UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

Office of Chemical Safety and Pollution Prevention

MEMORANDUM

Date:		26-October-2011

Subject:	Difenoconazole.  Acute and Chronic Aggregate Dietary Exposure and Risk Assessments for the Amended Section 3 Registration to Add Seed Treatment Uses on Oats and Rye.

PC Code:  	128847	DP Barcode:	389652

Decision No.: 440121	Registration No.:  None

Petition Nos.:  0F7785	Regulatory Action:  Amended Section 3

Assessment Type:  Single Chemical, Dietary 	Registration Case No.:  NA

TXR No.:  None	CAS No.:  119446-68-3

MRID No.:  None	40 CFR: 180.475

Reviewer:	Thurston G. Morton, Chemist

Risk Assessment Branch IV/Health Effects Division (RABIV/HED; 7509P)

Through:	Dennis McNeilly Chemist

David Hrdy, Senior Scientist

Dietary Exposure Science Advisory Council (DESAC)

	And

Susan V. Hummel, Senior Chemist

RABIV/HED (7509P)

To:			Rebecca Daiss, Risk Assessor

RABIV/HED (7509P)

	And

			Elissa Reaves, Branch Chief

RABIV/HED (7509P)

	And

Tony Kish

Fungicide Branch/RD (7505P)

Executive Summary

Aggregate (food + water) acute and chronic dietary risk assessments were conducted using the Dietary Exposure Evaluation Model - Food Consumption Intake Database (DEEM-FCID(, ver. 2.03).  This model uses food consumption data from the United States Department of Agriculture’s (USDA’s) Continuing Surveys of Food Intakes by Individuals (CSFII; 1994-1996 and 1998).  The analyses were performed to support an amended Section 3 registration to add seed treatment uses on oats and rye of the fungicide difenoconazole [1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-ylmet hyl]-1H-1,2,4-triazole].

μg/L (ppb) was used for the acute dietary exposure analysis and an EDWC of 10.4 μg/L (ppb) was used for the chronic dietary exposure analysis.

The resulting acute food plus water exposure estimates were less than HED’s level of concern (<100% of the acute population-adjusted dose (aPAD)) at the 95th percentile of the exposure distribution for the general U.S. population (8 % aPAD) and all population sub-groups; the most highly exposed population subgroup was children1 - 2 years old with 19 % aPAD.  The somewhat refined chronic analysis assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, the available empirical or DEEM( (ver. 7.81) default processing factors, and 100 % CT.  The resulting chronic food plus water exposure estimates were less than HED’s level of concern (<100% of the chronic population-adjusted dose (cPAD)) for the general U.S. population (18 % cPAD) and all population sub-groups; the most highly exposed population subgroup was children 1 - 2 years old with 46 % cPAD.

The requested amended uses of difenoconazole did not result in an increase in dietary exposure estimates for free triazole or conjugated triazoles.  Therefore, the last dietary exposure analyses for the triazole metabolites (D388469, T. Morton, 27 Apr. 2011) will not need to be updated and still applies.

I.   Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the PAD.  The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  HED is generally concerned when estimated cancer risk exceeds one in one million.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link:      HYPERLINK "http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf"  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for difenoconazole was conducted by T. Morton (3-March-2011; DP#378938).

II.   Residue Information

Difenoconazole tolerances are published in 40 CFR§180.475.

Residues of Concern in Plants and Livestock:   The HED Metabolism Assessment Review Committee (MARC) has determined that for tolerance expression and risk assessment purposes, the residue of concern is difenoconazole per se for plant and livestock commodities.  The MARC, however, stated that if tolerances are proposed for difenoconazole resulting from foliar uses which result in higher residue levels of CGA-205375 than parent, then the need to include CGA-205375 should be reconsidered (Memo, G. Kramer, 22-JUL-1994; No DP#).  Because the petitioner has now proposed foliar uses of difenoconazole, which result in higher residues in crop commodities, the need to include metabolite CGA 205375 in the tolerance expression and/or risk assessment has been re-examined.  Based upon a review of the previously-submitted metabolism data for difenoconazole, HED concludes the residue of concern for both tolerance setting and risk assessment for the crops included in this petition is difenoconazole.  However, HED concludes the residue of concern in livestock for tolerance setting and risk assessment are difenoconazole and its metabolite CGA 205375 (for more details, see the summary document, DP# 340379).  Table 1 below summarizes tolerance expression and the residues of concern in plant and livestock commodities.

Table 1.  Difenoconazole Residues of Concern in Plants and Ruminants.

Matrix

Residues of Concern

For Risk Assessment

For Tolerance Expression

Plants	Primary and Rotational crops

Parent Only

Parent Only

Livestock	Ruminant and Poultry

Parent and CGA 205375

Parent and CGA 205375

Drinking Water

Parent Only

NA

No new residue data was submitted to support an amended Section 3 registration to add seed treatment uses on oats and rye.  These amended uses are covered by previously submitted residue data.  The amended uses of difenoconazole do not increase the livestock dietary burden and does not affect the livestock tolerances.

Previously Recommended Tolerances:  Based on the residue chemistry data submitted with the previous petitions, HED recommended for establishment of the new food tolerances (DP# 366507, B. Cropp-Kohlligian, 23-Feb-2011).  The newly recommended, established, and revised tolerances are listed in Table 2 below.

Table 2.  Tolerance Summary for Difenoconazole (non feed items).

Commodity	Existing/Established Tolerances (ppm)	New Tolerances (ppm)

Almond, nutmeat	0.03	------

Brassica subgroup 5A	1.9	------

Brassica subgroup 5B	35	------

Citrus oil	25	------

Fruit, citrus, group 10	0.6	------

Grape	4.0	------

Grape, raisin	6.0	------

Nut, tree, group 14	0.03	------

Onion, bulb, subgroup 3—07A	0.20	------

Onion, green, subgroup 3—07B	6.0	------

Pistachios	0.03	------

Vegetable, cucurbit, group 9	0.7	------

Fruit, Pome, group 11	1.0	------

Vegetable, Fruiting, Group 8	0.60	------

Vegetable, Tuberous and Corm, subgroup 1C	0.01	------

Beet, sugar	0.30	------

Papaya	0.30	------

Banana	0.2	------

Barley, grain	0.1	0.10

Canola, seed	0.01	------

Cattle fat	0.10	------

Cattle, meat	0.05	------

Cattle, meat byproducts	0.10	------

Cattle, liver	0.40	------

Corn, sweet, kernel plus cob with husks removed	0.01	------

Cotton, undelinted seed	0.05	------

Egg	0.02	------

Goat, fat	0.10	------

Goat, meat	0.05	------

Goat, meat byproducts (except liver)	0.10	------

Goat, liver	0.40	------

Hog, fat	0.10	------

Hog, meat	0.05	------

Hog, meat byproducts (except liver)	0.1	------

Hog, liver	0.40	------

Horse, fat	0.10	------

Horse, meat	0.05	------

Horse, meat byproducts (except liver)	0.10	------

Horse, liver	0.40	------

Milk	0.01	------

Rye, grain	0.1	0.01

Sheep, fat	0.10	------

Sheep, meat	0.05	------

Sheep, meat byproducts (except liver)	0.10	------

Sheep, liver	0.40	------

Wheat, grain	0.1	0.10

Wax apple	0.07	------

Mango	0.07	------

Carrot	------	0.50

Chickpea	------	0.08

Soybean, seed	------	0.15

Fruit, stone, group 12	------	2.5

Strawberry	------	2.5

Turnip greens	------	35

Oat, grain	------	0.01

The requested amended uses of difenoconazole did not result in an increase in dietary exposure estimates for free triazole or conjugated triazoles.  Therefore, the last dietary exposure analyses for the triazole metabolites (D388469, T. Morton, 27 Apr. 2011) will not need to be updated.

Food Residues and processing factors used in the Acute and Chronic Analysis:  The acute analysis assumed tolerance-level residues, maximum expected residues for wheat grain and barley grain from field trials with a lower method LOQ, and 100% CT for all the registered and proposed crops.  Tolerance-level residues were also assumed for all livestock tissues in this assessment.  The chronic analysis assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, and 100 % CT.  Those commodities where field trial data were used are summarized below.  HED SOP 2000.1 Guidance for Translation of Field Trial Data from Representative Commodities in the Crop Group Regulation to Other Commodities in Each Crop Group/Subgroup dated 9/12/2000 was used in translating to other commodities in the crop group.  Experimental processing factors were used for apple juice (0.04x), grape juice (0.2x), citrus juices (0.1x), potato chips (0.5x), potato granules/flakes (0.5x), raisin (3.5x chronic only since raisin tolerance used in acute), sugar beet molasses (0.6x), tomato paste (1.6x), and tomato puree (0.5x); DEEM( (ver. 7.81) default processing factors were assumed for other processed commodities.

Almond: Field trial residues were used from MRID 47586101.

Apple: Field trial residues were used from MRID 46950233.

Broccoli: Field trial residues were used from MRID 47586102.  Residues from 1-7 day PHI were used since registered labels allow from 1-7 day PHIs.

Cabbage:  Field trial residues were used from 47586102.  Residues from 1-7 day PHI were used since registered labels allow from 1-7 day PHIs.  To refine the dietary exposure data from only cabbage samples without wrapper leaves were used.

Cantaloupe: Field trial residues were used from MRID 47586103.  Residues from 0-1 day PHI were used since registered labels allow from 0-1 day PHI.

Carrot: Field trial residues were used from MRID 47929804.

Chickpea: Field trial residues were used from MRID 47929805.

Cucumber: Field trial residues were used from MRID 47586103.  Residues from 0-1 day PHI were used since registered labels allow from 0-1 day PHI.

Grape: Field trial residues were used from MRID 47586105.

Grapefruit: Field trial residues were used from MRID 47586104.

Lemon: Field trial residues were used from MRID 47586104.

Lime: Field trial residues were used from MRID 47586104.

Mustard Greens: Field trial residues were used from MRIDs 47417704, 47417707, and 47586102.  Residues from 1-7 day PHI were used since registered labels allow from 1-7 day PHIs.

Orange: Field trial residues were used from MRID 47586104.

Pear: Field trial residues were used from MRID 46950233.

Pecan: Field trial residues were used from MRID 47586106.

Peppers: Field trial residues were used from MRID 46950234.

Potato: Field trial residues were used from MRID 46950235.

Soybean: Field trial residues were used from MRID 47929801.

Stone Fruit: Field trial residues were used from MRID 47929803.

Strawberry: Field trial residues were used from MRID 47929802.

Sugar Beet: Field trial residues were used from MRID 46950236.

Summer Squash: Field trial residues were used from MRID 47586103.  Residues from 0-1 day PHI were used since registered labels allow from 0-1 day PHIs.

Tomato: Field trial residues were used from MRIDs 46950234, 47417705, and 47417708.

  Drinking Water Data

The drinking water estimates used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED; Memo, I. Maher, 1-June-2010; D371044).  EFED conducted a Tier II drinking water assessment for surface water sources using the Pesticide Root Zone/Exposure Analysis Modeling System (PRZM/EXAMS) for the registered and proposed new uses.  Among all the registered and proposed new uses, the highest estimated drinking water concentrations (EDWCs) for surface water sources were derived for aerial applications of difenoconazole to New York grapes at the maximum annual application rate of 0.46 lb ai/acre. The estimated drinking water residues for 1-in-10 year annual peak, 1-in-10 year annual mean, and 36-year annual mean are 15.8, 10.4, and 7.62 μg/L (ppb) respectively.

The highest SCI-GROW estimated drinking water concentration of difenoconazole from shallow ground water sources is 1.28 x 10-2 µg/L, obtained for the maximum application rate for ornamentals (0.52 lb ai/A; D333319).  These concentrations can be considered as both the acute and chronic groundwater values.  The EDWCs from ground water sources are expected to be the same for the proposed golf course turf uses as estimated for ornamentals.

μg/L (ppb)  was used for the acute dietary (food plus water) exposure analysis and the 1-in-10 year annual mean EDWC of 10.4 μg/L (ppb) was used for the chronic dietary (food plus water) exposure analysis.

IV.   DEEM-FCID( Program and Consumption Information

Difenoconazole acute and chronic dietary exposure assessments were conducted using the DEEM-FCID( (ver. 2.03), which incorporates consumption data from USDA’s CSFII (1994-1996 and 1998).  The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups:  the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form.  The resulting residue consumption estimate for each food/food form is summed with the residue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, for Tiers 1 and 2, significant differences in user vs. per capita exposure and risk are identified and noted in the risk assessment.

V.   Toxicological Information

On 08-SEP-1998, HED’s Hazard Identification Assessment Review Committee (HIARC) evaluated the toxicology database of difenoconazole and re-assessed the RfD established in 1994, as well as the toxicological endpoints for the dietary and occupational exposure risk assessments that were selected in 1994.  At this meeting, the HIARC also addressed the potential enhanced sensitivity of infants and children from exposure to difenoconazole as required by the Food Quality Protection Act (FQPA) of 1996 (HED Doc. No. 012873, 25-SEP-1998).  In July, 2007, the RAB1 toxicologists and risk assessment team met to reevaluate the endpoints selected by the HIARC since new studies were submitted.  RAB1 toxicologists and risk assessment team also reevaluated FQPA assessments.  The risk assessment team concluded that the default 10x FQPA Safety Factor (SF) should be reduced to 1x when assessing acute and chronic dietary exposures (M.Sahafeyan, D333320, 09-AUG-07).  The relevant endpoints are shown in Table 3.

In accordance with HED’s current policy and EPA’s 2005 Cancer Guidelines, difenoconazole is classified as “Suggestive Evidence of Carcinogenic Potential,” based on excessive toxicity observed at the two highest doses, the absence of tumors at the lower doses and the absence of genotoxic effects.   A margin-of-exposure (MOE) approach in risk assessment was advocated by HED’s  CPRC in 1994.  Use of an MOE approach was reviewed and reaffirmed in 2007 by the CPRC Chair (PV Shah, 3/1/07, HED Doc. No. 0054532).

Therefore, a separate cancer dietary assessment is not being conducted for difenoconazole.

Table 3.  Summary of Toxicological Doses and Endpoints for Difenoconazole for Use in Dietary Risk Assessments.

Exposure Scenario	Point of Departure	Uncertainty/FQPA Safety Factors RfD, PAD, for Risk Assessment	Study and Relevant Toxicological Effects

Acute Dietary (All populations)	NOAEL = 25

mg/kg	UFA = 10X

UFH = 10X

FQPA SF = 1X 	aRfD = aPAD = 0.25 mg/kg/day	Acute Neurotoxicity Study in Rats

LOAEL= 200 mg/kg in males based on reduced fore-limb grip strength in males on day 1.

Chronic Dietary (All populations)	NOAEL = 0.96

mg/kg/day	UFA = 10X

UFH = 10X

FQPA SF = 1X	cRfD = cPAD = 0.01mg/kg/day	Combined chronic toxicity/carcinogenicity (rat; dietary) LOAEL = 24.1/32.8 mg/kg/day (M/F) based on cumulative decreases in body-weight gains.

Cancer (oral, dermal, inhalation)	Difenoconazole is classified as a Group C, possible human carcinogen with a non-linear (MOE) approach for human risk characterization (CPRC Document, 7/27/94, Memo, P. V. Shah dated March 3, 2007, HED Doc. No. 0054532). The chronic dietary exposure assessment is protective of cancer effects.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and  used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures.  NOAEL = no observed adverse effect level.  LOAEL = lowest observed adverse effect level.  UF = uncertainty factor.  UFA = extrapolation from animal to human (interspecies).  UFH = potential variation in sensitivity among members of the human population (intraspecies).  FQPA SF = FQPA Safety Factor.  PAD = population adjusted dose (a = acute, c = chronic).  RfD = reference dose.

VI.   Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the aPAD or cPAD, respectively.  The following paragraphs are summaries of the DEEM-FCID( (ver. 2.03) acute and chronic exposure analyses.

Acute and chronic aggregate (food + water) analyses were performed using DEEM-FCID( estimating the dietary exposure of the U.S. population and various population subgroups.  The results are summarized in Tables 4 and 5 below for acute and chronic analyses respectively.

The resulting acute food exposure estimates were less than HED’s level of concern (<100% aPAD) at the 95th percentile of the exposure distribution for general US population (8 % aPAD) and all population sub-groups; the most highly exposed population subgroup was Children 1-2 years old with 19 % aPAD.  The resulting chronic food exposure estimates were less than HED’s level of concern (<100% cPAD) for the general U.S. population (17 % cPAD) and all population sub-groups; the most highly exposed population subgroup was children 1-2 years old with 46 % cPAD.   A separate cancer dietary assessment was not conducted for difenoconazole because the cancer NOAEL is higher than the chronic RfD; therefore, the chronic dietary risk estimate is considered protective of all chronic effects including carcinogenicity.

Table 4.  Summary of Acute Dietary (Food plus Water) Exposure and Risk for Difenoconazole at the 95th Percentile.

Population Subgroup

aPAD (mg/kg/day)

Exposure (mg/kg/day)

%aPAD

General U.S. Population

0.25

0.020538	8

All Infants (< 1 year old)

0.039780	16

Children 1-2 years old

0.047638	19

Children 3-5 years old

0.037050	15

Children 6-12 years old

0.021576	9

Youth 13-19 years old

0.011240	5

Adults 20-49 years old

0.014699	6

Adults 50+ years old

0.019351	8

Females 13-49 years old

0.015084	6

The bolded %aPAD is the highest.

Table 5.  Summary of Chronic Dietary (Food plus Water) Exposure and Risk for Difenoconazole.

Population Subgroup

cPAD (mg/kg/day)

Exposure (mg/kg/day)

%cPAD

General U.S. Population

0.01

0.001687	17

All Infants (< 1 year old)

0.003001	30

Children 1-2 years old

0.004573	46

Children 3-5 years old

0.003607	36

Children 6-12 years old

0.002027	20

Youth 13-19 years old

0.001307	13

Adults 20-49 years old

0.001317	13

Adults 50+ years old

0.001562	16

Females 13-49 years old

0.001373	14

The bolded %cPAD is the highest.

VII.   Characterization of Inputs/Outputs

The acute analysis assumed tolerance-level residues,  maximum expected residues for wheat grain and barley grain from field trials with a lower method LOQ, 100% CT, and empirical or DEEM( default processing factors.  The chronic analysis assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, 100 % CT, and empirical or DEEM( default processing factors.  Therefore, these analyses are considered conservative.  While they could be significantly refined, further refinement is not warranted as estimated risks are not of concern.

VIII.   Conclusions

An acute aggregate (food + water) dietary risk assessment was conducted for difenoconazole using the DEEM-FCID( (ver. 2.03) Model and assumed tolerance-level residues, maximum expected residues for wheat grain and barley grain from field trials with a lower method LOQ , 100% CT, and empirical or DEEM( default processing factors.  The chronic aggregate dietary risk assessment assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, 100 % CT, and empirical or DEEM( default processing factors.  The resulting acute and chronic aggregate exposure estimates were less than HED’s level of concern.  For the general U.S. population, the aPAD and cPAD were 8 % and 17 %, respectively.  The most highly-exposed population subgroups in the acute (at the 95th percentile of the exposure distribution) and chronic analyses were Children 1-2 years old (19 % aPAD) and children 1-2 years old (46 % cPAD), respectively.

IX.   Attachments

Attachment 1:	DEEM-FCID( Acute Residue File

Attachment 2:	DEEM-FCID( Acute Exposure Estimates

Attachment 3:	DEEM-FCID( Chronic Residue File

Attachment 4:	DEEM-FCID( Chronic Exposure Estimates

cc with all attachments:  T. Morton (RABIV)

RDI: D. McNeilly and D. Hrdy - DESAC (26-October-2011); S. Hummel (26-October-2011)

Petition Number(s): 0F7785

DP#: 389652

PC Code: 128847

T. Morton:S10838:PY1:(703)305-6691

Attachment 1:  DEEM-FCID( Acute Residue File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 Difenoconazole 0F7785 May 2011\difenoconazole_acute-05-11.R98

Chemical: Difenoconazole

RfD(Chronic): .01 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 05-10-2011/07:02:12/8          Program ver. 2.03

------------------------------------------------------------------------ --------

  EPA    Crop                                   Def Res     Adj.Factors   Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2

-------- ---- -------------------------------  ----------  ------ ------  -------

01010520 1A   Beet, sugar                        0.300000   1.000  1.000

01010521 1A   Beet, sugar-babyfood               0.300000   1.000  1.000

01010530 1A   Beet, sugar, molasses              0.300000   0.600  1.000

01010531 1A   Beet, sugar, molasses-babyfood     0.300000   0.600  1.000

01010780 1AB  Carrot                             0.500000   1.000  1.000

01010781 1AB  Carrot-babyfood                    0.500000   1.000  1.000

01010790 1AB  Carrot, juice                      0.500000   1.000  1.000

01032960 1C   Potato, chips                      0.010000   0.500  1.000

01032970 1C   Potato, dry (granules/ flakes)     0.010000   0.500  1.000

01032971 1C   Potato, dry (granules/ flakes)-b   0.010000   0.500  1.000

01032980 1C   Potato, flour                      0.010000   0.500  1.000

01032981 1C   Potato, flour-babyfood             0.010000   0.500  1.000

01032990 1C   Potato, tuber, w/peel              0.010000   1.000  1.000

01032991 1C   Potato, tuber, w/peel-babyfood     0.010000   1.000  1.000

01033000 1C   Potato, tuber, w/o peel            0.010000   1.000  1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.010000   1.000  1.000

03001640 3    Garlic                             0.200000   1.000  1.000

03001650 3    Garlic, dried                      0.200000   1.000  1.000

03001651 3    Garlic, dried-babyfood             0.200000   1.000  1.000

03001980 3    Leek                               6.000000   1.000  1.000

03002370 3    Onion, dry bulb                    0.200000   1.000  1.000

03002371 3    Onion, dry bulb-babyfood           0.200000   1.000  1.000

03002380 3    Onion, dry bulb, dried             0.200000   9.000  1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.200000   9.000  1.000

03002390 3    Onion, green                       6.000000   1.000  1.000

03003380 3    Shallot                            0.200000   1.000  1.000

05010610 5A   Broccoli                           1.900000   1.000  1.000

05010611 5A   Broccoli-babyfood                  1.900000   1.000  1.000

05010620 5A   Broccoli, Chinese                  1.900000   1.000  1.000

05010640 5A   Brussels sprouts                   1.900000   1.000  1.000

05010690 5A   Cabbage                            1.900000   1.000  1.000

05010710 5A   Cabbage, Chinese, napa             1.900000   1.000  1.000

05010720 5A   Cabbage, Chinese, mustard          1.900000   1.000  1.000

05010830 5A   Cauliflower                        1.900000   1.000  1.000

05011960 5A   Kohlrabi                           1.900000   1.000  1.000

05020630 5B   Broccoli raab                     35.000000   1.000  1.000

05020700 5B   Cabbage, Chinese, bok choy        35.000000   1.000  1.000

05021170 5B   Collards                          35.000000   1.000  1.000

05021940 5B   Kale                              35.000000   1.000  1.000

05022290 5B   Mustard greens                    35.000000   1.000  1.000

05023180 5B   Rape greens                       35.000000   1.000  1.000

05023890 5B   Turnip, greens                    35.000000   1.000  1.000

06003470 6    Soybean, seed                      0.150000   1.000  1.000

06003480 6    Soybean, flour                     0.150000   1.000  1.000

06003481 6    Soybean, flour-babyfood            0.150000   1.000  1.000

06003490 6    Soybean, soy milk                  0.150000   1.000  1.000

06003491 6    Soybean, soy milk-babyfood or in   0.150000   1.000  1.000

06003500 6    Soybean, oil                       0.150000   1.000  1.000

06003501 6    Soybean, oil-babyfood              0.150000   1.000  1.000

06030980 6C   Chickpea, seed                     0.080000   1.000  1.000

06030981 6C   Chickpea, seed-babyfood            0.080000   1.000  1.000

06030990 6C   Chickpea, flour                    0.080000   1.000  1.000

08001480 8    Eggplant                           0.600000   1.000  1.000

08002340 8    Okra                               0.600000   1.000  1.000

08002700 8    Pepper, bell                       0.600000   1.000  1.000

08002701 8    Pepper, bell-babyfood              0.600000   1.000  1.000

08002710 8    Pepper, bell, dried                0.600000   1.000  1.000

08002711 8    Pepper, bell, dried-babyfood       0.600000   1.000  1.000

08002720 8    Pepper, nonbell                    0.600000   1.000  1.000

08002721 8    Pepper, nonbell-babyfood           0.600000   1.000  1.000

08002730 8    Pepper, nonbell, dried             0.600000   1.000  1.000

08003740 8    Tomatillo                          0.600000   1.000  1.000

08003750 8    Tomato                             0.600000   1.000  1.000

08003751 8    Tomato-babyfood                    0.600000   1.000  1.000

08003760 8    Tomato, paste                      0.600000   1.600  1.000

08003761 8    Tomato, paste-babyfood             0.600000   1.600  1.000

08003770 8    Tomato, puree                      0.600000   0.500  1.000

08003771 8    Tomato, puree-babyfood             0.600000   0.500  1.000

08003780 8    Tomato, dried                      0.600000  14.300  1.000

08003781 8    Tomato, dried-babyfood             0.600000  14.300  1.000

08003790 8    Tomato, juice                      0.600000   1.500  1.000

09010750 9A   Cantaloupe                         0.700000   1.000  1.000

09010800 9A   Casaba                             0.700000   1.000  1.000

09011870 9A   Honeydew melon                     0.700000   1.000  1.000

09013990 9A   Watermelon                         0.700000   1.000  1.000

09014000 9A   Watermelon, juice                  0.700000   1.000  1.000

09020210 9B   Balsam pear                        0.700000   1.000  1.000

09020880 9B   Chayote, fruit                     0.700000   1.000  1.000

09021020 9B   Chinese waxgourd                   0.700000   1.000  1.000

09021350 9B   Cucumber                           0.700000   1.000  1.000

09023080 9B   Pumpkin                            0.700000   1.000  1.000

09023090 9B   Pumpkin, seed                      0.700000   1.000  1.000

09023560 9B   Squash, summer                     0.700000   1.000  1.000

09023561 9B   Squash, summer-babyfood            0.700000   1.000  1.000

09023570 9B   Squash, winter                     0.700000   1.000  1.000

09023571 9B   Squash, winter-babyfood            0.700000   1.000  1.000

10001060 10   Citrus citron                      0.600000   1.000  1.000

10001070 10   Citrus hybrids                     0.600000   1.000  1.000

10001080 10   Citrus, oil                       25.000000   1.000  1.000

10001800 10   Grapefruit                         0.600000   1.000  1.000

10001810 10   Grapefruit, juice                  0.600000   0.100  1.000

10001970 10   Kumquat                            0.600000   1.000  1.000

10001990 10   Lemon                              0.600000   1.000  1.000

10002000 10   Lemon, juice                       0.600000   0.100  1.000

10002001 10   Lemon, juice-babyfood              0.600000   0.100  1.000

10002010 10   Lemon, peel                        0.600000   1.000  1.000

10002060 10   Lime                               0.600000   1.000  1.000

10002070 10   Lime, juice                        0.600000   0.100  1.000

10002071 10   Lime, juice-babyfood               0.600000   0.100  1.000

10002400 10   Orange                             0.600000   1.000  1.000

10002410 10   Orange, juice                      0.600000   0.100  1.000

10002411 10   Orange, juice-babyfood             0.600000   0.100  1.000

10002420 10   Orange, peel                       0.600000   1.000  1.000

10003070 10   Pummelo                            0.600000   1.000  1.000

10003690 10   Tangerine                          0.600000   1.000  1.000

10003700 10   Tangerine, juice                   0.600000   0.100  1.000

11000070 11   Apple, fruit with peel             1.000000   1.000  1.000

11000080 11   Apple, peeled fruit                1.000000   1.000  1.000

11000081 11   Apple, peeled fruit-babyfood       1.000000   1.000  1.000

11000090 11   Apple, dried                       1.000000   8.000  1.000

11000091 11   Apple, dried-babyfood              1.000000   8.000  1.000

11000100 11   Apple, juice                       1.000000   0.040  1.000

11000101 11   Apple, juice-babyfood              1.000000   0.040  1.000

11000110 11   Apple, sauce                       1.000000   1.000  1.000

11000111 11   Apple, sauce-babyfood              1.000000   1.000  1.000

11001290 11   Crabapple                          1.000000   1.000  1.000

11002100 11   Loquat                             1.000000   1.000  1.000

11002660 11   Pear                               1.000000   1.000  1.000

11002661 11   Pear-babyfood                      1.000000   1.000  1.000

11002670 11   Pear, dried                        1.000000   6.250  1.000

11002680 11   Pear, juice                        1.000000   1.000  1.000

11002681 11   Pear, juice-babyfood               1.000000   1.000  1.000

11003100 11   Quince                             1.000000   1.000  1.000

12000120 12   Apricot                            2.500000   1.000  1.000

12000121 12   Apricot-babyfood                   2.500000   1.000  1.000

12000130 12   Apricot, dried                     2.500000   1.000  1.000

12000140 12   Apricot, juice                     2.500000   1.000  1.000

12000141 12   Apricot, juice-babyfood            2.500000   1.000  1.000

12000900 12   Cherry                             2.500000   1.000  1.000

12000901 12   Cherry-babyfood                    2.500000   1.000  1.000

12000910 12   Cherry, juice                      2.500000   1.000  1.000

12000911 12   Cherry, juice-babyfood             2.500000   1.000  1.000

12002300 12   Nectarine                          2.500000   1.000  1.000

12002600 12   Peach                              2.500000   1.000  1.000

12002601 12   Peach-babyfood                     2.500000   1.000  1.000

12002610 12   Peach, dried                       2.500000   1.000  1.000

12002611 12   Peach, dried-babyfood              2.500000   1.000  1.000

12002620 12   Peach, juice                       2.500000   1.000  1.000

12002621 12   Peach, juice-babyfood              2.500000   1.000  1.000

12002850 12   Plum                               2.500000   1.000  1.000

12002851 12   Plum-babyfood                      2.500000   1.000  1.000

12002860 12   Plum, prune, fresh                 2.500000   1.000  1.000

12002861 12   Plum, prune, fresh-babyfood        2.500000   1.000  1.000

12002870 12   Plum, prune, dried                 2.500000   1.000  1.000

12002871 12   Plum, prune, dried-babyfood        2.500000   1.000  1.000

12002880 12   Plum, prune, juice                 2.500000   1.000  1.000

12002881 12   Plum, prune, juice-babyfood        2.500000   1.000  1.000

14000030 14   Almond                             0.030000   1.000  1.000

14000031 14   Almond-babyfood                    0.030000   1.000  1.000

14000040 14   Almond, oil                        0.030000   1.000  1.000

14000041 14   Almond, oil-babyfood               0.030000   1.000  1.000

14000590 14   Brazil nut                         0.030000   1.000  1.000

14000680 14   Butternut                          0.030000   1.000  1.000

14000810 14   Cashew                             0.030000   1.000  1.000

14000920 14   Chestnut                           0.030000   1.000  1.000

14001550 14   Filbert                            0.030000   1.000  1.000

14001560 14   Filbert, oil                       0.030000   1.000  1.000

14001850 14   Hickory nut                        0.030000   1.000  1.000

14002130 14   Macadamia nut                      0.030000   1.000  1.000

14002690 14   Pecan                              0.030000   1.000  1.000

14002820 14   Pistachio                          0.030000   1.000  1.000

14003910 14   Walnut                             0.030000   1.000  1.000

15000250 15   Barley, pearled barley             0.010000   1.000  1.000

15000251 15   Barley, pearled barley-babyfood    0.010000   1.000  1.000

15000260 15   Barley, flour                      0.010000   1.000  1.000

15000261 15   Barley, flour-babyfood             0.010000   1.000  1.000

15000270 15   Barley, bran                       0.010000   1.000  1.000

15001270 15   Corn, sweet                        0.010000   1.000  1.000

15001271 15   Corn, sweet-babyfood               0.010000   1.000  1.000

15002310 15   Oat, bran                          0.010000   1.000  1.000

15002320 15   Oat, flour                         0.010000   1.000  1.000

15002321 15   Oat, flour-babyfood                0.010000   1.000  1.000

15002330 15   Oat, groats/rolled oats            0.010000   1.000  1.000

15002331 15   Oat, groats/rolled oats-babyfood   0.010000   1.000  1.000

15003280 15   Rye, grain                         0.010000   1.000  1.000

15003290 15   Rye, flour                         0.010000   1.000  1.000

15004010 15   Wheat, grain                       0.020000   1.000  1.000

15004011 15   Wheat, grain-babyfood              0.020000   1.000  1.000

15004020 15   Wheat, flour                       0.020000   1.000  1.000

15004021 15   Wheat, flour-babyfood              0.020000   1.000  1.000

15004030 15   Wheat, germ                        0.020000   1.000  1.000

15004040 15   Wheat, bran                        0.020000   1.000  1.000

20003190 20   Rapeseed, oil                      0.010000   1.000  1.000

20003191 20   Rapeseed, oil-babyfood             0.010000   1.000  1.000

21000440 M    Beef, meat                         0.050000   1.000  1.000

21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000

21000450 M    Beef, meat, dried                  0.050000   1.920  1.000

21000460 M    Beef, meat byproducts              0.100000   1.000  1.000

21000461 M    Beef, meat byproducts-babyfood     0.100000   1.000  1.000

21000470 M    Beef, fat                          0.100000   1.000  1.000

21000471 M    Beef,fat-babyfood                  0.100000   1.000  1.000

21000480 M    Beef, kidney                       0.100000   1.000  1.000

21000490 M    Beef, liver                        0.400000   1.000  1.000

21000491 M    Beef, liver-babyfood               0.400000   1.000  1.000

23001690 M    Goat, meat                         0.050000   1.000  1.000

23001700 M    Goat, meat byproducts              0.100000   1.000  1.000

23001710 M    Goat, fat                          0.100000   1.000  1.000

23001720 M    Goat, kidney                       0.100000   1.000  1.000

23001730 M    Goat, liver                        0.400000   1.000  1.000

24001890 M    Horse, meat                        0.050000   1.000  1.000

25002900 M    Pork, meat                         0.050000   1.000  1.000

25002901 M    Pork, meat-babyfood                0.050000   1.000  1.000

25002910 M    Pork, skin                         0.100000   1.000  1.000

25002920 M    Pork, meat byproducts              0.100000   1.000  1.000

25002921 M    Pork, meat byproducts-babyfood     0.100000   1.000  1.000

25002930 M    Pork, fat                          0.100000   1.000  1.000

25002931 M    Pork, fat-babyfood                 0.100000   1.000  1.000

25002940 M    Pork, kidney                       0.100000   1.000  1.000

25002950 M    Pork, liver                        0.400000   1.000  1.000

26003390 M    Sheep, meat                        0.050000   1.000  1.000

26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000

26003400 M    Sheep, meat byproducts             0.100000   1.000  1.000

26003410 M    Sheep, fat                         0.100000   1.000  1.000

26003411 M    Sheep, fat-babyfood                0.100000   1.000  1.000

26003420 M    Sheep, kidney                      0.100000   1.000  1.000

26003430 M    Sheep, liver                       0.400000   1.000  1.000

27002220 D    Milk, fat                          0.010000   1.000  1.000

27002221 D    Milk, fat - baby food/infant for   0.010000   1.000  1.000

27012230 D    Milk, nonfat solids                0.010000   1.000  1.000

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000  1.000

27022240 D    Milk, water                        0.010000   1.000  1.000

27022241 D    Milk, water-babyfood/infant form   0.010000   1.000  1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000  1.000

70001450 P    Egg, whole                         0.020000   1.000  1.000

70001451 P    Egg, whole-babyfood                0.020000   1.000  1.000

70001460 P    Egg, white                         0.020000   1.000  1.000

70001461 P    Egg, white (solids)-babyfood       0.020000   1.000  1.000

70001470 P    Egg, yolk                          0.020000   1.000  1.000

70001471 P    Egg, yolk-babyfood                 0.020000   1.000  1.000

86010000 O    Water, direct, all sources         0.015800   1.000  1.000

86020000 O    Water, indirect, all sources       0.015800   1.000  1.000

95000230 O    Banana                             0.200000   1.000  1.000

95000231 O    Banana-babyfood                    0.200000   1.000  1.000

95000240 O    Banana, dried                      0.200000   3.900  1.000

95000241 O    Banana, dried-babyfood             0.200000   3.900  1.000

95001280 O    Cottonseed, oil                    0.050000   1.000  1.000

95001281 O    Cottonseed, oil-babyfood           0.050000   1.000  1.000

95001750 O    Grape                              4.000000   1.000  1.000

95001760 O    Grape, juice                       4.000000   0.200  1.000

95001761 O    Grape, juice-babyfood              4.000000   0.200  1.000

95001770 O    Grape, leaves                      4.000000   1.000  1.000

95001780 O    Grape, raisin                      6.000000   1.000  1.000

95001790 O    Grape, wine and sherry             4.000000   1.000  1.000

95002150 O    Mango                              0.070000   1.000  1.000

95002151 O    Mango-babyfood                     0.070000   1.000  1.000

95002160 O    Mango, dried                       0.070000   1.000  1.000

95002170 O    Mango, juice                       0.070000   1.000  1.000

95002171 O    Mango, juice-babyfood              0.070000   1.000  1.000

95002450 O    Papaya                             0.300000   1.000  1.000

95002451 O    Papaya-babyfood                    0.300000   1.000  1.000

95002460 O    Papaya, dried                      0.300000   1.800  1.000

95002470 O    Papaya, juice                      0.300000   1.500  1.000

95002830 O    Plantain                           0.200000   1.000  1.000

95002840 O    Plantain, dried                    0.200000   3.900  1.000

95003590 O    Strawberry                         2.500000   1.000  1.000

95003591 O    Strawberry-babyfood                2.500000   1.000  1.000

95003600 O    Strawberry, juice                  2.500000   1.000  1.000

95003601 O    Strawberry, juice-babyfood         2.500000   1.000  1.000

Attachment 2:  DEEM-FCID( Acute Exposure Estimates

U.S. Environmental Protection Agency                                  Ver. 2.02

DEEM-FCID ACUTE Analysis for DIFENOCONAZOLE                      (1994-98 data)

Residue file: difenoconazole_acute-05-11.R98          Adjustment factor #2 used.

Analysis Date: 05-10-2011/07:05:35    Residue file dated: 05-10-2011/07:02:12/8

Daily totals for food and foodform consumption used.

Run Comment: ""

======================================================================== =======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure   % aRfD

                  ---------- --------  ---------- --------  ---------- --------

U.S. Population:

                    0.020538     8.22    0.055384    22.15    0.143944    57.58

All infants:

                    0.039780    15.91    0.062606    25.04    0.118345    47.34

Children 1-2 yrs:

                    0.047638    19.06    0.094024    37.61    0.252955   101.18

Children 3-5 yrs:

                    0.037050    14.82    0.076959    30.78    0.375828   150.33

Children 6-12 yrs:

                    0.021576     8.63    0.044683    17.87    0.148114    59.25

Youth 13-19 yrs:

                    0.011240     4.50    0.039654    15.86    0.137650    55.06

Adults 20-49 yrs:

                    0.014699     5.88    0.041863    16.75    0.109721    43.89

Adults 50+ yrs:

                    0.019351     7.74    0.063235    25.29    0.138873    55.55

Females 13-49 yrs:

                    0.015084     6.03    0.042143    16.86    0.121368    48.55

Attachment 3:  DEEM-FCID( Chronic Residue File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 Difenoconazole 0F7785 May 2011\difenoconazole_chronic-05-11AverageFT.R98

Chemical: Difenoconazole

RfD(Chronic): .01 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 05-10-2011/07:03:40/8          Program ver. 2.03

------------------------------------------------------------------------ --------

  EPA    Crop                                   Def Res     Adj.Factors   Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2

-------- ---- -------------------------------  ----------  ------ ------  -------

01010520 1A   Beet, sugar                        0.300000   1.000  1.000

01010521 1A   Beet, sugar-babyfood               0.300000   1.000  1.000

01010530 1A   Beet, sugar, molasses              0.300000   0.600  1.000

01010531 1A   Beet, sugar, molasses-babyfood     0.300000   0.600  1.000

01010780 1AB  Carrot                             0.062000   1.000  1.000

01010781 1AB  Carrot-babyfood                    0.062000   1.000  1.000

01010790 1AB  Carrot, juice                      0.062000   1.000  1.000

01032960 1C   Potato, chips                      0.005000   0.500  1.000

01032970 1C   Potato, dry (granules/ flakes)     0.005000   0.500  1.000

01032971 1C   Potato, dry (granules/ flakes)-b   0.005000   0.500  1.000

01032980 1C   Potato, flour                      0.005000   0.500  1.000

01032981 1C   Potato, flour-babyfood             0.005000   0.500  1.000

01032990 1C   Potato, tuber, w/peel              0.005000   1.000  1.000

01032991 1C   Potato, tuber, w/peel-babyfood     0.005000   1.000  1.000

01033000 1C   Potato, tuber, w/o peel            0.005000   1.000  1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.005000   1.000  1.000

03001640 3    Garlic                             0.200000   1.000  1.000

03001650 3    Garlic, dried                      0.200000   1.000  1.000

03001651 3    Garlic, dried-babyfood             0.200000   1.000  1.000

03001980 3    Leek                               6.000000   1.000  1.000

03002370 3    Onion, dry bulb                    0.200000   1.000  1.000

03002371 3    Onion, dry bulb-babyfood           0.200000   1.000  1.000

03002380 3    Onion, dry bulb, dried             0.200000   9.000  1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.200000   9.000  1.000

03002390 3    Onion, green                       6.000000   1.000  1.000

03003380 3    Shallot                            0.200000   1.000  1.000

05010610 5A   Broccoli                           0.221000   1.000  1.000

05010611 5A   Broccoli-babyfood                  0.221000   1.000  1.000

05010620 5A   Broccoli, Chinese                  0.221000   1.000  1.000

05010640 5A   Brussels sprouts                  29.000000   1.000  1.000

05010690 5A   Cabbage                            0.029000   1.000  1.000

05010710 5A   Cabbage, Chinese, napa             0.029000   1.000  1.000

05010720 5A   Cabbage, Chinese, mustard          0.221000   1.000  1.000

05010830 5A   Cauliflower                        0.221000   1.000  1.000

05011960 5A   Kohlrabi                           0.029000   1.000  1.000

05020630 5B   Broccoli raab                      5.100000   1.000  1.000

05020700 5B   Cabbage, Chinese, bok choy         5.100000   1.000  1.000

05021170 5B   Collards                           5.100000   1.000  1.000

05021940 5B   Kale                               5.100000   1.000  1.000

05022290 5B   Mustard greens                     5.100000   1.000  1.000

05023180 5B   Rape greens                        5.100000   1.000  1.000

05023890 5B   Turnip, greens                     5.100000   1.000  1.000

06003470 6    Soybean, seed                      0.021500   1.000  1.000

06003480 6    Soybean, flour                     0.021500   1.000  1.000

06003481 6    Soybean, flour-babyfood            0.021500   1.000  1.000

06003490 6    Soybean, soy milk                  0.021500   1.000  1.000

06003491 6    Soybean, soy milk-babyfood or in   0.021500   1.000  1.000

06003500 6    Soybean, oil                       0.021500   1.000  1.000

06003501 6    Soybean, oil-babyfood              0.021500   1.000  1.000

06030980 6C   Chickpea, seed                     0.017000   1.000  1.000

06030981 6C   Chickpea, seed-babyfood            0.017000   1.000  1.000

06030990 6C   Chickpea, flour                    0.017000   1.000  1.000

08001480 8    Eggplant                           0.133000   1.000  1.000

08002340 8    Okra                               0.600000   1.000  1.000

08002700 8    Pepper, bell                       0.133000   1.000  1.000

08002701 8    Pepper, bell-babyfood              0.133000   1.000  1.000

08002710 8    Pepper, bell, dried                0.133000   1.000  1.000

08002711 8    Pepper, bell, dried-babyfood       0.133000   1.000  1.000

08002720 8    Pepper, nonbell                    0.133000   1.000  1.000

08002721 8    Pepper, nonbell-babyfood           0.133000   1.000  1.000

08002730 8    Pepper, nonbell, dried             0.133000   1.000  1.000

08003740 8    Tomatillo                          0.165000   1.000  1.000

08003750 8    Tomato                             0.165000   1.000  1.000

08003751 8    Tomato-babyfood                    0.165000   1.000  1.000

08003760 8    Tomato, paste                      0.165000   1.600  1.000

08003761 8    Tomato, paste-babyfood             0.165000   1.600  1.000

08003770 8    Tomato, puree                      0.165000   0.500  1.000

08003771 8    Tomato, puree-babyfood             0.165000   0.500  1.000

08003780 8    Tomato, dried                      0.165000  14.300  1.000

08003781 8    Tomato, dried-babyfood             0.165000  14.300  1.000

08003790 8    Tomato, juice                      0.165000   1.500  1.000

09010750 9A   Cantaloupe                         0.137000   1.000  1.000

09010800 9A   Casaba                             0.137000   1.000  1.000

09011870 9A   Honeydew melon                     0.137000   1.000  1.000

09013990 9A   Watermelon                         0.137000   1.000  1.000

09014000 9A   Watermelon, juice                  0.137000   1.000  1.000

09020210 9B   Balsam pear                        0.055000   1.000  1.000

09020880 9B   Chayote, fruit                     0.310000   1.000  1.000

09021020 9B   Chinese waxgourd                   0.055000   1.000  1.000

09021350 9B   Cucumber                           0.055000   1.000  1.000

09023080 9B   Pumpkin                            0.031000   1.000  1.000

09023090 9B   Pumpkin, seed                      0.031000   1.000  1.000

09023560 9B   Squash, summer                     0.031000   1.000  1.000

09023561 9B   Squash, summer-babyfood            0.031000   1.000  1.000

09023570 9B   Squash, winter                     0.031000   1.000  1.000

09023571 9B   Squash, winter-babyfood            0.031000   1.000  1.000

10001060 10   Citrus citron                      0.208000   1.000  1.000

10001070 10   Citrus hybrids                     0.208000   1.000  1.000

10001080 10   Citrus, oil                       25.000000   1.000  1.000

10001800 10   Grapefruit                         0.120000   1.000  1.000

10001810 10   Grapefruit, juice                  0.120000   0.100  1.000

10001970 10   Kumquat                            0.208000   1.000  1.000

10001990 10   Lemon                              0.176000   1.000  1.000

10002000 10   Lemon, juice                       0.176000   0.100  1.000

10002001 10   Lemon, juice-babyfood              0.176000   0.100  1.000

10002010 10   Lemon, peel                        0.176000   1.000  1.000

10002060 10   Lime                               0.176000   1.000  1.000

10002070 10   Lime, juice                        0.176000   0.100  1.000

10002071 10   Lime, juice-babyfood               0.176000   0.100  1.000

10002400 10   Orange                             0.208000   1.000  1.000

10002410 10   Orange, juice                      0.208000   0.100  1.000

10002411 10   Orange, juice-babyfood             0.208000   0.100  1.000

10002420 10   Orange, peel                       0.208000   1.000  1.000

10003070 10   Pummelo                            0.120000   1.000  1.000

10003690 10   Tangerine                          0.208000   1.000  1.000

10003700 10   Tangerine, juice                   0.208000   0.100  1.000

11000070 11   Apple, fruit with peel             0.203000   1.000  1.000

11000080 11   Apple, peeled fruit                0.203000   1.000  1.000

11000081 11   Apple, peeled fruit-babyfood       0.203000   1.000  1.000

11000090 11   Apple, dried                       0.203000   8.000  1.000

11000091 11   Apple, dried-babyfood              0.203000   8.000  1.000

11000100 11   Apple, juice                       0.203000   0.040  1.000

11000101 11   Apple, juice-babyfood              0.203000   0.040  1.000

11000110 11   Apple, sauce                       0.203000   1.000  1.000

11000111 11   Apple, sauce-babyfood              0.203000   1.000  1.000

11001290 11   Crabapple                          0.203000   1.000  1.000

11002100 11   Loquat                             0.123000   1.000  1.000

11002660 11   Pear                               0.123000   1.000  1.000

11002661 11   Pear-babyfood                      0.123000   1.000  1.000

11002670 11   Pear, dried                        0.123000   6.250  1.000

11002680 11   Pear, juice                        0.123000   1.000  1.000

11002681 11   Pear, juice-babyfood               0.123000   1.000  1.000

11003100 11   Quince                             0.123000   1.000  1.000

12000120 12   Apricot                            0.421000   1.000  1.000

12000121 12   Apricot-babyfood                   0.421000   1.000  1.000

12000130 12   Apricot, dried                     0.421000   1.000  1.000

12000140 12   Apricot, juice                     0.421000   1.000  1.000

12000141 12   Apricot, juice-babyfood            0.421000   1.000  1.000

12000900 12   Cherry                             0.622000   1.000  1.000

12000901 12   Cherry-babyfood                    0.622000   1.000  1.000

12000910 12   Cherry, juice                      0.622000   1.000  1.000

12000911 12   Cherry, juice-babyfood             0.622000   1.000  1.000

12002300 12   Nectarine                          0.421000   1.000  1.000

12002600 12   Peach                              0.421000   1.000  1.000

12002601 12   Peach-babyfood                     0.421000   1.000  1.000

12002610 12   Peach, dried                       0.421000   1.000  1.000

12002611 12   Peach, dried-babyfood              0.421000   1.000  1.000

12002620 12   Peach, juice                       0.421000   1.000  1.000

12002621 12   Peach, juice-babyfood              0.421000   1.000  1.000

12002850 12   Plum                               0.295000   1.000  1.000

12002851 12   Plum-babyfood                      0.295000   1.000  1.000

12002860 12   Plum, prune, fresh                 0.295000   1.000  1.000

12002861 12   Plum, prune, fresh-babyfood        0.295000   1.000  1.000

12002870 12   Plum, prune, dried                 0.295000   2.600  1.000

12002871 12   Plum, prune, dried-babyfood        0.295000   2.600  1.000

12002880 12   Plum, prune, juice                 0.295000   1.000  1.000

12002881 12   Plum, prune, juice-babyfood        0.295000   1.000  1.000

14000030 14   Almond                             0.005000   1.000  1.000

14000031 14   Almond-babyfood                    0.005000   1.000  1.000

14000040 14   Almond, oil                        0.005000   1.000  1.000

14000041 14   Almond, oil-babyfood               0.005000   1.000  1.000

14000590 14   Brazil nut                         0.007000   1.000  1.000

14000680 14   Butternut                          0.007000   1.000  1.000

14000810 14   Cashew                             0.007000   1.000  1.000

14000920 14   Chestnut                           0.005000   1.000  1.000

14001550 14   Filbert                            0.007000   1.000  1.000

14001560 14   Filbert, oil                       0.007000   1.000  1.000

14001850 14   Hickory nut                        0.007000   1.000  1.000

14002130 14   Macadamia nut                      0.007000   1.000  1.000

14002690 14   Pecan                              0.007000   1.000  1.000

14002820 14   Pistachio                          0.005000   1.000  1.000

14003910 14   Walnut                             0.007000   1.000  1.000

15000250 15   Barley, pearled barley             0.010000   1.000  1.000

15000251 15   Barley, pearled barley-babyfood    0.010000   1.000  1.000

15000260 15   Barley, flour                      0.010000   1.000  1.000

15000261 15   Barley, flour-babyfood             0.010000   1.000  1.000

15000270 15   Barley, bran                       0.010000   1.000  1.000

15001270 15   Corn, sweet                        0.010000   1.000  1.000

15001271 15   Corn, sweet-babyfood               0.010000   1.000  1.000

15002310 15   Oat, bran                          0.010000   1.000  1.000

15002320 15   Oat, flour                         0.010000   1.000  1.000

15002321 15   Oat, flour-babyfood                0.010000   1.000  1.000

15002330 15   Oat, groats/rolled oats            0.010000   1.000  1.000

15002331 15   Oat, groats/rolled oats-babyfood   0.010000   1.000  1.000

15003280 15   Rye, grain                         0.010000   1.000  1.000

15003290 15   Rye, flour                         0.010000   1.000  1.000

15004010 15   Wheat, grain                       0.020000   1.000  1.000

15004011 15   Wheat, grain-babyfood              0.020000   1.000  1.000

15004020 15   Wheat, flour                       0.020000   1.000  1.000

15004021 15   Wheat, flour-babyfood              0.020000   1.000  1.000

15004030 15   Wheat, germ                        0.020000   1.000  1.000

15004040 15   Wheat, bran                        0.020000   1.000  1.000

20003190 20   Rapeseed, oil                      0.010000   1.000  1.000

20003191 20   Rapeseed, oil-babyfood             0.010000   1.000  1.000

21000440 M    Beef, meat                         0.050000   1.000  1.000

21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000

21000450 M    Beef, meat, dried                  0.050000   1.920  1.000

21000460 M    Beef, meat byproducts              0.100000   1.000  1.000

21000461 M    Beef, meat byproducts-babyfood     0.100000   1.000  1.000

21000470 M    Beef, fat                          0.100000   1.000  1.000

21000471 M    Beef,fat-babyfood                  0.100000   1.000  1.000

21000480 M    Beef, kidney                       0.100000   1.000  1.000

21000490 M    Beef, liver                        0.400000   1.000  1.000

21000491 M    Beef, liver-babyfood               0.400000   1.000  1.000

23001690 M    Goat, meat                         0.050000   1.000  1.000

23001700 M    Goat, meat byproducts              0.100000   1.000  1.000

23001710 M    Goat, fat                          0.100000   1.000  1.000

23001720 M    Goat, kidney                       0.100000   1.000  1.000

23001730 M    Goat, liver                        0.400000   1.000  1.000

24001890 M    Horse, meat                        0.050000   1.000  1.000

25002900 M    Pork, meat                         0.050000   1.000  1.000

25002901 M    Pork, meat-babyfood                0.050000   1.000  1.000

25002910 M    Pork, skin                         0.100000   1.000  1.000

25002920 M    Pork, meat byproducts              0.100000   1.000  1.000

25002921 M    Pork, meat byproducts-babyfood     0.100000   1.000  1.000

25002930 M    Pork, fat                          0.100000   1.000  1.000

25002931 M    Pork, fat-babyfood                 0.100000   1.000  1.000

25002940 M    Pork, kidney                       0.100000   1.000  1.000

25002950 M    Pork, liver                        0.400000   1.000  1.000

26003390 M    Sheep, meat                        0.050000   1.000  1.000

26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000

26003400 M    Sheep, meat byproducts             0.100000   1.000  1.000

26003410 M    Sheep, fat                         0.100000   1.000  1.000

26003411 M    Sheep, fat-babyfood                0.100000   1.000  1.000

26003420 M    Sheep, kidney                      0.100000   1.000  1.000

26003430 M    Sheep, liver                       0.400000   1.000  1.000

27002220 D    Milk, fat                          0.010000   1.000  1.000

27002221 D    Milk, fat - baby food/infant for   0.010000   1.000  1.000

27012230 D    Milk, nonfat solids                0.010000   1.000  1.000

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000  1.000

27022240 D    Milk, water                        0.010000   1.000  1.000

27022241 D    Milk, water-babyfood/infant form   0.010000   1.000  1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000  1.000

70001450 P    Egg, whole                         0.020000   1.000  1.000

70001451 P    Egg, whole-babyfood                0.020000   1.000  1.000

70001460 P    Egg, white                         0.020000   1.000  1.000

70001461 P    Egg, white (solids)-babyfood       0.020000   1.000  1.000

70001470 P    Egg, yolk                          0.020000   1.000  1.000

70001471 P    Egg, yolk-babyfood                 0.020000   1.000  1.000

86010000 O    Water, direct, all sources         0.010400   1.000  1.000

86020000 O    Water, indirect, all sources       0.010400   1.000  1.000

95000230 O    Banana                             0.200000   1.000  1.000

95000231 O    Banana-babyfood                    0.200000   1.000  1.000

95000240 O    Banana, dried                      0.200000   3.900  1.000

95000241 O    Banana, dried-babyfood             0.200000   3.900  1.000

95001280 O    Cottonseed, oil                    0.050000   1.000  1.000

95001281 O    Cottonseed, oil-babyfood           0.050000   1.000  1.000

95001750 O    Grape                              0.613000   1.000  1.000

95001760 O    Grape, juice                       0.613000   0.200  1.000

95001761 O    Grape, juice-babyfood              0.613000   0.200  1.000

95001770 O    Grape, leaves                      0.613000   1.000  1.000

95001780 O    Grape, raisin                      0.613000   3.500  1.000

95001790 O    Grape, wine and sherry             0.613000   1.000  1.000

95002150 O    Mango                              0.070000   1.000  1.000

95002151 O    Mango-babyfood                     0.070000   1.000  1.000

95002160 O    Mango, dried                       0.070000   1.000  1.000

95002170 O    Mango, juice                       0.070000   1.000  1.000

95002171 O    Mango, juice-babyfood              0.070000   1.000  1.000

95002450 O    Papaya                             0.300000   1.000  1.000

95002451 O    Papaya-babyfood                    0.300000   1.000  1.000

95002460 O    Papaya, dried                      0.300000   1.800  1.000

95002470 O    Papaya, juice                      0.300000   1.500  1.000

95002830 O    Plantain                           0.200000   1.000  1.000

95002840 O    Plantain, dried                    0.200000   3.900  1.000

95003590 O    Strawberry                         0.495000   1.000  1.000

95003591 O    Strawberry-babyfood                0.495000   1.000  1.000

95003600 O    Strawberry, juice                  0.495000   1.000  1.000

95003601 O    Strawberry, juice-babyfood         0.495000   1.000  1.000

Attachment 4:  DEEM-FCID( Chronic Exposure Estimates

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for DIFENOCONAZOLE                   (1994-98 data)

Residue file name: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 Difenoconazole 0F7785 May 2011\difenoconazole_chronic-05-11AverageFT.R98

                                                     Adjustment factor #2 used.

Analysis Date 05-10-2011/07:07:12     Residue file dated: 05-10-2011/07:03:40/8

Reference dose (RfD, Chronic) = .01 mg/kg bw/day

======================================================================== =======

                    Total exposure by population subgroup

------------------------------------------------------------------------ -------

                                                    Total Exposure

                                         -----------------------------------

          Population                         mg/kg             Percent of

           Subgroup                       body wt/day             Rfd

--------------------------------------   -------------       ---------------

U.S. Population (total)                     0.001687                16.9%

U.S. Population (spring season)             0.001678                16.8%

U.S. Population (summer season)             0.001793                17.9%

U.S. Population (autumn season)             0.001618                16.2%

U.S. Population (winter season)             0.001659                16.6%

Northeast region                            0.001620                16.2%

Midwest region                              0.001651                16.5%

Southern region                             0.001578                15.8%

Western region                              0.001956                19.6%

Hispanics                                   0.001605                16.1%

Non-hispanic whites                         0.001609                16.1%

Non-hispanic blacks                         0.001946                19.5%

Non-hisp/non-white/non-black                0.002414                24.1%

All infants (< 1 year)                      0.003001                30.0%

Nursing infants                             0.001638                16.4%

Non-nursing infants                         0.003518                35.2%

Children 1-6  yrs                           0.003782                37.8%

Children 7-12 yrs                           0.001901                19.0%

Females 13-19 (not preg or nursing)         0.001191                11.9%

Females 20+ (not preg or nursing)           0.001484                14.8%

Females 13-50 yrs                           0.001445                14.5%

Females 13+ (preg/not nursing)              0.001325                13.3%

Females 13+ (nursing)                       0.001582                15.8%

Males 13-19 yrs                             0.001419                14㈮ഥ慍敬⁳〲特⁳†††††††††††††† †⸰〰㌱㌲††††††††㌱㈮ഥ敓楮牯⁳㔵†† ††††††††††††††⸰〰㔱㜹†††††† ††㘱〮ഥ䌍楨摬敲ⴱ′特⁳†††††††††† †††〠〮㐰㜵″†††††††㐠⸵┷

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Ѐ 摧䆖Ѐ 摧獺/ᰀChildren 3-5 yrs                            0.003607                36.1%

Children 6-12 yrs                           0.002027                20.3%

Youth 13-19 yrs                             0.001307                13.1%

Adults 20-49 yrs                            0.001317                13.2%

Adults 50+ yrs                              0.001562                15.6%

Females 13-49 yrs                           0.001373                13.7%

------------------------------------------------------------------------ -------

Difenoconazole	Dietary Exposure Assessment	DP#: 389652

PC Code: 128847

  PAGE  1  of   NUMPAGES  22