UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                            WASHINGTON, D.C.  20460
                                                                      OFFICE OF
                                                            CHEMICAL SAFETY AND
\* MERGEFORMAT
                                                           POLLUTION PREVENTION

MEMORANDUM

DATE:	December 22, 2015

SUBJECT:	Fluopyram:  Human Health Risk Assessment for Proposed New Uses on Crop Subgroup 1B, Subgroup 1C, Crop Group 2, Subgroup 3-07A, Subgroup 3-07B, Subgroup 4A, Subgroup 4B, Subgroup 5A, Subgroup 5B, Subgroup 6A, Subgroup 6B, Dried Beans, Soybean, Subgroup 8-10A, Subgroup 8-10B, Subgroup 9A, Subgroup 9B, Subgroup 10-10, Group 11-10, Subgroup 12-12A, Subgroup 12-12B, Subgroup 12-12C, Subgroup 13-07A, Subgroup 13-07B, Subgroup 13-07F, Subgroup 13-07G, Crop Group 15 (except corn and Rice), Crop Group 16, Subgroup 19A, Dill Seed, Subgroup 20A, Subgroup 20B,  Subgroup 20C, Artichoke (Globe), Hops, and Sugarcane (Rotated).  Amended Tolerance Requests for the Registered Uses due to Crop Group/Subgroup Expansion Requests.  Proposed New Uses on Turf Grass, Ornamentals, and Christmas Trees, and as a Seed Treatment to Peanuts.

PC Code: 080302
DP Barcode: D421926
Decision No.: 492321
Registration Nos.: 432-RLGI; 432-RLGT; 432-RLGA; 432-RLGL; 432-RLGU;  264-1078; 264-1084; 264-1085; 264-1090; 264-1091
Petition No.: 4F8284
Regulatory Action: Section 3 Registration
Risk Assessment Type: Single Chemical/Aggregate
Case No.:  NA
TXR No.: NA
CAS No.: 658066-35-4
MRID No.: NA
40 CFR: §180.661

FROM:	Barry O'Keefe, Senior Biologist/Risk Assessor
		Meheret Negussie, Chemist
		Whang Phang, Senior Toxicologist
		Risk Assessment Branch III
		Health Effects Division (7509P)

THROUGH:	Christine Olinger, Chief
		Risk Assessment Branch III
		Health Effects Division (7509P)

TO:		Tamue Gibson, Risk Manager
		Shaja Joyner, Team Leader
		Fungicide Herbicide Branch
      Registration Division (7505P)

The registrant, Bayer CropScience, is requesting new uses of fluopyram on artichoke (globe), Brassica (cole) leafy vegetables, Brassica (cole) leafy vegetables head and stem subgroup, bulb vegetables, canola, carrot, cereal grains (except rice), citrus, corn (including field, sweet, popcorn, and field corn grown for seed), cotton, cucurbit vegetables, fruiting vegetables, ginseng, grapes and other small vines fruits (except fuzzy kiwifruit), herbs and spices (except black pepper), hops, leafy vegetables, legume vegetables (including soybean), peanut, pome fruits, potato and other root, tuberous and corm vegetables, small berries (caneberries and bushberries), stone fruit, strawberry and other low growing berries, sugar beet, sunflower subgroup, tree nuts; use as a seed treatment to peanuts; turf grass (golf courses, sod farms, sports fields, residential, industrial, municipal, commercial, and other turf grass areas), ornamentals (in residential and commercial settings), and Christmas trees.

The Registration Division (RD) of OPP has requested that the Health Effects Division (HED) evaluate the hazard and exposure data and conduct dietary, aggregate, occupational and residential exposure assessments, as needed, to estimate the risk to human health that will result from the proposed uses of fluopyram.  This memorandum serves as HED's assessment of those exposures.

The toxicology reevaluation was performed by Whang Phang, the drinking water assessment was conducted by Mohammed Ruhman (EPA Environmental Fate and Effects Division (EFED)), the review of the residue chemistry data and the dietary exposure assessment were conducted by Meheret Negussie, and the occupational and residential exposure assessment and aggregate human health risk assessment were conducted by Barry O'Keefe.

                               TABLE OF CONTENTS

1.0	Executive Summary	5
2.0	HED Recommendations	9
2.1	Data Deficiencies	9
2.2	Tolerance Considerations	9
2.2.1	Enforcement Analytical Method	9
2.2.2	International Harmonization	10
2.2.3	Recommended Tolerances	10
2.2.4	Revisions to Petitioned-For Tolerances	16
2.3	Label Recommendations	17
3.0	Introduction	18
3.1	Chemical Identity	19
3.2	Physical/Chemical Characteristics	19
3.3	Pesticide Use Pattern	19
3.4	Anticipated Exposure Pathways	38
3.5	Consideration of Environmental Justice	38
4.0	Hazard Characterization and Dose-Response Assessment	38
4.1	Toxicological Effects	39
4.2	Safety Factor for Infants and Children (FQPA Safety Factor)	40
4.2.1	Completeness of the Toxicology Database	40
4.2.2	Evidence of Neurotoxicity	40
4.2.3	Evidence of Sensitivity/Susceptibility in the Developing or Young Animal	40
4.2.4	Residual Uncertainty in the Exposure Database	40
4.3	Toxicity Endpoint and Point of Departure Selections	41
4.3.1	Dose-Response Assessment	41
4.3.2	Recommendation for Combining Routes of Exposures for Risk Assessment	41
4.3.3	Cancer Classification and Risk Assessment Recommendation	42
4.3.4	Summary of Points of Departure and Toxicity Endpoints Used in Human Risk Assessment	42
5.1	Residues of Concern Summary and Rationale	44
5.2	Food Residue Profile	45
5.3	Water Residue Profile	45
5.4	Dietary Risk Assessment	46
5.4.1	Description of Residue Data Used in Dietary Assessment	46
5.4.2	Percent Crop Treated Used in Dietary Assessment	46
5.4.3	Acute Dietary Risk Assessment	47
5.4.4	Chronic Dietary Risk Assessment	47
5.4.5	Cancer Dietary Risk Assessment	47
5.4.6	Summary Table	47
6.0	Residential (Non-Occupational) Exposure/Risk Characterization	48
6.1	Residential Handler Exposure	48
6.2	Residential Post-application Exposure	48
6.3	Residential Risk Estimates for Use in Aggregate Assessment	49
6.4	Residential Bystander Post-application Inhalation Exposure	50
6.5	Non-Occupational Spray Drift Exposure and Risk Estimates	50
7.0	Aggregate Exposure/Risk Characterization	51
7.1	Acute Aggregate Risk	51
7.2	Short-Term Aggregate Risk	51
7.3	Chronic Aggregate Risk	51
8.0	Cumulative Exposure/Risk Characterization	52
9.0	Occupational Exposure/Risk Characterization	52
9.1	Short-/Intermediate-Term Handler Risk	52
9.2	Short-/Intermediate-Term Post-Application Risk	53
9.2.2	Inhalation Post-application Risk	56
10.0	References	58
Appendix A.  Toxicology Profile	60
A.1	Toxicology Data Requirements	60
A.2	Toxicity Profiles	61
Appendix B.  Physical/Chemical Properties	72
Appendix C.  Review of Human Research	73
Appendix D.  Residential Handler and Post-application Exposure and Risk Estimates	74
Appendix E.  Occupational Handler and Post-application Exposure/Risk Summary Tables	76
Appendix F.  International Residue Limit Status Sheet	84

1.0	Executive Summary

Fluopyram, (N-[2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl]-2-(trifluoromethyl)benzamide) is a broad-spectrum systemic fungicide of the pyridinyl ethylbenzamide group.  It acts by inhibiting succinate dehydrogenase in the cell respiration of fungi.  The mechanism of toxicity in mammals is not clearly defined.

Use Profile
The registrant, Bayer CropScience (BCS), is requesting numerous new uses on agricultural field crops and crop groups be added to the Luna[(R)] Privilege label (4.16 lb ai/gal) [EPA Reg. No. 264-1078] that contains the sole active ingredient (ai) fluopyram.  Additionally, BCS is requesting to add numerous agricultural field crops and crop groups to the following multi-active ingredient labels: 1) Propulse[TM] (1.67 lb ai/gal) [EPA Reg. No. 264-1084] which contains fluopyram and prothioconazole; 2) Luna[(R)] Tranquility (1.04 lb ai/gal) [EPA Reg. No. 264-1085] which contains fluopyram and pyrimethanil; 3) Luna[(R)] Sensation (2.1 lb ai/gal) [EPA Reg. No. 264-1090] which contains fluopyram and trifloxystrobin; and 4) Luna[(R)] Experience (1.67 lb ai/gal) [EPA Reg. No. 264-1091] which contains fluopyram and tebuconazole.

BCS has proposed to establish tolerances on the vast majority of crops.  Furthermore, BCS has requested tolerance amendments as a result of expanding uses from representative commodities to crop groups/subgroups, addition of new uses, and tolerance re-assessment.  The petitioner additionally submitted data from field trials conducted in Europe with a variety of crops, which included data from studies conducted in greenhouses to support greenhouse uses in North America.  Most proposed applications are at a seasonal rate of 0.445 lb a.i./acre with various pre-harvest intervals (PHIs).

BCS is proposing new use patterns: foliar; banded; soil/in-furrow; and chemigation/drip irrigation treatments.  Additionally, for registered potato (foliar), cotton (seed and soil/in-furrow treatment) and soybean (seed treatment) new uses, a combination of seed/soil/in-furrow and foliar treatments are requested.

Additionally, new rotational crop data for sugarcane have been submitted to support a 14-day plantback interval (PBI) in Region 3.  The database is adequate to support the proposals.

In addition, BCS is requesting a new seed treatment use on peanut seeds to be added to the Luna[(R)] Privilege label (4.16 lb ai/gal) [EPA Reg. No. 264-1078].

BCS, is also requesting new non-food uses of fluopyram on several newly proposed labels, including turf grass (golf courses, sod farms, sports fields, residential, industrial, municipal, commercial, and other turf grass areas), ornamentals (in residential and commercial landscapes, interiorscapes, field grown and container ornamentals, in nurseries, and greenhouses, lathhouses, shadehouses, containers and other enclosed structures), fruit and nut trees (including citrus, grapes, pome fruits, stone fruits, and tree nuts), ornamental sunflower, and Christmas trees.  The proposed labels are as follows: 1) Fluopyram 500 SC (4.16 lb ai/gal) [EPA File Symbol 432-RLGI] which contains fluopyram; 2) FLU+TFS SC 500 (2.1 lb ai/gal) [EPA File Symbol 432-RLGT] which contains fluopyram and trifloxystrobin; 3) FLU+TFS SC 32.5 (0.104 lb ai/gal) [EPA File Symbol 432-RLGA] which contains fluopyram and trifloxystrobin; 4) FLU+TFS SC 25 (0.104 lb ai/gal) [EPA File Symbol 432-RLGL] which contains fluopyram and trifloxystrobin; and 5) 13ESP715 3.3 SC (3.34 lb ai/gal) [EPA File Symbol 432-RLUG] which contains fluopyram.

Most of the proposed labels require occupational handlers to wear the following personal protective equipment (PPE): long sleeved shirts, long pants, shoes, socks, and chemical resistant gloves.  However, the FLU+TFS SC 32.5 and FLU+TFS SC 25 labels do not require the use of gloves.  Additionally, the Luna[(R)] Privilege label requires water proof gloves for seed treatment activities and no gloves for baggers and bag sewers.

On all registered and proposed labels the restricted entry interval (REI) is 12 hours.

Fluopyram is currently registered on a variety of agricultural food crops, including apple, cherry (sweet and tart), cotton, dried beans, peanut, potato, strawberry, sugar beets, tree nuts, watermelon, viniferous variety grapes, and for seed treatment to cotton and soybean.  There are no existing residential uses of fluopyram.

Exposure Profile
The proposed uses of fluopyram would result in exposures from both food and drinking water.  There is a potential for short- and intermediate-term occupational dermal and inhalation exposure to fluopyram during handling tasks (mixing, loading, and application) and during post-application activities.  Long-term occupational exposure is not expected for the proposed use patterns associated with fluopyram.  There is a potential for residential short-term dermal and inhalation exposure to fluopyram to adults during handling tasks.  During residential post-application activities there is a potential for short-term dermal exposure to adults, youths, and children and incidental oral exposure to children 1 to <2 years old.

Hazard Characterization
The liver was the target organ following fluopyram exposure across species and exposure durations.  Treatment-related thyroid effects were also observed at dose levels causing adverse liver perturbations in rats and mice.  Decreased body weight was a common clinical finding throughout the toxicology database.  Liver tumors were observed in female rats and thyroid tumors were observed in male mice in chronic feeding studies; however, a nongenotoxic mode of action was adequately demonstrated for the liver and thyroid tumors.  Therefore, the Cancer Assessment Review Committee (CARC) classified fluopyram as "Not Likely to be Carcinogenic to Humans" at doses that do not induce cellular proliferation in the liver or thyroid glands.  Fluopyram is not genotoxic or mutagenic.

HED recommends that the Food Quality Protection Act (FQPA) safety factor be reduced to 1x because there are no residual uncertainties with regard to pre- and postnatal susceptibility, the toxicology database is complete, and there is no evidence of neurotoxicity.

An acute dietary endpoint for the general population (including infants and children) was selected from the acute neurotoxicity study in rats based on decreased motor and locomotor activity (no observed adverse effect level (NOAEL = 50 mg/kg).  Because this effect was reversible within 48 hours and attributed to generalized systemic toxicity, fluopyram is not considered a neurotoxicant.  The chronic dietary endpoint was based primarily on liver and thyroid effects in the chronic toxicity/carcinogenicity study in rats (NOAEL = 1.2 mg/kg/day).  Short- and intermediate-term dermal endpoints were chosen from a dermal toxicity study in rats in which increased prothrombin time and altered cholesterol levels were seen at the limit dose (NOAEL = 300 mg/kg/day).  Short- and intermediate-term inhalation and short-term incidental oral endpoints were selected from the multigeneration reproduction study in rats based on clinical chemistry and kidney effects in the parental generation (NOAEL = 14.5 mg/kg/day).  Inhalation toxicity is assumed to be equivalent to oral toxicity.  The level of concern (LOC) for all exposures is an MOE of 100>

Dietary Exposure (Food and Water)
The residue chemistry data and environmental fate data are adequate to assess human exposure.  The assessments are based on reliable data and are not expected to underestimate exposure/risk.

Acute Dietary:  The estimated acute dietary exposure to fluopyram from food and drinking water is below HED's level of concern (<100%) for all population subgroups.  The acute dietary analysis is an unrefined conservative assessment that includes tolerance residue levels, the assumption of 100% crop treated, and processing factors (empirical and default).  The acute estimated drinking water concentration (EDWC) was incorporated directly into the dietary assessment (97.6 ug/L) and was calculated by PRZM-GW (Pesticide Root Zone Model- Ground Water) modeling.  Combined dietary exposure from food and drinking water at the 95[th] percentile of exposure utilized 19% of the acute population adjusted dose (aPAD) for the general US population, and 35% of the aPAD for children 1-2 years, the population subgroup with the highest estimated acute dietary exposure to fluopyram.

Chronic Dietary:  The estimated chronic dietary exposure to fluopyram from food and drinking water is below HED's level of concern (<100%) for all population subgroups.  The chronic dietary analysis is a refined assessment that includes average field trial residue levels, percent crop treated, and processing factors (empirical and default).  The chronic EDWC was incorporated directly into the dietary assessment (90.5 ug/L) and was calculated by PRZM-GW modeling.  Chronic dietary exposure utilized 31% of the chronic population adjusted dose (cPAD) for the general US population, and 81% of the cPAD for the most highly exposed population subgroup (children 1-2 years).

Residential Exposure
All residential handler risk estimates are not of concern to HED (all margins of exposure (MOEs) >=100), with MOEs ranging from 8,900 to 190,000 for dermal exposures and 260,000 for inhalation exposures.

For treated lawns and turf, all residential post-application risk estimates are not of concern to HED (all MOEs >=100), with dermal post-application MOEs for all life stages ranging from 1,000 to 97,000 and incidental oral post-application MOEs for children 1 to <2 years old ranging from 2,400 to 1,100,000.  For treated gardens, ornamental trees and shrubs, and fruit trees, the dermal post-application MOEs for all life stages range from 2,100 to 33,000 and are not of concern to HED (MOEs >=100).

Aggregate Risk
There is potential for short-term, acute and chronic aggregate exposure to fluopyram.  The aggregate acute and chronic risks are equivalent to the acute and chronic dietary risks and are not of concern.  The short-term aggregate exposure results from dietary (which is considered background exposure) and residential (which is considered primary) exposure pathways.  The short-term aggregate MOEs for small children and for adults are both 1,500, and are therefore not of concern to HED (LOC <100).

Occupational Exposure/Risk
For occupational handlers for agricultural crops, turf, and Christmas trees, all short- and intermediate-term risk estimates resulted in margins of exposure (MOEs) >=100, and therefore, do not exceed HED's level of concern at any level of protection.  For dermal exposures at baseline personal protective equipment (PPE), MOEs range from 410 to 1,500,000.  For dermal exposures with gloves, MOEs range from 2,400 to 1,100,000.  For inhalation exposures, MOEs range from 7,400 to 5,400,000.  For the seed treatment use on peanut seeds, risk estimates for dermal and inhalation short-term occupational handler exposures all resulted in MOEs >=100, and therefore, do not exceed HED's level of concern, with MOEs ranging from 1,400 to 9,200 for dermal exposures and from 1,700 to 17,000 for inhalation exposures.

Short- and intermediate-term dermal post-application exposures and risks to occupational workers were estimated using standard values established by HED, since no chemical-specific data were submitted.  For all occupational post-application scenarios, the dermal MOEs, at day zero following application, do not exceed HED's level of concern (MOEs >=100), with dermal MOEs ranging from 270 to 23,000.  Additionally, several post-application worker scenarios involved with the mechanical harvesting of cotton were assessed.  The dermal exposures to these harvesters of cotton resulted in risk estimate MOEs ranging from 3,100,000 to 17,000,000, which also do not exceed HED's level of concern (MOEs >=100).

Based on the Agency's current practices, a quantitative occupational post-application inhalation exposure assessment was not performed for fluopyram at this time.  If new policies or procedures are put into place, the Agency may revisit the need for a quantitative occupational post-application inhalation exposure assessment for fluopyram.

Restricted Entry Interval (REI):  The 12-hour REI that appears on the proposed labels is adequate to protect for worker exposure.

Review of Human Research
This risk assessment relies in part on data from studies in which adult human subjects were intentionally exposed to a pesticide or other chemical.  These studies (Appendix C) have been determined to require a review of their ethical conduct, and one of these studies is also subject to review by the Human Studies Review Board.  All of the listed studies have received the appropriate review.

Environmental Justice
Potential areas of environmental justice concerns, to the extent possible, were considered in this human health risk assessment, in accordance with U.S. Executive Order 12898, "Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations," http://www.eh.doe.gov/oepa/guidance/justice/eo12898.pdf).

2.0	HED Recommendations

Pending submission of a revised Section B (see Section 2.3, Label Recommendations), a revised Section F (see Section 2.2.3, Recommended Tolerances), and an analytical reference standard (see Section 2.1 under Submittal of Analytical Reference Standards), there are no issues that would preclude granting Section 3 registration for the requested uses of fluopyram and establishing/amending tolerances for fluopyram (both primary and inadvertent) on the requested crops.

2.1	Data Deficiencies

Pending submission of an analytical reference standard, there are no data gaps that need to be fulfilled for the requested actions.

OCSPP 860.1650 Submittal of Analytical Reference Standards
An analytical reference standard for the AE C656948-benzamide metabolite must be submitted.  The registrant is required to submit a reasonable amount of the analytical reference standard for the benzamide.  The reference standard should be sent to the Analytical Chemistry Lab, which is located at Fort Meade, Maryland, to the attention of either Theresa Cole or Thuy Nguyen at the following address:

	USEPA
	National Pesticide Standards Repository/Analytical Chemistry Branch/OPP
	701 Mapes Road
	Fort George G. Meade, MD  20755-5350

(Note that the mail will be returned if the extended zip code is not used.)

2.2	Tolerance Considerations

2.2.1	Enforcement Analytical Method

The German multiresidue method DFG Method S 19, a gas chromatography with mass selective detection (GC/MSD) method, is the method for the enforcement of tolerances for fluopyram residues in/on crop commodities.  The method was previously validated using samples of orange (fruit), oil seed rape (seeds), wheat (grain), lettuce (head) and dry peas (seeds).  For fluopyram in these commodities, the limit of quantitation (LOQ) was 0.01 ppm, and the calculated limit of detection (LOD) was 0.003 ppm.  The method was subjected to independent laboratory validation (ILV) using samples of cabbage (head), wheat (grain), orange (fruit), and oil seed rape (seed) fortified with fluopyram at 0.01 ppm and 0.10 ppm.  The average recoveries were within acceptable limits (70-120%), and relative standard deviations (RSDs) were <20%.

A high performance liquid chromatography method with tandem mass spectrometry detection (HPLC/MS/MS), Method 01079, has been accepted for the enforcement of tolerances for residues of fluopyram and its metabolite, AE C656948-benzamide, in livestock commodities.  The LOQ is 0.01 ppm and the calculated LOD is 0.003 ppm for each analyte in each matrix.  The method was adequately validated using cattle milk, fat, muscle, liver, and kidney, and hen whole egg fortified with fluopyram and AE C656948-benzamide, each at 0.01 and 0.10 ppm.  The method was subjected to ILV using samples of milk, eggs, beef muscle, and beef liver fortified with fluopyram and AE C656948-benzamide, each at 0.01 and 0.10 ppm (D387587, L. Cheng, 09/23/2011).

2.2.2	International Harmonization

The tolerance definitions are harmonized among the US, Canada, and Codex for all plant and livestock commodities.

Harmonization with Codex is not possible because the recommended US tolerances are for crop groups/subgroups and are higher than the Codex maximum residue limits (MRLs) which are established mostly on the representative crops of the crop group/subgroup, except pome fruits, peach subgroup and tree nuts.  The US tolerance on subgroup 13-07F can be increased to 2.0 to harmonize with Canada and Codex (grape) MRL.  There are Codex maximum residue levels MRLs established on berries (blackberry and raspberry 3 ppm), dry beans (0.07 ppm), broccoli and Brussels sprouts (0.3 ppm), head cabbage (0.15 ppm), cauliflower (0.09 ppm), carrot (0.4 ppm), cherry (0.7 ppm), cucumber (0.5 ppm), dried grapes (currants, raisins and sultanas 5 ppm), grapes (2 ppm), lettuce (head and leaf 15 ppm), leek (0.15 ppm), onion bulb (0.07 ppm), peach subgroup (1 ppm), peanut (0.3 ppm), plums (0.5 ppm), pome fruits (0.5 ppm), potato (0.03 ppm), rapeseed (1 ppm), strawberry (0.4 ppm), sugar beet (0.04 ppm), tomato (0.4 ppm), and tree nuts (0.04 ppm).

The established Canadian MRLs and the existing US tolerances are mostly similar.  Canada and the US have received similar petitions and the MRLs are harmonized for almost all proposed crops, except soybean seed, crop subgroup 6C, crop subgroup 8-10A, crop subgroup 9B, crop group 15, herb subgroup 19A, and subgroup 20A (Refer to Appendix F).  Mainly, the differences are due to different use patterns and policies.

The US and Codex/Canadian livestock MRLs are not harmonized due to different diets and different proposed/established uses.

2.2.3	Recommended Tolerances

HED has reviewed the available residue data and has determined the appropriate tolerance levels for residues of fluopyram to be established in/on the following commodities as indicated in Table <IP_ADDRESS>.  The recommended tolerance expression is as stated in 40 CFR §180.661 (a), (b), and (d), and this expression agrees with the S. Knizner Memo of 05/27/2009.

Table <IP_ADDRESS>.	Tolerance Summary for Fluopyram.
Commodity
                           Proposed Tolerance (ppm)
                    Recommended/ Harmonized Tolerance (ppm)
Comments; Correct Commodity Definition
ARTICHOKE, GLOBE
                                     4.00
                                      4.0
Artichoke, globe
Aspirated Grain Fractions
                                     50.00
                                      50
Grain, aspirated grain fractions
PEANUT
                                     0.20
                                     0.20
Peanut
HOPS, Dried Cone
                                     60.00
                                      60
Hop, dried cones
SUGARCANE, cane
                                     0.08
                                     0.08
Sugarcane, cane
Tolerances need to be expressed in terms of indirect or inadvertent residues of fluopyram. Use limited to Region 3.
VEGETABLES ROOT, Except Sugar Beets
                                     0.30
                                     0.30
Vegetable, root, except sugar beet, subgroup 1B
SUGARBEET, ROOTS
                                     0.09
                                     0.10
Sugarbeet, roots
VEGETABLES TUBEROUS and CORM
                                     0.10
                                     0.10
Vegetable, tuberous and corm, subgroup 1C
POTATO, Wet Peel
                                     0.30
                                     0.30
Potato, wet peel
VEGETABLES, leaves of root and tuber
                                     30.00
                                      30
Vegetable, leaves of root and tuber, group 2
VEGETABLES, BULB, Onion, Bulb
                                     0.30
                                     0.40
Onion, bulb, subgroup 3-07A
VEGETABLES, BULB, Onion, green
                                     15.00
                                      15
Onion, green, subgroup 3-07B
VEGETABLES LEAFY, Lettuce, including radicchio
                                      20
                                      40
Leafy greens subgroup 4A
VEGETABLES LEAFY, Spinach, including amaranth, chervil, chrysanthemum, corn salad, cress, dandelion, endive, orach and purslane[1]
                                     40.0

VEGETABLES LEAFY, Celery, including Chinese celery and Swiss chard
                                     20.0
                                      20
Leaf petioles subgroup 4B

VEGETABLES, Head & Stem Brassica,
                                     4.00
                                      4.0
Brassica, head and stem, subgroup 5A
VEGETABLES, Leafy Brassica Greens
                                     50.00
                                      50
Brassica, leafy greens, subgroup 5B
SOYBEAN, seed
                                     0.30
                                     0.30
Soybean, seed
VEGETABLES, Legume, Edible podded
                                     4.00
                                      4.0
Vegetable, legume, edible podded, subgroup 6A
VEGETABLES, Legume, succulent shelled peas and beans
                                     0.20
                                     0.20
Pea and bean, succulent shelled, subgroup 6B
VEGETABLES, Legume, Dried bean, except soybeans and dried peas
                                     0.70
                                     0.15
Bean, dry
VEGETABLES, Fruiting, Tomato subgroup
                                      1.0
                                      1.0
Tomato subgroup 8-10A
VEGETABLES, Fruiting, Pepper/eggplant subgroup
                                      3.0
                                      4.0
Pepper/eggplant subgroup 8-10B
VEGETABLES, Cucurbit, Melon subgroup
                                     0.90
                                      1.0
Melon subgroup 9A
To harmonize with Canada
VEGETABLES, Cucurbit, Cucumber/Squash subgroup
                                     0.60
                                     0.60
Squash/cucumber subgroup 9B
FRUIT, Citrus
                                     0.90
                                      1.0
Fruit, citrus, group 10-10
CITRUS Oil
                                      8.0
                                      8.0
Citrus, oil
FRUIT, Pome
                                     0.80
                                     0.80
Fruit, pome, group 11-10
FRUIT, Stone, Cherry subgroup
                                     2.00
                                      2.0
Cherry subgroup 12-12A
FRUIT, Stone, Peach subgroup
                                     1.00
                                      1.0
Peach subgroup 12-12B
FRUIT, Stone, Plum subgroup
                                     0.50
                                     0.50
Plum subgroup 12-12C
BERRIES AND SMALL FRUIT, Caneberry
                                     5.00
                                      5.0
Caneberry subgroup 13-07A
BERRIES AND SMALL FRUIT, Bushberry
                                     7.00
                                      7.0
Bushberry subgroup 13-07B
BERRIES AND SMALL FRUIT, Small fruit vine climbing, except fuzzy kiwi
                                     1.50
                                      2.0
Fruit, small vine climbing, except fuzzy kiwifruit, subgroup 13-07F
To harmonize with Codex/Canada
RAISIN
                                     4.00
                                      3.0
Grape, raisin
BERRIES AND SMALL FRUIT, Low Growing Berry
                                     2.00
                                      2.0
Berry, low growing, except cranberry, subgroup 13-07G
NUT, Tree
                                     0.04
                                     0.05
Nut, tree, group 14-12
To harmonize with Canada
ALMOND, HULLS
                                     10.00
                                      10
Almond, hulls

GRAIN, Cereal, except rice and sorghum, GRAIN
                                     0.90
                                      4.0
Grain, cereal, group 15, except corn and rice

                                     0.02
Corn, field, grain

                                     0.02
Corn, pop, grain

                                     0.01
Corn, sweet, kernel plus cob with husks removed
Wheat, milled by-products
                                      2.0
                                     None
Covered by the Crop group 15 tolerance
GRAIN, Cereal, except rice, FORAGE, FODDER, HAY and STRAW,
                                     20.00
                                      20
Grain, cereal, forage, fodder and straw, group 16
HERBS AND SPICES and Spices, Herb Subgroup
                                     70.00
                                      40
Herb subgroup 19A
HERBS, Dried
                                     40.00

Dill seed,
Including  -  Caraway seed, celery seed, coriael seed, lovage seed, mustard seed and poppy seed[1]
                                      70
                                      70
Dill, seed; caraway seed; celery seed; coriander, seed; lovage seed; mustard seed; poppy seed
OILSEEDS, RAPESEED (CANOLA)
                                      0.7
                                      5.0
Rapeseed subgroup 20A
OILSEEDS, SUNFLOWER, SEED
                                     0.70
                                     0.70
Sunflower subgroup 20B
OILSEEDS, COTTONSEED
                                     0.80
                                     0.80
Cottonseed subgroup 20C
COTTON, Gin By-products
                                     30.00
                                      30
Cotton, gin byproducts
Tolerances proposed for residues of fluopyram and its metabolite 2-(trifluoromethyl)benzamide, expressed in parent equivalents:
CATTLE MEAT, BY PRODUCTS
                                     40.00
                                      7.5
Cattle, meat byproducts
CATTLE, FAT
                                     4.00
                                     0.70
Cattle, fat
CATTLE, MEAT
                                     4.00
                                     0.80
Cattle, meat
MILK, CATTLE
                                     2.00
                                     0.40
Milk
CHICKEN MEAT, BYPRODUCTS
                                     0.40
                                     0.16
Poultry, meat byproducts
CHICKEN, FAT
                                     0.15
                                     0.04
Poultry, fat
CHICKEN, MEAT
                                     0.10
                                     0.04
Poultry, meat
EGGS, CHICKEN
                                     0.20
                                     0.08
Egg
HOG, BY PRODUCTS
                                     0.40
                                     0.20
Hog, meat byproducts
HOG, FAT
                                     0.04
                                     0.20
Hog, fat
HOG, MEAT
                                     0.04
                                     0.02
Hog, meat
Horse MEAT, BY PRODUCTS
                                     40.00
                                      7.5
Horse, meat byproducts
Horse, FAT
                                     4.00
                                     0.70
Horse, fat
Horse, MEAT
                                     4.00
                                     0.80
Horse, meat
Goat, BY PRODUCTS
                                     40.00
                                      7.5
Goat, meat byproducts
Goat, FAT
                                     4.00
                                     0.70
Goat, fat
Goat, MEAT
                                     4.00
                                     0.80
Goat, meat
Sheep, BY PRODUCTS
                                     40.00
                                      7.5
Sheep, meat byproducts
Sheep, FAT
                                     4.00
                                     0.70
Sheep, fat
Sheep, MEAT
                                     4.00
                                     0.80
Sheep, meat
[1]As per HED SOP 2000.1 Crop Group/Subgroup Field Trial Data translation (9/12/2000

Table <IP_ADDRESS>.  Tolerance Summary for Fluopyram.
Commodity
                          Established Tolerance (ppm)
                              Proposed Tolerance
                                     (ppm)
                        HED-Recommended Tolerance (ppm)
                                   Comments
                        (correct commodity definition)
40 CFR §180.661 (1)
Almond, hull
                                      8.0
                                      10
                                      10
Revoke existing tolerance upon establishing tolerances as indicated above.
Apple
                                     0.30
                            Proposed as crop group
                                     0.80
Revoke existing tolerance upon establishing tolerances as indicated above.
Apple, wet pomace
                                     0.60
                                     None
                                     None
Revoke covered under recommended tolerance as crop group 11.
Bean, dry
                                     0.09
                        Proposed as crop subgroup (0.7)
                                     0.15
Revoke existing tolerance upon establishing tolerances as indicated above.
Beet, sugar, root
                                     0.04
                                     0.09
                                     0.10
Revoke existing tolerance upon establishing tolerances as indicated above.
Cotton, gin byproducts
                                     0.70
                                     30.0
                                      30
Revoke existing tolerance upon establishing tolerances as indicated above.
Cotton, undelinted seed
                                     0.01
                            Proposed as crop group
                                     0.80
Revoke existing tolerance upon establishing tolerances as indicated above.
Cherry
                                     0.60
                           Proposed as crop subgroup
                                      2.0
Revoke existing tolerance upon establishing tolerances as indicated above.
Grape, wine
                                      2.0
                           Proposed as crop subgroup
                                      2.0
Revoke existing tolerance upon establishing tolerances as indicated above.
Nut, tree, group 14
                                     0.05
                                     0.04
                                     0.05
Revoke existing tolerance upon establishing tolerances as indicated above.
Peanut
                                     0.09
                                     0.20
                                     0.20
Revoke existing tolerance upon establishing tolerances as indicated above.
Pistachio
                                     0.05
                            Proposed as crop group
                                     0.05
Revoke existing tolerance upon establishing tolerances as indicated above.
Potato
                                     0.02
                          Proposed as crop subgroup
                                     0.10
Revoke existing tolerance upon establishing tolerances as indicated above.
Potato, processed potato waste
                                     0.08
                                     None
                                     None
Revoke covered under recommended tolerance as crop subgroup 1C.
Soybean, seed
                                     0.04
                                     0.30
                                     0.30
Revoke existing tolerance upon establishing tolerances as indicated above.
Strawberry
                                      1.5
                           Proposed as crop subgroup
                                      2.0
Revoke existing tolerance upon establishing tolerances as indicated above.
Watermelon
                                      1.0
                           Proposed as crop subgroup
                                      1.0
Revoke existing tolerance upon establishing tolerances as indicated above.
40 CFR §180.661 (2)
Cattle, fat
                                     0.05
                                      4.0
                                     0.70
For all (except hog meat), higher tolerances than established were recommended. Revoke existing tolerances upon establishing tolerances as indicated.
Cattle, meat
                                     0.05
                                      4.0
                                     0.80

Cattle, meat byproducts
                                     0.40
                                      40
                                      7.5

Egg
                                     0.06
                                     0.20
                                     0.08

Goat, fat
                                     0.11
                                      4.0
                                     0.70

Goat, meat
                                     0.15
                                      4.0
                                     0.80

Goat, meat byproducts
                                      1.1
                                      40
                                      7.5

Hog, fat
                                     0.02
                                     0.04
                                     0.20

Hog, meat
                                     0.02
                                     0.04
                                     0.02

Hog, meat byproducts
                                     0.03
                                      40
                                     0.20

Horse, fat
                                     0.11
                                      4.0
                                     0.70

Horse, meat
                                     0.15
                                      4.0
                                     0.80

Horse, meat byproducts
                                      1.1
                                      40
                                      7.5

Milk
                                     0.06
                                      2.0
                                     0.40

Poultry, fat
                                     0.03
                                     0.15
                                     0.04

Poultry, meat
                                     0.03
                                     0.10
                                     0.04

Poultry, meat byproducts
                                     0.10
                                     0.40
                                     0.16

Sheep, fat
                                     0.11
                                      4.0
                                     0.70

Sheep, meat
                                     0.15
                                      4.0
                                     0.80

Sheep, meat byproducts
                                      1.1
                                      40
                                      7.5

40 CFR §180.661 (d)  Indirect or inadvertent residues
Canola, seed
                                      1.8

Revoke
Revoke existing tolerance upon establishing tolerances under 40 CFR §180.661 (1)
Grain, cereal, except rice, group 15
                                     0.03

Grain, cereal, forage, fodder and straw, group 16
                                      2.0

Soybean, forage
                                     0.80

Soybean, hay
                                      3.0

Tolerance that Need to be Proposed 40CFR§180.661 (c)  Regional Registration Indirect or inadvertent residues
Sugarcane, cane
                                     None
                                     0.08
0.08
Propose tolerance for Regional Registration (Region 3)

2.2.4	Revisions to Petitioned-For Tolerances

The petitioned for tolerances differ from the recommended tolerances for sugar beet roots, onion bulbs, leafy greens subgroup 4A, crop subgroup 6C, fruiting vegetables (8-10B), melon subgroup 9A, citrus, subgroup 13-07F, raisin, tree nuts, crop group 15,  herb subgroup 19A, dill seed, and subgroup 20A.

For onion bulbs, citrus, tree nuts, crop group 15, rapeseed subgroup 20A, the Organization for Economic Cooperation and Development (OECD) statistical calculation procedures applied to the field trial residue data provided a different value than the proposed values.

For crop group 15 (sorghum) and rapeseed subgroup 20A (canola), the petitioner excluded a field trial as an outlier based on statistical tests.  However, the trials could not be excluded by the Agency since there were no abnormal field conditions.  In addition, for crop group 15, the minimum (sweet corn 0.01 ppm) and the maximum (wheat 0.72 ppm) residues differ by more than 5x.  Therefore, the tolerance level (0.09 ppm) is not appropriate to establish a crop group tolerance.

The proposed tolerance expressions on leafy vegetables and leafy petioles were not appropriate. The available data support a tolerance of 40 ppm for residues of fluopyram in/on crop subgroup 4A and at 20 ppm on crop subgroup 4B.

The petitioner has requested to establish tolerances on dill seed, including caraway seed, celery seed, coriander seed, fennel seed, lovage seed, mustard seed and poppy seed.  The request to translate from dill seed to these commodities is accepted since the exposures from these commodities are insignificant.  However, separate tolerances, at 70 ppm, are needed for dill, seed; caraway seed; celery seed; coriander, seed; lovage seed; mustard seed; and poppy seed.

For harmonization purposes, tolerances for sugar beet roots, melon subgroup 9A, and subgroup 13-07F were slightly increased and tolerances for tree nuts were slightly decreased.

Separate tolerances were proposed for herbs and spices, subgroup 19A and dried herbs.  Only one tolerance is possible for fresh and dried herbs; therefore, the higher value (40 ppm) is recommended.

The proposed grape, raisin tolerance of 4.0 ppm is not supported by the data.  A tolerance of 3.0 ppm needs to be proposed based on the HAFT (0.948 ppm) for grape and processing factor of 2.4.

The proposed tolerance for sugarcane, cane (0.08 ppm) must be revised to be specified in terms of indirect or inadvertent residues of fluopyram for regional registration.

All proposed tolerances for livestock commodities are too high.  The petitioner must propose tolerances as specified above in Table <IP_ADDRESS>.

The proposed tolerances should be revised to reflect the correct commodity definitions as specified above in Table <IP_ADDRESS>.

2.3	Label Recommendations

Some of the proposed products for fluopyram are intended for use by residential applicators on home lawns or residential areas, but require certain clothing and/or PPE to be worn.  Thus, standard assumptions for residential/consumer applicator specific assessments, such as wearing shorts and a t-shirt without PPE like chemical-resistant gloves or respirators, would represent non-compliance with currently registered products.  If products containing fluopyram are meant to be marketed towards and applied by residential handlers on residential turf, ornamentals, fruit trees, or gardens, HED recommends that the label requirements for clothing and/or PPE be reevaluated or separate consumer-specific labels be developed.

The proposed label for EPA Reg. No. 264-1078 must be revised as follows:
 to modify the proposed PHIs for dried bean seeds (crop subgroup 6C) and soybean seed to 14 days;
 to revise "Dried shelled pea and bean" to "Dried shelled bean" under legume vegetables (except soybeans) listing;
 to modify "May be applied broadcast the day of harvest (field and greenhouse uses) with "May be applied broadcast the day of harvest (field uses).
 to add a separate entry for dill seed including (caraway seed, celery seed, coriander seed, fennel seed, lovage seed, mustard seed and poppy seed) with the same use pattern as proposed under the "Herbs and dill seed" listing with a 14-day PHI instead of a 3-day PHI;
 to modify "legume vegetables (including soybeans)" with "legume vegetables (except cowpeas and dried peas); soybeans) throughout the use directions of LUNA PRIVILEGE (labeled uses, rotational crops etc)
 to modify the rotational crop restrictions to replace the statement "Sugarcane and alfalfa may be planted after 14 days" with "Alfalfa may be planted after 14 days and sugarcane may be planted after 14 days in Region 3"
 to remove "Do not graze or feed soybean forage and hay to livestock after treating with Luna Privilege" from the use directions of cotton seed treatment;
 to modify "herbs and spices (except black pepper)" to "herbs (fresh and dried); dill seed including (caraway seed, celery seed, coriander seed, fennel seed, lovage seed, mustard seed and poppy seed)" from the use directions of peanut seed treatment plant back restrictions.

The product labels for EPA Reg. Nos. 264-1084 and 264-1085 must be amended as follows:
 to specify that sugarcane may be rotated 30-days after application in Region 3.
 to modify "legume vegetables (including soybeans)" to "legume vegetables (except cowpeas and dried peas); soybeans) under rotational crops.

The product label for EPA Reg. No. 264-1091 should be amended as follows:
 to modify "legume vegetables (including soybeans)" to "legume vegetables (except cowpeas and dried peas); soybeans) under rotational crops;
 to specify that sugarcane may be rotated 120-days after application in Region 3.
 to delete the sentence "Do not allow livestock to graze treated area for 14 days and do not harvest for food or feed within 14 days of application"  "Under barley; corn (sweet corn, field corn, field corn grown for seed, and popcorn); and wheat use directions. The PHI's for these crops are not 14-days.

The product label for EPA Reg. No. 264-1090 must be amended as follows:
 to correct the listed crops in the Brassica leafy vegetable crop subgroups: (head and stem subgroup): "Chinese cabbage (bok choy)" should be removed; and in the leafy greens subgroup, "Chinese Cabbage" should be revised to "Chinese cabbage (bok choy)"
 to add a separate entry for dill seed including (caraway seed, celery seed, coriander seed, fennel seed, lovage seed, mustard seed and poppy seed) with the same use pattern as proposed under the "Herbs and dill seed" listing with a 14-day PHI instead of a 3-day PHI;
 to specify that sugarcane may be rotated 14-days after application in Region 3.

The product label for EPA Reg. No. 264-1167 must be amended as follows:
 to modify "legume vegetables (including soybeans)" with "legume vegetables (except cowpeas and dried peas); soybeans) under rotational crop restrictions listing
 to modify the rotational crop restrictions to replace the statement "Sugarcane and alfalfa may be planted after 14 days" with "Alfalfa may be planted after 14 days and sugarcane may be planted after 14 days in Region 3"

3.0	Introduction

Fluopyram (AE C656948) is a Group 7 fungicide with a broad spectrum of activity against numerous fungal diseases, including Ascomycetes, leaf spots, molds, scab, Alternaria, Septoria, Monilinia, Botrytis, Sclerotinia, and powdery mildews in a wide range of crops and plants.  Fluopyram represents is a pyridylethylamide and its biochemical mode of action has been shown to rely on the inhibition of the enzyme succinate dehydrogenase (complex II) within the fungal mitochondrial respiratory chain, thus blocking electron transport.

3.1	Chemical Identity

Table 3.1.  Fluopyram Nomenclature.
Chemical structure

Common name
Fluopyram
Company experimental name
AE C656948
IUPAC name
N-[2-[3-chloro-5-(trifluoromethyl)-2-pyridyl]ethyl]-α,α,α-trifluoro-o-toluamide
CAS name
N-[2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl]-2-(trifluoromethyl)benzamide
CAS registry number
658066-35-4
End-use product (EP)
264-1167 Fluopyram ST; 264-1078 Luna(R) Privilege; 264-1084 Propulse; 264-1085 Luna Tranquility; 264-1090 Luna Sensation; 264-1091 Luna Experience
Chemical structure of AE C656948-benzamide metabolite (included in the tolerance expression for livestock commodities)

                         2-(Trifluoromethyl)-benzamide

3.2	Physical/Chemical Characteristics
FLUOPYRAM IS NOT A HIGHLY LIPOPHILIC MOLECULE (log KOW = 3.3) and is not expected to pass the dermal barrier, pass through human milk, or bioaccumulate in significant quantity.  Empirical dermal absorption data estimate that less than 2% is absorbed dermally in humans and metabolism data in rats demonstrate rapid absorption with ~98% elimination with 72 hours of administration.  Fluopyram is persistent in soil (its half-life is 464 days) with very little abiotic degradation.  Fluopyram, the major environmental residue and only compound modeled for drinking water exposure, is mobile, soluble, and stable in water.  A summary of the physical and chemical properties of fluopyram are presented in Appendix B.

3.3	Pesticide Use Pattern

Fluopyram is currently registered on a variety of agricultural food crops, including apple, cherry (sweet and tart), cotton, dried beans, peanut, potato, strawberry, sugar beets, tree nuts, watermelon, viniferous variety grapes, and for seed treatment to cotton and soybean.  There are currently no existing residential uses of fluopyram.

The registrant, Bayer CropScience, is requesting the addition of new uses of fluopyram on registered liquid formulation product labels, as follows:

      1) The Luna[(R)] Privilege label (4.16 lb ai/gal) [EPA Reg. No. 264-1078] contains only the active ingredient fluopyram.  New uses are proposed on artichoke (globe), Brassica (cole) leafy vegetables, bulb vegetables, canola, carrot, cereal grains (except rice), citrus, cotton, cucurbit vegetables, fruiting vegetables, ginseng, grapes and small vines fruits (except fuzzy kiwifruit), herbs and spices (except black pepper), hops, leafy vegetables, legume vegetables (including soybean), peanut, pome fruits, potato and other root, tuberous and corm vegetables, small berries (caneberries and bushberries), stone fruit, strawberry and other low growing berries (except cranberries), sugar beet, sunflower subgroup, and tree nuts.  Additionally, the Luna Privilege label is also proposed for use as a seed treatment to peanuts.

      2) The Propulse[TM] label (1.67 lb ai/gal) [EPA Reg. No. 264-1084] contains the active ingredients fluopyram and prothioconazole.  New uses are proposed on barley, buckwheat, bushberry subgroup, canola, corn, crambe, cucurbit vegetables, field mustard, Indian rapeseed, low growing berries (except strawberries and cranberries), millet (pearl and proso), oats, rapeseed, rye, soybean, triticale, and wheat (spring, durum, and winter).

      3) The Luna[(R)] Tranquility label (1.04 lb ai/gal) [EPA Reg. No. 264-1085] contains the active ingredients fluopyram and pyrimethanil.  New uses are proposed on bulb vegetables, ginseng, lemons, pome fruit, tuberous and corm vegetables, small berries (caneberries and bushberries), stone fruit (except cherries), strawberries and other low-growing berries (except cranberries), and tomato.

      4) The Luna[(R)] Sensation label (2.1 lb ai/gal) [EPA Reg. No. 264-1090] contains the active ingredients fluopyram and trifloxystrobin.  New uses are proposed on artichoke (globe), Brassica (head and stem subgroup), Brassica (leafy greens subgroup), carrot, citrus, cucurbit vegetables, fruiting vegetables, ginseng, grapes and small vines fruits (except fuzzy kiwifruit), herbs and spices (except black pepper), hops, leafy vegetables (leafy greens subgroup), leafy vegetables (leaf petioles subgroup), pome fruits, potato and other root, tuberous and corm vegetables, soybean, stone fruit, strawberry and other low growing berries (except cranberries), and wheat.

      5) The Luna[(R)] Experience label (1.67 lb ai/gal) [EPA Reg. No. 264-1091] contains the active ingredients fluopyram and tebuconazole.  New uses are proposed on barley, bean (fresh and dry, except succulent shelled), bulb vegetable, corn (sweet corn, field corn, field corn grown for seed, and popcorn), cotton, cucurbit vegetables, fruiting vegetables, grapes and small vines fruits (except fuzzy kiwifruit), hops, leafy Brassica greens, okra, pome fruits, soybean, stone fruit, sunflower, and wheat.

Bayer CropScience, is also requesting the registration of several new end-use products containing the following new non-food uses of fluopyram: turf grass (golf courses, sod farms, sports fields, residential, industrial, municipal, commercial, and other turf grass areas), ornamentals (in residential and commercial landscapes, interiorscapes, field grown and container ornamentals, in nurseries, and greenhouses, lathhouses, shadehouses, containers and other enclosed structures), and Christmas trees.  These new end-use product labels also include proposed uses on citrus, grapes and small vine fruits, pome fruits, stone fruits, sunflower, and tree nuts.  All of these uses can be used by occupational, as well as residential, handlers.  The proposed end-use product labels are as follows: 1) Fluopyram 500 SC (4.16 lb ai/gal) [EPA File Symbol 432-RLGI] which contains the active ingredient fluopyram; 2) FLU+TFS SC 500 (2.1 lb ai/gal) [EPA File Symbol 432-RLGT] which contains the active ingredients fluopyram and trifloxystrobin; 3) FLU+TFS SC 32.5 (0.104 lb ai/gal) [EPA File Symbol 432-RLGA] which contains the active ingredients fluopyram and trifloxystrobin; 4) FLU+TFS SC 25 (0.104 lb ai/gal) [EPA File Symbol 432-RLGL] which contains the active ingredients fluopyram and trifloxystrobin; and 5) 13ESP715 3.3 SC (3.34 lb ai/gal) [EPA File Symbol 432-RLUG] which contains the active ingredient fluopyram.

The proposed labels require occupational handlers to wear the following attire and PPE: long sleeved shirts, long pants, shoes, socks, and chemical resistant gloves.  However, the FLU+TFS SC 32.5 and FLU+TFS SC 25 labels do not require the use of gloves.  Additionally, for seed treatment of peanuts, the Luna[(R)] Privilege label requires water proof gloves for seed treatment activities and no gloves for baggers and bag sewers.

On all registered and proposed labels the proposed REI for new uses is 12 hours.

The proposed uses and application rates are described in detail in Table 3.3.1.

Table 3.3.1.  Summary of Proposed Directions for Use of Fluopyram.
Application Timing, Type, and Equip.
                                  Formulation
                                [EPA Reg. No.]
                                     Crops
                               Application Rate
                                   (lb ai/A)
                          Max. No. Applic. per Season
                          Max. Seasonal Applic. Rate
                                   (lb ai/A)
                                      PHI
                                    (days)
                        Use Directions and Limitations
                            Agricultural Use Sites
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
                               Artichoke (globe)
                                0.104 to 0.222
                             (3.2 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 7 to 10 days.

Luna Sensation
(2.1 lb ai/gal) [264-1090]

                                0.0660 to 0.125
                             (4.0 to 7.6 fl oz/A)

Ground, aerial or chemigation
Luna Sensation
(2.1 lb ai/gal) [264-1090]
Brassica Leafy Vegetables Head and Stem Subgroup: Broccoli, Chinese broccoli (Gai Lon), Brussels sprouts, Cabbage, Chinese cabbage (Napa), Chinese cabbage (Bok choy), Chinese mustard cabbage (Gai choy), Cauliflower, Cavalo broccolo, Kohlrabbi.  Including all cultivars and/or hybrids of these.
                                0.0660 to 0.125
                             (4.0 to 7.6 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 7 to 10 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Brassica (cole) Leafy Vegetables: Broccoli, Broccoli raab (Rapini), Brussels sprouts, Cabbage, Cauliflower, Cavalo broccoli, Chinese broccoli (Gai Lon), Chinese cabbage (Bok choy), Chinese cabbage (Napa), Chinese mustard cabbage (Gai choy), Collards, Kale, Mizuna, Mustard greens, Mustard spinach, Rape greens, and Turnip greens.  Including all cultivars and/or hybrids of these.
                                0.104 to 0.222
                             (3.2 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 5 to 10 days.

Luna Sensation
(2.1 lb ai/gal) [264-1090]
Brassica Leafy Vegetables Leafy Greens Subgroup: Broccoli raab (Rapini), Chinese cabbage, Collards, Kale, Mizuna, Mustard greens, Mustard spinach, Rape greens, and Turnip greens.  Including all cultivars and/or hybrids of these.
                                0.0660 to 0.125
                             (4.0 to 7.6 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 7 to 14 days.

Luna Experience
(1.67 lb ai/gal) [264-1091]
Leafy Brassica Greens (Crop Subgroup 5B):  Broccoli raab (rapini), Chinese cabbage (bok choy), Collards, Kale, Mizuma, Mustard greens, Mustard spinach, Rape greens, and Turnip greens,
                                0.0783 to 0.112
                             (6.0 to 8.6 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 7 to 14 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Bulb Vegetables: Chive fresh leaves, Chive fresh leaves (Chinese), Daylily bulb, Elegans hosta, Fritillaria (bulb and leaves), Garlic bulb, Garlib bulb (Great headed and Serpent), Kurrant, Leek, Leek (Lady's and Wild), Lily bulb, Onion (Beltsville bunching, Bulb, Chinese bulb, Fresh, Green, Macrostem, Pearl, Potato bulb, Tree tops, and Welsh), Shallot (bulb and fresh leaves).  Including all cultivars and/or hybrids of these.
                                 0.13 to 0.222
                             (4.0 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 5 to 7 days.

Luna Experience
(1.67 lb ai/gal) [264-1091]
Bulb Vegetables: Chive fresh leaves, Chive fresh leaves (Chinese), Daylily bulb, Elegans hosta, Fritillaria (bulb and leaves), Garlic bulb, Garlic bulb (Great headed and Serpent), Kurrant, Leek, Leek (Lady's and Wild), Lily bulb, Onion (Beltsville bunching, Bulb, Chinese bulb, Fresh, Green, Macrostem, Pearl, Potato bulb, Tree tops, and Welsh), Shallot (bulb and fresh leaves).
                                0.104 to 0.167
                             (8.0 to 12.8 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 10 to 14 days.

Luna Tranquility
(1.04 lb ai/gal) [264-1085]
Bulb Vegetables: Dry Bulb Onion, Eschalots, Green Onion, Garlic, Leeks, Japanese Bunching Onion, Scallions, Shallot, and Spring Onion.
                                0.130 to 0.219
                            (16.0 to 27.0 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 7 to 14 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Canola subgroup: Borage, Crambe, Cuphea, Echium, Flax seed, Gold of pleasure, Hare' ear mustard, Lesquerella, Lunaria, Meadowfoam, Milkweed, Mustard seed, Oil radish, Poppy seed, Rapeseed, Sesame, and Sweet rocket. Including cultivars, varieties, and/or hybrids of these.
                                     0.222
                                (6.84 fl oz/A)
                                      NS
                                     0.446
                                      14
Retreatment interval of 12 to 14 days.
Ground, aerial or chemigation
Propulse
(1.67 lb ai/gal) [264-1084]
            Canola Rapeseed, Indian Rapeseed, Field Mustard, Crambe
                                     0.177
                                (13.6 fl oz/A)
                                      NS
                                     0.446
                                      36
Retreatment interval of 14 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
                                    Carrot
                                0.156 to 0.222
                             (4.8 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 5 to 7 days.  Tops or greens from this crop may be utilized for food or feed.

Luna Sensation
(2.1 lb ai/gal) [264-1090]

                                0.0660 to 0.125
                             (4.0 to 7.6 fl oz/A)

                                       7
Retreatment interval of 14 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Cereal Grains (except Rice): Barley, Buckwheat, Corn (Sweet Corn, Field Corn, Field Corn Grown for Seed, and Popcorn), Millet, (Pearl and Proso), Oats, Rye, Sorghum, Sudan Grass, Teosinte, Triticale, and Wheat.
                                     0.222
                                (6.84 fl oz/A)
                                      NS
                                     0.446
                                      14
Retreatment interval of 14 days.  Do not allow livestock to graze treated area for 14 days and do harvest for food or feed within 14 days of application.
Ground, aerial or chemigation
Propulse
(1.67 lb ai/gal) [264-1084]
                                    Barley
                                     0.177
                                (13.6 fl oz/A)
                                      NS
                                     0.446
                                      32
Retreatment interval of 14 days.

Luna Experience
(1.67 lb ai/gal) [264-1091]
                                    Barley
                                     0.112
                                 (8.6 fl oz/A)
                                      NS
                                     0.446
                                      30
Retreatment interval not specified.  Do not allow livestock to graze treated area for 14 days and do not harvest for food or feed within 14 days of application.
Ground or aerial
Propulse
(1.67 lb ai/gal) [264-1084]
                Buckwheat, Millet (Pearl and Proso), Oats, Rye
                                     0.177
                                (13.6 fl oz/A)
                                      NS
                                     0.446
                                      30

Ground, aerial or chemigation
Propulse
(1.67 lb ai/gal) [264-1084]
                                     Wheat
                                     0.177
                                (13.6 fl oz/A)
                                      NS
                                     0.446
                                      30
Retreatment interval of 14 days.

Luna Sensation
(2.1 lb ai/gal) [264-1090]
                                     Wheat
                                     0.112
                                (6.84 fl oz/A)
                                      NS
                                     0.446
                                      35
Retreatment interval of 14 to 21 days.  If two applications or 0.224 lb ai/A/yr are applied, do not allow livestock to graze within the treated area and do not harvest the treated crop for forage or hay.  If one application or 0.112 lb ai/A/yr are applied, do not allow livestock to graze within the treated area within 30 days after application, and do not harvest the treated crop for forage within 30 days after application or for hay within 45 days after application.

Luna Experience
(1.67 lb ai/gal) [264-1091]
                                     Wheat
                                     0.112
                                 (8.6 fl oz/A)
                                      NS
                                     0.446
                                      30
Retreatment interval not specified.  Do not allow livestock to graze treated area for 14 days and do not harvest for food or feed for 14 days of application.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Forage, Fodder or Straw from Cereal Grains: Barley, Buckwheat, Corn (Sweet Corn, Field Corn, Field Corn Grown for Seed, and Popcorn), Millet, (Pearl and Proso), Oats, Rye, Sorghum, Sudan Grass, Teosinte, Triticale, and Wheat.
                                     0.222
                                (6.84 fl oz/A)
                                      NS
                                     0.446
                                      14
Retreatment interval of 14 days.  Do not allow livestock to graze treated area for 14 days and do harvest for food or feed within 14 days of application.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Citrus: Australian desert lime, Australian finger-lime, Brown River finger lime, Calamondin, Citron, Citrus hybrids, Grapefruit, Japanese summer grapefruit, Kumquat, Lemon, Lime, Mediterranean mandarin, Mount white lime, New Guinea wild lime, Orange (sour and sweet), Pummelo, Russell River lime, Satsuma mandarin, Sweet lime, Tachibana orange, Tahiti lime, Tangelo, Tangerine (Mandarin), Tangor, Trifoliate orange, Uniq fruit, White sapote (Casimiroa spp.) and cultivars, varieties, and/or hybrids of these.
                                0.156 to 0.222
                             (4.8 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 7 to 21 days.  Minimum 30 day interval between soil applications.

Luna Sensation
(2.1 lb ai/gal) [264-1090]
Citrus: Calamondin, Citrus Citron, Citrus hybrids (Citrus spp., includes Chironja, Tangelo and Tangor), Grapefruit, Grapefruit, Kumquat, Lemon, Lime, Mandarin (Tangerine), Orange (Sweet and Sour), Pummelo, Tangelo, Satsuma Mandarin, White Sapote (Casimiroa spp.), and other cultivars and/or hybrids of these.
                                     0.125
                                 (7.6 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 7 to 21 days.

Fluopyram 500 SC
(4.16 lb ai/gal) [264-RLGI]
                                    Citrus
                        0.156 to 0.221 lb ai/100 gal/A
                          4.8 to 6.8 fl oz/100 gal/A
                                      NS
                                 0.446 lb ai/A
                                 13.7 fl oz/A
                                       7
Retreatment interval of 7 to 21 days.  Retreatment interval for nematode control is 30 days.

FLU+TFS SC 500
(2.10 lb ai/gal) [264-RLGT]

                             0.125 lb ai/100 gal/A
                              7.6 fl oz/100 gal/A

                                 0.446 lb ai/A
                                 27.3 fl oz/A

FLU+TFS SC 25
(0.104 lb ai/gal) [264-RLGL]

                             0.125 lb ai/100 gal/A
                              154 fl oz/100 gal/A

                                 0.445 lb ai/A
                                  548 fl oz/A

13ESP715 3.3 SC
(3.34 lb ai/gal) [432-RLUG]

                        0.157 to 0.446 lb ai/100 gal/A
                          6.0 to 17.1 fl oz/100 gal/A

                                 0.446 lb ai/A
                                 17.1 fl oz/A

Ground, aerial or chemigation
Luna Tranquility
(1.04 lb ai/gal) [264-1085]
                                     Lemon
                                     0.219
                                (27.0 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval not specified.  The use of adjuvants is prohibited.
Ground, aerial or chemigation
Propulse
(1.67 lb ai/gal) [264-1084]
Corn (including Field Corn, Sweet Corn, Popcorn, and Field Corn grown for seed)
                                     0.177
                                (13.6 fl oz/A)
                                      NS
                                     0.446
                                      14
                                       0
Retreatment interval of 7 to 14 days.  For field corn, field corn grown for seed, and popcorn, do not apply within 14 days of harvest for grain or fodder.  For sweet corn, do not apply within 14 days of harvest for fodder.  Sweet corn ears and forage may be harvested the same day of application.

Luna Experience
(1.67 lb ai/gal) [264-1091]
     Corn (Sweet Corn, Field Corn, Field Corn Grown for Seed, and Popcorn)
                                     0.167
                                (12.8 fl oz/A)
                                      NS
                                     0.446
                                  See Limits
Retreatment interval of 14 days.  For field corn, field corn grown for seed, and popcorn, may be applied up to 21 days before harvest of forage, and 36 days before the harvest of grain or fodder.  For sweet corn, may be applied within 7 days before harvest of ears or forage, and 49 days before the harvest of fodder.  Do not allow livestock to graze treated area for 14 days and do not harvest for food or feed within 14 days of application.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Cotton Subgroup (20C):  Includes cultivars, varieties and other hybrids of these.
                                0.156 to 0.222
                             (4.8 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                      30
Retreatment interval not specified.

Luna Experience
(1.67 lb ai/gal) [264-1091]
                                    Cotton
                                     0.222
                                (17.0 fl oz/A)
                                      NS
                                     0.446
                                      30
Retreatment interval of 7 to 14 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Cucurbit Vegetables: Chayote (fruit), Chinese waxgourd (Chinese preserving melon), Citron melon, Cucumber, Gherkin (edible, includes Hyotan, Cucuzza, Hechima, Chinese okra), Momordica spp. (includes Balsam apple, Balsam pear, Bitter melon, Chinese cucumber), Muskmelon (hybrids and/or cultivars of Cucumis melo including True cantaloupe, Cantaloupe, Casaba, Crenshaw melon, Golden Pershaw melon, Honeydew melon, Honey balls, Mango melon, Persian melon, Pineapple melon, Santa Claus melon, Snake melon), Pumpkin, Squash (includes Summer Squash types such as: Crookneck squash, Scallop squash, Straight neck squash, Vegetable marrow, Zucchini, and Winter squash types such as Acorn squash, Butternut squash, Calabaza, Hubbard squash, Spaghetti squash), and Watermelon (includes hybrids and/or varieties of Citrullus lanatus).
                                0.104 to 0.222
                             (3.2 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 5 to 14 days; except for soil applications with minimum 5 day interval between soil applications.
Ground or chemigation
Propulse
(1.67 lb ai/gal) [264-1084]
Cucurbit Vegetables: Chayote (fruit), Chinese waxgourd (Chinese preserving melon), Citron melon, Cucumber, Gherkin, Edible gourd (includes hyotan, cucuzza, hechima, Chinese okra), Momordica spp. (includes Balsam apple, Balsam pear, Bitter melon, Chinese cucumber), Muskmelon (includes cantaloupe), Pumpkin, Squash (summer and winter, includes Butternut squash, Calabaza, Hubbard squash, Acorn squash, Spaghetti squash), and Watermelon.
                                     0.177
                                (13.6 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 5 to 10 days.  Only 1 soil application allow; up to two foliar applications allowed.
Ground, aerial or chemigation
Luna Sensation
(2.1 lb ai/gal) [264-1090]
Cucurbit Vegetables: Chayote (fruit), Chinese waxgourd (Chinese preserving melon), Citron melon, Cucumber, Gherkin (edible, includes Hyotan, Cucuzza, Hechima, Chinese okra), Momordica spp. (includes Balsam apple, Balsam pear, Bitter melon, Chinese cucumber), Muskmelon (hybrids and/or cultivars of Cucumis melo including True cantaloupe, Cantaloupe, Casaba, Crenshaw melon, Golden Pershaw melon, Honeydew melon, Honey balls, Mango melon, Persian melon, Pineapple melon, Santa Claus melon, Snake melon), Pumpkin, Squash (includes Summer Squash types such as: Crookneck squash, Scallop squash, Straight neck squash, Vegetable marrow, Zucchini, and Winter squash types such as Acorn squash, Butternut squash, Calabaza, Hubbard squash, Spaghetti squash), and Watermelon (includes hybrids and/or varieties of Citrullus lanatus).
                                0.0660 to 0.125
                             (4.0 to 7.6 fl oz/A)
                                       4
                                     0.446
                                       0
Retreatment interval of 7 to 14 days; except for soil applications with minimum 7 day interval between soil applications.

Luna Experience
(1.67 lb ai/gal) [264-1091]
Cucurbit Vegetables: Chayote (fruit), Chinese waxgourd (Chinese preserving melon), Citron melon, Cucumber, Gherkin (edible, includes Hyotan, Cucuzza, Hechima, Chinese okra), Momordica spp. (includes Balsam apple, Balsam pear, Bitter melon, Chinese cucumber), Muskmelon (hybrids and/or cultivars of Cucumis melo including True cantaloupe, Cantaloupe, Casaba, Crenshaw melon, Golden Pershaw melon, Honeydew melon, Honey balls, Mango melon, Persian melon, Pineapple melon, Santa Claus melon, Snake melon), Pumpkin, Squash (includes Summer Squash types such as: Crookneck squash, Scallop squash, Straight neck squash, Vegetable marrow, Zucchini, and Winter squash types such as Acorn squash, Butternut squash, Calabaza, Hubbard squash, Spaghetti squash), and Watermelon (includes hybrids and/or varieties of Citrullus lanatus).
                                0.0783 to 0.222
                             (6.0 to 17.0 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 10 to 14 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Fruiting Vegetables: African eggplant, Bush Tomato, Cocona, Currant tomato, Eggplant, Garden huckleberry, Goji berry, Martynia, Naranjilla, Okra, Pea eggplant, Pepino, Pepper (Capsicum spp., including Bell, Chili, Cooking, Pimento and Sweet), Roselle, Scarlet eggplant, Sunberry, Tomatillo, Tomato, Tree tomato, and cultivars, varieties, and/or hybrids of these.
                                0.117 to 0.222
                            (3.60 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 7 days.

Luna Sensation
(2.1 lb ai/gal) [264-1090]
Fruiting Vegetables: Eggplant, Groundcherry, Okra, Pepinos, Pepper (Capsicum spp., including Bell, Chili, Cooking, Pimento and Sweet), Tomatillo, and Tomato.
                                0.0825 to 0.125
                             (5.0 to 7.6 fl oz/A)
                                       5
                                     0.446
                                       3
Retreatment interval of 7 to 14 days.

Luna Experience
(1.67 lb ai/gal) [264-1091]
Fruiting Vegetables: African eggplant, Bush Tomato, Cocona, Currant tomato, Eggplant, Garden huckleberry, Goji berry, Martynia, Naranjilla, Pea eggplant, Pepino, Non Bell Pepper, Roselle, Scarlet eggplant, Sunberry, Tomatillo, Tomato, Tree tomato, and cultivars, varieties, and/or hybrids of these.
                                0.0783 to 0.222
                             (6.0 to 17.0 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 7 to 14 days.
Ground, aerial or chemigation
Luna Experience
(1.67 lb ai/gal) [264-1091]
                                     Okra
                                     0.167
                                (12.8 fl oz/A)
                                      NS
                                     0.446
                                       3
Retreatment interval of 14 days.
Ground, aerial or chemigation
Luna Tranquility
(1.04 lb ai/gal) [264-1085]
                                    Tomato
                                    0.0910
                                 (11.2 fl oz/A
                                      NS
                                     0.446
                                       1
Retreatment interval of 7 to 14 days.  For greenhouse uses apply only in well-ventilated plastic tunnel houses or glass houses.  Ventilate for at least 2 hours after application.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
                                    Ginseng
                                     0.222
                                (6.84 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 5 to 7 days.

Luna Sensation
(2.1 lb ai/gal) [264-1090]

                                     0.125
                                 (7.6 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 14 days.

Luna Tranquility
(1.04 lb ai/gal) [264-1085]

                                0.130 to 0.219
                            (16.0 to 27.0 fl oz/A)
                                      NS
                                     0.446
                                      30
Retreatment interval of 7 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Grapes and Small Vine Fruits (except fuzzy kiwifruit): Amur River grape, Gooseberry, Grape, Kiwifruit, Hardy, Maypop, Schisandra berry, and cultivars, varieties, and/or hybrids of these varieties.
                                0.104 to 0.222
                             (3.2 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 12 to 21 days.

Luna Sensation
(2.1 lb ai/gal) [264-1090]

                                0.0660 to 0.125
                             (4.0 to 7.6 fl oz/A)
                                       6
                                     0.446
                                      14
Retreatment interval of 12 to 21 days.

Luna Experience
(1.67 lb ai/gal) [264-1091]

                                0.0783 to 0.112
                             (6.0 to 8.6 fl oz/A)
                                      NS
                                     0.446
                                      14
Retreatment interval of 12 to 21 days.

Luna Tranquility
(1.04 lb ai/gal) [264-1085]

                                0.130 to 0.219
                            (16.0 to 27.0 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 12 to 14 days.
Ground, Drench or Chemigation
Fluopyram 500 SC
(4.16 lb ai/gal) [264-RLGI]
                         Grapes and Small Vine Fruits
                        0.104 to 0.221 lb ai/100 gal/A
                          3.2 to 6.8 fl oz/100 gal/A
                                      NS
                                 0.446 lb ai/A
                                 13.7 fl oz/A
                                       7
Retreatment interval of 12 to 21 days.

FLU+TFS SC 500
(2.10 lb ai/gal) [264-RLGT]

                        0.0656 to 0.125 lb ai/100 gal/A
                          4.0 to 7.6 fl oz/100 gal/A
                                       6
                                 0.446 lb ai/A
                                 27.3 fl oz/A
                                      14
Retreatment interval of 12 to 21 days.

FLU+TFS SC 25
(0.104 lb ai/gal) [264-RLGL]

                        0.0821 to 0.125 lb ai/100 gal/A
                          101 to 154 fl oz/100 gal/A
                                       6
                                 0.445 lb ai/A
                                  548 fl oz/A
                                      14
Retreatment interval of 12 to 21 days.

13ESP715 3.3 SC
(3.34 lb ai/gal) [432-RLUG]

                        0.112 to 0.223 lb ai/100 gal/A
                         4.28 to 8.56 fl oz/100 gal/A
                                      NS
                                 0.446 lb ai/A
                                 17.1 fl oz/A
                                       7
Retreatment interval of 12 to 21 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Herbs and Spices (except black pepper): Allspice, Angelica, Anise (anise seed), Anise (star), Annatto, (seed), Balm (lemon balm), Basil (fresh and dried), Borage, Bumet, Camomile, Caper buds, Caraway, Caraway (black), Cardamom, Cassia (bark and buds), Catnip, Celery seed, Chervil (dried), Chinese chive, Chive, Cinnamon, Clary, Clove (buds), Coriander (cilantro or Chinese parsley leaves), Coriander seed (cilantro seed), Costmary, Cilantro (leaf and seed), Cumin, Curry leaf, Dill (seed), Dillweed, Fennel [common and Florence (seed)], Fenugreek, Grains of paradise, Horehound, Hyssop, Juniper berry, Lavender, Lemongrass, Lovage (leaf and seed), Mace, Marigold, Mustard (seed), Nasturtium, Nutmeg, Parsley (dried), Pennyroyal, Poppy (seed), Rosemary, Rue, Saffron, Sage, Savory (summer and winter), Sweet bay (bay leaf), Tansy, Tarragon, Thyme, Vanilla, Wintergreen, Woodruff, and Wormwood.
                                 0.13 to 0.222
                             (4.0 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 7 to 10 days.

Luna Sensation
(2.1 lb ai/gal) [264-1090]

                                0.0660 to 0.125
                             (4.0 to 7.6 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 7 to 10 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
                                     Hops
                                0.104 to 0.222
                             (3.2 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 14 days.
NS
Luna Sensation
(2.1 lb ai/gal) [264-1090]

                                0.0495 to 0.125
                             (3.0 to 7.6 fl oz/A)
                                       4
                                     0.446
                                      14
Retreatment interval of 14 days.  Do not replant areas within 30 days of the last application.  Do not graze cover crops within the treated area.  Do not harvest cover crops within the area treated for silage and hay.  Do not apply using aerial application.  Do not apply using low volume applicators.  Do not apply through any type of irrigation system.  Do not apply on hops in California.
Ground, aerial or chemigation
Luna Experience
(1.67 lb ai/gal) [264-1091]

                                0.104 to 0.222
                             (8.0 to 17.0 fl oz/A)
                                      NS
                                     0.446
                                      14
Retreatment interval of 14 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Leafy Vegetables (except Watercress): Amaranth (Leafy amaranth, Chinese spinach, Tampala), Arugula (Roquette), Cardoon, Celery, Celtuce, Chervil, Chinese celery, Chrysanthemum, (Edible-leaved and Garland), Cilantro, Corn salad, Cress (Garden), Cress (Upland, Yellow rocket, Winter cress), Dandelion, Dock (Sorrel), Endive (Escarole), Florence fennel (Sweet anise, Sweet fennel, Finocchio), Lettuce (Head and Leaf), Orach, Parsley, Purslane (Garden and Winter), Radicchio (Red Chicory), Rhubarb, Spinach [including New Zealand and vine (Malabar spinach, Indian spinach)], and Swiss chard.
                                0.104 to 0.222
                             (3.2 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       0

                                       3
Retreatment interval of 7 to 10 days.  For lettuce greenhouse uses the PHI is 3 days.

Luna Sensation
(2.1 lb ai/gal) [264-1090]
Leafy Greens Vegetables (except Watercress): Amaranth (Leafy amaranth, Chinese spinach, Tampala), Arugula (Roquette), Chervil, Chrysanthemum, (Edible-leaved and Garland), Cilantro, Corn salad, Cress (Garden), Cress (Upland, Yellow rocket, Winter cress), Dandelion, Dock (Sorrel), Endive (Escarole), Lettuce (Head and Leaf), Orach, Parsley, Purslane (Garden and Winter), Radicchio (Red Chicory), Rhubarb, and Spinach [including New Zealand and vine (Malabar spinach, Indian spinach)].
                                     0.125
                                 (7.6 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 14 days.
Ground, aerial or chemigation
Luna Sensation
(2.1 lb ai/gal) [264-1090]
Leafy Petiole Vegetables: Cardon, Celery, Chinese celery, Florence fennel (including Sweet anise, Sweet fennel, Finocchio), Rhubarb, Swiss chard.
                               0.0660 to 0.0957
                             (4.0 to 5.8 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 14 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Legume Vegetables (including Soybean): Edible Podded Legume Vegetables: Bean (Phaseolus spp.) (includes Runner Bean, Snap Bean, Wax Bean); Bean (Vigna spp.) (includes Asparagus Bean, Chinese Longbean, Moth Bean, Yardlong Bean); Jackbean; Pea (Pisum spp.) (includes Dwarf Pea, Edible-pod Pea, Snow Pea, Sugar Snap Pea); Pigeon Pea; Soybean (immature seed); Sword Bean.  Succulent Shelled Pea and Bean: Bean (Phaseolus spp.) (includes Lima Bean (green); Broad Bean (succulent); Bean (Vigna spp.) ( except Cowpea, Southpea); Pea (Pisum spp.) (includes English Pea, Garden Pea, Green Pea); Pigeon Pea.  Dried Shelled Pea and Bean.  Dried Cultivars of Bean (Lupinus spp.) (includes Grain Lupin, Sweet Lupin, White Lupin, White Sweet Lupin); (Phaseolus spp.) (includes Field Bean, Kidney Bean, Lime Bean Dry), Navy Bean, Pinto Bean; Tepary Bean; Bean (Vigna spp.) (includes Adzuki Bean, Blackeyed Pea, Catjang, Moth Bean, Mung Bean, Rice Bean, Southern Pea, Urd Bean; except Cowpea & Crowder Pea); Broad Bean (Dry); Chickpea; Guar; Lablab Bean; and Lentil.
                                0.156 to 0.222
                             (4.8 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       0
Do not apply to cultivars that are to be grazed, cut for forage or hay, or used as livestock feed.
Ground, aerial or chemigation
Propulse
(1.67 lb ai/gal) [264-1084]
Dried Beans: Bean (Lupinus spp., includes Grain lupin, Sweet lupin, White lupin, and White sweet lupin), Bean (Phaseolus spp., includes Field bean, Kidney bean, Lima bean, Navy bean, Pinto bean, and Tepary bean), Bean (Vigna spp., includes Adzuki bean, Blackeyed pea, Catjang, Crowder pea, Moth bean, Mung bean, Rice bean, Southern pea, and Urd bean), Broad Bean (dry), Chickpea, Guar, Lablab Bean, and Lentil.
                                0.134 to 0.177
                            (10.3 to 13.6 fl oz/A)
                                      NS
                                     0.446
                                      14
Retreatment interval of 7 to 14 days.  Allow 7 days from the last application until cutting or swathing the crop for harvest. Do not feed hay or threshings or allow livestock to graze in treated areas.
Ground, aerial or chemigation
Luna Experience
(1.67 lb ai/gal) [264-1091]
                Beans (Fresh and Dry, except Succulent Shelled)
                                0.104 to 0.167
                             (8.0 to 12.8 fl oz/A)
                                      NS
                                     0.446
                                      14
Retreatment interval of 10 to 14 days.  Do not allow livestock to graze treated area for 14 days and do not harvest for food or feed within 14 days of application.
Ground, aerial or chemigation
Propulse
(1.67 lb ai/gal) [264-1084]
                                    Soybean
                                     0.133
                                (10.2 fl oz/A)
                                      NS
                                     0.446
                                      21
Retreatment interval of 10 to 14 days.  Do not allow livestock to graze soybean and do not harvest soybean hay for food or feed.

Luna Sensation
(2.1 lb ai/gal) [264-1090]

                                     0.125
                                 (7.6 fl oz/A)
                                      NS
                                     0.446
                                      21
Retreatment interval of 14 days.  Do not allow livestock to graze soybean and do not harvest soybean hay for food or feed.

Luna Experience
(1.67 lb ai/gal) [264-1091]

                                     0.112
                                 (8.6 fl oz/A)
                                      NS
                                     0.446
                                      21
Retreatment interval of 10 to 14 days.  Do not allow livestock to graze soybean and do not harvest soybean hay for food or feed.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Pome Fruits: Apple, Azarole, Crabapple, Loquat, Mayhaw, Medlar, Pear, Pear (Asian), Quince, Quince (Chinese and Japanese), Tejocote, and cultivars, varieties, and/or hybrids of these.
                                0.078 to 0.222
                             (2.4 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 7 to 14 days.

Luna Experience
(1.67 lb ai/gal) [264-1091]

                                0.0652 to 0.130
                             (5.0 to 10.0 fl oz/A)
                                      NS
                                     0.446
                                      75
Retreatment interval of 7 to 14 days.

Luna Sensation
(2.1 lb ai/gal) [264-1090]
  Pome Fruits: Apple, Crabapple, Loquat, Mayhaw, Pear, Oriental Pear, Quince.
                               0.0660 to 0.0957
                             (4.0 to 5.8 fl oz/A)
                                       4
                                     0.446
                                      14
Retreatment interval of 7 to 14 days.

Luna Tranquility
(1.04 lb ai/gal) [264-1085]

                                0.0975 to 0.130
                            (12.0 to 16.0 fl oz/A)
                                      NS
                                     0.446
                                      72
Retreatment interval of 7 to 10 days.
Ground, Drench or Chemigation
Fluopyram 500 SC
(4.16 lb ai/gal) [264-RLGI]
                                  Pome Fruits
                        0.0780 to 0.221 lb ai/100 gal/A
                          2.4 to 6.8 fl oz/100 gal/A
                                      NS
                                 0.446 lb ai/A
                                 13.7 fl oz/A
                                       7
Retreatment interval of 7 to 14 days.

FLU+TFS SC 500
(2.10 lb ai/gal) [264-RLGT]

                       0.0656 to 0.0952 lb ai/100 gal/A
                          4.0 to 5.8 fl oz/100 gal/A
                                       4
                                 0.345 lb ai/A
                                 21.0 fl oz/A
                                      14
Retreatment interval of 7 to 14 days.

FLU+TFS SC 25
(0.104 lb ai/gal) [264-RLGL]

                       0.0650 to 0.0951 lb ai/100 gal/A
                           80 to117 fl oz/100 gal/A
                                       4
                                 0.345 lb ai/A
                                  425 fl oz/A
                                      14
Retreatment interval of 7 to 14 days.

13ESP715 3.3 SC
(3.34 lb ai/gal) [432-RLUG]

                        0.0783 to 0.223 lb ai/100 gal/A
                          3.0 to 8.56 fl oz/100 gal/A
                                      NS
                                 0.446 lb ai/A
                                 17.1 fl oz/A
                                       7
Retreatment interval of 7 to 14 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Potato and Other Root, Tuberous, and Corm Vegetables: Arracacha, Arrowroot, Artichoke (Chinese and Jerusalem), Beet (Garden), Burdock (Edible), Canna (Edible, Queensland arrowroot), Cassava (Bitter & Sweet), Celeriac (Celery root), Chayote (root), Chervil (Turnip-rooted), Chickory, Chufa, Dasheen (Taro), Ginger, Horseradish, Leren, Parsley (Turnip-rooted), Parsnip, Potato, Radish, Oriental radish (Daikon), Rutabaga, Salsify (Black), Salsify (Oyster plant), Salsify (Spanish), Skirret, Sweet potato, Tanier (Cocoyam), Turmeric, Turnip, Yam bean (Jicama, Manoic pea) and Yam (True).
                                 0.13 to 0.222
                             (4.0 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 5 to 7 days.  The grazing of livestock in treated areas within 7 days of application is prohibited.

Luna Sensation
(2.1 lb ai/gal) [264-1090]

                               0.0825 to 0.0957
                             (5.0 to 5.8 fl oz/A)
                                       4
                                     0.446
                                       7
Retreatment interval of 14 days.

Luna Tranquility
(1.04 lb ai/gal) [264-1085]
Potato and Other Root, Tuberous, and Corm Vegetables: Arracacha, Arrowroot, Artichoke (Chinese and Jerusalem), Canna (Edible), Cassava (Bitter & Sweet), Chayote (root), Chufa, Dasheen (Taro), Ginger, Leren, Potato, Sweet Potato, Tanier (Cocoyam), Turmeric, Yam bean, and Yam (True).
                               0.0650 to 0.0910
                             (8.0 to 11.2 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 7 to 14 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
                 Small Berries (caneberries and bushberries):
Blackberry Rubus spp. (including Andean blackberry, Artic blackberry, Bingleberry, Black blackberry, Boysenberry, Brombeere, California blackberry, Chesterberry, Cherokee blackberry, Cheyenne blackberry, Common blackberry, Coryberry, Darrowberry, Dewberry, Dirksen thornless berry, Evergreen blackberry, Himalayaberry, Hullberry, Lavacaberry, Loganberry, Lowberry, Lucretiaberry, Mammoth blackberry, Marionberry, Mora, Mures deronce, Nectarberry, Northern dewberry, Olallieberry, Oregon evergreen berry, Phenomenalberry, Rangeberry, Ravenberry, Rossberry, Shawnee blackberry, Southern dewberry, Tayberry, Youngberry, Zarzamora, and cultivars, varieties, and/or hybrids of these.
Raspberry Rubus spp. (Rubus occidentalis, Rubus strigosus, Rubus idaeus) (including Bababery, Black raspberry, Blackcap, Framboise, Frambueso, Himbeere, Keriberry, Mayberry, Purple raspberry, Red raspberry, Thimblberry, Tulameen, Wild raspberries, Yellow raspberry) and cultivars, varieties, and/or hybrids of these.
Bushberry (including Berry (Aronia), Blueberry (Highbush and Lowbush), Currant (Buffalo), Guava (Chilean), Currant (Black and Red), Barberry (European), Elderberry, Gooseberry, Cranberry (Highbush), Honeysuckle, Huckleberry, Jostaberry, Juneberry, Currant (Native), Salal, Sea buckthorn, and cultivars, varieties, and/or hybrids of these.
                                0.156 to 0.222
                             (4.8 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 7 to 10 days.
Ground, aerial or chemigation
Luna Tranquility
(1.04 lb ai/gal) [264-1085]
                 Small Berries (caneberries and bushberries):
Blackberry Rubus spp. (including Andean blackberry, Artic blackberry, Bingleberry, Black Satin berry, Boysenberry, Brombeere, California blackberry, Chesterberry, Cherokee blackberry, Cheyenne blackberry, Common blackberry, Coryberry, Darrowberry, Dewberry, Dirksen thornless berry, Evergreen blackberry, Himalayaberry, Hullberry, Lavacaberry, Loganberry, Lowberry, Lucretiaberry, Mammoth blackberry, Marionberry, Mora, Mures deronce, Nectarberry, Northern dewberry, Olallieberry, Oregon evergreen berry, Phenomenalberry, Rangeberry, Ravenberry, Rossberry, Shawnee blackberry, Southern dewberry, Tayberry, Youngberry, Zarzamora, and cultivars, varieties, and/or hybrids of these.
Raspberry Rubus spp. (Rubus occidentalis, Rubus strigosus, Rubus idaeus) (including Bababery, Black raspberry, Blackcap, Framboise, Frambueso, Himbeere, Keriberry, Mayberry, Purple raspberry, Red raspberry, Thimblberry, Tulameen, Wild raspberries, Yellow raspberry) and cultivars, varieties, and/or hybrids of these.
Bushberry (including Berry (Aronia), Blueberry (Highbush and Lowbush), Currant (Buffalo), Guava (Chilean), Currant (Black and Red), Barberry (European), Elderberry, Gooseberry, Cranberry (Highbush), Honeysuckle, Huckleberry, Jostaberry, Juneberry, Currant (Native), Salal, Sea buckthorn, and cultivars, varieties, and/or hybrids of these.
                                0.111 to 0.219
                            (13.6 to 27.0 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 7 to 14 days.
Ground or chemigation
Propulse
(1.67 lb ai/gal) [264-1084]
Bushberry subgroup: Aronia berry, Blueberry (Highbush and Lowbush), Chilean Guava, Currant (Black, Buffalo, and Red), Highbush Cranberry, Elderberry, European Barberry, Gooseberry, Edible Honeysuckle, Huckleberry, Jostaberry, Juneberry (Saskatoon berry), Ligonberry, Native Currant, Salal, Sea buckthorn, and cultivars, varieties, and/or hybrids of these.
                                     0.177
                                (13.6 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 7 to 10 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Stone Fruit: Apricot, Apricot (Japanese), Capulin, Cherry (Black, Nanking, Canada, Sweet, Tart), Jujube (Chinese), Nectarine, Peach, Plum, Plum (American, Beach, Canada, Cherry, Chickasaw, Damson, Japanese, Klamath), Prune, Plumcot, Sloe, and cultivars, varieties, and/or hybrids of these.
                                 0.13 to 0.222
                             (4.0 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 5 to 7 days.

Luna Sensation
(2.1 lb ai/gal) [264-1090]
Stone Fruit: Apricot, Cherry (Sweet and Tart), Nectarine, Peach, Plum (including Chickasaw, Damson, Japanese), Plumcot, and Prune (Fresh and Dried).
                                0.0825 to 0.125
                             (5.0 to 7.6 fl oz/A)
                                       4
                                     0.446
                                       1
Retreatment interval of 7 to 14 days.

Luna Experience
(1.67 lb ai/gal) [264-1091]
Stone Fruit: Apricot, Cherry (Sweet, Tart), Nectarine, Peach, Plum (all varieties including Chickasaw, Damson, Japanese, and Stanley), Plumcot, and Prune (fresh and dried).
                                0.0783 to 0.130
                             (6.0 to 10.0 fl oz/A
                                      NS
                                     0.446
                                       0
Retreatment interval of 5 to 7 days.

Luna Tranquility
(1.04 lb ai/gal) [264-1085]
Stone Fruit: Apricot, Nectarine, Peach, Plum (all varieties including Chickasaw, Damson, Japanese, and Stanley), Plumcot, and Prune (fresh and dried).
                                0.0975 to 0.219
                             (12.0 to 27.0 fl oz/A
                                      NS
                                     0.446
                                       2
Retreatment interval of 7 to 14 days.  Do not make more than two applications of a group 9 fungicide within 30 days of harvest.
Ground, Drench or Chemigation
Fluopyram 500 SC
(4.16 lb ai/gal) [264-RLGI]
                                 Stone Fruits
                        0.130 to 0.221 lb ai/100 gal/A
                          4.0 to 6.8 fl oz/100 gal/A
                                      NS
                                 0.446 lb ai/A
                                 13.7 fl oz/A
                                       0
Retreatment interval of 5 to 7 days.

FLU+TFS SC 500
(2.10 lb ai/gal) [264-RLGT]

                        0.0820 to 0.125 lb ai/100 gal/A
                          5.0 to 7.6 fl oz/100 gal/A
                                       4
                                 0.251 lb ai/A
                                 15.3 fl oz/A
                                       1
Retreatment interval of 7 to 14 days.

FLU+TFS SC 25
(0.104 lb ai/gal) [264-RLGL]

                        0.0821 to 0.125 lb ai/100 gal/A
                          101 to 154 fl oz/100 gal/A
                                       4
                                 0.251 lb ai/A
                                  309 fl oz/A
                                       1
Retreatment interval of 7 to 14 days.

13ESP715 3.3 SC
(3.34 lb ai/gal) [432-RLUG]

                        0.157 to 0.223 lb ai/100 gal/A
                          6.0 to 8.56 fl oz/100 gal/A
                                      NS
                                 0.446 lb ai/A
                                  17.1 fl oz/
                                       0
Retreatment interval of 5 to 7 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Strawberry and Other Low-Growing Berries (except Cranberries): Bearberry, Bilberry, Blueberry (Low-bush), Cloudberry, Ligonberry, Muntries, Partridgeberry, and Strawberry.
                                0.104 to 0.222
                             (3.2 to 6.84 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 7 days.
Ground or chemigation
Propulse
(1.67 lb ai/gal) [264-1084]
Low Growing Berry subgroup, except Strawberry and Cranberries: Bearberry, Bilberry, Cloudberry, Muntries, Partridgeberry, and cultivars, varieties, and/or hybrids of these.
                                     0.134
                                (10.3 fl oz/A)
                                      NS
                                     0.446
                                      45
Retreatment interval of 7 to 10 days.
Ground, aerial or chemigation
Luna Sensation
(2.1 lb ai/gal) [264-1090]
Strawberry and Other Low-Growing Berries (except Cranberries): Bearberry, Bilberry, Blueberry (Low-bush), Cloudberry, Ligonberry, Muntries, Partridgeberry, and Strawberry.
                                0.0660 to 0.125
                             (4.0 to 7.6 fl oz/A)
                                      NS
                                     0.446
                                       0
Retreatment interval of 7 to 14 days.

Luna Tranquility
(1.04 lb ai/gal) [264-1085]
Strawberry and Other Low-Growing Berries (except Cranberries): Bearberry, Bilberry, Blueberry (Low-bush), Cloudberry, Ligonberry, Muntries, Partridgeberry, and Strawberry.
                                0.130 to 0.219
                            (16.0 to 27.0 fl oz/A)
                                      NS
                                     0.446
                                       1
Retreatment interval of 7 to 14 days.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
                                  Sugar beet
                                     0.222
                                (6.84 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 5 to 7 days.

Propulse
(1.67 lb ai/gal) [264-1084]

                                     0.177
                                (13.6 fl oz/A)
                                      NS
                                     0.446
                                       7
Retreatment interval of 14 days.

Luna Sensation
(2.1 lb ai/gal) [264-1090]

                                0.0924 to 0.125
                             (5.6 to 7.6 fl oz/A)
                                      NS
                                     0.446
                                      21
Retreatment interval of 10 to 14 days.  Tops or greens from this crop may be utilized for food or feed.
Ground, aerial or chemigation
Luna Privilege
(4.16 lb ai/gal) [264-1078]
Sunflower Subgroup: Calendula, Castor oil plant, Chinese tallowtree, Euphorbia, Evening primrose, Jojoa, Niger seed, Rose hib, Safflower, Stokes aster, Sunflower, Tallowwood, Tea oil plant, Veronia, and cultivars, varieties and/or hybrids of these.
                                     0.222
                                (6.84 fl oz/A)
                                      NS
                                     0.446
                                      14
Retreatment interval of 14 days.
Ground, aerial or chemigation
Luna Experience
(1.67 lb ai/gal) [264-1091]
                                   Sunflower
                                0.117 to 0.167
                             (9.0 to 12.8 fl oz/A
                                      NS
                                     0.446
                                      50
Retreatment interval of 14 days.
Ground, Drench or Chemigation
Fluopyram 500 SC
(4.16 lb ai/gal) [264-RLGI]
                                   Sunflower
                             0.221 lb ai/100 gal/A
                              6.8 fl oz/100 gal/A
                                      NS
                                 0.446 lb ai/A
                                 13.7 fl oz/A
                                      14

13ESP715 3.3 SC
(3.34 lb ai/gal) [432-RLUG]

                             0.223 lb ai/100 gal/A
                             8.56 fl oz/100 gal/A
                                      NS
                                 0.446 lb ai/A
                                  17.1 fl oz/
                                      14

Ground or Chemigation
FLU+TFS SC 500
(2.10 lb ai/gal) [264-RLGT]
                                   Tree Nuts
                        0.0820 to 0.125 lb ai/100 gal/A
                          5.0 to 7.6 fl oz/100 gal/A
                                      NS
                                 0.251 lb ai/A
                                 15.3 fl oz/A
                                      60
Retreatment interval of 7 to 21 days.

FLU+TFS SC 25
(0.104 lb ai/gal) [264-RLGL]

                        0.0821 to 0.125 lb ai/100 gal/A
                          101 to 154 fl oz/100 gal/A
                                      NS
                                 0.251 lb ai/A
                                  309 fl oz/A
                                      60

                                Seed Treatment
Seed treatment with commercial slurry mixture equipment only.
Luna Privilege
(4.16 lb ai/gal) [264-1078]
                                    Peanut
                             0.049725  to 0.124475
                               lb ai/100 lb seed
                              (1.53 to 3.83 fl oz
                                 per 100 lb of
                                 peanut seeds)
                                       1
                             0.446 (from all uses)
                                      NA
Do not use treated seed for food, feed, or oil purposes.
                          Non Agricultural Use Sites
Ground or Chemigation
Fluopyram 500 SC
(4.16 lb ai/gal) [264-RLGI]
Turf Grass: Golf Courses, Sod Farms, Sports Fields, Industrial, Municipal, Commercial, and other Turf Grass areas.
                       0.0013 to 0.0101 lb ai/1000 ft[2]
                        (0.04 to 0.31 fl oz/1000 ft[2])
                           (0.0566 to 0.439 lb ai/A)
                                      NS
                            0.3145 fl oz/1000 ft[2]
                                 13.7 fl oz/A
                                 0.446 lb ai/A
                                      NA
Retreatment interval of 7 to 28 days.

FLU+TFS SC 500
(2.10 lb ai/gal) [264-RLGT]

                     0.000820 to 0.00984 lb ai/1000 ft[2]
                        (0.05 to 0.6 fl oz/1000 ft[2])
                           (0.0557 to 0.429 lb ai/A)

                            0.6267 fl oz/1000 ft[2]
                                 27.3 fl oz/A
                                 0.446 lb ai/A

FLU+TFS SC 25
(0.104 lb ai/gal) [264-RLGL]

                      0.00121 to 0.0102 lb ai/1000 ft[2]
                        (1.5 to 12.6 fl oz/1000 ft[2])
                           (0.0531 to 0.446 lb ai/A)

                             12.6 fl oz/1000 ft[2]
                                  549 fl oz/A
                                 0.446 lb ai/A

FLU+TFS SC 32.5
(0.104 lb ai/gal) [264-RLGA]

                      0.00121 to 0.0102 lb ai/1000 ft[2]
                        (1.5 to 12.6 fl oz/1000 ft[2])
                           (0.0531 to 0.446 lb ai/A)

                             12.6 fl oz/1000 ft[2]
                                  549 fl oz/A
                                 0.446 lb ai/A

13ESP715 3.3 SC
(3.34 lb ai/gal) [432-RLUG]

                       0.0013 to 0.0102 lb ai/1000 ft[2]
                        (0.05 to 0.39 fl oz/1000 ft[2])
                           (0.0566 to 0.444 lb ai/A)

                            0.393 fl oz/1000 ft[2]
                                 17.1 fl oz/A
                                 0.446 lb ai/A

Ground
Fluopyram 500 SC
(4.16 lb ai/gal) [264-RLGI]
                            Residential Turf Grass
                      0.0013 to 0.00912 lb ai/1000 ft[2]
                        (0.04 to 0.28 fl oz/1000 ft[2])
                           (0.0566 to 0.396 lb ai/A)
                                      NS
                            0.2847 fl oz/1000 ft[2]
                                 12.4 fl oz/A
                                 0.403 lb ai/A
                                      NA
Retreatment interval of 7 to 28 days.

FLU+TFS SC 500
(2.10 lb ai/gal) [264-RLGT]

                     0.000820 to 0.00919 lb ai/1000 ft[2]
                        (0.05 to 0.56 fl oz/1000 ft[2])
                           (0.0557 to 0.400 lb ai/A)

                           0.5647 fl ozi/1000 ft[2]
                                 24.6 fl oz/A
                                 0.404 lb ai/A

FLU+TFS SC 25
(0.104 lb ai/gal) [264-RLGL]

                      0.00121 to 0.00926 lb ai/1000 ft[2]
                        (1.5 to 11.4 fl oz/1000 ft[2])
                           (0.0531 to 0.404 lb ai/A)

                             11.4 fl oz/1000 ft[2]
                                497 fl oz/A[2]
                                 0.404 lb ai/A

FLU+TFS SC 32.5
(0.104 lb ai/gal) [264-RLGA]

                      0.00121 to 0.00926 lb ai/1000 ft[2]
                        (1.5 to 11.4 fl oz/1000 ft[2])
                           (0.0531 to 0.404 lb ai/A)

                             11.4 fl oz/1000 ft[2]
                                  497 fl oz/A
                                 0.404 lb ai/A

13ESP715 3.3 SC
(3.34 lb ai/gal) [432-RLUG]

                      0.0013 to 0.009285 lb ai/1000 ft[2]
                       (0.05 to 0.3558 fl oz/1000 ft[2])
                           (0.0566 to 0.404 lb ai/A)

                            0.3558 fl oz/1000 ft[2]
                                 15.5 fl oz/A
                                 0.404 lb ai/A

Ground, Drench or Chemigation
Fluopyram 500 SC
(4.16 lb ai/gal) [264-RLGI]
Ornamentals: in Residential and Commercial Landscapes, Interiorscapes, Field Grown and Container Ornamentals, in Nurseries, and Greenhouses, Lathhouses, Shadehouses, Containers and Other Enclosed Structures.
                             0.221 lb ai/100 gal/A
                              6.8 fl oz/100 gal/A
                                      NS
                                 13.7 fl oz/A
                                 0.446 lb ai/A
                                      NA
Retreatment interval of 7 to 21 days.

FLU+TFS SC 500
(2.10 lb ai/gal) [264-RLGT]

                        0.0164 to 0.131 lb ai/100 gal/A
                          1.0 to 8.0 fl oz/100 gal/A

                                 27.3 fl oz/A
                                 0.446 lb ai/A

Retreatment interval of 7 to 28 days.

FLU+TFS SC 25
(0.104 lb ai/gal) [264-RLGL]

                        0.0163 to 0.130 lb ai/100 gal/A
                           20 to 160 fl oz/100 gal/A

                                 0.445 lb ai/A
                                  548 fl oz/A

Retreatment interval of 7 to 28 days.

13ESP715 3.3 SC
(3.34 lb ai/gal) [432-RLUG]

                             0.223 lb ai/100 gal/A
                             8.56 fl oz/100 gal/A

                                 0.446 lb ai/A
                                 17.1 fl oz/A

Retreatment interval of 7 to 21 days.
Ground or Chemigation
Fluopyram 500 SC
(4.16 lb ai/gal) [264-RLGI]
                                Christmas Trees
                             0.221 lb ai/100 gal/A
                              6.8 fl oz/100 gal/A
                                      NS
                                 13.7 fl oz/A
                                 0.446 lb ai/A
                                      NA
Retreatment interval of 7 to 21 days.

FLU+TFS SC 500
(2.10 lb ai/gal) [264-RLGT]

                             0.220 lb ai/100 gal/A
                             13.4 fl oz/100 gal/A

                                 27.1 fl oz/A
                                 0.445 lb ai/A

FLU+TFS SC 25
(0.104 lb ai/gal) [264-RLGL]

                             0.220 lb ai/100 gal/A
                              271 fl oz/100 gal/A

                                      NS

13ESP715 3.3 SC
(3.34 lb ai/gal) [432-RLUG]

                             0.223 lb ai/100 gal/A
                             8.56 fl oz/100 gal/A

                                 0.446 lb ai/A
                                 17.1 fl oz/A

3.4	Anticipated Exposure Pathways

Humans may be exposed to fluopyram in food and drinking water, since fluopyram may be applied directly to growing crops and application may result in fluopyram reaching surface and ground water sources of drinking water.  In an occupational setting, applicators may be exposed by the dermal and inhalation routes while handling the pesticide prior to application, as well as during application.  There is also a potential for post-application dermal and inhalation exposures for workers re-entering treated fields.  Additionally, there are proposed uses of fluopyram on turf and ornamentals; and therefore, exposure in residential or non-occupational settings is likely, and will result in short-term dermal and inhalation exposures for adult handlers and dermal (for adults and small children) and incidental oral (for small children) exposures from post-application activities.

3.5	Consideration of Environmental Justice

Potential areas of environmental justice concerns, to the extent possible, were considered in this human health risk assessment, in accordance with U.S. Executive Order 12898, "Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations," (http://www.eh.doe.gov/oepa/guidance/justice/eo12898.pdf.  As a part of every pesticide risk assessment, OPP considers a large variety of consumer subgroups according to well-established procedures.  In line with OPP policy, HED estimates risks to population subgroups from pesticide exposures that are based on patterns of that subgroup's food and water consumption, and activities in and around the home that involve pesticide use in a residential setting.  Extensive data on food consumption patterns are compiled by the U.S. Department of Agriculture's National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA) and are used in pesticide risk assessments for all registered food uses of a pesticide.  These data are analyzed and categorized by subgroups based on age and ethnic group.  Additionally, OPP is able to assess dietary exposure to smaller, specialized subgroups and exposure assessments are performed when conditions or circumstances warrant.  Whenever appropriate, non-dietary exposures based on home use of pesticide products and associated risks for adult applicators and for toddlers, youths, and adults entering or playing on treated areas post-application are evaluated.  Further considerations are currently in development as OPP has committed resources and expertise to the development of specialized software and models that consider exposure to bystanders and farm workers as well as lifestyle and traditional dietary patterns among specific subgroups.

4.0	Hazard Characterization and Dose-Response Assessment

The last comprehensive risk assessment was completed in September, 2014 (D414231, B. O'Keefe, 09/22/2014).  The toxicology database is complete and the hazard characterization is unchanged from the last assessment.  This assessment includes summaries of prior hazard characterization.

4.1	Toxicological Effects

Liver effects and decreased body weight were the most common and sensitive findings in the subchronic and chronic oral toxicity studies in rats, mice, and dogs.  Liver effects were characterized by increased liver weight, hepatocellular hypertrophy, hepatocellular vacuolation, increased mitosis and hepatocellular necrosis.  Increased liver tumors were also observed in female rats in the carcinogenicity study.  Liver effects in rodents were seen at lower dose levels (as low as 6 mg/kg) than those in the dogs.  Thyroid effects were found at dose levels similar to those that produced liver effects in rodents; effects consisted of follicular cell hypertrophy, increased thyroid weight and hyperplasia.  Changes in thyroid hormone levels (T3 & T4) and increased thyroid stimulating hormone (TSH) were also seen in rats in a subchronic toxicity study.  In male mice, there was an increased incidence of thyroid adenomas.  In the genotoxicity battery, fluopyram was shown to have no genotoxic potential.

Fluopyram is not a developmental toxicant, nor did it adversely affect reproductive parameters.  No evidence of qualitative or quantitative susceptibility was observed in these studies.