Page 1of 63 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D. C. 20460 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES MEMORANDUM Date: 7/ 31/ 06 Subject: Propiconazole. Petitions for Tolerances on Field, Vegetable and Fruit Crops. Summary of Analytical Chemistry and Residue Data. Petition Numbers: 2F6371, 6E4788, 7E4860, and 8E4931.

DP Numbers: D238458, 238468, 238583, 238597, 238598, 247313, 312277, 313199, 313201 Decision Nos.:

PC Code: 122101 MRID( s): 43640401, 43655612, 43655613, 44338101, 44416501, 44548402, 44757207, 44757208, 44757210, 45080807, 45080809, 45080810, 45080811, 45215806, 45275801, 45542401, 45778901, 46473001, 46576302 40 CFR 180.434 Chemical Class: Triazole Type Fungicide From: Yan Donovan, Chemist Reregistration Action Branch 4 Health Effects Division ( 7509P)

Through: Jerry Stokes, Chemist Reregistration Action Branch 4 Health Effects Division ( 7509P)

Susan Hummel and Richard Loranger, Senior Scientists Reregistration Action Branch 4 Health Effects Division ( 7509P)

To: Mary Waller/ Cynthia Giles Parker Fungicide Branch Registration Division Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 2 of 63 This document was originally prepared under contract by Dynamac Corporation ( 1910 Sedwick Rd., Building 100, Suite B; Durham, NC 27713; submitted 7/ 14/ 2006). The document has been reviewed by the HED and revised to reflect current OPP policies. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 3 of 63 Executive Summary Propiconazole is a triazole type fungicide ( Group 3) that provides broad spectrum disease control on a variety of crops. Tolerances in/ on plant and animal commodities are currently established for the combined residues of propiconazole, 1[[ 2( 2,4 dichlorophenyl) 4 propyl 1,3 dioxolan 2 yl] methyl] 1H 1,2,4 triazole, and its metabolites determined as 2,4 dichlorobenzoic acid ( 2,4 DCBA) and expressed as parent [ 40 CFR § 180.434]. Tolerances on plant commodities range from 0.1 ppm on several commodities to 40 ppm in/ on grass hay and straw, and tolerances on animal commodities range from 0.05 ppm in milk to 2.0 ppm in liver and kidney of livestock.

Syngenta Crop Protection ( Syngenta) and Interregional Research Project No. 4 ( IR 4) have submitted several petitions supporting new or amended uses on various crops for propiconazole, formulated as a 3.6 lb/ gal emulsifiable concentrate ( EC) or a 45% wettable powder ( WP). The proposed uses are for broadcast foliar applications using ground or aerial equipment at rates ranging from 0.11 to 0.28 lb ai/ A/ application. For tree nuts, the proposed use is for up to four foliar applications at 0.225 lb ai/ A, for a total of 0.90 lb ai/ A, with a 60 day preharvest interval ( PHI). For bush and cane berries and cranberries, the proposed uses are for 4 or 5 foliar applications at 0.17 lb ai/ A, for totals of 0.68 0.84 lb ai/ A, with PHIs of 30 or 45 days. For carrots, leaf petiole vegetables, dry peas and beans, sugar beets and strawberries, the proposed uses are for 3 or 4 broadcast foliar applications at 0.11 lb ai/ A, for totals of 0.34 or 0.45 lb ai/ A, with PHIs of 0 to 21 days. For mint, the proposed use is for two broadcast foliar applications at 0.113 lb ai/ A, for a total of 0.225 ai/ A, with a PHI of 30 days. For soybeans, the proposed use is for two broadcast foliar applications at 0.169 lb ai/ A at up to growth stage R6, for a total of 0.338 ai/ A, with a PHI of 30 days. For rice, the proposed use is for a single application or split applications at heading totaling ~ 0.30 lb ai/ A, with a PHI of 35 days. For other cereal grains, the proposed uses are for 2 to 4 broadcast foliar applications at 0.113 lb ai/ A up to heading or grain development, for totals of 0.22 or 0.45 ai/ A, with PHIs of 14 45 days. In conjunction with these uses, Syngenta and IR 4 are proposing permanent tolerances for propiconazole residues in/ on various plant commodities at levels ranging from 0.1 ppm on alfalfa to 32 ppm on soybean hay.

The nature of propiconazole residues in plants and animals is adequately understood based on the available peanut, wheat, grape, rice, celery, carrot, goat, and poultry metabolism studies. A major metabolic pathway in plants appears to be hydroxylation ( primarily of the beta carbon) of the n propyl group on the dioxolane ring of the cis/ trans isomers of propiconazole. These metabolites appear to readily form sugar conjugates. The majority of TRR was found in the stalks, such as peanut stalk, wheat forage and straw, grape leaves, and celery stalks. The HED MARC concluded that for plants and animals, residues of propiconazole and all its metabolites containing the 2,4 dichlorophenyl moiety ( 2,4 DCBA), including conjugates, are of concern and should be included in the dietary ( food) risk assessments, and that propiconazole per se should be included in the dietary ( water) risk assessments. For tolerance expression, MARC concluded that the current tolerance expression for propiconazole should be amended to include residues of propiconazole per se only. This allows for harmonization with the residue definition for Codex.

The free triazole, triazole alanine, and triazole acetic acid are also residues of concern. Since these are common metabolites from several triazole containing pesticides, the risk assessment for Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 4 of 63 triazoles has been assessed separately ( HED memo of 2/ 7/ 06, M. Doherty, D322215). The cited assessment included all the proposed propiconazole new uses in the subject petitions.

For enforcing the revised tolerances, a GC method using flame ionization detection ( Method AG 354) is also available for determining residues of propiconazole per se in/ on plant commodities, and has an LOQ of 0.05 ppm. In addition, Multiresidue Methods Section 302 can also be used to determine parent propiconazole in both plant and animal matrices.

Samples from the various field trials and processing studies supporting the current petitions were analyzed for combined residues of propiconazole and its 2,4 DCBA containing metabolites using GC/ ECD Methods AG 454B and AG 626, which are more recent versions of AG 454A. With the exception of almond hulls, which had a LOQ of 0.1 ppm, the validated LOQ for combined residues was 0.05 ppm in all raw and processed commodities. Each of the methods was validated in conjunction with the field trials and processing studies. In addition, samples from one of the wheat field trials and processing studies were also analyzed for residues of propiconazole, per se, using a multiresidue method from the Pesticide Analytical Manual ( PAM, Vol. I, Section 302).

Adequate storage stability data are available indicating that residues of propiconazole are stable at   15 º C for up to 36 months in peaches, bananas, corn meal, wheat grain, celery, corn oil, and peanut nutmeat, hay, and hulls; 10 months in carrots; and 4 6 months in soybean seed and fodder. Weathered residues of propiconazole and its metabolites were also found to be stable under frozen storage conditions in grass forage, straw, and seed for up to 39 months at  20 º C; wild rice and stone fruits for up to 25 months; and peanut hulls and fodder for 25 months at  15 º C. These data support most of the samples storage intervals and conditions in the field trials and processing studies submitted with the current petitions. In cases where existing storage stability data are not available, concurrent storage stability data were submitted along with field trials.

Provided that minor changes are made to the proposed use directions, the available field trial data on almonds, bush and cane berries, carrots, celery, corn, cranberries, mint, onions, pecans, rice, sorghum, strawberries and wheat are adequate and support the proposed use patterns for propiconazole ( EC or WP) on these crops. The number and geographic distribution of the field trials are adequate, and the appropriate samples were collected. Samples were analyzed using adequate analytical methods and the sample storage intervals are supported by the available storage stability data. Side by side field trials were conducted on almond, celery, field corn, and sugar beets to compare residues from the EC and WP formulation. These data show residues are comparable from the two products, with the exception of sugar beet tops at the requested PHI.

Adequate field trial data are also available to support the use of the 45% WP formulation on sugar beets. However, based on the results of the side by side tests with the WP and EC formulations, residues in/ on tops at the proposed 21 day PHI are likely to be higher for the EC formulation than the WP formulation. Therefore, a complete set of field trial data are required for sugar beet tops reflecting the use of the EC formulation. A conditional registration can be established on sugar beet tops. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 5 of 63 For soybeans, after considering all the available soybean field trial data, HED concluded that sufficient residue data are available to support tolerances on soybean forage and hay harvested 30 days following the second of two applications totaling 0.33 lb ai/ A ( 1x rate). Although the petitioner has requested tolerances for soybean forage and hay, the Agency notes that the currently proposed use directions for soybean prohibit the feeding or grazing for forage or hay. HED also considers sufficient residue data are available to support tolerances on soybean seed, even though the PHIs of the soybean seed data varies from 30 to 90 days. Since soybean mature at different times depending on the growing regions, PHI in days can vary from region to region; therefore, provided the label has such language as " do not apply later than the R5 growth stage' or ` apply up to Stage R6", no additional field trials are required for soybean seeds.

For dry peas and beans, however, there are no sufficient field trial data to support the proposed use as only six dry bean field trials are available and no dry pea field trials were conducted. For a subgroup crop tolerance on 6C, a total of 12 dry bean field trials and 5 dry pea field trials are required. In addition, the available dry bean field trials support a PHI of 28 days rather than the 14 day PHI on the proposed label. HED recommends against the establishment of permanent tolerance on subgroup crop 6C until additional field trial data are submitted.

The Agency's Guidance for Setting Pesticide Tolerances Based on Field Trial Data ( tolerance spread sheet) was utilized for determining appropriate tolerance levels on plant commodities. While these tolerance/ residue levels are suitable for Tier I dietary risk assessment, they are considered conservative for tolerances in that the field trial data were reported as parent plus all metabolites containing 2,4 DCBA, while the tolerance expression is parent only. HED recommends that the registrant analyze parent and metabolites separately in all future field trials, so that more realistic tolerances can be set in the future.

Adequate processing studies are available for alfalfa ( rotational crop), field corn, mint, rice, sorghum, soybean, sugar beet, and wheat. These studies indicate that, with the exception of aspirated grain fractions ( AGF), combined propiconazole residues did not concentrate in processed commodities derived from alfalfa, field corn, mint, sorghum, and soybeans, or in polished rice, sugar beet refined sugar, or wheat germ, shorts, middlings and flour. However, combined residues were shown to concentrate in rice hulls ( 3.8x) and bran ( 2.9x), sugar beet molasses ( 7.4x) and dried pulp ( 4.9x), and wheat bran ( 3.2x). Considering the highest average field trial ( HAFT) residues in the various RACs and the above processing factors, appropriate tolerances for combined propiconazole residues are 20 and 15 ppm for rice hulls and bran, 1.5 and 1.0 ppm for sugar beet molasses and dried pulp, and 0.6 ppm for wheat bran. The recommended tolerance for wheat bran will be translated to bran of barley and rye. With regards to AGF, combined residues were also shown to concentrate by various degrees in AGF derived from field corn ( 12.8x), sorghum ( 5.2x), soybeans ( 32x), and wheat ( 18x) following late season applications. Considering these AGF concentration factors and the HAFT residues in the respective RACs, the maximum expected residues in AGF are 1.28 ppm for corn, 10.9 ppm for sorghum, 30 ppm for soybean, and 3.2 ppm for wheat. Therefore, the recommended tolerance for propiconazole residues in AGF is 30 ppm based on the soybean data.

The maximum theoretical dietary burdens ( MTDB) for combined propiconazole residues were calculated to be 29.0 ppm for beef and 18.5 ppm for dairy cattle, 2.3 ppm for swine and 2.0 ppm Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 6 of 63 for poultry. To estimate maximum combined residues in cattle and swine commodities, the residue levels for the 75 ppm feeding level at 21 days were selected as these residue levels were the highest for the 75 ppm group. This feeding level represents a 2.7x the MTDBs for beef cattle, 4.2x for dairy cattle, and a 32.6x for swine. Maximum combined residues were estimated by dividing the residue values for milk and tissues at the 75 ppm dose level by 2.7 for cattle, 4.2 for milk, and 32.6 for swine. For beef cattle, estimated combined residues at a 1x feeding level are 1.7 ppm for kidney, 1.6 ppm for liver, 0.03 ppm for muscle, 0.05 ppm for fat, and 0.03 pm for milk. For swine, estimated combined residues at a 1x feeding level are 0.14ppm for kidney, 0.13 ppm for liver and < 0.005 ppm for muscle and fat. HED recommends that the following tolerance levels be established: For cattle, goat, horses and sheep, kidney and liver at 2.0 ppm; meat and meat byproduct ( except kidney and liver) and fat at 0.05 ppm, milk at 0.05 ppm. For hog, kidney and liver at 0.20 ppm, no tolerances are needed for meat, fat, and meat byproduct.

For poultry tissues and eggs, estimated combined residues and parent residues were calculated in the same manner as for cattle and swine. The maximum combined residues in tissues and eggs from the 7.5 ppm dose group in the poultry feeding study were used to estimate residues at the 1x feeding level. The estimated combined residues at the 1x feeding level are all < LOQ. Therefore, tolerances for poultry tissues and eggs are not required as quantifiable levels of propiconazole are unlikely to occur in these commodities [ 40 CFR 180.6( a) ( 3)].

Adequate confined rotational crop studies are available indicating that the residues in rotational crops are similar to the primary crops. The confined studies also support the 105 day plant back interval ( PBI) currently listed on product labels for crops without direct uses. Under the current petition, Syngenta has submitted extensive rotational crop field trial data on alfalfa planted following propiconazole treated wheat and proposed a 0.1 ppm tolerance for inadvertent residues in/ on alfalfa. The available alfalfa rotational crop field trials are adequate and will support a 75 day PBI for alfalfa following propiconazole application( s) to primary crops at up to 0.22 lb ai/ A/ season.

Residue Chemistry Deficiencies With the exception of the residue data for dry peas and beans, and sugar beet tops, no major deficiencies were noted in the subject petitions that would preclude establishing permanent tolerances for propiconazole on the proposed commodities. Pending the favorable outcome of the aggregate risk assessment, HED recommends establishing permanent tolerances for propiconazole residues at the levels recommended in the Table 9. As insufficient field trial data are available on dry peas and beans ( subgroup 6C), HED recommends against establishing permanent tolerances on these commodities at this time until additional field trials are submitted. A conditional registration can be established on sugar beet tops. A human health risk assessment is forthcoming.

° Label directions for the EC and WP formulations must be amended to include the recommended changes listed under the ` Directions for use' section.

° To support the use of the EC formulation on sugar beets, an additional 8 sugar beet field trials are required using a representative EC formulation. As the available data indicate that residues in/ on roots are similar for the WP and EC formulations, only residue data on Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 7 of 63 sugar beet tops are required from these trials. HED recommends that registration of the EC on sugar beets be conditional upon the data on tops.

° A total of 12 dry bean field trials and 5 dry pea field trials are required to support the proposed tolerance on the dry pea and bean subgroup 6C. Only five dry bean field trials are available, and they support a 28 day PHI rather than the proposed 14 day PHI. Additional 7 trials on dry beans and 5 trials on dry peas at the proposed rates are needed.

° Since data are available supporting tolerances on soybean forage and hay, the petitioner may delete the " prohibit animal grazing" or " prohibit feeding hay to livestock" on the label.

° The available wheat field trial will only support a maximum use rate of 0.11 lb ai/ A prior to the harvest of forage or hay. Label must be revised to specify that no more than 0.11 lbs ai/ A be applied before the harvest of forage and hay. If the petitioner intends to support the use of two applications totaling 0.22 lb ai/ A prior to harvest of forage and hay, then an additional 8 field trials are required on forage and a complete set of 20 field trials are required for hay.

° The available field corn and sorghum field trial data will only support applications totaling 0.22 lb ai/ A prior to the harvest of forage. If the petitioner intends to support total application rate up to 0.44 lb ai/ A prior to the harvest of forage, than additional field corn and sorghum forage data will be required to support the higher use rate.

° As propiconazole is one of the triazole producing pesticides, any requests for new uses submitted after September 1, 2005 will require data related to assessing the common metabolites. For detailed information, please refer to HED memo of 4/ 25/ 06, M. Doherty, D327788. " Guidance on Residue Chemistry Data Submission". Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 8 of 63 Background Propiconazole is a triazole type fungicide ( Group 3) that provides broad spectrum disease control through inhibition of sterol biosynthesis in fungi. It is registered to Syngenta Crop Protection for the control of fungal diseases on a variety of crops. It is formulated as 3.6 lb/ gal emulsifiable concentrates ( EC) and 45% wettable powder ( WP). Propiconazole end use products are marketed in the United States under the trade names Tilt ® , Alamo ® , Banner ® , and Orbit ® . Recently, propiconazole is also registered for use on a variety of crops under the trade names of Stratego   Twin Pak   and Stratego   , which are end use products containing a mixture of trifloxystrobin and propiconazole.

Permanent tolerances are currently established for the combined residues of propiconazole, 1 [[ 2( 2,4 dichlorophenyl) 4 propyl 1,3 dioxolan 2 yl] methyl] 1H 1,2,4 triazole, and its metabolites determined as 2,4 DCBA and expressed in parent equivalents, at levels ranging from 0.1 ppm on numerous plant commodities to 40 ppm in/ on grass hay and straw [ 40 CFR § 180.434( a)]. Permanent tolerances are also established for the combined residues of propiconazole and its metabolites determined as 2,4 DCBA at 0.1 ppm in fat, meat, and meat byproducts ( except liver and kidney) of livestock, 2.0 ppm in liver and kidney of livestock, and at 0.05 ppm in milk; however, no tolerances have been established for eggs and poultry commodities. Time limited tolerances are established for combined propiconazole residues in/ on a variety of plant commodities at levels from 0.2 ppm in/ on sorghum grain to 25 ppm in/ on soybean hay [ 40 CFR § 180.434( b)]. In addition, tolerances with regional restrictions have been established for combined propiconazole residues at 0.3 ppm in/ on mint tops and 0.5 ppm in/ on wild rice [ 40 CFR § 180.434( c)].

Syngenta previously submitted a series of petitions ( PP# s 4F3007, 4G3075, 5F4424, 5F4591, and 9F3740) supporting the use of propiconazole, formulated as an EC, on tree nuts, corn, cereal grains, legume vegetables, soybeans, berries, strawberry, sugar beet, carrots and onions. These petitions have been superseded by a single petition ( PP# 2F6371), which includes new or amended use directions for the above crops. In conjunction with these petitions, Syngenta is proposing the following permanent tolerances as of 7/ 18/ 05.

AGF .................................................................................................. 17.0 ppm Almond, hulls ..................................................................................... 8.0 ppm Crop group 6, Legume vegetables,.................................................. 1.0 ppm Crop Group 7, Foliage of legume vegetables  .         . 10.0 ppm Crop Group 7, Forage of legume vegetables           32.0 ppm Crop Group 13, Berries ...................................................................... 1.0 ppm Crop Group 15, Cereal Grains ( except corn, rice and sorghum), forage... 3.0 ppm Crop Group 15, Cereal Grains ( except corn, rice and sorghum), and hay .. .2.0 ppm Crop Group 15, Cereal Grains ( except corn, rice and sorghum), and straw... 13.0 ppm Crop Group 15, Cereal Grains ( except corn, rice and sorghum), and bran   2.5 ppm Crop Group 15, Cereal Grains ( except corn, rice and sorghum), and grain   0.5 ppm Carrot.................................................................................................... 0.2 ppm Corn, forage .......................................................................................... 4.0 ppm Corn, grain .......................................................................................... 0.3 ppm Corn, stover......................................................................................... 25.0 ppm Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 9 of 63 Corn, oil ................................................................................................ 0.5 ppm Onion, dry bulb ..................................................................................... 0.3 ppm Onion, green.......................................................................................... 8.0 ppm Pistachio................................................................................................ 0.2 ppm Rice, bran........................................................................................... 28.0 ppm Rice, grain............................................................................................. 7.0 ppm Rice, hulls ........................................................................................... 28.0 ppm Rice, straw .......................................................................................... 18.0 ppm Grain sorghum, forage ...................................................................... 10.0 ppm Grain sorghum, grain............................................................................. 2.5 ppm Grain sorghum, stover ......................................................................... 15.0 ppm Soybean, forage................................................................................... 10.0 ppm Soybean, hay...................................................................................... 32.0 ppm Soybean, seed....................................................................................... 2.0 ppm Strawberry............................................................................................. 1.5 ppm Sugar beet, dried pulp............................................................................ 2.0 ppm Sugar beet, roots.................................................................................... 0.3 ppm Sugar beet, tops ................................................................................... 10.0 ppm Sugar beet, molasses.............................................................................. 3.0 ppm Tree nut crop group............................................................................... 0.2 ppm Milk ...................................................................................................... 0.1 ppm Syngenta has also submitted petition 5F4498 for establishing Inadvertent/ Rotational crop tolerances on alfalfa.

Alfalfa                           0.1 ppm In addition to Syngenta's petition, Interregional Project No. 4 ( IR 4) is also supporting three petitions for an unrestricted use of propiconazole on mint ( PP# 8E4931) and leaf petiole vegetables, subgroup 4B ( PP# 6E4788), and for the restricted use of propiconazole on cranberries grown in WI and the Pacific Northwest ( PP# 7E4860). In conjunction with these petitions, IR 4 is proposing the following new or amended tolerances:

Cranberry .............................................................................................. 1.0 ppm Crop Subgroup 4 B, Leaf petioles subgroup .......................................... 5.0 ppm Mint ...................................................................................................... 3.0 ppm Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 10 of 63 Table 1. Nomenclature of Propiconazole Compound N N N O O Cl Cl Common name Propiconazole Company experimental names CGA 64250 IUPAC name 1[ 2( 2,4_ dichlorophenyl) 4 propyl 1,3 dioxolan 2 ylmethyl] 1H 1,2,4_ triazole CAS name 1[[ 2( 2,4 dichlorophenyl) 4 propyl 1,3 dioxolan 2 yl] methyl] 1H 1,2,4 triazole CAS # 60207 90 1 End use products/ EP 3.6 lb/ gal ECs ( EPA Reg. Nos. 100 617 and 702); 45% WP ( EPA Reg. No. 100 780); 1.04 lb/ gal EC ( EPA Reg. No. 100 1178, MAI with azoxystrobin)

Table 2. Physicochemical Properties of Technical Grade Propiconazole.

Parameter Value Reference Boiling point 120 º C at 1.9 Pa, > 250 º C at 101.325 kPa MRID No. 43698701 pH 4.9 at 25 º C ( 1% aqueous dispersion) MRID No. 43698701 Density 1.289 g/ cm3 at 20 º C MRID No. 43698701 Water solubility 0.10 g/ L at 20 º C MRID No. 41720301 Solvent solubility ( temperature not specified) Completely miscible in ethanol, acetone, toluene and n octanol. hexane = 47 g/ L MRID No. 42030201 Vapor pressure 4.2 x 10 7 mm Hg at 25 º C MRID No. 41720301 Dissociation constant ( pKa) 1.09 MRID No. 43698701 Octanol/ water partition coefficient Log( KOW) 3.72 at pH 6.6 and 25 º C MRID No. 43698701 UV/ visible absorption spectrum ( 8max, nm) Not available MRID No. 40583703 860.1200 Directions for use There are currently five active end use products ( EPs) containing propiconazole that are registered to Syngenta for use on feed/ food crops. These EPs are marketed under the trade names Tilt ® and Orbit   Fungicides, and include: three 3.6 lb/ gal ECs ( EPA Reg. Nos. 100 617, 100 702, and 100 737), a 45% WP ( EPA Reg. No. 100 780), and a multiple active ingredient ( MAI) EC formulation containing 1.04 lb/ gal of propiconazole and 0.62 lb/ gal of asozystrobin ( Quilt   Fungicide; EPA Reg. No. 100 1178). Proposed or amended use directions for these labels are summarized below in Table 3. Uses are based on an example labels provided for the EC formulations ( 1/ 14/ 05) and the approved labels for the WP ( accepted 12/ 11/ 03) and EC MAI ( accepted 3/ 8/ 06). Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 11 of 63 Table 3. Summary of Directions for Proposed Uses of Propiconazole.

Application Timing, Type and Equipment Formulation [ EPA Reg. No.] Single rate ( lb ai/ A) Max. # of Apps. per Season Max. Seasonal Rate ( lb ai/ A) PHI ( days) Use Directions and Limitations 1 Almond Foliar applications beginning at bud break Ground or aerial equipment 3.6 lb/ gal EC [ 100 617] 45% WP [ 100 780] 0.225 4 0.90 NS Apply in a minimum of 20 or 50 gal/ A using aerial and ground equipment, respectively. Minimum RTI is 7 days Do not graze livestock in treated areas or cut treated cover crop for feed Berries ( Bush and Cane berries) and Cranberry Foliar applications beginning at bud break or for cane berries beginning as a delayed dormant application Ground or aerial equipment 3.6 lb/ gal EC [ 100 617] 45% WP [ 100 780] 0.169 5 0.84 30 Apply in a minimum of 5 10 or 20 50 gal/ A using aerial and ground equipment, respectively. The minimum RTI is 7 28 days depending on the disease. Cranberry ( For use Only in Wisconsin and the Pacific Northwest) Broadcast foliar applications from bud break to fruit set 3.6 lb/ gal EC [ 100 702] 0.169 4 0.68 45 Minimum RTI is 10 days Carrots Broadcast foliar applications when conditions favor disease development Ground or aerial equipment 3.6 lb/ gal EC [ 100 617] 45% WP [ 100 780] 0.113 4 0.45 14 Apply in a minimum of 5 or 15 gal/ A using aerial and ground equipment, respectively. Minimum RTI is 7 days Application may include spreader sticker Celery ( Leaf Petiole Vegetables, subgroup 4B) Broadcast foliar applications when conditions favor disease development Ground or aerial equipment 3.6 lb/ gal EC [ 100 617] 1.04 lb/ gal EC [ 100 1178] 45% WP [ 100 780] 0.113 4 0.45 14 Minimum RTI is 7 days Application may include spreader sticker Cereals ( wheat, barley, rye, triticale and oats) 3.6 lb/ gal EC [ 100 617] 0.113 2 0.225 30/ 35/ 45 Do not apply after Feekes Stage 10.5 Minimum RTI is 14 days. 30 and 45 day PHIs are specified for forage and hay, respectively, following an application at Feekes Stage 5. A general 35 day PHI is also specified for grazing or harvest of forage, hay and mature wheat. Broadcast foliar applications up to Flowering ( Feekes Stage 10.5) Aerial or ground equipment, including chemigation 1.04 lb/ gal EC [ 100 1178] 0.113 2 0.167 45 Do not harvest wheat for forage and do not graze or feed livestock treated forage or cut green crop of hay or silage Broadcast foliar applications up to Feekes Stage 8 Aerial or ground equipment, including chemigation 45% WP [ 100 780] 0.113 1 0.113 40 Do not apply after Feekes Stage 8 Do not apply to oats with 40 days of harvest. Except for oat forage and hay, do not graze or feed livestock treated forage or cut the green crop for hay or silage Corn ( field, seed, pop and sweet) Broadcast foliar applications when conditions favor disease development Aerial or ground equipment, including chemigation 3.6 lb/ gal EC [ 100 617] 45% WP [ 100 780] 0.113 4 0.45 14/ 30 Minimum RTI is 7 days. A 14 day PHI is specified for sweet corn forage and ears, and a 30 day PHI is specified for forage, grain and stover of field, pop, and seed corn. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 12 of 63 Table 3. Summary of Directions for Proposed Uses of Propiconazole.

Application Timing, Type and Equipment Formulation [ EPA Reg. No.] Single rate ( lb ai/ A) Max. # of Apps. per Season Max. Seasonal Rate ( lb ai/ A) PHI ( days) Use Directions and Limitations 1 Dry Beans and Peas Broadcast foliar applications when conditions favor disease development Aerial or ground equipment 3.6 lb/ gal EC [ 100 617] 45% WP [ 100 780] 0.113 3 0.338 14 Do not apply to succulent bean varieties Apply in a minimum of 5 or 15 gal/ A using aerial and ground equipment, respectively. Minimum RTI is 14 days Filberts ( Hazelnuts) Foliar applications beginning at bud break Aerial or ground equipment 3.6 lb/ gal EC [ 100 617] 0.225 4 0.90 NS For aerial applications, minimum volumes of 5 10 or 20 gal/ A are recommended. For ground applications, minimum volumes of 10 50 or 100 gal/ A are recommended. Minimum RTI is 14 days Do not graze livestock in treated areas or cut treated cover crop for feed Onions ( green, dry bulb, or seed crop) 2 Broadcast foliar applications when conditions favor disease development Aerial or ground equipment 3.6 lb/ gal EC [ 100 617] 45% WP [ 100 780] 0.225 2 0.45 0 3/ 14 Apply in a minimum of 5 or 15 gal/ A using aerial and ground equipment, respectively. Minimum RTI is 7 days PHIs are 0 for green onions and 14 days for dry bulb onions Peppermint and Spearmint Broadcast foliar applications beginning when plants are 2 4 inches in height Equipment not specified 3.6 lb/ gal EC [ 100 617] 0.113 2 0.225 30 Apply in a minimum of 20 gal/ A Minimum RTI is 10 days Pecans Foliar applications beginning at emergence of green leaves Aerial or ground equipment 3.6 lb/ gal EC [ 100 617] [ 100 702] 1.04 lb/ gal EC [ 100 1178] 45% WP [ 100 780] 0.225 4 0.90 NS Apply in a minimum of 20 gal/ A for aerial applications Minimum RTI is 14 days, Do not apply after shuck split The label for 100 1178 also specifies a 45 day PHI Do not graze livestock in treated areas or cut treated cover crop for feed Pistachios Foliar applications beginning at emergence of green leaves Aerial or ground equipment 3.6 lb/ gal EC [ 100 617] 45% WP [ 100 780] 0.225 4 0.90 NS Apply in a minimum of 20 gal/ A for aerial applications and 50 100 gal/ A for ground applications Minimum RTI is 14 days Do not graze livestock in treated areas or cut treated cover crop for feed Rice ( Do not use in CA)

0.28 1 Broadcast foliar application( s) after tillering Ground or aerial equipment 3.6 lb/ gal EC [ 100 617] 1.04 lb/ gal EC [ 100 1178] 45% WP [ 100 780]

0.169 2 0.338 35 Apply aerially in a minimum of 5 20 gal/ A. Minimum RTI is 10 days The label for the 1.04 lb/ gal EC prohibits applications after head emergence. Do not apply to stubble or ratoon crop. Do not use in rice fields where crayfish farming will be practiced or drain water from treated fields into ponds used for crayfish farming. Do not use water drained from treated fields to irrigate other crops water Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 13 of 63 Table 3. Summary of Directions for Proposed Uses of Propiconazole.

Application Timing, Type and Equipment Formulation [ EPA Reg. No.] Single rate ( lb ai/ A) Max. # of Apps. per Season Max. Seasonal Rate ( lb ai/ A) PHI ( days) Use Directions and Limitations 1 Sorghum Broadcast foliar applications beginning at or just prior to flowering Aerial or ground equipment 3.6 lb/ gal EC [ 100 617] 45% WP [ 100 780] 0.113 4 0.45 21/ 30 Apply in a minimum of 5 or 15 gal/ A using aerial and ground equipment, respectively. PHIs are 30 days for forage and 21 days for grain and stover Minimum RTI is 5 days Soybeans Broadcast foliar applications beginning at first appearance of disease until to pod fill ( Stage R5) Ground and aerial equipment 3.6 lb/ gal EC [ 100 617] 1.04 lb/ gal EC [ 100 1178] 45% WP [ 100 780] 0.169 2 0.338 30 Apply in a minimum of 5 and 15 gal/ A using aerial and ground equipment, respectively. Minimum RTI is 14 days Do not graze or feed soybean forage or hay Strawberries Broadcast foliar applications before disease levels reach 5% Aerial or ground equipment 3.6 lb/ gal EC [ 100 617] 45% WP [ 100 780] 0.113 4 0.45 0 Apply in a minimum of 5 or 15 gal/ A using aerial and ground equipment, respectively. Minimum RTI is 7 days Sugar beets Broadcast foliar applications beginning at first appearance of disease Equipment not specified 3.6 lb/ gal EC [ 100 617] 45% WP [ 100 780] 0.113 3 0.338 21 Minimum RTI is 10 days Tree Nut Crops Foliar application at unspecified timing Ground and aerial equipment 3.6 lb/ gal EC [ 100 617] 45% WP [ 100 780] 0.225 4 0.90 60 Apply in a minimum of 20 for aerial applications, or 50 100 gal/ A for ground applications. Minimum RTI is not specified.

1 Labels include a 24 hour restricted entry interval. Under general use directions, the following rotational crop restriction is listed: do not replant within 105 days of propiconazole application to preceding crop, unless the second crop appears on the label. In addition, minimum application volumes are 5 and 10 gal/ A for aerial and ground applications, respectively, unless otherwise specified. For specified crops, ground applications may include chemigation through center pivot, solid set, hand move, or moving wheel irrigation. 2 Use on dry bulb onions includes garlic, dry bulb onions and dry bulb shallots, and the use on green onions includes green onions, leeks, spring onions or scallions, Japanese bunching onions, green shallots, and green eschalots. 3 For crops with 0 day PHIs ( green onions and strawberry), entry within the 24 hour REI requires use of PPE. RTI = retreatment interval NS = not specified.

° Use directions for tree nuts ( almonds, filberts, and pistachios) should be amended to specify a minimum PHI of 60 days, with the exception of pecans. A specific PHI is not required for pecans as applications to pecans are prohibited after shuck split, and the available pecan field trial data support applications up to shuck split, which is a distinct growth stage. The available almond and pecan field trial data support minimum RTIs of 7 or 14 days and concentrated or dilute application volumes. The use directions for Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 14 of 63 filberts must be clarified to list single minimum volumes for ground and aerial applications.

° Use directions for cranberry should be separated from directions for other berries on all labels. The available cranberry residue data support up to four foliar applications of propiconazole at 0.169 lb ai/ A/ application, from bud break through early fruit development, at minimum RTIs of 14 days, for a maximum of 0.68 lb ai/ A/ season, with 45 day PHI. The use on cranberries should be restricted to Regions 5 and 12.

° Use directions should be standardized between wheat, barley, rye, triticale and oats. The available wheat field trial data will support applications to these cereal grains at up to Feekes Growth Stage 10.5 at a rate of 0.11 lb ai/ A/ application, for a maximum of 0.22 lb ai/ A/ season. The data support a minimum RTI of 14 days and PHIs of 30 days for forage, 45 days for hay, and 40 days for grain and straw. In addition, the available field trial data will only support application( s) at up to 0.11 lb ai/ A prior to the harvest of forage or hay. Unless the petitioner intends to provide additional data on forage and hay supporting use of rates up to 0.22 lb ai/ A, the labels should be amended to specify a maximum total application rate of 0.11 lb ai/ A on wheat, barley, oats or rye harvested for forage or hay.

° For both field corn and sorghum, the available field trial data will only support applications totaling 0.22 lb ai/ A prior to the harvest of forage. Labels should be amended to specify a maximum total application rate of 0.22 lb ai/ A on field corn and sorghum harvested for forage.

° For dry peas and beans, delete these uses.

° The minimum RTI for applications to mint should be changed from 10 to 14 days, and the use directions should specify the types of application equipment allowed ( ground and/ or aerial).

° Base on the rice field trial data, the minimum RTI for spilt applications to rice should be changed from 10 to 14 days.

° Although label directions for soybeans prohibit the feeding or grazing of forage or hay, tolerances have been proposed for soybean forage and hay and adequate data are available for these commodities. Therefore, this feeding restriction can be removed from the label.

° The available strawberry field trial data support a minimum application volume of 50 gal/ A rather than 5 gal/ A.

° Base on the available alfalfa rotational crop data, labels can be amended to include at 75 day plant back interval for the rotation of alfalfa following primary crops treated with up to a total seasonal rate of 0.22 lb ai/ A of propiconazole. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 15 of 63 860.1300 Nature of the Residue   Plants.

Propiconazole RED, DP Barcode D329394, Y. Donovan, 6/ 15/ 06 45206201. der ( carrot metabolism)

The nature of propiconazole residues in plants is adequately understood. Initial metabolism studies on peanuts, wheat, grapes and rice were summarized in the Phase 4 Review and indicated that the metabolite profile was similar in both the primary and rotational crops; however, complete quantitative data were not available from these studies. Additional studies have since been conducted on celery, wheat, and carrots that were deemed completely adequate. Together these data indicate that the major metabolic pathway in plants appears to involve hydroxylation of the n propyl group on the dioxolane ring of the cis/ trans isomers of propiconazole, with subsequent conjugation to sugars. A possible alternative pathway involves reductive deketalization of the dioxolane ring and sugar conjugation of the resulting metabolite. The alkyl bridge between the phenyl and triazole rings is metabolized and free 1H 1,2,4 triazole is released. The free triazole is readily conjugated with the amino acid, serine/ alanine, forming triazole aniline which is further metabolized to triazole acetic acid possibly through the intermediate formation of triazole lactic acid. The free triazole, triazole alanine, and triazole acetic acid are also residues of concern. Since these are common metabolites from several triazole containing pesticides, the risk assessment for triazoles has been assessed separately ( HED memo of 2/ 7/ 06, M. Doherty, D322215). The cited assessment included all the proposed propiconazole new uses in the subject petitions.

Based on these studies, HED concluded that the residues of concern for dietary risk assessment ( food) should include propiconazole and all its metabolites containing the 2,4 DCBA moiety, including conjugates, as virtually all the residue data have been generated using a common moiety method that converts parent and all of the metabolites of concern to 2,4 DCBA. However, only residues of propiconazole per se should be included in water for purposes of the dietary risk assessment. The tolerance expression should also be amended to include only propiconazole per se because 1) there are a number of pesticides that have 2,4 DCBA as common metabolite, and an enforcement agency may not be able to determine if residues are due to misuse of propiconazole or the proper use of other pesticides containing 2,4 DCBA; 2) propiconazole per se can be detected by FDA multiresidue methods; and 3) inclusion of only parent allows harmonization with the residue definition for the Codex MRLs. Although HED also considers free triazole to be a residue of concern in plants, issues pertaining to triazole residues are addressed in a separate document.

860.1300 Nature of the Residue   Livestock.

Propiconazole RED, DP Barcode D329394, Y. Donovan, 6/ 15/ 06 The nature of propiconazole residues in livestock is adequately understood based on the acceptable goat and poultry metabolism studies. In one ruminant study, three lactating goats received [ phenyl 14C] propiconazole at 67 92 ppm for four consecutive days in the feed. The dosing levels correspond to 1.7 2.3x the MTDB for dairy cattle. The parent ( 1.7 13.9% TRR), and metabolites CGA 118244 ( 9.4 34% TRR), and CGA 91305 ( 15.9 31.3% TRR) were Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 16 of 63 identified in the organic extract of tissues; metabolites CGA 118244 ( 23% TRR) and CGA 91305 ( 24% TRR) were also identified in milk. In addition, an unknown was quantified ( 6.2 31.1% TRR) in goat tissues. In a second ruminant study, a single goat was fed [ triazole 14C] propiconazole at 4.53 ppm ( 0.1x) for 10 days. The TRR in tissues and milk ranged from 0.01 ppm in muscle to 0.96 ppm in liver; TRR in milk were 0.015 ppm. On further analysis of subsamples of milk and liver, sulfate and glucuronide conjugates were found in milk, and conjugation with amino acids was suggested in liver; propiconazole per se was not identified in milk or liver.

In the poultry study, four laying hens received [ phenyl 14C] propiconazole at 67 ppm for eight consecutive days in feed. The dosing level corresponds to 7.3x MTDB for poultry. The parent ( 1.4 39.0% TRR), and metabolites CGA 118244 ( 1.5 50.0% TRR), and CGA 91305 ( 17.7 78.6% TRR) were identified in the organic extracts of tissues and eggs.

The Agency concluded that parent and all metabolites convertible to 2,4 DCBA are residues of concern for risk assessment, as the analytical method is a common moiety method that detects all residues convertible to 2,4 DCBA. However, for tolerance enforcement purposes, the current tolerance expression should be amended to include only propiconazole per se.

860.1340 Residue Analytical Methods.

Propiconazole RED, DP Barcode D329394, Y. Donovan, 6/ 15/ 06 Plant commodities: Samples from the various field trials and processing studies supporting the current petitions were analyzed for combined residues of propiconazole and its 2,4 DCBA containing metabolites using GC/ ECD Methods AG 454B and AG 626, which are more recent versions of the original tolerance enforcement method ( AG 454). Samples from two of the cranberry field trials used a modification to AG 454, in which a nitrogen phosphorus detector ( NPD) was used instead of the ECD. All of these methods are similar common moiety methods in which residues are converted by base hydrolysis and oxidation to 2,4 DCBA, then determined as the 2,4 DCBA methyl ester, and reported in propiconazole equivalents using a conversion factor of 1.79. With the exception of almond hulls, which had a LOQ of 0.1 ppm, the validated LOQ for combined residues was 0.05 ppm in all raw and processed commodities. Each of the methods was validated in conjunction with the field trials and processing studies, and acceptable concurrent method recoveries were obtained for all crop matrices.

In addition to determining combined residues, samples from one of the wheat field trials and processing studies were also analyzed for residues of propiconazole, per se, using a GC/ NPD method from PAM Vol. I ( Method 302 E4 + DG5). This method was also adequately validated in conjunction with the analysis of field trial samples, and the validated LOQ was 0.05 ppm.

In the majority of field trials and processing studies submitted for these petitions, the petitioner reported corrected residue values for samples with procedural recoveries of < 100%. However, when available, uncorrected residue data are reported in this review and were used in determining tolerance levels. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 17 of 63 For enforcement purposes, residue Method AG 354 is available for determining propiconazole per se in/ on plant commodities using gas chromatography and flame ionization detection, and the reported LOQ is 0.05 ppm. In addition, Multiresidue Methods Section 302 can also be used to detect parent propiconazole.

Animal commodities: GC/ ECD Methods AG 517 and AG 629 ( a modification of method AG 517) are available for determining residues of propiconazole and its 2,4 DCBA containing metabolites in animal commodities. These methods use a single moiety detection in which residues are converted to 2,4 DCBA, determined as the 2,4 DCBA methyl ester, and reported as propiconazole equivalents using a conversion factor of 1.79. The method LOQ is 0.05 ppm for residues in meat, poultry, and eggs and 0.02 ppm for residues in milk. Samples from the ruminant and poultry feeding studies were analyzed using method AG 359 ( an early version of method AG 517) and method AG 517. For enforcement purpose, the Multiresidue Methods Section 302 ( Luke Method; Protocol D) will detect residues of parent propiconazole.

GLN 860.1360: Multiresidue Methods The FDA PESTDATA database ( PAM Volume I, Appendix I) indicates that propiconazole is completely recovered (> 80%) using Multiresidue Methods Section 302. The recovery of propiconazole metabolites CGA 91305, CGA 118244, and 1,2,4 triazole is variable using Section 302. Propiconazole and metabolites CGA 91305, CGA 118244, and 1,2,4 triazole are not recovered using Multiresidue Methods Sections 303 and 304.

860.1380 Storage Stability.

Propiconazole RED, DP Barcode D329394, Y. Donovan, 6/ 15/ 06 Adequate storage stability data are available indicating that residues of propiconazole and its metabolites determined as 2,4 DCBA are stable at   15 º C for up to 36 months in peaches, bananas, corn meal, wheat grain, celery, corn oil, and peanut nutmeat, hay, and hulls; 10 months in carrots; and 4 6 months in soybean seed and fodder. Weathered residues of propiconazole and its metabolites were also found to be stable under frozen storage conditions in grass forage, straw, and seed for up to 39 months at  20 º C; wild rice and stone fruits for up to 25 months; peanut hulls and fodder for 25 months at  15 º C; and in extracts of silage stage corn forage and soybeans for 3 and 8 months, respectively, at 4 º C. These storage stability data are adequate to validate the storage intervals and conditions of samples collected from the current field and processing studies. In cases where existing storage stability data are not available, concurrent storage stability data were submitted along with field trials and / or processing studies.

Adequate Storage stability data are also available on animal commodities to support the existing livestock feeding studies. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 18 of 63 860.1400 Water, Fish, and Irrigated Crops With the exception of rice, propiconazole is not registered for direct use on water and aquatic food and feed crops. Although propiconazole is registered for use on rice, current label restrictions prohibit the use on rice in CA ( where typical agricultural practices for rice field irrigation entail a " flow through" system); typical agricultural practices concerning rice field irrigation in all other areas allow for the on site evaporation of waters used in rice fields. Label restrictions preclude the use of water drained from treated rice fields to irrigate other crops. Label restrictions also preclude use where catfish and crayfish are produced. Therefore, no residue chemistry data are required under these guideline topics.

860.1460 Food Handling This guideline requirement is not relevant to the current petition as no food handling uses are being proposed for propiconazole.

860.1480 Meat, Milk, Poultry, and Eggs Propiconazole RED, DP Barcode D329394, Y. Donovan, 6/ 15/ 06 The maximum theoretical dietary burdens ( MTDB) for combined propiconazole residues were calculated to be 29.0 ppm for beef and 18.5ppm for dairy cattle, 2.3 ppm for swine and 2.0 ppm for poultry. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 19 of 63 Table 4. Calculation of Maximum Dietary Burdens of Livestock for Propiconazole Residues.

Feed Commodity % Dry Matter 1 % Diet 1 Current or Recommended Tolerance ( ppm) Dietary Contribution ( ppm) 2 Beef Cattle Grass, hay [ R] 88 50 40 22.7 Corn field, grain [ CC] 88 20 0.3 0.07 Rice, bran [ R] 88 10 28 3.2 Aspirated grain fractions [ CC] 85 5 45 2.65 Soybean seed [ PC] 89 15 2.0 0.34 TOTAL 100 29.0 Dairy Cattle Grass, hay [ R} 88 30 40 13.6 Corn, field, stover [ R] 83 15 25.0 4.52 Corn, field, grain [ CC] 88 40 0.3 0.14 Soybean seed [ PC] 89 15 2.0 0.34 TOTAL 100 18.5 Poultry Wheat grain [ CC] 89 60 0.5 0.34 Rice, grain [ CC] 88 20 7.0 1.6 Soybean, seed [ PC] 89 20 2.0 0.45 TOTAL 100 2.0 Swine Corn field, grain [ CC] 88 60 0.3 0.20 Rice, grain [ CC] 88 20 7.0 1.6 Soybean, seed [ PC] 89 20 2.0 0.45 TOTAL 100 2.3 1 Table 1 ( OPPTS Guideline 860.1000). 2 Contribution = ([ tolerance /% DM] X % diet) for beef and dairy cattle; contribution = ([ tolerance] X % diet) for poultry and swine. NA = not applicable.

An adequate dairy cattle feeding study is available reflecting dosing with propiconazole at levels equivalent to 15, 75, and 150 ppm in the diet for periods up to 14, 21 and 28 days. Samples of milk were collected daily and tissues samples were collected at study termination. Combined propiconazole residues, determined as 2,4 DCBA and expressed in parent equivalents, were determined using an adequate GC/ FID method ( AG 359) and an adequate GC/ ECD method ( AG 517). Combined propiconazole residues in cattle tissues are summarized below in Table 5. For milk, combined residues were nondetectable (< 0.01 ppm) at the 15 ppm dose level and were detected at 0.10 and 0.11 ppm at the 75 and 150 ppm dosing levels, respectively.

An adequate laying hen feeding study is also available reflecting dosing with propiconazole at levels equivalent to 7.5, 37.5, and 75 ppm in the diet for periods up to 14, 21 and 28 days. Samples of eggs were collected daily and tissues samples were collected at study termination. Combined propiconazole residues, determined as 2,4 DCBA and expressed in parent equivalents, were determined using an adequate GC/ FID method ( AG 359) and an adequate GC/ ECD method ( AG 517). Combined propiconazole residues in poultry tissues are summarized below in Table 6. For whole eggs, combined residues were nondetectable (< 0.05 Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 20 of 63 ppm) at the 7.5 ppm feeding level and were detected at 0.18 and 0.37 ppm at the 37.5 and 175 ppm feeding levels respectively.

Table 5. Total Combined Propiconazole Residues in Dairy Cattle Tissues From Feeding Studies Conducted at Dosing Levels Equivalent to 15, 75, and 150 ppm in the Diet ( 0.4x, 1.9x, and 3.8x MTDB). 1 Dosing Duration 14 days 21 days 28 days Dosing Level ( ppm) 15 75 150 15 75 150 15 75 150 Muscle < 0.05 0.11 0.18 < 0.05 0.08 2 0.13 < 0.05 0.05 0.11 Kidney 0.61 3.04 6.48 0.56 4.68 2 5.0 0.63 3.68 5.50 Liver 0.5 4.0 4.6 0.81 4.3 2 5.3 0.57 2.7 5.6 Fat < 0.05 0.23 0.26 < 0.05 0.15 2 0.19 < 0.05 0.08 0.17 1 Data were obtained from Propiconazole RED, Y. Donovan, 6/ 15/ 06. 2 Residue values in shaded cells were used to calculate maximum potential combined residues in ruminants and swine at 1x feeding level.

Table 6. Total Combined Propiconazole Residues in Hen Tissues From Feeding Studies Conducted at Dosing Levels Equivalent to 7.5, 37.5, and 75 ppm in the Diet ( 0.8x, 4.1x, and 8.2x MTDB). 1 Dosing Duration 14 days 21 days 28 days Dosing Level ( ppm) 7.5 37.5 75 7.5 37.5 75 7.5 37.5 75 Muscle < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 0.07 2 < 0.05 < 0.05 0.06 Liver < 0.1 0.10 0.47 2 < 0.05 0.08 0.39 0.1 0.16 0.30 Fat < 0.05 < 0.05 0.11 2 < 0.05 < 0.05 0.06 < 0.05 < 0.05 0.05 1 Data were obtained from Propiconazole RED, Y. Donovan, 6/ 15/ 06. 2 Residue values in shaded cells were used to calculate maximum potential combined residues in poultry at 1x feeding level.

To estimate maximum combined residues in cattle and swine commodities, the residue levels for the 75 ppm feeding level at 21 days were selected as these residue levels were the highest for the 75 ppm group. This feeding level represents a 2.7x the MTDBs for beef cattle, 4.2x for dairy cattle, and a 32.6x for swine. Maximum combined residues were estimated by dividing the residue values for milk and tissues at the 75 ppm dose level by 2.7 for cattle, 4.2 for milk, and 32.6 for swine. For beef cattle, estimated combined residues at a 1x feeding level are 1.7 ppm for kidney, 1.6 ppm for liver, 0.03 ppm for muscle, 0.05 ppm for fat, and 0.03 pm for milk. For swine, estimated combined residues at a 1x feeding level are 0.14ppm for kidney, 0.13 ppm for liver and < 0.005 ppm for muscle and fat. HED recommends that the following tolerance levels be established: For cattle, goat, horses and sheep, kidney and liver at 2.0 ppm; meat and meat byproduct ( except kidney and liver) and fat at 0.05 ppm, milk at 0.05 ppm. For hog, kidney and liver at 0.20 ppm, no tolerances are needed for meat, fat, and meat byproduct.

For poultry tissues and eggs, estimated combined residues and parent residues were calculated in the same manner as for cattle and swine. The maximum combined residues in tissues and eggs from the 7.5 ppm dose group in the poultry feeding study were used to estimate residues at the 1x feeding level. The estimated combined residues at the 1x feeding level are all < LOQ. Therefore, tolerances for poultry tissues and eggs are not required as quantifiable levels of propiconazole are unlikely to occur in these commodities [ 40 CFR 180.6( a)( 3)].

860.1500 Crop Field Trials Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 21 of 63 43655612. der ( corn) 44757207. der1 ( sugar beet) 45080809. der ( corn) 43655613. der ( celery) 44757208. der1 ( wheat) 45050811. der1 ( rice) 44338101. der ( cranberry) 44757210. der ( almond) 45275801. der ( sorghum) 44416501. der ( mint) 45080807. der ( sugar beet) 45542401. der ( strawberry) 46473001. der ( soybean) 46576301. der ( soybean)

Syngenta and IR 4 have submitted field trials supporting new or amended uses for propiconazole ( EC and/ or WP) on almonds, celery, field and pop corn, cranberry, mint, rice, sorghum, soybeans, strawberries, sugar beets and wheat. The results from these studies are discussed below and summarized in Table 7. In addition, previously reviewed field trial data on berries, beans ( dry), carrots, celery, onions, soybeans, and tree nuts are also summarized below.

Table 7. Summary of Residue Data from Crop Field Trials with Propiconazole ( EC and/ or WP). Combined Residues ( ppm) 1 Crop/ Commodity MRID# Total Appl. Rate ( lb ai/ A) End use Product PHI ( days) n Min. Max. HAFT2 Median 3 ( STMdR) Mean 3 ( STMR) Std. Dev.

Almonds ( 0.90 lb ai/ A total application rate, 60 day PHI) 45% WP 12 < 0.05 0.07 0.07 0.025 0.035 0.018 Nutmeats 3.6 lb/ gal EC 53 63 12 < 0.05 0.09 0.08 0.025 0.041 0.024 45% WP 12 0.57 4.60 4.45 1.20 1.78 1.36 Hull 44757210 & 45215806 0.88 0.91 ( 1x) 4 3.6 lb/ gal EC 53 63 12 0.67 4.20 4.00 1.85 2.06 1.06 Dry Beans ( 0.34 lb ai/ A total application rate, 14 day PHI) Vines 7 10 1.20 7.50 6.20 2.10 3.11 2.17 Hay 23 28 10 0.17 4.90 4.85 1.70 2.11 1.68 Beans 0.41 ( 1.2x) 23 31 10 < 0.05 0.13 0.12 0.08 0.08 0.04 Vines 7 3 1.90 9.90 9.90 4.70 5.50 4.06 Hay 25 28 3 1.10 15.0 15.0 1.80 5.97 7.83 Beans 43386501 0.83 ( 2.5x) 3.6 lb/ gal EC 25 28 3 < 0.05 0.10 0.10 0.10 0.08 0.04 Berry Crop Group ( 0.84 lb ai/ A total application rate, 30 day PHI) Bush and Cane berries 43786403 0.85 ( 1x) 3.6 lb/ gal EC 30 12 0.14 0.66 0.62 0.35 0.36 0.16 Carrot ( 0.45 lb ai/ A total application rate, 14 day PHI)

Roots 43786402 0.44 ( 1x) 3.6 lb/ gal EC 13 14 14 < 0.05 0.17 0.16 0.10 0.10 0.003 Celery ( 0.45 lb ai/ A total application rate, 14 day PHI)

40783301 0.44 0.55 ( 1 1.3x) 3.6 lb/ gal EC 14 20 0.27 4.98 4.98 0.60 1.13 1.28 3.6 lb/ gal EC 14 2 0.27 0.42 0.35 0.35 0.35 0.11 Untrimmed stalks 43655613 0.44 ( 1x) 45% WP 14 2 0.43 0.51 0.47 0.47 0.47 0.06 Corn, field and pop ( 0.45 lb ai/ A total application rate, 30 day PHI) Forage 0.22 ( 0.5x) 29 32 36 < 0.05 1.90 1.45 0.36 0.45 0.49 Stover 48 0.92 19.60 15.9 5.65 6.87 4.75 Grain 45080809 & 45080810 0.42 0.47 ( 1x) 1.04 lb/ gal EC 28 35 48 < 0.05 0.15 0.10 0.025 0.037 0.024 3.6 lb/ gal EC 4 < 0.05 1.26 1.18 0.56 0.60 0.67 Forage 0.44 ( 1x) 45% WP 30 31 4 < 0.05 1.66 1.42 0.64 0.74 0.81 3.6 lb/ gal EC 4 < 0.05 2.15 1.93 0.87 0.98 1.11 Stover 0.44 ( 1x) 45% WP 93 118 4 < 0.05 2.51 2.35 1.13 1.20 1.34 3.6 lb/ gal EC 4 < 0.05 < 0.05 < 0.05 0.025 0.025 0.00 Grain 43655613 0.44 ( 1x) 45% WP 93 118 4 < 0.05 < 0.05 < 0.05 0.025 0.025 0.00 Cranberry ( 0.68 lb ai/ A total application rate, 45 day PHI) Cranberry 44338101 0.66 0.68 3.6 lb/ gal 43 44 6 0.18 0.59 0.53 0.23 0.32 0.17 Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 22 of 63 Table 7. Summary of Residue Data from Crop Field Trials with Propiconazole ( EC and/ or WP). Combined Residues ( ppm) 1 Crop/ Commodity MRID# Total Appl. Rate ( lb ai/ A) End use Product PHI ( days) n Min. Max. HAFT2 Median 3 ( STMdR) Mean 3 ( STMR) Std. Dev. & 45778901 ( 1x) EC Mint ( 0.225 lb ai/ A total application rate, 30 day PHI)

Mint, hay 44416501 0.224 0.227 ( 1x) 3.6 lb/ gal EC 29 30 10 0.06 2.7 2.3 1.1 1.15 0.73 Onions ( 0.45 lb ai/ A total application rate, PHIs 0 day for green onion and 14 days for dry bulb) Green whole plant 0 28 0.57 7.5 5.2 2.1 2.4 0.27 Dry bulb 43786401 0.44 ( 1x) 3.6 lb/ gal EC 14 28 < 0.05 0.18 0.13 0.03 0.05 0.02 Rice 5 ( 0.34 lb ai/ A total application rate, 35 day PHI) Straw 32 0.69 17.0 16.5 2.30 4.11 4.62 Grain 0.28 ( 1x) 3.6 lb/ gal EC 34 49 32 0.03 5.20 5.05 0.89 1.49 1.55 Straw 8 0.77 9.50 8.00 2.40 3.46 3.10 Grain 45080811 0.31 ( 1x) 1.04 lb/ gal EC 35 40 8 0.06 2.50 2.00 0.61 1.01 1.00 Sorghum ( 0.45 lb ai/ A total application rate, PHIs are 30 days for forage and 21 days for grain and stover) 0 14 1.8 11.6 10.7 5.4 6.29 2.54 29 31 24 1.5 8.2 8.1 3.8 4.40 1.92 Forage 0.22 ( 0.5x) 37 38 6 4 3.8 8.3 7.4 6.5 6.28 1.86 18 22 24 2.8 11.7 9.2 5.5 5.81 2.25 Stover 28 6 4 4.3 14.2 13.5 8.6 8.90 5.29 18 22 24 0.52 2.3 2.1 0.98 1.14 0.51 Grain 45275801 0.44 ( 1x) 3.6 lb/ gal EC 28 6 4 1.8 2.4 2.1 2.0 2.05 0.26 Soybean ( 0.34 lb ai/ A total application rate, 30 day PHI) Forage 28 0.33 5.40 5.20 1.85 2.42 1.64 Hay 21 32 28 0.48 21.0 21.0 2.90 4.78 5.29 Seed 26 0.06 0.80 0.47 0.19 0.22 0.15 Fodder 43386502 0.33 ( 1x) 3.6 lb/ gal EC 41 99 28 < 0.05 6.20 5.40 0.58 1.15 1.48 0.32 0.35 7 8 0.56 1.40 1.40 0.72 0.86 0.34 0.23 0.25 7 8 0.10 0.67 0.63 0.16 0.27 0.23 Seed 46473001 0.34 0.36 7 3.6 lb/ gal EC 30 8 0.17 0.94 0.90 0.23 0.39 0.32 Seed 0.24 0.26 19 24 40 < 0.10 0.268 0.215 0.05 0.09 0.052 Forage 0.24 0.25 0 40 1.70 12.0 8.43 4.37 4.90 2.32 Hay 46576301 0.24 0.25 1.04 lb/ gal EC 0 40 2.63 8.43 26.4 12.1 12.74 5.66 Strawberry ( 0.45 lb ai/ A total application rate, 0 day PHI)

Strawberry 45542401 044 ( 1x) 3.6 lb/ gal EC 0 16 0.07 0.69 0.60 0.32 0.35 0.19 Sugar Beet ( 0.34 lb ai/ A total application rate, 21 day PHI) 0 22 < 0.05 0.61 0.565 0.025 0.086 0.160 Roots 0.33 ( 1x) 21 23 22 < 0.05 0.08 0.065 0.025 0.035 0.018 0 22 0.89 5.20 5.05 2.25 2.52 1.17 Tops 44757207 0.33 ( 1x) 45% WP 21 23 22 0.41 2.90 2.85 0.75 1.10 0.80 0 8 < 0.05 0.42 0.30 0.11 0.14 0.12 Roots 21 8 < 0.05 0.23 0.17 0.11 0.13 0.06 0 8 2.10 6.10 5.20 3.75 4.05 1.26 Tops 0.33 ( 1x) 45% WP 21 8 0.74 2.60 2.60 1.50 1.67 0.67 0 8 < 0.05 0.34 0.28 0.11 0.15 0.10 Roots 21 8 0.05 0.23 0.18 0.17 0.14 0.06 0 8 2.60 8.00 5.65 3.70 4.44 1.86 Tops 45080807 0.33 ( 1x) 1.04 lb/ gal EC 21 8 0.77 9.20 7.90 2.85 3.67 2.84 Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 23 of 63 Table 7. Summary of Residue Data from Crop Field Trials with Propiconazole ( EC and/ or WP). Combined Residues ( ppm) 1 Crop/ Commodity MRID# Total Appl. Rate ( lb ai/ A) End use Product PHI ( days) n Min. Max. HAFT2 Median 3 ( STMdR) Mean 3 ( STMR) Std. Dev.

Wheat ( 0.22 lb ai/ A total application rate, PHIs are 30, 45 and 35 days of forage, hay and grain) Total Combined Residues 0 24 1.20 10.70 8.70 3.75 4.37 2.29 Forage 30 32 24 0.09 1.70 1.50 0.60 0.70 0.48 Straw 24 < 0.05 4.20 3.85 0.84 0.98 1.04 Grain 44411206 0.22 ( 1x) 3.6 lb/ gal EC 54 91 24 < 0.05 0.08 0.06 0.03 0.03 0.02 Forage 29 32 42 < 0.05 1.91 1.58 0.20 0.33 0.35 Hay 0.11 ( 0.5x) 43 50 42 < 0.05 1.10 1.04 0.23 0.30 0.25 Straw 42 0.41 6.21 5.32 1.59 2.02 1.25 Grain 0.11 0.12 ( 0.5x) 27 57 42 < 0.05 0.13 0.09 0.03 0.04 0.03 Straw 42 0.20 8.27 7.49 2.71 3.31 2.17 Grain 44757208 0.22 0.23 ( 1x) 3.6 lb/ gal EC 27 57 42 < 0.05 0.20 0.18 0.05 0.07 0.06 Parent Residues 8 Forage 29 32 42 < 0.05 0.49 0.36 0.025 0.06 0.08 Hay 0.11 ( 0.5x) 43 50 42 < 0.05 0.20 0.16 0.025 0.04 0.03 Straw 42 < 0.05 1.63 1.62 0.19 0.45 0.51 Grain 0.11 0.12 ( 0.5x) 27 57 42 < 0.05 0.03 < 0.05 0.025 0.025 0.00 Straw 42 < 0.05 3.49 3.21 0.25 0.73 0.91 Grain 44757208 0.22 0.23 ( 1x) 3.6 lb/ gal EC 27 57 42 < 0.05 0.05 < 0.05 0.025 0.025 0.00 1 Unless otherwise indicated, total propiconazole residues were determined as 2,4 DCBA and are expressed in parent equivalents. The method LOQ for propiconazole residues is 0.05 ppm. Residues are not corrected for procedural recoveries. For calculation of the median, mean, and standard deviation, ½ LOQ ( 0.025 ppm) was used for samples with residues < LOQ. 2 HAFT = Highest Average Field Trial. 3 STMdR = Supervised Trial Median Residue; STMR = Supervised Trial Mean Residue. 4 The field trial application rate relative to the maximum proposed use rate is listed in parentheses. 5 The rice field trial data reflect the use of propiconazole ( EC) on rice as either a single application during heading at up to 0.28 lb ai/ A or a split application during heading totaling 0.31 lb ai/ A. Side by side tests of the two treatments showed no differences in residue in/ on grain and straw between the two treatments. 6 For the sorghum field trials, residue values from sampling intervals later than the proposed PHI will be included in the database used for calculating tolerances, as residue levels at these later intervals were equivalent or higher than residues observed around the proposed PHIs. 7 The three application regimes on soybean were, from top to bottom: 3 applications at 0.11 lb ai/ A ( totaling 1x rate), 2 applications at 0.11 lb ai/ A ( totaling 0.67x rate), and 2 applications at 0.17 lb ai/ A ( totaling 1x rate). Data from the bottom row were used in determining tolerance sine it represent the proposed use pattern. 8 Wheat samples were also analyzed using a method which determined only residues of propiconazole.

Root and Tuber Vegetables Group Carrot. Field trial data on carrots have been previously reviewed ( DP Barcode D219664, L. Kutney, 6/ 14/ 96). In a total of 10 field trials conducted during 1994 1995 in CA, FL, MI, NY, OH, TX and WA, propiconazole ( 3.6 lb/ gal EC) was applied to carrots as four broadcast foliar applications at 0.11 lb ai/ A/ application ( 1x rate, 7 tests) or 0.22 lb ai/ A/ application ( 2x rate, 3 tests), at unspecified RTIs, for totals of 0.44 or 0.88 lb ai/ A ( 1x and 2x seasonal rates). Applications were made in 25 gal of water/ A, and included the use of a spreader/ sticker at 1% v/ v. A single control and single ( 2x tests) or duplicate ( 1x tests) treated samples of carrot roots were collected at 13 14 DAT. Samples were stored frozen from collection to analysis for up to 7 months, an interval supported by the available storage stability data. Total residues of propiconazole and its 2,4 DCBA containing metabolites in/ on carrots were determined using GC/ ECD Method AG 454B, which has a validated method LOQ of 0.05 ppm. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 24 of 63 Following four broadcast applications of propiconazole ( EC) totaling 0.44 lb ai/ A ( 1x rate), residues were < 0.05 0.17 ppm in/ on 14 carrot samples harvested 13 14 DAT, with three samples having residues < LOQ. Average and median residues were 0.01 ppm in/ on carrots treated at 1x. In the three tests conducted at a 2x rate ( 0.88 lb ai/ A), residues were 0.10 0.17 ppm in/ on 3 samples from 14 DAT, and averaged 0.13 ppm.

The carrot field trial data are adequate. Although only seven of the required 8 field trials were conducted at the 1x rate, three additional field trials were conducted at a 2x rate and residues in these tests were all below the recommended tolerance.

Sugar beet. In one set of 11 field trials conducted in 1997 ( 44757207. der1), propiconazole ( 45% WP) was applied to sugar beets as three broadcast foliar applications during tuber development at 0.11 lb ai/ A/ application, for a total of 0.33 lb ai/ A/ season. Applications were made at retreatment intervals ( RTIs) of 9 12 days, with the exception of one site, which had RTIs of 6 and 14 days. At one field site in MN, two additional plots were also treated similarly with three applications of propiconazole ( WP) at 0.33 and 0.55 lb ai/ A/ application ( 3x and 5x rates), to provide samples for a processing study. Single control and duplicate treated samples of sugar beet roots and tops were harvested from each site at 0 and 21 23 days after the third application ( DAT). At two sites, duplicate samples of roots and tops were collected at 0, 7, 14, 21 and 28 DAT to examine residue decline. Sugar beet root and top samples were stored frozen for up to 9.9 months prior to extraction for analysis. Adequate storage stability data are available to support the storage intervals and conditions for the current field trials. Combined residues of propiconazole and its 2,4 dichlorobenzoic acid ( DCBA) containing metabolites in/ on sugar beet roots and tops were determined using an adequate GC/ ECD method ( Method AG 454B). Concurrent recoveries were conducted and the % recoveries are acceptable. Total propiconazole residues in/ on sugar beet roots were < 0.05 0.61 ppm at 0 DAT and < 0.05 0.12 ppm at 21 23 DAT, and total residues in/ on tops were 0.89 5.2 ppm at 0 DAT and 0.41 2.9 ppm at 21 23 DAT. Average residues in/ on roots and tops were respectively 0.09 and 2.52 ppm at 0 DAT and 0.04 and 1.10 ppm at 21 23 DAT. The highest average field trial ( HAFT) residues in/ on roots and tops were respectively 0.57 and 5.1 ppm at 0 DAT and 0.08 and 2.9 ppm at 21 23 DAT. In the two residue decline tests, residue levels in/ on roots were low and remained relatively steady from 0 to 28 DAT, averaging 0.053 ppm at 0 DAT, 0.064 ppm at 14 DAT, and 0.054 ppm at 28 DAT. However, residues in/ on tops declined steadily at longer post treatment intervals, averaging 2.68 ppm at 0 DAT, 1.15 ppm at 14 DAT and 0.68 ppm at 28 DAT.

The number of trials and the geographic representations are adequate. These field trial data will support the use of propiconazole ( WP) on sugar beets as up to three broadcast foliar applications at 0.11 lb ai/ A/ application, at a minimum RTI of 10 days, for a total of 0.33 lb ai/ A/ season, with either a 0 or 21 day pre harvest interval.

In another set of sugar beet field trials conducted in 1998 ( 45080807. der1), propiconazole was applied to sugar beets in 4 side by side tests comparing the use of 45% WP and 1.04 lb/ gal EC formulations. In each test, propiconazole ( WP or EC) was applied to sugar beets as three broadcast foliar applications during tuber development at 0.11 lb ai/ A/ application, at retreatment intervals of 10 11 days, for a total of 0.33 lb ai/ A/ season. Single control and duplicate treated Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 25 of 63 samples of sugar beet roots and tops were harvested from each site at 0 and 21 DAT. Samples were stored frozen from collection to analysis for up to 9.2 months, an interval supported by available storage stability data. Combined residues of propiconazole and its 2,4 dichlorobenzoic acid ( DCBA) containing metabolites in/ on sugar beet roots and tops were determined using an adequate GC/ ECD method ( Method AG 626). Following three applications of the WP formulation totaling 0.33 lb ai/ A, total propiconazole residues in/ on sugar beet roots ranged from < 0.05 0.42 ppm at 0 DAT and < 0.05 0.23 ppm at 21 DAT, and total residues in/ on tops ranged from 2.10 6.10 ppm at 0 DAT and 0.74 2.60 ppm at 21 DAT. There was no noticeable decline in residues in/ on roots between 0 to 21 DAT, but residues did decline in/ on tops from 0 to 21 DAT. Following three applications of the EC formulation totaling 0.33 lb ai/ A, total propiconazole residues in/ on sugar beet roots ranged from < 0.05 0.34 ppm at 0 DAT and 0.05 0.23 ppm at 21 DAT, and total residues in/ on tops were 2.70 8.0 ppm at DAT and 0.77 9.20 ppm at 21 DAT. Average residues in/ on sugar beet roots were similar for both formulations at both 0 and 21 DAT ( 0.13 0.15 ppm), and average residues in/ on sugar beet tops were similar at 0 DAT for the WP ( 4.05 ppm) and EC ( 4.44 ppm) formulations. However, average residues in/ on tops at 21 DAT were considerably higher for the EC formulation ( 3.67 ppm) than for the WP formulation ( 1.67 ppm). This trend toward higher residues from the EC formulation at 21 DAT was evident in 3 out of the 4 field trials.

These data indicate that total propiconazole residues from the WP and EC formulations are similar in/ on sugar beet roots harvested at 0 or 21 DAT and in/ on sugar beet tops harvested at 0 DAT. However, by 21 days post treatment, residues in/ on tops were substantially higher for the EC formulation than for the WP formulation. Given the differences between the two types of formulations in residue levels on sugar beet tops at 21 DAT, a full set of field trials are required on tops in order to support the use of an EC formulation on sugar beets.

Bulb Vegetables Group Onion ( green and dry bulb). Field trial data on green and dry bulb onions have been previously reviewed ( DP Barcode D219664, L. Kutney, 6/ 14/ 96). In a total of 9 field trials conducted during 1993 in CA, CO, GA, ID, MI, OR, and TX, propiconazole ( 3.6 lb/ gal EC) was applied to green and dry bulb onions each as two broadcast foliar applications at 0.22 lb ai/ A/ application ( 1x rate, 7 tests) or 0.44 lb ai/ A/ application ( 2x rate, 2 tests), at RTIs of 7 days, for totals of 0.44 or 0.88 lb ai/ A ( 1x and 2x seasonal rates). Applications included the use of a surfactant at 0.25% v/ v. A single control and single ( 2x tests) or quadruplicate ( 1x tests) treated samples of green whole plants and dry bulb onions were collected at 14 DAT.

Samples were stored frozen from collection to analysis for up to 14 months, an interval supported by the available storage stability data. Total residues of propiconazole and its 2,4 DCBA containing metabolites in/ on green and dry bulb onions were determined using GC/ ECD Method AG 454B, which has a validated method LOQ of 0.05 ppm.

Following two broadcast applications of propiconazole ( EC) totaling 0.44 lb ai/ A ( 1x rate), residues were 0.57 7.50 ppm in/ on 28 samples of green onions harvested at 0 DAT and average residues were 2.4 ppm. In the two 2x rate tests, residues were 3.3 and 5.8 ppm in/ on the two samples of green onions at 0 DAT. For the dry bulb onions harvested at 14 DAT, residues were Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 26 of 63 < 0.05 0.18 ppm in/ on 28 samples from the 1x tests, with 19 samples having residues < LOQ. Average residues in/ on dry bulb onions were 0.05 ppm from the 1x tests. In the two 2x rate tests, residues were < 0.05 and 0.41 ppm in/ on the two samples of dry bulb onions at 14 DAT. The available onion data will support the proposed use pattern.

Leafy Vegetables ( except Brassica vegetables) Group Celery ( leaf petiole vegetables, subgroup 4B). In a series for celery field trials conducted in CA, FL, MI, NY, and TX ( PP# 8F3674, C. Deyrup, 12/ 14/ 88; and PP# 0F3869, W. Chin, 8/ 15/ 90), a 3.6 lb/ gal EC formulation of propiconazole was applied to celery during crop development as 4 or 5 broadcast foliar applications at 0.11 lb ai/ A/ application, at RTIs of 7 14 days, for a total of 0.44 0.55 lb ai/ A/ crop ( 1x 1.2x rate). In four tests, propiconazole ( EC) was also applied as 4 broadcast applications at 0.22 lb ai/ A, for a total of 0.88 lb ai/ A/ crop ( 2x rate). Applications were made using both aerial and ground equipment, and a sticker was included in the tank mix in selected trials. Samples of celery were harvested at 0, 7, and 14 DAT and stored frozen for up to 12 months prior to analysis. Total residues of propiconazole and its 2,4 DCBA metabolites were determined using GC/ ECD Method AG 454, which has an LOQ of 0.05 ppm.

Following applications totaling 0.44 0.55 lb ai/ A (~ 1x rate), total propiconazole residues were 0.27 4.98 ppm in/ on 20 samples of celery harvested at a PHI of 14 days. Median and average residues were 0.60 and 1.13 ppm, respectively, with a standard deviation of 1.28 ppm. Following applications totaling 0.88 lb ai/ A ( 2x rate), residues were 0.60 2.52 ppm in/ on 4 celery samples harvested at 14 DAT. Repeated samplings at 0, 7 and 14 indicated that residues declined at longer post treatment intervals.

Additional celery field trials were conducted in FL during 1994 ( 43655613. der) comparing sideby side applications of propiconazole formulated as a 45% WP and a 3.6 lb/ gal EC. Each formulation was applied four times to celery as broadcast foliar applications during crop development at 0.11 lb ai/ A/ application, at retreatment intervals ( RTIs) of 7 days, for a total of 0.44 lb ai/ A/ season. A single control and duplicate treated samples of whole immature plants were harvested from each plot at 0 days after the final application ( DAT), and single control and duplicate treated samples of mature untrimmed stalks ( RAC) were harvested from each plot at 14 DAT. Subsamples of trimmed stalks and trimmings were also collected at 14 DAT. Samples were stored frozen from collection to analysis for up to 9.5 months, an interval supported by available storage stability data. Residues of propiconazole and its 2,4 dichlorobenzoic acid ( DCBA) containing metabolites in/ on celery were determined using a GC/ ECD method ( Method AG 454B). Immediately following the final application ( 0 DAT), residues in/ on whole immature plants were 1.5 2.1 ppm for the EC formulation and 1.3 1.5 ppm for the WP formulation. At maturity ( 14 DAT), residues in/ on untrimmed stalks were 0.27 0.42 ppm for the EC formulation and 0.43 0.51 ppm for the WP formulation, with most of the residues being associated with the upper leaves. Residues in/ on trimmed stalks at 14 DAT were   0.05 ppm for the EC and 0.05 0.07 ppm for the WP, and residues in/ on trimmings were 0.41 0.45 ppm for the EC and 0.49 0.83 ppm for the WP. Average residues in/ on untrimmed stalks, trimmed stalks, and trimmings were 0.35, 0.04, and 0.43 ppm, respectively, for the EC formulation, and 0.47, 0.06, and 0.66 ppm, respectively, for the WP formulation. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 27 of 63 Although the data are limited, residues in/ on celery from the EC and WP formulations were similar in this trial. Considering both the original celery field trials and the side by side tests, adequate celery field trial data are available to support the proposed use on of propiconazole ( EC or WP) on leaf petiole vegetables.

Legume Vegetables Group Dried Shelled Beans and Peas, except soybean ( subgroup 6C). In conjunction with an earlier petition for use on legume vegetables, limited dry bean field trial data were submitted and reviewed under ( PP# 8F3674, C. Deyrup, 12/ 14/ 88). In a single field trial conducted in 1984, propiconazole ( 3.6 lb/ gal EC) was applied to dry beans as three broadcast foliar applications at 0.138 lb ai/ A/ application, for a total of 0.41 lb ai/ A/ season ( 1.2x rate). Duplicate treated samples of mature beans were collected at 25 DAT, and analyzed for combined propiconazole residues using GC/ ECD Method AG 454, which has an LOQ of 0.05 ppm. Combined residues in/ on beans were 0.14 and 0.08 ppm from the 1.2x rate.

Additional dry bean field trials from 1989 were later submitted and reviewed by the Agency ( DP Barcode D210266 and D210295, M. Rodriguez, 3/ 5/ 1997). In a series of 5 field trials conducted in ID, CO, ND, NE and MI, propiconazole ( 3.6 lb/ gal EC) was applied to dry bean varieties as three broadcast foliar applications at 0.138 lb ai/ A ( 5 tests) or 0.276 lb ai/ A ( 3 tests), for totals of 0.41 or 0.83 lb ai/ A/ season ( 1.2x and 2.5x rates). Samples of vines were collected from each trial at 7 DAT, and samples of hay and mature beans were collected at 23 31 DAT, with most hay and bean samples being collected around 28 DAT. Samples were stored frozen for up to 41 months prior to analysis. Combined residues of propiconazole and its 2,4 DCBA containing metabolites were determined using GC/ ECD Method AG 454B, which was adequately validated in conjunction with the analysis of field trial samples. The validated method LOQ is 0.05 ppm, and a LOD was not reported. Following three applications to dry beans at the 1.2x rate, combined propiconazole residues were 1.20 7.50 ppm in/ on 10 samples of vines at 7 DAT, 0.17 4.90 ppm in/ on 10 samples of hay at ~ 28 DAT, and < 0.05 0.13 ppm in/ on 10 samples of seeds at ~ 28 DAT. Average residues were 3.11 ppm for vines, 2.11 ppm for hay, and 0.08 ppm for seeds. Maximum residues from the 2.5x rate were 9.9, 15, and 0.10 ppm in/ on vines, hay and seeds, respectively.

Insufficient field trial data are available to support the purposed use of propiconazole on dry peas and beans as only six dry bean field trials are available and no dry pea field trials were conducted. For a subgroup crop tolerance on 6C, a total of 12 dry bean field trials and 5 dry pea field trials are required. In addition, the available dry bean field trials support a PHI of 28 days rather than the 14 day PHI on the proposed label.

Soybeans. Limited soybean residue data were originally submitted and reviewed under PP# 8F3674 ( C. Deyrup, 12/ 14/ 88), to support a use on legume vegetables. In these studies, propiconazole ( 3.6 lb/ gal EC) was applied to soybeans in 3 field trials as either: three applications at 0.14 lb ai/ A, totaling 0.41 lb ai/ A ( 1.2x rate); two applications at 0.16 lb ai/ A, totaling 0.33 lb ai/ A ( 1x rate); or three applications at 0.27 lb ai/ A, totaling 0.83 lb ai/ A ( 3.7x rate). Applications were made at RTIs of 3 31 days. Samples of hay were collected at 77 105 Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 28 of 63 DAT, and samples of seeds were collected at 64 105 DAT. All samples were analyzed for combined propiconazole residues using GC/ ECD Method AG 454, which has an LOQ of 0.05 ppm. Combined residues in/ on seeds were 0.15 0.41 ppm from the 1.2x rate, 0.10 0.43 ppm from the 1x rate, and 0.61 0.74 ppm from the 3.7x rate, and combined residues in/ on hay were 0.77 3.92 ppm from the 1.2x rate and 0.98 2.05 ppm from the 1x rate. Given the longer PHIs for hay and seed in these studies, these residue data are of limited value in assessing the currently proposed use pattern, which has much shorter PHIs.

More complete soybean field trial data were later submitted by Syngenta and reviewed by the Agency ( DP Barcode D210266 and D210295, M. Rodriguez, 3/ 5/ 1997. MRID 43386502). In a series of 14 field trials conducted throughout the U. S., propiconazole ( 3.6 lb/ gal EC) was applied to soybeans as two broadcast foliar applications at 0.165 lb ai/ A, at RTIs of ~ 21 days, for a total of 0.33 lb ai/ A/ season ( 1x rate). The first application was made at the beginning at pod formation ( Stage R3) and the second application was made at pod fill ( Stage R5). Duplicate treated samples of forage and hay were collected from each trial at 21 32 DAT, with most samples being collected around 30 DAT. Duplicate treated samples of beans and fodder were collected at 41 99 DAT, with most mature samples being collected around ~ 50 DAT. At two test sites, forage and hay were also collected at 0, 7, 14, 21 and 30 DAT, to examine residue decline. Samples were stored frozen for up to 41 months prior to analysis, an interval that is supported by the available storage stability data. Combined residues of propiconazole and its 2,4 DCBA containing metabolites in/ on soybean commodities were determined using GC/ ECD Method AG 454B, which was adequately validated in conjunction with the analysis of field trial samples. The validated method LOQ is 0.05 ppm, and a LOD was not reported. Following two applications at a 1x rate, combined propiconazole residues were 0.33 5.40 ppm in/ on forage and 0.48 21.0 ppm in/ on hay harvested at ~ 30 DAT, and residues averaged 2.42 ppm for forage and 4.78 ppm for hay. By ~ 50 DAT, combine residues were 0.06 0.80 ppm in/ on mature seeds and < 0.05 6.20 ppm in/ on fodder, and residues averaged 0.22 ppm in/ on seeds and 1.15 ppm in/ on fodder. [ Note: fodder residues are included here for informational purposes only, as soybean fodder ( straw) is no longer a regulated commodity]. Data from both residue decline trials indicate that residues in/ on forage and hay decrease at longer post treatment intervals.

A total of 20 soybean field trials were conducted during 2003 in EPA Regions 2, 4, and 5. ( 46576301. der). Each field trial included two treated plots, one for the harvest of forage and hay and the other for the harvest of seed. In the forage and hay plot, a multiple active ingredient EC formulation containing propiconazole at 1.04 lb ai/ gal was applied as three broadcast foliar applications beginning at early to mid flowering ( BBCH 60 65 or R1 R2) at 0.075 0.095 lb ai/ A/ application, at retreatment intervals ( RTIs) of 8 11 days, for totals of 0.24 0.25 lb ai/ A ( 0.75x). All applications were made using ground equipment and included the use of a non ionic surfactant at 0.125% v/ v. At each site, soybean forage and hay were harvested at 0 days after the last application ( DAT) and seeds were harvested at maturity, 19 24 DAT. At two field sites, forage and hay samples were also harvested at 3, ~ 5, ~ 7, and 10 DAT, and seeds were harvested at 18, 21, ~ 25, ~ 30, and ~ 32 DAT to examine residue decline. A single control and duplicate treated samples of each commodity were collected from each test at each interval. Samples were stored frozen from collection to analysis for up to 18 months, an interval supported by available storage stability data. Combined residues of propiconazole and its 2,4 dichlorobenzoic acid ( DCBA) containing metabolites in/ on soybean forage, hay and seeds were determined using an Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 29 of 63 adequate GC/ MSD method, which is a modification to Method AG 626. Although recoveries from forage and hay were low, averaging 65 68% at all fortification levels, the recoveries were very consistent with low standard deviations (  7%). Recoveries of propiconazole averaged 82% ( ± 6 15%) from seed. Therefore, the method is deemed adequate for data collection. Combined propiconazole residues ranged from 1.70 12.0 ppm in/ on forage and 2.63 27 ppm in/ on hay at 0 DAT, and averaged 4.9 ppm in/ on forage and 12.7 ppm in/ on hay. For mature seeds harvested at 19 24 DAT, combined residues ranged from < 0.1 0.27 ppm and averaged 0.09 ppm. The highest average field trial ( HAFT) residues were 8.43 ppm for forage, 26.4 ppm for hay, and 0.21 ppm for seeds. Data from the two residue decline trials indicate that combined residues declined slowly in forage and hay from 0 to 10 DAT, but remained relatively steady in seeds from 18 to 33 DAT. Since these field trials were conducted at 0.75x the maximum rate, the residue data were not used in the tolerance calculation.

To support a proposed later application timing on soybeans ( up to Stage R6), Syngenta also recently submitted data from four soybean field trials conducted in IL, IN and MS during 2003 ( 46473001. der). In these trials, propiconazole ( 3.6 lb/ gal EC) was applied to soybeans as lateseason broadcast foliar applications during pod and seed development. Each field site compared three different application regimes for propiconazole: ( 1) three applications at 0.11 0.12 lb ai/ A from BBCH Stages 71 to 89, for totals of 0.32 0.35 lb ai/ A/ season ( 1x rate); ( 2) two applications at 0.10 0.12 lb ai/ A at BBCH stages 77 to 89, for totals of 0.23 0.24 lb ai/ A/ season ( 0.67x rate); and ( 3) two applications at 0.17 0.19 lb ai/ A, at BBCH stages 77 to 89 for totals of 0.33 0.36 lb ai/ A/ season ( 1x rate). The BBCH growth stages of 71 89 are equivalent to Stages R4 R8. All applications were made using ground equipment at RTIs of 13 18 days, and did not include the use of any adjuvants. Single control and duplicate treated samples of soybean seed were harvested from each test at 30 DAT, and forage and hay samples were not collected. Soybean seed samples were stored frozen for up to 8.5 months prior to extraction for analysis. Combined residues of propiconazole and its 2,4 DCBA containing metabolites in/ on soybean seeds were determined using GC/ ECD Method AG 626, which was adequately validated in conjunction with the analysis of field trial samples. The validated method LOQ is 0.05 ppm, and a LOD was not reported. Following the two applications totaling 0.33 0.36 lb ai/ A ( 1x rate), combined residues levels in soybean seeds were 0.17 0.94 ppm and averaged 0.39 ppm in/ on 8 samples at 30 DAT. No residue decline trials were conducted.

Considering all the available soybean field trial data, HED considers sufficient residue data are available to support tolerances on soybean forage and hay harvested 30 days following the second of two applications totaling 0.33 lb ai/ A ( 1x rate). Although the petitioner has requested tolerances for soybean forage and hay, the Agency notes that the currently proposed use directions for soybean prohibit the feeding or grazing for forage or hay. HED also considers sufficient residue data are available to support tolerances on soybean seed, even though the PHIs of the soybean seed data varies from 30 to 90 days, as long as the label states that " do not apply later than the R5 growth stage' or ` apply up to Stage R6", no additional field trials are required for soybean seeds.

Berries Crop Group Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 30 of 63 Bush and Cane Berries. Field trial data on blueberry, blackberry, and raspberry have been previously reviewed ( DP Barcode D219664, L. Kutney, 6/ 14/ 96). In a total of 9 field trials conducted during 1994 in ME, MI, NC, NJ, OR, and WA, propiconazole ( 3.6 lb/ gal EC) was applied to blueberries or cane berries as five foliar applications at 0.17 lb ai/ A/ application ( 1x rate, 6 tests) or 0.34 lb ai/ A/ application ( 2x rate, 3 tests), at unspecified RTIs, for totals of 0.85 or 1.7 lb ai/ A ( 1x and 2x seasonal rates). Applications were made in a minimum volume of 20 gal/ A, and included the use of a spreader/ sticker at 1% v/ v. A single control and single or duplicate treated samples of berries were collected at 30 DAT. Samples were stored frozen from collection to analysis for up to 5 months, and combined residues of propiconazole and its 2,4 DCBA containing metabolites were determined using GC/ ECD Method AG 454B, which was validated in conjunction with the analysis of field trial samples. The validated method LOQ is 0.05 ppm.

Following applications of propiconazole ( EC) totaling 0.85 lb ai/ A ( 1x rate), residues were 0.14 0.66 ppm in/ on 12 berry samples harvested at 30 DAT, and average residues were 0.36 ppm. In the three tests conducted at a 2x rate ( 1.7 lb ai/ A), residues were 0.27 0.98 ppm in/ on 4 samples from 30 DAT, and averaged 0.49 ppm. These field trial data will support the proposed use on bush and cane berries.

Cranberry. The available cranberry data are discussed here under the berry crop group, although cranberry has not yet been officially placed in the expanded berries crop group. A total of three cranberry field trials were conducted, including two in WI during 1995 and one in OR during 1999 ( 45778901. der and 44338101. der). In each test, propiconazole ( 3.6 lb/ gal EC) was applied to established fields of cranberries as four broadcast foliar applications at 0.156 0.170 lb ai/ A/ application, for a total of 0.66 0.68 lb ai/ A/ season. The first two applications were made at bud break and at ~ 14 days after bud break, and the final two applications were made during fruit development. Retreatment intervals ( RTIs) were 13 14 days between the first and second applications, 45 56 days between the second and third applications, and 11 14 days or 78 days between the third and fourth applications. No adjuvants were included in the spray mixes, and all application were made using ground equipment in 18 80 gal/ A. One to four control samples and duplicate treated samples of cranberries were harvested from each site at 43 or 44 days after the final application ( DAT). Samples were stored frozen from collection to analysis for up to 78 days. This interval is supported by the concurrent storage study indicating that propiconazole is stable at  20 º C in cranberries for up to 92 days. The combined residues of propiconazole and its 2,4 dichlorobenzoic acid ( DCBA) containing metabolites in/ on cranberries were determined using either a GC/ NPD method ( Method AG 454B, modified) for the 1995 tests or a GC/ ECD method ( Method AAG 626) for the 1999 test. These methods are updated versions of the current tolerance enforcement method. The validated method limit of quantitation ( LOQ) is 0.05 ppm, and a limit of detection ( LOD) was not reported. Control samples of cranberries were fortified with propiconazole at 0.05, 0.50, and 1.0 ppm and recoveries at each level averaged 74 96%, with standard deviations range from 2 25 %.

Following four applications of propiconazole ( EC) totaling 0.66 0.68 lb ai/ A, residues were 0.18 0.59 ppm in/ on 6 cranberry samples harvested 43 44 DAT, and averaged 0.32 ppm. A residue decline trial was not conducted. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 31 of 63 These field trial data support the use of propiconazole ( EC) on cranberries with up to four applications at 0.169 lb ai/ A/ application, for a total of 0.68 lb ai/ A/ season, minimum RTIs of 14 days and a PHI of 45 days. These data are adequate to support the proposed use on cranberries, restricted to WI and the Pacific NW.

Strawberry. Although strawberry has not yet been officially placed in the expanded berries crop group, the available strawberry data are discussed here under the berry crop group. In 8 field trials conducted throughout the U. S. in 1996 ( 45542401. der), propiconazole ( 3.6 lb/ gal) was applied to strawberries as four broadcast foliar applications during fruit development at 0.11 lb ai/ A/ application at retreatment intervals ( RTIs) of 6 8 days, for a total of 0.44 lb ai/ A/ season. All applications were made using ground equipment at volumes of 50 100 gal/ A, and no adjuvants were used. Single control and duplicate treated samples of strawberries were harvested from each site on the same day as the final application ( 0 DAT) and at 3 or 8 DAT at two sites. Samples were stored frozen from collection to analysis for up to 18 months, an interval supported by available storage stability data. Combined residues of propiconazole and its 2,4 dichlorobenzoic acid ( DCBA) containing metabolites in/ on strawberries were determined using an adequate GC/ ECD method ( Method AG 45B). The validated method limit of quantitation ( LOQ) is 0.05 ppm, and the limit of detection ( LOD) was not reported. The concurrent recovery of propiconazole averaged 77 ± 8% from control samples fortified at 0.05 or 0.50 ppm. Although the raw data ( instead of corrected data) were used to report residue values, the data collection method detects parent plus all metabolites containing DCBA, and yet the Agency's tolerance expression for propiconazole will be established at parent only, there fore, tolerances will not under represent the real residue levels.

Following the last of four foliar applications totaling 0.44 lb ai/ A, total uncorrected propiconazole residues were 0.07 0.69 ppm in/ on 16 samples of strawberries harvested on the day of the final application ( 0 DAT). Average residues were 0.35 ppm and the highest average field trial ( HAFT) residues were 0.60 ppm. Data from both residue decline tests indicated that residues declined on strawberries at longer post treatment intervals.

The number of trials and the geographic representation of the trials are adequate. These data will support the use of propiconazole ( EC) on strawberries as up four broadcast foliar applications at 0.11 lb ai/ A/ application, at a minimum RTI of 7 days, for a total of 0.44 lb ai/ A/ season, with a 0 day PHI.

Tree Nuts Crop Group Pecan. Adequate field trial data on pecans were submitted in conjunction with an earlier petition for use of propiconazole on pecans. ( PP# 4F3007, A. Smith, 5/ 15/ 84). In eight field trials conducted in AL, OK, GA, LA, TX, and NM, propiconazole, formulated as a 3.6 lb/ gal EC, was applied to pecans as 6 10 foliar applications at 0.33 lb ai/ A/ application, beginning a bud break and continuing at 2 week intervals until shuck split. All tests were conducted using ground equipment, and total application rates were 2 3.3 lb ai/ A/ season ( 2 3x rate). Residues in/ on all samples of pecan nutmeats were below the method LOQs (< 0.05 or < 0.1 ppm). Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 32 of 63 Almond. In five field trials conducted during 1998 and 1999 in CA, propiconazole was applied to almonds in side by side tests comparing the use of 45% WP and 3.6 lb/ gal EC formulations. Applications were made as dilute sprays ( 160 207 gal/ A) at two sites, as concentrated sprays ( 10 gal/ A) at two sites, and as both dilute ( 150 gal/ A) and concentrated ( 75 gal/ A) sprays at the fifth site. In each test, propiconazole ( EC or WP) was applied four times to almonds as foliar applications during nut development at 0.22 0.25 lb ai/ A/ application, at retreatment intervals ( RTIs) of 6 14 days, for a total of 0.88 0.91 lb ai/ A/ season. All applications were made using ground equipment and adjuvants were not added to the spray mix. Single control and duplicate treated samples of nutmeats and hulls were collected from each test at normal maturity, 53 63 days after the final application ( DAT). In one test, duplicate treated samples of nutmeats and hulls were collected at 40, 49, 55, 63, and 68 DAT to examined residue decline. Samples were stored frozen from collection to analysis for up to 10 months, an interval supported by available storage stability data.

Combined residues of propiconazole and its 2,4 dichlorobenzoic acid ( DCBA) containing metabolites in/ on almond nutmeats and hulls were determined using adequate GC/ ECD methods ( Methods AG 454B and AG 626). The validated method LOQ is 0.05 ppm for nutmeats and 0.10 ppm for hulls, and a LOD was not reported. Although the concurrent recoveries from nutmeat and hulls were generally low ( 60 80%), the recoveries were relatively consistent. Therefore, the method is deemed adequate for data collection. Although the raw data ( instead of corrected data) were used to report residue values, the data collection method detects parent plus all metabolites containing DCBA, and yet the Agency's tolerance expression for propiconazole will be established at parent only, there fore, tolerances will not under represent the real residue levels.

Application volume and formulation type had no apparent effect on residue levels. For samples treated with the WP, combined residues range from < 0.05 0.07 ppm in/ on 12 samples of nutmeats and 0.57 4.60 ppm in/ on 12 samples of hulls, For samples treated with the EC formulation , combined residues range from < 0.05 0.09 ppm in/ on 12 samples of nutmeats and 0.85 4.20 ppm in/ on 12 samples of hulls. For the WP and EC formulations, average residues were respectively 0.035 and 0.041 ppm in/ on nutmeats and 1.78 and 2.06 ppm in/ on hulls. When data from both formulations are pooled, average residues are 0.038 ppm in/ on nutmeats and 1.92 ppm in/ on hulls.

In the residue decline test, residues in/ on nutmeats declined slightly from an average of 0.07 ppm at 40 DAT to < 0.05 ppm by 68 DAT. However, residue levels in/ on hulls were variable over time. Given the variability of residues in/ on hulls at a single sampling interval ( 1.92 ± 1.20 ppm; 53 63 DAT), the decline data most likely represent the variability in hulls residues rather than any trend in hull residue levels.

The number of trials and the geographic representation of the trials are adequate. These data will support the use of propiconazole ( EC or WP) on almonds as up four foliar applications during nut development at 0.22 lb ai/ A/ application, at a minimum RTI of 7 days, for a total of 0.88 lb ai/ A/ season, with a 60 day PHI. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 33 of 63 Together the pecan and almond field trial data are sufficient to support the proposed uses on various members of the tree nut crop group.

Cereal Grains and Forage, Fodder, and Straw of Cereal Grains Groups Corn ( field, pop and sweet). Propiconazole ( EC and WP) is currently registered for use on field, pop, and sweet corn as multiple foliar applications through silking at up to 0.11 lb ai/ A/ application, at minimum RTIs of 7 days, for a total of 0.44 lb ai/ A/ season. Labeled PHIs are 14 days for sweet corn ears and forage, and 30 days for field corn forage. No PHI is specified for mature field, pop or seed corn.

Residue data on field and sweet corn supporting the original use pattern were reviewed under PP# 8F3674 ( C. Deyrup, 12/ 14/ 88). In these studies, propiconazole ( 3.6 lb/ gal EC) was applied to field or sweet corn in 14 tests as five broadcast foliar applications at 0.055 0.11 lb ai/ A, for a total of 0.39 lb ai/ A/ season (~ 0.9x rate), and in 3 tests as 5 8 foliar applications at 0.055 0.11 lb ai/ A, for a total of 0.44 lb ai/ A/ season ( 1x rate). Seven trials were also conducted using exaggerate applications at 0.11 0.22 lb ai/ A, for totals of 0.77 0.88 lb ai/ A/ season ( 1.8 2x rates). In the sweet corn trials, samples of ears and forage were harvested from all tests at 14 38 DAT. In the field corn trials, forage samples were collected at 21 43 DAT, fodder samples were collected at 57 78 DAT, and grain samples were collected at 21 78 DAT. All samples were analyzed for combined propiconazole residues using GC/ ECD Method AG 454, which has an LOQ of 0.05 ppm.

In the sweet corn tests conducted at 0.9x and 1.8x rates, combined residues were < 0.05 0.06 ppm in/ on K+ CWHR and 1.27 5.00 ppm in/ on forage; maximum forage residues were found at 14 DAT from a 0.9x rate test. In the field corn tests conducted at 0.9 1x rates, combined residues were 0.12 9.30 ppm in/ on forage, < 0.05 ppm in/ on grain, 0.16 4.12 ppm in/ on fodder ( stover). In the field corn tests conducted at 1.8 2x rates, combined residues were 1.36 14.6 ppm in/ on forage, < 0.05 0.06 ppm in/ on grain, 0.67 8.02 ppm in/ on fodder ( stover). Based on these data, temporary tolerances have been established at 0.1 ppm in/ on corn, field, grain and corn, sweet, K+ CWHR, and at 12 ppm in/ on corn, field, forage and stover. The 12 ppm tolerance for field corn forage was set at 12 ppm because the maximum residues in field corn forage ( 9.3 ppm) were observed from a test conducted at 0.9x rate; therefore, the maximum expected residues were assumed to be 10.3 ppm. These tolerances are set to expire on 11/ 30/ 08.

43655612. der In addition to the above corn data, Syngenta has also submitted data from side by side tests conducted during 1994 on field and sweet corn ( 43655612. der), comparing residues resulting from the use of EC and WP formulations. Two tests each were conducted on field and sweet corn. In each test, propiconazole ( EC or WP) was applied four times prior to silking as broadcast foliar applications at 0.11 lb ai/ A/ application, at RTIs of 5 9 days, for a total of 0.44 lb ai/ A/ season ( 1x rate). In the field corn tests, samples of forage were collected at 30 31 DAT and 56 63 DAT, and grain and stover were collected at 93 or 118 DAT. In the sweet corn tests, samples of forage were collected at 14 DAT, and samples of mature forage and K+ CWHR were collected at 25 35 DAT. All samples were analyzed for combined propiconazole residues using GC/ ECD Method AG 454B, which has an LOQ of 0.05 ppm. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 34 of 63 In the side by side tests, combined residues in/ on the various corn commodities were similar for the two formulations. For field corn treated with the EC, residues averaged 0.60 ± 0.67 ppm for forage at ~ 30 DAT and 0.98 ± 1.11 ppm for mature stover. For the WP formulation, combined residues averaged 0.74 ± 0.81 ppm for forage at ~ 30 DAT and 1.20 ± 1.34 ppm for mature stover. Combined residues were < LOQ in/ on all samples of corn grain, regardless of the formulation used. For sweet corn treated with the EC, residues averaged 0.23 ± 0.15 ppm for forage at 14 DAT and 0.45 ± 0.48 ppm for mature forage. For the WP formulation, residues averaged 0.22 ± 0.10 ppm for forage at 14 DAT and 0.43 ± 0.43 ppm for mature forage. Combined residues were < LOQ in/ on all samples of sweet corn ears ( K+ CWHR) for both formulations.

In the current petition, the maximum single and seasonal use rate on corn are unchanged, but Syngenta is now proposing to allow applications to field, seed and pop corn later in the season, during grain development, and establishing at 30 day PHI for grain and stover of field, pop, and seed corn. Residue data reflecting this later use pattern are described below; no new residue data on sweet corn have been submitted.

45080809 and 45080810. der In a total of 28 field trials conducted throughout the U. S. during 1998 and 1999, propiconazole ( 1.04 lb/ gal EC) was applied to field corn ( 24 trials) and popcorn ( 4 trials). With a few exceptions, each field corn trial included one treated plot for the collection of forage and another plot for the collection of grain and stover, and the four popcorn field trials each had a single treated plot for the collection of only grain and stover. Propiconazole ( EC) was applied to the forage plots as two broadcast foliar applications during early vegetative development at a rate of 0.11 lb ai/ A/ application, for a total of 0.22 lb ai/ A. The retreatment interval ( RTI) for the forage applications ranged from 3 8 days, but was typically 7 days. For the grain and stover plots, propiconazole ( EC) was applied to the corn as four broadcast foliar applications from flowering through grain development at rates of 0.09 0.14 lb ai/ A/ application, for a total of 0.42 0.47 lb ai/ A. The RTIs ranged from 6 9 days, but were typically 7 days. All applications were made using ground equipment in volumes of 5 25 gal/ A, and no adjuvants were included in the spray mixtures. At two of the field corn sites, propiconazole was also applied as four broadcast foliar applications during grain development at 0.55 lb ai/ A/ application, for a total of 2.2 lb ai/ A ( 5x rate). In four of the 1998 field trials, propiconazole was misapplied to the forage and/ or stover and grain plots at a reduced rate ( 0.05 0.06 lb ai/ A/ application); these field trials were replaced by the subsequent 1999 field trials.

Single control and duplicate treated samples of forage were harvested at 29 32 days after the last treatment ( DAT), except in three tests in which forage was collected at 15, 51 or 67 DAT. Single control and duplicate treated samples of corn stover and grain were harvested at 28 35 DAT from all tests, with most samples being collected at 29 30 DAT. To examine residue decline, repeated control and treated samples were also collected at two sites at 0, 9, 16, 23, 30 and 36/ 37 DAT for forage and stover and at 9, 16, 23, 30 and 36 DAT for grain. Samples were stored frozen from collection to analysis for up to 15.9 months, an interval supported by available storage stability data. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 35 of 63 Combined residues of propiconazole and its 2,4 dichlorobenzoic acid ( DCBA) containing metabolites in/ on corn forage, grain and stover were determined using adequate GC/ ECD methods ( Methods AG 454B and AG 626). The validated method limit of quantitation ( LOQ) is 0.05 ppm, and the limit of detection ( LOD) was not reported. Concurrent recoveries of propiconazole averaged 93 ± 11% from forage, 89 ± 13 % from stover and 90 ± 15% from grain.

Following the two early season broadcast foliar applications totaling 0.22 lb ai/ A, combined propiconazole residues range from < 0.05 1.90 ppm and averaged 0.45 ppm in/ on 36 samples of forage harvested at 29 32 DAT. Following the four broadcast foliar applications during flowering through grain development at rates totaling 0.42 0.47 lb ai/ A, combined residues range from 0.92 19.6 ppm in/ on 48 samples of stover and < 0.05 0.15 ppm in/ on 48 samples of grain harvested at 28 35 DAT. Average residues were 6.87 in/ on stover and 0.037 ppm in/ on grain, and the highest average field trial ( HAFT) residues were 15.9 ppm in/ on stover and 0.10 ppm in/ on grain. In the two 5x rate tests, combined residues were 23.2 77 ppm in/ on four samples of stover and < 0.05 0.062 ppm in/ on four samples of grain harvested at 29 30 DAT. Data from the two residue decline trials indicated that residues in/ on forage and stover decreased at longer posttreatment intervals. However, residue decline could not be determined in grain as residues in grain were < LOQ in all but two samples from the declined trials.

The number of trials and geographic representation of the trials are adequate. These data support the use of up to four broadcast foliar applications of propiconazole ( EC) to field or pop corn through grain development, up to the dent stage ( R5 stage), at 0.11 lb ai/ A/ application, at a minimum RTI of 7 days, for a total of 0.44 lb ai/ A/ season. The data also support a PHI of 30 days for harvest of forage, grain and stover. However, these most recent data will only support the use of two early season applications prior to the harvest of forage. If the petitioner intends to support total use rates of 0.22 lb ai/ A to field corn prior to the harvest of forage, then the current residue data on forage indicate that the tolerance for field corn forage could be reduced from 12 ppm to 4.5 ppm.

Rice. The Agency recently reviewed ( DP Barcode D240856, T. Morton, 2/ 23/ 05) residue data from eight rice field trials conducted in 1996 reflecting the use of propiconazole ( 3.6 lb/ gal EC) as either a single broadcast foliar application during internode elongation at 0.28 lb ai/ A ( 4 tests) or as a split application at 0.17 lb ai/ A/ application during internode elongation and again at booting, for a total of 0.34 lb ai/ A ( 4 tests). Combined propiconazole residues were < 0.05 0.28 ppm in/ on grain and 0.50 1.75 ppm in/ on straw at 45 days following the single application at 0.28 lb ai/ A, and < 0.05 0.07 ppm in/ on grain and 0.33 1.62 ppm in/ on straw at 45 days following the second of the two split applications.

45080811. der For the current petition, Syngenta is now proposing that the single or split applications of propiconazole be allowed later in the season, at up to heading. To support this use, Syngenta submitted 16 new rice field trials conducted during 1998 in the major rice producing areas of the U. S. ( 45080811. der). At each site, propiconazole ( 3.6 lb/ gal EC) was applied to rice as a single broadcast foliar application at 0.28 lb ai/ A during heading ( 1x rate). Four of the trial sites also included another treatment, in which propiconazole ( 1.04 lb/ gal EC) was applied as split broadcast foliar applications around heading at 0.154 lb ai/ A/ application, at retreatment intervals ( RTIs) of 14 days, for a total of 0.31 lb ai/ A/ season. Single control and duplicate treated samples Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 36 of 63 of rice straw and grain were harvested from each site at 34 49 days after treatment ( DAT), with 14 sites having harvest intervals of 34 37 days. To examine residue decline, additional samples were collected from two test sites at 14, 21, 27 28, 34 38, and 42 45 DAT. Samples were stored frozen from collection to analysis for up to 11.2 months, an interval supported by the available storage stability data.

Combined residues of propiconazole and its 2,4 dichlorobenzoic acid ( DCBA) containing metabolites in/ on rice grain and straw were determined using an adequate GC/ ECD method ( Method AG 626). Concurrent recoveries from rice straw showed averaged 91 ± 13% and from rice grain 91 ± 7%. The validated method LOQ is 0.05 ppm, and an LOD was not reported.

Following a single application of propiconazole ( EC) at 0.28 lb ai/ A ( 1x rate), total propiconazole residues ranged from 0.97 17.0 ppm in/ on 32 samples of straw and 0.03 6.50 ppm in/ on 32 samples of grain harvested at 34 49 DAT. Average residues were 4.50 ppm for straw and 1.76 ppm for grain. At the four sites where the single application at 0.28 lb ai/ A was compared to the split application totaling 0.31 lb ai/ A, residues were similar between the two treatments. Average residues in/ on grain and straw were 1.34 and 4.27 ppm, respectively, following the single application, and 1.17 and 4.04 ppm, respectively, following the two split applications.

In the two residue decline tests, residues in/ on rice grain remained relatively steadily over time, averaging 1.45 ppm at 14 DAT and 1.22 ppm at ~ 45 DAT. Residues in/ on straw showed a slight increase at longer post treatment intervals, but the trend could not be verified due to the variability in the residue data on straw. Average residues in/ on straw were 3.05 ppm at 14 DAT and 4.45 ppm by ~ 45 DAT. The slight increase in straw residues may be the result of drying down of the foliage as the crop matures. The most recent rice field trials adequate support the proposed 35 day PHI and a minimum RTI of 14 days for the split applications.

Sorghum. Propiconazole ( 3.6 lb/ gal EC) was applied to sorghum in 12 field trials conducted during 1998 ( 45275801. der). The number of trials and the geographic representation of the trials are adequate. At each field site, separate plots were established for the collection of forage or grain and stover. For the forage plots, propiconazole was applied as two broadcast foliar applications beginning around flower initiation at 0.11 lb ai/ A/ application, at a retreatment interval ( RTI) of 5 days, for a total of 0.22 lb ai/ A/ season ( 0.5x seasonal rate). In the grain/ stover plots, propiconazole was applied as four broadcast foliar applications at 0.11 lb ai/ A/ application, beginning at flowering or early grain development, for a total of 0.44 lb ai/ A/ season. Two test sites also included separate grain/ stover plots treated at exaggerated rates of 0.33 or 0.55 lb ai/ A/ application, for a total of 1.32 or 2.20 lb ai/ A/ season ( reported as 3x and 5x rates). The RTIs for the grain/ stover plots ranged from 3 11 days, but were 4 5 days at most test sites. Single control and duplicate treated samples were collected from each plot, with forage samples being harvested at 0 and 29 31 days after the final treatment ( DAT) and grain and stover samples being harvested 18 22 DAT. Repeated samples were also collected at two sites to examine residue decline, with forage being sampled at 0, 9, 16, 23, 30 and 37/ 38 DAT, and grain and stover being sampled at 0, 7, 14, 21 and 28 DAT. Samples were stored frozen for up to 17.1 months prior to extraction for analysis. Adequate storage stability data are available to support the storage intervals and conditions for the current sorghum field trials. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 37 of 63 Combined residues of propiconazole and its 2,4 dichlorobenzoic acid ( DCBA) containing metabolites in/ on sorghum forage, stover and grain were determined using an adequate GC/ ECD method ( Method AG 626, modified), which was adequately validated in conjunction with the analysis of field trial samples. The validated method limit of quantitation ( LOQ) is 0.05 ppm, and the limit of detection ( LOD) was not reported.

Following two applications totaling 0.22 lb ai/ A ( 0.5x rate),, combined residues in/ on forage were 1.80 11.6 ppm in/ on 14 samples at 0 DAT and 1.5 8.2 ppm in/ on 24 samples at 29 31 DAT, and average residues in/ on forage were 6.3 ppm at 0 DAT and 4.4 ppm at 29 31 DAT. Following four applications totaling 0.44 lb ai/ A( 1x rate), residues were 2.8 11.7 in/ on 24 samples of stover and 0.52 2.30 ppm in/ on 24 samples of grain harvested at 18 22 DAT, and average residues were 5.8 ppm in/ on stover and 1.14 ppm in/ on grain. In the exaggerated rate test at 1.32 lb ai/ A ( 3x rate), residues were 12.6 and 15.0 ppm in/ on stover and 4.7 and 4.8 ppm in/ on grain at 18 DAT. In the two exaggerated rate tests at 2.20 lb ai/ A ( 5x rate), residues were 7.4 30.6 ppm in/ on stover and 2.1 7.1 ppm in/ on grain at 18 20 DAT.

Data from the two residue decline field trials showed a slight downward trend in residue levels in all three commodities over time, but the decline was erratic in forage and stover and there was a substantial degree of variability in residue levels at each interval. The Agency notes that the combined residues in forage, stover and grain in one of the decline trials were actually higher than the maximum residues observed around the earlier PHI. Maximum residues in forage were 8.2 ppm at 29 31 DAT and 8.3 ppm at 37 38 DAT; maximum residues in stover were 11.7 ppm at 18 22 DAT and 14.2 ppm at 28 DAT; and maximum residues in grain were 2.3 ppm at 18 22 DAT and 2.4 ppm at 28 DAT. As residue levels at these later intervals were equivalent or higher than residues observed around the proposed PHIs, residue values from these sampling intervals will be included in the data base used for calculating sorghum tolerances.

The sorghum field trial data are adequate and support the proposed use pattern, provided that the label is amended to specify a maximum total application rate of 0.22 lb ai/ A on sorghum harvested for forage.

Wheat. Previously reviewed residue data and use directions for propiconazole on wheat have allowed for a single application up to heading ( Feekes Growth Stage 10.5) at 0.11 lb ai/ A. In the current petition, Syngenta is now proposing increasing the use rates for wheat ( and barley, rye, triticale, and oats) to include up to two applications at 0.11 lb ai/ A up to heading, with a minimum RTI of 14 days. In evaluating the proposed use, this review will only consider the wheat field trial data including the two applications use pattern.

The Agency recently reviewed ( DP Barcode D240856, T. Morton, 2/ 23/ 05) residue data from 12 wheat field trials conducted in 1992 93 reflecting the use of propiconazole ( 3.6 lb/ gal EC) as two broadcast foliar applications at 0.11 lb ai/ A, at Feekes Growth 5 and 8, for a total of 0.22 lb ai/ A/ season ( 1x rate). Retreatment intervals were 6 31 days and all applications were made using ground equipment. Single control and duplicate treated samples of wheat forage were harvested from each site 0 and 30 32 DAT, and mature wheat grain and straw were harvested at 54 91 DAT. Wheat hay was not sampled. Samples were stored frozen from collection to Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 38 of 63 analysis for up to 19 months, an interval supported by available storage stability data. Combined residues were determined using GC/ ECD Method AG 454B, which was adequately validated in conjunction with the analysis for field trial samples. The validated LOQ is 0.05 ppm, and the LOD was not reported Following two applications totaling 0.22 lb ai/ A ( 1x rate), combined residues in/ on wheat forage harvested at 0 and 30 32 DAT were < 1.2 10.7 ppm and 0.09 1.7 ppm, respectively. Combined residues in/ on wheat grain and straw harvested at 54 91 DAT < 0.05 0.08 ppm and < 0.05 4.2 ppm, respectively. Average combined residues were 4.37 ppm in/ on forage at 0 DAT, 0.70 ppm in/ on forage at ~ 30 DAT ( proposed PHI), 0.98 ppm in/ on straw, and 0.03 ppm in/ on grain. These field trial data do not adequately support the currently proposed use on wheat as only 12 of the required 20 field trials were conducted, no hay samples were collected, the applications were made earlier in the season ( Feekes 5 and 8). However, the forage residue data from the 30 DAT samples do reflect two applications to forage, although the number of tests is insufficient to support a forage tolerance.

More recently, Syngenta has submitted additional wheat field trials more in line with the requested use pattern on wheat ( 44757208. der1). In a total of 21 field trials conducted throughout the U. S. during 1997, propiconazole ( 3.6 lb/ gal EC) was applied to at least three separate plots of wheat at each site. In two plots at each site, propiconazole was applied as a single broadcast foliar application at 0.11 0.12 lb ai/ A ( 0.5x rate) at either Feekes Growth Stage 5 or FGS 10.5. The early season application at FGS 5 was used for the collection of forage and hay, and the late season application at FGS 10.5 was used for collection of grain and straw. In the third plot, propiconazole was applied as two late season, broadcast foliar applications at booting and heading ( Feekes Growth Stages 10 and 10.5), at 0.11 0.12 lb ai/ A/ application, for a total of 0.22 0.23 lb ai/ A ( 1x rate). This plot was used for the collection of grain and straw samples. All applications were made using ground equipment at spray volumes of 11 25 gal/ A, and no adjuvants were included in the tank mixtures. For the plots that received two applications, the RTI was 13 22 days, with most tests having a RTI of 14 days.

Single control and duplicate treated samples of forage were harvested at 29 32 DAT, and hay samples were cut at 43 50 DAT, with most hay samples being cut at 45 DAT. Single control and duplicate treated samples of mature wheat grain and straw were harvested at 27 50 DAT, with most samples being collected around 40 DAT. To examine residue decline, repeated control and treated samples were collected at two sites from 0 37 DAT for forage, 29 59 DAT for hay, and 21 73 DAT for grain and straw. Samples were stored frozen from collection to analysis for up to 16.3 months, an interval supported by available storage stability data.

Combined residues of propiconazole and its 2,4 DCBA containing metabolites were determined using GC/ ECD Method AG 454 B, which was adequately validated in conjunction with the analysis of field trial samples. The validated method LOQ is 0.05 ppm for each wheat commodity, but the LOD was not reported. Samples were also analyzed for residues of propiconazole, per se, using a GC/ NPD method from PAM Vol. I ( Method 302 E4 + DG5); this method was also adequately validated in conjunction with the analysis of field trial samples. The method LOQ for propiconazole was 0.05 ppm, and a LOD was not reported. Propiconazole Summary of Analyt ical Chemist ry and Residue Data Barcode D238458 Page 39 of 63 Following an application at Feekes Growth Stage 5 at 0.11 lb ai/ A ( 0.5x), total combined residues were < 0.05 1.91 ppm in/ on forage harvested at 29 32 DAT and < 0.05 1.10 ppm in/ on hay cut at 43 50 DAT, and average combined residues were 0.33 and 0.30 ppm in/ on forage and hay, respectively. Residues of parent propiconazole were < 0.05 0.49 ppm in/ on forage and < 0.05 0.20 ppm in/ on hay, and averaged 0.06 and 0.04 ppm, respectively.

Following a single application during heading at 0.11 0.12 lb ai/ A ( 0.5x), total combined residues were 0.41 6.21 ppm in/ on straw and < 0.05 0.13 ppm in/ on grain harvested at maturity, 27 57 DAT, and combined residues averaged 2.02 and 0.04 ppm in/ on straw and grain, respectively. Residues of parent propiconazole were < 0.05 1.63 ppm in/ on straw and < 0.05 ppm in/ on grain, and averaged 0.45 and 0.025 ppm, respectively.

Following two broadcast applications during booting and heading at total rates of 0.22 lb ai/ A ( 1x rate), total combined residues were 0.20 8.27 ppm in/ on straw and < 0.05 0.20 ppm in/ on grain harvested at 27 57 DAT. Combined residues averaged 3.31 and 0.07 ppm in/ on straw and grain, respectively. Residues of parent were < 0.05 3.49 ppm in/ on straw and   0.05 ppm in/ on grain, and averaged 0.73 and 0.025 ppm, respectively.

The most recent wheat data will support the proposed late season use pattern for wheat and the PHIs of 30 days for forage, 45 days for hay, and 40 days for grain and straw. Although these data support the use of applications totaling 0.22 lb ai/ A prior to harvest of mature grain, the data will only support the use of applications totaling 0.11 lb ai/ A, prior to the harvest of either forage or hay. Limited field trial data are available ( 12 tests) reflecting 1x applications to forage, but no data are available for hay reflecting the 1x rate. Therefore, the label should be amended to specify that only a total of 0.11 lb ai/ A may be applied prior to the harvest or grazing of forage and hay. If the petitioner intends to support the use of two applications at 1x prior to harvest of forage and hay, then an additional 8 field trials are required on forage and a complete set of 20 field trials would be required for hay.

Miscellaneous Commodities Mint. In five field trials conducted during 1995 in Regions 5 and 11 ( 44416501. der), propiconazole ( 3.6 lb/ gal EC) was applied twice to established fields of mint as broadcast foliar applications at 0.111 0.114 lb ai/ A/ application at RTIs of 13 14 days, for a total of 0.224 227 lb ai/ A/ season ( 1x rate). The initial application was made when plants were 4 8 inches in height, and all applications were made using ground equipment. Duplicate control and treated samples of fresh mint hay were harvested from each site at 29 30 DAT. Samples were stored frozen from collection to analysis for up to 62 days, an interval supported by available storage stability data. Total residues of propiconazole and its DCBA containing metabolites in/ on mint were determined using a GC/ ECD Method AG 454B, which was adequately validated in conjunction with the analysis of field trial samples. The validated method LOQ is 0.05 ppm, and an LOD was not reported.