i e d   S i t e ) :     A d e n o m a   o r   C a r c i n o m a O v e r a l l   r a t e 1 0 / 5 0   ( 2 0 % ) 7 / 5 0   ( 1 4 % ) 1 2 / 4 8   ( 2 5 % ) 8 / 4 9   ( 1 6 % ) A d j u s t e d   r a t e 2 1 . 2 % 1 8 . 1 % 2 7 . 0 % 2 1 . 1 % T e r m i n a l   r a t e 9 / 4 2   ( 2 1 % ) 3 / 1 3   ( 2 3 % ) 9 / 3 2   ( 2 8 % ) 4 / 2 1   ( 1 9 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 6 4 5 1 4 6 8 7 6 1 9 P o l y - 3   t e s t P = 0 . 5 3 2 N P = 0 . 4 6 2 N P = 0 . 3 4 4 P = 0 . 5 9 8 N A l l   O r g a n s :     H e m a n g i o s a r c o m a O v e r a l l   r a t e 3 / 5 0   ( 6 % ) 4 / 5 0   ( 8 % ) 1 / 5 0   ( 2 % ) 1 / 5 0   ( 2 % ) A d j u s t e d   r a t e 6 . 4 % 1 0 . 7 % 2 . 2 % 2 . 6 % T e r m i n a l   r a t e 2 / 4 2   ( 5 % ) 1 / 1 3   ( 8 % ) 1 / 3 3   ( 3 % ) 0 / 2 1   ( 0 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 6 4 6 7 4 7 3 5   ( T ) 7 2 7 P o l y - 3   t e s t P = 0 . 3 2 0 N P = 0 . 3 7 8 P = 0 . 3 1 5 N P = 0 . 3 8 6 N A l l   O r g a n s :     H e m a n g i o m a   o r   H e m a n g i o s a r c o m a O v e r a l l   r a t e 4 / 5 0   ( 8 % ) 4 / 5 0   ( 8 % ) 2 / 5 0   ( 4 % ) 1 / 5 0   ( 2 % ) A d j u s t e d   r a t e 8 . 5 % 1 0 . 7 % 4 . 3 % 2 . 6 % T e r m i n a l   r a t e 3 / 4 2   ( 7 % ) 1 / 1 3   ( 8 % ) 1 / 3 3   ( 3 % ) 0 / 2 1   ( 0 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 6 4 6 7 4 6 7 2 7 2 7 P o l y - 3   t e s t P = 0 . 2 0 2 N P = 0 . 5 1 3 P = 0 . 3 4 8 N P = 0 . 2 5 1 N A l l   O r g a n s :     H i s t i o c y t i c   S a r c o m a O v e r a l l   r a t e 1 / 5 0   ( 2 % ) 3 / 5 0   ( 6 % ) 1 / 5 0   ( 2 % ) 3 / 5 0   ( 6 % ) A d j u s t e d   r a t e 2 . 1 % 7 . 9 % 2 . 2 % 7 . 7 % T e r m i n a l   r a t e 1 / 4 2   ( 2 % ) 0 / 1 3   ( 0 % ) 0 / 3 3   ( 0 % ) 0 / 2 1   ( 0 % ) F i r s t   i n c i d e n c e   ( d a y s ) 7 3 5   ( T ) 5 3 3 6 9 1 5 1 2 P o l y - 3   t e s t P = 0 . 1 5 4 P = 0 . 2 3 5 P = 0 . 7 5 7 P = 0 . 2 4 5   A l l   O r g a n s :     M a l i g n a n t   L y m p h o m a O v e r a l l   r a t e 8 / 5 0   ( 1 6 % ) 4 / 5 0   ( 8 % ) 1 0 / 5 0   ( 2 0 % ) 1 3 / 5 0   ( 2 6 % ) A d j u s t e d   r a t e 1 7 . 0 % 1 0 . 6 % 2 0 . 9 % 3 3 . 2 % T e r m i n a l   r a t e 7 / 4 2   ( 1 7 % ) 1 / 1 3   ( 8 % ) 5 / 3 3   ( 1 5 % ) 7 / 2 1   ( 3 3 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 9 9 6 1 7 5 4 7 6 0 0 P o l y - 3   t e s t P = 0 . 0 5 3 P = 0 . 2 9 9 N P = 0 . 4 1 3 P = 0 . 0 6 6   2 6 0 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   D 3 S t a t i s t i c a l   A n a l y s i s   o f   P r i m a r y   N e o p l a s m s   i n   F e m a l e   M i c e   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) A l l   O r g a n s :     B e n i g n   N e o p l a s m s O v e r a l l   r a t e 2 5 / 5 0   ( 5 0 % ) 2 4 / 5 0   ( 4 8 % ) 3 6 / 5 0   ( 7 2 % ) 2 6 / 5 0   ( 5 2 % ) A d j u s t e d   r a t e 5 2 . 9 % 5 9 . 6 % 7 4 . 9 % 6 1 . 7 % T e r m i n a l   r a t e 2 3 / 4 2   ( 5 5 % ) 1 2 / 1 3   ( 9 2 % ) 2 5 / 3 3   ( 7 6 % ) 1 3 / 2 1   ( 6 2 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 6 4 5 1 4 6 1 7 4 9 6 P o l y - 3   t e s t P = 0 . 3 3 2 P = 0 . 3 3 7 P = 0 . 0 1 8 P = 0 . 2 6 3   A l l   O r g a n s :     M a l i g n a n t   N e o p l a s m s O v e r a l l   r a t e 2 0 / 5 0   ( 4 0 % ) 2 5 / 5 0   ( 5 0 % ) 2 5 / 5 0   ( 5 0 % ) 2 7 / 5 0   ( 5 4 % ) A d j u s t e d   r a t e 4 1 . 7 % 5 8 . 8 % 5 1 . 2 % 6 2 . 6 % T e r m i n a l   r a t e 1 5 / 4 2   ( 3 6 % ) 6 / 1 3   ( 4 6 % ) 1 4 / 3 3   ( 4 2 % ) 9 / 2 1   ( 4 3 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 2 6 4 8 9 5 4 7 5 1 2 P o l y - 3   t e s t P = 0 . 0 3 3 P = 0 . 0 7 5 P = 0 . 2 3 4 P = 0 . 0 3 5 A l l   O r g a n s :     B e n i g n   o r   M a l i g n a n t   N e o p l a s m s O v e r a l l   r a t e 3 5 / 5 0   ( 7 0 % ) 3 7 / 5 0   ( 7 4 % ) 4 5 / 5 0   ( 9 0 % ) 4 0 / 5 0   ( 8 0 % ) A d j u s t e d   r a t e 7 3 . 0 % 8 2 . 7 % 9 0 . 0 % 8 9 . 0 % T e r m i n a l   r a t e 3 0 / 4 2   ( 7 1 % ) 1 3 / 1 3   ( 1 0 0 % ) 2 8 / 3 3   ( 8 5 % ) 1 8 / 2 1   ( 8 6 % ) F i r s t   i n c i d e n c e   ( d a y s ) 6 2 6 4 8 9 5 4 7 4 9 6 P o l y - 3   t e s t P = 0 . 0 4 5 P = 0 . 1 8 0 P = 0 . 0 2 5 P = 0 . 0 3 8 ( T ) T e r m i n a l   s a c r i f i c e a N u m b e r   o f   n e o p l a s m - b e a r i n g   a n i m a l s / n u m b e r   o f   a n i m a l s   e x a m i n e d .     D e n o m i n a t o r   i s   n u m b e r   o f   a n i m a l s   e x a m i n e d   m i c r o s c o p i c a l l y   f o r   l i v e r ,   l u n g ,   a n d   p i t u i t a r y g l a n d ;   f o r   o t h e r   t i s s u e s ,   d e n o m i n a t o r   i s   n u m b e r   o f   a n i m a l s   n e c r o p s i e d . b P o l y - 3   e s t i m a t e d   n e o p l a s m   i n c i d e n c e   a f t e r   a d j u s t m e n t   f o r   i n t e r c u r r e n t   m o r t a l i t y c O b s e r v e d   i n c i d e n c e   a t   t e r m i n a l   k i l l d N o t   a p p l i c a b l e ;   n o   n e o p l a s m s   i n   a n i m a l   g r o u p e B e n e a t h   t h e   c h a m b e r   c o n t r o l   i n c i d e n c e   a r e   t h e   P   v a l u e s   a s s o c i a t e d   w i t h   t h e   t r e n d   t e s t   ( t h e   0 . 0 3   m g / m 3   w a s   e x c l u d e d   f r o m   t h e   t r e n d   t e s t ) .     B e n e a t h   t h e   e x p o s e d g r o u p   i n c i d e n c e   a r e   t h e   P   v a l u e s   c o r r e s p o n d i n g   t o   p a i r w i s e   c o m p a r i s o n s   b e t w e e n   t h e   c h a m b e r   c o n t r o l s   a n d   t h a t   e x p o s e d   g r o u p .     T h e   P o l y - 3   t e s t   a c c o u n t s   f o r d i f f e r e n t i a l   m o r t a l i t y   i n   a n i m a l s   t h a t   d o   n o t   r e a c h   t e r m i n a l   s a c r i f i c e .     A   n e g a t i v e   t r e n d   o r   a   l o w e r   i n c i d e n c e   i n   a n   e x p o s u r e   g r o u p   i s   i n d i c a t e d   b y   N . I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 6 1 T A B L E   D 4 a H i s t o r i c a l   I n c i d e n c e   o f   A l v e o l a r / b r o n c h i o l a r   N e o p l a s m s   i n   C o n t r o l   F e m a l e   B 6 C 3 F 1   M i c e I n c i d e n c e   i n   C o n t r o l s S t u d y A d e n o m a C a r c i n o m a A d e n o m a   o r   C a r c i n o m a H i s t o r i c a l   I n c i d e n c e   i n   C o n t r o l s   G i v e n   N T P - 2 0 0 0   F e e d a p , p N - D i c h l o r o d i p h e n y l   s u l f o n e   ( f e e d ) 0 / 5 0 0 / 5 0 0 / 5 0 I n d i u m   p h o s p h i d e   ( i n h a l a t i o n ) 3 / 5 0 1 / 5 0 4 / 5 0 M e t h a c r y l o n i t r i l e   ( g a v a g e ) 6 / 5 0 1 / 5 0 6 / 5 0 p - N i t r o t o l u e n e   ( f e e d ) 5 / 5 0 1 / 5 0 6 / 5 0 S o d i u m   n i t r i t e   ( d r i n k i n g   w a t e r ) 1 / 5 0 0 / 5 0 1 / 5 0 O v e r a l l   H i s t o r i c a l   I n c i d e n c e   i n   C o n t r o l s   G i v e n   N T P - 2 0 0 0   F e e d T o t a l   ( % ) 1 5 / 2 5 0   ( 6 . 0 % ) 3 / 2 5 0   ( 1 . 2 % ) 1 7 / 2 5 0   ( 6 . 8 % ) M e a n   ±   s t a n d a r d   d e v i a t i o n 6 . 0 %   ±   5 . 1 % 1 . 2 %   ±   1 . 1 % 6 . 8 %   ±   5 . 6 % R a n g e 0 % - 1 2 % 0 % - 2 % 0 % - 1 2 % H i s t o r i c a l   I n c i d e n c e   i n   C h a m b e r   C o n t r o l s   G i v e n   N I H - 0 7   F e e d   a t   B a t t e l l e   P a c i f i c   N o r t h w e s t   L a b o r a t o r i e s b A c e t o n i t r i l e 7 / 4 9 1 / 4 9 8 / 4 9 1 , 3 - B u t a d i e n e 4 / 5 0 0 / 5 0 4 / 5 0 2 - B u t o x y e t h a n o l 7 / 5 0 0 / 5 0 7 / 5 0 C h l o r o p r e n e 2 / 5 0 2 / 5 0 4 / 5 0 C o b a l t   s u l f a t e   h e p t a h y d r a t e 3 / 5 0 1 / 5 0 4 / 5 0 F u r f u r y l   a l c o h o l 2 / 5 0 4 / 5 0 6 / 5 0 G a l l i u m   a r s e n i d e 6 / 5 0 1 / 5 0 7 / 5 0 G l u t a r a l d e h y d e 2 / 5 0 1 / 5 0 3 / 5 0 H e x a c h l o r o c y c l o p e n t a d i e n e 4 / 4 8 3 / 4 8 7 / 4 8 I s o b u t e n e 2 / 4 9 4 / 4 9 6 / 4 9 I s o b u t y r a l d e h y d e 0 / 5 0 3 / 5 0 3 / 5 0 M o l y b d e n u m   t r i o x i d e 1 / 5 0 2 / 5 0 3 / 5 0 N i t r o m e t h a n e 3 / 5 0 0 / 5 0 3 / 5 0 O z o n e 4 / 5 0 2 / 5 0 6 / 5 0 T e t r a h y d r o f u r a n 1 / 5 0 1 / 5 0 2 / 5 0 O v e r a l l   H i s t o r i c a l   I n c i d e n c e   i n   C h a m b e r   C o n t r o l s   G i v e n   N I H - 0 7   F e e d T o t a l   ( % ) 6 7 / 1 , 0 7 5   ( 6 . 2 % ) 4 3 / 1 , 0 7 5   ( 4 . 0 % ) 1 0 9 / 1 , 0 7 5   ( 1 0 . 1 % ) M e a n   ±   s t a n d a r d   d e v i a t i o n 6 . 3 %   ±   3 . 7 % 3 . 9 %   ±   3 . 2 % 1 0 . 1 %   ±   3 . 6 % R a n g e 0 % - 1 4 % 0 % - 1 2 % 4 % - 1 6 % a D a t a   a s   o f   1 4   M a r c h   2 0 0 0 b D a t a   a s   o f   2 3   D e c e m b e r   1 9 9 9 2 6 2 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   D 4 b H i s t o r i c a l   I n c i d e n c e   o f   L i v e r   N e o p l a s m s   i n   C o n t r o l   F e m a l e   B 6 C 3 F 1   M i c e I n c i d e n c e   i n   C o n t r o l s H e p a t o c e l l u l a r   A d e n o m a , S t u d y H e p a t o c e l l u l a r H e p a t o c u l l u l a r H e p a t o c e l l u l a r   C a r c i n o m a , A d e n o m a C a r c i n o m a H e p a t o b l a s t o m a o r   H e p a t o b l a s t o m a H i s t o r i c a l   I n c i d e n c e   i n   C o n t r o l s   G i v e n   N T P - 2 0 0 0   F e e d a p , p N - D i c h l o r o d i p h e n y l   s u l f o n e   ( f e e d ) 4 / 5 0 3 / 5 0 0 / 5 0 6 / 5 0 I n d i u m   p h o s p h i d e   ( i n h a l a t i o n ) 1 2 / 5 0 6 / 5 0 0 / 5 0 1 8 / 5 0 M e t h a c r y l o n i t r i l e   ( g a v a g e ) 9 / 5 0 2 / 5 0 0 / 5 0 1 0 / 5 0 p - N i t r o t o l u e n e   ( f e e d ) 6 / 4 9 3 / 4 9 0 / 4 9 8 / 4 9 S o d i u m   n i t r i t e   ( d r i n k i n g   w a t e r ) 9 / 5 0 2 / 5 0 0 / 5 0 1 0 / 5 0 O v e r a l l   H i s t o r i c a l   I n c i d e n c e   i n   C o n t r o l s   G i v e n   N T P - 2 0 0 0   F e e d T o t a l   ( % ) 4 0 / 2 4 9   ( 1 6 . 1 % ) 1 6 / 2 4 9   ( 6 . 4 % ) 0 / 2 4 9 5 2 / 2 4 9   ( 2 0 . 9 % ) M e a n   ±   s t a n d a r d   d e v i a t i o n 1 6 . 1 %   ±   6 . 1 % 6 . 4 %   ±   3 . 3 % 2 0 . 9 %   ±   9 . 1 % R a n g e 8 % - 2 4 % 4 % - 1 2 % 1 2 % - 3 6 % H i s t o r i c a l   I n c i d e n c e   i n   C h a m b e r   C o n t r o l s   G i v e n   N I H - 0 7   F e e d   a t   B a t t e l l e   P a c i f i c   N o r t h w e s t   L a b o r a t o r i e s b A c e t o n i t r i l e 4 / 4 9 7 / 4 9 0 / 4 9 9 / 4 9 1 , 3 - B u t a d i e n e 1 1 / 4 9 4 / 4 9 0 / 4 9 1 5 / 4 9 2 - B u t o x y e t h a n o l 1 6 / 5 0 1 0 / 5 0 0 / 5 0 2 2 / 5 0 C h l o r o p r e n e 1 7 / 5 0 4 / 5 0 0 / 5 0 2 0 / 5 0 C o b a l t   s u l f a t e   h e p t a h y d r a t e 8 / 5 0 1 2 / 5 0 0 / 5 0 1 8 / 5 0 F u r f u r y l   a l c o h o l 7 / 5 0 9 / 5 0 0 / 5 0 1 4 / 5 0 G a l l i u m   a r s e n i d e 1 1 / 5 0 1 2 / 5 0 0 / 5 0 2 1 / 5 0 G l u t a r a l d e h y d e 1 1 / 5 0 4 / 5 0 0 / 5 0 1 4 / 5 0 H e x a c h l o r o c y c l o p e n t a d i e n e 5 / 4 9 4 / 4 9 0 / 4 9 9 / 4 9 I s o b u t e n e 2 0 / 4 7 5 / 4 7 0 / 4 7 2 3 / 4 7 I s o b u t y r a l d e h y d e 9 / 4 9 6 / 4 9 0 / 4 9 1 2 / 4 9 M o l y b d e n u m   t r i o x i d e 9 / 5 0 1 9 / 5 0 0 / 5 0 2 3 / 5 0 N i t r o m e t h a n e 1 4 / 5 0 1 0 / 5 0 0 / 5 0 1 9 / 5 0 O z o n e 2 0 / 5 0 1 5 / 5 0 0 / 5 0 2 7 / 5 0 T e t r a h y d r o f u r a n 1 2 / 5 0 6 / 5 0 0 / 5 0 1 7 / 5 0 O v e r a l l   H i s t o r i c a l   I n c i d e n c e   i n   C h a m b e r   C o n t r o l s   G i v e n   N I H - 0 7   F e e d T o t a l   ( % ) 2 2 4 / 1 , 0 7 2   ( 2 0 . 9 % ) 1 6 8 / 1 , 0 7 2   ( 1 5 . 7 % ) 0 / 1 , 0 7 2 3 4 8 / 1 , 0 7 2   ( 3 2 . 5 % ) M e a n   ±   s t a n d a r d   d e v i a t i o n 2 1 . 0 %   ±   9 . 8 % 1 5 . 7 %   ±   8 . 1 % 3 2 . 6 %   ±   1 0 . 5 % R a n g e 8 % - 4 3 % 8 % - 3 8 % 1 8 % - 5 4 % a D a t a   a s   o f   1 4   M a r c h   2 0 0 0 b D a t a   a s   o f   2 3   D e c e m b e r   1 9 9 9 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 6 3 T A B L E   D 5 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N o n n e o p l a s t i c   L e s i o n s   i n   F e m a l e   M i c e   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e a C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) D i s p o s i t i o n   S u m m a r y A n i m a l s   i n i t i a l l y   i n   s t u d y 6 0 6 0 6 0 6 0 3 - M o n t h   i n t e r i m   e v a l u a t i o n 1 0 1 0 1 0 1 0 E a r l y   d e a t h s A c c i d e n t a l   d e a t h s 1 1 M o r i b u n d 4 3 1 1 5 1 8 N a t u r a l   d e a t h s 3 6 2 1 0 S u r v i v o r s T e r m i n a l   s a c r i f i c e 4 2 1 3 3 3 2 1 A n i m a l s   e x a m i n e d   m i c r o s c o p i c a l l y 6 0 6 0 6 0 6 0 3 - M o n t h   I n t e r i m   E v a l u a t i o n A l i m e n t a r y   S y s t e m L i v e r ( 1 0 ) ( 1 0 ) ( 1 0 ) ( 1 0 ) H e m a t o p o i e t i c   c e l l   p r o l i f e r a t i o n                       1 ( 1 0 % )       2 ( 2 0 % )       3 ( 3 0 % )   N e c r o s i s                       1 ( 1 0 % )                         1 ( 1 0 % )   O v a l   c e l l ,   h y p e r p l a s i a                                         1 ( 1 0 % )       2 ( 2 0 % )   C a r d i o v a s c u l a r   S y s t e m H e a r t ( 1 0 )                 ( 1 0 ) C a r d i o m y o p a t h y     5 ( 5 0 % )                                           7 ( 7 0 % )   H e m a t o p o i e t i c   S y s t e m L y m p h   n o d e ,   b r o n c h i a l   ( 9 )   ( 8 ) ( 1 0 ) ( 1 0 ) F o r e i g n   b o d y                       4 ( 5 0 % )       9 ( 9 0 % )     1 0 ( 1 0 0 % ) H y p e r p l a s i a     1 ( 1 1 % )       5 ( 6 3 % )     1 0 ( 1 0 0 % )   1 0 ( 1 0 0 % ) L y m p h   n o d e ,   m a n d i b u l a r   ( 7 )                   ( 8 ) H y p e r p l a s i a     1 ( 1 4 % )                                                         L y m p h   n o d e ,   m e d i a s t i n a l   ( 4 )   ( 5 )   ( 6 )   ( 6 ) H y p e r p l a s i a                                         4 ( 6 7 % )       3 ( 5 0 % )   S p l e e n ( 1 0 ) ( 1 0 ) ( 1 0 ) ( 1 0 ) H e m a t o p o i e t i c   c e l l   p r o l i f e r a t i o n     4 ( 4 0 % )       9 ( 9 0 % )     1 0 ( 1 0 0 % )   1 0 ( 1 0 0 % ) R e s p i r a t o r y   S y s t e m L a r y n x ( 1 0 )                 ( 1 0 ) I n f l a m m a t i o n ,   s u p p u r a t i v e     1 ( 1 0 % )                                                         S q u a m o u s   e p i t h e l i u m ,   h y p e r p l a s i a     2 ( 2 0 % )                                           3 ( 3 0 % )   L u n g ( 1 0 ) ( 1 0 ) ( 1 0 ) ( 1 0 ) F o r e i g n   b o d y                     1 0 ( 1 0 0 % )   1 0 ( 1 0 0 % )   1 0 ( 1 0 0 % ) I n f l a m m a t i o n ,   c h r o n i c   a c t i v e                       9 ( 9 0 % )       9 ( 9 0 % )       9 ( 9 0 % )   A l v e o l u s ,   p r o t e i n o s i s                     1 0 ( 1 0 0 % )   1 0 ( 1 0 0 % )   1 0 ( 1 0 0 % ) S p e c i a l   S e n s e s   S y s t e m L a c r i m a l   g l a n d   ( 1 )                         I n f l a m m a t i o n ,   s u p p u r a t i v e     1 ( 1 0 0 % )                                                       a N u m b e r   o f   a n i m a l s   e x a m i n e d   m i c r o s c o p i c a l l y   a t   t h e   s i t e   a n d   t h e   n u m b e r   o f   a n i m a l s   w i t h   l e s i o n 2 6 4 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   D 5 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N o n n e o p l a s t i c   L e s i o n s   i n   F e m a l e   M i c e   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) 3 - M o n t h   I n t e r i m   E v a l u a t i o n   ( c o n t i n u e d ) U r i n a r y   S y s t e m K i d n e y ( 1 0 )                 ( 1 0 ) N e p h r o p a t h y     1 ( 1 0 % )                                           4 ( 4 0 % )   S y s t e m s   E x a m i n e d   w i t h   N o   L e s i o n s   O b s e r v e d E n d o c r i n e   S y s t e m G e n e r a l   B o d y   S y s t e m G e n i t a l   S y s t e m I n t e g u m e n t a r y   S y s t e m M u s c u l o s k e l e t a l   S y s t e m N e r v o u s   S y s t e m 2 - Y e a r   S t u d y A l i m e n t a r y   S y s t e m G a l l b l a d d e r ( 4 6 ) ( 4 5 ) ( 4 8 ) ( 4 3 ) D e g e n e r a t i o n ,   h y a l i n e                       1 ( 2 % )                                         I n f l a m m a t i o n ,   s u p p u r a t i v e     2 ( 4 % )         2 ( 4 % )         3 ( 6 % )                       I n t e s t i n e   l a r g e ,   r e c t u m ( 4 7 ) ( 4 9 ) ( 5 0 ) ( 4 9 ) I n f l a m m a t i o n ,   s u p p u r a t i v e                                         1 ( 2 % )                       I n t e s t i n e   s m a l l ,   j e j u n u m ( 4 6 ) ( 4 9 ) ( 4 9 ) ( 4 4 ) P e y e r ’ s   p a t c h ,   h y p e r p l a s i a     1 ( 2 % )                                                           I n t e s t i n e   s m a l l ,   i l e u m ( 4 6 ) ( 4 8 ) ( 5 0 ) ( 4 8 ) E p i t h e l i u m ,   h y p e r p l a s i a     1 ( 2 % )         1 ( 2 % )         1 ( 2 % )                       P e y e r ’ s   p a t c h ,   h y p e r p l a s i a     2 ( 4 % )                                             1 ( 2 % )     L i v e r ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) A n g i e c t a s i s                                         1 ( 2 % )         2 ( 4 % )     B a s o p h i l i c   f o c u s     2 ( 4 % )         2 ( 4 % )                           2 ( 4 % )     C l e a r   c e l l   f o c u s     2 ( 4 % )                                             2 ( 4 % )     E o s i n o p h i l i c   f o c u s     6 ( 1 2 % )       5 ( 1 0 % )       4 ( 8 % )       1 0 ( 2 0 % )   E o s i n o p h i l i c   f o c u s ,   m u l t i p l e                       4 ( 8 % )                           2 ( 4 % )     H e m a t o p o i e t i c   c e l l   p r o l i f e r a t i o n     3 ( 6 % )         3 ( 6 % )         4 ( 8 % )         3 ( 6 % )     H y p e r p l a s i a ,   l y m p h o i d     1 ( 2 % )                                                           I n f l a m m a t i o n                       1 ( 2 % )         1 ( 2 % )                       K a r y o m e g a l y     1 ( 2 % )                                                           N e c r o s i s     4 ( 8 % )         3 ( 6 % )         9 ( 1 8 % )       3 ( 6 % )     T e n s i o n   l i p i d o s i s     2 ( 4 % )         1 ( 2 % )         2 ( 4 % )         1 ( 2 % )     V a c u o l i z a t i o n   c y t o p l a s m i c     1 ( 2 % )                           1 ( 2 % )                       B i l e   d u c t ,   c y s t     1 ( 2 % )                                                           B i l e   d u c t ,   d e g e n e r a t i o n ,   h y a l i n e                                                           1 ( 2 % )     M e s e n t e r y ( 1 3 )   ( 8 )   ( 8 )   ( 4 ) A n g i e c t a s i s     1 ( 8 % )                                                           A r t e r y ,   i n f l a m m a t i o n                       4 ( 5 0 % )       2 ( 2 5 % )       1 ( 2 5 % )   F a t ,   n e c r o s i s   1 0 ( 7 7 % )       3 ( 3 8 % )       6 ( 7 5 % )       3 ( 7 5 % )   P a n c r e a s ( 5 0 ) ( 4 9 ) ( 5 0 ) ( 5 0 ) A t r o p h y     1 ( 2 % )                           1 ( 2 % )         2 ( 4 % )     S a l i v a r y   g l a n d s ( 4 9 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) I n f l a m m a t i o n                                         1 ( 2 % )                       I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 6 5 T A B L E   D 5 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N o n n e o p l a s t i c   L e s i o n s   i n   F e m a l e   M i c e   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) 2 - Y e a r   S t u d y   ( c o n t i n u e d ) A l i m e n t a r y   S y s t e m   ( c o n t i n u e d ) S t o m a c h ,   f o r e s t o m a c h ( 5 0 ) ( 4 9 ) ( 5 0 ) ( 5 0 ) E r o s i o n                                         2 ( 4 % )                       F o r e i g n   b o d y                                                           1 ( 2 % )     I n f l a m m a t i o n ,   c h r o n i c                                                           1 ( 2 % )     U l c e r                       2 ( 4 % )                                         E p i t h e l i u m ,   h y p e r p l a s i a     1 ( 2 % )         4 ( 8 % )         4 ( 8 % )         3 ( 6 % )     S t o m a c h ,   g l a n d u l a r ( 4 9 ) ( 4 9 ) ( 5 0 ) ( 4 9 ) I n f l a m m a t i o n ,   s u p p u r a t i v e     2 ( 4 % )                           1 ( 2 % )         1 ( 2 % )     N e c r o s i s ,   f o c a l                                                           1 ( 2 % )     E p i t h e l i u m ,   h y p e r p l a s i a                                         1 ( 2 % )                       T o o t h   ( 1 )           ( 2 )         I n f l a m m a t i o n                                         2 ( 1 0 0 % )                   M a l f o r m a t i o n     1 ( 1 0 0 % )                                                       C a r d i o v a s c u l a r   S y s t e m H e a r t ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) C a r d i o m y o p a t h y   4 5 ( 9 0 % )     3 9 ( 7 8 % )     4 6 ( 9 2 % )     3 8 ( 7 6 % )   M i n e r a l i z a t i o n                                         2 ( 4 % )                       N e c r o s i s                                                           1 ( 2 % )     A r t e r y ,   i n f l a m m a t i o n     1 ( 2 % )       1 6 ( 3 2 % )     1 1 ( 2 2 % )     1 3 ( 2 6 % )   A t r i u m ,   t h r o m b o s i s     1 ( 2 % )         1 ( 2 % )         1 ( 2 % )         1 ( 2 % )     E p i c a r d i u m ,   i n f l a m m a t i o n     1 ( 2 % )         5 ( 1 0 % )                         7 ( 1 4 % )   P e r i c a r d i u m ,   i n f l a m m a t i o n                       9 ( 1 8 % )                         4 ( 8 % )     V a l v e ,   i n f l a m m a t i o n                                         1 ( 2 % )                       V a l v e ,   t h r o m b o s i s     1 ( 2 % )                                                           E n d o c r i n e   S y s t e m A d r e n a l   c o r t e x ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) A m y l o i d   d e p o s i t i o n     2 ( 4 % )         1 ( 2 % )                           2 ( 4 % )     D e g e n e r a t i o n ,   c y s t i c     1 ( 2 % )                           1 ( 2 % )                       D e g e n e r a t i o n ,   f o c a l                                                           1 ( 2 % )     H e m a t o p o i e t i c   c e l l   p r o l i f e r a t i o n     1 ( 2 % )                           1 ( 2 % )                       H y p e r p l a s i a                                                           1 ( 2 % )     H y p e r t r o p h y     9 ( 1 8 % )       7 ( 1 4 % )       3 ( 6 % )       1 0 ( 2 0 % )   C a p s u l e ,   h y p e r p l a s i a                       1 ( 2 % )                                         A d r e n a l   m e d u l l a ( 4 9 ) ( 4 9 ) ( 5 0 ) ( 4 9 ) H y p e r p l a s i a     4 ( 8 % )         5 ( 1 0 % )       2 ( 4 % )         3 ( 6 % )     I s l e t s ,   p a n c r e a t i c ( 5 0 ) ( 4 9 ) ( 5 0 ) ( 5 0 ) H y p e r p l a s i a     2 ( 4 % )                           2 ( 4 % )         1 ( 2 % )     P a r a t h y r o i d   g l a n d ( 3 4 ) ( 3 1 ) ( 2 9 ) ( 3 0 ) H y p e r p l a s i a     1 ( 3 % )                                                           P i t u i t a r y   g l a n d ( 5 0 ) ( 5 0 ) ( 4 8 ) ( 4 9 ) P a r s   d i s t a l i s ,   h y p e r p l a s i a   1 6 ( 3 2 % )     1 5 ( 3 0 % )     2 1 ( 4 4 % )     1 5 ( 3 1 % )   P a r s   i n t e r m e d i a ,   h y p e r p l a s i a     1 ( 2 % )                                                           T h y r o i d   g l a n d ( 5 0 ) ( 4 9 ) ( 5 0 ) ( 4 9 ) I n f l a m m a t i o n ,   s u p p u r a t i v e                       2 ( 4 % )         4 ( 8 % )         1 ( 2 % )     F o l l i c l e ,   c y s t     1 ( 2 % )                                                           F o l l i c u l a r   c e l l ,   h y p e r p l a s i a     1 ( 2 % )                           2 ( 4 % )                       2 6 6 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   D 5 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N o n n e o p l a s t i c   L e s i o n s   i n   F e m a l e   M i c e   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) 2 - Y e a r   S t u d y   ( c o n t i n u e d ) G e n e r a l   B o d y   S y s t e m N o n e                                 G e n i t a l   S y s t e m O v a r y ( 4 7 ) ( 4 6 ) ( 4 4 ) ( 4 7 ) A n g i e c t a s i s     2 ( 4 % )         2 ( 4 % )                           1 ( 2 % )     C y s t   1 2 ( 2 6 % )       9 ( 2 0 % )     1 1 ( 2 5 % )       9 ( 1 9 % )   T h r o m b o s i s                       1 ( 2 % )         1 ( 2 % )         2 ( 4 % )     I n t e r s t i t i a l   c e l l ,   h y p e r p l a s i a     1 ( 2 % )         1 ( 2 % )         1 ( 2 % )         1 ( 2 % )     U t e r u s ( 5 0 ) ( 4 9 ) ( 5 0 ) ( 5 0 ) A n g i e c t a s i s     1 ( 2 % )         3 ( 6 % )         3 ( 6 % )         5 ( 1 0 % )   H y d r o m e t r a     8 ( 1 6 % )       8 ( 1 6 % )       8 ( 1 6 % )       5 ( 1 0 % )   H y p e r p l a s i a ,   c y s t i c   3 8 ( 7 6 % )     3 1 ( 6 3 % )     3 6 ( 7 2 % )     3 2 ( 6 4 % )   I n f l a m m a t i o n ,   s u p p u r a t i v e                       1 ( 2 % )         1 ( 2 % )         1 ( 2 % )     M i n e r a l i z a t i o n                       1 ( 2 % )                                         T h r o m b o s i s                                         1 ( 2 % )         2 ( 4 % )     H e m a t o p o i e t i c   S y s t e m B o n e   m a r r o w ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) F i b r o s i s     2 ( 4 % )                           1 ( 2 % )                       H y p e r p l a s i a     6 ( 1 2 % )     1 3 ( 2 6 % )       5 ( 1 0 % )       7 ( 1 4 % )   L y m p h   n o d e   ( 1 )   ( 5 )   ( 6 )   ( 8 ) I l i a c ,   a n g i e c t a s i s                       1 ( 2 0 % )                                       I l i a c ,   h e m a t o p o i e t i c   c e l l   p r o l i f e r a t i o n                                                           1 ( 1 3 % )   I l i a c ,   h y p e r p l a s i a                       1 ( 2 0 % )                         1 ( 1 3 % )   L u m b a r ,   a n g i e c t a s i s                                         1 ( 1 7 % )                     L u m b a r ,   h e m o r r h a g e                                         1 ( 1 7 % )                     L u m b a r ,   h y p e r p l a s i a                       1 ( 2 0 % )                         1 ( 1 3 % )   L u m b a r ,   i n f l a m m a t i o n ,   c h r o n i c                                         1 ( 1 7 % )                     R e n a l ,   a n g i e c t a s i s                                         1 ( 1 7 % )                     L y m p h   n o d e ,   b r o n c h i a l ( 3 6 ) ( 5 0 ) ( 4 8 ) ( 5 0 ) F o r e i g n   b o d y                     4 4 ( 8 8 % )     3 3 ( 6 9 % )     4 0 ( 8 0 % )   H e m a t o p o i e t i c   c e l l   p r o l i f e r a t i o n                                                           1 ( 2 % )     H y p e r p l a s i a     5 ( 1 4 % )     4 2 ( 8 4 % )     3 1 ( 6 5 % )     2 8 ( 5 6 % )   A r t e r y ,   i n f l a m m a t i o n                       2 ( 4 % )         1 ( 2 % )         1 ( 2 % )     L y m p h   n o d e ,   m a n d i b u l a r ( 3 6 ) ( 3 6 ) ( 4 3 ) ( 4 2 ) H e m a t o p o i e t i c   c e l l   p r o l i f e r a t i o n                                                           1 ( 2 % )     H y p e r p l a s i a                                                           1 ( 2 % )     L y m p h   n o d e ,   m e s e n t e r i c ( 4 8 ) ( 4 9 ) ( 5 0 ) ( 4 8 ) H e m a t o p o i e t i c   c e l l   p r o l i f e r a t i o n     1 ( 2 % )                                             1 ( 2 % )     H y p e r p l a s i a     8 ( 1 7 % )       6 ( 1 2 % )       7 ( 1 4 % )       7 ( 1 5 % )   I n f l a m m a t i o n ,   c h r o n i c   a c t i v e     1 ( 2 % )                                                           L y m p h   n o d e ,   m e d i a s t i n a l ( 4 2 ) ( 4 8 ) ( 4 6 ) ( 4 9 ) F o r e i g n   b o d y                     2 0 ( 4 2 % )       7 ( 1 5 % )     1 6 ( 3 3 % )   H e m a t o p o i e t i c   c e l l   p r o l i f e r a t i o n                                                           1 ( 2 % )     H y p e r p l a s i a     2 ( 5 % )       4 0 ( 8 3 % )     1 1 ( 2 4 % )     2 9 ( 5 9 % )   S p l e e n ( 5 0 ) ( 4 9 ) ( 5 0 ) ( 4 9 ) H e m a t o p o i e t i c   c e l l   p r o l i f e r a t i o n   1 6 ( 3 2 % )     3 6 ( 7 3 % )     2 6 ( 5 2 % )     2 1 ( 4 3 % )   H y p e r p l a s i a ,   l y m p h o i d   1 5 ( 3 0 % )       3 ( 6 % )       1 1 ( 2 2 % )     1 4 ( 2 9 % )   M e t a p l a s i a ,   o s s e o u s                                         1 ( 2 % )                       T h y m u s ( 4 7 ) ( 4 6 ) ( 4 2 ) ( 4 2 ) H y p e r p l a s i a ,   l y m p h o i d                       3 ( 7 % )         3 ( 7 % )         2 ( 5 % )     I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 6 7 T A B L E   D 5 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N o n n e o p l a s t i c   L e s i o n s   i n   F e m a l e   M i c e   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) 2 - Y e a r   S t u d y   ( c o n t i n u e d ) I n t e g u m e n t a r y   S y s t e m M a m m a r y   g l a n d ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) H y p e r p l a s i a     2 ( 4 % )         2 ( 4 % )         4 ( 8 % )         3 ( 6 % )     M e t a p l a s i a ,   s q u a m o u s                       1 ( 2 % )                                         S k i n ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) H y p e r p l a s i a                                                           1 ( 2 % )     I n f l a m m a t i o n ,   s u p p u r a t i v e                       2 ( 4 % )                           1 ( 2 % )     H a i r   f o l l i c l e ,   a t r o p h y                                                           1 ( 2 % )     S u b c u t a n e o u s   t i s s u e ,   a n g i e c t a s i s                       1 ( 2 % )                                         S u b c u t a n e o u s   t i s s u e ,   h e m o r r h a g e                                                           1 ( 2 % )     S u b c u t a n e o u s   t i s s u e ,   i n f l a m m a t i o n ,   c h r o n i c                       1 ( 2 % )         1 ( 2 % )         1 ( 2 % )     S u b c u t a n e o u s   t i s s u e ,   i n f l a m m a t i o n ,       c h r o n i c   a c t i v e     1 ( 2 % )                                                           M u s c u l o s k e l e t a l   S y s t e m B o n e ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) C y s t                       1 ( 2 % )                                         F i b r o u s   o s t e o d y s t r o p h y   1 1 ( 2 2 % )     1 4 ( 2 8 % )     1 4 ( 2 8 % )     1 6 ( 3 2 % )   I n f l a m m a t i o n ,   c h r o n i c                       1 ( 2 % )                                         M a x i l l a ,   f r a c t u r e                                                           1 ( 2 % )     N e r v o u s   S y s t e m B r a i n ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) M e n i n g e s ,   i n f i l t r a t i o n   c e l l u l a r ,       m o n o n u c l e a r   c e l l     2 ( 4 % )         2 ( 4 % )         2 ( 4 % )         2 ( 4 % )     R e s p i r a t o r y   S y s t e m L a r y n x ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) I n f l a m m a t i o n ,   s u p p u r a t i v e                       1 ( 2 % )         1 ( 2 % )         2 ( 4 % )     S q u a m o u s   e p i t h e l i u m ,   h y p e r p l a s i a     9 ( 1 8 % )     1 7 ( 3 4 % )     1 0 ( 2 0 % )     1 5 ( 3 0 % )   L u n g ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) F o r e i g n   b o d y                     4 9 ( 9 8 % )     3 5 ( 7 0 % )     4 9 ( 9 8 % )   H e m a t o p o i e t i c   c e l l   p r o l i f e r a t i o n                                                           1 ( 2 % )     H e m o r r h a g e     4 ( 8 % )         3 ( 6 % )         4 ( 8 % )         4 ( 8 % )     I n f l a m m a t i o n ,   c h r o n i c   a c t i v e     2 ( 4 % )       4 9 ( 9 8 % )     4 5 ( 9 0 % )     5 0 ( 1 0 0 % ) T h r o m b o s i s                                         1 ( 2 % )         1 ( 2 % )     A l v e o l a r   e p i t h e l i u m ,   h y p e r p l a s i a                       1 ( 2 % )         1 ( 2 % )         2 ( 4 % )     A l v e o l u s ,   i n f i l t r a t i o n   c e l l u l a r ,   h i s t i o c y t e                       2 ( 4 % )         2 ( 4 % )         3 ( 6 % )     A l v e o l u s ,   p r o t e i n o s i s                     3 1 ( 6 2 % )                         8 ( 1 6 % )   A r t e r y ,   i n f l a m m a t i o n                       1 ( 2 % )         1 ( 2 % )                       A r t e r y ,   m e d i a s t i n u m ,   i n f l a m m a t i o n                                         1 ( 2 % )                       B r o n c h i o l e ,   b r o n c h u s ,   d e g e n e r a t i o n ,   h y a l i n e                                                           2 ( 4 % )     I n t e r s t i t i u m ,   f i b r o s i s                       1 ( 2 % )                           2 ( 4 % )     M e d i a s t i n u m ,   i n f l a m m a t i o n ,   c h r o n i c   a c t i v e     1 ( 2 % )                                                           P e r i v a s c u l a r ,   i n f i l t r a t i o n   c e l l u l a r ,                                                                               m o n o n u c l e a r   c e l l     1 ( 2 % )                                                           S e r o s a ,   f i b r o s i s                     5 0 ( 1 0 0 % )   4 7 ( 9 4 % )     4 9 ( 9 8 % )   S e r o s a ,   m e t a p l a s i a ,   o s s e o u s                       1 ( 2 % )                                         2 6 8 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   D 5 S u m m a r y   o f   t h e   I n c i d e n c e   o f   N o n n e o p l a s t i c   L e s i o n s   i n   F e m a l e   M i c e   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 C o n t r o l ( S t o p - E x p o s u r e ) ( S t o p - E x p o s u r e ) 2 - Y e a r   S t u d y   ( c o n t i n u e d ) R e s p i r a t o r y   S y s t e m   ( c o n t i n u e d ) N o s e ( 5 0 ) ( 5 0 ) ( 5 0 ) ( 5 0 ) A n g i e c t a s i s     1 ( 2 % )                                                           I n f l a m m a t i o n ,   s u p p u r a t i v e     7 ( 1 4 % )       7 ( 1 4 % )       7 ( 1 4 % )       2 ( 4 % )     O l f a c t o r y   e p i t h e l i u m ,   a t r o p h y     6 ( 1 2 % )       1 ( 2 % )         3 ( 6 % )         2 ( 4 % )     O l f a c t o r y   e p i t h e l i u m ,   d e g e n e r a t i o n ,   h y a l i n e     3 ( 6 % )         3 ( 6 % )       1 0 ( 2 0 % )       2 ( 4 % )     R e s p i r a t o r y   e p i t h e l i u m ,   d e g e n e r a t i o n ,   h y a l i n e   2 8 ( 5 6 % )     1 7 ( 3 4 % )     2 7 ( 5 4 % )     1 4 ( 2 8 % )   R e s p i r a t o r y   e p i t h e l i u m ,   h y p e r p l a s i a                                         1 ( 2 % )                       P l e u r a         ( 1 6 )   ( 3 ) ( 1 3 ) M e s o t h e l i u m ,   h y p e r p l a s i a                     1 6 ( 1 0 0 % )       3 ( 1 0 0 % )   1 3 ( 1 0 0 % ) T r a c h e a ( 5 0 ) ( 4 8 ) ( 5 0 ) ( 5 0 ) D e g e n e r a t i o n ,   h y a l i n e                                                           1 ( 2 % )     I n f l a m m a t i o n ,   s u p p u r a t i v e     1 ( 2 % )                                                           S p e c i a l   S e n s e s   S y s t e m E y e                   ( 1 )         D e g e n e r a t i o n                                         1 ( 1 0 0 % )                   U r i n a r y   S y s t e m K i d n e y ( 5 0 ) ( 4 9 ) ( 5 0 ) ( 5 0 ) C y s t                                         1 ( 2 % )                       I n f l a m m a t i o n ,   c h r o n i c   a c t i v e     1 ( 2 % )                                                           M e t a p l a s i a ,   o s s e o u s     2 ( 4 % )         3 ( 6 % )         4 ( 8 % )         2 ( 4 % )     N e p h r o p a t h y   3 7 ( 7 4 % )     3 0 ( 6 1 % )     4 3 ( 8 6 % )     3 6 ( 7 2 % )   A r t e r y ,   i n f l a m m a t i o n                                         1 ( 2 % )         3 ( 6 % )     G l o m e r u l u s ,   i n f l a m m a t i o n ,   c h r o n i c                                                           1 ( 2 % )     R e n a l   t u b u l e ,   k a r y o m e g a l y                                         1 ( 2 % )                       U r i n a r y   b l a d d e r ( 4 8 ) ( 4 9 ) ( 4 9 ) ( 4 8 ) A n g i e c t a s i s     2 ( 4 % )         1 ( 2 % )         3 ( 6 % )         2 ( 4 % )     2 6 9 A P P E N D I X   E G E N E T I C   T O X I C O L O G Y M O U S E   P E R I P H E R A L   B L O O D   M I C R O N U C L E U S   T E S T   P R O T O C O L . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 7 0 E V A L U A T I O N   P R O T O C O L . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 7 0 R E S U L T S . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 7 1 T A B L E   E 1         F r e q u e n c y   o f   M i c r o n u c l e i   i n   P e r i p h e r a l   B l o o d   E r y t h r o c y t e s   o f   M i c e F o l l o w i n g   T r e a t m e n t   w i t h   I n d i u m   P h o s p h i d e   b y   I n h a l a t i o n   f o r   1 4   W e e k s . . . . . . . . . . . . . . 2 7 2 2 7 0 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 G E N E T I C   T O X I C O L O G Y M O U S E   P E R I P H E R A L   B L O O D   M I C R O N U C L E U S   T E S T   P R O T O C O L A   d e t a i l e d   d i s c u s s i o n   o f   t h i s   a s s a y   i s   p r e s e n t e d   b y   M a c G r e g o r   e t   a l .   ( 1 9 9 0 ) .     A t   t h e   e n d   o f   t h e   1 4 - w e e k   s t u d y , p e r i p h e r a l   b l o o d   s a m p l e s   w e r e   o b t a i n e d   f r o m   m a l e   a n d   f e m a l e   m i c e .     S m e a r s   w e r e   i m m e d i a t e l y   p r e p a r e d   a n d f i x e d   i n   a b s o l u t e   m e t h a n o l .     T h e   m e t h a n o l - f i x e d   s l i d e s   w e r e   s t a i n e d   w i t h   a c r i d i n e   o r a n g e   ( T i c e   e t   a l . ,   1 9 9 0 ) a n d   c o d e d .     S l i d e s   w e r e   s c a n n e d   t o   d e t e r m i n e   t h e   f r e q u e n c y   o f   m i c r o n u c l e i   i n   1 , 0 0 0   p o l y c h r o m a t i c e r y t h r o c y t e s   ( P C E s )   a n d   1 , 0 0 0   n o r m o c h r o m a t i c   e r y t h r o c y t e s   ( N C E s )   i n   u p   t o   1 0   a n i m a l s   p e r   e x p o s u r e   g r o u p .   T h e   r e s u l t s   w e r e   t a b u l a t e d   a s   t h e   m e a n   o f   t h e   p o o l e d   r e s u l t s   f r o m   a l l   a n i m a l s   w i t h i n   a   t r e a t m e n t   g r o u p   p l u s   o r m i n u s   t h e   s t a n d a r d   e r r o r   o f   t h e   m e a n .     T h e   f r e q u e n c y   o f   m i c r o n u c l e a t e d   c e l l s   a m o n g   N C E s   a n d   P C E s   w a s a n a l y z e d   b y   a   s t a t i s t i c a l   s o f t w a r e   p a c k a g e   t h a t   t e s t e d   f o r   i n c r e a s i n g   t r e n d   o v e r   e x p o s u r e   g r o u p s   w i t h   a   o n e - t a i l e d   C o c h r a n - A r m i t a g e   t r e n d   t e s t ,   f o l l o w e d   b y   p a i r w i s e   c o m p a r i s o n s   b e t w e e n   e a c h   e x p o s u r e   g r o u p   a n d   t h e c o n t r o l   g r o u p   ( I L S ,   1 9 9 0 ) .     I n   t h e   p r e s e n c e   o f   e x c e s s   b i n o m i a l   v a r i a t i o n ,   a s   d e t e c t e d   b y   a   b i n o m i a l   d i s p e r s i o n t e s t ,   t h e   b i n o m i a l   v a r i a n c e   o f   t h e   C o c h r a n - A r m i t a g e   t e s t   w a s   a d j u s t e d   u p w a r d   i n   p r o p o r t i o n   t o   t h e   e x c e s s v a r i a t i o n .     I n   t h e   m i c r o n u c l e u s   t e s t ,   a n   i n d i v i d u a l   t r i a l   i s   c o n s i d e r e d   p o s i t i v e   i f   t h e   t r e n d   t e s t   P   v a l u e   i s   l e s s   t h a n o r   e q u a l   t o   0 . 0 2 5   o r   i f   t h e   P   v a l u e   f o r   a n y   s i n g l e   e x p o s e d   g r o u p   i s   l e s s   t h a n   o r   e q u a l   t o   0 . 0 2 5   d i v i d e d   b y   t h e n u m b e r   o f   e x p o s u r e   g r o u p s .     A   f i n a l   c a l l   o f   p o s i t i v e   f o r   m i c r o n u c l e u s   i n d u c t i o n   i s   p r e f e r a b l y   b a s e d   o n r e p r o d u c i b l y   p o s i t i v e   t r i a l s   ( a s   n o t e d   a b o v e ) .     R e s u l t s   o f   t h e   1 4 - w e e k   s t u d i e s   w e r e   a c c e p t e d   w i t h o u t   r e p e a t t e s t s ,   b e c a u s e   a d d i t i o n a l   t e s t   d a t a   c o u l d   n o t   b e   o b t a i n e d .     U l t i m a t e l y ,   t h e   f i n a l   c a l l   i s   d e t e r m i n e d   b y   t h e s c i e n t i f i c   s t a f f   a f t e r   c o n s i d e r i n g   t h e   r e s u l t s   o f   s t a t i s t i c a l   a n a l y s e s ,   t h e   r e p r o d u c i b i l i t y   o f   a n y   e f f e c t s   o b s e r v e d , a n d   t h e   m a g n i t u d e s   o f   t h o s e   e f f e c t s . E V A L U A T I O N   P R O T O C O L T h e s e   a r e   t h e   b a s i c   g u i d e l i n e s   f o r   a r r i v i n g   a t   a n   o v e r a l l   a s s a y   r e s u l t   f o r   a s s a y s   p e r f o r m e d   b y   t h e   N a t i o n a l T o x i c o l o g y   P r o g r a m .     S t a t i s t i c a l   a s   w e l l   a s   b i o l o g i c a l   f a c t o r s   a r e   c o n s i d e r e d .     F o r   a n   i n d i v i d u a l   a s s a y ,   t h e s t a t i s t i c a l   p r o c e d u r e s   f o r   d a t a   a n a l y s i s   h a v e   b e e n   d e s c r i b e d   i n   t h e   p r e c e d i n g   p r o t o c o l .     T h e r e   h a v e   b e e n i n s t a n c e s ,   h o w e v e r ,   i n   w h i c h   m u l t i p l e   a l i q u o t s   o f   a   c h e m i c a l   w e r e   t e s t e d   i n   t h e   s a m e   a s s a y ,   a n d   d i f f e r e n t r e s u l t s   w e r e   o b t a i n e d   a m o n g   a l i q u o t s   a n d / o r   a m o n g   l a b o r a t o r i e s .     R e s u l t s   f r o m   m o r e   t h a n   o n e   a l i q u o t   o r   f r o m m o r e   t h a n   o n e   l a b o r a t o r y   a r e   n o t   s i m p l y   c o m b i n e d   i n t o   a n   o v e r a l l   r e s u l t .     R a t h e r ,   a l l   t h e   d a t a   a r e   c r i t i c a l l y e v a l u a t e d ,   p a r t i c u l a r l y   w i t h   r e g a r d   t o   p e r t i n e n t   p r o t o c o l   v a r i a t i o n s ,   i n   d e t e r m i n i n g   t h e   w e i g h t   o f   e v i d e n c e   f o r a n   o v e r a l l   c o n c l u s i o n   o f   c h e m i c a l   a c t i v i t y   i n   a n   a s s a y .     I n   a d d i t i o n   t o   m u l t i p l e   a l i q u o t s ,   t h e   i n   v i t r o   a s s a y s   h a v e a n o t h e r   v a r i a b l e   t h a t   m u s t   b e   c o n s i d e r e d   i n   a r r i v i n g   a t   a n   o v e r a l l   t e s t   r e s u l t .     I n   v i t r o   a s s a y s   a r e   c o n d u c t e d   w i t h a n d   w i t h o u t   e x o g e n o u s   m e t a b o l i c   a c t i v a t i o n .     R e s u l t s   o b t a i n e d   i n   t h e   a b s e n c e   o f   a c t i v a t i o n   a r e   n o t   c o m b i n e d w i t h   r e s u l t s   o b t a i n e d   i n   t h e   p r e s e n c e   o f   a c t i v a t i o n ;   e a c h   t e s t i n g   c o n d i t i o n   i s   e v a l u a t e d   s e p a r a t e l y .     T h e s u m m a r y   t a b l e   i n   t h e   A b s t r a c t   o f   t h i s   T e c h n i c a l   R e p o r t   p r e s e n t s   a   r e s u l t   t h a t   r e p r e s e n t s   a   s c i e n t i f i c   j u d g e m e n t o f   t h e   o v e r a l l   e v i d e n c e   f o r   a c t i v i t y   o f   t h e   c h e m i c a l   i n   a n   a s s a y .   I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 7 1 R E S U L T S B l o o d   s a m p l e s   f r o m   f e m a l e   m i c e   e x p o s e d   t o   i n d i u m   p h o s p h i d e   f o r   1 4   w e e k s   b y   i n h a l a t i o n   s h o w e d   n o s i g n i f i c a n t   i n c r e a s e   i n   t h e   f r e q u e n c y   o f   m i c r o n u c l e a t e d   N C E s   ( T a b l e   E 1 ) .     A l s o   i n   f e m a l e   m i c e ,   a n a l y s i s   o f m i c r o n u c l e u s   f r e q u e n c i e s   i n   P C E s   i n   t h e   3 0   m g / m 3   g r o u p   w a s   c o n s i s t e n t   w i t h   t h e   l a c k   o f   e f f e c t   s e e n   i n   t h e N C E   p o p u l a t i o n .     I n   m a l e   m i c e ,   t h e   t r e n d   a n a l y s i s   s h o w e d   a   s m a l l   b u t   n o n s i g n i f i c a n t   ( P = 0 . 0 5 4 )   c o n c e n t r a t i o n - r e l a t e d   i n c r e a s e   i n   t h e   f r e q u e n c y   o f   N C E s ;   a   g r e a t e r   e f f e c t   w a s   o b s e r v e d   i n   P C E s ,   w h e r e   a   s i g n i f i c a n t   i n c r e a s e ( P = 0 . 0 1 0 8 )   i n   t h e   n u m b e r   o f   m i c r o n u c l e i   w a s   o b s e r v e d   i n   t h e   3 0   m g / m 3   g r o u p   ( T a b l e   E 1 ) .     T h e   P C E   d a t a   f o r t h e   m a l e   m i c e   m a y   i n d i c a t e   a   r e c e n t   i n d u c t i o n   o f   g e n e t i c   d a m a g e   t h a t   w a s   r a p i d l y   e l i m i n a t e d   o r   r e d u c e d   i n   t h e m a t u r e   N C E   p o p u l a t i o n ,   p r e v e n t i n g   t h e   a c c u m u l a t i o n   o f   d a m a g e d   m a t u r e   e r y t h r o c y t e s   w i t h   r e p e a t e d   e x p o s u r e .   T h e   f a c t   t h a t   s i m i l a r   e f f e c t s   w e r e   n o t   s e e n   i n   f e m a l e   m i c e   i s   r e a s o n   t o   b e   c a u t i o u s   i n   i n t e r p r e t i n g   t h e   e f f e c t s o b s e r v e d   i n   m a l e   m i c e .     I n   n e i t h e r   g e n d e r   w a s   t h e   p e r c e n t a g e   o f   P C E s   a l t e r e d . 2 7 2 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   E 1 F r e q u e n c y   o f   M i c r o n u c l e i   i n   P e r i p h e r a l   B l o o d   E r y t h r o c y t e s   o f   M i c e   F o l l o w i n g   T r e a t m e n t w i t h   I n d i u m   P h o s p h i d e   b y   I n h a l a t i o n   f o r   1 4   W e e k s a E x p o s u r e N u m b e r   o f   M i c e M i c r o n u c l e a t e d   C e l l s / 1 , 0 0 0   C e l l s b C o n c e n t r a t i o n w i t h   E r y t h r o c y t e s P C E s   ( % ) ( m g / m 3 ) S c o r e d N C E s c P C E s M a l e C h a m b e r   C o n t r o l 1 0 1 . 5 0   ±   0 . 2 7 1 . 7 0   ±   0 . 4 2 2 . 7 3 1 9 1 . 6 7   ±   0 . 3 7 — d 2 . 8 9 3 1 0 2 . 4 0   ±   0 . 4 3 — 2 . 5 6 1 0 9 1 . 8 9   ±   0 . 3 5 — 2 . 3 0 3 0 9 2 . 7 8   ±   0 . 2 2 4 . 1 1   ±   0 . 6 8 * 2 . 4 6 P = 0 . 0 5 4 e F e m a l e C h a m b e r   C o n t r o l 1 0 1 . 1 0   ±   0 . 3 1 0 . 9 0   ±   0 . 3 5 2 . 5 2 1 1 0 1 . 3 0   ±   0 . 3 3 — 2 . 4 8 3 1 0 1 . 1 0   ±   0 . 3 1 — 2 . 2 4 1 0 1 0 1 . 3 0   ±   0 . 2 1 — 2 . 1 2 3 0 6 1 . 6 7   ±   0 . 5 5 1 . 3 3   ±   0 . 3 3 2 . 7 0 P = 0 . 1 7 7 * S i g n i f i c a n t l y   d i f f e r e n t   ( P = 0 . 0 1 0 8 )   f r o m   t h e   c h a m b e r   c o n t r o l   b y   p a i r w i s e   c o m p a r i s o n   ( I L S ,   1 9 9 0 ) a S t u d y   w a s   p e r f o r m e d   a t   I n t e g r a t e d   L a b o r a t o r y   S y s t e m s ,   I n c .     T h e   d e t a i l e d   p r o t o c o l   i s   p r e s e n t e d   b y   M a c G r e g o r   e t   a l .   ( 1 9 9 0 ) .   N C E = n o r m o c h r o m a t i c   e r y t h r o c y t e ;   P C E = p o l y c h r o m a t i c   e r y t h r o c y t e b M e a n   ±   s t a n d a r d   e r r o r c D i f f e r e n c e s   f r o m   t h e   c h a m b e r   c o n t r o l   g r o u p   w e r e   n o t   s i g n i f i c a n t   b y   p a i r w i s e   c o m p a r i s o n ,   s i g n i f i c a n t   a t   P # 0 . 0 0 6   ( I L S ,   1 9 9 0 ) . d N o t   s c o r e d e S i g n i f i c a n c e   o f   m i c r o n u c l e a t e d   N C E s / 1 , 0 0 0   N C E s   t e s t e d   b y   t h e   o n e - t a i l e d   C o c h r a n - A r m i t a g e   t r e n d   t e s t ,   s i g n i f i c a n t   a t   P # 0 . 0 2 5   ( I L S ,   1 9 9 0 ) 2 7 3 A P P E N D I X   F C L I N I C A L   P A T H O L O G Y   R E S U L T S T A B L E   F 1 H e m a t o l o g y ,   C l i n i c a l   C h e m i s t r y ,   a n d   U r i n a l y s i s   D a t a   f o r   R a t s   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 7 4 T A B L E   F 2 H e m a t o l o g y   a n d   C l i n i c a l   C h e m i s t r y   D a t a   f o r   R a t s   a t   t h e   3 - M o n t h   I n t e r i m   E v a l u a t i o n i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 8 0 T A B L E   F 3 H e m a t o l o g y   D a t a   f o r   M i c e   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . 2 8 2 T A B L E   F 4 H e m a t o l o g y   a n d   C l i n i c a l   C h e m i s t r y   D a t a   f o r   M i c e   a t   t h e   3 - M o n t h   I n t e r i m   E v a l u a t i o n i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 8 3 2 7 4 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   F 1 H e m a t o l o g y ,   C l i n i c a l   C h e m i s t r y ,   a n d   U r i n a l y s i s   D a t a   f o r   R a t s   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e a C h a m b e r   C o n t r o l 1   m g / m 3 3   m g / m 3 1 0   m g / m 3 3 0   m g / m 3 1 0 0   m g / m 3 M a l e H e m a t o l o g y n D a y   3 1 0 1 0 1 0 1 0 1 0 1 0 D a y   2 3 1 0 1 0 1 0 1 0 1 0 1 0 W e e k   1 4 1 0 1 0 1 0 1 0 1 0     9 M a n u a l   h e m a t o c r i t   ( % )   D a y   3 4 7 . 2   ±   0 . 4 4 7 . 5   ±   0 . 4 4 7 . 4   ±   0 . 4 4 7 . 0   ±   0 . 4 4 7 . 5   ±   0 . 4 4 7 . 0   ±   0 . 4       D a y   2 3 5 1 . 7   ±   0 . 3 5 3 . 2   ±   0 . 4 5 3 . 1   ±   0 . 6 * 5 2 . 7   ±   0 . 3 5 3 . 5   ±   0 . 3 * * 5 3 . 0   ±   0 . 3       W e e k   1 4 4 7 . 0   ±   0 . 3 4 9 . 6   ±   0 . 2 * * 5 1 . 4   ±   0 . 4 * * 5 0 . 4   ±   0 . 3 * * 5 0 . 5   ±   0 . 5 * * 5 5 . 3   ±   1 . 6 * *         A u t o m a t e d   h e m a t o c r i t   ( % )   D a y   3 4 4 . 6   ±   0 . 3 4 5 . 1   ±   0 . 5 4 4 . 8   ±   0 . 4 4 4 . 4   ±   0 . 4 4 5 . 5   ±   0 . 5 4 5 . 0   ±   0 . 4   D a y   2 3 4 9 . 5   ±   0 . 2 5 2 . 0   ±   0 . 4 * * 5 1 . 3   ±   0 . 5 * 5 1 . 1   ±   0 . 2 * 5 2 . 5   ±   0 . 4 * * 5 1 . 1   ±   0 . 2 *   W e e k   1 4 4 5 . 4   ±   0 . 4 4 8 . 1   ±   0 . 3 * * 4 9 . 5   ±   0 . 4 * * 4 9 . 3   ±   0 . 5 * * 4 9 . 7   ±   0 . 7 * * 5 4 . 0   ±   1 . 7 * * H e m o g l o b i n   ( g / d L )   D a y   3 1 4 . 9   ±   0 . 1 1 5 . 3   ±   0 . 1 1 5 . 1   ±   0 . 2 1 4 . 9   ±   0 . 1 1 5 . 2   ±   0 . 1 1 5 . 0   ±   0 . 1 D a y   2 3 1 6 . 7   ±   0 . 1 1 7 . 5   ±   0 . 1 * * 1 7 . 4   ±   0 . 1 * * 1 7 . 3   ±   0 . 1 * 1 7 . 7   ±   0 . 2 * * 1 7 . 2   ±   0 . 1 W e e k   1 4 1 5 . 2   ±   0 . 2 1 6 . 3   ±   0 . 1 * * 1 7 . 0   ±   0 . 2 * * 1 6 . 6   ±   0 . 2 * * 1 6 . 5   ±   0 . 2 * * 1 6 . 6   ±   0 . 4 * * E r y t h r o c y t e s   ( 1 0 6 / µ L   )   D a y   3 7 . 0 6   ±   0 . 0 8 7 . 1 7   ±   0 . 1 0 7 . 1 7   ±   0 . 1 1 7 . 1 1   ±   0 . 0 8 7 . 2 5   ±   0 . 0 9 7 . 2 4   ±   0 . 1 0   D a y   2 3 7 . 9 7   ±   0 . 0 5 8 . 4 1   ±   0 . 0 7 * * 8 . 2 7   ±   0 . 1 0 * * 8 . 2 5   ±   0 . 0 4 * * 8 . 4 8   ±   0 . 0 7 * * 8 . 2 9   ±   0 . 0 5 * *   W e e k   1 4 8 . 3 4   ±   0 . 0 9 8 . 8 3   ±   0 . 0 6 * * 9 . 2 5   ±   0 . 0 7 * * 9 . 3 7   ±   0 . 1 0 * * 9 . 7 5   ±   0 . 1 5 * * 1 0 . 5 2   ±   0 . 1 3 * *   R e t i c u l o c y t e s   ( 1 0 6 / µ L   )   D a y   3 0 . 3 5   ±   0 . 0 4 0 . 2 5   ±   0 . 0 2 0 . 2 6   ±   0 . 0 4 0 . 1 7   ±   0 . 0 2 * * 0 . 2 1   ±   0 . 0 2 * * 0 . 1 7   ±   0 . 0 3 * *   D a y   2 3 0 . 1 3   ±   0 . 0 2 0 . 1 2   ±   0 . 0 2 0 . 1 2   ±   0 . 0 2 0 . 1 4   ±   0 . 0 2 0 . 1 3   ±   0 . 0 2 0 . 1 1   ±   0 . 0 1   W e e k   1 4 0 . 1 0   ±   0 . 0 1 0 . 0 8   ±   0 . 0 1 0 . 0 9   ±   0 . 0 1 0 . 0 9   ±   0 . 0 1 0 . 1 2   ±   0 . 0 2 0 . 4 4   ±   0 . 0 5 * *   N u c l e a t e d   e r y t h r o c y t e s / 1 0 0   l e u k o c y t e s   D a y   3 1 . 2 0   ±   0 . 3 9 1 . 5 0   ±   0 . 4 5 0 . 7 0   ±   0 . 3 4 0 . 6 0   ±   0 . 2 7 1 . 7 0   ±   0 . 4 7 0 . 9 0   ±   0 . 4 1   D a y   2 3 0 . 2 0   ±   0 . 1 3 0 . 2 0   ±   0 . 1 3 0 . 5 0   ±   0 . 2 2 0 . 2 0   ±   0 . 1 3 0 . 0 0   ±   0 . 0 0 0 . 3 0   ±   0 . 1 5   W e e k   1 4 0 . 8 0   ±   0 . 2 0 0 . 5 0   ±   0 . 1 7 0 . 4 0   ±   0 . 2 2 0 . 2 0   ±   0 . 2 0 0 . 3 0   ±   0 . 1 5 8 . 4 4   ±   3 . 3 6   M e a n   c e l l   v o l u m e   ( f L )   D a y   3 6 3 . 1   ±   0 . 4 6 2 . 9   ±   0 . 3 6 2 . 6   ±   0 . 3 6 2 . 4   ±   0 . 4 6 2 . 8   ±   0 . 4 6 2 . 1   ±   0 . 3   D a y   2 3 6 2 . 1   ±   0 . 3 6 1 . 9   ±   0 . 3 6 2 . 3   ±   0 . 3 6 2 . 0   ±   0 . 2 6 2 . 0   ±   0 . 3 6 1 . 7   ±   0 . 3   W e e k   1 4 5 4 . 3   ±   0 . 3 5 4 . 5   ±   0 . 2 5 3 . 6   ±   0 . 2 5 2 . 5   ±   0 . 2 * * 5 0 . 9   ±   0 . 2 * * 5 1 . 2   ±   1 . 0 * * M e a n   c e l l   h e m o g l o b i n   ( p g )   D a y   3 2 1 . 1   ±   0 . 1 2 1 . 3   ±   0 . 1 2 1 . 0   ±   0 . 2 2 1 . 0   ±   0 . 1 2 0 . 9   ±   0 . 2 2 0 . 8   ±   0 . 2   D a y   2 3 2 1 . 0   ±   0 . 1 2 0 . 8   ±   0 . 1 2 1 . 0   ±   0 . 1 2 0 . 9   ±   0 . 1 2 0 . 8   ±   0 . 1 2 0 . 8   ±   0 . 2   W e e k   1 4 1 8 . 3   ±   0 . 1 1 8 . 5   ±   0 . 1 1 8 . 3   ±   0 . 1 1 7 . 7   ±   0 . 1 * * 1 6 . 9   ±   0 . 1 * * 1 5 . 8   ±   0 . 2 * *   M e a n   c e l l   h e m o g l o b i n   c o n c e n t r a t i o n   ( g / d L )   D a y   3 3 3 . 4   ±   0 . 2 3 3 . 9   ±   0 . 1 3 3 . 6   ±   0 . 2 3 3 . 6   ±   0 . 2 3 3 . 3   ±   0 . 2 3 3 . 4   ±   0 . 3   D a y   2 3 3 3 . 8   ±   0 . 1 3 3 . 6   ±   0 . 2 3 3 . 9   ±   0 . 1 3 3 . 7   ±   0 . 1 3 3 . 6   ±   0 . 1 3 3 . 7   ±   0 . 1   W e e k   1 4 3 3 . 6   ±   0 . 2 3 4 . 0   ±   0 . 2 3 4 . 2   ±   0 . 2 3 3 . 6   ±   0 . 1 3 3 . 1   ±   0 . 2 3 0 . 8   ±   0 . 3 * * P l a t e l e t s   ( 1 0 3 / µ L   )     D a y   3 1 , 0 3 8 . 2   ±   1 6 . 4 1 , 0 0 8 . 0   ±   1 7 . 3 1 , 0 0 4 . 3   ±   1 7 . 4 1 , 0 5 9 . 2   ±   1 6 . 4 9 9 7 . 4   ±   2 5 . 3 1 , 0 1 9 . 3   ±   1 6 . 5   D a y   2 3 7 5 5 . 8   ±   1 1 . 0 7 3 5 . 4   ±   1 2 . 2 6 9 8 . 5   ±   1 0 . 5 * * 7 3 0 . 4   ±   1 0 . 8 * 6 5 9 . 2   ±   1 1 . 9 * * 6 6 0 . 2   ±   1 1 . 6 * *   W e e k   1 4 6 1 4 . 3   ±   7 . 4 6 2 0 . 3   ±   1 0 . 4 5 8 7 . 2   ±   8 . 6 5 7 1 . 2   ±   6 . 3 5 2 0 . 5   ±   1 1 . 5 * * 7 3 7 . 2   ±   3 4 . 7   L e u k o c y t e s   ( 1 0 3 / µ L   )     D a y   3 1 0 . 5 5   ±   0 . 5 4 1 1 . 7 8   ±   0 . 4 6 1 0 . 4 3   ±   0 . 7 5 1 0 . 2 2   ±   0 . 6 1 9 . 6 8   ±   0 . 4 7 1 0 . 1 9   ±   0 . 5 6   D a y   2 3 1 2 . 2 4   ±   0 . 2 7 1 1 . 2 1   ±   0 . 2 6 * 1 0 . 5 5   ±   0 . 4 0 * * 1 0 . 5 8   ±   0 . 4 2 * * 1 0 . 2 2   ±   0 . 4 3 * * 9 . 2 5   ±   0 . 4 2 * *   W e e k   1 4 5 . 8 7   ±   0 . 2 9 6 . 1 4   ±   0 . 3 2 6 . 6 3   ±   0 . 3 4 7 . 6 1   ±   0 . 4 4 * * 7 . 9 5   ±   0 . 2 7 * * 8 . 2 3   ±   0 . 6 2 * *   I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 7 5 T A B L E   F 1 H e m a t o l o g y ,   C l i n i c a l   C h e m i s t r y ,   a n d   U r i n a l y s i s   D a t a   f o r   R a t s   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r   C o n t r o l 1   m g / m 3 3   m g / m 3 1 0   m g / m 3 3 0   m g / m 3 1 0 0   m g / m 3 M a l e   ( c o n t i n u e d ) H e m a t o l o g y   ( c o n t i n u e d ) n D a y   3 1 0 1 0 1 0 1 0 1 0 1 0 D a y   2 3 1 0 1 0 1 0 1 0 1 0 1 0 W e e k   1 4 1 0 1 0 1 0 1 0 1 0     9 S e g m e n t e d   n e u t r o p h i l s   ( 1 0 3 / µ L   )   D a y   3 1 . 0 2   ±   0 . 0 7 2 . 0 1   ±   0 . 2 3 * * 1 . 3 9   ±   0 . 0 8 1 . 1 0   ±   0 . 1 6 0 . 1 0   ±   0 . 1 0 1 . 3 0   ±   0 . 1 1   D a y   2 3 1 . 2 7   ±   0 . 1 3 1 . 8 0   ±   0 . 1 9 1 . 8 6   ±   0 . 2 2 1 . 6 9   ±   0 . 1 3 1 . 8 8   ±   0 . 1 4 * 1 . 8 2   ±   0 . 1 4   W e e k   1 4 1 . 2 2   ±   0 . 1 8 1 . 8 5   ±   0 . 1 3 * 2 . 0 6   ±   0 . 1 3 * * 2 . 1 3   ±   0 . 1 4 * * 2 . 2 0   ±   0 . 1 3 * * 3 . 1 2   ±   0 . 3 1 * *   B a n d s   ( 1 0 3 / µ L   )   D a y   3 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0   D a y   2 3 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0   W e e k   1 4 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0   L y m p h o c y t e s   ( 1 0 3 / µ L   )   D a y   3 9 . 4 1   ±   0 . 5 1 9 . 6 5   ±   0 . 3 6 8 . 9 6   ±   0 . 7 2 8 . 9 6   ±   0 . 4 7 8 . 5 8   ±   0 . 4 2 8 . 7 5   ±   0 . 5 5   D a y   2 3 1 0 . 8 9   ±   0 . 2 4 9 . 3 2   ±   0 . 2 6 * * 8 . 5 8   ±   0 . 3 3 * * 8 . 8 2   ±   0 . 3 7 * * 8 . 2 6   ±   0 . 3 6 * * 7 . 3 6   ±   0 . 3 8 * *   W e e k   1 4 4 . 4 5   ±   0 . 2 4 4 . 1 0   ±   0 . 2 4 4 . 4 0   ±   0 . 2 8 5 . 3 5   ±   0 . 4 3 5 . 5 9   ±   0 . 2 8 * 4 . 9 0   ±   0 . 4 0   M o n o c y t e s   ( 1 0 3 / µ L   )   D a y   3 0 . 0 4   ±   0 . 0 2 0 . 1 1   ±   0 . 0 5 0 . 0 4   ±   0 . 0 3 0 . 1 3   ±   0 . 0 9 0 . 0 6   ±   0 . 0 3 0 . 0 7   ±   0 . 0 3   D a y   2 3 0 . 0 4   ±   0 . 0 3 0 . 0 6   ±   0 . 0 2 0 . 0 5   ±   0 . 0 3 0 . 0 1   ±   0 . 0 1 0 . 0 4   ±   0 . 0 3 0 . 0 2   ±   0 . 0 1   W e e k   1 4 0 . 1 5   ±   0 . 0 4 0 . 1 2   ±   0 . 0 3 0 . 1 7   ±   0 . 0 4 0 . 1 1   ±   0 . 0 3 0 . 1 6   ±   0 . 0 3 0 . 2 0   ±   0 . 0 5   B a s o p h i l s   ( 1 0 3 / µ L   )   D a y   3 0 . 0 1 3   ±   0 . 0 1 3 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0   D a y   2 3 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0   W e e k   1 4 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0   E o s i n o p h i l s   ( 1 0 3 / µ L   )   D a y   3 0 . 0 6   ±   0 . 0 3 0 . 0 1   ±   0 . 0 1 0 . 0 4   ±   0 . 0 3 0 . 0 2   ±   0 . 0 2 0 . 0 4   ±   0 . 0 2 0 . 0 6   ±   0 . 0 2   D a y   2 3 0 . 0 5   ±   0 . 0 3 0 . 0 3   ±   0 . 0 2 0 . 0 6   ±   0 . 0 2 0 . 0 6   ±   0 . 0 2 0 . 0 5   ±   0 . 0 2 0 . 0 5   ±   0 . 0 3   W e e k   1 4 0 . 0 5   ±   0 . 0 2 0 . 0 3   ±   0 . 0 1 0 . 0 0   ±   0 . 0 0 0 . 0 2   ±   0 . 0 1 0 . 0 0   ±   0 . 0 0 0 . 0 1   ±   0 . 0 1   C l i n i c a l   C h e m i s t r y n D a y   3 1 0 1 0 1 0 1 0 1 0 1 0 D a y   2 3 1 0 1 0 1 0 1 0 1 0 1 0 W e e k   1 4 1 0 1 0 1 0 1 0 1 0     9 U r e a   n i t r o g e n   ( m g / d L )   D a y   3 1 4 . 9   ±   0 . 7 1 4 . 0   ±   0 . 3 1 4 . 2   ±   0 . 5 1 3 . 8   ±   0 . 6 1 2 . 4   ±   0 . 6 * 1 4 . 3   ±   0 . 5   D a y   2 3 1 4 . 7   ±   0 . 3 1 4 . 5   ±   0 . 4 1 5 . 1   ±   0 . 6 1 4 . 0   ±   0 . 5 1 4 . 6   ±   0 . 3 1 3 . 0   ±   0 . 4 *   W e e k   1 4 1 8 . 9   ±   0 . 3 2 0 . 5   ±   1 . 0 1 7 . 9   ±   0 . 3 2 0 . 2   ±   0 . 3 * 2 0 . 5   ±   0 . 6 * 3 6 . 7   ±   3 . 9 * *   C r e a t i n i n e   ( m g / d L )   D a y   3 0 . 6 5   ±   0 . 0 2 0 . 6 8   ±   0 . 0 3 0 . 6 6   ±   0 . 0 2 0 . 6 0   ±   0 . 0 2 0 . 6 1   ±   0 . 0 1 0 . 6 7   ±   0 . 0 3 D a y   2 3 0 . 7 6   ±   0 . 0 2   0 . 7 6   ±   0 . 0 2 0 . 7 6   ±   0 . 0 2 0 . 7 4   ±   0 . 0 2 0 . 7 4   ±   0 . 0 3 0 . 7 2   ±   0 . 0 2             W e e k   1 4 0 . 9 2   ±   0 . 0 2 0 . 9 6   ±   0 . 0 2 0 . 9 3   ±   0 . 0 2 0 . 9 1   ±   0 . 0 2 0 . 8 7   ±   0 . 0 3 0 . 6 9   ±   0 . 0 3 * * T o t a l   p r o t e i n   ( g / d L )   D a y   3 6 . 0   ±   0 . 0 6 . 0   ±   0 . 1 6 . 1   ±   0 . 1 5 . 8   ±   0 . 0 6 . 1   ±   0 . 1 6 . 1   ±   0 . 1   D a y   2 3 6 . 6   ±   0 . 1 6 . 6   ±   0 . 1 6 . 7   ±   0 . 1 6 . 6   ±   0 . 0 6 . 6   ±   0 . 1 6 . 5   ±   0 . 1   W e e k   1 4 7 . 5   ±   0 . 1 7 . 4   ±   0 . 1 7 . 4   ±   0 . 5 7 . 4   ±   0 . 1 7 . 5   ±   0 . 1 5 . 7   ±   0 . 1 * * 2 7 6 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   F 1 H e m a t o l o g y ,   C l i n i c a l   C h e m i s t r y ,   a n d   U r i n a l y s i s   D a t a   f o r   R a t s   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r   C o n t r o l 1   m g / m 3 3   m g / m 3 1 0   m g / m 3 3 0   m g / m 3 1 0 0   m g / m 3 M a l e   ( c o n t i n u e d ) C l i n i c a l   c h e m i s t r y   ( c o n t i n u e d ) n D a y   3 1 0 1 0 1 0 1 0 1 0 1 0 D a y   2 3 1 0 1 0 1 0 1 0 1 0 1 0 W e e k   1 4 1 0 1 0 1 0 1 0 1 0     9 A l b u m i n   ( g / d L )   D a y   3 3 . 7   ±   0 . 1 3 . 6   ±   0 . 1 3 . 6   ±   0 . 1 3 . 7   ±   0 . 1 3 . 6   ±   0 . 1 3 . 9   ±   0 . 1   D a y   2 3 3 . 8   ±   0 . 0 3 . 7   ±   0 . 0 3 . 8   ±   0 . 1 3 . 8   ±   0 . 0 3 . 8   ±   0 . 1 3 . 8   ±   0 . 0   W e e k   1 4 4 . 4   ±   0 . 0 4 . 4   ±   0 . 1 4 . 3   ±   0 . 1 4 . 4   ±   0 . 1 4 . 3   ±   0 . 1 2 . 5   ±   0 . 1 * *   G l o b u l i n   ( g / d L )   D a y   3 2 . 4   ±   0 . 1 2 . 5   ±   0 . 2 2 . 5   ±   0 . 1 2 . 2   ±   0 . 1 2 . 5   ±   0 . 1 2 . 2   ±   0 . 1   D a y   2 3 2 . 8   ±   0 . 0 2 . 9   ±   0 . 1 2 . 9   ±   0 . 1 2 . 8   ±   0 . 0 2 . 9   ±   0 . 1 2 . 8   ±   0 . 0   W e e k   1 4 3 . 1   ±   0 . 1 3 . 0   ±   0 . 1 3 . 0   ±   0 . 1 3 . 1   ±   0 . 1 3 . 2   ±   0 . 1 3 . 1   ±   0 . 1   A / G   r a t i o   D a y   3 1 . 6   ±   0 . 2 1 . 5   ±   0 . 2 1 . 5   ±   0 . 1 1 . 8   ±   0 . 1 1 . 5   ±   0 . 1 1 . 8   ±   0 . 1   D a y   2 3 1 . 4   ±   0 . 0 1 . 3   ±   0 . 0 1 . 3   ±   0 . 0 1 . 3   ±   0 . 0 1 . 4   ±   0 . 1 1 . 4   ±   0 . 0   W e e k   1 4 1 . 5   ±   0 . 1 1 . 5   ±   0 . 1 1 . 5   ±   0 . 1 1 . 4   ±   0 . 1 1 . 4   ±   0 . 0 0 . 8   ±   0 . 1 * * A l a n i n e   a m i n o t r a n s f e r a s e   ( I U / L )   D a y   3 3 6   ±   1 3 6   ±   1 3 8   ±   1 3 5   ±   1 3 7   ±   1 3 7   ±   1   D a y   2 3 3 5   ±   1 4 0   ±   2 4 1   ±   3 3 8   ±   1 4 0   ±   1 * 4 0   ±   1   W e e k   1 4 5 3   ±   2 6 7   ±   4 * * 7 6   ±   7 * * 8 6   ±   7 * * 1 0 5   ±   7 * * 1 9 5   ±   2 6 * *   C r e a t i n e   k i n a s e   ( I U / L )   D a y   3 2 9 3   ±   3 3 3 5 8   ±   5 5 3 0 3   ±   2 5 2 8 2   ±   3 1 4 2 2   ±   9 8 3 5 2   ±   4 6   D a y   2 3 3 7 5   ±   2 2 2 3 6   ±   1 7 * * 4 1 2   ±   5 5 2 8 4   ±   3 7 * 3 2 8   ±   3 4 2 7 1   ±   1 8 *   W e e k   1 4 1 2 2   ±   1 5 1 3 6   ±   1 0 1 4 9   ±   2 1 1 3 5   ±   1 3 9 6   ±   5 1 2 5   ±   9   A l k a l i n e   p h o s p h a t a s e   ( I U / L )   D a y   3 6 6 0   ±   1 2 6 6 1   ±   1 6 6 6 6   ±   1 4 6 4 2   ±   1 3 6 7 1   ±   1 4 6 5 6   ±   1 8   D a y   2 3 4 3 7   ±   1 1 4 7 3   ±   1 1 4 5 5   ±   9 4 4 9   ±   1 2 4 6 4   ±   8 4 5 8   ±   8   W e e k   1 4 3 1 0   ±   6 3 2 8   ±   5 2 9 2   ±   6 3 1 1   ±   7 3 7 9   ±   1 0 * * 3 2 6   ±   1 5   S o r b i t o l   d e h y d r o g e n a s e   ( I U / L )   D a y   3 1 4   ±   0 1 5   ±   1 1 4   ±   0 1 4   ±   0 1 4   ±   0 1 4   ±   1   D a y   2 3 1 4   ±   1 1 7   ±   1 1 6   ±   1 1 8   ±   1 1 7   ±   1 1 6   ±   1   W e e k   1 4 2 1   ±   0 2 7   ±   2 * * 2 6   ±   2 * * 2 8   ±   2 * * 3 3   ±   2 * * 4 3   ±   4 * *   B i l e   a c i d s   ( µ m o l / L )   D a y   3 3 0 . 7   ±   1 . 0 3 3 . 9   ±   3 . 0 3 3 . 9   ±   2 . 6 2 9 . 8   ±   1 . 9 3 6 . 7   ±   3 . 7 3 4 . 8   ±   3 . 2   D a y   2 3 3 9 . 9   ±   7 . 7 3 2 . 7   ±   2 . 4 4 1 . 1   ±   6 . 4 2 9 . 5   ±   1 . 0 3 3 . 6   ±   1 . 7 3 3 . 4   ±   3 . 6   W e e k   1 4 2 3 . 4   ±   0 . 9 2 2 . 8   ±   0 . 6 2 3 . 4   ±   2 . 1 2 2 . 5   ±   0 . 7 b 2 3 . 2   ±   0 . 7 4 1 . 3   ±   5 . 7 U r i n a l y s i s n 1 0 1 0 1 0 1 0 1 0 1 0 C r e a t i n i n e   ( m g / d L )   3 4 . 7 0   ±   8 . 6 3 2 9 . 6 0   ±   2 . 4 3 2 8 . 3 0   ±   2 . 1 8 2 8 . 6 0   ±   1 . 8 4 2 3 . 4 0   ±   2 . 4 9 2 4 . 7 0   ±   3 . 3 6   G l u c o s e   ( m g / m g   c r e a t i n i n e )   0 . 1 7   ±   0 . 0 2 0 . 1 2   ±   0 . 0 1 0 . 1 1   ±   0 . 0 1 * 0 . 1 4   ±   0 . 0 2 0 . 1 2   ±   0 . 0 1 0 . 1 1   ±   0 . 0 1 *   P r o t e i n   ( m g / m g   c r e a t i n i n e )   2 . 0   ±   0 . 1 1 . 9   ±   0 . 1 1 . 9   ±   0 . 0 1 . 9   ±   0 . 1 2 . 0   ±   0 . 0 1 . 9   ±   0 . 1   A l k a l i n e   p h o s p h a t a s e     ( U / m g   c r e a t i n i n e ) 0 . 4 4   ±   0 . 0 2 0 . 4 9   ±   0 . 0 2 0 . 5 3   ±   0 . 0 2 0 . 4 6   ±   0 . 0 2 0 . 5 3   ±   0 . 0 2 0 . 4 5   ±   0 . 0 2 A s p a r t a t e   a m i n o t r a n s f e r a s e       ( m U / m g   c r e a t i n i n e ) 1 1 . 9   ±   1 . 3 1 5 . 0   ±   1 . 6 1 2 . 6   ±   1 . 0 1 1 . 9   ±   0 . 8 1 1 . 1   ±   1 . 3 1 2 . 0   ±   1 . 3     I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 7 7 T A B L E   F 1 H e m a t o l o g y ,   C l i n i c a l   C h e m i s t r y ,   a n d   U r i n a l y s i s   D a t a   f o r   R a t s   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r   C o n t r o l 1   m g / m 3 3   m g / m 3 1 0   m g / m 3 3 0   m g / m 3 1 0 0   m g / m 3 M a l e   ( c o n t i n u e d ) U r i n a l y s i s   ( c o n t i n u e d )   n 1 0 1 0 1 0 1 0 1 0 1 0 L a c t a t e   d e h y d r o g e n a s e     ( m U / m g   c r e a t i n i n e ) 5 9 . 5   ±   4 . 1 5 3 . 9   ±   4 . 1 5 6 . 8   ±   2 . 6 5 1 . 8   ±   3 . 7 5 7 . 5   ±   4 . 8 4 8 . 2   ±   5 . 5   ( - G l u t a m y l t r a n s f e r a s e     ( U / m g   c r e a t i n i n e ) 2 . 9   ±   0 . 1 3 . 0   ±   0 . 1 3 . 1   ±   0 . 1 3 . 1   ±   0 . 1 3 . 3   ±   0 . 1 2 . 9   ±   0 . 1   N - a c e t y l - $ - D - g l u c o s a m i n i d a s e     ( m U / m g   c r e a t i n i n e ) 1 6 . 6   ±   0 . 6 1 7 . 6   ±   0 . 6 1 7 . 8   ±   0 . 9 1 6 . 0   ±   0 . 5 1 7 . 6   ±   0 . 6 1 7 . 4   ±   0 . 9   V o l u m e   ( m L / 1 6   h r )   2 4 . 2   ±   3 . 0 2 3 . 2   ±   2 . 1 2 2 . 1   ±   1 . 8 2 2 . 1   ±   1 . 6 2 6 . 6   ±   3 . 0 2 5 . 3   ±   2 . 7   S p e c i f i c   g r a v i t y   1 . 0 1 2   ±   0 . 0 0 3 1 . 0 1 0   ±   0 . 0 0 1 1 . 0 0 9   ±   0 . 0 0 1 1 . 0 0 9   ±   0 . 0 0 1 1 . 0 0 8   ±   0 . 0 0 1 1 . 0 0 8   ±   0 . 0 0 1   p H 7 . 0 0   ±   0 . 1 1 7 . 1 5   ±   0 . 1 3 7 . 1 5   ±   0 . 1 1 7 . 0 0   ±   0 . 0 8 7 . 2 2   ±   0 . 1 2 7 . 5 5   ±   0 . 1 4 * F e m a l e H e m a t o l o g y n 1 0 1 0 1 0 1 0 1 0 1 0 M a n u a l   h e m a t o c r i t   ( % )   D a y   3 5 0 . 5   ±   0 . 6 4 8 . 9   ±   0 . 5 4 8 . 7   ±   0 . 6 4 8 . 6   ±   0 . 5 4 9 . 2   ±   0 . 7 4 9 . 3   ±   0 . 5   D a y   2 3 5 0 . 6   ±   0 . 7 5 2 . 0   ±   0 . 2 * 5 1 . 6   ±   0 . 3 5 1 . 9   ±   0 . 4 5 2 . 6   ±   0 . 4 * * 5 3 . 2   ±   0 . 3 * *   W e e k   1 4 4 6 . 0   ±   0 . 4 4 8 . 5   ±   0 . 4 * * 4 9 . 4   ±   0 . 5 * * 5 0 . 6   ±   0 . 5 * * 5 0 . 4   ±   0 . 4 * * 4 8 . 4   ±   1 . 4 * *   A u t o m a t e d   h e m a t o c r i t   ( % )   D a y   3 4 8 . 7   ±   0 . 7 4 6 . 7   ±   0 . 4 4 6 . 5   ±   0 . 7 4 6 . 2   ±   0 . 5 * 4 7 . 3   ±   0 . 6 4 7 . 4   ±   0 . 5   D a y   2 3 5 0 . 4   ±   0 . 5 5 2 . 1   ±   0 . 4 * * 5 2 . 0   ±   0 . 4 * 5 1 . 8   ±   0 . 4 * 5 2 . 8   ±   0 . 4 * * 5 3 . 2   ±   0 . 3 * *   W e e k   1 4 4 5 . 0   ±   0 . 3 4 7 . 3   ±   0 . 5 * * 4 8 . 0   ±   0 . 3 * * 4 9 . 7   ±   0 . 3 * * 4 9 . 3   ±   0 . 3 * * 4 8 . 4   ±   1 . 3 * *   H e m o g l o b i n   ( g / d L )   D a y   3 1 6 . 2   ±   0 . 2 1 5 . 9   ±   0 . 1 1 5 . 7   ±   0 . 2 1 5 . 6   ±   0 . 2 1 6 . 0   ±   0 . 2 1 6 . 1   ±   0 . 2   D a y   2 3 1 7 . 1   ±   0 . 2 1 7 . 7   ±   0 . 1 * 1 7 . 8   ±   0 . 2 * 1 7 . 7   ±   0 . 1 * 1 8 . 0   ±   0 . 1 * * 1 8 . 1   ±   0 . 1 * *   W e e k   1 4 1 5 . 6   ±   0 . 1 1 6 . 5   ±   0 . 1 1 6 . 6   ±   0 . 2 * 1 7 . 2   ±   0 . 1 * * 1 6 . 9   ±   0 . 1 * * 1 5 . 3   ±   0 . 3   E r y t h r o c y t e s   ( 1 0 6 / µ L )   D a y   3 7 . 8 4   ±   0 . 1 3 7 . 5 6   ±   0 . 0 8 7 . 6 5   ±   0 . 1 3 7 . 4 5   ±   0 . 1 3 7 . 6 9   ±   0 . 0 9 7 . 7 9   ±   0 . 1 0   D a y   2 3 8 . 1 4   ±   0 . 0 9 8 . 3 4   ±   0 . 0 6 8 . 3 3   ±   0 . 0 6 8 . 3 3   ±   0 . 1 0 8 . 5 6   ±   0 . 0 9 * * 8 . 5 3   ±   0 . 0 8 * *   W e e k   1 4 7 . 7 7   ±   0 . 0 7 8 . 0 8   ±   0 . 0 8 * 8 . 2 7   ±   0 . 0 6 * * 8 . 6 9   ±   0 . 0 6 * * 8 . 7 1   ±   0 . 0 7 * * 1 0 . 2 6   ±   0 . 1 9 * *   R e t i c u l o c y t e s   ( 1 0 6 / µ L )   D a y   3 0 . 1 1   ±   0 . 0 1 0 . 1 1   ±   0 . 0 1 0 . 1 2   ±   0 . 0 1 0 . 1 3   ±   0 . 0 1 0 . 1 1   ±   0 . 0 1 0 . 0 9   ±   0 . 0 1   D a y   2 3 0 . 0 7   ±   0 . 0 1 0 . 0 9   ±   0 . 0 2 0 . 1 1   ±   0 . 0 2 0 . 0 8   ±   0 . 0 1 0 . 0 6   ±   0 . 0 0 0 . 0 7   ±   0 . 0 1   W e e k   1 4 0 . 0 8   ±   0 . 0 1 0 . 0 5   ±   0 . 0 1 0 . 0 5   ±   0 . 0 1 0 . 0 8   ±   0 . 0 1 0 . 1 0   ±   0 . 0 1 0 . 3 6   ±   0 . 0 9 * *   N u c l e a t e d   e r y t h r o c y t e s / 1 0 0   l e u k o c y t e s   D a y   3 0 . 3 0   ±   0 . 1 5 0 . 2 0   ±   0 . 2 0 0 . 4 0   ±   0 . 2 2 0 . 6 0   ±   0 . 3 4 1 . 3 0   ±   0 . 5 0 0 . 3 0   ±   0 . 1 5   D a y   2 3 0 . 1 0   ±   0 . 1 0 0 . 1 0   ±   0 . 1 0 0 . 4 0   ±   0 . 2 2 0 . 1 0   ±   0 . 1 0 0 . 2 0   ±   0 . 1 3 0 . 2 0   ±   0 . 1 3   W e e k   1 4 0 . 5 0   ±   0 . 4 0 0 . 0 0   ±   0 . 0 0 0 . 3 0   ±   0 . 1 5 0 . 1 0   ±   0 . 1 0 0 . 1 0   ±   0 . 1 0 5 . 8 0   ±   2 . 8 8 *   M e a n   c e l l   v o l u m e   ( f L ) D a y   3 6 2 . 1   ±   0 . 3 6 1 . 6   ±   0 . 2 6 0 . 9   ±   0 . 3 * 6 1 . 9   ±   0 . 5 6 1 . 5   ±   0 . 3 6 0 . 9   ±   0 . 3 * D a y   2 3 6 1 . 8   ±   0 . 4 6 2 . 5   ±   0 . 3 6 2 . 5   ±   0 . 3 6 2 . 2   ±   0 . 4 6 1 . 8   ±   0 . 3 6 2 . 4   ±   0 . 3 W e e k   1 4 5 8 . 1   ±   0 . 2 5 8 . 5   ±   0 . 2 5 7 . 9   ±   0 . 2 5 7 . 1   ±   0 . 2 * * 5 6 . 6   ±   0 . 4 * * 4 7 . 2   ±   0 . 7 * * 2 7 8 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   F 1 H e m a t o l o g y ,   C l i n i c a l   C h e m i s t r y ,   a n d   U r i n a l y s i s   D a t a   f o r   R a t s   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r   C o n t r o l 1   m g / m 3 3   m g / m 3 1 0   m g / m 3 3 0   m g / m 3 1 0 0   m g / m 3 F e m a l e   ( c o n t i n u e d ) H e m a t o l o g y   ( c o n t i n u e d ) n 1 0 1 0 1 0 1 0 1 0 1 0 M e a n   c e l l   h e m o g l o b i n   ( p g )   D a y   3 2 0 . 7   ±   0 . 1 2 1 . 0   ±   0 . 1 2 0 . 6   ±   0 . 1 2 1 . 0   ±   0 . 2 2 0 . 8   ±   0 . 2 2 0 . 7   ±   0 . 1   D a y   2 3 2 1 . 1   ±   0 . 1 2 1 . 2   ±   0 . 1 2 1 . 4   ±   0 . 1 2 1 . 3   ±   0 . 2 2 1 . 0   ±   0 . 1 2 1 . 1   ±   0 . 1   W e e k   1 4 2 0 . 1   ±   0 . 1 2 0 . 3   ±   0 . 1 2 0 . 1   ±   0 . 1 1 9 . 8   ±   0 . 1 1 9 . 4   ±   0 . 2 * * 1 4 . 9   ±   0 . 2 * *   M e a n   c e l l   h e m o g l o b i n   c o n c e n t r a t i o n   ( g / d L )   D a y   3 3 3 . 3   ±   0 . 2 3 4 . 0   ±   0 . 2 3 3 . 8   ±   0 . 2 3 3 . 8   ±   0 . 2 3 3 . 7   ±   0 . 2 3 4 . 0   ±   0 . 2   D a y   2 3 3 3 . 9   ±   0 . 1 3 3 . 9   ±   0 . 1 3 4 . 2   ±   0 . 2 3 4 . 2   ±   0 . 1 3 4 . 0   ±   0 . 2 3 3 . 9   ±   0 . 1   W e e k   1 4 3 4 . 7   ±   0 . 2 3 4 . 8   ±   0 . 2 3 4 . 6   ±   0 . 1 3 4 . 6   ±   0 . 2 3 4 . 3   ±   0 . 2 3 1 . 7   ±   0 . 2 * *   P l a t e l e t s   ( 1 0 3 / µ L )   D a y   3 1 0 2 2 . 2   ±   2 0 . 7 1 0 2 3 . 6   ±   3 1 . 3 1 0 2 5 . 6   ±   2 1 . 1 1 0 0 8 . 1   ±   3 8 . 2 1 0 1 1 . 0   ±   3 5 . 3 9 9 8 . 8   ±   3 1 . 8   D a y   2 3 6 6 4 . 4   ±   3 4 . 6 6 9 8 . 5   ±   1 2 . 9 6 5 9 . 2   ±   2 0 . 8 7 1 3 . 7   ±   1 6 . 7 6 4 1 . 8   ±   1 8 . 4 6 6 5 . 4   ±   1 6 . 1   W e e k   1 4 5 6 6 . 3   ±   1 9 . 3 5 9 0 . 9   ±   1 1 . 2 5 5 6 . 4   ±   2 1 . 9 5 5 5 . 4   ±   1 4 . 3 5 5 9 . 4   ±   3 5 . 2 4 9 5 . 3   ±   3 0 . 5 *   L e u k o c y t e s   ( 1 0 3 / µ L )   D a y   3 1 3 . 0 8   ±   0 . 4 0 1 2 . 4 4   ±   0 . 4 5 1 1 . 3 5   ±   0 . 5 8 * 1 1 . 3 7   ±   0 . 5 4 * 1 0 . 5 6   ±   0 . 2 6 * * 1 2 . 2 2   ±   0 . 6 7 *   D a y   2 3 1 1 . 2 5   ±   0 . 6 3 1 0 . 8 1   ±   0 . 4 9 9 . 9 5   ±   0 . 4 0 1 0 . 6 9   ±   0 . 4 0 9 . 4 5   ±   0 . 3 9 * 9 . 2 9   ±   0 . 3 6 * *   W e e k   1 4 6 . 7 3   ±   0 . 5 2 6 . 0 1   ±   0 . 2 9 6 . 4 1   ±   0 . 2 3 6 . 3 0   ±   0 . 3 4 7 . 8 8   ±   0 . 2 9 * 9 . 4 5   ±   1 . 0 9 *   S e g m e n t e d   n e u t r o p h i l s   ( 1 0 3 / µ L )   D a y   3 0 . 9 2   ±   0 . 0 8 1 . 7 2   ±   0 . 1 5 * * 1 . 1 3   ±   0 . 1 7 1 . 0 7   ±   0 . 1 2 1 . 3 3   ±   0 . 1 5 1 . 3 2   ±   0 . 1 6   D a y   2 3 1 . 0 3   ±   0 . 1 7 1 . 2 8   ±   0 . 1 3 1 . 1 7   ±   0 . 1 3 1 . 3 9   ±   0 . 1 2 1 . 0 9   ±   0 . 0 9 1 . 5 0   ±   0 . 1 7   W e e k   1 4 1 . 2 0   ±   0 . 1 7 1 . 6 8   ±   0 . 0 9 * 1 . 5 3   ±   0 . 1 2 1 . 8 4   ±   0 . 1 3 * * 2 . 2 6   ±   0 . 1 9 * * 3 . 8 4   ±   0 . 6 3 * *   B a n d s   ( 1 0 3 / µ L )   D a y   3 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0   D a y   2 3 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0   W e e k   1 4 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0   L y m p h o c y t e s   ( 1 0 3 / µ L )   D a y   3 1 2 . 0 0   ±   0 . 3 8 1 0 . 6 3   ±   0 . 4 7 1 0 . 1 5   ±   0 . 6 2 * 1 0 . 2 5   ±   0 . 4 8 * * 9 . 1 1   ±   0 . 2 0 * * 1 0 . 7 4   ±   0 . 7 1 * *   D a y   2 3 1 0 . 0 1   ±   0 . 6 3 9 . 1 3   ±   0 . 4 9 8 . 5 5   ±   0 . 4 0 9 . 0 2   ±   0 . 4 7 8 . 1 8   ±   0 . 4 0 * 7 . 4 3   ±   0 . 4 0 * *   W e e k   1 4 5 . 3 9   ±   0 . 4 6 4 . 1 5   ±   0 . 2 6 4 . 7 1   ±   0 . 1 7 4 . 3 9   ±   0 . 2 4 5 . 4 3   ±   0 . 1 6 5 . 5 2   ±   0 . 5 5   M o n o c y t e s   ( 1 0 3 / µ L )   D a y   3 0 . 0 8   ±   0 . 0 3 0 . 0 2   ±   0 . 0 2 0 . 0 1   ±   0 . 0 1 0 . 0 6   ±   0 . 0 4 0 . 0 5   ±   0 . 0 4 0 . 0 7   ±   0 . 0 4   D a y   2 3 0 . 1 5   ±   0 . 0 4 0 . 3 4   ±   0 . 0 8 0 . 1 7   ±   0 . 0 4 0 . 2 4   ±   0 . 0 8 0 . 1 6   ±   0 . 0 4 0 . 2 7   ±   0 . 0 6   W e e k   1 4 0 . 0 9   ±   0 . 0 3 0 . 1 5   ±   0 . 0 3 0 . 1 2   ±   0 . 0 2 0 . 0 4   ±   0 . 0 2 0 . 1 3   ±   0 . 0 4 0 . 0 8   ±   0 . 0 4   B a s o p h i l s   ( 1 0 3 / µ L )   D a y   3 0 . 0 2 8   ±   0 . 0 1 9 0 . 0 3 9   ±   0 . 0 2 0 0 . 0 0 8   ±   0 . 0 0 8 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 2 2   ±   0 . 0 2 2 0 . 0 0 9   ±   0 . 0 0 9   D a y   2 3 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0   W e e k   1 4 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0   E o s i n o p h i l s   ( 1 0 3 / µ L )   D a y   3 0 . 0 7   ±   0 . 0 2 0 . 0 3   ±   0 . 0 2 0 . 0 5   ±   0 . 0 2 0 . 0 0   ±   0 . 0 0 0 . 0 6   ±   0 . 0 3 0 . 0 8   ±   0 . 0 4   D a y   2 3 0 . 0 6   ±   0 . 0 3 0 . 0 6   ±   0 . 0 3 0 . 0 6   ±   0 . 0 2 0 . 0 4   ±   0 . 0 2 0 . 0 2   ±   0 . 0 1 0 . 0 9   ±   0 . 0 3   W e e k   1 4 0 . 0 6   ±   0 . 0 1 0 . 0 3   ±   0 . 0 1 0 . 0 5   ±   0 . 0 2 0 . 0 3   ±   0 . 0 1 0 . 0 5   ±   0 . 0 2 0 . 0 0   ±   0 . 0 0 * *   I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 7 9 T A B L E   F 1 H e m a t o l o g y ,   C l i n i c a l   C h e m i s t r y ,   a n d   U r i n a l y s i s   D a t a   f o r   R a t s   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r   C o n t r o l 1   m g / m 3 3   m g / m 3 1 0   m g / m 3 3 0   m g / m 3 1 0 0   m g / m 3 F e m a l e   ( c o n t i n u e d ) C l i n i c a l   C h e m i s t r y   n 1 0 1 0 1 0 1 0 1 0 1 0 U r e a   n i t r o g e n   ( m g / d L )   D a y   3 1 6 . 6   ±   0 . 5 1 7 . 6   ±   0 . 5 1 5 . 0   ±   0 . 6 1 5 . 5   ±   0 . 6 1 5 . 4   ±   0 . 8 1 6 . 2   ±   0 . 6   D a y   2 3 1 3 . 8   ±   0 . 4 1 3 . 3   ±   0 . 3 1 3 . 5   ±   0 . 4 1 2 . 9   ±   0 . 3 1 3 . 4   ±   1 . 0 1 3 . 4   ±   0 . 5 W e e k   1 4 2 0 . 7   ±   0 . 6 2 0 . 2   ±   0 . 5 2 0 . 4   ±   0 . 5 1 8 . 7   ±   0 . 4 1 9 . 0   ±   0 . 8 3 1 . 2   ±   2 . 2 * C r e a t i n i n e   ( m g / d L )   D a y   3 0 . 6 2   ±   0 . 0 1 0 . 6 0   ±   0 . 0 0 0 . 6 1   ±   0 . 0 2 0 . 6 0   ±   0 . 0 0 0 . 5 9   ±   0 . 0 2 b 0 . 6 2   ±   0 . 0 1   D a y   2 3 0 . 7 0   ±   0 . 0 3 0 . 7 2   ±   0 . 0 2 0 . 6 9   ±   0 . 0 1 0 . 6 8   ±   0 . 0 1 0 . 6 2   ±   0 . 0 1 * 0 . 6 8   ±   0 . 0 1   W e e k   1 4 0 . 8 9   ±   0 . 0 3 0 . 9 2   ±   0 . 0 3 0 . 8 7   ±   0 . 0 3 0 . 8 2   ±   0 . 0 3 0 . 8 2   ±   0 . 0 1 0 . 6 6   ±   0 . 0 2 * *   T o t a l   p r o t e i n   ( g / d L )   D a y   3 6 . 0   ±   0 . 1 6 . 0   ±   0 . 1 6 . 0   ±   0 . 1 6 . 0   ±   0 . 1 6 . 0   ±   0 . 0 6 . 0   ±   0 . 1   D a y   2 3 6 . 2   ±   0 . 1 6 . 2   ±   0 . 0 6 . 3   ±   0 . 1 6 . 3   ±   0 . 1 6 . 2   ±   0 . 1 6 . 4   ±   0 . 1 *   W e e k   1 4 7 . 5   ±   0 . 1 7 . 4   ±   0 . 1 7 . 5   ±   0 . 1 7 . 3   ±   0 . 1 7 . 1   ±   0 . 1 * 6 . 1   ±   0 . 1 * *   A l b u m i n   ( g / d L )   D a y   3 3 . 8   ±   0 . 1 3 . 8   ±   0 . 1 3 . 7   ±   0 . 1 3 . 9   ±   0 . 0 3 . 8   ±   0 . 1 3 . 8   ±   0 . 1   D a y   2 3 3 . 7   ±   0 . 0 3 . 8   ±   0 . 0 3 . 8   ±   0 . 1 3 . 9   ±   0 . 1 3 . 8   ±   0 . 0 3 . 8   ±   0 . 0   W e e k   1 4 4 . 3   ±   0 . 1 4 . 2   ±   0 . 1 4 . 4   ±   0 . 1 4 . 2   ±   0 . 1 4 . 1   ±   0 . 1 3 . 1   ±   0 . 1 * *   G l o b u l i n   ( g / d L )   D a y   3 2 . 2   ±   0 . 1 2 . 2   ±   0 . 1 2 . 3   ±   0 . 1 2 . 1   ±   0 . 0 2 . 2   ±   0 . 1 2 . 2   ±   0 . 1   D a y   2 3 2 . 4   ±   0 . 1 2 . 5   ±   0 . 1 2 . 5   ±   0 . 0 2 . 4   ±   0 . 1 2 . 4   ±   0 . 1 2 . 6   ±   0 . 1   W e e k   1 4 3 . 2   ±   0 . 1 3 . 2   ±   0 . 1 3 . 1   ±   0 . 1 3 . 1   ±   0 . 1 3 . 0   ±   0 . 1 3 . 1   ±   0 . 1   A / G   r a t i o   D a y   3 1 . 8   ±   0 . 1 1 . 8   ±   0 . 1 1 . 7   ±   0 . 1 1 . 9   ±   0 . 1 1 . 7   ±   0 . 1 1 . 8   ±   0 . 1   D a y   2 3 1 . 5   ±   0 . 0 1 . 6   ±   0 . 0 1 . 5   ±   0 . 0 1 . 6   ±   0 . 1 1 . 6   ±   0 . 0 1 . 5   ±   0 . 1   W e e k   1 4 1 . 4   ±   0 . 1 1 . 3   ±   0 . 0 1 . 4   ±   0 . 0 1 . 4   ±   0 . 1 1 . 4   ±   0 . 0 1 . 0   ±   0 . 1 * *   A l a n i n e   a m i n o t r a n s f e r a s e   ( I U / L )   D a y   3 3 5   ±   1 3 6   ±   2 3 5   ±   1 3 5   ±   1 3 6   ±   1 3 3   ±   1   D a y   2 3 2 8   ±   1 2 8   ±   2 3 2   ±   2 2 8   ±   1 3 0   ±   1 3 6   ±   2 * *   W e e k   1 4 4 9   ±   2 b 4 9   ±   3 5 1   ±   2 6 4   ±   5 * 8 4   ±   8 * * 2 8 9   ±   6 8 * *   A l k a l i n e   p h o s p h a t a s e   ( I U / L )   D a y   3 5 3 9   ±   1 5 5 3 6   ±   9 5 4 4   ±   9 5 5 0   ±   1 8 5 3 9   ±   1 5 5 2 1   ±   1 9   D a y   2 3 3 2 1   ±   1 2 3 3 0   ±   8 3 3 0   ±   8 3 1 5   ±   5 3 3 0   ±   6 3 6 0   ±   1 2 *   W e e k   1 4 2 7 7   ±   7 2 7 3   ±   1 0 2 8 4   ±   8 2 6 7   ±   1 2 3 6 5   ±   1 4 * * 4 0 8   ±   2 1 * *   C r e a t i n e   k i n a s e   ( I U / L )   D a y   3 3 5 9   ±   6 4 3 4 3   ±   3 1 2 8 0   ±   4 5 3 0 6   ±   5 7 2 2 5   ±   2 0 * * b 2 4 2   ±   2 7 *   D a y   2 3 3 1 8   ±   3 5 3 0 5   ±   2 0 4 0 2   ±   1 0 7 3 0 5   ±   1 0 2 3 9   ±   2 7 3 0 8   ±   1 7   W e e k   1 4 1 8 5   ±   3 9 2 0 4   ±   3 7 1 2 8   ±   2 7 1 3 0   ±   2 3 1 0 6   ±   9 1 9 6   ±   2 0   S o r b i t o l   d e y h d r o g e n a s e   ( I U / L )   D a y   3 1 5   ±   1 1 4   ±   0 1 4   ±   0 1 5   ±   0 1 4   ±   0 1 5   ±   0   D a y   2 3 1 7   ±   1 1 6   ±   1 1 7   ±   1 1 7   ±   1 1 8   ±   1 1 8   ±   1   W e e k   1 4 1 9   ±   1 b 2 0   ±   1 2 0   ±   1 2 2   ±   2 3 0   ±   3 * 4 3   ±   7 * *   B i l e   a c i d s   ( µ m o l / L )   D a y   3 2 1 . 0   ±   0 . 9 2 5 . 4   ±   2 . 4 2 4 . 5   ±   3 . 3 2 4 . 4   ±   2 . 2 2 2 . 5   ±   1 . 8 b 2 2 . 7   ±   1 . 4   D a y   2 3 2 7 . 0   ±   3 . 8 2 6 . 2   ±   5 . 8 2 8 . 4   ±   5 . 4 2 8 . 0   ±   5 . 8 2 7 . 0   ±   2 . 8 2 9 . 8   ±   3 . 9   W e e k   1 4 3 4 . 4   ±   7 . 2 2 3 . 2   ±   3 . 1 2 6 . 2   ±   5 . 6 1 9 . 9   ±   2 . 0 1 9 . 2   ±   1 . 0 3 0 . 6   ±   3 . 2   * S i g n i f i c a n t l y   d i f f e r e n t   ( P # 0 . 0 5 )   f r o m   t h e   c h a m b e r   c o n t r o l   g r o u p   b y   D u n n ’ s   o r   S h i r l e y ’ s   t e s t   * * P # 0 . 0 1 a M e a n   ±   s t a n d a r d   e r r o r .     S t a t i s t i c a l   t e s t s   w e r e   p e r f o r m e d   o n   u n r o u n d e d   d a t a . b n = 9 2 8 0 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   F 2 H e m a t o l o g y   a n d   C l i n i c a l   C h e m i s t r y   D a t a   f o r   R a t s   a t   t h e   3 - M o n t h   I n t e r i m   E v a l u a t i o n   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e a C h a m b e r   C o n t r o l 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 n 1 0 1 0 1 0 1 0 M a l e H e m a t o l o g y M a n u a l   h e m a t o c r i t   ( % )   4 4 . 4   ±   0 . 4 4 6 . 4   ±   0 . 4 * * 4 7 . 4   ±   0 . 4 * * 4 8 . 8   ±   0 . 3 * *   A u t o m a t e d   h e m a t o c r i t   ( % )   4 4 . 4   ±   0 . 3 4 6 . 4   ±   0 . 4 * * 4 7 . 7   ±   0 . 5 * * 4 8 . 8   ±   0 . 3 * *   H e m o g l o b i n   ( g / d L )   1 4 . 3   ±   0 . 1 1 5 . 1   ±   0 . 1 * * 1 5 . 4   ±   0 . 1 * * 1 5 . 7   ±   0 . 1 * *   E r y t h r o c y t e s   ( 1 0 6 / µ L )   7 . 9 8   ±   0 . 0 7 8 . 3 3   ±   0 . 0 8 * 8 . 4 9   ±   0 . 0 8 * * 8 . 7 1   ±   0 . 0 6 * *   R e t i c u l o c y t e s   ( 1 0 6 / µ L )   0 . 1 4   ±   0 . 0 1 0 . 1 7   ±   0 . 0 1 0 . 1 4   ±   0 . 0 1 0 . 1 5   ±   0 . 0 1   N u c l e a t e d   e r y t h r o c y t e s   ( 1 0 3 / µ L )   6 . 6 0   ±   0 . 3 4 7 . 1 0   ±   0 . 2 4 7 . 0 8   ±   0 . 2 3 6 . 4 3   ±   0 . 2 3   M e a n   c e l l   v o l u m e   ( f L ) 5 5 . 7   ±   0 . 3 5 5 . 8   ±   0 . 2 5 6 . 3   ±   0 . 2 5 6 . 2   ±   0 . 3   M e a n   c e l l   h e m o g l o b i n   ( p g ) 1 8 . 0   ±   0 . 1 1 8 . 1   ±   0 . 1 1 8 . 2   ±   0 . 1 1 8 . 1   ±   0 . 1   M e a n   c e l l   h e m o g l o b i n   c o n c e n t r a t i o n   ( g / d L )   3 2 . 3   ±   0 . 2 3 2 . 5   ±   0 . 2 3 2 . 3   ±   0 . 2 3 2 . 3   ±   0 . 2   P l a t e l e t s   ( 1 0 3 / µ L )   5 3 4 . 1   ±   1 1 . 3 5 6 0 . 7   ±   9 . 9 5 5 1 . 3   ±   1 1 . 2 5 4 9 . 8   ±   7 . 9   L e u k o c y t e s   ( 1 0 3 / µ L ) 6 . 6 0   ±   0 . 3 4 7 . 1 0   ±   0 . 2 4 7 . 0 8   ±   0 . 2 3 6 . 4 3   ±   0 . 2 3   S e g m e n t e d   n e u t r o p h i l s   ( 1 0 3 / µ L )   1 . 0 3   ±   0 . 0 5 1 . 2 8   ±   0 . 0 8 * 1 . 3 1   ±   0 . 0 7 * 1 . 2 0   ±   0 . 0 6   L y m p h o c y t e s   ( 1 0 3 / µ L ) 5 . 2 5   ±   0 . 3 2 5 . 4 5   ±   0 . 1 9 5 . 4 0   ±   0 . 2 1 4 . 8 7   ±   0 . 2 1   M o n o c y t e s   ( 1 0 3 / µ L )   0 . 2 2   ±   0 . 0 3 0 . 2 9   ±   0 . 0 3 0 . 3 5   ±   0 . 0 9 0 . 2 5   ±   0 . 0 3   B a s o p h i l s     ( 1 0 3 / µ L )   0 . 0 6 8   ±   0 . 0 1 2 0 . 0 5 0   ±   0 . 0 0 6 0 . 0 6 4   ±   0 . 0 1 2 0 . 0 7 8   ±   0 . 0 1 5   E o s i n o p h i l s   ( 1 0 3 / µ L )   0 . 0 3   ±   0 . 0 0 0 . 0 4   ±   0 . 0 0 0 . 0 4   ±   0 . 0 0 0 . 0 3   ±   0 . 0 1   C l i n i c a l   C h e m i s t r y T o t a l   i r o n   b i n d i n g   c a p a c i t y   ( µ g / d L )     5 3 9 . 2   ±   9 . 3 5 5 5 . 4   ±   5 . 8 5 5 5 . 2   ±   6 . 8 5 6 2 . 2   ±   5 . 9   U n b o u n d   i r o n   b i n d i n g   c a p a c i t y   ( µ g / d L )   4 0 7 . 0   ±   9 . 1 4 0 9 . 8   ±   8 . 6 4 0 7 . 1   ±   7 . 0 4 1 3 . 2   ±   6 . 3   I r o n   ( µ g / d L )   1 3 2 . 2   ±   2 . 6 1 4 5 . 6   ±   6 . 7 1 4 8 . 1   ±   4 . 0 * 1 4 9 . 0   ±   3 . 9 *     I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 8 1 T A B L E   F 2 H e m a t o l o g y   a n d   C l i n i c a l   C h e m i s t r y   D a t a   f o r   R a t s   a t   t h e   3 - M o n t h   I n t e r i m   E v a l u a t i o n   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r   C o n t r o l 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 n 1 0 1 0 1 0 1 0 F e m a l e H e m a t o l o g y M a n u a l   h e m a t o c r i t   ( % )   4 5 . 3   ±   0 . 3 4 6 . 3   ±   0 . 4 4 7 . 0   ±   0 . 4 * * 4 8 . 0   ±   0 . 4 * *   A u t o m a t e d   h e m a t o c r i t   ( % )   4 4 . 9   ±   0 . 4 4 6 . 3   ±   0 . 4 * 4 7 . 1   ±   0 . 5 * * 4 7 . 9   ±   0 . 2 * *   H e m o g l o b i n   ( g / d L )   1 4 . 9   ±   0 . 1 1 5 . 3   ±   0 . 1 * 1 5 . 4   ±   0 . 1 * * 1 5 . 8   ±   0 . 1 * *   E r y t h r o c y t e s   ( 1 0 6 / µ L )   7 . 7 1   ±   0 . 0 7 7 . 8 9   ±   0 . 0 6 7 . 9 7   ±   0 . 0 7 * 8 . 1 5   ±   0 . 0 2 * *   R e t i c u l o c y t e s   ( 1 0 6 / µ L )   0 . 1 4   ±   0 . 0 1 0 . 1 5   ±   0 . 0 1 0 . 1 4   ±   0 . 0 1 0 . 1 6   ±   0 . 0 1   N u c l e a t e d   e r y t h r o c y t e s   ( 1 0 3 / µ L )   7 . 0 9   ±   0 . 3 6 6 . 6 8   ±   0 . 4 3 6 . 2 2   ±   0 . 3 2 6 . 3 4   ±   0 . 3 1   M e a n   c e l l   v o l u m e   ( f L ) 5 8 . 3   ±   0 . 2 5 8 . 6   ±   0 . 2 5 9 . 2   ±   0 . 5 5 8 . 8   ±   0 . 1   M e a n   c e l l   h e m o g l o b i n   ( p g )   1 9 . 3   ±   0 . 1 1 9 . 4   ±   0 . 1 1 9 . 4   ±   0 . 1 1 9 . 4   ±   0 . 1   M e a n   c e l l   h e m o g l o b i n   c o n c e n t r a t i o n   ( g / d L )   3 3 . 1   ±   0 . 1 3 2 . 9   ±   0 . 3 3 2 . 7   ±   0 . 2 3 3 . 0   ±   0 . 2   P l a t e l e t s   ( 1 0 3 / µ L )   5 6 3 . 6   ±   6 . 7 5 6 2 . 7   ±   1 0 . 5 5 3 8 . 7   ±   8 . 1 5 6 9 . 6   ±   1 1 . 5   L e u k o c y t e s   ( 1 0 3 / µ L )   7 . 0 9   ±   0 . 3 6 6 . 6 8   ±   0 . 4 3 6 . 2 2   ±   0 . 3 2 6 . 3 4   ±   0 . 3 1   S e g m e n t e d   n e u t r o p h i l s   ( 1 0 3 / µ L )   1 . 2 0   ±   0 . 1 0 1 . 4 6   ±   0 . 1 0 1 . 4 0   ±   0 . 0 7 1 . 3 1   ±   0 . 1 0   L y m p h o c y t e s   ( 1 0 3 / µ L )   5 . 4 5   ±   0 . 2 3 4 . 8 1   ±   0 . 3 1 4 . 4 3   ±   0 . 2 7 * 4 . 6 6   ±   0 . 2 0   M o n o c y t e s   ( 1 0 3 / µ L )   0 . 3 7   ±   0 . 0 4 0 . 3 4   ±   0 . 0 5 0 . 3 2   ±   0 . 0 4 0 . 3 1   ±   0 . 0 3   B a s o p h i l s   ( 1 0 3 / µ L )   0 . 0 4 1   ±   0 . 0 0 6 0 . 0 3 9   ±   0 . 0 0 8 0 . 0 4 7   ±   0 . 0 0 4 0 . 0 3 2   ±   0 . 0 0 5   E o s i n o p h i l s   ( 1 0 3 / µ L )   0 . 0 3   ±   0 . 0 0 0 . 0 3   ±   0 . 0 0 0 . 0 2   ±   0 . 0 0 0 . 0 3   ±   0 . 0 0   C l i n i c a l   C h e m i s t r y T o t a l   i r o n   b i n d i n g   c a p a c i t y   ( µ g / d L )   5 2 3 . 2   ±   5 . 0 5 1 2 . 2   ±   5 . 7 5 3 2 . 0   ±   9 . 4 5 2 9 . 7   ±   7 . 9   U n b o u n d   i r o n   b i n d i n g   c a p a c i t y   ( µ g / d L )   3 0 8 . 5   ±   7 . 6 3 0 8 . 2   ±   1 5 . 0 3 1 5 . 1   ±   1 5 . 3 3 1 8 . 5   ±   9 . 1   I r o n   ( µ g / d L )   2 1 4 . 7   ±   7 . 3 2 0 4 . 0   ±   1 0 . 7 2 1 6 . 9   ±   1 5 . 6 2 1 1 . 2   ±   1 1 . 0   * S i g n i f i c a n t l y   d i f f e r e n t   ( P # 0 . 0 5 )   f r o m   t h e   c h a m b e r   c o n t r o l   g r o u p   b y   D u n n ’ s   o r   S h i r l e y ’ s   t e s t * * P # 0 . 0 1 a M e a n   ±   s t a n d a r d   e r r o r .     S t a t i s t i c a l   t e s t s   w e r e   p e r f o r m e d   o n   u n r o u n d e d   d a t a . 2 8 2 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   F 3   H e m a t o l o g y   D a t a   f o r   M i c e   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e a C h a m b e r   C o n t r o l 1   m g / m 3 3   m g / m 3 1 0   m g / m 3 3 0   m g / m 3 M a l e n 1 0 9 1 0 9 9 M a n u a l   h e m a t o c r i t   ( % )   4 9 . 3   ±   0 . 3 4 9 . 7   ±   0 . 5 5 1 . 1   ±   0 . 4 * * 5 2 . 8   ±   0 . 7 * * 6 0 . 8   ±   0 . 9 * *   A u t o m a t e d   h e m a t o c r i t   ( % ) 4 9 . 2   ±   0 . 3 4 9 . 1   ±   0 . 8 5 0 . 8   ±   0 . 5 * 5 2 . 3   ±   0 . 7 * * 6 1 . 0   ±   1 . 0 * *   H e m o g l o b i n   ( g / d L )   1 5 . 8   ±   0 . 1 1 5 . 5   ±   0 . 2 1 6 . 0   ±   0 . 1 1 6 . 6   ±   0 . 2 * * 1 8 . 9   ±   0 . 3 * *   E r y t h r o c y t e s   ( 1 0 6 / µ L ) 9 . 4 9   ±   0 . 1 2 9 . 9 7   ±   0 . 1 4 * 1 0 . 3 4   ±   0 . 0 9 * * 1 1 . 1 2   ±   0 . 1 3 * * 1 3 . 8 8   ±   0 . 2 1 * *   R e t i c u l o c y t e s   ( 1 0 6 / µ L ) 0 . 0 2   ±   0 . 0 0 0 . 0 3   ±   0 . 0 1 0 . 0 3   ±   0 . 0 1 0 . 0 2   ±   0 . 0 0 0 . 0 4   ±   0 . 0 1   N u c l e a t e d   e r y t h r o c y t e s /     1 0 0   l e u k o c y t e s 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0   M e a n   c e l l   v o l u m e   ( f L )   5 1 . 8   ±   0 . 5 4 9 . 3   ±   0 . 2 * * 4 9 . 2   ±   0 . 3 * * 4 7 . 0   ±   0 . 2 * * 4 3 . 9   ±   0 . 3 * *   M e a n   c e l l   h e m o g l o b i n   ( p g )   1 6 . 6   ±   0 . 2 1 5 . 6   ±   0 . 1 * * 1 5 . 5   ±   0 . 1 * * 1 4 . 9   ±   0 . 1 * * 1 3 . 6   ±   0 . 1 * *   M e a n   c e l l   h e m o g l o b i n       c o n c e n t r a t i o n   ( g / d L )   3 2 . 0   ±   0 . 1 3 1 . 6   ±   0 . 2 3 1 . 5   ±   0 . 2 * 3 1 . 8   ±   0 . 1 3 1 . 1   ±   0 . 2 * *   P l a t e l e t s   ( 1 0 3 / µ L )   7 5 1 . 0   ±   1 3 . 5 9 7 4 . 1   ±   3 5 . 1 8 6 5 . 7   ±   2 3 . 5 7 1 1 . 1   ±   3 4 . 4 6 5 6 . 8   ±   2 3 . 7   L e u k o c y t e s   ( 1 0 3 / µ L ) 3 . 7 5   ±   0 . 2 9 6 . 5 3   ±   0 . 3 0 * * 4 . 8 3   ±   0 . 4 1 4 . 1 9   ±   0 . 3 1 4 . 9 2   ±   0 . 2 9   S e g m e n t e d   n e u t r o p h i l s   ( 1 0 3 / µ L ) 2 . 7 9   ±   0 . 2 5 5 . 3 6   ±   0 . 2 8 * * 3 . 3 3   ±   0 . 3 8 2 . 9 7   ±   0 . 2 6 3 . 0 9   ±   0 . 2 7   B a n d s   ( 1 0 3 / µ L )   0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 1   ±   0 . 0 1 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0   L y m p h o c y t e s   ( 1 0 3 / µ L ) 0 . 8 7   ±   0 . 0 9 1 . 0 4   ±   0 . 1 4 1 . 3 3   ±   0 . 0 5 * * 1 . 1 0   ±   0 . 0 6 * * 1 . 7 4   ±   0 . 2 2 * *   M o n o c y t e s   ( 1 0 3 / µ L )   0 . 0 8   ±   0 . 0 3 0 . 1 2   ±   0 . 0 4 0 . 1 7   ±   0 . 0 4 0 . 1 2   ±   0 . 0 4 0 . 1 0   ±   0 . 0 2   B a s o p h i l s   0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0   E o s i n o p h i l s   ( 1 0 3 / µ L ) 0 . 0 0   ±   0 . 0 0 0 . 0 1   ±   0 . 0 1 0 . 0 0   ±   0 . 0 0 0 . 0 1   ±   0 . 0 1 0 . 0 0   ±   0 . 0 0   F e m a l e n 1 0 1 0 1 0 1 0 6 M a n u a l   h e m a t o c r i t   ( % )   5 0 . 0   ±   0 . 5 4 8 . 8   ±   0 . 4 4 9 . 4   ±   0 . 5 5 2 . 0   ±   0 . 6 6 0 . 2   ±   1 . 2 * *   A u t o m a t e d   h e m a t o c r i t   ( % ) 4 9 . 3   ±   0 . 7 4 7 . 3   ±   0 . 4 4 8 . 9   ±   0 . 4 5 1 . 0   ±   0 . 6 6 0 . 1   ±   1 . 4 * *   H e m o g l o b i n   ( g / d L )   1 5 . 8   ±   0 . 2 1 5 . 2   ±   0 . 1 1 5 . 5   ±   0 . 1 1 6 . 4   ±   0 . 2 1 8 . 6   ±   0 . 4 * *   E r y t h r o c y t e s   ( 1 0 6 / µ L ) 9 . 6 4   ±   0 . 1 4 9 . 5 8   ±   0 . 1 1 1 0 . 0 1   ±   0 . 1 1 1 0 . 7 2   ±   0 . 1 1 * * 1 3 . 4 0   ±   0 . 3 6 * *   R e t i c u l o c y t e s   ( 1 0 6 / µ L ) 0 . 0 2   ±   0 . 0 0 0 . 0 2   ±   0 . 0 1 0 . 0 2   ±   0 . 0 0 0 . 0 3   ±   0 . 0 1 0 . 0 5   ±   0 . 0 1 *   N u c l e a t e d   e r y t h r o c y t e s /     1 0 0   l e u k o c y t e s   0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0   M e a n   c e l l   v o l u m e   ( f L )   5 1 . 2   ±   0 . 1 4 9 . 2   ±   0 . 3 * * 4 8 . 8   ±   0 . 2 * * 4 7 . 6   ±   0 . 3 * * 4 5 . 0   ±   0 . 3 * *   M e a n   c e l l   h e m o g l o b i n   ( p g )   1 6 . 4   ±   0 . 1 1 5 . 9   ±   0 . 2 * * 1 5 . 5   ±   0 . 1 * * 1 5 . 3   ±   0 . 1 * * 1 3 . 9   ±   0 . 1 * *   M e a n   c e l l   h e m o g l o b i n       c o n c e n t r a t i o n   ( g / d L )   3 2 . 1   ±   0 . 2 3 2 . 1   ±   0 . 2 3 1 . 7   ±   0 . 1 * 3 2 . 2   ±   0 . 1 3 0 . 9   ±   0 . 0 * *   P l a t e l e t s   ( 1 0 3 / µ L )   7 8 2 . 7   ±   2 9 . 4 9 1 5 . 7   ±   2 4 . 9 8 3 3 . 5   ±   3 0 . 1 6 7 9 . 5   ±   1 4 . 4 * 6 1 3 . 0   ±   1 2 . 7 * *   L e u k o c y t e s   ( 1 0 3 / µ L )   2 . 4 4   ±   0 . 1 3 6 . 6 2   ±   1 . 6 3 * * 2 . 7 8   ±   0 . 1 9 2 . 8 6   ±   0 . 3 2 4 . 2 5   ±   0 . 8 3 *   S e g m e n t e d   n e u t r o p h i l s   ( 1 0 3 / µ L )   0 . 2 6   ±   0 . 0 3 2 . 6 8   ±   0 . 7 4 * * 0 . 9 0   ±   0 . 1 1 * * 0 . 7 4   ±   0 . 1 3 * * 2 . 0 8   ±   0 . 5 1 * *   B a n d s   ( 1 0 3 / µ L )   0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0   L y m p h o c y t e s   ( 1 0 3 / µ L ) 2 . 1 6   ±   0 . 1 2 3 . 7 6   ±   0 . 8 4 1 . 8 3   ±   0 . 1 3 2 . 0 6   ±   0 . 1 9 2 . 1 2   ±   0 . 3 6   M o n o c y t e s   ( 1 0 3 / µ L )   0 . 0 1   ±   0 . 0 1 0 . 1 7   ±   0 . 1 2 0 . 0 4   ±   0 . 0 1 0 . 0 5   ±   0 . 0 2 0 . 0 2   ±   0 . 0 1   B a s o p h i l s   0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0   E o s i n o p h i l s     ( 1 0 3 / µ L ) 0 . 0 1   ±   0 . 0 0 0 . 0 1   ±   0 . 0 1 0 . 0 1   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 2   ±   0 . 0 2   * S i g n i f i c a n t l y   d i f f e r e n t   ( P # 0 . 0 5 )   f r o m   t h e   c h a m b e r   c o n t r o l   g r o u p   b y   D u n n ’ s   o r   S h i r l e y ’ s   t e s t * * P # 0 . 0 1 a M e a n   ±   s t a n d a r d   e r r o r .     S t a t i s t i c a l   t e s t s   w e r e   p e r f o r m e d   o n   u n r o u n d e d   d a t a ;   n o   d a t a   w e r e   a v a i l a b l e   f o r   t h e   1 0 0   m g / m 3   g r o u p   d u e   t o   1 0 0 %   m o r t a l i t y . I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 8 3 T A B L E   F 4   H e m a t o l o g y   a n d   C l i n i c a l   C h e m i s t r y   D a t a   f o r   M i c e   a t   t h e   3 - M o n t h   I n t e r i m   E v a l u a t i o n   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e a C h a m b e r   C o n t r o l 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 M a l e H e m a t o l o g y n 1 0 1 0 1 0 1 0 M a n u a l   h e m a t o c r i t   ( % )   4 7 . 4   ±   0 . 4 4 7 . 6   ±   0 . 3 4 7 . 0   ±   0 . 4 4 6 . 6   ±   0 . 3   A u t o m a t e d   h e m a t o c r i t   ( % )   4 7 . 8   ±   0 . 5 4 7 . 6   ±   0 . 4 4 7 . 2   ±   0 . 5 4 6 . 8   ±   0 . 4   H e m o g l o b i n   ( g / d L )   1 5 . 6   ±   0 . 1 1 5 . 5   ±   0 . 1 1 5 . 2   ±   0 . 1 1 5 . 2   ±   0 . 1   E r y t h r o c y t e s   ( 1 0 6 / µ L )   9 . 6 3   ±   0 . 1 0 9 . 6 9   ±   0 . 0 8 9 . 8 3   ±   0 . 0 5 9 . 9 0   ±   0 . 0 7 *   R e t i c u l o c y t e s   ( 1 0 6 / µ L )   0 . 2 3   ±   0 . 0 1 0 . 2 3   ±   0 . 0 1 0 . 2 8   ±   0 . 0 3 0 . 3 1   ±   0 . 0 4   N u c l e a t e d   e r y t h r o c y t e s / 1 0 0   l e u k o c y t e s   0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0   M e a n   c e l l   v o l u m e   ( f L ) 4 9 . 5   ±   0 . 2 4 9 . 1   ±   0 . 3 4 8 . 1   ±   0 . 5 * * 4 7 . 1   ±   0 . 3 * *   M e a n   c e l l   h e m o g l o b i n   ( p g )   1 6 . 2   ±   0 . 1 1 6 . 0   ±   0 . 1 1 5 . 4   ±   0 . 1 * * 1 5 . 3   ±   0 . 1 * *   M e a n   c e l l   h e m o g l o b i n   c o n c e n t r a t i o n   ( g / d L )   3 2 . 6   ±   0 . 2 3 2 . 6   ±   0 . 1 3 2 . 1   ±   0 . 2 3 2 . 4   ±   0 . 1   P l a t e l e t s   ( 1 0 3 / µ L )   7 6 6 . 1   ±   1 2 . 6 8 4 6 . 9   ±   3 0 . 3 8 8 7 . 5   ±   4 9 . 4 * 1 , 0 1 9 . 1   ±   5 5 . 3 * *   L e u k o c y t e s   ( 1 0 3 / µ L )   4 . 9 5   ±   0 . 3 6 5 . 0 2   ±   0 . 4 4 5 . 2 4   ±   0 . 5 6 6 . 6 6   ±   0 . 6 2   S e g m e n t e d   n e u t r o p h i l s   ( 1 0 3 / µ L )   3 . 3 5   ±   0 . 3 1 3 . 3 4   ±   0 . 3 1 3 . 5 7   ±   0 . 6 3 4 . 6 5   ±   0 . 5 0   B a n d s   ( 1 0 3 / µ L )   0 . 0 1   ±   0 . 0 1 0 . 0 0   ±   0 . 0 0 0 . 0 1   ±   0 . 0 1 0 . 0 1   ±   0 . 0 1   L y m p h o c y t e s   ( 1 0 3 / µ L )   1 . 5 5   ±   0 . 1 3 1 . 6 4   ±   0 . 1 5 1 . 5 8   ±   0 . 2 2 1 . 9 2   ±   0 . 2 1   M o n o c y t e s   ( 1 0 3 / µ L )   0 . 0 4   ±   0 . 0 2 0 . 0 2   ±   0 . 0 1 0 . 0 6   ±   0 . 0 2 0 . 0 4   ±   0 . 0 3   B a s o p h i l s   ( 1 0 3 / µ L )   0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0   E o s i n o p h i l s   ( 1 0 3 / µ L )   0 . 0 0   ±   0 . 0 0 0 . 0 1   ±   0 . 0 1 0 . 0 2   ±   0 . 0 1 0 . 0 3   ±   0 . 0 1 * *   C l i n i c a l   C h e m i s t r y n 1 0 1 0 1 0 9 T o t a l   i r o n   b i n d i n g   c a p a c i t y   ( µ g / d L )   4 3 1 . 4   ±   5 5 . 0 4 1 7 . 4   ±   3 4 . 6 4 5 5 . 6   ±   4 4 . 1 4 6 4 . 0   ±   3 9 . 8   U n b o u n d   i r o n   b i n d i n g   c a p a c i t y   ( µ g / d L )   1 7 8 . 4   ±   7 . 4 2 1 7 . 2   ±   2 0 . 2 2 2 4 . 6   ±   3 4 . 8 2 7 1 . 3   ±   1 4 . 0 *   I r o n   ( µ g / d L )   2 5 3 . 0   ±   5 4 . 2 2 0 0 . 2   ±   3 0 . 5 2 3 1 . 0   ±   4 4 . 3 1 9 2 . 7   ±   4 8 . 7   2 8 4 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   F 4   H e m a t o l o g y   a n d   C l i n i c a l   C h e m i s t r y   D a t a   f o r   M i c e   a t   t h e   3 - M o n t h   I n t e r i m   E v a l u a t i o n   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e C h a m b e r   C o n t r o l 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 F e m a l e H e m a t o l o g y n 1 0 1 0 1 0 1 0 M a n u a l   h e m a t o c r i t   ( % )   4 8 . 8   ±   0 . 3 4 8 . 6   ±   0 . 4 4 7 . 6   ±   0 . 7 4 6 . 1   ±   0 . 5 * *   A u t o m a t e d   h e m a t o c r i t   ( % )   4 9 . 4   ±   0 . 4 4 8 . 9   ±   0 . 5 4 8 . 3   ±   0 . 8 4 6 . 0   ±   0 . 6 * *   H e m o g l o b i n   ( g / d L )   1 6 . 2   ±   0 . 1 1 6 . 0   ±   0 . 1 1 5 . 6   ±   0 . 2 * 1 5 . 0   ±   0 . 2 * *   E r y t h r o c y t e s   ( 1 0 6 / µ L )   9 . 8 1   ±   0 . 0 6 9 . 8 5   ±   0 . 0 8 1 0 . 0 5   ±   0 . 1 6 9 . 6 4   ±   0 . 0 9 R e t i c u l o c y t e s   ( 1 0 6 / µ L )   0 . 2 1   ±   0 . 0 1 0 . 2 5   ±   0 . 0 2 0 . 2 4   ±   0 . 0 3 0 . 3 0   ±   0 . 0 4   N u c l e a t e d   e r y t h r o c y t e s / 1 0 0   l e u k o c y t e s   0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0   M e a n   c e l l   v o l u m e   ( f L ) 5 0 . 4   ±   0 . 2 4 9 . 5   ±   0 . 3 * 4 8 . 0   ±   0 . 4 * * 4 7 . 6   ±   0 . 4 * *   M e a n   c e l l   h e m o g l o b i n   ( p g ) 1 6 . 5   ±   0 . 1 1 6 . 2   ±   0 . 1 * 1 5 . 6   ±   0 . 1 * * 1 5 . 6   ±   0 . 2 * *   M e a n   c e l l   h e m o g l o b i n   c o n c e n t r a t i o n   ( g / d L )   3 2 . 8   ±   0 . 1 3 2 . 6   ±   0 . 1 3 2 . 4   ±   0 . 2 3 2 . 7   ±   0 . 1   P l a t e l e t s   ( 1 0 3 / µ L )   7 3 0 . 4   ±   1 2 . 2 7 7 7 . 8   ±   4 3 . 2 9 0 3 . 4   ±   5 3 . 2 * * 9 4 5 . 0   ±   4 6 . 8 * *   L e u k o c y t e s   ( 1 0 3 / µ L )   2 . 5 0   ±   0 . 1 4 3 . 2 3   ±   0 . 2 4 * 4 . 7 3   ±   0 . 5 7 * * 6 . 5 8   ±   1 . 0 0 * *   S e g m e n t e d   n e u t r o p h i l s   ( 1 0 3 / µ L )   0 . 2 8   ±   0 . 0 5 0 . 6 3   ±   0 . 1 4 * 1 . 9 7   ±   0 . 5 3 * * 3 . 0 0   ±   0 . 7 9 * *   B a n d s   ( 1 0 3 / µ L )   0 . 0 0   ±   0 . 0 0 0 . 0 0   ±   0 . 0 0 0 . 0 2   ±   0 . 0 2 0 . 0 1   ±   0 . 0 1   L y m p h o c y t e s   ( 1 0 3 / µ L )   2 . 2 0   ±   0 . 1 4 2 . 5 2   ±   0 . 1 4 2 . 6 4   ±   0 . 1 9 3 . 3 8   ±   0 . 3 2 * *   M o n o c y t e s   ( 1 0 3 / µ L )   0 . 0 2   ±   0 . 0 1 0 . 0 7   ±   0 . 0 3 0 . 1 1   ±   0 . 0 5 0 . 1 8   ±   0 . 0 6 *   B a s o p h i l s   ( 1 0 3 / µ L )   0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0 0 . 0 0 0   ±   0 . 0 0 0   E o s i n o p h i l s   ( 1 0 3 / µ L )   0 . 0 0   ±   0 . 0 0 0 . 0 1   ±   0 . 0 0 0 . 0 1   ±   0 . 0 1 0 . 0 2   ±   0 . 0 1   C l i n i c a l   C h e m i s t r y n 1 0 1 0 1 0 1 0 T o t a l   i r o n   b i n d i n g   c a p a c i t y   ( µ g / d L )   4 2 0 . 4   ±   5 . 2 4 3 6 . 8   ±   6 . 6 4 8 0 . 6   ±   1 3 . 2 * * 5 6 4 . 6   ±   4 4 . 6 * *   U n b o u n d   i r o n   b i n d i n g   c a p a c i t y   ( µ g / d L )   2 1 0 . 0   ±   7 . 6 2 7 7 . 7   ±   1 9 . 2 * * 2 7 9 . 2   ±   2 5 . 5 * 3 6 0 . 8   ±   3 0 . 5 * *   I r o n   ( µ g / d L )   2 1 0 . 4   ±   8 . 5 1 5 9 . 1   ±   1 3 . 2 2 0 1 . 4   ±   2 4 . 7 2 0 3 . 8   ±   6 4 . 7   * S i g n i f i c a n t l y   d i f f e r e n t   ( P # 0 . 0 5 )   f r o m   t h e   c h a m b e r   c o n t r o l   g r o u p   b y   D u n n ’ s   o r   S h i r l e y ’ s   t e s t * * P # 0 . 0 1 a M e a n   ±   s t a n d a r d   e r r o r .     S t a t i s t i c a l   t e s t s   w e r e   p e r f o r m e d   o n   u n r o u n d e d   d a t a . 2 8 5 A P P E N D I X   G O R G A N   W E I G H T S A N D   O R G A N - W E I G H T - T O - B O D Y - W E I G H T   R A T I O S T A B L E   G 1 O r g a n   W e i g h t s   a n d   O r g a n - W e i g h t - t o - B o d y - W e i g h t   R a t i o s   f o r   R a t s i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 8 6 T A B L E   G 2 O r g a n   W e i g h t s   a n d   O r g a n - W e i g h t - t o - B o d y - W e i g h t   R a t i o s   f o r   R a t s a t   t h e   3 - M o n t h   I n t e r i m   E v a l u a t i o n   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 8 7 T A B L E   G 3 O r g a n   W e i g h t s   a n d   O r g a n - W e i g h t - t o - B o d y - W e i g h t   R a t i o s   f o r   M i c e i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 8 8 T A B L E   G 4 O r g a n   W e i g h t s   a n d   O r g a n - W e i g h t - t o - B o d y - W e i g h t   R a t i o s   f o r   M i c e a t   t h e   3 - M o n t h   I n t e r i m   E v a l u a t i o n   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 8 9 2 8 6 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   G 1 O r g a n   W e i g h t s   a n d   O r g a n - W e i g h t - t o - B o d y - W e i g h t   R a t i o s   f o r   R a t s   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e a C h a m b e r C o n t r o l 1   m g / m 3 3   m g / m 3 1 0   m g / m 3 3 0   m g / m 3 1 0 0   m g / m 3 M a l e n 1 0 1 0 1 0 1 0 1 0 9 N e c r o p s y   b o d y   w t 3 6 5   ±   6 3 4 1   ±   7 * * 3 2 2   ±   5 * * 3 3 1   ±   4 * * 3 2 5   ±   9 * * 1 7 2   ±   6 * *   H e a r t A b s o l u t e 1 . 0 2 5   ±   0 . 0 1 7 0 . 9 7 7   ±   0 . 0 1 7 0 . 9 6 0   ±   0 . 0 2 2 0 . 9 7 4   ±   0 . 0 1 5 0 . 9 9 9   ±   0 . 0 2 1 1 . 0 0 3   ±   0 . 0 2 6   R e l a t i v e 0 . 2 8 1   ±   0 . 0 0 4 0 . 2 8 7   ±   0 . 0 0 4 0 . 2 9 8   ±   0 . 0 0 5 0 . 2 9 4   ±   0 . 0 0 3 0 . 3 0 8   ±   0 . 0 0 6 * 0 . 5 8 7   ±   0 . 0 1 8 * *   R .   K i d n e y A b s o l u t e 1 . 1 4 7   ±   0 . 0 1 8 1 . 0 9 3   ±   0 . 0 2 5 1 . 0 4 2   ±   0 . 0 2 1 * 1 . 0 6 8   ±   0 . 0 1 6 * 1 . 0 5 3   ±   0 . 0 2 7 * * 0 . 9 5 7   ±   0 . 0 3 6 * *   R e l a t i v e 0 . 3 1 5   ±   0 . 0 0 6 0 . 3 2 1   ±   0 . 0 0 5 0 . 3 2 3   ±   0 . 0 0 5 0 . 3 2 3   ±   0 . 0 0 4 0 . 3 2 4   ±   0 . 0 0 5 0 . 5 6 1   ±   0 . 0 2 8 * *   L i v e r A b s o l u t e 1 1 . 8 9 7   ±   0 . 2 1 1 1 1 . 1 3 5   ±   0 . 3 2 6 1 0 . 5 0 4   ±   0 . 3 6 4 * 1 1 . 2 1 9   ±   0 . 2 9 7 * 1 0 . 6 4 2   ±   0 . 2 9 8 * * 6 . 8 4 3   ±   0 . 2 5 8 * *   R e l a t i v e 3 . 2 6 7   ±   0 . 0 5 6 3 . 2 6 7   ±   0 . 0 5 6 3 . 2 5 6   ±   0 . 0 9 1 3 . 3 9 0   ±   0 . 0 9 2 3 . 2 7 4   ±   0 . 0 4 2 3 . 9 9 2   ±   0 . 1 3 1 * *   L u n g A b s o l u t e 1 . 9 6 9   ±   0 . 1 3 0 5 . 3 2 6   ±   0 . 1 4 5 * * 6 . 4 5 1   ±   0 . 1 6 9 * * 6 . 3 4 1   ±   0 . 1 1 3 * * 7 . 1 5 9   ±   0 . 1 9 0 * * 5 . 0 8 0   ±   0 . 1 6 2 * *   R e l a t i v e 0 . 5 4 0   ±   0 . 0 3 4 1 . 5 6 3   ±   0 . 0 2 3 * * 2 . 0 0 1   ±   0 . 0 4 5 * * 1 . 9 1 4   ±   0 . 0 2 3 * * 2 . 2 0 5   ±   0 . 0 4 1 * * 2 . 9 5 7   ±   0 . 0 3 9 * *   R .   T e s t i s A b s o l u t e 1 . 4 3 4   ±   0 . 0 2 3 1 . 4 4 1   ±   0 . 0 2 3 1 . 4 3 0   ±   0 . 0 3 1 1 . 4 2 9   ±   0 . 0 1 0 1 . 4 3 6   ±   0 . 0 2 9 0 . 7 6 2   ±   0 . 0 7 0 * *   R e l a t i v e 0 . 3 9 4   ±   0 . 0 0 7 0 . 4 2 4   ±   0 . 0 0 4 0 . 4 4 4   ±   0 . 0 0 8 * 0 . 4 3 2   ±   0 . 0 0 5 * 0 . 4 4 3   ±   0 . 0 0 8 * 0 . 4 3 7   ±   0 . 0 2 8 *   T h y m u s A b s o l u t e 0 . 3 1 9   ±   0 . 0 1 7 0 . 2 8 1   ±   0 . 0 1 7 0 . 3 2 1   ±   0 . 0 2 1 0 . 3 3 0   ±   0 . 0 1 6 0 . 3 0 1   ±   0 . 0 1 7 0 . 1 4 6   ±   0 . 0 1 6 * * R e l a t i v e 0 . 0 8 7   ±   0 . 0 0 4 0 . 0 8 3   ±   0 . 0 0 5 0 . 1 0 0   ±   0 . 0 0 7 0 . 0 9 9   ±   0 . 0 0 5 0 . 0 9 3   ±   0 . 0 0 5 0 . 0 8 4   ±   0 . 0 0 7 F e m a l e n 1 0 1 0 1 0 1 0 1 0 1 0 N e c r o p s y   b o d y   w t 2 0 6   ±   3 2 0 5   ±   3 1 9 9   ±   4 2 0 6   ±   3 1 9 6   ±   5 1 1 7   ±   3 * *   H e a r t A b s o l u t e 0 . 6 5 8   ±   0 . 0 1 1 0 . 6 5 5   ±   0 . 0 1 0 0 . 6 6 2   ±   0 . 0 1 0 0 . 7 2 2   ±   0 . 0 1 2 * * 0 . 7 1 8   ±   0 . 0 2 1 * * 0 . 7 8 8   ±   0 . 0 1 7 * *   R e l a t i v e 0 . 3 1 9   ±   0 . 0 0 3 0 . 3 1 9   ±   0 . 0 0 3 0 . 3 3 4   ±   0 . 0 0 7 0 . 3 5 1   ±   0 . 0 0 7 0 . 3 6 7   ±   0 . 0 0 8 * * 0 . 6 7 9   ±   0 . 0 2 6 * *   R .   K i d n e y A b s o l u t e 0 . 6 8 4   ±   0 . 0 1 4 0 . 6 6 1   ±   0 . 0 1 0 0 . 6 7 2   ±   0 . 0 1 1 0 . 6 8 9   ±   0 . 0 0 9 0 . 6 6 4   ±   0 . 0 2 1 0 . 6 1 7   ±   0 . 0 1 9 * *   R e l a t i v e 0 . 3 3 2   ±   0 . 0 0 6 0 . 3 2 3   ±   0 . 0 0 5 0 . 3 3 8   ±   0 . 0 0 6 0 . 3 3 4   ±   0 . 0 0 3 0 . 3 3 9   ±   0 . 0 0 6 0 . 5 3 0   ±   0 . 0 1 8 * *   L i v e r A b s o l u t e 6 . 3 4 1   ±   0 . 1 4 6 6 . 1 6 8   ±   0 . 1 2 6 6 . 2 1 2   ±   0 . 2 5 4 6 . 6 4 2   ±   0 . 1 7 9 6 . 3 8 0   ±   0 . 2 3 1 4 . 3 7 2   ±   0 . 1 3 3 * *   R e l a t i v e 3 . 0 7 4   ±   0 . 0 5 9 3 . 0 0 5   ±   0 . 0 3 1 3 . 1 1 3   ±   0 . 0 7 4 3 . 2 1 9   ±   0 . 0 6 2 3 . 2 5 2   ±   0 . 0 6 0 3 . 7 4 2   ±   0 . 0 7 1 * *   L u n g A b s o l u t e 1 . 2 2 0   ±   0 . 0 5 1 3 . 4 4 1   ±   0 . 1 0 4 * * 3 . 8 7 6   ±   0 . 0 8 9 * * 4 . 6 2 1   ±   0 . 0 9 9 * * 5 . 3 0 3   ±   0 . 2 0 0 * * 3 . 8 9 9   ±   0 . 1 2 3 * *   R e l a t i v e 0 . 5 9 0   ±   0 . 0 1 9 1 . 6 7 8   ±   0 . 0 4 7 * * 1 . 9 5 3   ±   0 . 0 5 2 * * 2 . 2 4 6   ±   0 . 0 6 3 * * 2 . 7 0 9   ±   0 . 0 8 0 * * 3 . 3 3 4   ±   0 . 0 6 3 * *   T h y m u s A b s o l u t e 0 . 2 4 1   ±   0 . 0 1 2 0 . 2 3 3   ±   0 . 0 1 6 0 . 2 4 8   ±   0 . 0 1 6 0 . 2 4 4   ±   0 . 0 1 5 0 . 2 4 2   ±   0 . 0 0 8 0 . 0 9 7   ±   0 . 0 0 9 * *   R e l a t i v e 0 . 1 1 7   ±   0 . 0 0 5 0 . 1 1 3   ±   0 . 0 0 7 0 . 1 2 5   ±   0 . 0 0 7 0 . 1 1 7   ±   0 . 0 0 6 0 . 1 2 4   ±   0 . 0 0 6 0 . 0 8 2   ±   0 . 0 0 7 * *   * S i g n i f i c a n t l y   d i f f e r e n t   ( P # 0 . 0 5 )   f r o m   t h e   c h a m b e r   c o n t r o l   g r o u p   b y   W i l l i a m s ’   o r   D u n n e t t ’ s   t e s t * * P # 0 . 0 1 a O r g a n   w e i g h t s   ( a b s o l u t e   w e i g h t s )   a n d   b o d y   w e i g h t s   a r e   g i v e n   i n   g r a m s ;   o r g a n - w e i g h t - t o - b o d y - w e i g h t   r a t i o s   ( r e l a t i v e   w e i g h t s )   a r e   g i v e n   a s g   o r g a n   w e i g h t / g   b o d y   w e i g h t   a s   a   p e r c e n t a g e   ( m e a n   ±   s t a n d a r d   e r r o r ) . I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 8 7 T A B L E   G 2 O r g a n   W e i g h t s   a n d   O r g a n - W e i g h t - t o - B o d y - W e i g h t   R a t i o s   f o r   R a t s   a t   t h e   3 - M o n t h   I n t e r i m   E v a l u a t i o n   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e a C h a m b e r   C o n t r o l 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 n 1 0 1 0 1 0 1 0 M a l e N e c r o p s y   b o d y   w t 3 2 6   ±   8 3 3 2   ±   5 3 2 8   ±   7 3 2 3   ±   6   H e a r t A b s o l u t e 1 . 0 8 9   ±   0 . 1 8 1 0 . 9 4 3   ±   0 . 0 1 7 1 . 0 7 4   ±   0 . 1 7 7 0 . 9 0 8   ±   0 . 0 1 8   R e l a t i v e 0 . 3 3 6   ±   0 . 0 5 7 0 . 2 8 4   ±   0 . 0 0 3 0 . 3 2 7   ±   0 . 0 5 2 0 . 2 8 1   ±   0 . 0 0 3   R .   K i d n e y A b s o l u t e 1 . 0 7 5   ±   0 . 1 7 8 0 . 9 3 4   ±   0 . 0 2 3 1 . 0 8 8   ±   0 . 1 7 9 0 . 9 1 8   ±   0 . 0 2 6   R e l a t i v e 0 . 3 3 1   ±   0 . 0 5 6 0 . 2 8 1   ±   0 . 0 0 4 0 . 3 3 1   ±   0 . 0 5 3 0 . 2 8 4   ±   0 . 0 0 5   L i v e r A b s o l u t e 1 0 . 4 5 3   ±   0 . 3 8 1 1 0 . 5 3 7   ±   0 . 2 0 5 1 0 . 3 5 9   ±   0 . 2 9 2 1 0 . 5 7 6   ±   0 . 3 4 9   R e l a t i v e 3 . 2 0 5   ±   0 . 0 6 6 3 . 1 7 4   ±   0 . 0 5 0 3 . 1 5 4   ±   0 . 0 5 7 3 . 2 7 6   ±   0 . 0 8 3   L u n g A b s o l u t e 1 . 8 2 5   ±   0 . 2 0 3 2 . 2 2 7   ±   0 . 0 5 8 2 . 8 3 5   ±   0 . 1 9 1 * * 3 . 8 4 3   ±   0 . 0 9 8 * *   R e l a t i v e 0 . 5 5 8   ±   0 . 0 6 1 0 . 6 7 0   ±   0 . 0 1 4 0 . 8 6 3   ±   0 . 0 5 4 * * 1 . 1 9 0   ±   0 . 0 1 9 * *   R .   T e s t i s A b s o l u t e 1 . 5 1 4   ±   0 . 1 8 2 1 . 3 6 2   ±   0 . 0 2 4 1 . 5 5 0   ±   0 . 1 8 5 1 . 3 5 1   ±   0 . 0 1 9   R e l a t i v e 0 . 4 6 7   ±   0 . 0 5 8 0 . 4 1 0   ±   0 . 0 0 6 0 . 4 7 2   ±   0 . 0 5 5 0 . 4 1 9   ±   0 . 0 0 6   T h y m u s A b s o l u t e 0 . 4 8 9   ±   0 . 1 8 0 0 . 3 1 3   ±   0 . 0 1 3 0 . 5 0 5   ±   0 . 1 7 3 0 . 3 2 8   ±   0 . 0 1 4   R e l a t i v e 0 . 1 5 2   ±   0 . 0 5 7 0 . 0 9 4   ±   0 . 0 0 3 0 . 1 5 3   ±   0 . 0 5 2 0 . 1 0 1   ±   0 . 0 0 3   F e m a l e N e c r o p s y   b o d y   w t 1 8 9   ±   4 1 8 4   ±   5 1 9 1   ±   3 1 7 9   ±   5   H e a r t A b s o l u t e 0 . 5 9 5   ±   0 . 0 1 0 0 . 5 8 4   ±   0 . 0 1 6 0 . 5 9 5   ±   0 . 0 1 2 0 . 5 9 7   ±   0 . 0 2 1   R e l a t i v e 0 . 3 1 5   ±   0 . 0 0 5 0 . 3 1 7   ±   0 . 0 0 5 0 . 3 1 2   ±   0 . 0 0 3 0 . 3 3 4   ±   0 . 0 0 6 *   R .   K i d n e y A b s o l u t e 0 . 5 6 8   ±   0 . 0 1 3 0 . 5 5 3   ±   0 . 0 1 4 0 . 5 7 4   ±   0 . 0 1 1 0 . 5 4 6   ±   0 . 0 1 7   R e l a t i v e 0 . 3 0 1   ±   0 . 0 0 4 0 . 3 0 0   ±   0 . 0 0 3 0 . 3 0 1   ±   0 . 0 0 3 0 . 3 0 6   ±   0 . 0 0 5   L i v e r A b s o l u t e 5 . 5 2 5   ±   0 . 1 3 1 5 . 1 3 6   ±   0 . 1 6 2 5 . 1 9 7   ±   0 . 1 8 2 5 . 0 0 4   ±   0 . 1 7 3   R e l a t i v e 2 . 9 2 6   ±   0 . 0 4 6 2 . 7 8 8   ±   0 . 0 4 6 2 . 7 2 2   ±   0 . 0 5 7 * * 2 . 7 9 8   ±   0 . 0 2 5   L u n g A b s o l u t e 1 . 1 0 7   ±   0 . 0 3 6 1 . 3 5 2   ±   0 . 0 3 7 * * 1 . 7 0 3   ±   0 . 0 5 2 * * 2 . 3 3 4   ±   0 . 0 8 9 * *   R e l a t i v e 0 . 5 8 8   ±   0 . 0 2 1 0 . 7 3 5   ±   0 . 0 1 3 * * 0 . 8 9 6   ±   0 . 0 3 0 * * 1 . 3 0 8   ±   0 . 0 3 6   * * T h y m u s A b s o l u t e 0 . 2 3 5   ±   0 . 0 1 3 0 . 2 3 5   ±   0 . 0 1 1 0 . 2 5 4   ±   0 . 0 1 2 0 . 2 5 9   ±   0 . 0 0 8   R e l a t i v e 0 . 1 2 5   ±   0 . 0 0 7 0 . 1 2 7   ±   0 . 0 0 4 0 . 1 3 3   ±   0 . 0 0 4 0 . 1 4 5   ±   0 . 0 0 5 * *   * S i g n i f i c a n t l y   d i f f e r e n t   ( P # 0 . 0 5 )   f r o m   t h e   c h a m b e r   c o n t r o l   g r o u p   b y   W i l l i a m s ’   o r   D u n n e t t ’ s   t e s t * * P # 0 . 0 1 a O r g a n   w e i g h t s   ( a b s o l u t e   w e i g h t s )   a n d   b o d y   w e i g h t s   a r e   g i v e n   i n   g r a m s ;   o r g a n - w e i g h t - t o - b o d y - w e i g h t   r a t i o s   ( r e l a t i v e   w e i g h t s )   a r e   g i v e n   a s g   o r g a n   w e i g h t / g   b o d y   w e i g h t   a s   a   p e r c e n t a g e   ( m e a n   ±   s t a n d a r d   e r r o r ) . 2 8 8 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 T A B L E   G 3 O r g a n   W e i g h t s   a n d   O r g a n - W e i g h t - t o - B o d y - W e i g h t   R a t i o s   f o r   M i c e   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e a C h a m b e r   C o n t r o l 1   m g / m 3 3   m g / m 3 1 0   m g / m 3 3 0   m g / m 3 M a l e n 1 0 1 0 1 0 1 0 9 N e c r o p s y   b o d y   w t 3 7 . 8   ±   0 . 6 3 7 . 4   ±   0 . 6 3 5 . 6   ±   0 . 6 * 3 2 . 8   ±   0 . 5 * * 2 4 . 3   ±   0 . 8 * *   H e a r t A b s o l u t e 0 . 1 6 4   ±   0 . 0 0 4 0 . 1 7 0   ±   0 . 0 0 6 0 . 1 6 7   ±   0 . 0 0 6 0 . 1 6 8   ±   0 . 0 0 6 0 . 1 4 1   ±   0 . 0 0 5 *   R e l a t i v e 0 . 4 3 5   ±   0 . 0 1 3 0 . 4 5 7   ±   0 . 0 2 2 0 . 4 6 9   ±   0 . 0 1 4 0 . 5 1 3   ±   0 . 0 2 2 * * 0 . 5 8 2   ±   0 . 0 2 0 * *   R .   K i d n e y A b s o l u t e 0 . 3 0 9   ±   0 . 0 1 0 0 . 3 0 0   ±   0 . 0 0 8 0 . 2 9 8   ±   0 . 0 0 7 0 . 2 9 7   ±   0 . 0 0 7 0 . 2 3 7   ±   0 . 0 1 0 * *   R e l a t i v e 0 . 8 1 6   ±   0 . 0 1 7 0 . 8 0 3   ±   0 . 0 2 2 0 . 8 3 8   ±   0 . 0 1 7 0 . 9 0 6   ±   0 . 0 1 8 * * 0 . 9 7 0   ±   0 . 0 1 8 * *   L i v e r A b s o l u t e 1 . 6 0 3   ±   0 . 0 4 6 1 . 5 4 1   ±   0 . 0 4 9 1 . 4 8 0   ±   0 . 0 4 0 1 . 4 8 5   ±   0 . 0 6 4 1 . 1 6 3   ±   0 . 0 4 0 * *   R e l a t i v e 4 . 2 4 8   ±   0 . 1 4 1 4 . 1 3 2   ±   0 . 1 6 2 4 . 1 6 6   ±   0 . 1 2 2 4 . 5 4 4   ±   0 . 2 3 1 4 . 7 7 9   ±   0 . 0 7 6 *   L u n g A b s o l u t e 0 . 2 1 9   ±   0 . 0 0 6 0 . 5 6 4   ±   0 . 0 1 0 * * 0 . 6 1 3   ±   0 . 0 1 4 * * 0 . 8 6 9   ±   0 . 0 1 6 * * 0 . 8 8 7   ±   0 . 0 3 5 * *   R e l a t i v e 0 . 5 8 1   ±   0 . 0 2 0 1 . 5 1 1   ±   0 . 0 3 3 * * 1 . 7 2 5   ±   0 . 0 4 0 * * 2 . 6 5 6   ±   0 . 0 7 1 * * 3 . 6 5 3   ±   0 . 1 3 4 * *   R .   T e s t i s A b s o l u t e 0 . 1 1 7   ±   0 . 0 0 2 0 . 1 2 0   ±   0 . 0 0 2 0 . 1 0 8   ±   0 . 0 0 3 0 . 1 1 3   ±   0 . 0 0 2 0 . 1 0 3   ±   0 . 0 0 3 * *   R e l a t i v e 0 . 3 1 1   ±   0 . 0 0 5 0 . 3 2 2   ±   0 . 0 0 7 0 . 3 0 5   ±   0 . 0 1 2 0 . 3 4 5   ±   0 . 0 0 9 * 0 . 4 2 4   ±   0 . 0 1 5 * *   T h y m u s A b s o l u t e 0 . 0 3 9   ±   0 . 0 0 3 0 . 0 3 9   ±   0 . 0 0 3 0 . 0 3 4   ±   0 . 0 0 1 0 . 0 3 8   ±   0 . 0 0 3 0 . 0 1 7   ±   0 . 0 0 2 * *   R e l a t i v e 0 . 1 0 4   ±   0 . 0 0 7 0 . 1 0 4   ±   0 . 0 0 8 0 . 0 9 5   ±   0 . 0 0 4 0 . 1 1 5   ±   0 . 0 1 1 0 . 0 6 8   ±   0 . 0 0 7 * *   F e m a l e n 1 0 1 0 1 0 1 0 6 N e c r o p s y   b o d y   w t 3 2 . 5   ±   0 . 6 3 2 . 5   ±   0 . 5 3 1 . 1   ±   0 . 9 2 8 . 4   ±   0 . 4 * * 2 2 . 2   ±   0 . 3 * *   H e a r t A b s o l u t e 0 . 1 3 3   ±   0 . 0 0 3 0 . 1 4 3   ±   0 . 0 0 3 0 . 1 4 3   ±   0 . 0 0 3 0 . 1 4 2   ±   0 . 0 0 3 0 . 1 3 7   ±   0 . 0 0 5   R e l a t i v e 0 . 4 1 0   ±   0 . 0 0 7 0 . 4 4 0   ±   0 . 0 0 7 0 . 4 6 2   ±   0 . 0 1 5 * * 0 . 5 0 1   ±   0 . 0 1 2 * * 0 . 6 1 0   ±   0 . 0 1 6 * *   R .   K i d n e y A b s o l u t e 0 . 2 1 7   ±   0 . 0 0 7 0 . 2 2 3   ±   0 . 0 0 4 0 . 2 1 2   ±   0 . 0 0 3 0 . 2 1 9   ±   0 . 0 0 6 0 . 1 8 8   ±   0 . 0 0 4 * *   R e l a t i v e 0 . 6 6 9   ±   0 . 0 2 3 0 . 6 8 7   ±   0 . 0 1 5 0 . 6 8 6   ±   0 . 0 2 2 0 . 7 7 3   ±   0 . 0 2 3 * * 0 . 8 5 0   ±   0 . 0 1 2 * *   L i v e r A b s o l u t e 1 . 5 7 4   ±   0 . 0 3 1 1 . 5 9 5   ±   0 . 0 2 3 1 . 5 6 4   ±   0 . 0 3 6 1 . 4 9 9   ±   0 . 0 3 3 1 . 3 2 2   ±   0 . 0 2 8 * *   R e l a t i v e 4 . 8 5 0   ±   0 . 0 9 6 4 . 9 0 6   ±   0 . 0 5 2 5 . 0 3 5   ±   0 . 0 6 9 5 . 2 8 1   ±   0 . 0 8 8 * * 5 . 9 7 1   ±   0 . 1 3 4 * *   L u n g A b s o l u t e 0 . 2 2 5   ±   0 . 0 0 8 0 . 5 8 2   ±   0 . 0 1 0 * * 0 . 6 8 4   ±   0 . 0 1 1 * * 0 . 8 6 1   ±   0 . 0 2 0 * * 0 . 8 0 8   ±   0 . 0 2 1 * *   R e l a t i v e 0 . 6 9 4   ±   0 . 0 2 6 1 . 7 9 1   ±   0 . 0 2 9 * * 2 . 2 1 1   ±   0 . 0 6 4 * * 3 . 0 4 2   ±   0 . 0 9 3 * * 3 . 6 5 0   ±   0 . 0 8 5 * *   T h y m u s A b s o l u t e 0 . 0 4 7   ±   0 . 0 0 4 0 . 0 5 1   ±   0 . 0 0 3 0 . 0 4 8   ±   0 . 0 0 3 0 . 0 4 6   ±   0 . 0 0 3 0 . 0 2 4   ±   0 . 0 0 4 * *   R e l a t i v e 0 . 1 4 4   ±   0 . 0 1 2 0 . 1 5 6   ±   0 . 0 0 9 0 . 1 5 5   ±   0 . 0 0 8 0 . 1 6 1   ±   0 . 0 0 9 0 . 1 0 9   ±   0 . 0 1 9   * S i g n i f i c a n t l y   d i f f e r e n t   ( P # 0 . 0 5 )   f r o m   t h e   c h a m b e r   c o n t r o l   g r o u p   b y   W i l l i a m s ’   o r   D u n n e t t ’ s   t e s t * * P # 0 . 0 1 a O r g a n   w e i g h t s   ( a b s o l u t e   w e i g h t s )   a n d   b o d y   w e i g h t s   a r e   g i v e n   i n   g r a m s ;   o r g a n - w e i g h t - t o - b o d y - w e i g h t   r a t i o s   ( r e l a t i v e   w e i g h t s )   a r e   g i v e n   a s g   o r g a n   w e i g h t / g   b o d y   w e i g h t   a s   a   p e r c e n t a g e   ( m e a n   ±   s t a n d a r d   e r r o r ) .     N o   d a t a   w e r e   a v a i l a b l e   f o r   t h e   1 0 0   m g / m 3   g r o u p   d u e   t o   1 0 0 % m o r t a l i t y . I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 8 9 T A B L E   G 4 O r g a n   W e i g h t s   a n d   O r g a n - W e i g h t - t o - B o d y - W e i g h t   R a t i o s   f o r   M i c e   a t   t h e   3 - M o n t h   I n t e r i m   E v a l u a t i o n   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e a C h a m b e r   C o n t r o l 0 . 0 3   m g / m 3 0 . 1   m g / m 3 0 . 3   m g / m 3 n 1 0 1 0 1 0 1 0 M a l e N e c r o p s y   b o d y   w t 3 5 . 4   ±   0 . 8 3 5 . 9   ±   1 . 1 3 3 . 3   ±   0 . 6 3 3 . 8   ±   0 . 7   H e a r t A b s o l u t e 0 . 1 4 8   ±   0 . 0 0 2 0 . 1 5 1   ±   0 . 0 0 4 0 . 1 4 7   ±   0 . 0 0 4 0 . 1 4 7   ±   0 . 0 0 3   R e l a t i v e 0 . 4 2 0   ±   0 . 0 1 0 0 . 4 2 3   ±   0 . 0 1 1 0 . 4 4 1   ±   0 . 0 0 6 0 . 4 3 6   ±   0 . 0 0 9   R .   K i d n e y A b s o l u t e 0 . 3 0 0   ±   0 . 0 1 1 0 . 2 9 7   ±   0 . 0 0 9 0 . 2 7 7   ±   0 . 0 0 7 0 . 2 8 0   ±   0 . 0 0 9   R e l a t i v e 0 . 8 4 8   ±   0 . 0 2 2 0 . 8 3 2   ±   0 . 0 2 5 0 . 8 3 3   ±   0 . 0 1 5 0 . 8 3 0   ±   0 . 0 2 5   L i v e r A b s o l u t e 1 . 4 3 8   ±   0 . 0 3 2 1 . 4 2 7   ±   0 . 0 4 1 1 . 3 5 7   ±   0 . 0 4 4 1 . 3 4 0   ±   0 . 0 2 6   R e l a t i v e 4 . 0 7 3   ±   0 . 0 8 4 3 . 9 8 9   ±   0 . 0 7 0 4 . 0 7 3   ±   0 . 0 8 5 3 . 9 7 4   ±   0 . 0 8 1   L u n g A b s o l u t e 0 . 2 1 3   ±   0 . 0 0 3 0 . 3 0 0   ±   0 . 0 0 7 * * 0 . 3 6 6   ±   0 . 0 1 9 * * 0 . 4 5 1   ±   0 . 0 0 8 * *   R e l a t i v e 0 . 6 0 3   ±   0 . 0 0 8 0 . 8 4 9   ±   0 . 0 4 6 * * 1 . 1 0 3   ±   0 . 0 6 2 * * 1 . 3 4 0   ±   0 . 0 3 5 * *   R .   T e s t i s A b s o l u t e 0 . 1 0 9   ±   0 . 0 0 5 0 . 1 1 4   ±   0 . 0 0 2 0 . 1 0 9   ±   0 . 0 0 2 0 . 1 1 1   ±   0 . 0 0 2   R e l a t i v e 0 . 3 1 0   ±   0 . 0 1 3 0 . 3 2 1   ±   0 . 0 1 0 0 . 3 2 9   ±   0 . 0 0 8 0 . 3 3 0   ±   0 . 0 0 6   T h y m u s A b s o l u t e 0 . 0 3 5   ±   0 . 0 0 2 0 . 0 3 5   ±   0 . 0 0 2 0 . 0 3 7   ±   0 . 0 0 2 0 . 0 3 9   ±   0 . 0 0 2   R e l a t i v e 0 . 1 0 0   ±   0 . 0 0 4 0 . 0 9 7   ±   0 . 0 0 5 0 . 1 1 0   ±   0 . 0 0 6 0 . 1 1 5   ±   0 . 0 0 8   F e m a l e N e c r o p s y   b o d y   w t 3 0 . 5   ±   0 . 8 3 0 . 5   ±   1 . 3 2 8 . 8   ±   0 . 6 2 8 . 3   ±   0 . 6   H e a r t A b s o l u t e 0 . 1 2 8   ±   0 . 0 0 2 0 . 1 2 9   ±   0 . 0 0 3 0 . 1 3 2   ±   0 . 0 0 2 0 . 1 2 9   ±   0 . 0 0 3   R e l a t i v e 0 . 4 2 3   ±   0 . 0 1 4 0 . 4 2 8   ±   0 . 0 1 6 0 . 4 5 9   ±   0 . 0 1 0 0 . 4 5 7   ±   0 . 0 1 0   R .   K i d n e y A b s o l u t e 0 . 1 9 5   ±   0 . 0 0 5 0 . 1 9 7   ±   0 . 0 0 4 0 . 1 9 7   ±   0 . 0 0 5 0 . 1 8 9   ±   0 . 0 0 4   R e l a t i v e 0 . 6 4 2   ±   0 . 0 1 7 0 . 6 5 4   ±   0 . 0 2 4 0 . 6 8 4   ±   0 . 0 1 3 0 . 6 6 9   ±   0 . 0 1 5   L i v e r A b s o l u t e 1 . 2 5 0   ±   0 . 0 2 6 1 . 2 8 0   ±   0 . 0 3 4 1 . 2 5 6   ±   0 . 0 3 7 1 . 2 9 2   ±   0 . 0 4 2   R e l a t i v e 4 . 1 1 9   ±   0 . 1 0 1 4 . 2 2 8   ±   0 . 0 9 2 4 . 3 6 5   ±   0 . 1 1 8 4 . 5 6 9   ±   0 . 1 3 6 *   L u n g A b s o l u t e 0 . 2 1 6   ±   0 . 0 0 5 0 . 2 9 9   ±   0 . 0 0 8 * * 0 . 3 7 8   ±   0 . 0 2 0 * * 0 . 4 7 8   ±   0 . 0 1 8 * *   R e l a t i v e 0 . 7 1 3   ±   0 . 0 2 5 0 . 9 9 3   ±   0 . 0 4 0 * * 1 . 3 1 3   ±   0 . 0 6 4 * * 1 . 6 9 0   ±   0 . 0 5 9 * *   T h y m u s A b s o l u t e 0 . 0 4 4   ±   0 . 0 0 2 0 . 0 4 5   ±   0 . 0 0 2 0 . 0 4 2   ±   0 . 0 0 2 0 . 0 4 3   ±   0 . 0 0 3   R e l a t i v e 0 . 1 4 4   ±   0 . 0 0 6 0 . 1 4 8   ±   0 . 0 0 7 0 . 1 4 6   ±   0 . 0 0 7 0 . 1 5 3   ±   0 . 0 1 0   * S i g n i f i c a n t l y   d i f f e r e n t   ( P # 0 . 0 5 )   f r o m   t h e   c h a m b e r   c o n t r o l   g r o u p   b y   W i l l i a m s ’   o r   D u n n e t t ’ s   t e s t * * P # 0 . 0 1 a O r g a n   w e i g h t s   ( a b s o l u t e   w e i g h t s )   a n d   b o d y   w e i g h t s   a r e   g i v e n   i n   g r a m s ;   o r g a n - w e i g h t - t o - b o d y - w e i g h t   r a t i o s   ( r e l a t i v e   w e i g h t s )   a r e   g i v e n   a s g   o r g a n   w e i g h t / g   b o d y   w e i g h t   a s   a   p e r c e n t a g e   ( m e a n   ±   s t a n d a r d   e r r o r ) . 2 9 0 I n d i u m   P h o s p h i d e ,   N T P   T R   4 9 9 2 9 1 A P P E N D I X   H T I S S U E   B U R D E N   R E S U L T S L U N G   D E P O S I T I O N   A N D   C L E A R A N C E   E Q U A T I O N S . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 2 T A B L E   H 1 L u n g   W e i g h t   a n d   L u n g   B u r d e n   i n   M a l e   R a t s   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 3 T A B L E   H 2 L u n g   W e i g h t   a n d   L u n g   B u r d e n   i n   A g e - M a t c h e d   M a l e   R a t s   a f t e r   5   D a y s   o f   E x p o s u r e t o   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 4 T A B L E   H 3 L u n g   D e p o s i t i o n   a n d   C l e a r a n c e   P a r a m e t e r s   w i t h   E r r o r   E s t i m a t e s   a n d   9 5 %   C o n f i d e n c e   I n t e r v a l s   f o r   M a l e   R a t s   D u r i n g   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 5 T A B L E   H 4 L u n g   C l e a r a n c e   P a r a m e t e r s   w i t h   E r r o r   E s t i m a t e s   a n d   9 5 %   C o n f i d e n c e   I n t e r v a l s f o r   M a l e   R a t s   F o l l o w i n g   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . 2 9 6 T A B L E   H 5 L u n g   C l e a r a n c e   P a r a m e t e r s   w i t h   E r r o r   E s t i m a t e s   a n d   9 5 %   C o n f i d e n c e   I n t e r v a l s   f o r   A g e - M a t c h e d   M a l e   R a t s   a f t e r   5   D a y s   o f   E x p o s u r e   t o   I n d i u m   P h o s p h i d e . . . . . . . . . . . . 2 9 7 T A B L E   H 6 B l o o d   I n d i u m   C o n c e n t r a t i o n s   i n   M a l e   R a t s   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 8 T A B L E   H 7 S e r u m   I n d i u m   C o n c e n t r a t i o n s   i n   M a l e   R a t s   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 8 T A B L E   H 8 T e s t i s   I n d i u m   C o n c e n t r a t i o n s   i n   R a t s   i n   t h e   1 4 - W e e k   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 9 T A B L E   H 9 S t u d y   D e s i g n   f o r   t h e   R a t   T i s s u e   B u r d e n   a n d   C l e a r a n c e   S t u d y i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 9 T A B L E   H 1 0 L u n g   W e i g h t   a n d   L u n g   B u r d e n   i n   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 0 0 T A B L E   H 1 1 L u n g   D e p o s i t i o n   a n d   C l e a r a n c e   P a r a m e t e r s   w i t h   E r r o r   E s t i m a t e s   a n d   9 5 %   C o n f i d e n c e   I n t e r v a l s   f o r   M a l e   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 0 2 T A B L E   H 1 2 S e r u m   I n d i u m   C o n c e n t r a t i o n s   i n   R a t s   i n   t h e   2 - Y e a r   I n h a l a t i o n   S t u d y   o f   I n d i u m   P h o s p h i d e . . . . . . . . . .