[Federal Register Volume 82, Number 70 (Thursday, April 13, 2017)]
[Rules and Regulations]
[Page 17754]
[FR Doc No: 2017-07516]

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DEPARTMENT OF HOMELAND SECURITY

Coast Guard

33 CFR Part 165

[Docket No. USCG-2017-0091]

Safety Zone; Monongahela 4th of July Celebration, Monongahela
River Miles 32.0 to 33.0, Monongahela, PA

AGENCY: Coast Guard, DHS.

ACTION: Notice of enforcement of regulation.

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SUMMARY: The Coast Guard will enforce the subject safety zone for the
Monongahela Area Chamber of Commerce's Monongahela 4th of July
Celebration on the Monongahela River, from mile marker (MM) 32.0 to MM
33.0, extending the entire width of the river. The zone is needed to
protect vessels transiting the area and event spectators from the
hazards associated with the Celebration's land-based firework display.
During the enforcement period, entry into, transiting, or anchoring in
the safety zone is prohibited to all vessels not registered with the
sponsor as participants or official patrol vessels, unless specifically
authorized by the Captain of the Port Pittsburgh (COTP) or a designated
representative.

DATES: The regulations in 33 CFR 165.801 Table 1, Sector Ohio Valley,
No. 46 will be enforced from 9:15 p.m. until 11 p.m., on July 4, 2017
with a rain date of July 5, 2017.

FOR FURTHER INFORMATION CONTACT: If you have questions about this
notice of enforcement, call or email MST1 Jennifer Haggins, Marine
Safety Unit Pittsburgh, U.S. Coast Guard; telephone<PHONE_NUMBER>, email
<EMAIL_ADDRESS>
SUPPLEMENTARY INFORMATION: The Coast Guard will enforce the Safety Zone
for the Monongahela Area Chamber of Commerce's Monongahela 4th of July
Celebration on the Monongahela River, listed in 33 CFR 165.801 Table 1,
Sector Ohio Valley, No. 46 from 9:15 p.m. to 11 p.m. on July 4, 2017
with a rain date of July 5, 2017. Entry into the safety zone is
prohibited unless authorized by the COTP or a designated
representative. Persons or vessels desiring to enter into or passage
through the safety zone must request permission from the COTP or a
designated representative. If permission is granted, all persons and
vessels shall comply with the instructions of the COTP or designated
representative.
    This notice of enforcement is issued under authority of 33 CFR
165.801 and 5 U.S.C. 552(a). In addition to this notice in the Federal
Register, the Coast Guard will provide the maritime community with
advance notification of this enforcement period via Local Notice to
Mariners and updates via Marine Information Broadcasts.

    Dated: March 21, 2017.
L. McClain, Jr.,
Commander, U.S. Coast Guard, Captain of the Port Pittsburgh.
[FR Doc. 2017-07516 Filed 4-12-17; 8:45 am]
BILLING CODE 9110-04-P


July 7   10, 2003 Episode ° Plots provide ozone concentration and wind vectors ID Description AP Apex JN Jean JO Joe Neal MQ Mesquite PL Hendersen PV Palo Verde School LV Las Vegas Airport NE Nellis Air Force CAL CalWash 3 Monitoring Stations


[Federal Register: May 9, 2007 (Volume 72, Number 89)]
[Notices]
[Page 26352]
[DOCID:fr09my07-59]

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DEPARTMENT OF ENERGY

Federal Energy Regulatory Commission

[Docket No. RP07-420-000]

Stingray Pipeline Company, L.L.C.; Notice of Proposed Changes in
FERC Gas Tariff

May 2, 2007.
    Take notice that on April 30, 2007, Stingray Pipeline Company,
L.L.C. (Stingray) tendered for filing as part of Stingray's FERC Gas
Tariff, Third Revised Volume No. 1, the following tariff sheets, with
an effective date of May 1, 2007:

Third Revised Sheet No. 140A
Second Revised Sheet No. 302A
Second Revised Sheet No. 302B
First Revised Sheet No. 302C
Second Revised Sheet No. 305B
First Revised Sheet No. 305C
Original Sheet No. 305D
First Revised Sheet No. 318
First Revised Sheet No. 319
First Revised Sheet No. 320
Second Revised Sheet No. 321
First Revised Sheet No. 322

    Any person desiring to intervene or to protest this filing must
file in accordance with Rules 211 and 214 of the Commission's Rules of
Practice and Procedure (18 CFR 385.211 and 385.214). Protests will be
considered by the Commission in determining the appropriate action to
be taken, but will not serve to make protestants parties to the
proceeding. Any person wishing to become a party must file a notice of
intervention or motion to intervene, as appropriate. Such notices,
motions, or protests must be filed in accordance with the provisions of
Section 154.210 of the Commission's regulations (18 CFR 154.210).
Anyone filing an intervention or protest must serve a copy of that
document on the Applicant. Anyone filing an intervention or protest on
or before the intervention or protest date need not serve motions to
intervene or protests on persons other than the Applicant.
    The Commission encourages electronic submission of protests and
interventions in lieu of paper using the ``eFiling'' link at http://www.ferc.gov.
 Persons unable to file electronically should submit an

original and 14 copies of the protest or intervention to the Federal
Energy Regulatory Commission, 888 First Street, NE., Washington, DC
20426.
    This filing is accessible on-line at http://www.ferc.gov, using the

``eLibrary'' link and is available for review in the Commission's
Public Reference Room in Washington, DC. There is an ``eSubscription''
link on the Web site that enables subscribers to receive e-mail
notification when a document is added to a subscribed docket(s). For
assistance with any FERC Online service, please e-mail
<EMAIL_ADDRESS>or call<PHONE_NUMBER> (toll free). For

TTY, call<PHONE_NUMBER>.

Kimberly D. Bose,
Secretary.
 [FR Doc. E7-8838 Filed 5-8-07; 8:45 am]

BILLING CODE 6717-01-P


  SEQ CHAPTER \h \r 1 ICF Consulting Review of Fueta et al. (2002)

ICF has been asked to review the journal article, “Hyperexcitability
and changes in activities of Ca2+/calmodulin-dependent kinase II and
mitogen-activated protein kinase in the hippocampus of rats exposed to
1-bromopropane” by Fueta and coworkers (2003).  Details regarding the
study design, results, and major conclusions are detailed in the
following text.  Further, ICF will discuss the relevance of this study
to other studies in rodents and will discuss whether this study allows
for the identification of an alternate NOAEL/LOAEL for the determination
of an Acceptable Exposure Limit for n-propylbromide (i.e.,
1-bromopropane).

Background and Study Purpose

The hippocampus is a section of the brain that in the human is located
within the temporal lobe.  Damage to it or any region that is connected
to it results in the inability to learn new information.  The
hippocampus is divided into four regions:  CA1, CA2, CA3, and CA4.  CA1
and CA3 are very important in hippocampal processes; it is thought that
cells in these regions are involved in the consolidation of long-term
memories, in particular for spatial location.  This learning may occur
via "long-term potentiation" which is an increase in the excitability of
a neuron to a unique synaptic input caused by repeated high-frequency
activity at that input.  Further, learning experiences involving the
hippocampus and associated brain structures induce biochemical changes
that underlie long-term potentiation.  The purpose of this study was to
determine if hyperexcitability in the hippocampus and dentate gyrus
(another brain structure that is part of the hippocampal formation)
caused by 1-bromopropane exposure results in intercellular signaling
changes in the following proteins: Ca2+/calmodulin-dependent kinase II
(CAMKII); mitogen-activated protein kinase (MAPK), and protein kinase C
(PKC).  The first two proteins (CAMKII and MAPK) have been implicated as
important for learning and memory.

Study Design

Male Wistar rats at 7 weeks of age were exposed to target concentrations
of 0 (fresh air) or 700 ppm n-propylbromide (12/group) in whole-body
inhalation chambers for 6 hours/day, 5 days/week for 8 weeks.  Measured
concentrations of the nPB, if analyzed, were not reported. Hippocampal
slices were obtained from the brains of six rats from each exposure
group.  Four or six slices were obtained from each rat and perfused with
an artificial cerebrospinal fluid.  After stabilization of the slices,
microelectrodes were inserted into the CA1 or dentate gyrus.
Paired-pulse stimulation was conducted, and paired-pulse inhibition or
facilitation was measured (the depression or potentiation in the
responses to the second stimulation relative to those in the first
stimulation).  Presence of active (phosphorylated) enzymes in
homogenized hippocampal tissue from the remaining 6 rats/group was
assayed using immunoblotting techniques with antibodies raised to the
following enzymes:  CaMKII, MAPK, active MAPK, and PKCα.

Study Results

Exposure to 700 ppm nPB for 8 weeks resulted in a significant decrease
in paired-pulse inhibition at 5 ms intervals in the CA1 region and at
both 10 and 20 ms intervals in the dentate gyrus.  No effects were seen
at higher intervals in these two regions.  The study authors indicated
they had published previous results with rats exposed to 1500 ppm nPB;
the results in these animals was not as great as those exposed to the
higher concentration.

n the total amounts of CaMKIIα (by 29%) and CaMKIIβ (by 46%) subunits,
but no increase in the phosphorylated versions of these subunits.  In
fact, phosphorylated CaMKIIβ was significantly decreased (by 22%)
following nPB exposure.  Phosphorylated MAPK was increased by 28%
compared to the control response, with no concomitant change in overall
MAPK concentration.  Total and phosphorylated PKCα levels were
unaffected.

Discussion

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mpus and dentate gyrus.  However, this increase was not associated with
behavioral affects (according to the study authors) and could not be
causally linked with an increase CaMKII activity.  There may be a link
between the increase in overall CaMKII expression and the
hyperexcitability.  The data suggest that intercellular signaling is
modified, as active levels of MAPK were increased.  These results cannot
be used to provide an alternative AEL as only one exposure concentration
was used (which is higher than the level already associated with other
toxic effects in rodents [400 ppm]) and a shorter exposure duration (8
weeks) was used than the other subchronic studies that have shown
effects (13 weeks).

Reference

Fueta Y, Fukunaga K, Ishidao T, and Hori H. 2002.  Hyperexcitability and
changes in activities of Ca2+/calmodulin-dependent kinase II and
mitogen-activated protein kinase in the hippocampus of rats exposed to
1-bromopropane.  Life Sci 72:521-529.