0.34
                                    0.0027
                                    0.00057
                                    38,000
                                    180,000

Leafy Greens, Succulent-Podded and Succulent-Shelled Beans, Tuberous and Corm Vegetables, and Fruiting Vegetables
                                     0.16
                                      80
                                     acres
                                     78.6
                                     16.1
                                     0.34
                                    0.0055
                                    0.0012
                                    18,000
                                    86,000

                        Fruiting Vegetables Soil Drench
                                     0.047
                                      80
                                     acres
                                     78.6
                                     16.1
                                     0.34
                                    0.0016
                                    0.00034
                                    62,000
                                    290,000
                                    Flagger
                          Flagging for Aerial Sprays
Leafy Greens, Succulent-Podded and Succulent-Shelled Beans, Tuberous and Corm Vegetables, and Fruiting Vegetables
                                     0.072
                                      350
                                     acres
                                      11
                                      12
                                     0.35
                                    0.0016
                                    0.0018
                                    62,000
                                    57,000

                                     Basil
                                     0.078
                                      350
                                     acres
                                      11
                                      12
                                     0.35
                                    0.0018
                                    0.0019
                                    57,000
                                    53,000
                            Mixer/Loader/Applicator
                         Manually Pressurized Handwand
                   Tomato Greenhouse Transplant Soil Drench
                                    0.0085
                                      40
                                    gallons
                                    100,000
                                      430
                                      30
                                     0.21
                                    0.0011
                                      480
                                    93,000
                               Backpack Sprayer
                   Tomato Greenhouse Transplant Soil Drench
                                    0.0085
                                      40
                                    gallons
                                     8,260
                                     8,260
                                     2.58
                                     0.017
                                     0.017
                                     5,800
                                     5,800
                       Mechanically Pressurized Handgun
                   Tomato Greenhouse Transplant Soil Drench
                                    0.0085
                                      625
                                    gallons
                                     4,310
                                     4,310
                                     3,931
                                     0.49
                                     0.49
                                      200
                                      200
a	Application Rates based on proposed uses for cyazofamid (Ranman(R) 400SC, EPA Reg. No. 71512-3).
b	Amount Treated Daily taken from Exposure Science Advisory Council (ExpoSAC) Policy No. 9.1.
c	UEs = Unit Exposures based on PHED Version 1.1.  Level of mitigation = Baseline (no gloves, no respirator) or PPE (gloves, no respirator).
d	Dose (mg/kg/day) = daily unit exposure (μg/lb ai) x application rate (lb ai/acre or gal) x area treated or amount handled/day (acres/day or gal/day) x conversion factor (1 mg/1,000 μg) x absorption factor (%) / body weight (69 kg). Dermal absorption factor = 37%. No inhalation absorption factor.
e	Combined Dose = Dermal Dose (mg/kg/day) + Inhalation Dose (mg/kg/day).
f	Combined MOE = NOAEL / Combined Dose (mg/kg/day). ST/IT Dermal/Inhalation NOAEL = 100 mg/kg/day. ST/IT level of concern = 100.

Table D-2.  Post-Application Exposure and Risk Estimates for Cyazofamid on Day of Application (Day 0)
                                     Crop
                           Proposed Application Rate
                                   Activity
                            Transfer Coefficient a
                         Chemical-Specific DFR Data b
                               Normalized DFR c
                             Daily Dermal Dose [d]
                      Short- and Intermediate- Term MOE e

                                    lb ai/A

                                   cm[2]/hr

                                   μg/cm[2]
                                   mg/kg/day

                                 Leafy Greens
                                     0.072
                             Irrigation (hand set)
                                     1900
                                  Squash DFR
                                     0.061
                                    0.0049
                                    20,000

                 Irrigation (non-hand set), Mechanical Weeding
                                       0

                                     0.061
                                      N/A
                                      N/A

                                   Scouting
                                      210

                                     0.061
                                    0.00055
                                    180,000

                                Hand Harvesting
                                     1100

                                     0.061
                                    0.0029
                                    35,000

                         Thinning plants, Hand Weeding
                                      70

                                     0.061
                                   0.000018
                                    550,000

                                 Transplanting
                                      230

                                     0.061
                                    0.00060
                                    170,000
                 Succulent-Podded and Succulent-Shelled Beans
                          Beans, Snap and Pea, Green
                                     0.072
                             Irrigation (hand set)
                                     1900
                                   Grape DFR
                                     0.129
                                    0.0105
                                     9,500

Irrigation (non-hand set), Mechanical Harvesting, Mechanical Weeding, Fertilizing
                                       0

                                     0.129
                                      N/A
                                      N/A

                                   Scouting
                                      210

                                     0.129
                                    0.0012
                                    86,000

                                 Hand weeding
                                      70

                                     0.129
                                    0.00039
                                    260,000

                                Hand Harvesting
                                     1100

                                     0.129
                                    0.0061
                                    16,000
                         Tuberous and Corm Vegetables
                                    Potato
                                     0.16
                             Irrigation (hand set)
                                     1900
                                  Squash DFR
                                     0.027
                                    0.0022
                                    45,000

     Irrigation (non-hand set), Mechanical Weeding, Mechanical Harvesting
                                       0

                                     0.027
                                      N/A
                                      N/A

                                   Scouting
                                      210

                                     0.027
                                    0.00025
                                    400,000

                                 Hand Weeding
                                      70

                                     0.027
                                   0.000082
                                   1,200,000

                                Hand Harvesting
                            Alternate Guidance [f]

                                     0.027
                                See Footnote f
                              Fruiting Vegetables
                                   Eggplant
                                     0.072
                                Hand Harvesting
                                      550
                                  Tomato DFR
                                     0.069
                                    0.0016
                                    61,000

                                Tying/Training
                                      550

                                     0.069
                                    0.0016
                                    61,000

             Scouting, Hand Weeding, Hand Pruning, Fruit Thinning
                                      90

                                     0.069
                                    0.00027
                                    380,000
               Eggplant, Okra, Bell Pepper, Chili Pepper, Tomato
                                     0.072
                             Irrigation, Hand Set
                                     1900

                                     0.069
                                    0.0056
                                    18,000

     Irrigation (Non Hand Set), Mechanical Weeding, Mechanical Harvesting
                                       0

                                     0.069
                                      N/A
                                      N/A
                            Eggplant, Okra, Tomato

                                 Transplanting
                                      230

                                     0.069
                                    0.00068
                                    150,000
                    Okra, Bell Pepper, Chili Pepper, Tomato

                     Hand Harvesting and/or Tying/Training
                                     1100

                                     0.069
                                    0.0033
                                    31,000

                                   Scouting
                                      210

                                     0.069
                                    0.00062
                                    160,000

                                 Hand Weeding
                                      70

                                     0.069
                                    0.00021
                                    480,000
                             Chili Pepper, Tomato

                                 Hand Pruning
                                      70

                                     0.069
                                    0.00021
                                    480,000
                           Basil (Mint as surrogate)
                           Basil (Mint as surrogate)
                                     0.078
                             Irrigation (hand set)
                                     1900
                                  Squash DFR
                                     0.056
                                    0.0046
                                    22,000

        Irrigation (non-hand set), Mechanical Harvesting, Transplating
                                       0

                                     0.056
                                      N/A
                                      N/A

                                   Scouting
                                     1100

                                     0.056
                                    0.0027
                                    38,000

                                 Weeding, Hand
                                      70

                                     0.056
                                    0.00017
                                    590,000
a	Transfer Coefficient taken from Exposure Science Advisory Council (ExpoSAC) Policy No. 3.2: Agricultural Transfer Coefficients (March, 2012).
b	Chemical-Specific DFR Values calculated from original DFR studies on tomatoes (MRID 45409118), squash (MRID 45409119), and grapes (MRID 45409118).
c	Normalized DFR = Study DFR (ug/cm[2] x Application Rate DFR (lb ai/A) / Proposed Application Rate (lb ai/A).
d	Daily Dermal Dose (mg/kg/day) = Normalized DFR (ug/cm[2]) x TC (cm[2]/hr) x exposure time (8 hrs) x dermal abs factor (37%) x CF (1000 ug/mg) / body weight (69 kg).
e	MOE = NOAEL (mg/kg/day) / Daily Dermal Dose (mg/kg/day). ST/IT Dermal NOAEL = 100 mg/kg/day. LOC = 100.
f	Exposure to cyazofamid while hand harvesting potatoes is likely to be from treated soil.  However, TCs are only available for exposure following foliar application.  HED believes the foliar post-application assessment would be protective of hand harvesting following cyazofamid application to potatoes due to the conservative nature of the application rate (0.16 lb ai/A vs. a 0.072 lb ai/A) and the TC (1900 cm[2]/hr).

Appendix E.	International Residue Limit Summary

Table E.  Summary of U.S. and International Tolerances and Maximum Residue Limits
                              Residue Definition
                                     U.S.
                                    Canada
                                   Mexico b
                                     Codex
40 CFR 180.601:
sum of 4-chloro-2-cyano-N,N-dimethyl-5-(4-methylphenyl)-1H-imidazole-1-sulfonamide and its metabolite, 4- chloro-5-(4-methylphenyl)-1H-imidazole-2-carbonitrile, calculated as the stoichiometric equivalent of cyazofamid
4-chloro-2-cyano-N,N-dimethyl-5-(4-methylphenyl)-1H-imidazole-1-sulfonamide, including the metabolite
4-chloro-5-(4-methylphenyl)-1H-imidazole-2-carbonitrile

                                     None
                      Tolerance or Maximum Residue Limit
                                  Commodity a
                                     U.S.
                                    Canada
                                   Mexico b
                                     Codex

                                      ppm
                                     mg/kg
Bean, succulent
                                      0.5

Bean, succulent, shelled
                                     0.08

Leafy greens subgroup 4A
                                      10

Basil, fresh leaves
                                      30

Basil, dried leaves
                                      90

Vegetable, tuberous and corm, subgroup 1C
                                     0.02
                                 0.02 potatoes

Vegetable, fruiting, group 8-10
                                      0.9
                                 0.2 tomatoes

Completed:  M. Negussie, 02/02/2012.
a	Includes only commodities of interest for this action.  Tolerance values should be the HED recommendations and not those proposed by the applicant.
b	Mexico adopts U.S. tolerances and/or Codex MRLs for its export purposes.