Reported Chronic endpoint 30 2 Dose or Diet Rat Calculated Endpoint 1.5 mg/ kg bw based on standard FDA lab rat conversion Would you like to calculate an LD50 ft 2 for this use? 2 0%

TREX MODEL INPUTS Page 2 Napropamide C 11 Upper Bound Kenaga Residues For RQ Calculation Acute and Chronic RQs are based on the Upper Bound Kenaga Residues. Chemical Name: Napropamid e The maximum single day residue estimation is used for Use 0 both the acute and reproduction RQs. Formulation 0 Application Rate 0.443 lbs a. i./ acre Half life 35 days Application Interval 60 days Maximum # Apps./ Year 2 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration of Concern Avian acute LC50 Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Note: To provide risk management with the maximum possible information, Bobwhite quail LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentration based Bobwhite quail NOAEL ( mg/ kg bw) 0 RQs be calculated when data are available Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 Note: To provide risk management with the maximum possible information, LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentration based NOAEL ( mg/ kg bw) 1.5 RQs be calculated when data are available NOAEC ( mg/ kg diet) 30 EECs ( ppm) Kenaga Values Short Grass 138.72 Tall Grass 63.58 Broadleaf plants/ sm 78.03 C 12 Insects Fruits/ pods/ seeds/ lg insects 8.67 Avian Results Avian Body % body wgt Adjusted Class Weight consumed LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g Short Grass 158 90 40 Tall Grass 72 41 18 Broadleaf plants/ sm Insects 89 51 23 Fruits/ pods/ lg insects 10 6 3 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.07 0.03 0.01 Tall Grass 0.03 0.01 0.00 Broadleaf plants/ sm insects 0.04 0.02 0.01 Fruits/ pods/ lg insects 0.00 0.00 0.00 Dietary based RQs ( EEC/ LC50 or NOAEC) RQs Acute Chronic Short Grass # DIV/ 0! 0.05 Tall Grass # DIV/ 0! 0.02 Broadleaf plants/ sm Insects # DIV/ 0! 0.03 Fruits/ pods/ lg insects # DIV/ 0! 0.00 C 13 Napropamide 0 Upper bound Kenaga Residues Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consumed LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 EEC equivalent dose ( mg/ kg bw) Mammalian Classes and Body weight Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 132 92 21 Tall Grass 60 42 10 C 14 Broadleaf plants/ sm Insects 74 52 12 Fruits/ pods/ seeds/ lg insects 8 6 1 2 1 0 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.01 39.97 0.01 34.32 0.01 18.04 Tall Grass 0.01 18.32 0.00 15.73 0.00 8.27 Broadleaf plants/ sm insects 0.01 22.49 0.01 19.31 0.00 10.14 Fruits/ pods/ lg insects 0.00 2.50 0.00 2.15 0.00 1.13 Seeds ( granivore) 0.00 0.55 0.00 0.49 0.00 0.23 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 4.62 Tall Grass # DIV/ 0! 2.12 Broadleaf plants/ sm insects # DIV/ 0! 2.60 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 0.29 Mean Kenaga Residues For Risk Description Purposes Chemical Name: Naprop amide Use 0 Formulation 0 Application Rate 0.443 lbs a. i./ acre Half life 35 days Application Interval 60 days C 15 Maximum # Apps./ Year 2 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration of Concern Avian acute LC50 Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Bobwhite quail LC50 ( mg/ kg diet) 0 Bobwhite quail NOAEL ( mg/ kg bw) 0 Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet) 0 NOAEL ( mg/ kg bw) 1.5 NOAEC ( mg/ kg diet) 30 EECs ( ppm) Kenaga Values Short Grass 49.13 Tall Grass 20.81 Broadleaf plants/ sm Insects 26.01 Fruits/ pods/ seeds/ lg insects 4.05 Avian Results Avian Body % body wgt Adjusted Class Weight consume d LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g C 16 Short Grass 56 32 14 Tall Grass 24 14 6 Broadleaf plants/ sm Insects 30 17 8 Fruits/ pods/ lg insects 5 3 1 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.02 0.01 0.00 Tall Grass 0.01 0.00 0.00 Broadleaf plants/ sm insects 0.01 0.01 0.00 Fruits/ pods/ lg insects 0.00 0.00 0.00 Dietary based RQs ( EEC/ LC50 or NOAEC) RQs Acute Chronic Short Grass # DIV/ 0! 0.02 Tall Grass # DIV/ 0! 0.01 Broadleaf plants/ sm Insects # DIV/ 0! 0.01 Fruits/ pods/ lg insects # DIV/ 0! 0.00 C 17 Napropamide 0 Mean Kenaga Residues Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 EEC equivalent dose ( mg/ kg bw) Mammalian Classes and Body weight Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 47 32 7 Tall Grass 20 14 3 Broadleaf plants/ sm Insects 25 17 4 Fruits/ pods/ seeds/ lg insects 4 3 1 1 1 0 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.00 14.16 0.00 12.16 0.00 6.39 Tall Grass 0.00 6.00 0.00 5.15 0.00 2.71 Broadleaf plants/ sm insects 0.00 7.50 0.00 6.44 0.00 3.38 Fruits/ pods/ lg insects 0.00 1.17 0.00 1.00 0.00 0.53 C 18 Seeds ( granivore) 0.00 0.26 0.00 0.23 0.00 0.11 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 1.64 Tall Grass # DIV/ 0! 0.69 Broadleaf plants/ sm insects # DIV/ 0! 0.87 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 0.13 2 lbs ai/ a broadcast once TREX MODEL INPUTS These values will be used in the calculation of exposure estimates for foliar, granular, liquid and/ or seed applications of pesticides.

Chemical Name: Napropamide Use: Product name and form:

% A. I.: Application Rate: 2 Half life: 35 Application Interval:

Maximum # Apps./ Year: 1 Length of Simulation: 1 year Concentration of Concern: 2250 ( ppm)

Choose label: 1 Endpoints Avian Indicate test species below LD50 ( mg/ kg bw) 4640 2 C 19 LC50 ( mg/ kg diet) 1 NOAEL ( mg/ kg bw) 1 NOAEC ( mg/ kg diet) 3000 1 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet)

Reported Chronic endpoint 30 2 Dose or Diet Rat Calculated Endpoint 1.5 mg/ kg bw based on standard Would you like to calculate an LD50 ft 2 for this use? 2 0%

TREX MODEL INPUTS Page 2 Napropamide Upper Bound Kenaga Residues For RQ Calculation Acute and Chronic RQs are based on the Upper Bound Kenaga Residues.

Chemical Name: Naprop amide The maximum single day residue estimation is used for Use 0 both the acute and reproduction RQs. Formulation 0 Application Rate 2 lbs a. i./ acre Half life 35 days Application Interval 0 days Maximum # Apps./ Year 1 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration Avian acute LC50 C 20 of Concern Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Note: To provide risk management with the maximum possible information, Bobwhite quail LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentrationbased Bobwhite quail NOAEL ( mg/ kg bw) 0 RQs be calculated when data are available Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 Note: To provide risk management with the maximum possible information, LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentrationbased NOAEL ( mg/ kg bw) 1.5 RQs be calculated when data are available NOAEC ( mg/ kg diet) 30 EECs ( ppm) Kenaga Values Short Grass 480.00 Tall Grass 220.00 Broadleaf plants/ sm Insects 270.00 Fruits/ pods/ seeds/ lg insects 30.00 Avian Results Avian Body % body wgt Adjusted Class Weight consume d LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large C 21 20 g 100 g 1000 g Short Grass 547 312 139 Tall Grass 251 143 64 Broadleaf plants/ sm Insects 308 176 78 Fruits/ pods/ lg insects 34 20 9 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.24 0.11 0.03 Tall Grass 0.11 0.05 0.02 Broadleaf plants/ sm insects 0.13 0.06 0.02 Fruits/ pods/ lg insects 0.01 0.01 0.00 Dietary based RQs ( EEC/ LC50 or NOAEC) RQs Acute Chronic Short Grass # DIV/ 0! 0.16 Tall Grass # DIV/ 0! 0.07 Broadleaf plants/ sm Insects # DIV/ 0! 0.09 Fruits/ pods/ lg insects # DIV/ 0! 0.01 C 22 Napropamide 0 Upper bound Kenaga Residues Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 EEC equivalent dose ( mg/ kg bw) Mammalian Classes and Body weight Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 456 317 72 Tall Grass 209 145 33 Broadleaf plants/ sm Insects 257 178 41 Fruits/ pods/ seeds/ lg insects 29 20 5 6 5 1 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.04 138.32 0.04 118.77 0.02 62.41 Tall Grass 0.02 63.40 0.02 54.43 0.01 28.60 Broadleaf plants/ sm insects 0.02 77.80 0.02 66.81 0.01 35.10 C 23 Fruits/ pods/ lg insects 0.00 8.64 0.00 7.42 0.00 3.90 Seeds ( granivore) 0.00 1.91 0.00 1.69 0.00 0.78 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 16.00 Tall Grass # DIV/ 0! 7.33 Broadleaf plants/ sm insects # DIV/ 0! 9.00 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 1.00 Mean Kenaga Residues For Risk Description Purposes Chemical Name: Naprop amide Use 0 Formulation 0 Application Rate 2 lbs a. i./ acre Half life 35 days Application Interval 0 days Maximum # Apps./ Year 1 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration of Concern Avian acute LC50 Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Bobwhite quail LC50 ( mg/ kg diet) 0 Bobwhite quail NOAEL ( mg/ kg bw) 0 Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet) 0 C 24 NOAEL ( mg/ kg bw) 1.5 NOAEC ( mg/ kg diet) 30 EECs ( ppm) Kenaga Values Short Grass 170.00 Tall Grass 72.00 Broadleaf plants/ sm Insects 90.00 Fruits/ pods/ seeds/ lg insects 14.00 Avian Results Avian Body % body wgt Adjusted Class Weight consume d LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g Short Grass 194 111 49 Tall Grass 82 47 21 Broadleaf plants/ sm Insects 103 59 26 Fruits/ pods/ lg insects 16 9 4 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.08 0.04 0.01 Tall Grass 0.04 0.02 0.00 Broadleaf plants/ sm insects 0.04 0.02 0.01 Fruits/ pods/ lg insects 0.01 0.00 0.00 C 25 Dietary based RQs ( EEC/ LC50 or NOAEC) RQs Acute Chronic Short Grass # DIV/ 0! 0.06 Tall Grass # DIV/ 0! 0.02 Broadleaf plants/ sm Insects # DIV/ 0! 0.03 Fruits/ pods/ lg insects # DIV/ 0! 0.00 Napropamide 0 Mean Kenaga Residues Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 C 26 EEC equivalent dose ( mg/ kg bw) Mammalian Classes and Body weight Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 162 112 26 Tall Grass 68 48 11 Broadleaf plants/ sm Insects 86 59 14 Fruits/ pods/ seeds/ lg insects 13 9 2 3 2 0 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.01 48.99 0.01 42.06 0.01 22.10 Tall Grass 0.01 20.75 0.01 17.81 0.00 9.36 Broadleaf plants/ sm insects 0.01 25.93 0.01 22.27 0.00 11.70 Fruits/ pods/ lg insects 0.00 4.03 0.00 3.46 0.00 1.82 Seeds ( granivore) 0.00 0.89 0.00 0.79 0.00 0.36 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 5.67 Tall Grass # DIV/ 0! 2.40 Broadleaf plants/ sm insects # DIV/ 0! 3.00 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 0.47 C 27 3 lbs ai/ a x 2 apps TREX MODEL INPUTS These values will be used in the calculation of exposure estimates for foliar, granular, liquid and/ or seed applications of pesticides.

Chemical Name: Napropamide Use: Product name and form:

% A. I.: Application Rate: 3 Half life: 35 Application Interval: 60 Maximum # Apps./ Year: 2 Length of Simulation: 1 year Concentration of Concern: 2250 ( ppm)

Choose label: 1 Endpoints Avian Indicate test species below LD50 ( mg/ kg bw) 4640 2 LC50 ( mg/ kg diet) 1 NOAEL ( mg/ kg bw) 1 NOAEC ( mg/ kg diet) 3000 1 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet)

Reported Chronic endpoint 30 2 Dose or Diet Rat Calculated Endpoint 1.5 mg/ kg bw based on standard rat conversion Would you like to calculate an 2 C 28 LD50 ft 2 for this use?

0%

TREX MODEL INPUTS Page 2 Napropamide Upper Bound Kenaga Residues For RQ Calculation Acute and Chronic RQs are based on the Upper Bound Kenaga Residues.

Chemical Name: Naprop amide The maximum single day residue estimation is used for Use 0 both the acute and reproduction RQs. Formulation 0 Application Rate 3 lbs a. i./ acre Half life 35 days Application Interval 60 days Maximum # Apps./ Year 2 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration of Concern Avian acute LC50 Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Note: To provide risk management with the maximum possible information, Bobwhite quail LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentrationbased Bobwhite quail NOAEL ( mg/ kg bw) 0 RQs be calculated when data are available Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 Note: To provide risk management with the maximum possible information, LC50 ( mg/ kg diet) 0 it is recommended that both the C 29 dose based and concentrationbased NOAEL ( mg/ kg bw) 1.5 RQs be calculated when data are available NOAEC ( mg/ kg diet) 30 EECs ( ppm) Kenaga Values Short Grass 939.42 Tall Grass 430.57 Broadleaf plants/ sm Insects 528.43 Fruits/ pods/ seeds/ lg insects 58.71 Avian Results Avian Body % body wgt Adjusted Class Weight consume d LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g Short Grass 1071 611 272 Tall Grass 491 280 125 Broadleaf plants/ sm Insects 602 343 153 Fruits/ pods/ lg insects 67 38 17 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.46 0.21 0.07 Tall Grass 0.21 0.09 0.03 Broadleaf plants/ sm insects 0.26 0.12 0.04 C 30 Fruits/ pods/ lg insects 0.03 0.01 0.00 Dietary based RQs ( EEC/ LC50 or NOAEC) RQs Acute Chronic Short Grass # DIV/ 0! 0.31 Tall Grass # DIV/ 0! 0.14 Broadleaf plants/ sm Insects # DIV/ 0! 0.18 Fruits/ pods/ lg insects # DIV/ 0! 0.02 Napropamide 0 Upper bound Kenaga Residues Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 C 31 1000 3 3846 1 EEC equivalent dose ( mg/ kg bw) Mammalian Classes and Body weight Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 892 620 141 Tall Grass 409 284 65 Broadleaf plants/ sm Insects 502 349 79 Fruits/ pods/ seeds/ lg insects 56 39 9 12 9 2 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.08 270.71 0.07 232.44 0.04 122.14 Tall Grass 0.04 124.07 0.03 106.54 0.02 55.98 Broadleaf plants/ sm insects 0.05 152.27 0.04 130.75 0.02 68.70 Fruits/ pods/ lg insects 0.01 16.92 0.00 14.53 0.00 7.63 Seeds ( granivore) 0.00 3.74 0.00 3.30 0.00 1.53 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 31.31 Tall Grass # DIV/ 0! 14.35 Broadleaf plants/ sm insects # DIV/ 0! 17.61 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 1.96 C 32 Mean Kenaga Residues For Risk Description Purposes Chemical Name: Naprop amide Use 0 Formulation 0 Application Rate 3 lbs a. i./ acre Half life 35 days Application Interval 60 days Maximum # Apps./ Year 2 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration of Concern Avian acute LC50 Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Bobwhite quail LC50 ( mg/ kg diet) 0 Bobwhite quail NOAEL ( mg/ kg bw) 0 Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet) 0 NOAEL ( mg/ kg bw) 1.5 NOAEC ( mg/ kg diet) 30 EECs ( ppm) Kenaga Values Short Grass 332.71 Tall Grass 140.91 Broadleaf plants/ sm Insects 176.14 Fruits/ pods/ seeds/ lg insects 27.40 Avian Results Avian Body % body Adjusted C 33 wgt Class Weight consume d LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g Short Grass 379 216 96 Tall Grass 161 92 41 Broadleaf plants/ sm Insects 201 114 51 Fruits/ pods/ lg insects 31 18 8 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.16 0.07 0.02 Tall Grass 0.07 0.03 0.01 Broadleaf plants/ sm insects 0.09 0.04 0.01 Fruits/ pods/ lg insects 0.01 0.01 0.00 Dietary based RQs ( EEC/ LC50 or NOAEC) RQs Acute Chronic Short Grass # DIV/ 0! 0.11 Tall Grass # DIV/ 0! 0.05 Broadleaf plants/ sm Insects # DIV/ 0! 0.06 Fruits/ pods/ lg insects # DIV/ 0! 0.01 C 34 Napropamide 0 Mean Kenaga Residues Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 EEC equivalent dose ( mg/ kg bw) Mammalian Classes and Body weight Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 316 220 50 Tall Grass 134 93 21 Broadleaf plants/ sm Insects 167 116 26 Fruits/ pods/ seeds/ lg insects 26 18 4 6 4 1 C 35 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.03 95.88 0.02 82.32 0.01 43.26 Tall Grass 0.01 40.61 0.01 34.87 0.01 18.32 Broadleaf plants/ sm insects 0.02 50.76 0.01 43.58 0.01 22.90 Fruits/ pods/ lg insects 0.00 7.90 0.00 6.78 0.00 3.56 Seeds ( granivore) 0.00 1.75 0.00 1.54 0.00 0.71 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 11.09 Tall Grass # DIV/ 0! 4.70 Broadleaf plants/ sm insects # DIV/ 0! 5.87 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 0.91 4 lbs ai/ A * 1 app TREX MODEL INPUTS These values will be used in the calculation of exposure estimates for foliar, granular, liquid and/ or seed applications of pesticides.

Chemical Name: Napropamide Use:

Product name and form: % A. I.:

Application Rate: 4 C 36 Half life: 35 Application Interval:

Maximum # Apps./ Year: 1 Length of Simulation: 1 year Concentration of Concern: 2250 ( ppm)

Choose label: 1 Endpoints Avian Indicate test species below LD50 ( mg/ kg bw) 4640 2 LC50 ( mg/ kg diet) 1 NOAEL ( mg/ kg bw) 1 NOAEC ( mg/ kg diet) 3000 1 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet)

Reported Chronic endpoint 30 2 Dose or Diet Rat Calculated Endpoint 1.5 mg/ kg bw based on standard rat conversion Would you like to calculate an LD50 ft 2 for this use? 2 0%

TREX MODEL INPUTS Page 2 Napropamide Upper Bound Kenaga Residues For RQ Calculation Acute and Chronic RQs are based on the Upper Bound C 37 Kenaga Residues.

Chemical Name: Naprop amide The maximum single day residue estimation is used for Use 0 both the acute and reproduction RQs. Formulation 0 Application Rate 4 lbs a. i./ acre Half life 35 days Application Interval 0 days Maximum # Apps./ Year 1 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration of Concern Avian acute LC50 Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Note: To provide risk management with the maximum possible information, Bobwhite quail LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentrationbased Bobwhite quail NOAEL ( mg/ kg bw) 0 RQs be calculated when data are available Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 Note: To provide risk management with the maximum possible information, LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentrationbased NOAEL ( mg/ kg bw) 1.5 RQs be calculated when data are available NOAEC ( mg/ kg diet) 30 EECs ( ppm) Kenaga Values Short Grass 960.00 Tall Grass 440.00 Broadleaf plants/ sm Insects 540.00 Fruits/ pods/ seeds/ lg insects 60.00 Avian Results C 38 Avian Body % body wgt Adjusted Class Weight consume d LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g Short Grass 1094 624 278 Tall Grass 502 286 128 Broadleaf plants/ sm Insects 616 351 157 Fruits/ pods/ lg insects 68 39 17 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.47 0.21 0.07 Tall Grass 0.22 0.10 0.03 Broadleaf plants/ sm insects 0.26 0.12 0.04 Fruits/ pods/ lg insects 0.03 0.01 0.00 Dietary based RQs ( EEC/ LC50 or NOAEC) RQs Acute Chronic Short Grass # DIV/ 0! 0.32 Tall Grass # DIV/ 0! 0.15 Broadleaf plants/ sm Insects # DIV/ 0! 0.18 Fruits/ pods/ lg insects # DIV/ 0! 0.02 C 39 Napropamide 0 Upper bound Kenaga Residues Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 EEC equivalent dose ( mg/ kg bw) Mammalian Classes and Body weight Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 912 634 144 Tall Grass 418 290 66 Broadleaf plants/ sm Insects 513 356 81 Fruits/ pods/ seeds/ lg insects 57 40 9 13 9 2 C 40 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.08 276.64 0.07 237.53 0.04 124.81 Tall Grass 0.04 126.79 0.03 108.87 0.02 57.21 Broadleaf plants/ sm insects 0.05 155.61 0.04 133.61 0.02 70.21 Fruits/ pods/ lg insects 0.01 17.29 0.00 14.85 0.00 7.80 Seeds ( granivore) 0.00 3.82 0.00 3.37 0.00 1.56 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 32.00 Tall Grass # DIV/ 0! 14.67 Broadleaf plants/ sm insects # DIV/ 0! 18.00 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 2.00 Mean Kenaga Residues For Risk Description Purposes Chemical Name: Naprop amide Use 0 Formulation 0 Application Rate 4 lbs a. i./ acre Half life 35 days Application Interval 0 days Maximum # Apps./ Year 1 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration Avian acute LC50 C 41 of Concern Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Bobwhite quail LC50 ( mg/ kg diet) 0 Bobwhite quail NOAEL ( mg/ kg bw) 0 Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet) 0 NOAEL ( mg/ kg bw) 1.5 NOAEC ( mg/ kg diet) 30 EECs ( ppm) Kenaga Values Short Grass 340.00 Tall Grass 144.00 Broadleaf plants/ sm Insects 180.00 Fruits/ pods/ seeds/ lg insects 28.00 Avian Results Avian Body % body wgt Adjusted Class Weight consume d LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g Short Grass 388 221 99 Tall Grass 164 94 42 Broadleaf plants/ sm Insects 205 117 52 C 42 Fruits/ pods/ lg insects 32 18 8 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.17 0.07 0.02 Tall Grass 0.07 0.03 0.01 Broadleaf plants/ sm insects 0.09 0.04 0.01 Fruits/ pods/ lg insects 0.01 0.01 0.00 Dietary based RQs ( EEC/ LC50 or NOAEC) RQs Acute Chronic Short Grass # DIV/ 0! 0.11 Tall Grass # DIV/ 0! 0.05 Broadleaf plants/ sm Insects # DIV/ 0! 0.06 Fruits/ pods/ lg insects # DIV/ 0! 0.01 Napropamide 0 Mean Kenaga Residues C 43 Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 EEC equivalent dose ( mg/ kg bw) Mammalian Classes and Body weight Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 323 224 51 Tall Grass 137 95 22 Broadleaf plants/ sm Insects 171 119 27 Fruits/ pods/ seeds/ lg insects 27 18 4 6 4 1 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.03 97.98 0.03 84.13 0.01 44.20 Tall Grass 0.01 41.50 0.01 35.63 0.01 18.72 Broadleaf plants/ sm insects 0.02 51.87 0.01 44.54 0.01 23.40 Fruits/ pods/ lg insects 0.00 8.07 0.00 6.93 0.00 3.64 Seeds ( granivore) 0.00 1.78 0.00 1.57 0.00 0.73 C 44 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 11.33 Tall Grass # DIV/ 0! 4.80 Broadleaf plants/ sm insects # DIV/ 0! 6.00 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 0.93 4 lbs ai/ A broadcast at 60 days apart TREX MODEL INPUTS These values will be used in the calculation of exposure estimates for foliar, granular, liquid and/ or seed applications of pesticides.

Chemical Name: Napropamide Use: Product name and form:

% A. I.: Application Rate: 4 Half life: 35 Application Interval: 60 Maximum # Apps./ Year: 2 Length of Simulation: 1 year Concentration of Concern: 2250 ( ppm)

Choose label: 1 Endpoints Avian Indicate test species below LD50 ( mg/ kg bw) 4640 2 LC50 ( mg/ kg diet) 1 NOAEL ( mg/ kg bw) 1 C 45 NOAEC ( mg/ kg diet) 3000 1 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet)

Reported Chronic endpoint 30 2 Dose or Diet Rat Calculated Endpoint 1.5 mg/ kg bw based on standard FDA lab rat conversion Would you like to calculate an LD50 ft 2 for this use?

TREX MODEL INPUTS Page 2 Napropamide Upper Bound Kenaga Residues For RQ Calculation Acute and Chronic RQs are based on the Upper Bound Kenaga Residues.

Chemical Name: Naprop amide The maximum single day residue estimation is used for Use 0 both the acute and reproduction RQs. Formulation 0 Application Rate 4 lbs a. i./ acre Half life 35 days Application Interval 60 days Maximum # Apps./ Year 2 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration of Concern Avian acute LC50 C 46 Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Note: To provide risk management with the maximum possible information, Bobwhite quail LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentrationbased Bobwhite quail NOAEL ( mg/ kg bw) 0 RQs be calculated when data are available Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 Note: To provide risk management with the maximum possible information, LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentrationbased NOAEL ( mg/ kg bw) 1.5 RQs be calculated when data are available NOAEC ( mg/ kg diet) 30 EECs ( ppm) Kenaga Values Short Grass 1252.56 Tall Grass 574.09 Broadleaf plants/ sm Insects 704.57 Fruits/ pods/ seeds/ lg insects 78.29 Avian Results Avian Body % body wgt Adjusted Class Weight consume d LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g C 47 Short Grass 1428 814 363 Tall Grass 654 373 166 Broadleaf plants/ sm Insects 803 458 204 Fruits/ pods/ lg insects 89 51 23 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.61 0.28 0.09 Tall Grass 0.28 0.13 0.04 Broadleaf plants/ sm insects 0.35 0.15 0.05 Fruits/ pods/ lg insects 0.04 0.02 0.01 Dietary based RQs ( EEC/ LC50 or NOAEC) RQs Acute Chronic Short Grass # DIV/ 0! 0.42 Tall Grass # DIV/ 0! 0.19 Broadleaf plants/ sm Insects # DIV/ 0! 0.23 Fruits/ pods/ lg insects # DIV/ 0! 0.03 C 48 Napropamide 0 Upper bound Kenaga Residues Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 EEC equivalent dose ( mg/ kg bw) Mammalian Classes and Body weight Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 1190 827 188 Tall Grass 545 379 86 Broadleaf plants/ sm Insects 669 465 106 Fruits/ pods/ seeds/ lg insects 74 52 12 16 12 2 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.11 360.94 0.09 309.92 0.05 162.85 Tall Grass 0.05 165.43 0.04 142.05 0.02 74.64 Broadleaf plants/ sm insects 0.06 203.03 0.05 174.33 0.03 91.60 Fruits/ pods/ lg insects 0.01 22.56 0.01 19.37 0.00 10.18 C 49 Seeds ( granivore) 0.00 4.99 0.00 4.40 0.00 2.04 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 41.75 Tall Grass # DIV/ 0! 19.14 Broadleaf plants/ sm insects # DIV/ 0! 23.49 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 2.61 Mean Kenaga Residues For Risk Description Purposes Chemical Name: Naprop amide Use 0 Formulation 0 Application Rate 4 lbs a. i./ acre Half life 35 days Application Interval 60 days Maximum # Apps./ Year 2 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration of Concern Avian acute LC50 Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Bobwhite quail LC50 ( mg/ kg diet) 0 Bobwhite quail NOAEL ( mg/ kg bw) 0 Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet) 0 NOAEL ( mg/ kg bw) 1.5 NOAEC ( mg/ kg diet) 30 C 50 EECs ( ppm) Kenaga Values Short Grass 443.62 Tall Grass 187.88 Broadleaf plants/ sm Insects 234.86 Fruits/ pods/ seeds/ lg insects 36.53 Avian Results Avian Body % body wgt Adjusted Class Weight consume d LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g Short Grass 506 288 129 Tall Grass 214 122 54 Broadleaf plants/ sm Insects 268 153 68 Fruits/ pods/ lg insects 42 24 11 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.22 0.10 0.03 Tall Grass 0.09 0.04 0.01 Broadleaf plants/ sm insects 0.12 0.05 0.02 Fruits/ pods/ lg insects 0.02 0.01 0.00 Dietary based RQs C 51 RQs ( EEC/ LC50 or NOAEC)

Acute Chronic Short Grass # DIV/ 0! 0.15 Tall Grass # DIV/ 0! 0.06 Broadleaf plants/ sm Insects # DIV/ 0! 0.08 Fruits/ pods/ lg insects # DIV/ 0! 0.01 Napropamide 0 Mean Kenaga Residues Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 EEC Mammalian Classes and Body weight C 52 equivalent dose ( mg/ kg bw) Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 421 293 67 Tall Grass 178 124 28 Broadleaf plants/ sm Insects 223 155 35 Fruits/ pods/ seeds/ lg insects 35 24 5 8 5 1 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.04 127.83 0.03 109.76 0.02 57.68 Tall Grass 0.02 54.14 0.01 46.49 0.01 24.43 Broadleaf plants/ sm insects 0.02 67.68 0.02 58.11 0.01 30.53 Fruits/ pods/ lg insects 0.00 10.53 0.00 9.04 0.00 4.75 Seeds ( granivore) 0.00 2.33 0.00 2.05 0.00 0.95 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 14.79 Tall Grass # DIV/ 0! 6.26 Broadleaf plants/ sm insects # DIV/ 0! 7.83 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 1.22 6 lbs ai/ A banded once C 53 TREX MODEL INPUTS These values will be used in the calculation of exposure estimates for foliar, granular, liquid and/ or seed applications of pesticides.

Chemical Name: Napropamide Use:

Product name and form: % A. I.:

Application Rate: 2 Half life: 35 Application Interval:

Maximum # Apps./ Year: 1 Length of Simulation: 1 year Concentration of Concern: 2250 ( ppm)

Choose label: 1 Endpoints Avian Indicate test species below LD50 ( mg/ kg bw) 4640 2 LC50 ( mg/ kg diet) 1 NOAEL ( mg/ kg bw) 1 NOAEC ( mg/ kg diet) 3000 1 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet)

Reported Chronic endpoint 30 2 Dose or Diet Rat Calculated Endpoint 1.5 mg/ kg bw based on standard rat conversion Would you like to calculate an LD50 ft 2 for this use? 2 C 54 0%

TREX MODEL INPUTS Page 2 Napropamide Upper Bound Kenaga Residues For RQ Calculation Acute and Chronic RQs are based on the Upper Bound Kenaga Residues.

Chemical Name: Naprop amide The maximum single day residue estimation is used for Use 0 both the acute and reproduction RQs. Formulation 0 Application Rate 2 lbs a. i./ acre Half life 35 days Application Interval 0 days Maximum # Apps./ Year 1 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration of Concern Avian acute LC50 Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Note: To provide risk management with the maximum possible information, Bobwhite quail LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentrationbased Bobwhite quail NOAEL ( mg/ kg bw) 0 RQs be calculated when data are available Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 Note: To provide risk management with the maximum possible information, LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentrationbased NOAEL ( mg/ kg bw) 1.5 RQs be calculated when data are available NOAEC ( mg/ kg diet) 30 C 55 EECs ( ppm) Kenaga Values Short Grass 480.00 Tall Grass 220.00 Broadleaf plants/ sm Insects 270.00 Fruits/ pods/ seeds/ lg insects 30.00 Avian Results Avian Body % body wgt Adjusted Class Weight consume d LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g Short Grass 547 312 139 Tall Grass 251 143 64 Broadleaf plants/ sm Insects 308 176 78 Fruits/ pods/ lg insects 34 20 9 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.24 0.11 0.03 Tall Grass 0.11 0.05 0.02 Broadleaf plants/ sm insects 0.13 0.06 0.02 Fruits/ pods/ lg insects 0.01 0.01 0.00 Dietary based RQs C 56 RQs ( EEC/ LC50 or NOAEC)

Acute Chronic Short Grass # DIV/ 0! 0.16 Tall Grass # DIV/ 0! 0.07 Broadleaf plants/ sm Insects # DIV/ 0! 0.09 Fruits/ pods/ lg insects # DIV/ 0! 0.01 Napropamide 0 Upper bound Kenaga Residues Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 EEC Mammalian Classes and Body weight C 57 equivalent dose ( mg/ kg bw) Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 456 317 72 Tall Grass 209 145 33 Broadleaf plants/ sm Insects 257 178 41 Fruits/ pods/ seeds/ lg insects 29 20 5 6 5 1 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.04 138.32 0.04 118.77 0.02 62.41 Tall Grass 0.02 63.40 0.02 54.43 0.01 28.60 Broadleaf plants/ sm insects 0.02 77.80 0.02 66.81 0.01 35.10 Fruits/ pods/ lg insects 0.00 8.64 0.00 7.42 0.00 3.90 Seeds ( granivore) 0.00 1.91 0.00 1.69 0.00 0.78 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 16.00 Tall Grass # DIV/ 0! 7.33 Broadleaf plants/ sm insects # DIV/ 0! 9.00 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 1.00 C 58 Mean Kenaga Residues For Risk Description Purposes Chemical Name: Naprop amide Use 0 Formulation 0 Application Rate 2 lbs a. i./ acre Half life 35 days Application Interval 0 days Maximum # Apps./ Year 1 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration of Concern Avian acute LC50 Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Bobwhite quail LC50 ( mg/ kg diet) 0 Bobwhite quail NOAEL ( mg/ kg bw) 0 Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet) 0 NOAEL ( mg/ kg bw) 1.5 NOAEC ( mg/ kg diet) 30 EECs ( ppm) Kenaga Values Short Grass 170.00 Tall Grass 72.00 Broadleaf plants/ sm Insects 90.00 Fruits/ pods/ seeds/ lg insects 14.00 Avian Results Avian Body % body wgt Adjusted Class Weight consume d LD50 Small 20 114 2326 C 59 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g Short Grass 194 111 49 Tall Grass 82 47 21 Broadleaf plants/ sm Insects 103 59 26 Fruits/ pods/ lg insects 16 9 4 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.08 0.04 0.01 Tall Grass 0.04 0.02 0.00 Broadleaf plants/ sm insects 0.04 0.02 0.01 Fruits/ pods/ lg insects 0.01 0.00 0.00 Dietary based RQs ( EEC/ LC50 or NOAEC) RQs Acute Chronic Short Grass # DIV/ 0! 0.06 Tall Grass # DIV/ 0! 0.02 Broadleaf plants/ sm Insects # DIV/ 0! 0.03 Fruits/ pods/ lg insects # DIV/ 0! 0.00 C 60 Napropamide 0 Mean Kenaga Residues Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 EEC equivalent dose ( mg/ kg bw) Mammalian Classes and Body weight Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 162 112 26 Tall Grass 68 48 11 Broadleaf plants/ sm Insects 86 59 14 Fruits/ pods/ seeds/ lg insects 13 9 2 3 2 0 Dose based RQs ( daily dose/ LD50 or 15 g mammal 35 g mammal 1000 g mammal C 61 NOAEL)

Acute Chronic Acute Chronic Acute Chronic Short Grass 0.01 48.99 0.01 42.06 0.01 22.10 Tall Grass 0.01 20.75 0.01 17.81 0.00 9.36 Broadleaf plants/ sm insects 0.01 25.93 0.01 22.27 0.00 11.70 Fruits/ pods/ lg insects 0.00 4.03 0.00 3.46 0.00 1.82 Seeds ( granivore) 0.00 0.89 0.00 0.79 0.00 0.36 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 5.67 Tall Grass # DIV/ 0! 2.40 Broadleaf plants/ sm insects # DIV/ 0! 3.00 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 0.47 6 lb ai/ a broadcast once TREX MODEL INPUTS These values will be used in the calculation of exposure estimates for foliar, granular, liquid and/ or seed applications of pesticides.

Chemical Name: Napropamide Use:

Product name and form: % A. I.:

Application Rate: 6 Half life: 35 Application Interval:

Maximum # Apps./ Year: 1 C 62 Length of Simulation: 1 year Concentration of Concern: 2250 ( ppm)

Choose label: 1 Endpoints Avian Indicate test species below LD50 ( mg/ kg bw) 4640 2 LC50 ( mg/ kg diet) 1 NOAEL ( mg/ kg bw) 1 NOAEC ( mg/ kg diet) 3000 1 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet)

Reported Chronic endpoint 30 2 Dose or Diet Rat Calculated Endpoint 1.5 mg/ kg bw based on standard rat conversion Would you like to calculate an LD50 ft 2 for this use? 2 0%

TREX MODEL INPUTS Page 2 Napropamide Upper Bound Kenaga Residues For RQ Calculation Acute and Chronic RQs are based on the Upper Bound C 63 Kenaga Residues.

Chemical Name: Naprop amide The maximum single day residue estimation is used for Use 0 both the acute and reproduction RQs. Formulation 0 Application Rate 6 lbs a. i./ acre Half life 35 days Application Interval 0 days Maximum # Apps./ Year 1 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration of Concern Avian acute LC50 Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Note: To provide risk management with the maximum possible information, Bobwhite quail LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentrationbased Bobwhite quail NOAEL ( mg/ kg bw) 0 RQs be calculated when data are available Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 Note: To provide risk management with the maximum possible information, LC50 ( mg/ kg diet) 0 it is recommended that both the dose based and concentrationbased NOAEL ( mg/ kg bw) 1.5 RQs be calculated when data are available NOAEC ( mg/ kg diet) 30 EECs ( ppm) Kenaga Values Short Grass 1440.00 Tall Grass 660.00 Broadleaf plants/ sm Insects 810.00 Fruits/ pods/ seeds/ lg insects 90.00 Avian Results C 64 Avian Body % body wgt Adjusted Class Weight consume d LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g Short Grass 1642 936 418 Tall Grass 752 429 191 Broadleaf plants/ sm Insects 923 527 235 Fruits/ pods/ lg insects 103 59 26 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.71 0.32 0.10 Tall Grass 0.32 0.14 0.05 Broadleaf plants/ sm insects 0.40 0.18 0.06 Fruits/ pods/ lg insects 0.04 0.02 0.01 Dietary based RQs ( EEC/ LC50 or NOAEC) RQs Acute Chronic Short Grass # DIV/ 0! 0.48 Tall Grass # DIV/ 0! 0.22 Broadleaf plants/ sm Insects # DIV/ 0! 0.27 Fruits/ pods/ lg insects # DIV/ 0! 0.03 C 65 Napropamide 0 Upper bound Kenaga Residues Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 EEC equivalent dose ( mg/ kg bw) Mammalian Classes and Body weight Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 1368 950 216 Tall Grass 627 436 99 Broadleaf plants/ sm Insects 770 535 122 Fruits/ pods/ seeds/ lg insects 86 59 14 19 14 3 C 66 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.12 414.95 0.11 356.30 0.06 187.22 Tall Grass 0.06 190.19 0.05 163.30 0.03 85.81 Broadleaf plants/ sm insects 0.07 233.41 0.06 200.42 0.03 105.31 Fruits/ pods/ lg insects 0.01 25.93 0.01 22.27 0.00 11.70 Seeds ( granivore) 0.00 5.73 0.00 5.06 0.00 2.34 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 48.00 Tall Grass # DIV/ 0! 22.00 Broadleaf plants/ sm insects # DIV/ 0! 27.00 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 3.00 Mean Kenaga Residues For Risk Description Purposes Chemical Name: Naprop amide Use 0 Formulation 0 Application Rate 6 lbs a. i./ acre Half life 35 days Application Interval 0 days Maximum # Apps./ Year 1 Length of Simulation 1 year Concentration of Concern 2250.00 ( ppm)

Name of Concentration Avian acute LC50 C 67 of Concern Endpoints Avian Mallard duck LD50 ( mg/ kg bw) 4640 Bobwhite quail LC50 ( mg/ kg diet) 0 Bobwhite quail NOAEL ( mg/ kg bw) 0 Bobwhite quail NOAEC ( mg/ kg diet) 3000 Mammals LD50 ( mg/ kg bw) 5000 LC50 ( mg/ kg diet) 0 NOAEL ( mg/ kg bw) 1.5 NOAEC ( mg/ kg diet) 30 EECs ( ppm) Kenaga Values Short Grass 510.00 Tall Grass 216.00 Broadleaf plants/ sm Insects 270.00 Fruits/ pods/ seeds/ lg insects 42.00 Avian Results Avian Body % body wgt Adjusted Class Weight consume d LD50 Small 20 114 2326 Mid 100 65 2960 Large 1000 29 4182 EEC equivalent dose ( mg/ kg bw) Avian Classes and Body Weights small mid large 20 g 100 g 1000 g Short Grass 581 332 148 Tall Grass 246 140 63 Broadleaf plants/ sm Insects 308 176 78 C 68 Fruits/ pods/ lg insects 48 27 12 Dose based RQs ( daily dose/ LD50) Avian Acute RQs 20 g 100 g 1000 g Short Grass 0.25 0.11 0.04 Tall Grass 0.11 0.05 0.01 Broadleaf plants/ sm insects 0.13 0.06 0.02 Fruits/ pods/ lg insects 0.02 0.01 0.00 Dietary based RQs ( EEC/ LC50 or NOAEC) RQs Acute Chronic Short Grass # DIV/ 0! 0.17 Tall Grass # DIV/ 0! 0.07 Broadleaf plants/ sm Insects # DIV/ 0! 0.09 Fruits/ pods/ lg insects # DIV/ 0! 0.01 Napropamide 0 Mean Kenaga Residues C 69 Mammalian Results Mammalian Body % body wgt Adjusted Adjusted Class Weight consume d LD50 NOAEL 15 95 10989 3 Herbivores/ 35 66 8891 3 insectivores 1000 15 3846 1 15 21 10989 3 Grainvores 35 15 8891 3 1000 3 3846 1 EEC equivalent dose ( mg/ kg bw) Mammalian Classes and Body weight Herbivores/ insectivores Granivore s 15 g 35 g 1000 g 15 g 35 g 1000 g Short Grass 485 337 77 Tall Grass 205 143 32 Broadleaf plants/ sm Insects 257 178 41 Fruits/ pods/ seeds/ lg insects 40 28 6 9 6 1 Dose based RQs ( daily dose/ LD50 or NOAEL) 15 g mammal 35 g mammal 1000 g mammal Acute Chronic Acute Chronic Acute Chronic Short Grass 0.04 146.96 0.04 126.19 0.02 66.31 Tall Grass 0.02 62.24 0.02 53.44 0.01 28.08 Broadleaf plants/ sm insects 0.02 77.80 0.02 66.81 0.01 35.10 Fruits/ pods/ lg insects 0.00 12.10 0.00 10.39 0.00 5.46 Seeds ( granivore) 0.00 2.68 0.00 2.36 0.00 1.09 C 70 Dietary based RQs ( EEC/ LC50 or NOAEC) Mammal RQs Acute Chronic Short Grass # DIV/ 0! 17.00 Tall Grass # DIV/ 0! 7.20 Broadleaf plants/ sm insects # DIV/ 0! 9.00 Fruits/ pods/ seeds/ lg insects # DIV/ 0! 1.40 E 1 APPENDIX E. SUMMARY OF ECOTOXICITY DATA Ecological Effects Data Requirements for Napropamide Guideline # Data Requirement Is Data Requirement Satisfied? MRID #' s Study Classification 71 1 Avian Oral LD50 yes MRID 79548 and 79555 core 71 2 Avian Dietary LC50 yes 435067 01 core 49497 supplemental 25893 core 39775 and 49497 invalid 258393 and 113820 core 416102 03 core 25894 supplemental 125894 and 113819 core Accession 093519 supplemental Accession supplemental 093519 Stauffer Chem. Comp. core 71 4 Avian Reproduction yes 420813 01 420277 01 core 72 1 Freshwater Fish LC50 yes 39772 Invalid 39772 Invalid 39773 and 118002 Invalid E 2 416102 04 Core 093519 Acc. No. Core 093519 Acc. No. Invalid 093519 Acc. No. Invalid 093519 Acc. No. Core 093519 Acc. No. Core Stauffer Chemical Core 115313 Core 115313 and 25895 Supplemental Invalid 093519 Acc. No. Invalid 093519 Acc. No. Invalid 39771 and 49496 Supplemental 39771 and 49496 Supplemental 72686 Supplemental 72 2 Freshwater Invertebrate Acute LC50 yes 88064 and 57805 core 416102 05 core 72 3( a) Estuarine/ Marine Fish LC50 yes 416102 06 core 72 3( b) Estuarine/ Marine Mollusk EC50 yes 416671 01 core 65360 invalid 72 3( c) Estuarine/ Marine Shrimp EC50 yes 416102 07 core Acc. No 229228 Invalid Acc. No 229228 Invalid 72 4( a) Freshwater Fish Early Life Stage no 464591 09 supplemental E 3 72 4( b) Aquatic Invertebrate Life Cycle yes 464787 04 core 72 5 Freshwater Fish Full Life Cycle no Not submitted Not submitted 123 1( a) Seedling Emergence yes 416102 09 core 464591 13 supplemental 464591 14 invalid 123 1( b) Vegetative Vigor yes 416102 09 core 123 2 Aquatic Plant Growth partially 416102 10 core 464591 11 supplemental 464591 12 supplemental 144 1 Honey Bee Acute Contact LD50 yes 464591 16 invalid 464591 15 invalid Honey Bee Acute Oral LD50 464591 15 supplemental 141 2 Honey Bee Residue on Foliage not required NA NA F 1 Appendix F. Ecological Effects Data for Napropamide ECOLOGICAL EFFECTS CHARACTERIZATION Toxicity to Terrestrial Animals Avian Acute Oral Toxicity Since the LD 50 values are > 2000 mg/ kg ( Table 1), Napropamide is classified as practically non toxic to upland game bird species on an acute oral basis.

Table 1. Acute oral toxicity of Napropamide to Avian Species.

Species % ai LD 50 ( mg/ kg) Toxicity Category MRID or Acc. No. Study Classification Mallard Duck ( Anas platyrhynchos) 94.6 4640 Practically non toxic 79548 and 79555 Core 1Core ( study satisfies guideline). Supplemental ( study is scientifically sound, but does not satisfy guideline)

Avian Subacute Dietary Toxicity Since the LC 50 values are > 5000 ppm ( Table 2), Napropamide is classified as practically non toxic to avian species on a subacute dietary basis. F 2 Table 2. Subacute dietary toxicity of Napropamide to Northern Bobwhite Quail and Mallard Ducks.

Species % AI 8 Day LC 50 ( ppm) 1 Toxicity Category MRID or Acc. No. Author/ Year Study Classification Bobwhite quail ( Colinus virginianus) 94.9 > 2250 Practically non toxic 435067 01 Core Bobwhite quail ( Colinus virginianus) 97.8 > 5600 Practically non toxic 49497 Supplemental Bobwhite quail ( Colinus virginianus) 87 > 5620 Practically non toxic 25893 Core Bobwhite quail ( Colinus virginianus) 97.8 > 56000 Practically non toxic 39775 and 49497 Invalid Bobwhite quail ( Colinus virginianus 97.8 > 5620 Practically non toxic 258393 and 113820 Core Mallard duck ( Anas platyrhynchos) 95.2 > 5620 Practically non toxic 416102 03 Core Mallard duck ( Anas platyrhynchos) 97.8 > 10,000 Practically non toxic 25894 Supplemental 1 Mallard duck ( Anas platyrhynchos) 97.8 > 3000 Practically non toxic 25894 and 113819 Core Bobwhite quail ( Colinus virginianus 50 > 32000 Practically non toxic 79548 Supplemental Bobwhite quail ( Colinus virginianus 97.8 > 56000 Practically non toxic 79555 Supplemental Mallard duck ( Anas platyrhynchos) 97.8 > 7200 Practically non toxic Stauffer Chem. Comp. Core Avian Chronic Species/ Study Type % ai Test Type Toxicity NOAEC ( mg/ kg) Affected Endpoints MRID No. Classification Bobwhite quail ( Colinus virginianus) 95.2 Reproduction 3000 NA 1 420813 01 Core Mallard duck ( Anas platyrhynchos) 95.2 Reproduction 10002 Reduced Body Weight2 420277 01 Core 1 No endpoints were significantly effected. The NOAEC occurred at the highest concentration tested. Therefore, this NOEAC will not be used to calculate an RQ. 2 The effect demonstrated on body weight was deemed not related to the toxicant effects of napropamide. This is because the effects was only demonstrated in the 3000 ppm males during the last two weeks of the study. The differences observed were slight, and appeared to be related to a slightly lighter initial body weight of the males in this group. Furthermore, there were no significant differences in mean body weight change between the control group and the 3000 ppm treatment group at any time during the course of the study. Therefore, EFED conclusion is that a LOAEC was not established in the study. Therefore, this NOEAC will not be used to calculate an RQ. F 3 Mammal, acute and chronic Based on the available data ( Table 3), Napropamide is practically non toxic to small mammals on an acute oral basis with an LD50 of rat.

Table 3. Mammalian toxicity data for rats exposed to Napropamide.

Species/ Study Type % ai Toxicity Value Affected Endpoints MRID No. or Acc. # Classification Rat acute oral Tech. > 5000 mg/ kg ( LD50) Mortality MRID 40362902 Core Multi generation Reproduction and Fertility Study Tech. 100 ppm ( LOEL) 30 ppm ( NOAEL) Decreased body weight MRID 92125069 Core Toxicity to Non target Insects Two guideline studies that were submitted to determine the toxicity to non target insects have been determined to be invalid ( Table 4). One study contained data on acute oral toxicity to honeybees, and has been classified as supplemental. Based on the data contained in this study, Napropamide is practically non toxic to honey bees on an acute oral basis.

Table 4. Non target insect toxicity data for honeybees exposed to Napropamide.

Species/ Study Type % ai Toxicity Value Affected Endpoints MRID No. or Acc. # Classification Honeybee acute contact Not reported Not reported Mortality MRID 464591 15 Invalid Honeybee acute oral toxicity Not reported > 113.5 ug/ bee ( LD50) Mortality MRID 464591 15 Supplementa l Honeybee acute contact 50 Not reported Mortality MRID 464591 16 Invalid Toxicity to Freshwater Aquatic Animals Freshwater Fish, Acute Since the TGAI LC 50 for freshwater fish ranges from 29 to 6.4 ppm, the TGAI of Napropamide is categorized as moderately to slightly toxic to freshwater fish on an acute basis ( Table 5). F 4 Table 5. Acute Toxicity of Napropamide to Freshwater Fish.

Species % AI 96 hour LC50 ( ppm) Toxicity Category MRID, Acc. No., or Reference Study Classification Bluegill Sunfish ( Lepomis macrohirus) 98.5 29 Slightly Toxic 39772 MRID Invalid Bluegill Sunfish ( Lepomis macrohirus) 50 13.3 Slightly Toxic 39772 MRID Invalid Bluegill Sunfish ( Lepomis macrohirus) 97.8 12.6 ( 144 hr.) Slightly Toxic 39773 and 118002 MRID Invalid Bluegill Sunfish ( Lepomis macrohirus) 98.5 12 Slightly Toxic 416102 04 MRID Core Bluegill Sunfish ( Lepomis macrohirus) 95.2 18 Slightly Toxic 093519 Acc. No. Core Bluegill Sunfish ( Lepomis macrohirus) 50 ( R 7465 Devrinol Technical) 13.5 Slightly Toxic 093519 Acc. No. Invalid Bluegill Sunfish ( Lepomis macrohirus) 97.5 30 Slightly Toxic 093519 Acc. No. Invalid Bluegill Sunfish ( Lepomis macrohirus) 97.8 18 ( 24hr) Slightly Toxic 093519 Acc. No. Core Bluegill Sunfish ( Lepomis macrohirus) 97.8 12.2 ( 144 hr LC50) Slightly Toxic 093519 Acc. No. Core Rainbow trout ( Salmo gairdneri) 97.8 9.4 Moderately Toxic Stauffer Chemical Core Rainbow trout ( Salmo gairdneri) 97.8 6.4 Moderately Toxic 115313 MRID Core Rainbow trout ( Salmo gairdneri) Tech. 13.4 Slightly Toxic 115313 and 25895 MRID Supplemental Rainbow trout ( Salmo gairdneri) 50 ( R 7465 Devrinol Technical) 10.7 Slightly Toxic 093519 Acc. No. Invalid Rainbow trout ( Salmo gairdneri) 97.8 16.6 Slightly Toxic 093519 Acc. No. Invalid Table 5. Acute Toxicity of Napropamide to Freshwater Fish.

Species % AI 96 hour LC50 ( ppm) Toxicity Category MRID, Acc. No., or Reference Study Classification F 5 Rainbow trout ( Salmo gairdneri) 97.8 18.1 Slightly Toxic 39771 and 49496 MRIDs Supplemental Rainbow trout ( Salmo gairdneri) 50 10.1 Slightly Toxic 39771 and 49496 MRIDs Supplemental Rainbow trout ( Salmo gairdneri) Tech. 9.3 Moderately Toxic 72686 MRID Supplemental Freshwater Fish, Chronic A chronic toxicity test using the TGAI is required to establish the toxicity of Napropamide to freshwater fish ( Table 6).

Table 6. Freshwater Invertebrate Chronic Toxicity for Napropamide Species % AI NOEC/ LOEC ( ppm) Most Sensitive Endpoint MRID Study Classification Rainbow trout ( Oncorhynchus mykiss) 94.0 1.9 / 3.2 Terminal growth ( length and weight) MRID 464591 09 Supplemental Freshwater Invertebrates, Acute A freshwater aquatic invertebrate toxicity test using the TGAI is required to establish the toxicity of Napropamide is slightly to aquatic invertebrates. The preferred test species is Daphnia magna. Results indicate that Napropamide is slightly toxic to freshwater invertebrates ( Table 7).

Table 7. Freshwater Invertebrate Acute Toxicity for Napropamide Species % AI 48 hour EC50 ( ppm) Toxicity Category MRID or Acc. No. Author/ Year Study Classification Water flea ( Daphnia magna) 94.6 14.3 Slightly MRID 88064 and 57805 Core Water flea ( Daphnia magna) Tech. 24.7 Slightly MRID 416102 05 Core F 6 Freshwater Invertebrate, Chronic A freshwater aquatic invertebrate chronic test using the TGAI is required to establish the toxicity of Napropamide to aquatic invertebrates. The preferred test species is Daphnia magna ( Table 8).

Table 8. Freshwater Invertebrate Chronic Toxicity for Napropamide Species % AI NOEC/ LOEC ( ppm) Most Sensitive Endpoint MRID Study Classification Water flea ( Daphnia magna) 94.0  94.2 2.2 / 1.1 Growth ( length) MRID 464787 04 Core Toxicity to Estuarine and Marine Aquatic Animals Estuarine and Marine Fish, Acute Acute toxicity testing with estuarine/ marine fish using the TGAI is required for Napropamide because the use may be associated with estaurine or marine habitats. The preferred test species is sheepshead minnow. The LC 50 value indicates that Napropamide is slightly toxic on an acute basis to estuarine/ marine fish ( Table 9).

Table 9. Acute Toxicity of Napropamide to Estuarine/ Marine Fish.

Species % AI 96 hour LC 50 ( ppm) Toxicity Category MRID or Acc. No. Author/ Year Study Classification Sheepshead minnow ( Cyprinodon variegatus) 95.2 14 Slightly Toxic MRID 416102 06 Core Estuarine and Marine Invertebrates, Acute Acute toxicity testing with estuarine/ marine invertebrate using the TGAI is required for Napropamide because the use site may be associated with estaurine or marine habitat. The preferred test species are mysid shrimp and eastern oyster. The EC 50 value for Napropamide indicates that the TGAI is moderately toxic on an acute basis to estuarine/ marine eastern oyster ( Table 10). The LC 50 value for Napropamide indicates that the TGAI is practically non toxic to moderately toxic on an acute basis to the mysid shrimp.

Table 10. Acute Toxicity of Napropamide to Estuarine/ Marine Invertebrates.

Species % AI 96 hour EC50 ( ppm) Toxicity Category MRID or Acc. No. Author/ Year Study Classification Eastern Oyster Tech. 1.4 Moderately Toxic MRID 416671 01 Core Mysidopis bahia Tech. 4.2 Moderately Toxic MRID 416102 07 Core F 7 Easter Oyster larvae 97.4 Not Obtained NA 65360 Invalid Pink Shrimp 97.4 18 Slightly Toxic 65360 Invalid Fiddler Crab 97.4 > 100 Practically nontoxic 65360 Invalid Toxicity to Non Target Plants Terrestrial Plants Tier II phytotoxicity tests measured the response of plants to Napropamide, relative to a control, and five or more test concentrations. Results from the Tier II toxicity testing on the technical/ TEP material are reported in Table 11.

Table 11. Terrestrial Non Target Plant Toxicity Data ( Tier II) for Napropamide.

Type of Test Most sensitive species EC 25 ( lb ai/ A) EC05 ( lb ai/ a) Parameter MRID No. Author/ Year Study Classification Seedling Germination NC1 NC NC NC 416102 09 Invalid Seedling Emergence Avena fatua ( Monocot species) 0.1144 0.029 Dry weight 416102 09 Core Seedling Emergence Beta vulgaris ( Dicot) 0.00352 0.000001848 Dryweight 416102 09 Core Vegetative Avena fatua ( Monocot) 0.8008 0.3344 Dry weight 416102 09 Core Vegetative Beta vulgaris ( Dicot) 546 0.000000132 Dry weight 416102 09 Core Toxicity to Aquatic Plants Aquatic plant testing is required for Napropamide because aerial application and outdoor nonresidential aquatic use will expose non target aquatic plants to Napropamide. EFED has aquatic plant toxicity data for Selenastrum capricornutum, Lemna minor, and Anabaena sp. ( Table 12); however, data were not submitted for the following algal and aquatic plants species: Lemna gibba, Skeletonema costatum, and a freshwater diatom, usually Navicula pelliculosa). Therefore, EFED cannot fully assess potential adverse effects to aquatic plants and algae.

Table 12. Nontarget Aquatic Plant Toxicity ( Tier II) for Napropamide Species % AI EC50/ EC05 ( ppm) MRID No. Author/ Year Study Classification Selenastrum capricornumtum 45 3.4 416102 10 Core Table 12. Nontarget Aquatic Plant Toxicity ( Tier II) for Napropamide Species % AI EC50/ EC05 ( ppm) MRID No. Author/ Year Study Classification F 8 Lemna minor 93.2 0.35 / 0.036 464591 11 Supplemental Anabaena sp. 93.2 13.0 / 1.8 464591 12 Supplemental G 1 APPENDIX G. ENDANGERED SPECIES Table G 1: Number of endangered plant and mammal species by state for each crop group Crop Group Sta te # of endange red plants # of endange red mammal s Nuts AL 17 4 AZ 11 8 AR 1 1 CA 165 21 FL 20 7 GA 14 2 ID 0 3 KS 2 2 KY 2 2 LA 1 2 M 0 1 MS 2 1 M 5 2 NE 1 0 NV 7 0 N 8 5 NC 9 4 OH 0 1 OK 2 3 OR 8 1 SC 18 3 TN 9 4 TX 19 3 UT 4 1 VA 3 2 W 3 4 Berries Berries ( cont) AL 16 4 AZ 7 4 AR 2 3 CA 169 21 CO 4 2 CT 2 2 DE 2 2 FL 39 8 GA 15 4 ID 3 3 IL 6 1 IN 0 2 IA 4 1 KS 2 2 KY 3 2 LA 1 1 ME 3 2 M 6 3 M 3 2 MI 6 2 M 4 1 MS 1 1 M 6 2 MT 2 2 NE 1 0 NV 7 0 NH 2 1 NJ 5 2 N 6 1 NY 6 2 NC 25 6 OH 4 1 OK 1 3 OR 9 1 PA 2 2 RI 2 2 SC 17 3 SD 1 0 TN 12 4 TX 13 3 UT 14 2 VT 2 1 VA 11 6 W 4 4 W 5 4 WI 6 1 Brassica AL 4 2 AZ 3 2 AR 2 2 CA 155 21 CO 4 2 CT 2 2 DE 1 1 FL 27 5 GA 4 1 HI 134 2 IL 4 1 IN 1 2 IA 4 1 KS 0 1 KY 3 2 LA 1 1 ME 3 2 M 5 3 M 2 2 MI 5 2 M 3 1 MS 0 1 M 4 2 MT 1 2 NE 1 0 NH 1 1 NJ 5 2 Crop Group Sta te # of endange red plants # of endange red mammal s G 2 N 4 1 NY 6 2 NC 21 6 OH 4 1 OK 0 1 OR 7 1 PA 2 2 RI 1 1 SC 10 3 TN 6 2 Crop Group Sta te # of endange red plants # of endange red mammal s Brassica ( cont) TX 8 3 VT 2 1 VA 5 3 W 2 3 W 1 1 WI 6 0 Citrus AL 3 1 AZ 4 3 CA 155 20 CT 0 1 FL 42 6 HI 134 2 M 2 2 M 1 1 MI 2 0 NJ 2 1 NY 0 2 NC 0 2 OH 0 1 OR 7 0 PA 1 2 TX 3 2 VA 0 1 W 2 3 Stone Fruits AL 16 4 AZ 11 8 AR 4 3 CA 165 21 CO 6 2 CT 2 2 DE 1 2 FL 23 3 GA 12 2 ID 3 3 IL 4 2 IN 0 2 IA 3 1 KS 2 2 KY 4 2 LA 1 2 ME 0 1 M 5 3 M 3 1 MI 6 1 M 0 1 MS 1 1 M 7 2 MT 2 2 NV 7 0 NH 1 1 NJ 5 2 N 10 2 NY 6 2 NC 22 5 OH 4 1 OK 2 3 OR 10 1 PA 2 2 RI 1 2 SC 18 1 SD 1 0 TN 15 4 TX 13 3 UT 18 2 VT 1 0 VA 11 5 W 6 4 Crop Group Sta te # of endange red plants # of endange red mammal s G 3 W 4 2 WI 4 0 Pome Fruits AL 17 4 AZ 15 8 AR 1 3 CA 176 22 CO 7 2 CT 2 2 DE 2 1 FL 10 4 GA 14 2 ID 3 3 IL 6 2 IN 1 2 IA 5 1 KS 2 2 KY 9 3 LA 1 1 ME 1 2 M 5 3 M 3 1 MI 7 2 M 4 1 MS 1 1 M 7 2 MT 2 2 NE 1 0 NV 8 0 NH 2 1 NJ 5 2 N 13 2 NY 6 2 NC 22 5 OH 4 1 OK 1 3 OR 13 1 PA 2 2 RI 2 2 SC 17 1 SD 1 0 TN 19 4 TX 10 2 SC 17 1 SD 1 0 TN 19 4 TX 10 2 UT 23 2 VT 2 1 VA 12 6 W 6 4 W 5 5 WI 6 1 W 0 3 Crop Group Sta te # of endange red plants # of endange red mammal s Fruiting Vegetables AL 13 4 AZ 8 6 AR 2 3 CA 168 21 CO 6 2 CT 2 2 DE 2 2 FL 39 7 GA 11 2 HI 134 2 ID 2 3 IL 6 2 IN 1 2 IA 5 1 KS 2 1 KY 7 2 LA 2 1 ME 3 2 M 6 3 M 3 2 MI 6 2 M 2 1 MS 0 1 M 6 2 MT 1 2 NE 1 1 NV 7 0 NH 2 1 NJ 5 2 N 11 5 NY 6 2 NC 24 5 OH 4 1 OK 1 3 OR 7 1 PA 2 2 G 4 RI 2 2 SC 15 3 SD 1 0 TN 13 4 TX 10 3 UT 11 2 VT 2 1 VA 9 6 W 4 4 W 3 1 WI 6 1 Tropical Fruits AL 2 2 AZ 3 2 CA 159 21 FL 20 5 GA 1 1 HI 134 2 LA 1 1 MS 0 1 NC 0 1 OR 3 1 SC 0 1 TX 7 3 VA 0 1 W 0 2 Misc. Crops AL 6 3 AR 1 0 CA 63 9 CT 1 1 FL 8 4 GA 5 3 HI 134 2 IN 1 2 KS 2 0 KY 10 3 LA 0 1 ME 1 1 M 2 3 M 1 1 MI 3 0 MS 1 1 M 3 2 NJ 4 2 NY 2 2 NC 27 6 OH 1 1 OR 1 0 PA 2 2 SC 14 1 TN 15 4 TX 0 1 VA 7 6 W 0 2 W 1 1 WI 3 0 Oil Seed Crops CA 103 17 IN 1 1 MT 1 2 OR 4 0 W 0 3 WI 2 0 Trees/ Ornamentals AL 16 4 AZ 13 8 AR 1 3 CA 174 22 CO 8 2 CT 2 2 DE 2 2 FL 49 8 GA 16 4 HI 134 2 ID 1 4 IL 8 2 IN 2 2 IA 6 1 KS 2 2 KY 5 3 LA 1 1 ME 3 2 M 5 3 M 3 2 MI 7 2 M 4 1 MS 1 1 M 7 2 MT 2 2 NE 2 1 NH 2 1 NJ 5 2 N 12 1 NY 6 2 NC 26 6 OH 4 1 OK 1 3 OR 11 1 PA 2 2 RI 2 2 SC 18 3 SD 1 1 TN 16 4 TX 11 3 UT 20 2 VT 2 1 VA 12 6 W 6 4 W 5 3 WI 6 1 W 2 4 Nuts ( almond, pistachio, pecan, filbert, walnut) G 5 Berries/ small fruit ( blackberry, boysenberry, loganberry, raspberry, blueberry, strawberry, cranberry, currant, grape) Brassica and leafy vegetables ( broccoli, brussels sprouts, cabbage, cauliflower, asparagus) Citrus ( grapefruit, lemon, nectarine, orange, tangerine, tangelo) Stone fruit ( apricot, cherry, peach, plum, prune) Pome fruit ( apple, pear) Fruiting vegetables ( eggplant, pepper, tomato) Tropical fruit ( fig, kiwi fruit, persimmon, avocado, pomegranate) Additional crops ( artichoke, rhubarb, tobacco, sweet potato) Oil seed crops ( mint, olive) Trees/ ornamentals ( conifer, shade tree, ornamental tree, ground cover, herbaceous plants, woody shrubs, vines, lawns, turf, potting soil) G 6 Table G 2. List of endangered plant species potentially at risk from napropamide use SPECIES NAME STATE ( S)

ACHYRANTHES MUTICA ( NCN) HI ADOBE SUNBURST, SAN JOAQUIN CA A'E ( ZANTHOXYLUM DIPETALUM VAR. TOMENTOSUM) HI A'E ( ZANTHOXYLUM HIENSE) HI AGAVE, AZ AZ ' AIEA ( NOTHOCESTRUM BREVIFLORUM) HI ' AIEA ( NOTHOCESTRUM PELTATUM) HI ' AKOKO ( EUPHORBIA HAELEELEANA) HI ALANI ( MELICOPE HAUPUENSIS) HI ALANI ( MELICOPE KNUDSENII) HI ALANI ( MELICOPE PALLIDA) HI ALANI ( MELICOPE QUADRANGULARIS) HI ALANI ( MELICOPE ZAHLBRUCKNERI) HI ALLOCARYA, CALISTOGA CA ALOPECURUS, SONOMA CA ALSINIDENDRON VISCOSUM ( NCN) HI AMARANTH, SEABEACH NY, NC AMBROSIA, SAN DIEGO CA AMBROSIA, SOUTH TX TX Amole, Camatta Canyon CA AMOLE, PURPLE CA AMPHIANTHUS, LITTLE AL, GA, SC ' ANUNU ( SICYOS ALBA) HI ARROWHEAD, BUNCHED NC, SC ASPLENIUM FRAGILE VAR. INSULARE ( NCN) HI ASTER, DECURRENT FALSE IL, MO ASTER, DEL MAR SAND CA ASTER, FL GOLDEN FL ASTER, RUTH'S GOLDEN TN AUPAKA ( ISODENDRION HOSAKAE) HI AUPAKA ( ISODENDRION LAURIFOLIUM) HI AUPAKA ( ISODENDRION LONGIFOLIUM) HI AVENS, SPREADING NC, TN ' AWIWI ( CENTAURIUM SEBAEOIDES) HI ' AWIWI ( HEDYOTIS COOKIANA) HI AYENIA, TX TX BACCHARIS, ENCINITAS CA BARBARA'S BUTTONS, MOHR'S AL, GA BARBERRY, ISLAND CA BARBERRY, NEVIN'S CA BEAKED RUSH, KNIESKERN'S NJ BEARGRASS, BRITTON'S FL BEAR POPPY, DWARF UT BEDSTRAW, EL DORADO CA BEDSTRAW, ISLAND CA BELLFLOWER, BROOKSVILLE FL G 7 BIRCH, VA ROUND LEAF VA BIRD'S BEAK, PALMATE BRACTED CA BIRD'S BEAK, PENNELL'S CA BIRD'S BEAK, SALT MARSH CA BIRD'S BEAK, SOFT CA BIRDS IN A NEST, WHITE FL BITTERCRESS, SMALL ANTHERED NC, VA BLADDERPOD, KODACHROME UT BLADDERPOD, LYRATE AL BLADDERPOD, MO AR, MO BLADDERPOD, SAN BERNARDINO MOUNTAINS CA BLADDERPOD, SPRING CREEK TN BLADDERPOD, WHITE TX BLADDERPOD, ZAPATA TX BLAZING STAR, ASH MEADOWS NV BLAZING STAR, HELLER'S NC BLAZING STAR, SCRUB FL BLUECURLS, HIDDEN LAKE CA BLUEGRASS, HIAN HI BLUEGRASS, MANN'S ( POA MANNII) HI BLUEGRASS, NAPA CA BLUEGRASS, SAN BERNARDINO CA BLUE STAR, KEARNEY'S AZ BLUET, ROAN MOUNTAIN NC, TN BONAMIA MENZIESII ( NCN) HI BONAMIA, FL FL BRODIAEA, CHINESE CAMP CA BRODIAEA, THREAD LEAVED CA BROOM, SAN CLEMENTE ISLAND CA BUCKWHEAT, CUSHENBURY CA BUCKWHEAT, IONE ( IRISH HILL) CA BUCKWHEAT, SCRUB FL BUCKWHEAT, SOUTHERN MOUNTAIN WILD CA BULRUSH, NORTHEASTERN (= BARBED BRISTLE) MD, MA, PA, VT, VA, WV BUSH CLOVER, PRAIRIE IL, IA, MN, WI BUSH MALLOW, SAN CLEMENTE ISLAND CA BUSHMALLOW, SANTA CRUZ ISLAND CA BUTTERCUP, AUTUMN UT BUTTERFLY PLANT, CO CO BUTTERWEED, LAYNE'S CA BUTTERWORT, GODFREY'S FL BUTTON CELERY, SAN DIEGO CA CACTUS, AZ HEDGEHOG AZ CACTUS, BAKERSFIELD CA CACTUS, BLACK LACE TX CACTUS, BRADY PINCUSHION AZ CACTUS, COCHISE PINCUSHION AZ CACTUS, KNOWLTON CO, NM CACTUS, KUENZLER HEDGEHOG NM CACTUS, LEE PINCUSHION NM CACTUS, MESA VERDE CO, NM G 8 CACTUS, NICHOL'S TURK'S HEAD AZ CACTUS, PEEBLES NAVAJO AZ CACTUS, PIMA PINEAPPLE AZ CACTUS, SAN RAFAEL UT CACTUS, SILER PINCUSHION AZ, UT CACTUS, SNEED PINCUSHION NM, TX CACTUS, STAR TX CACTUS, TOBUSCH FISHHOOK TX CACTUS, UINTA BASIN HOOKLESS CO, UT CACTUS, WINKLER UT CACTUS, WRIGHT FISHHOOK UT CAMPION, FRINGED FL, GA CATCHFLY, SPALDING'S ID. MT, OR, WA CEANOTHUS, COYOTE CA CEANOTHUS, PINE HILL CA CEANOTHUS, VAIL LAKE CA CENTAURY, SPRING LOVING CA, NV CHAFFSEED, AMERICAN FL, NJ, NC, SC CHAMAESYCE HALEMANUI HI CHECKER MALLOW, KECK'S CA CHECKER MALLOW, KENWOOD MARSH CA CHECKER MALLOW, NELSON'S OR, WA CHECKER MALLOW, PEDATE CA CHECKER MALLOW, WENATCHEE MOUNTAINS WA CLADONIA, FL PERFORATE FL CLARKIA, PISMO CA CLARKIA, PRESIDIO CA CLARKIA, SPRINGVILLE CA CLARKIA, VINE HILL CA CLIFFROSE, AZ AZ CLOVER, MONTEREY CA CLOVER, RUNNING BUFFALO IN, KY, MO, OH, WV CLOVER, SHOWY INDIAN CA CONEFLOWER, SMOOTH NC, SC, VA CONEFLOWER, TN PURPLE TN COYOTE THISTLE, LOCH LOMOND CA CROWN BEARD, BIG LEAVED CA CROWNSCALE, SAN JACINTO VALLEY CA CYANEA UNDULATA ( NCN) HI CYCLADENIA, JONES AZ, UT CYPRESS, GOWEN CA CYPRESS, SANTA CRUZ CA DAISY, LAKESIDE IL, OH DAISY, MAGUIRE UT DAISY, PARISH'S CA DAISY, WILLAMETTE OR DAWN FLOWER, TX PRAIRIE (= TX BITTERWEED TX DELISSEA RHYTODISPERMA ( NCN) HI DIELLIA ERECTA ( NCN) HI DIELLIA PALLIDA ( NCN) HI DOCK, CHIRICAHUA AZ, NM G 9 DOGWEED, ASHY TX DROPWORT, CANBY'S GA, MD, NC, SC DUBAUTIA LATIFOLIA HI DUBAUTIA PAUCIFLORULA HI DUDLEYA, CONEJO CA DUDLEYA, MARCESCENT CA DUDLEYA, SANTA CLARA VALLEY CA DUDLEYA, SANTA CRUZ ISLAND CA DUDLEYA, SANTA MONICA MOUNTAINS CA DUDLEYA, VERITY'S CA DWARF FLAX, MARIN CA EVENING PRIMROSE, ANTIOCH DUNES CA EVENING PRIMROSE, EUREKA VALLEY CA EVENING PRIMROSE, SAN BENITO CA FERN, AL STREAK SORUS AL FERN, AMERICAN HART'S TONGUE AL, MI, NY, TN FERN, PENDANT KIHI ( ADENOPHORUS PERIENS) HI FIDDLENECK, LARGE FLOWERED CA FLANNELBUSH, MEXICAN CA FLANNELBUSH, PINE HILL CA FLEABANE, ZUNI AZ, NM FOUR O'CLOCK, MACFARLANE'S ID, OR FRINGE TREE, PYGMY FL FRINGEPOD, SANTA CRUZ ISLAND CA FRITILLARY, GENTNER'S OR GEOCARPON MINIMUM AR, LA,, MO GERARDIA, SANDPLAIN CT, MD, MA, NY, RI GILIA, HOFFMANN'S SLENDER FLOWERED CA GILIA, MONTEREY CA GOLDEN SUNBURST, HARTWEG'S CA GOLDENROD, BLUE RIDGE NC GOLDENROD, BLUE RIDGE TN GOLDENROD, HOUGHTON'S MI GOLDENROD, SHORT'S KY GOLDENROD, WHITE HAIRED KY GOLDFIELDS, BURKE'S CA GOLDFIELDS, CONTRA COSTA CA GOOSEBERRY, MICCOSUKEE ( FL) FL GOUANIA MEYENII ( NCN) HI GOURD, OKEECHOBEE FL GRASS, CA ORCUTT CA GRASS, COLUSA CA GRASS, EUREKA DUNE CA GRASS, HAIRY ORCUTT CA GRASS, SACRAMENTO ORCUTT CA GRASS, SAN JOAQUIN VALLEY ORCUTT CA GRASS, SLENDER ORCUTT CA GRASS, SOLANO CA GRASS, TN YELLOW EYED AL, GA, TN GROUND PLUM, GUTHRIE'S TN GROUNDSEL, SAN FRANCISCO PEAKS AZ G 10 GUMPLANT, ASH MEADOWS CA, NV HAHA ( CYANEA ASARIFOLIA) HI HAHA ( CYANEA COPELANDII SSP. COPELANDII) HI HAHA ( CYANEA HAMATIFLORA SSP. CARLSONII) HI HAHA ( CYANEA PLATYPHYLLA) HI HAHA ( CYANEA RECTA) HI HAHA ( CYANEA REMYI) HI HAHA ( CYANEA SHIPMANII) HI HAHA ( CYANEA STICTOPHYLLA) HI HA'IWALE ( CYRTANDRA GIFFARDII) HI HA'IWALE ( CYRTANDRA LIMAHULIENSIS) HI HALA PEPE ( PLEOMELE HIENSIS) HI HAPLOSTACHYS HAPLOSTACHYA ( NCN) HI HAREBELLS, AVON PARK FL HARPERELLA AL, AR, MD, NC, SC, WV HAU KAUHIWI ( HIBISCADELPHUS WOODI) HI HAU KUAHIWI ( HIBISCADELPHUS DISTANS) HI HEARTLEAF, DWARF FLOWERED NC, SC HEATHER, MOUNTAIN GOLDEN NC HEAU ( EXOCARPOS LUTEOLUS) HI HEDYOTIS ST. JOHNII ( NCN) HI HESPEROMANNIA LYDGATEI ( NCN) HI HIBISCUS, CLAY'S HI HILO ISCHAEMUM ( ISCHAEMUM BYRONE) HI HOLEI ( OCHROSIA KILAUEAENSIS) HI HOWELLIA, WATER ID, MT, WA HYPERICUM, HIGHLANDS SCRUB FL ILIAU ( WILKESIA HOBDYI) HI IPOMOPSIS, HOLY GHOST NM IRIS, DWARF LAKE MI, WI IRISETTE, WHITE NC, SC IVESIA, ASH MEADOWS CA IVESIA, ASH MEADOWS NV JACQUEMONTIA, BEACH FL JEWELFLOWER, CA CA JEWELFLOWER, TIBURON CA JOINT VETCH, SENSITIVE MD, NJ, NC, VA KAMAKAHALA ( LABORDIA LYDGATEI) HI KAMAKAHALA ( LABORDIA TINIFOLIA VAR. WAHIAWAEN HI KAUILA ( COLUBRINA OPPOSITIFOLIA) HI KAULU ( PTERALYXIA KAUAIENSIS) HI KIO'ELE ( HEDYOTIS CORIACEA) HI KIPONAPONA ( PHYLLOSTEGIA RACEMOSA) HI KOKI'O ( KOKIA DRYNARIOIDES) HI KOKI'O ( KOKIA KAUAIENSIS) HI KOKI'O KE'OKE'O ( HIBISCUS WAIMEAE SSP. HANNER HI KOLEA ( MYRSINE LINEARIFOLIA) HI KO'OLOA'ULA ( ABUTILON MENZIESII) HI KUAWAWAENOHU ( ALSINIDENDRON LYCHNOIDES) HI G 11 LADIES' TRESSES, CANELO HILLS AZ LADIES' TRESSES, NAVASOTA TX LADIES' TRESSES, UTE CO, NV, UT LARKSPUR, BAKER'S CA LARKSPUR, SAN CLEMENTE ISLAND CA LARKSPUR, YELLOW CA LAU'EHU ( PANICUM NIIHAUENSE) HI LAUKAHI KUAHIWI ( PLANTAGO HAWAIENSIS) HI LAUKAHI KUAHIWI ( PLANTAGO PRINCEPS) HI LAULIHILIHI ( SCHIEDEA STELLARIOIDES) HI LAYIA, BEACH CA LEAD PLANT, CRENULATE FL LEATHER FLOWER, AL AL LEATHER FLOWER, MOREFIELD'S AL LESSINGIA, SAN FRANCISCO CA LICHEN, ROCK GNOME NC, TN LILY, MN TROUT MN LILY, PITKIN MARSH CA LILY, WESTERN CA, OR LIPOCHAETA VENOSA ( NCN) HI LIVEFOREVER, LAGUNA BEACH CA LIVEFOREVER, SANTA BARBARA ISLAND CA LOBELIA NIIHAUENSIS ( NCN) HI LOCOWEED, FASSETT'S WI LOMATIUM, BRADSHAW'S OR LOMATIUM, COOK'S OR LOOSESTRIFE, ROUGH LEAVED NC, SC LOULU ( PRITCHARDIA AFFINIS) HI LOULU ( PRITCHARDIA NAPALIENSIS) HI LOULU ( PRITCHARDIA SCHATTAUERI) HI LOULU ( PRITCHARDIA VISCOSA) HI LOUSEWORT, FURBISH ME LUPINE, CLOVER CA LUPINE, KINCAID'S OR, WA LUPINE, NIPOMO MESA CA LUPINE, SCRUB FL LYSIMACHIA FILIFOLIA ( NCN) HI MAHOE ( ALECTRYON MACROCOCCUS) HI MAKOU ( PEUCEDANUM SANDWICENSE) HI MALACOTHRIX, ISLAND CA MALACOTHRIX, SANTA CRUZ ISLAND CA MALLOW, KERN CA MALLOW, PETER'S MOUNTAIN VA MANIOC, WALKER'S TX MANZANITA, DEL MAR CA MANZANITA, IONE CA MANZANITA, MORRO CA MANZANITA, PALLID CA MANZANITA, SAN BRUNO MOUNTAIN CA MANZANITA, SANTA ROSA ISLAND CA MA'O HAU HELE ( HIBISCUS BRACKENRIDGEI) HI G 12 MA'OLI'OLI ( SCHIEDEA APOKREMNOS) HI MAPELE ( CYRTANDRA CYANEOIDES) HI MARISCUS FAURIEI ( NCN) HI MARISCUS PENNATIFORMIS ( NCN) HI MEADOWFOAM, BUTTE COUNTY CA MEADOWFOAM, LARGE FLOWERED WOOLY OR MEADOWFOAM, SEBASTOPOL CA MEADOWRUE, COOLEY'S FL, NC MEHAMEHAME ( FLUEGGEA NEOWAWRAEA) HI MILKPEA, SMALL'S FL MILK VETCH, APPLEGATE'S OR MILK VETCH, ASH MEADOWS NV MILK VETCH, BRAUNTON'S CA MILK VETCH, CLARA HUNT'S CA MILK VETCH, COACHELLA VALLEY CA MILK VETCH, COASTAL DUNES CA MILK VETCH, CUSHENBURY CA MILK VETCH, DESERET UT MILK VETCH, FISH SLOUGH CA MILK VETCH, HELIOTROPE UT MILK VETCH, HOLMGREN AZ, UT MILK VETCH, JESUP'S NH, VT MILK VETCH, LANE MOUNTAIN CA MILK VETCH, MANCOS CO, NM MILK VETCH, PIERSON'S CA MILK VETCH, SENTRY AZ MILK VETCH, SHIVWITS UT MILK VETCH, TRIPLE RIBBED CA MILK VETCH, VENTURA MARSH CA MILKWEED, MEAD'S IL, IA, KS, MO MILKWEED, WELSH'S AZ. UT MINT, GARRETT'S FL MINT, LAKELA'S FL MINT, LONGSPURRED FL MINT, OTAY MESA CA MINT, SAN DIEGO MESA CA MINT, SCRUB FL MONARDELLA, WILLOWY CA MONKEY FLOWER, MI MI MONKSHOOD, NORTHERN WILD IA, NY, OH, WI MORNING GLORY, STEBBINS CA MOUNTAINBALM, INDIAN KNOB CA MOUNTAIN MAHOGANY, CATALINA ISLAND CA MUNROIDENDRON RACEMOSUM ( NCN) HI MUSTARD, CARTER'S FL MUSTARD, SLENDER PETALED CA NANI WAI'ALE'ALE ( VIOLA KAUAENSIS VAR. WAHIAW HI NAVARRETIA, FEW FLOWERED CA NAVARRETIA, MANY FLOWERED CA NAVARRETIA, SPREADING CA G 13 NEHE ( LIPOCHAETA FAURIEI) HI NEHE ( LIPOCHAETA MICRANTHA) HI NEHE ( LIPOCHAETA WAIMEAENSIS) HI NERAUDIA OVATA ( NCN) HI NERAUDIA SERICEA ( NCN) HI NITERWORT, AMARGOSA CA NITERWORT, AMARGOSA NV NOHOANU ( GERANIUM MULTIFLORUM) HI ' OHA ( DELISSEA RIVULARIS) HI ' OHA ( DELISSEA UNDULATA) HI ' OHA WAI ( CLERMONTIA DREPANOMORPHA) HI ' OHA WAI ( CLERMONTIA LINDSEYANA) HI ' OHA WAI ( CLERMONTIA PELEANA) HI ' OHA WAI ( CLERMONTIA PYRULARIA) HI ' OHAI ( SESBANIA TOMENTOSA) HI ' OLULU ( BRIGHAMIA INSIGNIS) HI ONION, MUNZ'S CA ORCHID, EASTERN PRAIRIE FRINGED IL, IA, ME, MI, OH, OK, VA, WI OWL'S CLOVER, FLESHY CA OXYTHECA, CUSHENBURY CA PAINTBRUSH, ASH GREY INDIAN CA PAINTBRUSH, GOLDEN WA PAINTBRUSH, SAN CLEMENTE ISLAND INDIAN CA PAINTBRUSH, SOFT LEAVED CA PAINTBRUSH, TIBURON CA PAWPAW, BEAUTIFUL FL PAWPAW, FOUR PETAL FL PAWPAW, RUGEL'S FL PENNY CRESS, KNEELAND PRAIRIE CA PENNYROYAL, TODSEN'S NM PENSTEMON, BLOWOUT NE PENTACHAETA, LYON'S CA PENTACHAETA, WHITE RAYED CA PEPPER GRASS, KODACHROME UT PEPPERGRASS, SLICK SPOT ID PHACELIA, CLAY UT PHACELIA, ISLAND CA PHLOX, TX TRAILING TX PHLOX, YREKA CA PHYLLOSTEGIA KNUDSENII ( NCN) HI PHYLLOSTEGIA VELUTINA ( NCN) HI PHYLLOSTEGIA WAIMEAE ( NCN) HI PHYLLOSTEGIA WARSHAUERI ( NCN) HI PHYLLOSTEGIA WAWRANA ( NCN) HI PINK, SWAMP DE, GA, MD, NJ, NC, SC, VA PINKROOT, GENTIAN FL PIPERIA, YADON'S CA PITCHER PLANT, AL CANEBRAKE AL PITCHER PLANT, GREEN AL, GA, NC PITCHER PLANT, MOUNTAIN SWEET NC, SC PLATANTHERA HOLOCHILA ( NCN) HI G 14 PLUM, SCRUB FL POA SIPHONOGLOSSA ( NCN) HI PO'E ( PORTULACA SCLEROCARPA) HI POGONIA, SMALL WHORLED CT, DE, GA, IL, ME, MA, MI, NH, NJ, NY, NC,

PA, RI, SC, TN, VA POLYGALA, LEWTON'S FL POLYGALA, TINY FL POLYGONUM, SCOTT'S VALLEY CA PONDBERRY AR, GA, MS, MO, NC, SC PONDWEED, LITTLE AGUJA CREEK TX POPCORNFLOWER, ROUGH OR POPOLO ' AIAKEAKUA ( SOLANUM SANDWICENSE) HI POPOLO KU MAI ( SOLANUM INCOMPLETUM) HI POPPY, SACRAMENTO PRICKLY NM POPPY MALLOW, TX TX POTATO BEAN, PRICE'S AL, IL, KY, NC, TN POTENTILLA, HICKMAN'S CA PRAIRIE CLOVER, LEAFY AL, IL, TN PRICKLY APPLE, FRAGRANT FL PRIMROSE, MAGUIRE UT PUSSYPAWS, MARIPOSA CA PU'UKA'A ( CYPERUS TRACHYSANTHOS) HI QUILLWORT, BLACK SPORED GA, SC QUILLWORT, LOUISIANA AL, LA QUILLWORT, MAT FORMING GA RATTLEWEED, HAIRY GA REED MUSTARD, BARNEBY UT REED MUSTARD, CLAY UT REED MUSTARD, SHRUBBY UT REMYA KAUAIENSIS ( NCN) HI REMYA MONTGOMERYI ( NCN) HI RHODODENDRON, CHAPMAN FL RIDGE CRESS (= PEPPER CRESS), BARNEBY UT ROCK CRESS, HOFFMANN'S CA ROCK CRESS, LARGE (= BRAUN'S) KY, TN ROCK CRESS, MCDONALD'S CA ROCK CRESS, SANTA CRUZ ISLAND CA ROCK CRESS, SHALE BARREN VA, WV ROCK CRESS, SMALL KY ROSEMARY, CUMBERLAND KY, TN ROSEMARY, ETONIA FL ROSEMARY, SHORT LEAVED FL ROSEROOT, LEEDY'S MN, NY RUSH PEA, SLENDER TX RUSH ROSE, ISLAND CA SANDLACE FL SAND VERBENA, LARGE FRUITED TX SANDWORT, BEAR VALLEY CA SANDWORT, CUMBERLAND KY, TN SANDWORT, MARSH CA SCHIEDEA HELLERI ( NCN) HI G 15 SCHIEDEA KAUAIENSIS ( NCN) HI SCHIEDEA MEMBRANACEA ( NCN) HI SCHIEDEA NUTTALLII ( NCN) HI SCHIEDEA SPERGULINA VAR. LEIOPODA ( NCN) HI SCHIEDEA SPERGULINA VAR. SPERGULINA ( NCN) HI SEA BLITE, CA CA SEAGRASS, JOHNSON'S FL SEDGE, GOLDEN NC SEDGE, NAVAJO AZ, UT SEDGE, WHITE CA SILENE HIENSIS ( NCN) HI SILENE LANCEOLATA ( NCN) HI SILVERSWORD, KA'U ( ARGYROXIPHIUM KAUENSE) HI SILVERSWORD, MAUNA KEA (' AHINAHINA) HI SKULLCAP, LARGE FLOWERED GA, TN SNAKEROOT FL SNEEZEWEED, VA MO, VA SNOWBELLS, TX TX SPERMOLEPIS HIENSIS ( NCN) HI SPIDERLING, MATHIS TX SPINEFLOWER, BEN LOMOND CA SPINEFLOWER, HOWELL'S CA SPINEFLOWER, MONTEREY CA SPINEFLOWER, ORCUTT'S CA SPINEFLOWER, ROBUST CA SPINEFLOWER, SCOTTS VALLEY CA SPINEFLOWER, SLENDER HORNED CA SPINEFLOWER, SONOMA CA SPIRAEA, VA GA, KY, NC, TN, VA, WV SPURGE, DELTOID FL SPURGE, GARBER'S FL SPURGE, HOOVER'S CA SPURGE, TELEPHUS FL STENOGYNE ANGUSTIFOLIA ( NCN) HI STENOGYNE CAMPANULATA ( NCN) HI STICKSEED, SHOWY WA STICKYSEED, BAKER'S CA STONECROP, LAKE COUNTY CA SUMAC, MICHAUX'S GA, NC, VA SUNFLOWER, EGGERT'S AL, KY, TN SUNFLOWER, PECOS NM, TX SUNFLOWER, SAN MATEO WOOLLY CA SUNFLOWER, SCHWEINITZ'S NC, SC SUNRAY, ASH MEADOWS NV TARAXACUM, CA CA TARPLANT, GAVIOTA CA TARPLANT, OTAY CA TARPLANT, SANTA CRUZ CA TETRAMOLOPIUM ARENARIUM ( NCN) HI THELYPODY, HOWELL'S SPECTACULAR OR THISTLE, CHORRO CREEK BOG CA G 16 THISTLE, FOUNTAIN CA THISTLE, LA GRACIOSA CA THISTLE, PITCHER'S IN, MI, WI THISTLE, SACRAMENTO MOUNTAINS NM THISTLE, SUISUN CA THORNMINT, SAN DIEGO CA THORNMINT, SAN MATEO CA TORREYA, FL FL. GA TOWNSENDIA, LAST CHANCE UT TRILLIUM, PERSISTENT GA, SC TRILLIUM, RELICT AL, GA, SC TUCTORIA, GREEN'S CA UHIUHI ( CAESALPINIA KAVAIENSIS) HI UMBEL, HUACHUCA WATER AZ VERVAIN, CA CA VETCH, HIAN ( VICIA MENZIESII) HI VIGNA O WAHUENSIS ( NCN) HI VIOLA HELENAE ( NCN) HI WAHINE NOHO KULA ( ISODENDRION PYRIFOLIUM) HI WALLFLOWER, BEN LOMOND CA WALLFLOWER, CONTRA COSTA CA WALLFLOWER, MENZIE'S CA WAREA, WIDE LEAF FL WATERCRESS, GAMBEL'S CA WATER PLANTAIN, KRAL'S AL, GA WATER WILLOW, COOLEY'S FL WAWAE'IOLE ( PHLEGMARIURUS (= HUPERZIA) MANNII) HI WAWAE'IOLE ( PHLEGMARIURUS (= LYCOPODIUM) NUTAN HI WHITLOW WORT, PAPERY FL WILD BUCKWHEAT, CLAY LOVING CO WILD BUCKWHEAT, GYPSUM NM WILD RICE, TX TX WINGS, PIGEON FL WIRE LETTUCE, MALHEUR OR WIREWEED FL WOODLAND STAR, SAN CLEMENTE ISLAND CA WOOLLY STAR, SANTA ANA RIVER CA WOOLLY THREADS, SAN JOAQUIN CA XYLOSMA CRENATUM ( NCN) HI YERBA SANTA, LOMPOC CA ZIZIPHUS, FL FL G 17 Table G 3. List of endangered mammalian species potentially at risk from napropamide use SPECIES NAME STATE( S)

BAT, GRAY AL, AR, FL, GA, IL, IN, KS, KY, MO, OK,

TN, VA, WV BAT, HIAN HOARY HI BAT, INDIANA AL, AR, CT, FL, GA, IL, IN, IA, KY, MD, MA,

MI, MO, NH, NJ, NY, NC, OH, OK, PA, RI,

TN, VT, VA, WV BAT, LESSER (= SANBORN'S) LONG NOSED AZ, NM BAT, MEXICAN LONG NOSED NM BAT, OZARK BIG EARED AR, OK BAT, VA BIG EARED GA, KY, NC, VA, WV BEAR, AMERICAN BLACK LA BEAR, GRIZZLY ID, MT, WA, WY BEAR, LA BLACK LA, MS, TX CARIBOU, WOODLAND ID DEER, COLUMBIAN WHITE TAILED OR, WA FERRET, BLACK FOOTED CO, KS, MT, NE, NM, SD, UT, WY FOX, SAN JOAQUIN KIT CA FOX, SAN MIGUEL ISLAND CA FOX, SANTA CATALINA ISLAND CA FOX, SANTA CRUZ ISLAND CA FOX, SANTA ROSA ISLAND CA JAGUAR AZ, NM JAGUARUNDI, Gulf Coast TX Jaguarundi, Sinaloan AZ KANGAROO RAT, FRESNO CA KANGAROO RAT, GIANT CA KANGAROO RAT, MORRO BAY CA KANGAROO RAT, SAN BERNARDINO CA KANGAROO RAT, STEPHENS' CA KANGAROO RAT, TIPTON CA LYNX, CANADA ME MANATEE, WEST INDIAN ( FL) FL, GA MOUNTAIN BEAVER, POINT ARENA CA MOUSE, AL BEACH AL MOUSE, ANASTASIA ISLAND BEACH FL MOUSE, CHOCTAWHATCHEE BEACH FL MOUSE, PACIFIC POCKET CA MOUSE, PERDIDO KEY BEACH AL, FL MOUSE, PREBLE'S MEADOW JUMPING CO MOUSE, SALT MARSH HARVEST CA MOUSE, SOUTHEASTERN BEACH FL OCELOT AZ, TX OTTER, SOUTHERN SEA CA PANTHER, FL FL PRAIRIE DOG, UT UT PRONGHORN, SONORAN AZ RABBIT, PYGMY WA RABBIT, RIPARIAN BRUSH CA G 18 SEAL, GUADALUPE FUR CA SEAL, HIAN MONK HI SHEEP, PENINSULAR BIGHORN CA SHEEP, SIERRA NEVADA BIGHORN CA SHREW, BUENA VISTA CA SQUIRREL, CAROLINA NORTHERN FLYING NC, TN, WV SQUIRREL, DELMARVA PENINSULA FOX DE, MD, PA, VA SQUIRREL, MOUNT GRAHAM RED AZ SQUIRREL, NORTHERN ID GROUND ID SQUIRREL, VA NORTHERN FLYING VA, WV VOLE, AMARGOSA CA VOLE, FL SALT MARSH FL VOLE, HUALAPAI MEXICAN AZ WHALE, NORTHERN RIGHT CT, DE, FL, ME, MD, MA, NJ, NY, NC, RI, SC, VA WOLF, GRAY AZ, ID, MI, MN, MT, NM, WA, WI, WY WOLF, RED NC, SC, TN WOODRAT, RIPARIAN CA H 1 APPENDIX H. EXPLANATION OF LEVEL OF CONCERN ( LOC) AND PROBIT SLOPE Use of the Probit Dose Response Relationship to Provide Information on the Endangered Species Levels of Concern Introduction The document entitled Overview of Ecological Risk Assessment Process in the Office of Pesticide Programs, U. S. Environmental Protection Agency ( USEPA 2004, the Overview Document) discusses methods for providing the U. S. Fish and Wildlife Service ( USFWS) and the National Marine Fisheries Service ( NMFS) with additional information regarding the listed animal species acute levels of concern ( LOCs). This document provides ( 1) the background information on how agreements were reached between the services and USEPA for methods to provide additional LOC information, and ( 2) a discussion of issues concerning those methods and their resolution. Risk Assessors within the Environmental Fate and Effects Division ( EFED) should use the Overview Document as well as the following information as guidance for using the probit dose response relationship as a tool for providing additional information on the listed species LOCs Effective immediately, all screening level risk assessments ( REDS, Section 3' s, Section 18' s, etc.) using risk quotient ( RQ) methods will incorporate this analysis, regardless of whether listed species LOCs are exceeded or not.

Background on Discussion of LOCs with USFWS and NMFS Over the course of negotiations with the USFWS and NMFS, one topic of discussion centered on the risk quotient values established as screening thresholds for consideration of direct toxic effects on listed species ( i. e., the acute listed species LOCs of 0.1 and 0.05 used for terrestrial and aquatic animals, respectively). The Agency provided the Services with the mathematical interpretations of these LOC values, which was documented in the background information supplied to the Services and is included in the Overview Document CD distributed to all employees in EFED. In short, the interpretation of the LOCs was discussed in terms of best estimates of the chance of an individual event ( mortality or immobilization) should exposure at the estimated environmental concentration actually occur for a species with sensitivity to the pesticide on par with the toxicity endpoint selected for RQ calculation.

The mathematics were based on a long held assumption of a probit dose response relationship for acute toxicity endpoints. The listed species LOCs or the fraction ( 0.05 or 0.1) of the dose estimated to produce 50% mortality were used to interpolate from a probit dose response curve to estimate the associated ECx, LDx, or LCx. These values were then used to estimate the chance of an individual event.

Two issues were identified over the course of discussions with the Services in regard to the Agency's presentations of the math and the interpretation of the LOCs. First was the issue that the chance of individual event was highly dependant upon the assumed shape and slope of the H 2 dose response relationship. Second was that the Services were unwilling to present a generic threshold of the chance of an individual event, below which the Services would not have a concern for listed species impacts The services indicated that the baseline conditions of a species and it's biology would dictate species specific concerns for tolerated effects. Further discussion on the confidence of extreme value extrapolations for probit dose response did not achieve an agreement between all parties on what the lower limit of cutoff in reporting extreme events should be for interpretation of listed species acute LOCs. Even consideration of using the most intolerant listed species within taxonomic groups as a screening basis for other more tolerant listed species was not accepted as a viable strategy for establishing generic effects thresholds for listed species.

Consequently, it was accepted by all parties that the Agency would provide in its risk assessments an interpretation of the listed species LOCs in terms of the chance of an individual effect should organisms be exposed to a media concentration or dose corresponding to 1/ 10 or 1/ 20 of the LC 50 , LD 50 , or EC 50 used as the acute toxicity measurement endpoint for a particular animal taxonomic group. To accomplish this interpretation, the Agency would use ( 1) the slope of the dose response relationship available from the toxicity study used to establish the acute toxicity measurement endpoints for each animal taxonomic group; ( 2) an assumption of a probit dose response relationship; ( 3) a mean estimate of slope consistent with current Agency statistical procedures; and ( 4) a lower limit to the estimate of individual effect chance based on what could be calculated by Excel spreadsheet " Normdist" function.

Issues with the LOC Interpretation Method and Their Resolution Discussion within the Agency has identified three issues with regard to the calculation of the chance of individual event corresponding to the listed species acute LOCs. The largest issue is the extrapolation to extremely low probability events, referring to the very large confidence intervals surrounding such estimates. A secondary issue, but still very important, is the extent to which probit dose response slopes can be calculated for existing studies ( i. e., the fitting of a probit dose response relationship to available data). The third issue is how to proceed when information is unavailable to estimate a slope. The following guidance information will address these issues:

Extrapolation to Extremely Low Probability Events The nature of this issue centers on the fact that slope estimates are accompanied by a corresponding variance in the slope term. This variance in the slope term and to some extent the variance in the median lethal dose estimate, can result in wide variations of effects probabilities at the upper and lower tails of the dose range. While the Agency has agreed to present the effects probability associated with the LOCs based on the mean estimate of slope, it is evident that expression of this single estimate of the corresponding effects probability would suggest that the Agency has inordinately high confidence in this estimate, when in fact there is likely considerable variability in the estimate. Consequently, for the short term, it is recommended that both the estimate of effects probability be calculated for the mean slope estimate and listed species LOC and available information on the 95% confidence interval of the slope estimate be used to calculate an upper and lower estimate of the effects probability. It is important to note that interpretation of these results is not required under agreement with the Services. The Services H 3 have requested that the results be made available in the screening assessment reports. It is recommended that reporting minimally include the following discussion:

" Based on an assumption of a probit dose response relationship with a mean estimated slope of ( enter slope here), the corresponding estimated chance of individual mortality associated with the listed species LOC of ( 0.1 or 0.05) the acute toxic endpoint for ( enter appropriate animal taxonomic group) is ( enter value). It is recognized that extrapolation of very low probability events is associated with considerable uncertainty in the resulting estimates. To explore possible bounds to such estimates, the upper and lower values for the mean slope estimate ( enter the 95 percent confidence interval for the slope) were used to calculate upper and lower estimates of the effects probability associated with the listed species LOC. These values are ( enter the upper and lower estimates)."

For the present time, the Excel spreadsheet tool IECV1.1 will allow for such calculations by entering in the mean slope estimate and the 95 percent confidence bounds of that estimate as the slope parameter for the spreadsheet. It is important to note that the model output can go as low as 10 E 16 in estimating the event probability. This cut off is a limit in the Excel spreadsheet environment and is not to be interpreted as an agreed upon lower bound threshold for concern for individual effects in any given listed species.

EFED will continue to work on establishing subsequent approaches to account for both the variance in the slope and the median lethal dose estimate when establishing this upper and lower estimates of effects estimates associated with the listed species LOCs.

Probit Slopes for Existing Studies Slope information may or may not be estimated for a given study upon which RQs were calculated. When the available data evaluation records ( DERs) or study reports provide the slope information ( i. e., mean slope estimate, p value of estimate, and 95% confidence interval of the estimate) , it should be used as reported once these reported values have been carefully reviewed to ensure their accuracy. However, there are likely to be situations where slope information is not provided in the DERs. For such situations, the raw data from the study must be entered into and analyzed by the EFED current statistical package for acute effects studies. See the EFED Statistical Workgroup for assistance with accessing these software. Probit slope information will be used from these analyses. However, there a re two distinctions that must be made in the reporting of these results for listed species evaluation. First, studies with good probit fit characteristics can be used as reported accompanied with a statement that the probit dose response relationship was statistically appropriate for the data set. Alternatively, if the assumption of a probit dose response was shown to be statistically unsupported, the slope estimates are still used in the listed species LOC interpretation ( remember we have in our policy assumed probit dose response when LOCs were established), but the statistical rejection criteria must be presented along with a statement :

" Although the Agency has assumed a probit dose response relationship in establishing the listed species LOCs, the available data for the toxicity study H 4 generating RQs for this taxonomic group do not statistically support a probit dose response relationship ( enter the p value from the statistical package) and so the confidence in estimated event probabilities based on this dose response relationship and the listed species LOC is low."

EFED will continue to work on the development of statistical tools to explore alternative dose response relationships in situations where the assumption of probit dose response relationship is not upheld by available data.

How to Proceed When Information is Unavailable to Estimate a Slope State in the assessment that information is unavailable to estimate a slope from the available toxicity study and the reason why re analysis of raw data is not possible. Then state that a event probability was calculated for the listed species LOC based on a default slope assumption of 4.5 as per original Agency assumptions of typical slope cited in Urban and Cook ( 1986).

References United States Environmental Protection Agency ( USEPA). 2004. Overview of Ecological Risk Assessment Process in the Office of Pesticide Programs, U. S. Environmental Protection Agency. Office of Prevention, Pesticides and Toxic Substances, Office of Pesticide Programs, Washington, DC.

Urban D. J. and N. J. Cook. 1986. Hazard Evaluation Division Standard Evaluation Procedure Ecological Risk Assessment. EPA 540/ 9 85 001. U. S. Environmental Protection Agency, Office of Pesticide Programs, Washington, DC.