more than 21 days. Do not
                                                                    feed to ducks producing eggs
                                                                    for human consumption.
(iii) 10 mg/g of finished feed      Psittacine birds (cockatoos,   Feed continuously for 45               054771
 daily.                              macaws, and parrots)           days. Each bird should
                                     suspected or known to be       consume daily an amount of
                                     infected with psittacosis      medicated feed equal to one
                                     caused by Chlamydia psittaci   fifth of its body weight.
                                     sensitive to                   See paragraph (d)(5) of this
                                     chlortetracycline.             section.
----------------------------------------------------------------------------------------------------------------

    (6) It is used as a free-choice, loose mineral Type C feed as
follows:
    (i) Specifications.

------------------------------------------------------------------------
                                                         International
            Ingredient                   Percent            feed No.
------------------------------------------------------------------------
Dicalcium Phosphate...............              46.20           6-26-335
Sodium Chloride (Salt)............              15.00           6-04-152
Magnesium Oxide...................              10.67           6-02-756
Cottonseed Meal...................              10.00           5-01-625
Trace Mineral/Vitamin Premix \1\..               3.80  .................
Calcium Carbonate.................               3.50           6-01-069
Dried Cane Molasses...............               3.00           4-04-695
Potassium Chloride................               2.00           6-03-755
Mineral Oil.......................               2.00           8-03-123
Iron Oxide........................               0.50           6-02-431
Chlortetracycline Type A medicated               3.33  .................
 article (90 gram/lb).............
------------------------------------------------------------------------
\1\ Content of vitamin and trace mineral premixes may be varied.
  However, they should be comparable to those used for other free-choice
  feeds. Formulation modifications require FDA approval prior to
  marketing. Selenium must comply with 21 CFR 573.920. Ethylenediamine
  dihydroiodide (EDDI) should comply with FDA Compliance Policy Guides
  Sec. 651.100 (CPG 7125.18).

    (ii) Amount. 6,000 grams per ton.
    (iii) Indications for use. Beef and nonlactating dairy cattle: As
an aid in the control of active infection of anaplasmosis caused by
Anaplasma marginale susceptible to chlortetracycline.
    (iv) Limitations. Feed continuously on a free-choice basis at a
rate of 0.5 to 2.0 mg chlortetracycline per pound of body weight per
day.
    (v) Sponsor. See No. 054771 in Sec.  510.600(c) of this chapter.

0
9. In Sec.  558.140, redesignate paragraph (d) as paragraph (e) and add
new paragraph (d) to read as follows:

Sec.  558.140  Chlortetracycline and sulfamethazine.

* * * * *
    (d) Special considerations--(1) Federal law restricts medicated
feed containing this veterinary feed directive (VFD) drug to use by or
on the order of a licensed veterinarian. See Sec.  558.6 for additional
requirements.
    (2) The expiration date of VFDs for chlortetracycline and
sulfamethazine medicated feeds must not exceed 6 months from the date
of issuance. VFDs for chlortetracycline and sulfamethazine shall not be
refilled.
* * * * *

Sec.  558.145  [Removed]

0
10. Remove Sec.  558.145.

0
11. In Sec.  558.175, in paragraph (b), remove ``Approvals'' and in its
place add ``Sponsor''; add paragraph (c); remove and reserve paragraphs
(d)(5) and (6); and add paragraph (e) to read as follows:

Sec.  558.175  Clopidol.

* * * * *
    (c) Related tolerances. See Sec.  556.160 of this chapter.
* * * * *
    (e) Clopidol may also be used in combination with:
    (1) [Reserved]
    (2) [Reserved]
    (3) Chlortetracycline as in Sec.  558.128.
    (4) Lincomycin as in Sec.  558.325.

0
12. In Sec.  558.195, remove and reserve paragraphs (e)(1)(iv) through
(vi), (e)(2)(ii), (e)(2)(iv), and (e)(2)(vii); and add paragraph (e)(4)
to read as follows:

Sec.  558.195  Decoquinate.

* * * * *
    (e) * * *
    (4) Decoquinate may also be used in combination with:
    (i) [Reserved]
    (ii) [Reserved]
    (iii) Chlortetracycline as in Sec.  558.128.
    (iv) Lincomycin as in Sec.  558.325.

0
13. In Sec.  558.198, remove and reserve paragraphs (d)(1)(iv) and (v);
and add paragraph (d)(3) to read as follows:

Sec.  558.198  Diclazuril.

* * * * *
    (d) * * *
    (3) Diclazuril may also be used in combination with virginiamycin
as in Sec.  558.635.

0
14. In Sec.  558.248, revise paragraph (a); redesignate paragraph (d)
as paragraph (e); add new paragraph (d); and revise redesignated
paragraph (e) to read as follows:

Sec.  558.248  Erythromycin.

    (a) Specifications. Type A medicated articles containing 92.5 grams
per pound erythromycin (as the thiocyanate salt).
* * * * *
    (d) Special considerations.--(1) Federal law restricts medicated
feed containing this veterinary feed directive (VFD) drug to use by or
on the order of a licensed veterinarian. See Sec.  558.6 for additional
requirements.
    (2) The expiration date of VFDs for erythromycin medicated feeds
must not exceed 6 months from the date of issuance. VFDs for
erythromycin shall not be refilled.
    (e) Conditions of use--(1) Chickens--

----------------------------------------------------------------------------------------------------------------
                               Combination in
 Erythromycin in grams/ton        grams/ton        Indications for use          Limitations           Sponsor
----------------------------------------------------------------------------------------------------------------
(i) 92.5...................  ..................  Chickens: As an aid in   Feed for 2 days before          061623
                                                  the prevention of        stress and 3 to 6
                                                  chronic respiratory      days after stress.
                                                  disease during periods   Withdraw 24 hours
                                                  of stress.               before slaughter.
(ii) 92.5..................  ..................  Chickens: As an aid in   Feed for 7 to 14 days.          061623
                                                  the prevention of        Withdraw 24 hours
                                                  infectious coryza.       before slaughter.
(iii) 185..................  ..................  Chickens: As an aid in   Feed for 5 to 8 days.           061623
                                                  the prevention and       Withdraw 48 hours
                                                  reduction of lesions     before slaughter. Do
                                                  and in lowering          not use in birds
                                                  severity of chronic      producing eggs for
                                                  respiratory disease      food.
                                                  (CRD).
----------------------------------------------------------------------------------------------------------------

    (2) Turkeys--

----------------------------------------------------------------------------------------------------------------
Erythromycin thiocyanate in    Combination in
         grams/ton                grams/ton        Indications for use          Limitations           Sponsor
----------------------------------------------------------------------------------------------------------------
(i) 92.5...................  ..................  Turkeys: As an aid in    Feed for 2 days before          061623
                                                  the prevention of        stress and 3 to 6
                                                  chronic respiratory      days after stress.
                                                  disease during periods
                                                  of stress.
(ii) 185...................  ..................  Turkeys: As an aid in    Feed for 5 to 8 days.           061623
                                                  the prevention and       Do not use in birds
                                                  reduction of lesions     producing eggs for
                                                  and in lowering          food.
                                                  severity of chronic
                                                  respiratory disease
                                                  (CRD).
----------------------------------------------------------------------------------------------------------------

0
15. In Sec.  558.258, remove and reserve paragraphs (e)(2)(ii) through
(v); and add paragraph (e)(6) to read as follows:

Sec.  558.258  Fenbendazole.

* * * * *
    (e) * * *
    (6) Fenbendazole may also be used in combination with:
    (i) [Reserved]
    (ii) Lincomycin as in Sec.  558.325.

0
16. In Sec.  558.265, remove and reserve paragraphs (d)(1)(iii),
(d)(1)(iv), and (d)(1)(vii); and add paragraph (d)(4) to read as
follows:

Sec.  558.265  Halofuginone.

* * * * *
    (d) * * *
    (4) Halofuginone may also be used in combination with:
    (i) [Reserved]
    (ii) Lincomycin as in Sec.  558.325.
    (iii) Virginiamycin as in Sec.  558.635.

0
17. Revise Sec.  558.274 to read as follows:

Sec.  558.274  Hygromycin B.

    (a) Specifications. Type A medicated articles containing 2.4 or 8
grams hygromycin B per pound (g/lb).
    (b) Sponsor. See No. 058198 in Sec.  510.600(c) of this chapter for
as follows:
    (c) Related tolerances. See Sec.  556.330 of this chapter.
    (d) Special considerations--(1) Federal law restricts medicated
feed containing this veterinary feed directive (VFD) drug to use by or
on the order of a licensed veterinarian. See Sec.  558.6 for additional
requirements.
    (2) The expiration date of VFDs for hygromycin B medicated feeds
must not exceed 6 months from the date of issuance. VFDs for hygromycin
B shall not be refilled.
    (e) Conditions of use. It is used in feed as follows:
    (1) Chickens--

----------------------------------------------------------------------------------------------------------------
                               Combination in
   Hygromycin B grams/ton         grams/ton        Indications for use          Limitations           Sponsor
----------------------------------------------------------------------------------------------------------------
(i) 8 to 12................  ..................  Chickens: For control    Use in complete feed.           058198
                                                  of infections of large   Withdraw 3 days
                                                  roundworms (Ascaris      before slaughter.
                                                  galli), cecal worms
                                                  (Heterakis gallinae),
                                                  and capillary worms
                                                  (Capillaria obsignata).
(ii) [Reserved]
----------------------------------------------------------------------------------------------------------------

    (2) Swine--

----------------------------------------------------------------------------------------------------------------
                               Combination in
   Hygromycin B grams/ton         grams/ton        Indications for use          Limitations           Sponsor
----------------------------------------------------------------------------------------------------------------
(i) 12.....................  ..................  Swine: For control of    In market hogs, use in          058198
                                                  infections of large      complete feed for 8
                                                  roundworms (A. suis),    weeks during the
                                                  nodular worms (O.        growing period.
                                                  dentatum), and           Withdraw 15 days
                                                  whipworms (Trichuris     before slaughter.
                                                  suis).
(ii) [Reserved]
----------------------------------------------------------------------------------------------------------------

0
18. In Sec.  558.300, remove and reserve paragraphs (e)(4) through (7);
and add paragraph (f) to read as follows:

Sec.  558.300  Ivermectin.

* * * * *
    (f) Ivermectin may also be used in combination with:
    (1) [Reserved]
    (2) Lincomycin as in Sec.  558.325.

0
19. In Sec.  558.305, remove paragraphs (e)(2), (e)(3), (e)(5), and
(e)(6); redesignate paragraph (e)(4) as new paragraph (e)(2); and add
paragraph (f) to read as follows:

Sec.  558.305  Laidlomycin.

* * * * *
    (f) Laidlomycin may also be used in combination with
chlortetracycline as in Sec.  558.128.

0
20. In Sec.  558.311, in paragraph (e)(1)(i), in the row entry for
``Bambermycins 1 to 2'', in the ``Lasalocid sodium in grams per ton''
column, add ``(ii) 68 (0.0075 pct) to 113 (0.0125 pct).''; in
paragraphs (e)(1)(vi) and (vii), remove the row entries for
``Oxytetracycline 7.5''; in paragraph (e)(1)(xv), remove the row entry
for ``Virginiamycin 10 to 20''; remove and reserve paragraphs
(e)(1)(iii), (e)(1)(v), and (e)(1)(xx) through (e)(1)(xxviii);
redesignate paragraph (e)(5)(i) as paragraph (e)(5)(ii); and add new
paragraphs (e)(5)(i) and (e)(5)(iii) to read as follows:

Sec.  558.311  Lasalocid.

* * * * *
    (e) * * *
    (5) * * *
    (i) Chlortetracycline as in Sec.  558.128.
* * * * *
    (iii) Virginiamycin as in Sec.  558.635.

0
21. Revise Sec.  558.325 to read as follows:

Sec.  558.325  Lincomycin.

    (a) Specifications. Type A medicated articles containing 20 or 50
grams of lincomycin (as lincomycin hydrochloride) per pound.
    (b) Sponsors. See No. 054771 in Sec.  510.600(c) of this chapter.
    (c) Related tolerances. See Sec.  556.360 of this chapter.
    (d) Special considerations--(1) Federal law restricts medicated
feed containing this veterinary feed directive (VFD) drug to use by or
on the order of a licensed veterinarian. See Sec.  558.6 for additional
requirements.
    (2) The expiration date of VFDs for chlortetracycline and
sulfamethazine medicated feeds must not exceed 6 months from the date
of issuance. VFDs for chlortetracycline and sulfamethazine shall not be
refilled.
    (3) Labeling of Type A medicated articles and Type B and Type C
medicated feeds containing lincomycin shall bear the following:
    (i) ``CAUTION: Do not allow rabbits, hamsters, guinea pigs, horses,
or ruminants access to feeds containing lincomycin. Ingestion by these
species may result in severe gastrointestinal effects.''
    (4) Labeling of medicated feeds containing lincomycin intended for
use in swine shall bear the following:
    (i) ``CAUTION: Occasionally, swine fed lincomycin may within the
first 2 days after the onset of treatment develop diarrhea and/or
swelling of the anus. On rare occasions, some pigs may show reddening
of the skin and irritable behavior. These conditions have been self-
correcting within 5 to 8 days without discontinuing the lincomycin
treatment.''
    (ii) ``CAUTION: The effects of lincomycin on swine reproductive
performance, pregnancy, and lactation have not been determined.''
    (e) Conditions of use--(1) Chickens--

----------------------------------------------------------------------------------------------------------------
                               Combination in
   Lincomycin  grams/ton          grams/ton        Indications for use          Limitations          Sponsors
----------------------------------------------------------------------------------------------------------------
(i) 2......................  ..................  Broilers: For the        Feed as the sole                054771
                                                  control of necrotic      ration. Not for use
                                                  enteritis caused or      in layers, breeders,
                                                  complicated by           or turkeys.
                                                  Clostridium spp. or
                                                  other organisms
                                                  susceptible to
                                                  lincomycin.
(ii) [Reserved]
----------------------------------------------------------------------------------------------------------------

    (2) Swine--

----------------------------------------------------------------------------------------------------------------
                               Combination in
   Lincomycin  grams/ton          grams/ton        Indications for use          Limitations          Sponsors
----------------------------------------------------------------------------------------------------------------
(i) 40.....................  ..................  For control of swine     Feed as sole ration.            054771
                                                  dysentery and the        For use in swine on
                                                  control of porcine       premises with a
                                                  proliferative            history of swine
                                                  enteropathies            dysentery but where
                                                  (ileitis) caused by      symptoms have not yet
                                                  Lawsonia                 occurred, or
                                                  intracellularis.         following use of
                                                                           lincomycin at 100
                                                                           grams (g)/ton for the
                                                                           treatment of swine
                                                                           dysentery and the
                                                                           control of porcine
                                                                           proliferative
                                                                           enteropathies
                                                                           (ileitis).
(ii) 40....................  Fenbendazole, 10    For control of swine     Feed as sole ration to          000061
                              to 80.              dysentery in animals     provide a total dose
                                                  on premises with a       of 9 mg fenbendazole/
                                                  history of swine         kg of body weight
                                                  dysentery, but where     within 3 to 12 days.
                                                  symptoms have not yet    Do not feed to swine
                                                  occurred; and for the    that weigh more than
                                                  removal of: Adult        250 pounds.
                                                  stage lungworms          Lincomycin as
                                                  (Metastrongylus apri     provided by No.
                                                  and M. pudendotectus);   054771; fenbendazole
                                                  adult and larvae (L3,    as provided by No.
                                                  4 stages--liver, lung,   000061 in Sec.
                                                  intestinal forms)        510.600(c) of this
                                                  large roundworms         chapter.
                                                  (Ascaris suum); adult
                                                  stage nodular worms
                                                  (Oesophagostomum
                                                  dentatum, O.
                                                  quadrispinulatum);
                                                  adult stage small
                                                  stomach worms
                                                  (Hyostrongylus
                                                  rubidus); adult and
                                                  larvae (L2, 3, 4
                                                  stages--intestinal
                                                  mucosal forms)
                                                  whipworms (Trichuris
                                                  suis); adult and
                                                  larvae kidney worms
                                                  (Stephanurus dentatus).

(iii) 40...................  Ivermectin, 1.8...  Weaned, growing and      Feed as the only feed           050604
                                                  finishing swine: For     for 7 consecutive
                                                  control of swine         days to provide 0.1
                                                  dysentery on premises    mg ivermectin/kg of
                                                  with a history of        body weight per day.
                                                  swine dysentery, but     A separate feed
                                                  where symptoms have      containing 40 g/ton
                                                  not yet occurred; and    lincomycin may be
                                                  for treatment and        continued to complete
                                                  control of               the lincomycin
                                                  gastrointestinal         treatment. Not to be
                                                  roundworms (Ascaris      fed to swine that
                                                  suum, adults and         weigh more than 250
                                                  fourth-stage larvae;     lbs. Withdraw 5 days
                                                  Ascarops strongylina,    before slaughter.
                                                  adults; Hyostrongylus    Lincomycin as
                                                  rubidus, adults and      provided by No.
                                                  fourth-stage larvae;     054771; ivermectin as
                                                  Oesophagostomum spp.,    provided by No.
                                                  adults and fourth-       050604 in Sec.
                                                  stage larvae); kidney    510.600(c) of this
                                                  worms (Stephanurus       chapter.
                                                  dentatus, adults and
                                                  fourth-stage larvae);
                                                  lungworms
                                                  (Metastrongylus spp.,
                                                  adults); lice
                                                  (Haematopinus suis);
                                                  and mange mites
                                                  (Sarcoptes scabiei
                                                  var. suis).
(iv) 40....................  Pyrantel, 96......  For control of swine     Feed as the sole                066104
                                                  dysentery on premises    ration. Not to be fed
                                                  with a history of        to swine that weigh
                                                  swine dysentery, but     more than 250 pounds.
                                                  where symptoms have      Withdraw 6 days prior
                                                  not yet occurred; as     to slaughter.
                                                  an aid in the            Lincomycin as
                                                  prevention of            provided by No.
                                                  migration and            054771; pyrantel as
                                                  establishment of large   provided by No.
                                                  roundworm (Ascaris       066104 in Sec.
                                                  suum) infections; and    510.600(c) of this
                                                  as an aid in the         chapter.
                                                  prevention of
                                                  establishment of
                                                  nodular worm
                                                  (Oesophagostomum spp.)
                                                  infections.
(v) 40.....................  Pyrantel, 96......  For the treatment and/   Feed for 3 days as the          066104
                                                  or control of swine      sole ration. Not to
                                                  dysentery; for removal   be fed to swine that
                                                  and control of large     weigh more than 250
                                                  roundworm (Ascaris       pounds. Withdraw 24
                                                  suum) infections.        hours prior to
                                                                           slaughter. Lincomycin
                                                                           as provided by No.
                                                                           054771; pyrantel as
                                                                           provided by No.
                                                                           066104 in Sec.
                                                                           510.600(c) of this
                                                                           chapter.
(vi) 40 or 100.............  Pyrantel, 96......  For the treatment and/   For treatment of swine          066104
                                                  or control of swine      dysentery, feed 100
                                                  dysentery; as an aid     grams of lincomycin
                                                  in the prevention of     and 96 grams of
                                                  migration and            pyrantel tartrate per
                                                  establishment of large   ton of complete feed
                                                  roundworm (Ascaris       for 3 weeks or until
                                                  suum) infections; and    clinical signs of the
                                                  as an aid in the         disease disappear,
                                                  prevention of            following with 40
                                                  establishment of         grams of lincomycin
                                                  nodular worm             and 96 grams of
                                                  (Oesophagostomum spp.)   pyrantel tartrate per
                                                  infections.              ton of complete feed
                                                                           as the sole ration.
                                                                           Not to be fed to
                                                                           swine that weigh more
                                                                           than 250 pounds.
                                                                           Withdraw 6 days prior
                                                                           to slaughter.
                                                                           Lincomycin as
                                                                           provided by No.
                                                                           054771; pyrantel as
                                                                           provided by No.
                                                                           066104 in Sec.
                                                                           510.600(c) of this
                                                                           chapter.
(vii) 100..................  ..................  For treatment of swine   Feed as the sole                054771
                                                  dysentery and the        ration for 3 weeks or
                                                  control of porcine       until clinical signs
                                                  proliferative            of the disease
                                                  enteropathies            disappear.
                                                  (ileitis) caused by
                                                  Lawsonia
                                                  intracellularis.
(viii) 100.................  Fenbendazole, 10    For the treatment of     Feed as sole ration to          000061
                              to 80.              swine dysentery; and     provide a total dose
                                                  for the removal of:      of 9 mg fenbendazole/
                                                  Adult stage lungworms    kg of body weight
                                                  (Metastrongylus apri     within 3 to 12 days.
                                                  and M. pudendotectus);   Do not feed to swine
                                                  adult and larvae (L3,    that weigh more than
                                                  4 stages--liver, lung,   250 pounds. Do not
                                                  intestinal forms)        use within 6 days of
                                                  large roundworms         slaughter. Lincomycin
                                                  (Ascaris suum); adult    as provided by No.
                                                  stage nodular worms      054771; fenbendazole
                                                  (Oesophagostomum         as provided by No.
                                                  dentatum, O.             000061 in Sec.
                                                  quadrispinulatum);       510.600(c) of this
                                                  adult stage small        chapter.
                                                  stomach worms
                                                  (Hyostrongylus
                                                  rubidus); adult and
                                                  larvae (L2, 3, 4
                                                  stages--intestinal
                                                  mucosal forms)
                                                  whipworms (Trichuris
                                                  suis); adult and
                                                  larvae kidney worms
                                                  (Stephanurus dentatus).

(ix) 100...................  Ivermectin, 1.8...  Weaned, growing and      Feed as the only feed           050604
                                                  finishing swine: For     for 7 consecutive
                                                  the treatment of swine   days to provide 0.1
                                                  dysentery; and for       mg ivermectin/kg of
                                                  treatment and control    body weight per day.
                                                  of gastrointestinal      A separate feed
                                                  roundworms (Ascaris      containing 100 g/ton
                                                  suum, adults and         lincomycin may be
                                                  fourth-stage larvae;     continued to complete
                                                  Ascarops strongylina,    the lincomycin
                                                  adults; Hyostrongylus    treatment. Not to be
                                                  rubidus, adults and      fed to swine that
                                                  fourth-stage larvae;     weigh more than 250
                                                  Oesophagostomum spp.,    lbs. Withdraw 6 days
                                                  adults and fourth-       before slaughter.
                                                  stage larvae);           Lincomycin as
                                                  kidneyworms              provided by No.
                                                  (Stephanurus dentatus,   054771; ivermectin as
                                                  adults and fourth-       provided by No.
                                                  stage larvae);           050604 in Sec.
                                                  lungworms                510.600(c) of this
                                                  (Metastrongylus spp.,    chapter.
                                                  adults); lice
                                                  (Haematopinus suis);
                                                  and mange mites
                                                  (Sarcoptes scabiei
                                                  var. suis).
(x) 100....................  Pyrantel, 96......  For the treatment of     Feed as the sole                066104
                                                  swine dysentery; as an   ration for 3 weeks or
                                                  aid in the prevention    until clinical signs
                                                  of migration and         of the disease
                                                  establishment of large   disappear. Not to be
                                                  roundworm (Ascaris       fed to swine that
                                                  suum) infections; and    weigh more than 250
                                                  as an aid in the         pounds. Withdraw 6
                                                  prevention of            days prior to
                                                  establishment of         slaughter. Lincomycin
                                                  nodular worm             as provided by No.
                                                  (Oesophagostomum spp.)   054771; pyrantel as
                                                  infections.              provided by No.
                                                                           066104 in Sec.
                                                                           510.600(c) of this
                                                                           chapter.
(xi) 100...................  Pyrantel, 96......  For the treatment and/   Feed for 3 days as the          066104
                                                  or control of swine      sole ration. Not to
                                                  dysentery; for removal   be fed to swine that
                                                  and control of large     weigh more than 250
                                                  roundworm (Ascaris       pounds. Withdraw 24
                                                  suum) infections.        hours prior to
                                                                           slaughter. Lincomycin
                                                                           as provided by No.
                                                                           054771; pyrantel as
                                                                           provided by No.
                                                                           066104 in Sec.
                                                                           510.600(c) of this
                                                                           chapter.
(xii) 100..................  Pyrantel, 800.....  For the treatment and/   Feed as a single                066104
                                                  or control of swine      therapeutic
                                                  dysentery; for removal   treatment. Not to be
                                                  and control of large     fed to swine that
                                                  roundworm (Ascaris       weigh more than 250
                                                  suum) and nodular worm   pounds. Withdraw 24
                                                  (Oesophagostomum spp.)   hours prior to
                                                  infections.              slaughter. Lincomycin
                                                                           as provided by No.
                                                                           054771; pyrantel as
                                                                           provided by No.
                                                                           066104 in Sec.
                                                                           510.600(c) of this
                                                                           chapter.
(xiii) 200.................  ..................  For reduction in the     Feed as sole ration             054771
                                                  severity of swine        for 21 days.
                                                  mycoplasmal pneumonia
                                                  caused by Mycoplasma
                                                  hyopneumoniae.
(xiv) 200..................  Fenbendazole, 10    For reduction in the     Feed as sole ration to          000061
                              to 80.              severity of swine        provide a total dose
                                                  mycoplasmal pneumonia    of 9 mg fenbendazole/
                                                  caused by Mycoplasma     kg of body weight
                                                  hyopneumoniae; and for   within 3 to 12 days.
                                                  the removal of: Adult    Do not feed to swine
                                                  stage lungworms          that weigh more than
                                                  (Metastrongylus apri     250 pounds. Do not
                                                  and M. pudendotectus);   use within 6 days of
                                                  adult and larvae (L3,    slaughter. Lincomycin
                                                  4 stages--liver, lung,   as provided by No.
                                                  intestinal forms)        054771; fenbendazole
                                                  large roundworms         as provided by No.
                                                  (Ascaris suum); adult    000061 in Sec.
                                                  stage nodular worms      510.600(c) of this
                                                  (Oesophagostomum         chapter.
                                                  dentatum, O.
                                                  quadrispinulatum);
                                                  adult stage small
                                                  stomach worms
                                                  (Hyostrongylus
                                                  rubidus); adult and
                                                  larvae (L2, 3, 4
                                                  stages--intestinal
                                                  mucosal forms)
                                                  whipworms (Trichuris
                                                  suis); adult and
                                                  larvae kidney worms
                                                  (Stephanurus dentatus).

(xv) 200...................  Ivermectin, 1.8...  For reduction in the     Feed as the only feed           050604
                                                  severity of swine        for 7 consecutive
                                                  mycoplasmal pneumonia    days to provide 0.1
                                                  caused by Mycoplasma     mg ivermectin/kg of
                                                  hyopneumoniae; and for   body weight per day.
                                                  treatment and control    A separate feed
                                                  of gastrointestinal      containing 200 g/ton
                                                  roundworms (Ascaris      lincomycin may be
                                                  suum, adults and         continued for an
                                                  fourth-stage larvae;     additional 14 days to
                                                  Ascarops strongylina,    complete the
                                                  adults; Hyostrongylus    lincomycin treatment.
                                                  rubidus, adults and      Not to be fed to
                                                  fourth-stage larvae;     swine that weigh more
                                                  Oesophagostomum spp.,    than 250 lbs.
                                                  adults and fourth-       Withdraw 6 days
                                                  stage larvae);           before slaughter.
                                                  kidneyworms              Lincomycin as
                                                  (Stephanurus dentatus,   provided by No.
                                                  adults and fourth-       054771; ivermectin as
                                                  stage larvae);           provided by No.
                                                  lungworms                050604 in Sec.
                                                  (Metastrongylus spp.,    510.600(c) of this
                                                  adults); lice            chapter.
                                                  (Haematopinus suis);
                                                  and mange mites
                                                  (Sarcoptes scabiei
                                                  var. suis).
(xvi) 200..................  Pyrantel, 96......  For reduction in the     Feed as the sole                054771
                                                  severity of swine        ration for 21 days.
                                                  mycoplasmal pneumonia    Not for use in swine
                                                  caused by Mycoplasma     that weigh more than
                                                  hyopneumoniae; and as    250 pounds. Withdraw
                                                  an aid in the            6 days before
                                                  prevention of            slaughter. Lincomycin
                                                  migration and            as provided by No.
                                                  establishment of large   054771; pyrantel as
                                                  roundworm (Ascaris       provided by No.
                                                  suum) infections; aid    066104 in Sec.
                                                  in the prevention of     510.600(c) of this
                                                  establishment of         chapter.
                                                  nodular worm
                                                  (Oesophagostomum spp.)
                                                  infections.
----------------------------------------------------------------------------------------------------------------

0
22. In Sec.  558.342, remove and reserve paragraphs (e)(1)(iii),
(e)(1)(iv), (e)(1)(viii), (e)(1)(ix), and (e)(1)(xi); and revise
paragraph (e)(2) to read as follows:

Sec.  558.342  Melengestrol.

* * * * *
    (e) * * *
    (2) Melengestrol may also be used in combination with:
    (i) Ractopamine as in Sec.  558.500.
    (ii) Tylosin as in Sec.  558.625.
    (iii) Zilpaterol as in Sec.  558.665.

0
23. In Sec.  558.355, revise paragraphs (a) and (b); remove and reserve
paragraphs (f)(1)(viii), (f)(1)(ix), (f)(1)(xiii), (f)(1)(xiv),
(f)(1)(xxi), (f)(1)(xxii), (f)(1)(xxxi), (f)(2)(iv), (f)(3)(ii), and
(f)(3)(xii); and revise paragraph (f)(8) to read as follows:

Sec.  558.355  Monensin.

    (a) Specifications. Type A medicated articles containing 45, 60,
90.7, or 110 grams monensin, USP, per pound.
    (b) Approvals. See sponsor numbers in Sec.  510.600(c) of this
chapter for conditions of use as in paragraph (f) of this section:
    (1) No. 058198 for use as in paragraph (f) of this section.
    (2) No. 054771 for use as in paragraphs (f)(1)(xxiv) and (xxv) of
this section.
    (3) No. 058198 for use as in paragraphs (f)(1)(i), (iii), (iv), and
(v) of this section.
* * * * *
    (f) * * *
    (8) Monensin may also be used in combination with:
    (i) Chlortetracycline as in Sec.  558.128.
    (ii) Decoquinate as in Sec.  558.195.
    (iii) Lincomycin as in Sec.  558.325.
    (iv) Melengestrol acetate as in Sec.  558.342.
    (v) Oxytetracycline as in Sec.  558.128.
    (vi) Ractopamine alone or in combination as in Sec.  558.500.
    (vii) Tilmicosin as in Sec.  558.618.
    (viii) Tylosin as in Sec.  558.625.
    (ix) Virginiamycin as in Sec.  558.635.
    (x) Zilpaterol alone or in combination as in Sec.  558.665.

0
24. In Sec.  558.364, redesignate paragraph (d) as paragraph (e) and
revise paragraphs (a) through (d) to read as follows:

Sec.  558.364  Neomycin sulfate.

    (a) Specifications. Type A medicated article containing 325 grams
neomycin sulfate per pound.
    (b) Sponsor. See No. 054771 in Sec.  510.600(c) of this chapter.
    (c) Related tolerances. See Sec.  556.430 of this chapter.
    (d) Special considerations--(1) Federal law restricts medicated
feed containing this veterinary feed directive (VFD) drug to use by or
on the order of a licensed veterinarian. See Sec.  558.6 for additional
requirements.
    (2) The expiration date of VFDs for neomycin medicated feeds must
not exceed 6 months from the date of issuance. VFDs for neomycin shall
not be refilled.
* * * * *

0
25. In Sec.  558.366, in the table in paragraph (d), remove the row
entries under ``Nicarbazin in grams per ton'' ``27 to 45'' for
``Narasin 27 to 45 and Lincomycin 2 to 4''; and under ``Nicarbazin in
grams per ton'' ``113.5 (0.0125 pct)'' for ``Lincomycin 2 (0.00044
pct)''; and add paragraph (e) to read as follows:

Sec.  558.366  Nicarbazin.

* * * * *
    (e) * * *
    (6) Nicarbazin may also be used in combination with:
    (i) [Reserved]
    (ii) Lincomycin as in Sec.  558.325.

Sec.  558.435  [Removed]

0
26. Remove Sec.  556.435.

0
27. Revise Sec.  558.450 to read as follows:

Sec.  558.450  Oxytetracycline.

    (a) Specifications. Each pound of Type A medicated article
contains:
    (1) Oxytetracycline (from oxytetracycline quaternary salt)
equivalent to 50 or 100 grams oxytetracycline hydrochloride; or
oxytetracycline (from oxytetracycline dihydrate base) equivalent to 10,
30, 50, 100, or 200 grams oxytetracycline hydrochloride.
    (2) Oxytetracycline (from oxytetracycline dihydrate base)
equivalent to 50, 100, or 200 grams oxytetracycline hydrochloride; or
100 grams oxytetracycline hydrochloride.
    (b) Sponsors. See sponsors in Sec.  510.600(c) of this chapter as
follows:

    (1) No. 066104: Type A medicated articles as in paragraph (a)(1) of
this section.
    (2) No. 069254: Type A medicated articles as in paragraph (a)(2) of
this section.
    (c) Related tolerances. See Sec.  556.500 of this chapter.
    (d) Special considerations--(1) Federal law restricts medicated
feed containing this veterinary feed directive (VFD) drug to use by or
on the order of a licensed veterinarian. See Sec.  558.6 for additional
requirements.
    (2) The expiration date of VFDs for oxytetracycline medicated feeds
must not exceed 6 months from the date of issuance. VFDs for
oxytetracycline shall not be refilled.
    (3) In accordance with Sec.  558.5, labeling shall bear the
statement: ``For use in dry animal feed only. Not for use in liquid
feed supplements.''
    (e) Conditions of use--(1) Chickens--

----------------------------------------------------------------------------------------------------------------
                               Combination in
   Oxytetracycline amount         grams/ton        Indications for use          Limitations           Sponsor
----------------------------------------------------------------------------------------------------------------
(i) 100 to 200 g/ton.......  ..................  Chickens: For control    Feed continuously for           066104
                                                  of infectious            7 to 14 days. Do not           069254
                                                  synovitis caused by      feed to chickens
                                                  Mycoplasma synoviae      producing eggs for
                                                  and control of fowl      human consumption. Do
                                                  cholera caused by        not use in feed
                                                  Pasteurella multocida    containing less than
                                                  susceptible to           0.55% dietary
                                                  oxytetracycline.         calcium. Use in such
                                                                           low calcium feeds may
                                                                           result in violative
                                                                           residues. Zero-day
                                                                           withdrawal period.
(ii) 200 g/ton.............  Monensin, 90 to     Broiler chickens: As an  Feed continuously as            066104
                              110.                aid in the prevention    the sole ration. Do
                                                  of coccidiosis caused    not feed to laying
                                                  by Eimeria necatrix,     chickens. Do not feed
                                                  E. tenella, E.           to chickens over 16
                                                  acervulina, E.           weeks of age. Do not
                                                  brunetti, E. mivati,     use in feed
                                                  and E. maxima; and for   containing less than
                                                  the control of           0.55% dietary
                                                  complicated chronic      calcium. Use in such
                                                  respiratory disease      low calcium feeds may
                                                  (CRD or air sac          result in violative
                                                  infection) caused by     residues. Withdraw 72
                                                  Mycoplasma               hours before
                                                  gallisepticum and        slaughter. See Sec.
                                                  Escherichia coli.        558.355(d) of this
                                                                           chapter
                                                                           Oxytetracycline as
                                                                           provided by No.
                                                                           066104; monensin as
                                                                           provided by No.
                                                                           058198 in Sec.
                                                                           510.600(c) of this
                                                                           chapter.
(iii) 400 g/ton............  ..................  Chickens: For control    Feed continuously for           066104
                                                  of chronic respiratory   7 to 14 days. Do not           069254
                                                  disease (CRD) and air    feed to chickens
                                                  sac infection caused     producing eggs for
                                                  by Mycoplasma            human consumption. Do
                                                  gallisepticum and        not use in feed
                                                  Escherichia coli         containing less than
                                                  susceptible to           0.55% dietary
                                                  oxytetracycline.         calcium. Use in such
                                                                           low calcium feeds may
                                                                           result in violative
                                                                           residues. Zero-day
                                                                           withdrawal period.
(iv) 400 g/ton.............  Robenidine, 30....  Broiler chickens: As an  Feed continuously for           066104
                                                  aid in the prevention    7 to 14 days. Do not
                                                  of coccidiosis caused    feed to chickens
                                                  by Eimeria necatrix,     producing eggs for
                                                  E. tenella, E.           human consumption. Do
                                                  acervulina, E.           not use in feed
                                                  brunetti, E. mivati,     containing less than
                                                  and E. maxima; and for   0.55% dietary
                                                  the control of chronic   calcium. Use in such
                                                  respiratory disease      low calcium feeds may
                                                  (CRD) and air sac        result in violative
                                                  infection caused by      residues. Withdraw 5
                                                  Mycoplasma               days before
                                                  gallisepticum and        slaughter.
                                                  Escherichia coli         Oxytetracycline as
                                                  susceptible to           provided by No.
                                                  oxytetracycline.         066104; robenidine as
                                                                           provided by No.
                                                                           054771 in Sec.
                                                                           510.600(c) of this
                                                                           chapter.
(v) 500 g/ton..............  ..................  Chickens: For reduction  Feed continuously for           066104
                                                  of mortality due to      5 days. Do not feed            069254
                                                  air sacculitis (air      to chickens producing
                                                  sac infection) caused    eggs for human
                                                  by E. coli susceptible   consumption. Do not
                                                  to oxytetracycline.      use in feed
                                                                           containing less than
                                                                           0.55% dietary
                                                                           calcium. Use in such
                                                                           low calcium feeds may
                                                                           result in violative
                                                                           residues. Withdraw 24
                                                                           hours before
                                                                           slaughter.
(vi) 500 g/ton.............  Monensin, 90 to     Broiler chickens: As an  Feed for 5 days as the          066104
                              100.                aid in the prevention    sole ration. Treat at
                                                  of coccidiosis caused    first clinical signs
                                                  by Eimeria necatrix,     of the disease. Do
                                                  E. tenella, E.           not feed to laying
                                                  acervulina, E.           chickens. Do not feed
                                                  brunetti, E. mivati,     to chickens over 16
                                                  and E. maxima; and as    weeks of age. Do not
                                                  an aid in the            use in feed
                                                  reduction of mortality   containing less than
                                                  due to air-sacculitis    0.55% dietary
                                                  (air sac infection)      calcium. Use in such
                                                  caused by Escherichia    low calcium feeds may
                                                  coli sensitive to        result in violative
                                                  oxytetracycline.         residues. Withdraw 72
                                                                           hours before
                                                                           slaughter. See Sec.
                                                                           558.355(d) of this
                                                                           chapter.
                                                                           Oxytetracycline as
                                                                           provided by No.
                                                                           066104; monensin as
                                                                           provided by No.
                                                                           058198 in Sec.
                                                                           510.600(c) of this
                                                                           chapter.

(vii) 500 g/ton............  Salinomycin, 40 to  Chickens: For the        Feed for 5 days as the          066104
                              60.                 prevention of            sole ration. Treat at          016592
                                                  coccidiosis caused by    first clinical signs
                                                  Eimeria necatrix, E.     of the disease. Do
                                                  tenella, E.              not feed to laying
                                                  acervulina, E.           chickens. Do not use
                                                  brunetti, E. mivati,     in feed containing
                                                  and E. maxima; and as    less than 0.55%
                                                  an aid in the            dietary calcium. Use
                                                  reduction of mortality   in such low calcium
                                                  due to air-sacculitis    feeds may result in
                                                  (air sac infection)      violative residues.
                                                  caused by E. coli        Withdraw 24 hours
                                                  sensitive to             before slaughter.
                                                  oxytetracycline.         Oxytetracycline as
                                                                           provided by No.
                                                                           066104; salinomycin
                                                                           as provided by No.
                                                                           016592 in Sec.
                                                                           510.600(c) of this
                                                                           chapter.
----------------------------------------------------------------------------------------------------------------

    (2) Turkeys--

----------------------------------------------------------------------------------------------------------------
      Oxytetracycline amount             Indications for use                Limitations               Sponsor
----------------------------------------------------------------------------------------------------------------
(i) 100 g/ton.....................  Turkeys: For control of        Feed continuously for 7 to 14          066104
                                     hexamitiasis caused by         days. Do not feed to turkeys          069254
                                     Hexamita meleagridis           producing eggs for human
                                     susceptible to                 consumption. Zero-day
                                     oxytetracycline.               withdrawal period.
(ii) 200 g/ton....................  Turkeys: For control of        Feed continuously for 7 to 14          066104
                                     infectious synovitis caused    days. Do not feed to turkeys          069254
                                     by M. synoviae susceptible     producing eggs for human
                                     to oxytetracycline.            consumption. For No. 066104,
                                                                    withdraw 5 days before
                                                                    slaughter. For No. 069254,
                                                                    zero-day withdrawal period.
(iii) 25 mg/lb of body weight       Turkeys: For control of        Feed continuously for 7 to 14          066104
 daily.                              complicating bacterial         days. Do not feed to turkeys          069254
                                     organisms associated with      producing eggs for human
                                     bluecomb (transmissible        consumption. For No. 066104,
                                     enteritis; coronaviral         withdraw 5 days before
                                     enteritis) susceptible to      slaughter. For No. 069254,
                                     oxytetracycline.               zero-day withdrawal period.
----------------------------------------------------------------------------------------------------------------

    (3) Swine--

----------------------------------------------------------------------------------------------------------------
                               Combination in
   Oxytetracycline amount         grams/ton        Indications for use          Limitations           Sponsor
----------------------------------------------------------------------------------------------------------------
(i) 10 mg/lb of body weight  ..................  1. Swine: For treatment  Feed continuously for           066104
 daily.                                           of bacterial enteritis   7 to 14 days.                  069254
                                                  caused by Escherichia
                                                  coli and Salmonella
                                                  choleraesuis
                                                  susceptible to
                                                  oxytetracycline and
                                                  treatment of bacterial
                                                  pneumonia caused by
                                                  Pasteurella multocida
                                                  susceptible to
                                                  oxytetracycline.
                                                 2. Breeding swine: For   Feed continuously for           066104
                                                  control and treatment    14 days.                       069254
                                                  of leptospirosis
                                                  (reducing the
                                                  incidence of abortion
                                                  and shedding of
                                                  leptospirae) caused by
                                                  Leptospira pomona
                                                  susceptible to
                                                  oxytetracycline.
(ii) 10 mg/lb of body        Carbadox, 10 to 25  Swine: For treatment of  Feed continuously as            066104
 weight daily.                                    bacterial enteritis      the sole ration for 7
                                                  caused by E. coli and    to 14 days. Not for
                                                  Salmonella               use in pregnant swine
                                                  choleraesuis             or swine intended for
                                                  susceptible to           breeding purposes. Do
                                                  oxytetracycline and      not mix in feeds
                                                  treatment of bacterial   containing bentonite.
                                                  pneumonia caused by      Do not feed to swine
                                                  Pasteurella multocida    within 42 days of
                                                  susceptible to           slaughter.
                                                  oxytetracycline; and     Oxytetracycline and
                                                  for increased rate of    carbadox as provided
                                                  weight gain and          by No. 066104 in Sec.
                                                  improved feed              510.600(c) of this
                                                  efficiency.              chapter.
----------------------------------------------------------------------------------------------------------------

    (4) Cattle--

----------------------------------------------------------------------------------------------------------------
                               Combination in
   Oxytetracycline amount         grams/ton        Indications for use          Limitations           Sponsor
----------------------------------------------------------------------------------------------------------------
(i) 10 mg/lb of body weight  ..................  1. Calves and beef and   Feed continuously for           066104
 daily.                                           nonlactating dairy       7 to 14 days. For No.          069254
                                                  cattle: For treatment    069254, withdraw 5
                                                  of bacterial enteritis   days before
                                                  caused by Escherichia    slaughter. For No.
                                                  coli and bacterial       066104, zero-day
                                                  pneumonia (shipping      withdrawal period.
                                                  fever complex) caused
                                                  by Pasteurella
                                                  multocida susceptible
                                                  to oxytetracycline.
                                                 2. Calves: For           Feed continuously for           066104
                                                  treatment of bacterial   7 to 14 days in milk           069254
                                                  enteritis caused by E.   replacer or starter
                                                  coli susceptible to      feed. This product is
                                                  oxytetracycline.         not approved for use
                                                                           in female dairy
                                                                           cattle 20 months of
                                                                           age or older,
                                                                           including dry dairy
                                                                           cows. Use in these
                                                                           cattle may cause drug
                                                                           residues in milk and/
                                                                           or in calves born to
                                                                           these cows. For No.
                                                                           069254, withdraw 5
                                                                           days before
                                                                           slaughter. For No.
                                                                           066104, zero-day
                                                                           withdrawal period.
(ii) 75 mg/head/day........  ..................  Growing cattle (over     Feed continuously.....          066104
                                                  400 lb): For reduction                                  069254
                                                  of incidence of liver
                                                  abscesses.
(iii) 0.5 to 2.0 g/head/day  ..................  Cattle: For prevention   Feed 3 to 5 days                066104
                                                  and treatment of the     before and after               069254
                                                  early stages of          arrival in feedlots.
                                                  shipping fever complex.
----------------------------------------------------------------------------------------------------------------

    (5) Minor species--

----------------------------------------------------------------------------------------------------------------
       Oxytetracycline amount              Indications for use               Limitations              Sponsor
----------------------------------------------------------------------------------------------------------------
(i) 10 mg/lb of body weight daily...  Sheep: For treatment of       Feed continuously for 7 to            066104
                                       bacterial enteritis caused    14 days; withdraw 5 days             069254
                                       by E. coli and bacterial      before slaughter.
                                       pneumonia caused by P.
                                       multocida susceptible to
                                       oxytetracycline.
(ii) 200 mg/colony..................  Honey bees: For control of    Remove at least 6 weeks               066104
                                       American foulbrood caused     prior to main honey flow.            069254
                                       by Paenibacillus larvae and
                                       European foulbrood caused
                                       by Streptococcus pluton
                                       susceptible to
                                       oxytetracycline.
(iii) 250 mg/kilogram of fish/day     Pacific salmon: For marking   For salmon not over 30 g              066104
 (11.35 g/100 lb of fish/day).         of skeletal tissue.           body weight; administer as
                                                                     sole ration for 4
                                                                     consecutive days; fish not
                                                                     to be liberated for at
                                                                     least 7 days following the
                                                                     last administration of
                                                                     medicated feed.
(iv) 2.5 to 3.75 g/100 lb of fish/    1. Salmonids: For control of  Administer in mixed ration            066104
 day.                                  ulcer disease caused by       for 10 days; do not
                                       Haemophilus piscium,          liberate fish or slaughter
                                       furunculosis caused by        fish for food for 21 days
                                       Aeromonas salmonicida,        following the last
                                       bacterial hemorrhagic         administration of medicated
                                       septicemia caused by A.       feed.
                                       liquefaciens, and
                                       pseudomonas disease.
                                      2. Catfish: For control of    Administer in mixed ration            066104
                                       bacterial hemorrhagic         for 10 days; do not
                                       septicemia caused by A.       liberate fish or slaughter
                                       liquefaciens and              fish for food for 21 days
                                       pseudomonas disease.          following the last
                                                                     administration of medicated
                                                                     feed; do not administer
                                                                     when water temperature is
                                                                     below 16.7 [deg]C (62
                                                                     [deg]F).
(v) 3.75 g/100 lb of fish/day.......  1. Freshwater-reared          Administer in mixed ration            066104
                                       salmonids: For control of     for 10 days; do not
                                       mortality due to coldwater    liberate fish or slaughter
                                       disease associated with       fish for food for 21 days
                                       Flavobacterium                following the last
                                       psychrophilum.                administration of medicated
                                                                     feed.
                                      2. Freshwater-reared          Administer in mixed ration            066104
                                       Oncorhynchus mykiss: For      for 10 days; do not
                                       control of mortality due to   liberate fish or slaughter
                                       columnaris disease            fish for food for 21 days
                                       associated with               following the last
                                       Flavobacterium columnare.     administration of medicated
                                                                     feed.
(vi) 1 g/lb of medicated feed.......  Lobsters: For control of      Administer as sole ration             066104
                                       gaffkemia caused by           for 5 consecutive days;
                                       Aerococcus viridans.          withdraw medicated feed 30
                                                                     days before harvesting
                                                                     lobsters.
----------------------------------------------------------------------------------------------------------------

0
28. In Sec.  558.455, revise paragraph (d); remove and reserve
paragraphs (e)(1)(i), (e)(2)(i), (e)(3)(i), (e)(4)(i), (e)(4)(ii), and
(e)(4)(iv); and in paragraph (e)(4)(v), remove ``increased rate of
weight gain; improved feed efficiency, and'' to read as follows:

Sec.  558.455  Oxytetracycline and neomycin.

* * * * *
    (d) Special considerations--(1) Federal law restricts medicated
feed containing this veterinary feed directive (VFD) drug to use by or
on the order of a licensed veterinarian. See Sec.  558.6 for additional
requirements.
    (2) The expiration date of VFDs for oxytetracycline and neomycin

medicated feeds must not exceed 6 months from the date of issuance.
VFDs for oxytetracycline and neomycin shall not be refilled.
    (3) Cattle feeds shall bear the following warning statement: ``Use
of more than one product containing neomycin or failure to follow
withdrawal times may result in illegal drug residues.''
* * * * *

Sec.  558.460  [Removed]

0
29. Remove Sec.  558.460.

0
30. In Sec.  558.485, remove paragraphs (e)(1)(v) through (xii); and
add paragraph (e)(3) to read as follows:

Sec.  558.485   Pyrantel.

* * * * *
    (e) * * *
    (3) Pyrantel may also be used in combination with:
    (i) Lincomycin as in Sec.  558.325.
    (ii) Tylosin as in Sec.  558.325.

0
31. In Sec.  558.500, remove and reserve paragraphs (e)(1)(ii), (iii),
and (iv), (e)(2)(iv), (e)(2)(ix) and (x); remove paragraph
(e)(2)(xiii); and add paragraph (e)(4) to read as follows:

Sec.  558.500  Ractopamine.

* * * * *
    (e) * * *
    (4) Ractopamine may also be used in combination with tylosin in as
in Sec.  558.625.

0
32. In Sec.  558.515, in the table in paragraph (d), remove the row
entries for ``Chlortetracycline 100 to 200'', ``Chlortetracycline 200
to 400'', ``Chlortetracycline 500'', ``Lincomycin 2'', and
``Oxytetracycline 400'' in the ``Combination in grams/ton'' column; and
add paragraph (e) to read as follows:

Sec.  558.515  Robenidine.

* * * * *
    (e) Robenidine may also be used in combination with:
    (1) Chlortetracycline as in Sec.  558.128.
    (2) Lincomycin as in Sec.  558.325.
    (3) Oxytetracycline as in Sec.  558.450.

0
33. In Sec.  558.550, remove and reserve paragraphs (d)(1)(x),
(d)(1)(xi), (d)(1)(xiii), and (d)(1)(xvi); and revise paragraph (d)(4)
to read as follows:

Sec.  558.550  Salinomycin.

* * * * *
    (d) * * *
    (5) Salinomycin may also be used in combination with:
    (i) [Reserved]
    (ii) [Reserved]
    (iii) Chlortetracycline as in Sec.  558.128.
    (iv) Lincomycin as in Sec.  558.325.
    (v) Oxytetracycline as in Sec.  558.450.
    (vi) Virginiamycin as in Sec.  558.635.

0
34. In Sec.  558.555, remove paragraphs (d)(3) through (5); (e)(3) and
(e)(4); remove and reserve paragraph (e)(2); and add paragraph (f) to
read as follows:

Sec.  558.555  Semduramycin.

* * * * *
    (f) Semduramycin may also be used in combination with virginiamycin
as in Sec.  558.635.

0
35. In Sec.  558.575, revise the section heading; redesignate
paragraphs (b), (c), and (d) as paragraphs (c), (d), and (e); revise
paragraph (a); and add new paragraphs (b) and (d) to read as follows:

Sec.  558.575  Sulfadimethoxine and ormetoprim.

    (a) Specifications. Type A medicated articles containing either:
    (1) 25 percent sulfadimethoxine and 15 percent ormetoprim; or
    (2) 25 percent sulfadimethoxine and 5 percent ormetoprim.
    (b) Sponsors. See sponsors in Sec.  510.600(c) of this chapter for
use as in paragraph (d) of this section:
    (1) No. 054771 for use of the product described in paragraph (a)(1)
as in paragraphs (e)(1), (e)(2), (e)(3), (e)(4), and (e)(7) of this
section.
    (2) No. 015331 for use of the product described in paragraph (a)(2)
as in paragraphs (e)(5) and (e)(6) of this section.
* * * * *
    (d) Special considerations.--(1) Federal law restricts medicated
feed containing this veterinary feed directive (VFD) drug to use by or
on the order of a licensed veterinarian. See Sec.  558.6 for additional
requirements.
    (2) The expiration date of VFDs for sulfadimethoxine and ormetoprim
medicated feeds must not exceed 6 months from the date of issuance.
VFDs for sulfadimethoxine and ormetoprim shall not be refilled.
* * * * *

0
36. Revise Sec.  558.582 to read as follows:

Sec.  558.582  Sulfamerazine.

    (a) Specifications. Type A medicated articles containing 99 percent
sulfamerazine.
    (b) Sponsor. See No. 054771 in Sec.  510.600(c) of this chapter.
    (c) Related tolerances. See Sec.  556.660 of this chapter.
    (d) Special considerations--(1) Federal law restricts medicated
feed containing this veterinary feed directive (VFD) drug to use by or
on the order of a licensed veterinarian. See Sec.  558.6 for additional
requirements.
    (2) The expiration date of VFDs for sulfamerazine medicated feeds
must not exceed 6 months from the date of issuance. VFDs for
sulfamerazine shall not be refilled.
    (e) Conditions of use. It is used in fish feed for as follows:

----------------------------------------------------------------------------------------------------------------
                                Combination in
   Sulfamerazine grams/ton         grams/ton        Indications for use         Limitations           Sponsor
----------------------------------------------------------------------------------------------------------------
(1) To deliver 10 grams of    ..................  Rainbow trout, brook    Formulate to deliver            054771
 sulfamerazine per 100                             trout, and brown        10 grams of
 pounds of fish per day.                           trout: For control of   sulfamerazine per 100
                                                   furunculosis.           pounds of fish per
                                                                           day. Treat for not
                                                                           more than 14 days. Do
                                                                           not treat within 3
                                                                           weeks of marketing or
                                                                           stocking in stream
                                                                           open to fishing.
(2) [Reserved]..............
----------------------------------------------------------------------------------------------------------------

0
37. Revise Sec.  558.586 to read as follows:

Sec.  558.586  Sulfaquinoxaline.

    (a) Specifications. Type A medicated articles containing 40 percent
sulfaquinoxaline.
    (b) Sponsor. See No. 016592 in Sec.  510.600(c) of this chapter.
    (c) Related tolerances. See Sec.  556.685 of this chapter.
    (d) Special considerations--(1) Federal law restricts medicated
feed containing this veterinary feed directive (VFD) drug to use by or
on the order of a licensed veterinarian. See Sec.  558.6 for additional
requirements.
    (2) The expiration date of VFDs for sulfaquinoxaline medicated
feeds must not exceed 6 months from the date of issuance. VFDs for
sulfaquinoxaline shall not be refilled.
    (e) Conditions of use--(1) Chickens--

----------------------------------------------------------------------------------------------------------------
 Sulfaquinoxaline in grams/    Combination in
            ton                   grams/ton        Indications for use          Limitations           Sponsor
----------------------------------------------------------------------------------------------------------------
(i) 0.015 percent..........  ..................  As an aid in preventing  Feed continuously from          016592
                                                  outbreaks of             the time birds are
                                                  coccidiosis caused by    placed on litter and
                                                  Eimeria tenella, E.      continue past the age
                                                  necatrix, E.             when coccidiosis is
                                                  acervulina, E. maxima,   ordinarily a hazard.
                                                  and E. brunetti under    If death losses
                                                  average conditions of    exceed 0.5 percent in
                                                  exposure.                a 2-day period,
                                                                           obtain a laboratory
                                                                           diagnosis. If
                                                                           coccidiosis is the
                                                                           cause, use the
                                                                           sulfaquinoxaline
                                                                           levels recommended
                                                                           for control of
                                                                           outbreaks, returning
                                                                           to the original
                                                                           dosage schedule after
                                                                           the outbreak has
                                                                           subsided. Losses may
                                                                           result from
                                                                           intercurrent disease,
                                                                           other conditions
                                                                           affecting drug
                                                                           intake, or variant
                                                                           strains of coccidia
                                                                           species which can
                                                                           contribute to the
                                                                           virulence of
                                                                           coccidiosis under
                                                                           field conditions. Do
                                                                           not treat chickens
                                                                           within 10 days of
                                                                           slaughter. Do not
                                                                           medicate chickens
                                                                           producing eggs for
                                                                           human consumption.
(ii) 0.0175 percent........  ..................  As an aid in preventing  Feed continuously from          016592
                                                  outbreaks of             the time birds are
                                                  coccidiosis caused by    placed on litter and
                                                  Eimeria tenella, E.      continue past the age
                                                  necatrix, E.             when coccidiosis is
                                                  acervulina, E. maxima,   ordinarily a hazard.
                                                  and E. brunetti where    If death losses
                                                  excessive exposure to    exceed 0.5 percent in
                                                  coccidia is increased    a 2-day period,
                                                  due to overcrowding or   obtain a laboratory
                                                  other management         diagnosis. If
                                                  factors.                 coccidiosis is the
                                                                           cause, use the
                                                                           sulfaquinoxaline
                                                                           levels recommended
                                                                           for control of
                                                                           outbreaks, returning
                                                                           to the original
                                                                           dosage schedule after
                                                                           the outbreak has
                                                                           subsided. Losses may
                                                                           result from
                                                                           intercurrent disease,
                                                                           other conditions
                                                                           affecting drug
                                                                           intake, or variant
                                                                           strains of coccidia
                                                                           species which can
                                                                           contribute to the
                                                                           virulence of
                                                                           coccidiosis under
                                                                           field conditions. Do
                                                                           not treat chickens
                                                                           within 10 days of
                                                                           slaughter. Do not
                                                                           medicate chickens
                                                                           producing eggs for
                                                                           human consumption.
(iii) 0.1 to 0.05 percent..  ..................  As an aid in             Feed at 0.1 percent             016592
                                                  controlling outbreaks    level for first 48 to
                                                  of coccidiosis caused    72 hours. Skip 3
                                                  by Eimeria tenella, E.   days; 0.05 percent
                                                  necatrix, E.             for 2 days, skip 3
                                                  acervulina, E. maxima,   days; 0.05 percent
                                                  and E. brunetti.         for 2 days. If bloody
                                                                           droppings recur, give
                                                                           0.05 percent for
                                                                           another 2 days. Do
                                                                           not treat chickens
                                                                           within 10 days of
                                                                           slaughter. Do not
                                                                           medicate chickens
                                                                           producing eggs for
                                                                           human consumption.
(iv) 0.05 or 0.1 percent...  ..................  As an aid in the         Feed 0.1 percent for            016592
                                                  control of acute fowl    48 to 72 hours.
                                                  cholera caused by        Mortality should be
                                                  Pasteurella multocida    brought under
                                                  susceptible to           control. After
                                                  sulfaquinoxaline and     medication, move
                                                  fowl typhoid caused by   birds to clean ground
                                                  Salmonella gallinarum    or to a clean house.
                                                  susceptible to           If disease recurs,
                                                  sulfaquinoxaline.        use 0.05 percent in
                                                                           feed again for 2
                                                                           days. Do not treat
                                                                           chickens or turkeys
                                                                           within 10 days of
                                                                           slaughter for food.
                                                                           Do not medicate
                                                                           chickens or turkeys
                                                                           producing eggs for
                                                                           human consumption.
----------------------------------------------------------------------------------------------------------------

    (2) Turkeys--

----------------------------------------------------------------------------------------------------------------
 Sulfaquinoxaline in grams/    Combination in
            ton                   grams/ton        Indications for use          Limitations           Sponsor
----------------------------------------------------------------------------------------------------------------
(i) 0.0175 percent.........  ..................  As an aid in preventing  Feed continuously               016592
                                                  outbreaks of             during time birds are
                                                  coccidiosis caused by    closely confined. May
                                                  Eimeria meleagrimitis    be continued for a
                                                  and E. adenoeides.       week to 10 days after
                                                                           flock is transferred
                                                                           to range to reduce
                                                                           danger of an outbreak
                                                                           following moving of
                                                                           the flock. Do not
                                                                           treat turkeys within
                                                                           10 days of slaughter.
                                                                           Do not medicate
                                                                           turkeys producing
                                                                           eggs for human
                                                                           consumption.
(ii) 0.05 percent..........  ..................  As an aid in             Feed for 2 days.                016592
                                                  controlling outbreaks    Follow with 3 days on
                                                  of coccidiosis caused    regular feed and 2
                                                  by Eimeria               more days on 0.05
                                                  meleagrimitis and E.     percent
                                                  adenoeides.              sulfaquinoxaline
                                                                           feed. Again follow
                                                                           with 3 days on
                                                                           regular feed and 2
                                                                           more days on 0.05
                                                                           percent
                                                                           sulfaquinoxaline
                                                                           feed. Continue this
                                                                           schedule if necessary
                                                                           until all signs of
                                                                           the outbreaks have
                                                                           subsided. Do not
                                                                           treat turkeys within
                                                                           10 days of slaughter.
                                                                           Do not medicate
                                                                           turkeys producing
                                                                           eggs for human
                                                                           consumption.
(iii) 0.05 or 0.1 percent..  ..................  As an aid in the         Feed 0.1 percent for            016592
                                                  control of acute fowl    48 to 72 hours.
                                                  cholera caused by        Mortality should be
                                                  Pasteurella multocida    brought under
                                                  susceptible to           control. After
                                                  sulfaquinoxaline and     medication, move
                                                  fowl typhoid caused by   birds to clean ground
                                                  Salmonella gallinarum    or to a clean house.
                                                  susceptible to           If disease recurs,
                                                  sulfaquinoxaline.        use 0.05 percent in
                                                                           feed again for 2
                                                                           days. Do not treat
                                                                           chickens or turkeys
                                                                           within 10 days of
                                                                           slaughter for food.
                                                                           Do not medicate
                                                                           chickens or turkeys
                                                                           producing eggs for
                                                                           human consumption.
----------------------------------------------------------------------------------------------------------------

    (3) Rabbits--

----------------------------------------------------------------------------------------------------------------
 Sulfaquinoxaline in grams/    Combination in
            ton                   grams/ton        Indications for use          Limitations           Sponsor
----------------------------------------------------------------------------------------------------------------
(i) 0.025 percent..........  ..................  As an aid in preventing  Treatment to be                 016592
                                                  coccidiosis caused by    started after
                                                  Eimeria stiedae.         weaning. Feed
                                                                           continuously for 30
                                                                           days or feed
                                                                           medicated feed for 2
                                                                           days out of every
                                                                           week until marketing.
                                                                           Do not treat within
                                                                           10 days of slaughter.
(ii) 0.1 percent...........  ..................  As an aid in             Feed for 2 weeks. Do            016592
                                                  controlling outbreaks    not treat within 10
                                                  of coccidiosis caused    days of slaughter.
                                                  by Eimeria stiedae.
----------------------------------------------------------------------------------------------------------------

0
38. In Sec.  558.612, remove paragraphs (e)(1)(i) and (e)(1)(iii);
redesignate paragraphs (e)(1)(ii) and (e)(1)(iv) as new paragraphs
(e)(1)(i) and (ii); and add paragraph (e)(2) to read as follows:

Sec.  558.612  Tiamulin.

* * * * *
    (e) * * *
    (2) Tiamulin may also be used in combination with chlortetracycline
as in Sec.  558.128.

0
39. Amend Sec.  558.625 as follows:
0
a. Remove paragraph (d);
0
b. Redesignate paragraphs (c), (e), and (f) as paragraphs (d), (c) and
(e); and
0
c. Revise paragraph (b) and redesignated paragraphs (d) and (e).
    The revisions read as follows:

Sec.  558.625   Tylosin.

* * * * *
    (b) Sponsors. See sponsor numbers in Sec.  510.600(c) of this
chapter.
    (1) No. 016592: Type medicated article containing 100 grams per
pound.
    (2) No. 054771: Type medicated article containing 40 grams per
pound.
    (3) No. 058198: Type medicated article containing 10, 40, or 100
grams per pound.
    (4) No. 066104: Type medicated article containing 20 or 40 grams
per pound.
    (c) Related tolerances. See Sec.  556.360 of this chapter.
    (d) Special considerations--(1) Federal law restricts medicated
feed containing this veterinary feed directive (VFD) drug to use by or
on the order of a licensed veterinarian. See Sec.  558.6 for additional
requirements.
    (2) The expiration date of VFDs for oxytetracycline medicated feeds
must not exceed 6 months from the date of issuance. VFDs for
oxytetracycline shall not be refilled.
    (3) Type C medicated feeds for cattle may be manufactured from
tylosin liquid Type B medicated feeds which have a pH between 4.5 and
6.0 and which bear appropriate mixing directions as follows:
    (i) For liquid feeds stored in recirculating tank systems:
Recirculate immediately prior to use for not less than 10 minutes,
moving not less than 1 percent of the tank contents per minute from the
bottom of the tank to the top. Recirculate daily as described even when
not used.
    (ii) For liquid feeds stored in mechanical, air, or other
agitation-type tank systems: Agitate immediately prior to use for not
less than 10 minutes, creating a turbulence at the bottom of

the tank that is visible at the top. Agitate daily as described even
when not used.
    (e) Conditions of use--(1) Swine--

----------------------------------------------------------------------------------------------------------------
                               Combination in
     Tylosin  grams/ton           grams/ton        Indications for use          Limitations          Sponsors
----------------------------------------------------------------------------------------------------------------
(i) 40 or 100..............  ..................  For control of swine     Feed as the sole                016592
                                                  dysentery associated     ration 100 g of                054771
                                                  with Brachyspira         tylosin per ton of             058198
                                                  hyodysenteriae.          complete feed for at           066104
                                                                           least 3 weeks. Follow
                                                                           with 40 grams per ton
                                                                           of complete feed
                                                                           until market weight.
(ii) 40 or 100.............  Pyrantel, 96......  For control of swine     Feed as the sole                066104
                                                  dysentery associated     ration 100 g of
                                                  with Brachyspira         tylosin per ton of
                                                  hyodysenteriae; and as   complete feed for at
                                                  an aid in the            least 3 weeks. Follow
                                                  prevention of            with 40 grams per ton
                                                  migration and            of complete feed
                                                  establishment of large   until market weight.
                                                  roundworm (Ascaris       Tylosin phosphate and
                                                  suum) infections; aid    pyrantel as provided
                                                  in the prevention of     by No. 066104 in Sec.
                                                  establishment of           510.600(c) of this
                                                  nodular worm             chapter.
                                                  (Oesophagostomum spp.)
                                                  infections.
(iii) 40 or 100............  ..................  For control of porcine   Feed as the sole                016592
                                                  proliferative            ration 100 g of                054771
                                                  enteropathies            tylosin per ton of             058198
                                                  (ileitis) associated     complete feed for at           066104
                                                  with Lawsonia            least 3 weeks. Follow
                                                  intracellularis.         with 40 grams per ton
                                                                           of complete feed
                                                                           until market weight.
(iv) 40 or 100.............  Pyrantel, 96......  For control of porcine   Feed as the sole                066104
                                                  proliferative            ration 100 g of
                                                  enteropathies            tylosin per ton of
                                                  (ileitis) associated     complete feed for at
                                                  with Lawsonia            least 3 weeks. Follow
                                                  intracellularis; and     with 40 grams per ton
                                                  as an aid in the         of complete feed
                                                  prevention of            until market weight.
                                                  migration and            Tylosin phosphate and
                                                  establishment of large   pyrantel as provided
                                                  roundworm (Ascaris       by No. 066104 in Sec.
                                                  suum) infections; aid      510.600(c) of this
                                                  in the prevention of     chapter.
                                                  establishment of
                                                  nodular worm
                                                  (Oesophagostomum spp.)
                                                  infections.
(v) 40 or 100..............  Ractopamine, 4.5    Finishing swine: For     Feed continuously as            016592
                              to 9.0.             the control of swine     the sole ration to             054771
                                                  dysentery associated     finishing swine                058198
                                                  with Brachyspira         weighing not less
                                                  hyodysenteriae; for      than 150 lbs for the
                                                  control of porcine       last 45 to 90 lbs
                                                  proliferative            (group average) of
                                                  enteropathies            weight gain prior to
                                                  (ileitis) associated     slaughter. Include
                                                  with Lawsonia            100 g/ton of tylosin
                                                  intracellularis; and     for at least 3 weeks,
                                                  for increased rate of    followed by 40 g/ton
                                                  weight gain, improved    until market weight.
                                                  feed efficiency, and     Tylosin phosphate as
                                                  increased carcass        provided by Nos.
                                                  leanness in finishing    058198 and 016592;
                                                  swine weighing not       ractopamine as
                                                  less than 150 lbs, fed   provided by Nos.
                                                  a complete ration        058198 and 054771 in
                                                  containing at least      Sec.   510.600(c) of
                                                  16% crude protein for    this chapter.
                                                  the last 45 to 90 lbs
                                                  of gain prior to
                                                  slaughter.
(vi) 40 to 100.............  ..................  For the treatment and    Administer as tylosin           016592
                                                  control of swine         phosphate in feed              054771
                                                  dysentery associated     continuously as the            058198
                                                  with Brachyspira         sole ration for 2 to           066104
                                                  hyodysenteriae           6 weeks, immediately
                                                  immediately after        after treatment with
                                                  medicating with          tylosin tartrate in
                                                  tylosin in drinking      drinking water for 3
                                                  water.                   to 10 days as in Sec.
                                                                             520.2640(d)(3) of
                                                                           this chapter.
(vii) 40 to 100............  Pyrantel, 96......  For the treatment and    Administer as tylosin           066104
                                                  control of swine         phosphate in feed
                                                  dysentery associated     continuously as the
                                                  with Brachyspira         sole ration for 2 to
                                                  hyodysenteriae           6 weeks, immediately
                                                  immediately after        after treatment with
                                                  medicating with          tylosin tartrate in
                                                  tylosin in drinking      drinking water for 3
                                                  water; and as an aid     to 10 days as in Sec.
                                                  in the prevention of       520.2640(d)(3) of
                                                  migration and            this chapter. Tylosin
                                                  establishment of large   phosphate and
                                                  roundworm (Ascaris       pyrantel as provided
                                                  suum) infections; aid    by No. 066104 in Sec.
                                                  in the prevention of       510.600(c) of this
                                                  establishment of         chapter.
                                                  nodular worm
                                                  (Oesophagostomum spp.)
                                                  infections.
(viii) 40 to 100...........  ..................  For the control of       Administer as tylosin           016592
                                                  porcine proliferative    phosphate in feed              054771
                                                  enteropathies (PPE,      continuously as the            058198
                                                  ileitis) associated      sole ration for 2 to           066104
                                                  with Lawsonia            6 weeks, immediately
                                                  intracellularis          after treatment with
                                                  immediately after        tylosin tartrate in
                                                  medicating with          drinking water for 3
                                                  tylosin in drinking      to 10 days as in Sec.
                                                  water.                     520.2640(d)(3) of
                                                                           this chapter.

(ix) 40 to 100.............  Pyrantel, 96......  For the control of       Administer as tylosin           066104
                                                  porcine proliferative    phosphate in feed
                                                  enteropathies (PPE,      continuously as the
                                                  ileitis) associated      sole ration for 2 to
                                                  with Lawsonia            6 weeks, immediately
                                                  intracellularis          after treatment with
                                                  immediately after        tylosin tartrate in
                                                  medicating with          drinking water for 3
                                                  tylosin in drinking      to 10 days as in Sec.
                                                  water; and as an aid       520.2640(d)(3) of
                                                  in the prevention of     this chapter. Tylosin
                                                  migration and            phosphate and
                                                  establishment of large   pyrantel as provided
                                                  roundworm (Ascaris       by No. 066104 in Sec.
                                                  suum) infections; aid      510.600(c) of this
                                                  in the prevention of     chapter.
                                                  establishment of
                                                  nodular worm
                                                  (Oesophagostomum spp.)
                                                  infections.
(x) 40 to 100..............  Ractopamine, 4.5    Finishing swine: For     Feed continuously as            016592
                              to 9.0.             the treatment and        the sole ration to             054771
                                                  control of swine         finishing swine                058198
                                                  dysentery associated     weighing not less
                                                  with Brachyspira         than 150 lbs for the
                                                  hyodysenteriae, for      last 45 to 90 lbs
                                                  control of porcine       (group average) of
                                                  proliferative            weight gain prior to
                                                  enteropathies (PPE,      slaughter. Include 40
                                                  ileitis) associated      to 100 grams of
                                                  with Lawsonia            tylosin phosphate per
                                                  intracellularis; and     ton of complete feed
                                                  for increased rate of    for 2 to 6 weeks,
                                                  weight gain, improved    immediately after
                                                  feed efficiency, and     treatment with
                                                  increased carcass        tylosin tartrate in
                                                  leanness in finishing    drinking water for 3
                                                  swine weighing not       to 10 days as in Sec.
                                                  less than 150 lbs, fed     520.2640(d)(3) of
                                                  a complete ration        this chapter. Tylosin
                                                  containing at least      phosphate as provided
                                                  16% crude protein for    by Nos. 058198 and
                                                  the last 45 to 90 lbs    016592; ractopamine
                                                  of gain prior to         as provided by Nos.
                                                  slaughter.               058198 and 054771 in
                                                                           Sec.   510.600(c) of
                                                                           this chapter.
(xi) 100...................  ..................  For reduction in         Feed continuously as            016592
                                                  severity of effects of   the sole ration.               054771
                                                  atrophic rhinitis.                                      058198
                                                                                066104
(xii) 100..................  Pyrantel, 96......  For reduction in         Feed continuously as            066104
                                                  severity of effects of   the sole ration.
                                                  atrophic rhinitis; aid   Tylosin phosphate and
                                                  as an aid in the         pyrantel as provided
                                                  prevention of            by No. 066104 in Sec.
                                                  migration and              510.600(c) of this
                                                  establishment of large   chapter. Tylosin
                                                  roundworm (Ascaris       phosphate and
                                                  suum) infections; aid    pyrantel as provided
                                                  in the prevention of     by No. 066104 in Sec.
                                                  establishment of           510.600(c) of this
                                                  nodular worm             chapter.
                                                  (Oesophagostomum spp.)
                                                  infections.
(xiii) 100.................  Ractopamine, 4.5    For the control of       Feed continuously as            016592
                              to 9.0.             porcine proliferative    the sole ration to             054771
                                                  enteropathies (PPE,      finishing swine                058198
                                                  ileitis) associated      weighing not less
                                                  with Lawsonia            than 150 lbs for the
                                                  intracellularis; and     last 45 to 90 lbs
                                                  for increased rate of    (group average) of
                                                  weight gain, improved    weight gain prior to
                                                  feed efficiency, and     slaughter. Include
                                                  increased carcass        100 g/ton of tylosin
                                                  leanness in finishing    for 3 weeks. Tylosin
                                                  swine weighing not       phosphate as provided
                                                  less than 150 lbs, fed   by Nos. 058198 and
                                                  a complete ration        016592; ractopamine
                                                  containing at least      as provided by Nos.
                                                  16% crude protein for    058198 and 054771 in
                                                  the last 45 to 90 lbs    Sec.   510.600(c) of
                                                  of gain prior to         this chapter.
                                                  slaughter.
----------------------------------------------------------------------------------------------------------------

    (2) Cattle--

----------------------------------------------------------------------------------------------------------------
                               Combination in
     Tylosin  grams/ton           grams/ton        Indications for use          Limitations          Sponsors
----------------------------------------------------------------------------------------------------------------
(i) 8 to 10................  ..................  Beef cattle: For         Feed continuously as           016592,
                                                  reduction of incidence   the sole ration to            054771,
                                                  of liver abscesses       provide 60 to 90 mg/   058198, 066104
                                                  caused by                head/day tylosin.
                                                  Fusobacterium
                                                  necrophorum and