                 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                         WASHINGTON, D.C. 20460

                                                 	OFFICE OF CHEMICAL SAFETY AND
                                                                                POLLUTION PREVENTION

MEMORANDUM

Date:		December 12, 2013

SUBJECT:	Revision to - Linuron: Acute and Chronic Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Section (3) Registration Action on Coriander, Dill, Horseradish, Parsley, Celeriac, Rhubarb, and Dry Pea.

PC Code:  035506
DP Barcode:  D416461
Decision No.:  469722
Registration No.:  61842-23
Petition No.:  2E8083
Regulatory Action:  Section 3
Risk Assessment Type:  Dietary
Case No.:  0047
TXR No.:  N/A
CAS No.:  330-55-2
MRID No.:  N/A
40 CFR:  §180.184

FROM:	Kristin Rury, Biologist
	Risk Assessment Branch III
	Health Effects Division (7509P)

THROUGH:	Thurston Morton, Senior Chemist
	Julie Van Alstine, Environmental Health Scientist
	Dietary Exposure Science Advisory Council (DESAC)

	And

	Christine Olinger, Chief
	Risk Assessment Branch III
	Health Effects Division

TO:	Kristin Rury, Risk Assessor
	Risk Assessment Branch III
	Health Effects Division (7509P)

       And

	Barbara Madden, Risk Manager
	Risk Integration Minor Use and Emergency Response Branch
	Division (7505P)
Executive Summary

Acute and chronic aggregate dietary food and drinking water exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16, which uses food consumption data collected from 2003-2008 from the U.S. Department of Agriculture's (USDA's) National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA).  The analysis was conducted to support a human health risk assessment for the proposed use and tolerances of linuron on coriander, dill, horseradish, parsley, celeriac, rhubarb, and dry pea.   This memo was reviewed by two peer reviewers of the Dietary Exposure Science Advisory Council (DESAC), per the DESAC Standard Operating Procedure (SOP) 2012.1.  This document serves as a revision to the previous assessment, as the tolerance recommendations have changed.

Acute Dietary Exposure Assessment: The acute dietary exposure assessments incorporated recommended and/or established tolerance-level residues, and used DEEM default processing factors.  The acute assessment assumed that all registered and proposed crops were treated (100% crop treated; %CT).  Estimated drinking water concentrations (EDWCs) from the Environmental Fate and Effects Division (EFED) (89.05 ppb) were also included.  Because different toxicological points of departure (PODs) were selected for females 13-49 years old and for the general U.S. population, two separate dietary exposure analyses were conducted.  The results of the acute analysis indicate that the acute dietary (food and drinking water) exposure and risk does not exceed HED's level of concern [i.e., <100% acute population adjusted dose (aPAD)] for the general U.S. population, and all population subgroups, including females 13-49 years old.  At the 95[th] percentile of exposure, the resulting acute dietary (food and drinking water) risk estimates utilized 4.3% of the aPAD for the general U.S. population and 10% for all infants, the most highly exposed population subgroup.  At the 95[th] percentile of exposure, the resulting acute dietary (food and drinking water) risk estimate utilized 5.7% of the aPAD for females 13-49 years old.

Chronic Dietary Exposure Assessment: The chronic dietary (food and drinking water) exposure assessment for linuron incorporated recommended and/or established tolerance-level residues and used DEEM default processing factors.  Average %CT estimates provided by the Biological and Economic Analysis Division (BEAD) were also incorporated into the assessment for the existing uses, and EDWCs from EFED (48.8 ppb) were also included.  The results of the chronic analysis indicate that chronic dietary (food and drinking water) exposure and risk does not exceed HED's level of concern [i.e., <100% chronic population adjusted dose (cPAD)] for the U.S. population and all population subgroups.  The resulting chronic dietary (food and drinking water) risk estimates utilized 22% of the cPAD for the general U.S. population and utilized 60% of the cPAD for children 1-2 years old, the most highly exposed population subgroup.

Cancer Dietary Exposure Assessment: Linuron is classified as a "Group C Carcinogen" and quantification of human cancer risk is not required.

I.  Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population adjusted dose (PAD).  The PAD is equivalent to the point of departure (POD; no observed adverse effect level, NOAEL; lowest observed adverse effect level, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for linuron was conducted by Kristin Rury (D411650, 09/04/2013).

II.  Residue Information

Residues of Concern: The residue definitions for enforcement of tolerance and for risk assessment are identical, namely, linuron and metabolites convertible to 3,4-dichloroaniline (3,4-DCA).  The residues of concern are summarized in Table 1.

The terminal residues of concern in plants, animals, and drinking water are linuron (parent) and metabolites convertible to 3,4-DCA, including 3,4-dichlorophenylurea (DCPU), desmethoxy-linuron (DCPMU), desmethyl linuron, and hydroxy-norlinuron.

Table 1.  Summary of Metabolites and Degradates to be included in the Risk Assessment and Tolerance Expression
Matrix
                     Residues included in Risk Assessment
                   Residues included in Tolerance Expression
Plants
Primary Crop
                                  linuron and
                      metabolites convertible to 3,4-DCA
                linuron and metabolites convertible to 3,4-DCA

Rotational Crop

Livestock
Ruminant

Poultry

Drinking Water

                                Not Applicable

Established Tolerances: Permanent tolerances for linuron are currently established in/on a wide variety of crops (40 CFR §180.184), including a Section 18 registration on lentils (revocation date of 12/31/2014) and on crops with regional registrations.

Recommended Tolerances: The Interregional Research Project No. 4 (IR-4) submitted a petition (PP#2E8083) to allow linuron use on coriander (fresh and seed), dill, horseradish, parsley, and dry pea.  HED previously evaluated exposure risk from linuron use on rhubarb and celeriac during tolerance reassessment (S. Recore, D281845, 03/27/2002); however, the uses are also included in the currently proposed label.  Therefore, HED has reevaluated the risk from linuron use on rhubarb and celeriac.  HED also corrected previous tolerance (K. Rury, D411650, 09/04/2013) recommendations as part of this revision.  The corrected tolerance recommendations are outlined in Table 2.

Residue Data used for Acute and Chronic Assessments: HED used tolerance-level residues for the proposed and registered crops, and assumed that 100% of the registered and proposed crops were treated for the acute assessment, and incorporated average %CT was used for the registered crops when available for the chronic assessment.  DEEM default processing factors were used for dried potato, corn syrup, and dried beef meat.  Table 2 lists HED-recommended tolerances for the proposed crops used in the dietary assessment.

Meat, Milk, Poultry and Eggs: There are no feed items associated with this current petition.  Cowpea commodities would affect the dietary burden of cattle but they are not included in the petition for dry peas.  Dry peas only includes the following commodities listed under 40 CFR§180.1(g): Cajanus cajan (includes pigeon pea); Cicerspp.(includes chickpea and garbanzo bean); Lens culinaris (lentil);Pisumspp.(includes dwarf pea, garden pea, green pea, English pea, field pea, and edible pod pea).  Therefore, the previous livestock dietary intake calculations and resulting tolerance recommendations are not changed.

Table 2.2.2.  Tolerance Summary for Linuron.
                                   Commodity
                           Proposed Tolerance (ppm)
                        HED-Recommended Tolerance (ppm)
                                   Comments
                          (adjustments to tolerances)

                                   DP404359
                                    New DP

                            Cilantro, fresh leaves
                                      3.0
                                      1.5
                                      3.0
                               removed n values
                            Cilantro, dried leaves
                                      27
                                      10
                                      10
                          9X PF x HAFT of 1.055 ppm
                                Coriander, seed
                                     0.01
                                     0.05
                                     0.05
                              5X Mean of 0.01 ppm
                            Dillweed, fresh leaves
                                      1.5
                                      0.6
                                      1.5
                               removed n values
                            Dillweed, dried leaves
                                      7.1
                                      3.0
                                       5
                           9X PF x HAFT of 0.56 ppm
                                  Dill, seed
                                      0.3
                                      0.5
                                      0.5
                              5X Mean of 0.09 ppm
                                   Dill, oil
                                      4.8
                                      2.0
                                       2
                          3.21 PF x HAFT of 0.56 ppm
                                  Horseradish
                                     0.05
                                     0.05
                                     0.05
                                LOQ of 0.05 ppm
                                Parsley, leaves
                                      3.0
                                      4.0
                                       4
                              5X Mean of 0.75 ppm
                             Parsley, dried leaves
                                      8.3
                                      3.0
                                      9.0
                          9X PF x HAFT of 1.015 ppm
                                Pea, dry, seed
                                     0.08
                                     0.06
                                     0.09
                               removed n values

III.  Percent Crop Treated Information

A Screening Level Usage Analysis (SLUA) entitled, "Usage Report Package in Support of a Tolerance Petition for the Herbicide Linuron, BEAN DP# 410336" (J. Alsadek, 04/10/2013) was provided by BEAD.

The acute dietary analysis incorporated 100%CT for all registered and proposed commodities.

The chronic dietary analysis incorporated average %CT data for asparagus (25%), carrots (85%), celery (25%), corn (1.0%), cotton (1.0%), potatoes (5.0%), sorghum (1.0%), soybeans (1.0%), sweet corn (1.0%), and wheat (1.0%).

Please refer to Attachment 5 for the PCT data provided by BEAD.

IV.  Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by EFED (H. Zhong, D405829, 06/25/2013 and H. Zhong, D405829, 06/19/2013) and incorporated directly into this dietary assessment.  Water residues were incorporated in the DEEM-FCID into the food categories "water, direct, all sources" and "water, indirect, all sources."  The drinking water assessment assumes a total toxic residue approach.  The EDWC for surface water from the current assessment (89.05 ppb) is based on the California lettuce scenario and is higher than the previous EDWC estimates.  Thus, the surface water concentration of 89.05 ppb was used for the acute dietary exposure assessments.  The EDWC for ground water (48.8 ppb) based on the Wisconsin corn scenario and is used in the chronic dietary exposure assessment.

EDWCs for the acute assessments were estimated using the Pesticide Root Zone Model- Exposure Analysis Modeling System (PRZM-EXAMS).   The EDWC for the chronic assessment was estimated using PRZM-GW (groundwater).  The EDWCs from D405829 are listed in Table 3.  The models and their descriptions are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/.

Table 3.	Summary of Estimated Surface Water and Groundwater Concentrations (EDWCs) for Linuron Used on Coriander, Dill, Celeriac, Horseradish, Parsley, Dry Peas, and Rhubarb.

                          Surface Water Conc., ppb a
                           Groundwater Conc., ppb b
Acute (non-cancer, peak exposure)
                                     89.05
                                     48.8
Chronic (non-cancer, post-breakthrough average)
                                     48.69

Chronic (cancer, long-term mean)
                                     30.81

[a] Pesticide Root Zone Model (PRZM v3.12.2, May 12, 2005) and Exposure Analysis Modeling System (EXAMS v<IP_ADDRESS>, April 25, 2005), simulation models, were coupled with the input PE5.pl.shell.  The model does incorporate a degradation component.
[b] From the PRZM-GW model.

V.  DEEM-FCID Program and Consumption Information

Linuron acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID, Version 3.16, which incorporates consumption data from 2003 to 2008 from USDA's NHANES/WWEIA.  The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups.  However, for acute exposure assessment, consumption data are retained as individual consumption events.  Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For an acute exposure assessment, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or "matched" in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for analyses performed at all levels of refinement.  However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

VI.  Toxicological Information

The toxicity database for linuron is robust and the data requirements are satisfied.  The HED Hazard and Science Policy Council (HASPOC) waived the required subchronic neurotoxicity, subchronic dermal toxicity, and subchronic inhalation toxicity studies (TXR# 0056667 and TXR# 0056666). With repeated dosing in test animals, linuron produces two primary effects: (1) changes in the hematopoietic system in rats, mice, and dogs; and (2) changes in the male reproductive system in developing rats.

Because different toxicological PODs were selected for females 13-49 years old and for the general U.S. population, two separate dietary exposure analyses were conducted.  To estimate acute dietary exposure to the general U.S. population and remaining population subgroups excluding females 13-49 years old, an oral POD was selected based on decreases in rearing and motor activity seen at the LOAEL of 100 mg/kg/day in the acute neurotoxicity study (NOAEL = 20 mg/kg/day).  A composite uncertainty factor of 100 to account for interspecies extrapolation and intraspecies variability is applied to the NOAEL to derive an aPAD of 0.2 mg/kg/day.  To estimate acute dietary exposure to females of childbearing age, an oral POD was selected based on increased post-implantation loss and fetal/litter resorptions seen at the LOAEL of 50 mg/kg/day in the rat developmental toxicity study (NOAEL = 12 mg/kg/day).  A composite uncertainty factor of 100 to account for interspecies extrapolation and intraspecies variability is applied to the NOAEL to derive an aPAD of 0.12 mg/kg/day.

To estimate chronic dietary exposure to the general U.S. population and all population subgroups, an oral POD was selected based on hematological effects (increased met- and sulf-hemoglobin levels) seen at the LOAEL of 3.5 mg/kg/day in the chronic dog toxicity study (NOAEL = 0.77 mg/kg/day).  A composite uncertainty factor of 100 to account for interspecies extrapolation and intraspecies variability is applied to the NOAEL to derive a cPAD of 0.0077 mg/kg/day.

The linuron risk assessment team evaluated the quality of the toxicity and exposure data and, based on these data, recommended that the Food Quality Protection Act (FQPA) Safety Factor be reduced to 1X.

Based on the weight of evidence of the available scientific data, linuron is classified as a "Group C Carcinogen" and quantification of human cancer risk is not required.

The toxicity endpoints pertinent for human dietary risk assessment are summarized in Table 4.

Table 4.    Summary of Toxicological Doses and Endpoints for Linuron for Use in Dietary Human Health Risk Assessments.
Exposure/
Scenario
                              Point of Departure
                        Uncertainty/FQPA Safety Factors
                RfD, PAD, Level of Concern for Risk Assessment
                        Study and Toxicological Effects
Acute Dietary (Females 13-49)
                              NOAEL= 12 mg/kg/day
                                  UFA  = 10x
                                   UFH = 10x
                                0.12 mg/kg/day
                        Rat Developmental Toxicity/ rat
LOAEL = 50 mg/kg/day  based on increased post-implantation loss and fetal/litter resorptions
Acute Dietary (All other populations)
                              NOAEL=20 mg/kg/day
                                  UFA  = 10x
                                   UFH = 10x
                                0.2 mg/kg/day
                        Acute neurotoxicity study/rat.
        LOAEL = 100 based on decreases in rearing and in motor activity
Chronic Dietary (All Populations)
                            NOAEL = 0.77 mg/kg/day
                                  UFA  = 10x
                                   UFH = 10x
                               0.0077 mg/kg/day
                              Chronic Oral / Dog
LOAEL = 3.5 mg/kg/day based on hematological effects (increased met- and sulfhemoglobin levels)
Cancer (oral, dermal, inhalation)
Classification: Group C Carcinogen requiring no quantification of human cancer risk (HIARC, 2001).
Abbreviations:  UF = uncertainty factor, UFA = extrapolation from animal to human (interspecies), UFH = potential variation in sensitivity among members of the human population (intraspecies), UFFQPA = FQPA Safety Factor, NOAEL = no-observed adverse-effect level, LOAEL = lowest-observed adverse-effect level, RfD = reference dose (a = acute, c = chronic), PAD = population-adjusted dose, LOC = level of concern.

VII.  Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in Tables 5 and 6 are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years.

Results of Acute Dietary (Food and Drinking Water) Exposure and Risk Analysis: The results of the acute dietary exposure and risk analysis at the 95[th], 99[th], and 99.9[th] percentile of exposure are reported in Table 5.

Table 5.  Results of Acute Dietary (Food and Drinking Water) Exposure and Risk Analysis for Linuron.
                              Population Subgroup
                                aPAD (mg/kg/day)
                               95[th] Percentile
                               99[th] Percentile
                              99.9[th] Percentile

                              Exposure (mg/kg/day)
                                     % aPAD
                              Exposure (mg/kg/day)
                                     % aPAD
                              Exposure (mg/kg/day)
                                   %     aPAD
 General U.S. Population
                                      0.2
                                    0.008608
                                      4.3
                                    0.014981
                                      7.5
                                    0.033031
                                       16
 All Infants (<1 year old)

                                    0.020664
                                       10
                                    0.030699
                                       15
                                    0.048768
                                       24
 Children 1-2 years old*

                                    0.016763
                                      8.4
                                    0.037965
                                       19
                                    0.101430
                                       51
 Children 3-5 years old

                                    0.013572
                                      6.8
                                    0.022049
                                       11
                                    0.048202
                                       24
 Children 6-12 years old

                                    0.008917
                                      4.5
                                    0.013911
                                      7.0
                                    0.033597
                                       17
 Youth 13-19 years old

                                    0.006169
                                      3.1
                                    0.009623
                                      4.8
                                    0.016348
                                      8.2
 Adults 20-49 years old

                                    0.006982
                                      3.5
                                    0.011212
                                      5.6
                                    0.019233
                                      9.6
 Adults 50-99 years old

                                    0.006621
                                      3.3
                                    0.012207
                                      6.1
                                    0.027922
                                       14
 Females 13-49 years old
                                      0.12
                                    0.006852
                                      5.7
                                    0.010797
                                      9.0
                                    0.018563
                                       15
*The subpopulation with the highest exposure & risk estimates.

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis: The results of the chronic dietary exposure analysis are reported in Table 6.

 Table 6.  Summary of Dietary (Food and Drinking Water) Exposure and Risk for Linuron.
                              Population Subgroup
                                 Acute Dietary
                              (95[th] Percentile)
                                Chronic Dietary

                          Dietary Exposure (mg/kg/day)
                                    % aPAD*
                                Dietary Exposure
                                  (mg/kg/day)
                                    % cPAD*
 General U.S. Population
                                    0.008608
                                      4.3
                                    0.001693
                                       22
 All Infants (<1 year old)
                                    0.020664
                                       10
                                    0.004301
                                       56
 Children 1-2 years old*
                                    0.016763
                                      8.4
                                    0.004592
                                       60
 Children 3-5 years old
                                    0.013572
                                      6.8
                                    0.003123
                                       41
 Children 6-12 years old
                                    0.008917
                                      4.5
                                    0.001985
                                       26
 Youth 13-19 years old
                                    0.006169
                                      3.1
                                    0.001264
                                       16
 Adults 20-49 years old
                                    0.006982
                                      3.5
                                    0.001469
                                       19
 Adults 50-99 years old
                                    0.006621
                                      3.3
                                    0.001464
                                       19
 Females 13-49 years old
                                    0.006852
                                      5.7
                                    0.001446
                                       19
*The subpopulation(s) with the highest exposure & risk estimates.

 VIII.  Characterization of Inputs/Outputs

The linuron dietary exposure risk estimates are mostly unrefined and considered conservative since they: (1) assume that 100% of the proposed crops were treated with linuron; (2) use established or recommended tolerance-level residues for all crops; (3) use default/conservative processing factors for processed commodities; and (4) use conservative, modeled drinking water estimates.  The tolerances are derived from crop field trials or conservative data translations and default processing factors.  The field trials were conducted at maximum application rates and minimum pre-harvest intervals.  Additional refinements to the assessment could include use of %CT information for proposed crops and any available monitoring data.  However, at this time, the dietary risks (food and water) of linuron are <10% of the aPAD and <60% of the cPAD and are not of concern to HED; therefore no further refinement is required.

 IX.  Conclusions

 A conservative dietary (food and drinking water) exposure and risk assessment was performed for linuron.  The assumptions incorporated into the assessment included 100% CT for the proposed commodities, estimated %CT assumptions or assumed 100% CT for some registered commodities, default processing factors, established/proposed tolerance level residues, and conservative EDWCs.  The acute dietary (food and drinking water) exposure estimates are below HED's level of concern (<100% aPAD) for all population subgroups at the 95[th] percentile of exposure.  The chronic dietary (food and drinking water) exposure estimates are also below HED's level of concern (<100% cPAD) for the general U.S. population and all population subgroups.  Linuron acute dietary (food and drinking water) risk utilized 5.8% of the aPAD for females 13-49 years old, 4.3% of the aPAD for the general U.S. population, and 10% of the aPAD for all infants, the most highly exposed population subgroup at the 95[th] percentile of exposure.  Linuron chronic dietary risk utilized 22% of the cPAD for the general U.S. population and 60% of the cPAD for children 1-2 years old, the most highly exposed population subgroup.  HED is confident that the assessment does not underestimate risk to the general U.S. population or any population subgroup.

 X.  List of Attachments
   1. Acute Residue Input File
   2. Chronic Residue Input File
   3. Acute Results File
   4. Chronic Results File
   5. Linuron SLUA

 Attachment 1: Acute Residue Input File

Filename: C:\Documents and Settings\krury\My Documents\My Work Files\Linuron\Linuron Coriander Dried Peas Horseradish Dill\Dietary\Linuron tolerance residue file acute revised 120413.r08
Chemical: linuron
RfD(Chronic): .0077 mg/kg bw/day  NOEL(Chronic): .77 mg/kg bw/day
RfD(Acute): .2 mg/kg bw/day  NOEL(Acute):  20 mg/kg bw/day
Date created/last modified: 12-04-2013/12:31:15       Program ver. 3.16, 03-08-d
Comment: Females 13-49 POD is 12 mg/kg/day
-----------------------------------------------------------------------------------
   EPA     Crop                                   Def Res     Adj.Factors   Comment
   Code     Grp  Commodity Name                    (ppm)       #1    #2
---------- ---- -------------------------------  ----------  ------ ------  -------
0101078000 1AB  Carrot                             1.000000   1.000  1.000
0101078001 1AB  Carrot-babyfood                    1.000000   1.000  1.000
0101079000 1AB  Carrot, juice                      1.000000   1.000  1.000
0101084000 1AB  Celeriac                           1.000000   1.000  1.000
0101190000 1AB  Horseradish                        0.050000   1.000  1.000
0101251000 1AB  Parsnip                            0.050000   1.000  1.000
0101251001 1AB  Parsnip-babyfood                   0.050000   1.000  1.000
0103296000 1C   Potato, chips                      0.200000   1.000  1.000
0103297000 1C   Potato, dry (granules/ flakes)     0.200000   6.500  1.000
0103297001 1C   Potato, dry (granules/ flakes)-b   0.200000   6.500  1.000
0103298000 1C   Potato, flour                      0.200000   6.500  1.000
0103298001 1C   Potato, flour-babyfood             0.200000   6.500  1.000
0103299000 1C   Potato, tuber, w/peel              0.200000   1.000  1.000
0103299001 1C   Potato, tuber, w/peel-babyfood     0.200000   1.000  1.000
0103300000 1C   Potato, tuber, w/o peel            0.200000   1.000  1.000
0103300001 1C   Potato, tuber, w/o peel-babyfood   0.200000   1.000  1.000
0401248000 4A   Parsley, leaves
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   0.090000   1.000  1.000
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   0.090000   1.000  1.000
                   211-Cooked; Fresh or N/S; Baked
                                                   0.090000   1.000  1.000
                   212-Cooked; Fresh or N/S; Boiled
                                                   0.090000   1.000  1.000
                   213-Cooked; Fresh or N/S; Fried
                                                   0.090000   1.000  1.000
                   215-Cooked; Fresh or N/S; Boiled/baked
                                                   0.090000   1.000  1.000
                   221-Cooked; Frozen; Baked       0.090000   1.000  1.000
                   232-Cooked; Dried; Boiled       9.000000   1.000  1.000
                   240-Cooked; Canned; Cook Meth N/S
                                                   0.090000   1.000  1.000
                   242-Cooked; Canned; Boiled      0.090000   1.000  1.000
0402085000 4B   Celery                             0.500000   1.000  1.000
0402085001 4B   Celery-babyfood                    0.500000   1.000  1.000
0402086000 4B   Celery, juice                      0.500000   1.000  1.000
0402152000 4B   Fennel, Florence                   0.500000   1.000  1.000
0402322000 4B   Rhubarb                            0.500000   1.000  1.000
0600347000 6    Soybean, seed                      1.000000   1.000  1.000
0600349000 6    Soybean, soy milk                  1.000000   1.000  1.000
0600349001 6    Soybean, soy milk-babyfood or in   1.000000   1.000  1.000
0600350000 6    Soybean, oil                       1.000000   1.000  1.000
0600350001 6    Soybean, oil-babyfood              1.000000   1.000  1.000
0601257000 6A   Pea, edible podded, succulent
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   0.090000   1.000  1.000
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   0.090000   1.000  1.000
                   212-Cooked; Fresh or N/S; Boiled
                                                   0.090000   1.000  1.000
                   213-Cooked; Fresh or N/S; Fried
                                                   0.090000   1.000  1.000
                   220-Cooked; Frozen; Cook Meth N/S
                                                   0.090000   1.000  1.000
                   221-Cooked; Frozen; Baked       0.090000   1.000  1.000
0601349500 6AB  Soybean, vegetable                 1.000000   1.000  1.000
0602259000 6B   Pea, pigeon, succulent             0.090000   1.000  1.000
0603098000 6C   Chickpea, seed
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   212-Cooked; Fresh or N/S; Boiled
                                                   0.000000   1.000  1.000
                   232-Cooked; Dried; Boiled       0.090000   1.000  1.000
                   234-Cooked; Dried; Fried/baked  0.090000   1.000  1.000
0603098001 6C   Chickpea, seed-babyfood
                   240-Cooked; Canned; Cook Meth N/S
                                                   0.090000   1.000  1.000
0603099000 6C   Chickpea, flour                    0.090000   1.000  1.000
0603182000 6C   Guar, seed
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   120-Uncooked; Frozen; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   130-Uncooked; Dried; Cook Meth N/S
                                                   0.090000   1.000  1.000
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   211-Cooked; Fresh or N/S; Baked
                                                   0.000000   1.000  1.000
                   212-Cooked; Fresh or N/S; Boiled
                                                   0.000000   1.000  1.000
                   213-Cooked; Fresh or N/S; Fried
                                                   0.000000   1.000  1.000
                   214-Cooked; Fresh or N/S; Fried/baked
                                                   0.000000   1.000  1.000
                   221-Cooked; Frozen; Baked       0.000000   1.000  1.000
                   223-Cooked; Frozen; Fried       0.000000   1.000  1.000
                   230-Cooked; Dried; Cook Meth N/S
                                                   0.090000   1.000  1.000
                   240-Cooked; Canned; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   250-Cooked; Cured etc; Cook Meth N/S
                                                   0.000000   1.000  1.000
0603182001 6C   Guar, seed-babyfood                0.090000   1.000  1.000
0603203000 6C   Lentil, seed
                   230-Cooked; Dried; Cook Meth N/S
                                                   0.100000   1.000  1.000
                   232-Cooked; Dried; Boiled       0.100000   1.000  1.000
0603256000 6C   Pea, dry                           0.090000   1.000  1.000
0603256001 6C   Pea, dry-babyfood                  0.090000   1.000  1.000
0603258000 6C   Pea, pigeon, seed
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   232-Cooked; Dried; Boiled       0.090000   1.000  1.000
0603348000 6C   Soybean, flour                     1.000000   1.000  1.000
0603348001 6C   Soybean, flour-babyfood            1.000000   1.000  1.000
1500120000 15   Corn, field, flour                 0.100000   1.000  1.000
1500120001 15   Corn, field, flour-babyfood        0.100000   1.000  1.000
1500121000 15   Corn, field, meal                  0.100000   1.000  1.000
1500121001 15   Corn, field, meal-babyfood         0.100000   1.000  1.000
1500122000 15   Corn, field, bran                  0.100000   1.000  1.000
1500123000 15   Corn, field, starch                0.100000   1.000  1.000
1500123001 15   Corn, field, starch-babyfood       0.100000   1.000  1.000
1500124000 15   Corn, field, syrup                 0.100000   1.500  1.000
1500124001 15   Corn, field, syrup-babyfood        0.100000   1.500  1.000
1500125000 15   Corn, field, oil                   0.100000   1.000  1.000
1500125001 15   Corn, field, oil-babyfood          0.100000   1.000  1.000
1500127000 15   Corn, sweet                        0.250000   1.000  1.000
1500127001 15   Corn, sweet-babyfood               0.250000   1.000  1.000
1500344000 15   Sorghum, grain                     0.250000   1.000  1.000
1500345000 15   Sorghum, syrup                     0.250000   1.000  1.000
1500381000 15   Triticale, flour                   0.050000   1.000  1.000
1500381001 15   Triticale, flour-babyfood          0.050000   1.000  1.000
1500401000 15   Wheat, grain                       0.050000   1.000  1.000
1500401001 15   Wheat, grain-babyfood              0.050000   1.000  1.000
1500402000 15   Wheat, flour                       0.050000   1.000  1.000
1500402001 15   Wheat, flour-babyfood              0.050000   1.000  1.000
1500403000 15   Wheat, germ                        0.050000   1.000  1.000
1500404000 15   Wheat, bran                        0.050000   1.000  1.000
1901118000 19A  Cilantro, leaves
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   3.000000   1.000  1.000
                   150-Uncooked; Cured etc; Cook Meth N/S
                                                   3.000000   1.000  1.000
                   204-Cooked; FF N/A; Fried/baked
                                                   3.000000   1.000  1.000
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   3.000000   1.000  1.000
                   211-Cooked; Fresh or N/S; Baked
                                                   3.000000   1.000  1.000
                   212-Cooked; Fresh or N/S; Boiled
                                                   3.000000   1.000  1.000
                   213-Cooked; Fresh or N/S; Fried
                                                   3.000000   1.000  1.000
                   214-Cooked; Fresh or N/S; Fried/baked
                                                   3.000000   1.000  1.000
                   221-Cooked; Frozen; Baked       3.000000   1.000  1.000
                   230-Cooked; Dried; Cook Meth N/S
                                                  10.000000   1.000  1.000
                   232-Cooked; Dried; Boiled      10.000000   1.000  1.000
                   240-Cooked; Canned; Cook Meth N/S
                                                   3.000000   1.000  1.000
                   242-Cooked; Canned; Boiled      3.000000   1.000  1.000
                   250-Cooked; Cured etc; Cook Meth N/S
                                                   3.000000   1.000  1.000
                   252-Cooked; Cured etc; Boiled   3.000000   1.000  1.000
1901118001 19A  Cilantro, leaves-babyfood          3.000000   1.000  1.000
1901144000 19A  Dillweed
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   1.500000   1.000  1.000
                   150-Uncooked; Cured etc; Cook Meth N/S
                                                   1.500000   1.000  1.000
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   5.000000   1.000  1.000
                   211-Cooked; Fresh or N/S; Baked
                                                   5.000000   1.000  1.000
                   212-Cooked; Fresh or N/S; Boiled
                                                   5.000000   1.000  1.000
                   240-Cooked; Canned; Cook Meth N/S
                                                   5.000000   1.000  1.000
1901249000 19A  Parsley, dried leaves              9.000000   1.000  1.000
1901249001 19A  Parsley, dried leaves-babyfood     9.000000   1.000  1.000
1902119000 19B  Coriander, seed                    0.050000   1.000  1.000
1902119001 19B  Coriander, seed-babyfood           0.050000   1.000  1.000
1902143000 19B  Dill, seed                         0.500000   1.000  1.000
2003128000 20C  Cottonseed, oil                    0.250000   1.000  1.000
2003128001 20C  Cottonseed, oil-babyfood           0.250000   1.000  1.000
3100044000 31   Beef, meat                         0.100000   1.000  1.000
3100044001 31   Beef, meat-babyfood                0.100000   1.000  1.000
3100045000 31   Beef, meat, dried                  0.100000   1.920  1.000
3100046000 31   Beef, meat byproducts              2.000000   1.000  1.000  Set to
            Full comment: Set to highest non-meat tol level per chemsac
3100046001 31   Beef, meat byproducts-babyfood     2.000000   1.000  1.000  Set to
            Full comment: Set to highest non-meat tol level per chemsac
3100047000 31   Beef, fat                          0.200000   1.000  1.000
3100047001 31   Beef, fat-babyfood                 0.200000   1.000  1.000
3100048000 31   Beef, kidney                       2.000000   1.000  1.000
3100049000 31   Beef, liver                        2.000000   1.000  1.000
3100049001 31   Beef, liver-babyfood               2.000000   1.000  1.000
3200169000 32   Goat, meat                         0.100000   1.000  1.000
3200170000 32   Goat, meat byproducts              2.000000   1.000  1.000  Set to
            Full comment: Set to highest non-meat tol level per chemsac
3200171000 32   Goat, fat                          0.200000   1.000  1.000
3200172000 32   Goat, kidney                       2.000000   1.000  1.000
3200173000 32   Goat, liver                        2.000000   1.000  1.000
3300189000 33   Horse, meat                        0.100000   1.000  1.000
3400290000 34   Pork, meat                         0.050000   1.000  1.000
3400290001 34   Pork, meat-babyfood                0.050000   1.000  1.000
3400291000 34   Pork, skin                         0.100000   1.000  1.000
3400292000 34   Pork, meat byproducts              0.100000   1.000  1.000  Set to
            Full comment: Set to highest non-meat tol level per chemsac
3400292001 34   Pork, meat byproducts-babyfood     0.100000   1.000  1.000  Set to
            Full comment: Set to highest non-meat tol level per chemsac
3400293000 34   Pork, fat                          0.050000   1.000  1.000
3400293001 34   Pork, fat-babyfood                 0.050000   1.000  1.000
3400294000 34   Pork, kidney                       0.100000   1.000  1.000
3400295000 34   Pork, liver                        0.100000   1.000  1.000
3500339000 35   Sheep, meat                        0.100000   1.000  1.000
3500339001 35   Sheep, meat-babyfood               0.100000   1.000  1.000
3500340000 35   Sheep, meat byproducts             2.000000   1.000  1.000  Set to
            Full comment: Set to highest non-meat tol level per chemsac
3500341000 35   Sheep, fat                         0.200000   1.000  1.000
3500341001 35   Sheep, fat-babyfood                0.200000   1.000  1.000
3500342000 35   Sheep, kidney                      2.000000   1.000  1.000
3500343000 35   Sheep, liver                       2.000000   1.000  1.000
3600222000 36   Milk, fat                          0.050000   1.000  1.000
3600222001 36   Milk, fat-baby food/infant formu   0.050000   1.000  1.000
3600223000 36   Milk, nonfat solids                0.050000   1.000  1.000
3600223001 36   Milk, nonfat solids-baby food/in   0.050000   1.000  1.000
3600224000 36   Milk, water                        0.050000   1.000  1.000
3600224001 36   Milk, water-babyfood/infant form   0.050000   1.000  1.000
3600225001 36   Milk, sugar (lactose)-baby food/   0.050000   1.000  1.000
8601000000 86A  Water, direct, all sources         0.089050   1.000  1.000
8602000000 86B  Water, indirect, all sources       0.089050   1.000  1.000
9500019000 O    Asparagus                          7.000000   1.000  1.000

Attachment 2: Chronic Residue Input File

Filename: C:\Documents and Settings\krury\My Documents\My Work Files\Linuron\Linuron Coriander Dried Peas Horseradish Dill\Dietary\Linuron tolerance residue file chronic revised 120413.r08
Chemical: Linuron
RfD(Chronic): .0077 mg/kg bw/day  NOEL(Chronic): .77 mg/kg bw/day
RfD(Acute): .2 mg/kg bw/day  NOEL(Acute):  20 mg/kg bw/day
Date created/last modified: 12-13-2013/09:14:19       Program ver. 3.16, 03-08-d
-----------------------------------------------------------------------------------
   EPA     Crop                                   Def Res     Adj.Factors   Comment
   Code     Grp  Commodity Name                    (ppm)       #1    #2
---------- ---- -------------------------------  ----------  ------ ------  -------
0101078000 1AB  Carrot                             1.000000   1.000  0.850
0101078001 1AB  Carrot-babyfood                    1.000000   1.000  0.850
0101079000 1AB  Carrot, juice                      1.000000   1.000  0.850
0101084000 1AB  Celeriac                           1.000000   1.000  1.000
0101190000 1AB  Horseradish                        0.050000   1.000  1.000
0101251000 1AB  Parsnip                            0.050000   1.000  1.000
0101251001 1AB  Parsnip-babyfood                   0.050000   1.000  1.000
0103296000 1C   Potato, chips                      0.200000   1.000  0.050
0103297000 1C   Potato, dry (granules/ flakes)     0.200000   6.500  0.050
0103297001 1C   Potato, dry (granules/ flakes)-b   0.200000   6.500  0.050
0103298000 1C   Potato, flour                      0.200000   6.500  0.050
0103298001 1C   Potato, flour-babyfood             0.200000   6.500  0.050
0103299000 1C   Potato, tuber, w/peel              0.200000   1.000  0.050
0103299001 1C   Potato, tuber, w/peel-babyfood     0.200000   1.000  0.050
0103300000 1C   Potato, tuber, w/o peel            0.200000   1.000  0.050
0103300001 1C   Potato, tuber, w/o peel-babyfood   0.200000   1.000  0.050
0401248000 4A   Parsley, leaves
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   4.000000   1.000  0.050
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   4.000000   1.000  0.050
                   211-Cooked; Fresh or N/S; Baked
                                                   4.000000   1.000  0.050
                   212-Cooked; Fresh or N/S; Boiled
                                                   4.000000   1.000  0.050
                   213-Cooked; Fresh or N/S; Fried
                                                   4.000000   1.000  0.050
                   215-Cooked; Fresh or N/S; Boiled/baked
                                                   4.000000   1.000  0.050
                   221-Cooked; Frozen; Baked       4.000000   1.000  0.050
                   232-Cooked; Dried; Boiled       9.000000   1.000  0.050
                   240-Cooked; Canned; Cook Meth N/S
                                                   4.000000   1.000  0.050
                   242-Cooked; Canned; Boiled      4.000000   1.000  0.050
0402085000 4B   Celery                             0.500000   1.000  0.250
0402085001 4B   Celery-babyfood                    0.500000   1.000  0.250
0402086000 4B   Celery, juice                      0.500000   1.000  0.250
0402152000 4B   Fennel, Florence                   0.500000   1.000  1.000
0402322000 4B   Rhubarb                            0.500000   1.000  1.000
0600347000 6    Soybean, seed                      1.000000   1.000  0.010
0600349000 6    Soybean, soy milk                  1.000000   1.000  0.010
0600349001 6    Soybean, soy milk-babyfood or in   1.000000   1.000  0.010
0600350000 6    Soybean, oil                       1.000000   1.000  0.010
0600350001 6    Soybean, oil-babyfood              1.000000   1.000  0.010
0601349500 6AB  Soybean, vegetable                 1.000000   1.000  0.010
0602259000 6B   Pea, pigeon, succulent             0.090000   1.000  1.000
0603098000 6C   Chickpea, seed
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   212-Cooked; Fresh or N/S; Boiled
                                                   0.000000   1.000  1.000
                   232-Cooked; Dried; Boiled       0.090000   1.000  1.000
                   234-Cooked; Dried; Fried/baked  0.090000   1.000  1.000
0603098001 6C   Chickpea, seed-babyfood            0.090000   1.000  1.000
0603099000 6C   Chickpea, flour                    0.090000   1.000  1.000
0603182000 6C   Guar, seed
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   120-Uncooked; Frozen; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   130-Uncooked; Dried; Cook Meth N/S
                                                   0.090000   1.000  1.000
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   211-Cooked; Fresh or N/S; Baked
                                                   0.000000   1.000  1.000
                   212-Cooked; Fresh or N/S; Boiled
                                                   0.000000   1.000  1.000
                   213-Cooked; Fresh or N/S; Fried
                                                   0.000000   1.000  1.000
                   214-Cooked; Fresh or N/S; Fried/baked
                                                   0.000000   1.000  1.000
                   221-Cooked; Frozen; Baked       0.000000   1.000  1.000
                   223-Cooked; Frozen; Fried       0.000000   1.000  1.000
                   230-Cooked; Dried; Cook Meth N/S
                                                   0.090000   1.000  1.000
                   240-Cooked; Canned; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   250-Cooked; Cured etc; Cook Meth N/S
                                                   0.000000   1.000  1.000
0603182001 6C   Guar, seed-babyfood                0.090000   1.000  1.000
0603203000 6C   Lentil, seed                       0.100000   1.000  1.000
0603256000 6C   Pea, dry                           0.080000   1.000  1.000
0603256001 6C   Pea, dry-babyfood                  0.080000   1.000  1.000
0603258000 6C   Pea, pigeon, seed
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   0.000000   1.000  1.000
                   232-Cooked; Dried; Boiled       0.100000   1.000  1.000
0603348000 6C   Soybean, flour                     1.000000   1.000  0.010
0603348001 6C   Soybean, flour-babyfood            1.000000   1.000  0.010
1500120000 15   Corn, field, flour                 0.100000   1.000  0.010
1500120001 15   Corn, field, flour-babyfood        0.100000   1.000  0.010
1500121000 15   Corn, field, meal                  0.100000   1.000  0.010
1500121001 15   Corn, field, meal-babyfood         0.100000   1.000  0.010
1500122000 15   Corn, field, bran                  0.100000   1.000  0.010
1500123000 15   Corn, field, starch                0.100000   1.000  0.010
1500123001 15   Corn, field, starch-babyfood       0.100000   1.000  0.010
1500124000 15   Corn, field, syrup                 0.100000   1.500  0.010
1500124001 15   Corn, field, syrup-babyfood        0.100000   1.500  0.010
1500125000 15   Corn, field, oil                   0.100000   1.000  0.010
1500125001 15   Corn, field, oil-babyfood          0.100000   1.000  0.010
1500127000 15   Corn, sweet                        0.250000   1.000  0.010
1500127001 15   Corn, sweet-babyfood               0.250000   1.000  0.010
1500344000 15   Sorghum, grain                     0.250000   1.000  0.010
1500345000 15   Sorghum, syrup                     0.250000   1.000  0.010
1500381000 15   Triticale, flour                   0.050000   1.000  1.000
1500381001 15   Triticale, flour-babyfood          0.050000   1.000  1.000
1500401000 15   Wheat, grain                       0.050000   1.000  0.010
1500401001 15   Wheat, grain-babyfood              0.050000   1.000  0.010
1500402000 15   Wheat, flour                       0.050000   1.000  0.010
1500402001 15   Wheat, flour-babyfood              0.050000   1.000  0.010
1500403000 15   Wheat, germ                        0.050000   1.000  0.010
1500404000 15   Wheat, bran                        0.050000   1.000  0.010
1901118000 19A  Cilantro, leaves
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   3.000000   1.000  1.000
                   150-Uncooked; Cured etc; Cook Meth N/S
                                                   3.000000   1.000  1.000
                   204-Cooked; FF N/A; Fried/baked
                                                   3.000000   1.000  1.000
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   3.000000   1.000  1.000
                   211-Cooked; Fresh or N/S; Baked
                                                   3.000000   1.000  1.000
                   212-Cooked; Fresh or N/S; Boiled
                                                   3.000000   1.000  1.000
                   213-Cooked; Fresh or N/S; Fried
                                                   3.000000   1.000  1.000
                   214-Cooked; Fresh or N/S; Fried/baked
                                                   3.000000   1.000  1.000
                   221-Cooked; Frozen; Baked       3.000000   1.000  1.000
                   230-Cooked; Dried; Cook Meth N/S
                                                  10.000000   1.000  1.000
                   232-Cooked; Dried; Boiled      10.000000   1.000  1.000
                   240-Cooked; Canned; Cook Meth N/S
                                                   3.000000   1.000  1.000
                   242-Cooked; Canned; Boiled      3.000000   1.000  1.000
                   250-Cooked; Cured etc; Cook Meth N/S
                                                   3.000000   1.000  1.000
                   252-Cooked; Cured etc; Boiled   3.000000   1.000  1.000
1901118001 19A  Cilantro, leaves-babyfood          3.000000   1.000  1.000
1901144000 19A  Dillweed
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   1.500000   1.000  1.000
                   150-Uncooked; Cured etc; Cook Meth N/S
                                                   1.500000   1.000  1.000
                   210-Cooked; Fresh or N/S; Cook Meth N/S
                                                   5.000000   1.000  1.000
                   211-Cooked; Fresh or N/S; Baked
                                                   5.000000   1.000  1.000
                   212-Cooked; Fresh or N/S; Boiled
                                                   5.000000   1.000  1.000
                   240-Cooked; Canned; Cook Meth N/S
                                                   5.000000   1.000  1.000
1901249000 19A  Parsley, dried leaves              9.000000   1.000  1.000
1901249001 19A  Parsley, dried leaves-babyfood     9.000000   1.000  1.000
1902119000 19B  Coriander, seed                    0.050000   1.000  1.000
1902119001 19B  Coriander, seed-babyfood           0.050000   1.000  1.000
1902143000 19B  Dill, seed                         0.500000   1.000  1.000
2003128000 20C  Cottonseed, oil                    0.250000   1.000  0.010
2003128001 20C  Cottonseed, oil-babyfood           0.250000   1.000  0.010
3100044000 31   Beef, meat                         0.100000   1.000  1.000
3100044001 31   Beef, meat-babyfood                0.100000   1.000  1.000
3100045000 31   Beef, meat, dried                  0.100000   1.920  1.000
3100046000 31   Beef, meat byproducts              2.000000   1.000  1.000  Set to
            Full comment: Set to highest byp tol per ChemSAC
3100046001 31   Beef, meat byproducts-babyfood     2.000000   1.000  1.000  Set to
            Full comment: Set to highest byp tol per ChemSAC
3100047000 31   Beef, fat                          0.200000   1.000  1.000
3100047001 31   Beef, fat-babyfood                 0.200000   1.000  1.000
3100048000 31   Beef, kidney                       2.000000   1.000  1.000
3100049000 31   Beef, liver                        2.000000   1.000  1.000
3100049001 31   Beef, liver-babyfood               2.000000   1.000  1.000
3200169000 32   Goat, meat                         0.100000   1.000  1.000
3200170000 32   Goat, meat byproducts              2.000000   1.000  1.000  Set to
            Full comment: Set to highest byp tol per ChemSAC
3200171000 32   Goat, fat                          0.200000   1.000  1.000
3200172000 32   Goat, kidney                       2.000000   1.000  1.000
3200173000 32   Goat, liver                        2.000000   1.000  1.000
3300189000 33   Horse, meat                        0.100000   1.000  1.000
3400290000 34   Pork, meat                         0.050000   1.000  1.000
3400290001 34   Pork, meat-babyfood                0.050000   1.000  1.000
3400291000 34   Pork, skin                         0.100000   1.000  1.000
3400292000 34   Pork, meat byproducts              0.100000   1.000  1.000  Set to
            Full comment: Set to highest byp tol per ChemSAC
3400292001 34   Pork, meat byproducts-babyfood     0.100000   1.000  1.000  Set to
            Full comment: Set to highest byp tol per ChemSAC
3400293000 34   Pork, fat                          0.050000   1.000  1.000
3400293001 34   Pork, fat-babyfood                 0.050000   1.000  1.000
3400294000 34   Pork, kidney                       0.100000   1.000  1.000
3400295000 34   Pork, liver                        0.100000   1.000  1.000
3500339000 35   Sheep, meat                        0.100000   1.000  1.000
3500339001 35   Sheep, meat-babyfood               0.100000   1.000  1.000
3500340000 35   Sheep, meat byproducts             2.000000   1.000  1.000  Set to
            Full comment: Set to highest byp tol per ChemSAC
3500341000 35   Sheep, fat                         0.200000   1.000  1.000
3500341001 35   Sheep, fat-babyfood                0.200000   1.000  1.000
3500342000 35   Sheep, kidney                      2.000000   1.000  1.000
3500343000 35   Sheep, liver                       2.000000   1.000  1.000
3600222000 36   Milk, fat                          0.050000   1.000  1.000
3600222001 36   Milk, fat-baby food/infant formu   0.050000   1.000  1.000
3600223000 36   Milk, nonfat solids                0.050000   1.000  1.000
3600223001 36   Milk, nonfat solids-baby food/in   0.050000   1.000  1.000
3600224000 36   Milk, water                        0.050000   1.000  1.000
3600224001 36   Milk, water-babyfood/infant form   0.050000   1.000  1.000
3600225001 36   Milk, sugar (lactose)-baby food/   0.050000   1.000  1.000
8601000000 86A  Water, direct, all sources         0.048800   1.000  1.000
8602000000 86B  Water, indirect, all sources       0.048800   1.000  1.000
9500019000 O    Asparagus                          7.000000   1.000  0.250

Attachment 3: Acute Results

U.S. EPA                                                    Ver. 3.16, 03-08-d
DEEM-FCID ACUTE Analysis for LINURON                     NHANES 2003-2008 2-Day
Residue file: Linuron tolerance residue file acute revised 120413.r08
Adjustment factor #2 NOT used.
Analysis Date: 12-13-2013/09:12:38    Residue file dated: 12-13-2013/09:10:48
NOEL (Acute) =  20.000000 mg/kg body-wt/day
Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports
RAC/FF intake summed over 24 hours
Run Comment: "Females 13-49 POD is 12 mg/kg/day"
===============================================================================

Summary calculations--per capita:

---   95th Percentile----   ---   99th Percentile----     ---99.9th Percentile----
 Exposure  % aPAD     MOE    Exposure  % aPAD     MOE    Exposure  % aPAD     MOE
---------- ------- -------- ---------- ------- -------- ---------- ------- --------
Total US Population:
  0.008608    4.30    2323    0.014981    7.49    1335    0.033031   16.52     605
All Infants:
  0.020664   10.33     967    0.030699   15.35     651    0.048768   24.38     410
Children 1-2:
  0.016763    8.38    1193    0.037965   18.98     526    0.101430   50.71     197
Children 3-5:
  0.013572    6.79    1473    0.022049   11.02     907    0.048202   24.10     414
Children 6-12:
  0.008917    4.46    2242    0.013911    6.96    1437    0.033597   16.80     595
Youth 13-19:
  0.006169    3.08    3241    0.009623    4.81    2078    0.016348    8.17    1223
Adults 20-49:
  0.006982    3.49    2864    0.011212    5.61    1783    0.019233    9.62    1039
Adults 50-99:
  0.006621    3.31    3020    0.012207    6.10    1638    0.027922   13.96     716
Female 13-49:
  0.006852    5.71    2918    0.010797    9.00    1852    0.018563   15.47    1077
Attachment 4: Chronic Results  -  General U.S. Population

U.S. EPA                                                        Ver. 3.16, 03-08-d
DEEM-FCID Chronic analysis for LINURON                     NHANES 2003-2008 2-day
Residue file name: C:\Documents and Settings\krury\My Documents\My Work Files\Linuron\Linuron Coriander Dried Peas Horseradish Dill\Dietary\Linuron tolerance residue file chronic revised 120413.r08
                                                     Adjustment factor #2 used.
Analysis Date 12-13-2013/09:15:31     Residue file dated: 12-13-2013/09:14:19
Reference dose (RfD, Chronic) = .0077 mg/kg bw/day
===============================================================================
                    Total exposure by population subgroup
-------------------------------------------------------------------------------

                                                    Total Exposure
                                         -----------------------------------
          Population                         mg/kg             Percent of
           Subgroup                       body wt/day             Rfd
--------------------------------------   -------------       ----------------
Total US Population                         0.001693                22.0%
Hispanic                                    0.001759                22.8%
Non-Hisp-White                              0.001716                22.3%
Non-Hisp-Black                              0.001386                18.0%
Non-Hisp-Other                              0.001946                25.3%
Nursing Infants                             0.001912                24.8%
Non-Nursing Infants                         0.005368                69.7%
Female 13+ PREG                             0.001446                18.8%
Children 1-6                                0.003568                46.3%
Children 7-12                               0.001865                24.2%
Male 13-19                                  0.001289                16.7%
Female 13-19/NP                             0.001240                16.1%
Male 20+                                    0.001415                18.4%
Female 20+/NP                               0.001514                19.7%
Seniors 55+                                 0.001458                18.9%
All Infants                                 0.004301                55.9%
Female 13-50                                0.001446                18.8%
Children 1-2                                0.004592                59.6%
Children 3-5                                0.003123                40.6%
Children 6-12                               0.001985                25.8%
Youth 13-19                                 0.001264                16.4%
Adults 20-49                                0.001469                19.1%
Adults 50-99                                0.001464                19.0%
Female 13-49                                0.001446                18.8%

-------------------------------------------------------------------------------

Attachment 5: SLUA Provided by BEAD


[Federal Register Volume 79, Number 246 (Tuesday, December 23, 2014)]
[Notices]
[Pages 76999-77000]
[FR Doc No: 2014-29952]

-----------------------------------------------------------------------

DEPARTMENT OF ENERGY

Federal Energy Regulatory Commission

[Project No., 14652-000]

BC Energy, LLC; Notice of Preliminary Permit Application Accepted
for Filing and Soliciting Comments, Motions To Intervene, and Competing
Applications

    On December 10, 2014, BC Energy, LLC, filed an application for a
preliminary permit, pursuant to section 4(f) of the Federal Power Act
(FPA), proposing to study the feasibility of the Bruskasna Creek
Hydroelectric Project (Bruskasna Creek Project or project) to be
located on Bruskasna Creek, in unincorporated Denali Borough, Alaska.
The sole purpose of a preliminary permit, if issued, is to grant the
permit holder priority to file a license application during the permit
term. A preliminary permit does not authorize the permit holder to
perform any land-disturbing activities or otherwise enter upon lands or
waters owned by others without the owners' express permission.
    The proposed project would consist of the following new features:
(1) A 50-foot-long, 10-foot-high concrete diversion weir traversing
Bruskasna Creek; (2) an approximately 10-acre-foot impoundment; (3) a
13,500-foot-long, 2.5-foot-diameter steel penstock; (4) a 25-foot-long,
35-foot-wide concrete powerhouse; (5) a single 1.7-megawatt Pelton
turbine/generator; (6) a 34,000-foot-long, 15-kilovolt (kV)
transmission line interconnecting with an existing 15-kV Golden Valley
Electric Association distribution line; (7) an approximately 46,000-
foot-long access road; and (8) appurtenant facilities. The estimated
annual generation of the Bruskasna Creek Project would be 5.2 gigawatt-
hours.
    Applicant Contact: Mr. Brent Smith, Northwest Power Services, Inc.,
P.O. Box 872316, Wasilla, Alaska 99687; phone:<PHONE_NUMBER>.
    FERC Contact: Sean O'Neill; phone:<PHONE_NUMBER>.
    Deadline for filing comments, motions to intervene, competing
applications (without notices of intent), or notices of intent to file
competing applications: 60 days from the issuance of this notice.
Competing applications and notices of intent must meet the requirements
of 18 CFR 4.36.
    The Commission strongly encourages electronic filing. Please file
comments, motions to intervene, notices of intent, and competing
applications using the Commission's eFiling system at http://www.ferc.gov/docs-filing/efiling.asp. Commenters can submit brief
comments

up to 6,000 characters, without prior registration, using the eComment
system at http://www.ferc.gov/docs-filing/ecomment.asp. You must
include your name and contact information at the end of your comments.
For assistance, please contact FERC Online Support at
<EMAIL_ADDRESS>(866) 208-3676 (toll free), or (202) 502-
8659 (TTY). In lieu of electronic filing, please send a paper copy to:
Secretary, Federal Energy Regulatory Commission, 888 First Street NE.,
Washington, DC 20426. The first page of any filing should include
docket number P-14652-000.
    More information about this project, including a copy of the
application, can be viewed or printed on the ``eLibrary'' link of
Commission's Web site at http://www.ferc.gov/docs-filing/elibrary.asp.
Enter the docket number (P-14652) in the docket number field to access
the document. For assistance, contact FERC Online Support.

    Dated: December 16, 2014.
 Kimberly D. Bose,
 Secretary.
[FR Doc. 2014-29952 Filed 12-22-14; 8:45 am]
BILLING CODE 6717-01-P


[Federal Register Volume 83, Number 182 (Wednesday, September 19, 2018)]
[Notices]
[Page 47348]
[FR Doc No: 2018-20319]

-----------------------------------------------------------------------

DEPARTMENT OF HOMELAND SECURITY

Federal Emergency Management Agency

[Internal Agency Docket No. FEMA-4353-DR; Docket ID FEMA-2018-0001]

California; Amendment No. 4 to Notice of a Major Disaster
Declaration

AGENCY: Federal Emergency Management Agency, DHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: This notice amends the notice of a major disaster declaration
for the State of California (FEMA-4353-DR), dated January 2, 2018, and
related determinations.

DATES: This amendment was issued September 7, 2018.

FOR FURTHER INFORMATION CONTACT: Dean Webster, Office of Response and
Recovery, Federal Emergency Management Agency, 500 C Street SW,
Washington, DC 20472,<PHONE_NUMBER>.

SUPPLEMENTARY INFORMATION: Notice is hereby given that the incident
period for this disaster is closed effective January 31, 2018.

    The following Catalog of Federal Domestic Assistance Numbers
(CFDA) are to be used for reporting and drawing funds: 97.030,
Community Disaster Loans; 97.031, Cora Brown Fund; 97.032, Crisis
Counseling; 97.033, Disaster Legal Services; 97.034, Disaster
Unemployment Assistance (DUA); 97.046, Fire Management Assistance
Grant; 97.048, Disaster Housing Assistance to Individuals and
Households In Presidentially Declared Disaster Areas; 97.049,
Presidentially Declared Disaster Assistance--Disaster Housing
Operations for Individuals and Households; 97.050, Presidentially
Declared Disaster Assistance to Individuals and Households--Other
Needs; 97.036, Disaster Grants--Public Assistance (Presidentially
Declared Disasters); 97.039, Hazard Mitigation Grant.

Brock Long,
Administrator, Federal Emergency Management Agency.
[FR Doc. 2018-20319 Filed 9-18-18; 8:45 am]
 BILLING CODE 9111-11-P


EPA REGISTRATION DIVISION COMPANY NOTICE OF FILING FOR PESTICIDE PETITIONS PUBLISHED IN THE FEDERAL REGISTER

EPA Registration Division contact: [Kathryn Montague,<PHONE_NUMBER>]

INSTRUCTIONS:  Please utilize this outline in preparing the pesticide petition.  In cases where the outline element does not apply, please insert "NA-Remove" and maintain the outline. Please do not change the margins, font, or format in your pesticide petition. Simply replace the instructions that appear in green, i.e., "[insert company name]," with the information specific to your action.

TEMPLATE:

[Monsanto Company]

[Insert petition number]

	EPA has received a pesticide petition ([insert petition number]) from [Monsanto Company, EPA Company Number 524], [1300 I St., NW., Suite 450 East, Washington DC 20052] proposing, pursuant to section 408(d) of the Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a(d), to amend 40 CFR part 180 by establishing a tolerance for residues of [dicamba (3,6-dichloro-o-anisic and its metabolites 3,6-dichloro-5-hydroxy-o-anisic acid (5-OH dicamba) and 3,6-dichloro-2-hydroxybenzoic acid (DCSA)] in or on the raw agricultural commodity [Cotton, undelinted seed] at [3] parts per million (ppm) and [Cotton, gin by products] at [70] parts per million (ppm).  EPA has determined that the petition contains data or information regarding the elements set forth in section 408 (d)(2) of FDDCA; however, EPA has not fully evaluated the sufficiency of the submitted data at this time or whether the data supports granting of the petition. Additional data may be needed before EPA rules on the petition.

A. Residue Chemistry

	1. Plant metabolism. [The nature of dicamba residues in MON 88701 cotton is adequately understood.  The primary route of metabolism of dicamba in MON 88701 cotton is by demethylation to form (3,6-dichloro-salicylic acid (DCSA) and subsequent glycosidation to form conjugates.  DCSA and its conjugates are major metabolites from both pre and postemergence applications of dicamba to MON 88701 cotton, in addition to dicamba.  The current dicamba residue definition as listed in 40 CFR part 180.227(a)(1) for undelinted cottonseed includes dicamba and 5-hydroxydicamba, expressed as dicamba equivalents.  Based on residue and metabolism data,  the proposed residue definition for dicamba in cotton commodities, including dicamba-tolerant cotton,  is: dicamba, DCSA and 5-hydroxydicamba, expressed as dicamba equivalents.

	2. Analytical method. [Adequate enforcement methods are available for the analysis of residues of dicamba and its relevant metabolites in or on plant and livestock commodities. Pesticide Analytical Manual (PAM) Vol. II lists appropriate analytical methods, based on gas chromatography (GC) with electron capture detection (GC/ECD), that are sufficient to provide for the enforcement of proposed dicamba tolerances in cottonseed and cotton gin by-products.]

	3. Magnitude of residues. [Residue data are available for residues of dicamba in MON 88701 cotton.  The magnitude of dicamba, 5-hydroxydicamba, and DCSA, combined in undelinted cottonseed in dicamba acid equivalents ranged from 0.17 to 1.72 ppm, with a median of 0.54 ppm.  Cotton gin by-products samples had residues of dicamba ranging from 5.06 to 29.6 ppm, with a median of 19.7 ppm.

B. Toxicological Profile [EPA has previously evaluated available toxicology data on dicamba and concluded the data are sufficient to merit reregistration.  EPA also found the available data to be adequate to characterize the toxicity of dicamba as it relates to human health including variability and sensitivity of major subgroups of consumers including infants and children.  The nature of dicamba toxicity is discussed in the 2006 Registration Eligibility Decision (RED) and as part of a recent action to establish tolerances 76 FR 55804.

	1. Acute toxicity.  [NA-remove]

	2. Genotoxicity. [NA-remove]

	3. Reproductive and developmental toxicity. [NA-remove]

	4. Subchronic toxicity. [NA-remove]

	5. Chronic toxicity. [NA-remove]

	6. Animal metabolism. [NA-remove]

	7. Metabolite toxicology. [Toxicity studies on DCSA have been conducted to further characterize its toxicity. These data demonstrate that the overall toxicity profiles of dicamba and its DCSA metabolite are substantially similar and that DCSA does not present any new or unusual toxicity concerns beyond what has already been considered for parent dicamba.  Therefore, the established dicamba toxicity endpoints are sufficient to assess potential health risks from dietary exposure to DCSA metabolite.}

	8. Endocrine disruption. [Dicamba does not belong to a class of chemicals known for having adverse effects on the endocrine system. No effects indicative of endocrine disruption have been observed in the various short- and long-term studies conducted with various mammalian species.]

C. Aggregate Exposure

	1. Dietary exposure. [Existing tolerances for dicamba residues in meat and milk are adequate to support the proposed tolerance increases for dicamba in cottonseed and gin by-products. In addition, the proposed new use on MON 88701 cotton does not result in an increase in estimated drinking water exposure beyond that already evaluated by EPA. Consequently, no significant incremental dietary (food plus water) exposure to dicamba residue is anticipated from the proposed tolerances.]

	i. Food. [In support of the proposed tolerances for sweet corn commodities (73 FR 17914), a highly conservative acute dietary assessment was conducted for all dicamba food exposures assuming 100% of crop and livestock food commodities contain tolerance level residues.  Drinking water values were incorporated directly into the assessment. Acute dietary (food plus water) exposure (95[th] percentile) was conservatively estimated to be 0.044 mg/kg bw/day for the general population and 0.109 mg/kg bw/day for the most highly exposed subpopulation of infants < 1year old.  A Tier I chronic dietary assessment was also conducted, using 100% crop treated and tolerance level residue assumptions, and chronic dietary exposure was conservatively estimated to be 0.012 mg/kg bw/day for the general population and 0.030 mg/kg bw/day for the most highly exposed subpopulation of children aged 1-2 years old. The proposed changes in cotton commodity tolerances are not expected to measurably increase these exposure levels.]

	ii. Drinking water. [In support of the proposed tolerances for sweet corn commodities (73 FR 17914), EPA estimated concentrations of dicamba and DCSA in groundwater and surface water using the Pesticide Root Zone Model/Exposure Analysis Modeling System (PRZM/EXAMS) and Screening Concentration in Ground Water (SCI-GROW) models. Combined estimated environmental concentrations (EECs) of dicamba and DCSA for acute exposures are estimated to be 367 parts per billion (ppb) for surface water and 0.016 ppb for ground water.  The combined EECs for chronic exposures are estimated to be 13.8 ppb for surface water and 0.016 ppb for ground water.  Estimates of dietary exposure from drinking water were included in the food exposures reported above. ]

	2. Non-dietary exposure. [Dicamba is currently registered for use on residential sites, including home lawns and golf courses. Residential handlers are likely to be exposed to dicamba residues via dermal and inhalation routes during handling, mixing, loading and applying activities.  Post application exposure to dicamba also exists for adults and children who reenter a treated area.  EPA assessed non-dietary exposure (residential handler and residential post application)  to dicamba in support of the proposed tolerances for sweet corn commodities (73 FR 17914).  Non-dietary exposure to dicamba did not exceed the Agency's level of concern. The proposed tolerances for cotton will not change the magnitude of non-dietary residential exposures.]

D. Cumulative Effects

	[EPA has not made a common mechanism of toxicity finding for dicamba.]

E. Safety Determination

	1. U.S. population. [The proposed dicamba tolerances for cotton undelinted seed and gin by-products do not contribute a significant incremental dietary exposure to the general US population beyond that which has been previously considered by EPA as part of previous regulatory actions.  A conservative dietary exposure analysis (food plus water) was conducted for dicamba in support of the proposed tolerances for sweet corn commodities (73 FR 17914).  In that assessment, dietary exposure as detailed above from all registered uses of dicamba combined utilized only 4.4% aPAD and 2.6% cPAD for the general US population. Considering the completeness of the overall toxicity database supporting this petition, there is reasonable certainty that no harm will result from aggregate exposure arising from current and proposed dicamba uses including all anticipated dietary and non-occupational exposures.]

	2. Infants and children. [The proposed dicamba tolerances for cotton undelinted seed and gin by-products do not contribute a significant incremental dietary exposure to infants and children beyond that which has been previously considered by EPA.  A conservative dietary exposure analysis (food plus water) showed that exposure from all registered dicamba uses contributes only 11% aPAD for the most highly exposed population subgroup of infants less than one year old for acute exposure, and 6.7% cPAD for the most highly exposed population subgroup of children 1-2 years old for chronic exposure (73FR 17914). Considering the completeness of the overall toxicity database supporting this petition, there is reasonable certainty that no harm will result from aggregate exposure arising from current and proposed dicamba uses including all anticipated dietary and non-occupational exposures.]

F. International Tolerances

	[The current maximum residue limit (MRL) for cottonseed in Mexico is 0.2 ppm and 0.04 ppm at CODEX.  There is no MRL for cottonseed in Canada.  There currently are no CODEX, Canadian, or Mexican MRLs for cotton gin by-products.]