  SEQ CHAPTER \h \r 1

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

DATE:  	03-OCT-2007

SUBJECT:	Fluroxypyr Chronic Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Section 3 Registration Action to Support New Uses on Pome Fruits and Millet

PC Code:	128968 & 128959	Decision Number:  373266

DP Number:	D344532

REVIEWER:	Donna S. Davis, Chemist

RRB1/Health Effects Division (7509P)

THROUGH:	David Soderberg, Chemist

Sheila Piper, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

and

Christine L. Olinger, Branch Senior Scientist

Michael S. Metzger, Chief

RRB1/Health Effects Division (7509P)

TO:		Shaja Brothers, Risk Assessor

		Barbara Madden, Minor Use Team Leader

		Dan Rosenblatt, Chief

		RIMUERB/Registration Division (7505P)

Executive Summary

A chronic dietary (food and drinking water) exposure and risk assessment was conducted using the Dietary Exposure Evaluation Model DEEM-FCID™, Version 2.03 which use food consumption data from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998.  The analysis was performed to support Section 3 requests for new uses of fluroxypyr in/on pome fruit and millet.

Chronic Dietary Exposure Results and Characterization

An unrefined, Tier 1 chronic dietary exposure and risk assessment was conducted incorporating both food and water residues.  For all foods, the assessment assumed 100% crop treated and tolerance level residues for all existing and new uses of fluroxypyr.  The drinking water inputs were based on modeled surface water values from the scenario likely to provide the highest estimated environmental concentration.  These assumptions result in highly conservative estimates of dietary exposure and risk.  Typically, HED has concerns regarding dietary risk when the exposure estimates exceed 100% of the chronic population adjusted dose (cPAD).  Even with the conservative assumptions noted above, risk estimates associated with the established and new uses of fluroxypyr are significantly below HED’s level of concern.  The estimated exposure (food and water) to the U.S. population from the existing and proposed new uses of fluroxypyr resulted in an estimated risk equivalent to < 1% of the chronic population adjusted dose (cPAD).  The most highly exposed subpopulation was children 1 – 2 years of age with an estimated exposure equivalent to 1.4% of the cPAD.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population adjusted dose (PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link:      HYPERLINK "http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf"  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for fluroxypyr was conducted by Amelia Acierto (8/1/2006, DP 328732).

II.	Residue Information

Registered and Proposed Fluroxypyr Tolerances

Tolerances have been established for the combined residues of fluroxypyr 1-methylheptyl ester [1-methylheptyl ((4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy)acetate] and its metabolite fluroxypyr [((4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy)acetic acid] under 40 CFR 180.535. The established tolerances for plant commodities range from 0.02 ppm (field corn grain, sweet corn K+CWHR, and sorghum grain) to 160 ppm (grass hay) [40 CFR 180.535(a)].  The established tolerances for livestock commodities range from 0.1 ppm (fat, meat, and meat byproducts) to 1.5 ppm (kidney).

New uses for fluroxypyr are proposed for pome fruits and millet.  The pome fruit use provides for a single application of fluroxypyr to the orchard floor up to 14-days before harvest.  The millet use allows for up to two post emergence aerial or ground broadcast applications to millet up to 40 days before grain harvest.  HED has recommended that a tolerance of 0.02 ppm be established for pome fruit and 0.5 ppm for millet grain.

Residue Data used for Chronic Assessment:

™  default concentration values for dried commodities were used for the analysis.

 Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED).  EEC values were provided to HED in the memorandum entitled Drinking Water Assessment for Fluroxypyr new Uses on Pome Fruit and Millet (DP 336179, Johnathan Angier, 9/26/07).  Water residues were incorporated in the DEEM-FCID™  into the food categories “water, direct, all sources” and “water, indirect, all sources.”

EFED currently has no monitoring data for fluroxypyr in surface or groundwater.  The Tier II screening models PRZM and EXAMS with the Index Reservoir and Percent Crop Area adjustment (IR-PCA PRZM/EXAMS) were used to determine estimated surface water concentrations of fluroxypyr. The Screening Concentration in Groundwater (SCI-GROW) model was used to estimate groundwater concentrations for fluroxypyr. These models and their descriptions are available at the EPA internet site:   HYPERLINK "http://www.epa.gov/oppefed1/models/water/"  http://www.epa.gov/oppefed1/models/water/ .

EFED previously conducted an analysis to determine drinking water estimated environmental concentrations (EECs) of fluroxypyr  based on application to rangeland and pastureland grasses (D292471, Ibrahim Abdel-Saheb, 8/13/03).  Subsequently, EFED conducted an analysis to determine EECs for fluroxypyr based on the newly proposed uses that are the subject of this petition.  Modeled surface and drinking water numbers for the rangeland and pastureland grasses, pome fruit and millet uses are summarized in the table, below.  EFED has concluded that the rangeland and pastureland uses continue to result in the highest surface water numbers.  Since the surface water EECs are significantly higher than the ground water EECs, the annual mean surface water residue derived from the pastureland/rangeland scenario was used in the chronic dietary risk assessment.

Table 1.  Estimated Environmental Concentrations for Fluroxypyr

Duration	Model EECs (ppb)

Rangeland/Pastureland (Alfalfa)

Surface water/ peak (90th percentile annual daily max.)	32.9

Surface water/ 90th percentile  (annual mean)	3.28

Surface water (36-year overall mean )	1.76

Groundwater 	0.04

Pome Fruit (NC Apple)

Surface water/ peak (90th percentile annual daily max.)	19.0

Surface water/ 90th percentile  (annual mean)	0.25

Surface water (36-year overall mean )	0.09

Groundwater 	0.05

Millet (TX sorghum)

Surface water/ peak (90th percentile annual daily max.)	15.4

Surface water/ 90th percentile  (annual mean)	0.21

Surface water (36-year overall mean )	0.06

Groundwater 	0.03

Note:  Bolded value is EEC used for the chronic dietary exposure and risk assessment.

IV.	DEEM-FCID™ Program and Consumption Information

Fluroxypyr chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID™, Version 2.03, which incorporates consumption data from USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

V.	Toxicological Information

The toxicology database is considered complete for the purposes of this risk assessment.  The Fluroxypyr Risk Assessment Team has reviewed the toxicity database and has concluded that the doses and endpoints previously selected for risk assessment purposes remain consistent with current HED policy and are appropriate for the routes and durations of exposure anticipated from the existing and newly proposed uses of fluroxypyr.

Fluroxypyr has low acute toxicity by the oral and dermal routes and moderate acute toxicity by the inhalation route.  It is not irritating to the skin, nor is it a dermal sensitizer; however, it is a mild eye irritant.  Subchronic and chronic studies in rats, mice, and dogs indicate that the target organ is the kidney.  Developmental studies and the reproductive study in rats indicated maternal toxicity as increased kidney weight, decreased body-weight gain and food consumption.  In developmental studies with both rats and rabbits, deaths at high doses were observed.  There was no evidence (quantitative/qualitative) of increased susceptibility following in utero exposure to fluroxypyr in rats and rabbits, or following pre and/or postnatal exposure in rats. A review of acceptable carcinogenicity and mutagenicity studies provide no indication that fluroxypyr is carcinogenic or mutagenic.

Endpoints for risk assessment were based on kidney effects seen in the database.  Doses selected for dietary risk assessment purposes are summarized below.  The FQPA safety factor was reduced to 1X since the toxicity database was considered complete, there were no residual uncertainties for pre-and/or post natal toxicity, no evidence of neurotoxicity or neuropathology was found, and the estimated exposures were not likely to underestimate risk.

Table 2. Summary of Toxicological Doses and Endpoints for Fluroxypyr for Use in Human Risk Assessments

Exposure

Scenario	Dose Used in Risk Assessment, UF 	FQPA SF* and Level of Concern for Risk Assessment	Study and Toxicological Effects

Acute Dietary

(All populations)	No adverse effects were identified following a single oral dose and there are no developmental concerns noted in the database.  A risk assessment for this route and duration is not required.

Chronic Dietary

(All populations)	NOAEL= 100 mg/kg/day

UF = 100

chronic RfD =

1 mg/kg/day

	FQPA SF = 1x

chronic PAD =

1 mg/kg/day	Chronic/Onco-Rat

LOAEL = 500 mg/kg/day based on kidney effects, which include increased kidney weights, alterations in clinical chemistry parameters indicative of impaired renal functions, and increase in severity of chronic progressive  glomerulonephropathy (both sexes).

Cancer (oral, dermal, inhalation)			Classification: “not likely” human carcinogen

UF = uncertainty factor, FQPA SF = FQPA safety factor, NOAEL = no observed adverse effect level, LOAEL = lowest observed adverse effect level, PAD = population adjusted dose, RfD = reference dose, NA = Not Applicable

VI.	Results/Discussion

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of the cPAD.  The DEEM-FCID™ analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results of the chronic dietary assessment reported in Table 3 are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years.

Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in the summary table below.

Table 3.  Summary of Chronic Dietary (Food and Drinking Water) Exposure and Risk for Fluroxypyr

Population Subgroup	Chronic Dietary

	Dietary Exposure

(mg/kg/day)	% cPAD

General U.S. Population	0.003278	<1

All Infants (< 1 year old)	0.004983	<1

Children 1-2 years old	0.014050	1.4

Children 3-5 years old	0.009938	1.0

Children 6-12 years old	0.006082	<1

Youth 13-19 years old	0.002914	<1

Adults 20-49 years old	0.002036	<1

Adults 50+ years old	0.001816	<1

Females 13-49 years old	0.002003	<1

VII.	Characterization of Inputs/Outputs

The Tier 1 chronic dietary assessment is considered to be highly conservative, using tolerance level residues and 100% crop treated information for all commodities, as well as default drying concentration factors.  The results of the dietary risk assessment are unlikely to underestimate risk.

VIII.	Conclusions

An unrefined, Tier 1 chronic dietary exposure assessment using tolerance level residues and 100% crop treated incorporating modeled water residues was conducted to support new uses on pome fruit and millet.  The assessment is considered highly conservative.  Exposures from fluroxypyr for the U.S. population resulted in an estimated risk equivalent to <1% of the cPAD.  The most highly exposed population subgroup is children 1 – 2 years of age with an exposure equivalent to an estimated risk of 1.4% of the cPAD.

IX.		List of Attachments

Chronic Food and Water Residue Input file.

Chronic Results file.

Attachment 1.  Chronic Food and Water Residue Input file.

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for FLUROXYPYR                         1994-98 data

Residue file: C:\Documents and Settings\ddavis05\DEEM files\Flur_chron_fw.R98

                                                               Adjust. #2 used

Analysis Date 10-03-2007             Residue file dated: 10-03-2007/08:06:24/8

Reference dose (RfD) = 1 mg/kg bw/day

------------------------------------------------------------------------ --------

Food Crop                                       Residue       Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)

                                                             #1         #2

-------- ---- -------------------------------   ---------- ------     ------   -------

11000070 11   Apple, fruit with peel             0.020000   1.000      1.000   New Us

  Full comment: New Use

11000080 11   Apple, peeled fruit                0.020000   1.000      1.000   New Us

  Full comment: New Use

11000081 11   Apple, peeled fruit-babyfood       0.020000   1.000      1.000   New Us

  Full comment: New Use

11000090 11   Apple, dried                       0.020000   8.000      1.000   New Us

  Full comment: New Use

11000091 11   Apple, dried-babyfood              0.020000   8.000      1.000   New Us

  Full comment: New Use

11000100 11   Apple, juice                       0.020000   1.000      1.000   New Us

  Full comment: New Use

11000101 11   Apple, juice-babyfood              0.020000   1.000      1.000   New Us

  Full comment: New Use

11000110 11   Apple, sauce                       0.020000   1.000      1.000   New Us

  Full comment: New Use

11000111 11   Apple, sauce-babyfood              0.020000   1.000      1.000   New Us

  Full comment: New Use

15000250 15   Barley, pearled barley             0.500000   1.000      1.000

15000251 15   Barley, pearled barley-babyfood    0.500000   1.000      1.000

15000260 15   Barley, flour                      0.500000   1.000      1.000

15000261 15   Barley, flour-babyfood             0.500000   1.000      1.000

15000270 15   Barley, bran                       0.500000   1.000      1.000

21000440 M    Beef, meat                         0.100000   1.000      1.000

21000441 M    Beef, meat-babyfood                0.100000   1.000      1.000

21000450 M    Beef, meat, dried                  0.100000   1.920      1.000

21000460 M    Beef, meat byproducts              0.100000   1.000      1.000

21000461 M    Beef, meat byproducts-babyfood     0.100000   1.000      1.000

21000470 M    Beef, fat                          0.100000   1.000      1.000

21000471 M    Beef,fat-babyfood                  0.100000   1.000      1.000

21000480 M    Beef, kidney                       1.500000   1.000      1.000

21000490 M    Beef, liver                        0.100000   1.000      1.000

21000491 M    Beef, liver-babyfood               0.100000   1.000      1.000

15001200 15   Corn, field, flour                 0.050000   1.000      1.000

15001201 15   Corn, field, flour-babyfood        0.050000   1.000      1.000

15001210 15   Corn, field, meal                  0.050000   1.000      1.000

15001211 15   Corn, field, meal-babyfood         0.050000   1.000      1.000

15001220 15   Corn, field, bran                  0.050000   1.000      1.000

15001230 15   Corn, field, starch                0.050000   1.000      1.000

15001231 15   Corn, field, starch-babyfood       0.050000   1.000      1.000

15001240 15   Corn, field, syrup                 0.050000   1.000      1.000

15001241 15   Corn, field, syrup-babyfood        0.050000   1.000      1.000

15001250 15   Corn, field, oil                   0.050000   1.000      1.000

15001251 15   Corn, field, oil-babyfood          0.050000   1.000      1.000

15001260 15   Corn, pop                          0.050000   1.000      1.000

15001270 15   Corn, sweet                        0.050000   1.000      1.000

15001271 15   Corn, sweet-babyfood               0.050000   1.000      1.000

11001290 11   Crabapple                          0.020000   1.000      1.000   New Us

  Full comment: New Use

03001640 3    Garlic                             0.030000   1.000      1.000

03001650 3    Garlic, dried                      0.030000   1.000      1.000

03001651 3    Garlic, dried-babyfood             0.030000   1.000      1.000

23001690 M    Goat, meat                         0.100000   1.000      1.000

23001700 M    Goat, meat byproducts              0.100000   1.000      1.000

23001710 M    Goat, fat                          0.100000   1.000      1.000

23001720 M    Goat, kidney                       1.500000   1.000      1.000

23001730 M    Goat, liver                        0.100000   1.000      1.000

24001890 M    Horse, meat                        0.100000   1.000      1.000

11002100 11   Loquat                             0.020000   1.000      1.000   New Us

  Full comment: New Use

28002210 M    Meat, game                         0.100000   1.000      1.000

27002220 D    Milk, fat                          0.300000   1.000      1.000

27002221 D    Milk, fat - baby food/infant for   0.300000   1.000      1.000

27012230 D    Milk, nonfat solids                0.300000   1.000      1.000

27012231 D    Milk, nonfat solids-baby food/in   0.300000   1.000      1.000

27022240 D    Milk, water                        0.300000   1.000      1.000

27022241 D    Milk, water-babyfood/infant form   0.300000   1.000      1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.300000   1.000      1.000

15002260 15   Millet, grain                      0.500000   1.000      1.000   New Us

  Full comment: New Use

15002310 15   Oat, bran                          0.500000   1.000      1.000

15002320 15   Oat, flour                         0.500000   1.000      1.000

15002321 15   Oat, flour-babyfood                0.500000   1.000      1.000

15002330 15   Oat, groats/rolled oats            0.500000   1.000      1.000

15002331 15   Oat, groats/rolled oats-babyfood   0.500000   1.000      1.000

03002370 3    Onion, dry bulb                    0.030000   1.000      1.000

03002371 3    Onion, dry bulb-babyfood           0.030000   1.000      1.000

03002380 3    Onion, dry bulb, dried             0.030000   9.000      1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.030000   9.000      1.000

11002660 11   Pear                               0.020000   1.000      1.000   New Us

  Full comment: New Use

11002661 11   Pear-babyfood                      0.020000   1.000      1.000   New Us

  Full comment: New Use

11002670 11   Pear, dried                        0.020000   8.000      1.000   New Us

  Full comment: New Use

11002680 11   Pear, juice                        0.020000   1.000      1.000   New Us

  Full comment: New Use

11002681 11   Pear, juice-babyfood               0.020000   1.000      1.000   New Us

  Full comment: New Use

25002900 M    Pork, meat                         0.100000   1.000      1.000

25002901 M    Pork, meat-babyfood                0.100000   1.000      1.000

25002910 M    Pork, skin                         0.100000   1.000      1.000

25002920 M    Pork, meat byproducts              0.100000   1.000      1.000

25002921 M    Pork, meat byproducts-babyfood     0.100000   1.000      1.000

25002930 M    Pork, fat                          0.100000   1.000      1.000

25002931 M    Pork, fat-babyfood                 0.100000   1.000      1.000

25002940 M    Pork, kidney                       1.500000   1.000      1.000

25002950 M    Pork, liver                        0.100000   1.000      1.000

11003100 11   Quince                             0.020000   1.000      1.000   New Us

  Full comment: New Use

29003120 M    Rabbit, meat                       0.100000   1.000      1.000

03003380 3    Shallot                            0.030000   1.000      1.000

26003390 M    Sheep, meat                        0.100000   1.000      1.000

26003391 M    Sheep, meat-babyfood               0.100000   1.000      1.000

26003400 M    Sheep, meat byproducts             0.100000   1.000      1.000

26003410 M    Sheep, fat                         0.100000   1.000      1.000

26003411 M    Sheep, fat-babyfood                0.100000   1.000      1.000

26003420 M    Sheep, kidney                      1.500000   1.000      1.000

26003430 M    Sheep, liver                       0.100000   1.000      1.000

15003440 15   Sorghum, grain                     0.020000   1.000      1.000

15003450 15   Sorghum, syrup                     0.020000   1.000      1.000

86010000 O    Water, direct, all sources         0.003300   1.000      1.000

86020000 O    Water, indirect, all sources       0.003300   1.000      1.000

15004010 15   Wheat, grain                       0.500000   1.000      1.000

15004011 15   Wheat, grain-babyfood              0.500000   1.000      1.000

15004020 15   Wheat, flour                       0.500000   1.000      1.000

15004021 15   Wheat, flour-babyfood              0.500000   1.000      1.000

15004030 15   Wheat, germ                        0.500000   1.000      1.000

15004040 15   Wheat, bran                        0.500000   1.000      1.000

Attachment 2.  Chronic Dietary (Food and Water) Results

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for FLUROXYPYR                       (1994-98 data)

Residue file name: C:\Documents and Settings\ddavis05\DEEM files\Flur_chron_fw.R98

                                                     Adjustment factor #2 used.

Analysis Date 10-03-2007/08:07:21     Residue file dated: 10-03-2007/08:06:24/8

Reference dose (RfD, Chronic) = 1 mg/kg bw/day

======================================================================== =======

                    Total exposure by population subgroup

------------------------------------------------------------------------ -------

                                                    Total Exposure

                                         -----------------------------------

          Population                         mg/kg             Percent of

           Subgroup                       body wt/day             Rfd

--------------------------------------   -------------       ---------------

U.S. Population (total)                     0.003278                 0.3%

U.S. Population (spring season)             0.003276                 0.3%

U.S. Population (summer season)             0.003159                 0.3%

U.S. Population (autumn season)             0.003384                 0.3%

U.S. Population (winter season)             0.003288                 0.3%

Northeast region                            0.003334                 0.3%

Midwest region                              0.003467                 0.3%

Southern region                             0.002984                 0.3%

Western region                              0.003490                 0.3%

Hispanics                                   0.003738                 0.4%

Non-hispanic whites                         0.003263                 0.3%

Non-hispanic blacks                         0.002928                 0.3%

Non-hisp/non-white/non-black                0.003421                 0.3%

All infants (< 1 year)               †††〠〮㐰㠹″††††††††⸰┵不牵楳杮椠普 湡獴††††††††††††††〠〮㄰㐶‱††† †††††⸰┲不湯渭牵楳杮椠普湡獴††††††† †††††〠〮㘰㔲′††††††††⸰┶

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Children 1-6  yrs                           0.011045                 1.1%

Children 7-12 yrs                           0.005672                 0.6%

Females 13-19 (not preg or nursing)         0.002478                 0.2%

Females 20+ (not preg or nursing)           0.001814                 0.2%

Females 13-50 yrs                           0.002296                 0.2%

Females 13+ (preg/not nursing)              0.002833                 0.3%

Females 13+ (nursing)                       0.002990                 0.3%

Males 13-19 yrs                             0.003320                 0.3%

Males 20+ yrs                               0.002079                 0.2%

Seniors 55+                                 0.001831                 0.2%

Children 1-2 yrs                            0.014050                 1.4%

Children 3-5 yrs                            0.009938                 1.0%

Children 6-12 yrs                           0.006082                 0.6%

Youth 13-19 yrs                             0.002914                 0.3%

Adults 20-49 yrs                            0.002036                 0.2%

Adults 50+ yrs                              0.001816                 0.2%

Females 13-49 yrs                           0.002003                 0.2%

------------------------------------------------------------------------ -------

Fluroxypyr	Dietary Exposure and Risk Assessment	DP Number: 344532

Page   PAGE  9  of   NUMPAGES  11


[Federal Register Volume 78, Number 22 (Friday, February 1, 2013)]
[Notices]
[Pages 7427-7428]
[FR Doc No: 2013-02215]

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ENVIRONMENTAL PROTECTION AGENCY

[FRL-9775-3]

National and Governmental Advisory Committees to the U.S.
Representative to the Commission for Environmental Cooperation

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of advisory committee meeting teleconference call.

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SUMMARY: Under the Federal Advisory Committee Act, Public Law 92-463,
EPA gives notice of a meeting of the National Advisory Committee (NAC)
and Governmental Advisory Committee (GAC) to the U.S. Representative to
the North American Commission for Environmental Cooperation (CEC). The
National and Governmental Advisory Committees advise the EPA
Administrator in her capacity as the U.S. Representative to the CEC
Council. The Committees are authorized under Articles 17 and 18 of the
North American Agreement on Environmental Cooperation (NAAEC), North
American Free Trade Agreement Implementation Act, Public Law 103-182,
and as directed by Executive Order 12915, entitled ``Federal
Implementation of the North American Agreement on Environmental
Cooperation.'' The NAC is composed of 14 members representing academia,
environmental non-governmental organizations, and private industry. The
GAC consists of 15 members representing state, local, and Tribal
governments. The Committees are responsible for providing advice to the
U.S. Representative on a wide range of strategic, scientific,
technological, regulatory, and economic issues related to
implementation and further elaboration of the NAAEC.
    The purpose of this teleconference is to inform committee members
on the status of Tribes in the U.S., Canada and Mexico. The presenter
will be Mr. James

Anaya, Special Rapparteur on the rights of Indigenous peoples in the
United Nations Office of the High Commissioner for Human Rights. A copy
of the agenda will be posted at http://www.epa.gov/ofacmo/nacgac-page.htm.

DATES: The NAC/GAC will hold a public teleconference on Friday,
February 15, 2013, from 12:30 p.m. to 1:30 p.m. Eastern Standard Time.

ADDRESSES: The meeting will be held at the U.S. EPA East Building, 1201
Constitution Ave. NW., Room 1132, Washington, DC 20004.

FOR FURTHER INFORMATION CONTACT: Oscar Carrillo, Designated Federal
Officer<EMAIL_ADDRESS>202-564-0347, U.S. EPA, Office of
Federal Advisory Committee Management and Outreach (1601-M), 1200
Pennsylvania Avenue NW., Washington, DC 20460.

SUPPLEMENTARY INFORMATION: Requests to make oral comments or to provide
written comments to NAC/GAC should be sent to Oscar Carrillo at
<EMAIL_ADDRESS>by Thursday, February 7, 2013. The meeting is
open to the public, with limited seating on a first-come, first-served
basis. Members of the public wishing to participate in the
teleconference should contact Oscar Carrillo at<EMAIL_ADDRESS>or<PHONE_NUMBER> by February 7, 2013.
    Meeting Access: For information on access or services for
individuals with disabilities, please contact Oscar Carrillo at 202-
564-0347 or<EMAIL_ADDRESS>To request accommodation of a
disability, please contact Oscar Carrillo, preferably at least 10 days
prior to the meeting, to give EPA as much time as possible to process
your request.

    Dated: January 24, 2013.
Oscar Carrillo,
Designated Federal Officer.
[FR Doc. 2013-02215 Filed 1-31-13; 8:45 am]
BILLING CODE 6560-50-P