12.3
                                                                           1.73

                                     Total
                                                                           99.9
                                                                            100
                                                                           99.9
                                                                            100
                                                                            100
                                                                           0.06

*<LOQ  -  3 x background
**<LOD  -  1 x background
N.S. no sample

Table 19.  Concentration of DIPE equivalents (ug/g) in Tissues Following Repeat Inhalation Exposure of Female F344 Rats to 3600 ppm DIPE with [2-[14]C]DIPE Exposure on Last Day (Group 6)

                                    Sample
                                  Time point
                                     6-01
                                     6-02
                                     6-03
                                     6-04
                                     Mean
                                      SD
                             Adipose subcutaneous
                                     24 h
                                                                            180
                                                                            188
                                                                            124
                                                                           87.3
                                                                          145.0
                                                                           47.8
                               Adip (Abdominal)
                                     24 h
                                                                            620
                                                                            155
                                                                            347
                                                                            197
                                                                            330
                                                                            210
                             Muscle Gastrocnemius
                                     24 h
                                                                           12.4
                                                                           15.6
                                                                           12.3
                                                                            9.5
                                                                           12.5
                                                                            2.5
                                  Skin (neck)
                                     24 h
                                                                           37.8
                                                                           98.7
                                                                           41.6
                                                                           31.1
                                                                           52.3
                                                                           31.2
                                     Blood
                                     24 h
                                                                           21.8
                                                                           25.8
                                                                           26.6
                                                                           26.5
                                                                           25.2
                                                                            2.3
                                    Spleen
                                     24 h
                                                                           70.9
                                                                           84.9
                                                                           75.6
                                                                           56.9
                                                                           72.1
                                                                           11.7
                                     Liver
                                     24 h
                                                                            163
                                                                            222
                                                                            152
                                                                            101
                                                                            160
                                                                           49.7
                                    Kidney
                                     24 h
                                                                            109
                                                                            107
                                                                           85.1
                                                                           48.5
                                                                           87.4
                                                                           28.1
                                     Heart
                                     24 h
                                                                           54.4
                                                                           34.4
                                                                           40.3
                                                                           21.8
                                                                           37.7
                                                                           13.5
                                     Lung
                                     24 h
                                                                            108
                                                                            124
                                                                           79.2
                                                                           59.8
                                                                           92.8
                                                                           28.7
                                     Brain
                                     24 h
                                                                            9.6
                                                                           13.1
                                                                            9.7
                                                                            7.5
                                                                           10.0
                                                                            2.3
                                     Femur
                                     24 h
                                                                           33.8
                                                                           45.9
                                                                           31.9
                                                                           18.8
                                                                           32.6
                                                                           11.1
                              Ovaries and Uterus
                                     24 h
                                                                           82.6
                                                                           65.3
                                                                           56.2
                                                                           34.7
                                                                           59.7
                                                                           19.9
                                    Stomach
                                     24 h
                                                                           71.5
                                                                           22.9
                                                                           61.2
                                                                           38.6
                                                                           48.6
                                                                           21.9
                                Small Intestine
                                     24 h
                                                                            141
                                                                            161
                                                                            115
                                                                           77.4
                                                                            124
                                                                           36.1
                               Cecum+Lg Int+Rect
                                     24 h
                                                                            103
                                                                           87.7
                                                                           84.5
                                                                           46.9
                                                                           80.5
                                                                           23.8
                               Stomach Contents
                                     24 h
                                                                            3.6
                                                                            4.7
                                                                            6.3
                                                                            2.7
                                                                            4.3
                                                                            1.6
                             Small Intestine Cont
                                     24 h
                                                                           59.1
                                                                           74.3
                                                                           54.5
                                                                           39.4
                                                                           56.8
                                                                           14.4
                              Lg Int + Cecum Cont
                                     24 h
                                                                            323
                                                                           42.9
                                                                           39.1
                                                                            149
                                                                            139
                                                                            133
                                Carcass Digest
                                     24 h
                                                                           54.1
                                                                           52.9
                                                                           42.0
                                                                           28.1
                                                                           44.3
                                                                           12.1

Table 20.  Percent of Administered Dose Recovered in Excreta and Tissues 24 h Following Gavage Administration of [2-[14]C]DIPE (50 mg/kg) to Male F344 Rats (Group 7)
                                    Sample
                                  Time point
                                     7-01
                                     7-02
                                     7-03
                                     7-04
                                     Mean
                                      SD
Urine
                                     24 h
                                     2.63
                                     2.71
                                     2.21
                                     2.34
                                     2.47
                                     0.24

                                   Subtotal
                                     2.63
                                     2.71
                                     2.21
                                     2.34
                                     2.47
                                     0.24
Feces
                                     24 h
                                     0.24
                                     0.25
                                     0.18
                                     0.14
                                     0.20
                                     0.05

                                   Subtotal
                                     0.24
                                     0.25
                                     0.18
                                     0.14
                                     0.20
                                     0.05
CO2 Trap 1
                                      1 h
                                     0.33
                                     0.34
                                     0.21
                                     0.24
                                     0.28
                                     0.06
CO2 Trap 1
                                      3 h
                                     2.67
                                     2.98
                                     2.58
                                     2.56
                                     2.70
                                     0.19
CO2 Trap 1
                                      6 h
                                     8.38
                                     7.63
                                     6.46
                                     7.66
                                     7.53
                                     0.80
CO2 Trap 1
                                     24 h
                                     6.73
                                     5.43
                                     5.90
                                     7.05
                                     6.28
                                     0.74

                                   Subtotal
                                     18.1
                                     16.4
                                     15.2
                                     17.5
                                     16.8
                                     1.30
CO2 Trap 2
                                      1 h
                                     0.32
                                    **0.00
                                     *0.00
                                    **0.00
                                     0.08
                                     0.16
CO2 Trap 2
                                      3 h
                                     *0.01
                                     *0.01
                                    **0.00
                                    **0.00
                                     0.00
                                     0.00
CO2 Trap 2
                                      6 h
                                    **0.00
                                     *0.00
                                    **0.00
                                    **0.00
                                     0.00
                                     0.00
CO2 Trap 2
                                     24 h
                                     0.50
                                     0.86
                                     0.61
                                     0.63
                                     0.65
                                     0.15

                                   Subtotal
                                     0.83
                                     0.88
                                     0.61
                                     0.63
                                     0.74
                                     0.14
Exhaled VOC Trap 1
                                      1 h
                                     27.0
                                     19.3
                                     34.2
                                     29.4
                                     27.5
                                     6.20
Exhaled VOC Trap 1
                                      3 h
                                     17.0
                                     17.0
                                     16.0
                                     18.5
                                     17.1
                                     1.03
Exhaled VOC Trap 1
                                      6 h
                                     6.74
                                     8.77
                                     4.95
                                     5.83
                                     6.57
                                     1.64
Exhaled VOC Trap 1
                                     24 h
                                     1.13
                                     2.35
                                     N.C.
                                     1.30
                                     1.20
                                     0.96

                                   Subtotal
                                     51.8
                                     47.4
                                     55.1
                                     54.9
                                     52.3
                                     3.60
Exhaled VOC Trap 2
                                      1 h
                                     0.00
                                    **0.00
                                     *0.00
                                     *0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
                                      3 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Exhaled VOC Trap 2
                                      6 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Exhaled VOC Trap 2
                                     24 h
                                     0.00
                                     0.22
                                     0.08
                                     0.06
                                     0.09
                                     0.09

                                   Subtotal
                                     0.03
                                     0.23
                                     0.09
                                     0.08
                                     0.11
                                     0.09
Cage Rinse
                                     24 h
                                     0.17
                                     0.18
                                     0.20
                                     0.21
                                     0.19
                                     0.02
Adipose subcutaneous
                                     24 h
                                     0.01
                                     0.02
                                     0.01
                                     0.00
                                     0.01
                                     0.01
Adip (Abdominal)
                                     24 h
                                     0.00
                                     0.01
                                     0.01
                                     0.00
                                     0.01
                                     0.00
Muscle Gastrocnemius
                                     24 h
                                     0.01
                                     0.01
                                     0.00
                                     0.00
                                     0.00
                                     0.00
Skin (neck)
                                     24 h
                                     0.03
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.01
Blood
                                     24 h
                                     0.04
                                     0.04
                                     0.04
                                     0.04
                                     0.04
                                     0.00
Spleen
                                     24 h
                                     0.03
                                     0.03
                                     0.02
                                     0.02
                                     0.02
                                     0.00
Liver
                                     24 h
                                     0.74
                                     0.68
                                     0.51
                                     0.55
                                     0.62
                                     0.11
Kidney
                                     24 h
                                     0.10
                                     0.11
                                     0.08
                                     0.09
                                     0.09
                                     0.01
Heart
                                     24 h
                                     0.02
                                     0.02
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Lung
                                     24 h
                                     0.05
                                     0.06
                                     0.04
                                     0.04
                                     0.05
                                     0.01
Brain
                                     24 h
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.00
Femur
                                     24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Testes
                                     24 h
                                     0.04
                                     0.04
                                     0.03
                                     0.04
                                     0.04
                                     0.00
Stomach
                                     24 h
                                     0.05
                                     0.05
                                     0.03
                                     0.04
                                     0.04
                                     0.01
Small Intestine
                                     24 h
                                     0.28
                                     0.35
                                     0.21
                                     0.29
                                     0.28
                                     0.06
Cecum+Lg Int+Rect
                                     24 h
                                     0.13
                                     0.13
                                     0.15
                                     0.13
                                     0.13
                                     0.01
Stomach Contents
                                     24 h
                                     0.00
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Small Intestine Cont
                                     24 h
                                     0.14
                                     0.12
                                     0.14
                                     0.14
                                     0.14
                                     0.01
Lg Int + Cecum Cont
                                     24 h
                                     0.10
                                     0.12
                                     0.09
                                     0.10
                                     0.10
                                     0.02
Carcass Digest
                                     24 h
                                     4.53
                                     4.45
                                     3.66
                                     3.86
                                     4.12
                                     0.43

                                   Subtotal
                                     6.46
                                     6.46
                                     5.28
                                     5.63
                                     5.96
                                     0.60

                                     Total
                                     80.1
                                     74.3
                                     78.6
                                     81.3
                                     78.6
                                     3.05

Table 21.  Concentration of DIPE equivalents (ug/g) in Tissues 24 h Following Gavage Administration of  [2-[14]C]DIPE (50 mg/kg) to Male F344 Rats (Group 7)
Sample
Time point
                                     7-01
                                     7-02
                                     7-03
                                     7-04
                                     Mean
                                      SD
Adipose subcutaneous
24 h
                                     1.82
                                     4.13
                                     1.86
                                     1.50
                                     2.33
                                     1.21
Adip (Abdominal)
24 h
                                     2.99
                                     6.46
                                     2.08
                                     1.44
                                     3.24
                                     2.24
Muscle Gastrocnemius
24 h
                                     1.94
                                     1.40
                                     1.54
                                     1.42
                                     1.58
                                     0.25
Skin (neck)
24 h
                                     5.61
                                     6.68
                                     5.25
                                     5.99
                                     5.88
                                     0.61
Blood
24 h
                                     2.02
                                     1.84
                                     1.67
                                     1.81
                                     1.84
                                     0.14
Spleen
24 h
                                     5.01
                                     5.35
                                     4.39
                                     4.69
                                     4.86
                                     0.41
Liver
24 h
                                     7.93
                                     7.26
                                     5.84
                                     6.72
                                     6.94
                                     0.88
Kidney
24 h
                                     6.29
                                     6.28
                                     5.25
                                     6.08
                                     5.98
                                     0.49
Heart
24 h
                                     2.26
                                     2.18
                                     1.91
                                     2.07
                                     2.11
                                     0.15
Lung
24 h
                                     5.95
                                     5.83
                                     4.83
                                     4.89
                                     5.38
                                     0.60
Brain
24 h
                                     1.03
                                     0.98
                                     0.90
                                     1.10
                                     1.00
                                     0.08
Femur
24 h
                                     4.06
                                     3.13
                                     2.80
                                     2.87
                                     3.22
                                     0.58
Testes
24 h
                                     1.60
                                     1.64
                                     1.37
                                     1.49
                                     1.53
                                     0.12
Stomach
24 h
                                     4.45
                                     4.54
                                     3.13
                                     4.33
                                     4.11
                                     0.66
Small Intestine
24 h
                                     8.46
                                     9.39
                                     6.71
                                     8.63
                                     8.30
                                     1.13
Cecum+Lg Int+Rect
24 h
                                     5.04
                                     6.10
                                     4.22
                                     6.09
                                     5.36
                                     0.91
Stomach Contents
24 h
                                     0.26
                                     0.36
                                     0.39
                                     0.23
                                     0.31
                                     0.08
Small Intestine Cont
24 h
                                     4.09
                                     3.78
                                     3.63
                                     4.66
                                     4.04
                                     0.46
Lg Int + Cecum Cont
24 h
                                     1.95
                                     1.93
                                     1.68
                                     2.07
                                     1.91
                                     0.16
Carcass Digest
24 h
                                     2.71
                                     2.78
                                     2.18
                                     2.48
                                     2.54
                                     0.27

Table 22.  Percent of Administered Dose in Excreta and Tissues 24 h Following Gavage Administration of [2-[14]C]DIPE (50 mg/kg) to Female F344 Rats (Group 8)
Sample
                                  Time point
                                     8-01
                                     8-02
                                     8-03
                                     8-04
                                     Mean
                                      SD
Urine
                                     24 h
                                     1.92
                                     2.19
                                     2.44
                                     2.32
                                     2.22
                                     0.22

                                   Subtotal
                                     1.92
                                     2.19
                                     2.44
                                     2.32
                                     2.22
                                     0.22
Feces
                                     24 h
                                     0.14
                                     0.03
                                     0.14
                                     0.11
                                     0.11
                                     0.05

                                   Subtotal
                                     0.14
                                     0.03
                                     0.14
                                     0.11
                                     0.11
                                     0.05
CO2 Trap 1
                                      1 h
                                     0.30
                                     0.33
                                     0.16
                                     0.33
                                     0.28
                                     0.08
CO2 Trap 1
                                      3 h
                                     3.64
                                     3.12
                                     3.24
                                     3.13
                                     3.28
                                     0.24
CO2 Trap 1
                                      6 h
                                     9.26
                                     8.03
                                     9.74
                                     9.05
                                     9.02
                                     0.72
CO2 Trap 1
                                     24 h
                                     4.33
                                     5.58
                                     5.95
                                     6.08
                                     5.49
                                     0.80

                                   Subtotal
                                     17.5
                                     17.1
                                     19.1
                                     18.6
                                     18.1
                                     0.93
CO2 Trap 2
                                      1 h
                                     *0.01
                                     *0.01
                                     *0.00
                                    **0.00
                                     0.01
                                     0.00
CO2 Trap 2
                                      3 h
                                     *0.01
                                    **0.03
                                     *0.01
                                    **0.00
                                     0.01
                                     0.01
CO2 Trap 2
                                      6 h
                                    **0.01
                                     *0.01
                                    **0.00
                                    **0.00
                                     0.00
                                     0.00
CO2 Trap 2
                                     24 h
                                     *0.05
                                     0.25
                                     *0.01
                                     0.16
                                     0.12
                                     0.11

                                   Subtotal
                                     0.07
                                     0.30
                                     0.02
                                     0.16
                                     0.14
                                     0.12
Exhaled VOC Trap 1
                                      1 h
                                     35.0
                                     30.6
                                     15.3
                                     32.0
                                     28.2
                                     8.78
Exhaled VOC Trap 1
                                      3 h
                                     16.0
                                     19.4
                                     33.7
                                     15.0
                                     21.0
                                     8.66
Exhaled VOC Trap 1
                                      6 h
                                     4.84
                                     6.87
                                     5.92
                                     6.64
                                     6.07
                                     0.91
Exhaled VOC Trap 1
                                     24 h
                                     0.37
                                     0.75
                                     0.58
                                     0.65
                                     0.59
                                     0.16

                                   Subtotal
                                     56.2
                                     57.6
                                     55.6
                                     54.3
                                     55.9
                                     1.35
Exhaled VOC Trap 2
                                      1 h
                                    **0.00
                                    **0.00
                                     *0.00
                                    **0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
                                      3 h
                                     0.01
                                     0.01
                                     0.01
                                     0.00
                                     0.01
                                     0.00
Exhaled VOC Trap 2
                                      6 h
                                     0.01
                                     0.02
                                     0.01
                                     0.01
                                     0.01
                                     0.01
Exhaled VOC Trap 2
                                     24 h
                                    **0.00
                                     *0.00
                                    **0.00
                                     *0.00
                                     0.00
                                     0.00

                                   Subtotal
                                     0.02
                                     0.03
                                     0.03
                                     0.02
                                     0.02
                                     0.01
Cage Rinse
                                     24 h
                                     0.48
                                     0.28
                                     0.48
                                     0.23
                                     0.37
                                     0.13
Adipose subcutaneous
                                     24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.00
                                     0.01
                                     0.00
Adip (Abdominal)
                                     24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.00
                                     0.01
                                     0.00
Muscle Gastrocnemius
                                     24 h
                                     0.00
                                     0.00
                                     0.01
                                     0.00
                                     0.00
                                     0.00
Skin (neck)
                                     24 h
                                     0.03
                                     0.02
                                     0.03
                                     0.02
                                     0.02
                                     0.00
Blood
                                     24 h
                                     0.04
                                     0.05
                                     0.05
                                     0.05
                                     0.05
                                     0.00
Spleen
                                     24 h
                                     0.02
                                     0.03
                                     0.03
                                     0.03
                                     0.03
                                     0.00
Liver
                                     24 h
                                     0.55
                                     0.60
                                     0.62
                                     0.51
                                     0.57
                                     0.05
Kidney
                                     24 h
                                     0.07
                                     0.08
                                     0.09
                                     0.08
                                     0.08
                                     0.01
Heart
                                     24 h
                                     0.01
                                     0.02
                                     0.02
                                     0.01
                                     0.02
                                     0.00
Lung
                                     24 h
                                     0.05
                                     0.06
                                     0.07
                                     0.05
                                     0.06
                                     0.01
Brain
                                     24 h
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.00
Femur
                                     24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Ovaries and Uterus
                                     24 h
                                     0.03
                                     0.02
                                     0.04
                                     0.04
                                     0.03
                                     0.01
Stomach
                                     24 h
                                     0.04
                                     0.04
                                     0.05
                                     0.04
                                     0.04
                                     0.00
Small Intestine
                                     24 h
                                     0.23
                                     0.25
                                     0.26
                                     0.26
                                     0.25
                                     0.02
Cecum+Lg Int+Rect
                                     24 h
                                     0.17
                                     0.20
                                     0.19
                                     0.17
                                     0.18
                                     0.01
Stomach Contents
                                     24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Small Intestine Cont
                                     24 h
                                     0.17
                                     0.16
                                     0.22
                                     0.18
                                     0.18
                                     0.02
Lg Int + Cecum Cont
                                     24 h
                                     0.09
                                     0.08
                                     0.10
                                     0.09
                                     0.09
                                     0.01
Carcass Digest
                                     24 h
                                     3.02
                                     3.36
                                     3.68
                                     3.15
                                     3.30
                                     0.29

                                   Subtotal
                                     5.05
                                     5.30
                                     5.99
                                     4.96
                                     5.33
                                     0.47

                                     Total
                                     81.0
                                     82.5
                                     83.3
                                     80.5
                                     81.8
                                      1.3

Table 23.  Concentration of DIPE equivalents (ug/g) in Tissues 24 h Following Gavage Administration of [2-[14]C]DIPE (50 mg/kg) to Female F344 Rats (Group 8)
Sample
Time point
                                     8-01
                                     8-02
                                     8-03
                                     8-04
                                     MEAN
                                      SD
Adipose subcutaneous
                                      24h
                                     2.59
                                     2.32
                                     3.36
                                     1.34
                                     2.40
                                     0.83
Adip (Abdominal)
                                      24h
                                     1.92
                                     4.37
                                     4.03
                                     1.08
                                     2.85
                                     1.60
Muscle Gastrocnemius
                                      24h
                                     1.06
                                     0.99
                                     1.17
                                     0.96
                                     1.05
                                     0.09
Skin (neck)
                                      24h
                                     4.57
                                     6.17
                                     5.21
                                     5.32
                                     5.32
                                     0.66
Blood
                                      24h
                                     1.44
                                     1.76
                                     1.67
                                     1.68
                                     1.64
                                     0.14
Spleen
                                      24h
                                     4.21
                                     5.48
                                     5.49
                                     5.21
                                     5.10
                                     0.61
Liver
                                      24h
                                     7.16
                                     8.03
                                     7.89
                                     7.00
                                     7.52
                                     0.52
Kidney
                                      24h
                                     4.95
                                     5.60
                                     5.67
                                     5.22
                                     5.36
                                     0.34
Heart
                                      24h
                                     2.06
                                     2.38
                                     2.84
                                     2.05
                                     2.33
                                     0.37
Lung
                                      24h
                                     5.23
                                     5.57
                                     6.21
                                     5.47
                                     5.62
                                     0.42
Brain
                                      24h
                                     0.80
                                     0.78
                                     0.95
                                     0.95
                                     0.87
                                     0.09
Femur
                                      24h
                                     1.89
                                     2.94
                                     3.00
                                     2.25
                                     2.52
                                     0.54
Ovaries and Uterus
                                      24h
                                     3.65
                                     2.58
                                     5.34
                                     4.73
                                     4.08
                                     1.22
Stomach
                                      24h
                                     3.85
                                     4.13
                                     4.51
                                     4.06
                                     4.14
                                     0.28
Small Intestine
                                      24h
                                     8.30
                                     8.71
                                     9.01
                                     8.94
                                     8.74
                                     0.32
Cecum+Lg Int+Rect
                                      24h
                                     4.41
                                     4.90
                                     5.39
                                     5.36
                                     5.02
                                     0.46
Stomach Contents
                                      24h
                                     0.51
                                     0.30
                                     0.48
                                     1.01
                                     0.58
                                     0.30
Small Intestine Cont
                                      24h
                                     4.55
                                     5.29
                                     6.15
                                     5.68
                                     5.42
                                     0.68
Lg Int + Cecum Cont
                                      24h
                                     1.87
                                     1.84
                                     2.01
                                     2.45
                                     2.04
                                     0.28
Carcass Digest
                                      24h
                                     1.86
                                     2.16
                                     2.34
                                     1.94
                                     2.08
                                     0.22
Table 24.  Percent of Radioactivity Recovered in Excreta and Tissues 24 h Following Gavage Administration of [2-[14]C]DIPE (200 mg/kg) to Male F344 Rats (Group 9)
Sample
                                  Time point
                                     9-01
                                     9-02
                                     9-03
                                     9-04
Mean
                                      SD
Urine
                                     24 h
                                     1.60
                                     0.84
                                     1.69
                                     2.14
                                     1.57
                                     0.54

                                   Subtotal
                                     1.60
                                     0.84
                                     1.69
                                     2.14
                                     1.57
                                     0.54
Feces
                                     24 h
                                     0.13
                                     0.17
                                     0.22
                                     0.11
                                     0.16
                                     0.05

                                   Subtotal
                                     0.13
                                     0.17
                                     0.22
                                     0.11
                                     0.16
                                     0.05
CO2 Trap 1
                                      1 h
                                     0.10
                                     0.09
                                     0.09
                                     0.08
                                     0.09
                                     0.01
CO2 Trap 1
                                      3 h
                                     0.56
                                     0.51
                                     0.43
                                     0.45
                                     0.49
                                     0.06
CO2 Trap 1
                                      6 h
                                     2.32
                                     2.02
                                     1.65
                                     1.88
                                     1.97
                                     0.28
CO2 Trap 1
                                     24 h
                                     6.73
                                     5.86
                                     6.89
                                     6.35
                                     6.46
                                     0.46

                                   Subtotal
                                     9.71
                                     8.48
                                     9.06
                                     8.75
                                     9.00
                                     0.53
CO2 Trap 2
                                      1 h
                                    **0.00
                                     *0.00
                                     *0.00
                                    **0.00
                                     0.00
                                     0.00
CO2 Trap 2
                                      3 h
                                     *0.00
                                    **0.00
                                     *0.00
                                    **0.00
                                     0.00
                                     0.00
CO2 Trap 2
                                      6 h
                                    **0.00
                                     *0.00
                                     *0.00
                                     *0.00
                                     0.00
                                     0.00
CO2 Trap 2
                                     24 h
                                     0.31
                                     0.36
                                     0.78
                                     0.38
                                     0.46
                                     0.22

                                   Subtotal
                                     0.31
                                     0.36
                                     0.78
                                     0.38
                                     0.46
                                     0.22
Exhaled VOC Trap 1
                                      1 h
                                     25.5
                                     15.0
                                     26.4
                                     21.8
                                     22.2
                                     5.16
Exhaled VOC Trap 1
                                      3 h
                                     22.9
                                     21.1
                                     21.5
                                     26.3
                                     22.9
                                     2.37
Exhaled VOC Trap 1
                                      6 h
                                     7.86
                                     7.68
                                     10.9
                                     10.5
                                     9.25
                                     1.71
Exhaled VOC Trap 1
                                     24 h
                                     1.85
                                     1.55
                                     2.15
                                     2.57
                                     2.03
                                     0.43

                                   Subtotal
                                     58.1
                                     45.3
                                     61.0
                                     61.2
                                     56.4
                                     7.50
Exhaled VOC Trap 2
                                      1 h
                                     0.00
                                     0.00
                                     *0.00
                                    **0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
                                      3 h
                                     0.00
                                     N.C.
                                     N.C.
                                    **0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
                                      6 h
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
                                     24 h
                                     0.28
                                     0.66
                                     1.18
                                     0.14
                                     0.57
                                     0.47

                                   Subtotal
                                     0.29
                                     0.67
                                     1.19
                                     0.14
                                     0.57
                                     0.47
Cage Rinse
                                     24 h
                                     0.14
                                     0.79
                                     0.20
                                     0.13
                                     0.32
                                     0.32
Adipose subcutaneous
                                     24 h
                                     0.00
                                     0.00
                                     0.01
                                     0.00
                                     0.00
                                     0.00
Adip (Abdominal)
                                     24 h
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
Muscle Gastrocnemius
                                     24 h
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
Skin (neck)
                                     24 h
                                     0.01
                                     0.00
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Blood
                                     24 h
                                     0.03
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.00
Spleen
                                     24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Liver
                                     24 h
                                     0.33
                                     0.30
                                     0.36
                                     0.30
                                     0.32
                                     0.03
Kidney
                                     24 h
                                     0.05
                                     0.05
                                     0.05
                                     0.05
                                     0.05
                                     0.00
Heart
                                     24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Lung
                                     24 h
                                     0.03
                                     0.02
                                     0.03
                                     0.03
                                     0.03
                                     0.00
Brain
                                     24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Femur
                                     24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Testes
                                     24 h
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.00
Stomach
                                     24 h
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.00
Small Intestine
                                     24 h
                                     0.14
                                     0.10
                                     0.13
                                     0.13
                                     0.13
                                     0.02
Cecum+Lg Int+Rect
                                     24 h
                                     0.08
                                     0.08
                                     0.08
                                     0.08
                                     0.08
                                     0.00
Stomach Contents
                                     24 h
                                     0.00
                                     0.01
                                     0.01
                                     0.01
                                     0.00
                                     0.00
Small Intestine Cont
                                     24 h
                                     0.12
                                     0.12
                                     0.13
                                     0.07
                                     0.11
                                     0.02
Lg Int + Cecum Cont
                                     24 h
                                     0.05
                                     0.05
                                     0.05
                                     0.04
                                     0.05
                                     0.01
Carcass Digest
                                     24 h
                                     1.97
                                     1.98
                                     2.12
                                     2.07
                                     2.03
                                     0.07

                                   Subtotal
                                     3.04
                                     3.59
                                     3.28
                                     3.03
                                     3.24
                                     0.27

                                     Total
                                     73.2
                                     59.5
                                     77.2
                                     75.7
                                     71.4
                                     8.12

Table 25.  Concentration of DIPE equivalents (ug/g) in Tissues 24 h Following Gavage Administration of [2-[14]C]DIPE (200 mg/kg) to Male F344 Rats (Group 9)

Sample
                                  Time point
                                     9-01
                                     9-02
                                     9-03
                                     9-04
                                     Mean
                                      SD
Adipose subcutaneous
                                      24h
                                     2.59
                                     3.49
                                     4.67
                                     3.03
                                     3.45
                                     0.90
Adip (Abdominal)
                                      24h
                                     4.35
                                     5.03
                                     8.20
                                     5.94
                                     5.88
                                     1.68
Muscle Gastrocnemius
                                      24h
                                     3.25
                                     2.59
                                     2.71
                                     2.57
                                     2.78
                                     0.32
Skin (neck)
                                      24h
                                     11.0
                                     10.4
                                     10.5
                                     12.0
                                     11.0
                                     0.73
Blood
                                      24h
                                     3.87
                                     3.65
                                     3.95
                                     3.77
                                     3.81
                                     0.13
Spleen
                                      24h
                                     11.3
                                     10.1
                                     11.1
                                     9.79
                                     10.6
                                     0.74
Liver
                                      24h
                                     16.8
                                     14.4
                                     16.3
                                     13.9
                                     15.4
                                     1.42
Kidney
                                      24h
                                     14.4
                                     12.7
                                     13.9
                                     11.4
                                     13.1
                                     1.34
Heart
                                      24h
                                     5.21
                                     3.71
                                     4.67
                                     3.89
                                     4.37
                                     0.70
Lung
                                      24h
                                     12.4
                                     10.8
                                     12.9
                                     10.2
                                     11.6
                                     1.28
Brain
                                      24h
                                     2.34
                                     1.97
                                     1.99
                                     1.97
                                     2.07
                                     0.18
Femur
                                      24h
                                     7.38
                                     5.50
                                     6.44
                                     5.72
                                     6.26
                                     0.85
Testes
                                      24h
                                     3.44
                                     3.18
                                     3.19
                                     2.83
                                     3.16
                                     0.25
Stomach
                                      24h
                                     9.62
                                     8.11
                                     9.63
                                     8.55
                                     8.98
                                     0.77
Small Intestine
                                      24h
                                     21.2
                                     14.1
                                     19.4
                                     16.6
                                     17.8
                                     3.12
Cecum+Lg Int+Rect
                                      24h
                                     12.1
                                     11.5
                                     12.9
                                     10.9
                                     11.9
                                     0.85
Stomach Contents
                                      24h
                                     0.82
                                     2.48
                                     0.94
                                     1.42
                                     1.42
                                     0.76
Small Intestine Cont
                                      24h
                                     14.3
                                     17.6
                                     12.1
                                     8.71
                                     13.2
                                     3.74
Lg Int + Cecum Cont
                                      24h
                                     5.44
                                     5.25
                                     5.70
                                     3.77
                                     5.04
                                     0.87
Carcass Digest
                                      24h
                                     5.01
                                     4.93
                                     5.42
                                     5.22
                                     5.15
                                     0.22
Table 26.  Percent of Radioactivity Recovered in Excreta and Tissues 24 h Following Oral Gavage Administration of [2-[14]C]DIPE (200 mg/kg) to Female F344 Rats (Group 10)
Sample
                                  Time point
10-01
10-02
10-03
10-04
Mean
SD
Urine
                                     24 h
                                     1.54
                                     1.67
                                     1.49
                                     1.48
                                     1.55
                                     0.09

                                   Subtotal
                                     1.54
                                     1.67
                                     1.49
                                     1.48
                                     1.55
                                     0.09
Feces
                                     24 h
                                     0.07
                                     0.12
                                     0.06
                                     0.14
                                     0.10
                                     0.04

                                   Subtotal
                                     0.07
                                     0.12
                                     0.06
                                     0.14
                                     0.10
                                     0.04
CO2 Trap 1
                                      1 h
                                     0.10
                                     0.09
                                     0.11
                                     0.08
                                     0.09
                                     0.01
CO2 Trap 1
                                      3 h
                                     0.80
                                     0.71
                                     0.79
                                     0.59
                                     0.72
                                     0.10
CO2 Trap 1
                                      6 h
                                     3.24
                                     2.89
                                     2.86
                                     2.39
                                     2.85
                                     0.35
CO2 Trap 1
                                     24 h
                                     5.56
                                     6.70
                                     5.96
                                     2.39
                                     5.15
                                     1.90

                                   Subtotal
                                     9.71
                                     10.4
                                     9.72
                                     5.45
                                     8.81
                                     2.27
CO2 Trap 2
                                      1 h
                                    **0.00
                                    **0.00
                                    **0.00
                                    **0.00
                                     0.00
                                     0.00
CO2 Trap 2
                                      3 h
                                     *0.00
                                    **0.00
                                    **0.00
                                    **0.00
                                     0.00
                                     0.00
CO2 Trap 2
                                      6 h
                                    **0.00
                                     *0.00
                                     *0.00
                                     *0.00
                                     0.00
                                     0.00
CO2 Trap 2
                                     24 h
                                     *0.01
                                     *0.00
                                     *0.00
                                     0.07
                                     0.02
                                     0.04

                                   Subtotal
                                     0.01
                                     0.00
                                     0.00
                                     0.08
                                     0.02
                                     0.04
Exhaled VOC Trap 1
                                      1 h
                                     26.3
                                     24.9
                                     33.7
                                     25.0
                                     27.4
                                     4.20
Exhaled VOC Trap 1
                                      3 h
                                     23.9
                                     24.7
                                     19.5
                                     23.7
                                     23.0
                                     2.34
Exhaled VOC Trap 1
                                      6 h
                                     8.55
                                     9.59
                                     8.47
                                     10.4
                                     9.25
                                     0.92
Exhaled VOC Trap 1
                                     24 h
                                     1.14
                                     2.09
                                     1.93
                                     1.90
                                     1.76
                                     0.43

                                   Subtotal
                                     59.9
                                     61.30
                                     63.6
                                     61.0
                                     61.4
                                     1.55
Exhaled VOC Trap 2
                                      1 h
                                    **0.00
                                     *0.00
                                    **0.00
                                     *0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
                                      3 h
                                     0.00
                                     N.C.
                                    **0.00
                                     0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
                                      6 h
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
Exhaled VOC Trap 2
                                     24 h
                                     0.01
                                     0.02
                                     0.02
                                     0.04
                                     0.02
                                     0.01

                                   Subtotal
                                     0.02
                                     0.02
                                     0.03
                                     0.05
                                     0.03
                                     0.01
Cage Rinse
                                     24 h
                                     0.19
                                     0.16
                                     0.13
                                     0.21
                                     0.17
                                     0.03
Adipose subcutaneous
                                     24 h
                                     0.01
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
Adip (Abdominal)
                                     24 h
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
Muscle Gastrocnemius
                                     24 h
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
                                     0.00
Skin (neck)
                                     24 h
                                     0.02
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
Blood
                                     24 h
                                     0.03
                                     0.02
                                     0.03
                                     0.03
                                     0.03
                                     0.00
Spleen
                                     24 h
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.02
                                     0.00
Liver
                                     24 h
                                     0.35
                                     0.33
                                     0.38
                                     0.34
                                     0.35
                                     0.02
Kidney
                                     24 h
                                     0.05
                                     0.04
                                     0.04
                                     0.04
                                     0.05
                                     0.00
Heart
                                     24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Lung
                                     24 h
                                     0.04
                                     0.03
                                     0.03
                                     0.04
                                     0.04
                                     0.00
Brain
                                     24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Femur
                                     24 h
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.01
                                     0.00
Ovaries and Uterus
                                     24 h
                                     0.03
                                     0.04
                                     0.04
                                     0.01
                                     0.03
                                     0.01
Stomach
                                     24 h
                                     0.02
                                     0.01
                                     0.02
                                     0.02
                                     0.02
                                     0.01
Small Intestine
                                     24 h
                                     0.15
                                     0.15
                                     0.16
                                     0.13
                                     0.15
                                     0.01
Cecum+Lg Int+Rect
                                     24 h
                                     0.11
                                     0.11
                                     0.10
                                     0.10
                                     0.11
                                     0.00
Stomach Contents
                                     24 h
                                     0.00
                                     0.02
                                     0.01
                                     0.00
                                     0.01
                                     0.01
Small Intestine Cont
                                     24 h
                                     0.12
                                     0.13
                                     0.11
                                     0.14
                                     0.12
                                     0.01
Lg Int + Cecum Cont
                                     24 h
                                     0.05
                                     0.05
                                     0.05
                                     0.05
                                     0.05
                                     0.00
Carcass Digest
                                     24 h
                                     1.83
                                     1.88
                                     1.84
                                     1.71
                                     1.81
                                     0.07

                                   Subtotal
                                     3.04
                                     3.04
                                     3.00
                                     2.87
                                     2.99
                                     0.08

                                     Total
                                     74.3
                                     76.5
                                     77.9
                                     71.0
                                     74.9
                                     2.99

Table 27.  Concentration of DIPE equivalents (ug/g) in Tissues 24 h Following Oral Gavage Administration of [2-[14]C]DIPE (200 mg/kg) to Female F344 Rats (Group 10)

Sample
                                  Time point
                                     10-01
                                     10-02
                                     10-03
                                     10-04
                                     Mean
                                      SD
Adipose subcutaneous
                                      24h
                                     3.60
                                     5.58
                                     2.61
                                     4.02
                                     3.95
                                     1.24
Adip (Abdominal)
                                      24h
                                     4.45
                                     6.83
                                     2.73
                                     2.97
                                     4.25
                                     1.88
Muscle Gastrocnemius
                                      24h
                                     2.02
                                     1.92
                                     2.37
                                     1.88
                                     2.05
                                     0.22
Skin (neck)
                                      24h
                                     12.3
                                     9.00
                                     5.39
                                     12.4
                                     9.77
                                     3.32
Blood
                                      24h
                                     3.57
                                     3.57
                                     3.83
                                     3.74
                                     3.68
                                     0.13
Spleen
                                      24h
                                     11.6
                                     11.0
                                     11.6
                                     12.3
                                     11.6
                                     0.53
Liver
                                      24h
                                     19.8
                                     17.0
                                     19.2
                                     18.1
                                     18.5
                                     1.24
Kidney
                                      24h
                                     12.4
                                     11.8
                                     11.6
                                     11.8
                                     11.9
                                     0.35
Heart
                                      24h
                                     5.53
                                     5.09
                                     5.91
                                     4.59
                                     5.28
                                     0.57
Lung
                                      24h
                                     11.3
                                     13.0
                                     13.4
                                     13.1
                                     12.7
                                     0.95
Brain
                                      24h
                                     1.76
                                     1.72
                                     2.07
                                     1.76
                                     1.83
                                     0.16
Femur
                                      24h
                                     6.68
                                     5.69
                                     5.82
                                     5.79
                                     6.00
                                     0.46
Ovaries and Uterus
                                      24h
                                     11.20
                                     13.10
                                     7.62
                                     9.16
                                     10.30
                                     2.39
Stomach
                                      24h
                                     8.72
                                     1.76
                                     9.85
                                     10.70
                                     7.76
                                     4.08
Small Intestine
                                      24h
                                     19.8
                                     20.5
                                     20.9
                                     20.0
                                     20.3
                                     0.50
Cecum+Lg Int+Rect
                                      24h
                                     10.2
                                     12.8
                                     10.5
                                     11.1
                                     11.2
                                     1.16
Stomach Contents
                                      24h
                                     3.75
                                     10.00
                                     2.59
                                     0.50
                                     4.21
                                     4.09
Small Intestine Cont
                                      24h
                                     15.7
                                     13.9
                                     15.1
                                     13.9
                                     14.7
                                     0.90
Lg Int + Cecum Cont
                                      24h
                                     5.52
                                     5.16
                                     5.15
                                     5.33
                                     5.29
                                     0.17
Carcass Digest
                                      24h
                                     4.49
                                     4.69
                                     4.59
                                     4.27
                                     4.51
                                     0.18

Table 28.  Concentration of DIPE in blood from male and female rats exposed to 600 ppm DIPE.

                                   Male Rats
                                  Female Rats
                                   Time (hr)
                            DIPE[a] ug/mL in blood
                            DIPE[a] ug/mL in blood

                                     Mean
                                      SD
                                     Mean
                                      SD
                                    0.0833
                                     5.67
                                     0.21
                                     3.08
                                     1.22
                                    0.1667
                                     7.54
                                     0.35
                                     3.41
                                     2.75
                                     0.25
                                     8.86
                                     0.80
                                     6.67
                                     3.99
                                     0.50
                                     9.67
                                     0.24
                                     7.62
                                     5.11
                                       1
                                     11.7
                                     1.06
                                     8.77
                                     6.18
                                       2
                                     13.2
                                     1.25
                                     11.9
                                     3.90
                                       4
                                     12.8
                                     1.23
                                     13.1
                                     2.56
                                       6
                                     13.0
                                     1.17
                                     15.0
                                     1.99
                                     6.25
                                     3.72
                                     0.77
                                     5.31
                                     0.94
                                      6.5
                                     2.36
                                     0.34
                                     3.40
                                     0.79
                                       7
                                     1.12
                                     0.15
                                     1.87
                                     0.37
                                     7.33
                                     0.78
                                     0.17
                                     1.19
                                     0.32
                                       8
                                     0.46
                                     0.05
                                     0.68
                                     0.22
                                      10
                                     0.15
                                     0.12
                                     0.17
                                     0.06
                                      16
                                    <LOQ
                                    <LOQ
                                    <LOQ
                                    <LOQ
                                      24
                                    <LOQ
                                    <LOQ
                                    <LOQ
                                    <LOQ

[a] Values are mean +- SD  of 3 animals.
[b] Less than the limit of quantitation

Table 29.  Concentration of Isopropanol in blood from male and female rats exposed to 600 ppm DIPE.

                                   Male Rats
                                  Female Rats
Time (hr)
                             Isopropanol[a] ug/mL in blood
                            Isopropanol[a]  ug/mL in blood

                                     Mean
                                      SD
                                     Mean
                                      SD
                                    0.0833
                                     0.65
                                     0.29
                                     0.37
                                     0.16
                                    0.1667
                                     0.90
                                     0.10
                                     0.52
                                     0.10
                                     0.25
                                     1.28
                                     0.18
                                     0.69
                                     0.19
                                      0.5
                                     2.13
                                     0.38
                                     1.02
                                     0.42
                                       1
                                     3.61
                                     0.43
                                     1.55
                                     0.73
                                       2
                                     6.67
                                     0.97
                                     2.76
                                     1.55
                                       4
                                     13.3
                                     2.64
                                     5.75
                                     1.25
                                       6
                                     23.4
                                     4.05
                                     9.56
                                     2.10
                                     6.25
                                     18.6
                                     4.29
                                     9.23
                                     1.17
                                      6.5
                                     15.8
                                     3.96
                                     7.25
                                     0.54
                                       7
                                     11.0
                                     3.23
                                     4.84
                                     0.28
                                     7.33
                                     8.30
                                     2.03
                                     3.64
                                     0.15
                                       8
                                     5.09
                                     0.92
                                     2.22
                                     0.40
                                      10
                                     1.62
                                     0.31
                                     0.58
                                     0.16
                                      16
                                     0.08
                                     0.07
                                     0.37
                                     0.16
                                      24
                                    <LOQ
                                    <LOQ
                                    <LOQ
                                    <LOQ

[a] Values are mean +- SD  of 3 animals.
[b] Less than the limit of quantitation.
Table 30.  Concentration of Acetone in blood from male and female rats exposed to 600 ppm DIPE.

                                   Male Rats
                                  Female Rats
Time (hr)
                              Acetone[a] ug/mL in blood
                               Acetone[a] ug/mL in blood

                                     Mean
                                      SD
                                     Mean
                                      SD
                                    0.0833
                                     4.42
                                     1.34
                                     4.97
                                     2.02
                                    0.1667
                                     6.57
                                     0.90
                                     5.61
                                     1.83
                                     0.25
                                     8.46
                                     1.17
                                     6.53
                                     1.61
                                      0.5
                                     13.8
                                     1.54
                                     12.1
                                     1.95
                                       1
                                     27.1
                                     7.12
                                     20.5
                                     3.58
                                       2
                                     53.2
                                     9.24
                                     30.1
                                     14.2
                                       4
                                     102.0
                                     18.21
                                     65.1
                                     11.3
                                       6
                                     156.6
                                     13.43
                                     95.8
                                     5.76
                                     6.25
                                     147.2
                                     13.00
                                     100.5
                                     11.6
                                      6.5
                                     153.9
                                     11.67
                                     99.5
                                     6.94
                                       7
                                     157.8
                                     25.52
                                     96.7
                                     10.4
                                     7.33
                                     140.3
                                     9.34
                                     99.4
                                     15.6
                                       8
                                     128.2
                                     11.9
                                     79.6
                                     15.6
                                      10
                                     77.6
                                     12.4
                                     44.7
                                     7.47
                                      16
                                     2.38
                                     0.71
                                     2.64
                                     0.74
                                      24
                                     2.83
                                     0.70
                                     3.33
                                     0.26

[a] Values are mean +- SD  of 3 animals.

Table 31.  Concentration of DIPE in blood from male and female rats exposed to 3600 ppm DIPE.

                                   Male Rats
                                  Female Rats
                                   Time (hr)
                            DIPE[a] ug/mL in blood
                            DIPE[a] ug/mL in blood

                                     Mean
                                      SD
                                     Mean
                                      SD
                                    0.0833
                                     28.2
                                     2.72
                                     28.5
                                     19.54
                                    0.1667
                                     39.9
                                     0.81
                                     31.4
                                     20.00
                                     0.25
                                     35.5
                                     24.03
                                     50.6
                                     7.93
                                     0.50
                                     61.0
                                     2.34
                                     43.4
                                     29.5
                                       1
                                     66.1
                                     3.90
                                     54.5
                                     29.3
                                       2
                                     66.8
                                     7.97
                                     52.7
                                     28.2
                                       4
                                     65.2
                                     13.40
                                     63.3
                                     38.2
                                       6
                                     70.2
                                     3.39
                                     77.2
                                     33.9
                                     6.25
                                     22.6
                                     1.12
                                     29.5
                                     4.61
                                      6.5
                                     13.8
                                     3.78
                                     19.0
                                     2.66
                                       7
                                      7.2
                                     1.60
                                      9.7
                                     1.01
                                     7.33
                                      4.1
                                     0.46
                                      6.0
                                     1.31
                                       8
                                      3.1
                                     0.46
                                      3.9
                                     0.37
                                      10
                                      0.7
                                     0.22
                                      1.2
                                     0.36
                                      16
                                  <LOQ[b]
                                    <LOQ
                                    <LOQ
                                    <LOQ
                                      24
                                    <LOQ
                                    <LOQ
                                    <LOQ
                                    <LOQ

[a] Values are mean +- SD  of 3 animals.
[b] Less than the limit of quantitation
Table 32.  Concentration of Isopropanol in blood from male and female rats exposed to 3600 ppm DIPE.

                                   Male Rats
                                  Female Rats
Time (hr)
                             Isopropanol[a] ug/mL in blood
                            Isopropanol[a]  ug/mL in blood

                                     Mean
                                      SD
                                     Mean
                                      SD
                                    0.0833
                                     0.98
                                     0.35
                                     0.67
                                     0.40
                                    0.1667
                                     1.54
                                     0.22
                                     0.88
                                     0.30
                                     0.25
                                     1.15
                                     0.27
                                     2.10
                                     0.13
                                      0.5
                                     3.95
                                     0.41
                                     1.95
                                     0.95
                                       1
                                     7.92
                                     0.61
                                     3.53
                                     1.60
                                       2
                                     14.8
                                     1.89
                                     6.26
                                     2.49
                                       4
                                     30.2
                                     6.57
                                     12.3
                                     4.90
                                       6
                                     51.2
                                     5.02
                                     20.4
                                     5.10
                                     6.25
                                     55.5
                                     1.72
                                     24.5
                                     2.59
                                      6.5
                                     51.3
                                     3.61
                                     23.7
                                     1.88
                                       7
                                     43.2
                                     1.74
                                     19.3
                                     2.70
                                     7.33
                                     38.7
                                     1.93
                                     15.3
                                     1.85
                                       8
                                     27.2
                                     2.21
                                     10.3
                                     1.33
                                      10
                                     7.38
                                     0.53
                                     3.20
                                     0.97
                                      16
                                     0.36
                                     0.19
                                    <LOQ
                                    <LOQ
                                      24
                                    <LOQ
                                    <LOQ
                                    <LOQ
                                    <LOQ

[a] Values are mean +- SD  of 3 animals.
[b] Less than the limit of quantitation.

Table 33.  Concentration of Acetone in blood from male and female rats exposed to 3600 ppm DIPE.

                                   Male Rats
                                  Female Rats
                                   Time (hr)
                          Acetone[a] ug/mL in blood
                          Acetone[a] ug/mL in blood

                                     Mean
                                      SD
                                     Mean
                                      SD
                                    0.0833
                                     5.33
                                     1.73
                                     4.21
                                     1.31
                                    0.1667
                                     7.56
                                     0.36
                                     5.36
                                     0.45
                                     0.25
                                     7.23
                                     1.83
                                     8.75
                                     0.49
                                      0.5
                                     17.2
                                     3.28
                                     11.9
                                     0.75
                                       1
                                     34.1
                                     2.21
                                     23.1
                                     3.23
                                       2
                                     65.6
                                     6.02
                                     44.4
                                     6.75
                                       4
                                     137.4
                                     26.8
                                     87.3
                                     16.9
                                       6
                                     219.9
                                     5.03
                                     128.7
                                     15.2
                                     6.25
                                     236.4
                                     7.49
                                     142.1
                                     15.2
                                      6.5
                                     221.4
                                     39.9
                                     149.6
                                     4.68
                                       7
                                     222.1
                                     6.86
                                     154.1
                                     41.6
                                     7.33
                                     214.6
                                     5.03
                                     134.8
                                     9.17
                                       8
                                     230.1
                                     10.7
                                     132.5
                                     11.4
                                      10
                                     167.2
                                     11.9
                                     93.7
                                     12.6
                                      16
                                     23.5
                                     9.03
                                     10.3
                                     12.0
                                      24
                                     2.69
                                     0.31
                                     3.56
                                     1.06

[a] Values are mean +- SD  of 3 animals.
b Values are above the calibration curve and are extraolated

Table 34.	  Pharmacokinetic Analysis of DIPE, Isopropanol and Acetone in male and female rats exposed to 600 ppm DIPE.

                                     Units
                                     DIPE
                                     DIPE
                                  Isopropanol
                                  Isopropanol
                                    Acetone
                                    Acetone

                                     Male
                                    Female
                                     Male
                                    Female
                                     Male
                                    Female
                                     Cmax
                                    ug /mL
                                    13.2301
                                    14.9502
                                    23.3910
                                     9.5595
                                     157.8
                                    100.50
                                     Tmax
                                      hr
                                      2.0
                                      6.0
                                      6.0
                                      6.0
                                      7.0
                                     6.25
                                   Half Life
                                      hr
                                     1.1453
                                     0.9498
                                     1.3518
                                     1.0145
                                    2.5469
                                    2.9940
                                   Lambda z
                                     1/hr
                                     0.7298
                                     0.6052
                                     0.5128
                                     0.6833
                                    0.2722
                                    0.2315
                                    AUCall
                                  ug·hr/mL
                                    78.4022
                                    77.2737
                                    99.6158
                                    40.5142
                                   1227.489
                                    774.142

Table 35.	  Pharmacokinetic Analysis of DIPE, Isopropanol and Acetone in male and female rats exposed to 3600 ppm DIPE.

                                     Units
                                     DIPE
                                     DIPE
                                  Isopropanol
                                  Isopropanol
                                    Acetone
                                    Acetone

                                     Male
                                    Female
                                     Male
                                    Female
                                     Male
                                    Female
                                     Cmax
                                    ug /mL
                                    70.1978
                                    77.2485
                                    66.1823
                                    35.7084
                                   236.3895
                                   154.1144
                                     Tmax
                                      hr
                                       6
                                       6
                                       6
                                     6.25
                                     6.25
                                      7.0
                                   Half Life
                                      hr
                                    1.0252
                                    1.1255
                                    1.1598
                                    1.2261
                                    2.4278
                                    2.9428
                                   Lambda z
                                     1/hr
                                    0.6761
                                    0.6158
                                    0.5653
                                    0.5976
                                    0.2.855
                                    0.2355
                                    AUCall
                                  ug·hr/mL
                                   414.3046
                                   391.1130
                                    338.858
                                   156.0429
                                   2148.006
                                   1271.339

Table 36.	  Recovery of DIPE in Excreta and Tissues Following Inhalation Exposure of Male and Female F344 Rats to 600 ppm or 3600 ppm

                                   600 ppm
                                   Group 1
                                   Male Rats
                                   600 ppm
                              Group 2 Female Rats
                               3600 ppm Group 3
                                   Male Rats
                               3600 ppm Group 4
                                  Female Rats
Sample
Time point
                                     Mean
                                      SD
                                     Mean
                                      SD
                                     Mean
                                      SD
                                     Mean
                                      SD
Urine
Subtotal
                                     5.09
                                      1.2
                                     4.25
                                     1.67
                                     4.21
                                     0.76
                                     3.55
                                     0.26
Feces
Subtotal
                                     0.94
                                     0.71
                                     0.48
                                     0.17
                                     0.44
                                     0.08
                                     0.28
                                     0.12
CO2 Trap 1
SUBTOTAL
                                     38.42
                                     1.55
                                    41.21a
                                     1.38