based on weight of product	Not for use on food grade adhesives

	42182-1

	Incorporated into production of end use product	.1% - 1% a.i. based on
weight of finished product	Distributors of products containing the
additive may not make claims of antimicrobial activity other than the
protection of the product against the growth of bacteria, mold, mildew
and fungi in or on the treated product; Not for use on food grade
adhesives

Polymeric systems	10466-42	Incorporation into production of end-use
product	4%-1.5% based on weight of goods

10466-38	Incorporation into production of end-use product	0.05% - 3%
based on weight of goods; inclusive of synthetic fibers, molded plastics
and synthetic foams

	Vinyl Film: Garment Bags, Blanket Bags, Cubicle Curtains

	42182-1

	Incorporated into production of end use product	.1% - 1% a.i. based on
weight of finished product	Distributors of products containing the
additive may not make claims of antimicrobial activity other than the
protection of the product against the growth of bacteria, mold, mildew
and fungi in or on the treated product.

Polyethylene, Polypropylene, Vinyl, Nylon, Latex and products of similar
matrix

	5383-127

	Incorporated into production of end use product	0.5%-1.0% by weight of
the fabric	Distributors of products containing the additive may not make
claims of antimicrobial activity other than the protection of the
product against the growth of bacteria, mold, mildew and fungi in or on
the treated product.

Polypropylene, Nylon and Acrylic Fibers and blends of these fibers with
cotton	5383-127

	Incorporated into production of end use product	Incorporated at a
percent ranging from 0.1% to 1.5% by weight of the fabric 	Distributors
of products containing the additive may not make claims of antimicrobial
activity other than the protection of the product against the growth of
bacteria, mold, mildew and fungi in or on the treated product.

Industrial Materials: air filters, air filtration media, janitorial
supplies,  trays, wipes, respirator mask components, conveyor belts
42182-1

	Incorporated into production of end use product	.1% - 1% a.i. based on
weight of finished product	Distributors of products containing the
additive may not make claims of antimicrobial activity other than the
protection of the product against the growth of bacteria, mold, mildew
and fungi in or on the treated product.

Ice Making Equipment

	42182-1

	Incorporated into production of end use product	.1% - 1% a.i. based on
weight of finished product	Distributors of products containing the
additive may not make claims of antimicrobial activity other than the
protection of the product against the growth of bacteria, mold, mildew
and fungi in or on the treated product.

Sporting Goods: boating/marine equipment, exercise & gym equipment,
playground equipment	42182-1

	Incorporated into production of end use product	.1% - 1% a.i. based on
weight of finished product	Distributors of products containing the
additive may not make claims of antimicrobial activity other than the
protection of the product against the growth of bacteria, mold, mildew
and fungi in or on the treated product.

Technical Registration	70404-2

73951-1	For processing or manufacturing use only	N/A

  SEQ CHAPTER \h \r 1 Appendix B:  Triclosan (Case 2340)

Appendix B lists the generic (not product specific) data requirements
which support the re-registration of Triclosan.  These requirements
apply to Triclosan in all products, including data requirements for
which a technical grade active ingredient is the test substance.  The
data table is organized in the following formats:

1.	Data Requirement (Columns 1 and 2).  The data requirements are listed
by Guideline Number.  The first column lists the new Part 158 Guideline
numbers, and the second column lists the old Part 158 Guideline numbers.
Each Guideline Number has an associated test protocol set forth in the
Pesticide Assessment Guidance, which are available on the EPA website.

Guideline Description (Column 3). Identifies the guideline type.

3.	Use Pattern (Column 4).  This column indicates the standard
Antimicrobial Division use patterns categories for which the generic
(not product specific) data requirements apply. The number designations
are used in Appendix B.

	(1) Agricultural premises and equipment

	(2) Food handling/ storage establishments premises and equipment

	(3) Commercial, institutional and industrial premises and equipment

	(4) Residential and public access premises

	(5) Medical premises and equipment

	(6) Human water systems

	(7) Materials preservatives

	(8) Industrial processes and water systems

	(9) Antifouling coatings

	(10) Wood preservatives

	(11) Swimming pools

	(12) Aquatic areas

3.	Bibliographic Citation (Column 5).  If the Agency has data in its
files to support a specific generic Guideline requirement, this column
will identity each study by a “Master Record Identification (MRID)
number. The listed studies are considered “valid” and acceptable for
satisfying the Guideline requirement. Refer to the Bibliography appendix
for a complete citation of each study.

DATA REQUIREMENT	CITATION(S)

New Guideline Number	Old Guideline Number	Study Title	Use Pattern	MRID
Number

PRODUCT CHEMISTRY

830.1550	61-1	Product Identity and Composition	3,4,7	42027901

45358501

830.1600 830.1620

830.1650	61-2a	Starting Materials and Manufacturing Process	3,4,7
42027901

45358502

45487201

830.1670	61-2b	Formation of Impurities	3,4,7	42027901

42027902

43277802

45358503

45358504

830.1700	62-1	Preliminary Analysis	3,4,7	42027902

45358504

830.1750	62-2	Certification of Limits	3,4,7	42027901

43277802

43533901

45358503

45358505

830.1800	62-3   	Analytical Method	3,4,7	42027902

45358506

830.6302	63-2	Color	3,4,7	42027902

45358502

830.6303	63-3	Physical State	3,4,7	42027902

830.6304	63-4	Odor	3,4,7	42027902

830.7200	63-5	Melting Point	3,4,7	42027904

830.7220	63-6	Boiling Point	3,4,7	N/A

830.7300	63-7	Density	3,4,7	42027904

830.7840

830.7860	63-8	Solubility	3,4,7	42027904

47261401

47261403

47261404

47261406

47261407

830.7950	63-9	Vapor Pressure	3,4,7	42027904

47261403

47261404

47261406

47261407

830.7550

830.7560

830.7570	63-11	Partition Coefficient (Octanol/Water)	3,4,7	42027902

42027904

830.7000	63-12	pH	3,4,7	N/A

830.6313	63-13	Stability	3,4,7	42027902

43022601

43277801

ECOLOGICAL EFFECTS

850.2100	71-1	Avian Acute Oral Toxicity Test, Bobwhite Quail	3,4,7
41008910

Avian Acute Oral Toxicity Test, Bobwhite Quail

43022602

Avian Acute Oral Toxicity Test, Mallard Duck

43022603

850.2200	71-2	Avian Dietary Toxicity Test, Bobwhite Quail	3,4,7	41008911

43022604

850.1075	72-1	Fish Acute Toxicity – Freshwater, Rainbow Trout	3,4,7
41008912

43969301

Fish Acute Toxicity – Freshwater, Bluegill Sunfish

41008913

850.1075	72-1	Estuarine/Marine – Fish Acute Toxicity 	3,4,7	Study
being held in reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.1010	72-2	Aquatic Invertebrate Acute Toxicity, Daphnia	3,4,7	Study
being held in reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.1025	72-3	Oyster acute toxicity test (shell deposition)	3,4,7	Study
being held in reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.1035	72-3	Mysid acute toxicity test	3,4,7	Study being held in
reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.1300	72-4	Daphnia Chronic Toxicity Test	3,4,7	Study being held in
reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.1400	72-4	Fish early-life stage toxicity test	3,4,7	Study being held
in reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.1500	72-5	Fish life cycle toxicity	3,4,7	Study being held in reserve
pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.1710	72-6	Oyster bioconcentration study 	3,4,7	Data Gap

850.1710	72-6	Oyster bioconcentration study – BCF (major
degradate/metabolite of triclosan – e.g., methyl triclosan) 	3,4,7
Study being held in reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.1730	72-6	Fish bioconcentration study 	3,4,7	Data Gap

850.1730	72-6	Fish bioconcentration study – BCF  (major
degradate/metabolite of triclosan – e.g., methyl triclosan)	3,4,7
Study being held in reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.1790	72-6	Chironomid sediment toxicity test	3,4,7	Data Gap

850.1790	72-6	Chironomid sediment toxicity test  (major
degradate/metabolite of triclosan – e.g., methyl triclosan)	3,4,7
Study being held in reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.1850	none	Aquatic food chain transfer	3,4,7	Data Gap

850.1850	none	Aquatic food chain transfer  (major degradate/metabolite
of triclosan – e.g., methyl triclosan)	3,4,7	Study being held in
reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.1735	none	Whole sediment acute toxicity invertebrates, freshwater
3,4,7	Study being held in reserve pending outcome of surface water
monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.1740	none	Whole sediment acute toxicity invertebrates, marine	3,4,7
Study being held in reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.4225	123-1	Seedling Emergence, Tier II	3,4,7	Study being held in
reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

850.4250	123-1	Vegetative Vigor, Tier II	3,4,7	Study being held in
reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)  )

850.5400	123-2	Acute algal dose-response toxicity – marine diatom
3,4,7	44422801

Acute algal dose-response toxicity – freshwater diatom	3,4,7

	Acute algal dose-response toxicity – bluegreen cyanobacteria	3,4,7

	Acute algal dose-response toxicity - duckweed	3,4,7

	850.5400	123-2	Algal toxicity, Tiers 1 and II	3,4,7	Study being held in
reserve pending outcome of surface water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

No current guideline number

Chronic sediment toxicity to freshwater and/or estuarine invertebrates
(TGAI)	3,4,7	Study being held in reserve pending outcome of surface
water monitoring

 (Special Study, Environmental Modeling and Monitoring Specific to
Plastic and Textile Facilities where Triclosan is Incorporated into
these Items)

Special Study for Surface Water Monitoring

Environmental modeling and monitoring specific to plastic and textile
facilities where triclosan is incorporated into these items

Data Gap

TOXICOLOGY

870.1100	81-1	Acute Oral - Rat	3,4,7	43206901

870.1200	81-2	Acute Dermal - Rabbit	3,4,7	94044

100178

870.1300	81-3	Acute Inhalation - Rat	3,4,7	43206902

43310501

870.2400	81-4	Primary Eye Irritation - Rabbit	3,4,7	94045

870.2500	81-5	Primary Dermal Irritation - Rabbit	3,4,7	42306903

870.2600	81-6	Dermal Sensitization	3,4,7	43206502

870.3100	82-1a	90- Day Oral Sub-chronic - Rodent	3,4,7	133545

43022605

43389707

870.3150	82-1	90- Day Oral Sub-chronic Non-rodent	3,4,7	96102

870.3250	82-3	90-Day Dermal Toxicity - Rat	3,4,7	43328001

870.3465	82-4	28/90-Day Inhalation - Rat	3,4,7	0087996

870.3700	83-3	Developmental Toxicity -Rat	3,4,7	43817502

43817503

Developmental Toxicity – Mouse	3,4,7	43817501

Developmental Toxicity – Non-rodent	3,4,7	43022607

43820401

43787101

870.3800	83-4	2 Gen. Reproduction and Fertility Effects	3,4,7	40623701

870.4100a	83-1a	Chronic Toxicity – Hamster 	3,4,7	44751101

870.4100b	83-1b	Chronic Toxicity – Baboon 	3,4,7	133230

870.4200	83-2	Carcinogenicity – Mouse 	3,4,7	FDA Review

870.4300	83-5	Chronic/Oncogenicity – Rat 	3,4,7	161332, 42047906

870.5100	84-2	Bacterial Reverse Mutation Test	3,4,7	44389705

870.5300	84-2	In vitro Mammalian Cell Gene Mutation Test	3,4,7	44389704

870.5375	84-2	In vitro Mammalian Chromosome Aberration Test	3,4,7
47276601

870.5385	84-2	Micronucleus Assay	3,4,7	43740802

870.5500	84-2	Bacterial DNA Damage or Repair Test	3,4,7	47276602

870.7485	85-1	Metabolism and Pharmacokenetics	3,4,7	45307501, 45307502,
45307503

870.7600	85-3	Dermal Penetration	3,4,7	34335

ENVIRONMENTAL FATE

835.2110	161-1	Hydrolysis 	3,4,7	42027908

835-2240	161-2	Photodegradation in Water	3,4,7	43022608

835.4100	162-1	Aerobic Soil Metabolism	3,4,7	47261401

835.4400	162-3	Anaerobic Aquatic Metabolism	3,4,7	Data gap

835.4300	162-4	Aerobic Aquatic Metabolism	3,4,7	47261402

OCCUPATIONAL AND RESIDENTIAL EXPOSURE

875.1700

Product Use Information (applicator)	3,4,7	Data gap

875.2700

Product Use Information (post-applicator)	3,4,7	Data gap

875.2800	133-1	Description of Human Activity	3,4,7	Data gap

875.1200	233	Dermal Indoor Exposure	3,4,7	Data gap

875.1400	234	Inhalation Indoor Exposure	3,4,7	Data gap

875.2300

Indoor Surface Residue Dissipation (infant assessment for mouthing toys)
3,4,7	Data gap

875.1600	236	Applicator Exposure Monitoring Data Reporting	3,4,7	Data
gap

875.2900	134	Data Reporting and Calculations	3,4,7	Data gap

Appendix C.  Technical Support Documents  XE "VI. Appendices:C.
Technical Support Documents"

	Additional documentation in support of this RED is maintained in the
OPP docket, located in Room S-4400, One Potomac Yard, 2777 South Crystal
Drive, Arlington, VA, and is open Monday through Friday, excluding
Federal holidays, from 8:30 a.m. to 4:00 p.m.

	The triclosan docket (EPA-HQ-OPP-2007-0513) initially contained the
April 17, 2008 preliminary risk assessment and the related supporting
science documents.  EPA then considered comments on the risk assessment
and revised the risk assessment and supporting chapters as necessary.
The revised risk assessment, supporting science chapters and Response to
Comments document will be posted in the docket at the same time as the
RED.

	All documents, in hard copy form, may be viewed in the OPP docket room
or downloaded or viewed via the Internet at the following site:

  HYPERLINK "http://www.regulations.gov"  http://www.regulations.gov

These documents include:

Triclosan Preliminary Risk Assessment; Notice of Availability and Risk
Reduction Options, 05/07/2008.

Preliminary Risk Assessment and Supporting Science Documents:

5-Chloro-2-(2,4-dichlorophenoxy)phenol (Triclosan): Risk Assessment for
the 	Reregistration Eligibility Decision (RED) Document.  Case No 2340.
PC Code: 	054901, Antimicrobials Division, April 17, 2008.

Preliminary Ecological Hazard and Environmental Risk Assessment Science
Chapter for the Triclosan Reregistration Eligibility Decision (RED)
Document. 	Case No 2340.  PC Code: 054901, February 22, 2008, Genevieve
Angle, 	Biologist.

Environmental Fate Science Chapter for the Triclosan Reregistration
Eligibility 	Decision (RED) Document. Case No 2340.  PC Code: 054901,
February 06, 	2008, Srinivas Gowda, Microbiologist/Chemist.

Product Chemistry Chapter for the Triclosan Reregistration Eligibility
Decision 	(RED) 	Document. Case No 2340.  PC Code: 054901, October 17,
2007, Srinivas 	Gowda, Microbiologist/Chemist.

Dietary Risk Assessment for Triclosan for the RED Process.  Case No
2340.  PC 	Code: 	054901, April 5, 2007, A. Najm Shamim, PhD., Chemist

Triclosan, Occupational and Residential Exposure Assessment.  Case No
2340.  	PC Code: 054901, Antimicrobials Division, April 17, 2008.

Revised   SEQ CHAPTER \h \r 1 5-Chloro-2-(2,4-dichlorophenoxy)phenol
(Triclosan): Toxicology 	Chapter for the Reregistration Eligibility
Decision (RED) Document. Case No 	2340.  PC Code: 054901, May 14, 2008,
Tim McMahon, Ph.D., Senior 	Toxicologist

Triclosan:  Report of the Cancer Assessment Review Committee, Jessica
Kidwell, 	January 4, 2008

Revised Risk Assessment and Supporting Science Documents (RED Supporting
Documents):

Reregistration Eligibility Decision (RED) Document for Triclosan. Case
No 2340.  PC Code: 054901, Antimicrobials Division, September 18, 2008.

  SEQ CHAPTER \h \r 1 5-Chloro-2-(2,4-dichlorophenoxy)phenol
(Triclosan): Risk Assessment for the Reregistration Eligibility Decision
(RED) Document.  Case No 2340.  PC Code: 054901, September 15, 2008, Tim
McMahon, Ph.D., Senior Toxicologist.

  SEQ CHAPTER \h \r 1 5-Chloro-2-(2,4-dichlorophenoxy)phenol
(Triclosan): Toxicology Chapter for the Reregistration Eligibility
Decision (RED) Document.  Case No 2340.  PC Code: 054901, August 29,
2008, Tim McMahon, Ph.D., Senior Toxicologist.

Triclosan, Occupational and Residential Exposure Assessment.  Case No
2340.  PC Code: 054901, Antimicrobials Division, September 8, 2008.

Revised Environmental Fate Science Chapter for the Triclosan
Reregistration 	Eligibility Decision (RED) Document. Case No 2340.  PC
Code: 054901, 	September 11, 2008, 	Srinivas Gowda,
Microbiologist/Chemist.

Revised Ecological Hazard and Environmental Risk Assessment Science
Chapter for the Triclosan Reregistration Eligibility Decision (RED)
Document. Case No 2340.  PC Code: 054901, September 11, 2008, Richard C.
Petrie, Agronomist, Team 3 Leader.

TRICLOSAN: Revised Report of the Hazard Identification Assessment Review
Committee and Antimicrobial Division Toxicity Endpoint Committee. August
29, 2008, Tim McMahon, Ph.D., Senior Toxicologist.

Product Chemistry Chapter for the Triclosan Reregistration Eligibility
Decision (RED) Document. Case No 2340.  PC Code: 054901, October 17,
2007, Srinivas Gowda, Microbiologist/Chemist.

Dietary Risk Assessment for Triclosan for the RED Process.  Case No
2340.  PC 	Code: 	054901, August 11, 2008, A. Najm Shamim, PhD., Chemist

Estimates of Exposures and Risks to Aquatic Organism from Releases of
Triclosan to Surface Water as a Result of Uses under the EPA’s
Jurisdiction. Risk Assessment and Science Support Branch (RASSB),
Patricia Jennings, September 4, 2008

Appendix D.	Citations Considered to be Part of the Data Base Supporting
the Reregistration Decision (Bibliography)  XE "VI. Appendices:D.
Bibliography Citations"

GUIDE TO APPENDIX D

1.	CONTENTS OF BIBLIOGRAPHY.  This bibliography contains citations of
all studies considered relevant by EPA in arriving at the positions and
conclusions stated elsewhere in the triclosan Reregistration Eligibility
Document.  Primary sources for studies in this bibliography have been
the body of data submitted to EPA and its predecessor agencies in
support of past regulatory decisions.  Selections from other sources
including the published literature, in those instances where they have
been considered, are included.

2.	UNITS OF ENTRY.  The unit of entry in this bibliography is called a
“study.”  In the case of published materials, this corresponds
closely to an article.  In the case of unpublished materials submitted
to the Agency, the Agency has sought to identify documents at a level
parallel to the published article from within the typically larger
volumes in which they were submitted.  The resulting “studies”
generally have a distinct title (or at least a single subject), can
stand alone for purposes of review and can be described with a
conventional bibliographic citation.  The Agency has also attempted to
unite basic documents and commentaries upon them, treating them as a
single study.

3.	IDENTIFICATION OF ENTRIES.  The entries in this bibliography are
sorted numerically by Master Record Identifier, or “MRID” number.
This number is unique to the citation, and should be used whenever a
specific reference is required.  It is not related to the six-digit
“Accession Number” which has been used to identify volumes of
submitted studies (see paragraph 4(d)(4) below for further explanation).
 In a few cases, entries added to the bibliography late in the review
may be preceded by a nine character temporary identifier.  These entries
are listed after all MRID entries.  This temporary identifying number is
also to be used whenever specific reference is needed.

4.	FORM OF ENTRY.  In addition to the Master Record Identifier (MRID),
each entry consists of a citation containing standard elements followed,
in the case of material submitted to EPA, by a description of the
earliest known submission.  Bibliographic conventions used reflect the
standard of the American National Standards Institute (ANSI), expanded
to provide for certain special needs.

a.	Author.  Whenever the author could confidently be identified, the
Agency has chosen to show a personal author.  When no individual was
identified, the Agency has shown an identifiable laboratory or testing
facility as the author.  When no author or laboratory could be
identified, the Agency has shown the first submitter as the author.

b.	Document date.  The date of the study is taken directly from the
document.  When the date is followed by a question mark, the
bibliographer has deduced the date from the evidence contained in the
document.  When the date appears as (1999), the Agency was unable to
determine or estimate the date of the document.

c.	Title.  In some cases, it has been necessary for the Agency
bibliographers to create or enhance a document title.  Any such
editorial insertions are contained between square brackets.

d.	Trailing parentheses.  For studies submitted to the Agency in the
past, the trailing parentheses include (in addition to any
self-explanatory text) the following elements describing the earliest
known submission:

(1)	Submission date.  The date of the earliest known submission appears
immediately following the word “received.”

(2)	Administrative number.  The next element immediately following the
word “under” is the registration number, experimental use permit
number, petition number, or other administrative number associated with
the earliest known submission.

(3)	Submitter.  The third element is the submitter.  When authorship is
defaulted to the submitter, this element is omitted.

(4)	Volume Identification (Accession Numbers).  The final element in the
trailing parentheses identifies the EPA accession number of the volume
in which the original submission of the study appears.  The six-digit
accession number follows the symbol “CDL,” which stands for
“Company Data Library.”  This accession number is in turn followed
by an alphabetic suffix which shows the relative position of the study
within the volume.

MRID Studies

MRID #				Citation

34335		Stierlin, H. (1968) “Percutaneous Absorption of GP 41 353 in
the Rat and 			the Rabbit.” (Unpublished study; prepared by J.R.
Geigy, AG, submitted 			by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:000506-M).

43429		Stenger, E.G.; Scharer, (1963) “Local Effects on Rabbit's
Eye.” 				(Unpublished study; prepared by J.R. Geigy, AG, Switzerland,
submitted 			by Ciba-Geigy Corp., Greensboro, N.C.; CDL:108210-J).

94044		Ullmann, L. (1980) Report on Acute Dermal LD50 in the Rabbit of
FAT 			80023/A: Project No. 800761. (Unpublished study received Jan 28,
1982 			under 100-502; prepared by Ciba-Geigy Ltd., Switzer- land,
submitted by 			Ciba-Geigy Corp., Greensboro, N.C.; CDL: 246688-A)

94045		Ullmann, L. (1980) Report on Eye Irritation in the Rabbit after
Single 			Application of FAT 80023/A: Project No. 801012. (Unpublished
study 			received Jan 28, 1982 	under 100-502; prepared by Ciba-Geigy
Ltd., 			Switzerland, submitted by Ciba-Geigy Corp., Greensboro, N.C.;
		CDL:246688-B)

96102              Burther, B.R.; Gordon, D.E. (1973) “Report to
Ciba-Geigy Corporation: 			90-day Subacute Oral Toxicity Study with
Irgasan DP-300 in Beagle 			Dogs: IBT No. C1435.” (Unpublished study;
prepared by Industrial Bio-			Test Laboratories, Inc., submitted by
Ciba-Geigy Corp., Greensboro, N.C.; 		CDL:008400-C)

100178	Schoenig, G. (1967) “Report to Geigy Chemical Company: Acute
	Dermal Toxicity Study on CH 3565: IBT No. A5460.” (Unpublished
study; prepared by Industrial Bio-Test Laboratories, Inc., submitted by
		Ciba-Geigy Corp., Greensboro, N.C.; CDL:000503-D).

130187  	Schoenig, G. (1967) “Report to Geigy Chemical Company: Acute
			Dermal Toxicity Study on CH 3565: IBT No. A5460.” (Unpublished
study; prepared by Industrial Bio-Test Laboratories, Inc., submitted by
		Ciba-Geigy Corp., Greensboro, N.C.; CDL:000503-D)

133545	Goldsmith, L. (1983) 90-Day Oral Toxicity Study in Rats with Fat
			80’023/H: LBI Project No. 22188. Final Report.  (Unpublished study
		received Dec. 23, 1983 under 100-502; submitted by Ciba-Geigy Corp.)

149464	Stierlin, H. (1972) Study of Pharmacokinetics and Metabolism in
Mouse, 			Rat, Rabbit and Dog: GP 41 353: Report No. 33/1972. Un-
published 			study prepared by Ciba-Geigy Ltd. 31 p.

40623701	Morseth, S.L. (1988) “Two-Generation Reproduction Study in
Rats with 			FAT 80’02390” Hazleton Laboratories America, Inc.

41008910  	Terrell, Y.  1985.  Acute Oral Toxicity Study of Issue Plus
II; ID No. 88-			472; Prepared by American Standards Biosciences Corp.
for Diversey 			Wyandotte Corporation, Wyandotte, Michigan.

41008911  	Terrell, Y.  1988.  Avian Dietary Quaily (Litmus Test) of
Issue Plus in 			Bobwhite Quail; Project No. 88-471; Prepared by
American Standard 			Biosciences Corp. for Diversey Wyandotte
Corporation, Wyandotte, 			Michigan.

41008912  	Terrell, Y.  1988.  The Acute Toxicity Bioassay of Issue Plus
on Rainbow 			Trout; Project No. 88-474; Prepared by American Standard
Biosciences 			Corp. for Diversey Wyandotte Corporation, Wyandotte,
Michigan.

41008913  	Terrell, Y.  1988.  The Acute Toxicity Bioassay of Issue Plus
on Bluegill 			Sunfish; Project No. 88-473; Prepared by American
Standard Biosciences 			Corp. for Diversey Wyandotte Corporation,
Wyandotte, Michigan.

41008914  	Terrell, Y.  1988.  Acute Toxicity of Issue Plus on Daphnia
magna; 			Project No. 88-475; Prepared by American Standard Biosciences
Corp. for 		Diversey Wyandotte Corporation, Wyandotte, Michigan.

42027901	LoMenzo, J. (1991) Irgasan DP 300: Product Identity and
Composition. Unpublished study prepared by Ciba-Geigy Corp.

42027902	Basingthwaite, J. (1983) Irgasan DP 300: Batch Analysis and
Analytical Methodology. Unpublished study prepared by Ciba-Geigy Ag.

42027904	Vogel, A. (1990) Irgasan 300 DP: Report on Melting
Point/Melting Range. Unpublished study prepared by Ciba-Geigy Ltd.

42027906	Study 1 - Yau, E.T. and Green, J.D. (1986) Fat 80’023 2 Year
Oral 			Administration to Rats; Study 2 – Parkes, D.G. (1986)
Determination of 			Fat 80’023 in Blood and Tissue Samples Taken
During a Two-Year 			Chronic Oral Toxicity/Oncogenicity Study in Albino
Rats (24-month Final 		Report).  Ciba-Geigy Corporation.

42027908	Pointurier, R. 1990.  Irgasan® DP 300 – Report on Hydrolysis
as a 				Function of pH.  Unpublished study performed and submitted by
Ciba-			Geigy Ltd., Basel, Switzerland.

42306902	Duchosal F. and Ph. Thevenaz (1990) “4-Hour Acute Inhalation
Toxicity 			Study with FAT 80’023/Q in Rats”  Ciba-Geigy Ltd.

42306903	Sachsse, K.; Ullman, L. (1975) Skin Irritation in the Rabbits
after Single 			Application of FAT 80’023/A.  Unpublished Study
Conducted by Ciba 			Geigy Ltd., Basel Switzerland.  Project No. Siss
4719.  Submitted to EPA 			by Chemical Division of Ciba Geigy Corp.
(9/11/75).

42322101  	Boettcher, J.  1990.  Report on the Acute Toxicity (96h) of
FAT 80, 023/Q 		to Zebrafish.  Test No. G 069 04.  Prepared by
Ciba-Geigy, Ltd., D&C 			Product Ecotoxicology, Basel, Switzerland.
Submitted by Ciba-Giegy 			Corporation, Greensboro, North Carolina.

42322102	Wuethrich, V.  1990.  48-Hour Acute Toxicity of FAT 80, 023/Q
to 			Daphnia magna (OECD-Immobilization Test).  Project No. 262923.
Prepared by RCC Umweltchemie AG, Itingen, Switzerland.  Submitted by
Ciba-Giegy Corporation, Greensboro, North Carolina.

43022601	Morrissey, M. (1993) Stability Determination of Irgasan DP 300
in the Presence of Metal: Final Report: Lab Project Number: HWI
6117-246. Unpublished study prepared by Hazleton Wisconsin, Inc.

43022602	Pedersen, C.A. and B.R. Helsten.  1993.  Triclosan (IRGASAN
DP300(): 			14-Day Acute Oral LD50 Study in Bobwhite Quail.  Study
performed by 			Bio-Life Associates, Ltd., Neillsville, Wisconsin.
Laboratory Project No. 			102-024-03. Submitted by CIBA-GEIGY
Corporation, Greensboro, North 			Carolina.

43022603	Pedersen, C.A. and B.R. Helsten.  1993.  Triclosan (IRGASAN
DP300(): 			14-Day Acute Oral LD50 Study in Mallard Ducks.  Study
performed by 			Bio-Life Associates, Ltd., Neillsville, Wisconsin.
Laboratory Project No. 			102-023-04. Submitted by CIBA-GEIGY
Corporation, Greensboro, North 			Carolina.

43022604	Pedersen, C.A. and B.R. Helsten.  1993.  Triclosan (IRGASAN
DP300(): 			8-Day Acute Dietary LC50 Study in Bobwhite Quail.  Study
performed by 			Bio-Life Associates, Ltd., Neillsville, Wisconsin.
Laboratory Project No. 			102-022-01. Submitted by CIBA-GEIGY
Corporation, Greensboro, North 			Carolina.

43022605	Trutter, Janet A.  (1993)  “13-Week Subchronic Oral Toxicity
Study of 			Triclosan in CD-1® Mice.”  Hazleton Washington, Inc.

43022607	Schroeder, R.E. et al. (1992) “A Segment II Teratology Study
in Rabbits 			with Irgacare MP” Bio/dynamics Inc.

43022608	Spare, W. 1993.  Aqueous Photolysis of Triclosan.  Agrisearch
Project No.: 12208.  Unpublished study performed by Agrisearch Inc.,
Frederick, MD; and submitted by Ciba-Geigy Corporation, Greensboro, NC.

43046001	Bowman, J.H.  1990.  Acute Toxicity of D1063.01 (Triclosan:
Irgasan DP300) to Fathead Minnow (Pimephales promelas).  Laboratory
Project ID No. 38655.  Prepared by Analytical Bio-Chemistry
Laboratories, Inc, Columbia, Missouri.  Submitted jointly by Proctor and
Gamble Company and Ciba-Geigy Corp.

43046002	Forbis, A.D. and J.G. Muckerman.  1990.  Acute Toxicity of
D1063.01 			(Triclosan: Irgasan DP300) to Daphnia magna.  Laboratory
Project ID No. 		38656.  Prepared by Analytical Bio-Chemistry
Laboratories, Inc, 				Columbia, Missouri.  Submitted jointly by Proctor
and Gamble Company 			and Ciba-Geigy Corp.

43206501	Wnorowski, Gary.  (1994) “Acute Toxicity Limit Test for
Triclosan 			Irgasan® DP 300) Product Safety Labs.

43206502	Wnorowski, G. (1994) Dermal Sensitization Test-Buehler Method
for 			Triclosan (Irgasan® DP 300) Lot No. 5.2.0211.0.  Product Safety
Labs; 			Study No. 2635.  Submitted to EPA by Ciba-Geigy Corp.
Unpublished.

43277801	Morrissey, M. (1994) Stability Determination of Irgasan DP300
Exposed to Metal Ions: Final Report: Lab Project Number: HWI 6117-261.
Unpublished study prepared by Hazleton Wisconsin, Inc.

43277802	Schatowitz, B. (1990) Additional Data Required by the US EPA
for the Results of the Analysis of Irgasan DP300 for Dioxins/Furans: Lab
Project Number: 102290. Unpublished study prepared by Ciba-Geigy Ltd.

43310501	Duchosal F. and Ph. Thevenaz (1990) “4-Hour Acute Inhalation
Toxicity 			Study with FAT 80’023/Q in Rats”  Ciba-Geigy Ltd.

43328001	Trimmer, Gary W.  (1994) “90-Day Subchronic Dermal Toxicity
Study in 			the Rat with Satellite Group with Irgasan DP300
(MRD-92-399)” Exxon 			Biomedical Sciences, Inc.

43533301	Jones, E., Wilson, L.A. (1988) “Ames Metabolic Activation
Test to 			Address the Potential Mutagenic Effect of Triclosan (Irgasan
DP 300)” 			Huntingdon Research Center, Ltd. Cambridgeshire, England.

43533901	Schatowitz, B. (1995) Additional Data Required by the U.S. EPA
for the 			Product Analysis of Irgasan DP 300: Lab Project Number:
11995. 				Unpublished study prepared by Ciba Research Services.

43740701	Wuethrich, V.  1990.  Influence of FAT 80023/Q (Irgasan DP300)
on 			Reproduction of Daphnia magna.  Project No. 262934.  Prepared by
RCC 			Umweltchemie AG, Itingen, Switzerland.  Submitted by Ciba-Giegy
AG, 			Basel, Switzerland.

43740801	Heidemann, A. (1990) “Chromosome Aberration Assay in Chinese
		Hamster V79 Cells In Vitro with FAT 80’023/Q (Irgasan® DP 300);
Cytotest Cell Research GMBH & Co. KG, Federal Republic of Germany;
Study No. 179100.  Unpublished.

43740802	Volkner, W. (1991) “Chromosome Aberration Assay in Bone
Marrow 			Cells of the Rat with FAT 80’023/Q (Irgasan® DP300);
Cytotest Cell 			Research GMBH & Co. KG, Federal Republic of Germany;
Study No. 			218305.  Unpublished.

43817502	Denning, H.J., Sliwa, S., and Willson, G.A. (1992)
“Triclosan: Effects on 			Pregnancy and Post-Natal Development in
Rats: Volume 1, Volume 2 and 			Appendices 1-17” Unilever Research,
Colworth/ Welwyn Lab.

43817503	Denning, H.J., Sliwa, S., and Willson, G.A. (1992)
“Triclosan: Effects on 			Pregnancy and Post-Natal Development in
Rats: Volume 1, Volume 2 and 			Appendices 1-17” Unilever Research,
Colworth/ Welwyn Lab.

43820401	Schroeder, R.E. et al. (1992) “A Segment II Teratology Study
in Rabbits 			with Irgacare MP” Bio/dynamics Inc.

43969301	Sword, M.C.  1996.  Static Acute Toxicity of Triclosan to
Rainbow Trout.  		Study performed by ABC Laboratories, Inc., Columbia,
Missouri.  				Laboratory Report No. 42997.  Sponsored by CIBA Chemical
Division, 			Greensboro, North Carolina.

44389701	Eldrige, S. (1993) Cell Proliferation in Rodent Liver:
(Triclosan): Final 			Report: Lab Project Number: 142. Unpublished study
prepared by 				Pathology Associates, Inc. 14 p.

44389702	Molitor, E., Persohn, E., Thomas, H. “The Effect of FAT
80’023/Q 			(Irgasan DP 300) on Selected Biochemical Liver Parameters
Following 			Subchronic Dietary Administration to Male and Female Mice.
Ciba-			Geigy Limited, Switzerland, Report CB 91/18, May 22, 1992.

44389703	Molitor, E.; Persohn, E. (1993) The Effects of FAT 80’023/Q
(Irgasan DP 			300) on Selected Biochemical and Morphological Liver
Parameters 			Following Dietary Administration to Male Rats: Lab Project
Number: CB 			92/28.  Unpublished study prepared by Ciba-Geigy Ltd. 70p.

44389704	Henderson, L.M., et al.  (1988) An Assessment of the Mutagenic
Potential 		of Triclosan Using the Mouse Lymphoma TK Locus Assay.
Huntingdon 			Research Center Ltd., Huntingdon, Cambridgeshire, PE18
6ES, England. 			Study No. ULR 216/88644. Unpublished.

44389705	Stankowski, L.F., Jr. et al. (1993) Amended Final Report,
Ames/Salmonella Plate Incorporation Assay on Test Article 39316 (CC
#14663-09).  Pharmakon USA, P.O. Box 609, Waverly, PA.  Laboratory
Study Report No. PH 301-CP-001-93.  Unpublished.

44389706	Thomas, Rer. Nat. H. (1994) The Effect of FAT 80’023/Q and
the Model 			Inducers Phenobarbitone, 3-Methylcholanthrene, Pregnenolone
16 ∞ -			carbonitrile and Nafenopin on Selected Biochemical and
Morphological 			Liver Parameters in the Syrian Hamster.  Study
conducted by Ciba-Geigy 			Limited.  Study number CB 93/40.
Unpublished.

44389707	Thevenaz, Dr. Phil.  (1987) Final Report: FAT 80023: 28-Day
Toxicity 			Study in Mice (Administration in Feed) with Special
Reference to 				Histopathology.  Ciba-Geigy Ltd., Basle, Switzerland.
Unpublished.

44389708	Burns, J.M. (1997) 14-Day Repeated Dose Dermal Study of
Triclosan in 			CD-1 Mice.  Corning Hazleton Incorporated (CHV), 9200
Leesburg Pike, 			Vienna, Virginia.  Laboratory Study No. CHV 2763-100.
April 29, 1997.  		Unpublished.

44389710	Burns, J.M. (1997) 14-Day Repeated Dose Dermal Study of
Triclosan in 			Rats.  Corning Hazleton Incorporated (CHV), 9200
Leesburg Pike, 			Vienna, Virginia.  Laboratory Study No. CHV 6718-102.
Unpublished.

44422801	Staveley, J.P. and T.L. Williams.  1997.  Effects of Triclosan
on the 			Growth and Reproduction of Aquatic Plants.  Study performed by
				Carolina Ecotox, Inc., Durham, North Carolina.  Laboratory Report
ID: 			21-02-1.  Sponsored by Ciba-Geigy Corporation, Greensboro, North
		Carolina.

44751101	Chambers, P.R. (1999) “Potential Tumorigenic and Chronic
Toxicity 			Effects in Prolonged Dietary Administration to Hamsters.”
Huntingdon 			Life Sciences Ltd., Huntingdon, England. CBG 756/972896.

44874001	Chambers, P.R. (1999) “Potential Tumorigenic and Chronic
Toxicity 			Effects in Prolonged Dietary Administration to Hamsters.”
Huntingdon 			Life Sciences Ltd., Huntingdon, England. CBG 756/972896.

45307501	Van Dijk, Dr. A. (1994) “14C- Triclosan: Absorption,
Distribution, 				Metabolism, and Elimination after Single/Repeated Oral
and Intravenous 				Administration to Hamsters.”  RCC Umweltchemie AG.
 RCC 				Project No. 351707.

45307502	Van Dijk, Dr. A. (1994) “14C- Triclosan: Absorption,
Distribution, 				Metabolism, and Elimination after Single/Repeated Oral
and Intravenous 			Administration to Hamsters.”  RCC Umweltchemie AG.
RCC Project No. 		351707.

45307503	Van Dijk, Dr. A. (1995) “14C- Triclosan: Absorption,
Distribution, 				Metabolism, and Elimination after Single/Repeated Oral
and Intravenous 			Administration to Mice.”  RCC Umweltchemie AG.  RCC
Project No. 			337781.

47261401	Adam, D. (2007) (Carbon 14)-Triclosan: Degradation and
Metabolism in Three Soils Incubated Under Aerobic Conditions. Project
Number: B12835. Unpublished study prepared by RCC Umweltchemie Ag.

47261402	Adam, D. (2006) (Carbon 14)-Triclosan: Route and Rate of
Degradation in Aerobic Aquatic Sediment Systems. Project Number: A33300.
Unpublished study prepared by RCC Umweltchemie Ag.

47261403	Volkel, W. (2007) The Effects of Triclosan on Soil
Nitrification. Project Number: A89954. Unpublished study prepared by RCC
Umweltchemie Ag.

47261404	Volkel, W. (2006) The Effects of Triclosan on Soil Respiration.
Project Number: A88312. Unpublished study prepared by RCC Umweltchemie
Ag.

47261406	Christensen, K. (1994) Triclosan - Determination of Anaerobic
Aquatic Biodegradation. Project Number: 93/12/5076. Unpublished study
prepared by Springborn Laboratories Inc.

47261407	Christensen, K. (1994) Triclosan - Aerobic Biodegradation in
Water. Project Number: 93/4/4731. Unpublished study prepared by
Springborn Laboratories Inc.

47276601 	Broker, P.C., Gray, V.M., Howell, A.  (1988)  “Analysis of
Metaphase 			Chromosomes Obtained from CHO Cells Cultured in vitro and
Treated 			with Triclosan.” Huntingdon Research Center, Ltd. ULR
214/88731; 			Unilever Test #: KC880171. Unpublished.

47276602 	San Sebastian, J.R., Morgan, J.M. (1993) “Rat Hepatocyte
Primary 			Culture/DNA Repair Test on 39317” Pharmakon Research
International, 			Inc. Pharmakon Study #: PH311-CP-001-93.  Unpublished.

MRID Studies

Accession #				Citation

251773	Drake, J.C. & Buxtorf, A. (1976) 1 Year Oral Toxicity Study in
Baboons 			with Compound FAT 80 023/A.  Geigy Pharmaceuticals,
Toxicology 			Department, MRID # 133230.

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Shiratsuchi, H; Kai, T;  	Nishimura, T.; Kashiwagi,  A.. and Arizono,
K. 2005. Effects of nonylphenol and 	triclosan on production of plasma
vitellogenin and testosterone in male South 	African clawed frogs
(Xenopus laevis).Biol. Pharm. Bull. 28: 1748–1751.

McAvoy, D.C., Schatowitz, B., Martin, J., et al. 2002. Measurement Of
Triclosan In 	Wastewater Treatment Systems. Environmental Toxicology and
Chemistry. 21 	(7): 1323-9.

McAvoy, D.C., Schatowitz, B., Martin, J., et al. 2002. Measurement Of
Triclosan In 	Wastewater Treatment Systems. Environmental Toxicology and
Chemistry. 21 	(7): 1323-9.

Mezcua, M., Gomez, M.J., Ferrer, I., et al. 2004. Evidence of
2,7/2,8-Dibenzodichloro-p-	dioxin 	As A Photodegradation Product Of
Triclosan In Water And Wastewater 	Samples. Analytica Chimica Acta. 524
(1-2): 241-247.

Morales, S., Canosa, P., and Rodriguez, I., et al. 2005. Microwave
Assisted Extraction 	Followed by Gas Chromatography with Tandem Mass
Spectrometry for the 	Determination of Triclosan and Two Related
Chlorophenols in Sludge and 	Sediments. Journal of 	Chromatography.
1082: 128-35.

Nakada, N., Toshikatsu, T., and Hiroyuki, S., et al. 2006.
Pharmaceutical Chemicals and 	Endocrine Disrupters in Municipal
Wastewater in Tokyo and their Removal 		during 	Activated Sludge
Treatment. Water Research. 40(17): 3297-303.

Palenske, N.M., Dzialowski, E.M (2005). Effects of the Environmental
Contaminant 	Triclosan on the Physiology of Developing Xenopus Laevis
Tadpoles. Integrative 	and Comparative Biology. 45(6): 1175. Published.

Paxeus, N., and Gryaab, K. 2004. Removal Of Selected Non-Steroidal
Anti-Inflammatory 	Drugs 	(NSAIDs), Gemfibrozil, Carbamazepine,
Beta-Blockers, Trimethoprim 	And Triclosan In Conventional Wastewater
Treatment Plants In Five EU 	Countries And Their Discharge To The
Aquatic Environment. Water Science and 	Technology. 50 (5): 253-60.

Sabaliunas, D., Webb, S.F., Hauk, A., et al. 2003. Environmental Fate Of
Triclosan In 	The River Aire Basin, UK. Water Research (England). 37:
3145-54.

Samsoe-Petersen L.,Winther-Nielsen M., Madsen T. Fate and Effects of
Triclosan.

	San Sebastian, J.R., Morgan, J.M. (1993) “Rat Hepatocyte Primary
Culture/DNA 	Repair 	Test on 39317” Pharmakon Research International,
Inc. Pharmakon Study 	#: PH311-CP-	001-93.  Unpublished.

Sandborgh-Englund G, Adolfsson-Erici M, Odham G, and Ekstrand J.  2006.
	Pharmacokinetics of Triclosan Following Oral Ingestion in Humans.
Journal of 	Toxicology and Environmental Health, Part A, 69:1861-1873,
2006.

Schafer, K.S,, Reeves, M., Spitzer, S., Kegley, S. E. 2004. Chemical
Trespass: Pesticides 	in Our 	Bodies and Corporate Accountability.
Pesticide Action Network North 	America. May 2004.

See, Norman A.  (1996) Review and Evaluation of Pharmacology and
Toxicology Data 	Division of Dermatologic and Dental Drug Products
(HFD-540) Food and Drug 	Administration.

Shiraishi, H., Otsuki, A., and Fuwa, K. 1985. Identification of
Extractable Organic 	Chemicals In 	Sewage Effluent By Gas
Chromatography/Mass Spectrometry. 	Biomedical Mass Spectrometry. 12 (2):
86-94.

Singer, H., Muller, S., Tixier, C., et al. 2002. Triclosan: Occurrence
and Fate Of A 	Widely Used 	Biocide In The Aquatic Environment: Field
Measurements In 	Wastewater Treatment Plants, Surface Waters, And Lake
Sediments. 	Environmental Science and Technology. 36(23): 4998-5004.

Tamura,H., Y. Ishimoto., T. Fujikawa et al. (2006). Use of Structural
basis for androgen 	receptor agonists and  Antagonists: Interaction of
SPEED 98-listed chemicals and  	Related compounds with the androgen
receptor based on an In vitro reporter gene 	assay and 3D-	QSAR.  to be
Assigned. Bioorganic & Medicinal Chemistry. 	14:7160-7174.

Thomas, P.M., and Foster, G.D. 2004. Determination of Nonsteroidal
Anti-inflammatory 	Drugs, 	Caffeine, and Triclosan in Wastewater by Gas
Chromatography-Mass 	Spectrometry.2004. Journal of Environmental Science
and Health.  Part A, 	Toxic/Hazardous Substances & Environmental
Engineering. 39(8): 1969-78.

Thomas, P.M., and Foster, G.D. 2005. Tracking Acidic Pharmaceuticals,
Caffeine, And 	Triclosan Through The Wastewater Treatment Process.
Environmental 	Toxicology and Chemistry. 24 (1): 25-30.

Thompson, A., Griffin, P., and Stuetz, R., et al. 2005. The Fate and
Removal of Triclosan 	during Wastewater Treatment.  Water Environment
Research. 77(1):63-67.

Veldhoen, N; Skirrow, RC; Osachoff, H.; Wigmore, H; Clapson, DJ;
Gunderson, MP; 	Aggelen, GV; Helbing, CC. (2006).  The bactericidal
agent triclosan modulates 	thyroid hormone-associated gene expression
and disrupts postembryonic anuran 	development.  Aquatic Toxicology 80:
217–227.

Waltman, E.L., Venables, B.J., and Waller, W.T. 2006. Triclosan In A
North Texas 	Wastewater Treatment Plant And The Influent And Effluent Of
An Experimental 	Constructed Wetland. Environmental Toxicology and
Chemistry. 25 (2): 367-72.

Wind, T., Werner, U., Jacob, M., et al. 2004. Environmental
Concentrations Of Boron,  	LAS, EDTA, NTA and Triclosan Simulated with
GREAT-ER in the river Itter. 	Chemosphere 	(England). 54: 1135-44.

Ying, G. and Kookana, R.S. 2007. Triclosan In Wastewaters And Biosolids
From 	Australian Wastewater Treatment Plants. Environmental
International. 33 (2): 	199-205.

Website References

Citation

DOE.  1997.  Energy Information Administration: Profile of Commercial
Buildings in 	1995.  	  HYPERLINK
"http://www.eia.doe.gov/emeu/cbecs/char95/profile.html"
http://www.eia.doe.gov/emeu/cbecs/char95/profile.html

Estimation Programs Interface (EPI) Suite.  Windows based suite of
physical/chemical 	properties and environmental estimation models
developed by the US EPA’s 	Office of Prevention, 	Pesticides and Toxic
substances (OPPTS) and Syracuse 	Research Institute (SRC).  Physical
properties of Triclosan.  EPI Suite Summary 	(v3.12).   HYPERLINK
"http://www.epa.gov/opptintr/exposure/docs/EPISuitedl.htm"
http://www.epa.gov/opptintr/exposure/docs/EPISuitedl.htm

FDA, 2003, A Guidance For Industry: Preparations of food Contact
Notifications and 	Food Additive Petitions for Food Contact Substances,
Chemistry 	Recommendations. Final Guidance, April 2003.   HYPERLINK
"http://www.cfsan.fda.gov"  http://www.cfsan.fda.gov

FDA, 2003.  Sanitizing  Solutions: Chemistry Guidance for Food Additive
Petitions, 	January 2003.   HYPERLINK "http://www.cfsan.fda.gov"
http://www.cfsan.fda.gov

Hazard Substances Data Bank (HSDB).  A Database of the National Library
of 	Medicine’s TOXNET System.  Triclosan:  Environmental Fate and
Exposure. 	 HYPERLINK
"Triclosan%20Fate%20Chapter%20for%20RED.updated%2012-21-06.doc"
http://toxnet.nlm.nih.gov

Guidance on Cumulative Risk Assessment of Pesticide Chemicals that Have
a Common 	Mechanism of Toxicity, Office of Pesticide Programs, 2002.
HYPERLINK
"http://www.epa.gov/pesticides/trac/science/cumulativeguidance.pdf"
http://www.epa.gov/pesticides/trac/science/cumulativeguidance.pdf

Public Health Action Plan to Combat Antimicrobial Resistance.
Interagency Task Force 	on Antimicrobial Resistance.	  HYPERLINK
"http://www.cdc.gov/drugresistance/actionplan/aractionplan.pdf"
http://www.cdc.gov/drugresistance/actionplan/aractionplan.pdf

Other Supporting Documents

Citation

AD Memo by Tim McMahon  to Jess Rowland, Executive Secretary for
Agency’s 	HIARC Committee, 1998.

Calculations reported by Bob Quick in an AD  Memo by Bob Quick to Bob
Brennis, 	1998.Capen, C. Toxic Responses of the Endocrine System. In:
Casarett and 	Doull’s Toxicology: The Basic Science of Poisons, 5th
ed., Curtis D. Klaassen, 	Ph.D., editor. 	McGraw-Hill.

Environment Project No. 861. Copenhagen: Danish Environmental Protection
Agency; 	2003.

Tox Record No. 001955, 001956 (1968).

Tox Record No. 001968 (1977).

USEPA. 1996.  Office of Research and Development, Descriptive Statistics
Tables from

	a Detailed Analysis of the National Human Activity Pattern (NHAPS)
Data;

	EPA/600/R-96/148, July 1996.   Data Collection Period October 1992 -
September 1994.

USEPA.  1997.  Exposure Factors Handbook. Volume I-II.  Office of
Research and 	Development.  Washington, D.C.  EPA/600/P-95/002Fa. August
1997.

USEPA. 1998. PHED Surrogate Exposure Guide. Estimates of Worker Exposure
from

	the Pesticide Handler Exposure Database Version 1.1.   Washington, DC:
U.S.

 	Environmental Protection Agency.

  SEQ CHAPTER \h \r 1 USEPA. 1999.  Evaluation of Chemical Manufacturers
Association Antimicrobial 	Exposure Assessment Study (Amended on 8
December 1992).  Memorandum 	from Siroos Mostaghimi, PH.D., USEPA to
Julie Fairfax, USEPA. Dated 	November, 4 1999.  DP Barcode D247642.

USEPA.  2000.  Residential SOPs.  EPA Office of Pesticide Programs,
Human Health

	Effects Division. Dated April 5, 2000.

USEPA.  2001.  HED Science Advisory Council for Exposure. Policy Update,
November 	12.  Recommended Revisions to the Standard Operating
Procedures (SOPs) for 	Residential Exposure Assessment, February 22,
2001.

USEPA.  2002. CHILD-SPECIFIC EXPOSURE FACTORS HANDBOOK (INTERIM
REPORT). USEPA EPA-600-P-00-002B. 01 Sep 2002. U.S. Environmental
Protection Agency, Office of Research and Development, National Center
for 	Environmental Assessment, Washington Office, Washington, DC, 448.

USEPA.  2007.  5-Chloro-2-(2,4-dichlorophenoxy)phenol (triclosan):
Toxicology 	Chapter for the Reregistration Eligibility Decision (RED)
document.

USEPA   2008. T. E. Stoker and W. Setzer. The Endocrine Disrupting
Effects of 	Triclosan, a common pharmaceutical and personal care
product: Alteration of the 	Thyroid Axis Following a Peri-juvenile
Exposure in the Male Wistar Rat. 	EPA/600/X-08/010.

Appendix E. Generic Data Call-In

The Agency intends to issue a Generic Data Call-In at a later date.  See
Chapter V of the triclosan RED for a list of studies that the Agency
plans to require.

Appendix F. Product Specific Data Call-In

The Agency intends to issue a Product Specific Data Call-In at a later
date.

Appendix G.  Batching of Triclosan Products for Meeting Acute Toxicity
Data Requirements for Reregistration

  XE "VI. Appendices:G. Batching of 2,4-DB and 2,4-DB-DMAS Products for
Acute Toxicity Requirements"

The Agency will complete the batching at a later date.Appendix H.  List
of All Registrants Sent the Data Call-In

A list of registrants sent the data call-in will be posted at a later
date.Appendix I.  	List of Available Related Documents and
Electronically Available Forms  XE "VI. Appendices:I. List of Available
Related Documents and Electronically Available Forms"

Pesticide Registration Forms are available at the following EPA internet
site:

    HYPERLINK "http://www.epa.gov/opprd001/forms/"
http://www.epa.gov/opprd001/forms/ 	.

Pesticide Registration Forms (These forms are in PDF format and require
the Acrobat reader)

Instructions

1.	Print out and complete the forms.  (Note: Form numbers that are
bolded can be filled out on your computer then printed.)

2.	The completed form(s) should be submitted in hardcopy in accord with
the existing policy.

3.	Mail the forms, along with any additional documents necessary to
comply with EPA regulations covering your request, to the address below
for the Document Processing Desk.

DO NOT fax or e-mail any form containing ‘Confidential Business
Information’ or ‘Sensitive Information.’

	If you have any problems accessing these forms, please contact Nicole
Williams at<PHONE_NUMBER> or by e-mail at   HYPERLINK
<EMAIL_ADDRESS><EMAIL_ADDRESS>.

The following Agency Pesticide Registration Forms are currently
available via the internet at the following locations:

8570-1	 Application for Pesticide Registration/Amendment	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-1.pdf"
http://www.epa.gov/opprd001/forms/8570-1.pdf

8570-4	Confidential Statement of Formula	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-4.pdf"
http://www.epa.gov/opprd001/forms/8570-4.pdf

8570-5	Notice of Supplemental Registration of Distribution of a
Registered Pesticide Product 	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-5.pdf"
http://www.epa.gov/opprd001/forms/8570-5.pdf

8570-17	 Application for an Experimental Use Permit	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-17.pdf"
http://www.epa.gov/opprd001/forms/8570-17.pdf

8570-25	 Application for/Notification of State Registration of a
Pesticide To Meet a Special Local Need 	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-25.pdf"
http://www.epa.gov/opprd001/forms/8570-25.pdf

8570-27	 Formulator’s Exemption Statement	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-27.pdf"
http://www.epa.gov/opprd001/forms/8570-27.pdf

8570-28	 Certification of Compliance with Data Gap Procedures
HYPERLINK "http://www.epa.gov/opprd001/forms/8570-28.pdf"
http://www.epa.gov/opprd001/forms/8570-28.pdf

8570-30	 Pesticide Registration Maintenance Fee Filing 	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-30.pdf"
http://www.epa.gov/opprd001/forms/8570-30.pdf

8570-32	 Certification of Attempt to Enter into an Agreement with other
Registrants for Development of Data 	    HYPERLINK
"http://www.epa.gov/opprd001/forms/8570-32.pdf"
http://www.epa.gov/opprd001/forms/8570-32.pdf

8570-34	 Certification with Respect to Citations of Data (in PR Notice
98-5)	    HYPERLINK "http://www.epa.gov/opppmsd1/PR_Notices/pr98-5.pdf"
http://www.epa.gov/opppmsd1/PR_Notices/pr98-5.pdf

8570-35	Data Matrix  (in PR Notice 98-5)	    HYPERLINK
"http://www.epa.gov/opppmsd1/PR_Notices/pr98-5.pdf"
http://www.epa.gov/opppmsd1/PR_Notices/pr98-5.pdf

8570-36	Summary of the Physical/Chemical Properties  (in PR Notice 98-1)
    HYPERLINK "http://www.epa.gov/opppmsd1/PR_Notices/pr98-1.pdf"
http://www.epa.gov/opppmsd1/PR_Notices/pr98-1.pdf

8570-37	 Self-Certification Statement for the Physical/Chemical
Properties  (in PR Notice 98-1)	    HYPERLINK
"http://www.epa.gov/opppmsd1/PR_Notices/pr98-1.pdf"
http://www.epa.gov/opppmsd1/PR_Notices/pr98-1.pdf

Pesticide Registration Kit

    HYPERLINK "http://www.epa.gov"
www.epa.gov/pesticides/registrationkit/ .

Dear Registrant:

	For your convenience, we have assembled an online registration kit that
contains the following pertinent forms and information needed to
register a pesticide product with the U.S.  Environmental Protection
Agency’s Office of Pesticide Programs (OPP):

1.	The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and
the Federal Food, Drug and Cosmetic Act (FFDCA) as Amended by the Food
Quality Protection Act (FQPA) of 1996.

	2.	Pesticide Registration (PR) Notices

		a.	83-3 Label Improvement Program—Storage and Disposal
Statements

		b.	84-1 Clarification of Label Improvement Program

		c.	86-5 Standard Format for Data Submitted under FIFRA

d.	87-1 Label Improvement Program for Pesticides Applied through
Irrigation Systems (Chemigation)

		e.	87-6 Inert Ingredients in Pesticide Products Policy Statement

f.	90-1 Inert Ingredients in Pesticide Products; Revised Policy
Statement

g.	95-2 Notifications, Non-notifications, and Minor Formulation
Amendments

h.	98-1 Self Certification of Product Chemistry Data with Attachments
(This document is in PDF format and requires the Acrobat reader.)

Other PR Notices can be found at     HYPERLINK
"http://www.epa.gov/opppmsd1/PR_Notices"
http://www.epa.gov/opppmsd1/PR_Notices .

3.	Pesticide Product Registration Application Forms (These forms are in
PDF format and will require the Acrobat reader.)

a.	EPA Form No.  8570-1, Application for Pesticide
Registration/Amendment

		b.	EPA Form No.  8570-4, Confidential Statement of Formula

		c.	EPA Form No.  8570-27, Formulator’s Exemption Statement

		d.	EPA Form No.  8570-34, Certification with Respect to Citations of
	Data

		e.	EPA Form No.  8570-35, Data Matrix

4.	General Pesticide Information (Some of these forms are in PDF format
and will require the Acrobat reader.)

		a.	Registration Division Personnel Contact List

b.	Biopesticides and Pollution Prevention Division (BPPD) Contacts

		c.	Antimicrobials Division Organizational Structure/Contact List

d.	53 F.R.  15952, Pesticide Registration Procedures; Pesticide Data
Requirements (PDF format)

e.  	40 CFR Part 156, Labeling Requirements for Pesticides and Devices
(PDF format)

		f.  	40 CFR Part 158, Data Requirements for Registration (PDF
format)

g.  	50 F.R.  48833, Disclosure of Reviews of Pesticide Data (November
27, 1985)

Before submitting your application for registration, you may wish to
consult some additional sources of information.  These include:

	1.	The Office of Pesticide Programs’ Web Site

2.	The booklet “General Information on Applying for Registration of
Pesticides in the United States”, PB92-221811, available through the
National Technical Information Service (NTIS) at the following address:

			National Technical Information Service (NTIS)

			5285 Port Royal Road

			Springfield, VA 22161

The telephone number for NTIS is<PHONE_NUMBER>.  Please note that EPA
is currently in the process of updating this booklet to reflect the
changes in the registration program resulting from the passage of the
FQPA and the reorganization of the Office of Pesticide Programs.  We
anticipate that this publication will become available during the Fall
of 1998.

3.	The National Pesticide Information Retrieval System (NPIRS) of Purdue
University’s Center for Environmental and Regulatory Information
Systems.  This service does charge a fee for subscriptions and custom
searches.  You can contact NPIRS by telephone at<PHONE_NUMBER> or
through their Web site.

4.	The National Pesticide Telecommunications Network (NPTN) can provide
information on active ingredients, uses, toxicology, and chemistry of
pesticides.  You can contact NPTN by telephone at<PHONE_NUMBER> or
through their Web site: ace.orst.edu/info/nptn.

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萏֠萑ﴰ葞֠葠ﴰ摧⸎üሀlowing entries to be completed by OPP:

			Date of receipt

			EPA identifying number

			Product Manager assignment

Other identifying information may be included by the applicant to link
the acknowledgment of receipt to the specific application submitted.
EPA will stamp the date of receipt and provide the EPA identifying File
Symbol or petition number for the new submission.  The identifying
number should be used whenever you contact the Agency concerning an
application for registration, experimental use permit, or tolerance
petition. To assist us in ensuring that all data you have submitted for
the chemical are properly coded and assigned to your company, please
include a list of all synonyms, common and trade names, company
experimental codes, and other names which identify the chemical
(including “blind” codes used when a sample was submitted for
testing by commercial or academic facilities).  Please provide a CAS
number if one has been assigned.

 The Agency is making this statement because triclosan and triclosan
transformation products are being detected in various environmental
components (see Revised Environmental Fate Science Chapter for the
Triclosan Reregistration Eligibility Decision (RED) Document, dated
September 11, 2008).

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[Federal Register: September 16, 2009 (Volume 74, Number 178)]
[Notices]
[Page 47578-47581]
[DOCID:fr16se09-55]

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ENVIRONMENTAL PROTECTION AGENCY

[EPA-HQ-OPP-2009-0687; FRL-8435-9]

FIFRA Scientific Advisory Panel; Notice of Public Meeting

 AGENCY: Environmental Protection Agency (EPA).

 ACTION: Notice.

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 SUMMARY: There will be a 4-day meeting of the Federal Insecticide,
Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP) to
consider and review scientific issues associated with field
volatilization of conventional pesticides.

 DATES: The meeting will be held on December 1-4, 2009, from 9 a.m. to
approximately 5:30 p.m, Eastern Time.
    Comments. The Agency encourages that written comments be submitted
by November 23, 2009 and requests for oral comments be submitted by
November 27, 2009. However, written comments and requests to make oral
comments may be submitted until the date of the meeting, but anyone
submitting written comments after November 23, 2009 should contact the
Designated Federal Official (DFO) listed under FOR FURTHER INFORMATION
CONTACT. For additional instructions, see Unit I.C. of the
SUPPLEMENTARY INFORMATION.
    Nominations. Nominations of candidates to serve as ad hoc members
of FIFRA SAP for this meeting should be provided on or before September
30, 2009.
    Special accommodations. For information on access or services for
individuals with disabilities, and to request accommodation of a
disability, please contact the DFO listed under FOR FURTHER INFORMATION
CONTACT at least 10 days prior to the meeting to give EPA as much time
as possible to process your request.

ADDRESSES:  The meeting will be held at the Environmental Protection
Agency, Conference Center, Lobby Level, One Potomac Yard (South Bldg.),
2777 S. Crystal Dr., Arlington, VA 22202.
    Comments. Submit your comments, identified by docket identification
(ID) number EPA-HQ-OPP-2009-0687, by one of the following methods:
      Federal eRulemaking Portal: http://www.regulations.gov.
Follow the on-line instructions for submitting comments.
      Mail: Office of Pesticide Programs (OPP) Regulatory
Public Docket (7502P), Environmental Protection Agency, 1200
Pennsylvania Ave., NW., Washington, DC 20460-0001.
     Delivery: OPP Regulatory Public Docket (7502P),
Environmental Protection Agency, Rm. S-4400, One Potomac Yard (South
Bldg.), 2777 S. Crystal Dr., Arlington, VA. Deliveries are only
accepted during the Docket Facility's normal hours of operation 8:30
a.m. to 4 p.m., Monday through Friday, excluding legal holidays.
Special arrangements should be made for deliveries of boxed
information. The Docket Facility telephone number is<PHONE_NUMBER>.
    Instructions. Direct your comments to docket ID number EPA-HQ-OPP-
2009-0687. If your comments contain any information that you consider
to be CBI or otherwise protected, please contact the DFO listed under
FOR FURTHER INFORMATION CONTACT to obtain special instructions before
submitting your comments. EPA's policy is that all comments received
will be included in the docket without change and may be made available
on-line at http://www.regulations.gov, including any personal
information provided, unless the comment includes information claimed
to be Confidential Business Information (CBI) or other information
whose disclosure is restricted by statute. Do not submit information
that you consider to be CBI or otherwise protected through
regulations.gov or e-mail. The regulations.gov website is an
``anonymous access'' system, which means EPA will not know your
identity or contact information unless you provide it in the body of
your comment. If you send an e-mail comment directly to EPA without
going through regulations.gov, your e-mail address will be
automatically captured and included as part of the comment that is
placed in the docket and made available on the Internet. If you submit
an electronic comment, EPA recommends that you include your name and
other contact information in the body of your comment and with any disk
or CD-ROM you submit. If EPA cannot read your

comment due to technical difficulties and cannot contact you for
clarification, EPA may not be able to consider your comment. Electronic
files should avoid the use of special characters, any form of
encryption, and be free of any defects or viruses.
    Docket: All documents in the docket are listed in the docket index
available at http://www.regulations.gov. Although listed in the index,
some information is not publicly available, e.g., CBI or other
information whose disclosure is restricted by statute. Certain other
material, such as copyrighted material, is not placed on the Internet
and will be publicly available only in hard copy form. Publicly
available docket materials are available either in the electronic
docket at http://www.regulations.gov, or, if only available in hard
copy, at the OPP Regulatory Public Docket in Rm. S-4400, One Potomac
Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA. The hours of
operation of this Docket Facility are from 8:30 a.m. to 4 p.m., Monday
through Friday, excluding legal holidays. The Docket Facility telephone
number is<PHONE_NUMBER>.
    Nominations, requests to present oral comments, and requests for
special accommodations. Submit nominations to serve as ad hoc members
of FIFRA SAP, requests for special seating accommodations, or requests
to present oral comments to the DFO listed under FOR FURTHER
INFORMATION CONTACT.

 FOR FURTHER INFORMATION CONTACT:  Sharlene Matten, DFO, Office of
Science Coordination and Policy (7201M), Environmental Protection
Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460-0001;
telephone number:<PHONE_NUMBER>; fax number:<PHONE_NUMBER>; e-mail
addresses<EMAIL_ADDRESS>
 SUPPLEMENTARY INFORMATION:

I. General Information

A. Does this Action Apply to Me?

    This action is directed to the public in general. This action may,
however, be of interest to persons who are or may be required to
conduct testing of chemical substances under the Federal Food, Drug,
and Cosmetic Act (FFDCA), FIFRA, and the Food Quality Protection Act of
1996 (FQPA). Since other entities may also be interested, the Agency
has not attempted to describe all the specific entities that may be
affected by this action. If you have any questions regarding the
applicability of this action to a particular entity, consult the DFO
listed under FOR FURTHER INFORMATION CONTACT.

B. What Should I Consider as I Prepare My Comments for EPA?

    When submitting comments, remember to:
    1. Identify the document by docket ID number and other identifying
information (subject heading, Federal Register date and page number).
     2. Follow directions. The Agency may ask you to respond to
specific questions or organize comments by referencing a Code of
Federal Regulations (CFR) part or section number.
    3. Explain why you agree or disagree; suggest alternatives and
substitute language for your requested changes.
    4. Describe any assumptions and provide any technical information
and/or data that you used.
    5. If you estimate potential costs or burdens, explain how you
arrived at your estimate in sufficient detail to allow for it to be
reproduced.
    6. Provide specific examples to illustrate your concerns and
suggest alternatives.
    7. Explain your views as clearly as possible, avoiding the use of
profanity or personal threats.
    8. Make sure to submit your comments by the comment period deadline
identified.

C. How May I Participate in this Meeting?

    You may participate in this meeting by following the instructions
in this unit. To ensure proper receipt by EPA, it is imperative that
you identify docket ID number EPA-HQ-OPP-2009-0687 in the subject line
on the first page of your request.
    1. Written comments. The Agency encourages that written comments be
submitted, using the instructions in ADDRESSES, no later than November
23, 2009, to provide FIFRA SAP the time necessary to consider and
review the written comments. Written comments are accepted until the
date of the meeting, but anyone submitting written comments after
November 23, 2009 should contact the DFO listed under FOR FURTHER
INFORMATION CONTACT. Anyone submitting written comments at the meeting
should bring 30 copies for distribution to FIFRA SAP.
    2. Oral comments. The Agency encourages that each individual or
group wishing to make brief oral comments to FIFRA SAP submit their
request to the DFO listed under FOR FURTHER INFORMATION CONTACT no
later than November 27, 2009, in order to be included on the meeting
agenda. Requests to present oral comments will be accepted until the
date of the meeting and, to the extent that time permits, the Chair of
FIFRA SAP may permit the presentation of oral comments at the meeting
by interested persons who have not previously requested time. The
request should identify the name of the individual making the
presentation, the organization (if any) the individual will represent,
and any requirements for audiovisual equipment (e.g., overhead
projector, 35 mm projector, chalkboard). Oral comments before FIFRA SAP
are limited to approximately 5 minutes unless prior arrangements have
been made. In addition, each speaker should bring 30 copies of his or
her comments and presentation slides for distribution to the FIFRA SAP
at the meeting.
    3. Seating at the meeting. Seating at the meeting will be open and
on a first-come basis.
    4. Request for nominations to serve as ad hoc members of FIFRA SAP
for this meeting. As part of a broader process for developing a pool of
candidates for each meeting, FIFRA SAP staff routinely solicits the
stakeholder community for nominations of prospective candidates for
service as ad hoc members of FIFRA SAP. Any interested person or
organization may nominate qualified individuals to be considered as
prospective candidates for a specific meeting. Individuals nominated
for this meeting should have expertise in one or more of the following
areas: Inhalation Toxicity, Pesticide Exposure and Risk Assessment,
Pesticide Fate and Transport, and Environmental Air Modeling. Nominees
should be scientists who have sufficient professional qualifications,
including training and experience, to be capable of providing expert
comments on the scientific issues for this meeting. Nominees should be
identified by name, occupation, position, address, and telephone
number. Nominations should be provided to the DFO listed under FOR
FURTHER INFORMATION CONTACT on or before September 30, 2009. The Agency
will consider all nominations of prospective candidates for this
meeting that are received on or before this date. However, final
selection of ad hoc members for this meeting is a discretionary
function of the Agency.
     The selection of scientists to serve on FIFRA SAP is based on the
function of the panel and the expertise needed to address the Agency's
charge to the panel. No interested scientists shall be ineligible to
serve by reason of their membership on any other advisory committee to
a Federal department or Agency or their employment by a Federal
department or agency except the EPA. Other factors considered during
the selection process include availability of the potential panel

member to fully participate in the panel's reviews, absence of any
conflicts of interest or appearance of lack of impartiality,
independence with respect to the matters under review, and lack of
bias. Although, financial conflicts of interest, the appearance of lack
of impartiality, lack of independence, and bias may result in
disqualification, the absence of such concerns does not assure that a
candidate will be selected to serve on FIFRA SAP. Numerous qualified
candidates are identified for each panel. Therefore, selection
decisions involve carefully weighing a number of factors including the
candidates' areas of expertise and professional qualifications and
achieving an overall balance of different scientific perspectives on
the panel. In order to have the collective breadth of experience needed
to address the Agency's charge for this meeting, the Agency anticipates
selecting approximately 10-12 ad hoc scientists.
    FIFRA SAP members are subject to the provisions of 5 CFR part 2634,
Executive Branch Financial Disclosure, as supplemented by the EPA in 5
CFR part 6401. In anticipation of this requirement, prospective
candidates for service on the FIFRA SAP will be asked to submit
confidential financial information which shall fully disclose, among
other financial interests, the candidate's employment, stocks and
bonds, and where applicable, sources of research support. The EPA will
evaluate the candidates financial disclosure form to assess whether
there are financial conflicts of interest, appearance of a lack of
impartiality or any prior involvement with the development of the
documents under consideration (including previous scientific peer
review) before the candidate is considered further for service on FIFRA
SAP. Those who are selected from the pool of prospective candidates
will be asked to attend the public meetings and to participate in the
discussion of key issues and assumptions at these meetings. In
addition, they will be asked to review and to help finalize the meeting
minutes. The list of FIFRA SAP members participating at this meeting
will be posted on the FIFRA SAP website at http://epa.gov/scipoly/sap
or may be obtained from the OPP Regulatory Public Docket at http://
www.regulations.gov.

 II. Background

 A. Purpose of FIFRA SAP

    FIFRA SAP serves as the primary scientific peer review mechanism of
EPA's Office of Prevention, Pesticides and Toxic Substances (OPPTS) and
is structured to provide scientific advice, information and
recommendations to the EPA Administrator on pesticides and pesticide-
related issues as to the impact of regulatory actions on health and the
environment. FIFRA SAP is a Federal advisory committee established in
1975 under FIFRA that operates in accordance with requirements of the
Federal Advisory Committee Act. FIFRA SAP is composed of a permanent
panel consisting of seven members who are appointed by the EPA
Administrator from nominees provided by the National Institutes of
Health and the National Science Foundation. FIFRA, as amended by FQPA,
established a Science Review Board consisting of at least 60 scientists
who are available to the SAP on an ad hoc basis to assist in reviews
conducted by the SAP. As a peer review mechanism, FIFRA SAP provides
comments, evaluations and recommendations to improve the effectiveness
and quality of analyses made by Agency scientists. Members of FIFRA SAP
are scientists who have sufficient professional qualifications,
including training and experience, to provide expert advice and
recommendation to the Agency.

 B. Public Meeting

    The Standard Operating Procedures (SOPs) for Residential Exposure
Assessment is a set of standard instructions for estimating residential
exposure resulting from various direct, labeled pesticide uses.
Residential individuals can also be potentially exposed via indirect
exposure to conventional pesticides. These types of exposures can occur
through a variety of means including field volatilization of
conventional pesticides, spray drift, and transport of pesticide
residues to the residence (``take-home'' exposure). Methodologies for
assessing indirect exposures are not currently included in the
Residential SOPs.
     Recently, the Agency has been exploring the development of an
approach for assessing inhalation exposure resulting from the field
volatilization of conventional pesticides. The following issues have
been identified as key elements for this exposure scenario:
     Use of the Agency's Reference Concentration (RfC)
methodology to calculate Human Equivalent Concentrations (HECs) when
inhalation toxicity studies are available.
     Comparison of the use of inhalation vs. oral toxicity
studies.
     Development of a tiered approach to determine the level of
complexity and refinement needed to estimate exposure, including:
     a. Use of available air monitoring data: California Air Resource
Board (CARB), Pesticide Action Network - North America (PANNA), and
other data sources.
     b. Development of a volatilization screening tool to estimate flux
based on physical/chemical properties of a pesticide.
     c. Use of more refined soil models to estimate flux.
     d. Use of air models to estimate concentrations around a treated
field.
     EPA's goal is to have a set of procedures that include transparent
methodologies and data inputs that will guide the assessment of
bystander exposure resulting from field volatilization of conventional
pesticides in a straight-forward and user-friendly fashion. The Agency
is seeking comment from the Panel on the adequacy of the toxicological
and exposure assessment methodologies; the applicability, analysis, and
use of available air monitoring data; the strengths and limitations of
the models being considered by the Agency for predicting flux of
conventional pesticides; and the overall presentation of the issues
related to field volatilization of conventional pesticides with respect
to the overall clarity and transparency of the science.

C. FIFRA SAP Documents and Meeting Minutes

    EPA's background paper, related supporting materials, charge/
questions to FIFRA SAP, FIFRA SAP composition (i.e., members and ad hoc
members for this meeting), and the meeting agenda will be available by
November 16, 2009. In addition, the Agency may provide additional
background documents as the materials become available. You may obtain
electronic copies of these documents, and certain other related
documents that might be available electronically, at http://
www.regulations.gov and the FIFRA SAP homepage at http://www.epa.gov/
scipoly/sap.
    FIFRA SAP will prepare meeting minutes summarizing its
recommendations to the Agency approximately 90 days after the meeting.
The meeting minutes will be posted on the FIFRA SAP website or may be
obtained from the OPP Regulatory Public Docket at http://
www.regulations.gov.

List of Subjects

    Environmental protection, Pesticides and pests.

    Dated: September 10, 2009.
 Steven M. Knott,
Acting Director, Office of Science Coordination and Policy.
[FR Doc. E9-22296 Filed 9-15-09; 8:45 a.m.]

BILLING CODE 6560-50-S


[Federal Register: April 14, 2006 (Volume 71, Number 72)]
[Proposed Rules]
[Page 19470-19471]
[DOCID:fr14ap06-17]

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ENVIRONMENTAL PROTECTION AGENCY

40 CFR Part 271

[FRL-8158-3]

Washington: Final Authorization of State Hazardous Waste
Management Program Revisions

AGENCY: Environmental Protection Agency (EPA).

ACTION: Proposed rule.

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SUMMARY: During a review of Washington's regulations, EPA identified a
variety of State-initiated changes to Washington's hazardous waste
program under the Resource Conservation and Recovery Act, as amended,
(RCRA) for which the State had not previously sought authorization. EPA
proposes to authorize the State for the program changes. In the ``Rules
and Regulations'' section of this Federal Register, EPA is authorizing
the revisions by an immediate final rule. EPA did not make a proposal
prior to the immediate final rule because we believe this action is not
controversial and do not expect comments that oppose it. We have
explained the reasons for this authorization in the preamble to the
immediate final rule. Unless we receive written comments that oppose
this authorization during the comment period, the immediate final rule
will become effective on the date it establishes, and we will not take
further action on this proposal. If we receive comments that oppose
this authorization, EPA will publish a document in the Federal Register
withdrawing the immediate final rule before it takes effect. EPA will
then address public comments in a later final rule based on this
proposal. If we receive comments that oppose only the authorization of
a particular change to the State hazardous waste program, we will
withdraw that part of the immediate final rule. However, the
authorization of program changes that are not opposed by any comments
will become effective on the date established in the immediate final
rule. A Federal Register withdrawal document will specify which part of
the authorization will become effective and which part is being
withdrawn. EPA may not provide further opportunity for comment. Any
parties interested in commenting on this action must do so at this
time. EPA is also proposing to make corrections to the table included
in the authorization Federal Register document for Washington published
on October 12, 1999.

DATES: Send your written comments by May 15, 2006.

ADDRESSES: Submit your comments, identified by EPA-R10-RCRA-2006-0087
by one of the following methods:
    1. Federal eRulemaking Portal: http://www.regulations.gov. Follow

the on-line instructions for submitting comments.
    2. E-mail<EMAIL_ADDRESS>    3. Fax:<PHONE_NUMBER>.
    4. Mail: Nina Kocourek, U.S. EPA, Region 10, Office of Air, Waste
and Toxics, 1200 Sixth Avenue, Mail Stop AWTB122, Seattle, Washington
98101.
    Instructions: Direct your comments to EPA-10-RCRA-2006-0087. EPA's
policy is that all comments received will be included in the public
file without change and may be made available online at http://www.regulations.gov
, including any personal information provided,

unless the comment includes information claimed to be Confidential
Business Information (CBI) or other information whose disclosure is
restricted by statute. Do not submit information that you consider to
be CBI or otherwise protected through http://www.regulations.gov or e-mail. The http://www.regulations.gov Web site is an ``anonymous

access'' system which means that EPA will not know your identity or
contact information unless you provide it in the body of your comment.
If you send an e-mail comment directly to EPA without going through
http://www.regulations.gov, your e-mail address will be automatically

captured and included as part of the comment that is placed in the
public file and made available on the Internet. If you submit an
electronic comment, EPA recommends that you include your name and other
contact information in the body of your comment and with any disk or
CD-ROM you submit. If EPA cannot read your comment due to technical
difficulties and cannot contact you for clarification, EPA may not be
able to consider your comment. Electronic files should avoid the use of
special characters and any form of encryption, and be free of any
defects or viruses. For additional information about EPA's public
docket visit the EPA Docket Center homepage at http://www.epa.gov/epahome/dockets.htm
.

    Docket: All documents in the docket are listed in the http://www.regulations.gov
 index. Although listed in the index, some

information is not publicly available, e.g., CBI or other information
whose disclosure is restricted by statute. Certain other material, such
as copyrighted material, will be publicly available only in hard copy.
Publicly available docket materials are available either electronically
in http://www.regulations.gov or in hard copy during normal business

hours at the U.S. Environmental Protection Agency, Region 10 Library,
1200 Sixth Avenue, Seattle, Washington, 98101. This Docket Facility is
open to the public from 9 to 11:30 a.m. and from 1 to 4 p.m. Monday
through Friday, excluding legal holidays. The library telephone number
is<PHONE_NUMBER>. Additionally, hard copies are available from the
Washington Department of Ecology, 300 Desmond Drive, Lacey, WA 98503,
contact, Patricia Hervieux at<PHONE_NUMBER>.

FOR FURTHER INFORMATION CONTACT: Nina Kocourek, U.S. EPA, Region 10,
Office of Air, Waste and Toxics, 1200 Sixth Avenue, Mail Stop AWT-122,
Seattle, Washington 9810, phone number:<PHONE_NUMBER>, e-mail:
<EMAIL_ADDRESS>or Patricia Hervieux, Washington Department of

Ecology, 300 Desmond Drive, Lacey, WA 98503; phone number: (360) 407-
6756, e-mail<EMAIL_ADDRESS>
SUPPLEMENTARY INFORMATION: For additional information, please see the
immediate final rule published in the ``Rules and Regulations'' section
of this Federal Register.

List of Subjects in 40 CFR Part 271

    Environmental protection, Administrative practice and procedure,
Confidential business information, Hazardous materials transportation,
Hazardous waste, Indians-lands, Intergovernmental relations, Penalties,
Reporting and recordkeeping requirements.

    Authority: This action is issued under the authority of sections
2002(a), 3006 and 7004(b) of the Solid Waste Disposal Act, as
amended, 42 U.S.C. 6912(a), 6926, 6974(b).

    Dated: April 5, 2006.
L. Michael Bogert,
Regional Administrator, EPA Region 10.
[FR Doc. 06-3546 Filed 4-13-06; 8:45 am]

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