Honeybees could potentially be exposed to pesticide residues if treated wood is used to construct hives or hive components. These residues may be toxic to the bees or result in residues in honey or other hive products intended for human use/ consumption. Therefore, a special honeybee study is required for all wood preservative uses unless a statement prohibiting the use of treated wood in hive construction is added to the label such as, " Wood treated with TCMTB shall not be used in the construction of beehives." This study is a combination of Guidelines 171 4 and 850.3030 ( see information regarding residue data requirements for uses in beehives in the residue chemistry section of 40 CFR part 158). Numbers of bees used in this study and methods for collection/ introduction of bees into hives, feeding, and observations for toxicity and mortality should be consistent with those described in OPPTS Guideline 850.3030, " Honey Bee Toxicity of Residues on Foliage." The toxicity portion of this study is in lieu of the honeybee contact LD50 test. 47 c. Risk to Listed Species Section 7 of the Endangered Species Act, 16 U. S. C. Section 1536( a)( 2), requires all federal agencies to consult with the National Marine Fisheries Service ( NMFS) for marine and anadromous listed species, or the United States Fish and Wildlife Services ( FWS) for listed wildlife and freshwater organisms, if they are proposing an " action" that may affect listed species or their designated habitat. Each federal agency is required under the Act to insure that any action they authorize, fund, or carry out is not likely to jeopardize the continued existence of a listed species or result in the destruction or adverse modification of designated critical habitat. To jeopardize the continued existence of a listed species means " to engage in an action that reasonably would be expected, directly or indirectly, to reduce appreciably the likelihood of both the survival and recovery of a listed species in the wild by reducing the reproduction, numbers, or distribution of the species" ( 50 C. F. R. ' 402.02).

To facilitate compliance with the requirements of the Endangered Species Act subsection ( a)( 2) the Environmental Protection Agency, Office of Pesticide Programs has established procedures to evaluate whether a proposed registration action may directly or indirectly reduce appreciably the likelihood of both the survival and recovery of a listed species in the wild by reducing the reproduction, numbers, or distribution of any listed species ( U. S. EPA 2004). After the Agency's screening level risk assessment is performed, if any of the Agency's Listed Species LOC Criteria are exceeded for either direct or indirect effects, a determination is made to identify if any listed or candidate species may co occur in the area of the proposed pesticide use. If determined that listed or candidate species may be present in the proposed use areas, further biological assessment is undertaken. The extent to which listed species may be at risk then determines the need for the development of a more comprehensive consultation package as required by the Endangered Species Act.

For certain use categories, the Agency assumes there will be minimal environmental exposure, and only a minimal toxicity data set is required ( Overview of the Ecological Risk Assessment Process in the Office of Pesticide Programs U. S. Environmental Protection Agency  Endangered and Threatened Species Effects Determinations, 1/ 23/ 04, Appendix A, Section IIB, pg. 81). Chemicals in these categories therefore do not undergo a full screening level risk assessment, and are considered to fall under a no effect determination. The active ingredient uses of TCMTB, with the exception of the seed treatment and antisapstain wood preservation uses, fall into this category. Using Tier I screening modeling to assess potential exposure from seed treatment risks to Listed Species were not identified. Using Tier I screening modeling to assess potential exposure from antisapstain wood preservation uses of TCMTB, risks to Listed Species are indicated. Since the model is only intended as a screening level model, and, as such, has inherent uncertainties and limitations which may result in inaccurate exposure estimations, further refinement of the model is recommended before any regulatory action is taken regarding the antisapstain uses of TCMTB. Additionally, impacts from the antisapstain use could potentially be mitigated with precautions to prevent leaching and runoff when wood is stored outdoors ( see General Risk Mitigation, below). Due to these circumstances, the Agency defers making a determination for the antisapstain uses of TCMTB until additional data and modeling 48 refinements are available. At that time, the environmental exposure assessment of the antisapstain use of TCMTB will be revised, and the risks to Listed Species will be reconsidered. 49 IV. Risk Management, Reregistration, and Tolerance Reassessment Decision A. Determination of Reregistration Eligibility Section 4( g)( 2)( A) of FIFRA calls for the Agency to determine, after submission of relevant data concerning an active ingredient, whether or not products containing the active ingredient are eligible for reregistration. The Agency has previously identified and required the submission of the generic ( i. e., active ingredient specific) data required to support reregistration of products containing TCMTB as an active ingredient. The Agency has completed its review of these generic data and has determined that the data are sufficient to support reregistration of all supported products containing TCMTB.

The Agency has completed its assessment of the dietary, occupational, drinking water, and ecological risks associated with the use of pesticide products containing the active ingredient TCMTB. Based on a review of these data and on public comments on the Agency's assessments for the active ingredient TCMTB, the Agency has sufficient information on the human health and ecological effects of TCMTB to make decisions as part of the tolerance reassessment process under FFDCA and reregistration process under FIFRA, as amended by FQPA. The Agency has determined that TCMTB containing products are eligible for reregistration provided that: ( i) current data gaps and confirmatory data needs are addressed; ( ii) the risk mitigation measure outlined in this document is adopted; and ( iii) label amendments are made to reflect this measure. Label changes are described in Section V. Appendix A summarizes the uses of TCMTB that are eligible for reregistration. Appendix B identifies the generic data requirements that the Agency reviewed as part of its determination of reregistration eligibility of TCMTB and lists the submitted studies that the Agency found acceptable. Data gaps are identified as generic data requirements that have not been satisfied with acceptable data.

Based on its evaluation of TCMTB, the Agency has determined that TCMTB products, unless labeled and used as specified in this document, would present risks inconsistent with FIFRA. Accordingly, should a registrant fail to implement the risk mitigation measure identified in this document, the Agency may take regulatory action to address the risk concerns from the use of TCMTB. If all changes outlined in this document are incorporated into the product labels, then all current risks for TCMTB will be substantially mitigated for the purposes of this determination. Once an Endangered Species assessment is completed, further changes to these registrations may be necessary as explained in Section III of this document.

B. Public Comments and Responses Through the Agency's public participation process, the EPA worked with stakeholders and the public to reach the regulatory decision for TCMTB. EPA released its preliminary risk assessment for TCMTB for public comment on April 26, 2006. The Agency received no comments during the 60 day public comment period on the TCMTB risk assessment and supporting science documents, which closed on June 26, 2006. 50 C. Regulatory Position 1. Food Quality Protection Act Findings a. " Risk Cup" Determination As part of the FQPA tolerance reassessment process, EPA assessed the risks associated with TCMTB use. The Agency has determined that, if the mitigation described in this document is adopted and labels are amended, human health risks as a result of exposures to TCMTB are within acceptable levels. In other words, EPA has concluded that the tolerances for TCMTB meet FQPA safety standards. In reaching this determination, EPA has considered the available information on the special sensitivity of infants and children, as well as exposures to TCMTB from all possible sources.

b. Determination of Safety to U. S. Population As part of the FQPA tolerance reassessment process, EPA assessed the risks associated with TCMTB. The Agency has determined that the tolerances for TCMTB, with amendments and changes specified in this document, meet the safety standards under the FQPA amendments to section 408( b)( 2)( D) of the FFDCA, and that there is a reasonable certainty no harm will result to the general population or any subgroup from the use of TCMTB. In reaching this conclusion, the Agency has considered all available information on the toxicity, use practices and exposure scenarios, and the environmental behavior of TCMTB.

Dietary risk assessments were conducted for adults and children, with the highest risks ( children at 2% aPAD for seed treatment use and children at 0.66% aPAD for antimicrobial use; children at 17% of cPAD for seed treatment use and children at 12.8% cPAD) being below the Agency's level of concern.

The Agency conducted acute and chronic aggregate assessments that considered food and drinking water exposures from the registered agricultural and antimicrobial uses of TCMTB. The residential uses of TCMTB were not included in the aggregate assessment because all of the residential uses evaluated have risks of concern ( MOEs < 100). Thus, the short and intermediate term aggregate assessment that included the residential uses would also show risks of concern.

The subpopulation with the greatest risk for both the acute and chronic aggregate risk assessments was children ( 2.5% of aPAD for children and 40% of cPAD for children). These risk estimates are below the Agency's level of concern.

c. Determination of Safety to Infants and Children EPA has determined that the currently registered uses of TCMTB, with changes as specified in this document, meet the safety standards under the FQPA amendments to section 408( b)( 2)( C) of the FFDCA, that there is a reasonable certainty of no harm for infants and children. The safety determination for infants and children considers factors of the toxicity, use 51 practices, and environmental behavior noted above for the general population, but also takes into account the possibility of increased susceptibility to the toxic effects of TCMTB residues in this population subgroup.

No Special FQPA Safety Factor is necessary to protect the safety of infants and children. In determining whether or not infants and children are particularly susceptible to toxic effects from TCMTB residues, the Agency considered the completeness of the database for developmental and reproductive effects, the nature of the effects observed, and other information. The FQPA Safety Factor has been removed ( i. e., reduced to 1X) for TCMTB based on: ( 1) the toxicology database is complete with respect to assessing the increased susceptibility to infants and children as required by FQPA; ( 2) there is no concern for developmental neurotoxicity resulting from exposure to TCMTB in the rat and rabbit prenatal developmental studies and the 2 generation reproduction study; ( 3) there is no evidence of increased susceptibility to the fetus following in utero exposure in the prenatal developmental toxicity studies or to the offspring when adults are exposed in the two generation reproductive study; and ( 4) the risk assessment does not underestimate the potential exposure for infants and children.

d. Endocrine Disruptor Effects EPA is required under the FFDCA, as amended by FQPA, to develop a screening program to determine whether certain substances ( including all pesticide active and other ingredients) " may have an effect in humans that is similar to an effect produced by a naturally occurring estrogen, or other endocrine effects as the Administrator may designate." Following recommendations of its Endocrine Disruptor Screening and Testing Advisory Committee ( EDSTAC), EPA determined that there was a scientific basis for including, as part of the program, the androgen and thyroid hormone systems, in addition to the estrogen hormone system. EPA also adopted EDSTAC's recommendation that EPA include evaluations of potential effects in wildlife. For pesticides, EPA will use FIFRA and, to the extent that effects in wildlife may help determine whether a substance may have an effect in humans, FFDCA authority to require the wildlife evaluations. As the science develops and resources allow, screening of additional hormone systems may be added to the Endocrine Disruptor Screening Program ( EDSP).

In the chronic rat toxicity/ carcinogenicity study, TCMTB was associated with thyroid Ccell adenomas. Although these results were not seen as statistically significant, they may indicate an association with endocrine disruption. When the appropriate screening and/ or testing protocols being considered under the EDSP have been developed, TCMTB may be subject to additional screening and/ or testing to better characterize effects related to endocrine disruption.

e. Cumulative Risks Risks summarized in this document are those that result only from the use of TCMTB. The Food Quality Protection Act ( FQPA) requires that the Agency consider " available information" concerning the cumulative effects of a particular pesticide's residues and " other substances that have a common mechanism of toxicity." The reason for consideration of other substances is due to the possibility that low level exposures to multiple chemical substances that cause a common toxic effect by a common toxic mechanism could lead to the same adverse health effect as would a higher level of exposure to any of the substances individually. Unlike 52 other pesticides for which EPA has followed a cumulative risk approach based on a common mechanism of toxicity, EPA has not made a common mechanism of toxicity finding for TCMTB. For information regarding EPA's efforts to determine which chemicals have a common mechanism of toxicity and to evaluate the cumulative effects of such chemicals, see the policy statements released by EPA's Office of Pesticide Programs concerning common mechanism determinations and procedures for cumulating effects from substances found to have a common mechanism on EPA's website at http:// www. epa. gov/ pesticides/ cumulative/.

2. Tolerance Summary Tolerances for residues in/ on plant livestock commodities have been established under 40 CFR § 180.288. The permanent tolerances for residues in/ on plant commodities are established at the limit of quantitation ( LOQ) of 0.1 ppm ( N) and are expressed in term of residues of TCMTB per se [( 2 benzothiazolylthio) methyl thiocyanate].

Confirmatory metabolism data conducted with wheat, cotton, and sugar beet are necessary to determine the nature of residues in plants. Depending on the results from the confirmatory metabolism studies, additional guideline requirements may be requested for: livestock metabolism; storage stability; and magnitude of the residue studies on livestock, processed crop commodities, and magnitude of residue studies for rotational crops. A summary of the TCMTB tolerance reassessment is presented below in Table 26.

a. Currently Established Tolerances Under 40 CFR 180.288 & Tolerance Reassessment of TCMTB Tolerances for barley hay and cotton gin byproducts must be proposed. The " N" designation, denoting " negligible" residues, must be deleted from 40 CFR § 180.288. Use of TCMTB on sorghum and corn are no longer supported and, therefore, must be revoked under 40 CFR § 180.288. 53 Table 26. Established Tolerances and Tolerance Reassessment Summary Table for TCMTB Commodity Current Tolerance Tolerance Reassessment Comment/[ Correct Commodity Definition] Tolerances Established Under 40 CFR § 180.288: Barley, grain 0.1 ( N1) TBD2 Barley, straw 0.1 ( N) TBD Beet, sugar, roots 0.1 ( N) TBD Beet, sugar, tops 0.1 ( N) TBD Corn, grain 0.1 ( N) Revoke The registrants do not intend to support use of TCMTB on corn.

Corn, forage 0.1 ( N) Revoke The registrants do not intend to support use of TCMTB on corn.

Corn, stover 0.1 ( N) Revoke The registrants do not intend to support use of TCMTB on corn.

Cotton, forage 0.1 ( N) Revoke No longer considered a significant livestock feed item. Cotton, undelinted seed 0.1 ( N) TBD Oat, forage 0.1 ( N) TBD Oat, grain 0.1 ( N) TBD Oat, hay 0.1 ( N) TBD Oat, straw 0.1 ( N) TBD Rice, grain 0.1 ( N) TBD Rice, straw 0.1( N) TBD Safflower, seed 0.1 ( N) TBD Sorghum, grain, forage 0.1 ( N) Revoke The registrants do not intend to support use of TCMTB on sorghum.

Sorghum, grain, grain 0.1 ( N) Revoke The registrants do not intend to support use of TCMTB on sorghum.

Sorghum, grain, stover 0.1 ( N) Revoke The registrants do not intend to support use of TCMTB on sorghum. Wheat, forage 0.1 ( N) TBD Wheat, grain 0.1 ( N) TBD Wheat, hay 0.1 ( N) TBD Wheat, straw 0.1 ( N) TBD Tolerances To Be Proposed Under 40 CFR § 180.288: Barley, hay None established TBD Cotton, gin byproducts None established TBD 1. N = Negligible. The " N" designation must be removed from all tolerances. 2. TBD = To be determined. Tolerances cannot be determined at this time because additional data are required.

b. Codex of Harmonization There are no codex maximum residue limits ( MRLs) for TCMTB; therefore, no questions of compatibility with U. S. tolerances exist.

D. Regulatory Rationale The Agency has determined that TCMTB is eligible for reregistration provided that additional required data confirm this decision, the risk mitigation measures outlined in this document are adopted, and label amendments are made to reflect these measures. 54 The following is a summary of the rationale for managing risks associated with the uses of TCMTB. Where labeling revisions are warranted, specific language is set forth in the summary tables of Section V of this document.

1. Human Health Risk Management a. Dietary ( Food) Risk Mitigation The acute and chronic dietary risks from TCMTB residues on food, estimated using conservative measures are below the Agency's level of concern for the seed treatment and antimicrobial uses. Therefore, no mitigation measures are necessary at this time. Additional confirmatory metabolism data are required to verify that 2 MBT and other TCMTB metabolites are not residues of concern in plant commodities.

b. Drinking Water Risk Mitigation The Agency estimated drinking water exposure for the seed treatment use of TCMTB only, as no antimicrobial uses are expected to impact surface or groundwater resources. The drinking water concentrations did not result in risk of concern. Therefore, no mitigation measures are necessary at this time.

c. Residential Risk Mitigation i. Handler Risk Mitigation Residential handler risks were assessed for the application of TCMTB preserved paint via airless sprayer and paint brush/ roller ( antimicrobial uses) to determine dermal and inhalation exposure. Short term dermal risks of concern were identified for paint applicators using both airless sprayer and paint brush/ roller scenarios ( ST Dermal MOE of 10 for airless sprayer applications and ST Dermal MOE of 25 for paintbrush applications). The inhalation MOEs were above the target MOE of 300; however, the total dermal and inhalation MOEs for both application scenarios were under the target MOE of 100 and, thus, are risks of concern.

Because of remaining residential exposure concerns, the registrants for TCMTB have agreed to conduct a dermal exposure study for paint applicators that would allow the Agency to assess the risks associated with these uses. However, this study will not be completed in time for inclusion in this RED. Until acceptable exposure data are submitted, the Agency has determined that the residential use of TCMTB as a materials preservative in paints is ineligible for reregistration and this use must be deleted. The registrant has agreed that once the data has been determined to be acceptable, and if it is established that the risks are not of concern, the registrants can request that this use be reinstated.

ii. Post Application Risk Mitigation For the residential post application assessment, high end residential exposures were assessed for treated carpets ( dermal and incidental oral exposure to children) and treated 55 clothing/ leather products ( dermal exposure to adults/ children and incidental oral exposure to children). The short and intermediate term MOEs for dermal contact with treated clothing/ leather products were of concern for both young children and adults ( MOEs < 1 assuming 100% transfer factor; MOEs < 10 assuming 5% transfer factor). In addition, the shortterm MOEs for dermal and incidental oral contact with treated carpet were less then the target of 100 for children ( ST dermal MOE of 2, ST oral MOE of 4).

To address these risks all TCMTB textile preservative uses, with the exception of the leather preservative use, must be deleted. In addition, the registrant has agreed to conduct a study on TCMTB treated leather products to determine how much TCMTB would transfer onto skin through normal wear. This study, which is confirmatory data, is expected to further refine the risk assessment for the leather preservative use.

As a result of the cancellation of the textile use, the Agency has determined that all dermal and oral risks of concern pertaining to children will be eliminated. The rationale for this decision is that children are not likely to come into oral contact through mouthing of treated leather products. In addition, children are not likely to wear TCMTB treated leather products. Therefore, there are no remaining risks of concern for residential exposure of TCMTB treated leather products to children.

Preliminary data was submitted by the technical registrant, Buckman Laboratories, to the Agency regarding leaching of TCMTB from treated leather. This data estimated the amount of TCMTB that would transfer to the skin during normal wear of leather products. A preliminary review of this data was used to characterize risks associated with wearing treated leather and suggests that dermal risks from wearing these products well exceeds the target MOE of 100 for adults and, thus, is not of concern. Confirmatory leather leaching data is required to support these findings.

d. Occupational Risk Mitigation i. Handler Risk Mitigation Seed Treatment Use For commercial seed treatment, all dermal and inhalation MOEs met or exceeded the required uncertainty factor of 100 with baseline levels of PPE. Therefore, no mitigation is required.

Antimicrobial Use Dermal risks of concern were identified for six individual use scenarios ( paint preservation liquid pour, paint preservation liquid pump, textile preservation liquid pour, textile preservation liquid pump, cutting fluid preservation liquid pour, pulp and paper liquid pump) at the baseline level of evaluation ( no PPE gloves). To mitigate the risks for occupational handlers of material preservation for adhesives, pulp and paper and metalworking, these workers must wear chemical resistant gloves while handling TCMTB products. The use of chemical resistant 56 gloves eliminates the dermal risks of concern ( MOEs are well above 100 with the addition of gloves). Paint and textile uses, with the exception of leather, must be deleted based on residential risk concerns.

Short term and intermediate term dermal risks of concern were identified for occupational paint applicators with the use of an airless sprayer and paintbrush/ roller. These risks remained a concern, even with addition of PPE ( gloves). Because of remaining risk concerns associated with this use, the technical registrant for TCMTB has agreed to conduct a study that would allow the Agency to assess the risks associated with these uses. However, this study will not be completed in time for inclusion in this RED. Until acceptable exposure data are submitted, the Agency has determined that the occupational use of TCMTB in commercial and institutional premises for paint application is ineligible for reregistration and paint uses must be deleted. Once the data has been determined to be acceptable, and if it is established that the risks are not of concern, the registrants can request that this use be reinstated.

Dermal risks of concern were identified for occupational handlers of textiles and carpets being treated with TCMTB. To mitigate these risks all textile uses of TCMTB must be deleted, with the exception of leather. To mitigate the dermal risks for handlers during the manufacturing of leather products, pulp and paper products, and handling of metal cutting fluid, workers must wear gloves. The estimates for these risks are well over the target of 100 and are not of concern with the use of gloves.

The short, intermediate and long term risks for occupational handlers who apply TCMTB to wood for non pressure treatment were assessed. All of these risks were above the target MOEs of 100 ( short and intermediate term) and 300 ( long term), and are not of concern.

ii. Post Application Risk Mitigation For the occupational post application risk assessment of the seed treatment and antimicrobial uses of TCMTB, there are no risks of concern. Therefore, mitigation measures are not necessary at this time.

2. Environmental Risk Management Seed Treatment Use The Agency considers the seed treatment use of TCMTB assessed in this RED to be unlikely to result in any appreciable exposure to terrestrial or aquatic organisms. Therefore no environmental risk mitigation is required for the agricultural use of TCMTB at this time.

Antimicrobial Use For the antisapstain use of TCMTB, the Agency used a Tier I screening model to estimate exposures that could result from this use. The worst case ecological concern for the TCMTB antisapstain use is for chronic risk to fish with RQs ranging from 25   39. The estimated environmental concentrations ( EECs) exceed chronic levels of concern ( LOCs). It should be noted that this model has inherent assumptions and uncertainties that may result in over or under estimation of exposure levels. Additional information, including, specific leaching 57 data from TCMTB used as an antisapstain wood preservative would result in more accurate risk estimations. Therefore, the Agency is requesting an aerobic soil metabolism, anaerobic soil metabolism, and aerobic aquatic metabolism studies. Such data may remove uncertainties and may result in more accurate exposure estimations In addition, the following language must be placed on all antisapstain products to decrease leaching risks:

" Treated lumber must be stored under cover, indoors, or at least 100 feet from any pond, lake, stream, wetland, or river to prevent possible runoff of the product into the waterway. Treated lumber stored within 100 feet of a pond, lake, steam, or river must be either covered with plastic or surrounded by a berm to prevent surface water runoff into the nearby waterway. If a berm or curb is used around the site, it should consist of impermeable material ( clay, asphalt, concrete) and be of sufficient height to prevent runoff during heavy rainfall events."

Registrants are responsible for amending all TCMTB wood preservative product labels to incorporate the required label language, which will help mitigate ecological risks of concern.

To address exposure to non target insects, a special honeybee study is required for all wood preservative uses unless a statement prohibiting the use of treated wood in hive construction is added to the label such as, " Wood treated with TCMTB shall not be used in the construction of beehives." This study is a combination of Guidelines 171 4 and 850.3030 ( see information regarding residue data requirements for uses in beehives in the residue chemistry section of 40 CFR part 158). Numbers of bees used in this study and methods for collection/ introduction of bees into hives, feeding, and observations for toxicity and mortality should be consistent with those described in OPPTS Guideline 850.3030, " Honey Bee Toxicity of Residues on Foliage." The toxicity portion of this study is in lieu of the honeybee contact LD50 test.

3. Other Labeling Requirements In order to be eligible for reregistration, various use and safety information will be included in the labeling of all end use products containing TCMTB. For the specific labeling statements and a list of outstanding data, refer to Section V of this RED document.

4. Listed Species Considerations a. The Endangered Species Act Section 7 of the Endangered Species Act, 16 U. S. C. Section 1536( a)( 2), requires all federal agencies to consult with the National Marine Fisheries Service ( NMFS) for marine and anadromous listed species, or the United States Fish and Wildlife Services ( FWS) for listed wildlife and freshwater organisms, if they are proposing an " action" that may affect listed species or their designated habitat. Each federal agency is required under the Act to insure that any 58 action they authorize, fund, or carry out is not likely to jeopardize the continued existence of a listed species or result in the destruction or adverse modification of designated critical habitat. To jeopardize the continued existence of a listed species means " to engage in an action that reasonably would be expected, directly or indirectly, to reduce appreciably the likelihood of both the survival and recovery of a listed species in the wild by reducing the reproduction, numbers, or distribution of the species." 50 C. F. R. § 402.02.

To facilitate compliance with the requirements of the Endangered Species Act subsection ( a)( 2) the Environmental Protection Agency, Office of Pesticide Programs has established procedures to evaluate whether a proposed registration action may directly or indirectly reduce appreciably the likelihood of both the survival and recovery of a listed species in the wild by reducing the reproduction, numbers, or distribution of any listed species ( U. S. EPA 2004). After the Agency's screening level risk assessment is performed, if any of the Agency's Listed Species LOC Criteria are exceeded for either direct or indirect effects, a determination is made to identify if any listed or candidate species may co occur in the area of the proposed pesticide use. If determined that listed or candidate species may be present in the proposed use areas, further biological assessment is undertaken. The extent to which listed species may be at risk then determines the need for the development of a more comprehensive consultation package as required by the Endangered Species Act.

For certain use categories, the Agency assumes there will be minimal environmental exposure, and only a minimal toxicity data set is required ( Overview of the Ecological Risk Assessment Process in the Office of Pesticide Programs U. S. Environmental Protection Agency  Endangered and Threatened Species Effects Determinations, 1/ 23/ 04, Appendix A, Section IIB, pg. 81). Chemicals in these categories therefore do not undergo a full screening level risk assessment, and are considered to fall under a no effect determination. The active ingredient uses of TCMTB, with the exception of the seed treatment and antisapstain wood preservation uses, fall into this category. Using Tier I screening modeling to assess potential exposure from seed treatment risks to Listed Species were not identified. Using Tier I screening modeling to assess potential exposure from antisapstain wood preservation uses of TCMTB, risks to Listed Species are indicated. Since the model is only intended as a screening level model, and, as such, has inherent uncertainties and limitations which may result in inaccurate exposure estimations, further refinement of the model is recommended before any regulatory action is taken regarding the antisapstain uses of TCMTB. Additionally, impacts from the antisapstain use could potentially be mitigated with precautions to prevent leaching and runoff when wood is stored outdoors ( see General Risk Mitigation, below). Due to these circumstances, the Agency defers making a determination for the antisapstain uses of TCMTB until additional data and modeling refinements are available. At that time, the environmental exposure assessment of the antisapstain use of TCMTB will be revised, and the risks to Listed Species will be reconsidered.

b. General Risk Mitigation TCMTB end use products ( EPs) may also contain other registered pesticides. Although the Agency is not proposing any mitigation measures for products containing TCMTB specific to federally listed species, the Agency needs to address potential risks from other end use products. Therefore, the Agency requires that users adopt all listed species risk mitigation measures for all active ingredients in the product. If a product contains multiple active ingredients with 59 conflicting listed species risk mitigation measures, the more stringent measure( s) should be adopted. 60 V. What Registrants Need to Do The Agency has determined that TCMTB is eligible for reregistration provided that: ( i) additional data that the Agency intends to require confirm this decision; ( ii) the risk mitigation measure outlined in this document is adopted; and ( iii) label amendments are made to reflect this measure. To implement the risk mitigation measure, the registrants must amend their product labeling to incorporate the label statement set forth in the Label Changes Summary Table in Section B below ( Table 24). The additional data requirements that the Agency intends to obtain will include, among other things, submission of the following:

For TCMTB technical grade active ingredient products, the registrant needs to submit the following items:

Within 90 days from receipt of the generic data call in ( DCI):

1. Completed response forms to the generic DCI ( i. e., DCI response form and requirements status and registrant's response form); and 2. Submit any time extension and/ or waiver requests with a full written justification.

Within the time limit specified in the generic DCI:

1. Cite any existing generic data which address data requirements or submit new generic data responding to the DCI.

Please contact K. Avivah Jakob at ( 703) 305 1328 with questions regarding generic reregistration.

By US mail: By express or courier service:

Document Processing Desk Document Processing Desk K. Avivah Jakob K. Avivah Jakob Office of Pesticide Programs Office of Pesticide Programs ( 7510P) ( 7510P) U. S. Environmental Protection Agency U. S. Environmental Protection Agency 1200 Pennsylvania Ave., NW One Potomac Yard, Room S 4900 Washington, DC 20460 0001 2777 South Crystal Drive Arlington, VA 22202 61 For end use products containing the active ingredient TCMTB, the registrant needs to submit the following items for each product.

Within 90 days from the receipt of the product specific data call in ( PDCI):

1. Completed response forms to the PDCI ( i. e., PDCI response form and requirements status and registrant's response form); and 2. Submit any time extension or waiver requests with a full written justification.

Within eight months from the receipt of the PDCI:

1. Two copies of the confidential statement of formula ( EPA Form 8570 4);

2. A completed original application for reregistration ( EPA Form 8570 1). Indicate on the form that it is an " application for reregistration";

3. Five copies of the draft label incorporating all label amendments outlined in Table 23 of this document;

4. A completed form certifying compliance with data compensation requirements ( EPA Form 8570 34);

5. If applicable, a completed form certifying compliance with cost share offer requirements ( EPA Form 8570 32); and 6. The product specific data responding to the PDCI.

Please contact Marshall Swindell at ( 703) 308 6341 with questions regarding product reregistration and/ or the PDCI. All materials submitted in response to the PDCI should be addressed as follows:

By US mail: By express or courier service:

Document Processing Desk Document Processing Desk Marshal Swindell Marshal Swindell Office of Pesticide Programs ( 7510P) Office of Pesticide Programs ( 7510P) U. S. Environmental Protection Agency U. S. Environmental Protection Agency 1200 Pennsylvania Ave., NW Room S 4900, One Potomac Yard Washington, DC 20460 0001 2777 South Crystal Drive Arlington, VA 22202 62 A. Manufacturing Use Products 1. Additional Generic Data Requirements The generic database supporting the reregistration of TCMTB has been reviewed and determined to be substantially complete. However, the following additional data requirements have been identified by the Agency as confirmatory data requirements and are included in the generic data call in ( DCI) for this RED.

Data must be submitted indicating whether the use of TCMTB, as an antimicrobial materials preservative, in pulp and papermaking will result in residues of 2 MBT in paper. The registrant must also provide information regarding the level of 2 MBT that will occur in paper. Application rates ( ranges) on all TCMTB paper coating use labels must be identified/ clarified.

The risk assessment noted deficiencies in the surrogate inhalation exposure data available from the Chemical Manufacturers Association ( CMA) data base. Therefore, the Agency is requiring confirmatory data to support the uses assessed with the CMA exposure data within this risk assessment. The risk assessment also noted that many of the use parameters ( e. g., amount handled and duration of use) were base on professional judgments. Therefore, descriptions of human activities associated with the uses assessed are required as confirmatory.

The requested environmental fate and ecological studies outline in Table 24 are data gaps for the seed treatment and/ or wood preservative uses of TCMTB.

Table 24. Data Requirements for TCMTB Guideline Study Name New OPPTS Guideline Number Old Guideline Number Anaerobic soil metabolism 835.4200 162 2 Terrestrial field dissipation 835.6100 164 1 Aquatic Field Study 835.6200 164 2 Aquatic Invertebrate Life Cycle Study 850.1400 72 4b Life Cycle Fish Study 850.1500 72 5 Terrestrial Plant Toxicity, Tier I ( seedling emergence) 850.4100 122 1a Seedling emergence, Tier II 850.4225 123 1 Vegetative vigor with Rice, Tier II 850.4250 123 1 Aquatic Plant Growth, Tier II 850.5400 123 2 Plant Metabolism 860.1300 171 4a Residue Analytical Methods Plant Commodities 860.1340 171 4c Storage Stability Data Plant Commodities 860.1380 171 4e Processed Food/ Feed Barley 860.1520 171 4l Processed Food/ Feed Beet, Sugar 860.1520 171 4l Processed Food/ Feed Cotton 860.1520 171 4l Processed Food/ Feed Oat 860.1520 171 4l 63 Processed Food/ Feed Rice 860.1520 171 4l Processed Food/ Feed Safflower 860.1520 171 4l Processed Food/ Feed Wheat 860.1520 171 4l Proposed Tolerances 860.1550 171 6 Submittal of Analytical Reference Standards 860.1650 171 13 Dermal Indoor Exposure 875.1200 233 Inhalation Indoor Exposure 875.1400 234 Description of Human Activity 875.2800 133 1 Leather Leaching Data Special Study Special Study Residues in honey/ beeswax and toxicity of treated wood residues to bees No Guideline No Guideline Reserved Confirmatory Data Requirements for Reregistration Terrestrial Plant Toxicity, Tier II ( seedling emergence) 850.4225 123 1 Livestock Metabolism 860.1300 171 4b Residue Analytical Methods Livestock Commodities 860.1340 171 4d Multi residue Methods 860.1360 171 4m Storage Stability Data Processed Commodities 860.1380 171 4e Storage Stability Data Livestock Commodities 860.1380 171 4e Meat, Milk, Poultry, and Eggs 860.1480 171 4i Crop Field Trials Beat, Sugar, Tops ( Root and Tuber Vegetables Group) 860.1500 171 4k Crop Field Trials Beet, Sugar, Tops ( Leaves of Root and Tuber Vegetables Group) 860.1500 171 4k Crop Field Trials Barley, Grain ( Cereal Grains Group) 860.1500 171 4k Crop Field Trials Oat, Grain ( Cereal Grains Group) 860.1500 171 4k Crop Field Trials Rice, Grain ( Cereal Grains Group) 860.1500 171 4k Crop Field Trials Wheat, Grain and Aspirated Grain Fractions ( Cereal Grains Group) 860.1500 171 4k Crop Field Trials Barley, Hay and Straw ( Fodder, Forage, Hay and Straw of Cereal Grains Group) 860.1500 171 4k Crop Field Trials Oat, Forage, Hay and Straw ( Fodder, Forage, Hay and Straw of Cereal Grains Group) 860.1500 171 4k Crop Field Trials Rice, Straw ( Fodder, Forage, Hay and Straw of Cereal Grains Group) 860.1500 171 4k 64 Crop Field Trials Wheat, Forage, Hay, and Straw ( Fodder, Forage, Hay and Straw of Cereal Grains Group) 860.1500 171 4k Crop Field Trials Cotton, Undelinted Seed and Gin Byproducts ( Miscellaneous Commodities) 860.1500 171 4k Confined Rotational Crops 860.1850 165 1 Field Rotational Crops 860.1900 165 2 2. Labeling for Technical and Manufacturing Use Products To ensure compliance with FIFRA, technical and manufacturing use product ( MP) labeling should be revised to comply with all current EPA regulations, PR Notices and applicable policies. The Technical and MP labeling should bear the labeling contained in Table 25, Label Changes Summary Table.

B. End Use Products 1. Additional Product Specific Data Requirements Section 4( g)( 2)( B) of FIFRA calls for the Agency to obtain any needed product specific data regarding the pesticide after a determination of eligibility has been made. The Registrant must review previous data submissions to ensure that they meet current EPA acceptance criteria and if not, commit to conduct new studies. If a registrant believes that previously submitted data meet current testing standards, then the study MRID numbers should be cited according to the instructions in the Requirement Status and Registrants Response Form provided for each product. A product specific data call in will be issued at a later date.

2. Labeling for End Use Products Labeling changes are necessary to implement measures outlined in Section IV above. Specific language to incorporate these changes is specified in Table 25, Label Changes Summary Table.

Registrants may generally distribute and sell products bearing old labels/ labeling for 26 months from the date of the issuance of this Reregistration Eligibility Decision document. Persons other than the registrant may generally distribute or sell such products for 52 months from the approval of labels reflecting the mitigation described in this RED. However, existing stocks time frames will be established case by case, depending on the number of products involved, the number of label changes, and other factors. Refer to " Existing Stocks of Pesticide Products; Statement of Policy," Federal Register, Volume 56, No. 123, June 26, 1991.

a. Label Changes Summary Table In order to be eligible for reregistration, all product labels must be amended to incorporate the risk mitigation measure outlined in Section IV of the TCMTB RED. The following table describes how language on the labels should be amended. 65 Table 25. Labeling Changes Summary Table Description Amended Labeling Language Placement on Label Environmental Hazards Statements Required by the RED and Agency Label Policies " This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." Precautionary Statements End Use Products Intended for Occupational Use PPE Requirements " Wear chemical resistant gloves while handling concentrate." Immediately following/ below Precautionary Statements: Hazards to Humans and Domestic Animals For all antisapstain end use products " Treated lumber must be stored under cover, indoors, or at least 100 feet from any pond, lake,

stream, wetland, or river to prevent possible runoff of the product into the waterway. Treated lumber stored within 100 feet of a pond, lake, steam, or river must be either covered with plastic or surrounded by a berm to prevent surface water runoff into the nearby waterway. If a berm or curb is used around the site, it should consist of impermeable material ( clay, asphalt,

concrete) and be of sufficient height to prevent runoff during heavy rainfall events." This language is to be included in the Environmental Hazards section of the label.

Directions For Use Use Cancellation All TCMTB textile materials preservative/ additive incorporation uses are cancelled and must be deleted from current product labels, with the exception use on leather. Examples of cancelled textiles are carpets, fibers and cordage.

Use Cancellation All TCMTB paint preservation/ application uses are cancelled and must be deleted from all product labels. 66 VI. APPENDICES 67 Appendix A. Table of Use Patterns for TCMTB Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Materials preservatives Leather Soluble Concentrate 1448 55 1448 81 1448 377 1448 412 Add to pickling liquor or tanning liquor at the start of the tanning process or to the rinse water in a post tanning refloat The dosage level used will depend on storage conditions and the length of protection required.

A dosage rate of 0.025 0.3%

( 250 2,000 ppm) can be used.

A satisfactory dilution of 1 part solution to 5 parts water can be prepared. Per TCMTB RED mitigation, occupational handlers of antimicrobial materials preservative products must wear PPE chemical resistant gloves while handling concentrate.

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 68 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Leather 1448 386 1448 102 1448 100 1448 376 1448 408 1.5 to 12.0 lbs per 1,000 lbs of white weight stock. Per TCMTB RED mitigation, occupational handlers of antimicrobial materials preservative products must wear PPE chemical resistant gloves while handling concentrate.

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 69 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Soluble concentrate 1448 55 1448 81 1448 99 1448 100 1448 377 0.1 to 3% based on the dry weight of the wood. Per TCMTB RED mitigation, occupational handlers of antimicrobial materials preservative products must wear PPE chemical resistant gloves while handling concentrate.

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA."

Particle Board 1448 386 Mix with resin or binding agent 0.6 to 6.0% based on the dry weight of the wood. Per TCMTB RED mitigation, occupational handlers of antimicrobial materials preservative products must wear PPE chemical resistant gloves while handling concentrate.

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 70 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Coatings,

caulkingsealants & wall cover adhesives,

pigment slurries,

non food adhesives Soluble concentrate 1448 45 1448 55 1448 81 1448 99 1448 100 1448 102 1448 376 1448 377 44392 11 Incorporation ( mixing) 0.5 to 36% based on the total formulation weight.

For solvent based formulations use combinations of aromatic and aliphatic solvents. Per TCMTB RED mitigation, occupational handlers of TCMTB antimicrobial materials preservative products must wear PPE chemical resistant gloves while handling concentrate.

Per TCMTB RED mitigation, all TCMTB paint preservation/ application uses are cancelled and must be deleted from all product labels.

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA."

Textiles Soluble concentrate 1448 55 Impregnate Apply solution to an emulsion of convenient concentration of 1 5% impregnate into the fabric using conventional padding or sizing equipment Per TCMTB RED mitigation, all TCMTB textile materials preservative/ additive incorporation uses are cancelled and must be deleted from current product labels, with the exception of use on leather. Examples of cancelled textiles are carpets, fibers and cordage. 71 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Crude and refined oils Soluble concentrate 1448 81 1448 99 1448 100 1448 102 1448 147 1448 148 1448 171 1448 172 1448 376 1448 386 1448 377 44392 11 Incorporation Chemical should be added to the oil as it is being transferred from the shipping container to the storage tank at a rate of 0.6 to 32 fl oz per 1,000 gal of oil. Per TCMTB RED mitigation, occupational handlers of antimicrobial materials preservative products must wear PPE chemical resistant gloves while handling concentrate.

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA."

Hides and skins Soluble concentrate 1448 55 1448 81 1448 99 1448 102 1448 376 1448 377 1448 408 1448 412 None stated The solution should be used at a level of 0.003% to 0.02%

( 30 to 200ppm) based on the weight of the green fleshed hides or skins and saturated brine solution. Per TCMTB RED mitigation, occupational handlers of antimicrobial materials preservative products must wear PPE chemical resistant gloves while handling concentrate.

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 72 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Fuels Soluble concentrate 1448 102 1448 148 1448 147 1448 171 1448 172 44392 11 Incorporation 125 to 25 fl oz per 100 gallons of fuel.

 or

3.0 to 6.0 fl oz per 1,000 gal of fuel. Per TCMTB RED mitigation, occupational handlers of antimicrobial materials preservative products must wear PPE chemical resistant gloves while handling concentrate.

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 73 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Bacteriostatic paper Soluble concentrate 1448 81 1448 377 None stated Dosage: 0. 5% to 9.0%

weight/ weight of product and added at the size press or similar application. The bacteriostatic paper and paperboard applications are not to be used in the manufacture of food contact paper,

paper coatings or paperboard.

Per TCMTB RED mitigation, occupational handlers of antimicrobial materials preservative products must wear PPE chemical resistant gloves while handling concentrate.

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 74 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Industrial processes and water systems Pulp mills Soluble concentrate 1448 45 1448 55 1448 81 1448 99 1448 100 1448 102 1448 376 1448 383 1448 377 1448 386 Spray Applicator rolls 0.5 to 12.0 lb per ton of oven dry wood ( 50 to 400 ppm).

It can be applied through a water shower located in the pneumatic conveyor carrying chips from the chipper to the storage pile.

To control bacteria and fungal growth on paper and paper board machines add to the white water or stock 0.1 to 12.0 lb/ ton of dry paper.

To make mold resistant paper or paperboard use at 0.05 to 0.6lb/ 1000 sq ft.

For coated paper or board, the solution is incorporated in the coating mix prior to application.

For uncoated paper or board,

the solution is dispersed in water, surface sizing solution,

or other solvent and applied to the surface to be protected by means of applicator roller.

For mulch paper 1.5 to 5lb/ ton air dry paper. Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 75 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Soluble concentrate 1448 55 1448 81 1448 147 1448 148 1448 149 1448 150 1448 377 Initial dose:

0.6 to 3.7 fl oz per 1,000 gallons of water in the system.

Subsequent dose:

0.2 to 1.2 fl oz per 1,000 gallons should be made every 1 to 5 days. Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA."

Cooling Water 1448 100 1448 152 1448 153 1448 386 1448 408 Fill, Flush Fill, Flush 3.6 to 22.2 fl oz. per 1,000 gallons of water. Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 76 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Cooling Water 1448 99 1448 102 1448 151 1448 171 1448 172 1448 244 1448 376 1448 383 44392 11 1.3 to 14.8 fl oz per 1,000 gallons of water. Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA."

Drilling Fluids Soluble concentrate 1448 55 1448 81 1448 99 1448 100 1448 102 1448 147 1448 148 1448 149 1448 150 1448 151 1448 152 1448 153 1448 171 1448 172 1448 376 1448 383 1448 386 1448 377 1448 408 44392 11 Incorporation in the drilling fluid. 0.05% to 1.5 % based on the total wet weight of the fluid. Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 77 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Petroleum Secondary Recovery Soluble concentrate 1448 55 1448 81 1448 99 1448 100 1448 102 1448 147 1448 148 1448 149 1448 150 1448 151 1448 152 1448 153 1448 171 1448 172 1448 376 1448 383 1448 386 1448 377 1448 244 44392 11 Continuous feed method Intermittent feed Slug feed 0.2 to 6.3 fl oz per 100 gallons of Water.

0.65 to 10 fl oz per 1,000 gallons of water 4 to 8 hrs per day.

1.3 to 13.0 fl oz per 1,000 gallons of water every 1 to 7 days,

15.6 to 52.0 fl oz per 1000 gallons of water every 1 to 7 days. 78 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Cutting fluids Soluble concentrate 1448 55 1448 99 1448 100 1448 149 1448 150 1448 151 1448 152 1448 153 1448 386 1448 265 1448 244 Incorporation Solution should be added to diluted cutting fluid at a rate that will provide 150 to 1,500 ppm.

To prevent fungal growth,

concentrations of 1,000 to 7,500ppm are necessary. Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA."

Waste water treatment systems Soluble concentrate 1448 55 None stated The quantity of solution required varies with the degree of fouling.

It should be added at a rate that will provide 10 to 30 ppm of the waste water. Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 79 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Wood Preservatives Sapstain Control 1448 55 1448 81 Dipping/ Pressure Impregnation 0.5 to 8 gal of product ( 10%

TCMB) per 100 gal of water. Treatment should be made within 24 hrs of cutting or sawing.

Per RED mitigation, the following language must appear on all products with an antisapstain use:

" Treated lumber must be stored under cover, indoors, or at least 100 feet from any pond, lake, stream, wetland, or river to prevent possible runoff of the product into the waterway. Treated lumber stored within 100 feet of a pond, lake, steam, or river must be either covered with plastic or surrounded by a berm to prevent surface water runoff into the nearby waterway. If a berm or curb is used around the site, it should consist of impermeable material ( clay, asphalt, concrete) and be of sufficient height to prevent runoff during heavy rainfall events."

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 80 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Sapstain Control 1448 102 Dipping/ Pressure Impregnation 5.6 kg to 44.0 kg of product ( 5% TCMB) per 100 liters of water. Treatment should be made within 24 hrs of cutting or sawing.

Per RED mitigation, the following language must appear on all products with an antisapstain use:

" Treated lumber must be stored under cover, indoors, or at least 100 feet from any pond, lake, stream, wetland, or river to prevent possible runoff of the product into the waterway. Treated lumber stored within 100 feet of a pond, lake, steam, or river must be either covered with plastic or surrounded by a berm to prevent surface water runoff into the nearby waterway. If a berm or curb is used around the site, it should consist of impermeable material ( clay, asphalt, concrete) and be of sufficient height to prevent runoff during heavy rainfall events."

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 81 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Sapstain Control 1448 100 1448 99 Dipping/ Pressure Impregnation 1.5 to 48 gal of product ( 5 to 10% TCMB) per 100 gal of water. Treatment should be made within 24 hrs of cutting or sawing.

Per RED mitigation, the following language must appear on all products with an antisapstain use:

" Treated lumber must be stored under cover, indoors, or at least 100 feet from any pond, lake, stream, wetland, or river to prevent possible runoff of the product into the waterway. Treated lumber stored within 100 feet of a pond, lake, steam, or river must be either covered with plastic or surrounded by a berm to prevent surface water runoff into the nearby waterway. If a berm or curb is used around the site, it should consist of impermeable material ( clay, asphalt, concrete) and be of sufficient height to prevent runoff during heavy rainfall events."

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 82 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Vertical Wood Surfaces, roofs and sidewalls 56156 1 Brush or low pressure sprayer Sidewalls   first coat: 100 sq.

ft. per gallon, second coat 200 sq ft. per gallon Roofs   75 to 150 sq. ft. per gallon depending on porosity of surface.

VOC Content limit: less than 500 grams per liter or 4.6 lbs.

per gallon Do not apply this product in a way that will contact workers or other persons.

Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA."

Cooling Tower Wood 1448 55 1448 81 Brush or periodic shock dose Brush: 0.5 to 0.7% of product in water onto surface.

( provides 0.6 to 0.8 lbs per 1000 sq. ft. of wood surface)

Shock Dose: 1.25 lb of product per 1000 gallons of water. Bleedoff should be stopped for 4 to 6 hrs after treatment. Repeat shock treatment every four months. Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 83 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations 1448 302 Brush or periodic shock dose Brush: 2.0 to 2.8% of product in water onto surface.

( provides 2.4 to 3.2 lbs per 1000 sq. ft. of wood surface)

Shock Dose: 5.0 lb of product per 1000 gallons of water.

Bleedoff should be stopped for 4 to 6 hrs after treatment.

Repeat shock treatment every four months. Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA."

Cooling Tower Wood 1488 100 Brush or periodic shock dose Brush: 3.0 to 4.2% of product in water onto surface.

( provides 3.6 to 4.8 lbs per 1000 sq. ft. of wood surface)

Shock Dose: 7.5 lb of product per 1000 gallons of water.

Bleedoff should be stopped for 4 to 6 hrs after treatment.

Repeat shock treatment every four months. Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 84 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Seed Treatment Barley Seed, Oat Seed, Rice Seed,

Wheat Seed Liquid Concentrate 2935 389 Commercial treater Maximum application rate:

0.026 lbs ai/ 100 lbs of seed Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA."

Cotton Liquid Concentrate 264 965 264 983 2935 413 2935 389 Commercial treater On farm treater Maximum application rate ( commercial treater):

0.13 lbs ai/ 100 lbs of seed Maximum application rate ( on farm treater):

0.051 lbs ai/ 100 lbs of seed Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 85 Use Site Formulation/

EPA No. Method of Application Application Rate/ No.

of applications Use Limitations Safflower Seed,

Sugar beet Seed Liquid Concentrate 2935 389 Commercial treater Maximum application rate:

0.041 lbs ai/ 100 lbs of seed Per TCMTB RED mitigation, all TCMTB labels must state the following:

" This product is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System ( NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA." 86 Appendix B. Table of Generic Data Requirements and Studies Used to Make the Reregistration Decision Guide to Appendix B Appendix B contains listing of data requirements which support the reregistration for active ingredients within case # 2625( TCMTB) covered by this RED. It contains generic data requirements that apply to TCMTB in all products, including data requirements for which a " typical formulation" is the test substance.

The data table is organized in the following formats:

1. Data Requirement ( Column 1). The data requirements are listed in the order in which they appear in 40 CFR part 158.

The reference numbers accompanying each test refer to the test protocols set in the Pesticide Assessment Guidance, which are available from the National technical Information Service, 5285 Port Royal Road, Springfield, VA 22161 ( 703) 487 4650.

2. Use Pattern ( Column 4). This column indicates the use patterns for which the data requirements apply. The following letter designations are used for the given use patterns.

( 1) Agricultural premises and equipment ( 2) Food handling/ storage establishments' premises and equipment ( 3) Commercial, institutional and industrial premises and equipment ( 4) Residential and public access premises ( 5) Medical premises and equipment ( 6) Human water systems ( 7) Materials preservatives ( 8) Industrial processes and water systems ( 9) Antifouling coatings ( 10) Wood preservatives ( 11) Swimming pools ( 12) Aquatic areas 3. Bibliographic Citation ( Column 5). If the Agency has acceptable data in its files, this column list the identify number of each study. This normally is the Master Record Identification ( MRID) number, but may be a " GS" number if no MRID number has been assigned. Refer to the Bibliography appendix for a complete citation of the study. 87 DATA REQUIREMENT CITATION( S)

New Guideline Number Old Guideline Number Study Title Use Pattern MRID Number PRODUCT CHEMISTRY 830.1550 61 1 Product Identity and Composition 1,3, 4, 7,8,10 41612001 830.1600 830.1620 830.1650 61 2a Starting Materials and Manufacturing Process 1,3, 4, 7,8,10 41612001 830.1670 61 2b Formation of Impurities 1,3, 4, 7,8,10 41612001 830.1700 62 1 Preliminary Analysis 1,3, 4, 7,8,10 41612002 830.1750 62 2 Certification of Limits 1,3, 4, 7,8,10 41612002 830.1800 62 3 Analytical Method 1,3, 4, 7,8,10 41612002 830.6302 63 2 Color 1,3, 4, 7,8,10 41612003 830.6303 63 3 Physical State 1,3, 4, 7,8,10 41612003 830.6304 63 4 Odor 1,3, 4, 7,8,10 41612003 830.7220 63 6 Boiling Point 1,3, 4, 7,8,10 41612003, 42407401 830.7300 63 7 Density 1,3, 4, 7,8,10 41612003 830.7840 830.7860 63 8 Solubility 1,3, 4, 7,8,10 42059701, 41612003 830.7950 63 9 Vapor Pressure 1,3, 4, 7,8,10 41612003, 42059701 830.7550 830.7560 830.7570 63 11 Partition Coefficient ( Octanol/ Water) 1,3, 4, 7,8,10 4232450,4205970, 41612003 830.7000 63 12 pH 1,3, 4, 7,8,10 41612003 830.6313 63 13 Stability 1,3, 4, 7,8,10 41612003 830.6314 63 14 Oxidizing/ Reducing Action 1,3, 4, 7,8,10 41612003 830.6315 63 15 Flammability 1,3, 4, 7,8,10 41612003 88 DATA REQUIREMENT CITATION( S)

New Guideline Number Old Guideline Number Study Title Use Pattern MRID Number 830.6316 63 16 Explodability 1,3, 4, 7,8,10 41612003 830.6317 63 17 Storage Stability 1,3, 4, 7,8,10 41612003 830.7100 63 18 Viscosity 1,3, 4, 7,8,10 41612003 830.6319 63 19 Miscibility 1,3, 4, 7,8,10 41612003 830.6320 63 20 Corrosion Characteristics 1,3, 4, 7,8,10 41612003 830.6321 63 21 Dielectric breakdown voltage 1,3, 4, 7,8,10 41612003 ECOLOGICAL EFFECTS 850.2100 71 1a Avian Acute Oral Toxicity Test Quail/ Duck 1,3, 4, 7,8,10 41780901 850.2100 71 1b Avian Acute Oral Toxicity Test Quail/ Duck TEP 1,3, 4, 7,8,10 41780901 850.2200 71 2a Avian Acute Dietary Toxicity Quail 1,3, 4, 7,8,10 41595602, 42428501 850.2200 71 2b Avian Dietary Toxicity Duck 1,3, 4, 7,8,10 41595601 850.1075 72 1a Fish Acute Toxicity   Freshwater Bluegill 1,3, 4, 7,8,10 41804201 850.1075 72 1c Fish Toxicity Rainbow Trout 1,3, 4, 7,8,10 41818101 850.1010 72 2a Acute Aquatic Invertebrate Toxicity 1,3, 4, 7,8,10 41838201, 42226001 850.1075 72 3a Acute Estuarine/ Marine Toxicity  Fish 1,3, 4, 7,8,10 40363601 72 3b Acute Estuarine/ Marine Toxicity  Invertebrate ( Mollusk) 1,3, 4, 7,8,10 40363603 850.1025 72 3c Estuarine/ Marine Toxicity  Invertebrate ( Shrimp) 1,3, 4, 7,8,10 40363602 850.1300 72 4a Fish Early Life Stage Testing 1,3, 4, 7,8,10 425929 01 850.1400 72 4b Aquatic Invertebrate Life Cycle 1,3, 4, 7,8,10 Data Gap 850.1500 72 5 Life Cycle Fish 1,3, 4, 7,8,10 Data Gap 850.1710 72 6 Aquatic Org. Accumulation 1,3, 4, 7,8,10 42418501, 46705201, 42453201 89 DATA REQUIREMENT CITATION( S)

New Guideline Number Old Guideline Number Study Title Use Pattern MRID Number 850.4100 122 1a Terrestrial Plant Toxicity, Tier I ( seeding emergence) 1,3, 4, 7,8,10 Data Gap 850.4400 123 2 Aquatic Vascular Plant Toxicity, Tier II 1,3, 4, 7,8,10 442009 01 850.5400 123 2 Aquatic Plant Growth, Tier II 1,3, 4, 7,8,10 Data Gap 850.4225 123 1 Seedling Emergence Tier II 1,3, 4, 7,8,10 Data Gap 850.4250 123 1 Vegetative Vigor with Rice Tier II 1,3, 4, 7,8,10 Data Gap 875.2100 132 1a Foliar Residue Dissipation   not an eco requirement, check with fate/ residue chem 1,3, 4, 7,8,10 Waived None None Honey Bee Wood Preservative Residues Test 1,3, 4, 7,8,10 Data Gap ( Unless label statement prohibiting use for beehive construction is added)

TOXICOLOGY 870.1100 81 1 Acute Oral  Rat 1,3, 4, 7,8,10 41583801 870.1200 81 2 Acute Dermal  Rabbit 1,3, 4, 7,8,10 41515401 870.1300 81 3 Acute Inhalation  Rat 1,3, 4, 7,8,10 40419301, 41640601 870.2400 81 4 Primary Eye Irritation  Rabbit 1,3, 4, 7,8,10 Acc. No. 111991 870.2500 81 5 Primary Dermal Irritation  Rabbit 1,3, 4, 7,8,10 41583701 870.2600 81 6 Dermal Sensitization 1,3, 4, 7,8,10 42349201, Acc No. 259676 82 1a 90 Day Feeding Rodent 1,3, 4, 7,8,10 41342201 870.3100 82 1b 90 Day Feeding Non Rodent 1,3, 4, 7,8,10 41342201 870.3200 82 2 21/ 28 Day Dermal Toxicity   Rat/ Rabbit 1,3, 4, 7,8,10 41655801 870.3465 82 4 90 Day Inhalation Toxicity 1,3, 4, 7,8,10 Reserved 870.3700 83 3 Developmental Toxicity 1,3, 4, 7,8,10 00154295, Accession no. 260491,

40075102 90 DATA REQUIREMENT CITATION( S)

New Guideline Number Old Guideline Number Study Title Use Pattern MRID Number 870.3800 83 4 Reproduction and Fertility Effects  2 Generation Repro Rat 1,3, 4, 7,8,10 41471401 83 1a Chronic Feeding Toxicity  Rodent 1,3, 4, 7,8,10 41342201 870.4100 83 1b Chronic Feeding Toxicity  Non Rodent 1,3, 4, 7,8,10 41342201 83 2a Oncogenicity  Rat 1,3, 4, 7,8,10 42383001 870.4200 83 2b Oncogenicity  Mouse 1,3, 4, 7,8,10 42383001 870.3700a 83 3a Teratogenicity Rat 1,3, 4, 7,8,10 00154295, accession no. 260491 870.3700b 83 3b Teratogenicity Rabbit 1,3, 4, 7,8,10 40075102 870.4300 83 5 Combined Chronic Toxicity/ Carcinogenicity in Rats 1,3, 4, 7,8,10 42116301, 41529701, 41570301 870.5100 84 2 Mutagenicity study Gene mutation 1,3, 4, 7,8,10 41386101 870.5395 84 2 Mutagenicity C Mammalian erythrocyte micronucleus 1,3, 4, 7,8,10 00165520 870.5550 84 4 Rat Primary Hepatocyte Unscheduled DNA Synthesis Assay 1,3, 4, 7,8,10 00165518 870.7485 85 1 General Metabolism 1,3, 4, 7,8,10 40884801 ( upgradeable)

The study does not fulfill the complete requirements for a metabolism study, as incomplete identification of metabolites and the purity of TCMTB was not reported.

Only a single low does and a single high does were tested, a repeated does is required.

OCCUPATIONAL/ RESIDENTIAL EXPOSURE 875.2800 133 1 Description of Human Activity 1,3, 4, 7,8,10 Data Gap 875.2400 875.2900 133 3 Dermal Passive Dosimetry 1,3, 4, 7,8,10 Waived 875.1200 875.1600 233 Dermal Indoor Exposure 1,3, 4, 7,8,10 Data Gap 91 DATA REQUIREMENT CITATION( S)

New Guideline Number Old Guideline Number Study Title Use Pattern MRID Number 875.1400 875.1600 234 Inhalation Indoor Exposure 1,3, 4, 7,8,10 Data Gap ENVIRONMENTAL FATE 835.2120 161 1 Hydrolysis 1,3, 4, 7,8,10 Upgradeable 42386101, 43437601 835.2240 161 2 Photodegradation water 1,3, 4, 7,8,10 42630901 835.2410 161 3 Photodegradation soil 1,3, 4, 7,8,10 41515701 835.4100 162 1 Aerobic Soil Metabolism 1,3, 4, 7,8,10 Upgradeable 435322 01 835.4200 162 2 Anaerobic Soil Metabolism 1,3, 4, 7,8,10 Data Gap 835.4400 162 3 Anaerobic Aquatic Metabolism 1,3, 4, 7,8,10 428154 01 835.4300 162 4 Aerobic Aquatic Metabolism 1,3, 4, 7,8,10 Upgradeable 425086 01 835.1240 163 1 Leach/ Adsorption/ Desorption 1,3, 4, 7,8,10 426314 01 835.1240 163 1 Soil Column Leaching 1,3, 4, 7,8,10 Data Gap 835.6100 164 1 Terrestrial Field Dissipation 1,3, 4, 7,8,10 Data Gap 835.6200 164 2 Aquatic Field Study 1,3, 4, 7,8,10 Data Gap 850.1730 165 4 Accumulation Studies in Fish 1,3, 4, 7,8,10 424185 01, 424932 01, 467052 01 RESIDUE CHEMISTRY 860.1100 171 2 Chemical Identity 1,3, 4, 7,8,10 41612001 860.1300 171 4 Plant Metabolism 1,3, 4, 7,8,10 Data Gap 860.1300 171 4 Livestock Metabolism 1,3, 4, 7,8,10 Reserved 860.1340 171 4 Residue Analytical Methods Plant Commodities 1,3, 4, 7,8,10 Data Gap 92 DATA REQUIREMENT CITATION( S)

New Guideline Number Old Guideline Number Study Title Use Pattern MRID Number 860.1340 171 4 Residue Analytical Method Livestock 1,3, 4, 7,8,10 Reserved 860.1360 171 4 Multi residue Methods 1,3, 4, 7,8,10 Reserved 860.1380 171 4 Storage Stability Data Plant Commodities 1,3, 4, 7,8,10 Data Gap 860.1380 171 4 Storage Stability Data Processed Commodities 1,3, 4, 7,8,10 Reserved 860.1380 171 4 Storage Stability Data Livestock Commodities 1,3, 4, 7,8,10 Reserved 860.1480 171 4i Meat/ Milk/ Poultry/ Egg 1,3, 4, 7,8,10 Reserved 860.1500 171 4k Crop Field Trials Beat, Sugar, Tops ( Root and Tuber Vegetables Group) 1,3, 4, 7,8,10 Reserved 860.1500 171 4k Crop Field Trials Beet, Sugar, Tops ( Leaves of Root and Tuber Vegetables Group) 1,3, 4, 7,8,10 Reserved 860.1500 171 4k Crop Field Trials Barley, Grain ( Cereal Grains Group) 1,3, 4, 7,8,10 Reserved 860.1500 171 4k Crop Field Trials Oat, Grain ( Cereal Grains Group) 1,3, 4, 7,8,10 Reserved 860.1500 171 4k Crop Field Trials Rice, Grain ( Cereal Grains Group) 1,3, 4, 7,8,10 Reserved 860.1500 171 4k Crop Field Trials Wheat, Grain and Aspirated Grain Fractions ( Cereal Grains Group) 1,3, 4, 7,8,10 Reserved 860.1500 171 4k Crop Field Trials Barley, Hay and Straw ( Fodder, Forage, Hay and Straw of Cereal Grains Group) 1,3, 4, 7,8,10 Reserved 860.1500 171 4k Crop Field Trials Oat, Forage, Hay and Straw ( Fodder, Forage,

Hay and Straw of Cereal Grains Group) 1,3, 4, 7,8,10 Reserved 860.1500 171 4k Crop Field Trials Rice, Straw ( Fodder, Forage, Hay and Straw of Cereal Grains Group) 1,3, 4, 7,8,10 Reserved 860.1500 171 4k Crop Field Trials Wheat, Forage, Hay, and Straw ( Fodder,

Forage, Hay and Straw of Cereal Grains Group) 1,3, 4, 7,8,10 Reserved 860.1500 171 4k Crop Field Trials Cotton, Undelinted Seed and Gin Byproducts ( Miscellaneous Commodities) 1,3, 4, 7,8,10 Reserved 860.1520 171 4l Processed Food/ Feed Barley 1,3, 4, 7,8,10 Data Gap 860.1520 171 4l Processed Food/ Feed Beet, Sugar 1,3, 4, 7,8,10 Data Gap 860.1520 171 4l Processed Food/ Feed Cotton 1,3, 4, 7,8,10 Data Gap 93 DATA REQUIREMENT CITATION( S)

New Guideline Number Old Guideline Number Study Title Use Pattern MRID Number 860.1520 171 4l Processed Food/ Feed Oat 1,3, 4, 7,8,10 Data Gap 860.1520 171 4l Processed Food/ Feed Rice 1,3, 4, 7,8,10 Data Gap 860.1520 171 4l Processed Food/ Feed Safflower 1,3, 4, 7,8,10 Data Gap 860.1520 171 4l Processed Food/ Feed Wheat 1,3, 4, 7,8,10 Data Gap 860.1550 171 6 Proposed Tolerances 1,3, 4, 7,8,10 Data Gap 860.1650 171 13 Submittal of Analytical Reference Standards 1,3, 4, 7,8,10 Data Gap 860.1850 165 1 Confined Rotational Crops 1,3, 4, 7,8,10 Reserved 860.1900 165 2 Field Rotational Crops 1,3, 4, 7,8,10 Reserved OTHER DATA REQUIREMENTS Special Study Special Study Leather Leaching Study 1,3, 4, 7,8,10 Data Gap 94 Appendix C. Technical Support Documents Additional documentation in support of this RED is maintained in the OPP docket, located in Room S 4400, One Potomac Yard, 2777 South Crystal Drive, Arlington, VA, and is open Monday through Friday, excluding legal holidays, from 8: 30 am to 4 pm.

The docket initially contained the April 19, 2006 preliminary risk assessment and the related documents. EPA then considered comments on these risk assessments ( which are posted to the e docket) and revised the risk assessments. The revised risk assessments will be posted in the docket at the same time as the RED.

All documents, in hard copy form, may be viewed in the OPP docket room or downloaded or viewed via the Internet at the following site:

http:// www. regulations. gov These documents include:

  2( Thiocyanomethylthio) benzothiazole ( TCMTB) Risk Assessment ( Phase 3 of 4 Phase Process); Notice of Availability, 4/ 26/ 2006 Preliminary Risk Assessment and Supporting Science Documents:   2( Thiocyanomethylthio) benzothiazole ( TCMTB) Preliminary Risk Assessment for the Reregistration Eligibility Decision ( RED) Document, 04/ 19/ 2006.   TCMTB. Acute and Chronic Dietary Exposure Assessments for the Reregistration Eligibility Decision ( RED) Document, 02/ 28/ 2006. Samuel Ary.   TCMTB. Summary of Analytical Chemistry and Residue Data for the Reregistration Eligibility Decision ( RED) Document, 2/ 28/ 2006. Samuel Ary.   Incident Reports Associated with 2( Thiocyanomethylthio) benzothiazole ( TCMTB), 04/ 18/ 2006. Jonathan Chen.   Environmental Fate Assessment of 2( Thiocyanomethylthio) benzothiazole ( TCMTB) for the Reregistration Eligibility Decision ( RED) Document, 03/ 30/ 2006. Srinivas Gowda.   Product Chemistry Science Chapter for 2( Benzpthiazolylthio) methly thiocyanate, 03/ 31/ 2006. Chris Jiang.   Drinking Water Assessment for the Use of the Fungicide of 2 ( Thiocyanomethylthio) benzothiazole ( TCMTB) as a Seed Treatment on Cotton, Wheat, Barley, Oats, Rice, Sugar Beets, and Safflower, 07/ 31/ 2006. James Lin.   Aquatic Exposure Assessment for the Use of the Fungicide of 2 ( Thiocyanomethylthio) benzothiazole ( TCMTB) as a Seed Treatment on Cotton, Wheat, Barley, Oats, Rice, Sugar Beets, and Safflower, 02/ 16/ 2006. James Lin   2( Thiocyanomethylthio) benzothiazole ( TCMTB) Report of the Antimicrobials Division Toxicity Endpoint Selection Committee ( ADTC), 04/ 19/ 2006. Timothy F. McMahon.   2( Thiocyanomethylthio) benzothiazole ( TCMTB) Ecological Hazard and Environmental Risk Characterization and Environmental Modeling Chapters for the Reregistration Eligibility Decision ( RED) Document ( D322613), Edited per Phase I Error Correction 95 Comments and Revised ESA Language, 04/ 06/ 2006. Kathryn Montague.   TCMTB [ 2( Thiocyanomethylthio) benzothiazole]: First Revision of the Occupational and Residential Exposure Assessment for the Reregistration Eligibility Decision Document. 04/ 06/ 2006, Charles Smith.   Toxicology Disciplinary Chapter for the Reregistration Eligibility Decision ( RED) Risk Assessment, 04/ 04/ 2006. Deborah Smegal.   Occupational and Residential Exposure Assessment for 2 ( Thiocyanomethylthio) benzothiazole TCMTB, 04/ 18/ 2006. Siroos Mostaghimi.

Revised Risk Assessment and Supporting Science Documents ( RED Supporting Documents):   2( Thiocyanomethylthio) benzothiazole ( TCMTB) Risk Assessment for the Reregistration Eligibility Decision ( RED) Document, 08/ 01/ 2006.   2( Thiocyanomethylthio) benzothiazole ( TCMTB) Ecological Hazard and Environmental Risk Assessment Chapter Revised, 08/ 01/ 2006. Kathryn Montague   TCMTB [ 2( Thiocyanomethylthio) benzothiazole]: Second Revision of the Occupational and Residential Exposure Assessment for the Reregistration Eligibility Decision Document, 07/ 27/ 2006. Charles Smith 96 Appendix D. Citations Considered to be Part of the Data Base Supporting the Reregistration Decision ( Bibliography)

1. MRID Studies MRID# Citation 00004239 Wilbur Ellis Company ( 1979) Residue Data Summary. Unpublished study including letter dated Oct 16, 1978 from J. H. Stoner to Dave T. Schulteis, received Feb 6, 1979 under 2935 413; pre pared in cooperation with Stoner Laboratories; CDL: 237334 A 00004241 Wilbur Ellis Company ( 1979) Results of Tests on the Amount of Resi due Remaining, Including a Description of the Analytical Method: Nu Flow ND. Unpublished study received Feb 6, 1979 under 2935 413; CDL: 237335 B.

00046073 Buckman Laboratories, Incorporated ( 1975) Analytical Procedures and Results of Residue Analyses: Busan 30. Undated method. Unpublished study received Nov 12, 1976 under 7F1885; CDL: 095601 D.

00078556 Buckman Laboratories, Incorporated ( 1972) Analytical Procedures and Results of Residue Analyses: Busan 30. Includes undated methods entitled: Analyses of 2( thiocyanomethylthio) benzothiazole in soil; Regulatory method of analysis. Unpublished study re ceived Mar 26, 1975 under 4F1613; CDL: 095525 F.

00112618 Buckman Laboratories, Inc. ( 1970) Results of Tests on the Amount of Residue Remaining, Including a Description of the Analytical Method: 2 ( Thiocyanomethylthio) benzothiazole. Compilation; unpublished study received on unknown date under 0F0954; CDL: 091624 K.

00117874 Buckman Laboratories, Inc. ( 1967) Study: TCMTB Residues in Selected Grains). ( Compilation; unpublished study received Sep 28, 1972 under 2F1264; CDL: 091795 A.

00124027 Buckman Laboratories, Inc. ( 19??) Analysis of Grains for Thioben zothiazole Containing Residues. Unpublished study received Oct 20, 1972 under 2F1264; CDL: 094858 A.

00136342 Buckman Laboratories, Inc. ( 19??) Analysis of Grains for Thioben zothiazole Containing Residues. Unpublished study received on unknown date under 2F1264; CDL: 097967 A. 97 MRID# Citation 00138078 Buckman Laboratories, Inc. ( 1975) Residue Data: Busan 30: Sugar Cane. Unpublished study received Nov 12, 1976 under 7F1885; CDL: 097566 B.

00154295 Goad P. T., et al. 1985. Teratogenicity study of TCMTB in rats. HED Doc no. 005769.

165518 Bonner, G. ( 1986) Evaluation of Other Genotoxic Effects TCMTB ( EPA Reg. No.: 1448 29): In the Rat Primary Hepatocyte Unscheduled DNA Synthesis Assay: HBC Project No. 20991. Unpublished study prepared by Hazleton Biotechnologies Company. 21 p.

165520 Bonner, G. ( 1986) Evaluation for Structural Chromosomal Aberration of TCMTB ( EPA Reg. No.: 1448 29): Clastogenic Evaluation in the in vivo Mouse Micronucleus Assay: HBC Project No. 20996. Unpublished study prepared by Hazleton Biotechnologies Co. 23 p.

009869 Booden, R. M. 1974. Avian Dietary LC50, Mallard Duck, Report # 4043620. Unpublished data, conducted by Warf Institute for Buckman Laboratories, Memphis, TN.

091624 Knott, W. B., and G. Woodard. 1968a. Busan 72   Safety Evaluation on Bobwhite Quail. Unpublished data, conducted by Woodard Research Corp., for Buckman Laboratories, Inc., Memphis, TN.

091624 Knott, W. B., and G. Woodard. 1968b. Busan 72   Safety Evaluation on Bluegill Sunfish and Rainbow Trout. Unpublished data, conducted by Woodard Research Corp., for Buckman Laboratories, Inc., Memphis, TN 400751 01 Adam, C. P. 1986. TCMTB  A teratology study in rabbits.

400751 02 Adam, C. P. 1986. TCMTB  A teratology study in rabbits.

403636 01 Surprenant, D. C. 1986a. Acute Toxicity of TCMTB to the Sheepshead Minnow, Cyprinodon variegatus. Unpublished data, conducted by Springborn Bionomics, Inc., for Buckman Laboratories, Inc., Memphis, TN 403363 02 Surprenant, D. C. 1987. Acute Toxicity of TCMTB to Mysid Shrimp ( Mysidopsis bahia). Unpublished data, conducted by Springborn Bionomics, Inc., for Buckman Laboratories, Inc., Memphis, TN. 98 MRID# Citation 403636 03 Surprenant, D. C. 1986b. Acute Toxicity of TCMTB to Embryo Larvae of the Quahog Clam ( Mercenaria mercenaria). Unpublished data, conducted by Springborn Bionomics, Inc., for Buckman Laboratories, Inc., Memphis, TN. 404193 01 Buckman Laboratories, Inc. ( 1987) Submission of Toxicity Data on TCMTB in support of EPA Reg. No. 1448 29. Transmittal of 1 study.

408848 01 Cameron, B. D. Scott, G. 1987. The Metabolism of 2 ( Thiocyanomethylthio) benzothiazole ( TCMTB) in the rat. Buckman Laboratories, Inc., Memphis TN. Inveresk Research International Ltd., Scotland 413422 01 Goburdhun, R., and Greenough, R. J. 1989. 2 ( Thiocyanomethylthio) benzothiazole ( TCMTB): 52 Week dietary toxicity study in dogs.

413861 01 Lawlor, T.; Respess, C. ( 1990) Mutagenicity Test on TCMTB in the Salmonella/ Mammalian microsome Reverse Mutation Assay ( Ames Test) with Confirmatory Assay: Final Report: Lab Project I. D.: 110277 0 401R. Unpublished study prepared by Hazleton Labora tories America, Inc. 32p.

414714 01 Hazelden, K., Pl. and Wilson, J. A. 1988. TCMTB Two generation reproduction study in rats. HED Doc 010607 415154 01 Hazleton Institut Francais de Toxicologie ( 1990) TCMTB Technical Grade: Acute Dermal Median Lethal Dose: Lab Project Number: 410211. 48 p.

415157 01 Saxena, A. ( 1987) Artificial Sunlight Photodegradation of TCMTB in a Buffered Aqueous Solution: Lab Project Number: HLA 6015 335. Unpublished study prepared by Hazleton Laboratories America, Inc. 86 p.

415297 01 Everett, D. J. et al. 1989. 104 Week dietary toxicity/ carcinogenicity study n rats with 52 week interim kill.

415703 01 Everett, D. J. et al. 1989. 104 Week dietary toxicity/ carcinogenicity study n rats with 52 week interim kill.

415837 01 Rush, R. ( 1990) Primary Skin Irritation Study in Rabbits with TCMTB  80 (...): Lab Project Number: 3138.61. Unpublished study pre pared by Springborn Laboratories, Inc. 20 p. 99 MRID# Citation 415838 01 Rush, R. ( 1990) Acute Oral Toxicity Study in Rats with TCMTB 80 (.. .): Lab Project Number: 3138.59. Unpublished study prepared by Springborn Laboratories, Inc. 63 p.

415956 01 Long, R. D., C. P. Driscoll, K. A. Hoxter, and G. J. Smith. 1990. TCMTB: A Dietary LC50 Study with the Mallard. Unpublished data, conducted by Wildlife International, Ltd., for Buckman Laboratories, Inc., Memphis, TN.

415956 02 Long, R. D., C. P. Driscoll, K. A. Hoxter, and G. J. Smith. 1990. TCMTB: A Dietary LC50 Study with the Northern Bobwhite. Unpublished data, conducted by Wildlife International, Ltd., for Buckman Laboratories, Inc., Memphis, TN.

416120 01 Fues, R.; Conaway, L.; Bowles, D. ( 1990) Product Chemistry for TCMTB: Product Identity; Manufacturing Process; Discussion of Impurities|. Unpublished study prepared by Buckman Laboratories International, Inc. 55 p.

416120 02 Fues, R.; Conaway, L.; Bowles, D. ( 1990) Product Chemistry for TCMTB: Preliminary Analysis; Certified Limits; Enforcement Ana lytical Techniques|: Lab Project Number: 101 01. Unpublished study prepared by Buckman Laboratories International, Inc. 51 p.

416120 03 Bowles, D. ( 1990) Product Chemistry for TCMTB: ( Physical/ Chemical Properties). Unpublished study prepared by Buckman Laboratories International, Inc. 89 p.

416558 01 Siglin, J. ( 1990) 21 Day Dermal Toxicity Study in Rats with TCMTB 80: Final Report: Lab Project Number: 3138.53. Unpublished stu dy prepared by Springborn Laboratories, Inc. 274 p.

417809 01 Campbell, S. 1991. TCMTB: An Acute Oral Toxicity Study with the Northern Bobwhite." Unpublished data, conducted by Wildlife International, Ltd., for Buckman Laboratories, Memphis, TN 418042 01 Machado, M. W. 1991a. TCMTB   Acute Toxicity to Bluegill Sunfish ( Lepomis macrochirus) under Flow through Conditions. Unpublished data, conducted by Springborn Laboratories, Inc., for Buckman Laboratories, Inc., Memphis, TN. 100 MRID# Citation 418181 01 Machado, M. W. 1991b. TCMTB   Acute Toxicity to Rainbow Trout ( Oncorhynchus mykiss) Under Flow Through Conditions. Unpublished data, conducted by Springborn Laboratories, Inc., for Buckman Laboratories, Inc., Memphis, TN 418382 01 McNamara, P. C. 1991. TCMTB   Acute Toxicity to Daphnids ( Daphnia magna) Under Flow Through Conditions. Unpublished data, conducted by Springborn Laboratories, Inc, for Buckman Laboratories, Inc., Memphis, TN.

420597 01 Watson, C. ( 1991) Product Chemistry for TCMTB. Unpublished study prepared by Buckman Labs International, Inc. 37 p.

4211653 01 Everett, D. J. et al. 1989. 104 Week dietary toxicity/ carcinogenicity study n rats with 52 week interim kill.

422260 01 Collins, M. K. 1992b. 2 Mercaptobenzothiazole ( ROKON)   Acute Toxicity to Daphnids ( Daphnia magna) Under Static Conditions. Unpublished data, conducted by Springborn Laboratories, Inc., for R. T. Vanderbilt Ct., Inc., Norwalk, CT.

422322 01 Collins, M. K. 1992a. 2 Mercaptobenzothiazole ( ROKON)   Acute Toxicity to Rainbow Trout ( Oncorhynchus mykiss) Under Static Conditions. Unpublished data, conducted by Springborn Laboratories, Inc., for R. T. Vanderbilt Ct., Inc., Norwalk, CT 422671 01 Pedersen, C. A., and B. R. Helsten. 1992a. 2 Mercaptobenzothiazole ( ROKON): 14 day Acute Oral LD50 Study in Bobwhite Quail. Unpublished data, conducted by Bio Life Associates, Ltd., for R. T. Vanderbilt Co., Inc., Norwalk, CT.

423245 01 Whetzel, J. ( 1992) Determination of the Octanol/ Water Partition Coefficient of TCMTB: Lab Project Number: 94/ 91 BUC. 24. Un published study prepared by Twin City Testing Corp. 30 p.

423492 01 Karcher, R.; Siglin, J.; Becci, P. ( 1986) Delayed Contact Hypersensitivity Study in Guinea Pigs with HPMTS: Lab Project Number: 3138.7. Unpublished study prepared by Springborn Institute for Bioresearch, Inc. 55 p.

423768 01 Raub, M.; Valle, H. ( 1992) Uptake and Translocation of carbon 14| Busan 30A Used in Seed Treatment: Combustion Analysis Phase: Lab Project Number: 39601. Unpublished study prepared by ABC Labs, Inc. 34 p. 101 MRID# Citation 423833 01 Everett, D. J., et al. 1990. 2( Thiocyanomethylthio) benzothiazole 104 Week 423861 01 Fathulla, R. N. 1992. Hydrolysis of 14C TCMTB in Aqueous Buffer Solutions. Unpublished data. Conducted by Hazleton Wisconsin, Inc. for Buckman Laboratories International, Inc.

424074 01 Whetzel, J. ( 1992) Determination of the Boiling Point of TCMTB: Supp.|: Lab Project Number: 1002 001. Unpublished study prepared by Twin City Testing Corp. 19 p.

424185 01 Blasberg, J. W., S. L. Hicks and L. S. Stuerman. 1992. Uptake, Depuration, and Bioconcentration of 14C TCMTB by Bluegill Sunfish Lepomis macrochirus. Unpublished data. Conducted by ABC Laboratories, Inc. for Buckman Laboratories International, Inc.

424285 01 Pedersen, C. A., and B. R. Helsten. 1992b. 2 Mercaptobenziothiazol ( ROKON): 8 Day Acute Dietary LC50 Study in Bobwhite Quail. Unpublished data, conducted by Bio Life Associates, Ltd., for R. T. Vanderbilt Co., Norwalk, CT.

424932 01 Falb, L. And Stewart, R. C. 1992. Metabolism of [ 14C] TCMTB in Water and Fish Tissue. Unpublished data. Conducted by ABC Laboratories, Inc. for Buckman Laboratories International, Inc.

425086 01 Fathulla, R. N. 1992. Aerobic Aquatic Metabolism of TCMTB. Unpublished data. Conducted by Hazleton Wisconsin, Inc. for Buckman Laboratories International, Inc.

425929 01 Rhodes, J. E. 1992. Early Life Stage Toxicity of 2 ( Thiocyanomethylthio) benzothiazole ( TCMTB) to the Rainbow Trout Under Flow Through Conditions. Unpublished data, conducted b ABC Laboratories, Inc., for Buckman Laboratories International, Inc., Memphis, TN.

426309 01 Fathulla, R. N. 1993. Artificial Sunlight Photodegradation of 14C TCMTB in an Aqueous Buffer Solution. Unpublished data. Conducted by Hazleton Wisconsin, Inc. for Buckman Laboratories International, Inc.

426314 01 Fathulla, R. N. 1992. The Adsorption and Desorption of 14C TCMTB on Representative Agricultural Soils. Unpublished data. Conducted by Hazleton Wisconsin, Inc. for Buckman Laboratories International, Inc. 102 MRID# Citation 428154 01 Fathuella, R. N. 1993. Anaerobic Aquatic Metabolism of 14C TCMTB. Unpublished data. Conducted by Hazleton Wisconsin, Inc. for Buckman Laboratories International, Inc.

43112801 Atkinson, C., et al. 1987. 2( Thiocyanomethylthio) benzothiazole ( TCMTB). 13 Week dietary dose range finding study in rats.

431472 01 Raub, M. ( 1994) Uptake and Translocation of ( carbon 14) Busan 30A Used in Seed Treatment: Addendum Report: Lab Project Number: 39601A. Unpublished study prepared by ABC Labs., Inc. 13 p.

434376 01 Lowrie, C. 1994. Hydrolysis of ( cyano( 14C)) TCMTB in Aqueous Buffer Solution. Unpublished data. Conducted by Hazleton Wisconsin, Inc. for Buckman Laboratories International, Inc.

435322 01 Fathulla, R. N. 1994. Aerobic Soil Metabolism of 14C TCMTB. Unpublished data. Conducted by Hazleton Wisconsin, Inc. for Buckman Laboratories International, Inc.

441198 02 Duguet J. S. and V. Dartigues. 1988. Evaluating Possibilities of Leaching of Deltamethrin and TCMB ( Insecticide and Fungicide for Protecting Wood) by Rain Water or by Soaking in Water. Unpublished data. Conducted by IRG Secretariat, Sweden for AgrEvo Environmental Health.

442009 01 Thompson, S. G., and J. P. Swigert. 1996. TCMTB: A 14 Day Static Renewal Toxicity Test with Duckweed ( Lemna gibba). Unpublished data, conducted by Wildlife International, Ltd., for Buckman Laboratories International, Inc., Memphis, TN.

445013 01 Singer, G. ( 1998) Nature of the Residue from ( carbon 14) TCMTB in/ on Tomatoes after Soil Drench Applications: Final Report: Lab Project Number: AA960317: XBL96101. Unpublished study prepared by American Agricultural Services, Inc. and XenoBiotic Labs. 26 p.

445013 02 Singer, G. ( 1998) Nature of the Residue from ( carbon 14) TCMTB in/ on Melons after Soil Drench Applications: Final Report: Lab Project Number: AA960318: XBL96101. Unpublished study prepared by American Agricultural Services, Inc. and XenoBiotic Labs. 26 p. 103 MRID# Citation 446541 01 Singer, G. ( 1998) Nature of the Residue from ( carbon 14) TCMTB in/ on Melons after Soil Drench Applications: Final Report: Lab Project Number: AA960318: XBL96101: AA960318. NC. Unpublished study prepared by American Agricultural Services, Inc. and XenoBiotic Laboratories. 268 p.

446541 02 Singer, G. ( 1998) Nature of the Residue from ( carbon 14) TCMTB in/ on Tomatoes after Soil Drench Applications: Final Report: Lab Project Number: XBL96101: AA960317. Unpublished study prepared by American Agricultural Services, Inc. and XenoBiotic Laboratories. 257 p.

455243 04 Bestari KT, Macey K, Soloman KR, Tower N. 1999. Measurement and Assessment of Dermal and Inhalation Exposures to Didecyl Dimethyl Ammonium Chloride ( DDAC) Used in the Protection of Cut Lumber ( Phase III).

467052 01 Blasberg, J. W., S. L. Hicks and L. S. Stuerman. 1992. Uptake, Depuration, and Bioconcentration of 14C TCMTB by Bluegill Sunfish Lepomis macrochirus. Unpublished data. Conducted by ABC Laboratories, Inc. for Buckman Laboratories International, Inc. Supplemental Information in Response to Chris Jiang's DERs for Bioaccumulation Study of TCMTB MRID Nos. 424185 01 & 424932 01.

467110 01 Byrne, A. and D. R. Minchin. ( 1989) Leaching of TCMTB from Packaged Lumber. Prepared for Buckman Laboratories of Canada by Forintex Canada Corporation, Western Region, 6620 N. W. Marine Drive, Vancouver, B. C. V6T 1X2. Contract No. 17 86 K 409.

467111 01 Beck, Maureen; Hartmann, FE; May, JH; Reid, TC. 1996. Leachability Study . ( leaching of TCMTB from wood blocks). Buckman Laboratories, Inc., Memphis, TN. Control no. 452779. dietary carcinogenicity study in mice. HED Doc. 010332.

92179008 Goburdhun, R., and Greenough, R. J. 1989. 2 ( Thiocyanomethylthio) benzothiazole ( TCMTB): 52 Week dietary toxicity study in dogs.

92179009 Goad P. T., et al. 1985. Teratogenicity study of TCMTB in rats. HED Doc no. 005769.

92179011 Adam, C. P. 1986. TCMTB  A teratology study in rabbits. 104 MRID# Citation 92179011 Hazelden, K., Pl. and Wilson, J. A. 1988. TCMTB Two generation reproduction study in rats. HED Doc 010607 92179026 Rao, G., No. 1980. 90 Day subchronic oral toxicity study of TCMTB in rats 2. Open Literature Chew, G. L., G. M. Kruzynski, and I. K. Birtwell. Behavioral assessment of exposure of juvenile Chinook salmon ( Oncorhynchus tshawtscha) to sublethal doses of a toxicant. In Proceedings of the Seventeenth Annual Aquatic Toxicity Workshop, Nov. 5 7, 1990, Vancouver, BC, Vol. 1. ( edited by P. Chapman, F. Bishay, E. Power, K. Hall, L. Harding, D. Mcleay, M. Nassichuk and W. Knapp). Canadian Technical report of Fisheries and Aquatic Sciences, No. 1774 ( vol 1).

Freeman, N , Jimenez M, Reed KJ, Gurunathan S, Edwards RD, Roy A, Adgate JL, Pellizzari ED, Quackenboss J, Sexton K, Lioy PJ, 2001. Quantitative analysis of chilren's microactivity patterns: The Minnesota Children's Pesticide Exposure Study. Journal of Exposure Analysis and Environmental Epidemiology. 11( 6): 501 509.

HERA, 2005. Human and Environmental Risk Assessment, Guidance Document Methodology, February 2005 ( http:// www. heraproject. com). The Multi Chamber Concentration and Exposure Model ( MCCEM) Model Version 1.2. Prepared for the US EPA Office of Pollution Prevention and Toxics. Prepared by Versar, Inc. and Wilkes Technologies, LLC.

Karickhoff SW, DS Brown, TA Scott, 1979. Sorption of Hydrophobic Pollutants on Natural Sediments. Water Resources. 13: 241 248.

Krahn P and Strub R, 1990. Standard Leaching Test for Antisapstain Chemicals: Regional Program Report 90 10. Environment Canada, Conservation and Protection, Pacific and Yukon Region North Vancouver, BC.

Kruzynski, G. M., and I. K. Birtwell. 1990. Some Respiratory Responses of Juvenile Pacific Salmon to the Antisapstain Chemical TCMTB. Proceedings of the Seventeenth Annual Aquatic Toxicity Workshop, Nov. 5 7, 1990, Vancouver, BC, Vol. 1. ( edited by P. Chapman, F. Bishay, E. Power, K. Hall, L. Harding, D. Mcleay, M. Nassichuk and W. Knapp). Canadian Technical report of Fisheries and Aquatic Sciences, No. 1774 ( vol 1).

Kruzynski, G. M., I. K. Birtwell, G. L. Chew, G. E. Piercey, and S. Spohn. 1990. An approach to testing for ecological relevance using behavioral toxicology. Proceedings of the Seventeenth Annual Aquatic Toxicity Workshop, Nov. 5 7, 1990, Vancouver, BC, Vol. 1. ( edited by P. Chapman, F. Bishay, E. Power, K. Hall, L. Harding, D. Mcleay, M. 105 Nassichuk and W. Knapp). Canadian Technical report of Fisheries and Aquatic Sciences, No. 1774 ( vol 1).

Manninen, A., Auriola S, Vartiainen M., Leisivuori J., Turunen, T., Pasanen M. 1996. Determination of urinary 2 mercaptobenzothiazole ( 2 MBT), the main metabolite of 2( thiocyanomethylthio) benzothiazole ( TCMTB) in humans and rats.

Mineau, P., B. T. Collins, and A. Baril. 1996. On the Use of Scaling Factors to Improve Interspecies Extrapolation of Acute Toxicity in Birds. Regul Toxicol Pharmacol 24; 24 29.

USDA's Continuing Surveys of Food Intakes by Individuals ( CSFII), 1994 1996 and 1998.

3. Website References Aschacher G and Gruendlinger R, 2000. Methods to evaluate the ecotoxicological risks of antisapstain preservatives. Holzforschung, Austria Research and Development. www. holzforschung. at/ english/ img_ eng/ ascha200. pdf Addinsoft, 2004. XLSTAT v7.5. http:// www. xlstat. com Do It Yourself, 2005. What You Need to Know When Carpet Shopping. http:// doityourself. com/ carpet/ carpetshopping. htm. ( September 2005).

FIRST ( version 1.0; Aug. 1, 2001) Screening Model. http:// www. epa. gov/ oppefed1/ models/ water/

Terrestrial Residue Exposure Model ( TREX). ( http:// www. epa. gov/ oppefed1/ models/ terrestrial).

Tier 1 models: GENEEC ( version 2.0; Aug. 1, 2001) and SCI GROW ( version 2.3; Nov. 4, 2003) screening models. http:// www. epa. gov/ oppefed1/ models/ water/.

USEPA. 2000. Information on Assessing Exposure from Pesticides, " A User's Guide." http:// www. epa. gov/ fedrgstr/ EPA PEST/ 2000/ July/ Day 12/ 6061. pdf USEPA. 2004. PBT Profiler: Assessing Chemicals in the Absence of Data, v1.203. http:// www. pbtprofiler. net/ default. asp. ( January 2006).

4. Internal Documents and Models USEPA. 1979. TN 2432. Biological Report of Analysis, 90+ TCMTB, sample MB618. Unpublished data, performed by US EPA Terrestrial and Aquatic Biology Laboratory.

USEPA. 1979. TN 2427. Biological Report of Analysis, 90+ TCMTB, sample MB618. 106 Unpublished data, performed by US EPA Terrestrial and Aquatic Biology Laboratory.

USEPA. 1980. TN 2437. Biological Report of Analysis, 90+ TCMTB, sample MB618. Unpublished data, performed by US EPA Terrestrial and Aquatic Biology Laboratory.

USEPA. 1997. Exposure Factors Handbook. Volume I II. Office of Research and Development. Washington, D. C. EPA/ 600/ P 95/ 002Fa. August 1997.

USEPA. 1998. PHED Surrogate Exposure Guide. Estimates of Worker Exposure from the Pesticide Handler Exposure Database Version 1.1. Washington, DC: U. S. Environmental Protection Agency.

USEPA. 1999. Evaluation of Chemical Manufacturers Association Antimicrobial Exposure Assessment Study ( Amended on 8 December 1992). Memorandum from Siroos Mostaghimi, PH. D., USEPA to Julie Fairfax, USEPA. Dated November, 4 1999. DP Barcode D247642.

USEPA. 2000. Residential SOPs. EPA Office of Pesticide Programs Human Health Effects Division. Dated April 5, 2000.

USEPA. 2000. Information on Assessing Exposure from Pesticides, " A User's Guide." http:// www. epa. gov/ fedrgstr/ EPA PEST/ 2000/ July/ Day 12/ 6061. pdf USEPA. 2001. HED Science Advisory Council for Exposure. Policy Update, November 12. Recommended Revisions to the Standard Operating Procedures ( SOPs) for Residential Exposure Assessment, February 22, 2001.

USEPA, March 2, 2004. Health Effects Division Science Advisory Committee on Exposure ( HED ExpoSAC) SOP # 15: " Amount of Seed Treated or Planted per Day."

USEPA. 2004. WLM recommendation regarding chemical generalization. Memorandum to Siroos Mostaghimi, from Lee R. December 15, 2004.

USEPA. 2004. Overview of the Ecological Risk Assessment Process in the Office of Pesticide Programs U. S. Environmental Protection Agency  Endangered and Threatened Species Effects Determinations, January 23, 2004.

USEPA, 2004. Wood Leaching Model: Chemical Concentration Screening Tool, v1.0. USEPA/ OPPT/ AD, developed by Versar, Inc.

USEPA. 2004. PBT Profiler: Assessing Chemicals in the Absence of Data, v1.203. http:// www. pbtprofiler. net/ default. asp. ( January 2006).

USEPA. 2006. 2( thiocyanomethylethylthio) benzothaizole ( TCMTB) report of the 107 Antimicrobials Division Toxicity Endpoint Selection Committee ( ADTC). Memorandum from Timothy McMahon to Deborah Smegal. April 4, 2006.

USEPA. 2006. Office of Pesticide Programs internal memorandum, " Aquatic Exposure Assessment for the Use of the Fungicide of 2( Thiocyanomethylthio) benzothiazole ( TCMTB) as a Seed Treatment on Cotton, Wheat, Barley, Oats, Rice, Sugar Beets, and Safflower," February 16, 2006.

USEPA. 1/ 11/ 2006. Deschamp, P," Report of the RARC."

Dietary Exposure Evaluation Model Software with the Food Commodity Intake Database ( DEEM FCID   , Version 2.03).

FDA Center for Food Safety & Applied Nutrition's ( CFSAN), 4/ 2002. " Preparation of Food Contact Notifications and Food Additive Petitions for Food Contact Substances: Chemistry Recommendations."

FIRST ( version 1.0; Aug. 1, 2001) Screening Model. http:// www. epa. gov/ oppefed1/ models/ water/ .

Terrestrial Residue Exposure Model ( TREX) ( http:// www. epa. gov/ oppefed1/ models/ terrestrial).

Tier 1 models: GENEEC ( version 2.0; Aug. 1, 2001) and SCI GROW ( version 2.3; Nov. 4, 2003) screening models. http:// www. epa. gov/ oppefed1/ models/ water/. 108 Appendix E. Generic Data Call In The Agency intends to issue a Generic Data Call In at a later date. See Chapter V of the TCMTB RED for a list of studies that the Agency plans to require. 109 Appendix F. Product Specific Data Call In The Agency intends to issue a Product Specific Data Call In at a later date. 110 Appendix G. Batching of TCMTB Products for Meeting Acute Toxicity Data Requirements for Reregistration The Agency will complete the batching for TCMTB at a later date. 111 Appendix H. List of All Registrants Sent the Data Call In A list of registrants sent the data call in will be posted at a later date. 112 Appendix I. List of Available Related Documents and Electronically Available Forms Pesticide Registration Forms are available at the following EPA internet site: http:// www. epa. gov/ opprd001/ forms/ .

Pesticide Registration Forms ( These forms are in PDF format and require the Acrobat reader)

Instructions 1. Print out and complete the forms. ( Note: Form numbers that are bolded can be filled out on your computer then printed.)

2. The completed form( s) should be submitted in hardcopy in accord with the existing policy.

3. Mail the forms, along with any additional documents necessary to comply with EPA regulations covering your request, to the address below for the Document Processing Desk.

DO NOT fax or e mail any form containing ` Confidential Business Information' or ` Sensitive Information.'

If you have any problems accessing these forms, please contact Nicole Williams at ( 703) 308 5551 or by e mail at williams. nicole@ epamail. epa. gov.

The following Agency Pesticide Registration Forms are currently available via the internet at the following locations: 8570 1 Application for Pesticide Registration/ Amendment http:// www. epa. gov/ opprd001/ forms/ 8570 1. pdf 8570 4 Confidential Statement of Formula http:// www. epa. gov/ opprd001/ forms/ 8570 4. pdf 8570 5 Notice of Supplemental Registration of Distribution of a Registered Pesticide Product http:// www. epa. gov/ opprd001/ forms/ 8570 5. pdf 8570 17 Application for an Experimental Use Permit http:// www. epa. gov/ opprd001/ forms/ 8570 17. pdf 8570 25 Application for/ Notification of State Registration of a Pesticide To Meet a Special Local Need http:// www. epa. gov/ opprd001/ forms/ 8570 25. pdf 8570 27 Formulator's Exemption Statement http:// www. epa. gov/ opprd001/ forms/ 8570 27. pdf 8570 28 Certification of Compliance with Data Gap Procedures http:// www. epa. gov/ opprd001/ forms/ 8570 28. pdf 8570 30 Pesticide Registration Maintenance Fee Filing http:// www. epa. gov/ opprd001/ forms/ 8570 30. pdf 8570 32 Certification of Attempt to Enter into an Agreement with other Registrants for Development of Data http:// www. epa. gov/ opprd001/ forms/ 8570 32. pdf 8570 34 Certification with Respect to Citations of Data ( in PR Notice 98 5) http:// www. epa. gov/ opppmsd1/ PR_ Notices/ pr98 5. pdf 8570 35 Data Matrix ( in PR Notice 98 5) http:// www. epa. gov/ opppmsd1/ PR_ Notices/ pr98 5. pdf 8570 36 Summary of the Physical/ Chemical Properties ( in PR Notice 98 1) http:// www. epa. gov/ opppmsd1/ PR_ Notices/ pr98 1. pdf 8570 37 Self Certification Statement for the Physical/ Chemical Properties ( in PR Notice 98 1) http:// www. epa. gov/ opppmsd1/ PR_ Notices/ pr98 1. pdf 113 Pesticide Registration Kit www. epa. gov/ pesticides/ registrationkit/.

Dear Registrant:

For your convenience, we have assembled an online registration kit that contains the following pertinent forms and information needed to register a pesticide product with the U. S. Environmental Protection Agency's Office of Pesticide Programs ( OPP):

1. The Federal Insecticide, Fungicide, and Rodenticide Act ( FIFRA) and the Federal Food, Drug and Cosmetic Act ( FFDCA) as Amended by the Food Quality Protection Act ( FQPA) of 1996.

2. Pesticide Registration ( PR) Notices a. 83 3 Label Improvement Program  Storage and Disposal Statements b. 84 1 Clarification of Label Improvement Program c. 86 5 Standard Format for Data Submitted under FIFRA d. 87 1 Label Improvement Program for Pesticides Applied through Irrigation Systems ( Chemigation)

e. 87 6 Inert Ingredients in Pesticide Products Policy Statement f. 90 1 Inert Ingredients in Pesticide Products; Revised Policy Statement g. 95 2 Notifications, Non notifications, and Minor Formulation Amendments h. 98 1 Self Certification of Product Chemistry Data with Attachments ( This document is in PDF format and requires the Acrobat reader.)

Other PR Notices can be found at http:// www. epa. gov/ opppmsd1/ PR_ Notices.

3. Pesticide Product Registration Application Forms ( These forms are in PDF format and will require the Acrobat reader.)

a. EPA Form No. 8570 1, Application for Pesticide Registration/ Amendment b. EPA Form No. 8570 4, Confidential Statement of Formula c. EPA Form No. 8570 27, Formulator's Exemption Statement d. EPA Form No. 8570 34, Certification with Respect to Citations of Data e. EPA Form No. 8570 35, Data Matrix 114 4. General Pesticide Information ( Some of these forms are in PDF format and will require the Acrobat reader.)

a. Registration Division Personnel Contact List b. Biopesticides and Pollution Prevention Division ( BPPD) Contacts c. Antimicrobials Division Organizational Structure/ Contact List d. 53 F. R. 15952, Pesticide Registration Procedures; Pesticide Data Requirements ( PDF format)

e. 40 CFR Part 156, Labeling Requirements for Pesticides and Devices ( PDF format)

f. 40 CFR Part 158, Data Requirements for Registration ( PDF format)

g. 50 F. R. 48833, Disclosure of Reviews of Pesticide Data ( November 27, 1985)

Before submitting your application for registration, you may wish to consult some additional sources of information. These include:

1. The Office of Pesticide Programs' Web Site 2. The booklet " General Information on Applying for Registration of Pesticides in the United States", PB92 221811, available through the National Technical Information Service ( NTIS) at the following address:

National Technical Information Service ( NTIS) 5285 Port Royal Road Springfield, VA 22161 The telephone number for NTIS is ( 703) 605 6000. Please note that EPA is currently in the process of updating this booklet to reflect the changes in the registration program resulting from the passage of the FQPA and the reorganization of the Office of Pesticide Programs. We anticipate that this publication will become available during the Fall of 1998.

3. The National Pesticide Information Retrieval System ( NPIRS) of Purdue University's Center for Environmental and Regulatory Information Systems. This service does charge a fee for subscriptions and custom searches. You can contact NPIRS by telephone at ( 765) 494 6614 or through their Web site.

4. The National Pesticide Telecommunications Network ( NPTN) can provide information on active ingredients, uses, toxicology, and chemistry of pesticides. You can contact NPTN by telephone at ( 800) 858 7378 or through their Web site: ace. orst. edu/ info/ nptn.

The Agency will return a notice of receipt of an application for registration or amended registration, experimental use permit, or amendment to a petition if the applicant or petitioner 115 encloses with his submission a stamped, self addressed postcard. The postcard must contain the following entries to be completed by OPP:

Date of receipt EPA identifying number Product Manager assignment Other identifying information may be included by the applicant to link the acknowledgment of receipt to the specific application submitted. EPA will stamp the date of receipt and provide the EPA identifying File Symbol or petition number for the new submission. The identifying number should be used whenever you contact the Agency concerning an application for registration, experimental use permit, or tolerance petition. To assist us in ensuring that all data you have submitted for the chemical are properly coded and assigned to your company, please include a list of all synonyms, common and trade names, company experimental codes, and other names which identify the chemical ( including " blind" codes used when a sample was submitted for testing by commercial or academic facilities). Please provide a CAS number if one has been assigned.