o r s   f o r   t h e   p r o d u c t i o n   o f p h o t o v o l t a i c   c e l l s .     S o l a r   C e l l s   2 8 ,   2 0 9 - 2 2 2 . M c C o n n e l l ,   E . E . ,   S o l l e v e l d ,   H . A . ,   S w e n b e r g ,   J . A . ,   a n d B o o r m a n ,   G . A .   ( 1 9 8 6 ) .     G u i d e l i n e s   f o r   c o m b i n i n g   n e o - p l a s m s   f o r   e v a l u a t i o n   o f   r o d e n t   c a r c i n o g e n e s i s   s t u d i e s . J N C I   7 6 ,   2 8 3 - 2 8 9 . M c C o r d ,   C . P . ,   M e e k ,   S . F . ,   H a r r o l d ,   G . C . ,   a n d H e u s s n e r ,   C . E .   ( 1 9 4 2 ) .     T h e   p h y s i o l o g i c   p r o p e r t i e s   o f i n d i u m   a n d   i t s   c o m p o u n d s .     J .   I n d .   H y g .   T o x i c o l .   2 4 , 2 4 3 - 2 5 4 . M a c G r e g o r ,   J . T . ,   W e h r ,   C . M . ,   H e n i k a ,   P . R . ,   a n d S h e l b y ,   M . D .   ( 1 9 9 0 ) .     T h e   i n   v i v o   e r y t h r o c y t e   m i c r o - n u c l e u s   t e s t :     M e a s u r e m e n t   a t   s t e a d y   s t a t e   i n c r e a s e s a s s a y   e f f i c i e n c y   a n d   p e r m i t s   i n t e g r a t i o n   w i t h   t o x i c i t y s t u d i e s .     F u n d a m .   A p p l .   T o x i c o l .   1 4 ,   5 1 3 - 5 2 2 . M a r o n p o t ,   R . R . ,   a n d   B o o r m a n ,   G . A .   ( 1 9 8 2 ) . I n t e r p r e t a t i o n   o f   r o d e n t   h e p a t o c e l l u l a r   p r o l i f e r a t i v e a l t e r a t i o n s   a n d   h e p a t o c e l l u l a r   t u m o r s   i n   c h e m i c a l   s a f e t y a s s e s s m e n t .     T o x i c o l .   P a t h o l .   1 0 ,   7 1 - 8 0 . T h e   M e r c k   I n d e x   ( 1 9 9 6 ) .     1 2 t h   e d .   ( S .   B u d a v a r i ,   E d . ) , p .   4 9 9 4 .     M e r c k   a n d   C o m p a n y ,   W h i t e h o u s e   S t a t i o n , N J . M o r r i s o n ,   D . F .   ( 1 9 7 6 ) .     M u l t i v a r i a t e   S t a t i s t i c a l M e t h o d s ,   2 n d   e d . ,   p p .   1 7 0 - 1 7 9 .     M c G r a w - H i l l   B o o k C o m p a n y ,   N e w   Y o r k . M o r r o w ,   P . E .   ( 1 9 8 6 ) .     T h e   s e t t i n g   o f   p a r t i c u l a t e e x p o s u r e   l e v e l s   f o r   c h r o n i c   i n h a l a t i o n   t o x i c i t y   s t u d i e s . J .   A m .   C o l l .   T o x i c o l .   6 ,   5 3 3 - 5 4 4 . M o s o v s k y ,   J . A . ,   R a i n e r ,   D . ,   A s o m ,   M . T . ,   a n d Q u i n n ,   W . E .   ( 1 9 9 2 ) .     T r a n s i e n t   h y d r i d e   g e n e r a t i o n d u r i n g   I I I - V   s e m i c o n d u c t o r   p r o c e s s i n g .     A p p l .   O c c u p . E n v i r o n .   H y g .   7 ,   3 7 5 - 3 8 4 . N a k a j i m a ,   M . ,   T a k a h a s h i ,   H . ,   S a s a k i ,   M . ,   K o b a y a s h i , Y . ,   A w a n o ,   T . ,   I r i e ,   D . ,   S a k e m i ,   K . ,   O h n o ,   Y . ,   a n d U s a m i ,   M .   ( 1 9 9 8 ) .     D e v e l o p m e n t a l   t o x i c i t y   o f   i n d i u m c h l o r i d e   b y   i n t r a v e n o u s   o r   o r a l   a d m i n i s t r a t i o n   i n   r a t s . T e r a t o g e n e s i s   C a r c i n o g .   M u t a g e n .   1 8 ,   2 3 1 - 2 3 8 . N a k a j i m a ,   M . ,   S a s a k i ,   M . ,   K o b a y a s h i ,   Y . ,   O h n o ,   Y . , a n d   U s a m i ,   M .   ( 1 9 9 9 ) .     D e v e l o p m e n t a l   t o x i c i t y   o f i n d i u m   i n   c u l t u r e d   r a t   e m b r y o s .     T e r a t o g e n e s i s C a r c i n o g .   M u t a g e n .   1 9 ,   2 0 5 - 2 0 9 . N a t i o n a l   I n s t i t u t e   f o r   O c c u p a t i o n a l   S a f e t y   a n d   H e a l t h ( N I O S H )   ( 1 9 8 5 ) .     H a z a r d   A s s e s s m e n t   o f   t h e   E l e c t r o n i c C o m p o n e n t   M a n u f a c t u r i n g   I n d u s t r y .     U . S .   D e p a r t m e n t o f   H e a l t h   a n d   H u m a n   S e r v i c e s ,   P u b l i c   H e a l t h   S e r v i c e , C e n t e r s   f o r   D i s e a s e   C o n t r o l ,   C i n c i n n a t i . N a t i o n a l   I n s t i t u t e   f o r   O c c u p a t i o n a l   S a f e t y   a n d   H e a l t h ( N I O S H )   ( 1 9 9 7 ) .     N I O S H   p o c k e t   g u i d e   t o   c h e m i c a l h a z a r d s .     U . S .   D e p a r t m e n t   o f   H e a l t h   a n d   H u m a n S e r v i c e s ,   P u b l i c   H e a l t h   S e r v i c e ,   C e n t e r s   f o r   D i s e a s e C o n t r o l   a n d   P r e v e n t i o n ,   W a s h i n g t o n ,   D . C . N a t i o n a l   T o x i c o l o g y   P r o g r a m   ( N T P )   ( 1 9 8 7 ) . T e c h n i c a l   P r o t o c o l   f o r   S p e r m   M o r p h o l o g y   a n d   V a g i n a l C y t o l o g y   E v a l u a t i o n s   i n   T o x i c i t y   T e s t i n g   f o r   R a t s   a n d M i c e ,   1 0 / 3 1 / 8 2   v e r s i o n   ( u p d a t e d   D e c e m b e r   1 9 8 7 ) . R e s e a r c h   T r i a n g l e   P a r k ,   N C . 1 0 0 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 N a t i o n a l   T o x i c o l o g y   P r o g r a m   ( 1 9 9 3 ) .     T o x i c o l o g y   a n d C a r c i n o g e n e s i s   S t u d i e s   o f   T a l c   ( C A S   N o .   1 4 8 0 7 - 9 6 - 6 ) i n   F 3 4 4 / N   R a t s   a n d   B 6 C 3 F 1   M i c e   ( I n h a l a t i o n   S t u d i e s ) . T e c h n i c a l   R e p o r t   S e r i e s   N o .   4 2 1 .     N I H   P u b l i c a t i o n   N o . 9 3 - 3 1 5 2 .     U . S .   D e p a r t m e n t   o f   H e a l t h   a n d   H u m a n S e r v i c e s ,   P u b l i c   H e a l t h   S e r v i c e ,   N a t i o n a l   I n s t i t u t e s   o f H e a l t h ,   R e s e a r c h   T r i a n g l e   P a r k ,   N C . N a t i o n a l   T o x i c o l o g y   P r o g r a m   ( 1 9 9 6 a ) .     T o x i c o l o g y a n d   C a r c i n o g e n e s i s   S t u d i e s   o f   N i c k e l   S u b s u l f i d e   ( C A S N o .   1 2 0 3 5 - 7 2 - 2 )   i n   F 3 4 4 / N   R a t s   a n d   B 6 C 3 F 1   M i c e ( I n h a l a t i o n   S t u d i e s ) .     T e c h n i c a l   R e p o r t   S e r i e s   N o .   4 5 3 . N I H   P u b l i c a t i o n   N o .   9 6 - 3 3 6 9 .     U . S .   D e p a r t m e n t   o f H e a l t h   a n d   H u m a n   S e r v i c e s ,   P u b l i c   H e a l t h   S e r v i c e , N a t i o n a l   I n s t i t u t e s   o f   H e a l t h ,   R e s e a r c h   T r i a n g l e   P a r k , N C . N a t i o n a l   T o x i c o l o g y   P r o g r a m   ( 1 9 9 6 b ) .     T o x i c o l o g y a n d   C a r c i n o g e n e s i s   S t u d i e s   o f   N i c k e l   O x i d e   ( C A S   N o . 1 3 1 3 - 9 9 - 1 )   i n   F 3 4 4 / N   R a t s   a n d   B 6 C 3 F 1   M i c e   ( I n h a l a - t i o n   S t u d i e s ) .     T e c h n i c a l   R e p o r t   S e r i e s   N o .   4 5 1 .     N I H P u b l i c a t i o n   N o .   9 6 - 3 3 6 7 .     U . S .   D e p a r t m e n t   o f   H e a l t h a n d   H u m a n   S e r v i c e s ,   P u b l i c   H e a l t h   S e r v i c e ,   N a t i o n a l I n s t i t u t e   o f   H e a l t h ,   R e s e a r c h   T r i a n g l e   P a r k ,   N C . N a t i o n a l   T o x i c o l o g y   P r o g r a m   ( 1 9 9 6 c ) .     T o x i c o l o g y a n d   C a r c i n o g e n e s i s   S t u d i e s   o f   N i c k e l   S u l f a t e H e x a h y d r a t e     ( C A S   N o .   1 0 1 0 1 - 9 7 - 0 )   i n   F 3 4 4 / N   R a t s a n d   B 6 C 3 F 1   M i c e   ( I n h a l a t i o n   S t u d i e s ) .     T e c h n i c a l R e p o r t   S e r i e s   N o .   4 5 4 .     N I H   P u b l i c a t i o n   N o .   9 6 - 3 3 7 0 . U . S .   D e p a r t m e n t   o f   H e a l t h   a n d   H u m a n   S e r v i c e s ,   P u b l i c H e a l t h   S e r v i c e ,   N a t i o n a l   I n s t i t u t e   o f   H e a l t h ,   R e s e a r c h T r i a n g l e   P a r k ,   N C . N a t i o n a l   T o x i c o l o g y   P r o g r a m   ( 1 9 9 8 ) .     T o x i c o l o g y   a n d C a r c i n o g e n e s i s   S t u d i e s   o f   C o b a l t   S u l f a t e   H e p t a h y d r a t e ( C A S   N o .   1 0 0 2 6 - 2 4 - 1 )   i n   F 3 4 4 / N   R a t s   a n d   B 6 C 3 F 1 M i c e   ( I n h a l a t i o n   S t u d i e s ) .     T e c h n i c a l   R e p o r t   S e r i e s N o .   4 7 1 .     N I H   P u b l i c a t i o n   N o .   9 8 - 3 9 6 1 .     U . S .   D e p a r t - m e n t   o f   H e a l t h   a n d   H u m a n   S e r v i c e s ,   P u b l i c   H e a l t h S e r v i c e ,   N a t i o n a l   I n s t i t u t e s   o f   H e a l t h ,   R e s e a r c h T r i a n g l e   P a r k ,   N C . N a t i o n a l   T o x i c o l o g y   P r o g r a m   ( 2 0 0 0 ) .     T o x i c o l o g y   a n d C a r c i n o g e n e s i s   S t u d i e s   o f   G a l l i u m   A r s e n i d e   ( C A S N o .   1 3 0 3 - 0 0 - 0 )   i n   F 3 4 4 / N   R a t s   a n d   B 6 C 3 F 1   M i c e ( I n h a l a t i o n   S t u d i e s ) .     T e c h n i c a l   R e p o r t   S e r i e s   N o .   4 9 2 . N I H   P u b l i c a t i o n   N o .   0 0 - 3 9 5 1 .     U . S .   D e p a r t m e n t   o f H e a l t h   a n d   H u m a n   S e r v i c e s ,   P u b l i c   H e a l t h   S e r v i c e , N a t i o n a l   I n s t i t u t e s   o f   H e a l t h ,   R e s e a r c h   T r i a n g l e   P a r k , N C . O d a ,   K .   ( 1 9 9 7 ) .     T o x i c i t y   o f   a   l o w   l e v e l   o f   i n d i u m p h o s p h i d e   ( I n P )   i n   r a t s   a f t e r   i n t r a t r a c h e a l   i n s t i l l a t i o n . I n d .   H e a l t h   3 5 ,   6 1 - 6 8 . P a t t y ’ s   I n d u s t r i a l   H y g i e n e   a n d   T o x i c o l o g y   ( 1 9 9 4 ) . 4 t h   e d .   ( G . D .   C l a y t o n   a n d   F . E .   C l a y t o n ,   E d s . ) ,   V o l .   2 C , p p .   2 0 3 2 - 2 0 3 8 .     J o h n   W i l e y   a n d   S o n s ,   N e w   Y o r k . P i e g o r s c h ,   W . W . ,   a n d   B a i l e r ,   A . J .   ( 1 9 9 7 ) .     S t a t i s t i c s   f o r E n v i r o n m e n t a l   B i o l o g y   a n d   T o x i c o l o g y ,   S e c t i o n   6 . 3 . 2 . , C h a p m a n   a n d   H a l l ,   L o n d o n . P o r t i e r ,   C . J . ,   a n d   B a i l e r ,   A . J .   ( 1 9 8 9 ) .     T e s t i n g   f o r i n c r e a s e d   c a r c i n o g e n i c i t y   u s i n g   a   s u r v i v a l - a d j u s t e d q u a n t a l   r e s p o n s e   t e s t .     F u n d a m .   A p p l .   T o x i c o l .   1 2 , 7 3 1 - 7 3 7 . P o r t i e r ,   C . J . ,   H e d g e s ,   J . C . ,   a n d   H o e l ,   D . G .   ( 1 9 8 6 ) . A g e - s p e c i f i c   m o d e l s   o f   m o r t a l i t y   a n d   t u m o r   o n s e t   f o r h i s t o r i c a l   c o n t r o l   a n i m a l s   i n   t h e   N a t i o n a l   T o x i c o l o g y P r o g r a m ’ s   c a r c i n o g e n i c i t y   e x p e r i m e n t s .     C a n c e r   R e s . 4 6 ,   4 3 7 2 - 4 3 7 8 . R a o ,   G . N .   ( 1 9 9 6 ) .     N e w   d i e t   ( N T P - 2 0 0 0 )   f o r   r a t s   i n   t h e N a t i o n a l   T o x i c o l o g y   P r o g r a m   t o x i c i t y   a n d   c a r c i n o - g e n i c i t y   s t u d i e s .     F u n d a m .   A p p l .   T o x i c o l .   3 2 ,   1 0 2 - 1 0 8 . R a o ,   G . N .   ( 1 9 9 7 ) .     N e w   n o n p u r i f i e d   d i e t   ( N T P - 2 0 0 0 ) f o r   r o d e n t s   i n   t h e   N a t i o n a l   T o x i c o l o g y   P r o g r a m ’ s t o x i c o l o g y   a n d   c a r c i n o g e n e s i s   s t u d i e s .     J .   N u t r .   1 2 7 , 8 4 2 S - 8 4 6 S . S c a n s e t t i ,   G .   ( 1 9 9 2 ) .     E x p o s u r e   t o   m e t a l s   t h a t   h a v e r e c e n t l y   c o m e   i n t o   u s e .     S c i .   T o t a l   E n v i r o n .   1 2 0 ,   8 5 - 9 1 . I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 0 1 S h i r l e y ,   E .   ( 1 9 7 7 ) .     A   n o n - p a r a m e t r i c   e q u i v a l e n t   o f W i l l i a m s ’   t e s t   f o r   c o n t r a s t i n g   i n c r e a s i n g   d o s e   l e v e l s   o f a   t r e a t m e n t .     B i o m e t r i c s   3 3 ,   3 8 6 - 3 8 9 . S m i t h ,   I . C . ,   C a r s o n ,   B . L . ,   a n d   H o f f m e i s t e r ,   F . ,   E d s . ( 1 9 7 8 ) .     V o l u m e   5 – I n d i u m .     A n   a p p r a i s a l   o f   e n v i r o n - m e n t a l   e x p o s u r e .     I n   T r a c e   M e t a l s   i n   t h e   E n v i r o n m e n t . A n n   A r b o r   S c i e n c e   P u b l i s h e r s ,   I n c . ,     A n n   A r b o r ,   M I . T a n a k a ,   A . ,   H i s a n a g a ,   A . ,   H i r a t a ,   M . ,   O m u r a ,   M . , M a k i t a ,   Y . ,   I n o u e ,   N . ,   a n d   I s h i n i s h i ,   N .   ( 1 9 9 6 ) . C h r o n i c   t o x i c i t y   o f   i n d i u m   a r s e n i d e   a n d   i n d i u m p h o s p h i d e   t o   t h e   l u n g s   o f   h a m s t e r s .     F u k u o k a   A c t a M e d .   8 7 ,   1 0 8 - 1 1 5 . T a r o n e ,   R . E .   ( 1 9 7 5 ) .     T e s t s   f o r   t r e n d   i n   l i f e   t a b l e a n a l y s i s .     B i o m e t r i k a   6 2 ,   6 7 9 - 6 8 2 . T i c e ,   R . R . ,   E r e x s o n ,   G . L . ,   H i l l i a r d ,   C . J . ,   H u s t o n ,   J . L . , B o e h m ,   R . M . ,   G u l a t i ,   D . ,   a n d   S h e l b y ,   M . D .   ( 1 9 9 0 ) . E f f e c t   o f   t r e a t m e n t   p r o t o c o l   a n d   s a m p l e   t i m e   o n   t h e f r e q u e n c i e s   o f   m i c r o n u c l e a t e d   p o l y c h r o m a t i c   e r y t h r o - c y t e s   i n   m o u s e   b o n e   m a r r o w   a n d   p e r i p h e r a l   b l o o d . M u t a g e n e s i s   5 ,   3 1 3 - 3 2 1 . U e m u r a ,   T . ,   O d a ,   K . ,   O m a e ,   K . ,   T a k e b a y a s h i ,   T . , N o m i y a m a ,   T . ,   I s h i z u k u ,   C . ,   H o s o d a ,   K . ,   S a k u r a i ,   H . , Y a m a z a k i ,   K . ,   a n d   K a b e ,   I .   ( 1 9 9 7 ) .     E f f e c t s   o f   i n t r a - t r a c h e a l l y   a d m i n i s t e r e d   i n d i u m   p h o s p h i d e   o n   m a l e F i s c h e r   3 4 4   r a t s .     J .   O c c u p .   H e a l t h   3 9 ,   2 0 5 - 2 1 0 . W i l l i a m s ,   D . A .   ( 1 9 7 1 ) .     A   t e s t   f o r   d i f f e r e n c e s   b e t w e e n t r e a t m e n t   m e a n s   w h e n   s e v e r a l   d o s e   l e v e l s   a r e   c o m p a r e d w i t h   a   z e r o   d o s e   c o n t r o l .     B i o m e t r i c s   2 7 ,   1 0 3 - 1 1 7 . W i l l i a m s ,   D . A .   ( 1 9 7 2 ) .     T h e   c o m p a r i s o n   o f   s e v e r a l d o s e   l e v e l s   w i t h   a   z e r o   d o s e   c o n t r o l .     B i o m e t r i c s   2 8 , 5 1 9 - 5 3 1 . W i t t ,   K . L . ,   K n a p t o n ,   A . ,   W e h r ,   C . M . ,   H o o k ,   G . J . , M i r s a l i s ,   J . ,   S h e l b y ,   M . D . ,   a n d   M a c G r e g o r ,   J . T .   ( 2 0 0 0 ) . M i c r o n u c l e a t e d   e r y t h r o c y t e   f r e q u e n c y   i n   p e r i p h e r a l b l o o d   o f   B 6 C 3 F 1   m i c e   f r o m   s h o r t - t e r m ,   p r e c h r o n i c ,   a n d c h r o n i c   s t u d i e s   o f   t h e   N T P   C a r c i n o g e n e s i s   B i o a s s a y P r o g r a m .     E n v i r o n .   M o l .   M u t a g e n .     3 6 ,   1 6 3 - 1 9 4 . Z h e n g ,   W . ,   W i n t e r ,   S . M . ,   K a t t n i g ,   M . J . ,   C a r t e r ,   D . E . , a n d   S i p e s ,   I . G .   ( 1 9 9 4 ) .     T i s s u e   d i s t r i b u t i o n   a n d   e l i m i n a - t i o n   o f   i n d i u m   i n   m a l e   F i s c h e r   3 4 4   r a t s   f o l l o w i n g   o r a l a n d   i n t r a t r a c h e a l   a d m i n i s t r a t i o n   o f   i n d i u m   p h o s p h i d e . J .   T o x i c o l .   E n v i r o n .   H e a l t h   4 3 ,   4 8 3 - 4 9 4 . 1 0 2 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 0 3 A P P E N D I X   A S U M M A R Y   O F   L E S I O N S   I N   M A L E   R A T S I N   T H E   2 - Y E A R   I N H A L A T I O N   S T U D Y O F   I N D I U M   P H O S P H I D E T A B L E   A 1 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N e o p l a s m s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 0 5 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1 0 T A B L E   A 3 S t a t i s t i c a l   A n a l y s i s   o f   P r i m a r y   N e o p l a s m s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 3 4 T A B L E   A 4 a H i s t o r i c a l   I n c i d e n c e   o f   L u n g   N e o p l a s m s   i n   C o n t r o l   M a l e   F 3 4 4 / N   R a t s . . . . . . . . . . . . . . . . 1 3 9 T A B L E   A 4 b H i s t o r i c a l   I n c i d e n c e   o f   A d r e n a l   M e d u l l a   P h e o c h r o m o c y t o m a i n   C o n t r o l   M a l e   F 3 4 4 / N   R a t s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 4 0 T A B L E   A 4 c H i s t o r i c a l   I n c i d e n c e   o f   S k i n   N e o p l a s m s   i n   C o n t r o l   M a l e   F 3 4 4 / N   R a t s . . . . . . . . . . . . . . . . . 1 4 1 T A B L E   A 4 d H i s t o r i c a l   I n c i d e n c e   o f   M o n o n u c l e a r   C e l l   L e u k e m i a   i n   C o n t r o l   M a l e   F 3 4 4 / N   R a t s . . . . . . 1 4 2 T A B L E   A 5 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N o n n e o p l a s t i c   L e s i o n s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 4 3 1 0 4 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 0 5 T A B L E   A 1 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N e o p l a s m s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e a C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) D i s p o s i t i o n   S u m m a r y A n i m a l s   i n i t i a l l y   i n   s t u d y 6 0 6 0 6 0 6 0 3 - M o n t h   i n t e r i m   e v a l u a t i o n 1 0 1 0 1 0 1 0 E a r l y   d e a t h s M o r i b u n d 2 0 1 8 1 6 1 5 N a t u r a l   d e a t h s 3 3 5 9 S u r v i v o r s T e r m i n a l   s a c r i f i c e 2 7 2 9 2 9 2 6 A n i m a l s   e x a m i n e d   m i c r o s c o p i c a l l y 6 0 6 0 6 0 6 0 S y s t e m s   E x a m i n e d   a t   3   M o n t h s   w i t h   N o   N e o p l a s m s   O b s e r v e d   A l i m e n t a r y   S y s t e m C a r d i o v a s c u l a r   S y s t e m E n d o c r i n e   S y s t e m G e n e r a l   B o d y   S y s t e m G e n i t a l   S y s t e m H e m a t o p o i e t i c   S y s t e m I n t e g u m e n t a r y   S y s t e m M u s c u l o s k e l e t a l   S y s t e m N e r v o u s   S y s t e m R e s p i r a t o r y   S y s t e m S p e c i a l   S e n s e s   S y s t e m U r i n a r y   S y s t e m 2 - Y e a r   S t u d y A l i m e n t a r y   S y s t e m E s o p h a g u s ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) S q u a m o u s   c e l l   p a p i l l o m a                       1 ( 2 % )                                         I n t e s t i n e   l a r g e ,   c o l o n ( 5 0 ) ( 5 0 ) ( 4 7 ) ( 4 8 ) P o l y p   a d e n o m a t o u s                                         1 ( 2 % )                       I n t e s t i n e   l a r g e ,   c e c u m ( 4 8 ) ( 5 0 ) ( 4 6 ) ( 4 6 ) I n t e s t i n e   s m a l l ,   d u o d e n u m ( 4 9 ) ( 5 0 ) ( 4 7 ) ( 4 8 ) I n t e s t i n e   s m a l l ,   j e j u n u m ( 4 8 ) ( 4 8 ) ( 4 6 ) ( 4 3 ) C a r c i n o m a                       1 ( 2 % )                                         I n t e s t i n e   s m a l l ,   i l e u m ( 4 7 ) ( 4 9 ) ( 4 6 ) ( 4 4 ) L i v e r ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) C h o l a n g i o c a r c i n o m a                       1 ( 2 % )                           1 ( 2 % )     C h o l a n g i o m a                       1 ( 2 % )                                         H e p a t o c e l l u l a r   a d e n o m a                                         1 ( 2 % )                       H i s t i o c y t i c   s a r c o m a                       1 ( 2 % )                                         O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e     1 ( 2 % )                                                           M e s e n t e r y   ( 6 )   ( 6 )   ( 6 )   ( 8 ) S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g                                                           1 ( 1 3 % )   O r a l   m u c o s a   ( 1 )           ( 3 )   ( 2 ) G i n g i v a l ,   s q u a m o u s   c e l l   p a p i l l o m a                                         2 ( 6 7 % )                     P h a r y n g e a l ,   s q u a m o u s   c e l l   p a p i l l o m a     1 ( 1 0 0 % )                       1 ( 3 3 % )       1 ( 5 0 % )   P a n c r e a s ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) A d e n o m a     1 ( 2 % )                                                           H i s t i o c y t i c   s a r c o m a                       1 ( 2 % )                                         S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g                                                           1 ( 2 % )     1 0 6 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 1 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N e o p l a s m s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) 2 - Y e a r   S t u d y   ( c o n t i n u e d ) A l i m e n t a r y   S y s t e m   ( c o n t i n u e d ) S a l i v a r y   g l a n d s ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) S t o m a c h ,   f o r e s t o m a c h ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) L e i o m y o s a r c o m a                                         1 ( 2 % )                       S t o m a c h ,   g l a n d u l a r ( 5 0 ) ( 5 0 ) ( 4 8 ) ( 4 9 ) C a r d i o v a s c u l a r   S y s t e m H e a r t ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m e t a s t a t i c ,                                                                                l u n g                       1 ( 2 % )                           1 ( 2 % )     O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e     1 ( 2 % )                                                           S c h w a n n o m a   b e n i g n     1 ( 2 % )                                             1 ( 2 % )     S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g                                                           1 ( 2 % )     P e r i c a r d i u m ,   a l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,                                                                                m e t a s t a t i c ,   l u n g                                         1 ( 2 % )                       E n d o c r i n e   S y s t e m A d r e n a l   c o r t e x ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) A d e n o m a                       1 ( 2 % )                                         C a r c i n o m a                       1 ( 2 % )                                         S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g                                                           1 ( 2 % )     A d r e n a l   m e d u l l a ( 5 0 ) ( 5 0 ) ( 4 9 ) ( 5 0 ) P h e o c h r o m o c y t o m a   m a l i g n a n t                       3 ( 6 % )         3 ( 6 % )         1 ( 2 % )     P h e o c h r o m o c y t o m a   c o m p l e x                       1 ( 2 % )                                         P h e o c h r o m o c y t o m a   b e n i g n   1 0 ( 2 0 % )     1 6 ( 3 2 % )     1 2 ( 2 4 % )     1 8 ( 3 6 % )   S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g                                                           1 ( 2 % )     B i l a t e r a l ,   p h e o c h r o m o c y t o m a   b e n i g n                       6 ( 1 2 % )       4 ( 8 % )         5 ( 1 0 % )   I s l e t s ,   p a n c r e a t i c ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) A d e n o m a     1 ( 2 % )         2 ( 4 % )         2 ( 4 % )         3 ( 6 % )     C a r c i n o m a     2 ( 4 % )                           4 ( 8 % )         3 ( 6 % )     S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g                                                           1 ( 2 % )     P a r a t h y r o i d   g l a n d ( 4 4 ) ( 4 4 ) ( 4 5 ) ( 4 5 ) A d e n o m a     1 ( 2 % )                                                           P i t u i t a r y   g l a n d ( 4 9 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) P a r s   d i s t a l i s ,   a d e n o m a   3 6 ( 7 3 % )     3 3 ( 6 6 % )     3 1 ( 6 2 % )     3 0 ( 6 0 % )   P a r s   d i s t a l i s ,   c a r c i n o m a     1 ( 2 % )         1 ( 2 % )                                         P a r s   i n t e r m e d i a ,   a d e n o m a                       1 ( 2 % )                                         T h y r o i d   g l a n d ( 4 9 ) ( 4 9 ) ( 4 8 ) ( 4 8 ) B i l a t e r a l ,   C - c e l l ,   a d e n o m a                       1 ( 2 % )                                         C - c e l l ,   a d e n o m a     5 ( 1 0 % )       7 ( 1 4 % )       4 ( 8 % )         9 ( 1 9 % )   C - c e l l ,   c a r c i n o m a     1 ( 2 % )         4 ( 8 % )         3 ( 6 % )         1 ( 2 % )     F o l l i c u l a r   c e l l ,   a d e n o m a                       1 ( 2 % )                                         G e n e r a l   B o d y   S y s t e m P e r i t o n e u m   ( 1 )   ( 1 )                 H i s t i o c y t i c   s a r c o m a                       1 ( 1 0 0 % )                                     T i s s u e   N O S                           ( 1 ) C h e m o d e c t o m a   m a l i g n a n t                                                           1 ( 1 0 0 % ) I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 0 7 T A B L E   A 1 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N e o p l a s m s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) 2 - Y e a r   S t u d y   ( c o n t i n u e d ) G e n i t a l   S y s t e m E p i d i d y m i s ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) H i s t i o c y t i c   s a r c o m a                       1 ( 2 % )                                         P r e p u t i a l   g l a n d ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) A d e n o m a     1 ( 2 % )         2 ( 4 % )                                         C a r c i n o m a     2 ( 4 % )                           1 ( 2 % )                       P r o s t a t e ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) A d e n o m a     1 ( 2 % )         2 ( 4 % )         1 ( 2 % )         2 ( 4 % )     A d e n o m a ,   m u l t i p l e                                         1 ( 2 % )                       S e m i n a l   v e s i c l e ( 5 0 ) ( 4 9 ) ( 4 8 ) ( 4 9 ) A d e n o m a                       1 ( 2 % )                                         H i s t i o c y t i c   s a r c o m a                       1 ( 2 % )                                         T e s t e s ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) B i l a t e r a l ,   i n t e r s t i t i a l   c e l l ,   a d e n o m a   2 7 ( 5 4 % )     2 5 ( 5 0 % )     2 6 ( 5 2 % )     1 7 ( 3 4 % )   I n t e r s t i t i a l   c e l l ,   a d e n o m a   1 3 ( 2 6 % )     1 0 ( 2 0 % )     1 5 ( 3 0 % )     1 6 ( 3 2 % )   H e m a t o p o i e t i c   S y s t e m B o n e   m a r r o w ( 5 0 ) ( 5 0 ) ( 4 9 ) ( 5 0 ) L y m p h   n o d e   ( 2 )   ( 4 )           ( 2 ) R e n a l ,   s q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,                                                                                l u n g                                                           1 ( 5 0 % )   L y m p h   n o d e ,   b r o n c h i a l ( 2 6 ) ( 2 7 ) ( 4 1 ) ( 4 4 ) H i s t i o c y t i c   s a r c o m a                       1 ( 4 % )                                         S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g                                                           1 ( 2 % )     L y m p h   n o d e ,   m a n d i b u l a r ( 4 4 ) ( 4 2 ) ( 4 7 ) ( 4 7 ) S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g                                                           1 ( 2 % )     L y m p h   n o d e ,   m e s e n t e r i c ( 5 0 ) ( 5 0 ) ( 4 9 ) ( 5 0 ) L y m p h   n o d e ,   m e d i a s t i n a l ( 2 5 ) ( 1 9 ) ( 4 5 ) ( 4 0 ) S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g                                                           2 ( 5 % )     S p l e e n ( 5 0 ) ( 5 0 ) ( 4 9 ) ( 4 8 ) T h y m u s ( 4 7 ) ( 4 7 ) ( 4 6 ) ( 4 5 ) I n t e g u m e n t a r y   S y s t e m M a m m a r y   g l a n d ( 2 4 ) ( 3 3 ) ( 3 1 ) ( 2 4 ) C a r c i n o m a                                         1 ( 3 % )         1 ( 4 % )     F i b r o a d e n o m a     2 ( 8 % )         1 ( 3 % )                           1 ( 4 % )     S k i n ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 4 9 ) H i s t i o c y t i c   s a r c o m a                       1 ( 2 % )                                         K e r a t o a c a n t h o m a     2 ( 4 % )         3 ( 6 % )         5 ( 1 0 % )       2 ( 4 % )     K e r a t o a c a n t h o m a ,   m u l t i p l e                       1 ( 2 % )                                         S q u a m o u s   c e l l   p a p i l l o m a                                                           1 ( 2 % )     T r i c h o e p i t h e l i o m a                                         1 ( 2 % )                       S e b a c e o u s   g l a n d ,   a d e n o m a     1 ( 2 % )         1 ( 2 % )                                         S u b c u t a n e o u s   t i s s u e ,   f i b r o m a     1 ( 2 % )         4 ( 8 % )         7 ( 1 4 % )       3 ( 6 % )     S u b c u t a n e o u s   t i s s u e ,   f i b r o s a r c o m a     1 ( 2 % )         2 ( 4 % )         1 ( 2 % )         1 ( 2 % )     S u b c u t a n e o u s   t i s s u e ,   h e m a n g i o s a r c o m a     1 ( 2 % )                                                           S u b c u t a n e o u s   t i s s u e ,   l i p o m a     1 ( 2 % )         1 ( 2 % )         2 ( 4 % )         1 ( 2 % )     S u b c u t a n e o u s   t i s s u e ,   l i p o s a r c o m a                                         1 ( 2 % )                       1 0 8 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 1 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N e o p l a s m s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) 2 - Y e a r   S t u d y   ( c o n t i n u e d ) M u s c u l o s k e l e t a l   S y s t e m B o n e ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) F i b r o s a r c o m a ,   m e t a s t a t i c ,   s k i n                       1 ( 2 % )                                         O s t e o m a                                         1 ( 2 % )                       O s t e o s a r c o m a     3 ( 6 % )                           1 ( 2 % )         1 ( 2 % )     S k e l e t a l   m u s c l e                   ( 1 )         R h a b d o m y o s a r c o m a                                         1 ( 1 0 0 % )                   N e r v o u s   S y s t e m B r a i n ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) G l i o m a   b e n i g n                       1 ( 2 % )                                         H i s t i o c y t i c   s a r c o m a                       1 ( 2 % )                                         R e s p i r a t o r y   S y s t e m L a r y n x ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) C a r c i n o m a ,   m e t a s t a t i c ,   t h y r o i d   g l a n d                       1 ( 2 % )                                         L u n g ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) A l v e o l a r / b r o n c h i o l a r   a d e n o m a     5 ( 1 0 % )       8 ( 1 6 % )     1 9 ( 3 8 % )     1 8 ( 3 6 % )   A l v e o l a r / b r o n c h i o l a r   a d e n o m a ,   m u l t i p l e     1 ( 2 % )         5 ( 1 0 % )       8 ( 1 6 % )     1 2 ( 2 4 % )   A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a     1 ( 2 % )         8 ( 1 6 % )       7 ( 1 4 % )     1 1 ( 2 2 % )   A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m u l t i p l e                       2 ( 4 % )         1 ( 2 % )         5 ( 1 0 % )   C a r c i n o m a ,   m e t a s t a t i c ,   p i t u i t a r y   g l a n d     1 ( 2 % )         1 ( 2 % )                                         C a r c i n o m a ,   m e t a s t a t i c ,   t h y r o i d   g l a n d                       1 ( 2 % )                                         H i s t i o c y t i c   s a r c o m a                       1 ( 2 % )                                         O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e     2 ( 4 % )                                                           P h e o c h r o m o c y t o m a   m a l i g n a n t ,   m e t a s t a t i c ,                                                                                a d r e n a l   m e d u l l a                       1 ( 2 % )                                         S q u a m o u s   c e l l   c a r c i n o m a                                                           4 ( 8 % )     M e d i a s t i n u m ,   o s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e     1 ( 2 % )                                                           N o s e ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) C h o n d r o m a     1 ( 2 % )                                                           E s t h e s i o n e u r o b l a s t o m a                                         1 ( 2 % )                       O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e                                         1 ( 2 % )                       S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g                                                           1 ( 2 % )     P l e u r a           ( 2 )           ( 2 ) A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m e t a s t a t i c ,                                                                                l u n g                       1 ( 5 0 % )                         1 ( 5 0 % )   H i s t i o c y t i c   s a r c o m a                       1 ( 5 0 % )                                       S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g                                                           1 ( 5 0 % )   S p e c i a l   S e n s e s   S y s t e m Z y m b a l ’ s   g l a n d           ( 1 )   ( 1 )   ( 1 ) A d e n o m a                                                           1 ( 1 0 0 % ) C a r c i n o m a                       1 ( 1 0 0 % )     1 ( 1 0 0 % )                   I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 0 9 T A B L E   A 1 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N e o p l a s m s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) 2 - Y e a r   S t u d y   ( c o n t i n u e d ) U r i n a r y   S y s t e m K i d n e y ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) H i s t i o c y t i c   s a r c o m a                       1 ( 2 % )                                         L i p o s a r c o m a                                         1 ( 2 % )                       O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e     1 ( 2 % )                                                           S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g                                                           2 ( 4 % )     U r i n a r y   b l a d d e r ( 5 0 ) ( 5 0 ) ( 4 9 ) ( 5 0 ) T r a n s i t i o n a l   e p i t h e l i u m ,   p a p i l l o m a                                         1 ( 2 % )         1 ( 2 % )     S y s t e m i c   L e s i o n s M u l t i p l e   o r g a n s b ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) H i s t i o c y t i c   s a r c o m a                       3 ( 6 % )                                         L e u k e m i a   m o n o n u c l e a r   1 6 ( 3 2 % )     2 3 ( 4 6 % )     2 9 ( 5 8 % )     2 5 ( 5 0 % )   M e s o t h e l i o m a   m a l i g n a n t     2 ( 4 % )                           1 ( 2 % )                       N e o p l a s m   S u m m a r y T o t a l   a n i m a l s   w i t h   p r i m a r y   n e o p l a s m s c 2 - Y e a r   s t u d y 4 9 5 0 5 0 5 0 T o t a l   p r i m a r y   n e o p l a s m s 2 - Y e a r   s t u d y   1 4 2 1 8 6 2 0 3 1 9 7 T o t a l   a n i m a l s   w i t h   b e n i g n   n e o p l a s m s 2 - Y e a r   s t u d y   4 7 4 8 4 8 4 8 T o t a l   b e n i g n   n e o p l a s m s 2 - Y e a r   s t u d y   1 1 2 1 3 5 1 4 5 1 4 2 T o t a l   a n i m a l s   w i t h   m a l i g n a n t   n e o p l a s m s 2 - Y e a r   s t u d y   2 6 3 7 4 2 3 7 T o t a l   m a l i g n a n t   n e o p l a s m s 2 - Y e a r   s t u d y   3 0 5 1 5 8 5 5 T o t a l   a n i m a l s   w i t h   m e t a s t a t i c   n e o p l a s m s 2 - Y e a r   s t u d y   3 5 2 4 T o t a l   m e t a s t a t i c   n e o p l a s m s 2 - Y e a r   s t u d y   7 7 2 1 7 a N u m b e r   o f   a n i m a l s   e x a m i n e d   m i c r o s c o p i c a l l y   a t   t h e   s i t e   a n d   t h e   n u m b e r   o f   a n i m a l s   w i t h   n e o p l a s m b N u m b e r   o f   a n i m a l s   w i t h   a n y   t i s s u e   e x a m i n e d   m i c r o s c o p i c a l l y c P r i m a r y   n e o p l a s m s :     a l l   n e o p l a s m s   e x c e p t   m e t a s t a t i c   n e o p l a s m s 1 1 0 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     C h a m b e r   C o n t r o l   1 4 4 4 5 5 5 5 5 6 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 0 7 9 2 3 5 5 6 0 1 2 3 4 4 5 7 7 9 0 0 0 1 3 3 5 8 6 5 5 7 1 2 9 0 7 4 9 7 9 6 2 2 7 0 3 9 4 3 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C a r c a s s   I D   N u m b e r 4 4 1 3 3 1 3 2 2 1 1 0 3 4 0 3 2 4 4 2 4 1 0 0 0 4 3 9 6 9 4 3 9 6 7 0 4 2 8 5 1 0 5 9 8 2 6 8 2 3 A l i m e n t a r y   S y s t e m E s o p h a g u s + + + + + + + + + + + + + + + + + + + + + + + + + I n t e s t i n e   l a r g e ,   c o l o n + + + + + + + + + + + + + + + + + + + + + + + + + I n t e s t i n e   l a r g e ,   r e c t u m + + + + + + + + + + + + + + + I + + + + + I + + + I n t e s t i n e   l a r g e ,   c e c u m + + + + + + + + + + + + + A + + + + + + + A + + + I n t e s t i n e   s m a l l ,   d u o d e n u m + + + + + + + + + + + + + A + + + + + + + + + + + I n t e s t i n e   s m a l l ,   j e j u n u m + + + + + + + + + + + + + A + + + + + + + A + + + I n t e s t i n e   s m a l l ,   i l e u m + + + + + + + + + + + + + A A + + + + + + A + + + L i v e r + + + + + + + + + + + + + + + + + + + + + + + + + O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e X M e s e n t e r y + + O r a l   m u c o s a P h a r y n g e a l ,   s q u a m o u s   c e l l   p a p i l l o m a P a n c r e a s + + + + + + + + + + + + + + + + + + + + + + + + + A d e n o m a S a l i v a r y   g l a n d s + + + + + + + + + + + + + + + + + + + + + + + + + S t o m a c h ,   f o r e s t o m a c h + + + + + + + + + + + + + + + + + + + + + + + + + S t o m a c h ,   g l a n d u l a r + + + + + + + + + + + + + + + + + + + + + + + + + T o n g u e T o o t h + + C a r d i o v a s c u l a r   S y s t e m   B l o o d   v e s s e l + H e a r t + + + + + + + + + + + + + + + + + + + + + + + + + O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e X S c h w a n n o m a   b e n i g n X E n d o c r i n e   S y s t e m     A d r e n a l   c o r t e x + + + + + + + + + + + + + + + + + + + + + + + + + A d r e n a l   m e d u l l a + + + + + + + + + + + + + + + + + + + + + + + + + P h e o c h r o m o c y t o m a   b e n i g n X X X X I s l e t s ,   p a n c r e a t i c + + + + + + + + + + + + + + + + + + + + + + + + + A d e n o m a C a r c i n o m a X X P a r a t h y r o i d   g l a n d M + + + + + + + + + M + + + + + + + + + M + + + + A d e n o m a P i t u i t a r y   g l a n d + + + + + + M + + + + + + + + + + + + + + + + + + P a r s   d i s t a l i s ,   a d e n o m a X X X X X X X X X X X X X X X X X P a r s   d i s t a l i s ,   c a r c i n o m a T h y r o i d   g l a n d + + + + + + + + + + + + + A + + + + + + + + + + + C - c e l l ,   a d e n o m a X C - c e l l ,   c a r c i n o m a X G e n e r a l   B o d y   S y s t e m   P e r i t o n e u m + + :     T i s s u e   e x a m i n e d   m i c r o s c o p i c a l l y M :     M i s s i n g   t i s s u e X :     L e s i o n   p r e s e n t A :     A u t o l y s i s   p r e c l u d e s   e x a m i n a t i o n I :     I n s u f f i c i e n t   t i s s u e B l a n k :     N o t   e x a m i n e d I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 1 1 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     C h a m b e r   C o n t r o l   7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 5 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 T o t a l C a r c a s s   I D   N u m b e r 0 0 1 2 3 3 4 4 0 0 1 1 1 1 2 2 2 2 3 3 4 4 5 2 3 T i s s u e s / 7 9 2 5 4 8 0 6 1 6 1 3 5 8 1 2 4 7 0 7 1 7 0 3 5 T u m o r s A l i m e n t a r y   S y s t e m   E s o p h a g u s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 I n t e s t i n e   l a r g e ,   c o l o n + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 I n t e s t i n e   l a r g e ,   r e c t u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 8 I n t e s t i n e   l a r g e ,   c e c u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 8 I n t e s t i n e   s m a l l ,   d u o d e n u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 I n t e s t i n e   s m a l l ,   j e j u n u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 8 I n t e s t i n e   s m a l l ,   i l e u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 7 L i v e r + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e 1 M e s e n t e r y + + + +   6 O r a l   m u c o s a +   1 P h a r y n g e a l ,   s q u a m o u s   c e l l   p a p i l l o m a X   1 P a n c r e a s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d e n o m a X   1 S a l i v a r y   g l a n d s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S t o m a c h ,   f o r e s t o m a c h + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S t o m a c h ,   g l a n d u l a r + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 T o n g u e + +   2 T o o t h   2 C a r d i o v a s c u l a r   S y s t e m   B l o o d   v e s s e l   1 H e a r t + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e   1 S c h w a n n o m a   b e n i g n   1 E n d o c r i n e   S y s t e m A d r e n a l   c o r t e x + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d r e n a l   m e d u l l a + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 P h e o c h r o m o c y t o m a   b e n i g n X X X X X X 1 0 I s l e t s ,   p a n c r e a t i c + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d e n o m a X   1 C a r c i n o m a   2 P a r a t h y r o i d   g l a n d M M + + + + + + + + + + + + + + + + M + + + + + + 4 4 A d e n o m a X 1 P i t u i t a r y   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 P a r s   d i s t a l i s ,   a d e n o m a X X X X X X X X X X X X X X X X X X X 3 6 P a r s   d i s t a l i s ,   c a r c i n o m a X 1 T h y r o i d   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 C - c e l l ,   a d e n o m a X X X X 5 C - c e l l ,   c a r c i n o m a 1 G e n e r a l   B o d y   S y s t e m   P e r i t o n e u m 1 1 1 2 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e : C h a m b e r   C o n t r o l   1 4 4 4 5 5 5 5 5 6 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 0 7 9 2 3 5 5 6 0 1 2 3 4 4 5 7 7 9 0 0 0 1 3 3 5 8 6 5 5 7 1 2 9 0 7 4 9 7 9 6 2 2 7 0 3 9 4 3 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C a r c a s s   I D   N u m b e r 4 4 1 3 3 1 3 2 2 1 1 0 3 4 0 3 2 4 4 2 4 1 0 0 0 4 3 9 6 9 4 3 9 6 7 0 4 2 8 5 1 0 5 9 8 2 6 8 2 3 G e n i t a l   S y s t e m E p i d i d y m i s + + + + + + + + + + + + + + + + + + + + + + + + + P r e p u t i a l   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + A d e n o m a C a r c i n o m a X X P r o s t a t e + + + + + + + + + + + + + + + + + + + + + + + + + A d e n o m a S e m i n a l   v e s i c l e + + + + + + + + + + + + + + + + + + + + + + + + + T e s t e s + + + + + + + + + + + + + + + + + + + + + + + + + B i l a t e r a l ,   i n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X X X X X I n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X X X H e m a t o p o i e t i c   S y s t e m B o n e   m a r r o w + + + + + + + + + + + + + + + + + + + + + + + + + L y m p h   n o d e + L y m p h   n o d e ,   b r o n c h i a l M + M + + + + + + + M M + + + M + M M M M + + M M L y m p h   n o d e ,   m a n d i b u l a r + + + + + + + + + + + + + + + + + + + + + + + M M L y m p h   n o d e ,   m e s e n t e r i c + + + + + + + + + + + + + + + + + + + + + + + + + L y m p h   n o d e ,   m e d i a s t i n a l + + M M + + + + + + + M + + + + + M M M M + M M M S p l e e n + + + + + + + + + + + + + + + + + + + + + + + + + T h y m u s + + + + + + + + + + + + + + + + + + + + + + + + + I n t e g u m e n t a r y   S y s t e m M a m m a r y   g l a n d M M M M + M M + M + + + M M M + + + + M + M M M M F i b r o a d e n o m a S k i n + + + + + + + + + + + + + + + + + + + + + + + + + K e r a t o a c a n t h o m a S e b a c e o u s   g l a n d ,   a d e n o m a X S u b c u t a n e o u s   t i s s u e ,   f i b r o m a X S u b c u t a n e o u s   t i s s u e ,   f i b r o s a r c o m a S u b c u t a n e o u s   t i s s u e ,   h e m a n g i o s a r c o m a X S u b c u t a n e o u s   t i s s u e ,   l i p o m a M u s c u l o s k e l e t a l   S y s t e m B o n e + + + + + + + + + + + + + + + + + + + + + + + + + O s t e o s a r c o m a X X X N e r v o u s   S y s t e m B r a i n + + + + + + + + + + + + + + + + + + + + + + + + + S p i n a l   c o r d + R e s p i r a t o r y   S y s t e m L a r y n x + + + + + + + + + + + + + + + + + + + + + + + + + L u n g + + + + + + + + + + + + + + + + + + + + + + + + + A l v e o l a r / b r o n c h i o l a r   a d e n o m a X X A l v e o l a r / b r o n c h i o l a r   a d e n o m a ,   m u l t i p l e A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a X C a r c i n o m a ,   m e t a s t a t i c ,   p i t u i t a r y   g l a n d O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e X X M e d i a s t i n u m ,   o s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e X N o s e + + + + + + + + + + + + + + + + + + + + + + + + + C h o n d r o m a X T r a c h e a + + + + + + + + + + + + + + + + + + + + + + + + + I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 1 3 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e : C h a m b e r   C o n t r o l   7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 5 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 T o t a l C a r c a s s   I D   N u m b e r 0 0 1 2 3 3 4 4 0 0 1 1 1 1 2 2 2 2 3 3 4 4 5 2 3 T i s s u e s / 7 9 2 5 4 8 0 6 1 6 1 3 5 8 1 2 4 7 0 7 1 7 0 3 5 T u m o r s G e n i t a l   S y s t e m     E p i d i d y m i s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 P r e p u t i a l   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d e n o m a X   1 C a r c i n o m a   2 P r o s t a t e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d e n o m a X   1 S e m i n a l   v e s i c l e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 T e s t e s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 B i l a t e r a l ,   i n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X X X X X X X X X X X X 2 7 I n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X 1 3 H e m a t o p o i e t i c   S y s t e m B o n e   m a r r o w + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L y m p h   n o d e +   2 L y m p h   n o d e ,   b r o n c h i a l M M + M M + + M + + + + M M M + M M M + + + M M + 2 6 L y m p h   n o d e ,   m a n d i b u l a r M + + + + + + + + M + + + + + + + + + M M + + + + 4 4 L y m p h   n o d e ,   m e s e n t e r i c + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L y m p h   n o d e ,   m e d i a s t i n a l M + + + + M + M + + + + M M M + M M M M M M M M M 2 5 S p l e e n + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 T h y m u s + + + + M + + + + + + + + + + + + M + M + + + + + 4 7 I n t e g u m e n t a r y   S y s t e m M a m m a r y   g l a n d M + + + M M M + M M + + + M M + + M + + + M + + M 2 4 F i b r o a d e n o m a X X   2 S k i n + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 K e r a t o a c a n t h o m a X X   2 S e b a c e o u s   g l a n d ,   a d e n o m a   1 S u b c u t a n e o u s   t i s s u e ,   f i b r o m a   1 S u b c u t a n e o u s   t i s s u e ,   f i b r o s a r c o m a X   1 S u b c u t a n e o u s   t i s s u e ,   h e m a n g i o s a r c o m a   1 S u b c u t a n e o u s   t i s s u e ,   l i p o m a X   1 M u s c u l o s k e l e t a l   S y s t e m B o n e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 O s t e o s a r c o m a   3 N e r v o u s   S y s t e m B r a i n + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S p i n a l   c o r d   1 R e s p i r a t o r y   S y s t e m L a r y n x + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L u n g + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A l v e o l a r / b r o n c h i o l a r   a d e n o m a X X X   5 A l v e o l a r / b r o n c h i o l a r   a d e n o m a ,   m u l t i p l e X   1 A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a   1 C a r c i n o m a ,   m e t a s t a t i c ,   p i t u i t a r y   g l a n d X   1 O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e   2 M e d i a s t i n u m ,   o s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e   1 N o s e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 C h o n d r o m a   1 T r a c h e a + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 1 1 4 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e : C h a m b e r   C o n t r o l   1 4 4 4 5 5 5 5 5 6 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 0 7 9 2 3 5 5 6 0 1 2 3 4 4 5 7 7 9 0 0 0 1 3 3 5 8 6 5 5 7 1 2 9 0 7 4 9 7 9 6 2 2 7 0 3 9 4 3 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C a r c a s s   I D   N u m b e r 4 4 1 3 3 1 3 2 2 1 1 0 3 4 0 3 2 4 4 2 4 1 0 0 0 4 3 9 6 9 4 3 9 6 7 0 4 2 8 5 1 0 5 9 8 2 6 8 2 3 S p e c i a l   S e n s e s   S y s t e m   E a r E y e + U r i n a r y   S y s t e m K i d n e y + + + + + + + + + + + + + + + + + + + + + + + + + O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e X U r i n a r y   b l a d d e r + + + + + + + + + + + + + + + + + + + + + + + + + S y s t e m i c   L e s i o n s M u l t i p l e   o r g a n s + + + + + + + + + + + + + + + + + + + + + + + + + L e u k e m i a   m o n o n u c l e a r X X X X X X X M e s o t h e l i o m a   m a l i g n a n t X I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 1 5 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e : C h a m b e r   C o n t r o l   7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 5 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 T o t a l C a r c a s s   I D   N u m b e r 0 0 1 2 3 3 4 4 0 0 1 1 1 1 2 2 2 2 3 3 4 4 5 2 3 T i s s u e s / 7 9 2 5 4 8 0 6 1 6 1 3 5 8 1 2 4 7 0 7 1 7 0 3 5   T u m o r s S p e c i a l   S e n s e s   S y s t e m   E a r +   1 E y e   1 U r i n a r y   S y s t e m                 K i d n e y + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e   1 U r i n a r y   b l a d d e r + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S y s t e m i c   L e s i o n s             M u l t i p l e   o r g a n s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L e u k e m i a   m o n o n u c l e a r X X X X X X X X X 1 6 M e s o t h e l i o m a   m a l i g n a n t X   2 1 1 6 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 0 3   m g / m 3 2 5 5 5 5 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 8 2 6 7 8 2 3 4 5 8 8 8 8 9 0 0 0 0 1 1 2 3 3 3 3 5 6 9 6 6 8 5 3 8 3 4 5 6 5 0 1 2 7 4 4 3 3 3 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 C a r c a s s   I D   N u m b e r 3 5 3 4 4 0 2 3 0 2 1 3 3 3 2 3 2 3 0 1 0 0 0 1 1 8 0 4 1 3 5 5 1 6 7 2 6 3 7 4 2 9 5 9 6 2 1 4 3 4 A l i m e n t a r y   S y s t e m           E s o p h a g u s + + + + + + + + + + + + + + + + + + + + + + + + + S q u a m o u s   c e l l   p a p i l l o m a X I n t e s t i n e   l a r g e ,   c o l o n + + + + + + + + + + + + + + + + + + + + + + + + + I n t e s t i n e   l a r g e ,   r e c t u m + + + + + + + + + + + + + + + + + + + + + + + + + I n t e s t i n e   l a r g e ,   c e c u m + + + + + + + + + + + + + + + + + + + + + + + + + I n t e s t i n e   s m a l l ,   d u o d e n u m + + + + + + + + + + + + + + + + + + + + + + + + + I n t e s t i n e   s m a l l ,   j e j u n u m + + + + + + + + + + + + + + + A + A + + + + + + + C a r c i n o m a I n t e s t i n e   s m a l l ,   i l e u m + + + + + + + + + + + + + + + A + + + + + + + + + L i v e r + + + + + + + + + + + + + + + + + + + + + + + + + C h o l a n g i o c a r c i n o m a C h o l a n g i o m a X H i s t i o c y t i c   s a r c o m a X M e s e n t e r y + + + + P a n c r e a s + + + + + + + + + + + + + + + + + + + + + + + + + H i s t i o c y t i c   s a r c o m a X S a l i v a r y   g l a n d s + + + + + + + + + + + + + + + + + + + + + + + + + S t o m a c h ,   f o r e s t o m a c h + + + + + + + + + + + + + + + + + + + + + + + + + S t o m a c h ,   g l a n d u l a r + + + + + + + + + + + + + + + + + + + + + + + + + C a r d i o v a s c u l a r   S y s t e m   H e a r t + + + + + + + + + + + + + + + + + + + + + + + + + A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X E n d o c r i n e   S y s t e m             A d r e n a l   c o r t e x + + + + + + + + + + + + + + + + + + + + + + + + + A d e n o m a X C a r c i n o m a X A d r e n a l   m e d u l l a + + + + + + + + + + + + + + + + + + + + + + + + + P h e o c h r o m o c y t o m a   m a l i g n a n t X P h e o c h r o m o c y t o m a   c o m p l e x X P h e o c h r o m o c y t o m a   b e n i g n X X X X X X B i l a t e r a l ,   p h e o c h r o m o c y t o m a   b e n i g n X I s l e t s ,   p a n c r e a t i c + + + + + + + + + + + + + + + + + + + + + + + + + A d e n o m a X P a r a t h y r o i d   g l a n d + + + + + + + + M + + + + + + + M + + + + + M + M P i t u i t a r y   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + P a r s   d i s t a l i s ,   a d e n o m a X X X X X X X X X X X X X X X X P a r s   d i s t a l i s ,   c a r c i n o m a X P a r s   i n t e r m e d i a ,   a d e n o m a X T h y r o i d   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + B i l a t e r a l ,   C - c e l l ,   a d e n o m a C - c e l l ,   a d e n o m a X X X C - c e l l ,   c a r c i n o m a X X F o l l i c u l a r   c e l l ,   a d e n o m a I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 1 7 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 0 3   m g / m 3 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 T o t a l C a r c a s s   I D   N u m b e r 1 1 1 2 2 2 2 3 4 4 0 1 1 2 3 4 4 4 4 4 0 0 1 2 4 T i s s u e s / 5 7 9 0 1 2 8 9 0 2 7 0 8 3 0 4 5 6 7 8 3 8 1 6 9 T u m o r s A l i m e n t a r y   S y s t e m           E s o p h a g u s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S q u a m o u s   c e l l   p a p i l l o m a   1 I n t e s t i n e   l a r g e ,   c o l o n + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 I n t e s t i n e   l a r g e ,   r e c t u m + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 I n t e s t i n e   l a r g e ,   c e c u m + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 I n t e s t i n e   s m a l l ,   d u o d e n u m + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 I n t e s t i n e   s m a l l ,   j e j u n u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 8 C a r c i n o m a X   1 I n t e s t i n e   s m a l l ,   i l e u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 L i v e r + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 C h o l a n g i o c a r c i n o m a X   1 C h o l a n g i o m a   1 H i s t i o c y t i c   s a r c o m a   1 M e s e n t e r y + +   6 P a n c r e a s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 H i s t i o c y t i c   s a r c o m a   1 S a l i v a r y   g l a n d s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S t o m a c h ,   f o r e s t o m a c h + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S t o m a c h ,   g l a n d u l a r + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 C a r d i o v a s c u l a r   S y s t e m   H e a r t + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   1 E n d o c r i n e   S y s t e m             A d r e n a l   c o r t e x + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d e n o m a   1 C a r c i n o m a   1 A d r e n a l   m e d u l l a + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 P h e o c h r o m o c y t o m a   m a l i g n a n t X X   3 P h e o c h r o m o c y t o m a   c o m p l e x   1 P h e o c h r o m o c y t o m a   b e n i g n X X X X X X X X X X 1 6 B i l a t e r a l ,   p h e o c h r o m o c y t o m a   b e n i g n X X X X X   6 I s l e t s ,   p a n c r e a t i c + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d e n o m a X   2 P a r a t h y r o i d   g l a n d + + + + + + + + + + + + + + M + + + + + + M + + + 4 4 P i t u i t a r y   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 P a r s   d i s t a l i s ,   a d e n o m a X X X X X X X X X X X X X X X X X 3 3 P a r s   d i s t a l i s ,   c a r c i n o m a   1 P a r s   i n t e r m e d i a ,   a d e n o m a   1 T h y r o i d   g l a n d + + + + + + + + + + + + + + + + + + + + + M + + + 4 9 B i l a t e r a l ,   C - c e l l ,   a d e n o m a X   1 C - c e l l ,   a d e n o m a X X X X   7 C - c e l l ,   c a r c i n o m a X X   4 F o l l i c u l a r   c e l l ,   a d e n o m a X   1 1 1 8 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 0 3   m g / m 3 2 5 5 5 5 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 8 2 6 7 8 2 3 4 5 8 8 8 8 9 0 0 0 0 1 1 2 3 3 3 3 5 6 9 6 6 8 5 3 8 3 4 5 6 5 0 1 2 7 4 4 3 3 3 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 C a r c a s s   I D   N u m b e r 3 5 3 4 4 0 2 3 0 2 1 3 3 3 2 3 2 3 0 1 0 0 0 1 1 8 0 4 1 3 5 5 1 6 7 2 6 3 7 4 2 9 5 9 6 2 1 4 3 4 G e n e r a l   B o d y   S y s t e m       P e r i t o n e u m + H i s t i o c y t i c   s a r c o m a X G e n i t a l   S y s t e m                 E p i d i d y m i s + + + + + + + + + + + + + + + + + + + + + + + + + H i s t i o c y t i c   s a r c o m a X P r e p u t i a l   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + A d e n o m a X P r o s t a t e + + + + + + + + + + + + + + + + + + + + + + + + + A d e n o m a X S e m i n a l   v e s i c l e + + + + + + + + + + + + + + + A + + + + + + + + + A d e n o m a H i s t i o c y t i c   s a r c o m a X T e s t e s + + + + + + + + + + + + + + + + + + + + + + + + + B i l a t e r a l ,   i n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X X X X I n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X H e m a t o p o i e t i c   S y s t e m     B o n e   m a r r o w + + + + + + + + + + + + + + + + + + + + + + + + + L y m p h   n o d e + + L y m p h   n o d e ,   b r o n c h i a l M M + + + + + + + + M + M M + + M M + + M M + M + H i s t i o c y t i c   s a r c o m a X L y m p h   n o d e ,   m a n d i b u l a r + M + M M + + + + + + + M + + + M + + + + + + + + L y m p h   n o d e ,   m e s e n t e r i c + + + + + + + + + + + + + + + + + + + + + + + + + L y m p h   n o d e ,   m e d i a s t i n a l + M + + + + + + M M M + M M + M M + + + M M M M M S p l e e n + + + + + + + + + + + + + + + + + + + + + + + + + T h y m u s + + + + + + + + + + M M + + + + + + + + + + + + + I n t e g u m e n t a r y   S y s t e m     M a m m a r y   g l a n d + M + + + M + M + + M M M + M + + + + + + M + M + F i b r o a d e n o m a S k i n + + + + + + + + + + + + + + + + + + + + + + + + + H i s t i o c y t i c   s a r c o m a X K e r a t o a c a n t h o m a K e r a t o a c a n t h o m a ,   m u l t i p l e X S e b a c e o u s   g l a n d ,   a d e n o m a S u b c u t a n e o u s   t i s s u e ,   f i b r o m a X X S u b c u t a n e o u s   t i s s u e ,   f i b r o s a r c o m a X X S u b c u t a n e o u s   t i s s u e ,   l i p o m a M u s c u l o s k e l e t a l   S y s t e m B o n e + + + + + + + + + + + + + + + + + + + + + + + + + F i b r o s a r c o m a ,   m e t a s t a t i c ,   s k i n X N e r v o u s   S y s t e m                 B r a i n + + + + + + + + + + + + + + + + + + + + + + + + + G l i o m a   b e n i g n X H i s t i o c y t i c   s a r c o m a X I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 1 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 0 3   m g / m 3 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 T o t a l C a r c a s s   I D   N u m b e r 1 1 1 2 2 2 2 3 4 4 0 1 1 2 3 4 4 4 4 4 0 0 1 2 4 T i s s u e s / 5 7 9 0 1 2 8 9 0 2 7 0 8 3 0 4 5 6 7 8 3 8 1 6 9 T u m o r s G e n e r a l   B o d y   S y s t e m       P e r i t o n e u m   1 H i s t i o c y t i c   s a r c o m a   1 G e n i t a l   S y s t e m                 E p i d i d y m i s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 H i s t i o c y t i c   s a r c o m a   1 P r e p u t i a l   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d e n o m a X   2 P r o s t a t e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d e n o m a X   2 S e m i n a l   v e s i c l e + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 A d e n o m a X   1 H i s t i o c y t i c   s a r c o m a   1 T e s t e s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 B i l a t e r a l ,   i n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X X X X X X X X X X X 2 5 I n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X 1 0 H e m a t o p o i e t i c   S y s t e m     B o n e   m a r r o w + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L y m p h   n o d e + +   4 L y m p h   n o d e ,   b r o n c h i a l M M M + + + M + + + + M M M + + + M M + M M + M M 2 7 H i s t i o c y t i c   s a r c o m a   1 L y m p h   n o d e ,   m a n d i b u l a r + + M + + + + + + + + + M + + + + + + + M + + + + 4 2 L y m p h   n o d e ,   m e s e n t e r i c + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L y m p h   n o d e ,   m e d i a s t i n a l M M M M M M M + + + M M M M M + + M M + M M + M M 1 9 S p l e e n + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 T h y m u s + + M + + + + + + + + + + + + + + + + + + + + + + 4 7 I n t e g u m e n t a r y   S y s t e m     M a m m a r y   g l a n d + M M M + + + + + + + M + M + M + M + + M + + + + 3 3 F i b r o a d e n o m a X   1 S k i n + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 H i s t i o c y t i c   s a r c o m a   1 K e r a t o a c a n t h o m a X X X   3 K e r a t o a c a n t h o m a ,   m u l t i p l e   1 S e b a c e o u s   g l a n d ,   a d e n o m a X   1 S u b c u t a n e o u s   t i s s u e ,   f i b r o m a X X   4 S u b c u t a n e o u s   t i s s u e ,   f i b r o s a r c o m a   2 S u b c u t a n e o u s   t i s s u e ,   l i p o m a X   1 M u s c u l o s k e l e t a l   S y s t e m B o n e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 F i b r o s a r c o m a ,   m e t a s t a t i c ,   s k i n   1 N e r v o u s   S y s t e m                 B r a i n + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 G l i o m a   b e n i g n   1 H i s t i o c y t i c   s a r c o m a   1 1 2 0 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 0 3   m g / m 3 2 5 5 5 5 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 8 2 6 7 8 2 3 4 5 8 8 8 8 9 0 0 0 0 1 1 2 3 3 3 3 5 6 9 6 6 8 5 3 8 3 4 5 6 5 0 1 2 7 4 4 3 3 3 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 C a r c a s s   I D   N u m b e r 3 5 3 4 4 0 2 3 0 2 1 3 3 3 2 3 2 3 0 1 0 0 0 1 1 8 0 4 1 3 5 5 1 6 7 2 6 3 7 4 2 9 5 9 6 2 1 4 3 4 R e s p i r a t o r y   S y s t e m         L a r y n x + + + + + + + + + + + + + + + + + + + + + + + + + C a r c i n o m a ,   m e t a s t a t i c ,   t h y r o i d   g l a n d X L u n g + + + + + + + + + + + + + + + + + + + + + + + + + A l v e o l a r / b r o n c h i o l a r   a d e n o m a X X X X A l v e o l a r / b r o n c h i o l a r   a d e n o m a ,   m u l t i p l e X A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a X X X X X A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m u l t i p l e   C a r c i n o m a ,   m e t a s t a t i c ,   p i t u i t a r y   g l a n d X C a r c i n o m a ,   m e t a s t a t i c ,   t h y r o i d   g l a n d X H i s t i o c y t i c   s a r c o m a X P h e o c h r o m o c y t o m a   m a l i g n a n t ,   m e t a s t a t i c ,       a d r e n a l   m e d u l l a   N o s e + + + + + + + + + + + + + + + + + + + + + + + + + P l e u r a + + A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X H i s t i o c y t i c   s a r c o m a X T r a c h e a + + + + + + + + + + + + + + + + + + + + + + + + + S p e c i a l   S e n s e s   S y s t e m   E y e + Z y m b a l ’ s   g l a n d C a r c i n o m a U r i n a r y   S y s t e m                 K i d n e y + + + + + + + + + + + + + + + + + + + + + + + + + H i s t i o c y t i c   s a r c o m a X U r i n a r y   b l a d d e r + + + + + + + + + + + + + + + + + + + + + + + + + S y s t e m i c   L e s i o n s             M u l t i p l e   o r g a n s + + + + + + + + + + + + + + + + + + + + + + + + + H i s t i o c y t i c   s a r c o m a X X X L e u k e m i a   m o n o n u c l e a r X X X X X X X X X X X I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 2 1 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 0 3   m g / m 3 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 T o t a l C a r c a s s   I D   N u m b e r 1 1 1 2 2 2 2 3 4 4 0 1 1 2 3 4 4 4 4 4 0 0 1 2 4 T i s s u e s / 5 7 9 0 1 2 8 9 0 2 7 0 8 3 0 4 5 6 7 8 3 8 1 6 9 T u m o r s R e s p i r a t o r y   S y s t e m         L a r y n x + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 C a r c i n o m a ,   m e t a s t a t i c ,   t h y r o i d   g l a n d   1 L u n g + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A l v e o l a r / b r o n c h i o l a r   a d e n o m a X X X X   8 A l v e o l a r / b r o n c h i o l a r   a d e n o m a ,   m u l t i p l e   X X X X     5 A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a X X X   8 A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m u l t i p l e   X X     2 C a r c i n o m a ,   m e t a s t a t i c ,   p i t u i t a r y   g l a n d     1 C a r c i n o m a ,   m e t a s t a t i c ,   t h y r o i d   g l a n d   1 H i s t i o c y t i c   s a r c o m a   1 P h e o c h r o m o c y t o m a   m a l i g n a n t ,   m e t a s t a t i c ,         a d r e n a l   m e d u l l a X           1 N o s e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 P l e u r a   2 A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   1 H i s t i o c y t i c   s a r c o m a   1 T r a c h e a + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S p e c i a l   S e n s e s   S y s t e m   E y e   1 Z y m b a l ’ s   g l a n d +   1 C a r c i n o m a X   1 U r i n a r y   S y s t e m                 K i d n e y + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 H i s t i o c y t i c   s a r c o m a   1 U r i n a r y   b l a d d e r + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S y s t e m i c   L e s i o n s             M u l t i p l e   o r g a n s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 H i s t i o c y t i c   s a r c o m a   3 L e u k e m i a   m o n o n u c l e a r X X X X X X X X X X X X 2 3 1 2 2 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :   0 . 1   m g / m 3   ( S t o p - E x p o s u r e ) 4 4 4 4 5 5 5 6 6 6 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 0 3 6 9 1 3 5 0 3 4 4 4 5 5 5 6 6 7 9 0 1 3 3 3 3 3 5 0 3 3 7 2 2 0 4 4 9 1 6 8 5 7 9 8 0 0 3 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 C a r c a s s   I D   N u m b e r 3 4 3 0 2 2 0 4 3 2 4 5 4 2 1 2 0 1 2 1 1 0 0 0 1 6 7 1 2 7 9 4 1 3 2 9 0 8 5 0 1 3 9 4 4 7 1 5 8 3 A l i m e n t a r y   S y s t e m           E s o p h a g u s + + + + + + + + + + + + + + + + + + + + + + + + + I n t e s t i n e   l a r g e ,   c o l o n + + + A + + + + + + + + + + + A + + + + A + + + + P o l y p   a d e n o m a t o u s I n t e s t i n e   l a r g e ,   r e c t u m + + + A + + + + + + + + + + + A + + + + + + + + + I n t e s t i n e   l a r g e ,   c e c u m + + + A + + + + A + + + + + + A + + + + A + + + + I n t e s t i n e   s m a l l ,   d u o d e n u m + + + A + + + + A + + + + + + A + + + + + + + + + I n t e s t i n e   s m a l l ,   j e j u n u m + + + A A + + + A + + + + + + A + + + + + + + + + I n t e s t i n e   s m a l l ,   i l e u m + + + A + + + + A + + + + + + A + + + + A + + + + L i v e r + + + + + + + + + + + + + + + + + + + + + + + + + H e p a t o c e l l u l a r   a d e n o m a X M e s e n t e r y + + + O r a l   m u c o s a + G i n g i v a l ,   s q u a m o u s   c e l l   p a p i l l o m a P h a r y n g e a l ,   s q u a m o u s   c e l l   p a p i l l o m a X P a n c r e a s + + + + + + + + + + + + + + + + + + + + + + + + + S a l i v a r y   g l a n d s + + + + + + + + + + + + + + + + + + + + + + + + + S t o m a c h ,   f o r e s t o m a c h + + + + + + + + + + + + + + + + + + + + + + + + + L e i o m y o s a r c o m a S t o m a c h ,   g l a n d u l a r + + + A + + + + + + + + + + + A + + + + + + + + + T o o t h C a r d i o v a s c u l a r   S y s t e m   H e a r t + + + + + + + + + + + + + + + + + + + + + + + + + P e r i c a r d i u m ,   a l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,     m e t a s t a t i c ,   l u n g   E n d o c r i n e   S y s t e m             A d r e n a l   c o r t e x + + + + + + + + + + + + + + + + + + + + + + + + + A d r e n a l   m e d u l l a + + + + + + + + + + + + + + + + + + + + + + + + + P h e o c h r o m o c y t o m a   m a l i g n a n t X P h e o c h r o m o c y t o m a   b e n i g n X X X X X X B i l a t e r a l ,   p h e o c h r o m o c y t o m a   b e n i g n X I s l e t s ,   p a n c r e a t i c + + + + + + + + + + + + + + + + + + + + + + + + + A d e n o m a C a r c i n o m a X X P a r a t h y r o i d   g l a n d + + + + + M + + + + + + + + + + + + + + + + + + + P i t u i t a r y   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + P a r s   d i s t a l i s ,   a d e n o m a X X X X X X X X X X X X X X T h y r o i d   g l a n d + + + A + + + + A + + + + + + + + + + + + + + + + C - c e l l ,   a d e n o m a X C - c e l l ,   c a r c i n o m a G e n e r a l   B o d y   S y s t e m       N o n e I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 2 3 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :   0 . 1   m g / m 3   ( S t o p - E x p o s u r e ) 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 5 5 5 5 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 T o t a l C a r c a s s   I D   N u m b e r 1 2 2 2 3 4 0 0 0 1 1 1 2 3 3 3 3 3 4 4 4 1 3 4 4 T i s s u e s / 5 0 3 6 8 6 6 7 9 1 2 8 8 2 4 5 7 9 2 3 5 6 0 0 4 T u m o r s A l i m e n t a r y   S y s t e m           E s o p h a g u s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 I n t e s t i n e   l a r g e ,   c o l o n + + + + + + + + + + + + + + + + + + + + + + + + + 4 7 P o l y p   a d e n o m a t o u s X   1 I n t e s t i n e   l a r g e ,   r e c t u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 8 I n t e s t i n e   l a r g e ,   c e c u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 6 I n t e s t i n e   s m a l l ,   d u o d e n u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 7 I n t e s t i n e   s m a l l ,   j e j u n u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 6 I n t e s t i n e   s m a l l ,   i l e u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 6 L i v e r + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 H e p a t o c e l l u l a r   a d e n o m a   1 M e s e n t e r y + + +   6 O r a l   m u c o s a + +   3 G i n g i v a l ,   s q u a m o u s   c e l l   p a p i l l o m a X X   2 P h a r y n g e a l ,   s q u a m o u s   c e l l   p a p i l l o m a   1 P a n c r e a s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S a l i v a r y   g l a n d s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S t o m a c h ,   f o r e s t o m a c h + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L e i o m y o s a r c o m a X   1 S t o m a c h ,   g l a n d u l a r + + + + + + + + + + + + + + + + + + + + + + + + + 4 8 T o o t h + + +   3 C a r d i o v a s c u l a r   S y s t e m   H e a r t + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 P e r i c a r d i u m ,   a l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,       m e t a s t a t i c ,   l u n g X 1 E n d o c r i n e   S y s t e m             A d r e n a l   c o r t e x + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d r e n a l   m e d u l l a + + + + + + + + + + + + + + + + + + + + + + + I + 4 9 P h e o c h r o m o c y t o m a   m a l i g n a n t X X   3 P h e o c h r o m o c y t o m a   b e n i g n X X X X X X 1 2 B i l a t e r a l ,   p h e o c h r o m o c y t o m a   b e n i g n X X X   4 I s l e t s ,   p a n c r e a t i c + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d e n o m a X X   2 C a r c i n o m a X X   4 P a r a t h y r o i d   g l a n d M + + + + + + + + + + + + + + M + M + + + + + + M 4 5 P i t u i t a r y   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 P a r s   d i s t a l i s ,   a d e n o m a X X X X X X X X X X X X X X X X X 3 1 T h y r o i d   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + 4 8 C - c e l l ,   a d e n o m a X X X   4 C - c e l l ,   c a r c i n o m a X X X   3 G e n e r a l   B o d y   S y s t e m       N o n e   1 2 4 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 1   m g / m 3   ( S t o p - E x p o s u r e )     4 4 4 4 5 5 5 6 6 6 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 0 3 6 9 1 3 5 0 3 4 4 4 5 5 5 6 6 7 9 0 1 3 3 3 3 3 5 0 3 3 7 2 2 0 4 4 9 1 6 8 5 7 9 8 0 0 3 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 C a r c a s s   I D   N u m b e r 3 4 3 0 2 2 0 4 3 2 4 5 4 2 1 2 0 1 2 1 1 0 0 0 1 6 7 1 2 7 9 4 1 3 2 9 0 8 5 0 1 3 9 4 4 7 1 5 8 3 G e n i t a l   S y s t e m                 C o a g u l a t i n g   g l a n d E p i d i d y m i s + + + + + + + + + + + + + + + + + + + + + + + + + P r e p u t i a l   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + C a r c i n o m a P r o s t a t e + + + + + + + + + + + + + + + + + + + + + + + + + A d e n o m a X A d e n o m a ,   m u l t i p l e X S e m i n a l   v e s i c l e + + + A + + + + A + + + + + + + + + + + + + + + + T e s t e s + + + + + + + + + + + + + + + + + + + + + + + + + B i l a t e r a l ,   i n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X X X I n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X X X H e m a t o p o i e t i c   S y s t e m     B o n e   m a r r o w + + + + + + + + A + + + + + + + + + + + + + + + + L y m p h   n o d e ,   b r o n c h i a l + + M + M M + + + + + M + M + + M M + + + + + + + L y m p h   n o d e ,   m a n d i b u l a r + + + + + + + + + + + + + + + + + + + + + + + + + L y m p h   n o d e ,   m e s e n t e r i c + + + + + + + + + + + + + + + + I + + + + + + + + L y m p h   n o d e ,   m e d i a s t i n a l + + + + + + + + + + + + + + M + M + + + M + + + + S p l e e n + + + A + + + + + + + + + + + + + + + + + + + + + T h y m u s + I + + + I + + + + + + M + + + + + + + + + + + + I n t e g u m e n t a r y   S y s t e m     M a m m a r y   g l a n d + + + + + M + M M M + M + M M + M + + + + M M M + C a r c i n o m a S k i n + + + + + + + + + + + + + + + + + + + + + + + + + K e r a t o a c a n t h o m a T r i c h o e p i t h e l i o m a S u b c u t a n e o u s   t i s s u e ,   f i b r o m a X S u b c u t a n e o u s   t i s s u e ,   f i b r o s a r c o m a S u b c u t a n e o u s   t i s s u e ,   l i p o m a X S u b c u t a n e o u s   t i s s u e ,   l i p o s a r c o m a M u s c u l o s k e l e t a l   S y s t e m B o n e + + + + + + + + + + + + + + + + + + + + + + + + + O s t e o m a X O s t e o s a r c o m a X S k e l e t a l   m u s c l e + R h a b d o m y o s a r c o m a X N e r v o u s   S y s t e m                 B r a i n + + + + + + + + + + + + + + + + + + + + + + + + + S p i n a l   c o r d + I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 2 5 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 1   m g / m 3   ( S t o p - E x p o s u r e ) 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 5 5 5 5 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 T o t a l C a r c a s s   I D   N u m b e r 1 2 2 2 3 4 0 0 0 1 1 1 2 3 3 3 3 3 4 4 4 1 3 4 4 T i s s u e s / 5 0 3 6 8 6 6 7 9 1 2 8 8 2 4 5 7 9 2 3 5 6 0 0 4 T u m o r s G e n i t a l   S y s t e m                 C o a g u l a t i n g   g l a n d +   1 E p i d i d y m i s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 P r e p u t i a l   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 C a r c i n o m a X   1 P r o s t a t e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d e n o m a   1 A d e n o m a ,   m u l t i p l e   1 S e m i n a l   v e s i c l e + + + + + + + + + + + + + + + + + + + + + + + + + 4 8 T e s t e s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 B i l a t e r a l ,   i n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X X X X X X X X X X X X X 2 6 I n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X X 1 5 H e m a t o p o i e t i c   S y s t e m     B o n e   m a r r o w + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 L y m p h   n o d e ,   b r o n c h i a l + + + + + + + M + + + + + + + + + + + + + M + + + 4 1 L y m p h   n o d e ,   m a n d i b u l a r + M + M + + + + + + + + M + + + + + + + + + + + + 4 7 L y m p h   n o d e ,   m e s e n t e r i c + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 L y m p h   n o d e ,   m e d i a s t i n a l + + + + + + M + + + + + + + + + + + + + + + + M + 4 5 S p l e e n + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 T h y m u s + M + + + + + + + + + + + + + + + + + + + + + + + 4 6 I n t e g u m e n t a r y   S y s t e m     M a m m a r y   g l a n d + + M M + + + + + + + M M + + M + M M + + + + + I 3 1 C a r c i n o m a X   1 S k i n + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 K e r a t o a c a n t h o m a X X X X X   5 T r i c h o e p i t h e l i o m a X   1 S u b c u t a n e o u s   t i s s u e ,   f i b r o m a X X X X X X   7 S u b c u t a n e o u s   t i s s u e ,   f i b r o s a r c o m a X   1 S u b c u t a n e o u s   t i s s u e ,   l i p o m a X   2 S u b c u t a n e o u s   t i s s u e ,   l i p o s a r c o m a X   1 M u s c u l o s k e l e t a l   S y s t e m B o n e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 O s t e o m a   1 O s t e o s a r c o m a   1 S k e l e t a l   m u s c l e   1 R h a b d o m y o s a r c o m a   1 N e r v o u s   S y s t e m                 B r a i n + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S p i n a l   c o r d   1 1 2 6 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 1   m g / m 3   ( S t o p - E x p o s u r e ) 4 4 4 4 5 5 5 6 6 6 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 0 3 6 9 1 3 5 0 3 4 4 4 5 5 5 6 6 7 9 0 1 3 3 3 3 3 5 0 3 3 7 2 2 0 4 4 9 1 6 8 5 7 9 8 0 0 3 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 C a r c a s s   I D   N u m b e r 3 4 3 0 2 2 0 4 3 2 4 5 4 2 1 2 0 1 2 1 1 0 0 0 1 6 7 1 2 7 9 4 1 3 2 9 0 8 5 0 1 3 9 4 4 7 1 5 8 3 R e s p i r a t o r y   S y s t e m   L a r y n x + + + + + + + + + + + + + + + + + + + + + + + + + L u n g + + + + + + + + + + + + + + + + + + + + + + + + + A l v e o l a r / b r o n c h i o l a r   a d e n o m a X X X X X X X X A l v e o l a r / b r o n c h i o l a r   a d e n o m a ,   m u l t i p l e X X   A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a X A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m u l t i p l e             N o s e + + + + + + + + + + + + + + + + + + + + + + + + + E s t h e s i o n e u r o b l a s t o m a X O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e X T r a c h e a + + + A + + + + + + + + + + + + + + + + + + + + + S p e c i a l   S e n s e s   S y s t e m   E y e Z y m b a l ’ s   g l a n d + C a r c i n o m a X U r i n a r y   S y s t e m                 K i d n e y + + + + + + + + + + + + + + + + + + + + + + + + + L i p o s a r c o m a U r i n a r y   b l a d d e r + + + + + + + + M + + + + + + + + + + + + + + + + T r a n s i t i o n a l   e p i t h e l i u m ,   p a p i l l o m a X S y s t e m i c   L e s i o n s             M u l t i p l e   o r g a n s + + + + + + + + + + + + + + + + + + + + + + + + + L e u k e m i a   m o n o n u c l e a r X X X X X X X X X X X X X X X X M e s o t h e l i o m a   m a l i g n a n t X I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 2 7 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 1   m g / m 3   ( S t o p - E x p o s u r e ) 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 5 5 5 5 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 T o t a l C a r c a s s   I D   N u m b e r 1 2 2 2 3 4 0 0 0 1 1 1 2 3 3 3 3 3 4 4 4 1 3 4 4 T i s s u e s / 5 0 3 6 8 6 6 7 9 1 2 8 8 2 4 5 7 9 2 3 5 6 0 0 4 T u m o r s R e s p i r a t o r y   S y s t e m L a r y n x + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L u n g + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A l v e o l a r / b r o n c h i o l a r   a d e n o m a X X X X X X X X X X X 1 9 A l v e o l a r / b r o n c h i o l a r   a d e n o m a ,   m u l t i p l e X X X X X X     8 A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a X X X X X X   7 A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m u l t i p l e X   1 N o s e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 E s t h e s i o n e u r o b l a s t o m a   1 O s t e o s a r c o m a ,   m e t a s t a t i c ,   b o n e   1 T r a c h e a + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 S p e c i a l   S e n s e s   S y s t e m   E y e +   1 Z y m b a l ’ s   g l a n d   1 C a r c i n o m a   1 U r i n a r y   S y s t e m                 K i d n e y + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L i p o s a r c o m a X   1 U r i n a r y   b l a d d e r + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 T r a n s i t i o n a l   e p i t h e l i u m ,   p a p i l l o m a   1 S y s t e m i c   L e s i o n s             M u l t i p l e   o r g a n s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L e u k e m i a   m o n o n u c l e a r X X X X X X X X X X X X X 2 9 M e s o t h e l i o m a   m a l i g n a n t   1 1 2 8 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 3   m g / m 3   ( S t o p - E x p o s u r e ) 5 5 5 5 5 5 5 6 6 6 6 6 6 6 6 6 6 6 6 6 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 2 3 3 4 4 6 6 0 2 5 5 5 7 7 7 7 7 8 8 9 0 2 2 3 3 5 0 2 5 7 0 0 3 1 6 8 8 1 2 2 6 6 4 6 5 6 8 8 0 3 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 C a r c a s s   I D   N u m b e r 2 4 2 1 0 0 2 4 4 2 3 5 3 3 3 0 1 0 3 1 4 2 4 1 0 9 3 0 6 4 8 5 5 9 8 3 0 0 1 7 1 9 6 9 2 1 6 6 7 3 A l i m e n t a r y   S y s t e m           E s o p h a g u s + + + + + + + + + + + + + + + + + + + + + + + + + I n t e s t i n e   l a r g e ,   c o l o n + + + + A + + + A + + + + + + + + + + + + + + + + I n t e s t i n e   l a r g e ,   r e c t u m + + + + A + + + + + + + + + + + + + + + + + + + + I n t e s t i n e   l a r g e ,   c e c u m + + + + A + + + A + + + A + + + + + + + + + + A + I n t e s t i n e   s m a l l ,   d u o d e n u m + + + + A + + + A + + + + + + + + + + + + + + + + I n t e s t i n e   s m a l l ,   j e j u n u m + + + + A + + A A + + + A + + A + A + + + + + A + I n t e s t i n e   s m a l l ,   i l e u m + + + + A + A + A + + + A + + A + + + + + + + A + L i v e r + + + + + + + + + + + + + + + + + + + + + + + + + C h o l a n g i o c a r c i n o m a M e s e n t e r y + + + + + + S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X O r a l   m u c o s a + P h a r y n g e a l ,   s q u a m o u s   c e l l   p a p i l l o m a P a n c r e a s + + + + + + + + + + + + + + + + + + + + + + + + + S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X S a l i v a r y   g l a n d s + + + + + + + + + + + + + + + + + + + + + + + + + S t o m a c h ,   f o r e s t o m a c h + + + + + + + + + + + + + + + + + + + + + + + + + S t o m a c h ,   g l a n d u l a r + + + + + + + + A + + + + + + + + + + + + + + + + T o o t h + C a r d i o v a s c u l a r   S y s t e m   H e a r t + + + + + + + + + + + + + + + + + + + + + + + + + A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X   S c h w a n n o m a   b e n i g n S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X   E n d o c r i n e   S y s t e m             A d r e n a l   c o r t e x + + + + + + + + + + + + + + + + + + + + + + + + + S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X A d r e n a l   m e d u l l a + + + + + + + + + + + + + + + + + + + + + + + + + P h e o c h r o m o c y t o m a   m a l i g n a n t X P h e o c h r o m o c y t o m a   b e n i g n X X X X X S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   X B i l a t e r a l ,   p h e o c h r o m o c y t o m a   b e n i g n X X X I s l e t s ,   p a n c r e a t i c + + + + + + + + + + + + + + + + + + + + + + + + + A d e n o m a X C a r c i n o m a X X S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X P a r a t h y r o i d   g l a n d + M + + + + + + + + + + + + + + M + + + + + + M + P i t u i t a r y   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + P a r s   d i s t a l i s ,   a d e n o m a X X X X X X X X X X X X X X X T h y r o i d   g l a n d + + + + + + + + A + + + + + + + + + + + + + + A + C - c e l l ,   a d e n o m a X X X C - c e l l ,   c a r c i n o m a I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 2 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 3   m g / m 3   ( S t o p - E x p o s u r e ) 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 T o t a l C a r c a s s   I D   N u m b e r 0 1 1 1 1 1 1 2 2 3 3 4 0 0 2 3 3 4 4 4 4 0 2 2 3 T i s s u e s / 5 0 1 3 4 5 8 3 4 2 6 4 2 9 7 5 8 0 2 7 8 7 1 2 4   T u m o r s A l i m e n t a r y   S y s t e m           E s o p h a g u s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 I n t e s t i n e   l a r g e ,   c o l o n + + + + + + + + + + + + + + + + + + + + + + + + + 4 8 I n t e s t i n e   l a r g e ,   r e c t u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 I n t e s t i n e   l a r g e ,   c e c u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 6 I n t e s t i n e   s m a l l ,   d u o d e n u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 8 I n t e s t i n e   s m a l l ,   j e j u n u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 3 I n t e s t i n e   s m a l l ,   i l e u m + + + + + + + + + + + + + + + + + + + + + + + + + 4 4 L i v e r + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 C h o l a n g i o c a r c i n o m a X   1 M e s e n t e r y + +   8 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   1 O r a l   m u c o s a +   2 P h a r y n g e a l ,   s q u a m o u s   c e l l   p a p i l l o m a X   1 P a n c r e a s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   1 S a l i v a r y   g l a n d s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S t o m a c h ,   f o r e s t o m a c h + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S t o m a c h ,   g l a n d u l a r + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 T o o t h   1 C a r d i o v a s c u l a r   S y s t e m   H e a r t + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g       1 S c h w a n n o m a   b e n i g n X   1 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   1 E n d o c r i n e   S y s t e m             A d r e n a l   c o r t e x + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   1 A d r e n a l   m e d u l l a + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 P h e o c h r o m o c y t o m a   m a l i g n a n t   1 P h e o c h r o m o c y t o m a   b e n i g n X X X X X X X X X X X X X 1 8 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   1 B i l a t e r a l ,   p h e o c h r o m o c y t o m a   b e n i g n X X   5 I s l e t s ,   p a n c r e a t i c + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d e n o m a X X   3 C a r c i n o m a X   3 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   1 P a r a t h y r o i d   g l a n d + + + M + + M + + + + + + + + + + + + + + + + + + 4 5 P i t u i t a r y   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 P a r s   d i s t a l i s ,   a d e n o m a X X X X X X X X X X X X X X X 3 0 T h y r o i d   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + 4 8 C - c e l l ,   a d e n o m a X X X X X X   9 C - c e l l ,   c a r c i n o m a X   1 1 3 0 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 3   m g / m 3   ( S t o p - E x p o s u r e ) 5 5 5 5 5 5 5 6 6 6 6 6 6 6 6 6 6 6 6 6 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 2 3 3 4 4 6 6 0 2 5 5 5 7 7 7 7 7 8 8 9 0 2 2 3 3 5 0 2 5 7 0 0 3 1 6 8 8 1 2 2 6 6 4 6 5 6 8 8 0 3 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 C a r c a s s   I D   N u m b e r 2 4 2 1 0 0 2 4 4 2 3 5 3 3 3 0 1 0 3 1 4 2 4 1 0 9 3 0 6 4 8 5 5 9 8 3 0 0 1 7 1 9 6 9 2 1 6 6 7 3 G e n e r a l   B o d y   S y s t e m       T i s s u e   N O S + C h e m o d e c t o m a   m a l i g n a n t X G e n i t a l   S y s t e m                 E p i d i d y m i s + + + + + + + + + + + + + + + + + + + + + + + + + P e n i s + P r e p u t i a l   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + P r o s t a t e + + + + + + + + + + + + + + + + + + + + + + + + + A d e n o m a S e m i n a l   v e s i c l e + + + + + + + + A + + + + + + + + + + + + + + + + T e s t e s + + + + + + + + + + + + + + + + + + + + + + + + + B i l a t e r a l ,   i n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X I n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X H e m a t o p o i e t i c   S y s t e m     B o n e   m a r r o w + + + + + + + + + + + + + + + + + + + + + + + + + L y m p h   n o d e + + R e n a l ,   s q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X                 L y m p h   n o d e ,   b r o n c h i a l + + + + + + + + + + + M M + M + M + + M + M + + + S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X L y m p h   n o d e ,   m a n d i b u l a r M + + + + + + + + + + + M + M + + + + + + + + + + S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X L y m p h   n o d e ,   m e s e n t e r i c + + + + + + + + + + + + + + + + + + + + + + + + + L y m p h   n o d e ,   m e d i a s t i n a l + + + + + + + + + + + M M + M M + M + M + + M M + S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X X   S p l e e n + + + + A + + + A + + + + + + + + + + + + + + + + T h y m u s + M + M + + + + + + M + M + + + + + + M + + + + + I n t e g u m e n t a r y   S y s t e m     M a m m a r y   g l a n d + + M M M M M M + + + + M M M + + M + M + M + M M C a r c i n o m a F i b r o a d e n o m a S k i n + + + + + + + + + + + + + + + + + I + + + + + + + K e r a t o a c a n t h o m a S q u a m o u s   c e l l   p a p i l l o m a X S u b c u t a n e o u s   t i s s u e ,   f i b r o m a X X S u b c u t a n e o u s   t i s s u e ,   f i b r o s a r c o m a X S u b c u t a n e o u s   t i s s u e ,   l i p o m a X M u s c u l o s k e l e t a l   S y s t e m B o n e + + + + + + + + + + + + + + + + + + + + + + + + + O s t e o s a r c o m a X N e r v o u s   S y s t e m                 B r a i n + + + + + + + + + + + + + + + + + + + + + + + + + I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 3 1 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 3   m g / m 3   ( S t o p - E x p o s u r e ) 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6   T o t a l C a r c a s s   I D   N u m b e r 0 1 1 1 1 1 1 2 2 3 3 4 0 0 2 3 3 4 4 4 4 0 2 2 3 T i s s u e s / 5 0 1 3 4 5 8 3 4 2 6 4 2 9 7 5 8 0 2 7 8 7 1 2 4 T u m o r s G e n e r a l   B o d y   S y s t e m       T i s s u e   N O S   1 C h e m o d e c t o m a   m a l i g n a n t   1 G e n i t a l   S y s t e m                 E p i d i d y m i s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 P e n i s   1 P r e p u t i a l   g l a n d + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 P r o s t a t e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A d e n o m a X X   2 S e m i n a l   v e s i c l e + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 T e s t e s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 B i l a t e r a l ,   i n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X X X X X X 1 7 I n t e r s t i t i a l   c e l l ,   a d e n o m a X X X X X X X X X X X 1 6 H e m a t o p o i e t i c   S y s t e m     B o n e   m a r r o w + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L y m p h   n o d e   2 R e n a l ,   s q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g 1 L y m p h   n o d e ,   b r o n c h i a l + + + + + + + + + + + + + + + + + + + + + + + + + 4 4 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   1 L y m p h   n o d e ,   m a n d i b u l a r + + + + + + + + + + + + + + + + + + + + + + + + + 4 7 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   1 L y m p h   n o d e ,   m e s e n t e r i c + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L y m p h   n o d e ,   m e d i a s t i n a l M + M + + + + + + + + + + + + + + + + + + + + + + 4 0 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   2 S p l e e n + + + + + + + + + + + + + + + + + + + + + + + + + 4 8 T h y m u s + + + + + + + + + + + + + + + + + + + + + + + + + 4 5 I n t e g u m e n t a r y   S y s t e m M a m m a r y   G l a n d M + M + + M M M + + + M M + + + M M M + + M + + M 2 4 C a r c i n o m a X 1 F i b r o a d e n o m a X 1 S k i n + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 K e r a t o c a n t h o m a X X 2 S q u a m o u s   c e l l   p a p i l l o m a 1 S u b c u t a n e o u s   t i s s u e ,   f i b r o m a X 3 S u b c u t a n e o u s   t i s s u e ,   f i b r o s a r c m a 1 S u b c u t a n e o u s   t i s s u e ,   l i p o m a 1 M u s c u l o s k e l e t a l   S y s t e m B o n e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 O s t e o s a r c o m a 1 N e r v o u s   S y s t e m B r a i n + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 1 3 2 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 3   m g / m 3   ( S t o p - E x p o s u r e ) 5 5 5 5 5 5 5 6 6 6 6 6 6 6 6 6 6 6 6 6 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 2 3 3 4 4 6 6 0 2 5 5 5 7 7 7 7 7 8 8 9 0 2 2 3 3 5 0 2 5 7 0 0 3 1 6 8 8 1 2 2 6 6 4 6 5 6 8 8 0 3 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 C a r c a s s   I D   N u m b e r 2 4 2 1 0 0 2 4 4 2 3 5 3 3 3 0 1 0 3 1 4 2 4 1 0 9 3 0 6 4 8 5 5 9 8 3 0 0 1 7 1 9 6 9 2 1 6 6 7 3 R e s p i r a t o r y   S y s t e m         L a r y n x + + + + + + + + + + + + + + + + + + + + + + + + + L u n g + + + + + + + + + + + + + + + + + + + + + + + + + A l v e o l a r / b r o n c h i o l a r   a d e n o m a X X X X X X X A l v e o l a r / b r o n c h i o l a r   a d e n o m a ,   m u l t i p l e X X X X   A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a X X X X X X A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m u l t i p l e X             S q u a m o u s   c e l l   c a r c i n o m a X X X X N o s e + + + + + + + + + + + + + + + + + + + + + + + + + S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X P l e u r a + + A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X                 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X   T r a c h e a + + + + + + + + A + + + + + + + + + + + + + + + + S p e c i a l   S e n s e s   S y s t e m   E y e + Z y m b a l ’ s   g l a n d A d e n o m a U r i n a r y   S y s t e m                 K i d n e y + + + + + + + + + + + + + + + + + + + + + + + + + S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g X X U r i n a r y   b l a d d e r + + + + + + + + + + + + + + + + + + + + + + + + + T r a n s i t i o n a l   e p i t h e l i u m ,   p a p i l l o m a X S y s t e m i c   L e s i o n s             M u l t i p l e   o r g a n s + + + + + + + + + + + + + + + + + + + + + + + + + L e u k e m i a   m o n o n u c l e a r X X X X X X X X X X X I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 3 3 T A B L E   A 2 I n d i v i d u a l   A n i m a l   T u m o r   P a t h o l o g y   o f   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e :     0 . 3   m g / m 3   ( S t o p - E x p o s u r e ) 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 N u m b e r   o f   D a y s   o n   S t u d y 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 T o t a l C a r c a s s   I D   N u m b e r 0 1 1 1 1 1 1 2 2 3 3 4 0 0 2 3 3 4 4 4 4 0 2 2 3 T i s s u e s / 5 0 1 3 4 5 8 3 4 2 6 4 2 9 7 5 8 0 2 7 8 7 1 2 4 T u m o r s R e s p i r a t o r y   S y s t e m L a r y n x + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L u n g + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 A l v e o l a r / b r o n c h i o l a r   a d e n o m a X X X X X X X X X X X 1 8 A l v e o l a r / b r o n c h i o l a r   a d e n o m a ,   m u l t i p l e X X X X X X X X 1 2 A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a X X X X X 1 1 A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m u l t i p l e X X X X   5 S q u a m o u s   c e l l   c a r c i n o m a 4 N o s e + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   1 P l e u r a   2 A l v e o l a r / b r o n c h i o l a r   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g 1 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   1 T r a c h e a + + + + + + + + + + + + + + + + + + + + + + + + + 4 9 S p e c i a l   S e n s e s   S y s t e m E y e   1 Z y m b a l ’ s   g l a n d +   1 A d e n o m a X   1 U r i n a r y   S y s t e m K i d n e y + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 S q u a m o u s   c e l l   c a r c i n o m a ,   m e t a s t a t i c ,   l u n g   2 U r i n a r y   b l a d d e r + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 T r a n s i t i o n a l   e p i t h e l i u m ,   p a p i l l o m a   1 S y s t e m i c   L e s i o n s         M u l t i p l e   o r g a n s + + + + + + + + + + + + + + + + + + + + + + + + + 5 0 L e u k e m i a   m o n o n u c l e a r X X X X X X X X X X X X X X 2 5 1 3 4   I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 3 S t a t i s t i c a l   A n a l y s i s   o f   P r i m a r y   N e o p l a s m s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) A d r e n a l   M e d u l l a :     B e n i g n   P h e o c h r o m o c y t o m a O v e r a l l   r a t e a 1 0 / 5 0   ( 2 0 % ) 2 2 / 5 0   ( 4 4 % ) 1 6 / 4 9   ( 3 3 % ) 2 3 / 5 0   ( 4 6 % ) A d j u s t e d   r a t e b 2 3 . 8 % 4 8 . 8 % 3 8 . 0 % 5 1 . 1 % T e r m i n a l   r a t e c 6 / 2 7   ( 2 2 % ) 1 7 / 2 9   ( 5 9 % ) 1 1 / 2 8   ( 3 9 % ) 1 5 / 2 6   ( 5 8 % ) F i r s t   i n c i d e n c e   ( d a y s ) 5 3 7 6 3 5 5 3 7 5 2 5 P o l y - 3   t e s t d P = 0 . 0 0 6 P = 0 . 0 1 1 P = 0 . 1 1 7 P = 0 . 0 0 6 A d r e n a l   M e d u l l a :     M a l i g n a n t   P h e o c h r o m o c y t o m a O v e r a l l   r a t e 0 / 5 0   ( 0 % ) 3 / 5 0   ( 6 % ) 3 / 4 9   ( 6 % ) 1 / 5 0   ( 2 % ) A d j u s t e d   r a t e 0 . 0 % 6 . 8 % 7 . 4 % 2 . 3 % T e r m i n a l   r a t e 0 / 2 7   ( 0 % ) 2 / 2 9   ( 7 % ) 2 / 2 8   ( 7 % ) 0 / 2 6   ( 0 % ) F i r s t   i n c i d e n c e   ( d a y s ) — e 6 2 8 6 9 8 6 8 4 P o l y - 3   t e s t P = 0 . 5 8 6 P = 0 . 1 3 6 P = 0 . 1 1 9 P = 0 . 5 1 1   A d r e n a l   M e d u l l a :     B e n i g n ,   C o m p l e x ,   o r   M a l i g n a n t   P h e o c h r o m o c y t o m a O v e r a l l   r a t e 1 0 / 5 0   ( 2 0 % ) 2 6 / 5 0   ( 5 2 % ) 1 8 / 4 9   ( 3 7 % ) 2 4 / 5 0   ( 4 8 % ) A d j u s t e d   r a t e 2 3 . 8 % 5 7 . 1 % 4 2 . 6 % 5 3 . 1 % T e r m i n a l   r a t e 6 / 2 7   ( 2 2 % ) 1 9 / 2 9   ( 6 6 % ) 1 2 / 2 8   ( 4 3 % ) 1 5 / 2 6   ( 5 8 % ) F i r s t   i n c i d e n c e   ( d a y s ) 5 3 7 6 2 8 5 3 7 5 2 5 P o l y - 3   t e s t P = 0 . 0 0 5 P < 0 . 0 0 1 P = 0 . 0 5 1 P = 0 . 0 0 3 B o n e :     O s t e o s a r c o m a O v e r a l l   r a t e 3 / 5 0   ( 6 % ) 0 / 5 0   ( 0 % ) 1 / 5 0   ( 2 % ) 1 / 5 0   ( 2 % ) A d j u s t e d   r a t e 7 . 2 % 0 . 0 % 2 . 4 % 2 . 3 % T e r m i n a l   r a t e 0 / 2 7   ( 0 % ) 0 / 2 9   ( 0 % ) 0 / 2 9   ( 0 % ) 0 / 2 6   ( 0 % ) F i r s t   i n c i d e n c e   ( d a y s ) 4 0 8 — 4 3 5 6 7 1 P o l y - 3   t e s t P = 0 . 2 6 8 N P = 0 . 1 1 0 N P = 0 . 3 0 2 N P = 0 . 2 9 8 N B o n e :     O s t e o m a   o r   O s t e o s a r c o m a O v e r a l l   r a t e 3 / 5 0   ( 6 % ) 0 / 5 0   ( 0 % ) 2 / 5 0   ( 4 % ) 1 / 5 0   ( 2 % ) A d j u s t e d   r a t e 7 . 2 % 0 . 0 % 4 . 7 % 2 . 3 % T e r m i n a l   r a t e 0 / 2 7   ( 0 % ) 0 / 2 9   ( 0 % ) 0 / 2 9   ( 0 % ) 0 / 2 6   ( 0 % ) F i r s t   i n c i d e n c e   ( d a y s ) 4 0 8 — 4 3 5 6 7 1 P o l y - 3   t e s t P = 0 . 2 4 8 N P = 0 . 1 1 0 N P = 0 . 4 9 4 N P = 0 . 2 9 8 N L u n g :     A l v e o l a r / b r o n c h i o l a r   A d e n o m a O v e r a l l   r a t e 6 / 5 0   ( 1 2 % ) 1 3 / 5 0   ( 2 6 % ) 2 7 / 5 0   ( 5 4 % ) 3 0 / 5 0   ( 6 0 % ) A d j u s t e d   r a t e 1 4 . 8 % 2 9 . 1 % 6 2 . 9 % 6 7 . 0 % T e r m i n a l   r a t e 4 / 2 7   ( 1 5 % ) 8 / 2 9   ( 2 8 % ) 2 1 / 2 9   ( 7 2 % ) 2 0 / 2 6   ( 7 7 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 9 7 6 8 5 6 4 4 5 2 5 P o l y - 3   t e s t P < 0 . 0 0 1 P = 0 . 0 9 0 P < 0 . 0 0 1 P < 0 . 0 0 1 L u n g :     A l v e o l a r / b r o n c h i o l a r   C a r c i n o m a O v e r a l l   r a t e 1 / 5 0   ( 2 % ) 1 0 / 5 0   ( 2 0 % ) 8 / 5 0   ( 1 6 % ) 1 6 / 5 0   ( 3 2 % ) A d j u s t e d   r a t e 2 . 5 % 2 2 . 4 % 1 9 . 3 % 3 6 . 5 % T e r m i n a l   r a t e 0 / 2 7   ( 0 % ) 6 / 2 9   ( 2 1 % ) 7 / 2 9   ( 2 4 % ) 9 / 2 6   ( 3 5 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 3 9 6 3 5 7 1 0 6 2 1 P o l y - 3   t e s t P < 0 . 0 0 1 P = 0 . 0 0 6 P = 0 . 0 1 6 P < 0 . 0 0 1 I n d i u m   P h o s p h i d e   N T P   T R   4 9 9 1 3 5 T A B L E   A 3 S t a t i s t i c a l   A n a l y s i s   o f   P r i m a r y   N e o p l a s m s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) L u n g :     A l v e o l a r / b r o n c h i o l a r   A d e n o m a   o r   C a r c i n o m a   O v e r a l l   r a t e 7 / 5 0   ( 1 4 % ) 2 2 / 5 0   ( 4 4 % ) 3 0 / 5 0   ( 6 0 % ) 3 5 / 5 0   ( 7 0 % ) A d j u s t e d   r a t e 1 7 . 1 % 4 8 . 7 % 6 9 . 8 % 7 6 . 1 % T e r m i n a l   r a t e 4 / 2 7   ( 1 5 % ) 1 4 / 2 9   ( 4 8 % ) 2 4 / 2 9   ( 8 3 % ) 2 1 / 2 6   ( 8 1 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 3 9 6 3 5 6 4 4 5 2 5 P o l y - 3   t e s t P < 0 . 0 0 1 P < 0 . 0 0 1 P < 0 . 0 0 1 P < 0 . 0 0 1 L u n g :     S q u a m o u s   C e l l   C a r c i n o m a O v e r a l l   r a t e 0 / 5 0   ( 0 % ) 0 / 5 0   ( 0 % ) 0 / 5 0   ( 0 % ) 4 / 5 0   ( 8 % ) A d j u s t e d   r a t e 0 . 0 % 0 . 0 % 0 . 0 % 9 . 1 % T e r m i n a l   r a t e 0 / 2 7   ( 0 % ) 0 / 2 9   ( 0 % ) 0 / 2 9   ( 0 % ) 0 / 2 6   ( 0 % ) F i r s t   i n c i d e n c e   ( d a y s ) — — — 5 4 5 P o l y - 3   t e s t P = 0 . 0 1 1 — f — P = 0 . 0 7 1   O r a l   M u c o s a   ( P h a r y n x ,   G i n g i v a ) :     S q u a m o u s   P a p i l l o m a O v e r a l l   r a t e 1 / 5 0   ( 2 % ) 0 / 5 0   ( 0 % ) 3 / 5 0   ( 6 % ) 1 / 5 0   ( 2 % ) A d j u s t e d   r a t e 2 . 5 % 0 . 0 % 7 . 2 % 2 . 4 % T e r m i n a l   r a t e 1 / 2 7   ( 4 % ) 0 / 2 9   ( 0 % ) 2 / 2 9   ( 7 % ) 1 / 2 6   ( 4 % ) F i r s t   i n c i d e n c e   ( d a y s ) 7 3 3   ( T ) — 6 9 8 7 3 3   ( T ) P o l y - 3   t e s t P = 0 . 5 2 6 N P = 0 . 4 8 3 N P = 0 . 3 1 5 P = 0 . 7 5 0 N P a n c r e a t i c   I s l e t s :     A d e n o m a O v e r a l l   r a t e 1 / 5 0   ( 2 % ) 2 / 5 0   ( 4 % ) 2 / 5 0   ( 4 % ) 3 / 5 0   ( 6 % ) A d j u s t e d   r a t e 2 . 5 % 4 . 5 % 4 . 8 % 7 . 0 % T e r m i n a l   r a t e 1 / 2 7   ( 4 % ) 1 / 2 9   ( 3 % ) 2 / 2 9   ( 7 % ) 2 / 2 6   ( 8 % ) F i r s t   i n c i d e n c e   ( d a y s ) 7 3 3   ( T ) 7 0 1 7 3 3   ( T ) 6 5 8 P o l y - 3   t e s t P = 0 . 2 7 3 P = 0 . 5 3 1 P = 0 . 5 0 9 P = 0 . 3 2 5   P a n c r e a t i c   I s l e t s :     C a r c i n o m a O v e r a l l   r a t e 2 / 5 0   ( 4 % ) 0 / 5 0   ( 0 % ) 4 / 5 0   ( 8 % ) 3 / 5 0   ( 6 % ) A d j u s t e d   r a t e 4 . 9 % 0 . 0 % 9 . 5 % 7 . 0 % T e r m i n a l   r a t e 0 / 2 7   ( 0 % ) 0 / 2 9   ( 0 % ) 2 / 2 9   ( 7 % ) 1 / 2 6   ( 4 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 1 7 — 6 4 9 6 8 4 P o l y - 3   t e s t P = 0 . 5 2 6 P = 0 . 2 2 1 N P = 0 . 3 4 9 P = 0 . 5 1 9   P a n c r e a t i c   I s l e t s :     A d e n o m a   o r   C a r c i n o m a O v e r a l l   r a t e 3 / 5 0   ( 6 % ) 2 / 5 0   ( 4 % ) 6 / 5 0   ( 1 2 % ) 6 / 5 0   ( 1 2 % ) A d j u s t e d   r a t e 7 . 3 % 4 . 5 % 1 4 . 3 % 1 4 . 0 % T e r m i n a l   r a t e 1 / 2 7   ( 4 % ) 1 / 2 9   ( 3 % ) 4 / 2 9   ( 1 4 % ) 3 / 2 6   ( 1 2 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 1 7 7 0 1 6 4 9 6 5 8 P o l y - 3   t e s t P = 0 . 2 8 5 P = 0 . 4 6 5 N P = 0 . 2 5 3 P = 0 . 2 6 5   P i t u i t a r y   G l a n d   ( P a r s   D i s t a l i s ) :     A d e n o m a O v e r a l l   r a t e 3 6 / 4 9   ( 7 3 % ) 3 3 / 5 0   ( 6 6 % ) 3 1 / 5 0   ( 6 2 % ) 3 0 / 5 0   ( 6 0 % ) A d j u s t e d   r a t e 7 9 . 6 % 6 9 . 2 % 6 7 . 6 % 6 4 . 0 % T e r m i n a l   r a t e 2 1 / 2 7   ( 7 8 % ) 2 0 / 2 9   ( 6 9 % ) 1 9 / 2 9   ( 6 6 % ) 1 6 / 2 6   ( 6 2 % ) F i r s t   i n c i d e n c e   ( d a y s ) 4 9 5 5 2 6 4 3 5 5 2 5 P o l y - 3   t e s t P = 0 . 0 7 8 N P = 0 . 1 7 5 N P = 0 . 1 3 5 N P = 0 . 0 6 7 N 1 3 6   I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 3 S t a t i s t i c a l   A n a l y s i s   o f   P r i m a r y   N e o p l a s m s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) P i t u i t a r y   G l a n d   ( P a r s   D i s t a l i s ) :     A d e n o m a   o r   C a r c i n o m a O v e r a l l   r a t e 3 7 / 4 9   ( 7 6 % ) 3 4 / 5 0   ( 6 8 % ) 3 1 / 5 0   ( 6 2 % ) 3 0 / 5 0   ( 6 0 % ) A d j u s t e d   r a t e 8 1 . 8 % 7 1 . 2 % 6 7 . 6 % 6 4 . 0 % T e r m i n a l   r a t e 2 2 / 2 7   ( 8 2 % ) 2 0 / 2 9   ( 6 9 % ) 1 9 / 2 9   ( 6 6 % ) 1 6 / 2 6   ( 6 2 % ) F i r s t   i n c i d e n c e   ( d a y s ) 4 9 5 5 2 6 4 3 5 5 2 5 P o l y - 3   t e s t P = 0 . 0 4 9 N P = 0 . 1 6 1 N P = 0 . 0 8 3 N P = 0 . 0 3 8 N P r e p u t i a l   G l a n d :     A d e n o m a   o r   C a r c i n o m a O v e r a l l   r a t e 3 / 5 0   ( 6 % ) 2 / 5 0   ( 4 % ) 1 / 5 0   ( 2 % ) 0 / 5 0   ( 0 % ) A d j u s t e d   r a t e 7 . 3 % 4 . 5 % 2 . 4 % 0 . 0 % T e r m i n a l   r a t e 1 / 2 7   ( 4 % ) 2 / 2 9   ( 7 % ) 1 / 2 9   ( 3 % ) 0 / 2 6   ( 0 % ) F i r s t   i n c i d e n c e   ( d a y s ) 5 3 7 7 3 3   ( T ) 7 3 3   ( T ) — P o l y - 3   t e s t P = 0 . 0 8 4 N P = 0 . 4 7 1 N P = 0 . 3 0 4 N P = 0 . 1 1 3 N S k i n :     K e r a t o a c a n t h o m a O v e r a l l   r a t e 2 / 5 0   ( 4 % ) 4 / 5 0   ( 8 % ) 5 / 5 0   ( 1 0 % ) 2 / 5 0   ( 4 % ) A d j u s t e d   r a t e 5 . 0 % 9 . 0 % 1 2 . 1 % 4 . 7 % T e r m i n a l   r a t e 2 / 2 7   ( 7 % ) 3 / 2 9   ( 1 0 % ) 5 / 2 9   ( 1 7 % ) 2 / 2 6   ( 8 % ) F i r s t   i n c i d e n c e   ( d a y s ) 7 3 3   ( T ) 5 7 6 7 3 3   ( T ) 7 3 3   ( T ) P o l y - 3   t e s t P = 0 . 4 7 0 N P = 0 . 3 8 3 P = 0 . 2 2 5 P = 0 . 6 7 7 N S k i n :     S q u a m o u s   C e l l   P a p i l l o m a   o r   K e r a t o a c a n t h o m a O v e r a l l   r a t e 2 / 5 0   ( 4 % ) 4 / 5 0   ( 8 % ) 5 / 5 0   ( 1 0 % ) 3 / 5 0   ( 6 % ) A d j u s t e d   r a t e 5 . 0 % 9 . 0 % 1 2 . 1 % 7 . 0 % T e r m i n a l   r a t e 2 / 2 7   ( 7 % ) 3 / 2 9   ( 1 0 % ) 5 / 2 9   ( 1 7 % ) 2 / 2 6   ( 8 % ) F i r s t   i n c i d e n c e   ( d a y s ) 7 3 3   ( T ) 5 7 6 7 3 3   ( T ) 5 6 0 P o l y - 3   t e s t P = 0 . 5 7 8 P = 0 . 3 8 3 P = 0 . 2 2 5 P = 0 . 5 2 8   S k i n :     S q u a m o u s   C e l l   P a p i l l o m a ,   K e r a t o a c a n t h o m a ,   o r   T r i c h o e p i t h e l i o m a O v e r a l l   r a t e 2 / 5 0   ( 4 % ) 4 / 5 0   ( 8 % ) 6 / 5 0   ( 1 2 % ) 3 / 5 0   ( 6 % ) A d j u s t e d   r a t e 5 . 0 % 9 . 0 % 1 4 . 5 % 7 . 0 % T e r m i n a l   r a t e 2 / 2 7   ( 7 % ) 3 / 2 9   ( 1 0 % ) 6 / 2 9   ( 2 1 % ) 2 / 2 6   ( 8 % ) F i r s t   i n c i d e n c e   ( d a y s ) 7 3 3   ( T ) 5 7 6 7 3 3   ( T ) 5 6 0 P o l y - 3   t e s t P = 0 . 5 9 1 N P = 0 . 3 8 3 P = 0 . 1 3 9 P = 0 . 5 2 8   S k i n   ( S u b c u t a n e o u s   T i s s u e ) :     F i b r o m a O v e r a l l   r a t e 1 / 5 0   ( 2 % ) 4 / 5 0   ( 8 % ) 7 / 5 0   ( 1 4 % ) 3 / 5 0   ( 6 % ) A d j u s t e d   r a t e 2 . 5 % 9 . 0 % 1 6 . 8 % 7 . 0 % T e r m i n a l   r a t e 0 / 2 7   ( 0 % ) 2 / 2 9   ( 7 % ) 6 / 2 9   ( 2 1 % ) 1 / 2 6   ( 4 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 7 2 6 8 6 6 6 5 6 7 2 P o l y - 3   t e s t P = 0 . 5 0 8 P = 0 . 2 0 6 P = 0 . 0 3 2 P = 0 . 3 2 3   S k i n   ( S u b c u t a n e o u s   T i s s u e ) :     F i b r o m a   o r   F i b r o s a r c o m a O v e r a l l   r a t e 2 / 5 0   ( 4 % ) 4 / 5 0   ( 8 % ) 8 / 5 0   ( 1 6 % ) 4 / 5 0   ( 8 % ) A d j u s t e d   r a t e 4 . 9 % 9 . 0 % 1 9 . 2 % 9 . 3 % T e r m i n a l   r a t e 1 / 2 7   ( 4 % ) 2 / 2 9   ( 7 % ) 7 / 2 9   ( 2 4 % ) 1 / 2 6   ( 4 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 7 2 6 8 6 6 6 5 6 7 1 P o l y - 3   t e s t P = 0 . 5 1 9 P = 0 . 3 7 8 P = 0 . 0 4 7 P = 0 . 3 6 2   I n d i u m   P h o s p h i d e   N T P   T R   4 9 9 1 3 7 T A B L E   A 3 S t a t i s t i c a l   A n a l y s i s   o f   P r i m a r y   N e o p l a s m s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) T e s t e s :     A d e n o m a O v e r a l l   r a t e 4 0 / 5 0   ( 8 0 % ) 3 5 / 5 0   ( 7 0 % ) 4 1 / 5 0   ( 8 2 % ) 3 3 / 5 0   ( 6 6 % ) A d j u s t e d   r a t e 8 6 . 1 % 7 6 . 4 % 9 1 . 3 % 7 3 . 9 % T e r m i n a l   r a t e 2 4 / 2 7   ( 8 9 % ) 2 6 / 2 9   ( 9 0 % ) 2 9 / 2 9   ( 1 0 0 % ) 2 3 / 2 6   ( 8 9 % ) F i r s t   i n c i d e n c e   ( d a y s ) 4 0 8 5 8 6 5 5 2 5 3 2 P o l y - 3   t e s t P = 0 . 0 2 9 N P = 0 . 1 5 7 N P = 0 . 3 0 1 P = 0 . 0 9 2 N T h y r o i d   G l a n d   ( C - c e l l ) :     A d e n o m a O v e r a l l   r a t e 5 / 4 9   ( 1 0 % ) 8 / 4 9   ( 1 6 % ) 4 / 4 8   ( 8 % ) 9 / 4 8   ( 1 9 % ) A d j u s t e d   r a t e 1 2 . 6 % 1 8 . 3 % 9 . 9 % 2 1 . 5 % T e r m i n a l   r a t e 4 / 2 7   ( 1 5 % ) 6 / 2 8   ( 2 1 % ) 4 / 2 9   ( 1 4 % ) 6 / 2 6   ( 2 3 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 9 7 6 3 5 7 3 3   ( T ) 5 2 5 P o l y - 3   t e s t P = 0 . 1 2 6 P = 0 . 3 3 6 P = 0 . 4 8 9 N P = 0 . 2 1 8   T h y r o i d   G l a n d   ( C - c e l l ) :     C a r c i n o m a O v e r a l l   r a t e 1 / 4 9   ( 2 % ) 4 / 4 9   ( 8 % ) 3 / 4 8   ( 6 % ) 1 / 4 8   ( 2 % ) A d j u s t e d   r a t e 2 . 5 % 9 . 3 % 7 . 4 % 2 . 5 % T e r m i n a l   r a t e 0 / 2 7   ( 0 % ) 3 / 2 8   ( 1 1 % ) 3 / 2 9   ( 1 0 % ) 1 / 2 6   ( 4 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 7 2 7 0 2 7 3 3   ( T ) 7 3 3   ( T ) P o l y - 3   t e s t P = 0 . 5 3 6 N P = 0 . 2 0 2 P = 0 . 3 1 0 P = 0 . 7 5 6 N T h y r o i d   G l a n d   ( C - c e l l ) :     A d e n o m a   o r   C a r c i n o m a O v e r a l l   r a t e 6 / 4 9   ( 1 2 % ) 1 1 / 4 9   ( 2 2 % ) 7 / 4 8   ( 1 5 % ) 1 0 / 4 8   ( 2 1 % ) A d j u s t e d   r a t e 1 5 . 0 % 2 5 . 1 % 1 7 . 3 % 2 3 . 9 % T e r m i n a l   r a t e 4 / 2 7   ( 1 5 % ) 8 / 2 8   ( 2 9 % ) 7 / 2 9   ( 2 4 % ) 7 / 2 6   ( 2 7 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 7 2 6 3 5 7 3 3   ( T ) 5 2 5 P o l y - 3   t e s t P = 0 . 1 8 8 P = 0 . 1 8 8 P = 0 . 5 0 9 P = 0 . 2 3 0   A l l   O r g a n s :     H i s t i o c y t i c   S a r c o m a O v e r a l l   r a t e 0 / 5 0   ( 0 % ) 3 / 5 0   ( 6 % ) 0 / 5 0   ( 0 % ) 0 / 5 0   ( 0 % ) A d j u s t e d   r a t e 0 . 0 % 6 . 6 % 0 . 0 % 0 . 0 % T e r m i n a l   r a t e 0 / 2 7   ( 0 % ) 0 / 2 9   ( 0 % ) 0 / 2 9   ( 0 % ) 0 / 2 6   ( 0 % ) F i r s t   i n c i d e n c e   ( d a y s ) — 2 8 5 — — P o l y - 3   t e s t — P = 0 . 1 4 1 — — A l l   O r g a n s :     M o n o n u c l e a r   C e l l   L e u k e m i a O v e r a l l   r a t e 1 6 / 5 0   ( 3 2 % ) 2 3 / 5 0   ( 4 6 % ) 2 9 / 5 0   ( 5 8 % ) 2 5 / 5 0   ( 5 0 % ) A d j u s t e d   r a t e 3 7 . 0 % 4 9 . 6 % 6 1 . 6 % 5 5 . 8 % T e r m i n a l   r a t e 9 / 2 7   ( 3 3 % ) 1 4 / 2 9   ( 4 8 % ) 1 4 / 2 9   ( 4 8 % ) 1 4 / 2 6   ( 5 4 % ) F i r s t   i n c i d e n c e   ( d a y s ) 1 3 5 5 8 6 4 0 3 5 3 2 P o l y - 3   t e s t P = 0 . 1 0 4 P = 0 . 1 5 7 P = 0 . 0 1 3 P = 0 . 0 5 3   A l l   O r g a n s :     B e n i g n   N e o p l a s m s O v e r a l l   r a t e 4 7 / 5 0   ( 9 4 % ) 4 8 / 5 0   ( 9 6 % ) 4 8 / 5 0   ( 9 6 % ) 4 8 / 5 0   ( 9 6 % ) A d j u s t e d   r a t e 9 7 . 0 % 9 7 . 9 % 9 9 . 1 % 9 8 . 0 % T e r m i n a l   r a t e 2 6 / 2 7   ( 9 6 % ) 2 9 / 2 9   ( 1 0 0 % ) 2 9 / 2 9   ( 1 0 0 % ) 2 6 / 2 6   ( 1 0 0 % ) F i r s t   i n c i d e n c e   ( d a y s ) 4 0 8 5 2 6 4 3 5 5 2 5 P o l y - 3   t e s t P = 0 . 6 3 2 P = 0 . 6 5 4 P = 0 . 4 9 4 P = 0 . 6 5 7   1 3 8   I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   A 3 S t a t i s t i c a l   A n a l y s i s   o f   P r i m a r y   N e o p l a s m s   i n   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) A l l   O r g a n s :     M a l i g n a n t   N e o p l a s m s O v e r a l l   r a t e 2 6 / 5 0   ( 5 2 % ) 3 7 / 5 0   ( 7 4 % ) 4 2 / 5 0   ( 8 4 % ) 3 7 / 5 0   ( 7 4 % ) A d j u s t e d   r a t e 5 6 . 0 % 7 6 . 6 % 8 5 . 6 % 7 8 . 5 % T e r m i n a l   r a t e 1 1 / 2 7   ( 4 1 % ) 1 9 / 2 9   ( 6 6 % ) 2 3 / 2 9   ( 7 9 % ) 1 9 / 2 6   ( 7 3 % ) F i r s t   i n c i d e n c e   ( d a y s ) 1 3 5 2 8 5 4 0 3 5 3 2 P o l y - 3   t e s t P = 0 . 0 3 0 P = 0 . 0 2 4 P < 0 . 0 0 1 P = 0 . 0 1 4 A l l   O r g a n s :     B e n i g n   o r   M a l i g n a n t   N e o p l a s m s O v e r a l l   r a t e 4 9 / 5 0   ( 9 8 % ) 5 0 / 5 0   ( 1 0 0 % ) 5 0 / 5 0   ( 1 0 0 % ) 5 0 / 5 0   ( 1 0 0 % ) A d j u s t e d   r a t e 9 9 . 1 % 1 0 0 . 0 % 1 0 0 . 0 % 1 0 0 . 0 % T e r m i n a l   r a t e 2 7 / 2 7   ( 1 0 0 % ) 2 9 / 2 9   ( 1 0 0 % ) 2 9 / 2 9   ( 1 0 0 % ) 2 6 / 2 6   ( 1 0 0 % ) F i r s t   i n c i d e n c e   ( d a y s ) 1 3 5 2 8 5 4 0 3 5 2 5 P o l y - 3   t e s t P = 0 . 7 9 5 P = 0 . 9 1 0 P = 0 . 9 1 0 P = 0 . 9 1 0   ( T ) T e r m i n a l   s a c r i f i c e a N u m b e r   o f   n e o p l a s m - b e a r i n g   a n i m a l s / n u m b e r   o f   a n i m a l s   e x a m i n e d .     D e n o m i n a t o r   i s   n u m b e r   o f   a n i m a l s   e x a m i n e d   m i c r o s c o p i c a l l y   f o r   a d r e n a l   g l a n d ,   l u n g ,   p a n c r e a t i c   i s l e t s ,   p i t u i t a r y   g l a n d ,   p r e p u t i a l   g l a n d ,   t e s t i s ,   a n d   t h y r o i d   g l a n d ;   f o r   o t h e r   t i s s u e s ,   d e n o m i n a t o r   i s   n u m b e r   o f   a n i m a l s   n e c r o p s i e d . b P o l y - 3   e s t i m a t e d   n e o p l a s m   i n c i d e n c e   a f t e r   a d j u s t m e n t   f o r   i n t e r c u r r e n t   m o r t a l i t y c O b s e r v e d   i n c i d e n c e   a t   t e r m i n a l   k i l l d B e n e a t h   t h e   c h a m b e r   c o n t r o l   i n c i d e n c e   a r e   t h e   P   v a l u e s   a s s o c i a t e d   w i t h   t h e   t r e n d   t e s t   ( t h e   0 . 0 3   m g / m 3   g r o u p   w a s   e x c l u d e d   f r o m   t h e   t r e n d   t e s t ) .     B e n e a t h   t h e e x p o s e d   g r o u p   i n c i d e n c e   a r e   t h e   P   v a l u e s   c o r r e s p o n d i n g   t o   p a i r w i s e   c o m p a r i s o n s   b e t w e e n   t h e   c h a m b e r   c o n t r o l s   a n d   t h a t   e x p o s e d   g r o u p .     T h e   P o l y - 3   t e s t a c c o u n t s   f o r   d i f f e r e n t i a l   m o r t a l i t y   i n   a n i m a l s   t h a t   d o   n o t   r e a c h   t e r m i n a l   s a c r i f i c e .     A   n e g a t i v e   t r e n d   o r   a   l o w e r   i n c i d e n c e   i n   a n   e x p o s u r e   g r o u p   i s   i n d i c a t e d   b y   N . e N o t   a p p l i c a b l e ;   n o   n e o p l a s m s   i n   a n i m a l   g r o u p f V a l u e   o f   s t a t i s t i c   c a n n o t   b e   c o m p u t e d . I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 1 3 9 T A B L E   A 4 a H i s t o r i c a l   I n c i d e n c e   o f   L u n g   N e o p l a s m s   i n   C o n t r o l   M a l e   F 3 4 4 / N   R a t s I n c i d e n c e   i n   C o n t r o l s S t u d y A l v e o l a r / b r o n c h i o l a r   A l v e o l a r / b r o n c h i o l a r   A l v e o l a r / b r o n c h i o l a r S q u a m o u s   C e l l A d e n o m a C a r c i n o m a   A d e n o m a   o r   C a r c i n o m a C a r c i n o m a H i s t o r i c a l   I n c i d e n c e   i n   C o n t r o l s   G i v e n   N T P - 2 0 0 0   F e e d a p , p N - D i c h l o r o