 152.9 151.4 150.4 35615 153.4 149.4 152.4 152.1 152.6 153.8 147.6 35622 153.0 149.9 150.3 149.4 152.8 152.5 147.8 35624 123.2 148.6 151.4 145.5 151.9 151.1 151.1 35627 152.3 150.9 153.4 148.8 151.9 150.9 150.4 35634 151.8 153.6 151.4 153.6 151,7 150.4 151.6 35641 151.2 153.8 149.8 153.8 153.9 151.0 149.5 35643 153.5 152.1 149.9 154.8 151.3 148.8 153.2 35645 116.4 150.4 151.6 152.2 154.6 147.2 152.6 35652 149.4 149.8 152.8 149.9 150.9 149.5 150.2 35657 151.8 151.3 149.4 151.5 151.1 147.2 150.5 NP 35660 153.6 153.2 152.1 149.7 147.3 153.9 149.4 35661 151.5 153.8 149.7 152.6 151.0 148.4 151.4 35662 150,6 151.7 148.4 152.4 151.4 148.3 147.8 131 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FOOD CONSUMPTION ( grams/ day)

GROUP 111: 100 mg/ m3 ANIMAL DAYS OF' GESTATION NUMBER 19 21 21 23 23 25 25 27 27 29 7 29 ANIMAL STATUS 35580 150.1 153.0 146.9 149.1 153.7 147.5 35582 150.4 149.4 149.2 151.6 153.7 150.7 35587 112.3 140.1 151.5 152.6 151.1 81.2 35589 150.3 149.2 147.0 149.9 152.6 150.8 35594 150.9 148.5 151.9 150.4 147.6 151.1 35596 149.5 150.9 151.5 151.5 153.7 151.4 ED 35609 153.6 147.6 149.7 149.0 150.4 151.0 35610 152.6 149.4 151.1 150.3 154.1 151.8 35611 150.1 151.1 150.8 150.4 150.9 151.5 35615 151.3 152.6 150.7 147.2 150.8 151.0 35622 152.0 149.7 149.7 152.0 149.5 150.5 35624 149.4 152.0 147.5 150.9 152.9 150.2 35627 148.5 149.7 149.0 151.2 152.2 150.6 35634 150.6 149.8 146.5 153.1 148.8 151.0 35641 129.3 151.9 149.0 152.1 149.9 , 149.4 35643 149.9 151.2 151.9 151.1 151.6 151.4 35645 151.8 149.6 153.1 151.6 151.8 151.5 35652 150.4 151.4 146.8 150.1 151.1 150.3 35657 153.9 149.6 151.4 152.3 150.1 150.7 NP 35660 152.3 149.9 151.0 153.0 148.9 151.0 35661 150.1 150.6 150.9 151.8 150.5 151,0 35662 153.7 152.4 148.3 148.9 153.2 150.6 132 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits INDIVIDUAL FOOD CONSUMPTION ( grams/ day)

GROUP IV: 300 mg/ m3 15 17 151.7 153.0 150.1 152.3 148.6 152.9 151.6 153.3 148 4 149.5 148.2 152.9 152.4 149.9 146.7 ' 148.9 153.3 139.3 153.8 150.2 128.9 150.8 DuPont 10657 17 19 ANIMAL STATUS 152.9 151.3 151.2 149.8 149.9 152.3 151.1 148.0 147.8 148.3 153.8 151.3 150.2 151.9 152.4 151.6 150.5 152.5 153.2 147.7 150.1 151.7 NP ANIMAL NUMBER 4 7 7 9 9 11 11 13 13 15 35571 150.8 152.7 151.9 151.9 151.6 35577 152.0 154.5 150.4 153.0 150.2 35583 140.6 104.8 149.9 152.1 151.3 35586 153.0 149.9 149.4 152.7 151.1 35591 153.1 150.9 151,4 148.8 152.0 35592 151.3 130.3 150.8 149.4 151.9 35607 151.5 149.0 150.6 151.7 152.0 35608 152.1 130.9 150.6 149.3 151". 4 35618 151.5 146.8 150.4 149.9 151.9 35620 151.2 115.9 152.1 152.7 152.0 35625 150.6 140.7 150.1 149.8 152.1 35626 149.4 135.1 153.0 147.1 152.1 35631 152.9 138.9 150.5 150.4 153.7 35635 152.5 150.7 149.9 153.7 151.8 35637 151.6 152.4 151.7 153.9 153.9 35640 146.9 128.3 146.8 150.5 131.4 35650 150.6 52.3 150.1 149.9 150.3 35653 149.8 118.4 149.3 153.8 154.2 35663 152.1 148.9 153.8 150.3 132.9 35672 152.0 154.0 152.1 151.2 142.1 35676 153.2 135.1 151.9 150.0 118.7 35678 151.9 135.7 150.7 152.4 151.9 DAYS OF GESTATION Dimethyl Glutarate ( DMG): Inhalation DeveloDmental Toxicity Study in Rabbits DuPont 10657 GROUP IV: 300 mg/ m3 ANIMAL NUMBER 19 21 35571 149.9 35577 151.9 35583 153.0 35586 147.8 35591 152.0 35592 151.0 35607 150.4 35608 152.4 35618 148.6 35620 150.7 35625 151.8 35626 151.9 35631 151.7 35635 149.1 35637 153.6 35640 149.8 35650 150.6 35653 150.0 35663 151.4 35672 120.4 35676 153.6 35678 151.3 INDIVIDUAL FOOD CONSUMPTION ( grams/ day)

DAYS OF GESTATION 21 23 23 25 25 27 27 29 7 29 ANIMAL STATUS 149.7 152.6 152.4 149.9 151.5 152.8 152.5 153.9 150.3 152.2 150.8 151.9 150.8 150.8 147.0 148.3 154.3 151.4 149.7 150.6 153.4 151.6 149.1 150.6 150.7 151.5 151.9 147.8 148.2 148.9 151.7 151.2 152.3 153.4 151.4 152.5 151.4 151.7 149.9 149.2 148.2 151.2 152.3 152.7 149.8 152.4 151.8 148.3 151.2 147.7 151.5 152.2 150.9 152.9 150.3 152.4 147.0 150.0 149.0 149.2 151.4 148.3 150.1 151.9 149.9 148.2 147.0 152.0 151.4 150.5 147.4 150.2 150.5 152.9 151.4 152.1 150.3 152.1 112.2 143.1 149.3 150.3 152.0 147.3 141.4, 151.2 121.8 128.8 120.4 140.0 151.0 152.6 151.2 149.6 149.9 94.6 150.9 150.1 147.9 141.9 152.6 151.8 149.2 149.8 144.7 151.3 149.0 149.5 153.2 149.7 NP 134    Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FOOD CONSUMPTION ( grams/ day)

GROUP v: 1000 mg/ m3 ANIMAL DAYS OF GESTATION NUMBER 4 7 7 9 9 11 11 13 13 15 15 17 17 19 ANIMAL STATUS 35569 152.1 122.2 150.3 152.9 148.3 148.7 149.9 35575 150.9 138.9 147.4 76.6 FD 35581 152.6 126.5 148.0 150.4 131.6 147.8 151.5 35590 149.3 115.4 148.4 150.3 151.6 148.4 150.9 R 35598 151.1 148.5 147.8 151.2 151.3 150.4 148.3 35602 152.2 114.8 147.1 152.4 125.0 97.1 4.9 35605 151.0 90.2 146.8 150.8 150.0 150.2 150.7 35612 149.6 151.0 149.2 149.6 150.3 151.8 150.9 NP 35613 138.9 22.9 5.8 11.1 19.5 83.6 148.5 35619 149.5 140.7 149.2 148.3 150.1 152.0 149.9 35623 151.8 146.2 149.1 148.6 152.2 151.6 148.7 35629 151.8 151.6 122.0 152.5 152.7 152.1 150.4 35636 153.3 73.9 147.7 152.1 150.1 150.7 152.8 35638 152.2 77.4 135.1 148.8 151.9 149.4 148.6 35648 152.3 80.1 153.1 150.6 150.3 150.4 150.6 35651 151.6 22.7 151.9 152.4 153.0 ' 146.7 152.4 35655 151.7 143,6 149.1 150.1 148.3 154.0 148.8 35664 152.6 121.3 150.8 152.5 151.5 151.8 151.1 35665 152.2 129.8 151.8 151.1 151.2 148.8 146.6 35668 151.7 103.5 153.7 153.4 151.0 151.2 148.3 35671 150.5 100.7 153.7 152.8 140.8 2.2 0.8 SE 35673 152.9 134.3 149.0 151.6 152.1 151.4 149.0 135

  Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FOOD CONSUMPTION ( grams/ day)

GROUP V: 1000 mg/ m3 ANIMAL DAYS OF GESTATION NUMBER 19 21 21 23 23 25 25 27 27 29 7 29 ANIMAL STATUS 35569 148.3 149.0 147.6 148.9 145.9 146.5 _

_ FD R NP SE 35575 35581 35590 35598 35602 35605 35612 35613 35619 35623 35629 35636 35638 35648 35651 35655 35664 35665 35668 35671 35673 __ 149.4 153.6 148.2 144.5 147.6 152.4 76.0 139.0 147.8 148.9 153.6 148.0 146.1 150.5 151.4 111.9 150.4 150.0 145.9 141.3 149.3 152.8 151.4 150.6 148.2 149.7 149.6 94.3 113.2 153.2 149.3 145.6 153.3 149.1 150.4 149.7 147.6 151.1 150.2 148.0 148.3 146.9 148.5 142.6 124.3 151.6 149.5 139.7 102.1 150.7 149.8 139.2 124.1 149.6 146.0 135.9 147.1 149.5 148.2 149.0 111.0 114.1 78.6 134.8 147.7 150.4 148.1 147.7 153.9 149.4 149.5 146.5 149.1 146.2 133.0 45.4 118.4 149.4 150.0 150.8 148.8 150.4 146.5 150.2 149.6 148.9 148.3 150.9 148.6 150.3 2.5 147.3 133.5 142.4 147.8 96.6 150.6 150.6 148.3 145.5 149.5 147.4 151.2 149.8 143.6 147.9 152.2 149.4 150.4 147.0 _

148.9 148.9 151.7 151.8 151.4 Dimethvl Glutarate ( DMG): Inhalation Develor> mentalToxicitv Studv in Rabbits DuPont 10657 APPENDIX H Individual Clinical Observations 137 Dimethvl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 Individual Clinical Observations Explanatory Notes Footnotes a The first observation recorded each day ( in the morning) is indicated by   a,  the second by   b.  Twice daily observations were made on days 7 286. If no signs were observed during the study examinations, the   b  entries are omitted from the printout.

A post exposure clinical observation was inadvertently not recorded for one animal ( Animal Number 35633) on one day ( July 4,2002). This protocol deviation did not adversely impact the study because it affected one animal for one day and clinical observations were recorded pre exposure and for all subsequent protocol specified times.

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PP rP3 ii ._.___.... PP P . I1 II m I1 ii  _... ........ d II ................ ( dQ ( dQ ( dQ ( d ( d  11 ........ w . c N 0 \ m rl \ P 0 crl H E ..... ............. ..... ............. ..

.......... ( dQ ( dQ ( dQ ( dQ ( d ( d ( d ( d ( d an 6~ ( 6 N 0 N \ 0 N \

rl mrl \ r 0 m In m m m Dimethvl Glutarate ( DMG): Inhalation Develo~ mentalToxicitv Studv in Rabbits DuPont 10657 APPENDIX I Gross Postmortem Findings 155  Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 Gross Postmortem Findings Explanatory Notes Abbreviations AB = Aborted NP = Notpregnant ED = Earlydelivery R = Litter totally resorbed SE = Sacrificed in extremis FD = Founddead = No data NAD = No abnormalities detected 156 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 GROSS POSTMORTEM FINDINGS Group I: 0 mg/ m3 Animal Animal Number Status Structure( s) 35570 35572 35576 35578 AB 35579 Lungs 35597 Lungs 35599 35601 35604 35616 35621 35628 35632 35639 35644 35646 35656 35658 35659 35666 35675 35677 Findinn( s)

NAD NAD NAD NAD Discoloration; red mottling left lobe Discoloration; red mottling all lobes NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD 157 DuPont 10657Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits GROSS POSTMORTEM FTNDINGS Group 11: 30 mg/ m3 Animal Animal Number Status S tructure( s2 35573 35574 35584 35585 35588 35593 35595 35600 35603 NP 35606 35614 35617 35630 35633 35642 35647 35649 35654 NP 35667 35669 35670 35674 Findinn( s2 NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 GROSS POSTMORTEM FINDINGS Group III: 100 mg/ m3 Animal Animal Number Status 35580 35582 35587 35589 35594 35596 ED 35609 35610 35611 35615 35622 35624 35627 35634 35641 35643 35645 35652 35657 NP 35660 35661 35662 Structure( s1 Finding( s)

NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 GROSS POSTMORTEM FINDINGS Group IV: 300 mg/ m3 Animal Animal Number Status Structure( s) Finding( s)

3557 1 35577 35583 35586 35591 35592 35607 35608 35618 35620 35625 35626 35631 35635 35637 35640 35650 35653 35663 35672 35676 35678 NP NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD 160 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 GROSS POSTMORTEM FINDINGS Group V: 1000mg/ m3 Animal Animal Number Status Structure( s) 35569 35575 FD 35581 35590 R 35598 35602 35605 35612 NP 35613 35619 35623 35629 35636 35638 35648 35651 35655 35664 35665 35668 3567 1 SE Gallbladder 35673 Finding( s)

NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD Large; 5.0 X2.0 cm NAD Dimethvl Glutarate ( DMG): Inhalation Develo~ mentalToxicitv Studv in Rabbits DuPont 10657 APPENDIX J Individual Reproductive Data 162  Dimethyl Glutarate ( DMG): Inhalation DevelopmentalToxicity Study in Rabbits DuPont 10657 Individual Reproductive Data Explanatory Notes Abbreviations AB = Aborted NP = Not pregnant ED = Early delivery R = Litter totally resorbed SE = Sacrificed in extremis FD= Found dead

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h PI W pl z m v v v  > cn d 0 co m In m m cn m cn W co co d In w In a) d m 5 W a3 m cn 0 0 rl d rl ( u ( u m m cy In In W W W r r In In m In W W W W W v, W W W W W W W W W W W E m In In In m In ul In In m In ul In m In m In ul In In In m m W m m m m m m m m m m m m m m m m m m 2 I Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 APPENDIX K Individual Fetal Weights and Alterations 169  Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 Individual Fetal Weights and Alterations Explanatory Notes For ease of recording, many of the findings have been abbreviated or coded, as listed below: ar = Arch( es) bil = Bilateral cen = Centrumorcentra It = Left lu = Lumbar NAD = No abnormalities detected rt = Right th = Thoracic = No data * Subcutaneous hemorrhage that was not present in utero.

Renal papillary sizes refer to papillary development using the scheme of Woo and Hoar.( 3)

Alterations are classed as: N = Notes DV = Developmental Variations VR = Variation due to Retarded Development M = Malformations Numbers are used to:

0 Indicate renal papillary size 0 Identify specific sternebra 0 Refer to skeletal position for ribs or vertebra 0 Specify skull bones according to the following key: 1. Interparietal 8. Squamosal 2. Parietal 9. Tympanic annulus 3. Frontal 10. Basioccipital 4. Nasal 1 1. Exoccipital 5. Premaxilla 12. Supreoccipital 6. Maxilla 13. Hyoid 7. Zygoma 170 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS CLASSIF STRUCTURE FINDING( S) ICATION GROUP I: 0 mg/ m3 DOE #/ FETUS # FETUS WT 35570 1 36.70 2 30.80 3 34.82 4 35.19 5 35.72 6 31.06 7 30.32 8 23.36 35572 1 47.91 2 48.29 3 47,03 4 44* 97 5 40.76 6 41.75 35576 1 49.10 2 40.98 3 40.82 4 38.44 5 43.90 6 42.85 7 33.29 8 34.98 9 39.85 10 45.55 Rib Rib Rib Sternebra Rib Rib Sternebra Rib Rib Skull Kidney Rib Sternebra Skull Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Supernumerary ( th13 full bill DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Retarded Ossification ( 6) VR Supernumerary ( th13 full bil) DV Supernumerary ( th13 short It full rt) DV Retarded Ossification ( 6) VR Supernumerary ( th13 short bil) DV Supernumerary ( th13 short rt full It) DV Retarded Ossification ( 2 It) VR Papilla  Size 3 ( RT) VR Supernumerary ( th13 full bill DV Retarded Ossification ( 6) VR NAD NAD Retarded Ossification ( 7 It) VR Supernumerary ( th13 short It) DV NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 short bill DV Supernumerary ( th13 site It) DV Supernumerary ( th13 short bill DV NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bill DV Supernumerary ( th13 full bil) DV 17 1 1 2 3 4 5 6 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP I: o mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35579 1 2 3 4 5 41.28 35.56 30.36 20.23 20.38 Rib Rib Rib Kidney Rib Rib Pelvis Supernumerary ( th13 full bill Supernumerary ( th13 full bil) Supernumerary ( th13 full bill Papilla  Size 3 ( bil) Supernumerary ( th13 short It) Supernumerary ( th13 full It) Retarded Ossification DV DV DV VR DV DV 6 20.92 Rib Pelvis Supernumerary ( th13 full bil) Retarded Ossification ( pubis bil) VR DV 7 8 9 10 11 12 29.23 44.26 23.86 26.35 24.57 28.03 Rib Rib Rib Rib Rib Skull Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Retarded Ossification ( 7 It) Supernumerary ( th13 full bil) ( pubis bil) VR DV DV DV DV DV VR DV 35597 46.31 NAD 42.55 NAD 40.86 37.50 Rib Rib Supernumerary ( full 13 bil) Supernumerary ( full 13 bill DV DV 40.72 Rib Supernumerary ( short 13 rt) DV 43.50 Rib Supernumerary ( full 13 bill DV Pelvis Retarded Ossification ( pubisbi1) VR 7 42.19 NAD 8 39.68 Rib Supernumerary ( full 13 bil) DV 9 37.56 Rib Supernumerary ( full 13 bil) DV 35599 1 46.82 NAD 2 35.22 NAD 3 4 28.55 31.56 Rib Rib Supernumerary ( th13 short rt) Supernumerary ( th13 full bil) DV DV 172 1 2 3 4 5 6 7 8 9 10 1 2 3 4 5 6 7 1 2 3 4 5 6 7 8 ' I Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP I: o mg/ m3 DOE #/ CLASS1F FETUS # FETUS WT STRUCTURE FINDING( S) ICATION ~

35599 ( Cont.) 5 37.64 6 41.11 7 41.89 8 40.00 9 35.88 35601 40.89 38.91 41.45 38.57 41.57 47.39 39.36 37.25 30.38 30.00 35604 51.10 46.47 48.37 50.10 35.37 45.90 37.93 35616 51.17 48.14 39.24 42.25 54.21 49.28 47.33 42.99 Rib Rib Rib Kidney Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD NAD NAD Supernumerary ( th13 short rt) DV NAD Papilla  Size 3 ( rt) VR Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 short bil) DV NAD NAD Supernumerary ( th13 full rt) DV Supernumerary ( th13 full It) DV NAD Supernumerary ( th13 full bill DV Supernumerary ( th13 It short) DV Supernumerary ( th13 full bill DV NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD NAD NAD 173 1 2 3 4 5 6 7 8 9 10 11 12 1 2 3 4 5 6 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP I: o mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35621 45.17 40.15 51.28 40.68 38.81 35.38 35.03 28.20 31.76 37.32 26.63 36.23 35628 26.89 33.45 53.59 44.79 39.18 40.32 35632 1 47.19 2 39.75 3 45.75 4 53.13 5 46.26 6 54.97 35639 1 48.42 2 38.40 3 44.56 4 36.29 5 33 49 NAD NAD Rib NAD Supernumerary ( site 13 It) DV Rib Rib Supernumerary ( short 13 It) Supernumerary ( th13 full bil) DV DV NAD Rib Rib Kidney Supernumerary ( th13 full It) Supernumerary ( th13 short bil) Papilla  Size 3 ( bil) NAD DV DV VR NAD Rib Rib Rib Rib Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 short rt) Supernumerary ( th13 full rt) Supernumerary ( th13 full bil) DV DV DV DV DV DV Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) NAD DV DV Rib Rib Sternebra Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bill Retarded Ossification ( 6) Supernumerary ( th13 full bil) DV DV VR DV Rib Rib Rib Rib Supernumerary ( th13 full Supernumerary ( th13 full Supernumerary ( th13 full Supernumerary bil) bill bil) DV DV DV Rib ( th13 rt short It full Supernumerary ( th13 full bil) DV DV 174 1 2 3 4 5 6 7 8 9 10 !

Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657  1_

INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP I: o mg/ m3 DOE #/ FETUS # FETUS WT STRUCTURE 35639 ( Cont. 1 6 44.17 Rib 7 45.61 Kidney Rib 8 46.14 Rib 9 43.83 Rib 10 37.44 Rib 35644 1 46.69 2 41.19 3 41.86 Rib 4 30.58 Rib 5 48.54 6 44.33 Rib 7 44.09 Rib 8 33.15 Rib 35646 42.85 41.94 Rib 30.51 34.71 Rib 44.20 Rib 38.80 33.59 Rib 41.79 Rib 35.33 41.30 Rib 11 47.79 Rib 35656 1 42.97 Rib 2 38.32 Rib 3 36.76 Rib 4 45.17 Rib CLASSIF FINDING( S) ICATION Supernumerary ( th13 full bil) DV Papilla  Size 3 ( bil) VR Supernumerary ( th13 short bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 It short) DV NAD NAD Supernumerary ( th13 short It full rt) DV Supernumerary ( th13 short It) DV NAD Supernumerary ( th13 site It) DV Supernumerary ( th13 short bil) DV Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full It site rt) DV Supernumerary ( th13 full It) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 short bil) DV Supernumerary ( th13 short bil) DV Supernumerary ( th13 full bil) DV 175 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP I: o mg/ m3 DOE #/ CLASS1F FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35656 ( Cont.) 5 39.89 Rib 6 30.85 Rib 7 42.80 35658 1 49.07 2 30.52 Kidney Rib 3 41.33 Rib 4 41.37 Rib 5 36.96 Rib 6 47.50 Rib 7 47.94 Kidney Rib 8 46.50 Rib 9 46.85 Rib 35659 1 39.13 Rib 2 37.43 3 32.98 Rib 4 30.31 5 20.86 Rib Pelvis 6 23.25 Rib 7 30.55 Rib 8 28.87 Rib 9 38.09 Rib 10 39.74 11 38.57 12 34.34 Rib 35666 1 43.67 Rib Sternebra Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD NAD Papilla  Size 3 ( bil) VR Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Papilla  Size 3 ( bil) VR Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bill DV Supernumerary ( th13 full bill DV Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 short bil) DV NAD Supernumerary ( th13 full bil) DV Retarded Ossification ( pubis bill VR Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bill DV NAD NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 short rt full It) DV Retarded Ossification ( 6) VR 176 1 2 3 4 5 6 7 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 . Ai 1 a\ ~ 1 F"

INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP I: o mg/ m3 DOE #/ FETUS # FETUS WT. STRUCTURE 35666 ( Cont.) 2 38.55 Rib 3 39.87 Rib 4 36.78 5 37.22 Rib Sternebra 6 41.09 Sternebra 7 41.51 Sternebra 8 37.84 9 39.93 35675 1 44.94 Rib 2 43.93 Rib 3 40.43 Rib Sternebra 4 37.46 Rib 5 40.04 Rib 6 42.65 Rib 7 43.55 Rib 8 39.04 Rib 9 41.46 Rib 35677 42.03 37.91 Rib 32.42 30.55 Rib 35.51 Rib 35.69 Rib 36.50 Kidney Rib 8 37.90 9 37. a7 Rib 10 28.11 Rib 11 28.52 Rib CLASS1F FINDING( S) ICATION Supernumerary ( th13 short bil) DV Supernumerary ( th13 short It full rt) DV NAD Supernumerary ( th13 full bil) DV Retarded Ossification ( 6) VR Retarded Ossification ( 6) VR Retarded Ossification ( 6) VR NAD NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Retarded Ossification ( 6) VR Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 short bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 short bill DV Supernumerary ( site 13 It) DV Supernumerary ( th13 full bil) DV Papilla  Size 3 ( bill VR Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full It) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 short It full rt) DV 177 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP I o mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT . STRUCTURE FINDING ( S) ICATION 35677 Cont .) 12 29.21 Rib Supernumerary ( th13 full bil) DV 178 1 2 3 4 5 6 7 8 9 10 1 2 3 4 5 6 7 8 9 10 11 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 11: 30 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35573 40.83 38.34 32.89 Rib 36.27 36.64 Rib 26.84 Rib 32.62 42,18 Rib 37.93 33.96 35574 46.41 Rib 44.28 Rib 39.65 Rib 35.90 Rib 28.28 Rib 37.51 Rib 41.91 41.17 Rib 50.65 Rib 41.81 Rib 48.64 Rib 35584 1 44.40 Rib Rib Skull 2 44.40 Rib 3 40.11 Rib 4 40.03 Rib 5 44.80 6 40.47 Rib 7 33.75 Rib NAD NAD Supernumerary ( th13 full It) DV NAD Supernumerary ( th13 full rt) DV Supernumerary ( th13 short bil) DV NAD Supernumerary ( th13 full bil) DV NAD NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full bill DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 short bil) DV Supernumerary ( th13 full bil) DV Fused ( thl2 It proximal) M Retarded Ossification ( 7 It) VR Supernumerary ( th13 short bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 short rt full It) DV Supernumerary ( th13 full bil) DV 179 1 2 3 4 5 6 7 8 9 10 11 12 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 11: 30 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35585 1 45.02 Rib 2 46.90 3 42.13 Rib 4 41.19 Rib 5 45.38 Rib 6 43.97 Rib 7 45.31 Rib 8 35.31 Rib 35588 40.54 Rib 36.63 Rib 40.71 Rib 28.10 Rib 31.48 Rib 29.53 Rib 44.63 Rib 39.04 Rib 40.58 Rib 39.66 Rib 38.37 36.26 Rib 35593 1 39.93 2 42.10 Rib 3 36.59 Rib 4 33.85 5 36.85 Rib 6 35.11 Rib 7 29.79 Rib 8 31.10 Rib 9 24.23 Rib 10 36.28 Rib Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 short rt full It) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary NAD Supernumerary NAD Supernumerary ( th13 short Supernumerary NAD Supernumerary ( th13 short Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary ( th13 full bil) DV ( th13 full bil) DV ( th13 full bil) DV ( th13 full bil) DV ( th13 full bil) DV ( th13 full bil) DV ( th13 full bil) DV ( th13 full bil) DV ( th13 full bil) DV ( th13 full bil) DV ( th13 full bil) DV It full rt) DV ( th13 full bil) DV rt full It) DV ( th13 short bil) DV ( th13 full bil) DV ( th13 full bil) DV ( th13 full bil) DV ( th13 full rt) DV 180 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 I Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 11: 30 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35593 ( Cont.) Rib 11 36.24 Rib 35595 54.64 Rib 46.01 42.09 Rib 48.22 Rib 41.37 Rib 47.70 Rib 47.22 45.75 Rib 50.93 Rib 35600 1 29.76 Rib 2 44.33 Rib 3 42.28 Kidney Rib 4 38.25 Rib 5 30.92 Rib 6 37.30 Rib 7 41.03 Rib 8 40.10 Rib 9 41.93 10 43.67 Rib 11 45.27 Rib 35606 42.48 Sternebra 41.60 41.23 Rib 45.11 Rib 48.24 51.84 46.58 45.50 41.77 Fused ( th12 It proximal) M Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full It) Dv Supernumerary ( th13 full It) DV Supernumerary ( th13 full rt) DV Papilla  Size 3 ( rt) VR Supernumerary ( th13 full bil) DU Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bill DV Supernumerary ( th13 full rt) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Retarded Ossification ( 6) VR NAD Supernumerary ( th13 short bill DV Supernumerary ( th13 full rt) DV NAD NAD NAD NAD NAD 1 2 3 4 5 6 7 8 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 11: 30 mg/ m3 DOE #/ CLASS1F FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35614 1 37.30 Rib Sternebra 2 32.95 Rib Sternebra 3 36.04 Sternebra 4 33.55 5 32.83 6 34.84 Rib Sternebra 7 33.12 Rib 8 32.42 Sternebra 9 34.07 10 32.29 Sternebra 11 29.53 12 28,16 Sternebra 13 34.21 35617 46.34 Rib 38.16 Rib 36.08 Rib 28.62 28.22 27.65 41.87 Rib 31.76 Rib 35630 1 48.82 Rib 2 42.35 3 46.99 Rib 4 40.59 Rib Skull 5 44.92 Rib 6 47.94 7 45.70 Rib 8 43.31 Supernumerary ( th13 full bil) DV Retarded Ossification ( 6) VR Supernumerary ( th13 short It) DV Retarded Ossification ( 6) VR Retarded Ossification ( 6) VR NAD NAD Supernumerary ( th13 short rt full It) DV Retarded Ossification ( 6) VR Supernumerary ( th13 full bil) DV Retarded Ossification ( 6) VR NAD Retarded Ossification ( 6) VR NAD Retarded Ossification ( 6) VR NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 short: bill DV NAD NAD NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 short bil) DV Supernumerary ( th13 short bill DV NAD Supernumerary ( short 13 It) DV Supernumerary ( th13 short bil) DV Retarded Ossification ( 7 rt) VR Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full bil) DV NAD 182 1 2 3 4 5 6 7 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 11: 30 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35633 44.37 Rib 39.46 Rib 40.05 Rib 42.26 Rib 43.50 Rib 34.82 Rib 41.28 35642 40.60 36.68 Rib 37.64 30.85 36.93 29.95 33.32 43.56 39.33 Sternebra 35647 48.33 48.14 46.75 Rib 39.04 47.53 48.20 48.77 Rib 45.06 38.47 Rib 10 34.89 35649 1 51.53 Rib 2 45.85 Rib Supernumerary ( th13 full bill DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 short It) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bill DV NAD NAD Supernumerary ( th13 full bill DV NAD NAD NAD NAD NAD NAD Retarded Ossification ( 6) VR NAD NAD Supernumerary ( th13 full bill DV NAD NAD NAD Supernumerary ( site 13 It) DV NAD Supernumerary ( th13 short It full rt) DV NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 short It full rt) DV 183 1 2 3 4 5 6 7 1 2 3 4 5 6 7 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 11: 30 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35649 3 4 5 6 ( Cont.) 41.73 33.95 34.54 35.43 Rib Rib Rib Supernumerary ( th13 short Supernumerary Supernumerary NAD It full rt) ( th13 full bill ( th13 full bil) DV DV DV 7 8 9 10 11 28.63 56.82 42.10 32.76 35.18 Rib Rib Rib Rib Rib Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary ( th13 full rt) ( th13 full bil) ( th13 full bill ( th13 full bil) ( th13 full bil) DV DV DV DV DV 35667 45.48 50.41 39.90 39.23 Rib Rib Sternebra Supernumerary ( th13 full bill Supernumerary ( th13 full bil) Retarded Ossification ( 6) NAD DV DV VR 38.18 NAD 44.25 44.13 Rib Rib Supernumerary ( th13 short bil) Supernumerary DV 8 39.92 Rib Supernumerary ( th13 full bil) ( th13 short rt full It) DV DV 35669 44.42 NAD 45.46 39.91 40.10 40.89 37.38 43.31 Rib Rib Rib Rib Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) DV DV DV DV DV DV 35670 1 42.35 NAD 2 44.29 Rib Supernumerary ( TH13 full bil) DV 3 4 40.49 45.51 Sternebra Sternebra Rib Retarded Ossification ( 6) Retarded Ossification ( 6) Supernumerary ( th13 full bil) VR VR DV 184 1 2 3 4 5 6 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 11: 30 mg/ m3 DOE #/ FETUS # FETUS WT.

35670 ( Cont.) 5 43.69 6 44.03 7 42.76 8 51.30 9 45.27 35674 38.82 43.17 21.65 21.35 36.71 32.16 7 33.57 8 29.71 9 34.30 10 35.93 11 37.17 STRUCTURE Sternebra Rib Sternebra Sternebra Rib Rib Sternebra Rib Rib Rib Head Palate Snout Tongue Skull Rib Rib Rib CLASSIF FINDING( S) ICAT1ON Retarded Ossification ( 6) Supernumerary ( th13 short rt) Fused ( 3 5misaligned) Retarded Ossification ( 6) Supernumerary ( th13 full bil) Supernumerary ( th13 short It) Retarded Ossification ( 6) Supernumerary ( th13 full bil)

NAD Supernumerary ( th13 full bil) Supernumerary ( th13 full rt) NAD NAD Malformation ( micromaxilla) Cleft Malformation ( naris atresia bil) Protruding Malformation ( micromaxilla) Supernumerary ( th13 full bil) NAD Supernumerary ( th13 full bil) Supernumerary ( th13 full rt) NAD VR DV DV VR DV DV VR DV DV DV M M M N M DV DV DV 185 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 111: 100 mg/ m3 DOE #/ CLASS1F FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35580 1 2 3 4 5 6 7 8 9 34.01 33.42 36.42 32.51 31.59 43.60 43.24 37.88 39.59 Kidney Rib Rib Kidney Rib Rib Rib Rib Rib Papilla  Size Supernumerary Supernumerary Papilla  Size Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary NAD 3 ( bill th13 full bil) th13 full bil) 3 ( bill th13 full bil) th13 full bill th13 full bil) th13 full bil) th13 full bil) VR DV DV VR DV DV DV DV DV 10 37 * 54 Rib Supernumerary ( th13 full bil) DV 35582 48.73 41.08 38.80 44.13 40.97 36.04 33.30 29.29 36.01 Rib Rib Rib Rib Rib Rib Rib Rib Rib Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary Supernumerary ( th13 ( th13 ( th13 ( th13 ( th13 ( th13 ( th13 ( th13 ( th13 full bil) full bill short rt) full bil) full bil) full bil) full bil) full bil) full bill DV DV DV DV DV DV DV DV DV 35587 37.54 Rib Supernumerary ( th13 full bil) DV 31.87 NAD 7 8 9 10 21.99 33.59 26.41 32.22 39.13 37.44 35.10 37.61 Rib Rib Rib Kidney Rib Rib Rib Rib Rib Supernumerary ( th13 full bill Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Papilla  Size 3 ( bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bill Supernumerary ( th13 full bill DV DV DV VR DV DV DV DV DV 186 1 2 3 4 5 6 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 111: loo mg/ m3 DOE #/ FETUS # FETUS WT 35589 49.46 40.37 38.43 38.81 32.03 32.89 7 33.90 8 33.86 9 48.13 10 40.92 35594 1 41.76 2 38.86 3 37.92 4 40.16 5 35.48 6 32.77 7 34.55 35609 1 45.98 2 25.20 3 47.09 4 38.56 5 26.84 6 35.48 7 33.87 8 39.55 9 30.30 10 48.78 CLASSIF STRUCTURE FINDING( S) ICATION Rib Supernumerary ( th13 full bil) DV Rib Supernumerary ( th13 full bil) DV NAD Rib Supernumerary ( th13 full bil) DV Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 short rt full It) DV DV Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) DV DV NAD Rib Supernumerary ( th13 full bil) DV Rib Supernumerary ( th13 full bil) DV Rib Supernumerary ( th13 full bil) DV Rib Rib Rib Pelvis Supernumerary ( th13 ful bill Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Retarded Ossification DV DV DV Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) ( pubisbi1) VR DV DV Rib Supernumerary ( th13 short bil) NAD DV Rib Supernumerary ( th 13 short bil) DV NAD NAD Rib Rib Supernumerary ( th13 short rt) Supernumerary ( th13 full bil) NAD DV DV Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) DV DV 187 1 2 3 4 5 6 7 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 111: 100 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35610 42.75 Rib 39.73 Rib 39.85 Rib 36.16 Rib 44.21 Rib 44.81 Rib 45.38 Rib 35611 1 39.30 Rib Sternebra 2 28.07 Rib Sternebra 3 35.89 Rib 4 29.13 Sternebra 5 29.40 Sternebra 6 32.17 Sternebra 7 40.21 Sternebra 8 29.49 Rib Sternebra 9 27.93 10 33.55 Rib Sternebra 35615 1 39.60 Rib Skull 2 40.28 Rib 3 29.81 Rib 4 32.87 Rib 5 29.91 Rib 6 33.02 Sternebra 7 38.78 8 30.65 Rib 9 37.76 Rib Supernumerary ( th13 short bill DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 It full) DV Retarded Ossification ( 6) VR Supernumerary ( th13 It short) DV Retarded Ossification ( 6) VR Supernumerary ( th13 It short) DV Retarded Ossification ( 6) VR Retarded Ossification ( 6) VR Retarded Ossification ( 6) VR Retarded Ossification ( 6) VR Supernumerary ( th13 It short) DV Retarded Ossification ( 6) VR NAD Supernumerary ( th13 It short) DV Retarded Ossification ( 6) VR Supernumerary ( th13 rt) DV Retarded Ossification ( 8 bil) VR Supernumerary ( th13 full bil) DV Supernumerary ( th13 rt short It full) DV Supernumerary ( th13 It short rt full) DV Supernumerary ( th13 short bil) DV Retarded Ossification ( 6) VR NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV 188 1 2 3 4 5 6 7 1 2 3 4 5 6 7 8 9 10 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 h f ^#' XI.* I INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 111: 100 mq/ m3 DOE #/ FETUS # FETUS WT.

35615 ( Cont.)

10 30.59 11 38.92 35622 1 51.40 2 51.88 3 47.94 4 44.60 5 47.36 35624 39.45 38.37 33.55 35.93 31.75 37.17 37.92 8 36.03 9 33.99 10 33.96 35627 45.39 42.90 36.70 32.36 43.67 31.69 37.50 29.72 30.14 28.77 STRUCTURE Sternebra Sternebra Rib Rib Rib Rib Kidney Rib Rib Rib Rib Rib Rib Rib Subcutis Rib Rib Rib Subcutis Rib CLASSIF FINDING( S) ICATION Retarded Ossification ( 6) Retarded Ossification ( 6) NAD Supernumerary ( th13 full bill Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Papilla  Size 3 ( bill Supernumerary ( th13 short bil)

Supernumerary ( th13 full bil) Supernumerary ( th13 full bill Supernumerary ( th13 full bill Supernumerary ( th13 full bill Supernumerary ( th13 full bill Supernumerary ( th13 full bil) Hemorrhage ( snout * 1 Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Hemorrhage ( head *) Supernumerary ( th13 full bil)

NAD NAD NAD NAD NAD NAD NAD NAD NAD NAD VR VR DV DV DV DV VR DV DV DV DV DV DV DV N DV DV DV N DV 189 1 2 3 4 5 6 7 8 9 10 1 2 3 4 5 6 7 1 2 3 4 5 6 7 8 9 10 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 111: 100 mg/ m3 DOE #/ FETUS # FETUS WT.

35634 42.03 43.91 38.72 40.09 29.90 43.29 49.08 48.64 36.34 28.97 35641 40.89 32.44 35.82 29.50 32.00 22.36 26.40 8 24.12 9 41.81 10 41.74 11 44.80 35643 39.82 49.52 45.01 39.67 44.21 42.55 41.07 51.13 45.16 52.15 CLASSIF STRUCTURE FINDING( S) ICATION Rib Rib Sternebra Supernumerary ( th13 full It) Supernumerary ( th13 full bil) Retarded Ossification ( 6) DV DV VR NAD NAD Sternebra Skull Kidney Sternebra Retarded Ossification Retarded Ossification Papilla  Size 3 ( bil) Retarded Ossification NAD 6) 13 It)

6) VR VR VR VR NAD Rib Rib Supernumerary ( full 13 bil) Supernumerary ( full 13 bil) NAD DV DV Rib Supernumerary ( short 13 It) DV NAD Rib Supernumerary NAD ( th13 short rt full It) DV NAD NAD NAD Rib Rib Rib Rib Rib Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bill NAD DV DV DV DV DV DV DV Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) DV DV 190 1 2 3 4 5 6 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 111: 100 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( s) ICATION 35645 1 39.81 Rib 2 38.11 Rib Sternebra 3 31.85 Rib 4 34.82 Rib 5 35.37 Rib 6 37.95 Rib 7 35.43 8 37.46 Rib 9 32.40 10 37.58 35652 1 47.75 Rib 2 43,95 3 38.44 4 36.79 Rib 5 46.34 Rib 6 46.24 Rib 7 41.90 8 46.21 Rib 9 42.43 Rib 35660 1 48.07 Rib 2 51.62 Rib 3 46.11 Rib 35661 51.89 43.55 35.22 42.12 36.14 24.88 Supernumerary ( th13 short rt) Supernumerary ( th13 full bil) Retarded Ossification ( 6) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) NAD Supernumerary ( th13 full rt) NAD NAD Supernumerary ( th13 full bil) NAD NAD Supernumerary ( th13 site It) Supernumerary ( th13 short rt site It) Supernumerary ( th13 short rt full It) NAD Supernumerary ( th13 full bil) Supernumerary ( th13 full bil)

Supernumerary ( th13 full bil) Supernumerary ( th13 rt short It full) Supernumerary ( th13 full bil)

NAD NAD NAD NAD NAD NAD DV DV VR DV DV DV DV DV DV DV DV DV DV DV DV DV DV 191 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP 111: 100 mg/ m3 DOE #/ CLASS IF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35661 ( Cont.) 7 40.66 8 41.22 9 46.72 10 44.65 11 38.21 35662 1 43.41 2 44.62 3 36.94 4 31.76 5 45.71 6 38.28 7 39.06 8 38.43 9 25.75 10 31.24 11 23.39 Rib Kidney Rib Rib Rib Rib Rib Rib Rib Rib Rib NAD NAD NAD Supernumerary ( th13 short bil) NAD Papilla  Size 3 ( bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 short rt full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 short It) NAD NAD Supernumerary ( th13 short rt full It) Supernumerary ( th13 full bil) DV VR DV DV DV DV DV DV DV DV DV 192 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP IV: 300 mg/ m3 DOE #/ FETUS # FETUS WT.

35571 1 45 76 2 47.34 3 42.94 4 47.61 5 49.05 6 47.21 7 48.67 8 45.39 9 45.28 10 45.93 35577 1 40.07 2 34.80 3 39.24 4 35.32 5 39.01 6 38.75 7 38.61 8 35.41 9 37.30 35583 1 40.04 2 40.44 3 48.24 4 32.64 5 44.54 6 49.34 CLASSIF STRUCTURE FINDING( S) ICATION Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) DV DV NAD NAD Rib Supernumerary ( th13 short It full rt) DV Rib Rib Supernumerary Supernumerary th13 full bil) th13 full bill DV DV Rib Rib Supernumerary Supernumerary th13 full bil) th13 full bil) DV DV Rib Supernumerary th13 full It) DV NAD Rib Supernumerary ( th13 full bill DV Rib Supernumerary ( th13 short It full rt) DV Rib Rib Rib Supernumerary ( th13 full Supernumerary ( th13 full Supernumerary ( th13 site rt full It) NAD DV DV DV NAD Rib Supernumerary ( th13 full DV Kidney Small Papilla  Size 2 ( bilateral) VR Rib Sternebra Supernumerary ( th13 full Fused ( 4 5) DV DV Rib Supernumerary ( th13 full DV Sternebra Rib Retarded Ossification,( 6 Supernumerary ( th13 full VR DV Rib Rib Sternebra Supernumerary ( th13 full Supernumerary ( th13 full Retarded Ossification ( 6 DV DV VR Rib Supernumerary ( th13 full DV 193 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP IV: 300 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35583 7 8 ( Cont.) 48.43 45.29 Rib Sternebra Rib Supernumerary ( th13 It short rt full) Retarded Ossification ( 6) Supernumerary ( th13 full bil) DV VR DV 35586 49.09 NAD 41.79 NAD 34.84 NAD 37.38 NAD 30.20 NAD 35.16 NAD 46.32 NAD 39.73 NAD 10 38.06 30.17 Rib Skull Supernumerary ( th13 short It full, rt) Retarded Ossification ( 7 It) DV VR 35591 43.40 41.38 36.46 Rib Rib Supernumerary ( th13 full It) Supernumerary ( th13 full bil) NAD DV DV 33.97 29.91 25.83 31.87 Rib Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) NAD DV DV DV 32.78 43.07 Rib Rib Supernumerary ( th13 full It) Supernumerary DV 10 11 42.71 34.42 Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full It site rt) DV DV 12 32.59 Rib Supernumerary ( th13 full bil) ( th13 full It site rt) DV DV 35592 1 2 53.59 38.62 Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) DV DV 194 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 1 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP IV: 300 mg/ m3 DOE #/ FETUS # FETUS WT. STRUCTURE 35592 ( Cont.) 3 47.86 Rib 4 48.41 Rib 5 47.84 Rib 6 45.53 Rib 7 39.53 Rib 8 42.27 9 40.05 Rib 10 37.56 11 45.04 Rib 35607 1 47.67 Rib 2 45.22 Rib 3 43.67 Rib 4 42.35 Rib 5 37.79 Rib Sternebra 6 49.38 Rib 7 46.19 Rib 8 40.70 Rib 9 40.16 10 36.07 Rib 11 29.88 Rib 12 33.49 Rib 13 33.23 Rib 35608 1 42.23 Sternebra 2 36.76 Rib 3 34.37 Rib 4 36.56 Rib 5 34.51 Rib 6 31.11 Rib 7 40.06 Rib CLASSIF FINDING( S)

Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bill Supernumerary ( th13 full bil) NAD Supernumerary ( th13 full bil) NAD Supernumerary ( th13 full bill Supernumerary ( th13 full bill Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bill Retarded Ossification ( 6) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bill NAD Supernumerary ( th13 full bill Supernumerary ( th13 short It full , rt) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil)

Retarded Ossification ( 6) Supernumerary ( th13 full bill Supernumerary ( th13 full bill Supernumerary ( th13 rt short) Supernumerary ( th13 full It short rt) Supernumerary ( th13 full bil) Supernumerary ( th13 full bill ICATION DV DV DV DV DV DV DV DV DV DV DV DV VR DV DV DV DV DV DV DV VR DV DV DV DV DV DV 195 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP IV: 300 mg/ m3 DOE #/ CLASS1F FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35608 ( Cont.) 8 32.58 Rib 9 38.12 Rib 10 36.89 11 25.30 12 27.01 Rib 35618 1 59.51 Rib 2 51.47 Rib 3 41.21 4 52.26 5 45.90 Rib 35620 35.80 44.27 34.07 Rib 32.40 28.00 31.36 44.61 46.24 41.40 Rib 35625 49.94 49.48 43.54 Rib 41.04 43.28 Rib 46.67 Kidney 46.02 35626 1 39.07 2 35.40 3 38.53 Supernumerary ( th13 short rt full It) DV Supernumerary ( th13 full bil) DV NAD NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full It) DV NAD NAD Supernumerary ( th13 short It) DV NAD NAD Supernumerary ( th13 short bil) DV NAD NAD NAD NAD NAD Supernumerary ( th13 short bil) DV NAD NAD Supernumerary ( th13 short bil) DV NAD Supernumerary ( th13 short bil) DV Papilla  Size 3 ( bil) VR NAD NAD NAD NAD 196 1 2 3 4 5 6 7 8 9 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 I"

INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS

GROUP IV: 300 mg/ m3 DOE #/ CLASS1F FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35626 ( Cont.) 4 38.37 5 37.25 6 37.30 Rib Sternebra 7 40.55 8 35.11 Rib 9 35.01 35631 46.69 45.34 44.55 Rib 42.24 Rib 43.99 Rib 40.31 Rib 46.06 Rib 37.64 41.37 Skull 35635 1 40.23 Rib Sternebra 2 36.16 Rib 3 36.35 Rib Sternebra 4 42.78 Rib Sternebra 5 40.03 6 42.21 Rib Sternebra 7 38.72 8 38.74 Rib Sternebra NAD NAD Supernumerary ( th13 full bil) DV Retarded Ossification ( 6) VR NAD Supernumerary ( th13 short rt) DV NAD NAD NAD supernumerary ( th13 short bil) DV Subernumerar; ( th13 short rt) Supernumerary ( th13 short rt) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) NAD Retarded Ossification ( hyoid bent bil)

Supernumerary ( th13 short It full rt) Retarded Ossification ( 6) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Retarded Ossification ( 6) Supernumerary ( th13 short It full rt) Retarded Ossification ( 6) NAD Supernumerary ( th13 full It short rt) Retarded Ossification ( 6) NAD Supernumerary ( th13 full bil) Retarded Ossification ( 6) DV DV nv DV VR DV VR DV DV VR DV VR DV VR DV VR 1 2 3 4 5 6 7 1 2 3 4 5 6 7 8 9 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP IV: 300 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35635 ( Cont.) 9 42.98 Sternebra Retarded Ossification ( 6) VR 35637 1 2 45.54 37.90 Rib Rib Supernumerary ( th13 full bil) Supernumerary DV 3 42.40 NAD ( th13 short rt full It) DV 4 48.23 NAD 5 6 7 8 9 40.94 33.80 41.21 35.76 43.07 Rib Rib Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) NAD DV DV DV DV 35640 51.24 NAD 51.20 NAD 46.24 40.00 45.75 Rib Rib Supernumerary ( th13 short bill Supernumerary ( th13 full bil) NAD DV DV 46.28 48.84 Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) DV DV 35650 50.88 48.61 46.88 47.16 43.33 Rib Rib Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) NAD DV DV DV DV 43.81 32.98 Rib Supernumerary ( th13 full bil) NAD DV 40.83 48.48 Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) DV DV 35653 1 2 27.44 40.24 Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) DV DV 198 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 Dimethyl Glutarate ( DMG): Inhalation DevelopmentalToxicity Study in Rabbits DuPont 10657 i ** * " I iy INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP IV: 300 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35653 3 4 ( Cont.) 46.15 31.43 Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) DV DV 5a 37.27 NAD ga 7 29.70 34.97 NAD NAD 8 42.88 Rib Supernumerary ( th13 full bil) DV 9 39.98 NAD 10 41.17 Rib Supernumerary ( th13 full bil) DV 11 41.35 Rib Supernumerary ( th13 full bil) DV 12 31.50 Rib Supernumerary ( th13 full bil) DV 13 25.42 Rib Supernumerary ( th13 full bill DV Pelvis Retarded Ossification ( pubis bil) VR 35663 46.68 Rib Supernumerary ( thl3 short It) DV 39.50 NAD 39.09 Rib Supernumerary ( th13 short It) DV 33.60 NAD 41.70 NAD 42.98 NAD 38.55 NAD 43.40 NAD 38.11 NAD 35672 35.57 NAD 33.70 Rib Supernumerary ( th13 full bil) DV 32.98 NAD 30.59 NAD 28.48 Rib Supernumerary ( th13 full bil) DV 33.31 Rib Supernumerary ( th13 full bil) DV 33.45 36.12 26.81 Rib Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 short rt) Supernumerary ( th13 full bil) DV DV DV a No skeletal examination; fetus was inadvertently disarticulated during skeletal processing.

199 1 2 3 4 5 6 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP IV: 300 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING ( S) ICATION 35676 45.31 Rib 44.66 40.60 Rib 44.75 Rib 40.47 Rib 43.40 Rib Supernumerary ( th13 full bil) DV NAD Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bill DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bil) DV 200 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP v: 1000 mg/ m3 DOE #/ FETUS # FETUS WT.

35569 1 41.72 2 35.67 3 41.32 4 33.22 5 32.95 6 39.33 7 35.02 8 37.26 35581 1 40.20 2 29.85 3 35.57 4 32.47 5 35.74 6 31.87 7 42.79 8 39.69 9 37.33 35598 1 39.02 2 34.98 3 36.33 4 36.05 5 41.71 STRUCTURE Rib Rib Sternebra Sternebra Sternebra Sternebra Rib Rib Sternebra Rib Vertebra Heart &/ or Greater Ves sels Heart &/ or Greater Vesse1s Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib CLASSIF FINDING( SI ICATION Supernumerary ( th13 full bil) DV Supernumerary ( th13 full bill DV Retarded Ossification ( 6) VR Retarded Ossification ( 6) VR Retarded Ossification ( 6) VR Retarded Ossification ( 6) VR Supernumerary ( th13 short rt full It) DV Supernumerary ( th13 full It) DV Retarded Ossification ( 6) VR Supernumerary ( th13 full bil) DV Hemi ( th6,8) M Misshapen Heart M Septal Defect ( double outlet) M Supernumerary ( th13 full bill DV Supernumerary ( th13 full bill DV Supernumerary ( th13 full It) DV Supernumerary ( th13 full bil) DV Supernumerary ( th13 short It full rt) DV Supernumerary ( th13 short bil) DV Supernumerary ( th13 short It full rt) DV Supernumerary ( th13 full bill DV Supernumerary ( th13 short rt) DV NAD Supernumerary ( th13 full bil) DV NAD NAD NAD 201 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTEmTIONS GROUP v: 1000 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35598 ( Cont.) 6 30.95 7 37.90 8 39.64 35602 1 33.98 2 31.12 3 32.60 4 35.50 5 34.33 6 32.22 7 28.60 8 27.36 9 29.05 35605 1 49.44 2 43.75 3 41.13 4 50.66 5 48.01 6 47.03 35613 1 38.93 2 29.09 Rib Rib Rib Rib Pelvis Rib Rib Rib Pelvis Rib Pelvis Rib Pelvis Rib Sternebra Rib Rib Rib Rib Rib Rib Rib NAD NAD NAD Supernumerary th13 full bil) Supernumerary th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 short rt full It) Retarded Ossification ( pubis bil) Supernumerary ( th13 short rt full It) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Retarded Ossification ( pubis bil) Supernumerary ( th13 full bil) Retarded Ossification ( pubis bi1) Supernumerary ( th13 full bil) Retarded Ossification ( pubisbi1)

Supernumerary ( th13 full bil) Retarded Ossification ( 6) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil)

Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) DV DV DV DV VR DV DV DV VR DV VR DV VR DV VR DV DV DV DV DV DV DV 202 1 2 3 4 5 6 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP v: 1000 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35613 ( Cont.) Pelvis Retarded Ossification 3 4 5 6 7 28.97 29.25 34.63 29.38 25.86 Rib Rib Kidney Rib Sternebra Rib Sternebra Rib Sternebra Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Papilla  Size 3 ( bill Supernumerary ( th13 full bil) Retarded Ossification ( 6) Supernumerary ( th13 full bill Retarded Ossification ( 6) Supernumerary ( th13 full bil) Fused ( 4 5) ( pubisbil) VR DV DV VR DV VR DV VR DV DV 8 25.03 Sternebra Rib Pelvis Retarded Ossification ( 6) Supernumerary ( th13 full bil) Retarded Ossification VR DV 9 29.09 Rib Supernumerary ( th13 full bil) ( pubis bi1) VR DV 35619 35.33 42.02 Sternebra Retarded Ossification ( 6) NAD VR 38.75 NAD 39 41 NAD 39.36 25.53 Sternebra Sternebra Pelvis Retarded Ossification ( 6) Fused ( 5 6) Retarded Ossification VR DV Skull Retarded Ossification ( pubis bi1) VR 7 8 39.78 45.62 Sternebra Sternebra Retarded Ossification ( 6) Retarded Ossification ( 6) ( 1; 2 3,6 8bil) VR VR VR 9 10 11 36.45 36.30 42.64 Sternebra Sternebra Retarded Ossification ( 6) Retarded Ossification,( 6) NAD VR VR 35623 1 44.30 Rib Sternebra Supernumerary ( th13 short It) Retarded Ossification ( 6) DV VR 203 1 2 3 4 5 6 7 8 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP v: 1000 mg/ m3 DOE #/ FETUS # FETUS WT.

35623 ( Cont.) 2 43.99 3 44.36 4 38.17 35629 44.53 37.97 41.09 34.40 28.18 34.37 37.96 33.44 35636 1 52.37 35638 1 41.89 2 37.86 31.44 35.93 31.57 38.34 32.17 38.04 35.21 35648 1 39.79 2 39.28 STRUCTURE Rib Sternebra Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib Rib CLASS1F FINDING( S) ICATION Supernumerary ( th13 short rt full It) Retarded Ossification ( 6) NAD Supernumerary ( th13 short rt full It)

Supernumerary ( th13 full bil) NAD NAD Supernumerary ( th13 full bil) NAD NAD Supernumerary ( th13 full bil) Supernumerary ( th13 full bill Supernumerary ( th13 short It full rt)

Supernumerary ( th13 full bil) Supernumerary ( th13 short rt full It) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bill Supernumerary ( th13 full bil) Supernumerary ( th13 full bill Supernumerary ( th13 full bill Supernumerary ( th13 full bil)

Supernumerary ( th13 full It) Supernumerary ( th13 full bil) DV VR DV DV DV DV DV DV DV DV DV DV DV DV DV DV DV DV DV 204 1 2 3 4 5 6 7 8 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP v: 1000 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICATION 35648 3 4 5 6 7 ( Cont.) 36.70 45.69 40.27 31.44 42.08 Rib Rib Rib Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) DV DV DV DV DV 35651 1 47.88 Rib Sternebra Supernumerary ( th13 full bil) Retarded Ossification ( 6) DV VR 2 55.33 Rib Supernumerary ( th13 full bill DV 3 49.96 Sternebra Rib Sternebra Retarded Ossification ( 6) Supernumerary ( th13 full bil) Retarded Ossification ( 6) VR DV VR 35655 41.42 44.89 Rib Supernumerary ( th13 short rt) NAD DV 39.90 NAD 45.91 49.28 46.02 Rib Rib Supernumerary ( site 13 It) Supernumerary ( th13 full bil) NAD DV DV 40.59 NAD 38.43 NAD 35664 1 37.91 NAD 2 3 41.05 39.65 Rib Supernumerary NAD ( th13 short rt full It) DV 4 41.34 NAD 5 6 7 37.93 39.13 36.40 Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) NAD DV DV 8 9 32.16 36.55 Rib Supernumerary ( th13 site It) NAD DV 205 Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP v: 1000 mg/ m3 DOE #/ FETUS # FETUS WT. STRUCTURE FINDING( S) CLASSIF ICATION 35665 1 2 3 4 5 42.26 40.39 39.25 39.08 38.69 Rib Rib Rib Sternebra Rib Rib Supernumerary ( th13 full bil) Supernumerary ( th13 short bil) Supernumerary ( th13 full bil) Retarded Ossification ( 6) Supernumerary ( th13 full bil) Supernumerary DV DV DV VR DV 6 7 8 9 35.84 36.98 30.84 37.37 Sternebra Rib Sternebra Rib Rib Rib Skull ( th13 short rt full It) Retarded Ossification ( 6) Supernumerary ( th13 short It) Retarded Ossification ( 6) Supernumerary ( th13 short bil) Supernumerary ( th13 short rt) Supernumerary ( th13 full bil) Retarded Ossification DV VR DV VR DV DV DV Sternebra Retarded Ossification ( 6) ( 1,12; 2 bill VR VR 35668 1 2 47.47 39.63 Rib Rib Sternebra Supernumerary ( th13 short bill Supernumerary ( th13 short rt) Retarded Ossification ( 6) DV DV VR 38.71 34.86 Rib Supernumerary ( 13 full bill NAD DV 40.86 35.82 Rib Rib Vertebra Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Retarded Ossification DV DV 7 8 9 10 11 12 37.32 39.37 38.54 32.92 31.84 29.07 Rib Rib Rib Rib Sternebra Rib Sternebra Rib Sternebra supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Supernumerary ( th13 full bil) Retarded Ossification ( 6) Supernumerary ( th13 rt short It full) Retarded Ossification ( 6) Supernumerary ( th13 full bil) Retarded Ossification ( 6) ( cen ce7) VR DV DV DV DV VR DV VR DV VR Dimethyl Glutarate ( DMG): Inhalation Developmental Toxicity Study in Rabbits DuPont 10657 INDIVIDUAL FETAL WEIGHTS AND ALTERATIONS GROUP v: 1000 mg/ m3 DOE #/ CLASSIF FETUS # FETUS WT. STRUCTURE FINDING( S) ICAT1ON 35673 1 41.77 Rib Supernumerary ( th13 full bill DV 2 58.02 Rib Supernumerary ( th13 full bil) DV 3 50.22 Rib Supernumerary ( th13 full bil) DV 207


[Federal Register Volume 75, Number 245 (Wednesday, December 22, 2010)]
[Rules and Regulations]
[Pages 80293-80294]
[FR Doc No: 2010-31964]

=======================================================================
-----------------------------------------------------------------------

DEPARTMENT OF TRANSPORTATION

Federal Aviation Administration

14 CFR Part 39

[Docket No. FAA-2010-0611; Directorate Identifier 2009-SW-18-AD;
Amendment 39-16487; AD 2010-22-08]
RIN 2120-AA64

Airworthiness Directives; Eurocopter France Model AS 350 B, BA,
B1, B2, B3, and D, and Model AS355 E, F, F1, F2, and N Helicopters

AGENCY: Federal Aviation Administration (FAA), Department of
Transportation (DOT).

ACTION: Final rule; correction.

-----------------------------------------------------------------------

SUMMARY: The FAA is correcting an airworthiness directive (AD) that was
published in the Federal Register. That AD applies to the specified
model helicopters. Table 1 of the AD has two part numbers that do not
contain the ``SC'' prefix. This document adds the prefix and corrects
that error. In all other respects, the original document remains the
same.

DATES: This final rule is effective December 22, 2010. The effective
date for AD 2010-22-08 remains November 26, 2010.

ADDRESSES: You may examine the AD docket on the Internet at http://www.regulations.gov; or in person at the Docket Management Facility
between 9 a.m. and 5 p.m., Monday through Friday, except Federal
holidays. The AD docket contains this AD, the regulatory evaluation,
any comments received, and other information. The address for the
Docket Office (phone:<PHONE_NUMBER>) is Document Management Facility,
U.S. Department of Transportation, Docket Operations, M-30, West
Building Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE.,
Washington, DC 20590.

FOR FURTHER INFORMATION CONTACT: DOT/FAA Southwest Region, Matt
Wilbanks, ASW-111, Aviation Safety Engineer, Rotorcraft Directorate,
Regulations and Policy Group, 2601 Meacham Blvd., Fort Worth, Texas
76137, telephone<PHONE_NUMBER>, fax<PHONE_NUMBER>.

SUPPLEMENTARY INFORMATION: This AD, Amendment 39-16487 (75 FR 65222,
October 22, 2010), requires replacing all servo-controls that are
identified in the Applicability section, Table 1, of the AD.
    As published, two part numbers shown in Table 1 on Federal Register
page 65224, under item 2. of PART 39--AIRWORTHINESS DIRECTIVES section,
are incorrect. The first incorrect part number (P/N) is ``5084;'' the
correct P/N is ``SC5084.'' The second incorrect P/N is ``5084-1;'' the
correct P/N is ``SC5084-1.'' The other P/Ns shown in Table 1 remain
unchanged.
    No other part of the preamble or regulatory information has been
changed; therefore, only Table 1 of the final rule is being published
in the Federal Register.
    The effective date of this AD is November 26, 2010.

Correction of Regulatory Text

Sec.  39.13  [Corrected]

0
In the Federal Register document 2010-26565, filed October 21, 2010 and
published on October 22, 2010 (75 FR 65222), on pages 65223 and 65224,
Table 1 containing the part numbers 5084 and 5084-1 without the correct
prefix ``SC'' is corrected to read as follows:

                                 Table 1
------------------------------------------------------------------------
           Component              Part No. (P/N)      Serial No. (S/N)
------------------------------------------------------------------------
Main rotor servo-control......  P/N SC5083.......  S/N 270M, 272M, 409M,
                                                    423M, 452M, or 1573.
                                P/N SC5083-1.....  S/N 2902 through
                                                    2921, inclusive.
                                P/N SC5084.......  S/N 30, 84, 104, 186,
                                                    438, 575, or 695.
                                P/N SC5084-1.....  S/N 1462 through
                                                    1481, inclusive.
Tail rotor servo-control......  P/N SC5072.......  S/N 222M, 306M, or
                                                    309.
------------------------------------------------------------------------

    Issued in Fort Worth, Texas, on December 10, 2010.
Lance T. Gant,
Acting Manager, Rotorcraft Directorate, Aircraft Certification Service.
[FR Doc. 2010-31964 Filed 12-21-10; 8:45 am]
BILLING CODE 4910-13-P


[Federal Register Volume 86, Number 87 (Friday, May 7, 2021)]
[Notices]
[Pages 24610-24611]
[FR Doc No: 2021-09722]

-----------------------------------------------------------------------

DEPARTMENT OF ENERGY

Federal Energy Regulatory Commission

[Docket No. AD21-10-000]

Modernizing Electricity Market Design; Supplemental Notice of
Technical Conference on Resource Adequacy in the Evolving Electricity
Sector: ISO New England Inc.

    As first announced in the Notice of Technical Conference issued in
this proceeding on April 22, 2021, the Federal Energy Regulatory
Commission (Commission) will convene a Commissioner-led technical
conference in the above-referenced proceeding on May 25, 2021, from
approximately 9:00 a.m. to 4:15 p.m. Eastern time. The conference will
be held remotely. Attached to this Supplemental Notice is an agenda for
the technical conference. Commissioners may attend and participate in
the technical conference.
    Discussions at the conference may involve issues raised in
proceedings that are currently pending before the

Commission. These proceedings include, but are not limited to:

----------------------------------------------------------------------------------------------------------------
                                                                          Docket Nos.
----------------------------------------------------------------------------------------------------------------
ISO New England Inc.........................  ER21-787-000.
ISO New England Inc.........................  ER21-943-000.
New England Power Generators Ass'n, Inc. v.   EL21-26-000.
 ISO New England Inc.
ISO New England Inc.........................  ER21-1226-000.
ISO New England Inc., New England Power Pool  ER21-1637-000.
 Participants Committee.
Independent Market Monitor for PJM v. PJM     EL19-47-000.
 Interconnection, L.L.C., Docket No.
Office of the People's Counsel for D.C. et    EL19-63-000.
 al. v. PJM Interconnection.
PJM Interconnection, L.L.C..................  EL19-100-000.
PJM Interconnection, L.L.C..................  ER21-278-000 and ER21-278-001.
New York Independent System Operator, Inc...  ER20-1718-002.
New York State Public Service Commission, et  EL16-92-004 and ER17-996-004.
 al. v. New York Independent System
 Operator, Inc.
New York Independent System Operator, Inc...  ER16-1404-005, ER16-1404-006, and ER16-1404-007.
New York Independent System Operator, Inc...  ER21-502-000 and ER21-502-001.
New York Independent System Operator, Inc...  ER21-1018-000.
Cricket Valley Energy Center LLC and Empire   EL21-7-000.
 Generating Company, LLC v. New York
 Independent System Operator, Inc.
----------------------------------------------------------------------------------------------------------------

    The conference will be open for the public to attend remotely.
There is no fee for attendance. Information on this technical
conference, including a link to the webcast, will be posted on the
conference's event page on the Commission's website (https://www.ferc.gov/news-events/events/technical-conference-regarding-wholesale-markets-administered-iso-new-england) prior to the event.
    The conference will be transcribed. Transcripts will be available
for a fee from Ace Reporting at<PHONE_NUMBER>.
    Commission conferences are accessible under section 508 of the
Rehabilitation Act of 1973. For accessibility accommodations, please
send an email to<EMAIL_ADDRESS>or call toll free (866) 208-
3372 (voice) or<PHONE_NUMBER> (TTY), or send a fax to<PHONE_NUMBER>
with the required accommodations. This notice is issued and published
in accordance with 18 CFR 2.1.
    For more information about this technical conference, please
contact David Rosner at<EMAIL_ADDRESS>or<PHONE_NUMBER> or Emma
Nicholson at<EMAIL_ADDRESS>or<PHONE_NUMBER>. For legal
exception occurred on : 2021-09722.htm
exception occurred on : 2021-09722.htm
information, please contact Meghan O'Brien at meghan.o'[email protected]
or<PHONE_NUMBER>. For information related to logistics, please contact
Sarah McKinley at<EMAIL_ADDRESS>or<PHONE_NUMBER>.

    Dated: May 3, 2021.
Kimberly D. Bose,
Secretary.
[FR Doc. 2021-09722 Filed 5-6-21; 8:45 am]
BILLING CODE 6717-01-P