TOTAL LITTERS WITH EXTERNAL VARIATIONS	[0/24]

[0/24]

[0/24]

[0/24]

	TOTAL FETUSES WITH EXTERNAL MALFORMATIONS	2/358

1/362

1/369

1/366

TOTAL LITTERS WITH EXTERNAL MALFORMATIONS	[2/24]

[1/24]

[1/24]

[1/24]

	TOTAL FETUSES WITH VISCERAL VARIATIONS	0/181

1/179

0/186

0/184

TOTAL LITTERS WITH VISCERAL VARIATIONS	[0/24]

[1/24]

[0/24]

[0/24]

	TOTAL FETUSES WITH VISCERAL MALFORMATIONS	4/181

3/179

2/186

1/184

TOTAL LITTERS WITH VISCERAL MALFORMATIONS	[4/24]

[3/24]

[2/24]

[1/24]

	TOTAL FETUSES WITH SKELETAL VARIATIONS	27/177

32/183

30/183

35/182

TOTAL LITTERS WITH SKELETAL VARIATIONS	[13/24]

[16/24]

[15/24]

[16/24]

	TOTAL FETUSES WITH SKELETAL MALFORMATIONS	2/177

2/183

0/183

0/182

TOTAL LITTERS WITH SKELETAL MALFORMATIONS	[2/24]

[2/24]

[0/24]

[0/24]

	EXTERNAL EXAMINATIONS

	               - TOTAL FETUSES EXAMINED:	358

362

369

366

               - TOTAL LITTERS EXAMINED:	[24]

[24]

[24]

[24]

	INDIVIDUAL EXTERNAL OBSERVATIONS

	               STUNTED  (<4.0 grams)	3

3

1

3

	[2]

[3]

[1]

[3]

	               FETUS DISCOLORED RED	0

2

0

0

	[0]

[2]

[0]

[0]

H-1

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL EXTERNAL MALFORMATIONS

	               MALROTATED PAW	1

0

1

1

	[1]

[0]

[1]

[1]

	               FILAMENTOUS TAIL	1

0

0

0

	[1]

[0]

[0]

[0]

	               MICROSTOMIA	0

1

0

0

	[0]

[1]

[0]

[0]

	               CLEFT PALATE	0

1

0

0

	[0]

[1]

[0]

[0]

	VISCERAL EXAMINATIONS

	               - TOTAL FETUSES EXAMINED:	181

179

186

184

               - TOTAL LITTERS EXAMINED:	[24]

[24]

[24]

[24]

	INDIVIDUAL VISCERAL VARIATIONS

	               DILATED CEREBRAL VENTRICLE	0

1

0

0

	[0]

[1]

[0]

[0]

H-2

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL VISCERAL MALFORMATIONS

	               ANOPHTHALMIA	0

1

0

0

	[0]

[1]

[0]

[0]

	               HYDROURETER	1

0

0

0

	[1]

[0]

[0]

[0]

	               HYDRONEPHROSIS	3

1

1

1

	[3]

[1]

[1]

[1]

	               MALPOSITIONED NASAL SEPTUM	0

1

0

0

	[0]

[1]

[0]

[0]

	               RETINA FOLD	0

1

0

0

	[0]

[1]

[0]

[0]

	               HYDROCEPHALY	0

0

1

0

	[0]

[0]

[1]

[0]

	SKELETAL EXAMINATIONS

	               - TOTAL FETUSES EXAMINED:	177

183

183

182

               - TOTAL LITTERS EXAMINED:	[24]

[24]

[24]

[24]

	INDIVIDUAL OSSIFICATION VARIATIONS

	               STERNEBRAE:

	                         ASYMMETRIC	0

1

1

1

	[0]

[1]

[1]

[1]

H-3

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL OSSIFICATION VARIATIONS (cont'd)

	                         BIFID	0

1

1

0

	[0]

[1]

[1]

[0]

	                         HYPOPLASTIC	0

1

1

0

	[0]

[1]

[1]

[0]

	                         DUMBBELL / 8 SHAPED	0

0

1

0

	[0]

[0]

[1]

[0]

	                          SUPERNUMERARY OSSIFICATION SITE	0

1

0

0

	[0]

[1]

[0]

[0]

	                         UNOSSIFIED	3

1

0

3

	[2]

[1]

[0]

[2]

	               RIBS:

	                         SHORT LAST THORACIC	0

0

0

1

	[0]

[0]

[0]

[1]

	                         RUDIMENTARY LUMBAR	3

5

6

11

	[3]

[5]

[4]

[5]

	                         WELL-FORMED CERVICAL	0

1

0

0

	[0]

[1]

[0]

[0]

	                         WELL-FORMED LUMBAR	0

1

0

1

	[0]

[1]

[0]

[1]

H-4

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL OSSIFICATION VARIATIONS (cont'd)

	            VERTEBRAE:

	                  EXTRA CERVICAL VERTEBRAE	0

1

0

0

	[0]

[1]

[0]

[0]

	                  THORACIC CENTRA BIFID	12

14

9

9

	[7]

[6]

[8]

[7]

	                  THORACIC CENTRA DUMBBELL / 8 SHAPED	0

0

3

0

	[0]

[0]

[3]

[0]

	                  THORACIC CENTRA HYPOPLASTIC	0

1

1

0

	[0]

[1]

[1]

[0]

	                  EXTRA LUMBAR VERTEBRAE	1

0

0

0

	[1]

[0]

[0]

[0]

	                 LUMBAR CENTRA BIFID	0

1

0

0

	[0]

[1]

[0]

[0]

	                  SACRAL CENTRA UNOSSIFIED	1

0

0

0

	[1]

[0]

[0]

[0]

H-5

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL CARTILAGINOUS VARIATIONS

             STERNEBRAE ANLAGE:

	                      MULTIPLE BONES HYPOPLASTIC	5

2

3

2

	[3]

[1]

[1]

[2]

             RIB ANLAGE:

                      MULTIPLE BONES HYPOPLASTIC	5

4

7

6

	[3]

[3]

[4]

[4]

	                      SUPERNUMERARY ANLAGE	2

2

1

6

	[1]

[1]

[1]

[2]

             VERTEBRAE ANLAGE:

	                CERVICAL CENTRA HYPOPLASTIC	1

0

1

0

	[1]

[0

[1]

[0]

	                THORACIC CENTRA HYPOPLASTIC	2

8

8

8

	[2]

[4]

[4]

[5]

	                THORACIC CENTRA DUMBBELL / 8 SHAPED	0

    9

5

2

	[0]

[3]

[5]

[2]

	               THORACIC CENTRA BIFID	0

2

1

2

	[0]

[2]

[1]

[2]

H-6

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL OSSIFICATION MALFORMATIONS

	           VERTEBRAE:

	                   CERVICAL MULTIPLE BONES MALFORMED	0

1

0

0

	[0]

[1]

[0]

[0]

	                  THORACIC CENTRA MISSHAPEN	1

0

0

0

	[1]

[0]

[0]

[0]

	                  LUMBAR ONE LESS PRESACRAL	0

1

0

0

	[0]

[1]

[0]

[0]

	                   SACRAL MULTIPLE BONES ABSENT	1

0

0

0

	[1]

[0]

[0]

[0]

	                   CAUDAL MULTIPLE BONES ABSENT	1

0

0

0

	[1]

[0]

[0]

[0]

	INDIVIDUAL CARTILAGINOUS MALFORMATIONS

	           VERTEBRAE:

	                THORACIC CENTRA MISSHAPEN	1

0

0

0

	[1]

[0]

[0]

[0]

H-7

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK329F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1        A          M              +             +              +

 2        A          F              +                                            +

 3        A          M              +             +              +

 4        A          F              +                                            +

 5        A          M              +             +              +

 6        A          F              +                                            +

 7        A          F              +             +              +

 8        A          F              +                                            +

 9        A          M              +             +              +

10        A          F              +                                            +

11        A          M              +             +              +

12C       A          M              +                                            +

 E

13        A          F              +             +              +

14        A          M              +                                            +

15        A          F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-8

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK327F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  3     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +              +

 2         A         F              +                                          (b,c)

 3         A         M              +              +              +

 4         A         F              +                                            +

 5         A         F              +              +              +

 6         A         M              +                                            +

 7C        A         M              +              +              +

 E

 8         A         F              +                                            +

 9         A         F              +              +              +

10         A         M              +                                          (b,c)

11         A         M              +              +             (A)

12         A         M              +                                           (d)

13         A         F              +              +              +

14         A         M              +                                            +

15         A         F              +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(A) - ABDOMEN/THORAX: Hydroureter; Left

(b) - SKELETAL/STERNEBRAE (Anlage):  Multiple hypoplastic

(c) - SKELETAL/RIBS (Anlage):  Multiple hypoplastic

(d) - SKELETAL/VERTEBRAE (T2-3 Anlage):  Hypoplastic centra

H-9

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK332F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  1

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                             +

 2         A         M              +              +              +

 3         A         F              +                                           (A,B)

 4         A         F              +              +              +

 5C        A         F              +                                             +

 6         A         F              +              +              +

 E

 7         A         F              +                                             +

 8         A         M              +              +              +

 9         A         M              +                                             +

 E

 E

10         A         M              +              +              +

11         A         M              +                                             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(A) - SKELETAL/VERTEBRAE (T5):  Misshapen centra

(B) - SKELETAL/VERTEBRAE (T5 Anlage):  Misshapen centra

H-10

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK337F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +             +              +

 2         A         M              +                                            +

 3         A         F              +             +              +

 E

 4         A         F              +                                            +

 5         A         F              +             +              +

 6         A         F              +                                            +

 7         A         F              +             +              +

 8C        A         F              +                                            +

 9         A         F             (A)            +              +

10         A         M              +                                            +

11         A         F              +             +              +

12         A         F              +                                            +

 E

13         A         M              +             +             (B)

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(A) - EXTERNAL: Malrotated hindpaw; Left

(B) - ABDOMEN/THORAX:  Hydronephrosis; Right

H-11

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK331F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +              +

 2         A         F              +                                            +

 3         A         F              +             +              +

 4         A         F              +                                            +

 5         A         M              +             +              +

 6         A         F              +                                           (a)

 7         A         M              +             +              +

 8C        A         F              +                                            +

 9         A         F              +             +              +

10         A         F              +                                            +

11         A         F              +             +              +

12         A         F              +                                            +

13         A         F              +             +              +

14         A         M              +                                           (b)

15         A         M              +             +              +

16         A         M              +                                            +

17         A         M              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (V):  Unossified

(b) - SKELETAL/STERNEBRAE (I):  Unossified

H-12

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK351F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +             +              +

 2         A         F              +                                            +

 3         A         F              +             +              +

 4         A         F              +                                            +

 5         A         F              +             +              +

 6         A         M              +                                            +

 7         A         F              +             +              +

 8C        A         M              +                                            +

 9         A         M              +             +              +

 E

10         A         M              +                                            +

11         A         F              +             +              +

12         A         M              +                                            +

13         A         F              +             +              +

14         A         F              +                                            +

15         A         F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-13

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK360F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         F              +              +              +

 3         A         M              +                                           (a)

 4         A         F              +              +              +

 5C        A         F              +                                            +

 6         A         F              +              +              +

 7         A         M              +                                            +

 8         A         M              +              +              +

 9         A         F              +                                            +

10         A         F              +              +              +

11         A         F              +                                            +

12         A         F              +              +              +

13         A         M              +                                            +

14         A         F              +              +              +

15         A         F              +                                            +

16         A         M              +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T13):  Bifid centra

H-14

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK334F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         F              +              +             (A)

 3         A         F              +                                            +

 4         A         M              +              +              +

 5         A         F              +                                            +

 6         A         M              +              +              +

 7         A         F              +                                            +

 8C        A         M              +              +              +

 9         A         M              +                                            +

10         A         M              +              +              +

11         A         F              +                                            +

12         A         F              +              +              +

13         A         F              +                                            +

14         A         M              +              +              +

15         A         F              +                                            +

16         A         M              +              +              +

17         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

- ABDOMEN THORAX: Hydronephrosis; Bilateral

H-15

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK370F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         F              +              +             +

 3         A         M              +                                            +

 4         A         M              +              +             +

 5         A         F              +                                            +

 E

 6C        A         F              +              +             +

 7         A         F              +                                            +

 8         A         M              +              +             +

 9         A         F              +                                            +

10         A         F              +              +             +

11         A         M              +                                            +

12         A         M              +              +             +

13         A         M              +                                           (a)

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE: Fetus numbers 11 and 13 found with identification tags detached, numbers

      arbitrarily assigned for skeletal exams

(a) - SKELETAL/VERTEBRAE (T11):  Bifid centra

H-16

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK343F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  5     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +              +

 2         A         F              +                                          (a,b)

 3         A         M              +              +              +

 4         A         M              +                                            +

 E

 5         A         F              +              +              +

 6         A         F              +                                           (c)

 7         A         F              +              +              +

 8C        A         F              +                                           (c)

 9         A         F              +              +              +

10         A         M              +                                           (b)

11         A         M              +              +              +

12         A         M              +                                           (c)

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (V):  Unossified

(b) - SKELETAL/VERTEBRAE (T11):  Bifid centra

(c) - SKELETAL/VERTEBRAE (T12):  Bifid centra

H-17

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK373F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +             +

 2         A         F              +                                            +

 3         A         M              +              +             +

 4         A         F              +                                           (a)

 5         A         F              +              +             +

 6         A         F              +                                            +

 7         A         M              +              +             +

 8         A         M              +                                           (a)

 9C        A         F              +              +             +

10         A         F              +                                            +

11         A         M              +              +             +

12         A         M              +                                            +

13         A         M              +              +             +

14         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T11):  Bifid centra

H-18

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK346F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  3     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         F              +              +            +

 3         A         F              +                                            +

 4         A         F              +              +            +

 5         A         M              +                                           (c)

 6         A         M              +              +            +

 7         A         F              +                                            +

 8         A         M              +              +            +

 9         A         M              +                                            +

10C        A         M              +              +            +

11         A         M              +                                            +

12         A         F              +              +            +

13         A         M              +                                           (b)

14         A         F              +              +            +

15         A         F              +                                           (a)

16         A         M              +              +            +

17         A         M              +                                            +

18         A         M              +              +            +

19         A         M              +                                            +

20         A         M              +              +            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:    Fetus numbers 7 and 13 found with identification tags detached, numbers

      arbitrarily assigned for skeletal exams

(a) - SKELETAL/RIBS (T11 Anlage):  Site of extra rudimentaty anlage; Left

(b) - SKELETAL/RIBS (T11 Anlage):  Site of extra rudimentary anlage; Bilateral

(c) - SKELETAL/VERTEBRAE (T10):  Bifid centra

H-19

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK379F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +              +

 2         A         M              +                                             +

 3         A         M              +             +              +

 4         A         F              +                                             +

 5         A         F              +             +              +

 6         A         F              +                                             +

 7         A         M              +             +              +

 8         A         F              +                                             +

 9         A         F              +             +              +

10         A         M              +                                             +

11         A         F              +             +              +

12C        A         M              +                                             +

13         A         M              +             +              +

 E

14         A         F              +                                            (a)

15         A         M              +             +              +

16         A         M              +                                             +

17         A         M              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

- SKELETAL/VERTEBRAE (T11,12):  Bifid centra

H-20

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK342F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         M              +             +             +

 3         A         M              +                                            +

 4         A         F              +             +             +

 5C        A         M              +                                            +

 6         A         M              +             +             +

 7         A         M              +                                           (a)

 8         A         F              +             +             +

 9         A         F              +                                            +

10         A         M              +             +             +

11         A         F              +                                            +

12         A         F              +             +             +

13         A         M              +                                            +

14         A         M              +             +             +

15         A         M              +                                            +

16         A         M              +             +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:  Fetus numbers 1, 3, 7, 9, and 13 found with identification tags detached, numbers

      arbitrarily assigned for skeletal exams

(a) - SKELETAL/RIBS (L1):  Rudimentary; Right

H-21

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK378F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         M              +             +            +

 3         A         M              +                                            +

 E

 4         A         M              +             +            +

 5         A         F              +                                            +

 6         A         M              +             +            +

 7         A         F              +                                            +

 8         A         M              +             +            +

 9C        A         F              +                                            +

10         A         M              +             +            +

11         A         M              +                                            +

12         A         F              +             +            +

13         A         F              +                                            +

14         A         M              +             +            +

15         A         F              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-22

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK402F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                             +

 2         A         F              +             +              +

 E

 3         A         F              +                                             +

 4         A         F              +             +              +

 5C        A         F              +                                             +

 6         A         M              +             +             (A)

 7         A         F              +                                             +

 8         A         M              +             +              +

 9         A         F              +                                             +

10         A         F              +             +              +

11         A         F              +                                             +

12         A         F              +             +              +

13         A         F              +                                             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:  Fetus numbers 1, 9, 11, and 13 found with identification tags detached, numbers

      arbitrarily assigned for skeletal exams

- ABDOMEN/THORAX:  Hydronephrosis; Bilateral

H-23

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK419F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +             +

 2         A         F              +                                            +

 3         A         F              +             +             +

 4         A         M              +                                            +

 5         A         F              +             +             +

 6C        A         M              +                                            +

 7         A         F              +             +             +

 8         A         F              +                                            +

 9         A         F              +             +             +

10         A         F              +                                            +

11         A         M              +             +             +

12         A         F              +                                            +

13         A         F              +             +             +

14         A         M              +                                            +

15         A         F              +             +             +

16         A         F              +                                            +

17         A         F              +             +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-24

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK388F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                             +

 2*        A         F              +             +              +

 3         A         M              +                                             +

 4         A         M              +             +              +

 5         A         F              +                                             +

 6         A         F              +             +              +

 7         A         M              +                                             +

 8         A         M              +             +              +

 9C        A         M              +                                             +

10         A         M              +             +              +

11         A         M              +                                             +

12         A         M              +             +              +

13         A         F              +                                             +

14*        A         F              +             +              +

15         A         M              +                                             +

16         A         M              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

 *  - Stunted

H-25

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK439F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  1

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1*        A         F              +              +              +

 2         A         M              +                                             +

 3         A         M              +              +              +

 4         A         M              +                                             +

 5         A         M              +              +              +

 6         A         M             (A)                                         (d,E,F)

 7         A         F              +              +              +

 8C        A         M              +                                           (b,c)

 E

 9         A         M              +              +              +

10         A         M              +                                             +

11         A         F              +              +              +

12         A         M              +                                             +

13         A         M              +              +              +

14         A         M              +                                             +

15         A         F              +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

 *  - Stunted

(A) - EXTERNAL:  Filamentous tail

(b) - SKELETAL/RIBS (L1):  Rudimentary; Bilateral

(c) - SKELETAL/VERTEBRAE (L):  Presacral

(d) - SKELETAL/VERTEBRAE (S4):  Unossified centra

(E) - SKELETAL/VERTEBRAE (S CENTRA, ARCH):  Multiple bones absent

(F) - SKELETAL/VERTEBRAE (CA CENTRA, ARCH):  Multiple bones absent

H-26

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK431F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +              +

 2         A         M              +                                            +

 3         A         M              +             +              +

 4         A         F              +                                            +

 5         A         M              +             +              +

 6         A         F              +                                            +

 7C        A         M              +             +              +

 8         A         F              +                                            +

 E

 9         A         F              +             +              +

10         A         M              +                                            +

11         A         F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-27

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK433F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +             +             +

 2         A         F              +                                           (c,d)

 3         A         F              +             +             +

 4         A         M              +                                             +

 5         A         F              +             +             +

 6         A         F              +                                             +

 7         A         M              +             +             +

 8         A         M              +                                             +

 9C        A         F              +             +             +

10         A         F              +                                           (a,b)

11         A         M              +             +             +

12         A         M              +                                             +

13         A         M              +             +             +

14         A         M              +                                             +

15         A         M              +             +             +

16         A         F              +                                             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:  Fetus numbers 4, 10, and 16 found with identification tags detached, numbers

      arbitrarily assigned for skeletal exams

(a) - SKELETAL/STERNEBRAE (Anlage):  Multiple hypoplastic

(b) - SKELETAL/RIBS (Anlage):  Multiple hypoplastic

(c) - SKELETAL/RIBS (L1):  Rudimentary; Bilateral

(d) - SKELETAL/VERTEBRAE (CE4,7 Anlage):  Hypoplastic centra

H-28

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK435F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +              +              +

 2         A         M              +                                            +

 3         A         M              +              +              +

 4C        A         M              +                                           (a)

 5         A         M              +              +              +

 6         A         M              +                                            +

 7         A         M              +              +              +

 8         A         F              +                                            +

 9         A         F              +              +              +

10         A         F              +                                            +

11         A         F              +              +              +

12         A         F              +                                            +

13         A         F              +              +              +

14         A         M              +                                            +

15         A         F              +              +              +

16         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T11,12):  Bifid centra

H-29

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK446F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  3     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         M              +             +              +

 3         A         M              +                                            +

 4         A         F              +             +              +

 5         A         M              +                                            +

 6         A         M              +             +              +

 7C        A         F              +                                          (b,c)

 8         A         F              +             +              +

 9         A         M              +                                           (a)

10         A         F              +             +              +

11         A         F              +                                          (a,b)

12         A         M              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (Anlage):  Multiple hypoplastic

(b) - SKELETAL/RIBS (Anlage):  Multiple hypoplastic

(c) - SKELETAL/VERTEBRAE (T6-9 Anlage):  Hypoplastic centra

H-30

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGK447F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +              +

 2         A         F              +                                             +

 3         A         F              +              +              +

 4         A         F              +                                             +

 5         A         F              +              +              +

 6         A         M              +                                             +

 7         A         F              +              +              +

 8C        A         F              +                                             +

 9         A         F              +              +              +

10         A         F              +                                             +

11         A         M              +              +              +

12         A         M              +                                             +

13         A         F              +              +              +

14         A         F              +                                             +

15         A         M              +              +              +

16         A         F              +                                             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE: Fetus numbers 8, 12, and 14 found with identification tags detached, numbers

      arbitrarily assigned for skeletal exams

H-31

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:   2000 MG/M3

ANIMAL NUMBER:  IGK328F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  3     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            (a)

 2         A         F              +             +               +

 3         A         F              +                                           (b,c)

 4         A         M              +             +               +

 5         A         F              +                                             +

 6         A         M              +             +               +

 7         A         M              +                                             +

 8         A         M              +             +               +

 9         A         F              +                                             +

10         A         F              +             +               +

11         A         M              +                                          (d,e,f)

12         A         M              +             +               +

13C        A         F              +                                             +

14         A         F              +             +               +

 E

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T6-9 Anlage):  Hypoplastic centra

(b) - SKELETAL/VERTEBRAE (T9):  Bifid centra

(c) - SKELETAL/VERTEBRAE (T5-6 Anlage):  Hypoplastic centra

(d) - SKELETAL/VERTEBRAE (T11):  Bifid centra

(e) - SKELETAL/VERTEBRAE (T11 Anlage):  Bifid centra

(f) - SKELETAL/VERTEBRAE (T5-7 Anlage):  Hypoplastic centra

H-32

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK338F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  4     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                             +

 2         A         M              +             +             +

 3         A         F              +                                           (a,h)

 4         A         F              +             +             +

 5         A         M              +                                             +

 6         A         M              +             +             +

 7C        A         F              +                                           (b,c)

 8         A         F              +             +             +

 9         A         M              +                                           (d,e)

10         A         F              +             +             +

11         A         F              +                                           (f,g)

12         A         F              +             +             +

13         A         M              +                                             +

14         A         F              +             +             +

15         A         M              +                                             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE: Fetus numbers 1, 5, and 7 found with identification tags detached, numbers

      arbitrarily assigned for skeletal exams

(a) - SKELETAL/VERTEBRAE (T11,12):  Bifid centra

(b) - SKELETAL/VERTEBRAE (T11):  Bifid centra

(c) - SKELETAL/VERTEBRAE (T11 Anlage):  Dumbbell centra

(d) - SKELETAL/VERTEBRAE (T9-13):  Bifid centra

(e) - SKELETAL/VERTEBRAE (T9-13 Anlage):  Dumbbell centra

(f) - SKELETAL/VERTEBRAE (T11-13):  Bifid centra

(g) - SKELETAL/VERTEBRAE (T11-13 Anlage):  Dumbbell centra

(h) - SKELETAL/VERTEBRAE (L1):  Bifid centra

H-33

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK330F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         F              +             +             +

 3         A         M              +                                            +

 4         A         F              +             +             +

 5         A         M              +                                            +

 6         A         F              +             +             +

 7C        A         F              +                                           (a)

 8         A         M              +             +             +

 9         A         F              +                                            +

10         A         F              +             +             +

11         A         F              +                                            +

12         A         F              +             +             +

13         A         M              +                                            +

14         A         F              +             +             +

15         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

- SKELETAL/VERTEBRAE (T3-7 Anlage):  Hypoplastic centra

H-34

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK341F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  4     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +              +

 2         A         F              +                                           (d)

 3         A         F              +             +              +

 4         A         F              +                                            +

 5         A         M              +             +              +

 6         A         M              +                                           (e)

 7         A         M              +             +              +

 8C        A         M              +                                          (a,b)

 9         A         M              +             +              +

10         A         M              +                                         (a,b,c)

11         A         F              +             +              +

12         A         F              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (Anlage):  Multiple hypoplastic

(b) - SKELETAL/RIBS (Anlage):  Multiple hypoplastic

(c) - SKELETAL/RIBS (L1):  Rudimentary; Bilateral

(d) - SKELETAL/VERTEBRAE (T4-5 Anlage):  Hypoplastic centra

(e) - SKELETAL/VERTEBRAE (T3-6 Anlage):  Hypoplastic centra

H-35

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK362F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 E

 1         A         M              +                                             +

 2         A         F              +             +               +

 3         A         F              +                                             +

 4         A         F              +             +               +

 5         A         F              +                                             +

 E

 6C        A         M              +             +               +

 7         A         M              +                                             +

 8         A         M              +             +               +

 9         A         M              +                                             +

10         A         M              +             +               +

11         A         F              +                                             +

12         A         F              +             +               +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-36

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK364F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  5     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         M              +              +              +

 3         A         F              +                                            +

 4         A         F              +              +              +

 5         A         M              +                                        (c,d,e,g)

 6         A         M              +              +              +

 EC

 7         A         F              +                                            +

 8         A         M              +              +              +

 9         A         M              +                                          (d,e)

10         A         M              +              +              +

11         A         F              +                                        (c,d,e,g)

12         A         F              +              +              +

13         A         F              +                                         (a,b,f)

14         A         F              +              +              +

15         A         F              +                                          (c,g)

16         A         F              +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1):  Rudimentary; Bilateral

(b) - SKELETAL/VERTEBRAE (T13):  Bifid centra

(c) - SKELETAL/VERTEBRAE (T11):  Bifid centra

(d) - SKELETAL/VERTEBRAE (T12):  Bifid centra

(e) - SKELETAL/VERTEBRAE (T12 Anlage):  Dumbbell centra

(f) - SKELETAL/VERTEBRAE (T13 Anlage):  Dumbbell centra

(g) - SKELETAL/VERTEBRAE (T11 Anlage):  Dumbbell centra

H-37

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK358F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 E

 2         A         F              +              +              +

 3         A         M              +                                            +

 4         A         M              +              +              +

 5C        A         F              +                                           (b)

 6         A         F              +              +              +

 7         A         M              +                                           (a)

 8         A         M              +              +              +

 9         A         F              +                                            +

10         A         F              +              +              +

11         A         F              +                                            +

12         A         F              +              +              +

13         A         M              +                                            +

14         A         F              +              +              +

15         A         F              +                                            +

16         A         F              +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1):  Rudimentary; Left

(b) - SKELETAL/VERTEBRAE (T11-12, T11-12 Anlage):  Bifid centra

H-38

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK416F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         F              +              +              +

 3         A         M              +                                            +

 4         A         M              +              +              +

 5         A         M              +                                            +

 6         A         F              +              +              +

 7         A         F              +                                            +

 8C        A         F              +              +              +

 9         A         M              +                                            +

10         A         F              +              +              +

11         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-39

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK359F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +              +

 2         A         F              +                                            +

 3         A         F              +             +              +

 4         A         F              +                                           (a)

 5         A         M              +             +              +

 6         A         F              +                                            +

 7         A         F              +             +              +

 8C        A         M              +                                            +

 9         A         M              +             +              +

10         A         F              +                                            +

11         A         M              +             +              +

12         A         F              +                                           (b)

13         A         F              +             +              +

14         A         F              +                                            +

15         A         F              +             +              +

16         A         M              +                                            +

17         A         M              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T4-10 Anlage):  Hypoplastic centra

(b) - SKELETAL/VERTEBRAE (T5-9 Anlage):  Hypoplastic centra

H-40

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK347F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +              +

 2         A         M              +                                             +

 3         A         F              +             +              +

 4C*       A         F              +                                            (a)

 5         A         M              +             +              +

 6         A         F              +                                             +

 7         A         F              +             +              +

 8         A         F              +                                             +

 9         A         M              +             +              +

 E

 E

10         A         M              +                                             +

11         A         F              +             +              +

 E

12         A         M              +                                             +

13         A         F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:  * - Stunted

- SKELETAL/STERNEBRAE (VI):  Hypoplastic

H-41

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK335F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +             +              +

 2         A         F              +                                            +

 E

 3         A         M              +             +              +

 4         A         M              +                                            +

 5         A         F              +             +              +

 E

 6C        A         M              +                                            +

 7         A         F              +             +              +

 8         A         F              +                                            +

 9         A         F              +             +              +

10         A         F              +                                            +

 E

11         A         M              +             +              +

12         A         M              +                                            +

13         A         M              +             +              +

14         A         F              +                                            +

15         A         M              +             +              +

16         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-42

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK418F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2*        A         F           (A,B,**)        (C,D)           +

 3         A         M              +                                            +

 4         A         M              +              +             +

 5         A         M              +                                            +

 6         A         F              +              +             +

 7         A         F              +                                            +

 8         A         F              +              +             +

 9         A         F              +                                            +

10C        A         M              +              +             +

11         A         F              +                                            +

12         A         M              +              +             +

13         A         M              +                                            +

14         A         M              +              +             +

15         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:  * - Stunted

(A)  - EXTERNAL:  Microstomia

(B)  - EXTERNAL:  Cleft palate (confirmed internally)

(**) - EXTERNAL:  Fetus discolored red

(C)  - HEAD:  Anophthalmia

(D)  - HEAD:  Malpositioned nasal septum

H-43

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK413F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  1     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +             +              +

 2         A         F              +                                            +

 3         A         M              +             +              +

 4         A         M              +                                            +

 5         A         M              +             +              +

 6         A         M              +                                            +

 7         A         M              +             +              +

 8         A         M              +                                            +

 9C        A         M              +             +              +

10         A         M              +                                            +

11         A         M              +            (a)             +

12         A         M              +                                            +

13         A         M              +             +              +

14         A         F              +                                            +

15         A         M              +             +              +

16         A         M              +                                            +

17         A         M              +             +              +

18         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE: Fetus numbers 6, 12, and 14 found with identification tags detached, numbers

      arbitrarily assigned for skeletal exams

- HEAD:  Dilated cerebral ventricle

H-44

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK425F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +              +              +

 2         A         M              +                                            +

 3         A         F              +              +              +

 4         A         M              +                                            +

 5         A         M              +              +              +

 6         A         F              +                                           (a)

 7         A         M              +              +              +

 8C        A         F              +                                            +

 9         A         F              +              +              +

10         A         M              +                                           (b)

11         A         M              +              +              +

12         A         F              +                                            +

13         A         F              +              +              +

14         A         M              +                                            +

15         A         F              +              +              +

16         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (T11 Anlage):  Site of extra rudimentary anlage; Bilateral

(b) - SKELETAL/RIBS (T11 Anlage):  Site of extra rudimentary anlage; Left

H-45

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK422F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         M              +              +              +

 3         A         F              +                                            +

 4         A         F              +              +              +

 5         A         M              +                                            +

 6C        A         F              +              +              +

 7         A         F              +                                            +

 8         A         F              +              +              +

 9         A         M              +                                            +

10         A         F              +              +              +

11         A         M              +                                            +

12         A         M              +              +              +

13         A         F              +                                            +

14         A         F              +              +              +

15         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-46

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK384F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                          (a,b)

 2         A         M              +             +              +

 3         A         F              +                                            +

 4         A         F              +             +              +

 5         A         F              +                                            +

 6         A         F              +             +              +

 7         A         M              +                                            +

 E

 8         A         F              +             +              +

 9C        A         M              +                                            +

10         A         F              +             +              +

11         A         M              +                                            +

12         A         F              +             +              +

13         A         F              +                                            +

14         A         F              +             +              +

15         A         F              +                                            +

16         A         F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (Anlage):  Multiple hypoplastic

(b) - SKELETAL/RIBS (L1):  Rudimentary; Bilateral

H-47

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK386F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         M              +             +               +

 3         A         M              +                                            +

 4         A         F              +             +               +

 5         A         F              +                                            +

 6         A         F              +             +               +

 7         A         M              +                                            +

 8C        A         M              +             +               +

 9         A         F              +                                            +

10         A         F              +             +               +

11         A         M              +                                            +

12         A         F              +             +               +

13         A         M              +                                            +

14         A         F              +             +               +

15         A         F              +                                            +

16         A         F              +             +               +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE: Fetus numbers 1 and 7 found with identification tags detached, numbers

      arbitrarily assigned for skeletal exams

H-48

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK442F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  1

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         M              +              +              +

 3         A         M              +                                            +

 4         A         F              +              +              +

 5*        A         F            (**)                                    (a,b,c,d,e,f,G,h)

 E

 6         A         M              +              +              +

 7         A         M              +                                            +

 EC

 8         A         M              +              +              +

 9         A         M              +                                            +

10         A         M              +              +              +

11         A         F              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:  * - Stunted

(**) - EXTERNAL:  Fetus discolored red

(a) - SKELETAL/STERNEBRAE (I-III):  Assymetric form

(b) - SKELETAL/STERNEBRAE (IV):  Bifid centra

(c) - SKELETAL/STERNEBRAE (V-VI):  Unossified

(d) - SKELETAL/RIBS (CE8):  Well-formed; Right

(e) - SKELETAL/RIBS (L1):  Well-formed: Left

(f) - SKELETAL/VERTEBRAE (CE): Presacral

(G) - SKELETAL/VERTEBRAE (CE):  Multiple bones malformed

(h) - SKELETAL/VERTEBRAE (T3-6):  Hypoplastic centra

H-49

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK466F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  1

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         F              +             +             +

 3         A         F              +                                            +

 4         A         M              +             +             +

 5         A         F              +                                          (c,D)

 6         A         F              +             +             +

 7         A         F              +                                            +

 8         A         M              +             +            (A)

 9         A         M              +                                            +

10         A         F              +             +             +

11         A         M              +                                            +

12C        A         M              +             +             +

13         A         F              +                                            +

14         A         M              +             +             +

15         A         M              +                                           (b)

16         A         M              +             +             +

17         A         F              +                                            +

18         A         F              +             +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(A) - ABDOMEN/THORAX:  Hydronephrosis; Bilateral

(b) - SKELETAL/STERNEBRAE (Between V and VI): Site of extra ossification site

(c) - SKELETAL/RIBS (Anlage):  Multiple hypoplastic

(D) - SKELETAL/VERTEBRAE (L):  One less presacral

H-50

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK430F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +

 2         A         F              +              +              +               +

 3         A         M              +

 4         A         M              +              +              +               +

 L

 5         A         F              +                                             +

 6         A         M              +              +              +

 7         A         M              +                                             +

 8         A         M              +              +              +

 9C        A         F              +                                             +

10         A         M              +             (A)             +

11         A         M              +                                             +

12         A         F              +              +              +

13         A         F              +                                            (b)

14         A         F              +              +              +

15         A         M              +                                             +

16         A         M              +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(A) - HEAD: Retina fold; Right

(b) - SKELETAL/RIBS (L1):  Rudimentary; Bilateral

H-51

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK445F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +             +

 2         A         M              +                                             +

 3         A         F              +             +             +

 4         A         M              +                                            (a)

 5         A         M              +             +             +

 6         A         M              +                                             +

 7         A         M              +             +             +

 8         A         F              +                                             +

 9         A         M              +             +             +

10         A         F              +                                             +

11C        A         M              +             +             +

12         A         M              +                                             +

13         A         M              +             +             +

14         A         F              +                                             +

 E

15         A         M              +             +             +

16         A         F              +                                             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

-  SKELETAL/VERTEBRAE (T12):  Bifid centra

H-52

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK452F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         F              +              +              +

 3         A         M              +                                            +

 4         A         F              +              +              +

 5         A         F              +                                            +

 6         A         M              +              +              +

 7         A         F              +                                            +

 8         A         F              +              +              +

 9C        A         F              +                                            +

10         A         M              +              +              +

11         A         F              +                                            +

12         A         F              +              +              +

13         A         M              +                                            +

14         A         F              +              +              +

15         A         F              +                                            +

 E

16         A         M              +              +              +

17         A         F              +                                           (a)

18         A         F              +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

- SKELETAL/VERTEBRAE (T12):  Bifid centra

H-53

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK471F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 E

 1         A         F              +              +             +

 2         A         M              +                                            +

 3         A         M              +              +             +

 4         A         F              +                                            +

 5         A         F              +              +             +

 6C        A         M              +                                            +

 7         A         M              +              +             +

 8         A         F              +                                            +

 9         A         F              +              +             +

10         A         M              +                                            +

11         A         F              +              +             +

12         A         M              +                                            +

13         A         M              +              +             +

14         A         F              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-54

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGK458F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                           (a)

 2         A         F              +              +             +

 3         A         F              +                                            +

 4         A         M              +              +             +

 5         A         M              +                                            +

 6         A         M              +              +             +

 7         A         F              +                                            +

 8         A         F              +              +             +

 9         A         M              +                                            +

10         A         M              +              +             +

11         A         M              +                                            +

12C        A         F              +              +             +

13         A         F              +                                            +

14         A         M              +              +             +

15         A         F              +                                            +

16         A         M              +              +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE: Fetus numbers 5, 7, 11, and 15 found with identification tags detached, numbers

      arbitrarily assigned for skeletal exams

(a) - SKELETAL/VERTEBRAE (T10 Anlage):  Dumbbell centra

H-55

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGK369F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +              +

 2         A         M              +                                            +

 3         A         F              +              +              +

 4         A         M              +                                            +

 5         A         M              +              +              +

 6         A         F              +                                            +

 7         A         M              +              +              +

 8         A         M              +                                            +

 9         A         F              +              +              +

10         A         F              +                                            +

11         A         F              +              +              +

12C        A         M              +                                            +

13         A         F              +              +              +

14         A         F              +                                            +

15         A         F              +              +              +

16         A         M              +                                            +

17         A         F              +              +              +

18         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-56

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGK339F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +            +

 2         A         M              +                                            +

 3         A         M              +              +            +

 4         A         M              +                                            +

 5         A         F              +              +            +

 6         A         M              +                                            +

 7         A         M              +              +            +

 8C        A         M              +                                            +

 9         A         M              +              +            +

10         A         F              +                                            +

11         A         F              +              +            +

12         A         F              +                                            +

13         A         M              +              +            +

14         A         F              +                                            +

15         A         F              +              +            +

16         A         F              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-57

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGK361F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +             +            +

 E

 2         A         F              +                                             +

 3         A         M              +             +            +

 4C        A         F              +                                             +

 5         A         M              +             +            +

 6         A         M              +                                             +

 7         A         M              +             +            +

 8         A         M              +                                             +

 9         A         M              +             +            +

10         A         M              +                                             +

11         A         F              +             +            +

12         A         F              +                                            (a)

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

- SKELETAL/VERTEBRAE (T12):  Bifid centra

H-58

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGK356F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                             +

 2         A         F              +              +            +

 3         A         M              +                                             +

 4         A         F              +              +            +

 5         A         M              +                                             +

 6C        A         F              +              +            +

 7         A         M              +                                             +

 8         A         M              +              +            +

 9         A         F              +                                             +

10         A         F              +              +            +

11         A         M              +                                             +

12         A         M              +              +            +

13         A         F              +                                             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE: Fetus numbers 3, 9, and 13 found with identification tags detached, numbers

      arbitrarily assigned for skeletal exams

H-59

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGK355F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +             +             +

 2         A         F              +                                             +

 3         A         M              +             +             +

 4*        A         M              +                                            (a)

 5         A         F              +             +             +

 6         A         F              +                                             +

 7         A         F              +             +             +

 8         A         M              +                                             +

 9         A         F              +             +             +

10C        A         M              +                                             +

11         A         F              +             +             +

12         A         M              +                                           (b,c)

13         A         M              +             +             +

14         A         M              +                                             +

15         A         M              +             +             +

16         A         F              +                                             +

17         A         M              +             +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

 * - Stunted

(a) - SKELETAL/RIBS (Anlage):  Multiple hypoplastic

(b) - SKELETAL/VERTEBRAE (T9):  Dumbbell centra

(c) - SKELETAL/VERTEBRAE (T9 Anlage):  Dumbbell centra

H-60

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGK357F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  5     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +              +              +

 2         A         F              +                                            +

 3         A         M              +              +              +

 4         A         M              +                                           (d)

 5C        A         F              +              +              +

 6         A         M              +                                         (a,b,e)

 7         A         F              +              +              +

 8         A         M              +                                         (b,c,f)

 9         A         M              +              +              +

10         A         M              +                                          (a,b)

11         A         M              +              +              +

12         A         M              +                                         (a,b,g)

13         A         F              +              +              +

14         A         F              +                                           +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (Anlage):  Multiple hypoplastic

(b) - SKELETAL/RIBS (Anlage):  Multiple hypoplastic

(c) - SKELETAL/VERTEBRAE (CE7 Anlage):  Hypoplastic centra

(d) - SKELETAL/VERTEBRAE (T3-5 Anlage):  Hypoplastic centra

(e) - SKELETAL/VERTEBRAE (T3-4 Anlage):  Hypoplastic centra

(f) - SKELETAL/VERTEBRAE (T1-3 Anlage):  Hypoplastic centra

(g) - SKELETAL/VERTEBRAE (T1-5 Anlage):  Hypoplastic centra

H-61

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGK348F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         M              +             +             +

 3         A         F              +                                            +

 4         A         F              +             +             +

 5         A         M              +                                            +

 6         A         M              +             +             +

 7         A         M              +                                            +

 8         A         M              +             +             +

 9         A         M              +                                            +

10C        A         F              +             +             +

11         A         F              +                                            +

12         A         M              +             +             +

13         A         M              +                                            +

14         A         F              +             +             +

15         A         F              +                                            +

16         A         M              +             +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-62

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGK368F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         M              +              +              +

 3         A         F              +                                            +

 E

 4         A         F              +              +              +

 5         A         F              +                                           (b)

 6         A         F              +              +              +

 7         A         F              +                                           (c)

 8C        A         M             (A)             +              +

 9         A         M              +                                            +

10         A         M              +              +              +

11         A         M              +                                            +

12         A         M              +              +              +

13         A         F              +                                            +

14         A         M              +              +              +

15         A         F              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE: Fetus numbers 3, 5, 7, 9, and 15 found with identification tags detached, numbers

      arbitrarily assigned for skeletal exams

(A) - EXTERNAL:  Malrotated forepaw; Left

(b) - SKELETAL/VERTEBRAE (T10,13):  Bifid centra

(c) - SKELETAL/VERTEBRAE (T11,12):  Bifid centra

H-63

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGK393F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +              +             +

 2         A         M              +                                            +

 3         A         M              +              +             +

 4         A         M              +                                            +

 5         A         F              +              +             +

 6C        A         M              +                                            +

 7         A         M              +              +             +

 8         A         F              +                                            +

 9         A         F              +              +             +

10         A         F              +                                            +

11         A         M              +              +             +

12         A         F              +                                            +

13         A         M              +              +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-64

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGK336F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         M              +             +            +

 3         A         F              +                                            +

 4         A         F              +             +            +

 5         A         F              +                                          (b,c)

 6         A         F              +             +            +

 7C        A         F              +                                            +

 8         A         F              +             +            +

 9         A         M              +                                            +

10         A         M              +             +            +

11         A         M              +                                           (a)

12         A         F              +             +            +

13         A         F              +                                            +

14         A         F              +             +            +

15         A         M              +                                            +

16         A         M              +             +            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (Anlage):  Multiple hypoplastic

(b) - SKELETAL/VERTEBRAE (T12):  Bifid centra

(c) - SKELETAL/VERTEBRAE (T12 Anlage):  Dumbbell centra

H-65

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGK409F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  3     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +              +

 2         A         F              +                                             +

 3         A         F              +              +              +

 4         A         M              +                                             +

 5         A         M              +              +              +

 6         A         M              +                                             +

 7         A         F              +              +              +

 8         A         M              +                                            (a)

 9         A         F              +              +              +

10         A         M              +                                            (b)

11         A         F              +              +              +

12C        A         F              +                                             +

13         A         F              +              +              +

14         A         F              +                                            (c)

15         A         F              +              +              +

16         A         F              +                                             +

 E

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T4-7 Anlage):  Hypoplastic centra

(b) - SKELETAL/VERTEBRAE (T6-7 Anlage):  Hypoplastic centra

(c) - SKELETAL/VERTEBRAE (T12 Anlage):  Dumbbell centra

H-66

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(SEE KEY B FOR ABBREVIATIONS)

TARGET DOSE:  10000 MG/M3