DRAFT AGENDA

FIFRA SCIENTIFIC ADVISORY PANEL (SAP)

	OPEN MEETING

October 6 – 9, 2009

FIFRA SAP WEB SITE http://www.epa.gov/scipoly/sap/

OPP Docket Telephone:<PHONE_NUMBER>

Docket Number: EPA-HQ- OPP-2009-0516

U.S. Environmental Protection Agency

Conference Center - Lobby Level

One Potomac Yard (South Bldg.)

2777 S. Crystal Drive, Arlington, VA 22202

Evaluation of Updated Standard Operating Procedures for Residential
Pesticide Exposure Assessment

Please note that all times are approximate

(See note at the end of the Agenda)

Tuesday, October 6, 2009

8:30 A.M.	Opening of Meeting and Administrative Procedures by Designated
Federal Official – Myrta R. Christian, M.S., Designated Federal
Official, Office of Science Coordination and Policy, EPA

8:35 A.M.	Introduction and Identification of Panel Members - Steven G.
Heeringa, Ph.D., FIFRA Scientific Advisory Panel Chair

8:45 A.M.	Welcome – Debbie Edwards, PhD., Director, Office of
Pesticide Programs, EPA

8:50 A.M.	Welcome and Opening Remarks – TBD, Health Effects Division,
Office of Pesticide Programs, EPA

9:00 A.M.	Goals and Objectives – TBD, Health Effects Division, Office
of Pesticide Programs, EPA

9:15 A.M	Overview of Residential Pesticide Exposure Assessment – TBD,
Health Effects Division, Office of Pesticide Programs. EPA

10:15 A.M.	Break

10:30 A.M.	Residential Handler Exposure Assessment – TBD, Health
Effects Division, Office of Pesticide Programs, EPA

11:15 A.M.	Residential Post-application Dermal Exposure Assessment –
TBD, Health Effects Division, Office of Pesticide Programs, EPA

12:00 P.M.	Lunch

1:00 P.M. 	Residential Post-application Inhalation Exposure Assessment
– TBD, Health Effects Division, Office of Pesticide Programs

1:45 P.M.	Residential Non-dietary Ingestion Post-application Exposure
Assessment – TBD, Health Effects Division, Office of Pesticide
Programs, EPA

2:30 P.M.	Residential Aggregate Exposure Assessment – TBD, Health
Effects Division, Office of Pesticide Programs, EPA

3:00 P.M.	Break

3:15 P.M.	Lawns and Turf – TBD, Health Effects Division, Office of
Research and Development, EPA

3:45 P.M.	Gardens and Trees – TBD, Health Effects Division, Office of
Pesticide Programs, EPA

4:15 P.M.	Insect Repellents – TBD, Health Effects Division, Office of
Pesticide Programs, EPA

5:00 P.M.	Adjourn

DRAFT AGENDA

FIFRA SCIENTIFIC ADVISORY PANEL (SAP)

	OPEN MEETING

October 6 – 9, 2009

FIFRA SAP WEB SITE http://www.epa.gov/scipoly/sap/

OPP Docket Telephone:<PHONE_NUMBER>

Docket Number: EPA-HQ- OPP-2009-0516

U.S. Environmental Protection Agency

Conference Center - Lobby Level

One Potomac Yard (South Bldg.)

2777 S. Crystal Drive, Arlington, VA 22202

Evaluation of Updated Standard Operating Procedures for Residential
Pesticide Exposure Assessment

Wednesday, October 7, 2009

8:30 A.M.	Opening of Meeting - Administrative Procedures by Designated
Federal Official - Myrta R. Christian, Designated Federal Official,
Office of Science Coordination and Policy, EPA

8:35 A.M.	Introduction and Identification of Panel Members -

		Steven G. Heeringa, Ph.D., FIFRA Scientific Advisory Panel Chair

8:50 A.M.	Questions/Clarifications – TBD, Health Effects Division, EPA

9:00 A.M.	Outdoor Fogging/Misting Systems – TBD, Health Effects
Division, Office of Pesticide Programs, EPA

9:30 A.M.	Indoor Environments – TBD, Health Effects Division, Office
of Pesticide Programs, EPA

10:00 A.M	Break

10:15 A.M.	Treated Pets – TBD, Health Effects Division, EPA

10:45 P.M.	Impregnated Materials – TBD, Health Effects Division, EPA

11:15 P.M.	Paints and Wood Preservatives – TBD, Health Effects
Division, EPA

12:00 P.M.	Lunch

1:00 P.M.	Public Comment

3:00 P.M.	Break

3:15 P.M.	Charge to the Panel - Question 1

Exposure Sources, Routes, and Populations of Concern

The scope of this effort by the Agency has been to focus on revising its
methods for conducting exposure assessments for the most commonly
available products which, through various routes (i.e., dermal,
inhalation, etc.), may lead to exposure in the home or otherwise in the
general population.  For example, pet uses, lawn care, insect
repellents, and indoor pest control are common exposure sources and
dermal, inhalation, and non-dietary ingestion through mouthing behavior
are common exposure routes.  A constant challenge in the completion of
exposure assessments associated with the residential uses of pesticides
is ensuring that they are reflective of the current marketplace which
rapidly evolves to provide the latest conveniences to consumers.  The
advent of monthly flea control spot application products is one example
of market forces and technology altering the way pesticides are used in
and around the home.  These revisions have been primarily based on the
availability of recent data received from various pesticide registrants
as well as other public and private data.  The Agency is aware that
there are other residential exposure sources for which assessments have
been conducted in the past (e.g., field volatilization and mosquito
control applications), but which have not been included in this current
effort.  While future revisions will focus on methodologies for the
aforementioned exposure sources, the use patterns included in the
document are the focus of this FIFRA SAP meeting.

Additionally, as a standard routine pesticide exposure assessment
practice, the Agency uses select age-based life stages (referred to as
“sentinel populations”) considered the most highly exposed for each
scenario as a means to encompass exposures and risks for all potentially
exposed age groups.  This is done mainly to streamline the exposure and
risk assessment process and save time and resources, but also as a
reflection of the limitations of our data.  For example, though based on
limited data, observational studies appear to indicate that infants
exhibit higher mouthing behavior than toddlers.  However, toddlers may
be the chosen sentinel population for non-dietary exposure assessments
in certain scenarios because they spend a longer amount of time doing
certain activities that contribute to greater overall exposure levels.
This behavioral difference results in a greater potential to contact
surface residues and thus a greater potential for exposure.

Please comment on the completeness of both the exposure sources and
exposure routes identified for each scenario.  If a type of product or a
potential source of exposure has not been identified, please identify
them and suggest modifications to ensure that they are reflected in the
SOP document.

Please comment on whether the sentinel population approach is reasonable
for exposure assessment purposes and on the age-based choices for each
scenario.

5:00 P.M.	Adjournment

DRAFT AGENDA

FIFRA SCIENTIFIC ADVISORY PANEL (SAP)

	OPEN MEETING

October 6 – 9, 2009

FIFRA SAP WEB SITE http://www.epa.gov/scipoly/sap/

OPP Docket Telephone:<PHONE_NUMBER>

Docket Number: EPA-HQ- OPP-2009-0516

U.S. Environmental Protection Agency

Conference Center - Lobby Level

One Potomac Yard (South Bldg.)

2777 S. Crystal Drive, Arlington, VA 22202

Evaluation of Updated Standard Operating Procedures for Residential
Pesticide Exposure Assessment

Thursday, October 8, 2009

8:30 A.M.	Opening of Meeting - Administrative Procedures by Designated
Federal Official - Myrta R. Christian, Designated Federal Official,
Office of Science Coordination and Policy, EPA

8:35 A.M.	Introduction and Identification of Panel Members -

		Steven G. Heeringa, Ph.D., FIFRA Scientific Advisory Panel Chair

8:50 A.M.	Questions/Clarifications – TBD, Health Effects Division,
Office of Pesticide Programs, EPA

9:15 A.M.	Charge to Panel – Question 2

Utility and Transparency of the Residential SOPs

Two primary goals of the Residential SOPs are 1) to serve as an
instruction manual for residential pesticide exposure assessors, and 2)
provide transparency to stakeholders who wish to understand how the
Agency conducts residential pesticide exposure assessments.

Please comment on whether the Residential SOPs meet these goals, and if
not, identify where improvements are needed.

10:30 A.M.	Break

10:45 A.M.	Charge to Panel - Question 3

Consideration of Data Sources

The Agency has attempted to comprehensively identify sources of
applicable data for use in revising the Residential SOPs by evaluating
exposure assessment literature, studies generated by pesticide
registrants, survey research, and data provided in peer reviewed Agency
publications such as the Exposure Factors Handbook, the Child-Specific
Exposure Factors Handbook, and Guidance on Selecting Age Groups for
Monitoring and Assessing Childhood Exposures to Environmental
Contaminants.

Please comment on the strengths and limitations of the data sources
identified by the Agency, including the implications of associated study
designs, and how these factors might impact their use in exposure
assessment.

Please comment on whether additional data are available and how they
might be incorporated into the document.

12:00 P.M.	Lunch

1:30 P.M.	Charge to Panel – Question 4

Analysis and Utilization of Available Data

The Agency has summarized and presented the data analysis for all
exposure factors.  Examples include the analysis of transferable
residues indoors, and on lawns, garden plants, and pets; analysis of
post-application exposure studies for the purposes of developing
transfer coefficients for children playing on lawns, homeowner
gardening, and contacting pets; and analysis of insect repellent
efficacy studies to establish formulation-specific application rates.
Additionally, where data are lacking and surrogate data have been
proposed or data are unavailable and expert judgment is applied, the
Agency has attempted to explain the rationale behind its choices.
Examples include “time spent outdoors playing” as a surrogate for
time spent on lawns, “time spent outdoors at a farm” as a surrogate
for time spent at a “pick-your-own” farm, and assumptions for spray
volumes for residential handlers.

Please comment on whether the various data analyses and data choices for
each scenario are scientifically sound and reasonable for the purposes
of residential pesticide exposure assessment.  Please include commentary
on the analysis and use of:

exposure data for developing pet activity dermal transfer coefficients;

scenario-specific data used to estimate surface-to-hand residue transfer
for non-dietary ingestion exposure assessments;

repellent application data to establish formulation-specific rates;

occupational re-entry exposure data to establish dermal transfer
coefficients for home gardening and ornamental maintenance; and,

data supporting differentiation between potential exposures following
indoor broadcast treatments and localized “crack-and-crevice”
treatments.

Please identify specific examples and recommendations for analytical
modifications or any additional data that may enhance or supplement
those presented in the SOPs.

3:00 P.M.	Break

3:15 P.M.	Charge to Panel – Question 5

Residential Exposure Assessment Methodologies and Algorithms

Most of the residential exposure scenarios use algorithms that employ
chemical- and scenario-specific exposure monitoring data coupled with
applicable exposure factors to predict exposures.  They are common
approaches for pesticide exposure assessment and consistent with the
Agency’s Guidelines for Exposure Assessment with some being included
in recent SAP discussions.  Examples include the use of applicator
exposure monitoring data for various chemicals and scenarios to derive
the unit exposure-based residential handler exposure algorithm (January
2007 SAP), the use of post-application exposure monitoring data for
various chemicals and scenarios to derive the transfer coefficient-based
post-application dermal exposure assessment (December 2008 SAP), and the
non-dietary ingestion exposure model (August 2005 and August 2007 SAP).
Other scenarios, like post-application inhalation exposure following
indoor and outdoor fogger applications, now rely more heavily on
standard 1st principles modeling to predict exposures, which tend to
require less case-specific data.  There are also some scenarios, like
insect repellents and dust ingestion indoors, that are new additions to
the Residential SOPs whose methodologies will benefit from SAP review.

Please comment on whether the methodologies and algorithms for each
scenario used are scientifically sound and reasonable for the purposes
of these SOPs.  Please include commentary on:

scenario-specific approaches for both hand-to-mouth and object-to-mouth
non-dietary ingestion exposure;

post-application inhalation exposure (e.g., the well-mixed box model);
and,

considerations for assessing exposure via ingestion of dust.

Please identify specific examples and provide recommendations for
improvement or alternative approaches.

5:00 P.M.	Adjournment

DRAFT AGENDA

FIFRA SCIENTIFIC ADVISORY PANEL (SAP)

	OPEN MEETING

October 6 – 9, 2009

FIFRA SAP WEB SITE http://www.epa.gov/scipoly/sap/

OPP Docket Telephone:<PHONE_NUMBER>

Docket Number: EPA-HQ- OPP-2009-0516

U.S. Environmental Protection Agency

Conference Center - Lobby Level

One Potomac Yard (South Bldg.)

2777 S. Crystal Drive, Arlington, VA 22202

Evaluation of Updated Standard Operating Procedures for Residential
Pesticide Exposure Assessment

Please note that all times are approximate (see note at end of Agenda).

Friday, October 9, 2009

8:30 A.M.	Opening of Meeting - Administrative Procedures by Designated
Federal Official - Myrta R. Christian, Designated Federal Official,
Office of Science Coordination and Policy, EPA

8:35 A.M.	Introduction and Identification of Panel Members -

		Steven G. Heeringa, Ph.D., FIFRA Scientific Advisory Panel Chair

8:50 A.M. 	Follow-up from Previous Day’s Discussion – TBD, Health
Effects Division, Office of Pesticide Programs, EPA

9:15 A.M.	Charge to Panel – Continuation of Previous Day’s

11:30 A.M.	Adjournment

Please be advised that agenda times are approximate; when the discussion
for one topic is completed, discussions for the next topic will begin.
For further information, please contact the Designated Federal Official
for this meeting, Myrta R. Christian, via telephone:<PHONE_NUMBER>;
fax:<PHONE_NUMBER>; or email<EMAIL_ADDRESS>
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