[Federal Register Volume 85, Number 156 (Wednesday, August 12, 2020)]
[Notices]
[Pages 48685-48686]
[FR Doc No: 2020-17612]

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DEPARTMENT OF ENERGY

Federal Energy Regulatory Commission

Combined Notice of Filings #1

    Take notice that the Commission received the following electric
corporate filings:

    Docket Numbers: EC20-87-000.
    Applicants: Rippey Wind Energy LLC.
    Description: Application for Authorization Under Section 203 of the
Federal Power Act, et al. of Rippey Wind Energy LLC.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5085.
    Comments Due: 5 p.m. ET 8/26/20.

    Take notice that the Commission received the following exempt
wholesale generator filings:

    Docket Numbers: EG20-225-000.
    Applicants: Hardin Solar Holdings LLC.
    Description: Notice of Self-Certification of Exempt Wholesale
Generator Status of Hardin Solar Holdings LLC.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5049.
    Comments Due: 5 p.m. ET 8/26/20.

    Take notice that the Commission received the following electric
rate filings:

    Docket Numbers: ER19-2856-001.
    Applicants: Birchwood Power Partners, L.P.
    Description: Report Filing: Refund Report to be effective N/A.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5052.
    Comments Due: 5 p.m. ET 8/26/20.

    Docket Numbers: ER20-2402-001.
    Applicants: PJM Interconnection, L.L.C.
    Description: Tariff Amendment: Supplement to Original ISA, SA No.
5682; Queue Nos. AF1-190/AF1-191 to be effective 6/11/2020.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5103.
    Comments Due: 5 p.m. ET 8/26/20.

    Docket Numbers: ER20-2607-000.
    Applicants: New England Power Company.
    Description: Compliance filing: Order No. 864 Compliance Filing Re
Seabrook Transmission Support Agreement to be effective 1/27/2020.
    Filed Date: 8/4/20.
    Accession Number: 20200804-5240.
    Comments Due: 5 p.m. ET 8/25/20.
    Docket Numbers: ER20-2608-000.
    Applicants: Public Service Company of New Hampshire.
    Description: Compliance filing: Order No. 864 Compliance Filing,
RM19-5 to be effective 1/27/2020.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5006.
    Comments Due: 5 p.m. ET 8/26/20.

    Docket Numbers: ER20-2609-000.
    Applicants: NSTAR Electric Company.
    Description: Compliance filing: Order No. 864 Compliance Filing,
RM19-5 to be effective 1/27/2020.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5008.
    Comments Due: 5 p.m. ET 8/26/20.
    Docket Numbers: ER20-2610-000.
    Applicants: The Connecticut Light and Power Company.
    Description: Compliance filing: Order No. 864 Compliance Filing,
RM19-5 to be effective 1/27/2020.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5009.
    Comments Due: 5 p.m. ET 8/26/20.

    Docket Numbers: ER20-2611-000.
    Applicants: Southwest Power Pool, Inc.
    Description: Sec.  205(d) Rate Filing: 3723 Southwestern Power
Admin & WFEC

Interconnection Agr to be effective 8/1/2020.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5010.
    Comments Due: 5 p.m. ET 8/26/20.

    Docket Numbers: ER20-2612-000.
    Applicants: Hardin Solar Holdings LLC.
    Description: Baseline eTariff Filing: Application for Market-Based
Rate Authorization to be effective 8/24/2020.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5070.
    Comments Due: 5 p.m. ET 8/26/20.

    Docket Numbers: ER20-2613-000.
    Applicants: Midcontinent Independent System Operator, Inc.
    Description: Sec.  205(d) Rate Filing: 2020-08-05_SA 3243 Deuel
Harvest Wind-OTP 1st Rev GIA (J526) to be effective 7/22/2020.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5072.
    Comments Due: 5 p.m. ET 8/26/20.

    Docket Numbers: ER20-2614-000.
    Applicants: New England Power Company.
    Description: Compliance filing: Order No. 864 Compliance Filing Re
New England Power AC Support Agreement to be effective 1/27/2020.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5053.
    Comments Due: 5 p.m. ET 8/26/20.

    Docket Numbers: ER20-2615-000.
    Applicants: Tri-State Generation and Transmission Association, Inc.
    Description: Sec.  205(d) Rate Filing: Rate Schedule FERC No. 280
between Tri-State and Wheatland to be effective 8/6/2020.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5130.
    Comments Due: 5 p.m. ET 8/26/20.

    Docket Numbers: ER20-2616-000.
    Applicants: Public Service Company of Colorado.
    Description: Sec.  205(d) Rate Filing: PSCo-TSGT-UPI-Rev. Const,
O&M-Fairgrounds SS-318-0.1.0 to be effective 8/6/2020.
    Filed Date: 8/5/20.
    Accession Number: 20200805-5133.
    Comments Due: 5 p.m. ET 8/26/20.

    The filings are accessible in the Commission's eLibrary system
(https://elibrary.ferc.gov/idmws/search/fercgensearch.asp) by querying
the docket number.
    Any person desiring to intervene or protest in any of the above
proceedings must file in accordance with Rules 211 and 214 of the
Commission's Regulations (18 CFR 385.211 and 385.214) on or before 5:00
p.m. Eastern time on the specified comment date. Protests may be
considered, but intervention is necessary to become a party to the
proceeding.
    eFiling is encouraged. More detailed information relating to filing
requirements, interventions, protests, service, and qualifying
facilities filings can be found at: http://www.ferc.gov/docs-filing/efiling/filing-req.pdf. For other information, call<PHONE_NUMBER>
(toll free). For TTY, call<PHONE_NUMBER>.

    Dated: August 5, 2020.
Nathaniel J. Davis, Sr.,
Deputy Secretary.
[FR Doc. 2020-17612 Filed 8-11-20; 8:45 am]
BILLING CODE 6717-01-P


[Federal Register: July 31, 2008 (Volume 73, Number 148)]
[Notices]
[Page 44712-44715]
[DOCID:fr31jy08-37]

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DEPARTMENT OF ENERGY

Federal Energy Regulatory Commission

Combined Notice of Filings 1

July 23, 2008.
    Take notice that the Commission received the following electric
corporate filings:

    Docket Numbers: EC08-112-000.
    Applicants: Brush Cogeneration Partners, Ripon Cogeneration, LLC,
Fort Chicago Power Colorado LLC.
    Description: Brush Cogeneration Partners et al. submits an
application for authorization for disposition of jurisdictional
facilities and request for expedited action.
    Filed Date: 07/17/2008.
    Accession Number: 20080718-0203.
    Comment Date: 5 p.m. Eastern Time on Thursday, August 07, 2008.

    Docket Numbers: EC08-113-000.
    Applicants: Brush Cogeneration Partners.
    Description: Brush Cogeneration Partners submits Application for
Authorization under section 203 of the Federal Power Act for
Disposition of Jurisdictional Facilities and Request for Expedited
Action.
    Filed Date: 07/17/2008.
    Accession Number: 20080718-0201.
    Comment Date: 5 p.m. Eastern Time on Thursday, August 7, 2008.

    Take notice that the Commission received the following exempt
wholesale generator filings:

    Docket Numbers: EG08-81-000.
    Applicants: Sherbino I Wind Farm LLC.
    Description: Notice of Self-Certification as an Exempt Wholesale
Generator of Sherbino I Wind Farm LLC.
    Filed Date: 07/17/2008.
    Accession Number: 20080717-5116.
    Comment Date: 5 p.m. Eastern Time on Thursday, August 7, 2008.

    Take notice that the Commission received the following electric
rate filings:

    Docket Numbers: ER99-4122-028; ER99-4124-024; ER07-428-006.
    Applicants: Arizona Public Service Company, PINNACLE WEST MARKETING
& TRADING CO, LL, APS Energy Services Company.
    Description: Notices of change in status.
    Filed Date: 07/14/2008.
    Accession Number: 20080714-5072.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER00-1952-007; ER01-1784-010; ER99-1248-009; ER08-
333-003; ER03-222-009; ER08-851-002.
    Applicants: Black Hills Colorado, LLC; Fountain Valley Power, LLC;
Harbor Cogeneration Company, LLC; Las Vegas Cogeneration LP; Las Vegas
Cogeneration II, LLC; Valencia Power, LLC.
    Description: Black Hills Colorado, LLC et al. notifies FERC of a
non-material change in status with respect to the market-based rate
authority of the Southwest Generation Utilities.
    Filed Date: 07/17/2008.
    Accession Number: 20080721-0016.
    Comment Date: 5 p.m. Eastern Time on Thursday, August 7, 2008.

    Docket Numbers: ER04-157-029; ER04-714-019; EL05-89-008.
    Applicants: Bangor Hydro-Electric Company; Florida Power & Light
Company; New England.
    Description: Central Vermont Public Service Corporation submits its
additional billings report in compliance with the Commission's 3/24/08
rehearing order in Bangor Hydro-Electric Co. etc.

    Filed Date: 07/14/2008.
    Accession Number: 20080716-0005.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER05-168-005; ER06-274-010; EL05-19-006.
    Applicants: Southwestern Public Service Company.
    Description: Golden Spread Electric Cooperative Inc. et al. submits
Amendment 1 to Offer of Settlement and Settlement Agreement.
    Filed Date: 07/18/2008.
    Accession Number: 20080722-0047.
    Comment Date: 5 p.m. Eastern Time on Friday, August 8, 2008.

    Docket Numbers: ER06-864-013; ER07-1117-004; ER05-1232-012.
    Applicants: Bear Energy LP; BE KJ LLC; J.P. Morgan Ventures Energy
Corp.
    Description: Bear Energy LP et al. submits Third Revised Sheet 1 et
al. to FERC Rate Schedule FERC 1.
    Filed Date: 07/17/2008.
    Accession Number: 20080721-0015.
    Comment Date: 5 p.m. Eastern Time on Thursday, August 7, 2008.

    Docket Numbers: ER06-1512-002.
    Applicants: Verso Androscoggin LLC.
    Description: Amendment to Request for Category 1 Seller
Determination of Verso Androscoggin LLC.
    Filed Date: 07/18/2008.
    Accession Number: 20080718-5076.
    Comment Date: 5 p.m. Eastern Time on Friday, August 8, 2008.

    Docket Numbers: ER07-1372-002.
    Applicants: Midwest Independent Transmission System.
    Description: North American Electric Reliability Corp hereby grants
Midwest ISO, Inc's request dated 4/13/07 for certification as a Joint
Registered Balancing Authority, including its Local Control Centers
etc.
    Filed Date: 07/14/2008.
    Accession Number: 20080716-0032.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER07-1421-003; ER07-1422-003; ER08-549-002; ER08-
550-002; ER08-573-001; ER08-574-001.
    Applicants: PJM Interconnection, L.L.C.; Virginia Electric and
Power Company.
    Description: Industrial Power Generating Company LLC et al. submits
a Settlement Agreement and Offer Settlement.
    Filed Date: 07/18/2008.
    Accession Number: 20080718-0197.
    Comment Date: 5 p.m. Eastern Time on Friday, August 8, 2008.

    Docket Numbers: ER08-549-002; ER08-550-002; ER08-573-001; ER08-574-
001.
    Applicants: PJM Interconnection, L.L.C.; Virginia Electric and
Power Company.
    Description: Industrial Power Generating Company LLC et al. submits
a Settlement Agreement and Offer Settlement.
    Filed Date: 07/18/2008.
    Accession Number: 20080718-0197.
    Comment Date: 5 p.m. Eastern Time on Friday, August 8, 2008

    Docket Numbers: ER08-637-003.
    Applicants: Midwest Independent Transmission System Operator, Inc.
    Description: Midwest Independent Transmission System Operator, Inc.
submits its proposed revisions to its Open Access Transmission and
Energy Markets Tariff to comply with specific directives set forth in
FERC's 6/13/08 Order.
    Filed Date: 07/14/2008.
    Accession Number: 20080715-0142.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER08-746-002.
    Applicants: Southwest Power Pool, Inc.
    Description: Southwest Power Pool, Inc. submits a amendatory filing
to correct the clerical error in the Open Access Transmission Tariff
language proposed in the June 25, 2008 filing.
    Filed Date: 07/18/2008.
    Accession Number: 20080721-0014.
    Comment Date: 5 p.m. Eastern Time on Friday, August 8, 2008.

    Docket Numbers: ER08-821-002.
    Applicants: Hazleton Generation LLC.
    Description: Hazelton Generation LLC submits an application for
determination that it is a Category 1 Seller.
    Filed Date: 07/18/2008.
    Accession Number: 20080722-0048.
    Comment Date: 5 p.m. Eastern Time on Friday, August 8, 2008.

    Docket Numbers: ER08-884-001; ER08-913-001.
    Applicants: Midwest Independent Transmission System; Independent
Transmission System Operator.
    Description: Midwest Independent Transmission System Operator, Inc.
et al. submits proposed Appendix H of the Congestion Management Process
of their Joint Operating Agreements in compliance with FERC's July 1
Order.
    Filed Date: 07/16/2008.
    Accession Number: 20080718-0196.
    Comment Date: 5 p.m. Eastern Time on Wednesday, August 6, 2008.

    Docket Numbers: ER08-996-002.
    Applicants: CBA Endeavors, LLC.
    Description: CBA Endeavors, LLC requests acceptance of FERC
Electric Tariff, Original Volume 1 under which it will engage in
wholesale sales of electric energy, and capacity at market-based rates,
the grant of certain blanket approvals and waiver etc.
    Filed Date: 07/14/2008.
    Accession Number: 20080715-0143.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER08-1147-001.
    Applicants: SG Energy LLC.
    Description: SG Energy, LLC's Amended Petition for Acceptance of
Initial Tariff, Waivers and Blanket Authority, Original Volume 1.
    Filed Date: 07/14/2008.
    Accession Number: 20080716-0004.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER08-1250-000.
    Applicants: Haverhill North Coke Company.
    Description: Haverhill North Coke Company submits an application
for Market-Based Rate Authority, Certain Blanket Authorizations and
Request for Expedited Consideration.
    Filed Date: 07/14/2008.
    Accession Number: 20080715-0200.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER08-1258-000.
    Applicants: New York Independent System Operator, Inc.
    Description: Report of tariff implementation issues and request for
tariff waivers of the New York Independent System Operator Inc.
    Filed Date: 07/14/2008.
    Accession Number: 20080715-0017.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER08-1259-000.
    Applicants: Midwest Independent Transmission System.
    Description: Midwest Independent Transmission System Operator Inc
submits First Revised Service Agreement 1497 under FERC Electric
Tariff, Third Revised Volume 1.
    Filed Date: 07/14/2008.
    Accession Number: 20080715-0018.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER08-1264-000.
    Applicants: Arizona Public Service Company.
    Description: Arizona Public Service Company submits a revision to
APS's Open Access Transmission Tariff.
    Filed Date: 07/14/2008.
    Accession Number: 20080715-0150.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER08-1265-000.
    Applicants: Southwest Power Pool, Inc.
    Description: Southwest Power Pool submits a Letter Agreement
between

SPP as Transmission Provider, American Electric Power Service
Corporation as the Transmission Customer and AEP as agent for
Southwestern Electric Power Company etc.
    Filed Date: 07/14/2008.
    Accession Number: 20080715-0149.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER08-1266-000.
    Applicants: PJM Interconnection, L.L.C.
    Description: PJM Interconnection, LLC submits an executed Interin
Interconnection Service Agreement entered into among PJM, Virginia
Electric and Power Company and Virginia Electric and Power Company.
    Filed Date: 07/14/2008.
    Accession Number: 20080715-0148.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER08-1267-000.
    Applicants: PJM Interconnection, L.L.C.
    Description: PJM Interconnection, LLC submits an interconnection
service agreement and interconnection construction agreement among PJM
PPL Renewable Energy LLC and Pennsylvania Electric Company a
FirstEnergy Company.
    Filed Date: 07/14/2008.
    Accession Number: 20080715-0147.
    Comment Date: 5 p.m. Eastern Time on Monday, August 4, 2008.

    Docket Numbers: ER08-1276-000.
    Applicants: Southern California Edison Company.
    Description: Southern California Edison Co submits a Service
Agreement for Wholesale Distribution Service et al.
    Filed Date: 07/17/2008.
    Accession Number: 20080718-0195.
    Comment Date: 5 p.m. Eastern Time on Thursday, August 7, 2008.

    Docket Numbers: ER08-1277-000.
    Applicants: ISO New England Inc., New England Power Pool.
    Description: ISO New England, Inc et al. submits 1st Revised Sheet
519 et al. to FERC Electric Tariff 3.
    Filed Date: 07/17/2008.
    Accession Number: 20080718-0248.
    Comment Date: 5 p.m. Eastern Time on Thursday, August 7, 2008.

    Docket Numbers: ER08-1278-000.
    Applicants: PacifiCorp.
    Description: PacifiCorp submits Revision 6 to Appendix A First
Revised FERC Rate Schedule 297 et al.
    Filed Date: 07/17/2008.
    Accession Number: 20080718-0247.
    Comment Date: 5 p.m. Eastern Time on Thursday, August 7, 2008.

    Docket Numbers: ER08-1279-000.
    Applicants: Southaven Power, LLC.
    Description: Southaven Power LLC submits a notice of cancellation
of FERC Electric Tariff, First Revised Volume 1.
    Filed Date: 07/18/2008.
    Accession Number: 20080722-0045.
    Comment Date: 5 p.m. Eastern Time on Friday, August 8, 2008.

    Docket Numbers: ER08-1280-000.
    Applicants: Southwest Power Pool, Inc.
    Description: Southwest Power Pool, Inc. submits the Agreements
include terms and conditions that do not conform to the standard form
of service agreement that is in SPP's Open Access Transmission Tariff.
    Filed Date: 07/18/2008.
    Accession Number: 20080722-0046.
    Comment Date: 5 p.m. Eastern Time on Friday, August 8, 2008.

    Docket Numbers: ER08-1286-000.
    Applicants: Pacific Gas and Electric Company.
    Description: Pacific Gas and Electric Company submits Revised Rate
Schedule 114 with the City and County of San Francisco.
    Filed Date: 07/22/2008.
    Accession Number: 20080723-0033.
    Comment Date: 5 p.m. Eastern Time on Tuesday, August 12, 2008.

    Docket Numbers: ER08-1287-000.
    Applicants: Nevada Power Company.
    Description: Nevada Power Company submits an executed Agreement for
Dynamic Scheduling of the Apex Generating Station between Nevada Power
Company and Las Vegas Power Company.
    Filed Date: 07/22/2008.
    Accession Number: 20080723-0032.
    Comment Date: 5 p.m. Eastern Time on Tuesday, August 12, 2008.

    Take notice that the Commission received the following electric
reliability filings:

    Docket Numbers: RR06-1-017; RR07-1-004; RR07-2-004; RR07-3-005;
RR07-4-004; RR07-5-005; RR07-6-004; RR07-7-004; RR07-8-005; RR07-8-005.
    Applicants: North American Electric Reliability Corp.
    Description: Compliance Filing of the North American Electric
Reliability Corporation in Response to March 21 2008 Order in Dockets
RR06-1 et al. including Attachments 1 through 11.
    Filed Date: 07/21/2008.
    Accession Number: 20080721-5060.
    Comment Date: 5 p.m. Eastern Time on Monday, August 11, 2008.

    Docket Numbers: RR07-14-000.
    Applicants: North American Electric Reliability Corp.
    Description: Compliance Filing of the North American Electric
Reliability Corporation in Response to FERC Order on Filing of
Reliability Enhancement Programs.
    Filed Date: 07/21/2008.
    Accession Number: 20080721-5179.
    Comment Date: 5 p.m. Eastern Time on Wednesday, August 20, 2008.

    Docket Numbers: RR07-16-004.
    Applicants: North American Electric Reliability Corp.
    Description: North American Electric Reliability Corporation's
compliance filing in Response to the Commission's June 19, 2008 Order.
    Filed Date: 07/21/2008.
    Accession Number: 20080721-5166.
    Comment Date: 5 p.m. Eastern Time on Wednesday, August 20, 2008.

    Docket Numbers: RR08-4-002.
    Applicants: North American Electric Reliability Corp.
    Description: Compliance Filing in Response to Paragraph 40 of Order
on Violation Severity Levels.
    Filed Date: 07/21/2008.
    Accession Number: 20080721-5177.
    Comment Date: 5 p.m. Eastern Time on Wednesday, August 20, 2008.
    Any person desiring to intervene or to protest in any of the above
proceedings must file in accordance with Rules 211 and 214 of the
Commission's Rules of Practice and Procedure (18 CFR 385.211 and
385.214) on or before 5 p.m. Eastern time on the specified comment
date. It is not necessary to separately intervene again in a subdocket
related to a compliance filing if you have previously intervened in the
same docket. Protests will be considered by the Commission in
determining the appropriate action to be taken, but will not serve to
make protestants parties to the proceeding. Anyone filing a motion to
intervene or protest must serve a copy of that document on the
Applicant. In reference to filings initiating a new proceeding,
interventions or protests submitted on or before the comment deadline
need not be served on persons other than the Applicant.
    The Commission encourages electronic submission of protests and
interventions in lieu of paper, using the FERC Online links at http://
www.ferc.gov. To facilitate electronic service, persons with Internet
access who will eFile a document and/or be listed as a contact for an
intervenor must create and validate an eRegistration account using the
eRegistration link. Select the eFiling link to log on and submit the
intervention or protests.
    Persons unable to file electronically should submit an original and
14 copies of the intervention or protest to the Federal Energy
Regulatory Commission,

888 First St., NE., Washington, DC 20426.
    The filings in the above proceedings are accessible in the
Commission's eLibrary system by clicking on the appropriate link in the
above list. They are also available for review in the Commission's
Public Reference Room in Washington, DC. There is an eSubscription link
on the Web site that enables subscribers to receive e-mail notification
when a document is added to a subscribed dockets(s). For assistance
with any FERC Online service, please e-mail<EMAIL_ADDRESS>
or call<PHONE_NUMBER> (toll free). For TTY, call<PHONE_NUMBER>.

Nathaniel J. Davis, Sr.,
Deputy Secretary.
[FR Doc. E8-17498 Filed 7-30-08; 8:45 am]

BILLING CODE 6717-01-P


The EDMVS The EDMVS''

Draft Work Plan Draft Work Plan Presentation to the EDMVS,

Presentation to the EDMVS,

December 10, 2003 December 10, 2003 Purpose of Today's Purpose of Today's WorkPlan WorkPlan Show progress of EDSP Show progress of EDSP Provide the status of each assay Provide the status of each assay Project what's next Project what's next Tier I Screening Battery Tier I Screening Battery recommended for consideration by EDSTAC recommended for consideration by EDSTAC Steroidogenesis Steroidogenesis Pubertal Pubertal  female female Fish Screen Fish Screen aka aka short term fish reproduction short term fish reproduction Amphibian Metamorphosis Amphibian Metamorphosis Estrogen / Androgen receptor binding Estrogen / Androgen receptor binding Hershberger Hershberger Uterotrophic Uterotrophic Alternative Assays Alternative Assays recommended for consideration by EDSTAC recommended for consideration by EDSTAC Tier I Tier I Aromatase Aromatase Pubertal male Pubertal male Adult 14 Adult 14   day intact male day intact male Tier ?

Tier ?

In In Utero Utero through Lactation through Lactation Tier II Assays Tier II Assays recommended for consideration by EDSTAC recommended for consideration by EDSTAC Mammalian 2 Mammalian 2 generation generation Avian 2 Avian 2 gen. Reproduction gen. Reproduction Amphibian Development and Repro.

Amphibian Development and Repro.

Invertebrate (

Invertebrate ( Mysid Mysid) Lifecycle ) Lifecycle Fish Lifecycle Fish Lifecycle Tier I Assays Tier I Assays Steroidogenesis Steroidogenesis Milestone Milestone Current Status Current Status DRP/ Protocol DRP/ Protocol   June June 02 02  cell based ( H295R) Dev by ORD cell based ( H295R) Dev by ORD Prevalidation Prevalidation  sectional testes sectional testes optimization optimization   June & Aug 03 June & Aug 03  multichem multichem & interlab interlab In Lab In Lab  cell based ( H295R)

cell based ( H295R) In Lab In Lab Validation Validation  inter inter lab lab to lab June 04 to lab June 04 Current Status = dates presented to EDMVS &

Current Status = dates presented to EDMVS &

other information other information Pubertals Pubertals   m& f m& f Milestone Milestone DRP equivalent DRP equivalent Prevalidation Prevalidation  Single Dose Study Single Dose Study  Multi Multi chemical & multi chemical & multi dose dose Protocols Protocols  Multi Multi chemical & multi chemical & multi dose dose  Restricted Feeding Study Restricted Feeding Study Validation ( inter Validation ( inter lab)

lab) Current Status Current Status   Dec 01 Dec 01   Dec Dec 01 01   Dec Dec 01 01 Today Today   July 02 July 02 To lab Feb 04 To lab Feb 04 Fish Screen Fish Screen Milestones Milestones Current Status Current Status DRP/ Protocol DRP/ Protocol   Mar 02 Mar 02 Prevalidation Prevalidation  FHM FHM   Mar 02 Mar 02  FHM w/ multi FHM w/ multi chemicals chemicals Report writing Report writing  Comparative Study Plans:

Comparative Study Plans:   Mar Mar 02 02  Results: Comparative Studies Results: Comparative Studies Vitellogenin Vitellogenin Methods, FHM assays Methods, FHM assays   Aug 03 Aug 03 Validation ( inter Validation ( inter lab) depends on OECD lab) depends on OECD Phase 1A ( OECD)

Phase 1A ( OECD)   Aug 03 Aug 03 Phase 1B ( OECD)

Phase 1B ( OECD) Spring 04 Spring 04 Amphibian Metamorphosis Amphibian Metamorphosis Milestone Milestone Current Status Current Status DRP/ Protocol DRP/ Protocol   July 02 July 02 Pre Pre validation validation prometamorphosis prometamorphosis  optimize protocol ( US)

optimize protocol ( US) Spring 04 Spring 04  protocol demonstration to lab protocol demonstration to lab Validation ( inter Validation ( inter lab OECD) TBD lab OECD) TBD  Phase I ( protocol optimization)

Phase I ( protocol optimization) Spring 04 Spring 04 " Phase 2 Phase 2" Plan Plan Spring 04 Spring 04 ER / AR binding ER / AR binding ICCVAM ICCVAM Scientific Expert Panel Scientific Expert Panel'' s May 2002 s May 2002 retrospective validation retrospective validation EDMVS briefed by ICCVAM July 2002 EDMVS briefed by ICCVAM July 2002 Expert Panel Final Report Sept 2002 Expert Panel Final Report Sept 2002 ICCVAM Final Report May 2003 ICCVAM Final Report May 2003 EDSP: AR in lab (

EDSP: AR in lab ( preval preval) Update Today Update Today EDSP: ER in lab ( valid) Oct 02 EDSP: ER in lab ( valid) Oct 02 Oct 04 Oct 04 Aromatase Aromatase Milestones Milestones Current Status Current Status DRP / Protocol DRP / Protocol   Mar 02 Mar 02 Prevalidation Prevalidation  placental placental microsomal microsomal assay assay   June 03 June 03 compare bovine, human,

compare bovine, human,

porcine uterine tissue porcine uterine tissue  comparison: human placental &

comparison: human placental &

recombinant, multi recombinant, multi chem chem Today Today Validation ( inter Validation ( inter lab)

lab) to lab Jan 04 to lab Jan 04 In In Utero Utero  Lactation Lactation Milestone Milestone Current Status Current Status DRP DRP   Dec Dec 02 02  Protocol review Protocol review   Mar 02 Mar 02 Prevalidation Prevalidation  Protocol Demo Protocol Demo Data Analysis Data Analysis  Multi Multi chem chem study TBD study TBD Validation ( inter Validation ( inter lab)

lab) TBD TBD Tier II Assays Tier II Assays Mammalian 2 Mammalian 2 generation generation Milestone Milestone Current Status Current Status Prevalidation Prevalidation One One gen. Ext. Protocol gen. Ext. Protocol   Dec Dec 02 02 Propylthiouracil Propylthiouracil Study Study   July 02 July 02 One One gen gen Ext. study Ext. study   June 03 June 03 Validation ( inter Validation ( inter lab) TBD lab) TBD Avian 2 Avian 2 gen. Reproduction gen. Reproduction Milestone Milestone Current Status Current Status DRP/ Protocol DRP/ Protocol   Aug 03 Aug 03 Prevalidation Prevalidation  Avian Dosing Study Plan Avian Dosing Study Plan   Mar 02 Mar 02  Avian species Comparison Avian species Comparison Report writing Report writing  Avian Dose Study Avian Dose Study In Lab In Lab  Protocol demo future Protocol demo future Validation ( inter Validation ( inter lab OECD) future lab OECD) future Amphibian Amphibian Dev. & Repro.

Dev. & Repro.

Milestones Milestones Current Status Current Status DRP/ Protocol DRP/ Protocol Spring 04 Spring 04 Prevalidation Prevalidation  transferable protocol future transferable protocol future  multi multi chem chem study future study future Validation ( inter Validation ( inter lab) future lab) future Mysid Lifecycle Mysid Lifecycle Milestones Milestones Current Status Current Status DRP/ Protocol DRP/ Protocol   July 02 July 02 Prevalidation Prevalidation  transferable protocol transferable protocol Spring 04 Spring 04  multi multi chem chem study future study future Validation ( inter Validation ( inter lab OECD) future lab OECD) future Fish Lifecycle Fish Lifecycle Milestones Milestones Current Status Current Status DRP/ Protocol DRP/ Protocol   Dec Dec 02 02 Prevalidation Prevalidation  protocol demo protocol demo In Lab In Lab  multi multi chem chem study future study future Validation ( inter Validation ( inter lab OECD) future lab OECD) future Spring/ Summer 2004 Spring/ Summer 2004 Amphibian DRP ( Tier II)

Amphibian DRP ( Tier II)

Amphibian Screen protocol ( Tier I)

Amphibian Screen protocol ( Tier I)

Fish Screen multi Fish Screen multi chemical results chemical results Fish Screen Phase 1B ( OECD)

Fish Screen Phase 1B ( OECD)

Mysid Mysid Transferable Protocol Transferable Protocol In In Utero Utero Through Lactation Through Lactation Avian Species Comparison Results Avian Species Comparison Results EPA Docket EPA Docket www. epa. gov/ edocket www. epa. gov/ edocket June 03 OPPT June 03 OPPT 2003 2003 0016 0016 August 03 OPPT August 03 OPPT 2003 2003 0027 0027 Dec 03 OPPT Dec 03 OPPT 2003 2003 0064 0064 EDSP website EDSP website www. epa. gov/ scipoly/ oscpendo www. epa. gov/ scipoly/ oscpendo