298. 302 309. 321. 328. 324. SCHEDULED EUTH WEEK 13 285. 287 292. 307. 312. 322. SCHEDULED EUTH WEEK 13 275. 282 292. 303. 305. 311. SCHEDULED EUTH WEEK 13 261. 312. 281. 302. 271. 282. 281. 266 261. 276. 284. 285. SCHEDULED EUTH WEEK 13 320 318. 335. 340. 345. SCHEDULED EUTH WEEK 13 278 261. 288. 296. 304. SCHEDULED EUTH WEEK 13 313 287. 328. 334. 328. SCHEDULED EUTH WEEK 13 289 267. 297. 301. 304. SCHEDULED EUTH WEEK 13 288 277. 298. 306. 308. SCHEDULED EUTH WEEK 13 290 295. 234. 269. 294. SCHEDULED EUTH WEEK 13 WEEK   _ _      ANIMAL 69305 69316 69320 69323 69326 69335 69336 69338 69345 69347 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE __ 6 7 _________

241. 250. 291. 304.

MEAN 217. 290. 300. 306. 300. 320. 326. 329. S. D. 20.0 21.4 20.0 19.3 23.6 23.3 23.4 25.5 N 10 10 10 10 10 10 10 10 282. 302. 291. 301. 307. 319. 293. 305. 268. 285. 259. 270. 282. 295. 260. 267. TABLE 21 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHTS [G]

MALE GROUP: 15 PPM 8 9 10 11 12 13 _______________________________________~~

266. 271. 269, 280. 283. 282. 316. 317. 301. 330. 338. 342. 312. 323. 325. 331. 336. 338. 313. 317. 314. 334. 339. 345. 323. 329. 328. 354. 358. 364. 314. 316. 324. 339. 344. 351. 291. 305. 282. 314. 326. 327. 278. 286. 263. 295. 299. 301. 308. 315. 308. 324. 330. 335. 277. 284. 289. 294. 302. 304. PAGE 6 __.

SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE 90 DAY INHAL. STUDY OF 1,2,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHTS [G]

WEEK 6 7 8 _  _ _ _ _ _  _ _  . ANIMAL 69303 69309 69313 69315 69324 69328 69339 MALE 9 _______________

69344 69348 244. 287. 280. 238. 286. 294. 241. 299. 269. TABLE 21 PAGE 7 251. 296. 288. 246. 304. 308. 251. 310. 311 321 315. 332. 280. 293 298 298. 304. 254 303 301 258 317 312 257 261 253. 262. 310 319. 320. 304 301. 325. 262 265. 266. 322 315. 345. 310 321. 334. 272 276. 285. GROUP: 40 PPM 10 11 ______________ 12 _________ ___

266. 276. 321. 317. 333. 335. 273. 274. 352. 363. 341. 344, 289. 293. 326. 341. 306. 317. 13 ______

69350 263. 267. 281. 284. 275. 299. 301. 306.

MEAN 270. 280. 289. 294. 294. 307. 311. 317. S. D. 22.7 24.9 24.6 23.2 24.7 29.0 28.8 29.8 N 10 10 10 10 10 10 10 10 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK  _ _ _ _    ANIMAL 69304 69307 69318 69319 69327 69329 69332 69334 69342 69346 6 7 ______________ __.

294. 300. 316. 324 312 337 341. 349. SCHEDULED EUTH WEEK 13 293. 299. 318. 322 324 340 350. 352. SCHEDULED EUTH WEEK 13 278. 287. 295. 304 314 318 328. 334. SCHEDULED EUTH WEEK 13 272. 282. 297. 300 303 314 322. 329. SCHEDULED EUTH WEEK 13 260. 274. 281. 294 303 314 318. 327. SCHEDULED EUTH WEEK 13 260. 272. 281. 292 294 303 310. 320. SCHEDULED EUTH WEEK 13 261. 272. 278. 282 292 302 309. 318. SCHEDULED EUTH WEEK 13 271. 276. 280. 292 279 303 305. 314. SCHEDULED EVTH WEEK 13 285. 288. 300. 309 312 323 321. 330. SCHEDULED EUTH WEEK 13 274. 290. 292. 302 304 319 315. 326. SCHEDULED EUTH WEEK 13 ____ MALE GROUP: 100 PPM 8 9 10 11 12 _ _ _ _ _ _ _ _ _ 13 _

MEAN 275. 284. 294. 302. 304. 317. 322. 330. S. D. 12.8 10.5 14.5 13.4 12.9 13.4 14.3 12.4 N 10 10 10 10 10 10 10 10 TABLE 21 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE TNDJVIDUAL BODY WEIGHTS [Gl PAGE 8 TABLE 21 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHTS [G] PAGE 9 FEMALE GROUP: 0 PPM 1 0 1 2 3 4 5 ._____________________________________. PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK ___ _____. ANIMAL 69354 69366 2 .______

95. 104 114. 126 122 141 140 147 127 140 121 140 131 142 131 152 130 154 122 139 126 148 124 142 153. 158. 157. 149. 148. 162. 165. 173. 182 164. 169. 171 167. 172. 181 69367 88. 105 69378 89. 107 159. 170. 171 152. 158. 158 171. 176. 184 69384 69398 69404 69416 69419 104. 116 97. 111 89. 104 90. 104 93. 111 94. 107 164. 170. 177. 190 154. 164. 172. 180 69432 156. 168. 175. 182 153. 161. 164. 172 MEAN 95. 110. 127. 145. 155. 164. 171. 177. S. D. 8.1 7.0 5.8 5.4 5.1 5.7 5.8 9.1 N 10 10 10 10 10 10 10 10 TABLE 21 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH SPONSOR: HAP TASK FORCE INDIVIDUAL BODY WEIGHTS [G]

WEEK  _ _ _ _ _ _ _ _ ANIMAL 69362 69376 69377 69382 69390 69393 69396 69409 69413 69435 _ 2 ._____  _____

107. 116. 131. 145. 157. 164. 166. 176. 106. 116. 130. 143. 145. 153. 160. 165. 95. 107. 126. 140. 151. 162. 168. EUTH IN EXTREMIS WEEK 4 90. 106. 130. 146. 163. 173. 180. 184. 108. 116. 134. 146. 154. 162. 173. 170. 109. 116. 137. 144. 151. 157. 159. 165. 92. 104. 123. 145. 156. 165. 171. 182. 87. 100. 122. 138. 149. 158. 168. 172. 84. 96. 118. 126. 138. 143. 152. 158. 92. 107. 124. 140. 151. 157. 166. 172. 1 0 _  _ _  _ _ _ _ _  _ FEMALE GROUP: 15 PPM 1 2 3 .__________________ ____ PK IN RATS & MICE PAGE 10 4 5 _____________

MEAN 97. 108. 128. 141. 152. 159. 166. 172. S. D. 9.5 7.3 5.9 6.1 6.8 8.0 7.9 8.3 N 10 10 10 10 10 10 10 9 TABLE 21 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 11 SPONSOR: HAP TASK FORCE INDIVIDUAL BODY WEIGHTS [G]

WEEK ________ ANIMAL 69359 69369 69370 69380 69388 69394 69426 69428 69433 112. 90. 116. 102. 107. 111. 102. 99. 131 119 126 130 122 121 146. 154. 165. 176. 137. 148. 156. 160. 138 150. 159. 168. 69436 85. 138 149. 159. 171.

MEAN 98. 109. 128. 140. 149. 159. 167. S. D. 9.6 6.6 6.1 5.9 9.1 7.5 9.0 N 10 10 10 10 10 10 10 2 ___

105. 112. 126 105. 115. 135 104. 92. 109. 91. 90. 1 117. 104. 0 ____

138 128 FEMALE GROUP: 1 2 ____________________________

129 129. 148. 152. 147 156. 166. 174. 147 161. 167. 173. 144 158. 169. 3.76. 139 144. 150. 154. 135 145. 152. 162. 40 PPM 3 4 ________

160. 178. 178. 180. 163. 171. 182. 167. 171. 179.

173. 7.7 10 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE INDIVIDUAL BODY WEIGHTS IGI WEEK __________

ANIMAL 69375 69379 92 69383 87 69385 97 69392 104 69402 96 69408 91 69415 86 69427 88 69431 88 2 ___

109 MEAN 94. S. D. 7.7 N 10 NA = NOT APPLICABLE TABLE 21 FEMALE GROUP: 100 PPM 1 0 1 2 3 4 ________________________________________

120. 138. 143. 145. 153 156. 106. 130. 137. 145. 153 160. 96. 121. 134. 141. 149 163. 108. 129. 140. 157. 165 174. 115. 131. 133. 138. 147 149. 111. 131. 139. 153. 158 172. 104. 126. 143. 156. 161 167. 102. 120. 136. 149. 163 172. 104. 125. 135. 145. 157 NA 104. 123. 134. 149. 161 165.

107. 127. 137. 148. 157. 164. 6.9 5.5 3.7 6.2 6.0 8.2 10 10 10 10 10 9 PAGE 12 5 __________

163. 169. 171. 175, 157. 180. 177. 178. 165. 176.

171. 7.5 10 TABLE 21 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 13 SPONSOR: HAP TASK FORCE INDIVIDUAL BODY WEIGHTS [Gl FEMALE GROUP: 0 PPM WEEK 6 7 8 9 10 11 12 13 ________________________________________ ANIMAL 69354 189. 197. 199. 204. 202. 214. 215. 218. SCHEDULED EUTH WEEK 13 69366 172. 182. 117. 184. 187. 193. 195. 194. SCHEDULED EUTH WEEK 13 69367 181. 193. 192, 195. 191. 199. 207. 209. SCHEDULED EUTH WEEK 13 69378 180. 182. 184. 183. 183. 198. 198. 199. SCHEDULED EUTH WEEK 13 69384 l. 66. 171. 172. 171. 179. 180. 181. 185. SCHEDULED EUTH WEEK 13 69398 190. 196. 195. 203. 196. 210. 213. 212. SCHEDULED EUTH WEEK 13 69404 193. 199. 200. 204. 194. 214. 212. 214. SCHEDULED EUTH WEEK 13 69416 184. 193. 196. 204. 198. 207. 209. 209. SCHEDULED EUTH WEEK 13 69419 189. 194. 201. 204. 192. 209. 209. 211. SCHEDULED EUTH WEEK 13 69432 179. 182. 185. 191. 183. 148. 177. 195. SCHEDULED EUTH WEEK 13 MEAN 182. 189. 190. 194. 191. 197. 202. 205. S. D. 8.5 9.1 10.1 11.7 1.4 20.3 13.5 10.7 N 10 10 10 10 10 10 10 10 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 6 .__ ___ 7 8 FEMALE GROUP: 15 PPM 9 10 11 12 13 _  _  _ _ _   _ _ .

ANIMAL 69362 69376 69382 69390 69393 69396 69409 69413 69435 _

117. 182. 186. 191. 191. 194. 188. 196. SCHEDULED EUTH WEEK 13 165. 171. 173. 180. 166. 181. 179. 181. SCHEDULED EUTH WEEK 13 187. 188. 193. 201. 195. 208. 208. 213. SCHEDULED EUTH WEEK 13 179. 176. 183. 188. 182. 194. 192. 200. SCHEDULED EUTH WEEK 13 167. 166. 172. 173. 171. 175. 111. 183. SCHEDULED EUTH WEEK 13 182. 190. 193. 198. 190. 202. 203. 201. SCHEDULED EUTH WEEK 13 180. 182. 186. 189. 184. 192. 197. 196. SCHEDULED EUTH WEEK 13 164. 168. 171. 182. 183. 192. 191. 189. SCHEDULED EUTH WEEK 13 176. 179. 184. 187. 191. 193. 194. 196. SCHEDULED EUTH WEEK 13 MEAN 175. 178. 182. 188. 184. 192. 192. 195. S. D. 8.1 8.5 8.5 8.7 9.7 9.8 10.1 9.8 N 9 9 9 9 9 9 9 9 TABLE 21 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH INDIVIDUAL BODY WEIGHTS [G] PK IN RATS & MICE PAGE 14 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE 6 ____ WEEK _____ ___ ANIMAL 69359 69369 69370 69380 69388 69394 69426 69428 69433 69436 160. 166. 179. 186. 179. 188. 185. 191. 165. 170. 172. 174. 188. 186. 166. 172. 176. 178. 181. 187.

MEAN 175. 180. 185. 188. 188. 195. 197. 199. S. D. 9.1 8.9 9.9 11.5 10.3 10.8 11.9 11.8 N 10 10 10 10 10 10 10 10 TABLE 21 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHTS [G]

FEMALE GROUP: 40 PPM 7 8 9 10 11 12 13 _________

172. 188. 193. 197. 174. 179. 194. 175. 179. 196. 171. 177 183 184 181 SCHEDULED EUTH WEEK 13 194. 183 198 201 201 SCHEDULED EUTH WEEK 13 196. 200 197 204 206 SCHEDULED EUTH WEEK 13 206. 202 212 214 216 SCHEDULED EUTH WEEK 13 176. 182 184 181 188 SCHEDULED EUTH WEEK 13 184. 184 191 194 196 SCHEDULED EUTH WEEK 13 199. 197 209 208 212 SCHEDULED EUTH WEEK 13 175. 177 180 182 185 SCHEDULED EUTH WEEK 13 186. 178 194 194 197 SCHEDULED EUTH WEEK 13 193. 199 201 208 208 SCHEDULED EUTH WEEK 13 PAGE 15 WEEK _ _ _ _ _  _  _ ANIMAL 69375 69379 63383 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE __ 6 7 ________

69385 69392 69402 69408 69415 69427 69431 166. 170. 175. 171. 176. 181. 176. 176. 178. 180. 181. 184. 157. 162. 169. 184. 184. 187. 181. 181. 188. 182. 186. 186. 176. 177. 180. 181. 184. 191. 194. 198. 197. 189. 182. 178. 189. 195. 193. 193. 199. SCHEDULED EUTH WEEK 13 198. 198. 203. SCHEDULED EUTH WEEK 13 178. 174. 179. SCHEDULED EUTH WEEK 13 199. 201. 204. SCHEDULED EUTH WEEK 13 199. 201. 198. SCHEDULED EUTH WEEK 13 197. 200'. 199. SCHEDULED EUTH WEEK 13 186. 190. 198. SCHEDULED EUTH WEEK 13 198. 201. 199. SCHEDULED EUTH WEEK 13 MEAN 175. 178. 182. 187. 185. 192. 193. 196. S. D. 8.5 7.3 6.7 7.9 9.4 7.8 9.6 8.2 N 10 10 10 10 10 10 10 10 TABLE 21 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHTS [Gl FEMALE GROUP: 8 9 10 _____ __________________ ___ 100 PPM 11 12 13 ______________

177. 173. 185. 184. 186. 177. 193. 197. 172. 175. 191. 188. 181. 179. 183. SCHEDULED EUTH WEEK 13 193. 19s. 198. SCHEDULED EUTH WEEK 13 PAGE 16 PBFTSv4.24 05/ 01/ 2002 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 2 ___ ANIMAL 69302 69306 69308 69310 69312 69314 69317 69322 69337 69343 TO 1 1 _________

25. 29. 26. 26. 26. 27. 29. 24. 22. 22. TO 0 38. 37. 42. 34. 42. 35. 45. 39. 36.

MEAN 26. 39. 30. 18. 18. 13. 9. 10. S. D. 2.5 3.5 7.6 6.9 2.2 2.1 6.1 5.4 N 10 10 10 10 10 10 10 10 TABLE 22 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHT CHANGES [G] PAGE 1 MALE GROUP: 0 PPM OTO 1 1TO 2 2T0 3 3T0 4 4T0 5 5T0 6 ._________________________________~~~

40. 20 18 13 6 14 41. 15 21 15 11 10 25. 4 23 11 15 9 15. 22 17 9 5 12 30. 28 18 13 4 22 25. 14 16 14 12 3 32. 23 18 14 11 14 34. 25 18 15 12 29. 14 17 10 15 8 28. 18 16 14 11 5 TABLE 22 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF l, l., 2 TCE IN RATS WITH SPONSOR: HAP TASK FORCE INDIVIDUAL BODY WEIGHT CHANGES MALE GROUP: 15 PPM WEEK 2 TO 1 lTO 0 OTO 1 1TO 2 2T0 3 3T0 4 ___________ ANIMAL 69305 69316 69320 69323 69326 69335 17. 69336 26. 69338 27. 69345 23. 69347 23. 23. 27. 31. 27. 24. 35 26 43 36 43 28 40 35 46 36 45 39 39 28 36 30 31 37 38 29 19 27 23 24 30 26 29 18 29 18 15. 22. 16. 24. 26. 13. 12. 15. 22. 19. 8. 15. 10. 17. 16. 35. 13. 9. 14. 11.

MEAN 25. 40. 32. 24. 16. 15. 9. 11. S. D. 3.7 4.8 4.6 4.7 11.1 7.7 4.7 5.6 N 10 10 10 10 10 10 10 10 PK IN RATS & MICE [Gl PAGE 2 4T0 5 5T0 6 ______

7. 1. 9. 13. 10. I. 5. 15. 7. 16. 21. 17. 5. 6. 11. 5. 11. 12. 6. 16. TABLE 22 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1.1.2 TCE IN RATS WITH PK IN RATS & MICE PAGE 3 SPONSOR: HAP TASK FORCE INDIVIDUAL BODY WEIGHT CHANGES [Gl MALE GROUP: 40 PPM WEEK 2 TO 1 lTO 0 OTO 1 1TO 2 2T0 3 3T0 4 4T0 5 _______________________________________ ANIMAL 69303 23. 36. 15. 20. 18. 12. 11. 69309 28. 40. 41. 22. 19. 14. 9. 69313 25. 45. 33. 22. 23. 16. 4. 69315 18. 33. 22. 19. 14. 9. 4. 69324 22. 39. 26. 26. 24. 18. 16. 69328 22. 42. 32. 22. 25. 15. 14. 69339 23. 37. 22. 17. 11. 5. 14. 69344 28. 46. 27. 21. 17. 17. 11. 69348 25. 37. 29. 23. 14. 15. 12. 69350 24. 39. 26. 23. 17. 10. 9.

MEAN 24. 39. 27. 22. 18. 13. 10. S. D. 3.0 4.0 7.1 2.5 4.6 4.1 4.0 N 10 10 10 10 10 10 10 s ul % m G 5T0 6 8. 13. 8. 13. 9. l. 1. 9. 15. 0. 8.

9. 4.1 10 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 22 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHT CHANGES [G]

WEEK 2 TO 1 1 ______________________ ANIMAL 69304 29. 69307 24. 69318 24. 69319 22. 69327 27. 69329 23. 69332 23. 69334 25. 69342 25. 69346 25. TO 0 OTO 1 39. 37. 28. 41. 34. 25. 38. 23. 25. 39. 29. 27. 39. 17. 21. 39. 18. 19. 37. 22. 24. 40. 20. 24. 35. 34. 28. 41. 34. 23. MALE 1TO 2 GROUP: 100 PPM 2T0 3 3T0 4 ____  ______ _ _    _  _ _ _ _ _

23. 12. 19. 17. 21. 18. 23. 13. 15. NA 17. 9. 16. 11. 12. 15. 18. 11. 17. 18. 4T0 5 .__ ___ ___.

18. 15. 10. 17. NA 17. 11. 9.

12. 9. 5 TO 6 8 13 15 7 13 10 5 11 7 12 MEAN 25. 39. 27. 24. 18. 14. 13. 10. S. D. 2.1 1.8 7.6 2.9 3.5 3.3 3.7 3.2 N 10 10 10 10 10 9 9 10 NA = NOT APPLICABLE PAGE 4 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 6 ___________ ANIMAL 69302 69306 69308 69310 69312 69314 69317 69322 69337 69343 TO 7 7 14. 11. 7. 14. 15. 16. 12. 10. 10. 12. TO 8 ______ __

12. 4. 3. 6. I. 12. 1. 3. 13. 5.

MEAN 12. 5. 7. 6. 13. 9. 5. S. D. 2.7 6.3 5.6 12.8 27.6 9.4 8.6 N 10 10 10 10 10 10 10 TABLE 22 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHT CHANGES [G] PAGE 5 MALE GROUP: 0 PPM 8T0 9 9TO 10 10 TO 11 11 TO 12 I. 2 TO 13 ._____________________________________

4. 7. 12. 7. 4. SCHEDULED EUTH WEEK 13 2. 5. 15. 5. 10. SCHEDULED EUTH WEEK 13 7. 10. 11. 2. 6. SCHEDULED EUTH WEEK 13 5. 5. 15. 8. 1. SCHEDULED EUTH WEEK 13 8. 2. 17. 5. 5. SCHEDULED EUTH WEEK 13 3. 17. 27. 8. 8. SCHEDULED EUTH WEEK 13 11. 26. 41. 6. 6. SCHEDULED EUTH WEEK 13 18. 22. 30. 4. 3. SCHEDULED EUTH WEEK 13 6. 11. 21. 8. 2. SCHEDULED EUTH WEEK 13 9. 5. 61. 35. 25. SCHEDULED EUTH WEEK 13 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 6T0 7 _______ ANIMAL 69305 9. 69316 13. 69320 20. 69323 10. 69326 12. 7T0 a  _ _ _ _ _ _ _

16. 5. 2. 11. 3. 12. 1. 16. 29. 8. 10. 11. 2. 6. 5. 12. 4. 3. 20. 5. 4. 6. 1. 26. 4. 9. 2. 8. 15. 5. 6. 14. 23. 32. 12. 8. 8. 23. 32. 4. 13. 7. 7. 16. 6. 10. 7. 5. 5. 8. 69335 12. 69336 17. 69338 11. 69345 13. 69341 I.

MEAN 12. S. D. 3.8 N LO 8T0 9 ___ MALE GROUP: 15 PPM 9TO 10 10 TO 11 11 TO 12 _____________________ __________ _ 12 TO 13 1. 4. 2. 6. 6. 7. 1. 2. 5. 2.

10. 7. 6. 19. 6. 3. 3.5 3.9 11.1 10.2 2.7 2.6 10 10 10 10 10 10 TABLE 22 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHT CHANGES [G] PAGE 6 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 1; SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE ANIMAL 69303 69309 69313 69315 69324 69328 69339 69344 69348 69350 6T0 I 7. 3. 7. 9. 7. 7. 8. 13. 3. 8. 12. 4. 18. 13. 5. 14. 4. 2. 10. 6. 15. 11. 1. 10. 11. 13. 5. 4. 14. 3. 7T0 8    _   _ _

MEAN 10. 9. 6. S. D. 3.9 4.9 4.5 N 10 10 10 TABLE 22 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHT CHANGES [G]

MALE GROUP: 40 PPM 9TO 10 10 TO 11 11 TO 12 ______________ ___________

8. 9. 9. 1. 3. 24. 3. 1. 7. 30. 11. 13. 4. 9. 6. 17. 0. 6. 9. 24.

1. 13. 7.2 10.1 10 10 4. 10. 1. 4. 8. 2. 7. 7. 7. 3. 4. 4. 6. 15. 2. 11. 2. 5.

4. 6. 4.2 5.8 10 10 12 TO 13 _____.

1. 11. PAGE 7 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 6TO 7 ANIMAL 69304 6. 69307 6. 69318 9. 69319 10. 69327 14. 69329 12. 69332 11. 69334 5. 69342 3. 69346 16.

MEAN 9. S. D. 4.2 N 10 7T0 8 8T0 9   _ _ _ _ _ _ _________ MALE GROUP: 100 PPM 9TO 10 10 TO 11 11 TO 12 12 TO 13 _____________________________________

16. 8. 19. 4. 8. 9. 15. 3. 7. 13. 9. 11. 6. 4. 4. 12. 12. 9. 2. 10. 12. 2. 10. 3. 4 10 9. 2. 25. 16. 4. 11. 11. 9. 10. 24. 10 8 8 2 4 10. 13. 3. 2. 11. 15. 2 2 4 9 10 9 9 9 11 10. 8. 2. 14. 5. 8. 5.5 3.5 8.2 6.6 4.8 2.5 10 10 10 10 10 10 TABLE 22 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHT CHANGES [G] PAGE 8 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 TABLE 22 PROJECT NO.: WIL 417002 go DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HA?? TASK FORCE INDIVIDUAL BODY WEIGHT CHANGES [G]

WEEK 2 __________ ANIMAL 69354 69366 69367 69378 69384 69398 69404 69416 69419 69432 TO 1 ____

9. 18 19 12. 12. 8. 9. 7. 12. 14 7 11. 6. 5. 2. 1. 17. 22 13 17. 10. 5. 9. 0. 18. 14 19 9. 10. 11. 1. 9. 12. 15 11 6. 4. 6. 0. 8. 14. 20 21 10. 9. 5. 8. 6. 15. 26 24 10. 6. 7. 13. 3. 14. 18 17 15. 10. 8. 8. 4. 18. 15 22 8. 12. 7. 7. 7. 13. 17 18 11. 8. 3. 8. 7. 1 TO 0 0 TO FEMALE GROUP: 0 PPM 1 1TO 2 2T0 3 3T0 4 _________ 4T0 5 PAGE 9 MEAN 14. 18. 17. 11. 9. 7. 7. 5. S. D. 2.9 3.9 5.3 3.2 2.7 2.2 4.1 3.0 N 10 10 10 10 10 10 10 10 5T0 6 ____________________________________ PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 2 _  __. ANIMAL 69362 69376 69377 69382 69390 69393 69396 69409 69413 69435 TO 1 lTO 0 OTO 1 ._________________ _____

9. 15. 14. 10. 14. 13. 12. 19. 14. 16. 24. 16. 8. 18. 12. 7. 21. 7. 12. 19. 22. 13. 22. 16. 12. 22. 8. 15. 17. 16.

MEAN 11. 19. 14. 10. 8. 7. 5. 4. S. D. 2.9 3.2 1.3 i. 9 1.9 3.1 4.0 3.4 N 10 10 10 10 10 10 9 9 TABLE 22 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 10 INDIVIDUAL BODY WEIGHT CHANGES [Gl FEMALE GROUP: 15 PPM 1TO 2 2T0 3 3T0 4 ________________   _  _ _ _

12. I. 2. 8. 11. 11. 11. 10. 8. 8. 7. 6. 11. 9. 11. 9. 12. 5. 11. 6. 2. 10. 1 7. 5. 0 6. EUTH IN EXTREMIS I. 4. 3 11. 3. 9 2. 6. 2 6. 11. 0 10. 4. 8 9. 6. 6 9. 6. 4 4T0 5 5T0 6 .____________________________________

WEEK 4 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 22 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHT CHANGES [G]

WEEK 2 TO 1 1 ___________

ANIMAL 69359 7. 69369 10. 69370 13. 69380 12. 69388 7. 69394 11. 69426 17. 69428 1. 69433 12. 69436 14. TO 0 OTO 1 1 _ _ _   _    _______.

14. 3. 0. 19. 4. 8. 0. 20. 12. 9. 10. 8. 4. 1. 21. 9. 14. 6. 6. 5. 1. 24. 16. 14. 11. 7. 4. 5. 15. 8. 5. 6. 4. 9. 2. 17. 16. 10. 7. 10. 9. 1. 19. 20. 8. 11. 11. 6. 6. 19. 7. 11. 8. 4. 7. 1. 20. 16. 12. 9. 9. 3. 5. 22. 17. 11. 10. 12. 8. 2. FEMALE GROUP: TO 2 2T0 3 40 PPM 3T0 4 _______ PAGE 11 4T0 5 5T0 6 ______

MEAN 10. 19. 12. 9. 10. 8. 6. 2. S. D. 5.0 3.1 5.4 4.3 3.8 3.0 2.2 2.3 N 10 10 10 10 10 10 10 10 TABLE 22 PROJECT NO.: WIL 417002 PO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE INDIVIDUAL BODY WEIGHT CHANGES [G] PAGE 12 WEEK 2 TO 1  ___________________ ANIMAL 69375 11. 69379 14. 69383 9. 69385 11. 69392 11. 69402 15. 69408 13. 69415 16. 69427 16. 69431 16. 1TO 0 OTO 1 _____________________

18. 5. 2. 8. 3. 7. 3. 24. 7. 8. 8. 7. 9. 2. 25. 13. 7. 8. 14. 8. 5. 21. 11. 17. 8. 9. 1. 5. 16. 2. 5. 9. 2. 8. 0. 20. 8. 14. 5. 14. 8. 4. 22. 17. 13. 5. 6. 10. 4. 18. 16. 13. 14. 9. 6. 4. 21. 10. 10. 12. NA NA 11. 19. 11. 15. 12. 4. 11. 5. FEMALE GROUP: 100 PPM 1TO 2 2T0 3 3T0 4 4T0 5 5T0 6 ,_______ ________________~

MEAN 13. 20. 10. 10. 9. 8. 8. 4. S. D. 2.6 2.8 4.7 4.8 3.0 4.4 2.9 2.8 N 10 10 10 10 10 9 9 10 NA = NOT APPLICABLE PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF l, L, 2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE INDIVIDUAL BODY WEIGHT CHANGES [G]

TO WEEK 6 _ _ _ _  _ _ _ _ _ ANIMAL 69354 69366 69367 69378 69384 I 7T0 8 ___________

8 2. 10 5. 12 1. 2 2. 5 1. 69398 1. 69404 6 1. 69416 9 3. 69419 5 7. 69432 3. 5. 2. 12. 1. 3. SCHEDULED EUTH WEEK 13 7. 3. 6. 2. 1. SCHEDULED EUTH WEEK 13 3. 4. 8. 8. 2. SCHEDULED EUTH WEEK 13 1. 0. 15. 0. 1. SCHEDULED EUTH WEEK 13 1. 8. 1. 1. 4. SCHEDULED EUTH WEEK 13 8. 7. 14. 3. 1. SCHEDULED EUTH WEEK 13 4. 10. 20. 2. 2. SCHEDULED EUTH WEEK 13 8. 6. 9. 2. 0. SCHEDULED EUTH WEEK 13 3. 12. 17. 0. 2. SCHEDULED EUTH WEEK 13 6. 8. 35. 29. 18. SCHEDULED EUTH WEEK 13 MEAN 7. 1. 4. 4. 7. 4. 3. S. D. 3.1 3.2 3.3 6.2 15.7 9.0 5.5 N 10 10 10 10 10 10 10 TABLE 22 PAGE 13 FEMALE GROUP: 0 PPM 8TO 9 9TO 10 10 TO 11 11 TO 12 12 TO 13 ____________________________________ PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 6 __________

ANIMAL 69362 69376 69382 69390 69393 69396 69409 69413 69435 TO 7 7TO a 5. 4. 6. 2. 1. 5. 3. 7. 1. 6. 8. 3. 2. 4. 4. 3. 3. 5.

MEAN 3. 4. 5. 4. S. D. 3.5 1.6 3.0 5.4 N 9 9 9 9 TABLE 22 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS t MICE INDIVIDUAL BODY WEIGHT CHANGES [G] PAGE 14 FEMALE GROUP: 15 PPM 8TO 9 PTO 10 10 TO 11 11 TO 12 12 TO 13 ________________~~

5. 0. 7. 14. 15. a. 6. 13. 5. 6. 1. 2. 5. 8. 3. 5. 11. 1. 3. 4. 3.

12. 4. 12. 8. 9. 2.

9. 4.1 9 6. 2. 0. 2. 2. 1. 5. 1. 1.

0. 3.1 9 a. 2. 5. a. 6. 2. 1. 2. 2.

3. 4.0 9 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 6T0 7 7T0 8 ___________________________ ANIMAL 69359 6. 6. 69369 7. 2. 69370 9. 5. 69380 6. 6. 69388 5. 4. 69394 2. 5. 69426 2. 8. 69428 6. 3. 69433 2. 1. 69436 6. 9. 1. 6. 6. 1. 6. 11. 15. 3. 3. 4. 3. I. 9. 4. 10. 2. 2. 6. 2. 3. 5. 0. 7. 3. 5. 2. 12. 1. 0. 2. 3. 2. I. 8. 16. 0. 3. 6. 2. 7. 3. SCHEDULED EUTH WEEK 13 0. SCHEDULED EUTH WEEK 13 MEAN 5. 5. 3. 0. 7. 2. 2. S. D. 3.2 2.5 3.8 6.1 6.2 3.2 2.7 N 10 10 10 10 10 10 10 TABLE 22 90 DAY INHAL. STUDY OF 1.1.2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL BODY WEIGHT CHANGES EGI PAGE 15 ET0 9 ____ FEMALE GROUP: 40 PPM 9TO 10 10 TO 11 11 TO 12 ___________________________ 12 TO 13 _____________________________________

3 0 2 2 7 2 4 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 22 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 16 INDIVIDUAL BODY WEIGHT CHANGES [G]

WEEK     _ _ _  _ ANIMAL 69375 69379 69383 69385 69392 69402 69408 69415 69427 69431 6T0 7 7 TO 8 8 TO _______ __________

4. 5. 0. 1. 5. 0. 0. 4. 1. 3. 5. 2 4. 8. 2. 5. 4 1. 9. 2. 2. 8 9. 16. 0. 3. 9 4. 1. 0. 7. 3 3. 3. 4. 3. 4 3. 11. 2. 7. 6 4. 1. 2. 0. 11 8. 8. 3. 3. 2 4. 8. 4. 7. 2 6. 3. 3. FEMALE GROUP: 100 PPM 9 9TO 10 10 TO 11 11 TO 12 _______________________ ___ 12 TO 13 _   _ _ _  _ _ _ _ _

4: 3. 6. 5. 5. 3. 3. 1. 8. 2. SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 MEAN 2. 4. S. D. 2.1 2.4 N 10 10 5. 1. I. 1. 3. 3.9 5.3 4.8 2.5 3.6 10 10 10 10 10 PBFTSv4.24 05/ 01/ 2002 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 23 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY] PAGE 1 WEEK 1 _________ ANIMAL 69302 69306 69308 69310 69312 69314 69317 69322 69337 69343 TO 0 16. 16. 17. 18. 17. 17. 17. 15. 16. 17. OTO 1 1 TO 2 ______________ ____

19. 19. 19. 18. 20. 17. 19. 20. 19.

MEAN 17. 19. 17. 17. 16. 17. 17. 17. S. D. 0.8 0.9 1.1 0.5 0.7 1.2 1.1 1.0 N 10 10 10 10 10 10 10 10 18. 17. 17. 15 18. 17. 17. 17 17. 16. 16. 17 17. 16. 15. 14 19. 17. 17. 17 15. 16. 16. 16 18. 17. 17. 17 17. 17. 17. 17 17. 16. 16. 17 18. 17. 16. 18 MALE GROUP: 2T0 3 3T0 4 ______________ ___ 0 PPM 4 TO _ _ _ _ _ _ _ 5 5T0 6 6T0 7 _________ ___________________________________

17. 17. 16. 16. 19. 15. 17. 16. 17. 16. 18. 18. 17. 16. 19. 17. 18. 16. 16. 17. PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 1 ______. ANIMAL 69305 69316 69320 69323 69326 69335 69336 69338 69345 69347 TO 0 0       _ _ _ _ _ _ MALE GROUP: 15 PPM TO 1 1TO 2 2TO 3 3T0 4 4T0 5 5T0 6 ._______________ ______

17. 18. 17. 20. 20. 21. 17. 20. 17. 21. 17. 19. 17. 20. 17. 19. 15. 19. 16. 18. TABLE 23 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY]

18. 20. 20. 19. 19. 19. 20. 18. 16 16 15. 19 17 19. 18 18 18. 18 18 19. 19 17 19. 19 19 20. 17 16 18. 16 17 17. 19. 18. 18 18 18. 17. 17. 17 17 17. 17. 18. 19. 18. 19. 10. 17. 16. 14. 18. 19. 18. 18. 18. 17. 16. 17. 16.

MEAN 17. 20. 19. 17. 18. 17. 18. 17. S. D. 1.2 1.1 1.0 2.6 1.2 0.9 1.4 1.4 N 10 10 10 10 10 10 10 10 PAGE 2 6T0 7 TABLE 23 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY]

WEEK lTO 0 _________________ ANIMAL 69303 16. 69309 18. 69313 18. 69315 16. 69324 17. 69328 17. 69339 16. 69344 18. 69348 17. 69350 17. _ OTO 1 ___ __ 1TO 2 _______ MALE GROUP: 2T0 3 3T0 4 __________ .__ 40 PPM 4T0 5 ST0 6 6T0 7 __

17. 16. 20. 20. 20. 18. 16. 16. 19. 18. 17. 18. 18. 16. 20. 19. 18. 17. 19. 17. 15. 16. 18. 18. 18. 18. 17. 16. 18. 18. 18. 18. 15. 14. 18. 18. 17. 17. 16. 16.

17. 17. 1.2 1.4 10 10 16. 15. 14. 17. 18. 3.6. 17. 17. 15. 16. 17. 16. 18. 18. 17. 18. 18. 18. 15. 16. 16. 18. 20. 18. 18. 16. 16. 17. 17. 15.

MEAN 17. 18. 18. S. D. 0.8 1.4 1.4 N 10 10 10 PAGE 3 17. 17. 16. 1.1 1.4 1.3 10 10 10 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 1 _________ ANIMAL 69304 69307 69318 69319 69327 69329 69332 69334 69342 69346 TO 0 ________

17. 18 16. 19 16. 16 16. 17 18. 18 17. 16 17. 18 17. 18 16. 19 16. 19 0 TO MEAN 17. 18. 18. 18. 17. 17. 17. 17. S. D. 0.7 1.1 0.9 1.0 1.1 0.9 0.8 0.9 N 10 10 10 10 10 10 10 10 TABLE 23 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY] PAGE 4 MALE GROUP: 100 PPM 1TO 2 2T0 3 3T0 4 4T0 5 5T0 6 .________________ __ _____ 6T0 7 .___________________________

18. 19. 16. 11. 18. 17. 11. 18. 19. 18. 19. 18. 18. 18. 17. 18. 17. 17. 17. 15. 16. 16. 17. 16. 17. 17. 19. 18. 18. 18. 18. 19. 17. 18. 17. 16. 16. 17. 18. 17. 18. 17. 18. 18. 19. 16. 17. 17. 17. 17. 17. 17. 16. 15. 17. 16. 17. 16. 18. 18. PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 23 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY] PAGE 5 MALE GROUP: WEEK 7T0 8 8T0 9 9TO 10 10 TO 11 _ ________ _. _ _ _ _      ANIMAL 69302 69306 69308 69310 69312 69314 69317 69322 69337 69343 ___ 11 TO 12 12 17. 17. 17. 15. 17. 16. 15. 16. 18. 19. 16. 15. 18. 17. 16. 16. 17. 16. 17. 17. 17. 17. 17. 17. SCHEDULED EUTH WEEK 13 16. 17. 16. 17. SCHEDULED EUTH WEEK 13 17. 17. 16. 17. SCHEDULED EUTH WEEK 13 15. 16. 17. 16. SCHEDULED EUTH WEEK 13 17. 19. 18. 18. SCHEDULED EUTH WEEK 13 15. 16. 17. 17. SCHEDULED EUTH WEEK 13 16. 16. 17. 17. SCHEDULED EUTH WEEK 13 16. 17. 15. 15. SCHEDULED EUTH WEEK 13 17. 17. 16. 17. SCHEDULED EUTH WEEK 13 17. 7. 13. 22. SCHEDULED EUTH WEEK 13 0 PPM TO 13 ______

MEAN 11. 16. 16. 16. 16. 17. S. D. 0.9 1.2 0.8 3.2 1.4 1.8 N 10 10 10 10 10 10 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 23 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY]

WEEK _      _  _

ANIMAL 69305 69316 69320 69323 69326 69335 69336 69338 69345 69347 7T0 8 8TO 9 _     _ _ _ _ _  _ _ _ _  _ _ _ _ _

15. 16. 16 16 15. 15. SCHEDULED EUTH WEEK 13 19. 19. 18 18 18. 19. SCHEDULED EUTH WEEK 13 19. 19. 19 18 18. 19. SCHEDULED EUTH WEEK 13 18. 19. 19 18 18. 19. SCHEDULED EUTH WEEK 13 19. 19. 19 19 19. 19. SCHEDULED EUTH WEEK 13 18. 19. 19 18 18. 19. SCHEDULED EUTH WEEK 13 11. 18. 11 17 17. 18. SCHEDULED EUTH WEEK 13 16. 17. 16 16 16. 16. SCHEDULED EUTH WEEK 13 18. 18. 18 18 19. 19. SCHEDULED EUTH WEEK 13 17. 17. 18 17 18. 18. SCHEDULED EUTH WEEK 13 MALE GROUP: 15 PPM 9TO 10 10 TO 11 11 TO 12 12 TO 13 _____. PAGE 6 MEAN 18. 18. 18. 18. 18. 18. S. D. 1.3 1.1 1.2 1.0 1.3 1.4 N 10 10 10 10 10 10 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY]

WEEK 7T0 0 ____________ ANIMAL 69303 14. 69309 17. 69313 17. 69315 16. 69324 18. 69328 17. 69339 16. 69344 18, 69348 17. 69350 17. __ 8T0 9 9TO 10 __ _____ ___ _____ MALE GROUP: 40 PPM 10 TO 11 11 TO 12 12 TO 13 ________________________________ .

15. 15. 17. 17. 18. 17. 17. 16. 18. 19. 18. 17. 16. 17. 18. 18. 17. 17. 18. 18. 14. 15. 14. 18. 17. 17. 18. 18. 17. 15. 16. 15. 19. 18. 20. 18. 18. 17. 17. 16. 16. 19. 19. 18. 16. 17. 18. 17. 17. 17. SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 MEAN 17. S. D. 1.2 N 10 17. 1.0 10 TABLE 23 17. 1.1 10 17. 17. 17. 1.7 1.2 1.7 10 10 10 PAGE 7 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 23 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY]

MALE GROUP: 100 PPM T"___"___"_ T'3___"____"_ '"__ 1"___ '"_ T'1~~~~~~~~~~~~~~~~~ WEEK 7 ___________ ANIMAL 69304 69307 69318 69319 69327 69329 69332 69334 69342 69346 18 18 18 18. 17. 18. 18 19 18 18. 18. 18. 17 18 18 18. 17. 18. 18 17 16 17. 17. 17. 17 18 18 18. 18. 18. 17 17 17 17. 17. 17. 17 16 17 17. 16. 17. 16 17 17 16. 16. 17. 18 18 18 18. 17. 18. 18 18 17 18. 18. 19.

MEAN 17. 18. 17. 18. 17. 18. S. D. 0.7 0.8 0.7 0.7 0.7 0.7 N 10 10 10 10 10 10 PAGE 8 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 PROJECT NG.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 1 _____ ANIMAL 69354 69366 69367 69378 69384 69398 69404 69416 69419 69432 TO 0 OTO 1 11. 12. 13. 12. 12. 13. 13. 13. 13. 12.

12. 0.7 10 13. 13. 14. 14. 12. 14. 15. 14. 14. 14.

MEAN S. D. N 1TO 2      _

12. 12. 13. 13. 12. 14. 13. 13. 13. 13.

14. 13. 0.8 0.6 10 10 TABLE 23 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 9 INDIVIDUAL FOGD'CONSUMPTION [G/ ANIMAL/ DAY]

FEMALE GROUP: 2T0 3 3T0 4 _______________

13. 13. 12. 11. 13. 13. 13. 14. 11. 12. 12. 12. 13. 12. 12. 13. 13. 14. 12. 13.

12. 13. 0.7 0.9 10 10 ___ 0 PPM 4T0 5 _ ______

13. 12. 14. 14. 11. 12. 14. 14. 14. 13.

13. 1.1 10 5T0 6 _ _______ 6T0 7

13. 12. 13. 14. 13. 14. 13. 13. 14. 13. 13. 11. 13. 13. 12. 13. 13. 14. 13. 13.

13. 13. 0.6 0.8 10 10 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 1 ANIMAL 69362 69376 69377 69382 69390 69393 69396 69409 69413 69435 TO 0 OTO 1 __ _________

12 13. 13. 13. 13. 13 14 13 12 13. 12. 12. 12. 12 12 12 12 13. 12. 13. 12. EUTH IN EXTREMIS WEEK 4 13 15. 14. 13. 13. 13 13 13 13 13. 12. 13. 13. 12 14 11 13 13. 13. 11. 11. 12 11 9 13 13. 13. 13. 12. 14 13 12 12 14. 13. 12. 13. 14 13 12 11 12. 12. 11. 11. 12 12 11 13 14. 13. 13. 13. 14 12 12 MEAN 12. 13. 13. 12. 12. 13. 13. 12. S. D. 0.7 0.8 0.7 0.8 0.8 0.9 1.0 1.2 N 10 10 10 10 10 9 9 9 TABLE 23 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY] PAGE 10 FEMALE GROUP: 15 PPM 1TO 2 2TO 3 3T0 4 4T0 5 5TO 6 6TO 7 __________~ PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 23 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY] PAGE 11 WEEK 1 _______ ANIMAL 69359 69369 69370 69380 69388 69394 69426 69428 69433 69436 TO 0 OTO 1 1TO 2 __________ ._____________________

12. 12. 13. 13. 12. 12. 13. 11. 12. 12. 11. 11. 13. 13. 13. 13. 14. 13. 11. 11. 12. 11. 13. 13. 11. 11. 13. 13. 13. 13. FEMALE GROUP: 2T0 3 3T0 4 _____________________

11. 11. 12. 12. 12. 12. 13. 12. 12. 12. 12. 12. 13. 14. 12. 12. 13. 12. 14. 13. 40 PPM 4T0 5 11. 14. 13. 13. 13. 13. 14. 12. 13. 14. 5T0 6 6T0 7 _________ .____________________________________

12. 13. 13. 14. 12. 13. 13. 12. 13. 14. 10. 12. 13. 12. 12. 11. 12. 12. 11. 14.

MEAN 12. 12. 12. 12. 12. 13. 13. 12. S. D. 0.6 1.1 1.0 0.8 0.8 0.9 0.7 1.1 N 10 10 10 10 10 10 10 10 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK lTO 0 ______________ ANIMAL 69375 12. 69379 13. 69383 12. 69385 14. 69392 11. 69402 13. 69408 12. 69415 13. 69427 13. 69431 12.

MEAN 13. S. D. 0.8 N 10 OTO 1 _ _ _ _     _ FEMALE GROUP: 1TO 2 2T0 3 3T0 4 12. 13. 11. 12. 11. 12. 13. 12. 13. 13. 12. 11. 19. 12. 12. 12. 12. 12. 12. 13. 13. 13. 11. 11. 11. 12. 13. 13. 13. 20. 12. 13. 14. 13. 13. 12. 13. 13. 13. 13.

12. 12. 13. 13. 0.8 0.7 2.6 2.2 10 10 10 10 TABLE 23 YO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL FObD'CONSUMPTION [G/ ANIMAL/ DAY]

100 PPM 4T0 5 _______

12. 13. 13. 13. 12. 14. 13. 13. 12. 14.

13. 0.7 10 5T0 6 12. 13. 12. 13. 12. 14. 13. 13. 12. 14.

13. 0.8 10 PAGE 12 6T0 7 _______________________________

10. 12. 11. 12. 10. 11. 11. 13. 11. 13.

11. 1.1 10 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 23 90 DAY INHAL. STUDY OF l, l., 2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY]

FEMALE GROUP: WEEK IT0 8 ET0 9 PTO 10 10 TO 11 11 TO 12 ________________________________~ ANIMAL 69354 13. 13. 14. 14. 13. 69366 12. 11. 12. 12. 12. 69367 14. 13. 13. 13. 14. 69378 13. 12. 13. 14. 14. 69384 12. 12. 12. 12. 12. 69398 12. 13. 13. 13. 12. 69404 13. 13. 13. 13. 12. PAGE 13 0 PPM 12 TO 13 __________________~~~~~

13. SCHEDULED EUTH WEEK 13 13. SCHEDULED EUTH WEEK 13 13. SCHEDULED EUTH WEEK 13 14. SCHEDULED EUTH WEEK 13 13. SCHEDULED EUTH WEEK 13 13. SCHEDULED EUTH WEEK 13 13. SCHEDULED EUTH WEEK 13 14. SCHEDULED EUTH WEEK 13 14. SCHEDULED EUTH WEEK 13 16. SCHEDULED EUTH WEEK 13 69416 14. 14. 13. 14. 14. 69419 13. 14. 14. 13. 14. 69432 12. 13. 13. 4. 11.

MEAN 13. 13. 13. 12. 13. 14. S. D. 0.8 0.9 0.7 3.0 1.1 1.0 N 10 10 10 10 10 10 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE WEEK 7T0 8 ______________ ANIMAL 69362 13. 69376 11. 69382 13. 69390 13. 69393 11. 69396 12. 69409 12. 69413 12. 69435 13.

MEAN 12. S. D. 0.8 N 9 8TO 9 _________

13. 13. 13. 13. 11. 13. 12. 13. 13.

13. 0.7 9 TABLE 23 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY] PAGE 14 FEMALE GROUP: 15 PPM 9TO 10 10 TO 11 11 TO 12 12 TO 13 ________________________________________

13. 13. 12. 11. 13. 13. 13. 13. 11. 11. 13. 12. 13. 12. 13. 13. 13. 13.

13. 12. 0.7 0.9 9 9 13. 11. 13. 13. 11. 12. 12. 13. 13.

12. 0.9 9 14. 12. 13. 13. 12. 12. 12. 12. 12.

12. 0.7 9 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 SCHEDULED EUTH WEEK 13 TABLE 23 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY]

WEEK _____ __ ANIMAL 69359 69369 69370 69380 69388 69394 69426 69428 69433 69436 7T0 8 ET0 9 _____________________

11. 11. 12. 13. 13. 13. 13. 14. 12. 13. 12. 12. 14. 14. 11. 12. 12. 12. 13. 12. 9TO 10 12. 13. 13. 14. 13. 12. 14. 12. 12. 13. FEMALE GROUP: 40 PPM 10 TO 11 11 TO 12 12 TO 13 ____________________ .___________

12. 11. 13. 13. 12. 12. 14. 13. 13. 12. 12. 12. 14. 13. 11. 12. 13. 12. 14. 14. 11. SCHEDULED EUTH WEEK 13 13. SCHEDULED EUTH WEEK 13 12. SCHEDULED EUTH WEEK 13 14. SCHEDULED EUTH WEEK 13 14. SCHEDULED EUTH WEEK 13 12. SCHEDULED EUTH WEEK 13 14. SCHEDULED EUTH WEEK 13 12. SCHEDULED EUTH WEEK 13 13. SCHEDULED EUTH WEEK 13 13. SCHEDULED EUTH WEEK 13 MEAN 12. 13. 13. 13. 12. 13. S. D. 0.9 1.0 0.8 1.0 0.8 1.0 N 10 10 10 10 10 10 PAGE 15 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 23 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL FOOD CONSUMPTION [G/ ANIMAL/ DAY]

WEEK _ _ _ _ _ _  _ _ ANIMAL 69375 69379 69383 69385 69392 69402 69408 69415 69427 69431 7 TO 11 13 12 13 11 14 12 13 12 14 8 8T0 9 _______

12. 13. 13. 13. 12. 14. 13. 13. 13. 14. YTO 10 11. 12. 12. 13. 12. 13. 13. 12. 12. 13. FEMALE GROUP: 100 PPM 10 TO 11 11 TO 12 12 TO 13 __________________ _ _ _ _ _ _ _ _ _ _ _ _

11. 10. 13. 12. 12. 12. 14. 13. 12. 10. 13. 12. 12. 12. 13. 12. 12. 12. 13. 13. 11. SCHEDULED EUTH WEEK 13 12. SCHEDULED EUTH WEEK 13 12. SCHEDULED EUTH WEEK 13 13. SCHEDULED EUTH WEEK 13 11. SCHEDULED EUTH WEEK 13 14. SCHEDULED EUTH WEEK 13 12. SCHEDULED EUTH WEEK 13 12. SCHEDULED EUTH WEEK 13 13. SCHEDULED EUTH WEEK 13 13. SCHEDULED EUTH WEEK 13 PAGE 16 MEAN 13. 13. 12. 13. 12. 12. S. D. 1.1 0.7 0.7 0.8 1.0 0.9 N 10 10 10 10 10 10 PBFTSv4.23 01/ 18/ 2002 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 24 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL HEMATOLOGY VALUES PAGE 1 WEEK 13 _____________________________________ WHITE RED HEMO HEMATO PLATELET PROTIME APTT ANIMAL CELL CELLS GLOBIN CRIT MCV MCH MCHC ________________________________________

thous/ uL mil/ uL g/ dL 'i; fL uw3 g/ dL thous/ uL seconds seconds _______________ GROUP: 0 PPM MALES 69302 8.2 8 52 15.0 41.7 49.0 17.6 35.9 701. 14.2 26.3 69306 9.9 8 91 15.8 43.6 48.9 17.7 36.3 742. CLT CLT 69308 6.1 9 43 16.2 45.3 48.0 17.1 35.7 762. 13.2 23.3 69310 6.9 8 97 15.6 43.4 48.4 17.3 35.8 1088. 16.5 28.2 69312 5.9 8 11 14.3 39.7 49.0 17.6 36.0 1047. 13.5 26.0 69314 6.2 8 21 14.2 39.2 41.7 17.2 36.1 885. 13.2 19.8 69317 7.7 8 09 14.2 39.0 48.2 17.6 36.5 1236. 13.9 24.5 69322 6.6 8 37 14.6 41.2 49.1 17.5 35.5 1035. 13.1 27.1 69337 6.1 7 71 13.1 37.1 48.1 17.0 35.4 650. 14.3 26.0 69343 9.3 8 06 14.2 40.4 50.1 17.6 35.1 915. 13.0 14.6 MEAN 1.3 8.44 14.7 41.1 48.7 17.4 35.8 906. 13.9 24.0 S. D. 1.43 0.522 0.93 2.49 0.71 0.25 0.42 192.7 1.10 4.29 N 10 10 10 10 10 10 10 10 9 9 CLT = CLOTTED ___________________________________ g/ dL = GRAMS/ DECILITER, thous/ uL = THOUSANDS/ MICROLITER, mil/ uL = MILLIONS/ MICROLITER, uug = PICOGRAMS, fL = FEMTOLITERS PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 24 PO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL HEMATOLOGY VALUES PAGE 2 WEEK 13 ______________________________________ WHITE RED HEMO HEMATO PLATELET PROTIME APTT ANIMAL CELL CELLS GLOBIN CRIT MCV MCH MCHC _____________________________________

thous/ uL mil/ uL g/ dL % fL UP3 ddL thous/ uL seconds seconds _____________________________________ GROUP: 15 PPM MALES 69305 7 0 9.18 16.3 44.4 48.4 17.7 36.7 742. CLT CLT 69316 6 6 9.29 16.2 44.5 47.9 17.4 36.3 686. 13.3 19.7 69320 4 5 8.20 14.4 38.8 47.3 17.5 37.0 985. 15.2 26.4 69323 6 9 8.49 15.2 42.2 49.1 17.9 35.9 1126. 13.5 26.1 69326 8 5 8.51 15.0 41.4 48.6 17.7 36.3 756. 12.7 21.3 69335 7 6 8.24 14.3 39.4 47.8 17.4 36.3 1056. 13.5 29.5 69336 8 9 8.57 15.3 42.2 49.3 17.8 36.2 1103. 13.1 24.7 69338 8 1 8.52 15.0 41.4 48.6 17.6 36.3 682. 14.3 23.2 69345 8 0 8.78 15.4 42.7 48.7 17.5 36.0 1159. 14.0 26.8 69347 6 5 8.62 14.8 41.2 47.8 17.1 35.9 705. CLT CLT MEAN 7.3 8.64 15.2 41.8 48.4 17.6 36.3 900. 13.7 24.7 r 2 S. D. N 1.27 10 0.357 10 0.66 10 1.84 10 0.73 10 0.23 10 0.34 10 202.2 10 0.78 8 3.19 8 g ______________________________________ m CLT = CLOTTED 5, _____________________________________

g/ dL = GRAMS/ DECILITER, thous/ uL = THOUSANDS/ MICROLITER, mil/ uL = MILLIONS/ MICROLITER, uug = PICOGRAMS, fL = FEMTOLITERS PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 24 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL HEMATOLOGY VALUES PAGE 3 WEEK 13 ________________________________________ _  _ _ _ _ _

WHITE RED HEMO HEMATO PLATELET PROTIME APTT ANIMAL CELL CELLS GLOBIN CRIT MCV MCH MCHC ____________________

_____________ r" oUs!~~~~~!~~~!~~~~~~~~~~~~~~~~~!~~~~~~~~~~~~~~~~~ thous/ uL GROUP: 40 PPM MALES 69303 6.9 8 79 15.2 42.2 48.0 17.4 36.2 668. 13.1 21.4 69309 6.5 8 41 14.7 40.9 48.6 17.5 35.9 1139. 16.3 26.6 69313 10.1 9 05 16.1 45.5 50.2 17.8 35.5 555. CLT CLT 69315 5.6 8 90 14.1 38.6 43.4 15.9 36.6 690. 13.2 13.7 69324 6.9 8 14 14.2 39.3 48.3 17.4 36.1 955. 13.4 26.5 69328 8.1 9 05 15.6 44.5 49.2 17.3 35.2 1273. 14.1 26.4 69339 6.3 8 29 14.2 39.3 47.4 17.2 36.2 574. 13.0 18.9 69344 7.7 7 99 13.9 38.9 48.7 17.5 35.8 1084. 13.6 25.8 69348 5.4 8 33 14.4 39.5 47.4 17.2 36.3 705. 14.6 25.5 69350 7.0 8 07 14.1 38.8 48.1 17.5 36.4 1086. 13.5 23.6 MEAN 7.1 8.50 14.7 40.8 47.9 17.3 36.0 873. 13.9 23.2 S. D. 1.36 0.409 0.74 2.50 1.80 0.51 0.43 262.8 1.04 4.43 N 10 10 10 10 10 10 10 10 9 9 ____________________________________ CLT = CLOTTED g/ dL = GRAMS/ DECILITER, thous/ uL = THOUSANDS/ MICROLITER, mil/ uL = MILLIONS/ MICROLITER, uug = PICOGRAMS, fL = FEMTOLITERS PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 24 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL HEMATOLOGY VALUES PAGE 4 WEEK 13 WHITE RED HEMO HEMATO PLATELET PROTIME APTT ANIMAL CELL CELLS GLOBIN CRIT MCV MCH MCHC thous/ uL mil/ uL g/ dL % fL uug g/ a thous/ uL seconds seconds GROUP: 100 PPM MALES 69304 6 3 8.14 14.0 39.5 48.5 17.2 35.6 1070. 12.8 22.6 69307 9 0 9.32 16.4 45.9 49.3 17.6 35.7 538. CLT CLT 69318 5 6 8.32 14.4 40.1 48.2 17.4 36.0 621. CLT CLT 69319 7 4 8.91 15.0 42.6 47.8 16.9 35.4 1246. 13.4 23.5 69327 6 0 8.37 14.8 41.6 49.7 17.7 35.6 1193. 13.7 25.1 69329 8 0 9.34 16.3 45.5 48.7 17.4 35.8 870. 13.3 17.6 69332 5 8 7.98 14.1 38.8 48.6 17.7 36.4 1224. 14.2 26.4 69334 5 6 7.86 14.1 38.3 48.8 17.9 36.8 637. CLT CLT 69342 5 6 8.23 14.4 40.2 48.8 17.5 35.8 999. 13.5 24.3 69346 6 8 9.54 16.3 46.4 48.6 17.1 35.2 887. 14.0 24.7 MEAN 6.6 8.60 15.0 41.9 48.7 17.4 35.8 929. 13.6 23.5 S. D. 1.18 0.620 0.98 3.06 0.53 0.31 0.47 262.5 0.46 2.85 N 10 10 10 10 10 10 10 10 7 7 ____________________________________ CLT = CLOTTED __________________________________ g/ dL = GRAMS/ DECILITER, thous/ uL = THOUSANDS/ MICROLITER, mil/ uL = MILLIONS/ MICROLITER, uug = PICOGRAMS, fL = FEMTOLITERS PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 24 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL HEMATOLOGY VALUES PAGE 5 WEEK 13 ________________________________________ WHITE RED HEMO HEMATO PLATELET PROTIME APTT ANIMAL CELL CELLS GLOBIN CRIT MCV MCH MCHC _______________________________________

___________"" ous!~~~~~!~~~~!~~~~~~~~~!~~~~~~~~~~~~~~~~ thous/ uL GROUP: 0 PPM FEMALES 69354 69366 69367 69378 69384 69398 69404 69416 69419 69432 6.8 5.0 QNS 3.5 6.5 5.4 ;Nz 4.0 5.8 8.19 7.52 QNS 7.45 7.72 7.64 7.53 QNS 7.96 7.19 15.5 14.2 QNS 14.3 14.3 14.5 14.3 QNS 15.0 13.5 43.4 53.0 39.1 52.0 QNS QNS 38.6 51.9 40.1 51.9 39.8 52.1 39.2 52.1 QNS QNS 40.8 51.3 38.0 52.9 18.9 35.7 1338. 13.5 20.3 18.8 36.2 1127. 13.6 17.6 QNS QNS QNS 13.1 18.8 19.2 37.0 973. 14.0 19.4 18.6 35.8 86. CLT CLT 18.9 36.4 715. 13.0 14.1 19.0 36.4 1280. 13.3 16.0 QNS QNS QNS 12.9 17.1 18.8 36.7 745. 13.5 17.0 18.8 35.6 1182. 13.1 20.5 MEAN 5.3 7.65 14.5 39.9 52.2 18.9 36.2 931. 13.3 17.9 S. D. 1.13 0.311 0.59 1.67 0.56 0.18 0.50 411.6 0.35 2.10 N 8 8 8 8 8 8 8 0 9 9 CLT = CLOTTED, QNS = QUANTITY NOT SUFFICIENT ____________

g/ dL = GRAMS/ DECILITER, thous/ uL = THOUSANDS/ MICROLITER, mil/ uL = MILLIONS/ MICROLITER, uug = PICOGRAMS, fL = FEMTOLITERS 180of619 TABLE 24 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 7 SPONSOR: HAP TASK FORCE INDIVIDUAL HEMATOLOGY VALUES WEEK 13 ______________________________________ WHITE RED HEMO HEMATO PLATELET PROTIME APTT ANIMAL CELL CELLS GLOBIN CRIT MCV MCH MCHC _______________________ m13" 11"_______ 9~~ thous/ uL I GROUP: 40 PPM FEMALES 69359 3.6 7.45 14.0 69369 4.5 1.58 14.3 69370 5.5 7.92 14.8 69380 5.2 7.59 14.3 69388 6.5 8.08 14.8 69394 5.1 7.61 14.6 69426 3.5 7.84 14.7 69428 8.0 7.64 14.3 69433 su su su 69436 RU RU RU MEAN 5.2 7.71 14.5 ;;;; S. D. 1.49 0.211 0.29 v N 8 8 8 13, _________________ % fL uw g/ dL thous/ uL seconds seconds 38.1 51.2 18.8 36.6 536. CLT CLT 39.4 52.0 18.8 36.2 1097. 14.1 17.6 41.0 51.8 18.6 36.0 627. CLT CLT 38.9 51.3 18.8 36.6 1098. 13.5 18.1 41.2 51.0 18.3 36.0 729. 12.1 13.9 40.2 52.8 19.2 36.4 1241. 13.5 20.2 40.0 50.9 18.8 36.9 1185. 13.4 16.1 40.4 52.9 18.7 35.4 1131. 13.2 21.3 su su su su su CLT CLT RU RU RU RU RU 14.0 19.7 39.9 51.7 18.8 36.3 956. 13.4 18.1 1.05 0.78 0.25 0.47 277.9 0.66 2.55 8 8 8 8 8 7 I  a CLT = CLOTTED, SU = SAMPLE UNOBTAINABLE, RU = RESULT UNOBTAINABLE _____ __

\o  g/ dL = GRAMS/ DECILITER, thous/ uL = THOUSANDS/ MICROLITER, mil/ uL = MILLIONS/ MICROLITER, uug = PICOGRAMS, fL = FEMTOLITERS PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 24 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL HEMATOLOGY VALUES PAGE 8 WEEK 13 ___________________________________~ WHITE RED HEMO HEMATO PLATELET PROTIME APTT ANIMAL CELL CELLS GLOBIN CRIT MCV MCH MCHC _____________________________________ thous/ uL mil/ uL g/ dL % fL uw g/ dL thous/ uL seconds seconds _______________________________________ GROUP: 100 PPM FEMALES 69375 QNS QNS QNS QNS QNS QNS QNS QNS CLT CLT 69379 5.6 8.32 15.6 44.7 53.7 18.7 34.8 635. CLT CLT 69383 3.9 8.29 15.6 43.6 52.6 18.8 35.8 1313. 13.4 19.6 69385 3.3 7.26 13.7 37.8 52.1 18.8 36.1 1087. 13.8 20.2 69392 5.3 7.63 14.3 40.0 52.5 18.8 35.8 1236. 13.8 20.5 69402 5.8 8.20 15.2 42.2 51.5 18.6 36.1 1295. 11.0 20.2 69408 4.3 7.77 14.4 40.3 51.8 18.6 35.9 1207. 13.9 18.6 69415 6.3 7.37 13.8 39.6 53.8 18.8 34.9 751. 13.9 17.8 69427 4.5 7.90 15.0 41.6 52.6 19.0 36.2 744. 13.8 16.2 69431 3.6 8.12 15.1 41.7 51.3 18.6 36.1 731. 14.5 24.2 MEAN 4.7 7.87 14.7 41.3 52.4 18.7 35.7 1000. 13.5 19.7 S. D. 1.06 0.394 0.72 2.11 0.88 0.13 0.53 279.3 1.06 2.34 N 9 9 9 9 9 9 9 9 8 8 CLT = CLOTTED, QNS = QUANTITY NOT SUFFICIENT g/ dL = GRAMS/ DECILITER, thous/ uL = THOUSANDS/ MICROLITER, mil/ uL = MILLIONS/ MICROLITER, uug = PICOGRAMS, fL = FEMTOLITERS PHEMv4.0 01/ 18/ 2002 183 of 619 TABLE 25 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 2 SPONSOR: HAP TASK FORCE INDIVIDUAL LEUKOCYTE DIFFERENTIAL COUNTS [% I WEEK 13 NEUTRO LYMPH EOSIN ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL ________ ________________________________________ GROUP: 15 PPM MALES 69305 14 85 0 1 0 69316 14 84 2 0 0 69320 21 75 4 0 0 69323 17 78 5 0 0 69326 14 83 3 0 0 69335 22 77 1 0 0 69336 17 79 4 0 0 69338 14 83 3 0 0 69345 17 83 0 0 0 69347 21 79 0 0 0 MEAN 17 81 2 0 0 S. D. 3.2 3.4 1.9 0.3 0.0 _"____ '"______ '"_______ '"_______ '~~~~~~~~~~ TABLE 25 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 3 SPONSOR: HAP TASK FORCE INDIVIDUAL LEUKOCYTE DIFFERENTIAL COUNTS [% I WEEK 13 ANIMAL GROUP: 40 PPM 69303 14 82 4 69309 18 78 4 69313 16 78 5 69315 19 81 0 69324 19 77 4 69328 20 73 7 69339 19 79 2 69344 24 72 4 69348 18 76 6 69350 16 83 1 MEAN 18 S. D. 2.7 NEUTRO PHIL N 10 LYMPH OCYTE MONOCYTE ________________ MALES 78 4 3.6 2.2 10 10 __ EOSIN OPHIL BASOPHIL ________________________________________

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.3 0.0 10 10 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 25 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL LEUKOCYTE DIFFERENTIAL COUNTS [% I PAGE 4 WEEK 13 NEUTRO LYMPH EOSIN ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL ______________________________________~~~~ GROUP: 100 PPM MALES 69304 25 70 5 0 0 69307 14 82 4 0 0 69318 23 76 1 0 0 69319 15 79 5 1 0 69327 17 79 4 0 0 69329 18 82 0 0 0 69332 16 81 3 0 0 69334 19 78 3 0 0 69342 24 72 4 0 0 69346 18 76 5 1 0 MEAN 19 78 3 0 0 S. D. 3.8 4.1 1.7 0.4 0.0 __ '"_________ '"_______ '"_______ '"______~~~~~~ PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 25 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL LEUKOCYTE DIFFERENTIAL COUNTS [%] PAGE 5 WEEK 13 __________________ NEUTRO LYMPH EOSIN ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL _______________________________________ GROUP: 0 PPM FEMALES 69354 69366 69367 69378 69384 69398 69404 69416 69419 69432 20 80 0 16 QUANTIT? NOT SUFFkIENT 16 80 3 14 85 1 14 85 1 19 QUANTIT; SNOT SUFFZCIENT 14 85 1 23 73 4 0 0 MEAN 17 81 2 0 0 S. D. 3.3 4.2 1.4 0.4 0.0 N 8 8 8 8 8 ___________________________________ PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 25 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL LEUKOCYTE DIFFERENTIAL COUNTS [% I PAGE 6 WEEK 13 NEUTRO LYMPH EOSIN ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL GROUP: 15 PPM FEMALES 69362 69376 69382 69390 69393 69396 69409 69413 69435 15 85 15 83 16 81 12 86 13 86 22 Q~ ANTIT;~ NOT 15 80 10 90 0 2 3 2 1 4 SUFFICIENT 5 0 MEAN 15 83 2 0 0 S. D. 3.5 4.9 1.8 0.0 0.0 N 8 8 8 8 8 ______________________________________ TABLE 25 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 7 SPONSOR: HAP TASK FORCE INDIVIDUAL LEUKOCYTE DIFFERENTIAL COUNTS [% I WEEK 13 ________________________________________

ANIMAL _____

GROUP:

69359 69369 69370 69380 69388 69394 69426 69428 NEUTRO PHIL _ _ _ _ _ _ _ _

40 PPM 10 16 17 13 14 15 23 14 LYMPH EOSIN OCYTE MONOCYTE OPHIL BASOPHIL ____________________________________

FEMALES 88 2 0 0 81 3 0 0 81 2 0 0 84 3 0 0 81 5 0 0 79 6 0 0 72 5 0 0 85 1 0 0 69433 SAMPLE UNOBTAINABLE 69436 RESULT UNOBTAINABLE MEAN 15 81 3 0 0 S. D. 3.8 4.7 1.8 0.0 0.0 N CI 8 8 8 8 8 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 25 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL LEUKOCYTE DIFFERENTIAL COUNTS [% I PAGE 8 WEEK 13 _____________________________________~~~ NEUTRO LYMPH EOSIN ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL GROUP:

69375 69379 69383 69385 69392 69402 69408 69415 69427 69431 MEAN S. D. N 100 PPM FEMALES QUANTITY NOT SUFFICIENT 13 17 15 17 19 15 11 16 16 15 2.4 9 84 80 83 78 76 81 89 81 80 81 3.7 9 _________ 2 3 2 4 5 4 0 3 4 3 1.5 9 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0.4 0.0 9 9 ____________________________________ ______________________________________ PDIFFv4.1 01/ 18/ 2002 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 26 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL LEUKOCYTE COUNTS PAGE 1 WEEK 13 0 PPM MALE ______________________________________ TOTAL NEUTRO LYMPH EOSIN LEUKOCYTES PHIL OCYTE MONOCYTE OPHIL BASOPHIL ANIMAL thous/ uL thous/ uL thous/ uL thous/ uL thous/ uL thous/ uL ________________________________________

69302 8.2 1.4 6.5 0.3 0.0 0.0 69306 9.9 1.5 8.4 0.0 0.0 0.0 69308 6.1 1.0 4.9 0.1 0.0 0.0 69310 6.9 1.3 5.2 0.3 0.1 0.0 69312 5.9 1.2 4.4 0.2 0.0 0.0 69314 6.2 1.5 4.7 0.1 0.0 0.0 69317 7.7 1.6 5.8 0.3 0.0 0.0 69322 6.6 1.3 5.1 0.2 0.0 0.0 69337 6.1 1.2 4.9 0.0 0.0 0.0 69343 9.3 1.6 7.7 0.0 0.0 0.0 MEAN 7.3 1.4 5.8 0.2 0.0 0.0 S. D. 1.43 0.19 1.36 0.14 0.02 0.00 N 10 10 10 10 10 10 5; ______________________________________ w thous/ uL = THOUSANDS/ MICROLITER % o\

G TABLE 26 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE PAGE 2 INDIVIDUAL LEUKOCYTE COUNTS WEEK 13 15 PPM MALE TOTAL NEUTRO LYMPH EOSIN LEUKOCYTES PHIL OCYTE MONOCYTE ANIMAL OPHIL thous/ uL thous/ uL BASOPHIL thous/ uL thous/ uL thous/ uL thous/ uL 69305 7.0 1.0 6.0 0.0 0.1 69316 6.6 0.9 0.0 5.5 0.1 0.0 69320 4.5 0.9 0.0 3.4 0.2 0.0 69323 6.9 1.2 0.0 5.4 0.3 0.0 69326 8.5 1.2 0.0 7.1 0.3 69335 7.6 0.0 1.7 0.0 5.9 0.1 0.0 69336 8.9 1.5 0.0 7.0 0.4 0.0 69338 8.1 1.1 0.0 6.7 0.2 0.0 69345 8.0 1.4 0.0 6.6 0.0 0.0 69347 6.5 1.4 0.0 5.1 0.0 0.0 0.0 __________________ MEAN 7.3 1.2 5.9 0.2 S. D. 1.27 0.0 0.0 0.25 N 1.12 0.14 10 0.02 0.00 10 10 10 10 10 ______________________________________~~~~~ thous/ uL = THOUSANDS/ MICROLITER % a s 193of619 TABLE 26 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE PAGE 4 INDIVIDUAL LEUKOCYTE COUNTS WEEK 13 100 PPM MALE __________

TOTAL NEUTRO LYMPH LEUKOCYTES PHIL EOSIN OCYTE ANIMAL thous/ uL MONOCYTE OPHIL thous/ uL thous/ uL BASOPHIL thous/ uL thous/ uL thous/ uL _____________ 69304 6.3 1.6 4.4 69307 9.0 0.3 1.3 0.0 7.4 0.0 69318 5.6 0.4 1.3 0.0 4.3 0.0 69319 7.4 0.1 1.1 0.0 5.8 0.0 69327 6.0 0.4 1.0 0.1 4.7 0.0 69329 8.0 0.2 1.4 0.0 6.6 0.0 69332 5.8 0.0 0.9 0.0 4.7 0.0 69334 5.6 0.2 1.1 0.0 4.4 0.0 69342 5.6 0.2 1.3 0.0 4.0 0.0 69346 6.8 0.2 1.2 0.0 5.2 0.0 0.3 0.1 0.0 ______________________________________~~ MEAN 6.6 1.2 5.1 S. D. 0.2 1.18 0.0 0.20 1.11 0.0 N 0.13 10 0.03 10 0.00 10 10 10 10 g ____________________________________

thous/ uL = THOUSANDS/ MICROLITER 0 Lt z 195 of 619 TABLE 26 PROJECT NO.: WIL 417002 PO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE PAGE 6 INDIVIDUAL LEUKOCYTE COUNTS WEEK 13 15 PPM FEMALE ______________________________________ TOTAL NEUTRO LYMPH LEUKOCYTES EOSIN PHIL OCYTE MONOCYTE ANIMAL thous/ uL OPHIL thous/ uL thous/ uL BASOPHIL thous/ uL thous/ uL thous/ uL 69362 5.7 0.9 4.8 0.0 69376 9.0 1.4 0.0 7.5 0.0 0.2 69382 5.7 0.9 0.0 4.6 0.0 69390 5.4 0.2 0.6 0.0 4.6 0.0 0.1 69393 5.4 0.7 0.0 4.6 0.0 69396 0.1 1.0 0.0 3.5 0.0 QUkl; ITY NOT SUFFICIENT 0.2 69409 0.0 0.0 69413 4.5 0.7 3.6 0.2 69435 4.7 0.5 0.0 4.2 0.0 0.0 0.0 0.0 _______________________________________ MEAN 5.6 0.8 4.7 S. D. 0.1 1.44 0.0 0.27 0.0 1.23 N 0.09 8 0.00 8 8 0.00 8 8 8 ________________________________________ thous/ uL = THOUSANDS/ MICROLITER ~3LI~ omIW/ safsnoHL = v/ snow ________~

8 8 8 8 8 00'0 8 00'0 N OK. 0 ZE'K ZZ'O 6P'T _ '1:~________________": 0_______________":~__________________ 4:"________~~~~~~~~~~~ 'a's 318VNI'FIL00Nll LTnS3~ YEP69 0'0 0'0 31ffYNIVLLBONn 3TdNVS K. 0 EEf769 8.9 0'0 K'K 0'0 0'8 8ZP69 2'0 S'Z 0'0 8'0 0.0 S'E E'O 92869 O'P 0'0 8'0 0'0 K. S E. 0 P6E69 E'S 0'0 6'0 0'0 S'P 88E69 Z'O P'P 0'0 L'O 0'0 Z'S K'O 08E69 S'P 0'0 6'0 0` 0 S'S T. 0 OLE69 P'E L` O S'P __":"_______________":"_____________~~~~~~~~~~~~~~~~~~~~~~~~~~~ 69E69 m/ snoq3 m/ snoya lnjsnoy? w/ snow m/ snow TIHdOSV8 Tn/ snoy> TIHdO TiWINv 3LA30NOW 3LA30 TIHd NISOS S3~ h~ OXfl31 HdWAT 08Ln3N lb LO6 ________________________________ 31VW3d Wdd OP EK X33M L smnoa 3Lh3oxn37 wnaImaN1 33Vd 3XOd XSBL dVH: XOSNOdS 331W '9 SLYkl NI Xd HLIM SLV8 NI 3X Z'I'T d0 hCInX 5 'TVHNI hVCI 06 ZOOLKP 'IIM: 'ON LL33POXd 92 318V. L 1980f 619 TABLE 27 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 1 SPONSOR: HAP TASK FORCE INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 13 _________________________________~~~~~~~~ ALBUMIN TOTAL GLOBULIN A/ G TOTAL UREA CREAT ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL PROTEIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER _________________ 9!"~~!~~~!~~~~~!~~~~!~~~~!~~~!~~!~~~!~~!~ GROUP: 0 PPM MALES 69302 4.2 69306 4.6 69308 4.6 69310 4.3 69312 3.9 69314 3.9 69317 3.9 69322 4.3 69337 4.3 69343 4.1 7 I 4 3 2 1.31 0.2 13.8 0.2 85 106. 174. 0. 3 3 7 1.24 0.3 17.2 0.3 110 105. 144. 0. 0 3 4 1.35 0.4 19.3 0.3 96 86. 114. 0. 1 2 8 1.54 0.1 13.8 0.2 106 64. 106. 0. 4 2 5 1.56 0.1 15.3 0.0 76 51. 68. 0. 6 2 7 1.44 0.1 16.6 0.3 85 62. 85. 0. 8 2 9 1.34 0.1 17.3 0.2 68 63. 102. 0. 3 3 0 1.43 0.1 15.6 0.3 94 55. 84. 0. 4 3 1 1.39 0.1 18.9 0.2 101 51. 83. 0. 6 3 5 1.17 0.2 17.2 0.3 112 56. 100. 0.

MEAN 4.2 7.3 3.1 1.38 0.2 16.5 0.2 93. 70. 106. 0. S. D. 0.26 0.60 0.38 0.123 0.11 1.89 0.09 14.7 21.3 31.8 0.0 ______" 1'_________""________ 4"________~~~~~~~~~~~~~~~~~~~~~~~ U/ L = INTERNATIONAL UNIT/ LITER, g/ dL = GRAMS/ DECILITER, mg/ dL = MILLIGRAMS/ DECILITER TABLE 27 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 2 SPONSOR: HAP TASK FORCE INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 13 __________________

GLUCOSE CHOL CALCIUM CHLORIDE PHOS POTAS SODIUM TRIGLY ANIMAL ESTEROL PHORUS SIUM CERIDE _______________________________________

_______________ m4!"~~~~!~~~~~!~~~~~!~~~~~!~~~~~~ mg/ dL mEq/ L mEq/ L GROUP: 0 PPM MALES 69302 181. 52. 11 8 100. 11.8 5 59 150 70. 69306 143. 56. 12 3 98. 14.0 5 81 153 142. 69308 126. 50. 11 7 101. 12.8 7 68 149 116. 69310 165. 43. 11 3 102. 9.8 5 89 151 78. 69312 144. 54. 10 a 102. 9.0 4 15 148 51. 69314 161. 46. 10 8 102. 8.4 4 66 148 58. 69317 136. 58. 11 0 102. 9.3 5 53 147 100. 69322 152. 53. 11 1 103. 8.7 5 63 148 38. 63337 163. 53. 11 I 101. 11.5 5 74 149 84. 69343 146. 61. 11 5 100. 10.3 5 72 148 80.

g MEAN S. D. 152. 16.1 53. 5.3 11.5 0.51 101. 1.4 10.6 5.64 149. 1.89 0.911 1.8 27.3 88.

0 % ______"__________ 1"________""________ '"~~~~~~~~~~~~ mg/ dL = MILLIGRAMS/ DECILITER, mEq/ L = milliEquivalents/ Liter 0 J s TABLE 27 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 3 SPONSOR: HAP TASK FORCE INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 13 ________

ALBUMIN TOTAL GLOBULIN A/ G TOTAL UREA CREAT ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL PROTEIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER _____________________________________

mg/ dL mg/ dL mg/ dL U/ L U/ L U/ L U/ L GROUP: 15 PPM MALES 69305 69316 69320 69323 69326 69335 69336 69338 69345 69347 g MEAN S. D.

;; N ________

2 s 4.8 8.2 3.4 41 4.6 8.1 3.5 31 4.0 6.6 2.6 54 4.3 1.3 3.0 43 4.2 7.3 3.1 35 4.1 7.1 3.0 37 4.1 7.0 2.9 1 41 4.3 7.5 3.2 1 34 4.1 7.2 3.1 1 32 4.2 7.5 3.3 1 21 4.3 7.4 3.1 1.38 0.25 0.48 0.26 0.077 10 10 10 10 .____________________________________ U/ L = INTERNATIONAL UNIT/ LITER, g/ dL 0.2 14.6 0.4 17.2 0.1 14.1 0.1 15.7 0.2 17.5 0.1 17.5 0.1 16.6 0.2 17.3 0.1 15.9 0.1 17.2 0.2 16.4 0.10 1.24 10 10 __________ = GRAMS/ DECILITER, 0. 0. 0. 0. 0. 0. 0. 0. 0. 0. 2 114. 3 98. 2 86. 3 95. 2 91. 2 89. 3 92. 3 94. 2 84. 2 95. 75. 109. 66. 98. 74. 98. 89. 136. 78. 118. 55. 80. 74. 96. 58. 86. 62. 86. 71. 110.

0.2 94. 70. 0.05 8.3 10.2 10 10 10 .__________________________

mg/ dL = MILLIGRAMS/ DECILITER 102. 17.0 10 __ PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 27 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL SERUM CHEMISTRY VALUES PAGE 4 WEEK 13 ________________________________________ GLUCOSE CHOL CALCIUM CHLORIDE PHOS POTAS SODIUM TRIGLY ANIMAL ESTEROL PHORUS SIUM CERIDE ________________________________________

________________ m~!~~~~~~~~!~~~~~!~~~~~~~!~~~~!~~~~~~!~~~~!~~~~!~~

GROUP: 15 PPM MALES 69305 69316 69320 69323 69326 69335 69336 69338 69345 69347 148. 170. 124. 176. 132. 154. 167. 131. 176. 128. 51. 70. 51. 63. 58. 52. 59. 49. 67. 57. 12 12 11 11 11 11 11 11 11 11 9 100. 14.5 6 48 155 101 0 100. 12.6 6 46 149 179 0 101. 8.4 5 22 148 74 5 100. 8.2 5 38 148 104 0 99. 9.3 4 27 146 107 7 101. 10.5 5 62 148 84 5 98. 9.5 6 01 146 135 4 98. 10.5 4 81 149 60 8 100. 9.8 5 97 148 49 6 100. 11.4 6 09 147 52 MEAN 151. 58. 11.6 100. 10.5 5.63 148. 95. S. D. 20.8 7.2 0.54 1.1 1.94 0.718 2.5 40.4 _____"_________ '"________ '"________ '"~~~~~~~~~~~~~~~~~~~~ mg/ dL = MILLIGRAMS/ DECILITER, mEq/ L = milliEquivalents/ Liter PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 5 SPONSOR: HAP TASK FORCE INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 13 TABLE 27 ALBUMIN TOTAL GLOBULIN A/ G TOTAL UREA CREAT ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL PROTEIN RATIO BILI NITROGEN ININE PHOS` TSE TRANSFER TRANSFER TRANSFER _____________________________________

g/ dL LT/ dL ddL mg/ dL mg/ dL mg/ dL U/ L U/ L U/ L U/ L ________________________________________

GROUP: 40 PPM MALES 69303 4.4 7.5 3.1 1.42 0 2 69309 4.2 7.0 2.8 1.50 0 1 69313 4.3 7.9 3.6 1.19 0 3 69315 4.4 7.6 3.2 1.38 0 1 69324 4.1 6.9 2.8 1.46 0 1 69328 4.0 6.9 2.9 1.38 0 1 69339 4.6 7.7 3.1 1.48 0 2 69344 3.8 6.6 2.8 1.36 0 1 69348 4.4 7.6 3.2 1.38 0 1 69350 3.8 6.4 2.6 1.46 0 1 MEAN S. D. N 4.2 7.2 3.0 0.27 0.51 0.29 10 10 10 U/ L = INTERNATIONAL UNIT/ LITER, 1.40 0.1 15.8 0.2 92. 79. 0.089 0.07 1.62 0.09 9.9 35.7 10 10 10 10 10 10 ________________________ _______________________________ g/ dL = GRAMS/ DECILITER, mg/ dL = MILLIGRAMS/ DECILITER ._ 13 15 15 14 18 14 18 16 14 16 6 :3 0.2 0.2 7 :6 0.3 0.2 .4 0.3 5 :3 0.0 0.3 .6 0.2 7 :6 0.2 0.1 97. 63 107. 88. 70 97. 87. 163 347. 97. 64 83. 98. 59 86. 82. 62 85. 113. 98 170. 81. 54 78. 94. 111 128. 83. 45 66.

125. 83.7 10 _______ 0. 0. 0. 0. 0. 0. 0. 0. 0. 0.

0. 0.0 10 ____________ TABLE 27 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 6 SPONSOR: HAP TASK FORCE INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 13 _______________________________________ GLUCOSE CHOL CALCIUM CHLORIDE PHOS POTAS SODIUM TRIGLY ANIMAL ESTEROL PHORUS SIUM CERIDE __________ m~!"~~~~!~~~~~!~~~~~!~~~!~~~~~!~~~~!~~~!~~~~~~~~~ GROUP: 40 PPM MALES 69303 179. 54. 12.2 99 12.6 6 29 148 69 69309 142. 53. 11.5 99 10.3 5 55 148 53 69313 153. 67. 12.2 98 13.9 5 58 150 94 69315 148. 54. 11.9 98 12.5 7 39 148 62 69324 152. 57. 11.2 101 9.1 5 21 148 100 69328 144. 57. 11.7 100 10.9 6 27 148 34 69339 134. 48. 11.9 100 13.3 5 97 151 79 69344 150. 54. 11.4 99 10.5 5 28 147 47 69348 193. 55. 11.8 100 12.5 8 61 146 61 69350 141. 46. 11.0 103 9.9 5 26 148 36 MEAN 154. 55. 11.7 100. 11.6 6.14 148. 64. S. D. 18.3 5.6 0.40 1.5 1.61 1.094 1.4 22.5 f% ______"__________""________ '"________""~~~~~~~~~~~~ mg/ dL = MILLIGRAMS/ DECILITER, ch mEq/ L = milliEquivalents/ Liter ;; TABLE 27 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS Ez MICE PAGE 7 SPONSOR: HAP TASK FORCE INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 13 ALBUMIN TOTAL GLOBULIN A/ G TOTAL UREA CREAT ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL PROTEIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER g/ dL g/ dL g/ dL mg/ dL mg/ dL w/ dL U/ L U/ L U/ L U/ L GROUP: 100 PPM MALES 69304 4.1 69307 4.6 69318 4.2 69319 4.3 69327 3.9 69329 4.6 69332 3.7 69334 4.4 69342 4.2 69346 4.7 7.0 8.0 7.3 7.1 6.5 7.9 6.2 7.6 7.0 8.2 2.9 1.41 0.1 15.2 3.4 1.35 0.3 14.4 3.1 1.35 0.1 13.9 2.8 1.54 0.1 13.5 2.6 1.50 0.1 14.5 3.3 1.39 0.1 14.7 2.5 1.48 0.1 14.2 3.2 1.38 0.2 17.9 2.8 1.50 0.1 15.2 3.5 1.34 0.4 15.3 kz MEAN 4.3 7.3 3.0 S. D. 0.32 0.65 0.34 ti N 10 10 10 % ______________________________ _________ U/ L = INTERNATIONAL UNIT/ LITER, 6\ 1.42 0.074 10 g/ dL 0.2 14.9 0.11 1.21 10 10 = GRAMS/ DECILITER, . 0. 0. 0. 0. 0. 0. 0. 0. 0. 0. 2 95. 101. 116. 3 103. 102. 213. 2 84. 56. 75. 2 93. 57. 88. 2 91. 56. 85. 3 96. 94. 167. 1 79. 46. 69. 2 100. 79. 110. 2 92. 96. 118. 2 109. 115. 136.

0.2 94. 80. 0.06 8.7 24.6 10 10 10 mg/ dL = MILLIGRAMS/ DECILITER 0. 0. 0. 0. 0. 0. 0. 0. 0. 0.

118. 0. 44.8 0.0 10 10 ____________ TABLE 27 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 8 SPONSOR: HAP TASK FORCE INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 13 _____________________________________

GLUCOSE CHOL CALCIUM CHLORIDE PHOS POTAS SODIUM TRIGLY ANIMAL ESTEROL PHORUS SIUM CERIDE ________________________________________

GROUP: 100 PPM MALES 69304 126 59. 11 7 100. 11 4 5.75 148. 45. 69307 166 66. 12 6 98. 14 6 6.12 152. 105. 69318 125 65. 11 7 99. 12 0 5.85 147. 78. 69319 138 67. 11 7 99. 10 2 5.52 148. 34. 69327 136 64. 10 9 101. 9 7 4.56 147. 81. 69329 168 58. 12 8 97. 13 1 7.22 150. 67. 69332 133 59. 10 8 102. 9 9 5.10 147. 37. 69334 173 66. 12 5 100. 14 9 8.45 150. 67. 69342 138 66. 11 4 102. 9 8 5.04 148. 64. 69346 157 63. 12 3 101. 14 4 8.30 150. 65.

!s MEAN 146. 63. 11.8 100. 12.0 6.19 149. S. D. 18.2 3.4 0.70 1.7 2.12 1.356 1.7 m N 10 10 10 10 10 10 10 % ___________________________________ mg/ dL = MILLIGRAMS/ DECILITER, mEq/ L = milliEquivalents/ Liter ch s 64. 21.5 10 TABLE 21 PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 9 SPONSOR: HAP TASK FORCE INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 13 ALBUMIN TOTAL GLOBULIN A/ G TOTAL UREA CREAT ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL PROTEIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER ___________________________________~~

g/ dL g/ dL g/ dL W/ dL mg/ dL w/ a U/ L U/ L U/ L U/ L ___________________________________~~~~ GROUP: 0 PPM FEMALES 69354 4.0 7.2 69366 3.9 6.5 69367 4.1 QNS 69378 3.8 6.3 69384 3.8 6.7 69398 3.9 6.5 69404 3.8 6.4 69416 su su 69419 4.3 7.2 69432 3.8 6.4 3.2 ;iG 2.5 2.9 2.6 2.6 su 2.9 2.6 1.25 0.1 15.2 0.1 80. 40. 81. 1.50 0.1 15.3 0.2 58. 67. 117. QNS QNS QNS QNS 50. 98. 296. 1.52 0.1 19.2 0.2 67. 43. 73. 1.31 0.3 18.2 0.2 60. 82. 163. 1.50 0.3 13.5 0.2 69. 46. 252. 1.46 0.2 13.9 0.2 57. 39. 75. su su su su su su SU 1.48 0.3 20.5 0.2 53. 63. 117. 1.46 0.1 13.4 0.1 87. 37. 72. 1. 0. 0. 0. 1. 0. 0. su 0. 0.

MEAN 3.9 6.7 2.7 1.44 0.2 16.2 0.2 65. 57. 138. 0. S. D. 0.17 0.36 0.24 0.099 0.10 2.77 0.05 12.4 21.7 83.1 0.4 N 9 8 8 8 8 8 8 9 9 9 9 K ________________________________________ z QNS = QUANTITY NOT SUFFICIENT, SU = SAMPLE UNOBTAINABLE \o ________________________________________ U/ L = INTERNATIONAL UNIT/ LITER, g/ dL = GRAMS/ DECILITER, mg/ dL = MILLIGRAMS/ DECILITER TABLE 27 PROJECT NO.: WIL 417002 YO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 10 SPONSOR: HAP TASK FORCE INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 13 _________________________________~~

GLUCOSE CHOL CALCIUM CHLORIDE PHOS POTAS SODIUM TRIGLY ANIMAL ESTEROL PHORUS SIUM CERIDE _________________________________

GROUP: 0 PPM FEMALES 69354 69366 69367 69378 69384 69398 69404 69416 69419 69432 140. 136. 107. 122. 115. 124. 125. su 146. 102. 80. 11.8 101. 70. 10.9 104. QNS QNS QNS 74. 10.4 105. 76. 10.8 103. 73. 10.6 104. 64. 10.8 102. su su su 85. 11.4 103. 66. 11.5 103. 10.9 ;,: 8.3 10.6 9.4 8.9 su 10.8 10.7 7.06 147. 41. 5.82 146. 24. QNS QNS 45. 4.79 148. 31. 4.98 146. 24. 5.25 146. 34. 5.38 146. 27. su su su 5.94 146. 30. 6.18 148. 26.

MEAN 124. 74. 11.0 103. 9.7 5.68 147. 31. S. D. 14.8 7.0 0.49 1.2 1.28 0.737 0.9 7.4 N 9 8 8 8 8 8 8 9 _____________________________________~ QNS = QUANTITY NOT SUFFICIENT, SU = SAMPLE UNOBTAINABLE ______________________________________

mg/ dL = MILLIGRAMS/ DECILITER, mEq/ L = milliEquivalents/ Liter PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 27 YO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL SERUM CHEMISTRY VALUES PAGE 11 WEEK 13 ________________________________________~~~~ ALBUMIN TOTAL GLOBULIN A/ G TOTAL UREA CREAT ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL PROTEIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER ________________________________________~~

________________ 9!"~~!~~~!~~~~!~~~~~~~!~~~~~~~~!~~~~~~~~~~ W/ dL V/ dL U/ L U/ L GROUP: 15 PPM FEMALES 69362 3.4 5.7 69376 4.0 6.6 69382 4.0 6.7 69390 3.1 6.0 69393 4.1 7.1 69396 3.9 6.7 69409 4.2 7.0 69413 3.9 6.6 69435 4.3 7.2 2 2 3 1.48 6 1.54 7 1.48 3 1.61 0 1.37 8 1.39 8 1.50 7 1.44 9 1.48 2 16 3 16 1 16 1 17 2 17 2 16 4 17 1 17 2 15 0.2 65. 44. 75 0.3 79. 60. 159 0.1 71. 52. 89 0.1 59. 46. 79 0.1 69. 48. 83 0.2 62. 61. 199 0.2 72. 51. 148 0.1 70. 41. 74 0.2 62. 48. 92 MEAN 3.9 6.6 2.7 1.48 0.2 17.0 0.2 68. 50. 111. 0.

g 0.24 S. D. N 0.27 9 0.49 9 9 0.073 9 0.10 9 0.72 9 0.07 9 6.2 9 6.8 9 45.7 9 0.5 9 \o

0, U/ L = INTERNATIONAL UNIT/ LITER, g/ dL = GRAMS/ DECILITER, mg/ dL = MILLIGRAMS/ DECILITER m 6 I . . . . . . . . .

210 of 619 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 27 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL SERUM CHEMISTRY VALUES PAGE 13 WEEK 13 __________________ ALBUMIN TOTAL GLOBULIN A/ G TOTAL UREA CREAT ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL PROTEIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER _______________________________________

GROUP: 40 PPM FEMALES 69359 4.3 7.3 3.0 1.43 0.3 19.8 69369 3.8 6.3 2.5 1.52 0.1 15.4 69370 4.1 7.1 3.0 1.37 0.7 18.1 69380 3.7 6.4 2.7 1.37 0.1 16.8 69388 4.4 7.6 3.2 1.38 0.2 19.2 69394 4.0 6.6 2.6 1.54 0.1 16.6 69426 4.2 7.3 3.1 1.35 0.1 17.7 69428 4.0 6.9 2.9 1.38 0.1 17.5 69433 su su su su su su 69436 4.2 7.2 3.0 1.40 0.1 16.2 MEAN 4.1 7.0 2.9 1.42 0.2 17.5 S. D. 0.23 0.45 0.24 0.069 0.20 1.41 N 9 9 9 9 9 9 0.3 0.1 0.3 0.2 0.2 0.2 0.2 0.2 su 0.3 0.2 0.07 9 U/ L U/ L U/ L U/ L _________________________________~

68. 73. 122. 0. 69. 35. 71. 0. 62. 56. 109. 0. 61. 42. 71. 0. 63. 65. 112. 0. 76. 49. 85. 0. 69. 52. 86. 0. 84. 55. 90. 1. su su su su 75. 65. 93. 2.

70. 55. 93. 0. 7.5 11.9 17.8 0.7 9 9 9 9 _______________________________ SU = SAMPLE UNOBTAINABLE _______________ U/ L = INTERNATIONAL UNIT/ LITER, g/ dL = GRAMS/ DECILITER, mg/ dL = MILLIGRAMS/ DECILITER PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 27 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL SERUM CHEMISTRY VALUES PAGE 14 WEEK 13 __________________________________~ GLUCOSE CHOL CALCIUM CHLORIDE PHOS POTAS SODIUM TRIGLY ANIMAL ESTEROL PHORUS SIUM CERIDE ______________________________________

KJ/ dL mg/ dL W/ dL mEq/ L W/ dL mEq/ L mEq/ L w/ dL GROUP: 40 PPM FEMALES 69359 69369 69370 69380 69388 69394 69426 69428 69433 69436 101. 116. 142. 125. 98. 110. 108. 107. su 135. 86. 68. 84. 85. 99. 88. 93. 78. su 83. 11.7 10.6 11.3 10.8 12.0 11.4 11.2 11.3 su 12.0 102. 105. 106. 103. 100. 102. 104. 103. su 103. 13.4 9.3 13.3 9.0 12.9 9.5 8.9 10.8 su 11.6 7.07 5.21 7.62 4.92 7.20 5.77 5.99 6.17 su 7.39 149. 149. 148. 146. 147. 148. 149. 147. su 148. 31. 25. 39. 24. 31. 21. 27. 22. su 37.

MEAN 116. 85. 11.4 103. 11.0 6.37 148. 29. S. D. 15.2 8.8 0.48 1.8 1.89 0.986 1.1 6.4 N 9 9 9 9 9 9 9 9 ______________________________________ SU = SAMPLE UNOBTAINABLE ______________________________________~~~~~~~ mg/ dL = MILLIGRAMS/ DECILITER,  mEq/ L = milliEquivalents/ Liter PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 27 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL SERUM CHEMISTRY VALUES PAGE 15 WEEK 13 ALBUMIN TOTAL GLOBULIN A/ G TOTAL UREA CREAT ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL PROTEIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER ____________________________________

ddL sJ/ dL g/ a mg/ dL mg/ dL mg/ dL U/ L U/ L U/ L U/ L __________________________________

GROUP: 100 PPM FEMALES 69375 4.4 69379 4.4 69383 4.3 69385 4.0 69392 3.9 69402 4.2 69408 3.9 69415 4.1 69427 su 69431 4.3 7.9 7.5 7.1 6.4 6.4 7.2 6.4 6.8 su 7.2 3.5 1.26 3.1 1.42 2.8 1.54 2.4 1.67 2.5 1.56 3.0 1.40 2.5 1.56 2.7 1.52 su su 2.9 1.48 0.7 0.4 0.1 0.1 0.1 0.1 0.1 0.2 su 0.2 20.0 0.3 14.2 0.2 15.8 0.2 17.6 0.2 16.4 0.1 16.3 0.2 16.1 0.1 18.4 0.3 su su 17.2 0.3 83. 73. 60. 62. 78. 66. 14. 70. su 75. 70. 293. 51. 119. 45. 83. 43. 74. 40. 81. 50. 82. 50. 85. 49. 127. su SU 47. 84. 0. 0. 0. 0. 0. 0. 1. 0. su 1.

MEAN 4.2 7.0 2.8 1.49 0.2 16.9 0.2 71. 49. 114. 0. S. D. 0.20 0.53 0.35 0.118 0.20 1.67 0.08 7.5 8.5 69.5 0.4 N 9 9 9 9 9 9 9 9 9 9 9 ________________________________________ SU = SAMPLE UNOBTAINABLE ______________________________________ U/ L = INTERNATIONAL UNIT/ LITER, g/ dL = GRAMS/ DECILITER, mg/ dL = MILLIGRAMS/ DECILITER PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 27 PO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL SERUM CHEMISTRY VALUES PAGE 16 WEEK 13 _______________ GLUCOSE CHOL CALCIUM CHLORIDE PHOS POTAS SODIUM TRIGLY ANIMAL ESTEROL PHORUS SIUM CERIDE _______________~~

GROUP: 100 PPM FEMALES 69375 76. 89. 12.0 QNS 13.9 QNS QNS 34. 69379 97. 90. 12.1 101. 14.5 6.42 151. 38. 69383 114. 87. 11.7 101. 10.8 6.20 148. 24. 69385 98. 78. 10.8 104. 9.2 5.22 148. 23. 69392 113. 83. 10.9 102. 10.2 6.33 147. 22. 69402 113. 97. 11.9 99. 11.8 6.25 146. 29. 69408 118. 92. 11.2 99. 10.0 5.81 144. 29. 69415 114. 78. 11.0 102. 11.0 4.31 147. 33. 69427 su su su su su su su ,su 69431 109. 81. 11.3 105. 10.6 6.52 148. 30.

MEAN S. D. N 106. 13.3 9 86. 11.4 102. 11.3 5.88 147. 29. 6.6 0.50 2.1 1.78 0.760 2.0 5.4 9 9 8 9 8 8 9 ______________________________________

QNS = QUANTITY NOT SUFFICIENT, SU = SAMPLE UNOBTAINABLE ______________________________________

mg/ dL = MILLIGRAMS/ DECILITER, mEq/ L = milliEquivalents/ Liter PCHEv4.01 01/ 18/ 2002 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 28 (WEEK 1 PRETEST EVALUATION) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL OPHTHALMIC EXAMINATION FINDINGS PAGE 1 ____________________________________~~~~~~~~~~ EXAMINER: DAW INPUT BY: JLK EXAM l( WEEK 1) ANIMAL NO. DOSE GROUP SEX FINDING GRADE ______________________________________~~~~~~

69302 0 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69306 0 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69308 0 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69310 0 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69312 0 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69314 0 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69317 0 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69322 0 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69337 0 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69343 0 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69305 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69316 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69320 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69323 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69326 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69335 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69336 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69338 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69345 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69347 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69303 40 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69309 40 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69313 40 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69315 40 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 CODE: l SLIGHT, 2 MODERATE, 3 SEVERE, P PRESENT, O. D. RIGHT EYE, O. S. LEFT EYE TABLE 28 (WEEK I PRETEST EVALUATION) PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 2 SPONSOR: HAP TASK FORCE INDIVIDUAL OPHTHALMIC EXAMINATION FINDINGS ____________________________________ EXAMINER: DAW INPUT BY: JLK EXAM l( WEEK 1) ANIMAL NO. DOSE GROUP SEX FINDING GRADE ______________________________________ 69324 40 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69328 40 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69339 40 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69344 40 RPM MALE CORNEAL CRYSTALS  BILATERAL 1 69348 40 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69350 40 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69304 100 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69307 100 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69318 100 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69319 100 PPM MALE CORNEAL CRYSTALS  BILATERAL 1 69327 100 PPM 69329 100 PPM MALE C~ RNEAL CRYSTALS  BILATERAL i MALE CORNEAL CRYSTALS  BILATERAL 1 69332 100 PPM 69334 100 PPM 69342 100 PPM 69346 100 PPM 69354 0 PPM 69366 0 PPM 69367 0 PPM 69378 0 PPM 69384 0 PPM 69398 0 PPM 69404 0 PPM 69416 0 PPM MALE MALE MALE MALE FEMALE FEMALE FEMALE FEMALE FEMALE FEMALE FEMALE FEMALE CORNEAL CRYSTALS CORNEAL CRYSTALS CORNEAL CRYSTALS CORNEAL CRYSTALS CORNEAL CRYSTALS CORNEAL CRYSTALS CORNEAL CRYSTALS CORNEAL CRYSTALS CORNEAL CRYSTALS CORNEAL CRYSTALS CORNEAL CRYSTALS CORNEAL CRYSTALS  BILATERAL  BILATERAL  BILATERAL  BILATERAL  BILATERAL  BILATERAL  BILATERAL  BILATERAL  BILATERAL  BILATERAL  BILATERAL  BILATERAL CODE: l SLIGHT, 2 MODERATE, 3 SEVERE, P PRESENT, O. D. RIGHT EYE, O. S. LEFT EYE TABLE 28 (WEEK 1 PRETEST EVALUATION) PROJECT NO.: WIL 417002 VO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 3 SPONSOR: HAP TASK FORCE INDIVIDUAL OPHTHALMIC EXAMINATION FINDINGS EXAMINER: DAW INPUT BY: JLK ANIMAL NO. DOSE GROUP SEX 69419 0 PPM FEMALE 69432 0 PPM FEMALE 69362 15 PPM FEMALE 69376 15 PPM FEMALE 69377 15 PPM FEMALE 69382 15 PPM FEMALE 69390 15 PPM FEMALE 69393 15 PPM FEMALE 69396 15 PPM FEMALE 69409 15 PPM FEMALE 69413 15 PPM FEMALE 69435 15 PPM FEMALE 69359 40 PPM FEMALE 69369 40 PPM FEMALE 69370 40 PPM FEMALE t9 69380 40 PPM FEMALE 2 69388 69394 40 40 PPM PPM FEMALE FEMALE % 69426 40 PPM FEMALE 69428 40 PPM FEMALE a 69433 40 PPM FEMALE G 69436 40 PPM FEMALE 69375 100 PPM FEMALE 69379 100 PPM FEMALE EXAM l( WEEK 1) FINDING GRADE _____________________________________~ CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CORNEAL CRYSTALS  BILATERAL 1 CODE: l SLIGHT, 2 MODERATE, 3 SEVERE, P PRESENT, O. D. RIGHT EYE, O. S. LEFT EYE TABLE 28 (WEEK 1 PRETEST EVALUATION) PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 4 SPONSOR: HAP TASK FORCE INDIVIDUAL OPHTHALMIC EXAMINATION FINDINGS __________________________________~~~~~ EXAMINER: DAW INPUT BY: JLK EXAM ~( WEEK 1) ANIMAL NO. DOSE GROUP SEX FINDING GRADE 69383 100 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69385 100 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69392 100 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69402 100 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69408 100 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69415 100 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69427 100 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69431 100 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 CODE: l SLIGHT, 2 MODERATE, 3 SEVERE, P PRESENT, O. D. RIGHT EYE, O. S. LEFT EYE PEXv4.0 01/ 18/ 2002 TABLE 29 (WEEK 12 EVALUATION) PROJECT NO.: WIL 417002 PO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE PAGE 1 INDIVIDUAL OPHTHALMIC EXAMINATION FINDINGS ______________~ EXAMINER: DAW INPUT BY: HGG EXAM 2( WEEK 12) ANIMAL NO. DOSE GROUP SEX FINDING GRADE ____________________________________~~~ 69302 0 PPM MALE CORNEAL CRYSTALS  BILATERAL 69306 0 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69308 0 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69310 0 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69312 0 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69314 0 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69317 0 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69322 0 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69337 0 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69343 0 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69305 15 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69316 1 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 69320 15 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69323 15 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69326 1 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 69335 1 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 69336 15 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69338 1 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 69345 1 15 PPM MALE CORNEAL CRYSTALS  BILATERAL 69347 15 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69303 40 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69309 40 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69313 40 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 69315 40 PPM 1 MALE CORNEAL CRYSTALS  BILATERAL 1 CODE: l SLIGHT, 2 MODERATE, 3 SEVERE, P PRESENT, O. D. RIGHT EYE, O. S. LEFT EYE PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 29 (WEEK 12 EVALUATION) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL OPHTHALMIC EXAMINATION FINDINGS PAGE 2 ____________________~~~~~~~~~~~~~~~~~ EXAMINER: DAW INPUT BY: HGG EXAM 2( WEEK 12) ANIMAL NO. DOSE GROUP SEX FINDING GRADE 69324 40 PPM MALE CORNEAL  CRYSTALS BILATERAL 1 69328 40 PPM MALE CORNEAL CRYSTALS BILATERAL  1 69339 40 PPM MALE CORNEAL  CRYSTALS BILATERAL 1 69344 40 PPM MALE CORNEAL CRYSTALS BILATERAL  69348 1 40 PPM MALE CORNEAL CRYSTALS BILATERAL  1 69350 40 PPM MALE CORNEAL  CRYSTALS BILATERAL 1 69304 100 PPM MALE CORNEAL  CRYSTALS BILATERAL 1 69307 100 PPM MALE CORNEAL CRYSTALS BILATERAL  1 69318 100 PPM MALE CORNEAL CRYSTALS BILATERAL  1 69319 100 PPM MALE CORNEAL CRYSTALS BILATERAL  1 69327 100 PPM MALE CORNEAL CRYSTALS BILATERAL  1 69329 100 PPM MALE CORNEAL CRYSTALS BILATERAL  1 69332 100 PPM MALE CORNEAL CRYSTALS BILATERAL  1 69334 100 PPM MALE CORNEAL  CRYSTALS BILATERAL 1 69342 100 PPM MALE CORNEAL  CRYSTALS BILATERAL 1 69346 100 PPM MALE CORNEAL CRYSTALS BILATERAL  1 CATARACT  UNILATERAL 3 O. S. 69354 0 PPM FEMALE CORNEAL  CRYSTALS BILATERAL 1 69366 0 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69367 0 PPM FEMALE CORNEAL  CRYSTALS UNILATERAL 1 O. S. CORNEAL CRYSTALS  UNILATERAL 2 O. D. KERATITIS  UNILATERAL 2 O. D.

CODE: l SLIGHT, 2 MODERATE, 3 SEVERE, P PRESENT, O. D. RIGHT EYE, O. S. LEFT EYE PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 29 (WEEK 12 EVALUATION) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL OPHTHALMIC EXAMINATION FINDINGS PAGE 3 EXAMINER: DAW INPUT BY: HGG EXAM ~( WEEK 12) ANIMAL NO. DOSE GROUP SEX FINDING GRADE _____________________________________ 69378 0 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69384 0 PPM 69398 0 PPM FEMALE CORNEAL CRYSTALS  BILATERAL i FEMALE CORNEAL CRYSTALS  BILATERAL 1 69404 0 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69416 0 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69419 0 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69432 0 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69362 15 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69376 15 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69382 15 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69390 15 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69393 15 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69396 15 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69409 15 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69413 15 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 8 69435 69359 40 15 PPM PPM FEMALE FEMALE CORNEAL CORNEAL CRYSTALS CRYSTALS   BILATERAL BILATERAL 1 1 r 69369 69370 40 40 PPM PPM FEMALE FEMALE CORNEAL CORNEAL CRYSTALS CRYSTALS   BILATERAL BILATERAL 1 1 r 69380 40 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 cn 69388 40 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 z 69394 40 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69426 40 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 69428 40 PPM FEMALE CORNEAL CRYSTALS  BILATERAL 1 I CODE: l SLIGHT, 2 MODERATE, 3 SEVERE, P PRESENT, O. D. RIGHT EYE, O. S. LEFT EYE I TABLE 29 (WEEK 12 EVALUATION) PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 4 SPONSOR: HAP TASK FORCE INDIVIDUAL OPHTHALMIC EXAMINATION FINDINGS ____________________________________ EXAMINER: DAW INPUT BY: HGG EXAM 2tWEEK 12) ANIMAL NO. DOSE GROUP ______ ________________ 69433 40 PPM 69436 40 PPM 69375 100 PPM 69379 100 PPM 69383 100 PPM 69385 100 PPM 69392 100 PPM 69402 100 PPM 69408 100 PPM 69415 100 PPM 69427 100 PPM 69431 100 PPM __ SEX ______________ FEMALE FEMALE FEMALE FEMALE FEMALE FEMALE FEMALE FEMALE FEMALE FEMALE FEMALE FEMALE FINDING _________________ CORNEAL CRYSTALS  CORNEAL CRYSTALS  CORNEAL CRYSTALS  CORNEAL CRYSTALS  CORNEAL CRYSTALS  CORNEAL CRYSTALS  CORNEAL CRYSTALS  CORNEAL CRYSTALS  CORNEAL CRYSTALS  CORNEAL CRYSTALS  CORNEAL CRYSTALS  CORNEAL CRYSTALS  BILATERAL BILATERAL BILATERAL BILATERAL BILATERAL BILATERAL BILATERAL BILATERAL BILATERAL BILATERAL BILATERAL BILATERAL GRADE ___________________

1 1 1 1 1 1 1 1 1 1 1 1 CODE: l SLIGHT, 2 MODERATE, 3 SEVERE, P PRESENT, O. D. RIGHT EYE, O. S. LEFT EYE PEXv4.0 01/ 18/ 2002 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 30 (UNSCHEDULED DEATH) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 1 ANIMAL NO. 69377 GROUP 2: 15 PPM FEMALE EUTH IN EXTREMIS 06/ 30/ 01 DATE OF DEATH: 06/ 30/ 01 STUDY DAY: 30 GRADE _____________________________________~~~ JEJUNUM GROSS: CONTENTS, DARK RED P LIVER GROSS: PALE P ALL LOBES LUNGS GROSS: AREA( S), DARK RED P FEW, IRREGULARLY SHAPED, RIGHT DIAPHRAGMATIC LOBE SKIN GROSS: MATTING, RED P OCULAR, BILATERAL STOMACH GROSS: CONTENTS, DARK RED P NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM BRAIN CECUM COLON DUODENUM LAC GLAND, EXOR ESOPHAGUS EYES/ OPTIC N. HARDERIAN GLANDS HEART ILEUM KIDNEYS AORTA MAMMARY GLAND LARYNX NERVE, SCIATIC LYMPH NODE, TR/ BR LYMPH NODE, MED NASAL TISSUES OVARIES PANCREAS OVIDUCTS THYMUS RECTUM PITUITARY SAL. GLAND MAND SKELETAL MUSCLE SPINAL CORD SPLEEN THYROID GLANDS TRACHEA URINARY BLADDER UTERUS VAGINA GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PGRHv4.28 01/ 18/ 2002 PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 1 ANIMAL NO. 69302 GROUP 1: 0 ________. ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDS/ PARA FINAL BODY WT( G) .___  ____ ABS.( G) 1.83 8.57 1.89 1.25 0.99 0.55 0.99 2.87 0.1814 0.0451 0.0197 305. _ _ _ _ _ _ _ _ _ _ REL. 0.600 2.810 0.620 0.410 0.325 0.180 0.325 0.941 0.059 0.015 0.006 PPM MALE SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 GRADE NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM BRAIN CECUM COLON DUODENUM LAC GLAND, EXOR EPIDIDYMIDES ESOPHAGUS EYES/ OPTIC N. HARDERIAN GLANDS HEART ILEUM JEJUNUM KIDNEYS LIVER AORTA LUNGS LARYNX NERVE, SCIATIC LYMPH NODE, TR/ BR LYMPH NODE, MED NASAL TISSUES PANCREAS TESTES THYMUS RECTUM PITUITARY PROSTATE SAL. GLAND MAND SEMINAL VESICLES SKELETAL MUSCLE SKIN SPINAL CORD SPLEEN STOMACH THYROID GLANDS TRACHEA URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT TABLE 31 (PRIMARY NECROPSY) PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 2 SPONSOR: HAP TASK FORCE INDIVIDUAL MACROSCOPIC FINDINGS ANIMAL NO. 69306 GROUP 1:

___________. ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDS/ PAPA FINAL BODY WT( G) ABS. (G) 1.81 8.25 2.09 1.15 0.90 0.53 0.98 3.16 0.1619 0.0595 0.0212 REL. 0.622 2.835 0.718 0.395 0.309 0.182 0.337 1.086 0.056 0.020 0.007 0 PPM MALE SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 GRADE _______________________________________~~ NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM BRAIN CECUM COLON DUODENUM LAC GLAND, EXOR EPIDIDYMIDES ESOPHAGUS EYES/ OPTIC N. HARDERIAN GLANDS HEART ILEUM JEJUNUM KIDNEYS LIVER AORTA LUNGS LARYNX NERVE, SCIATIC LYMPH NODE, TR/ BR LYMPH NODE, MED NASAL TISSUES PANCREAS TESTES THYMUS RECTUM PITUITARY PROSTATE SAL. GLAND MAND SEMINAL VESICLES SKELETAL MUSCLE SKIN SPINAL CORD SPLEEN STOMACH THYROID GLANDS TRACHEA URINARY BLADDER 291. PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 3 ANIMAL NO. 69308 GROUP 1:

__________. ORGAN WEIGHT ABS.( G) BRAIN 1.88 LIVER 8.40 KIDNEYS 1.97 LUNGS 1.10 HEART 0.98 SPLEEN 0.58 EPIDIDYMIDES 1.00 TESTES 3.03 0 PPM MALE ._______________. REL. LUNGS 0.667 2.979 LYMPH NODE, TR/ BR 0.699 LYMPH NODE, MED 0.390 SKIN 0.348 0.206 NO SIGNIFICANT 0.355 CHANGES OBSERVED 1.074 SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 GRADE GROSS: AREA( S), WHITE FEW, IRREGULARLY SHAPED, GROSS: DISCOLORATION, DARK RED GROSS: DISCOLORATION, DARK RED GROSS: MATTING, RED OCULAR, LEFT P ALL LOBES P P P GROSS: ADRENAL GLANDS STERNUM BRAIN CECUM COLON DUODENUM LAC GLAND. EXOR EPIDIDYMIDES THYMUS 0.1835 0.065 ESOPHAGUS EYES/ OPTIC N. HARDERIAN'GLANDS HEART ADRENAL GLANDS 0.0627 0.022 ILEUM JEJUNUM KIDNEYS LIVER THYROIDS/ PARA 0.0208 0.007 AORTA LARYNX NERVE, SCIATIC NASAL TISSUES FINAL BODY WT( G) 282. PANCREAS TESTES THYMUS RECTUM PITUITARY PROSTATE SAL. GLAND MAND SEMINAL VESICLES SKELETAL MUSCLE SPINAL CORD SPLEEN STOMACH THYROID GLANDS TRACHEA URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT TABLE 31 (PRIMARY NECR~ PSY) PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 4 SPONSOR: HAP TASK FORCE INDIVIDUAL MACROSCOPIC FINDINGS ANIMAL NO. 69310 GROUP 1: 0 PPM MALE SCHEDULED EUTH 08/ 31/ 01 DATE OF DEATH: 08/ 31/ 01 STUDY DAY: 92 GRADE ____________________________________

ORGAN WEIGHT ABS.( G) REL. GENERAL COMMENT GROSS: MECHANICAL TRAUMA P BRAIN 1.73 0.655 DISTAL TAIL BROKEN LIVER 7.35 2.784 NO SIGNIFICANT KIDNEYS 1.87 0.708 CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM BRAIN CECUM LUNGS 1.15 0.436 COLON DUODENUM LAC GLAND, EXOR EPIDIDYMIDES HEART 0.95 0.360 ESOPHAGUS EYES/ OPTIC N. HARDERIAN GLANDS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS 0.54 0.205 ILEUM JEJUNUM KIDNEYS LIVER 0.99 0.375 AORTA LUNGS LARYNX NERVE. SCIATIC 2.79 1.057 LYMPH NODE, TR/ BR LYMPH NODE, MED NASAL TISSUES PANCREAS 0.1835 0.070 TESTES THYMUS RECTUM PITUITARY ADRENAL GLANDS 0.0546 0.021 PROSTATE SAL. GLAND MAND SEMINAL VESICLES SKELETAL MUSCLE THYROIDS/ PARA 0.0112 0.004 SKIN SPINAL CORD SPLEEN STOMACH FINAL BODY WT( G) 264. THYROID GLANDS TRACHEA URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT TABLE 31 (PRIMARY NECROPSY) PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 5 SPONSOR: HAP TASK FORCE INDIVIDUAL MACROSCOPIC FINDINGS ANIMAL NO. 69312 GROUP 1: 0 PPM MALE SCHEDULED EUTH 08/ 31/ 01 DATE OF DEATH: 08/ 31/ 01 STUDY DAY: 92 _____________ ._________. ORGAN WEIGHT ABS. (G) BRAIN 1.88 LIVER 8.46 KIDNEYS 2.16 LUNGS 1.25 HEART 1.01 SPLEEN 0.66 EPIDIDYMIDES 1.04 TESTES 3.43 THYMUS 0.2075 ADRENAL GLANDS 0.0638 THYROIDS/ PARA 0.0148 FINAL BODY WT( G) 316. ._____ __ REL. 0.595 2.677 0.684 0.396 0.320 0.209 0.329 1.085 0.066 0.020 0.005 NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM COLON DUODENUM ESOPHAGUS EYES/ OPTIC N. ILEUM JEJUNUM AORTA LUNGS LYMPH NODE, TR/ BR LYMPH NODE, MED TESTES THYMUS PROSTATE SAL. GLAND MAND SKIN SPINAL CORD THYROID GLANDS TRACHEA GRADE BRAIN CECUM LAC GLAND, EXOR EPIDIDYMIDES HARDERIAN'GLANDS HEART KIDNEYS LIVER LARYNX NERVE, SCIATIC NASAL TISSUES PANCREAS RECTUM PITUITARY SEMINAL VESICLES SKELETAL MUSCLE SPLEEN STOMACH URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT TABLE 31 (PRIMARY NECROPSY) PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 6 SPONSOR: HAP TASK FORCE INDIVIDUAL MACROSCOPIC FINDINGS ANIMAL NO. 69314 GROUP 1: 0 PPM _________________ ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDS/ PARA FINAL BODY WT( G) ABS.( G) 1.74 7.49 1.87 1.19 0.85 0.57 0.90 2.98 0.1740 0.0487 0.0151 281. REL. 0.619 2.665 0.665 0.423 0.302 0.203 0.320 1.060 0.062 0.017 0.005 MALE SCHEDULED EUTH 08/ 31/ 01 DATE OF DEATH: 08/ 31/ 01 STUDY DAY: 92 GRADE SKIN GROSS: MATTING, RED P OCULAR, LEFT NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM BRAIN CECUM COLON DUODENUM LAC GLAND, EXOR EPIDIDYMIDES ESOPHAGUS EYES/ OPTIC N. HARDERIAN GLANDS HEART ILEUM JEJUNUM KIDNEYS LIVER AORTA LUNGS LARYNX NERVE, SCIATIC LYMPH NODE, TR/ BR LYMPH NODE, MED NASAL TISSUES PANCREAS TESTES THYMUS RECTUM PITUITARY PROSTATE SAL. GLAND MAND SEMINAL VESICLES SKELETAL MUSCLE SPINAL CORD SPLEEN STOMACH THYROID GLANDS TRACHEA URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE ANIMAL NO. 69317 GROUP 1: 0 PPM MALE ______________ ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDS/ PARA FINAL BODY WT( G) _______ ABS.( G) 1.84 8.37 2.02 1.21 0.69 0.59 0.91 3.13 0.2070 0.0393 0.0105 309. TABLE 31 (PRIMARY NECROPSY) PO DAY INHAL. STUDY OF 1,1,2 TCE IN FATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE I SCHEDULED EUTH 08/ 31/ 01 DATE OF DEATH: 08/ 31/ 01 STUDY DAY: 92 GRADE REL. NO SIGNIFICANT 0.595 CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM BRAIN CECUM 2.709 COLON DUODENUM LAC GLAND, EXOR EPIDIDYMIDES 0.654 ESOPHAGUS EYES/ OPTIC N. HARDERIAN GLANDS HEART 0.392 ILEUM JEJUNUM KIDNEYS LIVER 0.288 AORTA LUNGS LARYNX NERVE. SCIATIC 0.191 LYMPH NODE, TR/ BR LYMPH NODE, MED NASAL TISSUES PANCREAS 0.294 TESTES THYMUS RECTUM PITUITARY 1.013 0.067 0.013 0.003 PROSTATE SAL. GLAND MAND SEMINAL VESICLES SKELETAL MUSCLE SKIN SPINAL CORD SPLEEN STOMACH THYROID GLANDS TRACHEA URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT TABLE 31 (PRIMARY NECROPSY) PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 8 SPONSOR: HAP TASK FORCE INDIVIDUAL MACROSCOPIC FINDINGS ANIMAL NO. 69322 GROUP 1: 0 PPM ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDS/ PARA FINAL BODY WT( G) ABS.( G) 1.85 7.44 2.00 1.26 0.87 0.50 0.94 2.99 0.1670 0.0602 0.0146 280. MALE REL. NO SIGNIFICANT 0.661 CHANGES OBSERVED 2.657 0.714 0.450 0.311 0.179 0.336 1.068 0.060 0.021 0.005 SCHEDULED EUTH 08/ 31/ 01 DATE OF DEATH: 08/ 31/ 01 STUDY DAY: 92 GRADE GROSS: ADRENAL GLANDS STERNUM COLON DUODENUM ESOPHAGUS EYES/ OPTIC N. ILEUM JEJIJNUM AORTA LUNGS LYMPH NODE, TR/ BR LYMPH NODE, MED TESTES THYMUS PROSTATE SAL. GLAND MAND SKIN SPINAL CORD THYROID GLANDS TRACHEA BRAIN CECUM LAC GLAND, EXOR EPIDIDYMIDES HARDERIAN GLANDS HEART KIDNEYS LIVER LARYNX NERVE, SCIATIC NASAL TISSUES PANCREAS RECTUM PITUITARY SEMINAL VESICLES SKELETAL MUSCLE SPLEEN STOMACH URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 9 ANIMAL NO. 69337 GROUP 1: 0 PPM MALE SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 GRADE ______________________________________

ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDS/ PARA FINAL BODY WT( G) ABS.( G) 1.84 8.03 1.92 1.18 1.02 0.55 1.07 3.10 0.1882 0.0592 0.0228 284. REL. NO SIGNIFICANT 0.648 CHANGES OBSERVED 2.827 0.676 0.415 0.359 0.194 0.377 1.092 0.066 0.021 0.008 GROSS: ADRENAL GLANDS STERNUM COLON DUODENUM ESOPHAGUS EYES/ OPTIC N. ILEUM JEJUNUM AORTA LUNGS LYMPH NODE, TR/ BR LYMPH NODE, MED TESTES THYMUS PROSTATE SAL. GLAND MAND SKIN SPINAL CORD THYROID GLANDS TRACHEA BRAIN LAC GLAND, EXOR HARDERIAN GLANDS KIDNEYS LARYNX NASAL TISSUES RECTUM SEMINAL VESICLES SPLEEN URINARY BLADDER CECUM EPIDIDYMIDES HEART LIVER NERVE, SCIATIC PANCREAS PITUITARY SKELETAL MUSCLE STOMACH GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT TABLE 31 (PRIMARY NECROPSY) PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 10 SPONSOR: HAP TASK FORCE INDIVIDUAL MACROSCOPIC FINDINGS ANIMAL NO. 69343 GROUP 1: 0 PPM MALE SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 _________________ _ _ _ _ _ _ _ _ _ ORGAN WEIGHT ABS.( G) BRAIN 1.83 LIVER 7.80 KIDNEYS 1.80 LUNGS 1.18 HEART 0.89 SPLEEN 0.61 EPIDIDYMIDES 0.91 TESTES 2.83 THYMUS 0.1493 ADRENAL GLANDS 0.0518 THYROIDS/ PARA 0.0192 FINAL BODY WT( G) 263. ._____ REL. 0.696 2.966 0.684 0.449 0.338 0.232 0.346 1.076 0.057 0.020 0.007 _______________________________ NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM COLON DUODENUM ESOPHAGUS EYES/ OPTIC N. ILEUM JEJUNUM AORTA LUNGS LYMPH NODE, TR/ BR LYMPH NODE, MED TESTES THYMUS PROSTATE SAL. GLAND MAND SKIN SPINAL CORD THYROID GLANDS TRACHEA GRADE _________________________________

BRAIN CECUM LAC GLAND, EXOR EPIDIDYMIDES HARDERIAN GLANDS HEART KIDNEYS LIVER LARYNX NERVE, SCIATIC NASAL TISSUES PANCREAS RECTUM PITUITARY SEMINAL VESICLES SKELETAL MUSCLE SPLEEN STOMACH URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 11 ANIMAL NO. 69305 GROUP 2: 15 PPM MALE SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 GRADE _____________________________________ ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDS/ PARA FINAL BODY WT( G) ABS. (G) 1.87 7.12 1.87 0.96 0.81 0.49 0.96 3.04 1.165 0.1574 0.060 0.0607 0.0213 261. REL. 0.716 2.728 0.716 0.368 0.310 0.188 0.368 0.023 0.008 LYMPH NODE, MED GROSS: DISCOLORATION, DARK RED NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM COLON DUODENUM ESOPHAGUS EYES/ OPTIC N. ILEUM JEJUNUM AORTA LUNGS LYMPH NODE, TR/ BR NASAL TISSUES THYMUS RECTUM SAL. GLAND MAND SEMINAL VESICLES SPINAL CORD SPLEEN TRACHEA URINARY BLADDER P BRAIN CECUM LAC GLAND, EXOR EPIDIDYMIDES HARDERIAN GLANDS HEART KIDNEYS LIVER LARYNX NERVE, SCIATIC PANCREAS TESTES PITUITARY PROSTATE SKELETAL MUSCLE SKIN STOMACH THYROID GLANDS GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 12 ANIMAL NO. 69316 GROUP 2: 15 PPM MALE SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 GRADE ______________________________________ ORGAN WEIGHT ABS.( G) BRAIN 1.92 LIVER 9.78 KIDNEYS 2.25 LUNGS 1.34 HEART 1.00 SPLEEN 0.70 EPIDIDYMIDES 0.99 TESTES 3.39 THYMUS 0.2055 ADRENAL GLANDS 0.0629 THYROIDS/ PARA 0.0208 FINAL BODY WT( G) 307. REL. 0.625 3.186 0.733 0.436 0.326 0.228 0.322 1.104 0.067 0.020 0.007 NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM COLON DUODENUM ESOPHAGUS EYES/ OPTIC N. ILEUM JEJUNUM AORTA LUNGS LYMPH NODE, TR/ BR LYMPH NODE, MED TESTES THYMUS PROSTATE SAL. GLAND MAND SKIN SPINAL CORD THYROID GLANDS TRACHEA BRAIN CEC UM LAC GLAND, EXOR EPIDIDYMIDES HARDERIAN GLANDS HEART KIDNEYS LIVER LARYNX NERVE, SCIATIC NASAL TISSUES PANCREAS RECTUM PITUITARY SEMINAL VESICLES SKELETAL MUSCLE SPLEEN STOMACH URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT TABLE 31 (PRIMARY NECROPSY) PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH'PK IN RATS & MICE PAGE 13 SPONSOR: HAP TASK FORCE INDIVIDUAL MACROSCOPIC FINDINGS ANIMAL NO. 69320 GROUP 2: 15 PPM MALE SCHEDULED EUTH 08/ 31/ 01 DATE OF DEATH: 08/ 31/ 01 STUDY DAY: 92 GRADE __ ___________^____ ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDS/ PARA FINAL BODY WT( G) LUNGS GROSS: AREA( S), WHITE FEW, IRREGULARLY SHAPED, ALL LOBES PANCREAS GROSS: PALE NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM BRAIN _________

ABS.( G) REL. 1.87 0.590 a. 75 2.760 2.20 0.694 1.40 0.442 1.00 0.315 0.62 0.196 0.95 0.300 3.08 0.972 0.2047 0.065 0.0537 0.017 P P COLON DUODENUM ESOPHAGUS EYES/ OPTIC N. ILEUM JEJUNUM AORTA LARYNX LYMPH NODE, MED NASAL TISSUES RECTUM PITUITARY SEMINAL VESICLES SKELETAL MUSCLE SPLEEN STOMACH URINARY BLADDER LAC GLAND, EXOR HARDERIAN GLANDS KIDNEYS NERVE, SCIATIC TESTES PROSTATE SKIN THYROID GLANDS CECUM EPIDIDYMIDES HEART LIVER LYMPH NODE, TR/ BR THYMUS SAL. GLAND MAND SPINAL CORD TRACHEA 0.0170 0.005 317.

GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 14 INDIVIDUAL MACROSCOPIC FINDINGS ANIMAL NO. 69323 GROUP 2: 15 PPM MALE SCHEDULED EUTH 08/ 31/ 01 DATE OF DEATH: 08/ 31/ 01 STUDY DAY: 92 GRADE ________ ORGAN WEIGHT ABS.( G) REL. NO SIGNIFICANT BRAIN 1.84 0.570 CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM BRAIN CECUM LIVER 8.85 2.740 COLON DUODENUM LAC GLAND. EXOR EPIDIDYMIDES KIDNEYS 2.11 0 LUNGS 1.31 0 HEART 0.99 0 SPLEEN 0.60 0 EPIDIDYMIDES 0.96 0 TESTES 3.11 0 THYMUS 0.1898 0 ADRENAL GLANDS 0.0577 0 THYROIDS/ PARA 0.0178 0 FINAL BODY WT( G) 323. 653 ESOPHAGUS EYES/ OPTIC N. 406 ILEUM JEJUNUM 307 186 297 963 059 018 006 AORTA LUNGS LYMPH NODE, TR/ BR LYMPH NODE, MED TESTES THYMUS PROSTATE SAL. GLAND MAND SKIN SPINAL CORD THYROID GLANDS TRACHEA HARDERIAN'GLANDS HEART KIDNEYS LIVER LARYNX NERVE, SCIATIC NASAL TISSUES PANCREAS RECTUM PITUITARY SEMINAL VESICLES SKELETAL MUSCLE SPLEEN STOMACH URINARY BLADDER GROSS GRADE CODE: l SLIGHT, Z MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 15 ANIMAL NO. 69326 GROUP 2: 15 PPM MALE SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 GRADE _____________________________________~

ORGAN WEIGHT ABS.( G) BRAIN 1.98 LIVER 8.99 KIDNEYS 2.19 LUNGS 1.40 HEART 0.98 SPLEEN 0.67 EPIDIDYMIDES 1.09 TESTES 3.39 THYMUS 0.2244 ADRENAL GLANDS 0.0521 THYROIDS/ PARA 0.0249 FINAL BODY WT( G) 334. REL. 0.593 2.692 0.656 0.419 0.293 0.201 0.326 1.015 0.067 0.016 0.007 NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS COLON ESOPHAGUS ILEUM AORTA LYMPH NODE, TR/ BR TESTES PROSTATE SKIN THYROID GLANDS STERNUM BRAIN CECUM DUODENUM LAC GLAND, EXOR EPIDIDYMIDES EYES/ OPTIC N. HARDERIAN GLANDS HEART JEJUNUM KIDNEYS LIVER LUNGS LARYNX NERVE, SCIATIC LYMPH NODE, MED NASAL TISSUES PANCREAS THYMUS RECTUM PITUITARY SAL. GLAND MAND SEMINAL VESICLES SKELETAL MUSCLE SPINAL CORD SPLEEN STOMACH TRACHEA URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE ANIMAL NO. 69335 GROUP 2:

________ ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDS/ PARA FINAL BODY WT( G) ___ _ _ _ _ _ _ _ _ ABS. (G) REL. 1.95 0.609 8.86 2.769 2.24 1.26 1.08 0.67 1.03 3.24 0.1967 0.0541 0.0145 320. TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 16 0.700 0.394 0.338 0.209 0.322 1.012 0.061 0.017 0.005 15 PPM MALE SCHEDULED EUTH 08/ 31/ 01 DATE OF DEATH: 08/ 31/ 01 STUDY DAY: 92 GRADE NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM BRAIN CECUM COLON DUODENUM LAC GLAND, EXOR EPIDIDYMIDES ESOPHAGUS EYES/ OPTIC N. HARDERIAN GLANDS HEART ILEUM JEJUNUM KIDNEYS LIVER AORTA LUNGS LARYNX NERVE, SCIATIC LYMPH NODE, TR/ BR LYMPH NODE, MED NASAL TISSUES PANCREAS TESTES THYMUS RECTUM PITUITARY PROSTATE SAL. GLAND MAND SEMINAL VESICLES SKELETAL MUSCLE SKIN SPINAL CORD SPLEEN STOMACH THYROID GLANDS TRACHEA URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 17 ANIMAL NO. 69336 GROUP 2: 15 PPM MALE SCHEDULED EUTH 08/ 31/ 01 DATE OF DEATH: 08/ 31/ 01 STUDY DAY: 92 GRADE ____________________________________ ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDSIPARA FINAL BODY WT( G) ABS.( G) 1.86 8.71 2.08 1.21 REL. 0.620 0.99 0.60 0.94 2.90 0.2001 0.0618 0.0146 300. 2.903 0.693 0.403 0.330 0.200 0.313 0.967 0.067 0.021 0.005 NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM COLON DUODENUM ESOPHAGUS EYES/ OPTIC N. ILEUM JEJUNUM AORTA LUNGS LYMPH NODE, TR/ BR LYMPH NODE, MED TESTES THYMUS PROSTATE SAL. GLAND MAND SKIN SPINAL CORD THYROID GLANDS TRACHEA BRAIN CECUM LAC GLAND, EXOR EPIDIDYMIDES HARDERIAN GLANDS HEART KIDNEYS LIVER LARYNX NERVE, SCIATIC NASAL TISSUES PANCREAS RECTUM PITUITARY SEMINAL VESICLES SKELETAL MUSCLE SPLEEN STOMACH URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 18 ANIMAL NO. 69338 GROUP 2: 15 PPM MALE SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 GRADE _______________________________________ ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDS/ PARA FINAL BODY WT( G) ABS.( G) 1.87 7.22 1.81 1.11 0.88 0.56 0.94 3.13 0.1938 0.0564 0.0146 273. REL. 0.685 2.645 0.663 0.407 0.322 0.205 0.344 1.147 0.071 0.021 0.005 SKIN GROSS: MATTING, RED P OCULAR, LEFT NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM BRAIN CECUM COLON DUODENUM LAC GLAND, EXOR EPIDIDYMIDES ESOPHAGUS EYES/ OPTIC N. HARDERIAN GLANDS HEART ILEUM JEJUNUM KIDNEYS LIVER AORTA LUNGS LARYNX NERVE, SCIATIC LYMPH NODE, TRj /BR LYMPH NODE, MED NASAL TISSUES PANCREAS TESTES THYMUS RECTUM PITUITARY PROSTATE SAL. GLAND MAND SEMINAL VESICLES SKELETAL MUSCLE SPINAL CORD SPLEEN STOMACH THYROID GLANDS TRACHEA URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT TABLE 31 (PRIMARY NECROPSY) PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS Es MICE PAGE 19 SPONSOR: HAP TASK FORCE INDIVIDUAL MACROSCOPIC FINDINGS ANIMAL NO. 69345 GROUP 2: 15 PPM MALE SCHEDULED EUTH 08/ 31/ 01 DATE OF DEATH: 08/ 31/ 01 STUDY DAY: 92 GRADE ORGAN WEIGHT ABS.( G) BRAIN 2.01 LIVER 8.66 KIDNEYS 2.29 LUNGS 1.27 HEART 0.98 SPLEEN 0.65 EPIDIDYMIDES 1.08 TESTES 3.20 THYMUS 0.2254 ADRENAL GLANDS 0.0587 THYROIDS/ PARA 0.0139 FINAL BODY WT( G) 307. REL. NO SIGNIFICANT 0.655 CHANGES OBSERVED 2.821 0.746 0.414 0.319 0.212 0.352 1.042 0.073 0.019 0.005 GROSS: ADRENAL GLANDS STERNUM COLON DUODENUM ESOPHAGUS EYES/ OPTIC N. ILEUM JEJUNUM AORTA LUNGS LYMPH NODE, TR/ BR LYMPH NODE, MED TESTES THYMUS PROSTATE SAL. GLAND MAND SKIN SPINAL CORD THYROID GLANDS TRACHEA BRAIN CECUM LAC GLAND, EXOR EPIDIDYMIDES HARDERIAN GLANDS HEART KIDNEYS LIVER LARYNX NERVE, SCIATIC NASAL TISSUES PANCREAS RECTUM PITUITARY SEMINAL VESICLES SKELETAL MUSCLE SPLEEN STOMACH URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 20 ANIMAL NO. 69347 GROUP 2: 15 PPM MALE SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 GRADE _________________________________ ORGAN WEIGHT ABS.( G) REL. SEMINAL VESICLES GROSS: SMALL P BRAIN 1.76 0.624 RIGHT LIVER 8.02 2.844 NO SIGNIFICANT KIDNEYS 1.99 LUNGS 1.23 HEART 0.87 SPLEEN 0.59 EPIDIDYMIDES 0.88 TESTES 2.73 THYMUS 0.2210 ADRENAL GLANDS 0.0519 THYROIDS/ PARA 0.0253 FINAL BODY WT( G) 282. 706 436 309 209 312 968 078 018 009 CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM COLON DUODENUM ESOPHAGUS EYES/ OPTIC N. ILEUM JEJUNUM AORTA LUNGS LYMPH NODE, TR/ BR LYMPH NODE, MED TESTES THYMUS PROSTATE SAL. GLAND MAND SPINAL CORD SPLEEN TRACHEA URINARY BLADDER BRAIN CECUM LAC GLAND, EXOR EPIDIDYMIDES HARDERIAN GLANDS HEART KIDNEYS LIVER LARYNX NERVE, SCIATIC NASAL TISSUES PANCREAS RECTUM PITUITARY SKELETAL MUSCLE SKIN STOMACH THYROID GLANDS GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 21 INDIVIDUAL MACROSCOPIC FINDINGS ANIMAL NO. 69303 GROUP 3: 40 PPM MALE SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 GRADE _____________________________________~ ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDS/ PARA FINAL BODY NT( G) ABS. (G) 1.61 6.40 1.76 0.99 0.89 0.47 0.184 0.80 0.314 2.68 0.0972 0.0495 0.0144 255. REL. 0.631 2.510 0.690 0.388 0.349 1.051 0.038 0.019 0.006 NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM COLON DUODENUM ESOPHAGUS EYES/ OPTIC N. ILEUM JEJUNUM AORTA LUNGS LYMPH NODE, TR/ BR LYMPH NODE, MED TESTES THYMUS PROSTATE SAL. GLAND MAND SKIN SPINAL CORD THYROID GLANDS TRACHEA BRAIN CECUM LAC GLAND, EXOR EPIDIDYMIDES HARDERIAN GLANDS HEART KIDNEYS LIVER LARYNX NERVE, SCIATIC NASAL TISSUES PANCREAS RECTUM PITUITARY SEMINAL VESICLES SKELETAL MUSCLE SPLEEN STOMACH URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE PAGE 22 INDIVIDUAL MACROSCOPIC FINDINGS ANIMAL NO. 69309 GROUP 3:

_____________ ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS THYROIDS/ PARA FINAL BODY WT( G) ____  ___ ABS.( G) 1.89 8.02 2.44 1.39 0.97 0.315 AORTA LUNGS LARYNX NERVE` SCIATIC 0.59 0.192 LYMPH NODE, TR/ BR LYMPH NODE, MED NASAL TISSUES PANCREAS 1.01 3.25 0.2094 0.0654 0.0151 308. REL. 0.614 2.604 0.792 0.451 0.328 1.055 0.068 0.021 0.005 40 PPM MALE SCHEDULED EUTH 08/ 31/ 01 DATE OF DEATH: 08/ 31/ 01 STUDY DAY: 92 GRADE _____________________________________~~ NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM BRAIN CECUM COLON DUODENUM LAC GLAND, EXOR EPIDIDYMIDES ESOPHAGUS EYES/ OPTIC N. HARDERIAN GLANDS HEART ILEUM JEJUNUM KIDNEYS LIVER TESTES THYMUS RECTUM PITUITARY PROSTATE SAL. GLAND MAND SEMINAL VESICLES SKELETAL MUSCLE SKIN SPINAL CORD SPLEEN STOMACH THYROID GLANDS TRACHEA URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) YO DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 23 ANIMAL NO. 69313 GROUP 3: 40 PPM MALE ____________ ORGAN WEIGHT BRAIN LIVER KIDNEYS LUNGS HEART SPLEEN EPIDIDYMIDES TESTES THYMUS ADRENAL GLANDS ABS.( G) 1.91 9.01 2.26 1.22 1.03 0.64 0.96 3.13 0.2268 0.0598 THYROIDS/ PARA 0.0162 FINAL BODY WT( G) 310. ._________________________ REL. NO SIGNIFICANT 0.616 CHANGES OBSERVED 2.906 0.729 0.394 0.332 0.206 0.310 1.010 0.073 0.019 0.005 _. SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 GRADE GROSS: ADRENAL GLANDS STERNUM COLON DUODENUM ESOPHAGUS EYES/ OPTIC N. ILEUM JEJUNUM AORTA LUNGS LYMPH NODE, TR/ BR LYMPH NODE, MED TESTES THYMUS PROSTATE SAL. GLAND MAND SKIN SPINAL CORD THYROID GLANDS TRACHEA BRAIN CECUM LAC GLAND, EXOR EPIDIDYMIDES HARDERIAN GLANDS HEART KIDNEYS LIVER LARYNX NERVE, SCIATIC NASAL TISSUES PANCREAS RECTUM PITUITARY SEMINAL VESICLES SKELETAL MUSCLE SPLEEN STOMACH URINARY BLADDER GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT TABLE 31 (PRIMARY NECROPSY) PROJECT NO.: WIL 417002 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE SPONSOR: HAP TASK FORCE INDIVIDUAL MACROSCOPIC FINDINGS ANIMAL NO. 69315 GROUP __________________ 3:

__ REL. 0.731 2.625 0.688 0.415 0.344 0.166 0.372 1.111 0.071 0.019 0.007 40 PPM MALE SCHEDULED EUTH 08/ 30/ 01 DATE OF DEATH: 08/ 30/ 01 STUDY DAY: 91 GRADE _____________________________________~ NO SIGNIFICANT CHANGES OBSERVED GROSS: ADRENAL GLANDS STERNUM BRAIN CECUM COLON DUODENUM LAC GLAND, EXOR EPIDIDYMIDES ESOPHAGUS EYES/ OPTIC N. HARDERIAN GLANDS HEART ILEUM JEJUNUM KIDNEYS LIVER AORTA LUNGS LARYNX NERVE, SCIATIC LYMPH NODE, TR/ BR LYMPH NODE, MED NASAL TISSUES PANCREAS TESTES THYMUS RECTUM PITUITARY PROSTATE SAL. GLAND MAND SEMINAL VESICLES SKELETAL MUSCLE SKIN SPINAL CORD SPLEEN STOMACH THYROID GLANDS TRACHEA URINARY BLADDER ORGAN WEIGHT ABS.( G) BRAIN 1.85 LIVER 6.64 KIDNEYS 1.74 LUNGS 1.05 HEART 0.87 SPLEEN 0.42 EPIDIDYMIDES 0.94 TESTES 2.81 THYMUS 0.1794 ADRENAL GLANDS 0.0474 THYROIDS/ PAR A 0.0188 FINAL BODY WT( G) 253. PAGE 24 GROSS GRADE CODE: l SLIGHT, 2 MODERATE, 3 MARKED, P PRESENT PROJECT NO.: WIL 417002 SPONSOR: HAP TASK FORCE TABLE 31 (PRIMARY NECROPSY) 90 DAY INHAL. STUDY OF 1,1,2 TCE IN RATS WITH PK IN RATS & MICE INDIVIDUAL MACROSCOPIC FINDINGS PAGE 25 ANIMAL NO. 69324 GROUP 3: