[Federal Register: October 10, 2006 (Volume 71, Number 195)]
[Notices]
[Page 59561-59562]
[DOCID:fr10oc06-94]

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SECURITIES AND EXCHANGE COMMISSION

[Release No. 34-54553; File No. SR-Amex-2006-91]

Self-Regulatory Organizations; American Stock Exchange LLC;
Notice of Filing and Immediate Effectiveness of a Proposed Rule Change
Relating to the Extension of the Pilot Period Applicable to the Listing
and Trading of Options on the iShares MSCI Emerging Markets Index

 September 29, 2006.
    Pursuant to Section 19(b)(1) of the Securities Exchange Act of 1934
(``Act''),\1\ and Rule 19b-4 thereunder,\2\ notice is hereby given that
on September 28, 2006, the American Stock Exchange LLC (``Amex'' or
``Exchange'') filed with the Securities and Exchange Commission
(``Commission'') the proposed rule change as described in Items I and
II below, which Items have been prepared by the Exchange. The Amex has
filed the proposed rule change, pursuant to Section 19(b)(3)(A)(iii) of
the Act \3\ and Rule 19b-4(f)(6) thereunder,\4\ which renders the
proposal effective upon filing with the Commission.\5\ The Commission
is publishing this notice to solicit comments on the proposed rule
change from interested persons.
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    \1\ 15 U.S.C. 78s(b)(1).
    \2\ 17 CFR 240.19b-4.
    \3\ 15 U.S.C. 78s(b)(3)(A)(iii).
    \4\ 17 CFR 240.19b-4(f)(6).
    \5\ The Exchange requested the Commission to waive the five-day
pre-filing notice requirement and the 30-day operative delay, as
specified in Rule 19b(f)(6)(iii). 17 CFR 240.19b-4(f)(6)(iii).
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I. Self-Regulatory Organization's Statement of the Terms of Substance
of the Proposed Rule Change

    The Exchange proposes to extend the pilot period applicable to the
listing and trading of options on the iShares MSCI Emerging Markets
Index Fund (``Fund Options''). The Amex is not proposing any changes to
the rule text. The text of the proposed rule change is available on the
Amex's Web site at http://www.amex.com, the Office of the Secretary,

Amex and at the Commission's Public Reference Room.

II. Self-Regulatory Organization's Statement of the Purpose of, and
Statutory Basis for, the Proposed Rule Change

    In its filing with the Commission, Amex included statements
concerning the purpose of, and basis for, the proposed rule change and
discussed any comments it received on the proposed rule change. The
text of these statements may be examined at the places specified in
Item IV below. The Amex has prepared summaries, set forth in Sections
A, B, and C below, of the most significant aspects of such statements.

A. Self-Regulatory Organization's Statement of the Purpose of, and
Statutory Basis for, the Proposed Rule Change

1. Purpose
    On May 17, 2006, the Commission approved the Amex's proposal to
list and trade the Fund Options.\6\ On June 30, 2006 the Commission
approved a 90-day extension to the Pilot that is due to expire October
1, 2006.\7\ The Fund Options will continue to meet substantially all of
the listing and maintenance standards in Commentary .06 to Amex Rule
915 and Commentary .07 to Amex Rule 916. For the requirements that are
not satisfied, the Exchange continues to represent that sufficient
mechanisms exist that would provide the Exchange with adequate
surveillance and regulatory information with respect to the Fund
Options. Continuation of the Pilot would permit the Exchange to
continue to work with the Bolsa Mexicana de Valores (``Bolsa'') to
develop a surveillance sharing agreement.
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    \6\ See Securities Exchange Act Release No. 53824 (May 17,
2006), 71 FR 30003 (May 24, 2006) (SR-Amex-2006-43).
    \7\ See Securities Exchange Act Release No. 54081 (June 30,
2006), 71 FR 38911 (July 10, 2006) (SR-Amex-2006-60).
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    Accordingly, the Exchange proposes to extend the Pilot for an
additional ninety days, until December 30, 2006.\8\
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    \8\ Given that December 30, 2006 is a Saturday, the Commission
notes that the Pilot will in effect be extended until January 2,
2007, the first business day after December 30, 2006.
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2. Statutory Basis
    The Amex believes the proposed rule change is consistent with
Section 6(b) of the Act \9\ in general, and furthers the objectives of
Section 6(b)(5) of the Act,\10\ in particular, in that it is designed
to prevent fraudulent and manipulative acts and practices, to promote
just and equitable principles of trade, to foster cooperation and
coordination with persons engaged in regulating, clearing, settling,
processing information with respect to, and facilitating transactions
in securities, to remove impediments to and perfect the mechanism of a
free and open market and a national market system, and, in general, to
protect investors and the public interest; and is not designed to
permit unfair discrimination between customers,

issuers, brokers, or dealers, or to regulate by virtue of any authority
conferred by the Act matters not related to the purpose of the Act or
the administration of the Amex.
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    \9\ 15 U.S.C. 78f(b).
    \10\ 15 U.S.C. 78f(b)(5).
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B. Self-Regulatory Organization's Statement on Burden on Competition

    Amex does not believe that the proposed rule change will impose any
burden on competition that is not necessary or appropriate in
furtherance of the purposes of the Act.

C. Self-Regulatory Organization's Statement on Comments on the Proposed
Rule Change Received from Members, Participants or Others

    No written comments were solicited or received with respect to the
proposed rule change.

III. Date of Effectiveness of the Proposed Rule Change and Timing for
Commission Action

    The foregoing rule change has become effective pursuant to Section
19(b)(3)(A) of the Act \11\ and Rule 19b-4(f)(6) \12\ thereunder
because the proposed rule change: (i) Does not significantly affect the
protection of investors or the public interest; (ii) does not impose
any significant burden on competition; and (iii) does not become
operative for 30 days from the date of the filing, or such shorter time
as the Commission may designate if consistent with the protection of
investors and the public interest pursuant to Section 19(b)(3)(A)(iii)
of the Act \13\ and Rule 19b-4(f)(6) thereunder.\14\
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    \11\ 15 U.S.C. 78s(b)(3)(A).
    \12\ 17 CFR 240.19b-4(f)(6).
    \13\ 15 U.S.C. 78s(b)(3)(A)(iii).
    \14\ 17 CFR 240.19b-4(f)(6).
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    Amex has requested that the Commission waive both the five-day pre-
filing requirement and the 30-day delayed operative delay.\15\ The
Commission is exercising its authority to waive the five-day pre-filing
notice requirement and believes that the waiver of the 30-day operative
delay is consistent with the protection of investors and the public
interest. Waiver of the five-day pre-filing and 30-day operative
periods will extend the Pilot, which would otherwise expire on October
1, 2006, and allow the Amex to continue in its efforts to obtain a
surveillance agreement with Bolsa. The Commission notes that another
self-regulatory organization recently adopted a substantially similar
rule change that was effective upon filing.\16\ Accordingly, the
Commission designates the proposal to be effective and operative upon
filing with the Commission.\17\
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    \15\ 17 CFR 240.19b-4(f)(6)(iii).
    \16\ See Securities Exchange Act Release No. 54347 (August 22,
2006), 71 FR 51242 (August 29, 2006) (SR-CBOE-2006-72).
    \17\ For purposes only of waiving the 30-day operative delay,
the Commission has considered the proposed rule's impact on
efficiency, competition, and capital formation. 15 U.S.C. 78c(f).
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    At any time within sixty (60) days of the filing of the proposed
rule change, the Commission may summarily abrogate such rule change if
it appears to the Commission that such action is necessary or
appropriate in the public interest, for the protection of investors or
otherwise in furtherance of the purposes of the Act.\18\
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    \18\ See Section 19(b)(3)(C) of the Act, 15 U.S.C. 78s(b)(3)(C).
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IV. Solicitation of Comments

    Interested persons are invited to submit written data, views, and
arguments concerning the foregoing, including whether the proposed rule
change is consistent with the Act. Comments may be submitted by any of
the following methods:

Electronic Comments

     Use the Commission's Internet comment form (http://www.sec.gov/rules/sro.shtml.
); or     Send an e-mail to<EMAIL_ADDRESS>Please include

File Number SR-Amex-2006-91 on the subject line.

Paper Comments

     Send paper comments in triplicate to Nancy M. Morris,
Secretary, Securities and Exchange Commission, 100 F Street, NE.,
Washington, DC 20549-1090.

All submissions should refer to File Number SR-Amex-2006-91. This file
number should be included on the subject line if e-mail is used. To
help the Commission process and review your comments more efficiently,
please use only one method. The Commission will post all comments on
the Commission's Internet Web site (http://www.sec.gov/rules/sro.shtml
). Copies of the submission, all subsequent amendments, all

written statements with respect to the proposed rule change that are
filed with the Commission, and all written communications relating to
the proposed rule change between the Commission and any person, other
than those that may be withheld from the public in accordance with the
provisions of 5 U.S.C. 552, will be available for inspection and
copying in the Commission's Public Reference Section, 100 F Street,
NE., Washington, DC 20549. Copies of such filing also will be available
for inspection and copying at the principal office of the Amex. All
comments received will be posted without change; the Commission does
not edit personal identifying information from submissions. You should
submit only information that you wish to make available publicly. All
submissions should refer to File Number SR-Amex-2006-91 and should be
submitted on or before October 31, 2006.

    For the Commission, by the Division of Market Regulation,
pursuant to delegated authority.\19\
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    \19\ 17 CFR 200.30-3(a)(12).
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Nancy M. Morris,
Secretary.
 [FR Doc. E6-16630 Filed 10-6-06; 8:45 am]

BILLING CODE 8010-01-P


1 January 31, 2003 MEMORANDUM SUBJECT: Atrazine: Addendum to Revised Human Health Risk Assessment for the Reregistration Eligibility Decision ( RED) dated April 16, 2002. PC Code: 080803. DP Barcode: D287740 FROM: Catherine Eiden, Branch Senior Scientist Reregistration Branch 3 Health Effects Division THROUGH: Donna Davis, Branch Chief Reregistration Branch 3 Health Effects Division TO: Kimberly Lowe, Chemical Review Manager Special Review and Reregistration Division Please find attached an addendum to HED's April 16, 2002: Revised Human Health Risk Assessment for the Reregistration Eligibility Decision ( RED). This addendum includes an assessment of any new information and data submitted to the Agency during the 60 day public comment period for the revised human health risk assessment. Any changes in the outcome, updates, or revisions to the revised human health risk assessment are reflected in this addendum. The revised human health risk assessment ( 4/ 16/ 02) and this addendum should be considered together. 2 Background:

During the course of the 60 day public comment period on the revised atrazine human health risk assessment, Syngenta provided additional data, information or studies on atrazine for HED's consideration and review. This additional information has affected some aspects of HED's risk assessment for atrazine. Any changes to the risk assessment based on the additional information are reflected in this addendum. The following issues and/ or data are addressed in this addendum:

° HED's conclusions regarding the need for tolerances for hydroxy atrazine compounds.

° Syngenta's submitted rotational crop study data for garden pea, lima bean, and potatoes.

HED's conclusions and recommendations regarding rotational crop restrictions based on the results of this study.

° HED's reassessment of the DWLOC value to be used in the risk assessment for intermediate term exposures.

° The results of an analysis of Syngenta's submitted probabilistic assessments not previously submitted for an 11 additional community water systems ( CWS) and additional monitoring data on atrazine in finished drinking water for 10 additional states.

° HED's reassessed risk estimates for adults' and toddlers' aggregate short term exposures ( 30 days or less) to atrazine from food, drinking water, and residential uses based on the liquid and granular turf formulations.

° Any revisions or corrections to the occupational/ residential exposure assessment.

Residue Chemistry Tolerance Expression:

Section 9.0  Tolerance Reassessment Recommendations This section should read as follows:

The HED Metabolism Assessment Review Committee ( MARC) met on January 29, 2003 to reconsider the need for and value added in requiring a separate tolerance expression for hydroxy atrazine compounds. The MARC concluded the tolerance expression should include the parent 3 compound atrazine and the chlorinated metabolites.

Tolerances established under 40 CFR § 180.220( a)( 1) are defined for residues of atrazine per se. Tolerances established under 40 CFR § 180.220( a)( 2) are defined for atrazine and its metabolites 2 amino 4 chloro 6 ethylamino s triazine ( G 28279), 2 amino 4 chloro 6 isopropylamino striazine ( G 30033), and 2 chloro 4,6 diamino s triazine ( G 28273).

In accordance with the Metabolism Assessment Review Committee ( MARC) decisions dated 11/ 15/ 00 and 01/ 31/ 03, the tolerance expression in 40 CFR § 180.220( a)( 1) should be changed to reflect the combined residues of atrazine and its chlorinated metabolites: 2 amino 4 chloro 6 ethylamino s triazine ( G 28279), 2 amino 4 chloro 6 isopropylamino s triazine ( G 30033), and 2 chloro 4,6 diamino s triazine ( G 28273) which serve as markers for enforcement purposes of the total residues of atrazine, that is, parent, chlorinated metabolites, and hydroxy metabolites ( 2 hydroxy 4 ethylamino 6 isopropylamino s triazine ( G 34048), 2 amino 4 hydroxy 6 isopropylamino s triazine ( GS 17794), 2 amino 4 hydroxy 6 ethylamino s triazine ( GS 17792), and 2,4 diamino 6 hydroxy s triazine ( GS 17791). All tolerances based on atrazine and its chlorinated metabolites should be placed together under 40 CFR § 180.220 ( a)( 1).

In accordance with MARC memo dated 01/ 31/ 03, the previous requirement for a separate tolerance expression and tolerances for the hydroxy metabolites of atrazine has been rescinded. The MARC concluded that because a validated tolerance enforcement method is available for the parent and chloroinated metabolites, the parent and chlorinated metabolites are detectable by multi residue methods ( 860.1360), and the data collection method for the hydroxy metabolites has not been validated for tolerance enforcement and the hydroxy metabolites have not been tested through the multi residue protocols, a separate tolerance expression for the hydroxy compounds would be ineffective and redundant. In addition, residue data are available from field trials and metabolism studies for dietary risk assessment for the hydroxy compounds, and MARC and HED have determined that finite residues of the hydroxy compounds are not anticipated in animal commodities and classified these commodities under Category 180.6 ( a) 3. However the MARC recommends that the hydroxy metabolites be tested through the multiresidue methods, OPPTS Guideline § 860.1360.

Detectable residues of parent, chlorinated metabolites, and hydroxymetabolites have been found on forages and other feed items. Residues of the parent and chloro metabolites are less than the method detection limit and generally non detectable in/ on corn grain. With one exception, residues of the hydroxy metabolites in/ on corn grain in all of the magnitude of residue and metabolism studies submitted have been less than the limit of quantitation of the data collection method. The only residue exceeding the limit of quantiation was close to the LOQ at an 4 exaggerated application rate. In addition, although the metabolism data suggest that levels of the hydroxy metabolites may exceed residues of the parent plus chlorinated metabolites in corn grain, residues of parent, chlorinated and hydroxy metabolites are all likely to be non detectable at the current application rates. Therefore, the MARC concluded that the parent and chlorinated metabolites will be an adequate marker for misuse of the pesticide and should be included in the tolerance expression.

Section 9.5  Tolerances to be Established Under 40 CFR § 180.220 ( a)( 2)

This section and Table 20 should be deleted from the human health risk assessment.

Section 10  Data needs/ Label Requirements Section 10.2  Residue Chemistry The following changes should be made:

The requirement for tolerances on the hydroxy metabolites of atrazine should be deleted from this section. In addition to the data requirements already listed in this section, a data requirement should be added for submission of analytical methods AG 484 and 596 for testing through the multi residue methods, OPPTS Guideline § 860.1360.

Rotational Crop Issues:

Syngenta submitted data from seven rotational crop field trials conducted in Regions 1 ( NY; 3 trials), 4 ( MS; 2 trials), and 5 ( IL; 2 trials). A 90% water dispersible granule ( WDG) formulation of atrazine was applied to the primary crop ( field corn) using two treatment regimes. The first treatment regime consisted of a preplant ( or at planting) incorporated application at 2.0 lb ai/ A followed by an over the top postemergence application made 14 20 days later at 0.5 lb ai/ A, for a total application rate of 2.5 lb ai/ A. The second treatment regime consisted of a single preplant ( or at planting) incorporated application made at 1.0 lb ai/ A. Field corn was harvested at normal maturity and the rotational crops, garden pea, lima bean, and potato, were planted  9 and  10 months following the last treatment to the primary crop. The submitted limited rotational field study is acceptable.

Rotational crop samples of garden pea, lima bean, and potato were harvested at normal maturity. Samples were analyzed for residues of atrazine and its chloro metabolites G 30033, G 28279, and G 28273 using GC/ NPD Method AG 484 and for residues of atrazine's hydroxy metabolites GS 17792, GS 17794, and G 34048 using HPLC/ MS/ MS Method 169 99. Residues of atrazine, 5 its chloro metabolites ( G 30033, G 28279, and G 28273), and its hydroxy metabolites ( GS 17792, GS 17794, and G 34048) were each below the analytical method's limit of quantitation (< 0.05 ppm) in/ on potato tubers and shelled succulent peas at plantback intervals of either  9 or  10 months.

Although acceptable, the rotational crop study had some deficiencies. The foliage of the legume and potato vegetables were not analyzed for atrazine residues in the study. Table 1 of OPPTS Residue Chemistry Test Guidelines lists the leafy tops of legumes, such as soybeans, as feed commodities. Since the registrant intends to have soybeans as a rotational crop after corn additional data on soybean foliage are required. In addition, the treatment regime for corn used in the field accumulation study on potatoes and shelled pea and bean did not include the following regime: 0.5 lbs ai/ A pre emergence followed by a 2.0 lbs ai/ A post emergence for a maximum rate of 2.5 lbs ai/ A. Although the study did include a regime resulting in the maximum labeled seasonal rate of 2.5 lbs ai/ A, the regime used did not include the maximum labeled post emergence rate of 2.0 lbs ai/ A. This treatment regime although only used on ~ 22% of corn acres treated with atrazine may lead to the greatest residues in rotational crops.

The results suggest that a plantback interval of 10 months could be established for potatoes. Even though the foliage of potatoes was not harvested and analyzed, because the foliage of potatoes is not considered an animal feed item, HED recommends the PBI for potatoes be changed to 10 months as requested. The foliage of pea and bean crops were also not harvested and analyzed for atrazine residues. As foliage of some legume vegetables ( soybeans) is considered an animal feedstuff in Table 1 of OPPTS 860.1000, residue data on the foliage of legumes are required before HED can reconsider the established PBI of 12 months. HED recommends that the PBI for legume vegetables represented by shelled pea and bean planted after corn be retained at 12 months as exists on the current label until the registrant conducts and submits field trials on the foliage of legume vegetables ( Crop Group 7) as required in the HED Product and Residue Chemistry Chapter for the Interim Reregistration Eligibility Decision ( iRED) for Atrazine.

The HED Product and Residue Chemistry Chapter of the Interim Reregistration Eligibility Decision ( iRED) for Atrazine requires additional field trials for the foliage of legume vegetables to set a tolerance for inadvertent atrazine residues in soybean forage as described in OPPTS. GLN 860.1900. These field trial data can then be used to set a tolerance for inadvertent residues of atrazine in foliage of legumes used as rotational crops, and used as animal feed. Upon receipt and review of the study HED can reconsider the need for the existing 12 month PBI for legume vegetables. This data requirement is based on quantifiable chlorotriazine residues detected in soybean forage collected from a NY test using a 12 month plant back interval ( PBI). 6 Chlorotriazine residues were detected at 0.08 to 0.12 ppm. In addition, hydroxy triazine residues were detected in soybean forage sample at 0.03 ppm from the 12 month PBI trial in NY.

Drinking Water Risk Estimates Reduction of FQPA Safety Factor and Reassessment of DWLOC Value for use in Human Health Risk Assessment:

HED's April 16, 2002: Revised Human Health Risk Assessment for the Reregistration Eligibility Decision ( RED) document used a screening level approach to identify community water systems ( CWS) with high end seasonal exposures to atrazine and the chlorinated metabolites ( or total chlorotriazines). Under the screening level approach, a drinking water level of comparison ( DWLOC) was established at 12. 5 ppb for total chlorotriazines. This DWLOC is not and was not used as a drinking water standard in the risk assessment, but rather as a screening tool to identify specific community water systems which may be of concern.

In the risk assessment, 37 CWS were identified with 90 day average chlorotriazine concentrations above the screening DWLOC of 12.5 ppb. These CWS were targeted for intensive monitoring, risk mitigation, and probabilistic risk assessments. In addition, this 90 day average screening DWLOC of 12.5 ppb also served as a tool in the risk mitigation process to establish a trigger value by which CWS with potential high end seasonal exposures could be identified in the future based on compliance monitoring data collected under the Safe Drinking Water Act ( SDWA). Data available through the SDWA compliance monitoring typically consist of quarterly samples and are reported as an annual average. HED and EFED considered available data from SDWA compliance monitoring and came to agreement with the registrant on a trigger value of 2.6 ppb based on an annual average concentration in finished water which is considered predictive of the likelihood that a 90 day average during peak use season would exceed the screening DWLOC of 12.5 ppb. CWS identified in the future with potential high end seasonal exposures based on the annual average trigger of 2.6 ppb will receive intensive monitoring under the Memorandum of Agreement between OPP and the registrant. It should be noted that the annual average trigger of 2.6 ppb is for total chlorotriazines. Therefore, all SDWA compliance monitoring data must first be transformed from a value representing atrazine alone, to a concentration which reflects inclusion of degradates of concern using the appropriate seasonal regression equations described in the April 16, 2002 risk assessment document.

The screening level DWLOC of 12.5 ppb is based on an endpoint of 1.8 mg/ kg/ day and a 1000 fold uncertainty factor. The 1000 fold uncertainty factor includes a 10 fold factor for interspecies variation, a 10 fold factor for intraspecies variability, and a 10 fold FQPA safety 7 factor. The 10 fold safety factor was applied to account for the residual uncertainty associated with atrazine's toxic effects on the developing child and the extent and magnitude of exposure to atrazine in drinking water. Therefore, the 10 fold safety factor reflects uncertainties regarding both the hazard and exposure portions of the human health risk assessment.

Community water systems found to be potentially impaired by atrazine, as predicted by exceedences in the transformed SDWA annual average concentration, as compared to the trigger value of 2.6 ppb, will be subject to an intensive monitoring program. This intensive monitoring program will include weekly sampling for atrazine during the use season ( exact time frame to be determined) and biweekly sampling for atrazine during the remainder of the year. Total chlorotriazine concentrations for each sample taken will be estimated through the application of the appropriate quarterly linear regression equations as described in the April 16, 2002 risk assessment document. As a quality assurance/ quality control check on this method of estimation, 10% of the samples taken will be analyzed specifically for the chlorinated degradates: desethyl atrazine, desisopropyl atrazine, and diaminochlorotriazine by GC/ MS to ensure that the regression method of estimation of total chlorotriazines is accurate. This monitoring program will determine the maximum 90 day average chlorotriazine concentration with sufficient accuracy to allow removal of that portion of the 10 fold FQPA safety factor associated with residual uncertainties regarding the extent and magnitude of drinking water exposure, thereby reducing the 10 fold safety factor to 3 fold for the risk assessments conducted in those community water systems for which there is available, reliable drinking water exposure data.

For those specific CWS undergoing or preparing to undergo intensive monitoring, residual uncertainties regarding the extent and magnitude of exposure to chlorotriazines have been removed, therefore supporting a reduction in the FQPA safety factor to 3X. Based on the availability of reliable drinking water exposure data, HED has recalculated the DWLOC ( drinking water level of concern) using a total risk assessment 300 fold uncertainty factor for those CWS currently undergoing or targeted for future intensive monitoring. For these CWS, the DWLOC becomes 37.5 ppb for total chlorotriazines based on an endpoint of 1.8 mg/ kg/ day, and a 300 fold uncertainty factor reflecting a 10 fold factor for interspecies variation, a 10 fold factor for intraspecies variability, and a 3 fold safety factor. The 3 fold safety factor reflects residual uncertainties associated with atrazine's toxic effects on the developing child only. For CWS without intensive monitoring as described above, the screening level DWLOC remains 12.5 ppb for total chlorotriazines.

Probabilistic Risk Assessments for 11 Additional CWS:

Syngenta submitted a probabilistic exposure assessment for 11 additional community water 8 systems ( CWS) identified in the revised human health risk assessment ( April 16, 2002). The exposure assessment was conducted using the same exposure model and methodology as used in the revised human health risk assessment as discussed in Appendix II of that document. For details on how this assessment was conducted please refer to Appendix II of the revised human health risk assessment.

Of the 11 CWS included in this assessment, 7 were identified in the revised risk assessment with potential to exceed levels of concern, i. e., 90 day average concentration of chlorotriazines of 12.5 ppb based on quarterly maximum value of 12.5 ppb or greater as obtained from compliance monitoring data ( PLEX database). The additional 4 CWS were identified with potential to exceed levels of concern, i. e., 90 day average concentration of chlorotriazines of 12.5 ppb based on a screening level deterministic assessment. Probabilistic exposure assessments were not conducted for these 11 CWS previously.

The results of that assessment are presented below.

Results of Risk Analysis of Syngenta' s PRA for 11 CWS: Maximum 99.9th Percentile Exposure Based on a Rolling 90 Day Average and % cPAD* for Populations of Interest CWS Adults 13  50 Children 7  12 Children 1  6 Infants < 1 Exposure mg/ kg/ day % cPAD Exposure mg/ kg/ day % cPAD Exposure mg/ kg/ day % cPAD Exposure mg/ kg/ day % cPAD Omaha, IL1 0.0013 72% 0.0012 66% 0.0020 111% 0.0045 250%

Carthage, IL1 0.00026 14% 0.00023 13% 0.00038 21% 0.00088 49%

Fort Wayne, IN1 0.00034 19% 0.00028 16% 0.00048 27% 0.0012 67%

Marion, KY2 0.0016 89% 0.0015 83% 0.0023 128% 0.0057 317%

Lewisburg, KY2 0.0016 89% 0.0015 83% 0.0023 128% 0.0057 317%

Dearborn, MO2 0.0028 155% 0.0027 150% 0.0041 228% 0.01 555%

Drexel, MO2 0.00042 22% 0.00041 22% 0.00063 33% 0.0015 83%

Village of Mt. Orab, OH1 0.0011 62% 0.0009 52% 0.0016 89% 0.0036 200%

Village of Williamsburg, OH1 0.0015 83% 0.0013 72% 0.0022 122% 0.0052 289%

Clermont Co., OH1 0.0007 39% 0.0007 39% 0.0011 61% 0.0026 144% Results of Risk Analysis of Syngenta' s PRA for 11 CWS: Maximum 99.9th Percentile Exposure Based on a Rolling 90 Day Average and % cPAD* for Populations of Interest CWS Adults 13  50 Children 7  12 Children 1  6 Infants < 1 Exposure mg/ kg/ day % cPAD Exposure mg/ kg/ day % cPAD Exposure mg/ kg/ day % cPAD Exposure mg/ kg/ day % cPAD 9 Delaware, OH1 0.0009 50% 0.0007 39% 0.0013 72% 0.0028 155%

1 Identified in April 16, 2002, " Atrazine. HED's Revised Human Health Risk Assessment for the Reregistration Eligibility Decision ( RED)" as one of 52 additional CWS using surface water with potential to exceed levels of concern, i. e., 90 day average concentration of chlorotriazines of 12.5 ppb based on quarterly maximum value of 12.5 ppb or greater as obtained from compliance monitoring data ( PLEX DATABASE).

2 Identified in April 16, 2002, " Atrazine. HED's Revised Human Health Risk Assessment for the Reregistration Eligibility Decision ( RED)" as one of four CWS using surface water with potential to exceed levels of concern, i. e., 90 day average concentration of chlorotriazines of 12.5 ppb based on a screening level deterministic assessment.

* cPAD = 0.0018 mg/ kg/ day and is the chronic population adjusted dose and is used for estimating intermediate term and chronic risks As a result of this probabilistic exposure assessment for these additional 11 CWS, HED has revised the number of CWS with risk estimates exceeding levels of concern. Previously, HED identified 29 CWS using surface water of concern. HED has revised that number to 34 CWS. These 34 CWS are: Shipman, Gillespie, Hettick, Salem, Palmyra Modesto, Hillsboro, Farina, Kinmundy, ADGPTV, Carlinville, West Salem, Flora, Sorento, White Hall, Louisville, Centralia, and Omaha in Illinois, Chariton in Iowa, Iberville in Louisiana, Batesville, Holland, North Vernon, and Scottsburg in Indiana, Lewisburg, and Marion in Kentucky, Bucklin, Dearborn, and Vandalia in Missouri, Newark, Sardinia, Mt. Orab, Williamsburg, Clermont, and Delaware in Ohio.

The CWS added are italicized in the paragraph above, and the CWS removed from the original list is located in Drexel, Missouri. An updated version of Table A  II  1 below contains the names and estimated risks for each CWS with risk estimates of concern at the 99.9th percentile of exposure. [* Note: The CWS located in Shipman, IL is not included in the table below as it no longer serves as a drinking water source. However, it is being retained as a candidate CWS for risk mitigation.] 10 Table A  II  1. Updated from Appendix II of Atrazine: Revised Human Health Risk Assessment. Risk Estimates for High Seasonal Exposures to Atrazine in Finished Drinking Water and Average Dietary Exposure @ the 99.9th Percentile of Exposure* ( Calandex   )

Community Water System ( City/ State) Infant's Exposure ( mg/ kg/ day) % cPAD Children's Exposure ( mg/ kg/ day) % cPAD Adult's Exposure ( mg/ kg/ day) % cPAD Chariton, IA 0.0042 235% 0.0015 < 100% 0.0011 < 100%

Sorento, IL 0.0033 183% 0.0013 < 100% 0.0010 < 100%

Flora, IL 0.0038 211% 0.0017 < 100% 0.0012 < 100%

W. Salem, IL 0.0034 189% 0.0018 100% 0.0014 < 100%

Farina, IL 0.0034 189% 0.0012 < 100% 0.0008 < 100%

White Hall, IL 0.0050 278% 0.0021 117% 0.0014 < 100%

Carlinville, IL 0.0023 128% 0.0011 < 100% 0.0008 < 100%

Gillespie, IL 0.0099 550% 0.0040 222% 0.0031 172%

Hettick, IL 0.0098 544% 0.0040 222% 0.0031 172%

Palmyra Modesto, IL 0.0063 350% 0.0028 155% 0.0020 111%

N. Otter Twp ADGPTV, IL 0.0034 189% 0.0015 < 100% 0.0010 < 100%

Kinmundy, IL 0.0027 150% 0.0011 < 100% 0.0008 < 100%

Salem, IL 0.0095 528% 0.0048 267% 0.0036 200%

Centralia, IL 0.0046 255% 0.0018 100% 0.0013 < 100%

Hillsboro, IL 0.0049 272% 0.0021 117% 0.0015 < 100%

Louisville, IL 0.0062 344% 0.0022 122% 0.0017 < 100%

Holland, IN 0.0044 244% 0.0023 128% 0.0017 < 100%

North Vernon, IN 0.0036 200% 0.0021 117% 0.0014 < 100%

Batesville, IN 0.0047 261% 0.0020 111% 0.0014 < 100%

Scottsburg, IN 0.0048 267% 0.0027 150% 0.0019 105%

Iberville, LA 0.0047 261% 0.0021 117% 0.0015 < 100%

Bucklin, MO 0.0045 250% 0.0018 100% 0.0012 < 100% Table A  II  1. Updated from Appendix II of Atrazine: Revised Human Health Risk Assessment. Risk Estimates for High Seasonal Exposures to Atrazine in Finished Drinking Water and Average Dietary Exposure @ the 99.9th Percentile of Exposure* ( Calandex   )

Community Water System ( City/ State) Infant's Exposure ( mg/ kg/ day) % cPAD Children's Exposure ( mg/ kg/ day) % cPAD Adult's Exposure ( mg/ kg/ day) % cPAD 11 Vandalia, MO 0.0034 189% 0.0019 105% 0.0013 < 100%

Sardinia, OH 0.012 667% 0.0055 305% 0.0037 205%

Marion, KY2 0.0057 317% 0.0023 128% 0.0016 < 100%

Lewisburg, KY2 0.0057 317% 0.0023 128% 0.0016 < 100%

Dearborn, MO2 0.01 555% 0.0041 228% 0.0028 155%

Village of Mt. Orab, OH1 0.0036 200% 0.0016 < 100% 0.0011 < 100%

Village of Williamsburg, OH1 0.0052 289% 0.0022 122% 0.0015 < 100%

Clermont Co., OH1 0.0026 144% 0.0011 < 100% 0.0007 < 100%

Delaware, OH1 0.0028 155% 0.0013 < 100% 0.0009 < 100%

Omaha, IL1 0.0045 250% 0.0020 111% 0.0013 < 100%

Newark, OH 0.0020 111% 0.0009 < 100% 0.0006 < 100%

1 Identified in April 16, 2002, " Atrazine. HED's Revised Human Health Risk Assessment for the Reregistration Eligibility Decision ( RED)" as one of 52 additional CWS using surface water with potential to exceed levels of concern, i. e., 90 day average concentration of chlorotriazines of 12.5 ppb based on quarterly maximum value of 12.5 ppb or greater as obtained from compliance monitoring data ( PLEX DATABASE).

2 Identified in April 16, 2002, " Atrazine. HED's Revised Human Health Risk Assessment for the Reregistration Eligibility Decision ( RED)" as one of four CWS using surface water with potential to exceed levels of concern, i. e., 90 day average concentration of chlorotriazines of 12.5 ppb based on a screening level deterministic assessment.

* cPAD = 0.0018 mg/ kg/ day and is the chronic population adjusted dose and is used for estimating intermediate term and chronic risks 12 The following table provides a listing of CWS and percentages of the PAD exceeded, and the year of the exceedence.

Community Water System ( City/ State) Year( s) of Exceedence Infants < 1 year old % cPAD Children % cPAD Adults % cPAD Chariton, IA 1998 235% < 100% < 100%

Sorento, IL 1996 183% < 100% < 100%

Flora, IL 1996 211% < 100% < 100%

W. Salem, IL 1996 189% 100% < 100%

Farina, IL 1993 189% < 100% < 100%

White Hall, IL 1996 278% 117% < 100%

Carlinville, IL 1996 128% < 100% < 100%

Gillespie, IL 1996 550% 222% 172%

Hettick, IL 1994, 1996, 1998, 2001 544% 222% 172%

Palmyra Modesto, IL 1993, 1994 350% 155% 111%

N. Otter Twp ADGPTV, IL 1993, 1994 189% < 100% < 100%

Kinmundy, IL 1993 150% < 100% < 100%

Salem, IL 1993, 1994 528% 267% 200%

Centralia, IL 1996 255% 100% < 100%

Hillsboro, IL 1994 272% 117% < 100%

Louisville, IL NA 344% 122% < 100%

Holland, IN 1996 244% 128% < 100%

North Vernon, IN 1996 200% 117% < 100%

Batesville, IN 1997 261% 111% < 100%

Scottsburg, IN 1996 267% 150% 105%

Iberville, LA 1996, 1997, 2001 261% 117% < 100%

Bucklin, MO 1997 250% 100% < 100%

Vandalia, MO 1996 189% 105% < 100%

Sardinia, OH 1996 667% 305% 205%

Marion, KY2 1999 317% 128% < 100% Community Water System ( City/ State) Year( s) of Exceedence Infants < 1 year old % cPAD Children % cPAD Adults % cPAD 13 Lewisburg, KY2 1999 317% 128% < 100%

Dearborn, MO2 1994, 1999 555% 228% 155%

Village of Mt. Orab, OH1 1997 200% < 100% < 100%

Village of Williamsburg, OH1 1996 289% 122% < 100%

Clermont Co., OH1 1997 144% < 100% < 100%

Delaware, OH1 1997 155% < 100% < 100%

Omaha, IL1 1996 250% 111% < 100%

Newark, OH NA 111% < 100% < 100%

NA  Not available Additional Compliance Monitoring Data:

Syngenta submitted additional compliance monitoring data for several additional states not submitted or considered in the revised human health risk assessment. These data are summarized below.

Syngenta submitted compliance monitoring data on atrazine and estimates of total chlorotriazines ( atrazine + desethyl atrazine, desisopropyl atrazine, and diaminochlorotriazine) as collected under the Safe Drinking Water Act ( SDWA) for CWS in 10 additional states from 1993 to 1999. These 10 states are considered to have low use of atrazine. These states are: AL, AR, CO, GA, NM, OK, SC, SD, TN, and VA. These 10 states in conjunction with the 21 states previously considered in the revised human health risk assessment represent > 99% of atrazine use. The number of CWS reporting data on atrazine in these 10 additional low use atrazine states varied. Not all of the states provided monitoring data for each of the 7 years between 1993 and 1999. The state of VA provided data for only 1 CWS sampled one time in 1997. The number of CWS collecting data on atrazine decreased with time over the 7 year period. However, between 1993 and 1999, the total number of CWS collecting monitoring data on atrazine across these 10 states ranged from a low of 125 in 1999 to a high of 288 in 1993. The number of samples collected at each of these CWS ranged from 1 to 4 per year.

The maximum concentrations for total chlorotriazines for each CWS for each year of monitoring data provided were compared to 12.5 ppb. None of the samples contained concentrations of 14 total chlorotriazines greater than or equal to 12.5 ppb. Consequently, HED did not identify any additional CWS of potential concern based on compliance monitoring data from these 10 states.

Additional compliance monitoring data were submitted for 1999 for the 21 states originally assessed in the revised human health risk assessment, and for the year 2000 for a combination of states. The maximum concentrations for total chlorotriazines for each CWS for each year of monitoring data provided were compared to 12.5 ppb. Three ( 3) CWS had samples with concentrations of total chlorotriazines greater than or equal to 12.5 ppb. These 3 CWS have been added to the updated version of Table A  III  1 contained in Appendix III of the April 16, 2002 revised human health risk assessment.

The submitted probabilistic exposure assessment also impacted the number of CWS identified as of potential concern as contained in Appendix III of the revised human health risk assessment. As a result of the probabilistic exposure assessment on the 11 CWS, and the additional compliance monitoring data submitted, approximately 50 CWS are now considered to have the potential to exceed 12.5 ppb of chlorotriazines over a consecutive 90 day period. An updated version of Table A  III  1 contained in Appendix III reflecting these changes is provided below.

Table A  III  1. Updated from Appendix III from April 16,2002 Atrazine: Revised Human Health Risk Assessment. Community Water Systems ( CWS) with Quarterly Maximum Concentrations of Atrazine plus Chloro Metabolites Equal to or Greater than 12.5 ppb Year CWS Concentrations ( ppb) Comment 2000 Versailles, IN 15.12 2000 Bedford, IN 13.41 1999 Napoleon, OH 17.35 Self 1999 Corsicana, TX 15.37 1998 Kansas City, KS 14.42 Self 1998 Defiance, OH 13.63 Self 1998 Ayersville, OH 13.63 Purchases from Defiance 1998 Cristi Meadows Subdivision, OH 13.63 Purchases from Defiance 1998 Brunersburg, OH 13.63 Purchases from Defiance 1998 Village of Blanchester, OH 12.47 Self 1998 Glasgow, MO 15.69 Self Table A  III  1. Updated from Appendix III from April 16,2002 Atrazine: Revised Human Health Risk Assessment. Community Water Systems ( CWS) with Quarterly Maximum Concentrations of Atrazine plus Chloro Metabolites Equal to or Greater than 12.5 ppb Year CWS Concentrations ( ppb) Comment 15 1998 Howard Co. PWD # 2 15.69 Purchase from Glasgow 1998 Waverly, IL Self 1997 Newark, OH 29.7 Self 1997 Lake of the Woods 18.1 Self 1997 Napoleon, OH 17.9 Self 1997 Liberty Center, OH 17.9 Purchased water from Napoleon 1997 Florida City, OH 17.9 Purchased water from Napoleon 1997 Village of Malinta, OH 17.9 Purchased water from Napoleon 1997 Aquilla Water Supply District, TX 15.13 Self 1997 Brandon Irene Water Supply Corp. TX 15.13 Self 1997 Chatt Water Supply Corp., TX 15.13 Self 1997 Files Valley Water Corp. 15.13 Self 1997 Hill Co. Water Corp., TX 15.13 Self 1997 Milford City, TX 15.13 Self 1997 City of Bynum, TX 15.13 Self 1997 Piqua, OH 14.31 Self 1996 Napoleon, OH 14.65 Self/ supplier 1996 Louisville, IL 24.3 1996 Osawatomie, KS 17.3 1996 Miami Co. RWD # 1, KS 17.3 Purchased water from Osawatomie 1996 Miami Co. RWD # 3, KS 17.3 Purchased water from Osawatomie 1996 City of Osage, KS 15.84 Self 1996 Osage Co. RWD # 7, KS 15.84 Purchased from City of Osage 1996 City of Reading 15.84 Purchased from City of Osage 1996 Osage Co. RWD # 6, KS 15.84 Purchased from City of Osage Table A  III  1. Updated from Appendix III from April 16,2002 Atrazine: Revised Human Health Risk Assessment. Community Water Systems ( CWS) with Quarterly Maximum Concentrations of Atrazine plus Chloro Metabolites Equal to or Greater than 12.5 ppb Year CWS Concentrations ( ppb) Comment 16 1996 City of Upper Sandusky, OH 14.38 Self 1996 Keysport, IL 14.42 Self 1994 Andersen Co., RWD # 2, KS 15.84 Self 1994 Keysport, IL 18.7 Self 1994 Emma, MO 14.42 Self 1994 Louisville, IL 18.7 Self 1994 Vandali, IL 13.29 Self 1994 Canton 12.71 Self 1994 Cuba, IL 12.71 Purchases from Canton 1994 Norris, IL Purchases from Canton 1994 Dunfer, IL Purchases from Canton 1993 Three Rivers, IN* 20.1 1993 New Haven, IN 20.1 Purchased water from Three Rivers 1993 Sunymede, IN 20.1 Purchased water from Three Rivers The CWS serving Three Rivers, IN was not included in the VMS databases available to HED. 17 Occupational and Residential Exposure and Risk Assessments Based on the registrant's comments received during the 60 day comment period changes have been made to the occupational and residential exposure assessment document. The revised document, " Atrazine: Revised Occupational and Residential Exposure Assessment and Recommendations for the Reregistration Eligibility Decision", August 30, 2002 ( ORE assessment) and the Addendum to the revised ORE assessment ( D287742) dated 1/ 31/ 2003 now reflect those changes. Sections of the atrazine human health risk assessment dated April 16, 2002 must also reflect those changes. Rather than rewrite the human health risk assessment, the appropriate sections to which changes have been made are excerpted here.

Section 4.4  Residential Exposure and Risk Assessment The first paragraph and list of exposure scenarios should now read:

Atrazine is labeled for homeowner use to control weeds in turf grasses that are generally specific to the Southeast, i. e., zyosia, and bermuda grasses. Homeowners applying atrazine products to their lawns may be exposed to atrazine through their skin ( dermal) and by inhaling dusts or sprays ( inhalation) during application. Residential exposures to atrazine are expected to be short term in duration from 1 day to a maximum of 2 to 3 weeks. Intermediate term exposures greater than 30 days in duration are not anticipated from residential uses of atrazine. The following five residential handler exposure scenarios were evaluated:

( 1) mixing, loading, and applying liquid formulations using a backpack sprayer, ( 2) mixing, loading, and applying liquid formulations with a low pressure hand wand, ( 3) mixing, loading, and applying liquid ( ready to use) formulations with a hose end sprayer, ( 4) mixing, loading, and applying granulated formulations with a push type spreader, ( 5) mixing, loading, and applying granulated formulations with a belly grinder.

Section 4.4.2  Post Application Exposure and Risk Estimates The fourth paragraph should now read:

A total of 8 dermal postapplication exposure scenarios were evaluated. All of these scenarios , involving exposure following application of a liquid and granular formulations, had short term dermal MOEs greater than 300, for high contact activities on turf for children and adults. The lowest MOEs of 310 for children and 510 for adults are based on average residues for the day of application at two sites ( NC and GA) each receiving liquid formulations at 2 lbs ai/ A. Residues 18 had dissipated sufficiently on the day after treatment to raise MOEs for children to 750 and adults to 1300. For adults golfing and mowing on treated turf, all short term dermal MOEs exceeded 300.

The sixth paragraph has been expanded to the following:

Adults may reasonably be expected to perform more than one activity on treated lawns in a single day, but an eight hour duration of exposure is unlikely. Therefore, it is reasonable to aggregate the exposures from playing/ gardening ( highest exposure rate), walking, and mowing ( lower exposure rate) for a single MOE. The MOE for all adult post application exposures aggregated from liquid applications at 2 lbs ai/ A is 460 and is above HED's level of concern. It is also possible that an adult would apply herbicide spray to a lawn and then play on it or mow it later that day. In such an event, the aggregated dermal MOE for the day would be slightly lower than the target 300 for that day. Based on the liquid application study values for adult handler and adult post application exposures, the aggregate MOE for dermal exposures is 270. [ See table 14b from the August 30, 2002 document ( 1/[ 1/ 460 + 1/ 640] = 270)]. However, this aggregate exposure scenario is not very likely and is considered a high end estimate of exposure. If the liquid formulation application rates are reduced to 1 lb ai/ A, the resulting MOE for estimates of dermal exposures result in a MOE of 610 for children and greater than 1000 for adults. Combined dermal exposures for adults at a 1 lb ai/ A rate result in a risk estimate of 860 and that does not exceed HED's level of concern. Aggregate risk estimates for adults applying and playing on lawns treated at the 2 lbs ai/ A rate based on the granular residue data do not exceed HED's level of concern.

At the 2 lb ai/ A application rate, incidental oral ( non dietary) risk estimates exceed HED's level of concern for toddlers incidental oral exposures on lawns treated with liquid formulations. Risk estimates are 210 for hand to mouth activity and 200 for combined oral ( non dietary) exposures. Risk estimates do not exceed HED's level of concern for toddlers incidental oral exposures on lawns treated with granular formulations. Risk estimates are 950 for hand to mouth activity and 730 for combined oral ( non dietary) exposures. It is considered reasonably likely that dermal and oral incidental exposures may occur in the same day for children playing on atrazine treated lawns. It can be seen from calculations presented in Table 11 that the incidental hand to mouth exposure estimate constitutes most of the total non dietary oral dose. The overall incidental oral MOE is only slightly less ( 200 for spray, 730 for granular) than the MOE for the hand tomouth estimate ( 210 spray; 950 granular). Since the individual oral route of exposure on sprayed turf exceeds the level of concern, adding the dermal exposure to the oral exposures produces an even lower MOE of 125, which exceeds HED's level of concern. Granular exposures result in a 19 total MOE for dermal plus oral incidental exposures of at least 350, which does not exceed HED's level of concern. These route specific and dermal plus oral aggregated doses and MOEs were calculated for the purposes of the overall risk assessment for this chemical, which will consider all routes of exposure. Finally, ingestion of granules, as explained earlier, is not aggregated because it is considered an infrequent, episodic event.

If the liquid formulation application rates are reduced to 1 lb ai/ A, the resulting MOE for toddlers' hand to mouth exposures is 420, and does not exceed HED's levels of concern. Combined incidental oral exposures for toddlers result in a MOE of 390 and do not exceed HED's levels of concern. As stated, at 1 lb ai/ A risk estimates for dermal exposures result in a MOE of 610 and therefore at 1 lb ai/ A, combined dermal and incidental oral exposures for toddlers ( 1/[ 1/ 610 + 1/ 390]) result in a MOE of 240 for toddlers' aggregate dermal and oral exposures, a highly conservative risk estimate, which is slightly lower than 300.

The seventh paragraph on homeowner use of atrazine 4L in garden corn should be removed/ deleted as the newest labels do not contain this use.

A single label for atrazine 4L ( EPA Reg. No. 829 268) permits professional application to " corn in the home garden." As this was the only such label use found, the potential postapplication risk to residents was not quantitatively assessed; but as the potential risk estimated for postapplication workers was low, the residential risk is also considered low. Atrazine is usually applied when corn is 12" tall.

Tables 10 and 11 summarize these results.

Table 10 should now read: 20 Table 10. Residential Short term Dermal Postapplication Risks for Atrazine ( Using TTR values from liquid and granular Atrazine turf studies  MRID Nos. 449580 01, 449588 01)

Dermal Scenarios Exposure Time ( hours/ day ) Short Term Risks Transfer Coefficienta ( cm2 / hr) MOEs c GA granular GA/ NC liquid ( Avg.) FL granular Non irrig. Irrig. Non irrig. Irrig.

Adult dermal turf contact 2 14,500 4300 3400 510 ( 2 lb ai/ A) 1000 ( 1 lb ai/ A) 1200 21,000 Child dermal turf contact 2 5,200 2600 2000 310 ( 2 lb ai/ A) 610 ( 1 lb ai/ A) 690 13,000 Adult walking, playing golf 4 500 62,000 49,000 7400 ( 2 lb ai/ A) 14,800 ( 1 lb ai/ A) 17,000 310,000 Adult push mowing lawn 2 500 120,000 98,000 15,000 ( 2 lb ai/ A) 30,000 ( 1 lb ai/ A) 34,000 620,000 a Transfer coefficient from revisions to Residential SOP' s ( 02/ 01).

b TTR source: liquid and granular turf studies MRID # 449580 01, 449588 01, DAT 0 1 residue ( see Table 9). The average DAT 0 residue was used and calculated from 2 sites across 2 time points for each site ( 0 and 0.5 days ). All formulations in the studies were applied at a rate of 2 lb ai/ acre. c MOE = Short term NOAEL ( 104 mg/ kg/ day) / dermal dose where dermal dose = TTR ( µ g/ cm2 ) x TC ( cm2 / hr)

x conversion factor ( 1 mg/ 1,000 µ g) x exposure time ( 2 hrs/ day) / body weight ( 70 kg adult or 15 kg 1 to 6 year old).

Notes: TTR = Turf Transferable Residue. Short term NOAEL of 104 mg/ kg/ day reflects 6% dermal absorption factor applied to 6.25 mg/ kg/ day short term oral endpoint.

Table 11 should read as follows: 21 Table 11. Residential Short term Oral Nondietary Postapplication Risks to Children ( 1 6) from " Hand to Mouth" and Ingestion Ex posure When Reentering Lawns Treated with Granular or Liquid Atrazine Formulations Type of Exposure Applicati on Ratea ( lb ai/ acre) Ingestion Rate or Other Assumptionsb Oral Dosec ( mg/ kg/ day) MOEd Hand to Mouth Activity liquid 2 Residential SOPs 0.030 0.015 ( 1 lb ai/ A) 210 420 granular Atrazine Granular Hand Press Study 0.0066 950 Turfgrass/ Object Mouthing 2 liquid or granular Residential SOPs 0.0019 3300 1 liquid Residential SOPs 9.5 x 10 4 6600 Ingestion of Soil 2 liquid or granular Residential SOPs 1.0E 4 62,500 1 liquid Residential SOPs 5 x 10 5 130,000 Total of the Oral Exposures Abovee Liquid formulation 0.032 ( 2 lb ai/ A) 0.016 ( 1 lb ai/ A) 200 390 Granular formulation 0.0086 730 Incidental Ingestion of Granules 0.42% ai 0.2 0.4 g/ day ( 100 200 lbs formulation / acre) 0.056 0.11 57 110 1.5% ai 0.2 0.4 16 31 Table 11. Residential Short term Oral Nondietary Postapplication Risks to Children ( 1 6) from " Hand to Mouth" and Ingestion Ex posure When Reentering Lawns Treated with Granular or Liquid Atrazine Formulations Type of Exposure Applicati on Ratea ( lb ai/ acre) Ingestion Rate or Other Assumptionsb Oral Dosec ( mg/ kg/ day) MOEd 22 Footnotes:

a Application rates represent maximum label rates from current EPA registered labels of 2 lb ai/ A. b Assumptions from Draft Residential SOP' s ( 1997, revised 2/ 01).

c Oral doses calculated using formulas presented in the Residential SOPs ( December, 1999). Shortterm doses were calculated using the following formulas. Hand to mouth; in the absence of DFR data, Revised Residential SOPs ( 02/ 01) are used: oral dose to child ( 1 6 year old) on the day of treatment ( mg/ kg/ day) = [ application rate ( lb ai/ acre) x fraction of residue dislodgeable with potentially wet hands ( 5%) x 11.2 ( conversion factor to convert lb ai/ acre to µ g/ cm2)] x median surface area for 1 3 fingers ( 20 cm2/ event) x hand to mouth rate ( ST: 20 events/ hour) x 50% saliva extraction factor x exp. time ( 2 hr/ day) x 0.001 mg/: g] / bw ( 15 kg child ). For granular formulations, the atrazine granular hand press study data ( MRIDs 45622310, 45622311) were used: the average moistened hand mouth granular residue transfer rate of 1.1% of the ai application rate. Grass/ object mouthing; oral dose to child ( 1 6 year old) on the day of treatment ( mg/ kg/ day) = [ application rate ( lb ai/ acre x 11.2 ( conversion factor to convert lb ai/ acre to µ g/ cm2)) x fraction of residue dislodgeable ( 5%) x ingestion rate of grass ( 25 cm2/ day) x .001 mg/: g] / bw ( 15 kg child ). Soil ingestion; oral dose to child ( 1 6 year old) on the day of treatment ( mg/ kg/ day) = [( application rate ( lb ai/ acre) x fraction of residue retained on uppermost 1 cm of soil ( 100% or 1.0/ cm) x 4.54E+ 08 µ g/ lb conversion factor x 2.47E 08 acre/ cm2 conversion factor x 0.67 cm3/ g soil conversion factor) x 100 mg/ day ingestion rate x 1.0E 06 g/ µ g conversion factor] / bw ( 15 kg). Short term dose based residue on the soil on day of application. Granular pellet ingestion: ( mg/ kg/ day) oral dose to child ( 1 6 year old) = [ Granule ingestion rate ( 0.2 0.4 g/ day) x Fraction of ai of granule formulations x 1,000 mg/ g] / bw ( 15 kg). d Oral MOE = Oral NOAEL ( 6.25 mg/ kg/ day for short term assessments) / Oral Dose ( mg/ kg/ day). Oral NOAEL determined from a rat study. MOEs are reported to two significant figures; target MOE is at least 300. e Combined MOE may be obtained by dividing oral NOAEL by sum of oral doses, or by taking the inverse of the sum of the inverses of the MOEs: Combined MOE = 1/[ 1/ MOE1 + 1/ MOE2 etc.] 23 Section 5.0  Aggregate Risk Assessments and Risk Characterization Section 5.3.2  Short Term Aggregate Risk Estimates for Toddlers' Post Application Exposures This section should now read:

Liquid Formulations Aggregate risk estimates for liquid formulations applied at 2 lb ai/ A for short term hand tomouth exposures result in a MOE of 210 and exceed HED's level of concern. HED estimates that toddlers' exposures from individual and aggregated pathways for incidental oral exposures exceed HED's levels of concern with a MOE of 200 based on combined exposures from hand tomouth transfer of residues, grass and soil ingestion activities by toddlers on grass. Dermal exposures for toddlers' result in a MOE of 310 on grass. Toddlers' short term individual and aggregate incidental exposures each have MOEs less than 300 for liquid formulations. Any addition ( or aggregation) of combined exposures through the dermal, dietary ( food and drinking water) or incidental oral pathways would result in risk estimates that further exceed HED's level of concern for toddlers. Consequently, the short term DWLOC is zero for aggregated exposures from liquid formulations at 2 lb ai/ A across multiple exposure routes for toddlers, indicating risks exceeding HED's level of concern. See Table 13a.

If the liquid formulation application rates are reduced to 1 lb ai/ A, the resulting MOE for toddlers' hand to mouth exposures is 420, and does not exceed HED's levels of concern. Combined incidental oral exposure for toddlers result in a MOE of 390 and does not exceed HED's levels of concern. At 1 lb ai/ A risk estimates for dermal exposures result in a MOE of 610. At 1 lb ai/ A, combined dermal and incidental oral exposures for toddlers ( 1/[ 1/ 610 + 1/ 390]) result in a MOE of 240 for toddlers' aggregate dermal and oral exposures, a highly conservative risk estimate, which is slightly lower than 300. Consequently, at a reduced rate of 1 lb ai/ A, the short term DWLOC is zero for aggregated exposures from liquid formulations across multiple exposure routes for toddlers, indicating risks exceeding HED's level of concern. HED has identified one CWS where short term drinking water exposures combined with short term residential exposures result in short term aggregate risk estimates exceed HED's level of concern. However, because of the conservative nature of the aggregate risk estimates for residential exposures and the limited use pattern for atrazine turf products, i. e., the Southeast, the coincidence of high end home lawn use exposures with high end drinking water exposures are anticipated to be limited.

Granular Formulations Toddlers' risk estimates from individual or aggregated ( combined) pathways for incidental oral 24 exposures based on granular formulations do not exceed HED's levels of concern; i. e., a MOE of 730. Toddlers' risk estimates from dermal exposures based on granular formulations also do not exceed HED's levels of concern; i. e., MOEs of 690 ( for applications that are not watered in immediately after application and 2000 for applications that are watered in immediately after application). Combined dermal and incidental oral exposures result in a MOE of 350 or greater and do not exceed HED's level of concern [ 1/( 1/ 690 + 1/ 730) = 350]. Short term DWLOCs for toddlers' post application aggregate exposures do not exceed HED's level of concern for granular formulations watered in after application to turf. Short term DWLOCs for toddlers' post application aggregate exposures exceed HED's level of concern for granular formulations that are not watered in after application to turf. HED recommends changes to granular products requiring homeowners to water in applications to turf. See table 13a.

Exposure to atrazine through ingestion of granules by toddlers result in MOEs of 16 to 110. Granule ingestion by toddlers is considered an episodic event ( a stand alone incident) and has not been aggregated with either other incidental oral exposures or dermal and dietary exposures.

Table 13a. Aggregate DWLOC Based on High end Residential Post application Short Term Exposures for Toddlers on Turf Grass Treated with Liquid and Granular Formulations of Atrazine Type of Exposure Formulation/ Application Rate ( lbs ai/ acre) Dietary Dose* ( mg/ kg/ day ) Absorbed Dermal Dose ( mg/ kg/ day) Dermal MOE ( mg/ kg/ day) Aggregate Incidental Oral Dose ( mg/ kg/ day ) Aggregate Incidental Oral MOE ST DWLOC ( ppb)

Dermal Contact on Turf 2 lb ai/ acre ( liquid) 0.000017 0.02 310 0.032 200 zero Dermal Contact on Turf 1 lb ai/ acre ( liquid) 0.000017 0.01 610 0.014 390 zero Dermal Contact on Turf 2 lb ai/ acre ( granular) without watering in 0.000017 0.009 690 0.0086 730 12  14*

Dermal Contact on Turf 2 lb ai/ acre ( granular) with watering in 0.000017 0.003 2000 0.0086 730 35  39*

* Depending on toddler body weight assumed either 13 or 15 kg.

In the Midwest, based on available data, weekly concentrations of atrazine and the chlorotriazine metabolites have been measured in drinking water up to 89 ppb. Available drinking water 25 monitoring data for CWS for which 30 day average concentrations can be estimated indicate concentrations up to 60 ppb. However, these high end, short term concentrations do not cooccur with residential uses of atrazine. In the South, residential use of atrazine and high end drinking water exposures may be expected to co occur. Monthly average concentrations of atrazine and the chlorotriazine metabolites range up to 30 ppb in the CWS at Iberville in LA . Therefore, residential use and high end drinking water exposures coincide at Iberville in LA. However, since the highest average short term concentrations of chlorotriazines ( 30 ppb at Iberville) in drinking water co occurring with residential uses is less than the lowest short term DWLOC ( 35 39 ppb), short term aggregate risk estimates based on granular formulations that have been watered in after application do not exceed HED's level of concern for children.

Section 5.3.3  Short Term Aggregate Risk Estimates for Adults' Post Application Exposures This section should now read:

Table 13b summarizes the results of HED's aggregate risk assessment for short term exposures of adults playing on atrazine treated lawns immediately after application. These estimates of risk combine dermal and oral ( dietary) exposures because short term dermal and dietary exposures have a common toxic effect, delayed puberty as a biomarker for neuroendocrine effects.

Table 13b. Aggregate DWLOCs Based on High end Residential Post application Short Term Exposures for Adults on Treated Turf Grass Type of Exposure Formulation/ Applicati on Rate ( lbs ai/ acre) Dietary Dose* ( mg/ kg/ day) Dermal Dose ( mg/ kg/ day) Absorbed Dermal Dose ( mg/ kg/ day) Dermal MOE ( mg/ kg/ day ) ST DWLOC* ( ppb)

Dermal Contact 2 lb ai/ acre ( liquid) 0.000003 0.20 0.012 520 130 2 lb ai/ acre ( granular) 0.000003 0.09 0.0054 1200 157 Dermal Contact Walking/ Pla ying Golf 2 lb ai/ acre ( liquid) 0.000003 0.014 0.0008 7800 210 2 lb ai/ acre ( granular) 0.000003 0.0062 0.0004 16,000 215 Dermal Contact Pushing lawn Mower 2 lb ai/ acre ( liquid) 0.000003 0.007 0.0004 16,000 214 2 lb ai/ acre ( granular) 0.000003 0.003 0.00018 35,000 217 26 Table 13b shows short term DWLOC values for adults for exposure scenarios for high contact activities ( gardening/ playing), golfing, and mowing lawns. Based on the available data, monthly average chlorotriazine concentrations in drinking water have been measured up to 30 ppb in the South. Since short term DWLOCs are greater than measured short term concentrations of chlorotriazines in CWS where drinking water and residential exposures may co occur, risk estimates for adults' short term aggregate exposures do not exceed HED's level of concern. Short term DWLOC values for adult post application exposures are based on an average body weight of 70 kg.

Section 7.0  Occupational Risk Assessments Table 14 should be replaced with the table below. This table is Table 8 in the document, " Atrazine: Revised Occupational and Residential Exposure Assessment and Recommendations for the Reregistration Eligibility Decision", August 30, 2002. Please see this document for details. 27 Table 14: Summary of Occupational Short term and Intermediate term Combined Dermal + Inhalation Handler Risks from Atrazine ( Using PHED, ORETF, and Combined PHED/ Handler Study Data)

Exposure Scenario Crop Type Applicati on Rate ( lb ai or lb ai/ gallon & lbs fertilizer)

( a) Area Treated per Day ( Acres or Gallons)

( b) Baseline MOE( c) PPE ( Gloves,

Coveralls,

Respirator) MOE ( d) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE: PHED + Handler Study Data ( f) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE:

PHED + Handler Study Data ( f)

Shortterm ( g) Interme diateterm ( h) Shortterm ( g) Interme diateterm ( h) Short term ( g) Intermediate term ( h)

Mixer/ Loader Mixing/ Loading Liquid Formulations for Aerial Application ( 1a) conifer forests, sugarcane,

conifer ( Christmas tree) farms,

sod farms in FL 4 350 2 0.4 248 61 520 430 130 110 sugarcane 3 350 3 0.7 381 94 800 660 200 160 chemical fallow 3 1,200 1 NA 96 NA 200 170 NA NA 3 350 2 0.6 330 82 690 570 170 140 1.4 1,200 1 NA 206 NA 430 360 NA NA 1 350 5 1.3 708 170 1,500 1,200 370 300 CRP/ grassla nds 2 1,200 1 NA 144 NA 300 250 NA NA 2 350 4 0.9 495 120 1,000 850 260 210 corn, sorghum 2 1,200 1 NA 144 NA 300 250 NA NA 350 4 0.9 495 120 1,000 850 260 210 1 1,200 2 NA 289 NA 610 500 NA NA 1 350 7 2 991 240 2,100 1,700 520 420 sod farms 2 350 4 1 495 120 1,000 850 260 210 Table 14: Summary of Occupational Short term and Intermediate term Combined Dermal + Inhalation Handler Risks from Atrazine ( Using PHED, ORETF, and Combined PHED/ Handler Study Data)

Exposure Scenario Crop Type Applicati on Rate ( lb ai or lb ai/ gallon & lbs fertilizer)

( a) Area Treated per Day ( Acres or Gallons)

( b) Baseline MOE( c) PPE ( Gloves,

Coveralls,

Respirator) MOE ( d) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE: PHED + Handler Study Data ( f) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE:

PHED + Handler Study Data ( f)

Shortterm ( g) Interme diateterm ( h) Shortterm ( g) Interme diateterm ( h) Short term ( g) Intermediate term ( h)

28 Mixing/ Loading Liquid Formulations for Groundboom Application ( 1b) sugar cane,

macadamia nuts, guava,

conifers, sod farms in FL 4 80 8 2 1,084 270 2,300 1,900 560 460 sugarcane 3 80 12 3 1,667 410 3,500 2,900 870 710 chemical fallow 3 450 2 NA 257 NA 540 440 NA NA 3 200 4 1 578 140 1,200 1,000 300 250 1.4 450 4 NA 550 NA 1,200 950 NA NA 1 200 9 2 1,238 310 2,600 2,100 640 530 CRP/ grassla nds 2 450 3 NA 385 NA 810 660 NA NA 2 200 6 2 867 210 1,800 1,500 450 370 corn, sorghum 2 450 3 NA 385 NA 810 660 NA NA 2 200 6 2 867 210 1,800 1,500 450 370 1 450 6 NA 771 NA 1,600 1,300 NA NA 1 200 12 3 1,734 430 3,600 3,000 900 740 roadsides 1 40 62 15 8,669 2,100 18,000 15,000 4,500 3,700 golf course turf, roadsides 2 40 31 8 4,335 1,100 9,100 7,500 2,300 1,800 sod farms 2 80 16 4 2,167 540 4,600 3,700 1,100 920 Mixing/ Loading Liquid Formulations for Rights of Way Sprayer ( 1c) roadsides 1 40 62 15 8,669 2,100 18,000 15,000 4,500 3,700 Table 14: Summary of Occupational Short term and Intermediate term Combined Dermal + Inhalation Handler Risks from Atrazine ( Using PHED, ORETF, and Combined PHED/ Handler Study Data)

Exposure Scenario Crop Type Applicati on Rate ( lb ai or lb ai/ gallon & lbs fertilizer)

( a) Area Treated per Day ( Acres or Gallons)

( b) Baseline MOE( c) PPE ( Gloves,

Coveralls,

Respirator) MOE ( d) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE: PHED + Handler Study Data ( f) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE:

PHED + Handler Study Data ( f)

Shortterm ( g) Interme diateterm ( h) Shortterm ( g) Interme diateterm ( h) Short term ( g) Intermediate term ( h)

29 bermuda grass rights of way 2 40 31 8 4,335 1,100 9,100 7,500 2,300 1,800 Mixing/ Loading Liquid Formulations for Lawn Handgun Application ( LCO) ( 1d) lawns, golf courses 2 100 12 3 1,734 430 3,600 3,000 900 740 Mixing/ Loading / Incorporating Liquid Formulations onto Liquid or Dry Bulk Fertilizer ( 1e) commercial fertilizer for corn, sorghum:

* PHED data 2 960 tons See Engineering Controls 64 NA 500 tons See Engineering Controls 120 36 * Helix study data 500 tons See Engineering Controls 170 67 commercial fertilizer for corn, sorghum:

* PHED data 1 960 tons See Engineering Controls 120 NA 500 tons See Engineering Controls 230 72 * Helix Study data 500 tons See Engineering Controls 350 130 Table 14: Summary of Occupational Short term and Intermediate term Combined Dermal + Inhalation Handler Risks from Atrazine ( Using PHED, ORETF, and Combined PHED/ Handler Study Data)

Exposure Scenario Crop Type Applicati on Rate ( lb ai or lb ai/ gallon & lbs fertilizer)

( a) Area Treated per Day ( Acres or Gallons)

( b) Baseline MOE( c) PPE ( Gloves,

Coveralls,

Respirator) MOE ( d) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE: PHED + Handler Study Data ( f) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE:

PHED + Handler Study Data ( f)

Shortterm ( g) Interme diateterm ( h) Shortterm ( g) Interme diateterm ( h) Short term ( g) Intermediate term ( h)

30 on farm fertilizer for corn, sorghum 2 160 8 NA 700 NA 1,900 NA NA NA 1 160 15 NA 1,400 NA 3,800 NA NA NA Mixing/ Loading Dry Flowable ( Water Dispersible Granule) for Aerial ( 2a) conifer forests, sugarcane,

conifer ( Christmas tree) farms,

turf for sod in FL 4 350 66 16 105 26 380 130 sugarcane 3 350 100 25 161 40 580 140 chemical fallow 3 1,200 26 NA 41 NA 150 NA 3 350 88 22 140 35 500 120 chemical fallow 1.4 1,200 55 NA 87 NA 320 NA 1 350 190 47 300 74 1,100 270 CRP/ grassla nds 2 1,200 38 NA 61 NA 220 NA 2 350 130 33 210 52 750 190 corn, sorghum 2 1,200 38 NA 61 NA 220 NA 2 350 130 33 210 52 750 190 1 1,200 77 NA 122 NA 440 NA 1 350 260 65 420 100 1,500 370 sod farms 2 350 130 33 210 52 750 190 Table 14: Summary of Occupational Short term and Intermediate term Combined Dermal + Inhalation Handler Risks from Atrazine ( Using PHED, ORETF, and Combined PHED/ Handler Study Data)

Exposure Scenario Crop Type Applicati on Rate ( lb ai or lb ai/ gallon & lbs fertilizer)

( a) Area Treated per Day ( Acres or Gallons)

( b) Baseline MOE( c) PPE ( Gloves,

Coveralls,

Respirator) MOE ( d) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE: PHED + Handler Study Data ( f) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE:

PHED + Handler Study Data ( f)

Shortterm ( g) Interme diateterm ( h) Shortterm ( g) Interme diateterm ( h) Short term ( g) Intermediate term ( h)

31 Mixing/ Loading Dry Flowables ( water dispersible) for Groundboom Application ( 2b) sugar cane,

macadamia nuts, guava,

conifers, sod farms in FL 4 80 290 71 459 110 1,600 410 sugarcane 3 80 440 110 706 170 2,500 630 chemical fallow 3 450 68 NA 109 NA 400 NA 3 200 150 38 245 61 880 220 1.4 450 150 NA 233 NA 840 NA 1 200 330 82 525 130 1,900 470 CRP/ grassla nds 2 450 100 NA 163 NA 580 NA 2 200 230 57 367 91 1,300 330 corn, sorghum 2 450 100 NA 163 NA 580 NA 2 200 230 57 367 91 1,300 330 1 450 210 NA 326 NA 1,200 NA 1 200 460 110 734 180 2,600 650 roadsides 1 40 2,300 570 3,672 910 13,000 3,300 2 40 1,200 290 1,836 450 6,600 1,600 golf course turf 2 40 1,200 290 1,836 450 6,600 1,600 sod farms 2 80 580 140 918 230 3,300 820 Table 14: Summary of Occupational Short term and Intermediate term Combined Dermal + Inhalation Handler Risks from Atrazine ( Using PHED, ORETF, and Combined PHED/ Handler Study Data)

Exposure Scenario Crop Type Applicati on Rate ( lb ai or lb ai/ gallon & lbs fertilizer)

( a) Area Treated per Day ( Acres or Gallons)

( b) Baseline MOE( c) PPE ( Gloves,

Coveralls,

Respirator) MOE ( d) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE: PHED + Handler Study Data ( f) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE:

PHED + Handler Study Data ( f)

Shortterm ( g) Interme diateterm ( h) Shortterm ( g) Interme diateterm ( h) Short term ( g) Intermediate term ( h)

32 Mixing/ Loading Dry Flowables ( water dispersible) for Rights of Way ( 2c) roadsides 1 40 2,300 570 3,672 910 13,000 3,300 2 40 1,200 290 1,836 450 6,600 820 Loading Granular Formulations ( 3) sod farms 2 80 1,200 310 5,023 1,200 62,000 15,000 golf course turf 2 40 2,500 610 10,047 2,500 120,000 31,000 Applicator Spraying Liquids with Aircraft ( 4) conifer forests, sugarcane,

conifer ( Christmas tree) farms,

sod farms in FL 4 350 See Engineering Controls See Engineering Controls 850 210 sugarcane 3 350 1,300 320 chemical fallow 3 1,200 330 NA 3 350 1,100 280 1.4 1,200 710 NA 1 350 2,400 600 CRP/ grassla nds 2 1,200 500 NA 2 350 1,700 420 Table 14: Summary of Occupational Short term and Intermediate term Combined Dermal + Inhalation Handler Risks from Atrazine ( Using PHED, ORETF, and Combined PHED/ Handler Study Data)

Exposure Scenario Crop Type Applicati on Rate ( lb ai or lb ai/ gallon & lbs fertilizer)

( a) Area Treated per Day ( Acres or Gallons)

( b) Baseline MOE( c) PPE ( Gloves,

Coveralls,

Respirator) MOE ( d) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE: PHED + Handler Study Data ( f) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE:

PHED + Handler Study Data ( f)

Shortterm ( g) Interme diateterm ( h) Shortterm ( g) Interme diateterm ( h) Short term ( g) Intermediate term ( h)

33 corn, sorghum 2 1,200 See Engineering Controls See Engineering Controls 500 NA 2 350 1,700 420 1 1,200 990 NA 1 350 3,400 840 sod farms 2 350 1,700 420 Groundboom Application ( 5) sugar cane,

macadamia nuts, guava,

conifers, sod farms in FL 4 80 860 210 1,690 420 4,000 2,700 980 620 sugarcane 3 80 1,300 330 2,600 640 6,100 4,100 1,500 950 chemical fallow 3 450 200 51 401 99 940 640 NA NA 3 200 460 110 901 220 2,100 1,400 520 330 1.4 450 440 110 858 210 2,000 1,400 NA NA 1.4 200 990 240 1,931 480 4,500 3,100 1,100 710 CRP/ grassla nds 2 450 310 76 601 150 1,400 950 NA NA 2 200 690 170 1,352 330 3,200 2,100 790 500 corn, sorghum 2 450 310 76 601 150 1,400 950 NA NA 2 200 690 170 1,352 330 3,200 2,100 790 500 corn, sorghum 1 450 610 150 1,202 300 2,800 1,900 NA NA 1 200 1,400 340 2,704 670 6,400 4,300 1,600 990 roadsides 2 40 3,500 850 6,759 1,700 16,000 10,000 3,900 2,500 1 40 6,900 1,700 13,519 3,300 32,000 20,000 7,900 5,000 golf course turf 2 40 3,500 850 6,759 1,700 16,000 10,000 3,900 2,500 Table 14: Summary of Occupational Short term and Intermediate term Combined Dermal + Inhalation Handler Risks from Atrazine ( Using PHED, ORETF, and Combined PHED/ Handler Study Data)

Exposure Scenario Crop Type Applicati on Rate ( lb ai or lb ai/ gallon & lbs fertilizer)

( a) Area Treated per Day ( Acres or Gallons)

( b) Baseline MOE( c) PPE ( Gloves,

Coveralls,

Respirator) MOE ( d) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE: PHED + Handler Study Data ( f) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE:

PHED + Handler Study Data ( f)

Shortterm ( g) Interme diateterm ( h) Shortterm ( g) Interme diateterm ( h) Short term ( g) Intermediate term ( h)

34 sod farms,

conifer ( Christmas tree) farms 2 80 1,700 430 3,380 840 8,000 5,000 2,000 1,200 Rights of Way Sprayer ( 6) roadsides 2 40 67 16 300 74 ND ND ND ND roadsides 1 40 130 33 601 150 ND ND ND ND Applying Liquids with a Handgun ( 7)

( ORETF) lawns, golf courses 2 5 ND ND 980 ( G) 240 ( G) NF NF Applying Impregnated Dry Bulk Granular Fertilizer with Tractor Drawn Spreader( 8) corn, sorghum 2 320 190 NA 660 NA 1,000 NA NA NA 160 380 NA 1,300 NA 1,900 NA NA 1 320 380 NA 1,300 NA 1,900 NA NA 160 900 NA 2,600 NA 4,000 NA NA Applying Granular with a Tractor Drawn Spreader ( 9) corn, sorghum 2 200 610 150 2,221 550 3,200 790 2 80 1,500 380 5,553 1,400 7,900 2000 1 200 1,200 300 4,442 1,100 6,400 1600 1 80 3,000 750 11,100 2,700 16,000 4000 golf course turf 2 40 3,000 750 11,100 2,700 16,000 4000 Mixer/ Loader/ Applicator Table 14: Summary of Occupational Short term and Intermediate term Combined Dermal + Inhalation Handler Risks from Atrazine ( Using PHED, ORETF, and Combined PHED/ Handler Study Data)

Exposure Scenario Crop Type Applicati on Rate ( lb ai or lb ai/ gallon & lbs fertilizer)

( a) Area Treated per Day ( Acres or Gallons)

( b) Baseline MOE( c) PPE ( Gloves,

Coveralls,

Respirator) MOE ( d) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE: PHED + Handler Study Data ( f) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE:

PHED + Handler Study Data ( f)

Shortterm ( g) Interme diateterm ( h) Shortterm ( g) Interme diateterm ( h) Short term ( g) Intermediate term ( h)

35 Backpack Sprayer ( LCO)

( 10) lawns, golf courses 2 5 ND ND 428 110 Not Feasible Low Pressure Handwand

Liquid Formulations ( LCO) ( 11) lawns, golf courses 2 5 7 2 1549 380 Not Feasible Lawn Handgun ( LCO) [ ORETF]

( 12a) Liquid lawns, golf courses 2 5 ND ND 1400 ( G) 340 ( G) Not Feasible ( 12b) WDG ND ND 1100 ( G) 290 ( G)

( 12c) WSP ND ND 920 ( G) 230 ( G)

Granulars with a Push Type Spreader ( LCO)

[ ORETF] ( 13) lawns, golf courses 2 5 1500 380 2100 ( G) 520 ( G) Not Feasible Granulars with a Bellygrinder ( LCO) ( 14) lawns, golf courses 2 1 330 82 616 150 Not Feasible Flagging Table 14: Summary of Occupational Short term and Intermediate term Combined Dermal + Inhalation Handler Risks from Atrazine ( Using PHED, ORETF, and Combined PHED/ Handler Study Data)

Exposure Scenario Crop Type Applicati on Rate ( lb ai or lb ai/ gallon & lbs fertilizer)

( a) Area Treated per Day ( Acres or Gallons)

( b) Baseline MOE( c) PPE ( Gloves,

Coveralls,

Respirator) MOE ( d) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE: PHED + Handler Study Data ( f) Engineering Controls MOE: PHED Data ( e) Engineering Controls MOE:

PHED + Handler Study Data ( f)

Shortterm ( g) Interme diateterm ( h) Shortterm ( g) Interme diateterm ( h) Short term ( g) Intermediate term ( h)

36 Flagging Sprays ( 15) conifer forests, sugarcane,

conifer ( Christmas tree) farms,

sod farms 4 350 310 76 466 120 910 NA 220 NA sugarcane 3 350 480 120 717 180 1,400 350 chemical fallow 3 350 410 100 621 150 1,200 300 chemical fallow 1.4 350 880 220 1,331 330 2,600 640 CRP/ grassla nds 2 350 620 150 931 230 1,800 450 corn, sorghum 2 350 620 150 931 230 1,800 450 corn, sorghum 1 350 1,200 310 1,863 460 3,600 900 sod farms 2 350 620 150 931 230 1,800 450 Footnotes:

a Application rates represent maximum rates determined from EPA registered labels for atrazine. Typical use rates as determined by BEAD were assessed for corn and sorghum ( 1.0 lb ai/ acre), sugarcane ( 2.6 lb ai/ acre) and chemical fallow ( 1.4 lb ai/ acre).

For commercial bulk fertilizer admixture: If two pounds atrazine active ingredient per acre is impregnated onto 400 pounds of fertilizer ( for the 400 37 pounds fertilizer per acre rate), each ton ( 2000 pounds) of fertilizer would require 10 pounds of atrazine active ingredient. Thus, the total amount of active ingredient for 960 tons for the two pound active ingredient per 400 pounds of fertilizer per acre rate is ( 960)( 10) = 9600 pounds of atrazine active ingredient handled per day. Using the registrant supplied upper limit of production, only 500 tons are produced, so ( 500)( 10) = 5000 pounds of atrazine handled per day. PHED data used for closed system liquid admixture. Arithmetic mean of operator exposure data from Helix ( TM) Canadian seed treatment study submitted by Syngenta.

Estimated Application: 320 A/ day estimated for 20 ton commercial truck spreader; 160 A/ day reasonable max for 10 ton truck or on farm equipment.

b Acres treated per day based on Exposure SAC Policy # 9 " Standard Values for Daily Acres Treated In Agriculture," Revised June 23, 2000. Also high acreage estimated from submitted study data 75th percentile for corn = 450 acres/ day. Some high and typical acreage used to characterize short and intermediate term exposure.

c Baseline MOEs: see Occupational Short term and Intermediate term Handler Risks from Atrazine at Baseline Table.

d PPE MOEs: see Occupational Short term and Intermediate term Handler Risks from Atrazine with PPE Risk Mitigation Table.

e Engineering Control MOEs: see Occupational Short term and Intermediate term Handler Risks from Atrazine with Engineering Controls Table.

f Engineering control dermal unit exposure values taken from submitted by Novartis Crop Protection Inc., passive dosimetry data combined with PHED corresponding scenario data MRID 443154 04.

g Short term dermal MOE = NOAEL ( 104 mg/ kg/ day) / daily dose ( mg/ kg/ day).

Dermal daily dose ( mg/ kg/ day) = daily unit exposure ( mg/ lb ai) x application rate ( lb ai/ acre) x amount handled per day ( acres/ day) / body weight ( 70 kg adult for short term and 60 kg adult female  for developmental effects  for intermediate term assessment). For intermediate term dermal dose an absorption factor of 6 percent applies.

Short term inhalation MOE = NOAEL ( 6.25 mg/ kg/ day) / daily dose ( mg/ kg/ day).

Inhalation daily dose ( mg/ kg/ day) = inhalation unit exposure ( µ g/ lb ai) x application rate ( lb ai/ acre) x amount handled per day ( acres/ day) x conversion factor ( 1 mg/ 1,000 µ g) / body weight ( 70 kg adult for short term and 60 kg developmental female for intermediate term assessment).

h Intermediate term dermal and inhalation MOE = NOAEL ( 1.8 mg/ kg/ day based on an oral developmental study) / daily dose ( mg/ kg/ day).

CRP = Conservation Reserve P rogram UNK = Unknown  additional use information needed NA = Not applicable to the specified scenario and/ or duration of exposure NN = Not needed  MOE > 100 at previous risk mitigation level NF = Not feasible  no engineering control known for this application method