Page 1 of 20 Reassessment of Commodity Tolerances that are Insignificant Contributors to the N methyl Carbamate Cumulative Risk June 29, 2006 I. Background and Introduction The Food Quality Protection Act ( FQPA) of 1996 requires EPA to consider available information concerning the cumulative effects on human health resulting from exposure to multiple chemicals that have a common mechanism of toxicity. In 2001, EPA concluded that the N methyl carbamate ( NMC) pesticides share a common mechanism of toxicity and therefore require a cumulative assessment under FQPA. The ten pesticides in the NMC common mechanism group are aldicarb, carbaryl, carbofuran, formetanate hydrochloride, methiocarb, methomyl, oxamyl, pirimicarb, propoxur, and thiodicarb. The Agency's tolerance reassessment decisions for these ten NMC pesticides must be based on the interim tolerance reassessment decisions for each individual compound, as well as the NMC cumulative assessment. EPA released the Preliminary Assessment of Cumulative Risk from N Methyl Carbamate Pesticides in August 2005.

As part of its ongoing work to complete the NMC cumulative assessment, EPA has determined that 144 of the NMC tolerances are insignificant contributors to the overall dietary exposure to the NMCs. These commodity/ chemical combinations, when considered together, make such a minor or negligible contribution to the cumulative risk of the NMCs that the addition or subtraction of those uses from the risk cup would have no quantified significance and would therefore have no impact on whether the NMCs as a group meet the FQPA safety standard in section 408( b)( 2) of the Federal Food, Drug and Cosmetic Act ( FFDCA). Because these uses, by themselves, add no meaningful risk, and because, as a result, they will have no effect on the retention or revocation of other NMC tolerances, EPA intends to count these negligible uses as reassessed before the final NMC cumulative assessment is issued. As described in detail below, the Agency has taken a conservative, health protective approach in determining the criteria for this analysis and is thus confident that these tolerances can be considered to be reassessed as required under section 408( q).

For each of the 144 tolerances being reassessed at this time, the Agency has issued an Interim Reregistration Eligibility Decision ( IRED) which found that, apart from consideration of the potential cumulative risks from all of the NMCs, each tolerance would meet the section 408( b)( 2) safety standard. EPA has also considered the impact of these tolerances on the NMC cumulative risks and has determined that they make an insignificant contribution to the overall risks from the NMCs. Therefore, these tolerances will be maintained regardless of the outcome of the NMC cumulative assessment and any potential regulatory action taken as a result of that assessment. Accordingly, EPA believes it is appropriate to consider these 144 tolerances reassessed for the purposes of FQPA section 408( q) as of today's date, June 29, 2006. Draft, Internal, Deliberative.

Page 2 of 20 II. NMC Tolerances Requiring Reassessment under FQPA FQPA required EPA to reassess all tolerances in existence when FQPA became law on August 3, 1996. For the ten pesticides in the NMC common mechanism group, there were a total of 320 tolerances that required reassessment because they were in existence on the day that FQPA was enacted.

To date, ninety two of the 320 NMC tolerances requiring reassessment under FQPA have already been reassessed. The ninety two tolerances include seven methiocarb tolerances, eighty methomyl tolerances, and five thiodicarb tolerances. The methiocarb tolerances are considered reassessed because all methiocarb tolerances were revoked in 1998.1 The methomyl and thiodicarb tolerances are considered reassessed because EPA issued REDs and associated tolerance reassessment decisions for methomyl and thiodicarb in 1998, prior to the Agency's determination that these compounds would be part of the NMC common mechanism group. Please see Table A. 6 in the Appendix for a listing of the reassessed tolerances for methiocarb, methomyl, and thiodicarb.

III. Determination of Insignificant Contributors This section describes the procedures EPA followed to determine the number of NMC tolerances that could be reassessed based on an insignificant contribution to the total NMC risk in food. These NMC tolerances, termed Insignificant Contributors, are the subset of NMC crop/ chemical combinations that, when expressed in terms of index chemical equivalents and considered together as part of a cumulative risk assessment, contribute to only a small fraction of the NMC cumulative risk from food. Such a designation to specific crop/ chemical combinations2 permits the Agency to conclude that the contribution to dietary risk of the NMC tolerances associated with these crop/ chemical combinations is relatively small and that these tolerances can thus be reassessed prior to EPA's issuance of the revised NMC cumulative risk assessment. Only tolerances for NMCs with completed IREDs were eligible for designation as Insignificant Contributors.

The Agency notes that this is a screening level assessment designed to ensure that risk will not be underestimated. EPA fully expects that additional NMC tolerances will be eligible for reassessment in the near future when the Agency issues the revised NMC cumulative assessment, which will use more refined information.

1 63 Federal Register 57067, October 26, 1998. 2 In some cases, a crop/ pesticide combination is really a crop group/ pesticide combination if the tolerance is applicable to a crop group. For example, if a tolerance were established for a given pesticide on citrus fruits, this would be considered a single crop ( group)/ pesticide combination despite the fact that the tolerance applies to all crops in that crop group ( e. g., oranges, grapefruits, lemons, limes, etc.) Draft, Internal, Deliberative.

Page 3 of 20 Hazard/ Relative Potency Factors In the current analysis, EPA used the relative potency factors ( RPFs) and points of departure established in the preliminary cumulative risk assessment ( August 2005) for brain cholinesterase inhibition. For details about the data and methods used to derive these values, please refer to Chapter I. B and associated appendices and data sets in the preliminary cumulative risk assessment ( August 2005) ( available at http:// www. epa. gov/ pesticides/ cumulative). The Agency used benchmark dose ( BMD) methods to estimate the dose expected to result in 10% brain cholinesterase inhibition ( BMD10) in adult rats following acute exposures. EPA calculated RPFs by dividing BMDs for specific pesticides by the BMD for the index chemical, oxamyl.

The Agency anticipates that most of the RPFs and points of departure used in this Insignificant Contributors analysis ( and also in the August 2005 preliminary NMC cumulative assessment) will be substantially similar to those that will be used in the forthcoming revised NMC cumulative assessment. If some values do differ, it will be because the revised cumulative assessment uses values that have been further refined based on recently submitted data.

Dietary Exposure EPA began the process of identifying Insignificant Contributors by performing a baseline dietary exposure analysis. The baseline assessment for the Insignificant Contributors analysis used the same residue and consumption data from the August 2005 preliminary NMC cumulative risk assessment ( except that 2004 PDP data were also included), and it also included similar assumptions about processing factors, zero residues, and crop translations. 3 EPA used pesticide residues reported in PDP from 1994 2004 ( registered or not) from all ten NMC pesticides for this Insignificant Contributors analysis. The PDP residue data were further extended ( translated) to other commodities identified as reasonable for translation of pesticide residue data per Agency policy. 4 Residues from fish and eggs were not included in this assessment and, based on examination of FDA monitoring results, are not anticipated to contribute significantly to risk associated with the NMC pesticides. However, recent PDP data on beef, pork, and poultry were included in the assessment. Together, the food commodities in the PDP program and those commodities to which the residues are translated account for greater than 90% 95% of children's diets. Exposure for children 1 2 years of age was earlier identified as of specific interest since this was the subgroup with the highest exposure in the preliminary NMC cumulative risk assessment. Dietary ( food only) exposure was estimated using the Dietary Exposure Evaluation Model ( DEEMTM) software which incorporates the 1994 96/ 1998 USDA continuing Surveys for Food Intake by Individuals ( CSFII) data and EPA's Revised Food 3 The key differences between the food files used in the August 2005 preliminary NMC cumulative risk assessment and those used in the Insignificant Contributors analysis are: ( 1) PDP residues were updated to include the most recent PDP data ( through 2004) including additional data on methomyl on strawberries; ( 2) processing factors were updated to account for new food forms that appeared in the new PDP data; and ( 3) aldicarb data on potatoes was modified by deleting the pre 1996 aldicarb data on potatoes. The deletion of pre 1996 aldicarb data is appropriate because the use of aldicarb on potatoes was voluntarily suspended in 1990. The use was reinstated in 1995. Accordingly, PDP data beginning in 1996 is most appropriate to reflect current aldicarb use on potatoes. 4 OPP/ HED SOP 99.3. Memorandum from Margaret Stasikowski, Health Effects Division to Staff. " Translation of Monitoring Data." HED Standard Operating Procedure 99.3 ( 3/ 26/ 99), USEPA. Draft, Internal, Deliberative.

Page 4 of 20 Commodity Intake Database ( Revised FCID). For more information, please refer to Chapter I. C and the associated appendices and datasets in the preliminary NMC cumulative risk assessment.

As described in more detail in the preliminary NMC cumulative assessment, EPA adjusted the amount of residue of each chemical by multiplying by an RPF to obtain the equivalent residue of an index chemical and summed these within each sample. The new calculated residue is termed the Index Equivalent Residue ( ResidueIE) and the exposure value resulting from combining ResidueIE and consumption is termed the Index Equivalent Exposure ( ExposureIE). EPA calculated Margins of Exposure ( MOEs) by comparing the potency adjusted exposure to the point of departure for the index chemical ( ie, oxamyl).

Figure 1 below provides a graphical description of the major contributors to the baseline cumulative dietary risk when all 10 NMCs are included.

Figure 1. Plot of major contributors to the NMC cumulative risk from food5 Relative Contribution of Crop/ Chemical Pairs to Top 0.2 Percentile of Cumulative Distribution for Children 1 2 0% 5% 10% 15% 20% 25% 30% 35% 40% 45%

Strawberry Potato Grape Peach Nectarine Apple Squash, summer Orange Cucumber Plum Watermelon Methiocarb Carbofuran Oxamyl Formetanate hydrochloride Carbaryl Aldicarb Methomyl 5 Three NMCs are not included in the legend   propoxur, thiodicarb, and pirimicarb. These pesticides were either not detected in the PDP data or were detected at such low concentrations and frequencies that they are not sufficient contributors to appear on the graph. Draft, Internal, Deliberative.

Page 5 of 20 Criteria for Designation as an Insignificant Contributor EPA established several criteria for designating crop/ chemical combinations as Insignificant Contributors.

1. Crop/ chemical combinations that produce an MOE greater than 1000 when considered together are Insignificant Contributor tolerances.

  The Agency selected 1000 as a highly conservative point of comparison, incorporating a 10x for interspecies extrapolation, a 10x for intraspecies extrapolation, and a 10x FQPA safety factor for protection of infants and children. The assignment of a value of 10x for the interspecies extrapolation factor is conservative given that human studies are available to inform the chemical specific interspecies factor for some NMCs. 6 The assignment of a value of 10x for the FQPA safety factor is also conservative given that there are studies available for some NMCs which compare the relative sensitivity in juvenile and adult rats, and which will be used to inform the chemical specific FQPA factors. 7 2. Only tolerances for chemicals with completed IREDs are eligible for designation as Insignificant Contributors.

3. Any pesticide/ crop combination with NO detects in all years of PDP monitoring was considered an Insignificant Contributor.

4. Meat, Milk, Poultry and Egg tolerances for which exposure is deemed negligible were considered Insignificant Contributors.

5. Livestock feedstuffs associated with the meat, milk, poultry, and egg samples with few, small, or no detectable residues were considered Insignificant Contributors.

Procedure for Identifying the Insignificant Contributors As described in section II of this document, there were a total of 320 NMC tolerances that required reassessment because they were in existence on the day that FQPA become law. Ninety two of the NMC tolerances have already been reassessed ( 7 methiocarb tolerances, 80 methomyl tolerances, and 5 thiodicarb tolerances). So, EPA used 228 tolerances as the starting point for the ` Insignificant Contributors' analysis.

6 Human studies for aldicarb, methomyl, and oxamyl were reviewed by the Human Studies Review Board ( HSRB) in April, 2006 and determined to be appropriate for use in the NMC Cumulative Risk Assessment. At the May, 2006 meeting of the HSRB, the board did not support the use of the carbofuran oral human study for informing the inter species factor. 7 Comparative cholinesterase studies in adult and juvenile rats are available for carbofuran, formetanate HCl, methomyl, and oxamyl which evaluate peak and time course brain ChE inhibition. A dose response study with adult and juvenile rats exposed at peak time of effect is available for aldicarb. Draft, Internal, Deliberative.

Page 6 of 20 EPA notes, however, that some methomyl uses appear to be contributors to the cumulative food exposure assessment. Thus, the previously reassessed methomyl tolerances were reintroduced into the analysis and methomyl is included in the cumulative dietary risk analysis described below. Methomyl does in fact contribute to the MOEs provided in Table 1, and the tolerance count is given in two different ways in Table 1, to reflect the status of the methomyl tolerances.

EPA has developed the list of Insignificant Contributor tolerances using the stepwise approach described below.

1. EPA performed a baseline cumulative dietary analysis using all 10 NMCs.

2. EPA removed all tolerances for aldicarb and carbofuran. The IREDs for these two NMCs have not yet been completed as of June 29, 2006, and therefore these tolerances are ineligible for Insignificant Contributor designation.

3. EPA performed a cumulative dietary analysis of the remaining potential Insignificant Contributor crop/ chemical combinations. The results are displayed in Figure 2. The plot provides a rank order of the chemical commodity combinations that contribute to the NMC cumulative food exposure assessment.

4. EPA removed from the analysis, in groups of several tolerances, the crop/ chemical combinations which made the highest contribution to the cumulative risk. The DEEMestimated MOEs that resulted from the sequential removal of each group of tolerances are provided in Table 1. The " removed" crop/ chemical combinations in column 1 of Table 1 are not deemed Insignificant Contributors at this time because they potentially contribute to NMC cumulative risk ( i. e., they are responsible, jointly, for MOEs less than 1000).

5. EPA repeated the removal process described in step 4 until the MOEs at the 99.9th percentile of exposure exceeded 1000 for children age 1 2, the population subgroup determined to have the lowest MOEs. EPA's analysis of risk to this population subgroup is therefore protective of all other population subgroups groups.

6. All remaining crop/ chemical combinations are considered Insignificant Contributors since, when considered together, they contribute only minor amounts to risk, with MOEs of greater than 1000. Draft, Internal, Deliberative.

Page 7 of 20 Figure 2. Plot of major contributors to the NMC cumulative risk from food, excluding aldicarb and carbofuran Exposure at the 99.8th Percentile and Above for Children 1 2 0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45 0.5 Strawberry Grape Peach Nectarine Apple Plum Watermelon Squash, summer Spinach Cucumber Apricot Lettuce Pear Cabbage Cantaloupe Asparagus Squash, winter Brussels sprouts Orange Cherry Celery Honeydew melon Pepper, bell Endive Tomato Methiocarb Thiodicarb Oxamyl Formetanate hydrochloride Carbaryl Methomyl Sum of H X F Food PARENTPESTICIDE IV. Results of the Insignificant Contributors Analysis Table 1 presents a summary of the results of the Insignificant Contributors analysis. The table shows, sequentially, the crop/ chemical combinations that were removed at each step in the process. The table also provides the number of tolerances removed that were associated with the these crop/ chemical combinations, the number of tolerances that remain, the associated MOE, as well as a reference run identification number for the DEEM computer files used to produce these exposure estimates ( the DEEM files are provided on the NMC cumulative web page at www. epa. gov/ pesticides/ cumulative). Page 8 of 20 Table 1. Summary of Insignificant Contributors analysis conducted with DEEM Number of Tolerances Scenario* Number of Crop/ Chemical Combinations Removed NMC tolerances ( excluding those previously assessed) All NMC tolerances MOE Ref.

Run ID Baseline ( all NMCs) 0 228 320 31 1 Remove all aldicarb and carbofuran crop/ chemical combinations 62 166 258 49 2 Remove 12 crop/ chemical combinations   methomyl on strawberry, cucurbits, and grape; carbaryl on strawberry, pome fruit, plum, and peach; formetanate hydrochloride on nectarine, plum ( no tolerance), and peach; and oxamyl on summer squash and cucumber. 12 158 247 154 3 Remove 7 crop/ chemical combinations   carbaryl on grape; formetanate hydrochloride on apple; methomyl on spinach, lettuce, cabbage, and peach; oxamyl on apple 7 155 240 348 4 Remove 6 crop/ chemical combinations   formetanate hydrochloride on pear; carbaryl on apricot and beans;

and oxamyl on celery and watermelon; methomyl on plum ( no tolerance) 6 150 235 519 5 Remove 6 crop/ chemical combinations   formetanate hydrochloride on apricot ( no tolerance); carbaryl on citrus fruit and peppers; oxamyl on bell pepper;

methomyl on apple and succulent beans 6 147 230 783 6 Remove 5 crop/ chemical combinations   carbaryl on nectarine and cherry; oxamyl on pear; methomyl on orange and tomato 5 144 225 1224 7 * Italicized crop/ chemical combinations are ones for which there are no tolerances, or for which tolerances were previously reassessed ( i. e., methomyl). Page 9 of 20 A total of 144 of the 228 NMC tolerances that remain to be reassessed meet EPA's criteria for designation as Insignificant Contributors due to no exposure or low exposure. A total of 84 tolerances do not meet the Agency's criteria for designation as Insignificant Contributors, either because they are aldicarb or carbofuran tolerances, or because their inclusion in the analysis results in MOEs of less than 1000. Please see Table 2, below, for a summary of the tolerance breakdown. ( A listing of the 144 tolerances being reassessed at this time appears in Table A. 1. A listing of the 84 tolerances not meeting the Insignificant Contributors criteria appears in Tables A. 4 and A. 5.) EPA may require mitigation for some of the uses associated with the 84 tolerances not meeting the Insignificant Contributors criteria, in connection with its completion of the outstanding IREDS and release of the revised NMC cumulative risk assessment.

Sixty nine of the 80 previously reassessed methomyl tolerances meet EPA's criteria for designation as ` Insignificant Contributors' due to no exposure or low exposure. ( A listing of these 69 tolerances appears in Table A. 2.) However, eleven methomyl tolerances do not meet the ` Insignificant Contributors' criteria because the Agency needed to remove them from the analysis in order to reach MOEs of greater than 1000. ( A listing of these 11 tolerances appears in Table A. 3.) Notwithstanding the fact that the methomyl tolerances were reassessed in connection with the 1998 methomyl RED, the Agency may require additional mitigation for some of the methomyl uses associated with the eleven methomyl tolerances that do not meet the ` Insignificant Contributors' criteria. The Agency will make its decision about the necessity of mitigation in conjunction with its completion of the final NMC cumulative risk assessment.

The Agency notes that this is a screening level assessment designed to ensure that risk is not underestimated. By selecting a point of comparison value of 1000, the Agency has produced a conservative assessment that assumes that the interspecies, intraspecies, and FQPA factors will be assigned values of 10. These values are conservative because the Agency anticipates that the interspecies and/ or FQPA safety factors for some of the NMCs will be assigned lower values in the revised NMC cumulative assessment, based on recently submitted data.

Following the completion of the revised NMC cumulative risk assessment, more tolerances are expected to be eligible for reassessment. However, for purposes of this screening level analysis, the Agency has elected to assign maximum safety factor values to ensure that risk is not underestimated. Draft, Internal, Deliberative.

Page 10 of 20 Table 2. Summary of tolerances designated as ` Insignificant Contributors' compared with tolerances excluded from the assessment Insignificant Contributors Tolerances Excluded from the Assessment 144 tolerances   11 tolerances: Crop/ chemical combinations with NO detects in all years of PDP monitoring [ listed in Table A. 1 as " ND"]

  27 tolerances: Meat, milk, poultry and egg tolerances for which exposure is deemed negligible [ listed in Table A. 1 as " M"]

  32 tolerances: Livestock feed stuffs associated with the meat, milk, poultry, and egg samples for which few, small, or no detectable residues were found [ listed in Table A. 1 as " FS"]

  74 tolerances: Low contributors a to cumulative risk ( i. e., MOEs of greater than 1000 when considered together ) [ listed in Table A. 1 as " LC"] 84 Tolerances   62 tolerances not eligible ( aldicarb and carbofuran)

52 low contributorsa 10 high contributors 62 TOTAL 23 aldicarb 39 carbofuran 62 TOTAL [ Listed in Table A. 5]

  22 tolerances not eligible ( high contributors)

[ Listed in Table A. 4] 11 carbaryl 4 formetanate HCl 7 oxamyl 22 TOTAL a Low contributors are those tolerances that produce MOEs of > 1000 when the high contributors are not included in the analysis.

V. Conclusions EPA has concluded that the 144 tolerances identified in this document as Insignificant Contributors to the NMC cumulative risk meet the safety standard of section 408( b)( 2) of the FFDCA, and may therefore be considered reassessed, pursuant to section 408( q) as of today's date, June 29, 2006.

As a result of this decision, there are 84 NMC tolerances that remain to be reassessed. These remaining 84 tolerances will be reassessed when EPA completes the IREDs for aldicarb and carbofuran and issues the final NMC cumulative risk assessment. Draft, Internal, Deliberative.

Page 11 of 20 APPENDIX Table A. 1 Insignificant Contributor Tolerances due to no exposure or low exposure Pesticide Name Commodity Name Reason For Insignificant Contributor Status1 Carbaryl Alfalfa FS Carbaryl Alfalfa, Hay FS Carbaryl Almonds LC Carbaryl Almonds, Hulls FS Carbaryl Asparagus LC Carbaryl Bananas ND Carbaryl Beets, Garden, Roots LC Carbaryl Beets, Garden, Tops FS Carbaryl Beets, Sugar LC Carbaryl Blackberries LC Carbaryl Blueberries LC Carbaryl Boysenberries LC Carbaryl Broccoli LC Carbaryl Brussels Sprouts LC Carbaryl Cabbage LC Carbaryl Cabbage, Chinese LC Carbaryl Carrots LC Carbaryl Cattle, Fat M Carbaryl Cattle, Kidney M Carbaryl Cattle, Liver M Carbaryl Cattle, Meat By Products ( excluding kidney & liver) M Carbaryl Cattle, Meat M Carbaryl Cauliflower ND Carbaryl Celery LC Carbaryl Chestnuts LC Carbaryl Clover FS Carbaryl Clover, Hay FS Carbaryl Collards LC Carbaryl Corn ( including sweet) ( kernel + cobs w/ husks removed) ND Carbaryl Corn, Fodder FS Carbaryl Corn, Forage FS Carbaryl Cotton, Seed FS Carbaryl Cranberries LC Carbaryl Cucumbers LC Carbaryl Dandelions LC Carbaryl Dewberries LC Carbaryl Dill LC Carbaryl Eggplant LC Carbaryl Endive ( Escarole) LC Carbaryl Filberts ( Hazelnuts) LC Carbaryl Flax, Seed LC Carbaryl Goats, Fat M Draft, Internal, Deliberative.

Page 12 of 20 Table A. 1 Insignificant Contributor Tolerances due to no exposure or low exposure Pesticide Name Commodity Name Reason For Insignificant Contributor Status1 Carbaryl Goats, Kidney M Carbaryl Goats, Liver M Carbaryl Goats, Meat By Products ( excluding kidney & liver) M Carbaryl Goats, Meat M Carbaryl Grasses FS Carbaryl Grasses, Hay FS Carbaryl Hogs, Fat M Carbaryl Hogs, Kidney M Carbaryl Hogs, Liver M Carbaryl Hogs, Meat By Products M Carbaryl Hogs, Meat M Carbaryl Horseradish LC Carbaryl Horses, Fat M Carbaryl Horses, Kidney M Carbaryl Horses, Liver M Carbaryl Horses, Meat By Products ( excluding kidney & liver) M Carbaryl Horses, Meat M Carbaryl Kale LC Carbaryl Kohlrabi LC Carbaryl Lentils ND Carbaryl Lettuce LC Carbaryl Loganberries LC Carbary Melons LC Carbaryl Milk M Carbaryl Millet, Proso, Grain FS Carbaryl Millet, Proso, Straw FS Carbaryl Mustard, Greens LC Carbaryl Okra LC Carbaryl Olives LC Carbaryl Oysters M Carbaryl Parsley LC Carbaryl Parsnips LC Carbaryl Peanuts LC Carbaryl Peanuts, Hay FS Carbaryl Peas, Cowpeas LC Carbaryl Peas, Cowpeas, Forage FS Carbaryl Peas, Cowpeas, Hay FS Carbaryl Peas, Vines FS Carbaryl Peas, with Pods LC Carbaryl Pecans LC Carbaryl Pineapples LC Carbaryl Pistachios LC Carbaryl Potatoes ND Carbaryl Prickly Pear Cactus, Fruit LC Carbaryl Prickly Pear Cactus, Pads LC Draft, Internal, Deliberative.

Page 13 of 20 Table A. 1 Insignificant Contributor Tolerances due to no exposure or low exposure Pesticide Name Commodity Name Reason For Insignificant Contributor Status1 Carbaryl Pumpkins LC Carbaryl Radishes LC Carbaryl Raspberries LC Carbaryl Rice LC Carbaryl Rice, Straw FS Carbaryl Rutabagas LC Carbaryl Salsify, Roots LC Carbaryl Salsify, Tops LC Carbaryl Sheep, Fat M Carbaryl Sheep, Kidney M Carbaryl Sheep, Liver M Carbaryl Sheep, Meat By Products ( kidney & liver) M Carbaryl Sheep, Meat M Carbaryl Sorghum, Forage FS Carbaryl Sorghum, Grain FS Carbaryl Soybeans ND Carbaryl Soybeans, Forage FS Carbaryl Soybeans, Hay FS Carbaryl Spinach LC Carbaryl Squash, Summer LC Carbaryl Squash, Winter LC Carbaryl Sunflower, Seeds LC Carbaryl Sweet Potatoes LC Carbaryl Swiss Chard LC Carbaryl Tomatoes LC Carbaryl Trefoil, Birdsfoot, Forage FS Carbaryl Trefoil, Birdsfoot, Hay FS Carbaryl Turnips, Roots LC Carbaryl Turnips, Tops FS Carbaryl Walnuts LC Carbaryl Wheat, Fodder, Green FS Carbaryl Wheat, Grain FS Carbaryl Wheat, Straw FS Formetanate HCl Grapefruit LC Formetanate HCl Lemons LC Formetanate HCl Limes LC Formetanate HCl Oranges LC Formetanate HCl Tangerines LC Oxamyl Bananas ND Oxamyl Cantaloupes LC Oxamyl Citrus Fruits LC Oxamyl Cotton, Seed LC Oxamyl Eggplant LC Oxamyl Honeydew LC Oxamyl Peanuts LC Draft, Internal, Deliberative.

Page 14 of 20 Table A. 1 Insignificant Contributor Tolerances due to no exposure or low exposure Pesticide Name Commodity Name Reason For Insignificant Contributor Status1 Oxamyl Peanuts, Hay FS Oxamyl Peppermint, Hay FS Oxamyl Peppers, Non Bell LC Oxamyl Pineapples ND Oxamyl Pineapples, Bran FS Oxamyl Potatoes ND Oxamyl Pumpkins LC Oxamyl Soybeans ND Oxamyl Spearmint, Hay FS Oxamyl Squash, Winter LC Oxamyl Tomatoes LC Oxamyl Vegetables, Root Crop ND 1 FS = Feed Stuff; LC = Low Contribution; M = Meat, Milk, Poultry, Eggs; ND = No detects in PDP.

Table A. 2 Previously reassessed methomyl tolerances which are ` Insignificant Contributors' due to no exposure or low exposure Pesticide Name Commodity Name Methomyl Alfalfa Methomyl Asparagus Methomyl Avocados Methomyl Barley, grain Methomyl Barley, hay Methomyl Barley, straw Methomyl Beans, dry Methomyl Beets, Tops Methomyl Blueberries Methomyl Broccoli Methomyl Brussels Sprouts Methomyl Cabbage, Chinese Methomyl Cauliflower Methomyl Celery Methomyl Collards Methomyl Corn, Fodder Methomyl Corn, Forage Methomyl Corn, fresh ( inc sweet, kernel plus cob with husks removed)

Methomyl Corn, grain ( inc pop)

Methomyl Cotton, seed Methomyl Dandelions Methomyl Endive ( Escarole)

Methomyl Grapefruit Methomyl Grasses, Bermuda Methomyl Grasses, Bermuda, hay ( dry, dehydrated)

Methomyl Kale Methomyl Leeks Methomyl Lemons Draft, Internal, Deliberative.

Page 15 of 20 Table A. 2 Previously reassessed methomyl tolerances which are ` Insignificant Contributors' due to no exposure or low exposure Pesticide Name Commodity Name Methomyl Lentils Methomyl Mint, hay Methomyl Mustard, greens Methomyl Nectarines Methomyl Oats, forage Methomyl Oats, grain Methomyl Oats, hay Methomyl Oats, straw Methomyl Onions, green Methomyl Parsley Methomyl Peanuts Methomyl Pears Methomyl Peas Methomyl Peas, vines Methomyl Pecans Methomyl Peppers Methomyl Pomegranates Methomyl Rye, forage Methomyl Rye, grain Methomyl Rye, straw Methomyl Sorghum, forage Methomyl Sorghum, grain Methomyl Soybeans Methomyl Soybeans, forage Methomyl Swiss chard Methomyl Tangerines Methomyl Turnips, greens, tops Methomyl Vegetables, brassica, leafy, group 5 Methomyl Vegetables, fruiting Methomyl Vegetables, leafy Methomyl Wheat, forage Methomyl Wheat, grain Methomyl Wheat, hay Methomyl Wheat, straw Table A. 3 Previously reassessed methomyl tolerances which are not ` Insignificant Contributors' due to high contribution to exposure Pesticide Name Commodity Name Methomyl Apple Methomyl Beans, succulent Methomyl Cabbage Methomyl Cucurbits Methomyl Grapes Methomyl Lettuce Draft, Internal, Deliberative.

Page 16 of 20 Table A. 3 Previously reassessed methomyl tolerances which are not ` Insignificant Contributors' due to high contribution to exposure Pesticide Name Commodity Name Methomyl Oranges Methomyl Peaches Methomyl Spinach Methomyl Strawberries Methomyl Tomatoes Table A. 4 Tolerances which require reassessment that are not ` Insignificant Contributors' due to high contribution to exposure Pesticide Name Commodity Name Carbaryl Apricots Carbaryl Beans Carbaryl Cherries Carbaryl Citrus Fruits Carbaryl Fruits, Pome Carbaryl Grapes Carbaryl Nectarines Carbaryl Peaches Carbaryl Peppers Carbaryl Plums ( fresh prunes)

Carbaryl Strawberries Formetanate HCl Apples Formetanate HCl Nectarines Formetanate HCl Peaches Formetanate HCl Pears Oxamyl Apples Oxamyl Celery Oxamyl Cucumbers Oxamyl Pears Oxamyl Peppers, Bell Oxamyl Squash, Summer Oxamyl Watermelons Table A. 5 Tolerances which require reassessment that are not ` Insignificant Contributors' because the associated IREDs have not been completed Pesticide Name High Contributor versus Low Contributor Commodity Name Aldicarb High Grapefruit Aldicarb High Oranges Aldicarb High Potatoes Aldicarb High Sweet Potatoes Aldicarb Low Beans, Dry Aldicarb Low Beets, Sugar Aldicarb Low Beets, Sugar, Tops Draft, Internal, Deliberative.

Page 17 of 20 Table A. 5 Tolerances which require reassessment that are not ` Insignificant Contributors' because the associated IREDs have not been completed Pesticide Name High Contributor versus Low Contributor Commodity Name Aldicarb Low Citrus, Dried Pulp Aldicarb Low Coffee Beans Aldicarb Low Cotton, Seed Aldicarb Low Cotton, Seed, Hulls Aldicarb Low Lemons Aldicarb Low Limes Aldicarb Low Peanuts Aldicarb Low Pecans Aldicarb Low Sorghum, Grain Aldicarb Low Sorghum, Bran Aldicarb Low Sorghum, Bran Aldicarb Low Sorghum, Grain, Fodder Aldicarb Low Soybeans Aldicarb Low Sugarcane Aldicarb Low Sugarcane, Fodder Aldicarb Low Sugarcane, Forage Carbofuran High Cucumbers Carbofuran High Grapes Carbofuran High Melons Carbofuran High Potatoes Carbofuran High Raisins Carbofuran High Squash Carbofuran Low Alfalfa, Fresh Carbofuran Low Alfalfa, Hay Carbofuran Low Artichokes Carbofuran Low Bananas Carbofuran Low Barley, Grain Carbofuran Low Barley, Straw Carbofuran Low Beets, Sugar Carbofuran Low Beets, Sugar, Tops Carbofuran Low Coffee Beans Carbofuran Low Corn, Fodder Carbofuran Low Corn, Forage Carbofuran Low Corn, Fresh ( inc. sweet) ( kernel + cob w/ husks removed)

Carbofuran Low Corn, Grain ( including popcorn)

Carbofuran Low Cotton, Seed Carbofuran Low Cranberries Carbofuran Low Milk Carbofuran Low Oats, Grain Carbofuran Low Oats, Straw Carbofuran Low Peppers Carbofuran Low Pumpkins Carbofuran Low Rice Carbofuran Low Rice, Straw Carbofuran Low Sorghum, Fodder Draft, Internal, Deliberative.

Page 18 of 20 Table A. 5 Tolerances which require reassessment that are not ` Insignificant Contributors' because the associated IREDs have not been completed Pesticide Name High Contributor versus Low Contributor Commodity Name Carbofuran Low Sorghum, Forage Carbofuran Low Sorghum, Grain Carbofuran Low Soybeans Carbofuran Low Soybeans, Forage Carbofuran Low Soybeans, Hay Carbofuran Low Strawberries Carbofuran Low Sugarcane Carbofuran Low Sunflower, Seeds Carbofuran Low Wheat, Grain Carbofuran Low Wheat, Straw Table A. 6 Tolerances that have already been reassessed Pesticide Name Commodity Name Methiocarb Citrus Fruits Methiocarb Corn, field, grains Methiocarb Corn, fodder Methiocarb Corn, forage Methiocarb Corn ( including sweet) ( kernel + cobs w/ husks removed) Methiocarb Corn, grain ( including popcorn) Methiocarb Peaches Methomyl Alfalfa Methomyl Apples Methomyl Asparagus Methomyl Avocados Methomyl Barley, grain Methomyl Barley, hay Methomyl Barley, straw Methomyl Beans, dry Methomyl Beans, succulent Methomyl Beets, tops Methomyl Blueberries Methomyl Brassica ( Cole) Leafy Vegetables Methomyl Broccoli Methomyl Brussels sprouts Methomyl Cabbage Methomyl Cabbage, Chinese Methomyl Cauliflower Methomyl Celery Methomyl Collards Methomyl Corn, fodder Methomyl Corn, forage Methomyl Corn ( including sweet) ( kernel + cobs w/ husks removed) Methomyl Corn, Grain ( including popcorn) Methomyl Cotton, seed Methomyl Cucurbits Methomyl Dandelions Methomyl Endive ( escarole) Methomyl Grapefruit Methomyl Grapes Draft, Internal, Deliberative.

Page 19 of 20 Table A. 6 Tolerances that have already been reassessed Pesticide Name Commodity Name Methomyl Grasses, bermuda Methomyl Grasses, bermuda, hay ( dry, dehydrated) Methomyl Kale Methomyl Leeks Methomyl Lemons Methomyl Lentils Methomyl Lettuce Methomyl Mint, hay Methomyl Mustard, greens Methomyl Nectarines Methomyl Oats, forage Methomyl Oats, grain Methomyl Oats, hay Methomyl Oats, straw Methomyl Onions, green Methomyl Oranges Methomyl Parsley Methomyl Peaches Methomyl Peanuts Methomyl Pears Methomyl Peas Methomyl Peas, vines Methomyl Pecans Methomyl Peppers Methomyl Pomegranates Methomyl Rye, forage Methomyl Rye, grain Methomyl Rye, straw Methomyl Sorghum, forage Methomyl Sorghum, grain Methomyl Soybeans Methomyl Soybeans, forage Methomyl Spinach Methomyl Strawberries Methomyl Swiss Chard Methomyl Tangerines Methomyl Tomatoes Methomyl Turnips, greens, tops Methomyl Vegetables, fruiting Methomyl Vegetables, leafy Methomyl Wheat, forage Methomyl Wheat, grain Methomyl Wheat, hay Methomyl Wheat, straw Methomyl Barley, Forage Methomyl Beans, Forage Methomyl Hops, Dried Methomyl Peanuts, Hulls Methomyl Rye, Hay Methomyl Vegetables, Root Crop Methomyl Watercress Thiodicarb Corn ( including sweet) ( kernel + cobs w/ husks removed) Thiodicarb Cotton, seed Thiodicarb Soybeans Thiodicarb Soybeans, hulls Draft, Internal, Deliberative.

Page 20 of 20 Table A. 6 Tolerances that have already been reassessed Pesticide Name Commodity Name Thiodicarb Cotton, seed, hulls