2/23]

[2/24]

[0/24]

	TOTAL FETUSES WITH VISCERAL MALFORMATIONSa	5/178

4/165

1/162

2/172

TOTAL LITTERS WITH VISCERAL MALFORMATIONSa 	[5/25]

[4/23]

[1/24]

[2/24]

	TOTAL FETUSES WITH SKELETAL VARIATIONSb	39/176

29/165

42/163

42/171

TOTAL LITTERS WITH SKELETAL VARIATIONSb	[17/24]

[16/23]

[18/24]

[18/24]

	TOTAL FETUSES WITH SKELETAL MALFORMATIONS	1/176

1/165

1/163

0/171

TOTAL LITTERS WITH SKELETAL MALFORMATIONS	[1/24]

[1/23]

[1/24]

[0/24]

	EXTERNAL EXAMINATIONS

	               - TOTAL FETUSES EXAMINED:	354

329

325

343

               - TOTAL LITTERS EXAMINED:	[25]

[23]

[24]

[24]

	INDIVIDUAL EXTERNAL OBSERVATIONS

	               STUNTED  (<4.0 grams)	4

1

1

9

	[4]

[1]

[1]

[5]

INDIVIDUAL EXTERNAL MALFORMATIONS

	               CONJOINED TWIN	0

1

0

0

	[0]

[1]

[0]

[0]

	a – Includes head observations

	b – Includes calcaneus

H-1

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL EXTERNAL MALFORMATIONS (CONT'D)

	               DOMED HEAD	1

0

0

0

	[1]

[0]

[0]

[0]

	               MALROTATED HIND PAW	2

0

0

0

	[2]

[0]

[0]

[0]

VISCERAL EXAMINATIONS

	             - TOTAL FETUSES EXAMINED:	177

165

162

172

             - TOTAL LITTERS EXAMINED:	[25]

[23]

[24]

[24]

	INDIVIDUAL VISCERAL VARIATIONS

	             MISSHAPEN SPLEEN	0

1

0

0

	[0]

[1]

[0]

[0]

	             UMBILICAL ARTERY ARISES FROM LEFT SIDE OF 	4

1

3

0

             URINARY BLADDER	[3]

[1]

[2]

[0]

	INDIVIDUAL VISCERAL MALFORMATIONS

	             ATRIAL CHAMBER LARGE	0

1

0

0

	[0]

[1]

[0]

[0]

	             CECUM NOT EVIDENT	0

1

0

0

	[0]

[1]

[0]

[0]

	             DOUBLE AORTA	0

1

0

0

	[0]

[1]

[0]

[0]

H-2

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL VISCERAL MALFORMATIONS (CONT'D)

	             DUPLICATE TONGUE	0

1

0

0

	[0]

[1]

[0]

[0]

	             INNOMINATE ELONGATED	0

1

0

0

	[0]

[1]

[0]

[0]

	             INNOMINATE ABSENT	1

0

0

0

	[1]

[0]

[0]

[0]

	             HYDRONEPHROSIS	2

1

0

0

	[2]

[1]

[0]

[0]

	             HYDROURETER	2

1

0

0

	[2]

[1]

[0]

[0]

	             LUNG SUPERNUMERARY LOBE	0

1

0

0

	[0]

[1]

[0]

[0]

	             MALPOSITIONED CAROTID ARTERY	1

1

0

0

	[1]

[1]

[0]

[0]

	             MALPOSITIONED SUBCLAVIAN  ARTERY	1

1

0

0

	[1]

[1]

[0]

[0]

	             MALPOSITIONED PULMONARY ARTERY	0

1

0

0

	[0]

[1]

[0]

[0]

H-3

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL VISCERAL MALFORMATIONS (CONT'D)

	             OPEN EYE	0

0

0

1

	[0]

[0]

[0]

[1]

	             RETINA FOLD	1

0

1

0

	[1]

[0]

[1]

[0]

	             SHARED ORGANS	0

1

0

0

	[0]

[1]

[0]

[0]

	             SPLEEN SMALL	0

1

0

0

	[0]

[1]

[0]

[0]

	             UMBILICAL ARTERY ANEURYSM	0

0

0

1

	[0]

[0]

[0]

[1]

	             VENTRICLE SMALL	0

1

0

0

	[0]

[1]

[0]

[0]

SKELETAL EXAMINATIONS

	               - TOTAL FETUSES EXAMINED:	176

165

163

171

               - TOTAL LITTERS EXAMINED:	[24]

[23]

[24]

[24]

	INDIVIDUAL OSSIFICATION OBSERVATIONS

	                         CALCANEUS ADVANCED	1

0

0

0

	[1]

[0]

[0]

[0]

H-4

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL OSSIFICATION VARIATIONS

	                SKULL

	                          HYPOPLASTIC	0

1

1

0

	[0]

[1]

[1]

[0]

	                          MISSHAPEN	0

1

0

0

	[0]

[1]

[0]

[0]

               STERNEBRAE

	                         ADVANCED	1

2

2

0

	[1]

[2]

[1]

[0]

	                         ASYMMETRIC	0

2

1

2

	[0]

[2]

[1]

[1]

	                         BIFID	0

1

0

1

	[0]

[1]

[0]

[1]

	                         DUMBBELL SHAPED	0

0

0

3

	[0]

[0]

[0]

[1]

	                         HYPOPLASTIC	0

0

1

1

	[0]

[0]

[1]

[1]

	                         MISSHAPEN	4

6

2

5

	[3]

[4]

[2]

[5]

	                         UNOSSIFIED	3

0

5

 10

	[3]

[0]

[3]

[6]

H-5

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL OSSIFICATION VARIATIONS (CONT'D)

	               FOREPAW

	                         UNOSSIFIED	1

0

0

0

	[1]

[0]

[0]

[0]

               RIBS

	                         CERVICAL 	1

0

0

0

	[1]

[0]

[0]

[0]

	                         SHORT LAST THORACIC	2

0

1

0

	[2]

[0]

[1]

[0]

	                         RUDIMENTARY LUMBAR	17

15

23

24

	[9]

[10]

[13]

[13]

	                          WELL-FORMED LUMBAR	0

0

0

1

	[0]

[0]

[0]

[1]

               VERTEBRAE

	                         CENTRA BIFID	7

6

6

5

	[6]

[6]

[3]

[5]

	                         DUMBBELL-SHAPED CENTRA	3

1

3

2

	[3]

[1]

[2]

[2]

	                         CENTRA MISSHAPEN	0

0

1

0

	[0]

[0]

[1]

[0]

	                         CENTRA UNOSSIFIED	0

1

0

0

	[0]

[1]

[0]

[0]

H-6

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL OSSIFICATION VARIATIONS (CONT'D)

	               VERTEBRAE (CONT'D)

	                         LUMBAR CENTRA DUMBBELL SHAPED	1

1

1

0

	[1]

[1]

[1]

[0]

INDIVIDUAL CARTILAGINOUS STRUCTURAL VARIATIONS

	               FOREPAW ANLAGE

	                         MISSHAPEN	0

0

1

0

	[0]

[0]

[1]

[0]

               RIB ANLAGE

	                SUPERNUMERARY CERVICAL RIB	1

0

0

0

	[1]

[0]

[0]

[0]

               VERTEBRAE ANLAGE

	                         CERVICAL CENTRA BIFID	0

0

0

1

	[0]

[0]

[0]

[1]

	                         THORACIC CENTRA DUMBBELL SHAPED	12

4

9

3

	[8]

[4]

[5]

[3]

INDIVIDUAL OSSIFICATION MALFORMATIONS

	               SKULL

	                        DUPLICATE BONES	0

1

0

0

	[0]

[1]

[0]

[0]

              PECTORAL GIRDLE

	                        CLAVICLE FUSED BETWEEN TWINS	0

1

0

0

	[0]

[1]

[0]

[0]

	                        DUPLICATE BONES	0

1

0

0

	[0]

[1]

[0]

[0]

H-7

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL OSSIFICATION MALFORMATIONS (CONT'D)

              STERNEBRAE

	                        DUPLICATE BONES	0

1

0

0

	[0]

[1]

[0]

[0]

              FORELIMB

	                        DUPLICATE BONES	0

1

0

0

	[0]

[1]

[0]

[0]

	              FOREPAW

	                        DUPLICATE BONES	0

1

0

0

	[0]

[1]

[0]

[0]

	               RIBS

	                       FUSED BETWEEN TWINS	0

1

0

0

	[0]

[1]

[0]

[0]

	                         DUPLICATE BONES	0

1

0

0

	[0]

[1]

[0]

[0]

               VERTEBRAE

	                         DUPLICATE BONES	0

1

0

0

	[0]

[1]

[0]

[0]

	                         CERVICAL CENTRA FUSED	0

1

0

0

	[0]

[1]

[0]

[0]

	                         THORACIC CENTRA HEMICENTRA	0

1

0

0

	[0]

[1]

[0]

[0]

H-8

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL OSSIFICATION MALFORMATIONS (CONT'D)

VERTEBRAE (CONT'D)

	                         THORACIC ONE LESS PRESACRAL	0

0

1

0

	[0]

[0]

[1]

[0]

              PELVIC GIRDLE

	                        DUPLICATE BONES	0

1

0

0

	[0]

[1]

[0]

[0]

              HINDLIMB

	                        DUPLICATE BONES	0

1

0

0

	[0]

[1]

[0]

[0]

              HINDPAW

	                        DUPLICATE BONES	0

1

0

0

	[0]

[1]

[0]

[0]

INDIVIDUAL CARTILAGINOUS MALFORMATIONS

	               RIB ANLAGE

	                         FUSED	1

0

0

0

	[1]

[0]

[0]

[0]

H-9

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGL359F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1        A          M              +              +             +

 2        A          M              +                                            +

 3        A          M              +              +             +

 4        A          M              +                                          (c,d)

 5        A          F              +              +             +

 6        A          F              +                                            +

 7        A          F              +              +             +

 8C       A          M              +                                         (a,b,e)

 9        A          F              +              +             +

10        A          F              +                                            +

11        A          F              +              +             +

12        A          M              +                                            +

13        A          F              +              +             +

14        A          M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (V):  Unossified

(b) - SKELETAL/RIBS (T13):  Short last rib; Right

(c) - SKELETAL/VERTEBRAE (T11-12):  Bifid centra

(d) - SKELETAL/VERTEBRAE (T11-12 Anlage):  Dumbbell shaped centra

(e) - SKELETAL/VERTEBRAE (T9):  Dumbbell shaped centra

H-10

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGL360F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  3     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                          (b,c)

 2         A         F              +              +              +

 3         A         F              +                                          (b,c)

 4         A         F              +              +              +

 5         A         F              +                                            +

 6         A         F              +              +              +

 7         A         F              +                                            +

 8C        A         F              +              +              +

 9         A         M              +                                            +

10         A         M              +              +              +

11         A         M              +                                            +

12         A         F              +              +              +

13         A         M              +                                            +

 E

14         A         F              +              +              +

15         A         F              +                                           (a)

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1):  Rudimentary; Left

(b) - SKELETAL/VERTEBRAE (T10-11):  Bifid centra

(c) - SKELETAL/VERTEBRAE (T10-11 Anlage):  Dumbbell shaped centra

H-11

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGL370F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         M              +              +              +

 3         A         M              +                                            +

 4         A         F              +              +              +

 5         A         M              +                                            +

 6         A         M              +              +              +

 7         A         M              +                                            +

 8         A         M              +              +              +

 9C        A         F              +                                           (n)

10         A         F              +              +              +

11         A         F              +                                            +

12         A         M              +              +              +

13*        D         M      (A,B,C,D,E,F,G)    (H,i)        (J,K,L,M)

14         A         F              +              +              +

15         A         M              +                                           (o)

16         A         F              +              +              +

17         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

 *  - Stunted

(A) - EXTERNAL:  Kyphosis                          (L) - ABDOMEN/THORAX:  Malpositioned ovaries

(B) - EXTERNAL:  Ectrodactyly; all paws            (M) - ABDOMEN/THORAX:  No cervical spinal column

(C) - EXTERNAL:  Brachydactyly; all paws           (n) - SKELETAL/RIBS (L1):  Rudimentary; Right

(D) - EXTERNAL:  Acaudate                          (o) - SKELETAL/RIBS (L1):  Rudimentary; Left

(E) - EXTERNAL:  Anal atresia

(F) - EXTERNAL:  Anasarca

(G) - EXTERNAL:  Small eye bulge; Bilateral

(H) - HEAD:  Anophthalmia; Bilateral

(i) - HEAD:  Dilated lateral ventricles; Bilateral

(J) - ABDOMEN/THORAX:  Malpositioned uterus

(K) - ABDOMEN/THORAX:  Malpositioned kidneys

H-12

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGL374F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                          (b,c)

 2         A         M              +            (A)             +

 3         A         F              +                                            +

 4         A         M              +             +              +

 5         A         F              +                                            +

 6C        A         M              +             +              +

 7         A         F              +                                           (d)

 8         A         M              +             +              +

 9         A         F              +                                            +

 E

10         A         M              +             +              +

11         A         F              +                                            +

12         A         M              +             +              +

13         A         F              +                                            +

14         A         M              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(A) - HEAD:  Retinal fold; Left

(b) - SKELETAL/VERTEBRAE (T11):  Bifid centra

(c) - SKELETAL/VERTEBRAE (T11 Anlage):  Dumbbell shaped centra

(d) - SKELETAL/VERTEBRAE (T9):  Dumbbell shaped centra

H-13

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL395F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +             +             +

 2         A         M              +                                            +

 3         A         M              +             +             +

 4         A         M              +                                            +

 5         A         M              +             +             +

 6         A         F              +                                            +

 7         A         M              +             +             +

 8C        A         F              +                                            +

 9         A         F              +             +             +

10         A         M              +                                           (a)

11         A         M              +             +             +

12         A         M              +                                            +

13         A         M              +             +             +

14         A         M              +                                            +

15         A         F              +             +             +

16         A         M              +                                           (b)

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:  Fetus numbers 4 and 6 assigned randomly.

(a) - SKELETAL/VERTEBRAE (T11-12 Anlage): Dumbbell shaped centra

(b) - SKELETAL/VERTEBRAE (T11 Anlage):  Dumbbell shaped centra

H-14

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL383F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  1     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +             +

 2         A         F              +                                            +

 3         A         M              +              +            (a)

 4         A         M              +                                            +

 5C        A         M              +              +             +

 6         A         F              +                                            +

 7         A         F              +              +             +

 8         A         M              +                                            +

 9         A         F              +              +             +

10         A         M              +                                            +

11         A         F              +              +             +

12         A         M              +                                            +

13         A         M              +              +             +

14         A         M              +                                            +

15         A         M              +              +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - ABDOMEN/THORAX:  Umbilical artery arises from left side of urinary bladder

H-15

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGL386F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M             +                                            +

 2         A         F             +              +              +

 3         A         M             +                                          (b,c)

 4         A         M             +              +              +

 5         A         M             +                                            +

 6C        A         M             +              +              +

 7         A         M             +                                            +

 8         A         F             +              +              +

 9         A         M             +                                            +

10         A         F             +              +              +

11         A         F             +                                            +

12         A         M             +              +              +

13         A         M             +                                           (a)

14         A         M             +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (VI):  Advanced

(b) - SKELETAL/VERTEBRAE (T12):  Bifid centra

(c) - SKELETAL/VERTEBRAE (T12 Anlage):  Dumbbell shaped centra

H-16

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL394

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +(*)

 2         A         F              +             +               +

 3         A         M              +                                            +

 4         A         M              +             +               +

 5         A         M              +                                            +

 6C        A         M             (A)            +               +

 7         A         M              +                                            +

 8         A         F              +             +               +

 9         A         M              +                                            +

10         A         F              +             +               +

11         A         F              +                                           (b)

12         A         F              +             +               +

13         A         F              +                                            +

14         A         F              +             +               +

15         A         F              +                                           (b)

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(A) - EXTERNAL:  Malrotated hindpaw; Left

(b) - SKELETAL/STERNEBRAE (VI):  Misshapen

(*) - SKELETAL/HINDPAW (Calcaneus): Advanced; Bilateral

H-17

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGL402F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  4     MALFORMATIONS:  1

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         M              +             +              +

 3         A         F              +                                            +

 4         A         M              +             +              +

 5         A         F              +                                            +

 6         A         F              +             +              +

 7C        A         M              +                                           (h)

 8         A         F              +             +              +

 9         A         M              +                                           (e)

10         A         M              +             +              +

11         A         F              +                                            +

12         A         M              +             +              +

13*        A         M             (A)                                      (b,c,f,G,i)

14         A         F              +             +              +

15         A         F              +                                            +

16         A         F              +             +              +

17         A         F              +                                          (d,h)

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

 *  - Stunted

(A) - EXTERNAL:  Domed head

(b) - SKELETAL/FOREPAW (Proximal phalanges 2-4):  Unossified; Bilateral

(c) - SKELETAL/STERNEBRAE (IV-V):  Unossified

(d) - SKELETAL/STERNEBRAE (VI):  Misshapen

(e) - SKELETAL/RIBS (L1):  Rudimentary; Bilateral

(f) - SKELETAL/RIBS (C7, C7 Anlage):  Cervical rib; Bilateral

(G) - SKELETAL/RIBS (C7 and T1 Anlage):  Fused; Anlage on C7 and T1 rib fused before it meets sternebrae

(h) - SKELETAL/VERTEBRAE (T12 Anlage):  Dumbbell shaped centra

(i) - SKELETAL/VERTEBRAE (T10 Anlage):  Dumbbell shaped centra

H-18

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGL411F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +              +

 2         A         F              +                                            +

 3         A         F              +              +              +

 4         A         F              +                                            +

 5         A         F              +              +              +

 6         A         F              +                                           (b)

 7         A         F              +              +              +

 E

 8         A         M              +                                            +

 9C        A         F              +              +              +

10         A         F              +                                           (a)

11         A         M              +              +              +

12         A         M              +                                            +

13         A         M              +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (VI):  Misshapen

(b) - SKELETAL/RIBS (L1):  Rudimentary; Right

H-19

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL422F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         F              +             +              +

 3         A         M              +                                            +

 4         A         F              +             +              +

 5         A         F              +                                           (b)

 6         A         F              +             +              +

 7         A         F              +                                           (a)

 8         A         M              +             +              +

 9C        A         F              +                                            +

10         A         M              +             +              +

11         A         M              +                                            +

12         A         F              +             +              +

13         A         M              +                                            +

14         A         M              +             +              +

15         A         M              +                                            +

16         A         M              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (T13):  Short last rib; Right

(b) - SKELETAL/VERTEBRAE (T12 Anlage):  Dumbbell shaped centra

H-20

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGL347F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +             +

 2         A         F              +                                            +

 3         A         M              +              +             +

 4         A         F              +                                            +

 5         A         M              +              +             +

 6         A         F              +                                           (a)

 7         A         M              +              +             +

 8         A         F              +                                           (a)

 9C        A         F              +              +             +

10         A         M              +                                            +

11         A         F              +              +             +

12         A         M              +                                            +

13         A         F              +              +             +

14         A         M              +                                            +

15         A         F              +              +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

- SKELETAL/RIBS (L1):  Rudimentary; Left

H-21

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL427F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 E

 1C        A         F              +              +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-22

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGL400F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  3     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         F              +              +             +

 3         A         F              +                                            +

 4         A         M              +              +             +

 5         A         F              +                                           (a)

 6         A         F              +              +             +

 7         A         F              +                                           (a)

 8         A         M              +              +             +

 9         A         F              +                                           (b)

10         A         M              +              +             +

11C        A         M              +                                            +

12         A         M              +              +             +

13         A         M              +                                            +

14         A         M              +              +             +

15         A         F              +                                            +

16         A         M              +              +             +

17         A         F              +                                            +

18         A         M              +              +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1):  Rudimentary; Bilateral

(b) - SKELETAL/VERTEBRAE (T10):  Bifid centra

H-23

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGL408F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  1     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         F              +             +              +

 3         A         M              +                                            +

 4         A         M              +             +              +

 5         A         M              +                                            +

 6         A         M              +             +              +

 7         A         M              +                                            +

 8         A         F              +             +              +

 9         A         M              +                                            +

10C        A         F              +             +              +

11         A         F              +                                            +

12         A         F              +             +              +

13         A         F              +                                            +

14         A         F              +             +             (a)

15         A         F              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

- ABDOMEN/THORAX:  Umbilical artery arises from left side of urinary bladder

H-24

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL393F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +              +

 2         A         F              +                                             +

 3         A         M              +              +              +

 4C        A         M              +                                             +

 5         A         F              +              +              +

 6         A         M              +                                             +

 7         A         M              +              +              +

 8         A         F              +                                             +

 9         A         F              +              +              +

10         A         M              +                                             +

11         A         M              +              +              +

12         A         F              +                                             +

13         A         F              +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-25

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL419F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +             +

 2         A         M              +                                            +

 3         A         F              +              +             +

 4         A         M              +                                            +

 5         A         F              +              +             +

 6C        A         F              +                                            +

 7         A         F              +              +             +

 8         A         F              +                                            +

 9         A         F              +              +             +

10         A         F              +                                            +

11         A         M              +              +             +

12         A         F              +                                          (a,b)

13         A         M              +              +             +

14         A         F              +                                            +

15         A         M              +              +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T11):  Bifid centra

(b) - SKELETAL/VERTEBRAE (T11 Anlage):  Dumbbell shaped centra

H-26

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGL434F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         M              +             +               +

 3         A         M              +                                            +

 4         A         M              +             +               +

 5         A         M              +                                            +

 6         A         M              +             +               +

 7         A         M              +                                            +

 8         A         M              +             +               +

 9         A         F              +                                            +

10C        A         M              +             +               +

11         A         M              +                                            +

12         A         M              +             +             (A,B)

13         A         F              +                                            +

 L

14         A         F              +             +               +

15         A         F              +                                            +

16         A         F              +             +               +

17         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(A) - ABDOMEN/THORAX:  Hydroureter; Bilateral

(B) - ABDOMEN/THORAX:  Hydronephrosis; Bilateral

H-27

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL445F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +              +

 2         A         M              +                                             +

 3         A         M              +             +              +

 4         A         M              +                                             +

 5*        A         M              +             +              +

 6C        A         M              +                                             +

 7         A         M              +             +              +

 8         A         M              +                                             +

 9         A         F              +             +              +

10         A         F              +                                             +

11         A         F              +             +              +

12         A         F              +                                             +

13         A         F              +             +              +

14         A         F              +                                             +

15         A         F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

 *  - Stunted

H-28

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL446F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  2     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         F              +             +              +

 3         A         M              +                                            +

 4         A         F              +             +            (a,B,C)

 5         A         M              +                                            +

 6         A         M              +             +              +

 E

 7         A         F              +                                            +

 8C        A         M              +             +             (a)

 9         A         F              +                                            +

10         A         M              +             +              +

11         A         F              +                                           (d)

12         A         F              +             +              +

 E

13         A         M              +                                            +

14         A         F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - ABDOMEN/THORAX:  Umbilical artery arises from left side of urinary bladder

(B) - ABDOMEN/THORAX:  Hydroureter; Left

(C) - ABDOMEN/THORAX:  Hydronephrosis; Left

(d) - SKELETAL/STERNEBRAE (V):  Unossified

H-29

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL465F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +              +

 2         A         F              +                                            +

 3         A         F              +             +              +

 4         A         F              +                                            +

 5         A         M              +             +              +

 6         A         M              +                                            +

 7         A         F              +             +              +

 8C        A         F             (A)                                           +

 9         A         M              +             +              +

10         A         F              +                                            +

11         A         F              +             +              +

12         A         M              +                                            +

13         A         M              +             +              +

14         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

- EXTERNAL:  Malrotated hind paw; Left

H-30

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  0 MG/M3

ANIMAL NUMBER:  IGL490F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  3     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         M              +              +            +

 3         A         M              +                                           (e)

 4         A         F              +              +            +

 5         A         M              +                                           (e)

 6         A         F              +              +            +

 7         A         M              +                                            +

 8*        A         F              +              +         (A,B,C,D)

 9C        A         F              +                                            +

10         A         F              +              +            +

11         A         M              +                                           (e)

12         A         M              +              +            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

 *  - Stunted

(A) - ABDOMEN/THORAX:  Innominate artery absent

(B) - ABDOMEN/THORAX:  Malpositioned carotid branch; Left

(C) - ABDOMEN/THORAX:  Malpositioned carotid branch; Right

(D) - ABDOMEN/THORAX:  Malpositioned subclavian branch; Right

(e) - SKELETAL/RIBS (L1):  Rudimentary; Left

H-31

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL406F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                             +

 2         A         F              +             +               +

 3         A         F              +                                             +

 4         A         F              +             +               +

 5C        A         M              +                                             +

 6         A         M              +             +               +

 7         A         M              +                                             +

 8         A         M              +             +               +

 9         A         M              +                                             +

 E

10         A         F              +             +               +

11         A         F              +                                             +

12         A         F              +             +               +

13         A         M              +                                             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-32

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL418F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  4     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                           (a)

 2         A         F              +             +              +

 3         A         F              +                                          (b,d)

 E

 4         A         F              +             +              +

 5         A         M              +                                           (c)

 6C        A         M              +             +              +

 7         A         F              +                                            +

 8         A         M              +             +              +

 9         A         M              +                                           (a)

10         A         M              +             +              +

11         A         F              +                                            +

12         A         M              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

(b) - SKELETAL/RIBS (L1): Rudimentary; Left

(c) - SKELETAL/RIBS (L1): Rudimentary; Right

(d) - SKELETAL/VERTEBRAE (L1): Dumbbell shaped centra; Left

H-33

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    0 MG/M3

ANIMAL NUMBER:  IGL474F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         F              +             +              +

 3         A         F              +                                           (a)

 4         A         F              +             +              +

 5         A         F              +                                            +

 E

 6C        A         F              +             +              +

 7         A         M              +                                            +

 8         A         M              +             +              +

 9         A         M              +                                            +

10         A         F              +             +              +

11         A         F              +                                            +

12         A         M              +             +              +

13         A         M              +                                            +

14         A         F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

- SKELETAL/RIBS (L1): Rudimentary; Left

H-34

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL346F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         M              +             +              +

 3         A         M              +                                            +

 4         A         F              +             +              +

 5         A         F              +                                            +

 6         A         F              +             +              +

 7C        A         M              +                                            +

 8         A         F              +             +              +

 9         A         F              +                                            +

10         A         M              +             +              +

11         A         F              +                                            +

12         A         M              +             +              +

13         A         M              +                                            +

14         A         F              +             +              +

15         A         F              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-35

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL361F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +             +             +

 2         A         F              +                                            +

 3         A         F              +             +             +

 4         A         F              +                                            +

 5         A         M              +             +             +

 6C        A         F              +                                            +

 7         A         F              +             +             +

 8         A         M              +                                          (a,b)

 9         A         F              +             +             +

10         A         M              +                                            +

11         A         M              +             +             +

12         A         F              +                                            +

13         A         M              +             +             +

14         A         M              +                                            +

15         A         F              +             +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (VI):  Advanced

(b) - SKELETAL/RIBS (L1): Rudimentary; Left

H-36

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    2000 MG/M3

ANIMAL NUMBER:  IGL376F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  1     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         F              +             +            (a)

 3         A         M              +                                            +

 4         A         F              +             +             +

 5         A         F              +                                            +

 6         A         F              +             +             +

 7         A         M              +                                            +

 8C        A         M              +             +             +

 9         A         F              +                                            +

10         A         M              +             +             +

11         A         F              +                                            +

12         A         M              +             +             +

13         A         M              +                                            +

 E

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - ABDOMEN/THORAX:  Umbilical artery arises from left side of urinary bladder

H-37

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL381F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 E

 1         A         F              +                                            +

 2         A         M              +             +              +

 3         A         M              +             +              +

 4         A         F              +                                            +

 5         A         F              +             +              +

 E

 6         A         M              +                                          (a,b)

 E

 7         A         F              +             +              +

 8         A         F              +                                            +

 9C        A         M              +             +              +

 E

10         A         F              +                                            +

 E

11         A         F              +             +              +

 E

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE: Fetus # 1 inadvertently eviscerated, therefore fetus # 1 received a skeletal exam and fetus # 2 received a visceral and head exam.

(a) - SKELETAL/VERTEBRAE (T10):  Bifid centra

(b) - SKELETAL/VERTEBRAE (T10 Anlage):  Dumbbell shaped centra

H-38

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL405F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +               +

 2         A         F              +                                             +

 3         A         F              +             +               +

 4         A         M              +                                             +

 5         A         M              +             +               +

 6         A         F              +                                             +

 7         A         F              +             +               +

 8         A         F              +                                             +

 9         A         M              +             +               +

10C        A         F              +                                             +

11         A         M              +             +               +

12         A         M              +                                             +

13         A         M              +             +               +

14         A         M              +                                             +

15         A         F              +             +               +

16         A         M              +                                             +

17         A         F              +             +               +

18         A         M              +                                             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-39

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL382F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         F              +             +              +

 3         A         F              +                                            +

 4         A         F              +             +              +

 5         A         M              +                                           (a)

 6         A         M              +             +              +

 7C        A         F              +                                            +

 8         A         F              +             +              +

 9         A         F              +                                            +

10         A         M              +             +              +

11         A         M              +                                            +

12         A         F              +             +              +

13         A         F              +                                            +

14         A         M              +             +              +

15         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (VI):  Misshapen

H-40

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL390F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         F              +              +              +

 3         A         F              +                                           (a)

 4         A         M              +              +              +

 5         A         M              +                                            +

 6C        A         F              +              +              +

 7         A         F              +                                            +

 8         A         M              +              +              +

 9         A         F              +                                            +

10         A         F              +              +              +

 E

11         A         F              +                                            +

12         A         F              +              +              +

13         A         F              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T11):  Bifid centra

H-41

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    2000 MG/M3

ANIMAL NUMBER:  IGL358F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         M              +             +              +

 3         A         M              +                                            +

 4         A         F              +             +              +

 5         A         M              +                                            +

 6         A         F              +             +              +

 7         A         M              +                                            +

 8         A         M              +             +              +

 9C        A         M              +                                            +

10         A         M              +             +              +

11         A         F              +                                            +

12         A         M              +             +              +

13         A         M              +                                            +

14         A         F              +             +              +

15         A         M              +                                            +

16         A         F              +             +              +

17         A         F              +                                            +

18         A         F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-42

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    2000 MG/M3

ANIMAL NUMBER:  IGL398F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         M              +             +              +

 3         A         M              +                                            +

 4         A         F              +             +              +

 5         A         M              +                                            +

 6         A         F              +             +              +

 7         A         F              +                                            +

 8C        A         M              +             +              +

 9         A         F              +                                            +

10         A         M              +             +              +

11         A         M              +                                           (a)

12         A         M              +             +              +

13         A         M              +                                            +

14         A         M              +             +              +

15         A         F              +                                            +

16         A         F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1):  Rudimentary; Left

H-43

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    2000 MG/M3

ANIMAL NUMBER:  IGL350F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         F              +             +              +

 3         A         F              +                                            +

 4         A         F              +             +              +

 5         A         M              +                                            +

 6         A         M              +             +              +

 7         A         M              +                                            +

 8C        A         M              +             +              +

 9         A         F              +                                            +

10         A         F              +             +              +

11         A         M              +                                            +

12         A         F              +             +              +

13         A         F              +                                            +

14         A         M              +             +              +

15         A         M              +                                            +

16         A         F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-44

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL353F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  5     MALFORMATIONS:  1

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +             +

 2         A         M             (A)                       (B-K,*)   (L,N,O,P,Q,R,s,t,u,W,X,z)

(AA,BB,cc,DD,ee,FF,GG,HH)

 3         A         F              +             +             +

 4         A         F              +                                         (m,y)

 5         A         M              +             +             +

 6         A         M              +                                          (v)

 7         A         F              +             +             +

 8         A         F              +                                           +

 9         A         F              +             +             +

10C        A         M              +                                          (v)

11         A         F              +             +             +

12         A         M              +                                          (v)

13         A         M              +             +             +

14         A         F              +                                           +

15         A         F              +             +             +

16         A         F              +                                           +

17         A         F              +             +             +

18         A         M              +                                           +

19         A         F              +             +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

                                NOTE:

                                (A) - EXTERNAL:  Conjoined twin; Joined at thoracic region; 1 head, 8 limbs, 2 tails, 1 umbilicus

(B) - ABDOMEN/THORAX:  Liver, stomach, spleen, entire small intestine shared

(C) - ABDOMEN/THORAX:  Spleen small

(D) - ABDOMEN/THORAX:  Cecum not evident; bifurcation appears in area where cecum would normally reside

(E) - ABDOMEN/THORAX:  All thoracic and cranial organs shared

(F) - ABDOMEN/THORAX:  Supernumerary lung lobe; Left

(G) - ABDOMEN/THORAX:  Double aorta

(H) - ABDOMEN/THORAX:  Malpositioned carotid and subclavian branches; Bilateral

(I) - ABDOMEN/THORAX:  Malpositioned pulmonary artery branch

(J) - ABDOMEN/THORAX:  Ventricle small; Left

(K) - ABDOMEN/THORAX:  Duplicate tongue

(*) - ABDOMEN/THORAX:  All other abdominal organs appear on each side

H-45

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL353F (cont'd)

(L) -  SKELETAL/SKULL (Supraoccipital,Interparietal,Parietals,Frontals,Nasals):  Duplication or extra bones

(m) -  SKELETAL/SKULL (Interparietal):  Misshapen

(N) -  SKELETAL/PECTORAL GIRDLE (Clavicle):  Right side of left twin fused to left side of right twin

(O) -  SKELETAL/PECTORAL GIRDLE (All bones):  Duplication or extra bones; Bilateral

(P) -  SKELETAL/FORELIMB (All bones ):  Duplication or extra bones

(Q) -  SKELETAL/FOREPAW (All bones):  Duplication or extra bones

(R) -  SKELETAL/STERNEBRAE (All bones):  Duplication or extra bones

(s) -  SKELETAL/STERNEBRAE (Left twin III):  Misshapen

(t) -  SKELETAL/STERNEBRAE (Left twin IV):  Bifid

(u) -  SKELETAL/STERNEBRAE (Right twin I,IV):  Asymmetric form

(v) -  SKELETAL/STERNEBRAE (VI):  Misshapen

(W) -  SKELETAL/RIBS (All bones): Duplication or extra bones

(X) -  SKELETAL/RIBS (Right twin T8 left, Left twin T8 right):  Fused; Left

(y) -  SKELETAL/RIBS  (L1):  Rudimentary; Right

(z) -  SKELETAL/RIBS (Left twin L1):  Rudimentary; Right

(AA) - SKELETAL/VERTEBRAE (All bones):  Duplication or extra bones

(BB) - SKELETAL/VERTEBRAE (Left twin CE 1-7):  Fused

(cc) - SKELETAL/VERTEBRAE (Left twin T2):  Unossified centra

(DD) - SKELETAL/VERTEBRAE (Left twin T3):  Hemicentra

(ee) - SKELETAL/VERTEBRAE (Left twin T11):  Bifid centra

(FF) - SKELETAL/PELVIC GIRDLE (All bones):  Duplication or extra bones; Bilateral

(GG) - SKELETAL/HINDLIMB (All bones):  Duplication or extra bones; Bilateral

(HH) - SKELETAL/HINDPAW (All bones):  Duplication or extra bones; Bilateral

H-46

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL420F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         M              +              +             +

 3         A         F              +                                            +

 4         A         F              +              +             +

 E

 5         A         M              +                                            +

 6         A         M              +              +             +

 7         A         M              +                                            +

 8C        A         M              +              +             +

 9         A         F              +                                            +

10         A         F              +              +             +

11         A         F              +                                            +

12         A         F              +              +             +

13         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-47

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL388F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         F              +             +              +

 3         A         M              +                                           (a)

 4         A         F              +             +              +

 5         A         F              +                                            +

 6         A         F              +             +              +

 7         A         F              +                                            +

 8C        A         F              +             +              +

 9         A         F              +                                            +

10         A         F              +             +              +

11         A         F              +                                            +

12         A         F              +             +              +

13         A         M              +                                            +

14         A         F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Right

H-48

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    2000 MG/M3

ANIMAL NUMBER:  IGL413F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +            +

 2         A         F              +                                            (b)

 3         A         M              +              +            +

 4         A         M              +                                            (a)

 5         A         M              +              +            +

 6         A         M              +                                             +

 7         A         M              +              +            +

 8         A         M              +                                             +

 9C        A         F              +              +            +

10         A         F              +                                             +

11         A         M              +              +            +

12         A         F              +                                             +

13         A         F              +              +            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1):  Rudimentary; Bilateral

(b) - SKELETAL/VERTEBRAE (T11):  Bifid centra

H-49

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL414F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         M              +              +             +

 3         A         M              +                                            +

 4         A         F              +              +             +

 5         A         M              +                                          (a,b)

 6         A         M              +              +             +

 7         A         M              +                                            +

 8         A         F              +              +             +

 9C        A         F              +                                            +

10         A         F              +              +             +

11         A         M              +                                            +

12         A         F              +              +             +

 E

 E

13         A         M              +                                            +

14         A         F              +              +             +

15         A         F              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1):  Rudimentary; Left

(b) - SKELETAL/VERTEBRAE (L1):  Dumbbell shaped centra

H-50

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    2000 MG/M3

ANIMAL NUMBER:  IGL433F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  5     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1*        A         F              +              +           (A)

 2         A         F              +                                            (b)

 3         A         M              +              +            +

 4         A         F              +                                            (e)

 5         A         F              +              +            +

 6         A         M              +                                             +

 7         A         F              +              +            +

 8         A         F              +                                             +

 9         A         F              +              +            +

10         A         F              +                                             +

11C        A         F              +              +            +

12         A         F              +                                            (c)

13         A         M              +              +            +

14         A         F              +                                            (c)

15         A         F              +              +            +

16         A         F              +                                            (d)

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

 *  - Stunted

(A) - ABDOMEN/THORAX:  Enlarged atrial chamber; Right

(b) - SKELETAL/STERNEBRAE (VI):  Misshapen

(c) - SKELETAL/RIBS (L1):  Rudimentary; Left

(d) - SKELETAL/RIBS (L1):  Rudimentary; Bilateral

(e) - SKELETAL/VERTEBRAE (T11 Anlage):  Dumbbell shaped centra

H-51

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL441F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +              +

 2         A         M              +                                           (a)

 3         A         M              +             +              +

 E

 4         A         F              +                                            +

 5         A         M              +             +              +

 6         A         F              +                                            +

 7         A         M              +             +              +

 8         A         M              +                                            +

 9C        A         M              +             +              +

10         A         M              +                                           (b)

11         A         F              +             +              +

12         A         F              +                                            +

13         A         F              +             +              +

14         A         M              +                                            +

15         A         F              +             +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (VI):  Advanced

(b) - SKELETAL/STERNEBRAE (IV):  Asymmetric form

H-52

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    2000 MG/M3

ANIMAL NUMBER:  IGL457F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  3     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +              +

 2         A         F              +                                            (a)

 3         A         M              +             +              +

 4         A         M              +                                            (b)

 5         A         F              +             +              +

 6         A         M              +                                             +

 7         A         M              +             +              +

 8C        A         M              +                                             +

 9         A         M              +             +              +

10         A         F              +                                            (a)

 E

11         A         F              +             +              +

12         A         F              +                                             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

(b) - SKELETAL/RIBS (L1): Rudimentary; Right

H-53

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL466F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         M              +              +              +

 3         A         M              +                                            +

 4         A         M              +              +              +

 5         A         F              +                                            +

 6         A         M              +              +              +

 7C        A         F              +                                            +

 8         A         F              +              +              +

 9         A         F              +                                            +

10         A         F              +              +              +

11         A         M              +                                           (a)

 E

12         A         M              +              +              +

13         A         M              +                                            +

14         A         F              +              +              +

15         A         M              +                                            +

16         A         F              +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Right

H-54

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL475F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1C        A         F              +             +              +

 2         A         F              +                                           (a,b)

 3         A         M              +             +              +

 4         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T11):  Bifid centra

(b) - SKELETAL/VERTEBRAE (T11 Anlage):  Dumbbell shaped centra

H-55

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    2000 MG/M3

ANIMAL NUMBER:  IGL488F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                             +

 2         A         F              +              +              +

 3C        A         F              +                                             +

 4         A         M              +              +              +

 5         A         M              +                                             +

 6         A         F              +              +              +

 7         A         M              +                                             +

 8         A         F              +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-56

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL432F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                            +

 2         A         M              +             +                +

 3         A         F              +                                            +

 4         A         M              +             +                +

 5         A         F              +                                           (b)

 6         A         F              +             +                +

 7         A         M              +                                            +

 8         A         M              +             +                +

 9C        A         M              +                                            +

10         A         M              +             +                +

11         A         M              +                                            +

12         A         F              +             +                +

13         A         M              +                                            +

14         A         F              +             +               (A)

15         A         F              +                                            +

16         A         M              +             +                +

17         A         F              +                                           (c)

18         A         M              +             +                +

19         A         M              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(A) - ABDOMEN/THORAX:  Elongated innominate artery

(b) - SKELETAL/SKULL (Squamosal Process):  Hypoplastic; Left

(c) - SKELETAL/RIBS (L1):  Rudimentary; Right

H-57

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  2000 MG/M3

ANIMAL NUMBER:  IGL477F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  1     MALFORMATIONS:  1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +             +                 (a)

 2         A         F              +                                             +

 3         A         F              +             +                  +

 4         A         M              +                                             +

 5C        A         F              +             +                  +

 6         A         F              +                                           (d,e)

 7         A         M              +             +                  +

 8         A         F              +                                             +

 9         A         M              +             +                (B,C)

10         A         M              +                                             +

11         A         F              +             +                  +

12         A         F              +                                             +

13         A         F              +             +                  +

14         A         M              +                                             +

15         A         M              +             +                  +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - ABDOMEN/THORAX:  Misshapen spleen

(B) - ABDOMEN/THORAX:  Hydroureter; Left

(C) - ABDOMEN/THORAX:  Hydronephrosis; Left

(d) - SKELETAL/VERTEBRAE (T11):  Bifid centra

(e) - SKELETAL/VERTEBRAE (T11 Anlage):  Dumbbell shaped centra

H-58

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    10000 MG/M3

ANIMAL NUMBER:  IGL379F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  3     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +              +             +

 2         A         F              +                                           (a)

 3         A         M              +              +             +

 4C        A         F              +                                            +

 5         A         M              +              +             +

 6         A         F              +                                           (a)

 7         A         M              +              +             +

 8         A         F              +                                           (b)

 9         A         M              +              +             +

10         A         M              +                                            +

11         A         M              +              +             +

12         A         F              +                                            +

13         A         F              +              +             +

14         A         M              +                                            +

15         A         F              +              +             +

16         A         F              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1):  Rudimentary; Left

(b) - SKELETAL/RIBS (L1):  Rudimentary; Bilateral

H-59

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    10000 MG/M3

ANIMAL NUMBER:  IGL389F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  0     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +             +               +

 2         A         F              +                                             +

 3         A         F              +             +               +

 4         A         F              +                                             +

 5         A         M              +             +               +

 6         A         F              +                                             +

 7         A         M              +             +               +

 8         A         M              +                                             +

 9C        A         M              +             +               +

10         A         M              +                                             +

11         A         M              +             +               +

12         A         M              +                                             +

13         A         M              +             +               +

14         A         F              +                                             +

15         A         F              +             +               +

16         A         M              +                                             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

H-60

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGL391F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +              +              +

 2         A         M              +                                            +

 3         A         F              +              +              +

 E

 4         A         M              +                                            +

 5         A         F              +              +              +

 E

 6         A         M              +                                            +

 7C        A         F              +              +              +

 8         A         M              +                                            +

 9         A         M              +              +              +

10         A         M              +                                            +

11         A         M              +              +              +

12         A         F              +                                            +

13         A         F              +              +              +

14         A         F              +                                           (a)

15         A         F              +              +              +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (V):  Unossified

H-61

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    10000 MG/M3

ANIMAL NUMBER:  IGL352F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +                                            +

 2         A         F              +             +             +

 3         A         M              +                                           (b)

 4         A         F              +             +             +

 5         A         F              +                                            +

 6         A         F              +             +             +

 7C        A         M              +                                            +

 8         A         F              +             +             +

 9         A         M              +                                           (a)

 E

10         A         F              +             +             +

11         A         M              +                                            +

12         A         M              +             +             +

13         A         F              +                                            +

14         A         M              +             +             +

 E

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/SKULL (Tympanics):  Hypoplastic

(b) - SKELETAL/RIBS (L1):  Rudimentary; Left

H-62

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    10000 MG/M3

ANIMAL NUMBER:  IGL355F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  7     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +              +             +

 2         A         M              +                                          (c,e,f)

 3         A         M              +              +             +

 4         A         F              +                                            (c)

 5         A         F              +              +             +

 6         A         M              +                                        (a,d,g,h,i)

 7         A         M              +              +             +

 8         A         F              +                                            (c)

 9C        A         F              +              +             +

10*        A         M              +                                            (a)

11         A         F              +              +             +

12         A         F              +                                            (a)

13         A         M              +              +             +

14         A         M              +                                             +

15         A         F              +              +             +

16         A         F              +                                            (b)

17         A         M              +              +             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

 *  - Stunted

(a) - SKELETAL/STERNEBRAE (V):  Unossified

(b) - SKELETAL/STERNEBRAE (III-IV):  Asymmetric form

(c) - SKELETAL/RIBS (L1):  Rudimentary; Left

(d) - SKELETAL/RIBS (L1):  Rudimentary; Bilateral

(e) - SKELETAL/VERTEBRAE (T13):  Bifid centra

(f) - SKELETAL/VERTEBRAE (T13 Anlage):  Dumbbell shaped centra

(g) - SKELETAL/VERTEBRAE (T11):  Bifid centra

(h) - SKELETAL/VERTEBRAE (T11 Anlage):  Dumbbell shaped centra

(i) - SKELETAL/VERTEBRAE (L1):  Misshapen centra

H-63

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGL417F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         M              +             +            +

 2         A         M              +                                            (a)

 3         A         M              +             +            +

 4         A         F              +                                            (b)

 5         A         F              +             +            +

 6         A         M              +                                             +

 7C        A         M              +             +            +

 8         A         M              +                                             +

 9         A         M              +             +            +

10         A         M              +                                             +

11         A         M              +             +            +

12         A         F              +                                             +

13         A         M              +             +            +

14         A         F              +                                             +

15         A         F              +             +            +

16         A         M              +                                             +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

(b) - SKELETAL/RIBS (L1): Rudimentary; Left

H-64

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:    10000 MG/M3

ANIMAL NUMBER:  IGL378F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  1     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 L

 1         A         M              +                                           (a)

 2         A         M              +             +              +

 3         A         F              +                                            +

 4         A         F              +             +              +

 5         A         M              +                                            +

 6         A         F              +             +              +

 7C        A         F              +                                            +

 8         A         M              +             +              +

 9         A         M              +                                            +

10         A         M              +             +              +

11         A         M              +                                            +

12         A         M              +             +              +

 E

13         A         F              +                                            +

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1):  Rudimentary; Right

H-65

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS

(ABBREVIATIONS PRESENTED BELOW OBSERVATIONS)

TARGET DOSE:  10000 MG/M3

ANIMAL NUMBER:  IGL380F

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH VISCERAL VARIATIONS:  0     MALFORMATIONS:  0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:  2     MALFORMATIONS:  0

FETUS | STATUS |    SEX    |     EXTERNAL     |          VISCERAL          |  SKELETAL  |

 NO.  |        |           |                  |  HEAD  |   ABDOMEN/THORAX  |            |

------|--------|-----------|------------------|--------|---------------- ---|------------|

 1         A         F              +                                             +

 2         A         M              +             +                +

 3         A         F              +                                             +

 4         A         M              +             +                +

 5         A         M              +                                            (a)

 6         A         M              +             +                +

 7C        A         F              +                                             +

 8         A         M              +             +                +

 9         A         F              +                                             +

10         A         M              +             +                +

11         A         M              +                                             +

12         A         F              +             +                +

13         A         M              +                                             +

14         A         M              +             +                +

15         A         F              +                                            (a)

A = ALIVE      M = MALE      E = EARLY RESORPTION      C = CERVIX

D = DEAD       F = FEMALE    L = LATE RESORPTION       + = NO OBSERVABLE ABNORMALITIES

NOTE:

- SKELETAL/STERNEBRAE (VI): Advanced

H-66

APPENDIX H - INDIVIDUAL FETAL OBSERVATIONS