UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

Date:		21-Jan-2010

Subject:	Difenoconazole.  Acute and Chronic Aggregate Dietary Exposure and Risk Assessments for the Section 3 Registration Request for Mango and Wax Apple.

PC Code:  	128847	DP Barcode:	371613

Decision No.: 413927	Registration No.:  None

Petition Nos.:  9E7573 	Regulatory Action:  Section 3

Assessment Type:  Single Chemical, Dietary 	Registration Case No.:  NA

TXR No.:  None	CAS No.:  119446-68-3

MRID No.:  None	40 CFR: 180.475

Reviewer:	Thurston G. Morton, Chemist

Risk Assessment Branch IV/Health Effects Division (RABIV/HED; 7509P)

Through:	Doug Dotson, PhD., Chemist

Julie Van Alstine, MPH, Environmental Health Scientist

Dietary Exposure Science Advisory Council (DESAC)

	And

Susan V. Hummel, Senior Chemist

RABIV/HED (7509P)

To:			Yan Donovan, Risk Assessor

RABIV/HED (7509P)

	And

Tony Kish

Fungicide Branch/RD (7505P)

Executive Summary

Aggregate (food + water) acute and chronic dietary risk assessments were conducted using the Dietary Exposure Evaluation Model - Food Consumption Intake Database (DEEM-FCID(, ver. 2.03).  This model uses food consumption data from the United States Department of Agriculture’s (USDA’s) Continuing Surveys of Food Intakes by Individuals (CSFII; 1994-1996 and 1998).  The analyses were performed to support a Section 3 request for new uses of the fungicide difenoconazole [1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-ylmet hyl]-1H-1,2,4-triazole] in/on mango and wax apple.

The unrefined acute analysis assumed tolerance-level residues, 100% crop treated (CT), and the available empirical or DEEM( (ver. 7.81) default processing factors.  The resulting acute food exposure estimates were less than HED’s level of concern (<100% of the acute population-adjusted dose (aPAD)) at the 95th percentile of the exposure distribution for the general U.S. population (7 % aPAD) and all population sub-groups; the most highly exposed population subgroup was children1-2 years old with 16 % aPAD.  The somewhat refined chronic analysis assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, the available empirical or DEEM( (ver. 7.81) default processing factors, and 100 % CT.  The resulting chronic food exposure estimates were less than HED’s level of concern (<100% of the chronic population-adjusted dose (cPAD)) for the general U.S. population (17 % cPAD) and all population sub-groups; the most highly exposed population subgroup was children 1-2 years old with 45 % cPAD.

The requested uses of difenoconazole did not result in an increase in dietary exposure estimates for free triazole or conjugated triazoles.  Therefore, the last dietary exposure analyses for the triazole metabolites (M. Negussie, 28 Oct. 2009) have not changed.

I.   Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the PAD.  The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  HED is generally concerned when estimated cancer risk exceeds one in one million.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link:      HYPERLINK "http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf"  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for difenoconazole was conducted by T. Morton (22-September-2009; DP#367383).

II.   Residue Information

Difenoconazole tolerances are published in 40 CFR§180.475.

Residues of Concern in Plants and Livestock:   The HED Metabolism Assessment Review Committee (MARC) has determined that for tolerance expression and risk assessment purposes, the residue of concern is difenoconazole per se for plant and livestock commodities.  The MARC, however, stated that if tolerances are proposed for difenoconazole resulting from foliar uses which result in higher residue levels of CGA-205375 than parent, then the need to include CGA-205375 should be reconsidered (Memo, G. Kramer, 22-JUL-1994; No DP#).  Because the petitioner has now proposed foliar uses of difenoconazole, which result in higher residues in crop commodities, the need to include metabolite CGA 205375 in the tolerance expression and/or risk assessment has been re-examined.  Based upon a review of the previously-submitted metabolism data for difenoconazole, HED concludes the residue of concern for both tolerance setting and risk assessment for the crops included in this petition is difenoconazole.  However, HED concludes the residue of concern in livestock for tolerance setting and risk assessment are difenoconazole and its metabolite CGA 205375 (for more details, see the summary document, DP# 340379).  Table 1 below summarizes tolerance expression and the residues of concern in plant and livestock commodities.

Table 1.  Difenoconazole Residues of Concern in Plants and Ruminants.

Matrix

Residues of Concern

For Risk Assessment

For Tolerance Expression

Plants	Primary and Rotational crops

Parent Only

Parent Only

Livestock	Ruminant and Poultry

Parent and CGA 205375

Parent and CGA 205375

Drinking Water

Parent Only

NA

Recommended Tolerances:  Based on the residue chemistry data submitted with the current petitions, HED recommended for establishment of the new food tolerances (DP# 366507, B. Cropp-Kohlligian, 21-Jan-2010).  The recommended, established, and revised tolerances are listed in Table 2 below.

Table 2.  Tolerance Summary for Difenoconazole.

Commodity	Existing/Established Tolerances (ppm)	New Recommended Tolerances (ppm)

Almond, nutmeat1	0.05	0.03 tree nut

Almond, hulls1	5.0	7.0

Brassica subgroup 5A	none	1.9

Brassica subgroup 5B	none	35

Citrus, dried pulp	none	2.5

Citrus oil	none	25

Fruit, citrus, group 10	none	0.6

Grape	0.1	4.0

Grape, raisin	none	6.0

Nut, tree, group 14	none	0.03

Onion, bulb, subgroup 3—07A	none	0.20

Onion, green, subgroup 3—07B	none	6.0

Pistachios	none	0.03

Vegetable, cucurbit, group 91	1.0 individual RACs	0.7

Fruit, Pome, group 11	1.0	------

Vegetable, Fruiting, Group 8	0.60	------

Vegetable, Tuberous and Corm, subgroup 1C	0.01	------

Beet, sugar2	0.30	------

Papaya	0.30	------

Apple, wet pomace	4.5	------

Beet, sugar, dried pulp	1.9	------

Potato, processed waste	0.04	------

Banana	0.2	------

Barley, grain	0.1	------

Barley, hay	0.05	------

Barley, straw	0.05	------

Canola, seed	0.01	------

Cattle fat	0.10	------

Cattle, meat	0.05	------

Cattle, meat byproducts	0.10	------

Cattle, liver	0.20	------

Corn, sweet, forage	0.01	------

Corn, sweet, kernel plus cob with husks removed	0.01	------

Corn, sweet, stover	0.01	------

Cotton, gin byproducts	0.05	------

Cotton, undelinted seed	0.05	------

Egg3	0.10	------

Goat, fat	0.10	------

Goat, meat	0.05	------

Goat, meat byproducts (except liver)	0.10	------

Goat, liver	0.20	------

Hog, fat	0.10	------

Hog, meat	0.05	------

Hog, meat byproducts (except liver)	0.1	------

Hog, liver	0.20	------

Horse, fat	0.10	------

Horse, meat	0.05	------

Horse, meat byproducts (except liver)	0.10	------

Horse, liver	0.20	------

Milk	0.01	------

Rye, grain	0.1	------

Sheep, fat	0.10	------

Sheep, meat	0.05	------

Sheep, meat byproducts (except liver)	0.10	------

Sheep, liver	0.20	------

Wheat, forage	0.1	------

Wheat, grain	0.1	------

Wheat, straw	0.1	------

Wax apple	None	0.07

Mango	None	0.07

1 Section 18 emergency exemption tolerance.

2 The registered tolerance on sugar beet (0.01 ppm) needs to be changed to 0.3 ppm; see “Notes to RD” in memorandum: M. Sahafeyan, D351715, 07-MAY-08.

3 Based on a feeding study, HED recommended the tolerances for poultry commodities (except egg) be removed and the egg tolerance be increased to the current level of 0.1 ppm.

The requested uses of difenoconazole did not result in an increase in dietary exposure estimates for free triazole or conjugated triazoles.  Therefore, the last dietary exposure analyses for the triazole metabolites (M. Negussie, 28 Oct. 2009) have not changed.

Food Residues and processing factors used in the Acute and Chronic Analysis:  The acute analysis assumed tolerance-level residues and 100% CT for all the registered and proposed crops.  Tolerance-level residues were also assumed for all livestock tissues in this assessment.  The chronic analysis assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, and 100 % CT.  Those commodities where field trial data were used are summarized below.  HED SOP 2000.1 Guidance for Translation of Field Trial Data from Representative Commodities in the Crop Group Regulation to Other Commodities in Each Crop Group/Subgroup dated 9/12/2000 was used in translating to other commodities in the crop group.  Experimental processing factors were used for apple juice (0.04x), grape juice (0.2x), citrus juices (0.1x), potato chips (0.5x), potato granules/flakes (0.5x), raisin (3.5x chronic only), sugar beet molasses (0.6x), tomato paste (1.6x), and tomato puree (0.5x); DEEM( (ver. 7.81) default processing factors were assumed for other processed commodities.

No free triazole or conjugated triazole residue data were submitted with the mango residue field trial submission.  However, current dietary exposure estimates  are conservative enough that submission of this residue data on mango is not expected to result in an increase in aggregate exposure.

Almond: Field trial residues were used from MRID 47586101.

Apple: Field trial residues were used from MRID 46950233.

Broccoli: Field trial residues were used from MRID 47586102.  Residues from 1-7 day PHI were used since registered labels allow from 1-7 day PHIs.

Cabbage:  Field trial residues were used from 47586102.  Residues from 1-7 day PHI were used since registered labels allow from 1-7 day PHIs.  To refine the dietary exposure data from only cabbage samples without wrapper leaves were used.

Cantaloupe: Field trial residues were used from MRID 47586103.  Residues from 0-1 day PHI were used since registered labels allow from 0-1 day PHI.

Cucumber: Field trial residues were used from MRID 47586103.  Residues from 0-1 day PHI were used since registered labels allow from 0-1 day PHI.

Grape: Field trial residues were used from MRID 47586105.

Grapefruit: Field trial residues were used from MRID 47586104.

Leaf Lettuce: Field trial residues were used from MRIDs 47417703 and 47417706.

Lemon: Field trial residues were used from MRID 47586104.

Lime: Field trial residues were used from MRID 47586104.

Mustard Greens: Field trial residues were used from MRIDs 47417704, 47417707, and 47586102.  Residues from 1-7 day PHI were used since registered labels allow from 1-7 day PHIs.

Orange: Field trial residues were used from MRID 47586104.

Pear: Field trial residues were used from MRID 46950233.

Pecan: Field trial residues were used from MRID 47586106.

Peppers: Field trial residues were used from MRID 46950234.

Potato: Field trial residues were used from MRID 46950235.

Sugar Beet: Field trial residues were used from MRID 46950236.

Summer Squash: Field trial residues were used from MRID 47586103.  Residues from 0-1 day PHI were used since registered labels allow from 0-1 day PHIs.

Tomato: Field trial residues were used from MRIDs 46950234, 47417705, and 47417708.

  Drinking Water Data

The drinking water estimates used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED; Memo, I. Maher, 28-MAY-2009; D361398).  EFED conducted a Tier II drinking water assessment for surface water sources using the Pesticide Root Zone/Exposure Analysis Modeling System (PRZM/EXAMS) for the registered and proposed new uses.  Among all the registered and proposed new uses, the highest estimated drinking water concentrations (EDWCs) for surface water sources were derived for aerial applications of difenoconazole to New York grapes at the maximum annual application rate of 0.46 lb ai/acre. The estimated drinking water residues for 1-in-10 year annual peak, 1-in-10 year annual mean, and 36-year annual mean are 15.8, 10.4, and 7.62 μg/L (ppb) respectively.

μg/L (ppb)  was used for the acute dietary exposure analysis and the 1-in-10 year annual mean EDWC of 10.4 μg/L (ppb) was used for the chronic dietary exposure analysis.

IV.   DEEM-FCID( Program and Consumption Information

Difenoconazole acute and chronic dietary exposure assessments were conducted using the DEEM-FCID( (ver. 2.03), which incorporates consumption data from USDA’s CSFII (1994-1996 and 1998).  The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups:  the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form.  The resulting residue consumption estimate for each food/food form is summed with the residue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, for Tiers 1 and 2, significant differences in user vs. per capita exposure and risk are identified and noted in the risk assessment.

V.   Toxicological Information

On 08-SEP-1998, HED’s Hazard Identification Assessment Review Committee (HIARC) evaluated the toxicology database of difenoconazole and re-assessed the RfD established in 1994, as well as the toxicological endpoints for the dietary and occupational exposure risk assessments that were selected in 1994.  At this meeting, the HIARC also addressed the potential enhanced sensitivity of infants and children from exposure to difenoconazole as required by the Food Quality Protection Act (FQPA) of 1996 (HED Doc. No. 012873, 25-SEP-1998).  In July, 2007, the RAB1 toxicologists and risk assessment team met to reevaluate the endpoints selected by the HIARC since new studies were submitted.  RAB1 toxicologists and risk assessment team also reevaluated FQPA assessments.  The risk assessment team concluded that the default 10x FQPA Safety Factor (SF) should be reduced to 1x when assessing acute and chronic dietary exposures (M.Sahafeyan, D333320, 09-AUG-07).  The relevant endpoints are shown in Table 3.

For purposes of this action, HED recently reviewed HED’s 27-JUL-1994 Cancer Peer Review Committee (CPRC) report (Memo, Jess Rowland and Esther Rinde) on difenoconazole and the supporting data-evaluation records (DERs).  HED concluded that difenoconazole is a very weak carcinogen, showing effects only at excessive doses.  In retrospect, the CPRC should have classified this pesticide as a category C with no linear quantification of cancer risk.  The cRfD, based on borderline liver effects in male rats at 24.1 mg/kg and a NOAEL of 0.96 mg/kg, is protective of any carcinogenic effects seen in the mouse (Memo, S. Levy et al., 05-AUG-2005; DP# 319944).  Therefore, a separate cancer dietary assessment is not being conducted for difenoconazole.

Table 3.  Summary of Toxicological Doses and Endpoints for Difenoconazole for Use in Dietary Risk Assessments.

Exposure Scenario	Point of Departure	Uncertainty/FQPA Safety Factors RfD, PAD, for Risk Assessment	Study and Relevant Toxicological Effects

Acute Dietary (All populations)	NOAEL = 25

mg/kg	UFA = 10X

UFH = 10X

FQPA SF = 1X 	aRfD = aPAD = 0.25 mg/kg/day	Acute Neurotoxicity Study in Rats

LOAEL= 200 mg/kg in males based on reduced fore-limb grip strength in males on day 1.

Chronic Dietary (All populations)	NOAEL = 0.96

mg/kg/day	UFA = 10X

UFH = 10X

FQPA SF = 1X	cRfD = cPAD = 0.01mg/kg/day	Combined chronic toxicity/carcinogenicity (rat; dietary) LOAEL = 24.1/32.8 mg/kg/day (M/F) based on cumulative decreases in body-weight gains.

Cancer (oral, dermal, inhalation)	Difenoconazole is classified as a Group C, possible human carcinogen with a non-linear (MOE) approach for human risk characterization (CPRC Document, 7/27/94, Memo, P. V. Shah dated March 3, 2007, HED Doc. No. 0054532). The chronic dietary exposure assessment is protective of cancer effects.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and  used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures.  NOAEL = no observed adverse effect level.  LOAEL = lowest observed adverse effect level.  UF = uncertainty factor.  UFA = extrapolation from animal to human (interspecies).  UFH = potential variation in sensitivity among members of the human population (intraspecies).  FQPA SF = FQPA Safety Factor.  PAD = population adjusted dose (a = acute, c = chronic).  RfD = reference dose.

VI.   Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the aPAD or cPAD, respectively.  The following paragraphs are summaries of the DEEM-FCID( (ver. 2.03) acute and chronic exposure analyses.

Acute and chronic aggregate (food + water) analyses were performed using DEEM-FCID( estimating the dietary exposure of the U.S. population and various population subgroups.  The results are summarized in Tables 4 and 5 below for acute and chronic analyses respectively.

The resulting acute food exposure estimates were less than HED’s level of concern (<100% aPAD) at the 95th percentile of the exposure distribution for general US population (7 % aPAD) and all population sub-groups; the most highly exposed population subgroup was Children 1-2 years old with 16 % aPAD.  The resulting chronic food exposure estimates were less than HED’s level of concern (<100% cPAD) for the general U.S. population (17 % cPAD) and all population sub-groups; the most highly exposed population subgroup was children 1-2 years old with 45 % cPAD.   A cancer dietary assessment was not conducted for difenoconazole because the cancer NOAEL is higher than the chronic RfD; therefore, the chronic dietary risk estimate is more protective.

Table 4.  Summary of Acute Dietary Exposure and Risk for Difenoconazole at the 95th Percentile.

Population Subgroup

aPAD (mg/kg/day)

Exposure (mg/kg/day)

%aPAD

General U.S. Population

0.25

0.017747	7

All Infants (< 1 year old)

0.0255139	10

Children 1-2 years old

0.039565	16

Children 3-5 years old

0.031818	13

Children 6-12 years old

0.017949	7

Youth 13-19 years old

0.008828	4

Adults 20-49 years old

0.013083	5

Adults 50+ years old

0.017255	7

Females 13-49 years old

0.013281	5

The bolded %aPAD is the highest.

Table 5.  Summary of Chronic Dietary Exposure and Risk for Difenoconazole.

Population Subgroup

cPAD (mg/kg/day)

Exposure (mg/kg/day)

%cPAD

General U.S. Population

0.01

0.001709	17

All Infants (< 1 year old)

0.002445	25

Children 1-2 years old

0.004484	45

Children 3-5 years old

0.003624	36

Children 6-12 years old

0.002061	21

Youth 13-19 years old

0.001372	14

Adults 20-49 years old

0.001376	14

Adults 50+ years old

0.001548	16

Females 13-49 years old

0.001402	14

The bolded %cPAD is the highest.

VII.   Characterization of Inputs/Outputs

The acute analysis assumed tolerance-level residues, 100% CT, and empirical or DEEM( default processing factors.  The chronic analysis assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, 100 % CT, and empirical or DEEM( default processing factors.  Therefore, these analyses are considered conservative.  They do not warrant the need for further refinement at this time.

VIII.   Conclusions

An acute aggregate (food + water) dietary risk assessment was conducted for difenoconazole using the DEEM-FCID( (ver. 2.03) Model and assumed tolerance-level residues, 100% CT, and empirical or DEEM( default processing factors.  The chronic aggregate dietary risk assessment assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, 100 % CT, and empirical or DEEM( default processing factors.  The resulting acute and chronic aggregate exposure estimates were less than HED’s level of concern.  For the general U.S. population, the aPAD and cPAD were 7 % and 17 %, respectively.  The most highly-exposed population subgroups in the acute (at the 95th percentile of the exposure distribution) and chronic analyses were Children 1-2 years old (16 % aPAD) and children 1-2 years old (45 % cPAD), respectively.

IX.   Attachments

Attachment 1:	DEEM-FCID( Acute Residue File

Attachment 2:	DEEM-FCID( Acute Exposure Estimates

Attachment 3:	DEEM-FCID( Chronic Residue File

Attachment 4:	DEEM-FCID( Chronic Exposure Estimates

cc with all attachments:  T. Morton (RABIV)

RDI: D. Dotson and J.Van Alstine - DESAC (7-Jan-2010); S. Hummel (21-Jan-2010)

Petition Number(s): PP#8F7482

DP#: 371613

PC Code: 128847

T. Morton:S10922:PY1:(703)305-6691

Attachment 1:  DEEM-FCID( Acute Residue File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 DifenocozoleNew Uses of Wax Apple and Mango\difenoconazole_acute-01-10.R98

Chemical: Difenoconazole

RfD(Chronic): .01 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 01-12-2010/10:30:55/8          Program ver. 2.03

------------------------------------------------------------------------ --------

  EPA    Crop                                   Def Res     Adj.Factors   Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2

-------- ---- -------------------------------  ----------  ------ ------  -------

95000230 O    Banana                             0.200000   1.000  1.000

95000231 O    Banana-babyfood                    0.200000   1.000  1.000

95000240 O    Banana, dried                      0.200000   3.900  1.000

95000241 O    Banana, dried-babyfood             0.200000   3.900  1.000

95001280 O    Cottonseed, oil                    0.050000   1.000  1.000

95001281 O    Cottonseed, oil-babyfood           0.050000   1.000  1.000

95001750 O    Grape                              4.000000   1.000  1.000

95001760 O    Grape, juice                       4.000000   0.200  1.000

95001761 O    Grape, juice-babyfood              4.000000   0.200  1.000

95001770 O    Grape, leaves                      4.000000   1.000  1.000

95001780 O    Grape, raisin                      6.000000   1.000  1.000

95001790 O    Grape, wine and sherry             4.000000   1.000  1.000

95002150 O    Mango                              0.070000   1.000  1.000

95002151 O    Mango-babyfood                     0.070000   1.000  1.000

95002160 O    Mango, dried                       0.070000   1.000  1.000

95002170 O    Mango, juice                       0.070000   1.000  1.000

95002171 O    Mango, juice-babyfood              0.070000   1.000  1.000

95002450 O    Papaya                             0.300000   1.000  1.000

95002451 O    Papaya-babyfood                    0.300000   1.000  1.000

95002460 O    Papaya, dried                      0.300000   1.800  1.000

95002470 O    Papaya, juice                      0.300000   1.500  1.000

95002830 O    Plantain                           0.200000   1.000  1.000

95002840 O    Plantain, dried                    0.200000   3.900  1.000

86010000 O    Water, direct, all sources         0.015800   1.000  1.000

86020000 O    Water, indirect, all sources       0.015800   1.000  1.000

21000440 M    Beef, meat                         0.050000   1.000  1.000

21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000

21000450 M    Beef, meat, dried                  0.050000   1.920  1.000

21000460 M    Beef, meat byproducts              0.100000   1.000  1.000

21000461 M    Beef, meat byproducts-babyfood     0.100000   1.000  1.000

21000470 M    Beef, fat                          0.100000   1.000  1.000

21000471 M    Beef,fat-babyfood                  0.100000   1.000  1.000

21000480 M    Beef, kidney                       0.100000   1.000  1.000

21000490 M    Beef, liver                        0.200000   1.000  1.000

21000491 M    Beef, liver-babyfood               0.200000   1.000  1.000

23001690 M    Goat, meat                         0.050000   1.000  1.000

23001700 M    Goat, meat byproducts              0.100000   1.000  1.000

23001710 M    Goat, fat                          0.100000   1.000  1.000

23001720 M    Goat, kidney                       0.100000   1.000  1.000

23001730 M    Goat, liver                        0.200000   1.000  1.000

24001890 M    Horse, meat                        0.050000   1.000  1.000

25002900 M    Pork, meat                         0.050000   1.000  1.000

25002901 M    Pork, meat-babyfood                0.050000   1.000  1.000

25002910 M    Pork, skin                         0.100000   1.000  1.000

25002920 M    Pork, meat byproducts              0.100000   1.000  1.000

25002921 M    Pork, meat byproducts-babyfood     0.100000   1.000  1.000

25002930 M    Pork, fat                          0.100000   1.000  1.000

25002931 M    Pork, fat-babyfood                 0.100000   1.000  1.000

25002940 M    Pork, kidney                       0.100000   1.000  1.000

25002950 M    Pork, liver                        0.200000   1.000  1.000

26003390 M    Sheep, meat                        0.050000   1.000  1.000

26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000

26003400 M    Sheep, meat byproducts             0.100000   1.000  1.000

26003410 M    Sheep, fat                         0.100000   1.000  1.000

26003411 M    Sheep, fat-babyfood                0.100000   1.000  1.000

26003420 M    Sheep, kidney                      0.100000   1.000  1.000

26003430 M    Sheep, liver                       0.200000   1.000  1.000

70001450 P    Egg, whole                         0.100000   1.000  1.000

70001451 P    Egg, whole-babyfood                0.100000   1.000  1.000

70001460 P    Egg, white                         0.100000   1.000  1.000

70001461 P    Egg, white (solids)-babyfood       0.100000   1.000  1.000

70001470 P    Egg, yolk                          0.100000   1.000  1.000

70001471 P    Egg, yolk-babyfood                 0.100000   1.000  1.000

27002220 D    Milk, fat                          0.010000   1.000  1.000

27002221 D    Milk, fat - baby food/infant for   0.010000   1.000  1.000

27012230 D    Milk, nonfat solids                0.010000   1.000  1.000

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000  1.000

27022240 D    Milk, water                        0.010000   1.000  1.000

27022241 D    Milk, water-babyfood/infant form   0.010000   1.000  1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000  1.000

01010520 1A   Beet, sugar                        0.300000   1.000  1.000

01010521 1A   Beet, sugar-babyfood               0.300000   1.000  1.000

01010530 1A   Beet, sugar, molasses              0.300000   0.600  1.000

01010531 1A   Beet, sugar, molasses-babyfood     0.300000   0.600  1.000

01032960 1C   Potato, chips                      0.010000   0.500  1.000

01032970 1C   Potato, dry (granules/ flakes)     0.010000   0.500  1.000

01032971 1C   Potato, dry (granules/ flakes)-b   0.010000   0.500  1.000

01032980 1C   Potato, flour                      0.010000   0.500  1.000

01032981 1C   Potato, flour-babyfood             0.010000   0.500  1.000

01032990 1C   Potato, tuber, w/peel              0.010000   1.000  1.000

01032991 1C   Potato, tuber, w/peel-babyfood     0.010000   1.000  1.000

01033000 1C   Potato, tuber, w/o peel            0.010000   1.000  1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.010000   1.000  1.000

03001640 3    Garlic                             0.200000   1.000  1.000

03001650 3    Garlic, dried                      0.200000   1.000  1.000

03001651 3    Garlic, dried-babyfood             0.200000   1.000  1.000

03001980 3    Leek                               6.000000   1.000  1.000

03002370 3    Onion, dry bulb                    0.200000   1.000  1.000

03002371 3    Onion, dry bulb-babyfood           0.200000   1.000  1.000

03002380 3    Onion, dry bulb, dried             0.200000   9.000  1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.200000   9.000  1.000

03002390 3    Onion, green                       6.000000   1.000  1.000

03003380 3    Shallot                            0.200000   1.000  1.000

05010610 5A   Broccoli                           1.900000   1.000  1.000

05010611 5A   Broccoli-babyfood                  1.900000   1.000  1.000

05010620 5A   Broccoli, Chinese                  1.900000   1.000  1.000

05020630 5B   Broccoli raab                     35.000000   1.000  1.000

05010640 5A   Brussels sprouts                   1.900000   1.000  1.000

05010690 5A   Cabbage                            1.900000   1.000  1.000

05020700 5B   Cabbage, Chinese, bok choy        35.000000   1.000  1.000

05010710 5A   Cabbage, Chinese, napa             1.900000   1.000  1.000

05010720 5A   Cabbage, Chinese, mustard          1.900000   1.000  1.000

05010830 5A   Cauliflower                        1.900000   1.000  1.000

05021170 5B   Collards                          35.000000   1.000  1.000

05021940 5B   Kale                              35.000000   1.000  1.000

05011960 5A   Kohlrabi                           1.900000   1.000  1.000

05022290 5B   Mustard greens                    35.000000   1.000  1.000

05023180 5B   Rape greens                       35.000000   1.000  1.000

05023890 5B   Turnip, greens                    35.000000   1.000  1.000

08001480 8    Eggplant                           0.600000   1.000  1.000

08002340 8    Okra                               0.600000   1.000  1.000

08002700 8    Pepper, bell                       0.600000   1.000  1.000

08002701 8    Pepper, bell-babyfood              0.600000   1.000  1.000

08002710 8    Pepper, bell, dried                0.600000   1.000  1.000

08002711 8    Pepper, bell, dried-babyfood       0.600000   1.000  1.000

08002720 8    Pepper, nonbell                    0.600000   1.000  1.000

08002721 8    Pepper, nonbell-babyfood           0.600000   1.000  1.000

08002730 8    Pepper, nonbell, dried             0.600000   1.000  1.000

08003740 8    Tomatillo                          0.600000   1.000  1.000

08003750 8    Tomato                             0.600000   1.000  1.000

08003751 8    Tomato-babyfood                    0.600000   1.000  1.000

08003760 8    Tomato, paste                      0.600000   1.600  1.000

08003761 8    Tomato, paste-babyfood             0.600000   1.600  1.000

08003770 8    Tomato, puree                      0.600000   0.500  1.000

08003771 8    Tomato, puree-babyfood             0.600000   0.500  1.000

08003780 8    Tomato, dried                      0.600000  14.300  1.000

08003781 8    Tomato, dried-babyfood             0.600000  14.300  1.000

08003790 8    Tomato, juice                      0.600000   1.500  1.000

09020210 9B   Balsam pear                        0.700000   1.000  1.000

09010750 9A   Cantaloupe                         0.700000   1.000  1.000

09010800 9A   Casaba                             0.700000   1.000  1.000

09020880 9B   Chayote, fruit                     0.700000   1.000  1.000

09021020 9B   Chinese waxgourd                   0.700000   1.000  1.000

09021350 9B   Cucumber                           0.700000   1.000  1.000

09011870 9A   Honeydew melon                     0.700000   1.000  1.000

09023080 9B   Pumpkin                            0.700000   1.000  1.000

09023090 9B   Pumpkin, seed                      0.700000   1.000  1.000

09023560 9B   Squash, summer                     0.700000   1.000  1.000

09023561 9B   Squash, summer-babyfood            0.700000   1.000  1.000

09023570 9B   Squash, winter                     0.700000   1.000  1.000

09023571 9B   Squash, winter-babyfood            0.700000   1.000  1.000

09013990 9A   Watermelon                         0.700000   1.000  1.000

09014000 9A   Watermelon, juice                  0.700000   1.000  1.000

10001060 10   Citrus citron                      0.600000   1.000  1.000

10001070 10   Citrus hybrids                     0.600000   1.000  1.000

10001080 10   Citrus, oil                       25.000000   1.000  1.000

10001800 10   Grapefruit                         0.600000   1.000  1.000

10001810 10   Grapefruit, juice                  0.600000   0.100  1.000

10001970 10   Kumquat                            0.600000   1.000  1.000

10001990 10   Lemon                              0.600000   1.000  1.000

10002000 10   Lemon, juice                       0.600000   0.100  1.000

10002001 10   Lemon, juice-babyfood              0.600000   0.100  1.000

10002010 10   Lemon, peel                        0.600000   1.000  1.000

10002060 10   Lime                               0.600000   1.000  1.000

10002070 10   Lime, juice                        0.600000   0.100  1.000

10002071 10   Lime, juice-babyfood               0.600000   0.100  1.000

10002400 10   Orange                             0.600000   1.000  1.000

10002410 10   Orange, juice                      0.600000   0.100  1.000

10002411 10   Orange, juice-babyfood             0.600000   0.100  1.000

10002420 10   Orange, peel                       0.600000   1.000  1.000

10003070 10   Pummelo                            0.600000   1.000  1.000

10003690 10   Tangerine                          0.600000   1.000  1.000

10003700 10   Tangerine, juice                   0.600000   0.100  1.000

11000070 11   Apple, fruit with peel             1.000000   1.000  1.000

11000080 11   Apple, peeled fruit                1.000000   1.000  1.000

11000081 11   Apple, peeled fruit-babyfood       1.000000   1.000  1.000

11000090 11   Apple, dried                       1.000000   8.000  1.000

11000091 11   Apple, dried-babyfood              1.000000   8.000  1.000

11000100 11   Apple, juice                       1.000000   0.040  1.000

11000101 11   Apple, juice-babyfood              1.000000   0.040  1.000

11000110 11   Apple, sauce                       1.000000   1.000  1.000

11000111 11   Apple, sauce-babyfood              1.000000   1.000  1.000

11001290 11   Crabapple                          1.000000   1.000  1.000

11002100 11   Loquat                             1.000000   1.000  1.000

11002660 11   Pear                               1.000000   1.000  1.000

11002661 11   Pear-babyfood                      1.000000   1.000  1.000

11002670 11   Pear, dried                        1.000000   6.250  1.000

11002680 11   Pear, juice                        1.000000   1.000  1.000

11002681 11   Pear, juice-babyfood               1.000000   1.000  1.000

11003100 11   Quince                             1.000000   1.000  1.000

14000030 14   Almond                             0.030000   1.000  1.000

14000031 14   Almond-babyfood                    0.030000   1.000  1.000

14000040 14   Almond, oil                        0.030000   1.000  1.000

14000041 14   Almond, oil-babyfood               0.030000   1.000  1.000

14000590 14   Brazil nut                         0.030000   1.000  1.000

14000680 14   Butternut                          0.030000   1.000  1.000

14000810 14   Cashew                             0.030000   1.000  1.000

14000920 14   Chestnut                           0.030000   1.000  1.000

14001550 14   Filbert                            0.030000   1.000  1.000

14001560 14   Filbert, oil                       0.030000   1.000  1.000

14001850 14   Hickory nut                        0.030000   1.000  1.000

14002130 14   Macadamia nut                      0.030000   1.000  1.000

14002690 14   Pecan                              0.030000   1.000  1.000

14002820 14   Pistachio                          0.030000   1.000  1.000

14003910 14   Walnut                             0.030000   1.000  1.000

15000250 15   Barley, pearled barley             0.100000   1.000  1.000

15000251 15   Barley, pearled barley-babyfood    0.100000   1.000  1.000

15000260 15   Barley, flour                      0.100000   1.000  1.000

15000261 15   Barley, flour-babyfood             0.100000   1.000  1.000

15000270 15   Barley, bran                       0.100000   1.000  1.000

15001270 15   Corn, sweet                        0.010000   1.000  1.000

15001271 15   Corn, sweet-babyfood               0.010000   1.000  1.000

15003280 15   Rye, grain                         0.100000   1.000  1.000

15003290 15   Rye, flour                         0.100000   1.000  1.000

15004010 15   Wheat, grain                       0.100000   1.000  1.000

15004011 15   Wheat, grain-babyfood              0.100000   1.000  1.000

15004020 15   Wheat, flour                       0.100000   1.000  1.000

15004021 15   Wheat, flour-babyfood              0.100000   1.000  1.000

15004030 15   Wheat, germ                        0.100000   1.000  1.000

15004040 15   Wheat, bran                        0.100000   1.000  1.000

Attachment 2:  DEEM-FCID( Acute Exposure Estimates

U.S. Environmental Protection Agency                                  Ver. 2.02

DEEM-FCID ACUTE Analysis for DIFENOCONAZOLE                      (1994-98 data)

Residue file: difenoconazole_acute-01-10.R98          Adjustment factor #2 used.

Analysis Date: 01-12-2010/14:29:03    Residue file dated: 01-12-2010/14:23:34/8

Daily totals for food and foodform consumption used.

Run Comment: ""

======================================================================== =======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure   % aRfD

                  ---------- --------  ---------- --------  ---------- --------

U.S. Population:

                    0.017747     7.10    0.051415    20.57    0.142474    56.99

All infants:

                    0.025139    10.06    0.040570    16.23    0.118410    47.36

Children 1-2 yrs:

                    0.039565    15.83    0.087361    34.94    0.251716   100.69

Children 3-5 yrs:

                    0.031818    12.73    0.070329    28.13    0.373423   149.37

Children 6-12 yrs:

                    0.017949     7.18    0.038892    15.56    0.148702    59.48

Youth 13-19 yrs:

                    0.008828     3.53    0.039549    15.82    0.137882    55.15

Adults 20-49 yrs:

                    0.013083     5.23    0.041933    16.77    0.109522    43.81

Adults 50+ yrs:

                    0.017255     6.90    0.062629    25.05    0.138639    55.46

Females 13-49 yrs:

                    0.013281     5.31    0.042028    16.81    0.116292    46.52

Attachment 3:  DEEM-FCID( Chronic Residue File

  Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 DifenocozoleNew Uses of Wax Apple and Mango\difenoconazole_chronic-01-10AverageFT.R98

Chemical: Difenoconazole

RfD(Chronic): .01 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 01-12-2010/10:31:20/8          Program ver. 2.03

------------------------------------------------------------------------ --------

  EPA    Crop                                   Def Res     Adj.Factors   Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2

-------- ---- -------------------------------  ----------  ------ ------  -------

95000230 O    Banana                             0.200000   1.000  1.000

95000231 O    Banana-babyfood                    0.200000   1.000  1.000

95000240 O    Banana, dried                      0.200000   3.900  1.000

95000241 O    Banana, dried-babyfood             0.200000   3.900  1.000

95001280 O    Cottonseed, oil                    0.050000   1.000  1.000

95001281 O    Cottonseed, oil-babyfood           0.050000   1.000  1.000

95001750 O    Grape                              0.613000   1.000  1.000

95001760 O    Grape, juice                       0.613000   0.200  1.000

95001761 O    Grape, juice-babyfood              0.613000   0.200  1.000

95001770 O    Grape, leaves                      0.613000   1.000  1.000

95001780 O    Grape, raisin                      0.613000   3.500  1.000

95001790 O    Grape, wine and sherry             0.613000   1.000  1.000

95002150 O    Mango                              0.070000   1.000  1.000

95002151 O    Mango-babyfood                     0.070000   1.000  1.000

95002160 O    Mango, dried                       0.070000   1.000  1.000

95002170 O    Mango, juice                       0.070000   1.000  1.000

95002171 O    Mango, juice-babyfood              0.070000   1.000  1.000

95002450 O    Papaya                             0.300000   1.000  1.000

95002451 O    Papaya-babyfood                    0.300000   1.000  1.000

95002460 O    Papaya, dried                      0.300000   1.800  1.000

95002470 O    Papaya, juice                      0.300000   1.500  1.000

95002830 O    Plantain                           0.200000   1.000  1.000

95002840 O    Plantain, dried                    0.200000   3.900  1.000

86010000 O    Water, direct, all sources         0.010400   1.000  1.000

86020000 O    Water, indirect, all sources       0.010400   1.000  1.000

21000440 M    Beef, meat                         0.050000   1.000  1.000

21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000

21000450 M    Beef, meat, dried                  0.050000   1.920  1.000

21000460 M    Beef, meat byproducts              0.100000   1.000  1.000

21000461 M    Beef, meat byproducts-babyfood     0.100000   1.000  1.000

21000470 M    Beef, fat                          0.100000   1.000  1.000

21000471 M    Beef,fat-babyfood                  0.100000   1.000  1.000

21000480 M    Beef, kidney                       0.100000   1.000  1.000

21000490 M    Beef, liver                        0.200000   1.000  1.000

21000491 M    Beef, liver-babyfood               0.200000   1.000  1.000

23001690 M    Goat, meat                         0.050000   1.000  1.000

23001700 M    Goat, meat byproducts              0.100000   1.000  1.000

23001710 M    Goat, fat                          0.100000   1.000  1.000

23001720 M    Goat, kidney                       0.100000   1.000  1.000

23001730 M    Goat, liver                        0.200000   1.000  1.000

24001890 M    Horse, meat                        0.050000   1.000  1.000

25002900 M    Pork, meat                         0.050000   1.000  1.000

25002901 M    Pork, meat-babyfood                0.050000   1.000  1.000

25002910 M    Pork, skin                         0.100000   1.000  1.000

25002920 M    Pork, meat byproducts              0.100000   1.000  1.000

25002921 M    Pork, meat byproducts-babyfood     0.100000   1.000  1.000

25002930 M    Pork, fat                          0.100000   1.000  1.000

25002931 M    Pork, fat-babyfood                 0.100000   1.000  1.000

25002940 M    Pork, kidney                       0.100000   1.000  1.000

25002950 M    Pork, liver                        0.200000   1.000  1.000

26003390 M    Sheep, meat                        0.050000   1.000  1.000

26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000

26003400 M    Sheep, meat byproducts             0.100000   1.000  1.000

26003410 M    Sheep, fat                         0.100000   1.000  1.000

26003411 M    Sheep, fat-babyfood                0.100000   1.000  1.000

26003420 M    Sheep, kidney                      0.100000   1.000  1.000

26003430 M    Sheep, liver                       0.200000   1.000  1.000

70001450 P    Egg, whole                         0.100000   1.000  1.000

70001451 P    Egg, whole-babyfood                0.100000   1.000  1.000

70001460 P    Egg, white                         0.100000   1.000  1.000

70001461 P    Egg, white (solids)-babyfood       0.100000   1.000  1.000

70001470 P    Egg, yolk                          0.100000   1.000  1.000

70001471 P    Egg, yolk-babyfood                 0.100000   1.000  1.000

27002220 D    Milk, fat                          0.010000   1.000  1.000

27002221 D    Milk, fat - baby food/infant for   0.010000   1.000  1.000

27012230 D    Milk, nonfat solids                0.010000   1.000  1.000

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000  1.000

27022240 D    Milk, water                        0.010000   1.000  1.000

27022241 D    Milk, water-babyfood/infant form   0.010000   1.000  1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000  1.000

01010520 1A   Beet, sugar                        0.300000   1.000  1.000

01010521 1A   Beet, sugar-babyfood               0.300000   1.000  1.000

01010530 1A   Beet, sugar, molasses              0.300000   0.600  1.000

01010531 1A   Beet, sugar, molasses-babyfood     0.300000   0.600  1.000

01032960 1C   Potato, chips                      0.005000   0.500  1.000

01032970 1C   Potato, dry (granules/ flakes)     0.005000   0.500  1.000

01032971 1C   Potato, dry (granules/ flakes)-b   0.005000   0.500  1.000

01032980 1C   Potato, flour                      0.005000   0.500  1.000

01032981 1C   Potato, flour-babyfood             0.005000   0.500  1.000

01032990 1C   Potato, tuber, w/peel              0.005000   1.000  1.000

01032991 1C   Potato, tuber, w/peel-babyfood     0.005000   1.000  1.000

01033000 1C   Potato, tuber, w/o peel            0.005000   1.000  1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.005000   1.000  1.000

03001640 3    Garlic                             0.200000   1.000  1.000

03001650 3    Garlic, dried                      0.200000   1.000  1.000

03001651 3    Garlic, dried-babyfood             0.200000   1.000  1.000

03001980 3    Leek                               6.000000   1.000  1.000

03002370 3    Onion, dry bulb                    0.200000   1.000  1.000

03002371 3    Onion, dry bulb-babyfood           0.200000   1.000  1.000

03002380 3    Onion, dry bulb, dried             0.200000   9.000  1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.200000   9.000  1.000

03002390 3    Onion, green                       6.000000   1.000  1.000

03003380 3    Shallot                            0.200000   1.000  1.000

05010610 5A   Broccoli                           0.221000   1.000  1.000

05010611 5A   Broccoli-babyfood                  0.221000   1.000  1.000

05010620 5A   Broccoli, Chinese                  0.221000   1.000  1.000

05020630 5B   Broccoli raab                      5.100000   1.000  1.000

05010640 5A   Brussels sprouts                  29.000000   1.000  1.000

05010690 5A   Cabbage                            0.029000   1.000  1.000

05020700 5B   Cabbage, Chinese, bok choy         5.100000   1.000  1.000

05010710 5A   Cabbage, Chinese, napa             0.029000   1.000  1.000

05010720 5A   Cabbage, Chinese, mustard          0.221000   1.000  1.000

05010830 5A   Cauliflower                        0.221000   1.000  1.000

05021170 5B   Collards                           5.100000   1.000  1.000

05021940 5B   Kale                               5.100000   1.000  1.000

05011960 5A   Kohlrabi                           0.029000   1.000  1.000

05022290 5B   Mustard greens                     5.100000   1.000  1.000

05023180 5B   Rape greens                        5.100000   1.000  1.000

05023890 5B   Turnip, greens                     5.100000   1.000  1.000

08001480 8    Eggplant                           0.133000   1.000  1.000

08002340 8    Okra                               0.600000   1.000  1.000

08002700 8    Pepper, bell                       0.133000   1.000  1.000

08002701 8    Pepper, bell-babyfood              0.133000   1.000  1.000

08002710 8    Pepper, bell, dried                0.133000   1.000  1.000

08002711 8    Pepper, bell, dried-babyfood       0.133000   1.000  1.000

08002720 8    Pepper, nonbell                    0.133000   1.000  1.000

08002721 8    Pepper, nonbell-babyfood           0.133000   1.000  1.000

08002730 8    Pepper, nonbell, dried             0.133000   1.000  1.000

08003740 8    Tomatillo                          0.165000   1.000  1.000

08003750 8    Tomato                             0.165000   1.000  1.000

08003751 8    Tomato-babyfood                    0.165000   1.000  1.000

08003760 8    Tomato, paste                      0.165000   1.600  1.000

08003761 8    Tomato, paste-babyfood             0.165000   1.600  1.000

08003770 8    Tomato, puree                      0.165000   0.500  1.000

08003771 8    Tomato, puree-babyfood             0.165000   0.500  1.000

08003780 8    Tomato, dried                      0.165000  14.300  1.000

08003781 8    Tomato, dried-babyfood             0.165000  14.300  1.000

08003790 8    Tomato, juice                      0.165000   1.500  1.000

09020210 9B   Balsam pear                        0.055000   1.000  1.000

09010750 9A   Cantaloupe                         0.137000   1.000  1.000

09010800 9A   Casaba                             0.137000   1.000  1.000

09020880 9B   Chayote, fruit                     0.310000   1.000  1.000

09021020 9B   Chinese waxgourd                   0.055000   1.000  1.000

09021350 9B   Cucumber                           0.055000   1.000  1.000

09011870 9A   Honeydew melon                     0.137000   1.000  1.000

09023080 9B   Pumpkin                            0.031000   1.000  1.000

09023090 9B   Pumpkin, seed                      0.031000   1.000  1.000

09023560 9B   Squash, summer                     0.031000   1.000  1.000

09023561 9B   Squash, summer-babyfood            0.031000   1.000  1.000

09023570 9B   Squash, winter                     0.031000   1.000  1.000

09023571 9B   Squash, winter-babyfood            0.031000   1.000  1.000

09013990 9A   Watermelon                         0.137000   1.000  1.000

09014000 9A   Watermelon, juice                  0.137000   1.000  1.000

10001060 10   Citrus citron                      0.208000   1.000  1.000

10001070 10   Citrus hybrids                     0.208000   1.000  1.000

10001080 10   Citrus, oil                       25.000000   1.000  1.000

10001800 10   Grapefruit                         0.120000   1.000  1.000

10001810 10   Grapefruit, juice                  0.120000   0.100  1.000

10001970 10   Kumquat                            0.208000   1.000  1.000

10001990 10   Lemon                              0.176000   1.000  1.000

10002000 10   Lemon, juice                       0.176000   0.100  1.000

10002001 10   Lemon, juice-babyfood              0.176000   0.100  1.000

10002010 10   Lemon, peel                        0.176000   1.000  1.000

10002060 10   Lime                               0.176000   1.000  1.000

10002070 10   Lime, juice                        0.176000   0.100  1.000

10002071 10   Lime, juice-babyfood               0.176000   0.100  1.000

10002400 10   Orange                             0.208000   1.000  1.000

10002410 10   Orange, juice                      0.208000   0.100  1.000

10002411 10   Orange, juice-babyfood             0.208000   0.100  1.000

10002420 10   Orange, peel                       0.208000   1.000  1.000

10003070 10   Pummelo                            0.120000   1.000  1.000

10003690 10   Tangerine                          0.208000   1.000  1.000

10003700 10   Tangerine, juice                   0.208000   0.100  1.000

11000070 11   Apple, fruit with peel             0.203000   1.000  1.000

11000080 11   Apple, peeled fruit                0.203000   1.000  1.000

11000081 11   Apple, peeled fruit-babyfood       0.203000   1.000  1.000

11000090 11   Apple, dried                       0.203000   8.000  1.000

11000091 11   Apple, dried-babyfood              0.203000   8.000  1.000

11000100 11   Apple, juice                       0.203000   0.040  1.000

11000101 11   Apple, juice-babyfood              0.203000   0.040  1.000

11000110 11   Apple, sauce                       0.203000   1.000  1.000

11000111 11   Apple, sauce-babyfood              0.203000   1.000  1.000

11001290 11   Crabapple                          0.203000   1.000  1.000

11002100 11   Loquat                             0.123000   1.000  1.000

11002660 11   Pear                               0.123000   1.000  1.000

11002661 11   Pear-babyfood                      0.123000   1.000  1.000

11002670 11   Pear, dried                        0.123000   6.250  1.000

11002680 11   Pear, juice                        0.123000   1.000  1.000

11002681 11   Pear, juice-babyfood               0.123000   1.000  1.000

11003100 11   Quince                             0.123000   1.000  1.000

14000030 14   Almond                             0.005000   1.000  1.000

14000031 14   Almond-babyfood                    0.005000   1.000  1.000

14000040 14   Almond, oil                        0.005000   1.000  1.000

14000041 14   Almond, oil-babyfood               0.005000   1.000  1.000

14000590 14   Brazil nut                         0.007000   1.000  1.000

14000680 14   Butternut                          0.007000   1.000  1.000

14000810 14   Cashew                             0.007000   1.000  1.000

14000920 14   Chestnut                           0.005000   1.000  1.000

14001550 14   Filbert                            0.007000   1.000  1.000

14001560 14   Filbert, oil                       0.007000   1.000  1.000

14001850 14   Hickory nut                        0.007000   1.000  1.000

14002130 14   Macadamia nut                      0.007000   1.000  1.000

14002690 14   Pecan                              0.007000   1.000  1.000

14002820 14   Pistachio                          0.005000   1.000  1.000

14003910 14   Walnut                             0.007000   1.000  1.000

15000250 15   Barley, pearled barley             0.100000   1.000  1.000

15000251 15   Barley, pearled barley-babyfood    0.100000   1.000  1.000

15000260 15   Barley, flour                      0.100000   1.000  1.000

15000261 15   Barley, flour-babyfood             0.100000   1.000  1.000

15000270 15   Barley, bran                       0.100000   1.000  1.000

15001270 15   Corn, sweet                        0.010000   1.000  1.000

15001271 15   Corn, sweet-babyfood               0.010000   1.000  1.000

15003280 15   Rye, grain                         0.100000   1.000  1.000

15003290 15   Rye, flour                         0.100000   1.000  1.000

15004010 15   Wheat, grain                       0.100000   1.000  1.000

15004011 15   Wheat, grain-babyfood              0.100000   1.000  1.000

15004020 15   Wheat, flour                       0.100000   1.000  1.000

15004021 15   Wheat, flour-babyfood              0.100000   1.000  1.000

15004030 15   Wheat, germ                        0.100000   1.000  1.000

15004040 15   Wheat, bran                        0.100000   1.000  1.000

Attachment 4:  DEEM-FCID( Chronic Exposure Estimates

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for DIFENOCONAZOLE                   (1994-98 data)

Residue file name: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 DifenocozoleNew Uses of Wax Apple and Mango\difenoconazole_chronic-01-10AverageFT.R98

                                                     Adjustment factor #2 used.

Analysis Date 01-12-2010/14:26:21     Residue file dated: 01-12-2010/14:24:16/8

Reference dose (RfD, Chronic) = .01 mg/kg bw/day

======================================================================== =======

                    Total exposure by population subgroup

------------------------------------------------------------------------ -------

                                                    Total Exposure

                                         -----------------------------------

          Population                         mg/kg             Percent of

           Subgroup                       body wt/day             Rfd

--------------------------------------   -------------       ---------------

U.S. Population (total)                     0.001709                17.1%

U.S. Population (spring season)             0.001689                16.9%

U.S. Population (summer season)             0.001761                17.6%

U.S. Population (autumn season)             0.001678                16.8%

U.S. Population (winter season)             0.001710                17.1%

Northeast region                            0.001653                16.5%

Midwest region                              0.001671                16.7%

Southern region                             0.001610                16.1%

Western region                              0.001958                19.6%

Hispanics                                   0.001635                16.3%

Non-hispanic whites                         0.001626                16.3%

Non-hispanic blacks                         0.002000                20.0%

Non-hisp/non-white/non-black                0.002426                24.3%

All infants (< 1 year)                      0.002445                24.5%

Nursing infants                             0.001287                12.9%

Non-nursing infants                         0.002885                28.9%

Children 1-6  yrs                           0.003762                37.6%

Children 7-12 yrs                           0.001941                19.4%

Females 13-19 (not preg or nursing)         0.001233                12.3%

Females 20+ (not preg or nursing)           0.001490                14.9%

Females 13-50 yrs                           0.001475                14.7%

Females 13+ (preg/not nursing)              0.001295                13.0%

Females 13+ (nursing)                       0.001522                15.2%

Males 13-19 yrs                             0.001506                15.1%

Males 20+ yrs                               0.001385                13.9%

Seniors 55+                                 0.001574                15.7%

Children 1-2 yrs                            0.004484                44.8%

Children 3-5 yrs                            0.003624                36.2%

Children 6-12 yrs                           0.002061                20.6%

Youth 13-19 yrs                             0.001372                13.7%

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Adults 20-49 yrs                            0.001376                13.8%

Adults 50+ yrs                              0.001548                15.5%

Females 13-49 yrs                           0.001402                14.0%

------------------------------------------------------------------------ -------

Difenoconazole	Dietary Exposure Assessment	DP#: 371613

PC Code: 128847

  PAGE  1  of   NUMPAGES  19


[Federal Register Volume 86, Number 178 (Friday, September 17, 2021)]
[Notices]
[Pages 51883-51884]
[FR Doc No: 2021-20135]

-----------------------------------------------------------------------

DEPARTMENT OF ENERGY

Federal Energy Regulatory Commission

[Project No. 6440-010]

Lakeport Hydroelectric One, LLC; Notice of Application Tendered
for Filing With the Commission and Soliciting Additional Study Requests
and Establishing Procedural Schedule for Relicensing and a Deadline for
Submission of Final Amendments

    Take notice that the following hydroelectric application has been
filed with the Commission and is available for public inspection.
    a. Type of Application: Subsequent Minor License.
    b. Project No.: 6440-010.
    c. Date filed: August 30, 2021.
    d. Applicant: Lakeport Hydroelectric One, LLC (Lakeport).
    e. Name of Project: Lakeport Hydroelectric Project (project).
    f. Location: On the Winnipesaukee River in Belknap County, New
Hampshire. The project does not occupy any federal land.
    g. Filed Pursuant to: Federal Power Act 16 U.S.C. 791(a)-825(r).
    h. Applicant Contact: Ms. Jody Smet, Lakeport Hydroelectric One,
LLC c/o Eagle Creek Renewable Energy, LLC, 7315 Wisconsin Avenue, Suite
1100W, Bethesda, MD 20814; Phone at<PHONE_NUMBER>, or email at
<EMAIL_ADDRESS>    i. FERC Contact: Erin Kimsey at<PHONE_NUMBER>, or
<EMAIL_ADDRESS>    j. Cooperating agencies: Federal, state, local, and tribal agencies
with jurisdiction and/or special expertise with respect to
environmental issues that wish to cooperate in the preparation of the
environmental document should follow the instructions for filing such
requests described in item l below. Cooperating agencies should note
the Commission's policy that agencies that cooperate in the preparation
of the environmental document cannot also intervene. See 94 FERC ]
61,076 (2001).
    k. Pursuant to section 4.32(b)(7) of 18 CFR of the Commission's
regulations, if any resource agency, Indian Tribe, or person believes
that an additional scientific study should be conducted in order to
form an adequate factual basis for a complete analysis of the
application on its merit, the resource agency, Indian Tribe, or person
must file a request for a study with the Commission not later than 60
days from the date of filing of the application, and serve a copy of
the request on the applicant.
    l. Deadline for filing additional study requests and requests for
cooperating agency status: October 29, 2021.
    The Commission strongly encourages electronic filing. Please file
additional study requests and requests for cooperating agency status
using the Commission's eFiling system at https://ferconline.ferc.gov/FERCOnline.aspx. For assistance, please contact FERC Online Support at
<EMAIL_ADDRESS>(866) 208-3676 (toll free), or (202) 502-
8659 (TTY). In lieu of electronic filing, you may submit a paper copy.
Submissions sent via the U.S. Postal Service must be addressed to:
Kimberly D. Bose, Secretary, Federal Energy Regulatory Commission, 888
First Street NE, Room 1A, Washington, DC 20426. Submissions sent via
any other carrier must be addressed to: Kimberly D. Bose, Secretary,
Federal Energy Regulatory Commission, 12225 Wilkins Avenue, Rockville,
MD 20852. All filings must clearly identify the project name and docket
number on the first page: Lakeport Hydroelectric Project (P-6440-010).
    m. The application is not ready for environmental analysis at this
time.
    n. Project Description: The existing Lakeport Project consists of:
(1) A 220-foot-long, 10-foot-high concrete gravity dam that includes
three 10-foot-high, 18-foot-wide gates, a spillway, and a stoplog gate;
(2) an impoundment with a surface area of approximately 70 square miles
at an elevation of 504 feet NGVD 29; (3) a 40-foot-wide, 12-foot-long
concrete and granite intake structure that is equipped with three
headgates and a trashrack with 2-inch clear bar spacing with a 0.75-
inch overlay; (4) a concrete and lumber powerhouse containing three
200-kilowatt (kW) vertical submersible Flygt turbine-generator units
located on concrete pilings outside for a total installed capacity of
600 kW; (5) a 200-foot-long, 50-foot-wide tailrace that discharges into
the Winnipesaukee River; (6) three 0.48-kilovolt (kV) generator leads,
three 0.48/12.4-kV step-up transformers, and a 250-foot-long, 12.4 kV
transmission line that connect the project to the local utility
distribution system; and (7) appurtenant facilities.
    The project is operated as a run of-river facility. The average
annual generation of the project is approximately 2,250 megawatt-hours.
    o. In addition to publishing the full text of this notice in the
Federal Register, the Commission provides all interested persons an
opportunity to view and/or print the contents of this notice, as well
as other documents in the proceeding (e.g., license application) via
the internet through the Commission's Home Page (http://www.ferc.gov)
using the ``eLibrary'' link. Enter the docket number excluding the last
three digits in the docket number field to access the document (P-
6440). For assistance, contact FERC at<EMAIL_ADDRESS>or
call toll-free,<PHONE_NUMBER> or<PHONE_NUMBER> (TTY).
    You may also register online at https://ferconline.ferc.gov/FERCOnline.aspx to be notified via email of new filings and issuances
related to this or other pending projects. For assistance, contact FERC
Online Support.
    p. Procedural schedule: The application will be processed according
to the following preliminary schedule. Revisions to the schedule will
be made as appropriate.

Issue Deficiency Letter (if necessary)--October 2021
Request Additional Information--October 2021
Issue Scoping Document 1 for comments--January 2022
Request Additional Information (if necessary)--February 2022
Issue Acceptance Letter--February 2022
Issue Scoping Document 2--March 2022
Issue Notice of Ready for Environmental Analysis--March 2022

    q. Final amendments to the application must be filed with the
Commission no later than 30 days from

the issuance date of the notice of ready for environmental analysis.

Kimberly D. Bose,
Secretary.
[FR Doc. 2021-20135 Filed 9-16-21; 8:45 am]
BILLING CODE 6717-01-P


[Federal Register Volume 83, Number 107 (Monday, June 4, 2018)]
[Notices]
[Pages 25733-25734]
[FR Doc No: 2018-11886]

-----------------------------------------------------------------------

DEPARTMENT OF TRANSPORTATION

Federal Railroad Administration

[Docket Number FRA-2018-0033]

Petition for Waiver of Compliance

    Under part 211 of Title 49 of the Code of Federal Regulations
(CFR), this provides the public notice that on March 30, 2018, Michigan
State Trust for Railway Preservation, Inc. (MSTP) petitioned the
Federal Railroad Administration (FRA) for a waiver of compliance from
certain provisions of the Federal railroad safety regulations contained
at 49 CFR 240.201(d). FRA assigned the petition Docket Number FRA-2018-
0033.
    MSTP seeks a waiver of compliance from 49 CFR 240.201(d) which
states, ``After December 31, 1991, no railroad shall permit or require
any person to operate a locomotive in any class of locomotive or train
service unless that person has been certified as a qualified locomotive
engineer and issued a certificate that complies with Sec.  240.223.''
MSTP desires to conduct a ``Hands on the Throttle Program,'' which
would allow ``non-certified'' individuals to operate a locomotive as a
``Student Locomotive Engineer.''
    MSTP is a non-profit educational corporation which owns and
operates steam locomotives. The organization is located at the steam
locomotive repair facility in Owosso, Michigan, and connected to the
tracks of the Great Lakes Central Railway (GLC). The MSTP does not own
or control any trackage, except for the track leads going to the repair
shop building and museum.
    As proposed, MSTP will verify that each participant possesses a
valid state issued motor vehicle license, and will have a certified
locomotive engineer in the cab at all times. The operations will be
conducted on GLC designated tracks during daylight hours with only one
locomotive movement at a time, operate at restricted speed,
communication will be maintained through the GCL dispatcher, and be
afforded blue flag and derail protection. The locomotive will be
inspected daily, receive a new brake test per participant, and public
highway grade crossings will not be involved. MSTP believes that this
waiver will enable it to generate needed interest and revenue to teach
steam technology to future generations. MSTP also believes these
operations will not pose any safety concerns to the public at large.
    A copy of the petition, as well as any written communications
concerning the petition, is available for review online at
www.regulations.gov and in person at the U.S. Department of
Transportation's (DOT) Docket Operations Facility, 1200 New Jersey Ave.
SE, W12-140, Washington, DC 20590. The Docket Operations Facility is
open from 9 a.m. to 5 p.m., Monday through Friday, except Federal
Holidays.
    Interested parties are invited to participate in these proceedings
by submitting written views, data, or comments. FRA does not anticipate
scheduling a public hearing in connection with these proceedings since
the facts do not appear to warrant a hearing. If any interested parties
desire an opportunity for oral comment and a public hearing, they
should notify FRA, in writing, before the end of the comment period and
specify the basis for their request.
    All communications concerning these proceedings should identify the
appropriate docket number and may be submitted by any of the following
methods:
     Website: http://www.regulations.gov. Follow the online
instructions for submitting comments.
     Fax:<PHONE_NUMBER>.
     Mail: Docket Operations Facility, U.S. Department of
Transportation, 1200 New Jersey Avenue SE, W12-140, Washington, DC
20590.
     Hand Delivery: 1200 New Jersey Avenue SE, Room W12-140,
Washington, DC 20590, between 9 a.m. and 5 p.m., Monday through Friday,
except Federal Holidays.
    Communications received by July 19, 2018 will be considered by FRA
before final action is taken. Comments received after that date will be
considered if practicable. Anyone can search the electronic form of any
written communications and comments received into any of our dockets by
the name of the individual submitting the comment (or signing the
document, if submitted on behalf of an association, business, labor
union, etc.). Under 5 U.S.C. 553(c), DOT solicits comments from the
public to better inform its processes. DOT posts these comments,
without edit, including any personal information the commenter
provides, to www.regulations.gov, as described in

the system of records notice (DOT/ALL-14 FDMS), which can be reviewed
at https://www.transportation.gov/privacy. See also https://www.regulations.gov/privacyNotice for the privacy notice of
regulations.gov.

Robert C. Lauby,
Associate Administrator for Railroad Safety, Chief Safety Officer.
[FR Doc. 2018-11886 Filed 6-1-18; 8:45 am]
 BILLING CODE 4910-06-P


[Federal Register Volume 76, Number 86 (Wednesday, May 4, 2011)]
[Proposed Rules]
[Pages 25273-25274]
[FR Doc No: 2011-10868]

=======================================================================
-----------------------------------------------------------------------

SECURITIES AND EXCHANGE COMMISSION

17 CFR Parts 229 and 240

[Release Nos. 33-9203; 34-64366; File No. S7-13-11]
RIN 3235-AK95

Listing Standards for Compensation Committees

AGENCY: Securities and Exchange Commission.

ACTION: Proposed rule; extension of comment period.

-----------------------------------------------------------------------

SUMMARY: The Securities and Exchange Commission is extending the
comment period for a release proposing a new rule and rule amendments
to implement the provisions of Section 952 of the Dodd-Frank Wall
Street Reform and Consumer Protection Act of 2010, which added Section
10C to the Securities Exchange Act of 1934 (the ``Exchange Act'').
[Release No. 33-9199; 76 FR 18966 (April 6, 2011)]. The original
comment period for Release 33-9199 is scheduled to end on April 29,
2011. The Commission is extending the time period in which to provide
the Commission with comments on that release to May 19, 2011. This
action will allow interested persons additional time to analyze the
issues and prepare their comments.

DATES: Comments should be received on or before May 19, 2011.

ADDRESSES: Comments may be submitted by any of the following methods:

Electronic Comments

     Use the Commission's Internet comment form (http://www.sec.gov/rules/proposed.shtml);
     Send an e-mail to<EMAIL_ADDRESS>or
     Use the Federal Rulemaking ePortal (http://www.regulations.gov). Follow the instructions for submitting comments.

Paper Comments

     Send paper comments in triplicate to Elizabeth M. Murphy,
Secretary, U.S. Securities and Exchange Commission, 100 F Street, NE.,
Washington, DC 20549-1090.

All submissions should refer to File Number S7-13-11. This file number
should be included on the subject line if e-mail is used. To help us
process and review your comments more efficiently, please use only one
method. The Commission will post all comments on the Commission's
Internet Web site (http://www.sec.gov/rules/proposed.shtml). Comments
are also available for Web site viewing and printing in the
Commission's Public Reference Room, 100 F Street, NE., Washington, DC
20549, on official business days between the hours of

10 a.m. and 3 p.m. All comments received will be posted without change;
we do not edit personal identifying information from submissions. You
should submit only information that you wish to make available
publicly.

FOR FURTHER INFORMATION CONTACT: N. Sean Harrison, Special Counsel, at
(202) 551-3430, in the Office of Rulemaking, Division of Corporation
Finance, U.S. Securities and Exchange Commission, 100 F Street, NE.,
Washington, DC 20549-3628.

SUPPLEMENTARY INFORMATION: The Commission has requested comment on a
release proposing a new rule and rule amendments to implement the
provisions of Section 952 of the Dodd-Frank Wall Street Reform and
Consumer Protection Act of 2010, which added Section 10C to the
Exchange Act. Section 10C requires the Commission to adopt rules
directing the national securities exchanges (the ``exchanges'') and
national securities associations to prohibit the listing of any equity
security of an issuer that is not in compliance with Section 10C's
compensation committee and compensation adviser requirements. In
accordance with the statute, the proposed rule would direct the
exchanges to establish listing standards that, among other things,
require each member of a listed issuer's compensation committee to be a
member of the board of directors and to be ``independent,'' as defined
in the listing standards of the exchanges adopted in accordance with
the proposed rule. In addition, Section 10C(c)(2) of the Exchange Act
requires the Commission to adopt new disclosure rules concerning the
use of compensation consultants and conflicts of interest. The
Commission approved the proposal at an open meeting on March 30, 2011,
and the release was posted on the Commission's Web site on that date.
The release was published in the Federal Register on April 6, 2011.
    The Commission originally requested that comments on the release be
received by April 29, 2011. A commentator has asked that the Commission
extend the period of time for public comment on the proposing
release.\1\ After considering the request and the issues presented by
the release, the Commission believes that providing the public
additional time to consider the matters addressed by the release and to
submit responses to the release would benefit the Commission in its
consideration of final rules. Therefore, the Commission is extending
the comment period for Release No. 33-9199, ``Listing Standards for
Compensation Committees,'' to May 19, 2011.
---------------------------------------------------------------------------

    \1\ See letter from Center for Capital Markets Competitiveness
of the U.S. Chamber of Commerce (Apr. 15, 2011). Comments are
available on the Commission's Internet Web site at http://www.sec.gov/comments/s7-13-11/s71311.shtml.

---------------------------------------------------------------------------
    Dated: April 29, 2011.

    By the Commission.
Cathy H. Ahn,
Deputy Secretary.
[FR Doc. 2011-10868 Filed 5-3-11; 8:45 am]
BILLING CODE 8011-01-P


[Federal Register Volume 87, Number 85 (Tuesday, May 3, 2022)]
[Proposed Rules]
[Pages 26146-26147]
[FR Doc No: 2022-09497]

=======================================================================
-----------------------------------------------------------------------

ENVIRONMENTAL PROTECTION AGENCY

40 CFR Parts 2, 59, 60, 80, 85, 86, 87, 600, 1027, 1030, 1033,
1036, 1037, 1039, 1042, 1043, 1045, 1048, 1051, 1054, 1060, 1065,
1066, 1068, and 1090

[EPA-HQ-OAR-2019-0055; FRL-9813-01-OAR]

Control of Air Pollution From New Motor Vehicles: Heavy-Duty
Engine and Vehicle Standards; Extension of Comment Period

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice; extension of public comment period.

-----------------------------------------------------------------------

SUMMARY: On March 28, 2022, the Environmental Protection Agency (EPA)
published a proposed rule titled ``Control of Air Pollution from New
Motor Vehicles: Heavy-Duty Engine and Vehicle Standards''. EPA is
extending the comment period for this proposed rule.

DATES: The comment period for the proposed rule published on March 28,
2022, at 87 FR 17414, is extended. Comments must be received on or
before May 16, 2022.

ADDRESSES: You may send your comments, identified by Docket ID No. EPA-
HQ-OAR-2019-0055, by any of the following methods:

     Federal eRulemaking Portal: http://www.regulations.gov
(our preferred method) Follow the online instructions for submitting
comments.
     Mail: U.S. Environmental Protection Agency, EPA Docket
Center, Office of Air and Radiation Docket, Mail Code 28221T, 1200
Pennsylvania Avenue NW, Washington, DC 20460.
     Hand Delivery/Courier: EPA Docket Center, WJC West
Building, Room 3334, 1301 Constitution Avenue NW, Washington, DC 20004.
The Docket Center's hours of operations are 8:30 a.m.-4:30 p.m.,
Monday-Friday (except Federal Holidays).
    Instructions: All submissions received must include the Docket ID
No. for this rulemaking. Comments received may be posted without change
to https://www.regulations.gov/, including any personal information
provided. Submit your comments, identified by Docket ID No. EPA-HQ-OAR-
2019-0055, at https://www.regulations.gov (our preferred method), or
the other methods identified in the ADDRESSES section. Once submitted,
comments cannot be edited or removed from the docket. The EPA may
publish any comment received to its public docket. Do not submit
electronically any information you consider to be Confidential Business
Information (CBI) or other information whose disclosure is restricted
by statute. Multimedia submissions (audio, video, etc.) must be
accompanied by a written comment. The written comment is considered the
official comment and should include discussion of all points you wish
to make. The EPA will generally not consider comments or comment
contents located outside of the primary submission (i.e., on the web,
cloud, or other file sharing system). For additional submission
methods, the full EPA public comment policy, information about CBI or
multimedia submissions, and general guidance on making effective
comments, please visit https://www.epa.gov/dockets/commenting-epa-dockets.
    Due to public health concerns related to COVID-19, the EPA Docket
Center and Reading Room are open to the public by appointment only. Our
Docket Center staff also continues to provide remote customer service
via email, phone, and webform. Hand deliveries or couriers will be
received by scheduled appointment only. For further information and
updates on EPA Docket Center services, please visit us online at
https://www.epa.gov/dockets.
    The EPA continues to carefully and continuously monitor information
from the Centers for Disease Control and Prevention (CDC), local area
health departments, and our Federal partners so that we can respond
rapidly as conditions change regarding COVID-19.

FOR FURTHER INFORMATION CONTACT: Brian Nelson, Assessment and Standards
Division, Office of Transportation and Air Quality, Environmental
Protection Agency, 2000 Traverwood Drive, Ann Arbor, MI 48105;
telephone number:<PHONE_NUMBER>; email address: [email protected].

SUPPLEMENTARY INFORMATION: On March 28, 2022, EPA published a proposed
rule titled ``Control of Air Pollution from New Motor Vehicles: Heavy-
Duty Engine and Vehicle Standards'' (87 FR 17414). The public comment
for this proposed rule was scheduled to end on May 13, 2022. The Clean
Air Act requires that the record of proceedings allowing oral
presentation of data, views, and arguments on a proposed rule be kept
open for 30 days after completion of the proceeding to provide an
opportunity for submission of rebuttal and supplementary information.
42 U.S.C. 7607(d)(5). Because EPA held a third day of public hearing
for this proposed rule, the final ``proceeding allowing oral
presentation of data, views, and arguments,'' was held on April 14,
2022. For this reason, the public comment period for this proposed rule
is extended and will now end on May 16, 2022.

Benjamin Hengst,
Deputy Director, Office of Transportation and Air Quality.
[FR Doc. 2022-09497 Filed 5-2-22; 8:45 am]
BILLING CODE 6560-50-P