Tuesday,

July 30, 2002 Part V Environmental Protection Agency Fiftieth Report of the TSCA Interagency Testing Committee to the Administrator of the Environmental Protection Agency; Receipt of Report and Request for Comments; Notice I 49530 Federal Register /Vol. 67, No. 146 /Tuesday, July 30. 2002 /Notices ENVIRONMENTAL PROTECTtON AGENCY [OPPT 2002 0026; FRL 7183 71 Fiftieth Report of the TWA Interagency Testing Committee to the Administrator of the Environmental Protection Agency; Receipt of Report and Request for Comments AGENCY: Environmental Protection Agenc: y (EPA).

ACTION: Notice.

SUMMARY: The Toxic Substances Control Act (TSCA) Interagency Testing Committee (ITC) transmitted its 50'1' ITC Report to the Administrator of EPA on May 26, 2002. In ,tht! 50th ITC Report, which is included with this notice, the ITC is rescinding its request in the 46'" ITC Report to EPA for the addition to the TSCA section 8( a) Preliminary Assessment Information Reporting (PAIR) rule of 12 of the 15 Degradation Effects Bioconcentration Information Testing Strategies (DEBITS) chemicals. However. the ITC is asking EPA to add 3 chemicals to the PAIR r& and 3 chemicals to the TSIA section 8ldj Health and Safety Data Reporting ' (HaSDR) rule. The ITC is adding 2 chemicals and removing 36 chemicals from the Priody Testing List. The ITC is soliciting comments 017 its Voluntary Information Submissions Innovative Online Network (VISION) and Voluntary Information Submissions Policy (VISP).

DATES: Comments, identified by docket ID number OPPT 2002 0026, must be received on or before August 29, 2002.

ADDRESSES: (: onmients may be submitted by mail, electronically, or in person. Please follow the detailed instructions for each method as provided in TJnit I. 01tho SUPPLEMENTARY INFORMATION. To ensure? proper receipt by EPA, it is imperative that vou identifv docket control number t1PP'? 2002 0& 6 in the subject line on the first page of your rcsspo~~ se.

FOR FURTHER INFORMATION CONTACT: For general ir~ fonnatim conlnct: Barbara Cunningham, Acting Director, Environmental Assistanc: e Division (7408h/ l), Office of Pollution Prevention and Toxics, Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Wzqhington, DC 20460; telephone numbers: (202) 554 1404; e mail address: TSCA Hotline@ epa, gov. For technical informalion co~~ tact: John D. Walker, Il? Executive Director (7401M), Environmental Protection Agency, 1200 Pennsylvania Ave., NW,, Washington, DC 20460; telephone number: (202) 564 7526; fax: (202) 564 7528; e mail address: ~~ alk~! r. johnd@ cpa. gov.

SUPPLEMENTARY INFORMATION:

I. General Information A. Does lhis Actiiml Apply to Me?

This notice is diroctccl to the public in general. It may, however, be of particular interest to you if you manufacture (defined hy statute to include import) and/ or process TSCA covered chemicals and you may be identified by the North American Industrial Classification System (NAICS) codes 325 and 32411. Because this notice is clirectecl to tlif! general public and other ent ities may also be interested, the Agency has not attempted to describe all the specific entities that may be interested in this action. If you have any questions regarding the applicability of this action to a particular entity, consult the technical person listed under FOR FURTHER INFORMATION CONTACT.

B. How Can I Get Additional Informafion, Including Copies of this Document or Other Related Documents?

1. Ekxtrmicdly. You may obtain electronic copies of this document, and certain other related documents that might be available electronically, from the EPA Internet Home Page at http:// www. epa. gov/. To access this doc: ument, on the Home Page snlec: t "Laws and Regulations," "Regulations and Proposed Rules," and then look up the entry for this document under the "Federal Register Environmental Documents." You can also go directly to the Federal Register listings at http:// www. epa. govlfedrgstr/. You mav also access additional informati& about the ITC and the TSCA testing program through the web site for the Office of Prevention, Pesticides and Toxic Substances (OPPTS) at http:// www. epa. gov/ opptsfrs/ home/ opptsim. htm/, or go directly to the ITC home page at http: llwww. epa. gov/ opptintr/ itc:/. 2. In pylon. The Agency has established an official record for this action under docket control number OPPT 2002 0026. The official record consists of the documents specifically referenced in this action, any public comments received during an applicable comment period, and other inrormation related to this action, including any information claimed as Confidential Business Information (CBI). This official record includes the documents that are physically located in the docket, as well as the documents that are referenced in those documents. The public version of 2 the official record does 110~ include any information claimed as CBI. The public version of the official record. which includes printed, paper versions of any electronic comments submitted during an applic: able c: ommont period, is ava% ble for inspection in the TSCA Nonconfidential Information Center. North East Mall Rrn. B 607, Waterside Mall, 401 M St., SW., Washington, DC. The Center is open from noon to 4 pm,, Monday through Friday, excluding legal holidays. The telephone number for the Cenler is (202) 260 7099.

C. How and to Wlwn Do I Submit cfm7m on ts I'

You may submit c: ommonts through the mail, in person, or electronically. To ensure prop& receipt by EPA, it is imnorativo that vou identifv docket co& o1 number i) PPT 20Oi 0026 in the subject line on the first page or your response. i. By nzail. Submit your comments to: Document Control Of& e 0407Ml.

Office of Pollution Preven` tion a& Toxics (OPPT), Environmenlal Protection Agfmcy, 1200 Pennsylvania Ave., NW., Washmgton, DC 20460. 2. In person or I))/ courier, Deliver your comments to: OPPT Document Control Office (DCO) in EPA East Building Rm. 6428, 1201 Constitution Avo., NW,, Washington, DC. The DC0 is open from a a. m. to 4 p. m., Monday through Friday, excluding legal holidays. The telephone number for the DC0 is (202) 564 8930.

3. El: lectronically. You may submit your c: omments elec: tronic: ally l ty o mail to: oppt. nc: ic@ epa. gov, or mail your computer disk to the address identified above. Do not submit any information elec: tronic: allp that you consider to be CBI. Electronic comments must he submitted as an ASCII file avoiding the use of special characters and any form of encryption. Comments and data will also be accepted OII standard disks in WordPerfecl6.1/ 8.0 or ASCII file formal. All comments in electronic: form must be identified bv docket control d number OPPT 2002 0026. Electronic comments may also he filed online at many Federal Depository Libraries.

D. How Should I I landlr! CBI Informatian that I Want to Submit to tho Agel KY?

Do not submit any information electronically that you consider to be CBI. You may claim information that you submit to EPA in response to this ;iocument as CBI by ma& ing any part or all of that information as CBI. Inl'ormation so marked will not be disclosed except in accordance wilh procedures set forth in 40 CFR part 2. Federal Register / Vol. 67, No. 146 f Tuesday, July 30, 2002 /Notices 49531 In addition to one complete version of the comment that includes any information claimed as CBI, a copy of the comment that does not contain the information claimed as CBI must be submitted for inclusion in the public version of the official record. Information not marked confidential will be included in the public version of the official record without prior notice. If you have any questions about CD1 or the procedures for claiming CBI, please consult the technic: al persorl listed under FOR FURTHER INFORMATION CONTACT.

E. Whut Should I Consider as I Prepme fMy Comm cn ts for EPA?

We invite you to provide your views and comments on the 50'" 1 ITC Report. You may iind the following suggestions helpful for preparing your comments: 1. Explain your views as clearly as possible. 2. Describe any assumptions that you used. 3. Provide copies of any technical information and/ or data you used that support your views. 4. Provide specific examples to illustrate your concerns. 5. Offer alternatives for improvement. 1.3. To ensure proper receipt by EPA, be sure to identify the docket control number assigned ,to this action in the subject line on the first page of your response. You may also provide the name, date, and Eederai Register citation.

II. Background The Toxic Substances Control Act (TSCR) (15 U. S. C. 2601 el sey.) authorizes the Administrator of the EPA to promulgate regulations under TSCA section 4( a) requiring testing of chemicals and chemical groups in order to develop data relevant to determining the risks that such chemicals and chemical groups may present to health or the environment. Section 4( e) of TSCA established the ITC to recommend chemicals and chemic: al groups to the Administrator of the EPA for priority testing consideration. Section 4( e) of TSCA directs the ITC to revise the TSCA section 4( e) Priority ?" esting List at least every G months.

A. The 5O'b ITC Report The 5011' ITC Report was transmitted to EPA's Administrator on May 28, 2002, and is included in this notice. In the SOuz ITC Report, the ITC: 1. Resc: inds its renuast in the 4W ITC Report to EPA l'or t& addition to the PAIR rule of 12 of the 15 DEBITS chemicals. The 12 DEBITS chemic: als are 3 "chloroalkenes," 5 "chlorinated trihalomethyl pyriclines," 1 "trihaloethylidene bisbenzeno" (benzene, 1,1'( 2,2,2 ~ic: llloroethylidcno) his, CAS No. 2Q71 Z 4); and 3 "trichlorophenyldihyclropyrazols" (benzamide. 3 amino N 14.5 dihvdro+ oxo 1( 2,4, fil~ ichlorophEnyl) 1~ pyrazol+ yl], CAS No. 40567 18 8); 3H pyrazol 3 one, 5((%& no 2 chlorophenyl) amino) 2,4 dihydro 2 (2,4,& trichlorophenyl), CAS No. 53411 33 Q; and bcnzamide, N( 4,5 dihydro 5 oxo I( 2,4 f& trichlorophenyl) 1H pyrazol 3 yl)+ nitro, CAS No. 63134 25 8. The ITC is not rescinding its request in the 4iW ITC Report to add benzanamine, 3 chloro 2,& dinitro N, N dipropyl+( trifluoromethyl], US No. 29091 20 l: SH pyrazol 3 one, 5(( 2 chloro 5 nitrophenyl) amino) 2,4 dihydro 2[ 2,4,& trichlorophenyl), GAS No. 30707 68 7; and phenol, 4,4'[ 2,2,2 lrshloro l (tri~ uorome~~ yl) c~ i~ lirleneJl~ is, CAS No. 1478 61 1 to the PAIR rule. 2. Adds 3 chemicals to the PAIR rule: 1 DEBITS chemical Istannane. dimothylbis[( 1 ox& eoder: yl)~~ xy], CAS No. 68928 76 7) from the 491" Report; 1 DEBITS chemical (benzene, 1,3,5 tribromo 2( 2 propenyloxy), CAS No. 3278 89 5) and 1 triazone, 1,3 diphenyl, CAS No. 13635 c from the 5otll ITC Report. 3. Adds stannane, dimr? Lhylbis[( 1 ~~ xoncocloc: yl) ox~~], CRS No. 68928 xi 7; benzene? 1,3,5 tribronio 2( 2" proponyfoxy), GAS No. 3278 89 5; and 1 triazene, 1,3 cliphonyl, CAS No. 136 35 6 to .the TSCA section 8( d) HaSDR rule. 4. Solicits comments on its VISION and VISP.

B. Status of the Priority Testing List The ITC is adding benzene, 1,3,5 tril) rorno 2( 2 prolJen~ floxs) (CAS No. 3278 89 5) and l triaztme, 1,3 diphenyl (CAS No. 136 35 6) to the Priolzily Teslillg List. The ITC is removing acetone, 9 "alkylphenols" and "aIkylpheuo1 ethoxylatos" added in the 37'" ITC Report, 7 "nonylphonol ethoxylates" added in the 39th ITC Repoil, 4 "alkylphenols" and "alkvlnhenol ethoxvlates" added in the 415' iTk Report, 3 a'EBITS chemicals added in the 46th ITC Report, 3 DEBITS chemicals (3 "c: l~ loroalbnes") added in the 471" ITC Report, and 9 DEBITS chemicals added in the 48'1' ITC Report ii om the Priority T~` sfing List. The current TSCA 4( e) P& o& y Testing List as of May 2002 can he found in Table 1 of the 50th ITC Report which is included in this notice. List of Subjects Environmental protection, Chemicals, Hazardous substances.

Fiftieth Report of the TSCA Interagency Testing Commiltee to the Administrator, U. S. Environmental Proteclion Agency Summary I. Hackf! rourrd 11. TSCi Section 8 Rqborting A. TSCA Section 8 Reuortinn Rules B. ITC's Usu of TSCA ?? ecti& 8 and Other E. Requests to eromulgate TSCL Section s( a) PAIR and Section 8( d) HaSDR Rules III. UC's Activities Durint! this Ker> ortinc Period (November 2& l to A{ ril ZO&) A. VISION B. L JmrI'S IV. Revisions to the TSCA Section 4( e) Priority Testing List A. Chemicals Added to the %or@ Tes! ing Lisl propenyloxv). 2. 1 Triazorle. 1. Z diuhenvl. B. Chemicals Rkm& d I?& the Priorit~~ `I'eslirzg l; isl 1. Acnto11e.

2. Twcznty alkylphonols and alkylPhtmo1 ethoxvtates. 3. Throo &BITS chemicals from the 4W ITC Report. 4. Three DEBITS chemicals from the 47b 1'1%

SUMMABY III this 50'" ITC Reporrt. thho ITC is rescindirlg its request to tht) EPA to add 12 Degradation Blfects Biocorlcentration Information Tesling Strategies (LWUTS] chemicals to the TSCA saction 8ial l'relimin~ y Assessment Inforrx& n Reporting (PAIR) rule (3 DEBITS c: hemicels frou~ tho 47t" 1 ITC Report and 9 DEBITS chemicals from the 48'" il'C Report]. However, the I'I'C is asking the &PA to add 6 c: hemic: als to the PAIR rule. 3 DEBITS chemicals (a chloro 2, fj dinitro NtN di~ roovl 4 ltrifluoromethvlf bollzc311Eamin~. S i pj& ol? one: 5(( 2~ cl& o S nitroplie~~ yl) amino) 2,4 dihydro 2( z, 4,6 trichlorr~ pher, nvl); and phanot, 4,4'[ 2,2,2 trifluoro 1( tr~ fluoromethgl) otl~~~ lidone] bis 1, from tha 46" ' ITC Report, 1 DEBITS chemical (stsnnane, dimt! thylbis(( l oxonc? odecyl) oxy]

), hm the 4w lx Reporl, 1 LXMTS 3 49532 Federal Register/ Vol. 67, No. 146/ Tuesday, July 30, 2002 /Notices chemical (benzene, 1,3,5 tribromo Z( 2 pq~ enyloxy)). and from the 50" ITC Report, l triazene, 1,3& phtmyl. The ITC is also asking the EPA to add starmane, climetl~ ylbis l( 1 oxoaeodecyl) ox~]: benzene, 1. X5 trihromo 2( 2propenyloxy); and l triazene, 1,3 diphrmyl to the TSCA section 8( d) Health and Safety Data Keporting (HaSDK) rule. The ITC is adding benzene, `1,3,5 Mbrumo 2( 2 prope1~ ylox~) and 1 triazene, 1.3 diphm$ to the Priority Testing List. The ITC is rt? rnaving acetone, 9 alkylphenuls and alkylphenol trthoxylates from the :< F ITC Report, 7 noiiylphenol ethoxylates li~ m the :%+ ITC Report, 4 alkylphenols and alkylphenol ethoxylates from the 41"`: IX Report, 3 DEBITS chemicals from the 46P ITC Report, 3 DEBITS chelnicals from the 47th lTC Kaport, and 9 DEBITS chemicals horn the 48" ' ITC Report and horn the Sriosity Testing List. The ITC is solicithi:: comments on its Voluntary information Submissions Innovative Online Network (VlSION) and Voluntary Information Submissions Policy (VW). The revised TSCA section 4( e) Priority `I'csliq List follows as `Table 1 of this appe11dix.

TABLE I . THE TSCA SECTION 4(~) PRIORW TESTING LIST (MAY 2002)

I

Report Date 28 May 1991 31 January 1993 32 May 1993 35 November 1994 37 November 1995 39 November 1996 41 November 1997 42 May 1998 42 May 1998 46 May 2000 47 November 2000 47 November 2000 48 May 2001 48 May 2001 48 May 2001 49 November 2001 50 May 2002 50 May 2002 Chemical name/ Group Action Chemicals with Low Confidence Reference Dose (RfD) Thiophenol Designated 13 Chemicals with insufficient dennat absorption rate data Designated 16 Chemicals with insufficient dermal absorption rate data Designated 4 Chemicals with insufficient dermal absorption rate data Designated 6 Alkylphenols and alkylphenol ethoxylates Recommended 1 Nonylphenol ethoxytate Recommended 3 Alkylphenols and alkylphenol ethoxylates Recommended 3 Amino& mercapto 1,2,4 triazole Recommended Glycoluril Recommended 8 Nonylphenol poiyethoxylate degradation products Recommended 37 lndium compounds Recommended Pentachlorothiophenol Recommended Phenol, 4,4'[ 2,2,2 trifluoro l( trifluoromethyl) ethylidenejbis Recommended 3 Chloro 2,6 dinitro N, N dipropyl l( trifluoromethyi) benzeneamine Recommended 3H PyrazolS one, 5[( 2 chloro 5 nitrophenyl) amino] 2,4 dihydro 2 Recommended (2,4,6 trichlorophenyl)

Stannane, dimethylbis[( l oxoneodecyl) oxyJ Recommended Benzene, 1,3.5 tribromo 2( Z propenyloxy) Recommended I Triazene, 1,3 diphenyl Recommended 1. Background httl~: ll\ Yww. cpa. gov/ f~ dr~ s~ after publication chemical groups (about 1,400 chemicals) for The IX was established by section 410) of TSCA "to make recomrnend~~ tiorls to the Administrator respecting the chemical substauces and mixtures to which the Administrator should give priority consideration for the promulgation of a rule for testing under section 4( a).... Al least every six months . . . . lhe Commitlee shall make such revisions Lo the Primity 'l? stil7g List as it determines to be nocessaq and transmit them to the Administrator together with the Committee's rf? asons for the revisions" (Public Law 94 469, 90 Stat. 2003 el seg., 15 IJ. S. C. 2601 et seq.). Since its creation in 1976, the ITC has submitted 49 semi annual (May and November) repurts to the EPA Adiiiiniskator tralsmilliq the Priorify Test& List and its ravisions. IX Reports arf? available from the ITC's web site (http:// www. epa. gov/ opptintr/ itc) within a few daps of submissiorr to the Administrutor and born in the Federal Register. `limo ITC meets monthly and produces its revisions to the Prior@ Testing List with administrative and technical support. frum the IX staff I?%: members and their I!. S. Government The 5OtrL UC Report marks a si@ ficant milnstone for the i'K. Since its first meeting organizations, and contract support provided on February 5, 1977, the i'I'C has convened 425 meetings, screened thoousands of by EPA. I'l'C members and staff are listed at chemicals, and reviewed more than 2,500 the end of this Report.

organic, ogano metallic, and inorganic: chemicals to identify those with suspicions of toxicity, environmental release, and consumer or occupational exposures, but few, if a& y data (Ref. 14). 111 it's 50 tCepuiZs, the IX has added to the PrjorilIT ?` es!. qq Lisf and recommended testing or information reporting for 8 1 individnal chemicals and 80 priority consideration by the EPA Administrator. in response. the EPA has published 2~ 0 Federal Kegister notices and reviewed hnndreds of test prolocols and ddla As of l'J92. testing was ongoing. proposed, under consideration. required or voluntarily submissions end the U. S. chemical industry oonducted for 85% of the chemicals and has developed over 1, CJOO tests and submitted clm3tical groups reconm~ snded by the ITC, (Ref. 24). iMany of the data developed as a result of ITC's recommendations have been more than 75.000 unpnbiisliad health and incorporated into Material Safety Data salety studies to the WA.

Sheets, used by U. S. Government and industry oga& atioris lo develop hazard assessments and included in the Organization for Economic Cooperation and Development (OECD) Screening Information Data Sal (SlIX] dossiers (e. g., 1001ti~ of the __ Federal Register /Vol. 67, No. 146 /Tuesday, July 30, ZOO2 /Notices 49533 c: hemicals in phase I of the OECD SIDS prngram were reviewed by the IX Prior to preparation of SIDS dossiers), [Ref. 14). Wall known oxamplss of chemicals for which data have been developed as a result of IX mcornmendaliolIs include alkyl phthaiates, chlorinated paraffins and hc! xat: hlorobu~ adic~ ne (I& f, l), acrvlamido, arvl phosphates, mathylene cl& ids and t.& chloroethane (Ref. 2), chlorinated benzenes (Refs. 1 and 3), benzidine, o dianisidinn and o toluidiritr based dyes (Ref. 4). I~ henylencdi~~~ hles (Ref. 5J, alkyl tins and iluoroalkancs (Ref. 8). octylphenol (Ref. 7), bisphenol A (Ref. U), ~e~ rabromobisphanol A (Ref. Q), methyl tertiary butyl other or MTBE (Kef. lo), and brominated flame retardants, including brominatnd diphonyl others (Ref. 11).

II. TSCA Section 8 Reporting A. TSCA Section 8 Reporting Rules Following rocuipt of the ITC's Report (and the revised i+ iorit~ Testing List) by ,thc WA Administrator, the EPA's Office of Pollution Prevention and Toxics (OPPT) promulgates TSCA section 6( a] PAIK and `L'SCA section S( d) HaSDK rules for chemicals added to the Priority Testing List. The PAIR rule requires producers and importers of Chemical Abstract Service (CAS) 1rumberec1 chemiculs added to Ihe IJriority `I'cslirzg List to submit production and exposure reports under TSCA section 8( a). The HaSDR rulr: requires ~~ r~ ducers, importers, and processors 0 all chamicals (including those with no CAS numbers) added to the Priority Testing List to submit unpublished health and safety studios under TSCX section R( d) that must be in c; ompli~ anc; ct with the revised HaSDR rule (83 FR 15765, April 1, lQQfJ) (FRL 5750 4) codified at 40 CFR part 718. All submissions must be received by the EPA within QO ds?; s of the reporting r& s Federal Register publication date. The reporting rules are automatically promulgated by OPPT unless otherwise requested by the ITC. Under the ITC's VISION and VISP, promulgation of HaSDK rules for IIIOS~ chemicals that are added WI the l3kiL. y Testing List has bwm delayad to allow voluntary submission of studies of specific: interest (see section 1I. C. for further details on VlSlON and VlSP).

The ITC reviews the TSCA section 8( a) PAIR rule reports, TSCA section 8( d) HaSDR rule studies and other information that beccJInt? S availabln after the I'l'C adds cl1emicals lo the lJric& y l'esljng Lis!. Other information includes `TSCA section 4( a) and 4( d) studios; TSCA section U( c) submissions; TSCA section 8( e) "substantial risk" noticus: "For Your Information" (FYl) submissions; lTC voluntary subrnlssions, unpublished clata submitted to and from U. S. Covornment organizations represontcct on the ITC; published papors, as well as use. exposure? effects, and persistence data that arc voluntarily submitted to the ITC by manufacturers, Importers, processors, and users of chemicals recommended by the KC. The ITC reviews this information and doterminus if data needs should be ruvised, if chemicals shonld he rumovad from the Priority Testing Lisf , or if recommendations shnulcl bt! changed io designations.

C. Promoting More Effi&? nt I,& .of Irf~ formuliorr Suhniss~ o~~ Resources 1'0 promote more efficient use of information submission resources, the ITC developed the VlSP and VlSION. The VISP provides examples of data needed by IX member U. S. Government c) rganizations, examples of studies that should not be submitted, the milestones for submitting information, guidelines for using the TSCA Electronic HaSIlR Form and instructions for oladronically submitting full studies. The VW is && bed in the WC's 4l"` Report (63 FR 27058, April Q, lQQ8) (FRL 5773 5) and is accessible through the world wide web (httP;/ l~~~~~ w.~ l) a. govlopptintr/ itc/ visI~. htm ). To facilitate the implementation of the VISP, the lTC developed the WSION. The VISION is described in the lTc's 42"" ' ITC Report (63 FR 42554, August 7, lYQ8J (ML 57Q7 8) and is also accessible through the world wide web (httIJ://~~~ w. c? pa. gov/ oIJp~ it~ tr/ ifitc/ visionhtm). The WSION imcludt~ s links to the `TSCA Electronic HaSDR Form (http:// ~ww. epa. govlopptintr/. er/ hasd. htni) including revised section 3.2 of the TSCA Bloctronic HnSDR Form ta provide mom use and exposure information (for details see the 4W ITC Report; 85 PR 75552, Docfxnber 1, 2000) @x& 6594 7). The ITC requests that chemical producers, importers, processors, and users provide information eler.* ronically via VlSlON on chemicals for which the KC is soliciting voluntary inform& m. If the ITC doos not receive voluntary information submissions to meet its datia n~ cls according to the procednros in VISP, tho ITC may than ask the EPA to add those c: hamicals to a TSCA section U( d) HaSLX rule to determine iftllere are unpublished data to ruest those nesds (sot: section IIl. A. that requests commants on thtt need to continue VISION and VlSP).

19. Coordinati~ lg hformntion Rrquests To avoid duplicate reporting, the I'I'C carof~ dilllp coordinates its inforrnatiou solicitations and reporting ruyuirements with other national and international lusling programs, (e. g., the National Toxicology Program, the OECD SIDS program aud the EPA's High Production Volume (WV) Chaliongo program). The IX is currcmtiy focusing its efforts on persistent non HIT chemicals that have bioconcentration and exposure potential, but few, if any. publicly available ocologic: al or health effoc: ts data The ITC is working with the EPA Persistent Bioaccumulativo Toxics (PHT), Endocrine Disruption, and perfluoroctylsulfooaate chemicals workgroups to identify potontiallp toxic chemicals with few data to complement the oBjectives of those programs.

B. Rquluesfs to Promulpiu TSCA Section X( a) PAIR und Section U{ cI) HuSDB B& s The ITC asked the EPA to add 3 chloroalkenes to tlm `ISCA section 8( a) PAIR rule in its 4WL WC I& port (88 IX 51278, October 5, 2001) (FRL 6786 7). 111 addition, the ITC asked the EPA to add 5 chlorinated trihalomethyl pyridincts, 2 trihaloothylidone bisbcnzenes, 4 trichloropI~ enyl~~ iihydroI~ yrazoIs, and 3 chloro X, 8 dinitro N, N dipropyl 4 (trifluorornethyl) benzeaeaminc? Ilinf~ to the `I'SCA section 8( a) PAlK rule in its 48'11 1'1% Report (68 1% 51276, October 5. 2001). At this time. the WC is rescinding its requosf to add the 3 chloroalkenos; 5 chlorinated trihalomethyl pyridines; 1 of the trihaloo~ hylidone bisbenzones (benzone, 1,1' (2,2,2 trichloroetl~~ lidene) bis, CAS No. 2971 22 4); and 3 of the trichlorophenyldihydropyrazols (bonzamida, 3 amiilo N/ 4,8 dil~ ydro B oxo l (2,4, ti

trichlorophenyl) lH pyrazol 3 yl, CM No. 40587 18 8. 3H pyrazol 3 one, 5(( 5 amino 2 c: hloroyhenyl) anlino) 2,4~~ it~ y~. o 2[ 2,4. ti 1richlorophenyl), CAS No. 53411 33 y. and benzamide, N.:( 4,8 rli~~~ drLI 5 oxo l( 2,4,8 trichlorophonyl) lH pyrazol:% yl)+ nitro. CAS No. 03134 25 8) to the TSCA section 8( a) PAIR rule, either because no production or importation data were submitted to the EPA in response to tho 1998 Inventory Update Rule @JR) or because the predicted bioc: oncentration factors (BCPs) wore judged to be too low to warrant priority consideration at this time. The WC is not rescinding its request to add 3 chloro 2, fj dinito N, N dipropyl 4 (trifluororm~! thyl) beIr~ ene~ Ilinc (CAS No. 2QOQl 20 l), 3H pyrazol 3 one, 5((& chloro 5 nitrophenyl) amino) 2,4 dihydro Z( 2.4,8 trichlorophenyl) (CM No. 30707 8% 71, and phenol, 4,4'[ 2,2,2 trifluoro 1 (trifluoromctthyl) ethglidanej~~ is (CAS No. 1478 81 l) to the TSCA section 8( a) PAIR rule. At this time, the IX is also asking the EPA to add starmane, dimethylbis[( l oxont: odecyl] oxvl (CAS No. ti892H 76 71, benzene, 1,3,5 thbrolno 2( 2 propenyioxy) (CAS No. 3278 89 5) and I Mazene, 1,3 diphenyl (CAS N0.138 X 6) to the TSCA section B( a) PAIR rule. Stannane. dimethylbisl( 2 oxo~~ eoclec~~ l) oxy I and benzene, 1,3,5 trihromo 2( 2 propenyloxy) are being added to the TSCA section 8( a) PAIR rule, because they are cmtimated to persist and have predicted I XX's of 8,650 and 4,019. respuclively, few toxicity data and a noocl for additional use and exposure data, hepond that provided by the manufacturers. I Triazene, 1,3 diphenyl is being added to the TSCA section 8( a) PNK rule, becanse it is a prodictod carcinogen based on its metabolism and bocauso the ITC needs occupational exposure data. At this time, the ITC is also asking the EPA lo add stannunc, climctthylbis[( l oxoneodeoyl) oxyl, benzene, 1,3,% ribromo 2( 2 propenyloxy) and 1 lriazene, 1,3 diphenyl to the TSCA section 8( d) HaSDR rule. Stannano, dimothylbis[( l oxont: odecyl) oxyj is being adclad to the TSCA section 8( d) HaSDR rule, I~ c; ause the ITC needs to know if there are other toxicit) data in addition to that described in section lV. A. 2. and 3. of the 49'31 Report (87 FR 10298, March 8.2002) (FRL 8820 8). The ITC needs ecological effects and more health effects data; only studies where starmane, dil~ lethylbisl( l oxor~ ao~ le~ yl) r) xyj is 290% of Ihe test substance by weight should be submitted. Benzene, 1,3,5 tribromo 2( 2 propenyloxy) is being added to the TSCA section 8( d) HaSDR rule, because the I'IC needs to know 49534 Federal Register / Vol. 67, No. 146 /Tuesday, July 30, 2002 /Notices if there are other toxicity data in addition to that described in section iV. A. l. iii. of this Report. The ITC needs ecological ef!& cls and more health effects data; only studies whore benzene, 1,3,5 tribromo 2( z propenyloxp) is ZW% of the test snbstaace by weight should be snhmitted. 1 Triaxene, 1,3 diphonyl is being added to the TSCA section 6( d) HaSDK rule, because the ITC needs pllarrrlacokirletics, genotoxicity, subchronic and chronic toxioity, reproductive, and developmental toxicity data. Only studies where di~ oanliI~~~ hc, llzerlg is XXJ% ol the lest substance by weight should be submitted.

III. WC's Activities During this Reporting Period (November 2001 to April ~002)

A. V1SK h'

The KC is the only organization for which the EPA cm promuIgate dire13 TSCA suction 8( d) HnSDR final rules. As such, when the EPA cm~ venod public meetings to discuss mvisioris to the TSCA section 8( d) HaSDR rule [63 F'K 15765, April 1, 1998) (PRL 5750 4), the KC was invited to provide and respond to comments on this rule. One of the most consistent comments by the chemical industiy was that the 1TC should offer more opportunities to provide voluntary information submissions [to avoid the mandatory requirements of submitting inform& n in response to a TSCA sec: tion 8( d) HaSDR rule). In rasponso to these chemical industry requests, the ITC developed VISI'. VISION, and the TSCR Electronic HaWR Form. ar~ l is currentl?; evaluating their effecliveness. `Thu EC developed VISP , VISKIN, and the TSCA Electronic HaSDR Form as tools to provide a more cost effective method for chumioal producers, importers, processors, and users of ARC rt? c~ omulanded chemicals to provide voluntary information. With the exception of 3 trade organizations, the Alkylphenols (L Ethoxylates Research Council (APEX), the Color Pigment Manufacturers Association (CPMA), and lhe Ecological ancl `f'oxicologicsl Association of Organic: Dye Manufacturers (ETAD), and 4 manufacturers. 3M Spoc: ialty Materials, Ciba Speciality Chemicals, B. I. du Pont de Nemours and Company, and Rohm and Haas Compall> f, these tools have not been used by cheinlcal producers. importers, processors, and users of ITC recommended chemicals. The ITC has received voluntacy information submissions on ~15% of the approximately 500 chemicals for which the lTC has solicited voluntary information since implementing the VW and VlSION, in effect delapiug the l'l'c's ability to obtain the information it needs to make doc: isions and meet U. S. Government data needs. The ITC recognizes that there are increasing demands on the c: homic: al industry to provide information in response to voluntary initiatives, e. g,. the OECD SIDS program, EPA HPV Challenge program and Voluntary Children's Chemical Evaluation Program (VCCEP). The ITC supports and coordir& es its voluntary information requests with these programs. Howover, as a statlltorp mandatat11 organization charged with screening and identifying potentially hazardous chemicals, the ITC also recogdizes that the chemical industry has the responsibility under TSCA and under the principles of Respomible Care@ and Chemical Right to Know. to promptly and voluntarily provide information on the ITC's rt: commc: nded chemicals to be used in subsequent hazard, exposure, and risk assessments by the U. S. Government organizations represented on the XC. The IX is considering whether to continue he use of the VISP, VISWN, and the `1'SCA JJlectronic HaSDR Form for chemicals added to the Priorily li; stin, v Lid, as the lack of use of these tools has resulted in substantial delays in obtaining information thal could be used to moat the LX's data needs, The ITC requests comments on procedures that could be implemented to make these existing tools or other procedures for submitting voluntary information more effective. Comments in a word processing file attached to an c mail to walkar. johrIdQepa. gov are prelerred, but the ITC will also accept comments submitted lo Dr. Tohn LX Walker at the address listed at the end of this Report by September 30, 2002.

s. DEBITS In its 4+ thrwgh 4@ ITC Reports3 the KC desoribnd its strategies to scrt~ l and twaluxte chemicals with persistence and bioconce~ ltratioll potential. These activities are referred to as DEBlTS. LXWTS provides a means to prioritize chemicals ii> r information reporting and testing based on degradation and bioconc~ ntration potential and availability of efff; cts data. Prior to this reporting period the ITC made information reporting or testing deferral decisions on 206 D) IBI'l'S chemicals. During this reporting period, the lTC completed its review of the remaining 252 DEBITS chemicals, including the 9 chemicals discussed in this section: 1. Benzene, 1,:% 5 trihromo 2( 2 proponyloxy) (CAS No. 3278 89 53, 2. 2,~ r) imethylquinataidone (CAS No. YUO 26 71, 3. 1,2 Ethanodiyl tetrakis [2 chloro I methylethyl) phosphate (CAS No. 34621 SY 31, 4 Oxirane 2 2' 2"

.5. Fcresol, 2.6 di terl butyl alpha (dimathylamino) (CAS No. 88 27 7), 6. Spiro isobonzoflnan l( 3H), 9'` i) H xanthen+ one, 8'. 8' llis( t? thylaillino) 2', 7' dimethyl (CAS No. 41382 37 O), 7. lH indole 2 carboxaldehyde, 2,3 dihydro 2 hydroxy 1,3,% trimethgl( 4 rnethoxyphcnyl) methylhydr~ zone (CAS No. 61241 W R), 8. Phsnoxazin 5 iurn, 3,7 bis( diothylarnirlo), (T 4) tetrachlorozinca~ e( 2~) (21) (CAS No. 63~~. 47 Y), and 9. Oxirane, 2[ 2( 4 chloro~~ he1lyl) otl~ ylj 2 (l, l cii~~ letliyletl~~~ i) (CAS No. 80443 63 6). The lTC is adding benzene, 1,3,5 trihromo 2 12 propenyloxy) to the Prjority Test& 2; ist as discussed in section IV. A. 1. The ITC deferred making a testing recommendation for 2, s flimc~ rt~ ylquinacridone beoause its absorption potential into mammalian tissues is expnbed to he low based on absorption data for the structurally related EPA HPV Challenge chemical, 5,12 dihydroqnino( 2,3 b) acridine 7,14 dione (CAS No. 1047 16 l). 1,2 Bthancdi~ l tetrakis (Z chloro l methylethyl) phosphate was previously removed from the Prioritv Tftstining List in the 1Tc's 36l" ITC Report (GO FR 42982, August 17,199! 5) (FlL. 4965 6). Oxirane, 2,2', 2"( mc? thylidyI~ etris (phonyleneoxymeth) e~ ie)) lris was defelrsd for testing because its predicted hydrolysis half life was 3 days. The 1TC deferred rrraking testing recommendations for p cresol, 2,6 di tert buryl alpila( dimethylainiilo); Spiro isobeilzof~ an l( 3H). 9'` 3H xanthen+ one. 3', 6' bis( ethylamino) 2', 7' dimethyl: lH indole 2 carhoxaldahyde. 2,~ dihyd. ro 2 hydroxy l, 3,3 trimeth~~ l( 4 methoxyphenyl) met~ lylhydrazone: and phenoxazin 5iam, :~, 7 his( diethylamino). (T 4) lotrachlorozi~ icala( Z) (2~ 1) because of their low exposure potential. Oxirane, a 12( 4 chlorophc! nyl) ethyl] 2( l, l diInetll~/ lethyl) was deferred for testing because it is likelv to be tested under one of the voluntary H@ V chemical testing Programs. The remaining 243 DEBITS chemicals deferred for testing include 7 DEBrlYS chemicals with predicted BCFs <1,000 (see Table 2 of this appendix), 28 EPA HPV Challenge program DEBl'l'S chemicals (see `Table 3, of this appendix), and 208 non HIJV DlXBl'I'S chemic: als with predic: ted l3CFs of 3 13 [see Table 4 of this appendix).

TABLE ~ SEVEN DEBITS CHEMICALS WITH PREDICTED BCFs cl ,000 1 CAS No. Chemical name Structural class 1 BCF 827 94 l 90 93 7 2,6 Dibromo Cnitrobenzenamine Bie[ 4( Dimethylamino) phenyl] methanone 2,6 Dibromoanilines 64 4,4' Substituted benzophenones 467 I 6408 72 6 I  9, lO Anthracenedione, 1,4 diamino 2,3 diphenoxy 1 Diaminoanthraquinone I 585 ~~~~ I CAS No. Federal Register / Vol. 67, No. 146 /Tuestlay, July 30, 2002 /Notices TABLE ~. SEVEN DEBITS CHEMICALS WITH PREDICTED BCFs <I ,OOO Continued Chemical name Structural class 49535 ( BCF 19014 53 O 9,10 Anthracenedione, l amino 2( 4(( hexahydro 2 oxo IH azepin I yl) methyl) phenoxy) 4 hydroxy Hydroxyamino anthraquinones 596 03 Z Spiro isobenzofuran 1( 3H), 9' 9Hxanthen 3 one, 4,5' Spiro[ isobenzofuran 1( 3H), Q'[ 9H] xanthen] 3 one. s dibromo 3;, 6' dihydroxy, disodium salt 1709 I 2280 49 I N Phenyl N( trichloromethylsulfenyl) benzene Slll

fonamide /59a 1 20941 65 5 Tetrakis( diethyicarbamodithioato S, S') tellurium I I G 7 TABLE 3. TWENTY EIGHT EPA HPV CHALLENGE PROGRAM DEBITS CHEMICALS CAS No. Chemical name Structural Class[( 2 Hydroxy l naphthalenyl) azo] benzenesulfonate salts 7023 61 Z 2 Naphthalenecarboxylic acid, 4(( 5 chloro 4 methyI 2 suifophenyl) azo) 3 hydroxy., calcium salt (1: l)

7585 41 3 2 Naphthaienecarboxylic acid, 4(( 5 chloro 4 methyI 2 sulfophenyl) azo) 3 hydroxy~, barium salt (1: l)

Structural Class[[ 4[( Phenyl) ato] phenyl] azo] benzenesulfonic acid salts 68555 86 2 Benzenesulfonic acid, 4(( 5 methoxy 4(( 4 methoxyphenyl) azo) 2 methylphenyl) azo), sodium salt Structural Class 4,4' bis( Triazinylamino) stilbene 2,2' disulfonic acid salts 5182 81 9 2,2' Stilbenedisulfonic acid, 4,~ bis(( rl anilino 6 morpholino s triazin 2 yi) amino), disodium salt 67786 25 8 Benzenesulfonic acid, 22'.( 1 ,2 ethenediyl) bis( 5(( 4( bis( Z hydroxypropyl) amino) 6(( 4 suIfophenyl) amino) 1,3,5 triazin Byl) amino), tetrasodium salt Structural Class  4 Amino 4' nitroazobenzenes 3618 72 2 Acetamide, ( 5( bis( 2( acetyloxy) ethyl) amino) 2(( 2 bromo~, 6 dinitrophenyf) azo) 4~ methoxyphenyl)

Structural Class Halogenated cycloalkenes 77 47 4 l, 3 Cyclopentadiene, 1,2,3,4,5,5Hexachloro

3734 18 3 4,7 Methanaindene, 4,5,6,7,8,8 hexachloro delta( sup I$) tetrahydro (chlordene)

62111 47 I Heptachlorocyclopentene Structural Class Halogenated propanes 1070 78 6 1 ,I ,I ,3 Tetrachioropropane 16714 68 4 1 ,I ,2,2,3 Pentachloropropane Structural Class Hexachforobicycto[ 2.2. l] hept 5 ene 2,3 dicarboxy compounds 115 27 5 4,7 Methanoiosobenzofuran 1 ,bdione, 4,5,6,7,8,8 hexachloro 3a, 4,7,7a tetrahydro II 5 28 6 Chlorendic acid Structural Class Phosphoric acid, 2 chloroethyl esters 13674 87 8 P Propanol, I ,3 dichloro, phosphate (3: l)

13204 14 8 2,2 Bis( chloromethyl) trimethylene bis( bis( 2 chloroethyl) phosphate)

Structural Class Suffonaphthyl substituted 4,1 diazophenyl compounds 8003 69 8 1670 62 6 Z Naphthalenesulfonic acid, 6(( 7 amino l hydroxy 3 sulfo 2 naphthalenyl) azo) 3(( 4(( 4 amin~ 6( or 7) sulfo l naphthalenyl) azo) phenyl) azo) 4 hydroxy, trisodium salt Trisodium 6(( 2,4 diaminophenyl) azo) 3(( 4(( 4(( 7(( 2,4 diaminophenyl) azo) I hydroxy 3 sulphonato 2 naphthyl) azo) phenyl) amino) 3 suIphonatophenyl) azo)~ hydroxynaphthalene 2 suIphonate 7 I . 49536 Federal Register /Vol. 67, No. 146 /Tuesday, July 30, 2002 /Notices TABLE 3. TWENTY EIGHT EPA HPV CHALLENGE PROGRAM DEBJTS CHEMICALS continued CAS No. Chemical name Structural Class Tetrachlorobenzenes 95 94 3 1,2,4,5 Tetrachlorobenzene 634 66 2 I ,2,3,4 tetrachlorobenzene Structural Class Tris( aminoaryl) methanamimnium compounds 2152 64 9 Benzenamine, phenyl 4(( 4( phenylamino) phenyl)( 4( phenylimino) 2,5 cyclohexadien l ylidene) methyl), monohydrochloride 101 20 2 Urea, N( 4 Chlorophenyl) N'( 3,4 dichlorophenyl)

719 32 4 Terephthaloyl chloride, tetrachloro

433 06 3 1,1,2,2 Tetrachloroethylsulfenyl chloride 1203 86 7 2,2 Dichloro I( 2,4,5 trichlorophenyl) ethanone 55954 l 93 IH Atepine I carboxamide, N( 3((( hexahydro 2 oxo lH azepin l yl) carbonyl) amino) methyl) 3,5,5 trimethylcyclohexyl) hexahydro 2 oxo

60825 27 6 Acetic acid, (( 3,5,6 trichloro 2 pyridinyl) oxy), ethyl ester 64667 33 O Hexanoic acid, 4,6,6,6 tetrachloro 3,3 dimethyl, methyl ester 6980640 2 Propanoic acid, 2( 4(( 3 chloro 5( trifluoromethyl) 2 pyridinyl) oxy) phenoxy), methyl ester TABLE 4. Two HUNDRED EIGHT NON HPV DEBITS CHEMICALS WITH PREDICTED BCFs OF 3 13 CAS No. Chemical name Structual Class( 2 Thiazolylazo) benzenamines 19745 44 9 Propionitrile, 3[ p j( 5 nitro 2 thiazolyl) azo] N phenethylanilino]

68516 81 4 Ethanol, 2[ ethyl[ 3 methyl 4[( 5 nitro 2 thiazolyi) azojphenyl] aminoJ

70693 63 g Benzenamine, N, N diethyf 3 methyl 4( 2 thiazolylazo)

Structual Class[( BHydroxy l naphthalenyl) azo] benzenesulfonate salts 12688 94 7 Manganese, (4(( 5 chloro 4 methyl 2 sulfophenyl) azo) 3 hydroxy 2 naphthalenecarboxylato( 2))

5070 41 8 2 Naphthalenecarboxylic acid, 4(( 5 chloro 4 methyI 2 sulfophenyl) azo) 3 hydroxy, strontium salt (1 :I)

17852 99 2 Calcium 4(( 4 chloro 5 methyl Z suIphonatophenyl) azo) 3 hydroxy 2 naphthoate 20514 68 I 2 Naphthalenecarboxylic acid, 4(( 4 chloro 5 ethyl 2 suIfophenyl) azo) 3 hydroxy, calcium salt (1: 1)

67801 01 8 Barium bis( 5 chloro 4 ethyl 2(( 2 hydroxy l naphthyl) azo) benzenesulphonate)

67828 72 2 2 Naphthalenecarboxylic acid, 4(( 4 chforo 5 methyI 2 sulfophenyl) azo) 3 hydroxy, strontium salt (1~ 1)

Structual Class[( 3,5 Dinitro 2 thienyl) azo] anilines 14932 34 9 2,2'( 4(( 3,5 Dinitro Z thienyl) azo) 4,1 phenyleneimino) bisethanol, diacetate (ester)

58979 46 7 Acetamide, N[ 5( diethylamino) 2[( 3,5 dinitro 2 thienyl) azo] phenyl]

Structual Class[[ 3[( Phenyl) azo] phenyl] azo] benzenes 4482 25 l 1,3 Benzenediamine, 4,4'( 4 methyl 1.3. phenylene) bis( azo) bis 6 methyl

5421 m 9 1,3 Benzenediamine, 4,4'(( 4 methyl 1.3 phenyfene) bis( azo)) bis( 6 methyI, dihydrochloride 67874 26 4 Benzoic acid, ~(( 4(( 3(( 3(( 2,4 diaminophenyl) azo) 2 hydroxy 5 sulfophenyl) azo) 2,~ dihydroxyphenyl) azo) phenyl) azo) 2 hydroxy, disodium salt 71799 74 1 2,7 Naphthalenedisulfonic acid, 4(( 2,4 dihydroxy 5(( 2 hydroxy 3,5 dinitrophenyl) azo) 3(( 4 nitrophenyl) azo) phenyl) azo)% hydroxy Federal Register/ Vol. 67, No. 146 /Tuesday, July 30, 2002 /Notices 49537 TABLE 4. Two HUNDRED EIGHT NON HPV DEBITS CHEMICALS WITH PREDICTED BCFs OF 3 13 Continued CAS No. Chemical name Structual Class j[ 4[( Phenyl) azo] phenyl] azo] benzenesulfonic acid salts 51418 90 7 Benzenesulfonic acid, 3(( 4(( 4( 2 hydroxybutoxy) 3 methylphenyl) azo) 3 methoxyphenyl) azo), monosodium salt 61290 31 I Benzenesulfonic acid, 3(( 4(( 4( 2 hydroxybutoxy) phenyl) azo) 5 methoxy Z methylphenyl) azo), monolithium salt 63405 85 6 Benzenesulfonic acid, 3[[ 3 methoxy 4[( 4 methoxyphenyl) azo] phenyl] azo], sodium 68400 34 o Benzenesulfonic acid, 4[[ 4[( 4 hydroxyphenyl) azo] 5 methoxy 2 methylphenyl] azo, monosodium salt]

68959 01 3 Benzenesulfonic acid, 4 chloro 3(( 4(( 4 ethoxyphenyl) azo) phenyl) azo), sodium salt Structual Class[[ 4[( Phenyl) azo] phenyfJazo] benzenesulfonic acids 30282 44 l Benzenesulfonic acid, p[[ 2,4 dihyroxy 3( xylylazo) phneyl) azo]

Structoal Class[ 2 Methoxy 4[( 3 suIfophenyl) azo) phenyl] urea salts 7246 45 5 Benzoic acid, 2 hydroxy 5(( 4(((( 2 methoxy 4(( 3 sulfophenyl) azo) phenyl) amino) carbonyl) amino) phenyI) azo), disodium salt 10114 86 0 3,3'( Carbonylbis( imino( 3 methoxy 4, l phenylene) azo)) bis( benzenesulfonic acid), disodium salt Structual Class[ 2 Methoxy 4[( 3 sulfophenyl) azo] pheny~] ureas 8697 36 6 Benzenesulfonic acid, 3,3'( carbonylbis( imino( 3 methoxy 4,1 phenyiene) azo)) bis

Structual Class I[( Dinitrophenyl) azo] 2 naphthalenols 4998 82 7 1[( 2 Hydroxy 3,5 dinitrophenyl) azo] 2 hydroxynaphthaiene Structual Class 1 H lndole B sulfonic acid, 2 phenyf 3[[ 2( phenylsulfonyl) phenyl] azo] 1 H Indole sulfonic acid salts 90677X3 7 It i Indole sulfonic acid, 2 phenyl 3[( 2( phenylsulfonyl) phenyl] azo], monosodium salt Structual Class IH lndole 5 sulfonic acid, 2 phenyl 3[~ 2( phenylsulfonyf) phenyl] azo] IH lndole 5 sulfonic acids 93972 88 4 IH lndole+ sulfonic acid, 2 phenyl 3[[ 2( phenylsulfonyl) phenyl] azo]

Structual Class 2( Phenylazo) 3 oxo N phenylbutanamides 2512 29 O Butanamide, 2[( 4 methyl 2 nitrophenyl) azo] 3 oxo N phenyl

6486 21 2 Acetoacetanilide, 2[( 4 methoxy 2 nitrophenyl) azo]

6466 23 3 Butanamide, 2[( 4 chloro 2 nitrophenyl) azo] N( 2 chlorophenyl) S oxo

12225 l 6 2 Butanamide, N( 4 chloro9,5 dimethoxyphenyl) 2(( 2,5 dimethoxy4(( phenylamino) sulfonyl) phenyi) azo) 3 oxo

13515 40 7 o Acetoacetanisidide, 2[( 4 chloro 2 nitrophenyl) azo]

32432 45 4 o Acetoacetotoluidide, 4' chloro 2[( 4 chloro 2 nitrophenyl) azo]

52320 66 8 2(( 4 Chloro 2 nitrophenyl) azo) N( 4 ethoxyphenyl) 3 oxobutyramide Structual Class 2.4 bis[( Arylazo) arylamino]& amino 1,3,5 triazines 104 03 8 2 Naphthalenesulfonic acid, 7,7'(( 6( 4 morpholinyl) l, 3,5 triazine 2,4 diyl) diimino) bis( 4 hydroxy 3(( 4 methoxy 2 sulfophenyl) azo), tetrasodium salt 50925+ 2 3 1,5 Naphthalenedisulfonic acid, 3,3'(( 6(( 2 hydroxyethyl) amino) l, 3,5 triazine 2.4 diyl) bis( imino( 2 methyl 4~ 1 phenylene) azo)) bis, tetrasodium salt 52953 36 3 Cuprate( 4),( 4 hydroxy 7(( 4(( 2 hydroxyethyl) amino) 6(( 5 hydroxy 6(( 2 hydroxy 5 sulfophenyl) azo) 7 sulfo 2 naphthalenyl) amino) 1 ,3,5 triazin 2 yl) amino) 3(( 4 methoxy 2 sulfophenyl) azo) 2 naphthalenesulfonato( 6)), tetrasodium Struck& Class 2[[ 6[( 1,3,5 Triazin 2 yl) amino] l hydroxy 3 suIfo 2 naphthalenyl] azo] 1 ,5naphthalenedisulfonic acid salts 70616 90 Q I ,5 Naphthafenedisulfonic acid, 2(( 6(( 4,6 dichloro 1 ,3,5 triadn 2 yl) methylamino) l hydroxy 3 sulfo 2 naphthalenyl) azo), trisodium salt 4953% Federal Register / Vol. 67, No. 146 /Tuesday, July 30, 2002 /Notices TABLE 4. Two HUNDRED EIGHT NON HPV DEBITS CHEMICALS WITH PREDICTED BCFs OF 3 13 Continued CAS No. Chemical name 8992344 4 Trisodium 2(( 6(( 4( ethylphenylamino 6 fluoro l, 3,5 triazin 2 yl) amino) l hydroxy 3 sulphonato Z naphthyl) azo) naphthaiene 1 ,LGdisulphonate 12236 62 3 68134 22 5 Structual Class 2 Azo N( 2,3 dihydro 2 oxo lH benzimidazol 5 yl) 3 oxobutanamides Butanamide, 2(( 4 chloro Znitrophenyl) azo) N( 2,3 dihydro 2 oxo l H benzimidazol+ yl) 3 oxo

Butanamide, ( 2,3 dihydro 2 oxo 1H bentimidazol 5 yO 3 oxo 2(( 2( ttif~ uoromethyl) phenyl) azo)

Structual Class 2 Halo%( phenylazo) G [((( sulfonaphthyi) azo) sulfophenyl) aminoJ i, 3, btriazines 68110 31 6 2,7 Naphthalenedisulfonic acid, 4 amino 3,6 bis(( 4(( 4 chloro 6(( 3 sulfophenyl) amino) l ,3,5 triazin 2 yl) amino) Z sulfophenyl) azo) d hydroxy, hexasodium salt 66133 244 2,7 Naphthalenedisulfonic acid, 4 amino 3,6 bis[~ 5[[ 4 chloro 8[( 3 sulfophenyi) amino] l ,3,5 tnazin 2 yl] amino] 2sulfophenyl] azo] 5 hydroxy, hexasodium salt 70528 69 l 2,7 Naphthalenedisulfonic acid, 4 amino 6(( 5(( 4(( 3 chlorophenyl) amino) 6~ uoro l, 3,5 triazin 2 yl) amino) 2 sulfophenyl) azo) 5 hydroxy 3(( 4 sulfophenvl) azo), tetrasodium salt Structual Class 3[[ 4[( 6 Nitro 2 benzothiazolyl) azo] phenyl] amino] propanenitriles 13486 43 6 Ethanol, 2 ethyl 4( 6 methoxy 2 benzothiazolvhazo phenvl amino

16586 42 8 Propanenitrile, 3 ethyl 3 methyl 4( 6 nitro 2 benzothiazolyl) azo phenyl amino

16588 67 3 Propionitrile, 3 N ethyl 4 6( methylsulfonyl) 2 benzothiazolyl azo, m toluidino

25510 81 o Propanenitrile, 3( ethyl( 4(( 6 nitro 2 benzothiazolyl) azo) phenyl) amino)

41362 82 7 Propanenitrile, 3 4( 5,8 dichloro 2 benzothiazolyl) azo phenyl methylamino

Structual Class 3[[ 4(( Phenyl) azo] l naphthalenyl] azo] benzenesulfonic acids, sodium salts 67875 21 2 Benzenesulfonic acid, 3 f[ 4 j( 2 hydroxy 5 methylphenyl) azoJ 1 naphthalenyl] azo], monosodium salt 68959 00 2 Benzenesulfonic acid, 3(( 4(( 2 ethoxy 5 methylphenyl) azo) l naphthalenyl) azo), sodium salt Structual Class 3[[ Phenyl] azo] N( phenyl) benzenecarboxamides 12236 64 5 2 Naphthalenecarboxamide, ( 4( acetylamino) phenyl) 4((!%( aminocarbonyi) 2 chlorophenyl) azo) 3 hydroxy

36988 27 l 2 Naphthalenecarboxamide, 4[[ 4( aminocarbonyl) pohenyl] azo] 3 hydroxy N( 2 methoxyphenyl)

19904 524 I  2 Naphthatenecarboxamide, 3 hydroxy 4(( 2 methoxy 5(( phenylamino)~~ onyl) phenyl) azo)

Structual Glass 4,4' bis( Arylazo) stilbene 2,2' disulfonic acid salts 2870 32 6 2,2'( 1,2 Ethenediyl) bis( S(( 4 ethoxyphenyl) azo) benzenesulfonic acid), disodium salt 53523 90 3 ) Benzoic acid, 3,3'[ 1,2 ethenediylbis[( 3 sulfo 4,1 phenylene) azo]] bis [6 hydroxy 5 methyl, tetralithium salt 75701 34 7 2 Naphthatenesulfonic acid, 3,3'( 2,2 ethenediylbis[( 3 sulfo 4,1 phenylene) azo]] bis[ 6 amino 4 hydroxy. cmpd with 2,2', 2" nitrilofris (ethanol) (1: 4)

91 34 9 37138 26 4 41098 56 O 17506 54 5 68003 30 5 Structual Class4,4' bis( Arylazo) stilbene 2,2' disulfonic acids Benzenesulfonic acid, 2,2'( 1,2 ethenediyl) bis 5( 4 hydroxyphenyl) azo

Structual Class4,4' bis( Triazinylamino) stilbene 2,2' disulfonic acid salts Benzenesulfonic acld. 2,2'( 1,2 ethenediyl) bis[ 5[[ 4 chloro 6[( 4 sulfophenyl) amino] 1,3,5 triazin 2 yl] amino], tetrasodium salt 1,4 Benzenedisulfonic acid, 2,2'( 1,2 ethenediylbis(( 3 sulfo 4,1 phenylene) imino( 6( diethylamino) l, 3,5 triazine 4,2 diyl) imino)) bis, hexasodium salt Benzenesulfonic acid, 2,2'( 1,2 ethenediyl) bis( 5(( 4( bis( 2 hydroxypropyl) amino) 6(( 4 sulfophenyl) am~ no) 1,3,5 triazin Z yl) amino), dipotassium disodium salt Benzenesulfonic acid, 2,2'( 1,2 ethenediyl) bis( 5(( 4( 2 hydroxypropoxy) 6( phenyiamino) l, 3,5 triazin 2 yl) amino), disodium salt Federal Register /Vol. 67, No. 14R /Tuesday, July 30, 2002 /Notices 49539 TABLE 4. Two HUNDRED EIGHT NON HPV DEBITS CHEMICALS WITH PREDICTED BCFs OF 3 13 Continued I CAS No. I Chemical name ~~ ~ I 68003 31 6 Benzenesulfonic acid, 2,2'( 1 ,2 ethenediyl) bis[ 5[[ 4[ 2( 2 hydroxyethoxy) ethoxy] 6[ phenylamino] l ,3,5 triazin 2 yi] aminoJ, disodium salt 68025 20 7 Benzenesulfonic acid,%(( 4( 2( 2 hydroxyethoxy) ethoxy) 6( phenylamino) l, 3,5 triazin 2 yl) amino) 2( 2( 4(( 4 (2 hydroxypropoxy) 6( phenylamino) I ,3,5 triazin 2 yl) amino) 2 sulfopheny~) ethenyl), disodium salt 68155 68 O Benzenesulfonic acid, 2,2'( 1 ,2 ethenediyl) bis( 5(( 4 chloro 6(( 4 sulfophenyi) amino) l ,3,5 triazin 2 yl) amino), dipotassium disodium salt 85187 74 2 Benzenesulfonic acid, 2,2'( 1,2 ethenediyl) bis@(( 4( methylamino) 6 (phenylamino) l, 3,5 triazin 2 yl) amino), sodium salt I I Structual Class 4 Amino 4' nitroazobenzenes 101 52 o 2 Methoxy+[( 4 nitrophenyl) azo] benzenamine 1 1533 76 2 / Propanamide, ( 5( bis( 2( acetyioxy) ethyl) amino) 2(( 4 nitrophenyl) azo) phenyl)

I 1533 77 3 Acetanilide, 5'( bis( 2 hydroxyethyl) amino) 2'(( 2 methoxy 4 nitrophenvl) azo). diacetate (ester)

] 1533 78 4 ) Acetamide, ( 5( bis( 2( acetyloxy) ethyl) amino) 2(( 2 chioro 4 nitrophenyi) azo) phenyl)

2872 52 8 3025 41 O 2( Ethyl( 4(( 4 nitrophenyl) azo) phenyi) amino) ethanol Ethanol, 2,2' 4( 2 chloro 4 nitrophenyl) azo phenyl imino bis

3179 89 3 Ethanol, 2,2' 3 methyl 4( 4 nitrophenyl) azo phenyl imino bis

3180 81 2 Ethanol, 2, 4( 2 chIoro+ nitrophenyl) azo phenyl ethylamino

3618 73 3 Acetamide, ( S( bis( 2( acetyloxy) ethyl) amino) 2(( 2 ch~ oro 4,6 dinitrophenyl) azo) 4 me~ oxyphenyl)

1 4058 30 4 1 Propanenitrile, 3,3'(( 4(( 2 chloro 4 nitrophenyl) azo) phenyl) imino) bis

5261 31 4 6021 61 o Propanenitrile, 3(( 2( acetyloxy) ethyl){ 4(( 2,6 dichtoro 4 nitrophenyl) azo) phenyl) amino)

Propionitrile, 3[ p[( 2 chloro 4 nitrophenyl) azo] N( 2 hydroxyethyl) anilino],

6657 32 5 Propionitrile, 3[ N( 2 hydroxyethyt) p I( p nitrophenyl) azoJaniiino]

13301 61 6 Propionitrile, 3[ p f( 2,6 dichloro 4 nitrophenyl) azo] N ethylanilino]

1 16586 43 9 Propanenitrile, 3[~ 4[( 2 chloro 4 nitrophenyl) azo] 3 methylphenyl] ethyfamino]

5474 89 3 Benzonitrile, Z[[ p[( Z cyanoethyl) ethylamino] phenyl] azo] 5 nitro

17464 91 4 Ethanol, 2,2'(( 4(( 2 bromo 6 chloro 4 nitrophenyl) azo) 3 ch~ orophenyl) imino) bis

17741 62 7 Thiomorpholine, 4 p( 2,6 dichloro 4 nitrophenyl) azo phenyl, l, I dioxide 22578 86 5 Acetamide, N( 2(( 2 bromo 4,6 dinitrophenyl) azo) 5(( 2 cyanoethyl) ethylamino) 4 methoxyphenyl)

23355 64 8 Ethanol, 2,2'[[ 3 chloro 4[( 2,6 dichloro 4 nitrophenyl) azo] phenyl] imino] di

24170 60 3 Acetamide, N 2( 2 cyano 4,6 dinitrophenyl) azo 5( diethylamino) phenyl

29426 52 6 29649 47 e Ethanol, 2,2' 3 methyl 4 2( methylsulfonyl) 4 nitrophenyl azo phenyl imino bis, diacetate ester Acetamide,( 2(( 2 chloro 4 nitrophenyl) azo) 5(( 2( 2,5 dioxo 1 pyrrolidinyl) ethyl) ethylamino) phenyl)

I 10177 47 6 1 Benzamide, N 5 bis 2( acetyloxy) ethyl amino 2( 4 nitrophenyl) azo phenyl I 30124 94 8 Benzonitrile, 2 4 bis 2( acetyloxy) ethyl amino phenyl azod nitro

31464 38 7 Propanenitrile, 3 methyl&( 4 nitrophenyl) azo phenyl amino

I 31482 56 l Propanenitrile, 3 ethyC4( 4 nitrophenyl) azo phenyl amino I 40690 S 9 40880 51 I Propanenitrile, 3[[ 2( benzoyloxy) ethyl][ 4[( 4 nitrophenyl) azo] phenylJamino~

Propanenitrile, 3 4( Z chloro+ nitrophenyl) azo phenyl ethylamino

I 41642 51 7 Acetamide, 2( 2,6 dicyano 4 nitrophenyl) azo 5( diethyfamino) phenyl I 49540 Federal Register / Vol. 67, No. 146 /Tuesday, July 30, 2002 /Notices TABLE 4. Two HUNDRED EIGHT NON HPV DEBITS CHEMICALS WITH PREDICTED BCFs OF 3 13 Continued CAS No. I Chemical name 43047 20 J 52697 38 8 53950 33 7 56548 64 2 61355 92 8 22487049 65916 12 3 66214 54 8 66882 l 64 67674 22 O 67846 62 Z 67874 57 q 67923434 68391 42 4 68391 47 9 68957 67 5 70210 10 5 71617 28 2 72968 78 6 75150 12 7 67875 18 7 67875 11 O 67875 14 3 68039 07 6 68039 08 7 4399 55 7 68227 72 5 70210 31 O 530 08 7 1593 37 I Ethanol, 2,2 chloro 4( 4 nitrophenyl) azo phenyl amino

A& amide, [ 2[{ 2 bromo 4,6 dinitrophenyl) azo] 5( diethylamino) phenyl]

Acetamide. ( 2(( 2 bromo 4,6 dinitrophenyl) azo) 5(( 2 cyanoethyl) amino) 4 methoxyphenyl)

Acetamide, [ 2[( 2 bromo 4,6 dinittophenyl) azo] 5( diethytamino)~ methoxyphenyl)

.beta. Alanine,  3( acetylamino) 4 (Cnitrophenyl) azo phenyl N( 3 methoxy 3 oxopropyl), methyl ester Ethanol, 2,2' 4( 2,6 dichloro 4 nitrophenyl) azo phenyl imino bis

Acetamide. ( 2(( 2,6 dicyano 4 nitrophenyl) azo) 5(( 2( 2 ethoxyethoxy) ethyl) ethylamino) phenyl)

Ethanol, 2,2' 4.( 4 nitrophenyI) azo phenyl imino bis, diacetate (ester)

Benzonitrile, 2[[ 4[ bis[ 2( acetyloxy) ethyl] amino] 2 methylphenyl] azo] 5 nitro

Acetamide, 2( 2 btomo 4,6 dinitrophenyl) azo 5( ethyiamino) 4 me~ hoxyphenyl

Propanamide, ( 2(( 2 chloro 4,6 dinitrophenyl) azo) 5( ethylamino) 4( 2 mefhoxyethoxy) phenyl)

Propanenitrile, 3 2 chloro+( 2,6 dichloro+ nitrophenyl) azo phenyl amino

Propanenitrile, 3,3' 4 (2,6 dichloro 4 nitrophenyl) azo phenyl imino bis

Propanenitriie, 3[[ 2( acetyloxy) ethyi][ 4~( 4 nittophenyl) azo] phenyl) amino]

Acetamide, N+ bis 2( acetyloxy) ethyl amino 2( 2,4 dinitrophenyl) azo phenyl

Acetamide, N( 2(( 2 chloro 4,6 dinitrophenyl) azo) 5( ethylamino) 4( 2 metho~ ethoxy) phenyl)

Propanenitrile, 3(( 2( 2 cyanoethoxy) ethyl)( 4(( 4 nitrophenyl) azo) phenyl) amino)

Acetamide, N( 4 chloro 2(( 2 chloro 4 nitrophenyl) azo) 5(( 2 hydro~ propyi) amino) phenyl)

2,4,10 Trioxa 7 azaundecan 1 I oic acid, 7( 4(( 2 cyano 4 nitrophenyl) azo) 3 methyiphenyl) 3 oxo, methyl ester Acetamide, ( 2(( 2 chloro 4 nitrophenyl) azo) 5(( 2 cyanoethyl) 2 propenylamino) phenyl)

Structual Class 5( Phenylazo) 8( phenylamino) l naphthalenesulfonic acid salts I Naphthalenesulfonic acid, 5(( 2 chloro 4 nitrophenyl) azo) 8 phenylamino, sodium salt I Naphthalenesulfonic acid, 5[( 3 chlorophenyl) azo]&( phenylamino), monosodium Structual Class 5,8 bis( phenylazo) 2 suifonaphthalenes Z Naphthalenesulfonic acid, 5(( 4( bis( 2 hydroxyethyl) amino) phenyl) azo) 8(( 2 methylphenyl) azo), mono sodium salt 2. Naphthalenesuifonic acid, 5( or 8)(( 4 hydroxy 2 methylphenyl) azo) 8( or 5)( phenylazo), monosodium salt 2 Naphthalenesulfonic acid, 5( or 8)(( 4 ethoxy 2 methylphenyl) azo) 8( or 5)( phenylazo), sodium salt Structual Class 5& bis[( naphthyl or phenyl) azo] 2 sulfonaphthalenes 1,5 Naphthalenedisulfonic acid, 3(( 4(( 4(( 6 amino l hydroxy 3 sulfo 2 naphthalenyl) azo) 6 sulfo l naphthalenyl) azo) I naphthalenyl) azo), tetrasodium salt I Naphthalenesulfonic acid, 8( phenylamino) 5(( 4( phenylazo) 6 sulfo l naphthalenyl) azo), disodium salt 2 Naphthalenesulfonic acid, 8(( 4(( 4 amino 3 suifophenyl) azo) 6 sulfa I naphfhalenyl) azo) 5(( 6. (benzoylamino) l hydroxy 3 sulfo 2 naphthalenyl) azo), tetrasodium salt Structual Class 5[[ 4[( 3 Sulfophenyl) azo] l naphthalenyl] azo] naphthalene sulfonic acid salts I Naphthalenesulfonic acid, 8( phenylamino) 5(( 4(( 3 sulfophenyl) azo) 1 naphthalenyl) azo), disodium salt 2 Naphthalenesulfonic acid, 6 hydroxy 5(( 4(( 4( phenylamino) 3 sulfophenyl) azo) l naphthalenyl) azo) ,disodium salt x Federal Register / Vol. 67, No. 146 /Tuesday, July 30, 2002 /Notices TABLE 4. Two HUNDRED EIGHT NON HPV DEBITS CHEMICALS WITH PREDICTED BCFs OF 3 13 Continued CAS No. Chemical name Structual Class 5 Azo 2,6 dialkylamino 4 methyl 3 pyridinecarbonitriles 63833 78 3 72968 71 9 3 Pyridinecarbonitrile, 5 (2. cyano 4 nitrophenyl) azo 6 (2 hydroxyethyl) amino 2 Thiophenecarboxylic acid, 4 cyan~ 5(( 5 cyano 2,6 bis(( 3 methoxypropyl) amino) 4 methyl 3 pyridinyl) azo) 3 methyl, methyl ester Structual Class Azobis( 4,1 phenyleneazo) bis( naphthalenesulfonates)

52469 75 7 Trisodium 5 amino 3(( 4(( 4(( 7 amino l hydroxy 3 sulphonato 2 naphthyl) azo) phenyl) azo) phenyl) azo) 4 hydroxynaphthalene 2,7 disulphonate 72017 89 I 72017 91 5 2,7+! aphthalenedisulfonic acid, 3,3'( azobis( 4,1 phenyieneazo)) bis( 5 amino 4 hydroxy, tetrasodium salt 2,7 Naphthalenedisulfonic acid, 5 amino 3(( 4(( 4(( 8amino S hydroxy 3,6 disulfo 2 naphthalenyl) azo) 3 methoxyphenyl) azo) phenyl) azo) 4 hydroxy, tetrasodium salt 75173 68 1 Copper, (mu(( 3,3'( azoxybis(( 2 hydroxy 4, l phenylene) azo)) bis( 4 hydroxy 2,7 naphthalenesulfonato))(&))) di, tetrasodium 93941 06 l 99869 36 O 99869 37 I <24605 62 Q 2,7 Naphthalenedisulfonic acid, 3,3'( azoxybis(( Z methoxy 4, l phenylene) azo)) bis( 4, bdihydroxy

2,7 Naphthalenedisulfonic acid, 3,3'( azoxybis(( 2 methoxy 4,1 phenylene) azo)) bis( 4,5 dihydroxy~ lithium salt 2,7 Naphthalenedisulfonic acid, 3,3'( azoxybis(( 2 methoxy 4,1 pheny~ ene) azo)) bis( 4,5 dihydroxy, sodium salt 2,7 Naphthalenedisulfonic acid, 5 amino 3[[ 4[[ 4(( 8 amino l hydroxy 3,6 disu~ fo 2 naphthalenyl) azo]~ Z methylphenyl] azo] 4 hydroxy, lithium sodium salt Structual Class Biphenylbis( azonaphthalenesulfonates)

4198 19 O 2,7 Naphthalenedisulfonic tetrasodium salt acid, 3,3'(( 3,3' dimethoxy( 1 ,l' biphenyl) 4,4' diyl) bis( azo)) bis( 4,5 dihydroxy,

3770 03 3 Cuprate( 4), (mu(( 4,4'(( 3,3' di( hydroxy kappaO)( l, Z' biphenyl)~, 4' diyl) bis( azo kappaNl)) bis( 3( hydroxy kappaO) 2,7 naphthalenedisulfonato))( 8))) di. tetrasodium 28407 37 6 2,7 Naphthalenedisulfonic acid, 3,3'(( 3,3' dihydroxy( l, l' biphenyl) 4,4' diyl) bis( azo) bis( 5 amino 4 hydroxy, so dium salt, copper complex 66418 17 5 Cuprate( [. mu.[ 4[[ 4'~( 6 amino l hydroxy 3 sulfo 2 naphthalenyl) azo] 3,3' dihydroxy( 1 ,I' biphenyl) 4 yl) azo] 3 hydroxy 2,7 naphthalene disulfonato( 7)] Jdi, trisodium 67952 80 I Cuprate( 4), (mu( 5( acetylamino) 3(( 4'(( 8 amino 1 hydroxy 3,6 disulfo 2 naphthalenyl) azo) 3,~ dihydroxy( l, l' biphenyl) 4 yl) azo) 4 hydroxy 2,7 naphthalenedisulfonato( 8))) di, tetrasodium 68133 82 4 68259 04 I Chromate( Z), bis( 2(( 6 amino l hydroxy 3 sulfo Z naphthalenyl) azo) benzoato( 3)), dihydrogen Acetic acid, 2,2'(( 4,4' bis(( 6(( 1 hydroxy 4((( 2 methoxyethoxy) carbaryl) amino) phenyl) amino) 3 sulfo 2 naphthalenyl) azo( l, 1' biphenyi) 3.3' diyI) bis( oxy)) bis, disodium salt 71550 22 6 2,7 Naphthaienedisulfonic acid, 3,3'(( 3,3' dimethoxy( l, 1' biphenyl) 4,4' diyI) bis( azo)) bis( 5 amino~ hydrox~, tetraiithium salt 71873 63 7 Cuprate( ~. mu.[ 7[[ 3,3' dihydroxy 4'[( 4 hydroxy 2 sulfobenzo[ a] phenazin 3 yl) azo kappaN1)( 1,1' biphenyl)~ 4 yl) azo kappaNl) 8( hydrozy kappaO) 1 ,3,6 naphthalenetrisulfonato(&))) di, tetrasodium salt Structual Class Bis[ 1', 2' dihydro 6' hydroxy 4'nethyl 2' oxo l, 3' bipyridiniums]

71032 99 O 1,3' Eipyridinium, 5', 5"`( 1 ,2 ethanediylbis( 4,2 phenyleneazo)) bis( l',~~ ihydro~ hydroxy~ methyl~~ xo~, salt with 2 hydroxypropanoic acid (1: 2)

75214 63 O 650528 g 7147 42 4 1,3' Bipyridinium, 5'[[ 4[[ 4[( 1', 2' dihydro 6' hydroxy 3,4' dimethyl 2' oxo[ l ,3' bipyridinium)&` yl) azo) benzoyl) amino) phenyl) azo) l', 3' dihydro 6' hydroxy 3,4' dimethyl 2' oxo, salt with 2 hydroxypropanoic acid (1: 2)

Structual Class Bis[ 2( phenylazo) 3 oxo N phenylbutanamides]

Butanamide, 2,2'(( 3,3' dimethoxy( 1,1' biphenyl) 4,4' diyl) bis( azo)) bis( 3 oxo N phenyl

Butanamide, 2,2'(( 3,3' dimethoxy( l, 1' biphenyl) 4,4' diyl) bis( azo)) bis( N( 2 methyIphenyl) 3 oxo

13 49542 Federal Register /Vol. 67, No. 146 I Tuesday, July 30, 2002 /Notices TABLE 4. Two HUNDRED EIGHT NON HPV DEBITS CHEMICALS WITW PREDICTED BCFs OF 3 13 Continued CAS No. I Chemical name 681.55 71 5 Benzamide, 4(( 1((( 2 methoxyphenyl) amino) carbonyl) 2 oxopropyl) azo) N( 4(( 1((( 2 methoxyphenyl) amino) carbonyl) Z oxopropyl) azo) phenyl)

68516 73 4 1,4 Benzenedicarboxylic acid, 2,2'[ I ,4 phenylenebis[ imino( I acetyl 2 oxo 2,1 ethanediyl) azo)) bis, tetramethyl ester 77804 81 O Butanamide, 2,2'( 1,2 ethanediylbis( oxy 2,1 phenyleneazo)) bis( N (2,3 dihydro 2 oxo IH benzimidazol. 5 yl) 3 oxo

Structual Class Diaminoanthraquinones 4403 90 I m Toluenesulfonic acid, 6,6'( 1,4 anthraquinonylenediimino) di, disodium salt 67827 60 5 2 Anthracenesulfonic acid, l amino 4(( 3(( benzoylamino) methyl) 2,4,6 trimethylpheny~) amino) 9, lO dihydro 9,10 dioxo, monosodium salt 67969 88 4 P Anthracenesulfonic acid, l amino 4(( 4((( 4 methylphenyl) sulfonyl] oxy] phenyl) amino) 9, lO dihydro Q. l0 dioxo, monosodium salt 67970 27 8 Benzenesulfonic acid, 2,2'(( 9, lO dihydro 9,1O dioxo l, 4 anthracenediyl) diimino) bis( 5 methyl, diammonium salt 72391 24 3 Benzenesulfonic acid, [[( chloroacetyl) amino] methyl]~ 4[[ 4( cyciohexylamino) Q, lO dioxo l anthracenyl) amino) phenoxy) methyl, monosodium salt Structual Class N( 2,3 dihydro 2 oxo lH benzimidazol 5 yl) 4 [[ 4[( methylamino) suIfonyl] phenyl] azo] 3 hydroxy 2 naphthalenecarboxamides 3771 33 9 2 Naphthalenecarboxamide, ( 2,3 dihydro 2 oxo~ H benzimidazoI 5 yl) Q(( 2,5 dimethoxy 4 (( methyiamino) sulfonyl) phenyl) azo) 3 hydroxy

Structual Class ( 2.3 dihydro 2 oxo IH benzimidazol+ yl)+ [[ 4[( methylamino) sulfonyl] phenyl] ato] 3 hydroxy 2 naphthalenecarboxamides 18269 75 6 2 Naphthalenecarboxamide,( 2,3 dihydro 2 oxo lH benzimidazol 5 yl) 3 hydroxy 4(( 2 methox~ 5 methyl 4 (( methylamino) sulfonyl) phenyl) azo)

61951 98 2 Structual Class N( atylazo) phenyl (disuIfonaphthyl) azobenzamides 70900 28 6 2,7 Naphthalenedisulfonic acid, cl amino 3(( 4((( 4(( 4 amino 2 hydroxyphenyl) azo) phenyl) amino) carbonyI) phenyl) azo) 5 hydroxy 6(( 4 sulfophenyl) azo), trisodium salt 72245 55 7 2,7 Naphthalenedisulfonic acid, 4 amino 3(( 4((( 4(( 7 amino l hydroxy 3 sulfo 2 naphthalenyl) azo) phenyl) amino) carbonyl) phenyl) azo)~ hydroxy 6( phenylazo), sodium salt 72245 57 9 2,7 Naphthalenedisulfonic acid, 4 amino 3(( 4((( 4(( 2 amino 4 hydroxyphenyl) azo) phenyl) amino) carbonyl) phenyl) azo) 5 hydroxy 6( phenylazo), sodium salt 3441 14 3 3626 36 6 7925.5 95 l 68385 96 6 72968 82 2 63134 15 6 67338 62 9 Structual Class N, N' bis[( arylazo) sulfonaphthyl] urea salts 2 Naphthalenesulfonic acid, 3(( 4( acetylamino) phenyl) azo) 4 hydroxy 7(((( 5 hydroxy 6( phenylazo) 7 sulfo 2 naphthalenyl) amino) carbonyl) amino), disodium salt 2 Naphthalenesulfonic acid, 7,7'( carbonyldiimino) bis( 4 hydroxy 3( phenylazo), disodium salt 2 Naphthalenesulfonic acid, 7,7'( carbonyldiimino) bis( 4 hydroxy 3(( 2 methyl~ sulfophenyl) azo), sodium salt, compd. with 2,2', 2" nitrilotris( ethanol)

Structual Class N[ 2[( 2,6 dicyano l methylphenyl) azo] 5( dialkylamino) phenyljmethanesulfonamides Methanesulfonamide, [ 2[( 2,6 dicyano 4 methylphenyl) azo] 5( diethylamino) phenyl]

Methanesulfonamide, N 2( 2,6 dicyano 4 methylphenyl) azo 5( dipropylamino) phenyl Structual Class N[ S( amino) 2([ 5( ethylthio) 1 ,3,4 thiadiazol 2 yl] azo] phenyl] acetamides Acetamide, 5( dipropylamino) 2 5( ethylthio) l, 3,4 thiadiazol 2 ylazo phenyl

Acetamide, ( 5( ethyl( phenylmethyl) amino) 2(( 5( ethylthio) l ,3,4 thiadiazol 2 yl) azo) phenyl) Federal Register / Vol. 67, No. 146 /Tuesday, July 30, 2002 /Notices 49543 TABLE 4. Two HUNDRED EIGHT NON HPV DEBITS CHEMICALS WITH PREDICTED BCFs OF 3 13 Continued CAS No.

20025 74 5 Chemical name Structual Class Sulfonaphthyl substituted 4, l diazophenyl compounds 1,3,5 Naphthalenetrisulfonic acid, 7(( 4(( 4(( 2,5.6 trichloro 4 pyrimidinyl) amino) phenyl) azo) pheny~) azo), tri sodium salt 68460 07 I 124649 82 7 67969 92 O 72066 88 7 3214 47 g 28706 21 o 28706 22 I 67969 87 3 71873 47 7 2390 59 2 2390 60 5 2580 56 5 1064 48 8 1580 44 I 2,7 Naphthalenedisulfonic acid, 4 amino 3[[ 4[( 2 amino 4 hydroxyphenyl) azo] phenyl] azo] 5 hydroxy 6 (phenylazo), disodium salt 2 Naphthalenesulfonic acid, 4 hydroxy 3[[ 2 methoxy 5 meth~~[( 4 sulfophenyl) azo] phenyl] azo]` l (phenylamino), cmpd. with [nitrilotris( 2,1 ethanediyioxy)] tris[ propanol] (1: 2)

Structual Class Sulfonaphthyl substituted diphenylamine 4,4' diazo 2 sulfonic acid salts 2 Naphthalenesulfonic acid, 6 amino 3[[ 4[[ 4[( 7 amino l hydroxy 3 sulfo 2 naphthalenenyl] azo] phenyl] amino] 3 suifophenyl] azo] 4 hydroxy, trisodium salt Structual Class Sulfonaphthyl substituted diphenylamine 4,4' diazo 2 sulfonic acids 2,7 Naphthalenedisulfonic acid, 4 amino 3(( 4(( 4(( 2 amino 4 hydroxyphenyl) azo) phenyl) amino) 3 sulfophenyi) azo) 5 hydroxy 6( phenylazo)

Structual Class Sulfonaphthyl substituted N, N' bis( azophenyl) urea salts 1,5Naphthalenedisulfonic acid, 3,3'( carbonylbis( imino( 2 methyl 4,1 phenylene) azo)) bis, tetrasodium salt 1,3 Naphthalenedisulfonic acid, 7,7'( iminobis( carbonyl( 2 methyl 4, I phenylene) azo)) bis, tetrasodium salt 1,5Naphthalenedisulfonic acid, 3,3'( carbonyibis( imino( 3 methoxy 4,1 phenylene) azo)) bis, tetrasodium salt 1,3 Naphthalenedisulfonic acid, 7(( 4(((( 2 methoxy 4(( 3 sulfophenyl) azo) phenyl) amino) carbonyl) amino) 2 methylphenyl) azo), trisodium salt Benzoic acid, 3(( I hydroxy 6(((( 4~((& hydroxy 3,6 disulfo I naphthalenyl) azo) 2 methoxy 5 methylphenyl) amino) carbonyl) amino) 3 sulfa 2 naphthalenyl) azo) 4 methoxy, tetrasodium salt Structual Class Tris( aminoaryl) methanamimnium compounds Ethanaminium, ( 4( bis( 4( diethylamino) phenyl) methyiene) 2,5 cyclohexadien l ylidene) N ethyl, chloride Ethanaminium, ( 4(( 4( diethylamino) phenyl)( 4( ethylamino) l naphthalenyl) methylene) 2, dcyclohexadien l ylidene) N ethyl, chloride 2 Methanaminiom, N( 4(( 4( dimethylamino) phenyl)( 4 (phenylamino) I naphthalenyi) methylene) 2,5 cyclohexadien I ylidene) N methyl. chloride 2,7 Naphthalenedisulfonic acid, rl amino 5 hydroxy 3(( 4 nitrophenyl) azo) 6( phenylazo), disodium salt 2 Naphthalenesulfonic acid, 7 amino 4 hydroxy 3(( 5 hydroxy 6( phenylazo) 7 suif~ 2 naphthalenyl) azo), diso diom salt 6527 70 4 1789 01 9 12239 34 8 4232 06 2 41680 76 6 18386 01 7 58104 55 5 64181 81 3 67800 97 g 67905 39 9 2,9 Yriphenodioxatinedisulfonic acid, 6,13 dichloro 3,10 bis( phenylamino), disodium salt Cuprate( 2), (mu(( 7,7' iminobis( 3(( b( aminosuIfonyl) 2( hydroxy kappaO) phenyi) azo kappaNl)+( hydroxy kappaO) 2 naphthalenesulfonato))( 6))) di, disodium Acetamide, ( 5( bis( 2( acetyloxy) ethyl) amino) 2(( 2 bromo 4,6 dinitrophenyl) azo) 4 ethoxyphenyl)

Benzenemethanamine, N ethyl N 4( 1 H 1,2,4 triazol 3 ylazo) phenyl

1,4 Benzenedicarboxylic acid, 2,5 bis( 4 chlorophenyl) amino

.beta. Alanine, N ethyl N~ 4[( 5 nitro 2,1 benzisothiazol 3 yl) azoJphenyl], methyl ester 2 Naphthalenesulfonamide, 6 hydroxy N( 2 hydroxyethyl) N methyl 5(( 4( phenylazo) phenyl) azo)

7(( 4 Chloro 6(( 3 sulfophenyl) amino) l, 3,5 triazin 2 yl) amino) 4 hydroxy 3(( 4 methoxy 2 sulfophenyl) azo) 2 naphthalenesulfonic acid, trisodium salt Chromate( l), bis( 3( 4(( 5 chloro 2 hydroxyphenyl) azo) 4,5 dihydro 3 methyl 5 oxo IH pyrazol I yl) benzene sulfonamidato( 2), sodium Aluminum, tris( triacontyl)

 ..~   49544 Federal Register/ Vol. 67, No. 146 /Tuesday, July 30, 2002 /Notices TABLE 4. Two HUNDRED EIGHT NON HPV DEBITS CHEMICALS WITH PREDICTED BCFs OF 3 I$ Continued CAS NO.

67907 I 3 5 Chemical name Benzenesulfonic acid, 2(( 4(( 4((( 4 methyIphenyl) suifonyl) oxy) phenyl) azo) phenyl) amino) 5 nitro, monosodium salt 68958 98 5 70209 93 7 Benzenesulfonic acid, 3(( 4(( 4 hydroxyphenyl) azo) l naphthalenyi) azo), monosodium salt Benzoic acid, 2(( 8(( 4 chloro 6(( 4( 6 methyl 7 sulfo 2 benzothiazolyl) phenyl) amino) l ,3,5 triazin 2 yl) amino) I hydroxy 3,6 disulfo Z naphthalenyl) azo), tetrasodium salt 70209 98 z Benzenesulfonic acid, 2(( I( Z chloro 6 methylphenyl) 4,5 dihydro 3 methyl 5 oxo lH pyrazol 4 yl) azo) 4(( 4 chloro 6( phenylamino) l, 3.5 triazin 2 yl) amino), monosodium salt 70528 90 4 71735 65 4 3 Pyridinecarbonitrile, 5(( 4~ chloro 2 nitrophenyl) azo) l ethyl l ,2 dihydro 6 hydroxy 4 methyl 2 oxo

Tetrasodium( 8 hydro~ 7(( 2 hydroxy 7 sulpho 6(( 4(( 2,5,6 trichloro 4 pyrimidinyl) amino) phenyl) azo) 1 naphthyl) azo) naphthalene I ,3,6 trisulphonato( 6)) cuprate( 4)

72252 58 5 Chromate( 4), (mu( 3(( 2( amino kappaN)& (hydroxy kappaO) 6(( 2( hydroxy kappaO)& nitro 3 sulfophenyl) azo kappaN1) 7 sulfo l naphthalenyl) azo kappaN1) 2 hydroxy 5 sulfobenzoato( 8))) di, tetrasodium 72828 69 d Benzenesulfonic acid, 2(( 5 amino 3 methyl 1( 3 sulfophenyl) lH pyrazol 5 yl) azo), methylethylidene) di 4,1 phenylene) ester, disodium salt l, l'(( l

73309 47 4 78181 99 4 I Naphthalenesulfonic acid, 4,4'(( 4,6 dihydroxy l, 3 phenylene) bis( azo)) bis, disodium salt I Propanaminium, 3(( 2 cyano 3( 4( diethylamino) phenyl) l oxo 2 propenyl) oxy) N( 2(( 2 cyano 3( 4 (diethylamino) phenyl) l oxo 2 propenyl) oxy) ethyl) N. N dimethyi, chloride 85392 59 2 Iron, [. mu.[ 3[[ 5[[ 2,4 dihydroxy 5[( 2 hydroxy 3 nitro 5 sulfophenyl) dihydroxyphenyl) azo) 2 hydroxy 5 nitrobenzenesulfonato( 6))) di azo] phenyl) phenyl) methyl 2,4 112484 44 3 2,7 Naphthalenedisulfonic acid, 4 amino 6(( 4((( 4(( 2,4 diaminophenyl) azo) phenyl) phenyl) azo)% hydroxy 3(( 4 nitrophenyl) azo), potassium sodium salt amino) sulfonyl)

130201 55 7 Benzenesulfonic acid, 3,3'[[ 6( 4 morpholinyl) l, 3,5 triazine 2,4 diyl] bis[ imino[ 2( acetylamino) 4, l phen ylene] azo]] bis, disodium salt IV. Revisions to the TSCA Section 4( e) Priority Testing List 1. Benzme, 1,3,5 tri~ ror~ io 2( 2 popenylo. q+ i. Reco~ nme~~ dulion. Het~ ene. 1,3,5 tril~ rotno 2( 2~~ ro~ t~ 3~~~ ioxy) (CAS No, 3278~ W 5) is recommended to obtain unpublished exposure, environmetdal fte. health effects, snd ecological effects data. ii. Rutionnle /br ~~ ecommerrdotion. Benzene, 1,3,~ lril~ r. omo 2( 2 pro~ ettyloxy) is pradiclecl to persist and biocotlcentrate. There are vary few toxiaity data. Depending on the exposure, cmvironmental fate, health effecls, and ecological effects data that are provided. &he EPA mav consider hettzene. i, 3, s trihrotno 2( 2~ r,;~~~~ t~!~ ioxp) for their PB'1 Initiative. iii. Supporting ir~` om7fftAm. Hanasm, 1,3,5 tribromo 2( 2 proponyloxy] is produced in excess of 500,000 pounds pc> r annum and usad as a flame retardant for expanded polys? ymno insulation board. `The predicted HCF of benzene, 1,3,5 tribromo 2( 2 l~~ openyloxy) is 4,019. Tho rat oral LDSO was 5 grams/ kilograms (g/ kg) and it was not mutagenic in an Ames assay. A `IUXLINE search identified onto report that benzene, 1,3,5 tribrottto 2( 2 propenyloxy) was detected in sewer slime (Ref. 13). iv, Injimnation mwds. The ITC needs exposure, environmental f&. health effects. and ecological effects data. Only studies where henzone, 1,3,5 tribromo 2( 2 propenyloxy) is S 90% of the test substance by weight should be submitted. 2. I Triaeene, 1,3 di@ enyl i. I? econuncnd~ ftion. l Triazatis, 1,: 3 dipttenpl (diazoam~ lobenzet~ le) (MS No. 1X 35 6) is being rccotnmended to obtain amlual production/ importation volumes and trends.

use. exposure, and health effects data. ii. Rutionnle{ or mcmrrmzmd~ ztion. No occupational exposure limits have boon established by the American Confi? rence of Government Industrial H. ygionists (ACGIH). the National Institute for Occupational Safety and Health (NIOSH), or the Occupational Safety and Health Administration (OSHA). Occupational exposures have not been charecteriaed and there are no estitnatos of the number of workers exposed. The UC needs occupational exposure data from the uses of diazoaminohenzene, e. g., to tnanufacture dyes and insecticides. iii. Su~~~ orling in~ o~ fnc~ fion. A rec& t National Toxicology Program Report indicatecl that diazoaminobenzenc: is matabolizud in rats and tttice to the ktlowrt carcinogens benzene and aniiina (Ref. 12). Although not tested for carcinogcmicity, diazttatnittobotlzctnie is a predicted c: arcinogen l~ dsed on its mstdbolism and similarity in toxic effects to benzene and aniline. Diazoatttittobenzene is used as an intermediate, comploxing agent, and polymer additive. It is an itnpurity in certain color acldi tives used in cosmetics, food products. and pharmaoeuticals. It may alsa he used as a propellant for molding ofrubbt: rs and plastios and as a coupler to promote adhesion of natural rubber to steel tire cords. Sinoo tliazoatttittobenzette has scmic: onductittg properties it may have applir& ons in the semi cottcluctor indnslry. Diazoarninobonzene may put workers at a horetoforc: unrecognized increased risk of cancer if they are exposed in the workplace. `Importation, production, use. anct exposure information will assist in deterruining if diazoatttinobenzune tnay need further testing to adt? qwdle? lJ~ assess pOtC% ilid hazards associated with occupational exposures. iv. InJorrrMian needs. a. Recent non CBI estimates of aniiual production or imporlation volume data and trends. h. Use information, including peronntagcs of production or importation that are associated with different uses. c;. Estimates of the number of I. t~~ t~ atis atid concentrations of diazoaillirlobcnzsnt componttds to which humans may be exposed from use, manufacturing, or procnsstng. d. Health effects data including I'harntacokinetics, genotoxicity, suhchromic Federal Register/ Vol. 67, No. 146 /Tuesday, July 30, 2002 /Notices 49545 and chronic toxicity? reproductive, and 19. 1991) (FRL 39374). Acetone is being ethoxylates that were recommended in ITC's devdopmfmtal toxicity, and any hnnran clala from occupationally cjxposed workers. This removed from the Priorify Testing List 37f'a lTC Repm t [til FR ~IGG, February 2,

information is needed in order to adequately bncause it was in the OK11 SWS program 19961 (E'KL MSI Ci), 3YU~ 1'K Repor (02 FK access thn extent and degree of exposure and (see llttp:// irptc. unep. ch/ irp~ c/ sidsl 0578. Fabruary 25,1997) (ML 5580~ 9), and potential hazard associated with sidspubhh~ l volume 6) and because it is 41% ' 1'1'c Report (63 FR 17658 , April 9.1998)

diaeoarrlirlobellzene. included in the EPA's VCCEP for (FRL 5773 S). At this time, the ITC is c. Only studies where diazoarninobenzslle reproductive effects and developmental ronloving from the Priority Testing Lisf. 9 is >90% of the test substance by weight toxicity testing (htlp: llcvwM~. epa. gov/ alkylphenols and alkylphenol ethoxylates should be submiltnd. ct~ emrtk/ cl~ ildhl~.~~ tn~). The EPA anticipates hXll ih0 3TnL ITC k?[ JWt, 7 llfXlyl~ Jh?~ d that under the! VCCEP, tier 2 testing for ethoxylatos from the 39 lTC Report, aud 4 B. Chw1icrrl. s lbmoved From ths Priority prfm. t~ al developmental toxicity, alkylphenols and alkylphenol cthoxylatos Testing List reproductive and fertility affects testing will from the 41~ 1 ITC Report (soo Table 5 of this 1, Af: cfr> nC!. Act? QJne was designated in the ho conducted for acetone. appendix). `The rationales for removing these ITC's 28'" ITC Report for reproductive affects Z. Twmty nlkylphcnols and nlkylphcnol alkglphm~ ols and alkylphonol ethoxylatos s. r~ testing as a chemical with a low confidence cthoxylalcw. `f? lt! lTC is continuing to review provided as fflolnotes Lo Table 5 of this refeerencc dose or KfL1 (ae FK 41212. August data on the alkylphenols and alkylphenol appendix.

TABLE 5. ALKYLPHENOLS AND ALKYLPHENOL ETHOXYLATES BEING REMOVED FROM THE PRIORITY TESTING LIST Report CAS No. Chemical name Rationale 37 99 71 8 I set Butyiphenol 1 37 104 40 5 4. Nonylphenol 2 37 1638 22 a 4 n Butylphenol 2 37 9002 93 I Polyethylene glycol 4( tert octyl) phenyl ether 2 37 9038 19 5 Polyethylene glycol mono( octyl) phenyl ether 3 37 14938 35 3 4 Pentylphenol 2 37 27193 28 8 (1,1,3,3 TetramethylbutyI) phenol (mixed isomers) 3 37 27193 86 8 Dodecylphenol (mixed isomers) 4 37 68987 90 6 Poly( oxy l, 2 ethanediyl), *alpha.( octylphenyl). omega. hydroxy, branched 3 39 20427 84 3 2[ 2( 4 Nonyiphenoxy) efhoxy] ethanol 2 39 37205 87 I Poly( oxy 1,2 ethanediyl), .alpha.( isononylphenyl). omega. hydroxy 2 39 68412 54 4 Poly( oxy 1,2 ethanediyl), .alpha.( nonylphenyl). omega. hydroxy, branched 2 39 98113 10 t NP 9 2 39 127087 87 o Poly( oxy 1,2 ethanediyl), .alpha.( 4 nonylphenyl)< omega. hydroxy, branched 2 39 9016 45 g Poly( oxy 1,2 ethanediyl), .alpha.( nonylphenyl). omega. hydroxy 5 39 26027 38 3 Poly( oxy 1,2 ethanediyl), .alpha.( rl nonylphenyl). omega. hydroxy 5 41 74499 35 7 Phenol, (tetrapropenyl) derivs. 4 41 68908 55 4 Phenol, polybutene derivs. 2 41 112375 88 9 Phenol, polyisobutylene derivs. 2 41 9014 92 O Poly( oxy l, 2 ethanediyl), tc( dodecylphenyl)"~ hydroxy 2 Removal rationales: 1. Data developed from testing 4 tert butylphenol (CAS No. 98 54 4) in response to the HPV Challenge program may be used to predict tox icity. 2. No domestic production or importation volumes were reported to the EPA in response to 1986, 1990, 1994, and 1998 IURs or no domestic production or importation volumes were reported to the EPA in response to the July 5, 2000 PAIR rule (65 FR 41371) (FRL 6589 1). 3. Data developed from testing phenol, 4( 1,1,3,3 tetramethylbutyI) (CAS No. 140 66 g) in response to the HPV Challenge program may be used to predict toxicity. 4. Data developed from testing p dodecylphenol (CAS No. 210555 94 5) in response to the HPV Challenge program may be used to predict toxicity. 5. Data developed from testing branched nonylphenol (CAS No. 84852 153) in response to the HPV Challenge program may be used to pre dict toxicity.

Them are 10 alkylphonols and alkylphenol uthoxylates remainin:: on the Priorify Testing List (sea Table 6 of this appendix]. 49546 Federal Register / Vol. 67, No. 148 /Tuesday, July 30, 2002 /Notices TABLE 6. ALKYLPHEN~ L~ AND ALKYLPHENOL ETHOXY~ ATES REMAINING 0~ THE PRIORITY TESTING LIST 37 Report CAS No. Chemical name 80 48 6 4 tert Pentylphenol 37 88 l 8 8 2 tert Butylphenol 37 98 54 4 4 tert Butylphenol I 37 / 1806 26 4 1 4 Octylphenol 37 I 25154 52 3 Nonylphenol (mixed isomers)

I 37 1 84852 15 3 1 Branched nonylphenol (mixed isomers)

39 27986 36 3 2( Nonylphenoxyl) ethanol 41 1987 50 4 Phenol, rl heptyl

41 72624 02 3 Phenol, heptyl derivs.

41 140 66 g Phenol, 4( 1 ,I ,3,3 tetramethylbutyl)

3. Thrcx DlilWS chemicals jkxn the, 4h'lf1 ITC Report. In its 461" lTC Report, the ITC discussed 2 groups of DEBl'iS chemicals, polychloropflellois and pol? rchlorobenzent: thiols and chlorotdfl~ torolIlc~ thyipl~ enoxy benzenes (85 FK75552. Decerhx 1, ZOOO) @XL 6594 7). Two of the polychlorophsnols and polychloroballzonothiols [pentacl~ lorotMoI~ henol, CAS No. 133 49 3 and tetrachloropyrocate~ hol, CM No. 119% ~ 6) and two of the chlort) trifluorometllylphen~~ xy bsrtzenes (p toluidine, 5 chloro. alpha... alpha.,. alpha. trifluoro 2 niho N phenyl. CM No. 180B 24 2 and benzoic acid, 3[ 2 chloro 4 (trifluoromf: thyl] pl~ enoxy], 2 ethoxy l mo~ hyl 2 oxo, CAS No. 88185 22 2) were subsequently added to the I+ iori$ Testing List in the 1TC's 471" ITC Report. All 4 of .these chemicals were added to the July 26, 2001 PAIKruie( liG FK 38955)( E'fCL 6783 R). All of those chemicals, except porltachlorclthioph1~ nol, are being removed from tile Priority Testi17g List because 1x3 production or importation data were submitted to the EPA in response to tho 1998 IUR (10,000 pound reporting threshold) or tilt? Tulv 26, 2001 PAIK rule (1,000 klound rep& t&~ tl& shold). 4. Three DEBITS chemicds from the 47fI' 1'l'CAeport. In its 47'" UC Report, the ITC added 3 chloroalkenes to the Priority Y'esling List: 1,3 butadiene, 1., 1.2,3,4 pentachloro 4 (1 methylolhoxy) (CM No. 6833~ G7 8); 3 butenoic acid. 2,2,3.4,4 peiltachloro butyl ester (CM No. 75147 20 9); and 3 butenoic acid, 2,2,:~, 4,4pentar: hloro (CM No. 85743 61 9). The ITC is removing these 3 chloroalkenos from the Priority ?` esGng List because no production or importation data were submitted to the WA in respnnso to the 1998 IUR. 8. Nine DEBITS cl~ enticals from the 4Hl" 1X lieport. 1x1 its 48'" ITC Report. the ITC added 5 chlorinated trihalomethyl pyridines, 2 trihaloethyliden~ bisbenzanes, 4 tricl~ lorophnnyldi~ dropyrazols and 3 chloro 2,6; dinitro N? N tlipropyl 4 (trifluoromethyl] benzenoamine to the IWority Teslirzg List. `The ITC is removing the the trihaloathylidone bisboizctnes (benzene, 5 chlorinated trihalomethyl pyridinos, 1 of 1, x'( 2,2,2 trichloroothylidene) bis), and 3 of the trichlorophenvldihydropyrazols (benzamide, 3 aul: lno N[ 4.5 dihgdro, 5 oxo l (2,4,8 tri~~~ loroph~~~~~ l) 1H pMriiaoll; 3H l).\` razol 3 one, 5(( 5~ amino 2 chlorophenpl) alnino) 2,4 dihydro a( 2,4,6 trichlorophsnyl); and benzamide, N( 4,5 dihydro+ oxo l (2,4, B lt. ichloroI~ ht~ llyl) 1H pyrazol 3 yl) 3 iiilo) from the Eoriiy Testing Lisf hecause no productioii or importation dsta wem submitted to the EPA in response to the 1998 IUR or because tlw predicted BCFs were judged lo be loo low to warrant priority consideration al this time.

V. References Register (45 FR 35897 35910, May 2H, 1980). Priority ?bsting List of Chemicals. Federal 6. ITC. 1980b. Seventh Report of the TSCA Interagency `Testing Committee (October 24, 1980) to the Administrator; Receipt of Report and Request for Comments Regarding the f'rjority Tcxting fist of Chemicals. Federal Register (45 FR 78432 78440, Novembt: r 25, 1980). 7. ITC. 1982. Eluwdh Report of the TSCA Interagency `Tesling Cormnittee (November 3, 1982) lo the Administrator: Receipt of Report and Request for Corrmienls Kogarding I+ ior?` fy Testjng Lis/ of Chornicals. Federal Register (47 E'K 54625 54044. L) aixxb3r 3, 1982). 8. ITC. 1984. Foubeenth Report of the `TSCA Interagencv Testing Committee (May 8, 1984) to the Adn; inistrator; Receipt of Report and Request for Comments Regarding Eority T& in:: List of Chemicals. Federal Register (49FR223W22407, h'fay29,1984). 1. lTC. 1977. Initial Report of the TSCA Interagency Testing Committee (October 1, 1977) to the Administrator: Rocoipt of Report and Request for Commc~~ ts Regarding the fXori! y `I% stin$ List of Chemicals. Federal Register (42 FK 55026 55080. October 12. 1977). 2. KC. 197th Second Kf! port 0I the `TSCA Inleragency Testing Committee (April 10, 1978) lo the Administrator; Receipt of Report md Request for Comments Regarding the Priority Testing Lisl of Chemicals. Federal Register (43 PR 16684 10R88, April 19, 1978). 3. ITC. l97Ub. Third Report of the TSCR Interagency Tosting Committee (October 2, 1978) to the Administrator; Receipt of Report and Request for Comments Regarding the I'riorjtJ/ Tesfing List of Chemicals. Federal Regisler (43 FR 50630 50635, October 10, 1978). 4. ITC. 1979. Fifth Report of the TSCA Interagency Testing Committee (November 8, 1979) to the Administrator; Receipt of Report and Request for Comments Regarding the I'riorify `I% sting List of Chemicals. Federal Register (44 FII 70604 7~ 74, December 7, 1979). 5. ITC. 1980a. Sixth Report of the TSCh Interagency Testing Committee (April 9, 1980) to the Administrator; Receipt of Report a~ ld Nequest for Comments Regarding thu 9, ITC. 1985. Sixteenth Report of the TSCA interagency Testing commiltea (May 2, lSU. i) to the Administrator: Receipt of Kepofi ad Request for Comments Regarding I'riorily Tes@ List of Chemicais. Federal Register (60 FK 2093040939, May 21.1985). 10. 1'X. 1986. Ninetemth Report of tht! `I'SCA Interagency Testing Committee (October 3 1, 198( S) to the Administrator: Receipt of Report and Request for Comments Regarding priority Testing List of Chemicals. FederalRegister (51 FR41417 41432, November 14, 1986). 11. 1TC. 1989. Twenty Bftb Roport of the TSCA Interag: ency Testing Committee (November 1, 1989) lo the Administrator; Xoceipt of Report and Request for Comments Regarding Priority Tes/ jng Lisl. of Chemicals. Federal Kegister (54 FR 51114 51130, Decembsr 12, 1989). 12. National Toxicologv Program (NTI'). 2002. Toxicity Report Se& es Number 73. NW report on the metabolism, toxicity, and predicted carcinogenicity of diazoaminoborr~ ene (CAS No. 136 35 6). U. S. Department of Health and Human Services, Public Health Service, Natiorral institutes of Health. NIH Publication No. Ol 4412. Draft abstract available online at: http:/ Federal Register /Vol. 67, NO. 146 /Tuesday, July 30, 2002 /Notices 49547 13. Sauer J., Antnsch E., and l?. i). m C. 1997. Mflnitoring bf organic pollutants i;; sewer systems by sewer slime analysis. pp. 49 69. In Haberor K (ad.) Wutcr. VCH Publishers, Inc,. New York. NY. ISBN 3 527 28820 l. 14. Walker JD. 1993. The TSCA Intttragency Testing Commitlue, 1977 lo 1992: Creation,

451 509. In J. W. Gorsuch, F. J. Dwycr, d6. Ingersoll and T. W. La Pointe (cds.), Environmentul Tosicolo~~ and Hisk Assossnlef~ l: Second v011me, AS'l? vf F m 1216. ASTM, Philadelphia, PA.

Vl. TSCA I~~ teragency Testing Committee Statutory Organizations and Their Representatives Council on Envfronmentul Quulity Vacant Department a/ ' Cummerce A'ofionul Inslit~ le of Stnndards rind Teclmoloav <,., Robert Huie, Membor Barbara C. Lsvin, Alternate Atmospheric Administratk~ Thomas P. O'Con~ ior, Member Tari Rowles, Allernale Environmental Pratsction Agency Paul Camuanella, Member David R. %illiams, Alternate Nutianal Cancerlnstitule Barbara Lucom, Member Alan Poland, Member Kenneth Still, Alternate David Longfellow, Alternate Josi Centsno, Alternate Dopallxnsnl of the Inferior Harnett A. Rattner, Member Scott Maston, Member, Chair William Eastin. Allsrndle Nutional InsMute Jor Occupational SuJety and Henllh Mark Toraason, Member, Vice Chair Dennis W. Lynch, Alternate Nutionul Science Faundutian A. Frederick `Ihompson, Mmnber Marge Cavanaugh, Alternate Occuwatianal Safetv and Health Admin& r* tian ' . Val I I. Schaeffer, :Member Lyn Psnniman, Alternate Liaison Organizalirms and Their Representatives Agency Jar Toxic Substances and Disease Ilegistry William Cibulas, Member Daphne Moffett, Altttrnate Consumer Product Suj& ty Commission lacquelino Parrante, Member `Treye Thomas. Alternate Depurtment of Agriculture Clifford P. Rice, Member Laurau L. McConnell, Allornate DepartmerLt oJ DeJkst? Food and Drug Administra tian David Hatlen. A1tarnale A~ ational Lilxcu y o J& fcNcinr: Vera W. Hudson. Member C011nse1 Scott Sherlock, OPI'T, EPA Ikchnical sqaport Cont1nctcJr Syrat: uso Research Corporation ITC stuff John D. Walker, Exxecutivc Director Norma S. L. Williams, Bxccl~ tive Assistant `I'SCA interagency Testing Committee, Office of Pollution Prevention and Toxics (74OlM), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., WashingIon, DC 20460; telephone number: (202) 584 7527; fax number: (202) 564 7828; e mail address: willi~ ms. normaQopa. gov; url: http:// www. apa. govlopptintr/ ilc.

IDRDoc. 02 19230 Filed 7 29 02; 8: 45 am]

BILLING CODE 6560 50 S