[Federal Register: July 12, 2006 (Volume 71, Number 133)]
[Notices]
[Page 39379-39382]
[DOCID:fr12jy06-115]

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SECURITIES AND EXCHANGE COMMISSION

[Release No. 34-54103; File No. SR-NASD-2004-043]

Self-Regulatory Organizations; National Association of Securities
Dealers, Inc.; Order Approving a Proposed Rule Change and Notice of
Filing and Order Granting Accelerated Approval of Amendment No. 4 to
the Proposed Rule Change Relating to Disclosure of Fees and Expenses in
Mutual Fund Performance Sales Material

July 5, 2006.
    Pursuant to Section 19(b)(1) of the Securities Exchange Act of 1934
(``Act'') \1\ and Rule 19b-4 thereunder,\2\ notice is hereby given that
on December 12, 2005, the National Association of Securities Dealers,
Inc. (``NASD''), filed with the Securities and Exchange Commission
(``SEC'' or ``Commission'') Amendment No. 4 to the proposed rule change
as described in Items I, II, and III below, which Items have been
prepared by NASD. This order notices, and solicits comments from
interested persons on, Amendment No. 4 to the proposal and approves the
proposal as amended.
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    \1\ 15 U.S.C. 78s(b)(1).
    \2\ 17 CFR 240.19b-4.
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I. Self-Regulatory Organization's Statement of the Terms of Substance
of the Proposed Rule Change

    NASD is proposing to amend NASD Rules 2210 and 2211 to require
member communications with the public, other than institutional sales
material and public appearances, that present mutual fund performance
information (``performance sales material'') to disclose the fund's
fees, expenses and standardized performance. The text of the proposed
rule change is available on NASD's Web site (http://www.nasd.com), at

NASD's principal office, and at the Commission's Public Reference Room.

II. Self-Regulatory Organization's Statement of the Purpose of, and
Statutory Basis for, the Proposed Rule Change

    In its filing with the Commission, NASD included statements
concerning the purpose of and basis for the proposed rule change and
discussed any comments it received on the proposed rule change. The
text of these statements may be examined at the places specified in
Item IV below.

Purpose

    On March 10, 2004, NASD filed with the Commission a proposal to
amend NASD Rules 2210 and 2211 to require that mutual fund
communications with the public that provide performance data disclosure
the fund's fees, expenses and standardized performance. NASD believes
these new requirements would improve investor awareness of the costs of
buying and owning a mutual fund, facilitate comparison of funds and
make the presentation of standardized performance more prominent. The
Commission published the proposed rule change and Amendment No. 1
thereto for comment in the Federal Register on August 27, 2004.\3\ The
Initial Proposal would have required that:
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    \3\ Exchange Act Release No. 50226 (Aug. 20, 2004), 69 FR 52738
(Aug. 27, 2004) (``Initial Proposal''). Amendment No. 2, which
changed the proposal in response to industry comments, was filed on
May 2, 2005. Amendment Nos. 3 and 4, which altered the proposed rule
change to harmonize it with the requirements of Rule 482 and Rule
34b-1, were filed on July 27, 2005, and December 13, 2005,
respectively. Amendment No. 4 replaced Amendment Nos. 2 and 3 in
their entirety.

 Performance sales material disclose:
     The standardized performance information mandated by Rule
482 under the Securities Act of 1933 \4\ (``Rule 482'') and Rule 34b-1
under the Investment Company Act of 1940 \5\ (``Rule 34b-1'');
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    \4\ 17 CFR 230.482.
    \5\ 17 CFR 270.34b-1.
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     To the extent applicable, the maximum front-end and
deferred sales charges stated in the fund's current prospectus; and
     The fund's total annual operating expense ratio, as stated
in the investment company's current prospectus.
 All required performance information and fee disclosure be set
forth:
     Clearly and prominently, and standardized performance
information be in a type size at least as large as that used for any
non-standardized performance information;
     With respect to any radio, television or video
advertisements, with equal prominence to that given to any non-
standardized performance information; and
     In any advertisement, other than radio, television or
video advertisements, in a prominent text box that contains only the
required information.

Comments Received on the Initial Proposal and NASD's Response

    The Commission received five comment letters on the Initial
Proposal.\6\ Commenters' concerns fell into three principal categories.
First, commenters either opposed the text box requirement in its
entirety or believed that, to be workable, NASD needed to modify the
proposal to allow greater flexibility for electronic media such as Web
sites. Second, some commenters stated that ongoing fees should be
calculated net of fee waivers and expense reimbursements. Finally,
commenters urged NASD to provide members with ample time to comply with
any new rule and to allow the use of templates when filing revised
sales material. A summary of the comment letters and NASD's response is
set forth below.
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    \6\ Letters to Jonathan G. Katz, Secretary, Commission, from
Colon Brown, President, Brown & Brown Securities, Inc. (Sept. 10,
2004) (``Brown Letter''); Alexander G. Gavis, Vice President and
Associate General Counsel, Fidelity Investments (Oct. 12, 2004)
(``Fidelity Letter''); Frances M. Stadler, Deputy Senior Counsel,
Investment Company Institute (Sept. 17, 2004) (``ICI Letter'');
Stuart R. Strachan, Chairman, Investment Company Committee of the
Securities Industry Association (Sept. 17, 2004) (``SIA Letter'');
Heidi Stam, Principal, Securities Regulation, Vanguard Group, Inc.
(Sept. 17, 2004) (``Vanguard Letter''). In addition, NASD received a
letter from Forrest R. Foss, Associate Counsel, T. Rowe Price
Associates, Inc. (Dec. 6, 2004) (``T. Rowe Price Letter''). We have
included NASD's responses to the concerns expressed in the T. Rowe
Price Letter in the discussion below.
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Text Box Requirement
    Three commenters objected that the proposed text box requirement
would be unduly restrictive and would make it difficult to advertise
the performance of multiple funds.\7\ These commenters also

stated that the prohibition against including non-required information
in the text box could result in poorly designed and repetitive fund
advertisements. Two of the commenters recommended as an alternative to
the text box a requirement that a fund's expense ratio be disclosed in
the same manner in which a fund's maximum sales charge is required to
be disclosed under Rule 482, which includes prominence requirements for
certain required disclosures (e.g., for sales charges).\8\
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    \7\ Fidelity Letter, ICI Letter, T. Rowe Price Letter. Two of
the commenters opined that an advertisement that compares a fund's
performance against a benchmark index could not include the index
performance in the text box, and thus might have to show the fund's
performance again outside the text box in order to make an effective
comparison.
    \8\ Fidelity Letter, ICI Letter.
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    Finally, three commenters objected to applying the text box
requirement to Web sites, arguing that the requirement does not take
into consideration how individuals typically read and navigate Web
sites and retrieve information (such as through the use of
hyperlinks).\9\ These commenters also urged NASD to modify the proposal
to allow the use of hyperlinks to link from non-standardized
performance information to the required standardized information.
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    \9\ Fidelity Letter, ICI Letter, Vanguard Letter.
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    NASD's response to comments: In response to commenters' concerns,
NASD amended the prominence requirements of proposed NASD Rule
2210(d)(3)(B) to: (1) Eliminate language that might be deemed
inconsistent with the prominence requirements of Rule 482 and Rule 34b-
1; (2) apply the text box rule only to print advertisements; and (3)
permit the inclusion of other pertinent comparative data and
disclosures required by Rule 482 and Rule 34b-1 in the text box.\10\
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    \10\ Amendment No. 4.
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    As a result of this amendment, Web sites and other electronic
advertisements would not have to present the required performance and
fee information within a text box. And in those print advertisements
where the text box still would be required, members would be allowed to
present comparative performance and fee data (e.g., non-standardized
fund performance, the performance of a relevant benchmark index, or a
comparison of the fund's expense ratio to the average expense ratio for
similar funds) and disclosures required by rule 482 and Rule 34b-1.
    The information required by proposed NASD Rule 2210(d)(3)(A) (i.e.,
the standardized performance information, maximum sales charge, and
total annual fund operating expenses) would have to be set forth
prominently. NASD members could meet this prominence requirement by
presenting this information in accordance with the prominence and
proximity requirements of Rule 482 and Rule 34b-1.\11\ Additionally,
members would be required to present a fund's total annual operating
expenses in a manner that meets the prominence and proximity
requirements under Rule 482 for disclosure of a fund's maximum sales
charge. Thus, for example, the quotations of the standardized average
annual total returns for one, five and ten-year periods would have to
be set forth with equal prominence, and any quotations of non-
standardized performance could not be set forth in greater prominence
than the standardized performance.\12\ Similarly, the disclosures of a
fund's maximum sales load and total annual operating expenses generally
would have to be presented in print advertisements ``in a type size at
least as large as and of a style different from, but at least as
prominent as, that used in the major portion of the advertisement * *
*.'' \13\
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    \11\ See Securities Act Rules 482(b) and 482(d).
    \12\ See Securities Act Rules 482(d)(3)(iii) and 482(d)(5)(iv).
    \13\ See Securities Act Rule 482(b)(5). Rule 482(b)(5) also
provides that when performance data is presented in a print
advertisement in a type size smaller than that of the major portion
of the advertisement, the maximum sales load may appear in a type
size no smaller than that of the performance data.
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    NASD also has reconsidered the use of hyperlinks to show
standardized performance information. Given that NASD no longer would
require Web sites to present required disclosures in a text box, NASD
stated that it also would be appropriate for members to present
standardized performance and other required disclosures through the use
of a hyperlink, provided that the required disclosures are prominent
and consistent with the standards of Rule 482.\14\
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    \14\ Amendment No. 4.
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Calculation of Expense Ratio
    The Initial Proposal would have required performance sales material
to show a fund's annual operating expenses as derived from the fund's
most recent prospectus.\15\ Two commenters stated that the proposal
should be modified to allow member firms to disclose a fund's current
expense ratio net of fee waivers and reimbursements, as long as the
fact of the subsidization is disclosed.\16\
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    \15\ Proposed NASD Rule 2210(d)(3)(A)(ii)(b).
    \16\ Fidelity Letter, ICI Letter.
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    One commenter stated that expense ratios should be calculated in
accordance with Item 3 of Form N-1A, without taking into account fee
waivers and reimbursements because, in the commenter's opinion,
prospective investors should base their decisions on the long-term
costs of a fund rather than its current costs (which may include
subsidization).\17\
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    \17\ Vanguard Letter.
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    NASD's response to comments: In response to commenters' concerns,
NASD stated that since fund advertisements, like prospectuses, are
directed to prospective investors, any required expense ratio
disclosure should not reflect fee waivers or reimbursements.\18\
According to NASD, the proposal would not preclude performance sales
material from also presenting a fund's expense ratio net of fee waivers
and reimbursements, as long as the sales material also presents the
unsubsidized expense ratio, and the member presents the subsidized
expense ratio in a fair and balanced manner in accordance with the
standards of Rule 2210. NASD stated that it would expect that, if a
subsidized expense ratio were presented, the sales material would
disclose whether the fee waivers or expense ratios were voluntary or
mandated by contract, and the time period during which the fee waiver
or expense reimbursement obligation, if any, remains in effect.\19\
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    \18\ Amendment No. 4.
    \19\ In addition, one commenter opined that the Original
Proposal was limited to disclosure of quantitative statistics rather
than more qualitative information. Brown Letter. The commenter
believed that the more important information involves the
credentials and experience of mutual funds' advisors, the investment
disciplines they follow and the ethical standards they employ
regarding the distribution of their shares. The commenter
recommended that such information be made available to investors in
reasonably large print and understandable language. In response,
NASD stated that the commenter's recommendation is beyond the scope
of the proposal.
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Compliance Lead Time and the Use of Templates
    The Initial Proposal indicated that NASD would publish a Notice to
Members announcing Commission approval of the proposed rule change
within 60 days after such approval, and that the new requirements would
become effective 30 days after publication of the Notice to Members.
Three commenters requested that NASD provide additional time for
members to comply with the proposal's new requirements.\20\
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    \20\ Fidelity Letter, ICI Letter, Vanguard Letter. Two of the
commenters also recommended that compliance with the proposal not be
required until after the end of the second full calendar quarter
following Commission approval of the proposed rule change. Fidelity
Letter, ICI Letter. One of the commenters recommended that firms be
given at least six months, and preferably nine to twelve months, to
comply with the rule change. Vanguard Letter.

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    Two commenters requested that NASD allow member firms to file
templates to show how substantially similar performance sales material
would be revised to comply with the new standards.\21\ These commenters
believe that allowing templates to be filed would reduce compliance and
filing costs for member firms while allowing NASD staff to identify and
address any concerns with the format and content of performance sales
material.
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    \21\ Fidelity Letter, ICI Letter.
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    NASD's response to comments: In response to commenters' concerns,
NASD amended the proposed effective date as follows: Should the
Commission approve the proposal, NASD will publish a Notice to Members
announcing Commission approval within 60 days thereafter. The proposal
would become effective six months following the calendar quarter ended
after publication of the Notice.
    In Amendment No. 4, NASD also agreed to permit the filing of
templates on a case-by-case basis to show compliance with the new rule
requirements.\22\
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    \22\ To the extent that NASD permits members to file templates
of sales material to show compliance with the new requirements of
proposed NASD Rule 2210(d)(3) or for any other purpose, all such
sales material covered by the template would be deemed filed with
NASD. Pursuant to Rule 24b-3 under the Investment Company Act of
1940 (``Investment Company Act''), sales material filed with NASD is
deemed filed with the Commission for purposes of Section 24(b) of
the Investment Company Act.
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III. Solicitation of Comments

    Interested persons are invited to submit written data, views and
arguments concerning Amendment No. 4, including whether the amendment
is consistent with the Act. Comments may be submitted by any of the
following methods:

Electronic Comments

     Use the Commission's Internet comment form (http://www.sec.gov/rules/sro.shtml.
); or     Send an e-mail to<EMAIL_ADDRESS>Please include

File Number SR-NASD-2004-043 on the subject line.

Paper Comments

     Send paper comments in triplicate to Jonathan G. Katz,
Secretary, Securities and Exchange Commission, 100 F Street, NE.,
Washington, DC 20549-1090.

All submissions should refer to File Number SR-NASD-2004-043. This file
number should be included on the subject line if e-mail is used. To
help the Commission process and review your comments more efficiently,
please use only one method. The Commission will post all comments on
the Commission's Internet Web site (http://www.sec.gov/rules/sro.shtml
). Copies of the submission, all subsequent amendments, all

written statements with respect to the proposed rule change that are
filed with the Commission, and all written communications relating to
the proposed rule change between the Commission and any person, other
than those that may be withheld from the public in accordance with the
provisions of 5 U.S.C. 552, will be available for inspection and
copying in the Commission's Public Reference Room, 100 F Street, NE.,
Washington, DC 20549. Copies of such filing also will be available for
inspection and copying at the principal office of NASD.
    All comments received will be posted without change; the Commission
does not edit personal identifying information from submissions. You
should submit only information that you wish to make available
publicly. All submissions should refer to the File Number SR-NASD-2004-
043 and should be submitted on or before August 2, 2006.

IV. Discussion

    After careful consideration, the Commission finds that the proposed
rule change is consistent with the Act and the rules and regulations
thereunder applicable to NASD.\23\ Specifically, the Commission
believes that the proposal is consistent with Section 15A(b)(6) of the
Act \24\ in that it is designed to prevent fraudulent and manipulative
acts and practices, to promote just and equitable principles of trade,
and, in general, to protect investors and the public interest. The
Commission believes that the proposed rule change is designed to
accomplish these ends by requiring additional disclosures in mutual
fund performance sales materials that should enable investors to
compare the performance of various mutual funds and to make informed
comparisons regarding the actual cost of buying and owning various
mutual funds.
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    \23\ In approving the proposal, the Commission has considered
the proposed rule's impact on efficiency, competition, and capital
formation. See 15 U.S.C. 78c(f).
    \24\ 15 U.S.C. 78o-3(b)(6).
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    NASD has requested that the Commission approve Amendment No. 4 to
the proposed rules change on an accelerated basis.\25\ The Commission
finds good cause for approving Amendment No. 4 to the proposed rule
change prior to the 30th day after the date of publication of notice of
filing thereof in the Federal Register.\26\ NASD amended the rule
proposal in response to commenters and to harmonize the rule proposal
with current regulatory disclosure requirements. Amendment No. 4 allows
more flexibility in the way in which required disclosures are presented
while retaining the content and prominence requirements for those
disclosures, thereby easing compliance burdens without sacrificing the
investor-protection goals of the proposal.
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    \25\ Telephone conference between Joseph Savage, Associate Vice
President, Investment Companies Regulation, NASD, and David W.
Blass, Branch Chief, Division of Market Regulation, Commission, on
July 5, 2006.
    \26\ The Commission further notes that both the rule filing SR-
NASD-2004-043 and the amendments thereto have been available since
their respective filing dates on NASD's Web site http://www.nasd.com
.

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    Specifically, in response to commenters, NASD amended the proposal
to require text boxes for print advertisements only. Web sites and
other electronic advertisements would not have to present the required
performance and fee information within a text box. NASD also expanded
the categories of information that would be allowed within the text
box. Members would be allowed to include within the text box
comparative performance and fee data (e.g., non-standardized fund
performance, the performance of a relevant benchmark index, or a
comparison of the fund's expense ratio to the average expense ratio for
similar funds) and the disclosures required by Rule 482 and Rule 34b-
1.\27\
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    \27\ NASD Rule 2210(d)(3)(B).
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    Amendment No. 4 also harmonizes the proposed disclosure standards
with those that are already required under Rule 482 and Rule 34b-1 to
ensure that member firms are able to comply simultaneously with both
NASD and SEC rules. NASD also provided firms with guidance regarding
the amount of time members will have to comply with the new
requirements. NASD also agreed that the filing of templates may be
appropriate to show how similar performance sales material will be
revised to comply with the new standards. Use of templates should help
firms obtain useful guidance from NASD staff to ensure that the
required disclosures comport with the new provisions.
    The Commission believes that NASD's proposed changes in Amendment
No. 4 strengthen and

clarify the proposed rule change in direct response to issues raised by
commenters and raise no new regulatory issues. Accordingly, the
Commission believes that the accelerated approval of Amendment No. 4 is
appropriate.

V. Conclusion

    It is therefore ordered, pursuant to Section 19(b)(2) of the
Act,\28\ that the proposed rule change, as amended, (SR-NASD-2004-043)
is approved, and that Amendment No. 4 to the proposed rule change be,
and hereby is, approved on an associated basis.
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    \28\ 15 U.S.C. 78s(b)(2).

    For the Commission, by the Division of Market Regulation,
pursuant to delegated authority.\29\
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    \29\ 17 CFR 200.30-3(a)(12).
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J. Lynn Taylor,
Assistant Secretary.
[FR Doc. 06-6137 Filed 7-11-06; 8:45 am]

BILLING CODE 8010-01-M


UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

Office of Chemical Safety and Pollution Prevention

MEMORANDUM

July 1, 2015

SUBJECT:	Cyprodinil – Acute and Chronic Dietary and Drinking Water Exposure and Risk Assessment For The Expansions of Existing Crop Group/Representative Commodity Uses to Stone Fruit Group 12-12, and Adding New Uses on the Artichoke, Guava, Pomegranate, Passionfruit, Feijoa, Jaboticaba, Wax Jambu, Starfruit, and Acerola and Amended Uses on Greenhouse Cucumbers and Small Tomatoes.

PC Code:  288202	DP Barcode: D425997

Decision No.:  490951	Registration No.: 100-811, 100-1317, 100-828, & 100-953

Petition No.:  4e8273	Regulatory Action:  Section 3

Risk Assessment Type:  Dietary	Case No.:  NA

TXR No.:  NA	CAS No: 121552-61-2

MRID No.:  NA	40 CFR:  180.532

FROM:	Thurston G. Morton, Chemist

Risk Assessment Branch IV

Health Effects Division (7509P)

THROUGH:	Pete Savoia, Chemist

		Meheret Negussie, Chemist

		Dietary Exposure Science Advisory Council (DESAC),

		and

		Charles Smith, Acting Branch Chief

Health Effects Division (7509P)

TO:		Laura Nollen/Barbara Madden

Risk Integration, Minor Use & Emergency Response Branch                    Registration Division (RD) (7505P)

This document provides an acute and chronic dietary and drinking water risk analyses of exposures resulting from use of cyprodinil as a fungicide on food crops.  This assessment supports requests for the expansion of existing crop group fruit, stone, group 12-12, and adding new uses on the globe artichoke, guava, pomegranate, passionfruit, feijoa, jaboticaba, wax jambu, starfruit, and acerola and amended uses on greenhouse cucumbers and small tomatoes.

Executive Summary

Acute and chronic dietary risk assessments were conducted for cyprodinil using the Dietary Exposure Evaluation Model (DEEM-FCID, Version 3.18), which incorporates consumption data from USDA’s National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA).  This dietary survey was conducted from 2003 to 2008.

Acute Dietary Exposure Analysis Results and Characterization

A conservative acute dietary exposure analysis was performed for the general U.S. population and various population subgroups.  Tolerance level residues and 100 % crop treated assumptions were used.  DEEM default and empirical processing factors were used to modify the tolerance values.  The acute analysis incorporated the 1 in 10 year peak surface drinking water estimate from application of cyprodinil to grapes.    SEQ CHAPTER \h \r 1 The resulting 95th percentile acute exposure estimates are not of concern for the general U.S. population or any of the other population subgroups.  The subgroup with the highest risk estimate is children 1-2 years old with a % acute population adjusted dose (aPAD) of 8.6%.  The % aPAD for the general U.S. population is 4.8%.

Chronic Dietary Exposure Analysis Results and Characterization

A partially refined chronic dietary exposure analysis was performed for the general U.S. population and various population subgroups.  For the chronic dietary analysis, tolerance level residues for most commodities; average field trial residues for pome fruit, head lettuce, leaf lettuce, spinach, tomato, and grapes; and 100% crop treated assumptions were used.  DEEM default and empirical processing factors were used to modify the tolerance values.  The chronic analysis incorporated the 10 year average surface drinking water estimate from application of cyprodinil to grapes.  Chronic dietary risk estimates are not of concern for the general U.S. population or any of the other population subgroups.  The subgroup with the highest risk estimate is children 1-2 years old with a % chronic PAD (cPAD) of 85%.  The % cPAD for the general U.S. population is 29%.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the PAD.  The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, etc) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link:    HYPERLINK "http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf"  http://www.epa.gov/fedrgstr/EPA_PEST/2000/July/Day_12/6061.pdf  ; or see SOP 99.6 (8/20/99).

The most recent dietary risk assessment for cyprodinil was conducted by T. Morton (3-May-2012; DP#390233).

II.	Residue Information

Residues of Concern

The metabolism of cyprodinil has been studied in apple, peach, potato, tomato, and wheat.  The residue of concern in plants is the parent compound cyprodinil as determined by the HED Metabolism Assessment Review Committee (MARC) (D243198, G. Kramer, 3/11/98).  The nature of the residue in ruminants is adequately understood based on acceptable lactating goat metabolism studies.  HED has concluded that the residues of concern for both risk assessment and the tolerance definition should include the combined residues of cyprodinil and free and conjugated CGA-304075, expressed in parent equivalents (D345970 and D345182, G. Kramer, 6/4/08).  The water residues of concern as determined by MARC are the parent and CGA 249287 (4-cyclopropyl-6-methylpyrimidin-2-amine) (D292557, 6/8/03).  HED continues to consider these metabolites and degradates to be the residues of concern.

Table 1:  Summary of Residues of Concern for Cyprodinil

Matrix	Residues of Concern

	For Risk Assessment	For Tolerance Expression

Plants	cyprodinil	cyprodinil

Livestock	cyprodinil and CGA-304075	cyprodinil and CGA-304075

Water	cyprodinil and CGA 249287	NA

Established/Recommended Tolerances

Permanent tolerances are established (40 CFR §180.532(a)) for residues of cyprodinil per se in/on a variety of crop commodities, at levels ranging from 0.02 ppm in/on almonds to 340 ppm in citrus oil.  Recommended tolerances for the proposed amended/new uses are as follows (D421157, T. Morton, 04/23/2015).

Artichoke…..	4.0 ppm

Guava	1.5 ppm

Passionfruit………………..………………….……………… …………….1.5 ppm

Feijoa………………..………………….…………………… ….………….1.5 ppm Jaboticaba………………..……………………………….… …………..….1.5 ppm

Wax Jambu………………..……………………………….……… ……….1.5 ppm

Starfruit 	1.5 ppm

Acerola	1.5 ppm

Pomegranate	7.0 ppm

Fruit, stone, group 12-12……………...	2.0 ppm

HED continues to recommend that the current tolerance expression for animal commodities be changed to reflect both parent and metabolite CGA-304075 (4-[(4-cyclopropyl-6-methyl-2-2-pyrimidinyl)amino]-phenol).

Residues Used in the Acute and Chronic Analysis

For the acute dietary analysis, tolerance level residues and 100% crop treated assumptions were used for all treated commodities.  For the chronic dietary analysis, tolerance level residues for most commodities; average field trial residues for pome fruit, head lettuce, leaf lettuce, spinach, tomato, and grapes; and 100% crop treated assumptions were used.  Default processing factors were used for most processed commodities, except for tomato paste/puree in the chronic(1x) and lemon/lime juice (1x).  Residues used in the acute and chronic dietary analysis are provided in Table 2.  Average residues where noted were used in the chronic dietary analysis.

Table 2. Residue Estimates Used in the Cyprodinil Acute and Chronic Dietary/Drinking Water Analysis

Commodity	Tolerance (ppm)

Crop Subgroup 1B, except sugarbeet	0.75

Crop Group 2 	10

Onion, bulb subgroup 3-07A	0.6

Onion, green subgroup 3-07B	4.0

Crop Subgroup 4A 	50 tolerance/0.87 avg head lettuce

50 tolerance/13 avg leaf lettuce

50 tolerance/11.8 avg spinach

Crop Subgroup 4B	30

Crop Subgroup 5A Head and stem 	1.0

Crop Subgroup 5B Leafy Brassica greens 	10

Bean, dry; Bean, succulent	0.6

Vegetable, fruiting, group 8-10	1.5

Crop Group 9	0.7

Lemon, Lime	0.6

Citrus Oil	60

Pome fruit, Crop group 11-10 (B. Cropp-Kohlligian, D378920, 10/27/10) 1.7 tolerance/0.50 avg apple

1.7 tolerance/0.38 avg pear

Stone fruit, Crop group 12	2

Caneberry, subgroup 13-07A	10

Bushberry subgroup 13-07B	3

Small fruit vine climbing subgroup 13-07F, except fuzzy kiwifruit (G. Kramer, D247620, 6/14/02)	3.0 tolerance/0.81 avg grapes

Low growing berry subgroup 13-07G, except cranberry	5.0 (inc. strawberry)

Almond	0.02

Pistachio	0.1

Crop Subgroup 19A Herb Fresh (except parsley)               	3

Crop Subgroup 19A Herb Dried (except parsley)               	15

Parsley, dried leaves            	170

Parsley leaves	35

Rape seed oil (canola, seed)	0.03

Avocado,  Canistel; Mango; Papaya; Sapodilla; Sapote, black; Sapote, mamey; Star apple	1.2

Dragonfruit	2.0

Kiwifruit	1.8

Watercress	20

Beef, Goat, Horse, Sheep, meat byproducts (including liver and kidney ) 0.02

Grape, raisin	5.0

Turnip, greens	10.0

III.	Percent Crop Treated Information

The acute and chronic dietary exposure analyses assumed 100% crop treated (CT).

IV.	Drinking Water Data

WC in surface water is 34.8 μg/L for the total residues of cyprodinil plus CGA-249287.  The chronic EDWC in surface waters is 24.7 μg/L for the total residues of cyprodinil and CGA-249287.  The cancer/chronic EDWC in surface waters is 16.4 μg/L for the total residues of cyprodinil and CGA-249287.  All surface waters EDWCs were obtained using the New York grapes PRZM scenario.  The PRZM-GW generated EDWC for the use on grapes, using the FL citrus surrogate scenario were 2.05 μg/L for the total residues of cyprodinil and CGA-249287 (acute) and 1.80 μg/L for the total residues (chronic).  For details on methods, characterization of results, uncertainties, etc., please, refer to the previous DWAs. Table 3 provides a summary of the Tier 2 modeled drinking water concentrations.

Table 3.  Maximum Estimated Drinking Water Concentrations for the Use of Cyprodinil (expressed as total residues of cyprodinil plus its degradate CGA-249287)

DRINKING WATER SOURCE (MODEL USED) 	USE (rate modeled per year)	MAXIMUM ESTIMATED DRINKING WATER CONCENTRATION  (EDWC)  ( ppb)

Groundwater (PRZM-GW)	FL citrus1 (1.4 lb a.i.)	Acute	2.05

Chronic	1.80

Surface water

(PRZM/EXAMS)	NY grapes (1.4 lb a.i.)	Acute	34.8

Chronic	24.7

Cancer/Chronic	16.4

1 Scenario was used as a surrogate and run with the maximum application rate for grapes.

V.	DEEM-FCID Program and Consumption Information

Cyprodinil acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID, Version 3.18, which incorporates consumption data from USDA’s National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA).  This dietary survey was conducted from 2003 to 2008.  The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form.  The resulting residue consumption estimate for each food/food form is summed with the residue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, for Tiers 1 and 2, significant differences in user vs. per capita exposure and risk are identified and noted in the risk assessment.

VI.	Toxicological Information

HED evaluated the toxicology data base for cyprodinil and selected doses and endpoints for  chronic dietary and drinking water risk assessments provided in Table 4.

Table 4. Summary of Toxicological Doses and Endpoints for Cyprodinil  for Use in Dietary Human Health Risk Assessments

Exposure/Scenario	Point of Departure	Uncertainty/FQPA Safety Factors RfD, PAD, LOC for Risk Assessment	Study and Toxicological Effects

Acute Dietary

(All Populations)

NOAEL = 200 mg/kg/day

UFA= 10x

UFH=10x

FQPA SF= 1x

Acute RfD = 2.0 mg/kg/day           aPAD = 2.0 mg/kg/day

	Acute Neurotoxicity - Rat

LOAEL = 600 mg/kg/day based on clinical signs of toxicity, low motor activity and reversible hypothermia

Chronic Dietary

(All Populations)	NOAEL= 2.7 mg/kg/day	UFA = 10x

UFH =10x

FQPA SF= 1x	Chronic RfD = 0.027

mg/kg/day

cPAD = 0.027mg/kg/day	2-Year Chronic Toxicity/ Carcinogenicity- rat

LOAEL = 35.6 mg/kg/day based on degenerative liver lesions (spongiosis hepatis) in males.

Cancer (all routes)	Classification: “Not likely to be carcinogenic to humans”

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and  used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures.

NOAEL = no observed adverse effect level.

LOAEL = lowest observed adverse effect level.

UF = uncertainty factor.

UFA = extrapolation from animal to human (interspecies).

UFH = potential variation in sensitivity among members of the human population (intraspecies).

FQPA SF = FQPA Safety Factor.

PAD = population adjusted dose (a = acute, c = chronic).

RfD = reference dose.

VII.	Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™ analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in Tables 5 & 6 are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years.

Results of Acute Dietary Exposure Analysis

The results of the acute dietary exposure analysis are reported in Table 5.

Table 5:  Summary of Acute Dietary Exposure and Risk for Cyprodinil

Population Subgroup	aPAD (mg/kg/day)	Acute (95th Percentile)

Exposure (mg/kg/day)	%aPAD

General U.S. Population	2.0	0.095198	4.8

All Infants (< 1 year old)

0.101588	5.1

Children 1-2 years old

0.172629	8.6

Children 3-5 years old

0.158663	7.9

Children 6-12 years old

0.083374	4.2

Youth 13-19 years old

0.071553	3.6

Adults 20-49 years old

0.091866	4.6

Adults 50+ years old

0.091595	4.6

Females 13-49 years old

0.096706	4.8

The bolded %aPAD is the highest.

Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in Table 6.

Table 6:  Summary of Chronic Dietary Exposure and Risk for Cyprodinil

Population Subgroup	cPAD (mg/kg/day)	Chronic

Exposure (mg/kg/day)	% cPAD

General U.S. Population	0.027	0.007794	29

All Infants (< 1 year old)

0.013042	48

Children 1-2 years old

0.023045	85

Children 3-5 years old

0.016592	62

Children 6-12 years old

0.008522	32

Youth 13-19 years old

0.004665	17

Adults 20-49 years old

0.006327	23

Adults 50+ years old

0.007772	29

Females 13-49 years old

0.006706	25

The bolded %cPAD is the highest.

VIII.	Characterization of Inputs/Outputs

For the acute dietary analysis, tolerance level residues and 100% crop treated assumptions were used for all treated commodities.  For the chronic dietary analysis, tolerance level residues for most commodities; average field trial residues for pome fruit, head lettuce, leaf lettuce, spinach, tomatoes, lemon, and grapes; and 100% crop treated assumptions were used.  Default processing factors were used for all processed commodities except tomato paste/puree (1x) and lemon/lime juice (1x).  Risk drivers are celery, pome fruit, and strawberry.  Residues do not warrant further refinement at this time.

IX.	Conclusions

An acute and chronic dietary exposure analyses was performed for the general U.S. population and various population subgroups.  The acute and chronic risk estimates are below HED’s level of concern.  HED is confident the acute and chronic dietary exposures to cyprodinil are not underestimated.

X.  List of Attachments

1.  Acute DEEM-FCID Residue Input File.

2.  Results of Acute DEEM-FCID Dietary Exposure Analysis.

3.  Chronic DEEM-FCID Residue Input File.

4.  Results of Chronic DEEM-FCID Dietary Exposure Analysis.

Attachment 1 Acute DEEM-FCID Residue Input File

Filename: C:\Users\tmorton\Documents\My Files\DEEM Files\288202 Cyprodinil\Cyprodinil 4E8273\288202ACUTEEPARECOMMENDATIONS PLUS 13-07F CODEX HARM.R08

Chemical: cyprodinil

RfD(Chronic): .03 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 2 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 04-09-2015/09:37:24       Program ver. 3.16, 03-08-d

------------------------------------------------------------------------ -----------

   EPA     Crop                                   Def Res     Adj.Factors   Comment

   Code     Grp  Commodity Name                    (ppm)       #1    #2

---------- ---- -------------------------------  ----------  ------ ------  -------

0101050000 1AB  Beet, garden, roots                0.750000   1.000  1.000

0101050001 1AB  Beet, garden, roots-babyfood       0.750000   1.000  1.000

0101067000 1AB  Burdock                            0.750000   1.000  1.000

0101078000 1AB  Carrot                             0.750000   1.000  1.000

0101078001 1AB  Carrot-babyfood                    0.750000   1.000  1.000

0101079000 1AB  Carrot, juice                      0.750000   1.000  1.000

0101084000 1AB  Celeriac                           0.750000   1.000  1.000

0101100000 1AB  Chicory, roots                     0.750000   1.000  1.000

0101168000 1AB  Ginseng, dried                     0.750000   1.000  1.000

0101190000 1AB  Horseradish                        0.750000   1.000  1.000

0101250000 1AB  Parsley, turnip rooted             0.750000   1.000  1.000

0101251000 1AB  Parsnip                            0.750000   1.000  1.000

0101251001 1AB  Parsnip-babyfood                   0.750000   1.000  1.000

0101314000 1AB  Radish, roots                      0.750000   1.000  1.000

0101316000 1AB  Radish, Oriental, roots            0.750000   1.000  1.000

0101327000 1AB  Rutabaga                           0.750000   1.000  1.000

0101331000 1AB  Salsify, roots                     0.750000   1.000  1.000

0101388000 1AB  Turnip, roots                      0.750000   1.000  1.000

0200051000 2    Beet, garden, tops                10.000000   1.000  1.000

0200101000 2    Chicory, tops                     10.000000   1.000  1.000

0200140000 2    Dasheen, leaves                   10.000000   1.000  1.000

0200315000 2    Radish, tops                      10.000000   1.000  1.000

0200317000 2    Radish, Oriental, tops            10.000000   1.000  1.000

0200332000 2    Salsify, tops                     10.000000   1.000  1.000

0301165000 3A   Garlic, bulb                       0.600000   1.000  1.000

0301165001 3A   Garlic, bulb-babyfood              0.600000   1.000  1.000

0301237000 3A   Onion, bulb                        0.600000   1.000  1.000

0301237001 3A   Onion, bulb-babyfood               0.600000   1.000  1.000

0301238000 3A   Onion, bulb, dried                 0.600000   9.000  1.000

0301238001 3A   Onion, bulb, dried-babyfood        0.600000   9.000  1.000

0301338000 3A   Shallot, bulb                      0.600000   1.000  1.000

0302103000 3B   Chive, fresh leaves                3.000000   1.000  1.000

0302198000 3B   Leek                               4.000000   1.000  1.000

0302239000 3B   Onion, green                       4.000000   1.000  1.000

0302338500 3B   Shallot, fresh leaves              4.000000   1.000  1.000

0401005000 4A   Amaranth, leafy                   50.000000   1.000  1.000

0401018000 4A   Arugula                           50.000000   1.000  1.000

0401104000 4A   Chrysanthemum, garland            50.000000   1.000  1.000

0401133000 4A   Cress, garden                     50.000000   1.000  1.000

0401134000 4A   Cress, upland                     50.000000   1.000  1.000

0401138000 4A   Dandelion, leaves                 50.000000   1.000  1.000

0401150000 4A   Endive                            50.000000   1.000  1.000

0401204000 4A   Lettuce, head                     50.000000   1.000  1.000

0401205000 4A   Lettuce, leaf                     50.000000   1.000  1.000

0401248000 4A   Parsley, leaves                   50.000000   1.000  1.000

0401313000 4A   Radicchio                         50.000000   1.000  1.000

0401355000 4A   Spinach                           50.000000   1.000  1.000

0401355001 4A   Spinach-babyfood                  50.000000   1.000  1.000

0402076000 4B   Cardoon                           30.000000   1.000  1.000

0402085000 4B   Celery                            30.000000   1.000  1.000

0402085001 4B   Celery-babyfood                   30.000000   1.000  1.000

0402086000 4B   Celery, juice                     30.000000   1.000  1.000

0402087000 4B   Celtuce                           30.000000   1.000  1.000

0402152000 4B   Fennel, Florence                  30.000000   1.000  1.000

0402322000 4B   Rhubarb                           30.000000   1.000  1.000

0402367000 4B   Swiss chard                       30.000000   1.000  1.000

0501061000 5A   Broccoli                           1.000000   1.000  1.000

0501061001 5A   Broccoli-babyfood                  1.000000   1.000  1.000

0501062000 5A   Broccoli, Chinese                  1.000000   1.000  1.000

0501064000 5A   Brussels sprouts                   1.000000   1.000  1.000

0501069000 5A   Cabbage                            1.000000   1.000  1.000

0501071000 5A   Cabbage, Chinese, napa             1.000000   1.000  1.000

0501072000 5A   Cabbage, Chinese, mustard          1.000000   1.000  1.000

0501083000 5A   Cauliflower                        1.000000   1.000  1.000

0501196000 5A   Kohlrabi                           1.000000   1.000  1.000

0502063000 5B   Broccoli raab                     10.000000   1.000  1.000

0502070000 5B   Cabbage, Chinese, bok choy        10.000000   1.000  1.000

0502117000 5B   Collards                          10.000000   1.000  1.000

0502194000 5B   Kale                              10.000000   1.000  1.000

0502229000 5B   Mustard greens                    10.000000   1.000  1.000

0502318000 5B   Rape greens                       10.000000   1.000  1.000

0502389000 5B   Turnip, greens                    10.000000   1.000  1.000

0602031000 6B   Bean, broad, succulent             0.600000   1.000  1.000

0602033000 6B   Bean, cowpea, succulent            0.600000   1.000  1.000

0602037000 6B   Bean, lima, succulent              0.600000   1.000  1.000

0603030000 6C   Bean, black, seed                  0.600000   1.000  1.000

0603032000 6C   Bean, broad, seed                  0.600000   1.000  1.000

0603034000 6C   Bean, cowpea, seed                 0.600000   1.000  1.000

0603035000 6C   Bean,  great northern, seed        0.600000   1.000  1.000

0603036000 6C   Bean, kidney, seed                 0.600000   1.000  1.000

0603038000 6C   Bean, lima, seed                   0.600000   1.000  1.000

0603039000 6C   Bean, mung, seed                   0.600000   1.000  1.000

0603040000 6C   Bean, navy, seed                   0.600000   1.000  1.000

0603041000 6C   Bean, pink, seed                   0.600000   1.000  1.000

0603042000 6C   Bean, pinto, seed                  0.600000   1.000  1.000

0603098000 6C   Chickpea, seed                     0.600000   1.000  1.000

0603098001 6C   Chickpea, seed-babyfood            0.600000   1.000  1.000

0603099000 6C   Chickpea, flour                    0.600000   1.000  1.000

0603182000 6C   Guar, seed                         0.600000   1.000  1.000

0603182001 6C   Guar, seed-babyfood                0.600000   1.000  1.000

0603203000 6C   Lentil, seed                       0.600000   1.000  1.000

0801374000 8A   Tomatillo                          1.500000   1.000  1.000

0801375000 8A   Tomato                             1.500000   1.000  1.000

0801375001 8A   Tomato-babyfood                    1.500000   1.000  1.000

0801376000 8A   Tomato, paste                      1.500000   1.000  1.000

0801376001 8A   Tomato, paste-babyfood             1.500000   1.000  1.000

0801377000 8A   Tomato, puree                      1.500000   1.000  1.000

0801377001 8A   Tomato, puree-babyfood             1.500000   1.000  1.000

0801378000 8A   Tomato, dried                      1.500000  14.300  1.000

0801378001 8A   Tomato, dried-babyfood             1.500000  14.300  1.000

0801379000 8A   Tomato, juice                      1.500000   1.000  1.000

0801380000 8A   Tomato, Tree                       1.500000   1.000  1.000

0802148000 8BC  Eggplant                           1.500000   1.000  1.000

0802234000 8BC  Okra                               1.500000   1.000  1.000

0802270000 8B   Pepper, bell                       1.500000   1.000  1.000

0802270001 8B   Pepper, bell-babyfood              1.500000   1.000  1.000

0802271000 8B   Pepper, bell, dried                1.500000   1.000  1.000

0802271001 8B   Pepper, bell, dried-babyfood       1.500000   1.000  1.000

0802272000 8BC  Pepper, nonbell                    1.500000   1.000  1.000

0802272001 8BC  Pepper, nonbell-babyfood           1.500000   1.000  1.000

0802273000 8BC  Pepper, nonbell, dried             1.500000   1.000  1.000

0901075000 9A   Cantaloupe                         0.700000   1.000  1.000

0901187000 9A   Honeydew melon                     0.700000   1.000  1.000

0901399000 9A   Watermelon                         0.700000   1.000  1.000

0901400000 9A   Watermelon, juice                  0.700000   1.000  1.000

0902021000 9B   Balsam pear                        0.700000   1.000  1.000

0902088000 9B   Chayote, fruit                     0.700000   1.000  1.000

0902102000 9B   Chinese waxgourd                   0.700000   1.000  1.000

0902135000 9B   Cucumber                           0.700000   1.000  1.000

0902308000 9B   Pumpkin                            0.700000   1.000  1.000

0902309000 9B   Pumpkin, seed                      0.700000   1.000  1.000

0902356000 9B   Squash, summer                     0.700000   1.000  1.000

0902356001 9B   Squash, summer-babyfood            0.700000   1.000  1.000

0902357000 9B   Squash, winter                     0.700000   1.000  1.000

0902357001 9B   Squash, winter-babyfood            0.700000   1.000  1.000

1001108000 10A  Citrus, oil                       60.000000   1.000  1.000

1002199000 10B  Lemon                              0.600000   1.000  1.000

1002200000 10B  Lemon, juice                       0.600000   1.000  1.000

1002200001 10B  Lemon, juice-babyfood              0.600000   1.000  1.000

1002201000 10B  Lemon, peel                        0.600000   1.000  1.000

1002206000 10B  Lime                               0.600000   1.000  1.000

1002207000 10B  Lime, juice                        0.600000   1.000  1.000

1002207001 10B  Lime, juice-babyfood               0.600000   1.000  1.000

1100007000 11   Apple, fruit with peel             1.700000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100008000 11   Apple, peeled fruit                1.700000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100008001 11   Apple, peeled fruit-babyfood       1.700000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100009000 11   Apple, dried                       1.700000   8.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100009001 11   Apple, dried-babyfood              1.700000   8.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100010000 11   Apple, juice                       1.700000   1.300  1.000  PP#0F7

            Full comment: PP#0F7696

1100010001 11   Apple, juice-babyfood              1.700000   1.300  1.000  PP#0F7

            Full comment: PP#0F7696

1100011000 11   Apple, sauce                       1.700000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100011001 11   Apple, sauce-babyfood              1.700000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100129000 11   Crabapple                          1.700000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100173500 11   Goji berry                         1.500000   1.000  1.000

1100210000 11   Loquat                             1.700000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100266000 11   Pear                               1.700000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100266001 11   Pear-babyfood                      1.700000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100267000 11   Pear, dried                        1.700000   6.250  1.000  PP#0F7

            Full comment: PP#0F7696

1100268000 11   Pear, juice                        1.700000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100268001 11   Pear, juice-babyfood               1.700000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100310000 11   Quince                             1.700000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1201090000 12A  Cherry                             2.000000   1.000  1.000

1201090001 12A  Cherry-babyfood                    2.000000   1.000  1.000

1201091000 12A  Cherry, juice                      2.000000   1.500  1.000

1201091001 12A  Cherry, juice-babyfood             2.000000   1.500  1.000

1202012000 12B  Apricot                            2.000000   1.000  1.000

1202012001 12B  Apricot-babyfood                   2.000000   1.000  1.000

1202013000 12B  Apricot, dried                     2.000000   6.000  1.000

1202014000 12B  Apricot, juice                     2.000000   1.000  1.000

1202014001 12B  Apricot, juice-babyfood            2.000000   1.000  1.000

1202230000 12B  Nectarine                          2.000000   1.000  1.000

1202260000 12B  Peach                              2.000000   1.000  1.000

1202260001 12B  Peach-babyfood                     2.000000   1.000  1.000

1202261000 12B  Peach, dried                       2.000000   7.000  1.000

1202261001 12B  Peach, dried-babyfood              2.000000   7.000  1.000

1202262000 12B  Peach, juice                       2.000000   1.000  1.000

1202262001 12B  Peach, juice-babyfood              2.000000   1.000  1.000

1203285000 12C  Plum                               2.000000   1.000  1.000

1203285001 12C  Plum-babyfood                      2.000000   1.000  1.000

1203286000 12C  Plum, prune, fresh                 2.000000   1.000  1.000

1203286001 12C  Plum, prune, fresh-babyfood        2.000000   1.000  1.000

1203287000 12C  Plum, prune, dried                 2.000000   5.000  1.000

1203287001 12C  Plum, prune, dried-babyfood        2.000000   5.000  1.000

1203288000 12C  Plum, prune, juice                 2.000000   1.400  1.000

1203288001 12C  Plum, prune, juice-babyfood        2.000000   1.400  1.000

1301055000 13A  Blackberry                        10.000000   1.000  1.000

1301056000 13A  Blackberry, juice                 10.000000   1.000  1.000

1301056001 13A  Blackberry, juice-babyfood        10.000000   1.000  1.000

1301058000 13A  Boysenberry                       10.000000   1.000  1.000

1301208000 13A  Loganberry                        10.000000   1.000  1.000

1301320000 13A  Raspberry                         10.000000   1.000  1.000

1301320001 13A  Raspberry-babyfood                10.000000   1.000  1.000

1301321000 13A  Raspberry, juice                  10.000000   1.000  1.000

1301321001 13A  Raspberry, juice-babyfood         10.000000   1.000  1.000

1302057000 13B  Blueberry                          3.000000   1.000  1.000

1302057001 13B  Blueberry-babyfood                 3.000000   1.000  1.000

1302136000 13B  Currant                            3.000000   1.000  1.000

1302137000 13B  Currant, dried                     3.000000   1.000  1.000

1302149000 13B  Elderberry                         3.000000   1.000  1.000

1302174000 13B  Gooseberry                         3.000000   1.000  1.000

1302191000 13B  Huckleberry                        3.000000   1.000  1.000

1304175000 13D  Grape                              3.000000   1.000  1.000

1304176000 13D  Grape, juice                       3.000000   1.200  1.000

1304176001 13D  Grape, juice-babyfood              3.000000   1.200  1.000

1304179000 13D  Grape, wine and sherry             3.000000   1.000  1.000

1304195000 13D  Kiwifruit, fuzzy                   1.800000   1.000  1.000

1307359000 13G  Strawberry                         5.000000   1.000  1.000

1307359001 13G  Strawberry-babyfood                5.000000   1.000  1.000

1307360000 13G  Strawberry, juice                  5.000000   1.000  1.000

1307360001 13G  Strawberry, juice-babyfood         5.000000   1.000  1.000

1400003000 14   Almond                             0.020000   1.000  1.000

1400003001 14   Almond-babyfood                    0.020000   1.000  1.000

1400004000 14   Almond, oil                        0.020000   1.000  1.000

1400004001 14   Almond, oil-babyfood               0.020000   1.000  1.000

1400282000 14   Pistachio                          0.100000   1.000  1.000

1901028000 19A  Basil, fresh leaves                3.000000   1.000  1.000

1901028001 19A  Basil, fresh leaves-babyfood       3.000000   1.000  1.000

1901029000 19A  Basil, dried leaves               15.000000   1.000  1.000

1901029001 19A  Basil, dried leaves-babyfood      15.000000   1.000  1.000

1901102500 19A  Chive, dried leaves               15.000000   1.000  1.000

1901118000 19A  Cilantro, leaves                   3.000000   1.000  1.000

1901118001 19A  Cilantro, leaves-babyfood          3.000000   1.000  1.000

1901144000 19A  Dillweed                           3.000000   1.000  1.000

1901184000 19A  Herbs, other                       3.000000   1.000  1.000

1901184001 19A  Herbs, other-babyfood              3.000000   1.000  1.000

1901202000 19A  Lemongrass                         3.000000   1.000  1.000

1901220000 19A  Marjoram                           3.000000   1.000  1.000

1901220001 19A  Marjoram-babyfood                  3.000000   1.000  1.000

1901249000 19A  Parsley, dried leaves            170.000000   1.000  1.000

1901249001 19A  Parsley, dried leaves-babyfood   170.000000   1.000  1.000

1901334000 19A  Savory                             3.000000   1.000  1.000

2001319000 20A  Rapeseed, oil                      0.030000   1.000  1.000

2001319001 20A  Rapeseed, oil-babyfood             0.030000   1.000  1.000

3100046000 31   Beef, meat byproducts              0.020000   1.000  1.000

3100046001 31   Beef, meat byproducts-babyfood     0.020000   1.000  1.000

3100048000 31   Beef, kidney                       0.020000   1.000  1.000

3100049000 31   Beef, liver                        0.020000   1.000  1.000

3100049001 31   Beef, liver-babyfood               0.020000   1.000  1.000

3200170000 32   Goat, meat byproducts              0.020000   1.000  1.000

3200172000 32   Goat, kidney                       0.020000   1.000  1.000

3200173000 32   Goat, liver                        0.020000   1.000  1.000

3500340000 35   Sheep, meat byproducts             0.020000   1.000  1.000

3500342000 35   Sheep, kidney                      0.020000   1.000  1.000

3500343000 35   Sheep, liver                       0.020000   1.000  1.000

8601000000 86A  Water, direct, all sources         0.034790   1.000  1.000

8602000000 86B  Water, indirect, all sources       0.034790   1.000  1.000

9500001000 O    Acerola                            1.500000   1.000  1.000

9500016000 O    Artichoke, globe                   4.000000   1.000  1.000

9500020000 O    Avocado                            1.200000   1.000  1.000

9500074000 O    Canistel                           1.200000   1.000  1.000

9500151000 O    Feijoa                             1.500000   1.000  1.000

9500177000 O    Grape, leaves                      3.000000   1.000  1.000

9500178000 O    Grape, raisin                      5.000000   1.000  1.000

9500183000 O    Guava                              1.500000   1.000  1.000

9500183001 O    Guava-babyfood                     1.500000   1.000  1.000

9500209000 O    Longan                             2.000000   1.000  1.000

9500211000 O    Lychee                             2.000000   1.000  1.000

9500212000 O    Lychee, dried                      2.000000   1.850  1.000

9500215000 O    Mango                              1.200000   1.000  1.000

9500215001 O    Mango-babyfood                     1.200000   1.000  1.000

9500216000 O    Mango, dried                       1.200000   1.000  1.000

9500217000 O    Mango, juice                       1.200000   1.000  1.000

9500217001 O    Mango, juice-babyfood              1.200000   1.000  1.000

9500245000 O    Papaya                             1.200000   1.000  1.000

9500245001 O    Papaya-babyfood                    1.200000   1.000  1.000

9500246000 O    Papaya, dried                      1.200000   1.800  1.000

9500247000 O    Papaya, juice                      1.200000   1.500  1.000

9500252000 O    Passionfruit                       1.500000   1.000  1.000

9500252001 O    Passionfruit-babyfood              1.500000   1.000  1.000

9500253000 O    Passionfruit, juice                1.500000   1.000  1.000

9500253001 O    Passionfruit, juice-babyfood       1.500000   1.000  1.000

9500289000 O    Pomegranate                       10.000000   1.000  1.000

9500333000 O    Sapote, Mamey                      1.200000   1.000  1.000

9500351000 O    Spanish lime                       2.000000   1.000  1.000

9500358000 O    Starfruit                          1.500000   1.000  1.000

9500398000 O    Watercress                        20.000000   1.000  1.000

Attachment 2 Chronic DEEM-FCID Residue Input File

Filename: C:\Users\tmorton\Documents\My Files\DEEM Files\288202 Cyprodinil\Cyprodinil 4E8273\288202CHRONICEPARECOMMENDATIONS.R08

Chemical: cyprodinil

RfD(Chronic): .03 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 1.5 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 04-09-2015/09:10:28       Program ver. 3.16, 03-08-d

------------------------------------------------------------------------ -----------

   EPA     Crop                                   Def Res     Adj.Factors   Comment

   Code     Grp  Commodity Name                    (ppm)       #1    #2

---------- ---- -------------------------------  ----------  ------ ------  -------

0101050000 1AB  Beet, garden, roots                0.750000   1.000  1.000

0101050001 1AB  Beet, garden, roots-babyfood       0.750000   1.000  1.000

0101067000 1AB  Burdock                            0.750000   1.000  1.000

0101078000 1AB  Carrot                             0.750000   1.000  1.000

0101078001 1AB  Carrot-babyfood                    0.750000   1.000  1.000

0101079000 1AB  Carrot, juice                      0.750000   1.000  1.000

0101084000 1AB  Celeriac                           0.750000   1.000  1.000

0101100000 1AB  Chicory, roots                     0.750000   1.000  1.000

0101168000 1AB  Ginseng, dried                     0.750000   1.000  1.000

0101190000 1AB  Horseradish                        0.750000   1.000  1.000

0101250000 1AB  Parsley, turnip rooted             0.750000   1.000  1.000

0101251000 1AB  Parsnip                            0.750000   1.000  1.000

0101251001 1AB  Parsnip-babyfood                   0.750000   1.000  1.000

0101314000 1AB  Radish, roots                      0.750000   1.000  1.000

0101316000 1AB  Radish, Oriental, roots            0.750000   1.000  1.000

0101327000 1AB  Rutabaga                           0.750000   1.000  1.000

0101331000 1AB  Salsify, roots                     0.750000   1.000  1.000

0101388000 1AB  Turnip, roots                      0.750000   1.000  1.000

0200051000 2    Beet, garden, tops                10.000000   1.000  1.000

0200101000 2    Chicory, tops                     10.000000   1.000  1.000

0200140000 2    Dasheen, leaves                   10.000000   1.000  1.000

0200315000 2    Radish, tops                      10.000000   1.000  1.000

0200317000 2    Radish, Oriental, tops            10.000000   1.000  1.000

0200332000 2    Salsify, tops                     10.000000   1.000  1.000

0301165000 3A   Garlic, bulb                       0.600000   1.000  1.000

0301165001 3A   Garlic, bulb-babyfood              0.600000   1.000  1.000

0301237000 3A   Onion, bulb                        0.600000   1.000  1.000

0301237001 3A   Onion, bulb-babyfood               0.600000   1.000  1.000

0301238000 3A   Onion, bulb, dried                 0.600000   9.000  1.000

0301238001 3A   Onion, bulb, dried-babyfood        0.600000   9.000  1.000

0301338000 3A   Shallot, bulb                      0.600000   1.000  1.000

0302103000 3B   Chive, fresh leaves                3.000000   1.000  1.000

0302198000 3B   Leek                               4.000000   1.000  1.000

0302239000 3B   Onion, green                       4.000000   1.000  1.000

0302338500 3B   Shallot, fresh leaves              4.000000   1.000  1.000

0401005000 4A   Amaranth, leafy                   50.000000   1.000  1.000

0401018000 4A   Arugula                           50.000000   1.000  1.000

0401104000 4A   Chrysanthemum, garland            50.000000   1.000  1.000

0401133000 4A   Cress, garden                     50.000000   1.000  1.000

0401134000 4A   Cress, upland                     50.000000   1.000  1.000

0401138000 4A   Dandelion, leaves                 50.000000   1.000  1.000

0401150000 4A   Endive                            50.000000   1.000  1.000

0401204000 4A   Lettuce, head                      0.870000   1.000  1.000

0401205000 4A   Lettuce, leaf                     13.000000   1.000  1.000

0401248000 4A   Parsley, leaves                   35.000000   1.000  1.000

0401313000 4A   Radicchio                         50.000000   1.000  1.000

0401355000 4A   Spinach                           11.800000   1.000  1.000

0401355001 4A   Spinach-babyfood                  11.800000   1.000  1.000

0402076000 4B   Cardoon                           30.000000   1.000  1.000

0402085000 4B   Celery                            30.000000   1.000  1.000

0402085001 4B   Celery-babyfood                   30.000000   1.000  1.000

0402086000 4B   Celery, juice                     30.000000   1.000  1.000

0402087000 4B   Celtuce                           30.000000   1.000  1.000

0402152000 4B   Fennel, Florence                  30.000000   1.000  1.000

0402322000 4B   Rhubarb                           30.000000   1.000  1.000

0402367000 4B   Swiss chard                       30.000000   1.000  1.000

0501061000 5A   Broccoli                           1.000000   1.000  1.000

0501061001 5A   Broccoli-babyfood                  1.000000   1.000  1.000

0501062000 5A   Broccoli, Chinese                  1.000000   1.000  1.000

0501064000 5A   Brussels sprouts                   1.000000   1.000  1.000

0501069000 5A   Cabbage                            1.000000   1.000  1.000

0501071000 5A   Cabbage, Chinese, napa             1.000000   1.000  1.000

0501072000 5A   Cabbage, Chinese, mustard          1.000000   1.000  1.000

0501083000 5A   Cauliflower                        1.000000   1.000  1.000

0501196000 5A   Kohlrabi                           1.000000   1.000  1.000

0502063000 5B   Broccoli raab                     10.000000   1.000  1.000

0502070000 5B   Cabbage, Chinese, bok choy        10.000000   1.000  1.000

0502117000 5B   Collards                          10.000000   1.000  1.000

0502194000 5B   Kale                              10.000000   1.000  1.000

0502229000 5B   Mustard greens                    10.000000   1.000  1.000

0502318000 5B   Rape greens                       10.000000   1.000  1.000

0502389000 5B   Turnip, greens                    10.000000   1.000  1.000

0602031000 6B   Bean, broad, succulent             0.600000   1.000  1.000

0602033000 6B   Bean, cowpea, succulent            0.600000   1.000  1.000

0602037000 6B   Bean, lima, succulent              0.600000   1.000  1.000

0603030000 6C   Bean, black, seed                  0.600000   1.000  1.000

0603032000 6C   Bean, broad, seed                  0.600000   1.000  1.000

0603034000 6C   Bean, cowpea, seed                 0.600000   1.000  1.000

0603035000 6C   Bean,  great northern, seed        0.600000   1.000  1.000

0603036000 6C   Bean, kidney, seed                 0.600000   1.000  1.000

0603038000 6C   Bean, lima, seed                   0.600000   1.000  1.000

0603039000 6C   Bean, mung, seed                   0.600000   1.000  1.000

0603040000 6C   Bean, navy, seed                   0.600000   1.000  1.000

0603041000 6C   Bean, pink, seed                   0.600000   1.000  1.000

0603042000 6C   Bean, pinto, seed                  0.600000   1.000  1.000

0603098000 6C   Chickpea, seed                     0.600000   1.000  1.000

0603098001 6C   Chickpea, seed-babyfood            0.600000   1.000  1.000

0603099000 6C   Chickpea, flour                    0.600000   1.000  1.000

0603182000 6C   Guar, seed                         0.600000   1.000  1.000

0603182001 6C   Guar, seed-babyfood                0.600000   1.000  1.000

0603203000 6C   Lentil, seed                       0.600000   1.000  1.000

0801374000 8A   Tomatillo                          0.160000   1.000  1.000

0801375000 8A   Tomato                             0.160000   1.000  1.000

0801375001 8A   Tomato-babyfood                    0.160000   1.000  1.000

0801376000 8A   Tomato, paste                      0.160000   1.000  1.000

0801376001 8A   Tomato, paste-babyfood             0.160000   1.000  1.000

0801377000 8A   Tomato, puree                      0.160000   1.000  1.000

0801377001 8A   Tomato, puree-babyfood             0.160000   1.000  1.000

0801378000 8A   Tomato, dried                      0.160000  14.300  1.000

0801378001 8A   Tomato, dried-babyfood             0.160000  14.300  1.000

0801379000 8A   Tomato, juice                      0.160000   1.000  1.000

0801380000 8A   Tomato, Tree                       0.160000   1.000  1.000

0802148000 8BC  Eggplant                           1.500000   1.000  1.000

0802234000 8BC  Okra                               1.500000   1.000  1.000

0802270000 8B   Pepper, bell                       1.500000   1.000  1.000

0802270001 8B   Pepper, bell-babyfood              1.500000   1.000  1.000

0802271000 8B   Pepper, bell, dried                1.500000   1.000  1.000

0802271001 8B   Pepper, bell, dried-babyfood       1.500000   1.000  1.000

0802272000 8BC  Pepper, nonbell                    1.500000   1.000  1.000

0802272001 8BC  Pepper, nonbell-babyfood           1.500000   1.000  1.000

0802273000 8BC  Pepper, nonbell, dried             1.500000   1.000  1.000

0901075000 9A   Cantaloupe                         0.700000   1.000  1.000

0901187000 9A   Honeydew melon                     0.700000   1.000  1.000

0901399000 9A   Watermelon                         0.700000   1.000  1.000

0901400000 9A   Watermelon, juice                  0.700000   1.000  1.000

0902021000 9B   Balsam pear                        0.700000   1.000  1.000

0902088000 9B   Chayote, fruit                     0.700000   1.000  1.000

0902102000 9B   Chinese waxgourd                   0.700000   1.000  1.000

0902135000 9B   Cucumber                           0.700000   1.000  1.000

0902308000 9B   Pumpkin                            0.700000   1.000  1.000

0902309000 9B   Pumpkin, seed                      0.700000   1.000  1.000

0902356000 9B   Squash, summer                     0.700000   1.000  1.000

0902356001 9B   Squash, summer-babyfood            0.700000   1.000  1.000

0902357000 9B   Squash, winter                     0.700000   1.000  1.000

0902357001 9B   Squash, winter-babyfood            0.700000   1.000  1.000

1001108000 10A  Citrus, oil                       60.000000   1.000  1.000

1002199000 10B  Lemon                              0.260000   1.000  1.000

1002200000 10B  Lemon, juice                       0.260000   1.000  1.000

1002200001 10B  Lemon, juice-babyfood              0.260000   1.000  1.000

1002201000 10B  Lemon, peel                        0.260000   1.000  1.000

1002206000 10B  Lime                               0.260000   1.000  1.000

1002207000 10B  Lime, juice                        0.260000   1.000  1.000

1002207001 10B  Lime, juice-babyfood               0.260000   1.000  1.000

1100007000 11   Apple, fruit with peel             0.500000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100008000 11   Apple, peeled fruit                0.500000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100008001 11   Apple, peeled fruit-babyfood       0.500000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100009000 11   Apple, dried                       0.500000   8.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100009001 11   Apple, dried-babyfood              0.500000   8.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100010000 11   Apple, juice                       0.500000   1.300  1.000  PP#0F7

            Full comment: PP#0F7696

1100010001 11   Apple, juice-babyfood              0.500000   1.300  1.000  PP#0F7

            Full comment: PP#0F7696

1100011000 11   Apple, sauce                       0.500000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100011001 11   Apple, sauce-babyfood              0.500000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100129000 11   Crabapple                          0.500000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100173500 11   Goji berry                         1.500000   1.000  1.000

1100210000 11   Loquat                             0.500000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100266000 11   Pear                               0.380000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100266001 11   Pear-babyfood                      0.380000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100267000 11   Pear, dried                        0.380000   6.250  1.000  PP#0F7

            Full comment: PP#0F7696

1100268000 11   Pear, juice                        0.380000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100268001 11   Pear, juice-babyfood               0.380000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1100310000 11   Quince                             0.500000   1.000  1.000  PP#0F7

            Full comment: PP#0F7696

1201090000 12A  Cherry                             2.000000   1.000  1.000

1201090001 12A  Cherry-babyfood                    2.000000   1.000  1.000

1201091000 12A  Cherry, juice                      2.000000   1.500  1.000

1201091001 12A  Cherry, juice-babyfood             2.000000   1.500  1.000

1202012000 12B  Apricot                            2.000000   1.000  1.000

1202012001 12B  Apricot-babyfood                   2.000000   1.000  1.000

1202013000 12B  Apricot, dried                     2.000000   6.000  1.000

1202014000 12B  Apricot, juice                     2.000000   1.000  1.000

1202014001 12B  Apricot, juice-babyfood            2.000000   1.000  1.000

1202230000 12B  Nectarine                          2.000000   1.000  1.000

1202260000 12B  Peach                              2.000000   1.000  1.000

1202260001 12B  Peach-babyfood                     2.000000   1.000  1.000

1202261000 12B  Peach, dried                       2.000000   7.000  1.000

1202261001 12B  Peach, dried-babyfood              2.000000   7.000  1.000

1202262000 12B  Peach, juice                       2.000000   1.000  1.000

1202262001 12B  Peach, juice-babyfood              2.000000   1.000  1.000

1203285000 12C  Plum                               2.000000   1.000  1.000

1203285001 12C  Plum-babyfood                      2.000000   1.000  1.000

1203286000 12C  Plum, prune, fresh                 2.000000   1.000  1.000

1203286001 12C  Plum, prune, fresh-babyfood        2.000000   1.000  1.000

1203287000 12C  Plum, prune, dried                 2.000000   5.000  1.000

1203287001 12C  Plum, prune, dried-babyfood        2.000000   5.000  1.000

1203288000 12C  Plum, prune, juice                 2.000000   1.400  1.000

1203288001 12C  Plum, prune, juice-babyfood        2.000000   1.400  1.000

1301055000 13A  Blackberry                        10.000000   1.000  1.000

1301056000 13A  Blackberry, juice                 10.000000   1.000  1.000

1301056001 13A  Blackberry, juice-babyfood        10.000000   1.000  1.000

1301058000 13A  Boysenberry                       10.000000   1.000  1.000

1301208000 13A  Loganberry                        10.000000   1.000  1.000

1301320000 13A  Raspberry                         10.000000   1.000  1.000

1301320001 13A  Raspberry-babyfood                10.000000   1.000  1.000

1301321000 13A  Raspberry, juice                  10.000000   1.000  1.000

1301321001 13A  Raspberry, juice-babyfood         10.000000   1.000  1.000

1302057000 13B  Blueberry                          3.000000   1.000  1.000

1302057001 13B  Blueberry-babyfood                 3.000000   1.000  1.000

1302136000 13B  Currant                            3.000000   1.000  1.000

1302137000 13B  Currant, dried                     3.000000   1.000  1.000

1302149000 13B  Elderberry                         3.000000   1.000  1.000

1302174000 13B  Gooseberry                         3.000000   1.000  1.000

1302191000 13B  Huckleberry                        3.000000   1.000  1.000

1304175000 13D  Grape                              0.810000   1.000  1.000

1304176000 13D  Grape, juice                       0.810000   1.200  1.000

1304176001 13D  Grape, juice-babyfood              0.810000   1.200  1.000

1304179000 13D  Grape, wine and sherry             0.810000   1.000  1.000

1304195000 13D  Kiwifruit, fuzzy                   1.800000   1.000  1.000

1307359000 13G  Strawberry                         5.000000   1.000  1.000

1307359001 13G  Strawberry-babyfood                5.000000   1.000  1.000

1307360000 13G  Strawberry, juice                  5.000000   1.000  1.000

1307360001 13G  Strawberry, juice-babyfood         5.000000   1.000  1.000

1400003000 14   Almond                             0.020000   1.000  1.000

1400003001 14   Almond-babyfood                    0.020000   1.000  1.000

1400004000 14   Almond, oil                        0.020000   1.000  1.000

1400004001 14   Almond, oil-babyfood               0.020000   1.000  1.000

1400282000 14   Pistachio                          0.100000   1.000  1.000

1901028000 19A  Basil, fresh leaves                3.000000   1.000  1.000

1901028001 19A  Basil, fresh leaves-babyfood       3.000000   1.000  1.000

1901029000 19A  Basil, dried leaves               15.000000   1.000  1.000

1901029001 19A  Basil, dried leaves-babyfood      15.000000   1.000  1.000

1901102500 19A  Chive, dried leaves               15.000000   1.000  1.000

1901118000 19A  Cilantro, leaves                   3.000000   1.000  1.000

1901118001 19A  Cilantro, leaves-babyfood          3.000000   1.000  1.000

1901144000 19A  Dillweed                           3.000000   1.000  1.000

1901184000 19A  Herbs, other                       3.000000   1.000  1.000

1901184001 19A  Herbs, other-babyfood              3.000000   1.000  1.000

1901202000 19A  Lemongrass                         3.000000   1.000  1.000

1901220000 19A  Marjoram                           3.000000   1.000  1.000

1901220001 19A  Marjoram-babyfood                  3.000000   1.000  1.000

1901249000 19A  Parsley, dried leaves            170.000000   1.000  1.000

1901249001 19A  Parsley, dried leaves-babyfood   170.000000   1.000  1.000

1901334000 19A  Savory                             3.000000   1.000  1.000

2001319000 20A  Rapeseed, oil                      0.030000   1.000  1.000

2001319001 20A  Rapeseed, oil-babyfood             0.030000   1.000  1.000

3100046000 31   Beef, meat byproducts              0.020000   1.000  1.000

3100046001 31   Beef, meat byproducts-babyfood     0.020000   1.000  1.000

3100048000 31   Beef, kidney                       0.020000   1.000  1.000

3100049000 31   Beef, liver                        0.020000   1.000  1.000

3100049001 31   Beef, liver-babyfood               0.020000   1.000  1.000

3200170000 32   Goat, meat byproducts              0.020000   1.000  1.000

3200172000 32   Goat, kidney                       0.020000   1.000  1.000

3200173000 32   Goat, liver                        0.020000   1.000  1.000

3500340000 35   Sheep, meat byproducts             0.020000   1.000  1.000

3500342000 35   Sheep, kidney                      0.020000   1.000  1.000

3500343000 35   Sheep, liver                       0.020000   1.000  1.000

8601000000 86A  Water, direct, all sources         0.024650   1.000  1.000

8602000000 86B  Water, indirect, all sources       0.024650   1.000  1.000

9500001000 O    Acerola                            1.500000   1.000  1.000

9500016000 O    Artichoke, globe                   4.000000   1.000  1.000

9500020000 O    Avocado                            1.200000   1.000  1.000

9500074000 O    Canistel                           1.200000   1.000  1.000

9500151000 O    Feijoa                             1.500000   1.000  1.000

9500177000 O    Grape, leaves                      0.810000   1.000  1.000

9500178000 O    Grape, raisin                      5.000000   1.000  1.000

9500183000 O    Guava                              1.500000   1.000  1.000

9500183001 O    Guava-babyfood                     1.500000   1.000  1.000

9500209000 O    Longan                             2.000000   1.000  1.000

9500211000 O    Lychee                             2.000000   1.000  1.000

9500212000 O    Lychee, dried                      2.000000   1.850  1.000

9500215000 O    Mango                              1.200000   1.000  1.000

9500215001 O    Mango-babyfood                     1.200000   1.000  1.000

9500216000 O    Mango, dried                       1.200000   1.000  1.000

9500217000 O    Mango, juice                       1.200000   1.000  1.000

9500217001 O    Mango, juice-babyfood              1.200000   1.000  1.000

9500245000 O    Papaya                             1.200000   1.000  1.000

9500245001 O    Papaya-babyfood                    1.200000   1.000  1.000

9500246000 O    Papaya, dried                      1.200000   1.800  1.000

9500247000 O    Papaya, juice                      1.200000   1.500  1.000

9500252000 O    Passionfruit                       1.500000   1.000  1.000

9500252001 O    Passionfruit-babyfood              1.500000   1.000  1.000

9500253000 O    Passionfruit, juice                1.500000   1.000  1.000

9500253001 O    Passionfruit, juice-babyfood       1.500000   1.000  1.000

9500289000 O    Pomegranate                       10.000000   1.000  1.000

9500333000 O    Sapote, Mamey                      1.200000   1.000  1.000

9500351000 O    Spanish lime                       2.000000   1.000  1.000

9500358000 O    Starfruit                          1.500000   1.000  1.000

9500398000 O    Watercress                        20.000000   1.000  1.000

Attachment 3  Results of Acute DEEM-FCID Dietary Exposure Analysis

US EPA                                                      Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for CYPRODINIL                  NHANES 2003-2008 2-Day

Residue file: 288202 Acute Food and Water.R08     Adjustment factor #2 NOT used.

Analysis Date: 04-09-2015/09:51:29    Residue file dated: 04-09-2015/09:44:19

RAC/FF intake summed over 24 hours

Run Comment: ""

======================================================================== =======

Summary calculations--per capita:

                   95th Percentile      99th Percentile     99.9th Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure   % aRfD

                  ---------- --------  ---------- --------  ---------- --------

Total US Population:

                    0.095198     4.76    0.181584     9.08    0.310238    15.51

All Infants:

                    0.101588     5.08    0.168263     8.41    0.529152    26.46

Children 1-2:

                    0.172629     8.63    0.277215    13.86    0.443582    22.18

Children 3-5:

                    0.158663     7.93    0.253670    12.68    0.412075    20.60

Children 6-12:

                    0.083374     4.17    0.178317     8.92    0.276162    13.81

Youth 13-19:

                    0.071553     3.58    0.141338     7.07    0.295995    14.80

Adults 20-49:

                    0.091866     4.59    0.182137     9.11    0.314326    15.72

Adults 50-99:

                    0.091595     4.58    0.154312     7.72    0.272418    13.62

Female 13-49:

                    0.096706     4.84    0.187550     9.38    0.327236    16.36

FOOD ONLY

US EPA                                                      Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for CYPRODINIL                  NHANES 2003-2008 2-Day

Residue file: 288202 Acute Food Only.R08          Adjustment factor #2 NOT used.

Analysis Date: 04-09-2015/09:54:10    Residue file dated: 04-09-2015/09:46:11

RAC/FF intake summed over 24 hours

Run Comment: ""

======================================================================== =======

Summary calculations--per capita:

                   95th Percentile      99th Percentile     99.9th Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure   % aRfD

                  ---------- --------  ---------- --------  ---------- --------

Total US Population:

                    0.094428     4.72    0.179943     9.00    0.309314    15.47

All Infants:

                    0.099629     4.98    0.167443     8.37    0.528808    26.44

Children 1-2:

                    0.172240     8.61    0.275992    13.80    0.445942    22.30

Children 3-5:

                    0.157732     7.89    0.254669    12.73    0.408825    20.44

Children 6-12:

                    0.082435     4.12    0.177091     8.85    0.274520    13.73

Youth 13-19:

                    0.071135     3.56    0.139976     7.00    0.295949    14.80

Adults 20-49:

                    0.091013     4.55    0.180252     9.01    0.312594    15.63

Adults 50-99:

                    0.090599     4.53    0.153660     7.68    0.270453    13.52

Female 13-49:

                    0.095958     4.80    0.187084     9.35    0.325861    16.29

Attachment 4  Results of Chronic DEEM-FCID Dietary Exposure Analysis

US EPA                                                          Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for CYPRODINIL                  NHANES 2003-2008 2-day

Residue file name: C:\Users\tmorton\Documents\My Files\DEEM Files\288202 Cyprodinil\Cyprodinil 4E8273\288202 Chronic Food and Water.R08

                                                     Adjustment factor #2 used.

Analysis Date 04-09-2015/09:48:31     Residue file dated: 04-09-2015/09:43:22

Reference dose (RfD, Chronic) = .027 mg/kg bw/day

======================================================================== =======

                    Total exposure by population subgroup

------------------------------------------------------------------------ -------

                                                    Total Exposure

                                         -----------------------------------

          Population                         mg/kg             Percent of

           Subgroup                       body wt/day             Rfd

--------------------------------------   -------------       ----------------

Total US Population                         0.007794                28.9%

Hispanic                                    0.007303                27.0%

Non-Hisp-White                              0.008032                29.7%

Non-Hisp-Black                              0.006325                23.4%

Non-Hisp-Other                              0.009383                34.8%

Nursing Infants                             0.008687                32.2%

Non-Nursing Infants                         0.014986                55.5%

Female 13+ PREG                             0.006602                24.5%

Children 1-6                                0.018324                67.9%

Children 7-12                               0.007696                28.5%

Male 13-19                                  0.004191                15.5%

Female 13-19/NP                             0.005153                19.1%

Male 20+                                    0.006066                22.5%

Female 20+/NP                               0.007731                28.6%

Seniors 55+                                 0.007840                29.0%

All Infants                                 0.013042                48.3%

Female 13-50                                0.006754                25.0%

Children 1-2                                0.023045                85.4%

Children 3-5                                0.016592                61.5%

Children 6-12                               0.008522                31.6%

Youth 13-19                                 0.004665                17.3%

Adults 20-49                                0.006327                23.4%

Adults 50-99                                0.007772                28.8%

Female 13-49                                0.006706                24.8%

------------------------------------------------------------------------ -------

FOOD ONLY

US EPA                                                          Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for CYPRODINIL                  NHANES 2003-2008 2-day

Residue file name: C:\Users\tmorton\Documents\My Files\DEEM Files\288202 Cyprodinil\Cyprodinil 4E8273\288202 Chronic Food Only.R08

                                                     Adjustment factor #2 used.

Analysis Date 04-09-2015/09:49:01     Residue file dated: 04-09-2015/09:47:27

Reference dose (RfD, Chronic) = .027 mg/kg bw/day

======================================================================== =======

                    Total exposure by population subgroup

------------------------------------------------------------------------ -------

                                                    Total Exposure

                                         -----------------------------------

          Population                         mg/kg             Percent of

           Subgroup                       body wt/day             Rfd

--------------------------------------   -------------       ----------------

Total US Population                         0.007277                27.0%

Hispanic                                    0.006810                25.2%

Non-Hisp-White                              0.007501                27.8%

Non-Hisp-Black                              0.005899                21.8%

Non-Hisp-Other                              0.008788                32.5%

Nursing Infants                             0.008220                30.4%

Non-Nursing Infants                         0.013270                49.1%

Female 13+ PREG                             0.006116                22.7%

Children 1-6                                0.017663                65.4%

Children 7-12                               0.007266                26.9%

Male 13-19                                  0.003836                14.2%

Female 13-19/NP                             0.004755                17.6%

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Female 13-50                                0.006241                23.1%

Children 1-2                                0.022300                82.6%

Children 3-5                                0.015965                59.1%

Children 6-12                               0.008070                29.9%

Youth 13-19                                 0.004289                15.9%

Adults 20-49                                0.005812                21.5%

Adults 50-99                                0.007263                26.9%

Female 13-49                                0.006193                22.9%

------------------------------------------------------------------------ -------

Cyprodinil (PC Code 288202)	Dietary Exposure and Risk Assessment                  DP # 425997:

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