Draft date: 03/ 31/ 05 1 Proposed Interview Domains for NCS Pilot Cohort Assessment at:

Domains Prepregnancy visits Pregnancy visits Birth/ childhood visits Acceptability Questionnaire length Sensitivity of questions Reasons for refusal or participation W, M W W, M Activity Work Recreation/ sports Household ( e. g., childcare) Activity at different points prior to pregnancy Activity during pregnancy Child's activities ( e. g., developmental, handto mouth, pica behavior) W, M W, M W, M Alcohol Frequency/ quantity Changes in consumption after pregnancy Knowledge of effects of alcohol consumption during pregnancy W, M W, M W, M Chemical exposures Occupation ( specific chemicals, smoking policy, use of protective equipment?) Home ( age of home, lead, radon, mold) Other ( e. g., hobbies) W, M W, M W, M Child development Behavioral Social Injuries Sleep patterns/ difficulties   W Demographics Age/ DOB Race/ ethnicity Marital status Nativity Education Income Occupation ( updated as necessary) W, M

Dental health W W Diet  Maternal Foods Fast foods Beverages ( diet, caffeine) Nutritional awareness Special diet ( e. g., low sodium, low fat, organic food) Changes in diet after pregnancy W W W Diet  Child Breastfeeding: knowledge of benefits, when stopped, problems breastfeeding Formulas Vitamins, supplements Solid foods: when started, types Fast food  W Draft date: 03/ 31/ 05 2 Assessment at:

Domains Prepregnancy visits Pregnancy visits Birth/ childhood visits Drugs Prescription OTC Vitamins/ supplements ( e. g., folic acid, herbal) Fertility W W W Family history Parental marital status Family composition Stability as a child Mother/ Father health history W, M

Financial security Economic assistance Food security Economic stressors W W W Household composition Number Relationship to respondent Household responsibilities W

Medical history and health conditions Allergies Asthma Diabetes Hypertension? Hypercholesterol? Specific conditions of interest during pregnancy ( e. g., infections, fever, vaginal bleeding, pre eclampsia) STDs Other conditions W, M W W Medical health conditions   Child Allergies Asthma Etc.   W Medical care Availability Prenatal care Health insurance Special healthcare programs for low income Care at delivery Vaccinations/ regular check ups for child  W W Mental health Feelings about pregnancy Depression Stress Anxiety Major life events Social support  W W Neighborhood conditions Traffic Safety Poverty level Factors affecting mental health W W  Draft date: 03/ 31/ 05 3 Assessment at:

Domains Prepregnancy visits Pregnancy visits Birth/ childhood visits Pets and pests W W W Reproductive health Current contraception Pregnancy status Reproductive history W

Tobacco ETS Self Changes in tobacco use during/ after pregnancy Changes in ETS after pregnancy W W W, M NOTE: Respondent types are noted in each cell for each domain and visit type. M indicates Man ( i. e. father); W indicates Woman ( i. e. mother). Draft date: 03/ 31/ 05 4 Proposed Non Interview Domains for NCS Pilot Cohort Assessment at:

Domains Prepregnancy visits Pregnancy visits Birth/ childhood visits Physical exam Blood pressure W W W Anthropometry W, M W W, C Fetal ultrasound  W W, M Biologic samples Blood W, M W W, C Cord blood   W Cord sample   W Hair W, M Meconium   W Nails W, M W C Placenta   W Placental photo   W Saliva W W C Semen M   Urine W W  Vaginal swab W W W Breast Milk   W Dermal W, M  C Environmental samples Personal Air: Assess sample integrity resulting from participant deployed and collected sample; comparison of techniciancollected and participant collected samples  W W Personal Air: Assess feasibility of using an active sampler for collecting personal air samples for particles and dust; incorporate motion sensing feature to assess participant compliance  W W Surface Dust: Compare participant and technician collected samples for wipes on various painted surfaces; compare to direct xray fluorescence technique for measuring lead in painted surfaces W

Floor Dust: Determine participant ability to collect vacuum and wipe samples from floor surfaces; employ pre deposited plates and carpets and compare with techniciancollection  W W Soil: Assessment of participant proficiency in collection of surface soil samples by video review of actual collection  W

Water: Investigate participant compliance with sample storage protocol  W

NOTE: Respondent types are noted in each cell for each domain and visit type. M indicates Man ( i. e. father); W indicates Woman ( i. e. mother); C indicates Child