  SEQ CHAPTER \h \r 1

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF PREVENTION, PESTICIDES,

                                                                                AND TOXIC SUBSTANCES

MEMORANDUM

Date:  		02-JUN-2009

SUBJECT:	Saflufenacil.  Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Section 3 Registration Action in/on Legume Vegetables (Crop Group 06), the Foliage of Legume Vegetables (Crop Group 07), Citrus Fruits (Crop Group 10), Pome Fruits (Crop Group 11), Stone Fruits (Crop Group 12), Tree Nuts (Crop Group14), Cereal Grains (Crop Group 15), Forage, Fodder and Straw of Cereal Grains (Crop Group 16), Grapes, Cotton, Sunflower, and Livestock Commodities.

PC Code:  118203	DP Barcode:  D364183

Decision No.:  389161	Registration Nos.:  7969-ETA, 7969-ETI, 7969-ETO, 7969-EIN

Petition No.:  8F7322	Regulatory Action:  Sec. 3 Registration

Risk Assessment Type:  Dietary	Case No.:  NA

TXR No.:  NA	CAS No.:  372137-35-4

MRID Nos.: NA	40 CFR:  §180.xxx

FROM:	George F. Kramer, Ph.D., Senior Chemist

Risk Assessment Branch 1 (RAB1)/Health Effects Division (HED; 7509P)

THROUGH:	Mohsen Sahafeyen, Chemist, RAB6/HED

P. Yvonne Barnes, Biologist, Reregistration Branch 2 (RAB6)/HED

Dietary Exposure Science Advisory Council (DESAC)

HED (7509P)

and

Dana M. Vogel, Branch Chief

RAB1/HED (7509P)

TO:		Lisa Austin, Ph.D., Toxicologist

		RAB1/HED (7509P)

and

Kathryn Montague/Joanne Miller, PM Team 23

Registration Division (RD) (7505P)

Executive Summary

Acute and chronic dietary-exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID™, Version 2.03) which use food consumption data from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998.  These analyses was performed to support a Section 3 request for the use of saflufenacil in/on legume vegetables (group 06), citrus fruits (group 10), pome fruits (group 11), stone fruits (group 12), tree nuts (group14), cereal grains (group 15), grapes, and sunflower.

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

The unrefined acute analysis assumed 100% crop treated (CT), DEEM™ 7.81 default concentration factors, and tolerance-level residues for all commodities.  Drinking water was incorporated directly into the dietary assessment using the concentration for ground water generated by the Tier II Pesticide Root Zone Model Ground Water (PRZM GW).  The acute dietary exposure and risk estimates (food + water) are 0.010051 mg/kg/day for the general U.S. population (<1% of the acute population-adjusted dose (aPAD)) and 0.036991 mg/kg/day (<1% of the aPAD) for the most highly exposed population subgroup (all infants (<1 year old)) and are thus below HED’s level of concern (<100% aPAD).

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

The unrefined chronic analysis assumed 100% CT, DEEM™ 7.81 default concentration factors, and tolerance-level residues for all commodities.  Drinking water was incorporated directly into the dietary assessment using the concentration for ground water generated by PRZM GW.  The chronic dietary exposure and risk estimates (food + water) are 0.004043 mg/kg/day for the general U.S. population (8.8% of the chronic population-adjusted dose (cPAD)) and 0.012951 mg/kg/day (28% of the cPAD) for the most highly exposed population subgroup (all infants (<1 year old)) and are thus below HED’s level of concern (<100% cPAD).

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

Saflufenacil is classified as “not likely carcinogenic to humans.”  Therefore, cancer risk is not a concern for this chemical.

I.  Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population-adjusted dose (PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, i.e.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  HED is generally concerned when estimated cancer risk exceeds one in one million.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link:      HYPERLINK "http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf"  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see SOP 99.6 (20-AUG-1999).

Saflufenacil is a new active ingredient.  Therefore, this document presents the first dietary risk assessment for saflufenacil conducted by HED.

II.  Residue Information

Saflufenacil Proposed and Registered Uses:

Residues of Concern:  The nature of the residue in plants (resulting from preplant/preemergence application), rotational crops, and livestock is adequately understood based on acceptable metabolism studies conducted on corn, soybean, tomato, rotational crops, lactating goats, and laying hens.  The residues of concern for the tolerance expression and risk assessment are shown in Table 1 (Memo, B. Daiss, 01/06/09; D359645).

Table 1.  Summary of Metabolites and Degradates to be included in the Risk Assessment.

Matrix	Residues included in Risk Assessment	Residues included in Tolerance Expression

Plants	Primary Crops	Saflufenacil + M800H11, M800H35	Saflufenacil + M800H11, M800H35

	Rotational Crops

Livestock	Ruminants	Saflufenacil	Saflufenacil

	Poultry

Drinking Water	Saflufenacil + M800H01, M800H02, M800H07, M800H08, M800H15, M800H22, Product 8	Not Applicable

Established Tolerances:  There are currently no established U.S. tolerances for residues of saflufenacil.

Recommended Tolerances:  Based on the residue chemistry data submitted with the current petition, HED recommended for establishment of the following crop tolerances for combined residues saflufenacil plus metabolites M800H11 and M800H35, calculated as saflufenacil equivalents and livestock tolerances, expressed as parent only (G. Kramer, 06/04/09; DP# 349938):

Table 2.  Tolerance Summary for Saflufenacil.

Commodity	Recommended Tolerance (ppm)

Vegetable, legume, group 6	0.03

Vegetable, foliage of legume, group 7	0.10

Fruit, citrus, group 10	0.03

Fruit, pome, group 11	0.03

Fruit, stone, group 12	0.03

Nut, tree, group 14	0.03

Almond, hulls	0.10

Grain, cereal, group 15	0.03

Grain, cereal, forage, fodder and straw group 16	0.10

Cotton, undelinted seed	0.03

Cotton, gin byproducts	0.10

Sunflower, seed	1.0

Grape	0.03

Milk	0.01

Cattle, meat	0.01

Cattle, fat	0.01

Cattle, liver	0.80

Cattle, meat byproducts, except liver	0.02

Goat, meat	0.01

Goat, fat	0.01

Goat, liver	0.80

Goat, meat byproducts, except liver	0.02

Hog, meat	0.01

Hog, fat	0.01

Hog, liver	0.80

Hog, meat byproducts, except liver	0.02

Sheep, meat	0.01

Sheep, fat	0.01

Sheep, liver	0.80

Sheep, meat byproducts, except liver	0.02

Horse, meat	0.01

Horse, fat	0.01

Horse, liver	0.80

Horse, meat byproducts, except liver	0.02

Residue Data used for Acute and Chronic Assessments:

The acute and chronic analyses assumed 100% CT, DEEM™ 7.81 default concentration factors, and tolerance-level residues for all commodities.

  Drinking Water Data

™ into the food categories “water, direct, all sources” and “water, indirect, all sources.”

Screening EDWCs (Table 3) of saflufenacil were generated with FQPA Index Reservoir Screening Tool (FIRST) for surface water and with PRZM GW for ground water.  Modeled application rates represent the maximum use patterns of five proposed end-use labels with selected uses on row crops, orchard trees, vineyards, tree plantations, and non-agricultural areas.  Remaining model input parameters were chosen according to current guidance (USEPA, 2002).  EDWCs reflect exposure to saflufenacil and all degradates of concern in drinking water (Table 1).

Table 3.  Tiered EDWCs for Proposed Saflufenacil Uses.

Source (Tier: Model)	1-in-10-year Peak Exposure (ppb)	1-in-10-year Annual Mean Exposure (ppb)

Surface water (Tier I: FIRST)	37.3	23.8

Ground water (Tier II: PRZM GW)	180

(used in acute analysis)	173

(used in chronic analysis)

IV.  DEEM-FCID™ Program and Consumption Information

Saflufenacil acute and chronic dietary exposure assessments were conducted using DEEM-FCID™, Version 2.03, which incorporates consumption data from USDA’s CSFII, 1994-1996 and 1998.  The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods “as consumed” (i.e., apple pie) are linked to EPA-defined food commodities (i.e. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2 years old, children 3-5 years old, children 6-12 years old, youth 13-19 years old, females 13-49 years old, adults 20-49 years old, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (i.e., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, for Tiers 1 and 2, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

V.  Toxicological Information

Table 4.  Summary of Toxicological Doses and Endpoints for saflufenacil for Use in Dietary Human Health Risk Assessments.

Exposure/

Scenario	Point of Departure	Uncertainty/

FQPA SFs	RfD, PAD, LOC for Risk Assessment	Study and Toxicological Effects

Acute Dietary (General Population, including Infants and Children)	NOAEL = 500 mg/kg/day

	UFA = 10X

UFH = 10X

FQPA SF = 1X	Acute RfD =

5.0 mg/kg

aPAD = 5.0 mg/kg	Acute Neurotoxicity Study

NOAEL = 500 (M) and 2000 (F) mg/kg/day.

LOAEL was 2000 mg/kg/day (males) based on the decreased motor activity representing mild and transient systemic toxicity.

LOAEL was not established for females.

Chronic Dietary (All Populations)	NOAEL = 4.6 mg/kg/day

 	UFA = 10X

UFH = 10X

FQPA SF = 1X

	Chronic RfD = 0.046 mg/kg/day

cPAD = 0.046 mg/kg/day	Chronic/Carcinogenicity (mouse)

NOAEL = 4.6 mg/kg bw/d (males) and 18.9 mg/kg bw/d (females).

LOAELs = 13.8 mg/kg bw/d (males) and 38.1 mg/kg bw/day (females) based on decreased red blood cells, hemoglobin, and hematocrit and porphyria observed in the satellite group.

Cancer (oral, dermal, inhalation)	Classification:  Not carcinogenic based on the lack of tumors in the mouse and rat carcinogenicity studies and lack of mutagenicity.

NOAEL = no-observed adverse-effect level.  LOAEL = lowest-observed adverse-effect level.  UF = uncertainty factor.  UFA = extrapolation from animal to human (interspecies).  UFH = potential variation in sensitivity among members of the human population (intraspecies).  FQPA SF = FQPA Safety Factor.  PAD = population-adjusted dose (a = acute, c = chronic).  RfD = reference dose.  LOC = level of concern.

VI.  Results/Discussion

™ analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in Table 3 are for the general U.S. population, all infants (<1 year old), children 1-2 years old, children 3-5 years old, children 6-12 years old, youth 13-19 years old, females 13-49 years old, adults 20-49 years old, and adults 50+ years old.

Results of Acute and Chronic Dietary Exposure Analyses

The acute dietary exposure for food and drinking water utilized (<1% of the aPAD for the U.S. population.  The acute dietary exposure for the highest exposed population subgroup, all infants (<1 year old), is <1% of the aPAD.

The chronic dietary exposure for food and drinking water utilized 8.8% of the cPAD for the U.S. population.  The chronic dietary exposure for the highest exposed population subgroup, all infants (<1 year old), is 28% of the cPAD.

The results of the acute and chronic dietary exposure analyses are reported in Table 5.

Table 5.  Summary of Dietary (Food and Drinking Water) Exposure Risk for Saflufenacil.

Population Subgroup	Acute Dietary

(95th Percentile)	Chronic Dietary

	Dietary Exposure (mg/kg/day)	% aPAD	Dietary Exposure

(mg/kg/day)	% cPAD

General U.S. Population	0.010051	<1	0.004043	8.8

All Infants (<1 year old)	0.036991	<1	0.012951	28

Children 1-2 years old	0.016375	<1	0.006895	15

Children 3-5 years old	0.014835	<1	0.006176	13

Children 6-12 years old	0.010181	<1	0.004141	9.0

Youth 13-19 years old	0.008192	<1	0.003002	6.5

Adults 20-49 years old	0.009009	<1	0.003672	8.0

Adults 50+ years old	0.008151	<1	0.003821	8.3

Females 13-49 years old	0.009122	<1	0.003659	8.0

*The values for the highest exposed population for each type of risk assessment are bolded.

VII.  Characterization of Inputs/Outputs

These acute and chronic dietary exposure and risk estimates are conservative since they assumed 100% CT, DEEM™ 7.81 default concentration factors, and tolerance-level residues and were based on screening level estimates of drinking water concentrations generated by PRZM GW.  They could be further refined through the use of anticipated residues, empirical processing factors and % CT data, as well as refined drinking water estimates.

VIII.  Conclusions

™ indicates that dietary risks to saflufenacil from food and drinking water is well below HED’s levels of concern for this pesticide.  Estimated acute dietary risks are <1% of the aPAD for the general U.S. population and all population subgroups and estimated chronic dietary risks are ≤28% of the cPAD for the general U.S. population and all population subgroups.

IX.  List of Attachments

Acute Food plus Water Residue Input File.

Acute Results File.

Chronic Food plus Water Residue Input File.

Chronic Results File.

cc:  G. Kramer (RAB1)

RDI:  M. Sahafeyen (5/12/09), Y. Barnes (6/2/09)

G.F. Kramer:S10781:PY-S:(703)305-5079:7509P:RAB1

Acute Food plus Water Residue Input File

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for SAFLUFENACIL                       1994-98 data

Residue file: C:\Documents and Settings\gkramer\My Documents\GK\%Saflufenacil\Saflufenacil_Acute.R98

                                                           Adjust. #2 NOT used

Analysis Date 04-17-2009             Residue file dated: 04-16-2009/13:35:15/8

Reference dose (RfD) = 0.046 mg/kg bw/day

------------------------------------------------------------------------ --------

Food Crop                                       Residue       Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)

                                                             #1         #2

-------- ---- -------------------------------   ---------- ------     ------   -------

14000030 14   Almond                             0.030000   1.000      1.000

14000031 14   Almond-babyfood                    0.030000   1.000      1.000

14000040 14   Almond, oil                        0.030000   1.000      1.000

14000041 14   Almond, oil-babyfood               0.030000   1.000      1.000

11000070 11   Apple, fruit with peel             0.030000   1.000      1.000

11000080 11   Apple, peeled fruit                0.030000   1.000      1.000

11000081 11   Apple, peeled fruit-babyfood       0.030000   1.000      1.000

11000090 11   Apple, dried                       0.030000   1.000      8.000

11000091 11   Apple, dried-babyfood              0.030000   1.000      8.000

11000100 11   Apple, juice                       0.030000   1.000      1.300

11000101 11   Apple, juice-babyfood              0.030000   1.000      1.300

11000110 11   Apple, sauce                       0.030000   1.000      1.000

11000111 11   Apple, sauce-babyfood              0.030000   1.000      1.000

12000120 12   Apricot                            0.030000   1.000      1.000

12000121 12   Apricot-babyfood                   0.030000   1.000      1.000

12000130 12   Apricot, dried                     0.030000   1.000      6.000

12000140 12   Apricot, juice                     0.030000   1.000      1.000

12000141 12   Apricot, juice-babyfood            0.030000   1.000      1.000

15000250 15   Barley, pearled barley             0.030000   1.000      1.000

15000251 15   Barley, pearled barley-babyfood    0.030000   1.000      1.000

15000260 15   Barley, flour                      0.030000   1.000      1.000

15000261 15   Barley, flour-babyfood             0.030000   1.000      1.000

15000270 15   Barley, bran                       0.030000   1.000      1.000

06030300 6C   Bean, black, seed                  0.030000   1.000      1.000

06020310 6B   Bean, broad, succulent             0.030000   1.000      1.000

06030320 6C   Bean, broad, seed                  0.030000   1.000      1.000

06020330 6B   Bean, cowpea, succulent            0.030000   1.000      1.000

06030340 6C   Bean, cowpea, seed                 0.030000   1.000      1.000

06030350 6C   Bean,  great northern, seed        0.030000   1.000      1.000

06030360 6C   Bean, kidney, seed                 0.030000   1.000      1.000

06020370 6B   Bean, lima, succulent              0.030000   1.000      1.000

06030380 6C   Bean, lima, seed                   0.030000   1.000      1.000

06030390 6C   Bean, mung, seed                   0.030000   1.000      1.000

06030400 6C   Bean, navy, seed                   0.030000   1.000      1.000

06030410 6C   Bean, pink, seed                   0.030000   1.000      1.000

06030420 6C   Bean, pinto, seed                  0.030000   1.000      1.000

06010430 6A   Bean, snap, succulent              0.030000   1.000      1.000

06010431 6A   Bean, snap, succulent-babyfood     0.030000   1.000      1.000

21000440 M    Beef, meat                         0.010000   1.000      1.000

21000441 M    Beef, meat-babyfood                0.010000   1.000      1.000

21000450 M    Beef, meat, dried                  0.010000   1.000      1.920

21000460 M    Beef, meat byproducts              0.020000   1.000      1.000

21000461 M    Beef, meat byproducts-babyfood     0.020000   1.000      1.000

21000470 M    Beef, fat                          0.010000   1.000      1.000

21000471 M    Beef,fat-babyfood                  0.010000   1.000      1.000

21000480 M    Beef, kidney                       0.010000   1.000      1.000

21000490 M    Beef, liver                        0.800000   1.000      1.000

21000491 M    Beef, liver-babyfood               0.800000   1.000      1.000

14000590 14   Brazil nut                         0.030000   1.000      1.000

15000650 15   Buckwheat                          0.030000   1.000      1.000

15000660 15   Buckwheat, flour                   0.030000   1.000      1.000

14000680 14   Butternut                          0.030000   1.000      1.000

14000810 14   Cashew                             0.030000   1.000      1.000

12000900 12   Cherry                             0.030000   1.000      1.000

12000901 12   Cherry-babyfood                    0.030000   1.000      1.000

12000910 12   Cherry, juice                      0.030000   1.000      1.500

12000911 12   Cherry, juice-babyfood             0.030000   1.000      1.500

14000920 14   Chestnut                           0.030000   1.000      1.000

06030980 6C   Chickpea, seed                     0.030000   1.000      1.000

06030981 6C   Chickpea, seed-babyfood            0.030000   1.000      1.000

06030990 6C   Chickpea, flour                    0.030000   1.000      1.000

10001060 10   Citrus citron                      0.030000   1.000      1.000

10001070 10   Citrus hybrids                     0.030000   1.000      1.000

10001080 10   Citrus, oil                        0.030000   1.000      1.000

15001200 15   Corn, field, flour                 0.030000   1.000      1.000

15001201 15   Corn, field, flour-babyfood        0.030000   1.000      1.000

15001210 15   Corn, field, meal                  0.030000   1.000      1.000

15001211 15   Corn, field, meal-babyfood         0.030000   1.000      1.000

15001220 15   Corn, field, bran                  0.030000   1.000      1.000

15001230 15   Corn, field, starch                0.030000   1.000      1.000

15001231 15   Corn, field, starch-babyfood       0.030000   1.000      1.000

15001240 15   Corn, field, syrup                 0.030000   1.000      1.500

15001241 15   Corn, field, syrup-babyfood        0.030000   1.000      1.500

15001250 15   Corn, field, oil                   0.030000   1.000      1.000

15001251 15   Corn, field, oil-babyfood          0.030000   1.000      1.000

15001260 15   Corn, pop                          0.030000   1.000      1.000

15001270 15   Corn, sweet                        0.030000   1.000      1.000

15001271 15   Corn, sweet-babyfood               0.030000   1.000      1.000

95001280 O    Cottonseed, oil                    0.030000   1.000      1.000

95001281 O    Cottonseed, oil-babyfood           0.030000   1.000      1.000

11001290 11   Crabapple                          0.030000   1.000      1.000

14001550 14   Filbert                            0.030000   1.000      1.000

14001560 14   Filbert, oil                       0.030000   1.000      1.000

23001690 M    Goat, meat                         0.010000   1.000      1.000

23001700 M    Goat, meat byproducts              0.020000   1.000      1.000

23001710 M    Goat, fat                          0.010000   1.000      1.000

23001720 M    Goat, kidney                       0.010000   1.000      1.000

23001730 M    Goat, liver                        0.800000   1.000      1.000

95001750 O    Grape                              0.030000   1.000      1.000

95001760 O    Grape, juice                       0.030000   1.000      1.200

95001761 O    Grape, juice-babyfood              0.030000   1.000      1.200

95001770 O    Grape, leaves                      0.030000   1.000      1.000

95001780 O    Grape, raisin                      0.030000   1.000      4.300

95001790 O    Grape, wine and sherry             0.030000   1.000      1.000

10001800 10   Grapefruit                         0.030000   1.000      1.000

10001810 10   Grapefruit, juice                  0.030000   1.000      2.100

06031820 6C   Guar, seed                         0.030000   1.000      1.000

06031821 6C   Guar, seed-babyfood                0.030000   1.000      1.000

14001850 14   Hickory nut                        0.030000   1.000      1.000

24001890 M    Horse, meat                        0.010000   1.000      1.000

10001970 10   Kumquat                            0.030000   1.000      1.000

10001990 10   Lemon                              0.030000   1.000      1.000

10002000 10   Lemon, juice                       0.030000   1.000      2.000

10002001 10   Lemon, juice-babyfood              0.030000   1.000      2.000

10002010 10   Lemon, peel                        0.030000   1.000      1.000

06032030 6C   Lentil, seed                       0.030000   1.000      1.000

10002060 10   Lime                               0.030000   1.000      1.000

10002070 10   Lime, juice                        0.030000   1.000      2.000

10002071 10   Lime, juice-babyfood               0.030000   1.000      2.000

11002100 11   Loquat                             0.030000   1.000      1.000

14002130 14   Macadamia nut                      0.030000   1.000      1.000

27002220 D    Milk, fat                          0.010000   1.000      1.000

27002221 D    Milk, fat - baby food/infant for   0.010000   1.000      1.000

27012230 D    Milk, nonfat solids                0.010000   1.000      1.000

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000      1.000

27022240 D    Milk, water                        0.010000   1.000      1.000

27022241 D    Milk, water-babyfood/infant form   0.010000   1.000      1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000      1.000

15002260 15   Millet, grain                      0.030000   1.000      1.000

12002300 12   Nectarine                          0.030000   1.000      1.000

15002310 15   Oat, bran                          0.030000   1.000      1.000

15002320 15   Oat, flour                         0.030000   1.000      1.000

15002321 15   Oat, flour-babyfood                0.030000   1.000      1.000

15002330 15   Oat, groats/rolled oats            0.030000   1.000      1.000

15002331 15   Oat, groats/rolled oats-babyfood   0.030000   1.000      1.000

10002400 10   Orange                             0.030000   1.000      1.000

10002410 10   Orange, juice                      0.030000   1.000      1.800

10002411 10   Orange, juice-babyfood             0.030000   1.000      1.800

10002420 10   Orange, peel                       0.030000   1.000      1.000

06022550 6B   Pea, succulent                     0.030000   1.000      1.000

06022551 6B   Pea, succulent-babyfood            0.030000   1.000      1.000

06032560 6C   Pea, dry                           0.030000   1.000      1.000

06032561 6C   Pea, dry-babyfood                  0.030000   1.000      1.000

06012570 6A   Pea, edible podded, succulent      0.030000   1.000      1.000

06032580 6C   Pea, pigeon, seed                  0.030000   1.000      1.000

06022590 6B   Pea, pigeon, succulent             0.030000   1.000      1.000

12002600 12   Peach                              0.030000   1.000      1.000

12002601 12   Peach-babyfood                     0.030000   1.000      1.000

12002610 12   Peach, dried                       0.030000   1.000      7.000

12002611 12   Peach, dried-babyfood              0.030000   1.000      7.000

12002620 12   Peach, juice                       0.030000   1.000      1.500

12002621 12   Peach, juice-babyfood              0.030000   1.000      1.500

11002660 11   Pear                               0.030000   1.000      1.000

11002661 11   Pear-babyfood                      0.030000   1.000      1.000

11002670 11   Pear, dried                        0.030000   1.000      6.250

11002680 11   Pear, juice                        0.030000   1.000      1.000

11002681 11   Pear, juice-babyfood               0.030000   1.000      1.000

14002690 14   Pecan                              0.030000   1.000      1.000

14002820 14   Pistachio                          0.030000   1.000      1.000

12002850 12   Plum                               0.030000   1.000      1.000

12002851 12   Plum-babyfood                      0.030000   1.000      1.000

12002860 12   Plum, prune, fresh                 0.030000   1.000      1.000

12002861 12   Plum, prune, fresh-babyfood        0.030000   1.000      1.000

12002870 12   Plum, prune, dried                 0.030000   1.000      5.000

12002871 12   Plum, prune, dried-babyfood        0.030000   1.000      5.000

12002880 12   Plum, prune, juice                 0.030000   1.000      1.400

12002881 12   Plum, prune, juice-babyfood        0.030000   1.000      1.400

25002900 M    Pork, meat                         0.010000   1.000      1.000

25002901 M    Pork, meat-babyfood                0.010000   1.000      1.000

25002910 M    Pork, skin                         0.010000   1.000      1.000

25002920 M    Pork, meat byproducts              0.020000   1.000      1.000

25002921 M    Pork, meat byproducts-babyfood     0.020000   1.000      1.000

25002930 M    Pork, fat                          0.010000   1.000      1.000

25002931 M    Pork, fat-babyfood                 0.010000   1.000      1.000

25002940 M    Pork, kidney                       0.010000   1.000      1.000

25002950 M    Pork, liver                        0.800000   1.000      1.000

10003070 10   Pummelo                            0.030000   1.000      1.000

11003100 11   Quince                             0.030000   1.000      1.000

29003120 M    Rabbit, meat                       0.010000   1.000      1.000

15003230 15   Rice, white                        0.030000   1.000      1.000

15003231 15   Rice, white-babyfood               0.030000   1.000      1.000

15003240 15   Rice, brown                        0.030000   1.000      1.000

15003241 15   Rice, brown-babyfood               0.030000   1.000      1.000

15003250 15   Rice, flour                        0.030000   1.000      1.000

15003251 15   Rice, flour-babyfood               0.030000   1.000      1.000

15003260 15   Rice, bran                         0.030000   1.000      1.000

15003261 15   Rice, bran-babyfood                0.030000   1.000      1.000

15003280 15   Rye, grain                         0.030000   1.000      1.000

15003290 15   Rye, flour                         0.030000   1.000      1.000

26003390 M    Sheep, meat                        0.010000   1.000      1.000

26003391 M    Sheep, meat-babyfood               0.010000   1.000      1.000

26003400 M    Sheep, meat byproducts             0.010000   1.000      1.000

26003410 M    Sheep, fat                         0.010000   1.000      1.000

26003411 M    Sheep, fat-babyfood                0.010000   1.000      1.000

26003420 M    Sheep, kidney                      0.010000   1.000      1.000

26003430 M    Sheep, liver                       0.010000   1.000      1.000

15003440 15   Sorghum, grain                     0.030000   1.000      1.000

15003450 15   Sorghum, syrup                     0.030000   1.000      1.000

06003470 6    Soybean, seed                      0.030000   1.000      1.000

06003480 6    Soybean, flour                     0.030000   1.000      1.000

06003481 6    Soybean, flour-babyfood            0.030000   1.000      1.000

06003490 6    Soybean, soy milk                  0.030000   1.000      1.000

06003491 6    Soybean, soy milk-babyfood or in   0.030000   1.000      1.000

06003500 6    Soybean, oil                       0.030000   1.000      1.000

06003501 6    Soybean, oil-babyfood              0.030000   1.000      1.000

20003640 20   Sunflower, seed                    1.000000   1.000      1.000

20003650 20   Sunflower, oil                     1.000000   1.000      1.000

20003651 20   Sunflower, oil-babyfood            1.000000   1.000      1.000

10003690 10   Tangerine                          0.030000   1.000      1.000

10003700 10   Tangerine, juice                   0.030000   1.000      1.000

15003810 15   Triticale, flour                   0.030000   1.000      1.000

15003811 15   Triticale, flour-babyfood          0.030000   1.000      1.000

14003910 14   Walnut                             0.030000   1.000      1.000

86010000 O    Water, direct, all sources         0.180000   1.000      1.000

86020000 O    Water, indirect, all sources       0.180000   1.000      1.000

15004010 15   Wheat, grain                       0.030000   1.000      1.000

15004011 15   Wheat, grain-babyfood              0.030000   1.000      1.000

15004020 15   Wheat, flour                       0.030000   1.000      1.000

15004021 15   Wheat, flour-babyfood              0.030000   1.000      1.000

15004030 15   Wheat, germ                        0.030000   1.000      1.000

15004040 15   Wheat, bran                        0.030000   1.000      1.000

15004050 15   Wild rice                          0.030000   1.000      1.000

Acute Results File.

U.S. Environmental Protection Agency                                  Ver. 2.02

DEEM-FCID ACUTE Analysis for SAFLUFENACIL                        (1994-98 data)

Residue file: Saflufenacil_Acute.R98                  Adjustment factor #2 used.

Analysis Date: 04-16-2009/13:36:21    Residue file dated: 04-16-2009/13:35:15/8

Daily totals for food and foodform consumption used.

Run Comment: ""

======================================================================== =======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure   % aRfD

                  ---------- --------  ---------- --------  ---------- --------

U.S. Population:

                    0.010051     0.20    0.018395     0.37    0.036701     0.73

All infants:

                    0.036991     0.74    0.051982     1.04    0.092997     1.86

Children 1-2 yrs:

                    0.016375     0.33    0.027222     0.54    0.040096     0.80

Children 3-5 yrs:

                    0.014835     0.30    0.022292     0.45    0.035673     0.71

Children 6-12 yrs:

                    0.010181     0.20    0.016696     0.33    0.023179     0.46

Youth 13-19 yrs:

                    0.008192     0.16    0.013104     0.26    0.023368     0.47

Adults 20-49 yrs:

                    0.009009     0.18    0.014796     0.30    0.026744     0.53

Adults 50+ yrs:

                    0.008151     0.16    0.011642     0.23    0.019521     0.39

Females 13-49 yrs:

                    0.009122     0.18    0.014496     0.29    0.025509     0.51

Chronic Food plus Water Residue Input File.

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for SAFLUFENACIL                       1994-98 data

Residue file: C:\Documents and Settings\gkramer\My Documents\GK\%Saflufenacil\Saflufenacil_Chronic.R98

                                                           Adjust. #2 NOT used

Analysis Date 04-17-2009             Residue file dated: 04-16-2009/13:34:26/8

Reference dose (RfD) = 0.046 mg/kg bw/day

------------------------------------------------------------------------ --------

Food Crop                                       Residue       Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)

                                                             #1         #2

-------- ---- -------------------------------   ---------- ------     ------   -------

14000030 14   Almond                             0.030000   1.000      1.000

14000031 14   Almond-babyfood                    0.030000   1.000      1.000

14000040 14   Almond, oil                        0.030000   1.000      1.000

14000041 14   Almond, oil-babyfood               0.030000   1.000      1.000

11000070 11   Apple, fruit with peel             0.030000   1.000      1.000

11000080 11   Apple, peeled fruit                0.030000   1.000      1.000

11000081 11   Apple, peeled fruit-babyfood       0.030000   1.000      1.000

11000090 11   Apple, dried                       0.030000   1.000      8.000

11000091 11   Apple, dried-babyfood              0.030000   1.000      8.000

11000100 11   Apple, juice                       0.030000   1.000      1.300

11000101 11   Apple, juice-babyfood              0.030000   1.000      1.300

11000110 11   Apple, sauce                       0.030000   1.000      1.000

11000111 11   Apple, sauce-babyfood              0.030000   1.000      1.000

12000120 12   Apricot                            0.030000   1.000      1.000

12000121 12   Apricot-babyfood                   0.030000   1.000      1.000

12000130 12   Apricot, dried                     0.030000   1.000      6.000

12000140 12   Apricot, juice                     0.030000   1.000      1.000

12000141 12   Apricot, juice-babyfood            0.030000   1.000      1.000

15000250 15   Barley, pearled barley             0.030000   1.000      1.000

15000251 15   Barley, pearled barley-babyfood    0.030000   1.000      1.000

15000260 15   Barley, flour                      0.030000   1.000      1.000

15000261 15   Barley, flour-babyfood             0.030000   1.000      1.000

15000270 15   Barley, bran                       0.030000   1.000      1.000

06030300 6C   Bean, black, seed                  0.030000   1.000      1.000

06020310 6B   Bean, broad, succulent             0.030000   1.000      1.000

06030320 6C   Bean, broad, seed                  0.030000   1.000      1.000

06020330 6B   Bean, cowpea, succulent            0.030000   1.000      1.000

06030340 6C   Bean, cowpea, seed                 0.030000   1.000      1.000

06030350 6C   Bean,  great northern, seed        0.030000   1.000      1.000

06030360 6C   Bean, kidney, seed                 0.030000   1.000      1.000

06020370 6B   Bean, lima, succulent              0.030000   1.000      1.000

06030380 6C   Bean, lima, seed                   0.030000   1.000      1.000

06030390 6C   Bean, mung, seed                   0.030000   1.000      1.000

06030400 6C   Bean, navy, seed                   0.030000   1.000      1.000

06030410 6C   Bean, pink, seed                   0.030000   1.000      1.000

06030420 6C   Bean, pinto, seed                  0.030000   1.000      1.000

06010430 6A   Bean, snap, succulent              0.030000   1.000      1.000

06010431 6A   Bean, snap, succulent-babyfood     0.030000   1.000      1.000

21000440 M    Beef, meat                         0.010000   1.000      1.000

21000441 M    Beef, meat-babyfood                0.010000   1.000      1.000

21000450 M    Beef, meat, dried                  0.010000   1.000      1.920

21000460 M    Beef, meat byproducts              0.020000   1.000      1.000

21000461 M    Beef, meat byproducts-babyfood     0.020000   1.000      1.000

21000470 M    Beef, fat                          0.010000   1.000      1.000

21000471 M    Beef,fat-babyfood                  0.010000   1.000      1.000

21000480 M    Beef, kidney                       0.010000   1.000      1.000

21000490 M    Beef, liver                        0.800000   1.000      1.000

21000491 M    Beef, liver-babyfood               0.800000   1.000      1.000

14000590 14   Brazil nut                         0.030000   1.000      1.000

15000650 15   Buckwheat                          0.030000   1.000      1.000

15000660 15   Buckwheat, flour                   0.030000   1.000      1.000

14000680 14   Butternut                          0.030000   1.000      1.000

14000810 14   Cashew                             0.030000   1.000      1.000

12000900 12   Cherry                             0.030000   1.000      1.000

12000901 12   Cherry-babyfood                    0.030000   1.000      1.000

12000910 12   Cherry, juice                      0.030000   1.000      1.500

12000911 12   Cherry, juice-babyfood             0.030000   1.000      1.500

14000920 14   Chestnut                           0.030000   1.000      1.000

06030980 6C   Chickpea, seed                     0.030000   1.000      1.000

06030981 6C   Chickpea, seed-babyfood            0.030000   1.000      1.000

06030990 6C   Chickpea, flour                    0.030000   1.000      1.000

10001060 10   Citrus citron                      0.030000   1.000      1.000

10001070 10   Citrus hybrids                     0.030000   1.000      1.000

10001080 10   Citrus, oil                        0.030000   1.000      1.000

15001200 15   Corn, field, flour                 0.030000   1.000      1.000

15001201 15   Corn, field, flour-babyfood        0.030000   1.000      1.000

15001210 15   Corn, field, meal                  0.030000   1.000      1.000

15001211 15   Corn, field, meal-babyfood         0.030000   1.000      1.000

15001220 15   Corn, field, bran                  0.030000   1.000      1.000

15001230 15   Corn, field, starch                0.030000   1.000      1.000

15001231 15   Corn, field, starch-babyfood       0.030000   1.000      1.000

15001240 15   Corn, field, syrup                 0.030000   1.000      1.500

15001241 15   Corn, field, syrup-babyfood        0.030000   1.000      1.500

15001250 15   Corn, field, oil                   0.030000   1.000      1.000

15001251 15   Corn, field, oil-babyfood          0.030000   1.000      1.000

15001260 15   Corn, pop                          0.030000   1.000      1.000

15001270 15   Corn, sweet                        0.030000   1.000      1.000

15001271 15   Corn, sweet-babyfood               0.030000   1.000      1.000

95001280 O    Cottonseed, oil                    0.030000   1.000      1.000

95001281 O    Cottonseed, oil-babyfood           0.030000   1.000      1.000

11001290 11   Crabapple                          0.030000   1.000      1.000

14001550 14   Filbert                            0.030000   1.000      1.000

14001560 14   Filbert, oil                       0.030000   1.000      1.000

23001690 M    Goat, meat                         0.010000   1.000      1.000

23001700 M    Goat, meat byproducts              0.020000   1.000      1.000

23001710 M    Goat, fat                          0.010000   1.000      1.000

23001720 M    Goat, kidney                       0.010000   1.000      1.000

23001730 M    Goat, liver                        0.800000   1.000      1.000

95001750 O    Grape                              0.030000   1.000      1.000

95001760 O    Grape, juice                       0.030000   1.000      1.200

95001761 O    Grape, juice-babyfood              0.030000   1.000      1.200

95001770 O    Grape, leaves                      0.030000   1.000      1.000

95001780 O    Grape, raisin                      0.030000   1.000      4.300

95001790 O    Grape, wine and sherry             0.030000   1.000      1.000

10001800 10   Grapefruit                         0.030000   1.000      1.000

10001810 10   Grapefruit, juice                  0.030000   1.000      2.100

06031820 6C   Guar, seed                         0.030000   1.000      1.000

06031821 6C   Guar, seed-babyfood                0.030000   1.000      1.000

14001850 14   Hickory nut                        0.030000   1.000      1.000

24001890 M    Horse, meat                        0.010000   1.000      1.000

10001970 10   Kumquat                            0.030000   1.000      1.000

10001990 10   Lemon                              0.030000   1.000      1.000

10002000 10   Lemon, juice                       0.030000   1.000      2.000

10002001 10   Lemon, juice-babyfood              0.030000   1.000      2.000

10002010 10   Lemon, peel                        0.030000   1.000      1.000

06032030 6C   Lentil, seed                       0.030000   1.000      1.000

10002060 10   Lime                               0.030000   1.000      1.000

10002070 10   Lime, juice                        0.030000   1.000      2.000

10002071 10   Lime, juice-babyfood               0.030000   1.000      2.000

11002100 11   Loquat                             0.030000   1.000      1.000

14002130 14   Macadamia nut                      0.030000   1.000      1.000

27002220 D    Milk, fat                          0.010000   1.000      1.000

27002221 D    Milk, fat - baby food/infant for   0.010000   1.000      1.000

27012230 D    Milk, nonfat solids                0.010000   1.000      1.000

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000      1.000

27022240 D    Milk, water                        0.010000   1.000      1.000

27022241 D    Milk, water-babyfood/infant form   0.010000   1.000      1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000      1.000

15002260 15   Millet, grain                      0.030000   1.000      1.000

12002300 12   Nectarine                          0.030000   1.000      1.000

15002310 15   Oat, bran                          0.030000   1.000      1.000

15002320 15   Oat, flour                         0.030000   1.000      1.000

15002321 15   Oat, flour-babyfood                0.030000   1.000      1.000

15002330 15   Oat, groats/rolled oats            0.030000   1.000      1.000

15002331 15   Oat, groats/rolled oats-babyfood   0.030000   1.000      1.000

10002400 10   Orange                             0.030000   1.000      1.000

10002410 10   Orange, juice                      0.030000   1.000      1.800

10002411 10   Orange, juice-babyfood             0.030000   1.000      1.800

10002420 10   Orange, peel                       0.030000   1.000      1.000

06022550 6B   Pea, succulent                     0.030000   1.000      1.000

06022551 6B   Pea, succulent-babyfood            0.030000   1.000      1.000

06032560 6C   Pea, dry                           0.030000   1.000      1.000

06032561 6C   Pea, dry-babyfood                  0.030000   1.000      1.000

06012570 6A   Pea, edible podded, succulent      0.030000   1.000      1.000

06032580 6C   Pea, pigeon, seed                  0.030000   1.000      1.000

06022590 6B   Pea, pigeon, succulent             0.030000   1.000      1.000

12002600 12   Peach                              0.030000   1.000      1.000

12002601 12   Peach-babyfood                     0.030000   1.000      1.000

12002610 12   Peach, dried                       0.030000   1.000      7.000

12002611 12   Peach, dried-babyfood              0.030000   1.000      7.000

12002620 12   Peach, juice                       0.030000   1.000      1.500

12002621 12   Peach, juice-babyfood              0.030000   1.000      1.500

11002660 11   Pear                               0.030000   1.000      1.000

11002661 11   Pear-babyfood                      0.030000   1.000      1.000

11002670 11   Pear, dried                        0.030000   1.000      6.250

11002680 11   Pear, juice                        0.030000   1.000      1.000

11002681 11   Pear, juice-babyfood               0.030000   1.000      1.000

14002690 14   Pecan                              0.030000   1.000      1.000

14002820 14   Pistachio                          0.030000   1.000      1.000

12002850 12   Plum                               0.030000   1.000      1.000

12002851 12   Plum-babyfood                      0.030000   1.000      1.000

12002860 12   Plum, prune, fresh                 0.030000   1.000      1.000

12002861 12   Plum, prune, fresh-babyfood        0.030000   1.000      1.000

12002870 12   Plum, prune, dried                 0.030000   1.000      5.000

12002871 12   Plum, prune, dried-babyfood        0.030000   1.000      5.000

12002880 12   Plum, prune, juice                 0.030000   1.000      1.400

12002881 12   Plum, prune, juice-babyfood        0.030000   1.000      1.400

25002900 M    Pork, meat                         0.010000   1.000      1.000

25002901 M    Pork, meat-babyfood                0.010000   1.000      1.000

25002910 M    Pork, skin                         0.010000   1.000      1.000

25002920 M    Pork, meat byproducts              0.020000   1.000      1.000

25002921 M    Pork, meat byproducts-babyfood     0.020000   1.000      1.000

25002930 M    Pork, fat                          0.010000   1.000      1.000

25002931 M    Pork, fat-babyfood                 0.010000   1.000      1.000

25002940 M    Pork, kidney                       0.010000   1.000      1.000

25002950 M    Pork, liver                        0.800000   1.000      1.000

10003070 10   Pummelo                            0.030000   1.000      1.000

11003100 11   Quince                             0.030000   1.000      1.000

29003120 M    Rabbit, meat                       0.010000   1.000      1.000

15003230 15   Rice, white                        0.030000   1.000      1.000

15003231 15   Rice, white-babyfood               0.030000   1.000      1.000

15003240 15   Rice, brown                        0.030000   1.000      1.000

15003241 15   Rice, brown-babyfood               0.030000   1.000      1.000

15003250 15   Rice, flour                        0.030000   1.000      1.000

15003251 15   Rice, flour-babyfood               0.030000   1.000      1.000

15003260 15   Rice, bran                         0.030000   1.000      1.000

15003261 15   Rice, bran-babyfood                0.030000   1.000      1.000

15003280 15   Rye, grain                         0.030000   1.000      1.000

15003290 15   Rye, flour                         0.030000   1.000      1.000

26003390 M    Sheep, meat                        0.010000   1.000      1.000

26003391 M    Sheep, meat-babyfood               0.010000   1.000      1.000

26003400 M    Sheep, meat byproducts             0.010000   1.000      1.000

26003410 M    Sheep, fat                         0.010000   1.000      1.000

26003411 M    Sheep, fat-babyfood                0.010000   1.000      1.000

26003420 M    Sheep, kidney                      0.010000   1.000      1.000

26003430 M    Sheep, liver                       0.010000   1.000      1.000

15003440 15   Sorghum, grain                     0.030000   1.000      1.000

15003450 15   Sorghum, syrup                     0.030000   1.000      1.000

06003470 6    Soybean, seed                      0.030000   1.000      1.000

06003480 6    Soybean, flour                     0.030000   1.000      1.000

06003481 6    Soybean, flour-babyfood            0.030000   1.000      1.000

06003490 6    Soybean, soy milk                  0.030000   1.000      1.000

06003491 6    Soybean, soy milk-babyfood or in   0.030000   1.000      1.000

06003500 6    Soybean, oil                       0.030000   1.000      1.000

06003501 6    Soybean, oil-babyfood              0.030000   1.000      1.000

20003640 20   Sunflower, seed                    1.000000   1.000      1.000

20003650 20   Sunflower, oil                     1.000000   1.000      1.000

20003651 20   Sunflower, oil-babyfood            1.000000   1.000      1.000

10003690 10   Tangerine                          0.030000   1.000      1.000

10003700 10   Tangerine, juice                   0.030000   1.000      1.000

15003810 15   Triticale, flour                   0.030000   1.000      1.000

15003811 15   Triticale, flour-babyfood          0.030000   1.000      1.000

14003910 14   Walnut                             0.030000   1.000      1.000

86010000 O    Water, direct, all sources         0.173000   1.000      1.000

86020000 O    Water, indirect, all sources       0.173000   1.000      1.000

15004010 15   Wheat, grain                       0.030000   1.000      1.000

15004011 15   Wheat, grain-babyfood              0.030000   1.000      1.000

15004020 15   Wheat, flour                       0.030000   1.000      1.000

15004021 15   Wheat, flour-babyfood              0.030000   1.000      1.000

15004030 15   Wheat, germ                        0.030000   1.000      1.000

15004040 15   Wheat, bran                        0.030000   1.000      1.000

15004050 15   Wild rice                          0.030000   1.000      1.000

Chronic Results File.

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for SAFLUFENACIL                     (1994-98 data)

Residue file name: C:\Documents and Settings\gkramer\My Documents\GK\%Saflufenacil\Saflufenacil_Chronic.R98

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Analysis Date 04-16-2009/13:39:38     Residue file dated: 04-14-2009/13:21:45/8

Reference dose (RfD, Chronic) = .046 mg/kg bw/day

======================================================================== =======

                    Total exposure by population subgroup

------------------------------------------------------------------------ -------

                                                    Total Exposure

                                         -----------------------------------

          Population                         mg/kg             Percent of

           Subgroup                       body wt/day             Rfd

--------------------------------------   -------------       ---------------

U.S. Population (total)                     0.004043                 8.8%

U.S. Population (spring season)             0.004010                 8.7%

U.S. Population (summer season)             0.004310                 9.4%

U.S. Population (autumn season)             0.003924                 8.5%

U.S. Population (winter season)             0.003925                 8.5%

Northeast region                            0.003754                 8.2%

Midwest region                              0.004086                 8.9%

Southern region                             0.003832                 8.3%

Western region                              0.004594                10.0%

Hispanics                                   0.004601                10.0%

Non-hispanic whites                         0.003939                 8.6%

Non-hispanic blacks                         0.003872                 8.4%

Non-hisp/non-white/non-black                0.004929                10.7%

All infants (< 1 year)                      0.012951                28.2%

Nursing infants                             0.004831                10.5%

Non-nursing infants                         0.016032                34.9%

Children 1-6  yrs                           0.006287                13.7%

Children 7-12 yrs                           0.003916                 8.5%

Females 13-19 (not preg or nursing)         0.002897                 6.3%

Females 20+ (not preg or nursing)           0.003884                 8.4%

Females 13-50 yrs                           0.003827                 8.3%

Females 13+ (preg/not nursing)              0.003875                 8.4%

Females 13+ (nursing)                       0.005414                11.8%

Males 13-19 yrs                             0.003081                 6.7%

Males 20+ yrs                               0.003535                 7.7%

Seniors 55+                                 0.003818                 8.3%

Children 1-2 yrs                            0.006895                15.0%

Children 3-5 yrs                            0.006176                13.4%

Children 6-12 yrs                           0.004141                 9.0%

Youth 13-19 yrs                             0.003002                 6.5%

Adults 20-49 yrs                            0.003672                 8.0%

Adults 50+ yrs                              0.003821                 8.3%

Females 13-49 yrs                           0.003659                 8.0%

Saflufenacil		        Dietary Exposure and Risk Assessment			    DP Number:  364183

________________________________________________________________________ ______________

Page   PAGE  4  of   NUMPAGES  18