  SEQ CHAPTER \h \r 1

April 30, 1999

MEMORANDUM

SUBJECT:	Captan (081301) Reregistration Case No. 0120.  Product and Residue Chemistry Chapters for the Captan Reregistration Eligibility Decision (RED). DP Barcode D255103

FROM:	Thurston Morton, Chemist

		Reregistration Branch 4

Health Effects Division (7509C)

THRU:	Susan Hummel, Branch Senior Scientist

Reregistration Branch 4

Health Effects Division (7509C)

TO:		David Hrdy, Chemist

Reregistration Branch 4

Health Effects Division (7509C)

Kylie Rothwell

Special Review and Reregistration Division (7508W)

Attached are the updated Product and Residue Chemistry Chapters to the Captan RED.  This updates the Chemistry Chapter of 9/7/94 by C. Olinger. The chapters were assembled by Dynamac Corporation (1/6/94) under supervision of HED and addenda since RED production,  incorporated within.  The data assessment has undergone secondary review in the branch and has been revised to reflect branch policies and addenda.

EXECUTIVE SUMMARY:

Product Chemistry

	∙	All pertinent data requirements concerning the captan TGAI are satisfied for Makteshim Agan and Tomen (Captan Task Force) technical products; however, manufacturing-use product (MP) data remain outstanding for these technical products and for the Tomen Formulation Intermediates (FIs) as noted in the data summary tables beginning on page 9 of the Product Chemistry Chapter.

	Also the new data requirement concerning UV/visible absorption for the pure active ingredient (PAI) (OPPTS 830.7050) remains outstanding.

Residue Chemistry

∙	The existing data base for captan is substantially complete.  Plant metabolism data provide adequate identification/characterization of the terminal residues.  Sufficient crop field trial data are available to reassess all tolerances for raw and processed plant commodities.   Based on existing, acceptable data from the livestock metabolism studies in progress, HED concludes the terminal residues in livestock are adequately identified/characterized.  HED  has reassessed the tolerances for livestock commodities and recommend for tolerance increases and new animal commodity tolerances.

Dietary Exposure/Risk Assessment

∙	Anticipated residues will be provided to DEEM for all commodities and should be used when calculating the dietary risk assessment  associated with the RED.  Although the database for captan is substantially complete, additional data are needed to eliminate the uncertainties associated with the exposure/risk assessment as outlined below. The anticipated residue values are the best estimates HED can provide using the residue data available at the time of the RED.  These values have an inherent uncertainty associated with variations in analytical methods, geographical representation of field trials, seasonal variation of residue levels, etc.

cc : Chem F, Chron F. Morton

RDI:Team: 4/30/99; SVH:4/30/99

TM, Thurston Morton, Rm. 816D CM2, 305-6691, mail code 7509C

CAPTAN

REREGISTRATION ELIGIBILITY DOCUMENT:

PRODUCT CHEMISTRY CONSIDERATIONS

(Shaughnessy No. 081301; Case No. 0120)

(DP Barcode D255103)

DESCRIPTION OF CHEMICAL

Captan (N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide) is a broad-spectrum fungicide classified as a dicarboximide or chlorinated organosulfur compound, which is widely used as a seed treatment and has foliar uses on several fruits and almonds.

				Empirical Formula:		C9H8Cl3NO2S

				Molecular Weight:		300.61

				CAS Registry No.:		133-06-2

				Shaughnessy No.:		081301

IDENTIFICATION OF ACTIVE INGREDIENT

Technical captan is a white to buff powder with a melting point of 158-164 C and a vapor pressure of less than 10-6 mm Hg at 25 C.  Captan is practically insoluble in water, and is soluble in acetone, ethanol, kerosene, xylene, chloroform, and benzene.

MANUFACTURING-USE PRODUCTS

A search of the Reference Files System (REFS) conducted 11/30/93 identified seven captan manufacturing-use products (MPs) registered under Shaughnessy No. 081301 which are listed in Table 1.  Only these MPs are subject to a reregistration eligibility decision.

Table 1.	Captan Manufacturing-Use Products

Formulation	EPA Reg. No.	Registrant	Transferred from

EPA Reg. No.	Date

90% FI a	19713-258	Drexel Chemical Company	--	--

90% T	7501-24	Gustafson, Inc.	--	--

92% T b	11678-1	Makhteshim Chemical Works Ltd.	--	--

92% T	New  66330-32

Old  10182-262

32691-1	12/22/87

90% T	New  66330-31

Old  10182-197

476-2099	12/22/87

90% T	New  66330-33

Old  10182-293	Tomen Agro, Inc. c	239-1246	5/25/89

88.92% FI	New  66330-34

Old  10182-198

476-2100	12/22/87

87% FI	10182-298	Canceled 7/19/95	239-2351	5/25/89

a Identified as a technical product in the Captan Update dated 12/31/91.

b Identified as a 90% formulation in the Captan Update dated 12/31/91.

c Formerly Zeneca, Inc.

REGULATORY BACKGROUND

The regulatory background for captan products in terms of comprehensive product chemistry reviews is presented below.

	September 1985 Rereg. Standard

December 1991 Update

	Products

Data required	Data submitted in response

Data required	Data submitted in response

90% FI

(19713-258)	not registered at this time	n/a a	61-1, -2, -3

62-1, -2, -3

63-2 through -20	none

90% T

(7501-24)	61-2, -3

62-1, -2, -3

63-2, -3, -4, -5,

 -7, -8, -11, -12,

 -13	none	61-1, -2, -3

62-1, -2, -3

63-2 through -20	none

92% T

(11678-1)	61-2, -3

62-1, -2, -3	61-1, -2, -3

62-1, -2, -3

63-5, -7, -8,

  -11, -12, -13	63-14, -16, -17,

  -20	none

92% T

(66330-32)	61-2, -3

62-1, -2, -3

63-4, -5, -7, -11,

 -12, -13	none	61-1, -2, -3

62-1, -2, -3

63-2 through -20	61-1

62-2

90% T

(66330-31)	61-2, -3

62-1, -2, -3

63-4, -5, -7, -11,

 -12, -13	61-2, -3

62-1, -3

63-4, -5, -7, -8

  -11, -12, -13	61-1

62-2

63-14, -16, -17,

  -20	61-1

62-2

90% T

(66330-33)	61-2, -3

62-1, -2, -3

63-4, -5, -7, -8,

 -11, -12, -13	61-1, -2, -3

62-1, -2, -3

63-5, -7, -8 -11,

  -12, -13	62-2

63-14, -16,

  -17, -20	61-1

62-2

88.92% FI

(66330-34)	61-2, -3

62-1, -2, -3	61-1, -2, -3

62-1, -2, -3	61-1, -2

62-2

63-2 through -7,

  -12, -14

  through -20	none

a n/a = not applicable.

OPPTS 830 Series Guideline Conversion

1982 Guideline                                                          830 Guideline

	61-1	830.1550

61-2	830.1600/1620/1650

61-3	830.1670

62-1	830.1700

62-2	830.1750

62-3	830.1800

63-2	830.6302

63-3	830.6303

63-4	830.6304

63-5	830.7200

63-6	830.7220

63-7	830.7300

63-8	830.7840/7860

63-9	830.7950

63-10	830.7370

63-11	830.7550/7560/7570

63-12	830.7000

63-13	830.6313

63-14	830.6314

63.15	830.6315

63-16	830.6316

63-17	830.6317

63-18	830.7100

63-19	830.6319

63-20	830.6320

63-21	830.6321

none	830.7050

HED has concluded (CBRS No. 10655, D183104, dated 2/22/93, by R. Perfetti) that the three Tomen technical products are identical, and that data for any one of the three products can be shared by the other two products.  Although Tomen claims that the captan formulation intermediates are similar enough to share data, CSFs on file with the Agency indicate a slight difference in composition.  HED has concluded (CBRS No. 9780, D177146, dated 6/26/92, by C. Olinger) that a justification is required for each data requirement for which the registrant intends to share FI data.

The current status of the product chemistry data requirements for captan products is presented in the attached data summary tables.  Refer to these tables for a listing of the outstanding product chemistry data requirements.

CONCLUSIONS

All pertinent data requirements concerning the captan TGAI are satisfied for the Makhteshim and Tomen technical products; however MP data remain outstanding for these technical products and for the Tomen FIs.  All product chemistry data are required for the Drexel and Gustafson captan products.  Provided that the registrants submit the data required in the attached data summary tables for the captan products and either certify that the suppliers of beginning materials and the manufacturing processes for the captan technical products and MPs have not changed since the last comprehensive product chemistry review or submit complete updated product chemistry data packages, HED has no objections to the reregistration of captan with respect to product chemistry data requirements.

AGENCY MEMORANDA CITED IN THIS DOCUMENT

CBRS No(s).:	2018, 2019, and 2020

DP Barcode(s):	none

Subject:		EPA Nos. 239-1246 (Chevron), 476-2099 (Stauffer), 11678-1 (Makhteshim/Agan):  Captan Technical:  Product Chemistry Data in Response to Registration Standard.

From:		J. Garbus

To:		R. Mountfort and E. Wilson

Dated:		4/2/87

MRID(s):	40021201, 40021202, and 40021301

CBRS No(s).:	2120

DP Barcode(s):	none

Subject:		EPA No. (11678-1):  Captan Technical:  Additional Product Chemistry Data for Makhteshim Material in Response to Registration Standard.

From:		J. Garbus

To:		R. Mountfort and E. Wilson

Dated:		4/27/87

MRID(s):	40121701

CBRS No(s).:	2427

DP Barcode(s):	none

Subject:		EPA Reg No. 239-1246.  Additional Product Chemistry Data for Chevron Captan Technical in Response to Registration Standard.

From:		R. Loranger

To:		R. Mountfort and E. Wilson

Dated:		8/28/87

MRID(s):	40231801

CBRS No(s).:	2472

DP Barcode(s):	none

Subject:		EPA Reg No. 11678-1.  Additional Product Chemistry Data for Makhteshim Captan Technical in Response to Registration Standard.

From:		R. Loranger

To:		R. Mountfort and E. Wilson

Dated:		8/28/87

MRID(s):	40231201 and 40231301

CBRS No(s).:	9780

DP Barcode(s):	D177146

Subject:		Reregistration of Captan:  Captan Task Force Response to the Reregistration Standard Update.

From:		C. Olinger

To:		C. Peterson

Dated:		6/26/92

MRID(s):	none

CBRS No(s).:	10655

DP Barcode(s):	183104

Subject:		Response to the Captan Reregistration Standard:  Product Chemistry.

From:		R. Perfetti

To:		L. Rossi and E. Saito

Dated:		2/22/93

MRID(s):	none

PRODUCT CHEMISTRY CITATIONS

Bibliographic citations include only MRIDs containing data which fulfill data requirements.  One additional MRID which did not satisfy the stability requirement (830.6313), is included in bold type at the end of this section.

References (cited):

40021201 Chevron Chemical Co. (1986) Analysis and Certification of Product Ingredients:  Project I.D. 8615386.  Unpublished compilation.  73 p.

40021202 Chevron Chemical Co. (1986) Physical and Chemical Characteristics:  Project I.D. 8615387.  Unpublished compilation.  57 p.

40021301 Chevron Chemical Co. (1986) Product Identity and Composition:  Laboratory Project ID. 8615385.  Unpublished compilation.  127 p.

40121701 Makhteshim Chemical Works Ltd. (1987) Product Chemistry:  Translation from French to English Merpan Captan Technical:  MCW 10002.  Unpublished study.  15 p.

40141501 Wegner, M. (1987)  Beginning Materials, Manufacturing Process, Formation of Impurities and Certification of Ingredient Limits:  Captan 90 Dust Base:  Project No. RRC 87-34.  Unpublished compilation prepared by Stauffer Chemical Co.  14 p.

40141502 Bussey, R. (1987)  Preliminary Analysis of Product Samples Captan 90 DB:  Project No. 87-02.  Unpublished compilation prepared by Stauffer Chemical Co. 20 p.

40141503 Riggs, R. (1987)  Analytical Methods to Verify Certified Limits:  Captan 90 Dust Base:  Project No. PRS-RLR-870326.  Unpublished compilation prepared by Association of Official Analytical Chemists in cooperation with Chevron Chemical Co.  15 p.

40231201 Makhteshim Chemical Works Ltd. (1987) Additional Product Chemistry Data:  Merpan Captan Technical:  Makhteshim-Agan Project ID:  MCW 10001.  Unpublished study.  10 p.

40231301 Makhteshim Chemical Works Ltd. (1987) Additional Product Chemistry Data:  Merpan Captan Technical:  Makhteshim-Agan Project ID:  MCW 10001.  Unpublished study.  16 p.

40231801 Thornberry, N. (1987) Physical and Chemical Characteristics:  Captan Technical:  Laboratory Project ID:  8709737.  Unpublished study prepared by Chevron Chemical Co.  4 p.

42301401 Haefele, L. (1992) Storage Stability Study: Drexel Captan 90% Technical.  Unpublished study prepared by Drexel Chemical Co.  6 p.

Case No. 0120

Chemical No. 081301

Case Name: Captan

Registrant: Drexel Chemical Company

Product(s): 90% FI (EPA Reg. No. 19713-258)

PRODUCT CHEMISTRY DATA SUMMARY

Guideline

Number

Requirement	Are Data Requirements Fulfilled? a

MRID Number

830.1550	Product Identity and Disclosure of Ingredients	N

	830.1600

830.1620

830.1650	Starting Materials and Manufacturing Process	N

	830.1670	Discussion of Formation of Impurities	N

	830.1700	Preliminary Analysis	N

	830.1750	Certification of Ingredient Limits	N

	830.1800	Analytical Methods to Verify the Certified Limits	N

	830.6302	Color	N

	830.6303	Physical State	N

	830.6304	Odor	N

	830.6313	Stability	Nb 	42301401

830.6314	Oxidation/Reduction	N

	830.6315	Flammability	N

	830.6316	Explodability	N

	830.6317	Storage Stability	N

	830.6319	Miscibility	N

	830.6320	Corrosion Characteristics	N

	830.7000	pH	N

	830.7050	UV/Visible Absorption	N/A

	830.7100	Viscosity	N

	830.7200	Melting Point/Melting Range	N

	830.7220	Boiling Point/Boiling Range	N

	830.7300	Density/Relative Density/Bulk Density	N

	830.7370	Dissociation Constant in Water	N

	830.7550

830.7560

830.7570	Partition Coefficient (Octanol/Water)	N

	830.7840

830.7860	Solubility	N

	830.7950	Vapor Pressure	N

a Y = Yes; N = No; N/A = Not Applicable.

b These data do not satisfy the data requirements of 40 CFR §158.190 (Guideline Reference  No. 830.6313) concerning storage stability because data are required on stability to heat, metal/metal ions, and light. Data were presented only on stability at ambient conditions in an unspecified container. There was no appreciable decrease in captan concentration over 18 months.

Case No. 0120

Chemical No. 081301

Case Name: Captan

Registrant: Gustafson, Inc.

Product(s): 90% T (EPA Reg. No. 7501-24)

PRODUCT CHEMISTRY DATA SUMMARY

Guideline

Number

Requirement	Are Data Requirements Fulfilled? a

MRID Number

830.1550	Product Identity and Disclosure of Ingredients	N

	830.1600

830.1620

830.1650	Starting Materials and Manufacturing Process	N

	830.1670	Discussion of Formation of Impurities	N

	830.1700	Preliminary Analysis	N

	830.1750	Certification of Ingredient Limits	N

	830.1800	Analytical Methods to Verify the Certified Limits	N

	830.6302	Color	N

	830.6303	Physical State	N

	830.6304	Odor	N

	830.6313	Stability	N

	830.6314	Oxidation/Reduction	N

	830.6315	Flammability	N

	830.6316	Explodability	N

	830.6317	Storage Stability	N

	830.6319	Miscibility	N

	830.6320	Corrosion Characteristics	N

	830.7000	pH	N

	830.7050	UV/Visible Absorption	N

	830.7100	Viscosity	N

	830.7200	Melting Point/Melting Range	N

	830.7220	Boiling Point/Boiling Range	N

	830.7300	Density/Relative Density/Bulk Density	N

	830.7370	Dissociation Constant in Water	N

	830.7550

830.7560

830.7570	Partition Coefficient (Octanol/Water)	N

	830.7840

830.7860	Solubility	N

	830.7950	Vapor Pressure	N

a Y = Yes; N = No; N/A = Not Applicable.

Case No. 0120

Chemical No. 081301

Case Name: Captan

Registrant:  Makhteshim Chemical Works, Ltd.

Product(s): 92% T (EPA Reg. No. 11678-1)

PRODUCT CHEMISTRY DATA SUMMARY

Guideline

Number

Requirement	Are Data Requirements Fulfilled? a

MRID Number b

830.1550	Product Identity and Disclosure of Ingredients	Y	CSFc

830.1600

830.1620

830.1650	Starting Materials and Manufacturing Process	Y 	40121701 40231301

830.1670	Discussion of Formation of Impurities	Y 	40121701

830.1700	Preliminary Analysis	Y 	40021201

830.1750	Certification of Ingredient Limits	Y 	CSFc

830.1800	Analytical Methods to Verify the Certified Limits	Y 	40021201

830.6302	Color	Y 	N/A

830.6303	Physical State	Y 	N/A

830.6304	Odor	Y 	N/A

830.6313	Stability	Y	40231201

830.6314	Oxidation/Reduction	N

	830.6315	Flammability	N/A

	830.6316	Explodability	N

	830.6317	Storage Stability	N

	830.6319	Miscibility	N/A

	830.6320	Corrosion Characteristics	N

	830.7000	pH	Y 	40231201

830.7050	UV/Visible Absorption	N/A

	830.7100	Viscosity	N/A

	830.7200	Melting Point/Melting Range	Y	40231201

830.7220	Boiling Point/Boiling Range	N/A

	830.7300	Density/Relative Density/Bulk Density	Y 	40231201

830.7370	Dissociation Constant in Water	N/A

	830.7550

830.7560

830.7570	Partition Coefficient (Octanol/Water)	Y	40021202

830.7840

830.7860	Solubility	Y	40231201

830.7950	Vapor Pressure	Y	N/A

a Y = Yes; N = No; N/A = Not Applicable.

b Bolded citations were reviewed under CBRS No. 2018, 2019, and 2020, dated 4/2/87, by J. Garbus; underlined citations were reviewed under CBRS No. 2120, dated 4/27/87, by J. Garbus; italicized citations were reviewed under CBRS No. 2472, dated 8/28/87, by R. Loranger.

c Data were initially addressed under CBRS No. 2120, dated 4/27/87, by J. Garbus, but were re-evaluated when data required for other guidelines were submitted under CBRS No. 2472, dated 8/28/87, by R. Loranger.

Case No. 0120

Chemical No. 081301

Case Name: Captan

Registrant: Tomen

Product(s): 90% T (EPA Reg. Nos. 66330-31, 66330-32, and 66330-33)

PRODUCT CHEMISTRY DATA SUMMARY

Guideline

Number

Requirement	Are Data Requirements Fulfilled? a

MRID Numberb

830.1550	Product Identity and Disclosure of Ingredients	Y b	CSF 9/15/92 c

830.1600

830.1620

830.1650	Starting Materials and Manufacturing Process	Y 	40021301

830.1670	Discussion of Formation of Impurities	Y 	40021301

830.1700	Preliminary Analysis	Y 	40021201

830.1750	Certification of Ingredient Limits	Y	CSF 9/15/92 c

830.1800	Analytical Methods to Verify the Certified Limits	Y 	40021201

830.6302	Color	Y 	N/A

830.6303	Physical State	Y 	N/A

830.6304	Odor	Y 	40021202

830.6313	Stability	Y 	40021202 40231801

830.6314	Oxidation/Reduction	N

	830.6315	Flammability	N/A

	830.6316	Explodability	N

	830.6317	Storage Stability	N

	830.6319	Miscibility	N/A

	830.6320	Corrosion Characteristics	N

	830.7000	pH	Y 	40021202 40231801

830.7050	UV/Visible Absorption	N

	830.7100	Viscosity	N/A

	830.7200	Melting Point/Melting Range	Y 	40021202 40231801

830.7220	Boiling Point/Boiling Range	N/A 	N/A

830.7300	Density/Relative Density/Bulk Density	Y 	40021202 40231801

830.7370	Dissociation Constant in Water	N/A

	830.7550

830.7560

830.7570	Partition Coefficient (Octanol/Water)	Y 	40021201

830.7840

830.7860	Solubility	Y 	40021202 40231801

830.7950	Vapor Pressure	Y 	N/A

a Y = Yes; N = No; N/A = Not Applicable.  The Agency has concluded (CBRS No. 10655, D183104, dated 2/22/93 by R. Perfetti) that the three Zeneca (now Tomen) technical products are identical, and that data for any one of the three products can be shared by the other two products.

b Bolded citations were reviewed under CBRS No. 2018, 2019, and 2020, dated 4/2/87, by J. Garbus; underlined citations were reviewed under CBRS No. 2427, dated 8/28/87, by R.. Loranger; and the remaining citations were reviewed under CBRS No. 10655, D183104, dated 2/22/93, by R. Perfetti.

Case No. 0120

Chemical No. 081301

Case Name: Captan

Registrant: Tomen

Product(s): 88.92% FI (EPA Reg. No. 66330-34)

PRODUCT CHEMISTRY DATA SUMMARY

Guideline

Number

Requirement	Are Data Requirements Fulfilled? a

MRID Numberb

830.1550	Product Identity and Disclosure of Ingredients	Nc	40141501

830.1600

830.1620

830.1650	Starting Materials and Manufacturing Process	Nd 	40141501

830.1670	Discussion of Formation of Impurities	Y 	40141501

830.1700	Preliminary Analysis	N/Ae

	830.1750	Certification of Ingredient Limits	Nf	40141501

830.1800	Analytical Methods to Verify the Certified Limits	Y 	40141502 40141503

830.6302	Color	N

	830.6303	Physical State	N

	830.6304	Odor	N

	830.6313	Stability	N/Ae

	830.6314	Oxidation/Reduction	N

	830.6315	Flammability	N

	830.6316	Explodability	N

	830.6317	Storage Stability	N

	830.6319	Miscibility	N

	830.6320	Corrosion Characteristics	N

	830.7000	pH	N

	830.7050	UV/Visible Absorption	N/A

	830.7100	Viscosity	N

	830.7200	Melting Point/Melting Range	N/Ae

	830.7220	Boiling Point/Boiling Range	N/Ae

	830.7300	Density/Relative Density/Bulk Density	N

	830.7370	Dissociation Constant in Water	N/Ae

	830.7550

830.7560

830.7570	Partition Coefficient (Octanol/Water)	N/Ae

	830.7840

830.7860	Solubility	N/Ae

	830.7950	Vapor Pressure	N/Ae

a Y = Yes; N = No; N/A = Not Applicable.

bAll citations were reviewed in the Captan Reregistration Standard Update dated 12/31/91.

cThese data do not satisfy the data requirements of 40 CFR §158.155 (Guideline Reference No. 830.1550) concerning product composition because the nominal concentration of the active ingredients (captan and related derivatives) must be revised to represent the level of the active ingredients in the final product based on the concentration of the active ingredients in the technical source product.

dThese data do not satisfy the data requirements of 40 CFR §158.160-165 (Guideline Reference No. 830.1600, 1620, 1650) concerning the starting materials and manufacturing process because a specification sheet for an inert ingredient must be submitted.

eThese data requirements will be satisfied by the technical source product.

fThese data do not satisfy the data requirements of 40 CFR §158.175 (Guideline Reference No. 830.1750) concerning certified limits because an updated CSF on EPA Form 8570-4 (Rev. 12-90) is required reflecting transfer of ownership.

CAPTAN

REREGISTRATION ELIGIBILITY DOCUMENT

RESIDUE CHEMISTRY CONSIDERATIONS

(Shaughnessy No. 081301; Case 0120)

(DP Barcode D255103)

TABLE OF CONTENTS	page

 TOC \f

INTRODUCTION	 18

REGULATORY BACKGROUND	 18

SUMMARY OF SCIENCE FINDINGS	 20

GLN 860.1200: Directions for Use	 20

GLN 860.1300: Plant Metabolism	 20

GLN 860.1300:  Animal Metabolism	 20

GLN 860.1340 (c/d):  Residue Analytical Methods - Plants and Animals	 21

GLN 860.1380:  Storage Stability	 21

	GLN 860.1480: Magnitude of the Residue in Meat, Milk, Poultry, and Eggs  22

GLN 860.1500: Magnitude of the Residue in Plants	 22

GLN 860.1520: Magnitude of the Residue in Processed Food/Feed	 22

GLNs 860.1850 and 860.1900: Confined/Field Rotational Crops	 22

TOLERANCE REASSESSMENT SUMMARY	 44

Tolerances Currently Listed Under 40 CFR §180.103(a)	 44

Tolerances Listed Under 40 CFR §185.500	 45

CODEX HARMONIZATION	 51

DIETARY EXPOSURE REASSESSMENT	 53

AGENCY MEMORANDA CITED IN THIS DOCUMENT	 53

MASTER RECORD IDENTIFICATION NUMBERS	 57

CAPTAN

REREGISTRATION ELIGIBILITY DOCUMENT

RESIDUE CHEMISTRY CONSIDERATIONS

(Shaughnessy No. 081301; Case 0120)

(DP Barcode D255103)

INTRODUCTION tc "INTRODUCTION"

Captan (N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide) is a fungicide registered for foliar applications to almonds, apples, apricots, blueberries, caneberries, cherries, grapes, nectarines, peaches, plums, and strawberries; post-harvest fruit dip on apples, cherries, and pears; and seed treatment of numerous food and feed crops.  These are the only use patterns to be supported by the Captan Task Force comprised of Mahketeshim-Agan and Tomen Agro, Inc., formerly Zeneca, Inc., (letter from Zeneca dated 2/3/94) and are detailed in Table A (amended 2/5/97, C. Olinger, D228077).  Formulations registered for field application are the 50 and 80% wettable powder (WP), the 75% water-dispersible granules (WDG), and the 4 lb/gal flowable concentrate (FlC).  Several dusts (D) and WPs and a 4 lb/gal FlC are registered for seed treatments [Source: REFS search dated 5/04/94; active end-use product labels.]

Tolerances for residues in/on numerous plant and animal commodities are currently expressed in terms of captan per se (a complete list of commodities with tolerances is provided in Table C).

REGULATORY BACKGROUND tc "REGULATORY BACKGROUND"

A Special Review Data Call-In Notice (DCI) was issued 4/29/85 for captan requiring a number of studies to be used by the Agency in refining dietary exposure assessments.

Captan was the subject of a Reregistration Standard and Guidance Document issued 3/86.  The Guidance Document specified numerous residue chemistry data gaps.  The Captan Reregistration Standard Update dated 12/31/91 summarizes data submitted in response to the DCI and Guidance Document and specified remaining data gaps and needed label amendments.  The information contained in this document outlines the Residue Chemistry Science Assessments with respect to the reregistration of captan.

Issues

The Position Document 1 (PD1) published in 1980 (45 FR 54938) outlined the oncogenic, teratogenic, and reproductive effects of captan.  The PD2/3 (1985) summarized the potential risks and benefits of captan use.  The PD2/3 recommended the cancellation of all foliar and postharvest food/feed uses of captan and retention of seed treatment uses.  However, additional data were required to support established tolerances and to determine the actual food residues.  In addition the PD2/3 stated that uses would be retained where submitted data demonstrate that actual residues are lower than the established tolerance or in cases where modified use patterns would reduce dietary risk.

The Agency's Special Review and Risk/Benefit Analysis concluded that retention of all food uses of captan would result in unreasonable adverse effects on humans or the environment.  Consequently, the Agency announced (PD4; FR Notice of 2/24/89, Vol. 54, No. 36, p. 8116) a notice of intent to cancel the registrations of all products containing captan as the active ingredient with the following exceptions:  (I) all non-food uses;  (ii) seed treatments; and (iii) the following food uses:  almonds, apples, apricots, cherries, grapes, pears, plums, strawberries, nectarines, pears (postharvest), and peaches, plus several uses not canceled, but subject to suspension.  Those use sites subject to suspension were blackberries, blueberries, celery (plant-bed), dewberries, eggplant (plant bed), lettuce, mangoes, green onions, peppers and pimentos (plant bed), raspberries, spinach (plant bed), taro, and tomatoes (plant bed).  These uses were suspended due to insufficient residue data reflecting these use patterns.  The use on blueberries is being supported by the Captan Task Force.  The use on caneberries (blackberries, dewberries, and raspberries) is being retained with supporting data provided by IR-4.  Foliar uses on lettuce, mangoes, and green onions and plant-bed use registrations listed in the PD4 as subject to suspension are not being supported by the Captan Task Force.

The HED Metabolism Committee (C. Olinger and P. Chin, 4/1/94) has ruled that the tolerance expression for animal commodities is to be revised to include the metabolite 1,2,3,6-tetrahydrophthalimide (THPI) as well as captan.  Captan per se is to remain the only residue regulated by tolerances in raw and processed plant commodities.  The structures of captan and THPI are shown below.

Captan	THPI

SUMMARY OF SCIENCE FINDINGS tc "SUMMARY OF SCIENCE FINDINGS"

The summaries of residue chemistry guidelines and topics listed below are based on the present regulatory status where the only registered food/feed uses of captan are those to be retained by the Captan Task Force.  HED reserves the right to require additional studies for each applicable guideline and topic if additional registrations on food/feed crops are sought.  A complete summary of residue chemistry data requirements for the reregistration of captan, in accordance with OPPTS Test Guidelines Series 860, appears in Table B.

GLN 860.1200: Directions for Use  tc "GLN 860.1200\: Directions for Use " \l 2 :  There are 30 end-use products (EP) of captan currently registered by Tomen (formerly Zeneca) for food/feed crops [Source:  REFS search conducted 4/05/99].  Only WP, FlC, and WDG formulations are registered for foliar applications.  Dusts, in addition to the aforementioned formulation classes, are registered for seed treatment.  The only foliar (or post-harvest dip) uses are on apples, pears, grapes, strawberries, cherries, peaches, almonds, apricots, caneberries, plums, and blueberries. A comprehensive summary of registered food/feed use patterns based on these product labels is presented in Table A (EPA Reg. Nos. 66330-26, -10, -1, -11, -27, -12, -28, -23, -24, -2, -3,  -4, -25, -5, -13, -14, -15, -16, -17, -18, -19, -6, -20, -7, -8, -21, -22, -9, -30; uses permitted under CA930007 for foliar application to pears and SC920001 for chemigation of strawberries were also used).  CA930007 is listed in REFS (4/27/99) as cancelled. Zeneca has requested voluntary cancellation of 10182-153, -313 and -314 in a letter dated 10/25/93 and products 10182-289, -295, -305, and -315 in a letter dated 2/24/94.  These products were still considered active in a REFS search conducted 5/04/94. Product 70-190 is still listed as active in REFS (4/27/99). Foliar use on pears must be cancelled on this product because the PD4 disallowed this use. Also 239-568 has a foliar use on pears. In REFS this is listed as Ortho Home Orchard Spray. Use on pears was disallowed in the PD4. A risk management decision by SRRD would have to be made whether PD4 apply to home uses also. Uses cancelled in the PD4 must be deleted from the labels.

The conclusions regarding the reregistration eligibility of captan on the crops listed in Table B are based on the use patterns registered by members of the Captan Task Force for which residue data are available reflecting these use patterns.  Modifications are still required for some Zeneca labels including maximum seasonal use rates, pre-harvest intervals, and other use restrictions.  When end-use product DCIs are developed (e.g., at issuance of the RED), RD should require that all end-use product labels (e.g., MAI labels, SLNs, and products subject to the generic data exemption) be amended such that they are consistent with the basic producer labels.

GLN 860.1300: Plant Metabolism  tc "GLN 860.1300\: Plant Metabolism " \l 2 :  The qualitative nature of the residue in plants is adequately understood based on acceptable lettuce and tomato metabolism studies.  These studies indicated that captan is cleaved at the N-S bond to form THPI, which is further metabolized.  The metabolite of the cleaved side chain is carbon dioxide (CO2), which may be reincorporated into plant constituents.  Captan is the major residue in tomato fruits and lettuce comprising 55-81% of the total radioactive residue (TRR).  Minor residues include THPI, (4-9% of the TRR), captan epoxide, (0.4%), and THPI epoxide (0.9%).  Bis(trichloromethyl)disulfide, trans-3-hydroxy-1,2,6-trihydrophthalimide (3-OH-THPI), and trans-5-hydroxy-1,2,6-trihydrophthalimide (5-OH-THPI) may be present at very low levels.  The residue of concern in raw and processed plant commodities is captan per se.

GLN 860.1300:  Animal Metabolism  tc "GLN 860.1300\:  Animal Metabolism " \l 2 : The qualitative nature of the residue in animals is adequately understood, based on acceptable poultry and ruminant metabolism studies with cyclohexyl ring-labeled (CHR) [14C]captan.  No captan was detected in tissues, milk, or eggs.  The major residues in goat muscle, liver, kidney and milk are 3-OH-THPI and 5-OH-THPI; in addition THPI was a major residue in goat fat.  THPI was the major residue in hen matrices.  Captan metabolism in livestock proceeds through rapid cleavage of the trichloromethyl moiety, followed by oxidation and hydroxylation of the cyclohexyl ring.  The trichloromethyl carbon is taken up into the single carbon pool and incorporated into natural constituents. Sufficient data are available to assess the dietary risk from animal commodities bearing captan residues. The residues of concern in animals are captan and THPI.

GLN 860.1340:  Residue Analytical Methods - Plants and Animals  tc "GLN 860.1340\:  Residue Analytical Methods - Plants and Animals " \l 2 :  Adequate methodology is available for enforcement of tolerances residues of captan per se in/on plant commodities.  A GC/electron capture detection (EC) method included in PAM, Vol. II as Method I is the preferred enforcement method.  Other methods in PAM Vol. II that use colorimetry to analyze surface residues from plant tissues are not acceptable.  Data submitted to support crop tolerances and in response to the DCI (residue reduction) were collected using the following GC methods:  Chevron Methods No. RM-1K-1 and RM-1K-2 for captan and THPI, Stauffer Method No. RRC-76-30R for captan and RRC-78-20 for THPI, and Zeneca (formerly ICI) Method No. WRC 89-51 for captan and THPI.

Zeneca Method No. 166 for quantifying THPI in meat and milk has been validated for use in tolerance enforcement.  This method has also been used for data collection and is adequate for that purpose.

Captan is completely recovered (>80%) using PAM Vol. I Multiresidue Protocol E, Section 211.1 for oily matrices and partially recovered (50-85%) using Protocol E Section 212.1 for non-oily matrices.  Captan is completely recovered using Multiresidue Protocol D (Luke Method; 232.4).  THPI is completely recovered through Protocol D, but not through Protocol E (PESTDATA, PAM, Vol. 1, Appendix, 8/93).

GLN 860.1380:  Storage Stability  tc "GLN 860.1380\:  Storage Stability " \l 2 :  Storage stability studies have been conducted with crop matrices.  The stability of captan is somewhat dependent on the extent of sample preparation.  Captan per se is stable for periods of 3-14 months in whole almonds, apples, apple juice, apple sauce, grape dry pomace, raisins, spinach, strawberries, sugar beet tops, tomato dry pomace, and tomato sauce, and for 3 months in cherries and wheat forage.  Captan per se was not stable in almonds, corn grain, or spinach that had been ground prior to fortification or in beet tops, whole corn grain, cucumbers, lettuce, potatoes, soybean seed and forage, or tomatoes.  As captan degrades to THPI, which exhibits greater stability, the total captan plus THPI residues can show the overall stability of total residues.  Captan plus THPI residues were stable for 9-15 months on whole almonds, apples, apple juice, applesauce, beet tops, cherries, cucumbers, grape dry pomace, raisins, soybean forage, chopped spinach, strawberries, sugar beet tops, tomato dry pomace, tomato sauce, and wheat forage.  Combined residues were stable for 3-6 months in lettuce, potatoes, and soybean grain, and for 1-2 months in ground almonds, ground corn grain, and finely chopped spinach.  The data are adequate to support the residue data submitted to support foliar applications and seed treatments.  Additional storage stability data may be required to support any new magnitude of residue data submitted in the future.

Sufficient storage stability data are available to support the residue data for milk.  THPI residues are stable in animal tissues for 3 years when results are corrected for concurrent method recoveries (D214345, D222419; C. Olinger, 5/30/96). No additional storage stability data are required for animal commodities.

GLN 860.1480: Magnitude of the Residue in Meat, Milk, Poultry, and Eggs:  Cattle feeding studies have been evaluated and found adequate to satisfy ruminant feeding study data requirements.  Using Table 1 GLN 860.1000, the maximum theoretical dietary burden for dairy cattle is 17.27 ppm and beef cattle is 27.72 ppm, based on residue contributions from wet apple pomace (40% dry matter), almond hulls, and RAC’s from seed treatment.  The feeding study data represent daily dietary levels of 10, 30, and 100 ppm and are adequate for assessing the established tolerances and establishing a new tolerance for milk.

Table 2.  Estimated Dietary Burden

Commodity	Captan + THPI

(ppm)	% in Diet

% Dry Matter	Average Dietary Burden, ppm

	Dairy	Beef

Dairy	Beef

Almond Hulls	60 1	10	10	90	6.67	6.67

Apple Pomace, wet	20.82	20	40	40	10.40	20.80

RAC's from seed treatment (grass, corn, cottonseed, small grain etc.) 0.1 3	40	50	20 4	0.20	0.25

TOTAL

70	100

17.27	27.72

1 The maximum residue found at a 1x rate in FT for almond hulls was 60 ppm captan + THPI.

2 The maximum residue found at a 1x rate in FT for apples was 15.9 ppm captan + THPI.

   Apple pomace: 20.8(16x1.3 avg. conc. factor for captan + THPI)

3  Limit of detection for THPI plus limit of detection for captan, 0.05 ppm + 0.05 ppm.

4  Maximizes residue.  20% is the percent dry matter for potato culls. Other rac's typically have higher percent dry matter.

A poultry feeding study is not required.  Using Table 1 GLN 860.1000, the only poultry feed items which remain are those grown from captan treated seed.  Since residues of captan and THPI are not detectable in the poultry feed items, poultry feeding studies and tolerances will not be required.

GLN 860.1500: Magnitude of the Residue in Plants:  All data requirements for magnitude of the residue in plants have been evaluated.   Data are adequate to reassess captan tolerances in light of canceled and revised uses.  Field data on fruit and nut orchard crops and grapes are available reflecting multiple foliar applications of WP, FlC, or WDG formulations with appropriate PHIs and geographic representation.  Data on postharvest fruit dip are available for apples, cherries, and pears.  Data from seed treatments using WP/FlC and D formulations on representative crop seed and potato seed pieces indicate that these uses will not result in detectable residues of captan in/on edible commodities.

In addition, the Task Force is not supporting the EC/SC (5887-167) foliar use on apples, cherries, grapes, peaches, and (4-122) on strawberries. Data will be required to support these uses or they must be deleted from the product label. These data are considered confirmatory.

GLN 860.1520: Magnitude of the Residue in Processed Food/Feed  tc "GLN 860.1520\: Magnitude of the Residue in Processed Food/Feed " \l 2 :  All data requirements for magnitude of the residue in processed food/feed have been evaluated and deemed adequate to determine the extent to which residues concentrate in food/feed items upon processing of the raw agricultural commodity.  Captan residues tend to concentrate in raisins and raisin waste.  Raisin waste is no longer a significant feed item per Table 1 OPPTS GLN 860.1000, therefore, no feed tolerance is required. Residues tend to reduce or convert to THPI in all other processed commodities.

GLN 860.1560: Reduction of Residue:  Data pertaining to reduction of captan residues on plant commodities were submitted in response to the Special Review of captan.  Studies conducted on apples, cantaloupe, cucumbers, grapefruit, lemons, lettuce, oranges, squash, strawberries, and spinach indicate that residues are substantially reduced by washing and are almost non-detectable after peeling.  Cooking studies on celery, cucumbers, squash, and spinach indicate that residues of captan are almost non-detectable after cooking, with a corresponding increase in the THPI residues.

GLNs 860.1850 and 860.1900: Confined/Field Rotational Crops  tc "GLNs 860.1850 and 860.1900\: Confined/Field Rotational Crops " \l 2 :  Confined rotational crop studies were reviewed previously by EFGWB and judged unacceptable due to low field application rates.  However, since the EFGWB review, captan use patterns have become more restrictive, such that the only uses pertinent to rotational crops are seed treatments.  There are no captan uses on annual crops.  The studies have been reconsidered under the current use patterns, and it has been concluded that no detectable residues of captan or THPI are likely in rotated crops and that no field rotational crop data or tolerances for rotated crops are required.

Table A.	Use patterns subject to reregistration for:  Case 0120, Captan.

SITE

Application Type

Application Timing

Application Equipment	Maximum Application Rate

(ai)	Form	Maximum  Seasonal Rate

 (ai)	Minimum Retreatment Interval (days)	PHI

(days)	Use Limitations

Alfalfa, Clover

Seed treatment

Slurry	4 oz/cwt	WP, FlC	NAa	NA	NA

	Seed treatment

Dust	6 oz/cwt	D

Seed treatment

Planter box	0.25 oz/cwt	D

Almonds

Foliar

Ground and aerial equipment	5 lb/A	WP, FlC, WDG	26.25 lb/A	NSb	30

	Apples

Foliar

Ground and aerial equipment	4 lb/A	FlC, WDG, WP	32 lb/A	5	0	Eastern U.S.

	32 lb/A	NS	0	Western U.S.

Postharvest fruit dip	1.25 lb/

100 gal	WP, FlC, WDG	NA	NA	NA

	Apricots

Foliar

Ground and aerial equipment	2.5 lb/A	WP, FlC, WDG	12.5 lb/A	NS	0

	Barley

Seed treatment

Dust or slurry	1.5 oz/cwt	D, WP,  FlC	NA	NA	NA

	Seed treatment

Planter box

	0.8 oz/cwt c	D

Beans

Seed treatment

Slurry	1.3 oz/cwt	WP, FlC	NA	NA	NA

	Seed treatment

Dust	1.9 oz/cwt	D

Seed treatment

Planter box	0.25 oz/cwt	D

Beets (table)

Seed treatment

Slurry	6 oz/cwt	WP, FlC	NA	NA	NA

	Seed treatment

Dust	9 oz/cwt	D

Blueberries

Foliar

Ground and aerial equipment	2.5 lb/A	WP, FlC, WDG	35 lb/A	7	0

Bluegrass

Seed treatment

Slurry	4.1 oz/cwt	WP, FlC	NA	NA	NA

	Seed treatment

Dust	6 oz/cwt	D

Broccoli, Brussels sprouts, cabbage, cauliflower

Seed treatment

Dust or slurry	1.1 oz/cwt	D, WP, FlC 	NA	NA

	NA

	Seed treatment

Planter box	0.25 oz/cwt	D

Carrots

Seed treatment

Slurry	4.4 oz/cwt	WP, FlC 	NA	NA	NA

	Seed treatment

Dust	6.75 oz/cwt	D

Seed treatment

Planter box	0.5 oz/cwt	D

Cantaloupe, cucumber

Seed treatment

Slurry	1.6 oz/cwt	WP, FlC 	NA	NA	NA

	Seed treatment

Dust	2.25 oz/cwt	D

Seed treatment

Planter box	0.5 oz/cwt	D

Cherries

Foliar

Ground and aerial equipment	2 lb/A	WP, FlC, WDG	14 lb/A	3	0	Eastern U.S.

NS	0	Western U.S.

Postharvest fruit dip	1.25 lb/

100 gal	WP, FlC, WDG	NA	NA	NA

	Corn (field)

Seed treatment

Dust or slurry	1.1 oz/cwt	D, WP, FlC 	NA	NA	NA

	Corn (sweet)

Seed treatment

Dust or slurry	2 oz/cwt	D, WP, FlC 	NA	NA	NA

	Corn (unspecified)

Seed treatment

Planter box	1 oz/cwt	D	NA	NA	NA

	Cotton, acid delinted

Seed treatment

Slurry	2.5 oz/cwt	FlC, WP	NA	NA	NA

	Seed treatment

Dust	1.5 oz/cwt	D

Cotton, machine delinted

Seed treatment

Dust or slurry	2.25 oz/cwt	D, WP, FlC 	NA	NA	NA

	Cotton, fuzzy

Seed treatment

Slurry or dust	2.25 oz/cwt	D, WP	NA

	NA	NA

	Seed treatment

Slurry	3.5 oz/cwt	FlC, WP

Cotton, reginned

Seed treatment

Slurry	3.5 oz/cwt	FlC	NA	NA	NA

	Cotton (unspecified)

Seed treatment

Planter box	1 oz/cwt	D	NA	NA	NA

	Cowpeas

Seed treatment

Slurry	1.5 oz/cwt	WP, FlC

NA	NA

	Seed treatment

Dust	2.25 oz/cwt	D

Eggplant

Seed treatment

Slurry	2.7 oz/cwt	WP 	NA	NA	NA

	Seed treatment

Dust	4.5 oz/cwt	D

Flax

Seed treatment

Slurry	2 oz/cwt	WP, FlC 	NA	NA	NA

	Seed treatment

Dust	2.6 oz/cwt	D

Seed treatment

Planter box	0.25 oz/cwt	D

Grapes

Foliar

Ground and aerial equipment	2 lb/A	WP, FlC, WDG	12 lb/A	10	0	U.S. exc. CA

NS	0	CA

Grasses

Seed treatment

Slurry	4.1 oz/cwt	WP, FlC	NA	NA	NA

	Seed treatment

Dust	9 oz/cwt	D

Mustard, rape

Seed treatment

Slurry	0.8 oz/cwt	WP, FlC	NA	NA	NA

	Nectarines

Foliar

Ground and aerial equipment	4 lb/A	WP, FlC, WDG	24 lb/A	3	0	U.S.

Oats

Seed treatment

Dust or slurry	2 oz/cwt	WP,  FlC 	NA	NA	NA

	Seed treatment

Planter box	0.8 oz/cwt	D

Okra

Seed treatment

Planter box

	0.5 oz/cwt	D	NA	NA	NA

	Onion

Pelleting	0.8 lb/lb seed	D, FlC	NA	NA	NA

	Seeder box treatment	0.75 lb/3 lb seed	D, WP, FlC

Peaches

Pre-Plant Root Dip	2 lb/100 gal water	WP, WDG	NA	NA	NA	CA

Foliar

Ground and aerial equipment	4 lb/A	WP, FlC, WDG	32 lb/A	3	0	U.S.

Peanuts

Seed treatment

Dust or slurry	3 oz/cwt	D, FlC, WP	NA	NA	NA

	Pears

Canceled use per PD4. Foliar

Ground and aerial equipment	3 lb/A	WP	NS	NS	14	CA only under EPA SLN No. CA 930007

Postharvest fruit dip	1.25 lb/

100 gal	WP, FlC, WDG	NA	NA	NA

	Peas

Seed treatment

Slurry	1.3 oz/cwt	WP, FlC 	NA	NA	NA

	Seed treatment

Dust	1.9 oz/cwt	D

Seed treatment

Planter box	0.5 oz/cwt	D

Peppers

Seed treatment

Slurry	1.5 oz/cwt	WP, FlC	NA	NA	NA

	Seed treatment

Dust	2.25 oz/cwt	D

Plums/Fresh prunes

Foliar

Ground and aerial equipment	3 lb/A	WP, FlC, WDG	27 lb/A	7	0	Eastern U.S.

	27 lb/A	NS	0	Western U.S.

Potatoes

Seed piece treatment

Dust	1.2 oz/cwt	D	NA	NA	NA

Radish

Seed treatment

Dust or slurry	1.1 oz/cwt	D, WP, FlC 	NA	NA

	NA

	Seed treatment

Planter box	0.25 oz/cwt	D

Rutabaga

Seed treatment

Slurry	2.3 oz/cwt	WP,  FlC 	NA	NA	NA

	Seed treatment

Dust	3.4 oz/cwt	D

Rye

Seed treatment

Dust or slurry	1.5 oz/cwt	D, WP,  FlC	NA	NA	NA

	Seed treatment

Planter box	0.25 oz/cwt	D

Safflower

Seed treatment

Planter box	0.25 oz/cwt	D	NA	NA	NA

	Sesame

Seed treatment

Slurry

	0.8 oz/cwt	WP, FlC 	NA	NA	NA

	Sorghum - milo

Seed treatment

Slurry	3 oz/cwt	WP, FlC 	NA	NA	NA

Sorghum - hulled

Seed treatment

Dust or slurry	3 oz/cwt	D, WP, FlC	NA	NA	NA

	Soybeans

Seed treatment

Slurry	1.3 oz/cwt	WP, FlC 	NA	NA	NA

	Seed treatment

Dust	1.9 oz/cwt	D

Seed treatment

Planter box	1.75 oz/cwt	D

Spinach

Seed treatment

Slurry	3.3 oz/cwt	WP, FlC 	NA	NA	NA

	Seed treatment

Dust	4.5 oz/cwt	D

Seed treatment

Planter box	0.5 oz/cwt	D

Squash, pumpkins, watermelon

Seed treatment

Slurry	1 oz/cwt	WP, FlC 	NA	NA	NA

	Seed treatment

Dust	1.5 oz/cwt	D

Seed treatment

Planter box	0.5 oz/cwt	D

Strawberries

Foliar

Ground and aerial equipment	3 lb/A	WP, FlC, WDG	24 lb/A	7	0	U.S.

Chemigation permitted in SC under EPA SLN NO. SC920001

Sugar beets, Eastern U.S.

Seed treatment

Slurry	6 oz/cwt	WP, FlC	NA	NA	NA	Eastern U.S.

Sugar beets, Western U.S.

Seed treatment

Slurry	3 oz/cwt	WP, FlC	NA	NA	NA	Western U.S.

Sugar beets, unspecified

Seed treatment

Slurry	6 oz/cwt	WP, FlC 	NA	NA	NA

	Seed treatment

Dust	9 oz/cwt	D

Seed treatment

Planter box	2 oz/cwt	D

Sunflower

Seed treatment

Slurry	2 oz/cwt	FlC	NA	NA	NA

	Seed treatment

Planter box	0.5 oz/cwt	D

Swiss chard

Seed treatment

Slurry	6 oz/cwt	WP, FlC 	NA	NA	NA

	Seed treatment

Dust	9 oz/cwt	D

Turnips

Seed treatment

Slurry	1.5 oz/cwt	WP,  FlC 	NA	NA	NA

	Seed treatment

Dust	2.25 oz/cwt	D, WP,  FlC

Wheat

Seed treatment

Slurry	1 oz/cwt	WP

NA	NA

	Seed treatment

Dust or slurry	2 oz/cwt	FlC

Seed treatment

Planter box	0.8 oz/cwt	D

a	NA = Not applicable.

b	NS = Minimum interval between treatments not specified.

c  0.8 rate on EPA Reg. No. 10182-321

Table B.   Residue Chemistry Science Assessments for Reregistration of Captan.

GLN:  Data Requirements	Tolerances,

ppm [40 CFR]	Must Additional Data Be Submitted?

References1

	860.1200:  Directions for Use	N/A = Not Applicable

	Yes2

	860.1300:  Plant Metabolism	N/A	No	00058941 00083100 00096978 00098790 00098831 00128355 GS120-001 406580053 406580063 417460014 421096015

860.1300:  Animal Metabolism	N/A	No	00058940 00096901 00096908 00098786 00128355 GS120-003 GS120-004 406580023 406580033 406580043

425688017 427564018

432667016 432667026

860.1340:  Residue Analytical Methods	N/A	No9	00002927 00002928  00003025 00025123 00025125 00025129 00035246 00035248 00042645 00042646 00045174 00045175 00045176 00045179 00045182 00045183 00045184 00045188 00045189 00053324 00054015 00054016 00070201 00071790 00083393 00085525 00085526 00090988 00090989 00096910 00096982 00097622 00098720 00098726 00098731 00098747 00098751 00098784 00098789 00098804 00098810 00098811 00098817 00098818 00098894 00117087 00128355 GS120-008 GS120-011 413930013 413865013 414069013

860.1380:  Storage Stability	N/A	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4280390114

860.1500:  Magnitude of the Residue in Plants

	Root and Tuber Vegetables Group

	 - Beet roots	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER>

4130610117<PHONE_NUMBER><PHONE_NUMBER>

 - Carrots	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Potatoes	25 [§180.103 (b)]	No	00098716 00098894 00054016<PHONE_NUMBER> 4114910416<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

 - Rutabagas	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Taro	2 [§180.103 (a)]	No19<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610117<PHONE_NUMBER>

 - Turnip roots	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

Leaves of Root and Tuber Vegetables Group

	 - Beet greens	100 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER>   4130610117<PHONE_NUMBER><PHONE_NUMBER>

 - Turnip greens	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

Bulb Vegetables Group

	 - Garlic	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Leeks	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Onions, dry bulb	25 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER> 4130610117<PHONE_NUMBER><PHONE_NUMBER>

 - Onions, green	50 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Shallots	50 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

Leafy Vegetables Group

	 - Celery	50 [§180.103 (a)]	No	00070201<PHONE_NUMBER><PHONE_NUMBER> 4114910216<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

 - Lettuce	100 [§180.103 (a)]	No	00070201<PHONE_NUMBER><PHONE_NUMBER> 4114910216<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

 - Spinach	100 [§180.103 (a)]	No	00070201<PHONE_NUMBER><PHONE_NUMBER> 4114910216<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

Brassica Leafy Vegetables Group

	 - Broccoli	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Brussels sprouts	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER> 4130610117<PHONE_NUMBER><PHONE_NUMBER>

 - Cabbage	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Cauliflower	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Collards	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Kale	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4146840118

 - Mustard greens	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

Legume Vegetables Group

	 - Beans, dry	25 [§180.103 (b)]	No	00046914 00070201 00098710 4018982015<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

 - Beans, succulent	25 [§180.103 (b)]	No	00046914 00070201 00098710 4018982015<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

 - Peas, dry	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Peas, succulent	2 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Soybeans, dry	2 [§180.103 (a)]	No	00003025 00071790 00096982 4018982015<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

 - Soybeans, succulent	2 [§180.103 (a)]	No	00071790 00096982 00098709 4018982015<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

Fruiting Vegetables Group

	 - Eggplants	25 [§180.103 (a)]	No	00098709<PHONE_NUMBER><PHONE_NUMBER> 4130610117<PHONE_NUMBER><PHONE_NUMBER>

 - Peppers	25 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Pimentos	25 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Tomatoes	25 [§180.103 (a)]	No	00070201 00085526 00098708<PHONE_NUMBER> 4018982315<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

Cucurbit Vegetables Group

	 - Cantaloupes	25 [§180.103 (a)]	No	00098818<PHONE_NUMBER><PHONE_NUMBER> 4130610117<PHONE_NUMBER><PHONE_NUMBER>

 - Cucumbers	25 [§180.103 (a)]	No	00098709<PHONE_NUMBER><PHONE_NUMBER> 4130610117<PHONE_NUMBER><PHONE_NUMBER>

 - Honeydew melons	25 [§180.103 (a)]	No	00098818<PHONE_NUMBER><PHONE_NUMBER> 4130610117<PHONE_NUMBER><PHONE_NUMBER>

 - Muskmelons	25 [§180.103 (a)]	No	00098818<PHONE_NUMBER><PHONE_NUMBER> 4130610117<PHONE_NUMBER><PHONE_NUMBER>

 - Pumpkins	25 [§180.103 (a)]	No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4130610217<PHONE_NUMBER>

 - Squash, summer	25 [§180.103 (a)]	No	00098818<PHONE_NUMBER><PHONE_NUMBER> 4130610117<PHONE_NUMBER><PHONE_NUMBER>

 - Squash, winter	25 [§180.103 (a)]	No	00098818<PHONE_NUMBER><PHONE_NUMBER> 4130610117<PHONE_NUMBER><PHONE_NUMBER>

 - Watermelons	25 [§180.103 (a)]	No	00128355<PHONE_NUMBER><PHONE_NUMBER> 4130610117<PHONE_NUMBER><PHONE_NUMBER>

Pome Fruits Group

	 - Apples	25 [§180.103 (a)]	No	00085526 00098711 00098722 00098789 00106602 00128355<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

 - Pears	25 [§180.103 (a)]	No	00070201 00085526 00098722 00106602 00128355<PHONE_NUMBER>

Stone Fruits Group

	 - Apricots	50 [§180.103 (a)]	No	00128355<PHONE_NUMBER>

 - Cherries	100 [§180.103 (a)]	No	00128355<PHONE_NUMBER>

 - Nectarines	50 [§180.103 (a)]	No	00128355<PHONE_NUMBER>

 - Peaches	50 [§180.103 (a)]	No	00128355<PHONE_NUMBER><PHONE_NUMBER> 4074540721

 - Plums (fresh prunes)	100 [§180.103 (a)]	No	00128355<PHONE_NUMBER>

Small Fruits and Berries Group

	 - Blackberries	25 [§180.103 (a)]	 No22<PHONE_NUMBER>

 - Blueberries (huckleberries)	25 [§180.103 (a)]	No	00046914 00070201 00090988 00128355<PHONE_NUMBER>

 - Caneberry	25 [§180.103 (a)]	No	44227201 29

 - Dewberries	25 [§180.103 (a)]	  No22<PHONE_NUMBER>

 - Grapes	50 [§180.103 (a)]	No	00046914 00070201 00090988 00098726 00128355<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER> 4225420210

 - Raspberries	25 [§180.103 (a)]	 No22	00070201<PHONE_NUMBER>

 - Strawberries	25 [§180.103 (a)]	No	00046914 00070201 00090988 00117088 00128355<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

4348970125

Tree Nuts Group

	 - Almonds	2 [§180.103 (b)]	No	00070201 00090988 00098804 00098811 00128355<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

 - Almond hulls	100 [§180.103 (b)]	No	00070201 00090988 00098804 00098811 00128355<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

Cereal Grains Group

	 - Corn, sweet	2 [§180.103 (a)]	No	00003025 00045176 00070201 00128355 GS120-039<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

Miscellaneous Commodities

	 - Cottonseed	2 [§180.103 (a)]	No	00002928 00003025 00070201 00128355 GS120-039<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

	860.1520:  Magnitude of the Residue in Processed Food/Feed

	 - Apples

	No	00098789<PHONE_NUMBER>

4229600310<PHONE_NUMBER><PHONE_NUMBER>

 - Grapes	50 (Raisins) [§185.500]

	No26	00128355<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>

 - Plums/Prunes

No<PHONE_NUMBER>

860.1480:  Magnitude of the Residue in Meat, Milk, Poultry, and Eggs

	 - Cattle, hogs	0.05 (fat, meat, and mbyp)

[§180.103 (a)]

	No27	00025125 00035246 00035248 00045178 00096910 00098751 00098808 00098810 00104753<PHONE_NUMBER><PHONE_NUMBER>

171-5:  Reduction of Residues

No<PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER><PHONE_NUMBER>  0015960620<PHONE_NUMBER><PHONE_NUMBER>

860.1850:  Rotational Crops (Confined)

No<PHONE_NUMBER><PHONE_NUMBER>

860.1900:  Rotational Crops (Field)

No

1	These references were reviewed in the Residue Chemistry Science Chapter of the Reregistration Standard dated 3/6/86.  Otherwise, references were reviewed as noted.

2	The following labels must be revised to include a maximum annual use rate and pre-harvest interval: 66330-23 and -27.  The label must specify that the annual use rate includes any post-harvest sprays.  The directions for post-harvest dip for apples, cherries, and pears must be modified on label 66330-23.  The feeding restriction for almond hulls must be removed from 66330-23 because HED does not consider such a restriction to be practical.

3	CBRS Nos. 6525/6526, 10/2/90, R. Perfetti.

4	CBRS No. 7583, DP Barcode D160608, 9/11/91, R. Perfetti.

5	CBRS No. 9135, DP Barcode D172317, 4/15/92, P. Deschamp.

6	CBRS No. 14006, DP Barcode D205450, 11/30/94, C. Olinger.

7	CBRS No. 11262, DP Barcode D187280, 2/12/93, C. Olinger.

8	CBRS No. 11936, DP Barcode D191630, 2/17/94, C. Olinger.

9	Zeneca (formerly ICI) method No. 166 for quantifying THPI meat and milk is adequate for use in enforcement (CBRS No. 9877, DP Barcode D178079, 6/22/92, C. Olinger).

10	Sufficient storage stability data are available to support the residue data for milk.  THPI residues are stable in animal tissues for 3 years when results are corrected for concurrent method recoveries (D214345, D222419; C. Olinger, 5/30/96). No additional storage stability data are required for animal commodities.

11	CBRS No. 4204, 12/19/89, L. Propst.

12	CBRS No. 5148, 5/31/89, L. Cheng.

13	CBRS No. 6995, DP Barcode D155338, 6/26/91, C. Olinger.

14	CBRS No. 12183, DP Barcode D192936, 5/10/94, C. Olinger.

15	CBRS No. 2317, 4/22/88, N. Gray.

16	CBRS No. 5589, 10/6/89, C. Olinger.

17	CBRS No. 6142, 1/29/90, C. Olinger.

18	CBRS No. 6691, 7/30/90, C. Olinger.

19	CBRS No. 6055, 12/18/89, J. Smith.

20	CBRS No. 953, 7/21/86, L. Bradley.

21	CBRS No. 4203, 12/19/89, L. Propst.

22	CBRS No. 11071, DP Barcode No. D186008, 4/25/94, C. Olinger. Data from a minimum of two additional field trials were required for reregistration of captan on caneberry subgroup. Tolerance will be established for caneberry  and individual tolerances revoked (C. Olinger, CBRS No. 13214, DP Barcode D199377, 3/29/94). Data are available to support the establishment of a caneberry tolerance and revocation of individual tolerances (T. Morton, D234270, 3/16/99).

23	Data are available to support the 24C label (D. Davis, CBTS Nos. 11712/11716, DP Barcodes D190127 and D190128, 5/6/93; CBTS Nos. 11890/11891, DP Barcodes D191396 and D191398, 6/1/93); and CBTS Nos. 12097/12098, DP Barcodes D192518 and D192519, 6/29/93).

24	CBRS No. 1334, 9/16/86, L. Bradley.

25	CBRS No. 14715, 6/15/95, C. Olinger. No additional field trials are required to support the reregistration of strawberry. The tolerance can be reassessed at 25 ppm.

26	CBRS No. 16181, 11/14/95, C. Olinger.

27	Tolerance increases for animal products should be proposed for cattle, goats, sheep, horses and hogs:  meat, 0.20 ppm;  meat by-products, 0.30 ppm;  and fat, 0.15 ppm.  A tolerance for milk must be proposed at 0.10 ppm.  The tolerance for animal commodities should be expressed as captan and tetrahydrophthalimide, measured as tetrahydrophthalimide.

28	CBRS No. 13457, DP Barcode D201033, 7/26/94, S. Funk.

29	CBRS No. none, DP Barcode D234270, 3/16/99,  T. Morton.

TOLERANCE REASSESSMENT SUMMARY

Based on the metabolism data in plants and animals for captan, the HED Metabolism Committee (4/12/94 and 9/4/97) has determined that the tolerance expression for meat and milk should include both the parent, captan and the metabolite THPI.  The tolerance expression for plants, based on captan per se only, should remain unchanged.

Tolerances for plant and animal commodities currently listed in 40 CFR §180.103(a) are for residues of captan per se.  This tolerance definition is to be retained for plant commodities; a separate tolerance definition is appropriate for livestock commodities.  The tolerance expression for residues in livestock commodities should be "the combined residues of captan and its metabolite THPI...".  CBRS recommends that tolerances for livestock commodities be removed from 40 CFR §180.103(a) and placed in a new 40 CFR §180.103 © under the revised tolerance expression.

Tolerances are required to cover the seed treatment uses on the following crops for which there are currently no established tolerances:  alfalfa, barley (grain, forage, and straw), clover, corn (field), cotton forage, flax (seed and straw), grasses (forage and hay), lespedeza, oats (grain, forage, and straw), okra, peanuts and peanut hay, radish roots, radish tops, rape seed, rape forage, rape greens, rye (grain, forage, and straw), safflower, sesame, sunflower (seed and forage), sorghum (grain, forage and fodder), sugar beet roots, sugar beet tops, Swiss chard, trefoil, and wheat (grain, forage, and straw).

Adequate data are available to assess the established tolerances for captan residues in meat, fat, and meat byproducts of cattle and hogs.  The expression of these tolerances should be changed to "the combined residues of captan and its metabolite THPI..."  These tolerances should be deleted from 40 CFR §180.103(a) and placed in a separate section, 40 CFR §180.103(c).  Tolerances should be added to this section for milk and the meat, fat, and meat byproducts of goats, horses, and sheep.  HED recommends the following tolerance levels for cattle, goats, sheep, horses and hogs:  meat, 0.20 ppm; meat by-products, 0.30 ppm; fat, 0.15 ppm; and milk, 0.1 ppm.

Tolerances are not required for eggs and the meat, fat, and meat byproducts of poultry.

The established tolerances for residues of captan in/on avocados, celery, garlic, leeks, mangoes, shallots, and taro should be revoked as there are no registered uses of captan on these crops.

The individual tolerances for blackberry, dewberry, and raspberry should be revoked and a tolerance for the subgroup caneberry should be established at 25 ppm (D234270, 3/16/99,  T. Morton).

Tolerances listed in 40 CFR §180.103(b) are for residues of captan per se and are established on an interim basis.  HED recommends that tolerances listed in 40 CFR §180.103(b) for almonds, almond hulls, beans dry, beans succulent, and potatoes be moved to 40 CFR §180.103(a) at their respective reassessed tolerance levels.

The food additive tolerance listed in 40 CFR §185.500 for washed raisins is for residues of captan per se.  Captan does not concentrate in washed raisins so therefore, the tolerance should be revoked.  HED had previously recommended for revocation of the raisin tolerance in  40 CFR §185.500 (C. Olinger; 11/14/95; D219159).

Table C.  Tolerance Reassessment Summary for Captan

Commodity	Current Tolerance

(ppm)	Tolerance

Reassessment (ppm)	Comment/Correct Commodity Definition

Tolerances listed under 40 CFR §180.103 (a)

	Apples	25	25

	Apricots	50	10

	Avocados	25	Revoke	No registered uses exist

Beet, greens	100	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Beet (roots)	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Blackberry

	25

	Revoke	Tolerance to be established for caneberry

Blueberries (huckleberries)	25	40

	Broccoli	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Brussels sprouts	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Cabbage	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Caneberry

25	Tolerance will be established for crop group in 40 CFR §180.103  (a)

Cantaloupes	25	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Carrots	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Cattle, fat

Cattle meat

Cattle, mbyp	0.05

0.05

0.05	0.15

0.20

0.30	Move to 40 CFR §180.103  (c)

Cauliflower	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Celery	50	Revoke	No registered uses exist

Cherries	100	50

	Collards	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Corn, sweet (K+  CWHR)	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Cottonseed	2	0.05	Move to 40 CFR §180.103(b)/Cotton, seed

Cucumbers	25	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Dewberry	25	Revoke	Tolerance to be established for caneberry

Eggplants	25	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Garlic	25	Revoke	No registered uses exist

Grapes	50	25

	Hogs, fat

Hogs, meat

Hogs, mbyp	0.05

0.05

0.05	0.15

0.20

0.30	Move to 40 CFR §180.103 (c)

Honeydew melons	25	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Kale	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Leeks	50	Revoke	No registered uses exist

Lettuce	100	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Mangoes	50	Revoke	No data have been submitted to support use

Muskmelons	25	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Mustard greens	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Nectarines	50	25

	Onions, dry bulb	25	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Onions, green	50	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Peaches	50	15

	Pears	25	25

	Peas, dry	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Peas, succulent	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Plums (fresh prunes)	100	10

	Peppers

Pimentos	25

25	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Pumpkins	25	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Raspberry	25	Revoke	Tolerance to be established for caneberry

Rutabagas (roots)	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Shallots	50	Revoke	No registered uses exist

Soybeans, dry	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Soybeans, succulent	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Spinach	100	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Squash, summer	25	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Squash, winter	25	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Strawberries	25	25

	Taro (corn)	0.25	Revoke	No registered uses exist

Tomatoes	25	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Turnip, greens	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Turnips, roots	2	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Watermelons	25	Revoke	Tolerance will be established for crop group in 40 CFR §180.103  (b)

Tolerances listed under 40 CFR §180.103 (b)

	Almonds	2	0.25	Move to

40 CFR §180.103 (a)

Almond hulls	100	75	Move to

40 CFR §180.103 (a)

Beans, dry	25	Revoke	Tolerance will be established for crop group

Beans, succulent	25	Revoke	Tolerance will be established for crop group

Potatoes	25	Revoke	Tolerance will be established for crop group

Tolerances required under 40 CFR §180.103 (b) - Redefined

	Brassica Leafy Vegetables	--	0.05	Seed treatment only

Bulb Vegetables	--	0.05	Seed treatment only

Cereal Grains	--	0.05	Seed treatment only

Cereal Grain Forage, Fodder, and Straw	--	0.05	Seed treatment only

Cucurbit Vegetables	--	0.05	Seed treatment only

Dill, seed	--	0.05	Seed treatment only

Foliage of Legume Vegetables	--	0.05	Seed treatment only

Flax, seed	--	0.05	Seed treatment only

Flax, straw	--	0.05	Seed treatment only

Fruiting Vegetables	--	0.05	Seed treatment only

Grasses (Forage and Hay)	--	0.05	Seed treatment only

Leafy Vegetables (except Brassica)	--	0.05	Seed treatment only

Leaves of Root and Tuber Vegetables	--	0.05	Seed treatment only

Legume Vegetables (succulent and dried)	--	0.05	Seed treatment only

Non-Grass Animal Feeds (Forage, Fodder, Straw, and Hay)	--	0.05	Seed treatment only

Okra	--	0.05	Seed treatment only

Peanuts	--	0.05	Seed treatment only

Peanut hay	--	0.05	Seed treatment only

Rape, seed	--	0.05	Seed treatment only

Rape, forage	--	0.05	Seed treatment only

Rape, greens	--	0.05	Seed treatment only

Root and Tuber Vegetables	-	0.05	Seed treatment only

Safflower seed	--	0.05	Seed treatment only

Sesame seed	--	0.05	Seed treatment only

Sunflower, seeds	--	0.05	Seed treatment only

Sunflower, forage	--	0.05	Seed treatment only

Tolerances required under 40 CFR §180.103 (c)

	Cattle, fat	0.05	0.15

	Cattle, mbyp 	0.05	0.30

	Cattle, meat	0.05	0.20

	Goats, fat	--	0.15

	Goats, mbyp	--	0.30

	Goats, meat	--	0.20

	Hogs, fat	0.05	0.15

	Hogs, mbyp	0.05	0.30

	Hogs, meat	0.05	0.20

	Horses, fat	--	0.15

	Horses, mbyp	--	0.30

	Horses, meat	--	0.20

	Milk	--	0.10

	Sheep, fat	--	0.15

	Sheep, mbyp	--	0.30

	Sheep, meat	--	0.20

Food Additive Tolerances Listed Under 40 CFR §185.500

	Washed raisins	50	Revoke	No concentration in washed raisins.

Refer to Table C for modifications in commodity definitions and recommended tolerance revisions and Table D for recommendations for harmonizing U.S. tolerances with Codex MRLs.

	●	The established tolerance levels for apple, pear, and strawberry are adequate and should remain.

	●	The established tolerances for almonds, almond hulls, apricots, cherries, grapes, nectarines, peaches, and plums can be lowered due to revised, more restrictive use patterns.

	●	The established tolerances for beans (dry), beans (succulent), beet greens, beet roots, cantaloupes, cucumbers, eggplants, honeydew melons, kale, lettuce, muskmelons, onions, peas (dry), peas (succulent), peppers, pimentos, pumpkins, spinach, squash (summer), squash (winter), and watermelons should be lowered to 0.05 ppm.  All uses except seed treatments on these crops have been canceled.  The recommended 0.05 ppm level represents nondetectable residues of captan.

●	The established 2 ppm tolerances for captan residues in/on broccoli, Brussels sprouts, cabbage, carrots, cauliflower, collards, corn (sweet, K+CWHR), cottonseed, mustard greens, rutabagas, soybeans (dry), soybeans (succulent), turnip tops, and turnip roots from seed treatment use should be lowered to 0.05 ppm to represent nondetectable captan residues.

	●	The established tolerance levels for blueberry of 25 ppm should be increased to 40 ppm based on registered use patterns in the U.S.

CODEX HARMONIZATION

Several maximum residue limits (MRLs) for captan have been established by Codex in various commodities.  The captan residues regulated by Codex and the U.S. are equivalent.  The Codex MRLs defined in terms of captan per se and corresponding U.S. tolerances are listed in Table D.

Table D.	Codex MRLs and applicable U.S. tolerances.  Recommendations for compatibility are based on conclusions following reassessments of U.S. tolerances (see Table C).

Commodity	MRL (mg/kg)1	U.S. Tolerance (ppm)	Recommendation

Apple	25	25

	Blueberries	20	40

	Citrus fruits	152	N/A

	Dried grapes	52	50

 (washed raisins)	Previous recommendation for revocation for washed raisin tolerance

Peach	15	50	Decrease U.S. tolerance

Pear	25	25

	Strawberry	20	25

	Tomato	15	0.05	U.S. tolerance to be revoked; tolerance to be established for Fruiting Vegetables/Seed Treatment only

	1All captan MRLs are final (CXL).

2JMPR 1990 had proposed to withdraw the CXL in view of no expected uses.

The following conclusions can be made regarding efforts to harmonize the U.S. tolerances with the Codex MRLs:

	○	Compatibility between U.S. tolerances and Codex MRLs exists for apples and pears.

	○	The level of the U.S. tolerances should be decreased to achieve compatibility with the Codex MRLs for peaches (from 25 ppm to 15 ppm).  The available residue data support the decreased tolerance levels.

	○	HED had previously recommended for revocation of the raisin tolerance in  40 CFR §185.500 (C. Olinger; 11/14/95; D219159).  The tolerance cannot be lowered to 5 ppm to achieve compatibility with the Codex MRL for dried grapes.

	○	The U.S. tolerance of 25 ppm for strawberries is based on registered use patterns in the U.S. and cannot be lowered to 20 ppm to achieve compatibility with the Codex MRL of 20 ppm.

	○	The U.S. reassessed tolerance of 40 ppm for blueberries is based on registered use patterns in the U.S. and cannot be lowered to 20 ppm to achieve compatibility with the Codex MRL of 20 ppm.

	○	No questions of compatibility exist with respect to  commodities where:  (I) no Codex MRLs have been established but U.S. tolerances exist; or (ii) Codex MRLs have been established but U.S. tolerances do not exist.

DIETARY EXPOSURE REASSESSMENT tc "DIETARY EXPOSURE REASSESSMENT"

The plant metabolism data for captan are adequate.  Sufficient residue data are available to reassess all tolerances for plant commodities with the exception of the caneberries (blackberries, dewberries, and raspberries) and strawberries.  The existing data are sufficient to estimate that the tolerances for these commodities are not likely to require modification.

Tolerances are not required for poultry commodities.

HED has revised the anticipated residue calculations for captan and THPI in light of canceled uses, recently submitted residue data, and the most recent FDA monitoring data.  The risk assessment will involve captan only for raw plant and processed plant commodities and captan and THPI for meat and milk.  Captan and THPI residues in livestock feed items will be considered when estimating the livestock dietary burden.

The anticipated residue values are the best estimates HED can provide using the residue data available at the time of the RED.  These values have an inherent uncertainty associated with the variations in analytical methods, geographical representation of field trials, seasonal variation of residue levels, and other factors.

AGENCY MEMORANDA CITED IN THIS DOCUMENT tc "AGENCY MEMORANDA CITED IN THIS DOCUMENT"

CBRS No.:	953

Subject:		Captan Residue Reduction Data Submitted in Response to 04/29/85 DCI Letter.  Accession No. 262770.  RCB No. 953

From:		L.M. Bradley

To:		C. Langley, A. Rispin, E. Wilson, and B. Briscoe

Dated:		7/21/86

MRID(s):	00159595-00159608

CBRS No.:	1334

Subject:		Captan.  Addendum to Residue Reduction Data Submitted in Response to 04/29/85 DCI Letter.  Accession No. 263843.  RCB No. 1334.

From:		L.M. Bradley

To:		C. Monroe, A. Rispin, E. Wilson, and B. Briscoe

Dated:		9/19/86

MRID(s):	00162037

CBRS No.:	2317

Subject:		Captan - Addendum to Registration Standard.  RCB No. 2317.  MRID Nos. 401898-02 through - 24 and 400105-01.

From:		N.S. Gray

To:		J. Dizikes and E. Wilson

Dated:		4/22/88

MRID(s):	40010501 and 40189802-40189824

CBRS No.:	4203

Subject:		Residue Data Reflecting Aerial Versus Ground Spray Applications of Captan on Foliar Crops

From:		L.S. Propst

To:		E.M. Wilson

Dated:		12/19/89

MRID(s):	40475401-40745409

CBRS No.:	4204

Subject:		Captan - Storage Stability Studies for the Captan Registration Standard

From:		L.S. Propst

To:		E.M. Wilson

Dated:		12/19/89

MRID(s):	40752301

CBRS No.:	5148

Subject:		239-1246.  Captan on Blueberries.  MRID # 410391-01.  DEB # 5148.

From:		L. Cheng

To:		R. Mountfort

Dated:		5/31/89

MRID(s):	41039101

CBRS No.:	5589

Subject:		Residue Data Review for Corn, Soybean, Beet, and Spinach Seed Treatments with Captan, DEB No. 5589, EPA No. 239-1246, MRID Nos. 411491-01 through -04

From:		C.L. Olinger

To:		E. Wilson

Dated:		10/6/89

MRID(s):	41149101-41149104

CBRS No.:	6142

Subject:		Residue Data Review for Soybean and Wheat Seed Treatments with Captan, Record No. 256461;  ID No. 10182-293; DEB No. 6142; MRID Nos. 413061-01 and -02

From:		C.L. Olinger

To:		J. Miller

Dated:		1/29/90

MRID(s):	41306101 and 41306102

CBRS No.:	6691

Subject:		Addendum to Residue Data for Captan Seed Treatments; EPA Reg. No. 10182-293; MRID No. 41468401; DEB No. 6691

From:		C.L. Olinger

To:		J. Miller

Dated:		7/30/90

MRID(s):	41468401

CBRS Nos.:	6525 and 6526

Subject:		Chevron Chemical Co.: Response to the Captan Reregistration Standard: Residue Chemistry Requirements (No MRID #'s 406580-02, -03, -04, -05, and -06, and 413930-01, 414069-01, 413865-01, DEB #'s 6525 and 6526.)

From:		R.B. Perfetti

To:		R. Engler and L. Rossi

Dated:		10/2/90

MRID(s):	40658002-40658006, 41386501, 41393001, and 41406901

CBRS No:	6995

DP Barcode:	D155338

Subject:		Captan - Storage Stability Studies for the Captan Registration Standard and Follow-Up to Seed Treatment Residue Data; MRID No. 411576-01; Branch No. 6995; DP Barcode No. 155338

From:		C.L. Olinger

To:		C. Peterson

Dated:		6/26/91

MRID(s):	41157601

CBRS No.:	7583

DP Barcode:	D160608

Subject:		Captan - Registrant's Response to Residue Chemistry Data Requirements

From:		R. Perfetti

To:		R. Engler and L. Rossi

Dated:		6/26/91

MRID(s):	41746001

CBRS No.	9135

DP Barcode:	D172317

Subject:		Reregistration of Captan.  Case No. 120.  Qualitative Nature of the Residue in Plants

From:		P. Deschamp

To:		L. Rossi/C. Peterson

Dated:		4/15/92

MRID(s):	42109601

CBRS No.	9902, 10668, and 11105

DP Barcode:	D178351 and D183051

Subject:		Reregistration of Captan:  Magnitude of Residue in Meat, Milk, Poultry, and Eggs;  Magnitude of Residue in Apples, Grapes, and their Processed Products

From:		C. Olinger

To:		L. Rossi

Dated:		5/20/94

MRID(s):	42252201, 42252202, 42296001, 42296002, 42296003, 42296004, 42563101 and 42563102

CBRS No.	9877

DP Barcode:	D178079

Subject:		Reregistration of Captan:  Method Validation Request

From:		C. Olinger

To:		D. Marlow

Dated:		6/22/92

MRID(s):	None

CBRS No.	10477

DP Barcode:	D182080

Subject:		Reregistration of Captan:  Use on Strawberries

From:		C. Olinger

To:		L. Rossi

Dated:		9/16/92

MRID(s):	None

CBRS No.	11071

DP Barcode:	D186008

Subject:		Reregistration of Captan:  Use on Peaches and Nectarines

From:		C. Olinger

To:		L. Rossi

Dated:		4/25/94

MRID(s):	None

CBRS No.	11262

DP Barcode:	D187280

Subject:		Reregistration of Captan:  Animal Metabolism Study Interim Report

From:		C. Olinger

To:		L. Rossi

Dated:		2/12/93

MRID(s):	42568801

CBTS No.	11712/11716

DP Barcode:	D190127/D190128

Subject:		WA920011, WA920012, Section 24© Captan on Raspberries and Blackberries

From:		D. Davis

To:		D. Kenney/Joanne Miller

Dated:		5/6/93

MRID(s):	42712801

CBTS No.	11890/11891

DP Barcode:	D191396/D191398

Subject:		WA920011, WA920012, Section 24© Captan on Raspberries and Blackberries

From:		D. Davis

To:		D. Kenney/Joanne Miller

Dated:		6/1/93

MRID(s):	42712801

CBTS No.	12097/12098

DP Barcode:	D192518/D192519

Subject:		WA920011, WA920012, Section 24© Captan on Raspberries and Blackberries

From:		D. Davis

To:		D. Kenney/Joanne Miller

Dated:		6/29/93

MRID(s):	42712801

CBRS No.	11936

DP Barcode:	D191630

Subject:		Reregistration of Captan:  Metabolism in Laying Hens

From:		C. Olinger

To:		L. Rossi

Dated:		2/17/93

MRID(s):	42756401

CBRS No.	13214

DP Barcode:	D199377

Subject:		Reregistration of Captan:  Raspberry Magnitude of Residue Data

From:		C. Olinger

To:		L. Rossi

Dated:		3/29/94

MRID(s):	43086601

CBRS No.	12183

DP Barcode:	D192936

Subject:		Reregistration of Captan:  Storage Stability Issues

From:		C. Olinger

To:		L. Rossi

Dated:		5/10/94

MRID(s):	42803901

CBRS No.	13650

DP Barcode:	D202998

Subject:		Use of Captan on Strawberries

From:		C. Olinger

To:		J. Miller

Dated:		5/20/94

MRID(s):	None

CBRS No.	None

DP Barcode:	None

Subject:		The Metabolism Committee Meetings Held on February 22 and March 1, 1994; Captan Plant and Animal Metabolism

From:		C. Olinger

To:		The Metabolism Committee; Health Effects Division

Dated:		4/1/94

MRID(s):	None

CBRS No.	14006

DP Barcode:	D205450

Subject:		Addendum to Captan RED: Captan Livestock Metabolism

From:		C. Olinger

To:		Linda Propst

Dated:		11/30/94

MRID(s):	43266701, 43266702

CBRS No.	15460, 17247

DP Barcode:	D214345, D222419

Subject:		Addendum to Captan RED: Registrant Rebuttal and Response to Previous Reviews

From:		C. Olinger

To:		Paula Deschamp

Dated:		5/30/96

MRID(s):	43584601, 43875603

CBRS No.	17426

DP Barcode:	D228077

Subject:		Addendum to Captan RED: Revisions to Table A of the Residue Chemistry Chapter

From:		C. Olinger

To:		John Redden

Dated:		2/5/97

MRID(s):	None

CBRS No.	None

DP Barcode:	D234270

Subject:		Reregistration of Captan: Use of Captan on Raspberries

From:		T. Morton

To:		K. Rothwell

Dated:		3/16/99

MRID(s):	44227201

MASTER RECORD IDENTIFICATION NUMBERS tc "MASTER RECORD IDENTIFICATION NUMBERS"

00002927 Devine, J.M.; Horton, W.E. (1972) Determination of Captan [N-Trichloromethylmercapto-4-cyclohexene-1,2,-dicarboximide] in Cottonseed: Report No. 120.  (Unpublished study received on unknown date under 0F0939; prepared by State Univ. College-Oswego, Lake Ontario Environmental Laboratory, submitted by Uniroyal Chemical, Bethany, Conn.; CDL:094582-A)

00002928 Uniroyal Chemical (1972) Residues in PPM: [Vitavax].  (Unpublished study received on unknown date under 0F0939; CDL:094582-B)

00003025 Chevron Chemical Company (1977) Residue Chemistry Data to Support the Label Registration of Orthocide-Vitavax 20-20 Seed Protectant.  Includes method RM-IF-1 dated Jun 25, 1976 entitled: Determination of Captan residues in crops.  (Unpublished study received May 11, 1977 under 239-2458; CDL:230222-A)

00025123 Chevron Chemical Company (1979) Determination of Captafol, Captan, THPI, and 3-OH THPI in Tissues and Eggs and Determination of Captan, THPI, 3-OH THPI, and 5-OH THPI in Milk and Cream.  Undated method nos. RM-6-G-2, RM-1G-1 and RRC-75-32.  (Unpublished study received Jan 2, 1980 under 239-2211; prepared in cooperation with Stauffer Chemical Co.; CDL:099190-F)

00025125 Leary, J.B.; Lai, J.C. (1976) Captan-Lactating Dairy Cow Feeding Study-Residues in Meat.  (Unpublished study received Jan 2, 1980 under 239-2211; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:099190-H)

00025129 Cheng, H.M. (1976) Metabolism of Carbonyl-14C-difolatan in Young Tomato and Corn Plants.  (Unpublished study received Jan 2, 1980 under 239-2211; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:099190-L)

00035246 Haumschild, D.; Wingender, R.J. (1972) Report to American Seed Trade Association, Inc.: Tissue Residue Study for Captan and Tetrahydrophthalimide in Crossbred Steers Fed Technical Captan:  IBT No. J1255.  Includes methods entitled: Determination of Captan and Determination of Tetrahydrophthalimide (THPI).  (Unpublished study received Jun 27, 1977 under 3E1367; prepared by Industrial Bio-Test Laboratories, Inc., submitted by Stauffer

00035248 Taylor, R.E.; Brunhouse, E. (1972) Captan Study for American Seed Trade Association.  Includes method RM-1E dated May 26, 1972.  (Unpublished study including letter dated Feb 1, 1973 from J.C. Calandra to Ron Harris, received Jun 27, 1977 under 3E1367; prepared by Harris Laboratories, Inc., submitted by Stauffer Chemical Co., Richmond, Calif.; CDL:096174-D)

00042645 Rappaport, S.H.; Katague, D.B. (1978) Determination of Captan Residues in Crops by Gas Chromatography.  Method RRC-76-30R dated Mar 27, 1978.  (Unpublished study received Sep 25, 1980 under 0E2427; prepared by Stauffer Chemical Co., submitted by New Zealand, Ministry of Agriculture and Fisheries, Wellington, New Zealand; CDL:099651-C)

00042646 New Zealand, Ministry of Agriculture and Fisheries (19??) Method for the Determination of Captan Residues in Kiwifruit.  (Unpublished study; CDL:099651-D)

00045174 Haumschild, D.; Wingender, R.J. (1972) Report to American Seed Trade Association, Inc.: Tissue Residue Study for Captan and Tetrahydrophthalimide in Crossbred Steers Fed Technical Captan:  IBT No. J1255.  Includes undated methods entitled: Determination of Captan and Determination of Tetrahydrophthalimide (THPI).  Prepared by Industrial Bio-Test Laboratories, Inc.  Unpublished study; 142 p.

00045175 American Seed Trade Association, Incorporated (19??) Analytical Method Used for Residue Analysis of Captan.  (Unpublished study received Mar 9, 1967 under 3E1367; CDL:096507-B)

00045176 Wilson, M. (1973) Captan Residue Report: Field Corn Seed.  (Unpublished study received on unknown date under 3E1367; submitted by American Seed Trade Association, Inc., Kalamazoo, Mich.; CDL:096507-C)

00045178 American Seed Trade Association, Incorporated (1973) Supplement to American Seed Trade Association, Inc. Petition #3F1367 for a Captan Tolerance on Detreated Corn Seed Intended as Feed for Beef Cattle and Swine.  (Unpublished study including letter dated Apr 25, 1973 from J.C. McKay to Harold Wright, received on unknown date under 3E1367; CDL:096507-E)

00045179 Patchett, G.G. (1973) Determination of Tetrahydrophthalamic acid Residues in Cattle and Hog Tissues.  Method no. WRC 73-38 dated May 17, 1973.  (Unpublished study received on unknown date under 3E1367; prepared by Stauffer Chemical Co., submitted by American Seed Trade Association, Inc., Kalamazoo, Mich.; CDL:096507-F)

00045182 American Seed Trade Association, Incorporated (19??) Determination of Captan Residues on Treated Seed Corn.  Undated method.  (Unpublished study received Mar 9, 1967 under 3E1367; CDL:096507-J)

00045183 American Seed Trade Association, Incorporated (19??) Method for Determination of Captan Residue on Corn.  (Unpublished study received Mar 9, 1967 under 3E1367; CDL:096507-K)

00045184 Kilgore, W.W.; Winterlin, W.; White, R. (1967) Gas chromatographic determination of Captan residues.  Journal of Agricultural and Food Chemistry 15(6):1035-1037.  (Also unpublished submission received on unknown date under 3E1367; submitted by American Seed Trade Association, Inc., Kalamazoo, Mich.; CDL:096507-L)

00045188 Chevron Chemical Company (1972) Determination of Captan Residues in Animal Tissues.  Method RM-1E dated May 26, 1972.  (Unpublished study received on unknown date under 3E1367; submitted by American Seed Trade Association, Inc., Kalamazoo, Mich.; CDL:096507-Q)

00045189 Wingender, R.J. (1973) Report to American Seed Trade Association, Inc.:  Results from the Analysis of Hog Tissues for Tetrahydrophthalimide: IBT No. D2043.  (Unpublished study received Mar 9, 1973 under 3E1367; prepared by Industrial Bio-Test Laboratories, Inc., submitted by American Seed Trade Association, Inc., Kalamazoo, Mich.; CDL:096506-F)

00046914 Hensall, GS (1957) Fulton Research Report 1957.  (Unpublished study received Oct 28, 1957 under unknown admin. no.; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:119324-A)

00053324 California Spray-Chemical Corporation (1957) Methods of Residue Analysis of Captan or Fulton.  (Unpublished study received Feb 11, 1958 under unknown admin. no.; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:119325-A)

00054015 California Spray Chemical Corporation (1960) The Analysis of Residues of Captan and Fulton.  Method RM-1 dated Apr 4, 1960.  (Unpublished study received Jul 14, 1972 under 2E1215; submitted by Interregional Research Project No. 4, New Brunswick, N.J.; CDL:091043-A)

00054016 University of Hawaii (1969) Captan-Taro Residue Study.  (Unpublished study received Jul 14, 1972 under 2E1215; prepared by Agricultural Biochemistry Dept., Pesticide Laboratory in cooperation with Chevron Chemical Co., submitted by Interregional Research Project No. 4, New Brunswick, N.J.; CDL:091043-B)

00058940 Cheng, H.M. (1980) Metabolism of [Carbonyl-14C]-Captan in a Lactating Goat: File No. 721.14/Captan.  (Unpublished study received Oct 30, 1980 under 239-533; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:243629-B)

00058941 Cheng, H.M. (1980) Degradation Products of [Carbonyl-14C]-Captan in Apple and Orange Processed Parts: File No. 721.14/Captan.  (Unpublished study received Oct 30, 1980 under 239-533; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:243629-D)

00070201 California Spray Chemical Corporation (1957) [Captan Residues-Various Crops].  (Reports by various sources; unpublished study received Feb 25, 1957 under PP0124; CDL:090426-J)

00071790 Stauffer Chemical Company (1980) [Residue Data of Various Chemicals, Including Captan, on Soybeans].  (Compilation; unpublished study received Dec 12, 1980 under AR 80/24; submitted by state of Arkansas for Stauffer; CDL:243877-A)

00083100 Pack, DE (1980) Analysis of Soybeans Grown from Seed Treated with 14C-Captan-Greenhouse Study: File 721.14.  (Unpublished study received Mar 23, 1981 under 239-2457; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:244766-A)

00083393 California Chemical Company (1961) The Determination of and Differentiation between Residues of Fulton and Captan:  File 740.10.  Residue method RM-1A dated Jan 31, 1961.  (Unpublished study received on unknown date under PP0283; CDL:090305-D)

00085525 Petri no, LM (1955) Colorimetric Estimation of Captan Surface Residue on Fruit Samples: (Adaptation of Method Published in Analytical Chemistry, July, 1952, Page 1173).  Method dated Mar 21, 1955.  (Unpublished study received May 1, 1955 under PP0015; prepared by Stauffer Chemical Co., submitted by California Spray-Chemical Co., Richmond, Calif.; CDL:090983-O)

00085526 California Spray-Chemical Company (1954) Determination of Captan Residues.  (Unpublished study received May 1, 1955 under PP0015; CDL:090983-P)

00090988 California Spray-Chemical Corporation (1957) The Results of Tests on the Amount of Residue Remaining, Including a Description of the Analytical Method Used:  [Captan].  (Compilation; unpublished study received on unknown date under PP0124; CDL:090432-D)

00090989 Curtis & Tompkins, Limited (1955) Letter sent to LW Hazleton dated Mar 30, 1955: Determination of captan and tetrahydrophthalimide residues on apples, concerning lab. no. 55d40.  (Incomplete; unpublished study received Apr 18, 1957 under PP0124; submitted by California Spray-Chemical Corp., Richmond, Calif.; CDL:090432-E)

00096901 Crassly, J. (1970) The Fate of Defoliation in a Lactating Ruminant (Goat): File No. 721.14.  (Unpublished study received Jun 9,1977 under 239-2211; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:096157-C)

00096908 Cheng, H.M. (1979) Metabolism of Carbonyl 14C Captafol in a Lactating Goat: File No. 721.14.  (Unpublished study received Jan 2, 1980 under 239-2211; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:099191-G)

00096910 Hillebrecht, W.R.; Riggs, R.L. (1977) Captan Milk Residue Study in Lactating Dairy Cattle.  (Unpublished study received Jan 2, 1980 under 239-2211; prepared by Stauffer Chemical Co., submitted by Chevron Chemical Co., Richmond, Calif.; CDL:099191-I)

00096978 Abell, J.; Moore, J.E. (1967) Attempts To Demonstrate the Translocation of Defoliation and Orthocide:  File No. 721.13.  (Unpublished study received May 30, 1978 under 239-2211; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:234046-AB)

00096982 Chevron Chemical Company (1979) Residue Data Sheet: [Soybeans]:  Test No. T-4546.  (Compilation; unpublished study received Mar 28, 1979 under 239-2369; CDL:237912-A)

00097622 Stauffer Chemical Company (1976) Captan 80-WP on Soybeans: Summary of Crop Residue Data.  (Compilation; unpublished study received 1976 under 476-EX-77; CDL:228997-A)

00098708 Chevron Chemical Company (1950) [Residue Studies of Orthocide 406 on Tomatoes].  (Compilation; unpublished study received Mar 21, 1951 under 239-533; CDL:001157-B)

00098709 Chevron Chemical Company (1950) [Residue Studies of Orthocide 406 on Various Vegetables].  (Compilation; unpublished study received Mar 21, 1951 under 239-533; CDL:001157-C)

00098710 Davis, D.L. (1950) Residue Analysis-SR-406: [Snap Beans].  (Unpublished study received Mar 21, 1951 under 239-533; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:001157-D)

00098711 Davis, D.L. (1950) Residue Analysis--SR-406: [Apples].  (Unpublished study received Mar 21, 1951 under 239-533; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:001157-E)

00098716 Kohn; G.K. (1954) Captan Residues on Potatoes.  (Unpublished study received Jun 2, 1954 under 239-533; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:001163-A)

00098720 Chevron Chemical Company (1952) Analysis of Fruits and Vegetables for Captan Residues.  (Unpublished study received Mar 22, 1955 under 239-533; CDL:001177-A)

00098722 Kohn, G.K. (1958) Letter sent to GS Hensall dated May 21, 1958:  Captan residues: postharvest treatment.  (Unpublished study received Jun 20, 1958 under 239-533; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:001194-A)

00098726 Chevron Chemical Company (1950) [SR-406: Residues in Various Crops].  (Compilation; unpublished study received Oct 10, 1951 under 239-1102; CDL:001257-B)

00098731 Kittleson, A.R. (1952) Colorimetric determination of N-trichloro-methiotetrahydrophthalimide.  Analytical Chemistry 24:1173-1174.  (Also unpublished submission received Feb 21, 1973 under 1486-20; submitted by Ferro Corp., Bedford, Ohio; CDL:006427-C)

00098747 Makhteshim Chemical Works Limited (1969) Merpan: Residue Analysis:  DS 13.51.11.  (Unpublished study received Apr 17, 1972 under 11678-1; CDL:026318-B)

00098751 Chevron Chemical Company (1954) Captan Residues in Meat.  (Unpublished study received May 5, 1954 under 239-656; CDL:027009-B)

00098784 Interregional Research Project Number 4 (1976) [Determination of Captan Pesticide in or on Taro Leaves].  (Compilation; unpublished study received Jul 11, 1977 under 7E1982; CDL:097592-A)

00098786 Mitoma, C. (1972) Pilot Study to Determine the Nature and Magnitude of the Residues from Ingestion of Captan in a Ruminating Animal:  SRI Project LSC-1697.  (Unpublished study received Mar 7, 1977 under 239-2457; prepared by Stanford Research Institute, submitted by Chevron Chemical Co., Richmond, Calif.; CDL:096129-B)

00098789 Chevron Chemical Company (1976) [Captan Residue Analyses-Apples].  (Compilation; unpublished study, including test nos. T-3513 and T-3514, received Mar 7, 1977 under 239-2457; CDL:096129-H)

00098790 DeBaun, J.R.; Gruwell, L.A.; Menn, J.J. (1975) The Fate of Captan [Carbonyl-14C] on Field-grown Apple Trees:  MRC-B-44.  Rev.  (Unpublished study received Mar 7, 1977 under 239-2457; prepared by Stauffer Chemical Co., submitted by Chevron Chemical Co., Richmond, Calif.; CDL:096129-I)

00098804 California Spray-Chemical Corporation (1961) Residue Data Sheet:  [Almonds]: Test No. T-239.  (Unpublished study received Jan 24, 1962 under 239-533; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:121209-A)

00098808 Chevron Chemical Company (1957) [Captan: Residues in Cattle].  (Compilation; unpublished study, including cattle progress report 247, received May 9, 1961 under unknown admin. no.; CDL:121212-C)

00098810 Cripps, J.M. (1957) Letter sent to California Spray-Chemical Corporation dated Feb 13, 1957: Captan residues-chicken eggs, breasts, thighs and livers.  (Unpublished study received May 9, 1961 under unknown admin. no.; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:121212-G)

00098811 Chevron Chemical Company (1957) [Captan Residues in Almonds].  (Compilation; unpublished study received May 9, 1961 under unknown admin. no.; CDL:121212-H)

00098817 Chevron Chemical Company (1957) [Residue Studies of Captan on Raisins].  (Compilation; unpublished study received Jun 25, 1957 under 239-104; CDL:121282-A)

00098818 Pennwalt Corporation (19??) Captan Residue on Cantaloupes Treated with Decco Salt No. 10.  (Unpublished study received Aug 5, 1957 under unknown admin. no.; CDL:121594-A)

00098831 Tagawa, H.; Yamaguchi, Y. (1970) Persistence of Captan and Defoliation in Soil and Their Absorption by Tobacco Plants from Soil.  A translation of:  [Without Title].  Bulletin of the Hatano Tobacco Experiment Station, Yokohama, Kangagwa, Japan 73:353.  (Unpublished study received Jan 4, 1978 under 239-1246; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:232569-H).

00098894 Chevron Chemical Company (1979) [Analyses for Orthocide Plus in Potatoes].  (Compilation; unpublished study received Sep 18, 1979 under 239-2474; CDL:241047-A)

00104753 McKay, J.C. (1973) Letter sent to Harold Wright dated Mar 2, 1973 [Determinations for residues of tetrahydrophthalamic acid-Captan].  (Unpublished study received Mar 9, 1973 under 3E1367; prepared by Stauffer Chemical Co., submitted by American Seed Trade Association, Inc., Kalamazoo, Mich.; CDL:096506-D)

00106602 Stauffer Chemical Company (1975) Summary of Crop Residue Data Supporting Registration of Captan: Imidan 16:12-WP.  (Compilation; unpublished study received Mar 21, 1975 under 476-2172; CDL:028453-D)

00117087 Maddy, K.; Kahn, C.; Riddle, L.; et al. (1977) A Breakdown Study of Captan ... on Strawberry Foliage and Fruit in Ventura County, California:  ACF 59-372.  (California, Dept. of Food and Agriculture, Agricultural Chemicals and Feed; unpublished study; CDL:248429-E)

00117088 Maddy, K.; Edmiston, S.; Kahn, C.; et al. (1977) A Study of the Decay of Captan on the Foliage and Fruit of Strawberries in Santa Cruz County, California: ACF 59-376.  (California, Dept. of Food and Agriculture, Agricultural Chemicals and Feed; unpublished study; CDL:248429-F)

00128355 Chevron Chemical Co. (1982) Residue Chemistry Data: [Captan].  (Compilation; unpublished study received May 19, 1983 under 3F2898; CDL:071624-A; 071625; 071626)

00159596 Captan Task Force (1985) Summary of Residue Data:  Orthocide 50W in Almonds: Test No. T-6268.  Unpublished compilation prepared in cooperation with Morse Labs.  6 p.

00159597 Captan Task Force (1985) Summary of Residue Data:  Orthocide 50W in Red Delicious Apples: Test No. T-6649.  Unpublished compilation prepared in cooperation with Morse Labs.  18 p.

00159599 Captan Task Force (1985) Summary of Residue Data:  Orthocide 50WP in Celery: Test No. T-6269.  Unpublished compilation prepared in cooperation with Morse Labs.  35 p.

00159601 Captan Task Force (1985)  Orthocide 50W Residues in Grapes.  Unpublished compilation prepared in cooperation with Morse Labs.  29 p.

00159605 Captan Task Force (1985) Summary of Residue Data:  Orthocide 50W in Leaf Lettuce: Test Nos. T-6276 and T-6285.  Unpublished compilation prepared in cooperation with Morse Labs.  20 p.

00159606 Captan Task Force (1986) Summary of Residue Data:  Orthocide 50W in Spinach: Test No. T-6280.  Unpublished compilation prepared in cooperation with Morse Labs.  12 p.

00159607 Captan Task Force (1985) Summary of Residue Data:  Orthocide 50W in Strawberries.  Unpublished compilation prepared in cooperation with Morse Labs.  20 p.

00162037 Breault, G. (1986) Addendum to Residue Reduction of Captan and THPI on Crops: Data Call in: R-218.  Unpublished compilation prepared by Chevron Chemical Co.  110 p.

40010501 Graham, D. (1986) Captan--Magnitude of the Residues: Poultry and Eggs (Magnitude of Residues of Captan and its Major Metabolites in Eggs and Chicken Tissues): Project ID. RRC 86-63.  Unpublished study prepared by Stauffer Chemical Co.  183 p.

40189802 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue:  Crop Field Trials: Almond:  Chevron Study No. 056131-B.  Unpublished study prepared in cooperation with Morse Laboratories.  246 p.

40189803 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue:  Crop Field Trials: Apples:  Chevron Study No. 056131-C.  Unpublished study prepared in cooperation with Morse Laboratories.  454 p.

40189804 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue:  Processed Food/Feed Study: Apples: Chevron Study No. 056131-D.  Unpublished study prepared in cooperation with Morse Laboratories.  82 p.

40189805 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Crop Field Trials: Apricot: Chevron Study No. 056131-E.  Unpublished study prepared in cooperation with Morse Laboratories.  163 p.

40189806 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Crop Field Trials: Beet: Chevron Study No. 056131-F.  Unpublished study prepared in cooperation with Morse Laboratories.  97 p.

40189808 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Crop Field Trials: Cherry: Chevron Study No. 056131-H.  210 p.

40189809 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Crop Field Trials: Corn: Chevron Study No. 056131-I.  Unpublished study prepared in cooperation with Morse Laboratories.  187 p.

40189811 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue:  Crop Field Trials: Grape: Chevron Study No. 056131-K.  378 p.

40189812 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Processed Food/Feed Study: Grapes: Chevron Study 045131-L.  Unpublished study prepared in cooperation with Morse Laboratories.  154 p.

40189813 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Crop Field Trials: Nectarine: Chevron Study No. 056131-M.  151 p.

40189814 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Crop Field Trials: Peach: Chevron Study No. 056131-N.  339 p.

40189815 Reed D. Smith Associates, Inc. (1987) Magnitude of Residue: Crop Field Trials: Pear: Chevron Study No. 056131-O.  Unpublished study prepared in cooperation with Morse Laboratories.  316 p.

40189816 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue:  Crop Field Trials: Plum: Chevron Study No. 056131-P.  Unpublished study prepared in cooperation with Morse Laboratories.   217 p.

40189817 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Processed Food/Feed Study: Prunes: Chevron Study No. 056131-Q.  Unpublished study prepared in cooperation with Morse Laboratories.  77 p.

40189820 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Crop Field Trials: Soybean: Chevron Study No. 056131-T.  Unpublished study prepared in cooperation with Morse Laboratories.  174 p.

40189821 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Crop Field Trials: Spinach: Chevron Study No. 056131-U.  Unpublished study prepared in cooperation with Morse Laboratories.   121 p.

40189822 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Crop Field Trials: Strawberries: Chevron Study No. 056131-V.  Unpublished study prepared in cooperation with Morse Laboratories.  262 p.

40189823 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Crop Field Trials: Tomato: Chevron Study No. 056131-W.  Unpublished study prepared in cooperation with Morse Laboratories.  217 p.

40189824 Reed D. Smith Associates, Inc. (1987) Captan: Magnitude of Residue: Processed Food/Feed Study: Tomatoes: Chevron Study No. 056131-X.  Unpublished study prepared in cooperation with Morse Laboratories.  123 p.

40658002 Daun, R. (1988) [Trichloromethyl-[Carbon 14]]Captan:  Nature of the Residue in Livestock-Lactating Goats: Laboratory Project ID: HLA 6183-105.  Unpublished study prepared by Hazleton Laboratories, Inc.  67 p.

40658003 Daun, R. (1988) [Trichloromethyl-[Carbon 14]]Captan:  Nature of the Residue in Livestock-Laying Hens: Laboratory Project ID: HLA 6183-106.  Unpublished study prepared by Hazleton Laboratories America, Inc.  62 p.

40658004 Daun, R. (1988) [Cyclohexene-1,2-[Carbon 14]]Captan:  Nature of the Residue in Livestock-Laying Hens: Laboratory Project ID: HLA 6183-104.  Unpublished study prepared by Hazleton Laboratories America, Inc.  79 p.

40658005 Chen, Y. (1988) Plant Metabolism Study of [Trichloromethyl-[Carbon 14]-Captan:  Laboratory Project ID:  MEF-0009/8808900.  Unpublished study prepared by Chevron Chemical Co.  37 p.

40658006 Chen, Y. (1988) Plant Metabolism Study of [Cyclohexene-1,2-[Carbon 14]]-Captan:  Laboratory Project ID: MEF-0010/8805420.  Unpublished study prepared by Chevron Chemical Co.  38 p.

40745402 Reed D. Smith Associates, Inc. (1988) Captan ... Magnitude of Residue, Crop Field Trials: Almond: Project ID. 87-718.  Unpublished compilation prepared in cooperation with Morse Laboratories.   125 p.

40745403 Reed D. Smith Associates, Inc. (1988) Captan ... Magnitude of Residue, Crop Field Trials: Apple: Project ID. 87-304.  Unpublished compilation prepared in cooperation with Morse Laboratories.  86 p.

40745405 Reed D. Smith Associates, Inc. (1988) Captan ... Magnitude of Residue, Crop Field Trials: Grape: Project ID. 87-167.  Unpublished compilation prepared in cooperation with Morse Laboratories.  88 p.

40745406 Reed D. Smith Associates, Inc. (1988) Captan ... Magnitude of Residue, Crop Field Trials: Peach: Project ID. 87-984.  Unpublished compilation prepared in cooperation with Morse Laboratories.  110 p.

40745407 Reed D. Smith Associates, Inc. (1988) Captan ... Magnitude of Residue, Crop Field Trials: Peach (WA): Project ID. 87-916.  89 p.

40745408 Reed D. Smith Associates, Inc. (1988) Captan ... Magnitude of Residue, Crop Field Trials: Strawberry: Project ID. 87-722.  Unpublished compilation prepared in cooperation with Morse Laboratories.  107 p.

40752301 McKay, J. (1988) Captan and THPI--Storage Stability Study: Various Crops: Interim Report: Laboratory Project ID RRC-88-35.  Unpublished study prepared by Chevron Environmental Center in cooperation with Morse Laboratories, Inc. and Hazleton Laboratories America, Inc.  247 p.

41039101 Biehn, W. (1989) Captan: Magnitude of Residue on Blueberry: IR-4 PR No. 3458.  Unpublished study prepared by Morse Laboratories, Inc.  237 p.

41149101 Curry, K. (1989) Captan Magnitude of the Residue Study in Soybeans Grown from CAPTAN-treated Seed: Project ID WRC 89-31.  Unpublished study prepared by Morse Laboratories, Inc.  125 p.

41149102 Curry, K. (1989) Captan Magnitudes of the Residue Study in Spinach Grown from CAPTAN-treated Seed: Project ID WRC 89-32.  Unpublished study prepared by Morse Laboratories, Inc.  152 p.

41149103 Curry, K. (1989) Captan Magnitude of the Residue Study in Corn Grown from CAPTAN-treated Seed: Project ID WRC 89-33.  Unpublished study prepared by Morse Laboratories, Inc.  144 p.

41149104 Curry, K. (1989) Captan Magnitudes of the Residue Study in Beets Grown from CAPTAN-treated Seed: Project ID WRC 89-34.  Unpublished study prepared by Morse Laboratories, Inc.  141 p.

41306101 Curry, K. (1989) Captan: Magnitude of the Residue Study on Winter Wheat Grown from Captan-Treated Seed:  Lab Project Number:  RR/89/053B.   Unpublished study prepared by  Morse Laboratories, Inc.  188 p.

41306102 Curry, K. (1989) Captan: Magnitude of the Residue Study on Soybean Forage Grown from Captan-Treated Seed:  Lab Project Number:  RR/89/062B.   Unpublished study prepared by Morse Laboratories, Inc.  104 p.

41386501 Davy, G. (1989) ICI Agrochemicals Residue Analytical Method No. 166: The Determination of Residues of Tetrahydrophthalimide, 3-Hydroxy Tetrahydrophthalimide and 5-Hydroxy Tetrahydrophthalimide in Milk and Animal Tissues: A Gas Liquid Chromatographic:  Mass-selective Detector Method Using External Standardization.  Unpublished study prepared by ICI Agrochemicals.  38 p.

41393001 Yancey, M. (1989) Final Report on PR 88-5 Analytical Validation for ICI Agrochemical Residue Analytical Method 152 for Residues of THPI, 3-Hydroxy THPI and 5-Hydroxy THPI in Eggs: Lab Project Number: NO967-0701: ICI Protocol NO. CAPT-CL-AM-01.  Unpublished study prepared by Battelle.  27 p.

41404001 Ewing, A.; Krauter, G.; Ruzo, L. (1990) Confined Rotational Crop Study of [Ring-carbon 14] and [Trichloromethyl-carbon 14]-Captan with Beets Lettuce and Wheat:  Lab Project Number:  PTRL-EAST 241:  PTRL-WEST 137W.  Unpublished study prepared by Pharmacology & Toxicology Research Laboratory-West.  124 p.

41406901 Davy, G.; Atreya, N. (1989) The Determination of Residues of Tetrahydrophthalimide, 3-Hydroxy Tetrahydrophthalimide and 5-Hydroxy Tetrahydrophthalimide in Eggs:  A Gas Liquid Chromatographic Mass-selective Detector Method Using External Standardization.  ...Method No. 152.  Unpublished study prepared by ICI Agrochemicals, Jealotts Hill Research Station.  30 p.

41468401 Curry, K. (1990) Residue Data Review for Soybean and Wheat Seed Treatments with Captan, Record No. 256461; ID No. 10182-293; DEB No. 6142; MRID Nos. 413061-01 and-02 and Residue Data Review for Corn, Soybeans, Beet and Spinach Seed Treatments with Captan, DEB No. 5589, EPA No. 239-124; MRID Nos. 411491-01 through-04.  Unpublished study prepared by Captan Task Force, 30 p.

41557601 McKay, J. (1990) Captan and THPI--Storage Stability Study:  Various Crops.  Storage Stability Validation for Captan (N(trichloromethylthio) cyclohex-4-ene-1,2-dicarboximide and THPI (tetrahydrophtalimide) in Raw and Processed Agricultural Commodities:  Lab Project Number:  RR90-368B.  Unpublished study prepared by Chevron Environmental Ctr. in coop. with Morse Labs, Inc. and Hazleton Labs America, Inc.  354 p.

41746001 Chen, Y. (1988) Plant Metabolism Study of (trichloromethyl-[carbon14]

Cyclohexene-1,2-[carbon 14])-Captan:  Lab Project Number:  MEF-0010/8805420:  MEF-0009/8808900.  Unpublished study prepared by Chevron Chemical Co.  41 p.

42109601 Yeh, S. (1988) Addendum to Carbon-14 Captan Plant Metabolism Studies:  Lab Project Number:  MEF-009:  MEF-010:  RR 91-091B.  Unpublished study prepared by Chevron Chemical Co.  20 p.

42252201 McKay, J. (1990) Captan 50-WP: Magnitude-of-the-Residue Study on Apples Residue Data for Captan and Tetrahydrophthalimide:  Lab Project Number: CAPT-89-MR-02.  Unpublished study prepared by ICI Americas Inc., and Morse Labs., Inc.  145 p.

42252202 McKay, J. (1991) Captan 50-WP: Magnitude-of-the-Residue Study on Apples Treated with a Post Harvest Dip: Lab Project Number: CAPT-90-MR-03.  Unpublished study prepared by ICI Americas Inc., and Morse Labs., Inc.  91 p.

42254202 McKay, J. (1990) Captan 50-WP: Magnitude-of-the-Residue Study on Grapes: Residue Data for Captan and Tetrahydrophthalimide: Lab Project Number: CAPT-89-MR-07: RR 90-379B.  Unpublished study prepared by ICI Americas, Inc. and Morse Laboratories, Inc.  176 p.

42296002 Wiebe, L. (1991) Captan: Magnitude of the Residue of Captan Metabolites in Bovine Meat and Milk: Lab Project Number: CAPT-90-AT-01.  Unpublished study prepared by ICI Americas, Inc.  364 p.

42296003 Riggle, B. (1991) Captan 50-WP: Magnitude-of-thⵥ敒楳畤瑓摵⁹湯倠潲散獳摥䄠灰敬倠潲 畤瑣㩳䰠扡倠潲敪瑣丠浵敢㩲䌠偁ⵔ㤸倭ⵒ㄰唠灮扵 楬桳摥猠畴祤瀠敲慰敲祢䤠䥃䄠敭楲慣ⱳ䤠据ㄠ㘸 瀠മ

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ᜀ42296004 Riggle, B. (1991) Captan 50-WP: Magnitude-of-the-Residue Study on Processed Grape Products: Lab Project Number: CAPT-89-PR-02.  Unpublished study prepared by ICI Americas, Inc.  227 p.

42378401 Yeh, S. (1992) Addendum to [carbon 14]-Captan Confined Rotational Crop Study (Reference: MRID 41404001; EFGWB #90-0738): Lab Project Number: 241: 137W: RR 92-055B.  Unpublished study prepared by PTRL-EAST and PTRL-WEST.  25 p.

42563101 Iwata, Y. (1992) Captan: Magnitude of the Residue Study on Processed Grape Products: Lab Project Number: CAPT-90-PR-02.  Unpublished study prepared by ICI Americas Inc.  140 p.

42563102 Iwata, Y. (1992) Captan: Magnitude of the Residue Study on Processed Apple Products: Lab Project Number: CAPT-90-023B.  Unpublished study prepared by ICI Americas Inc.  336 p.

42568801 Mueller, A. (1992) Interim Report for Nature of the Residue in Livestock-Replacement Study for MRIDs 40658002-40658004 in Response to DEB#s 6525 and 6526.  Unpublished study prepared by ICI Americas, Inc.  40 p.

42712801 Biehn, W. (1992) Captan: Magnitude of Residue on Raspberries-1991 and 1992 Trials: Lab Project Number: 3953.  Unpublished study prepared by IR-4 Satellite Lab, North Dakota State Univ.  234 p.

42756401 Renwick, R.; Skidmore, M. (1993) Captan: Metabolism in Hens Following Dosing at 10 micro-g/g in the Diet: Lab Project Number: 91JH312: RJ1345B.  Unpublished study prepared by ICI Agrochemicals.  156 p.

42803901 Rhodes, M. (1993) An Addendum to MRIDs 40752301, 41557601, and 40189801: A Summary of Storage Stability Information for Captan in Magnitude of the Residue and Processing Studies for Foliar and Post-Harvest Uses as was Requested in the Residue Chemistry Reregistration Standard Update.  Unpublished study prepared by Reed D. Smith Assocs., Morse Labs, Hazleton Labs America, Inc. and Chevron Env. Ctr.  36 p.

43266701 Mathis, S & Skidmore, M. (1994) 14C-Trchloromethyl Captan: Metabolism in Hens Following Dosing at 10 mg/kg in the Diet:Nature of the Residue in Eggs and Tissue, Final Report.  Lab Project Number: 91JH366: RJ1639B.  Unpublished study prepared by ICI Agrochemicals.  158 p.

43266702 Powell, S., Miles, P. & Skidmore, M. (1994) 14C-Trchloromethyl Captan: Metabolism in Goats Following Dosing at 50 mg/kg in the Diet:Nature of the Residue in Milk and Tissue, Final Report.  Lab Project Number: 91JH955: RJ1650B.  Unpublished study prepared by ICI Agrochemicals.  185 p.

43489701 Biehn, W. (1994) Captan: Magnitude of Residue on Strawberries. Laboratory Project No. IR-4 PR No. 5326. Unpublished study prepared by IR-4 Satellite Lab, Rutgers University. 606 p.

43875603 Meyers, T. & Wiebe, L. (1995) Captan : Stabilities of Captan in Milk and Five Captan Metabolites in Animal Tissues and Milk During Storage at -20∘ C ± 10∘  C. Lab Report No. RR95-021B. Study No. CAPT-90-55-01. Unpublished study prepared by Morse Laboratories, Sacramento, CA. 56 p.

44227201 Biehn, W. (1997) Captan: Magnitude of Residue on Raspberries - 1995 Trials. Laboratory Project No. IR-4 PR No. 3953. Unpublished study prepared by IR-4 Satellite Lab, Rutgers University. 553 p.

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