leaves [Bassica (Cole) Leafy Vegetable Crop Group] and grapes stored
frozen at <-18(C for 30 months. Adequate stability data are available on
cabbage and grapes to support the storage conditions and intervals of
samples from the leaf lettuce field trials.

The maximum residue of fluopicolide was 11.7 ppm in/on leaf lettuce
harvested 2 days after the last of three foliar applications of the 40%
SC formulation (EXP 11067B) at a total rate of 0.349 to 0.364 lb a.i./A.
 The maximum residue of BAM was 0.038 ppm.  Residues of PCA were less
than the limit of quantitation (0.01 ppm) in/on all leaf lettuce
samples.  Residue decline data show that fluopicolide (parent) residues
generally decrease with increasing preharvest intervals.

Spinach:  Valent U.S.A. Corporation has submitted field trial data for
fluopicolide on spinach.  Seven field trials (six harvest and one
decline) were conducted in the United States encompassing Zones 1 (1
trial in New Jersey), 2 (1 trial in Virginia), 6 (2 trials in Texas), 9
(1 trial in Colorado), and 10 (1 trial in Arizona and 1 trial in
California) during the 2002 growing season.  At each test location,
there was one untreated and one treated plot. The treated plots received
three broadcast foliar applications of fluopicolid, formulated as a 4 lb
ai/gal suspension concentrate, at 5 ± 1 day retreatment intervals.
Each application was performed at a nominal application rate of 0.119 lb
ai/A, for a total seasonal application rate of 0.357 to 0.365 lb
ai/A/season (~1x the proposed rate). A spreader/sticker was added to the
spray mixture for all applications. At each trial location, one
untreated control and two treated spinach raw agricultural commodity
(RAC) samples were collected 2 days following the last test substance
application [2-day preharvest interval (PHI)]. In addition, at the
Virginia test site, one control and duplicate treated spinach samples
were also harvested at 1, 3, 5, and 7 days after the last application to
determine residue decline.

Spinach samples were analyzed for residues of fluopicolide (parent) and
its metabolites BAM (AE C653711) and PCA (AE C657188) via high pressure
liquid chromatography/triple stage quadropole mass spectrometry
(HPLC/MS/MS) detection, method METH1611-00.02. The method was adequate
for data collection based on acceptable method validation and concurrent
method recoveries. The LOQ was 0.01 ppm for each analyte in spinach.

Samples were stored frozen (<- 20oC) prior to analysis for a maximum of
1169 days (38 months) from harvest to analysis.  Storage stability on
spinach are not available.  Residues of fluopicolide, BAM, and PCA are
stable in/on cabbage leaves [Brassica (Cole) Leafy Vegetable Crop Group]
and grapes stored frozen at ≤-18 (C for 30 months.  The storage
interval in the cabbage/grape storage stability study was approximately
8 months less than the maximum storage interval in the spinach crop
field trial study.

The maximum residue of fluopicolide   SEQ CHAPTER \h \r 1 was 16.8 ppm
in/on spinach harvested 2 days after the last of three foliar
applications of the 40% SC formulation (EXP 11067B) at a total rate of
0.357 to 0.365 lb a.i./A.  The maximum residues of BAM and PCA were
0.188 ppm and 0.119 ppm (after 3 days), respectively.  Residue decline
data showed that parent fluopicolide residues generally decrease with
increasing preharvest intervals, BAM residues remain relatively constant
with increasing preharvest intervals, and PCA residues generally
increase with increasing preharvest intervals.

Conclusions:  Adequate storage stability data are available on cabbage
and grapes to support the storage conditions and intervals of samples
from the head lettuce and leaf lettuce field trials.  Pending submission
of storage stability data for a representative leafy vegetable to
support the 38-month frozen storage interval of celery and spinach, the
submitted leafy vegetable field trial data are adequate.

Residues of fluopicolide (parent) in/on untrimmed celery harvested at a
2-day PHI, ranged from   SEQ CHAPTER \h \r 1 0.325 ppm to 13.6 ppm.
Residues of BAM ranged from <0.01 ppm to   SEQ CHAPTER \h \r 1 0.041 ppm
(residues were only detected above the LOQ in samples from two sites)
and residues of PCA ranged from  SEQ CHAPTER \h \r 1  <0.01 ppm to   SEQ
CHAPTER \h \r 1 0.024 ppm (residues were only detected above the LOQ in
samples from one site).  Residues of fluopicolide, BAM and PCA were
nonquantifiable (<0.01 ppm) in/on all untreated celery samples.
Residues of fluopicolide increased as PHI increased in the decline study
samples. The petitioner did not provide an explanation for this
observation.  Storage stability data were not provided for celery.
Although storage stability data were provided for cabbage leaves and
grapes, the storage interval in the storage stability studies (30
months) does not reflect the maximum storage duration in the celery crop
field trial study (38 months).

  SEQ CHAPTER \h \r 1 Residue data in/on head lettuce with wrappers
ranged from 0.455 to 7.15 ppm for fluopicolide (parent).  Residues of
the metabolite PCA were less than LOD in all samples.  Residues of the
metabolite BAM were slightly above the LOQ in two samples (0.0116 and
0.0132 ppm) and were less than the LOQ in all remaining samples.  In
three samples, BAM residues were between LOD and LOQ (range of 0.0058 to
0.0094).  In head lettuce samples without wrappers, residues of
fluopicolide (parent) ranged from < 0.01 to 0.324 ppm. Residues of both
the metabolites PCA and BAM were nonquantifiable (<0.01 ppm) for all
without-wrapper samples.  For the residue decline study, average
fluopicolide residues show no general tendency to increase or decline
with increasing pre-harvest intervals.  No storage stability data are
available for head  lettuce; however, adequate stability data are
available on cabbage and grapes to support the storage conditions and
intervals of samples from the head lettuce field trials.

The residues of fluopicolide (parent) in/on leaf lettuce were greater
than the LOQ in all samples, with residues ranging from 0.444 to 11.7
ppm.  Residues of the metabolite BAM were greater than the LOQ in half
of the samples, with a maximum residue of 0.038 ppm. BAM residues in the
remaining samples were <LOQ, with residues in six of the samples between
the LOD and LOQ (0.00639 ppm to 0.00995 ppm). Residues of the metabolite
PCA were less than the LOQ in/on all samples, with residues between the
LOD and LOQ in four of the samples (0.00173 ppm and 0.00789 ppm).  In
the residue decline study, fluopicolide residues showed a general
decline with increasing preharvest intervals, decreasing from 5.50 ppm
one day after the last application to 2.33 ppm seven days after the last
application.  No storage stability data are available for leaf lettuce;
however, adequate stability data are available on cabbage and grapes to
support the storage conditions and intervals of samples from the leaf
lettuce field trials.  Residues of fluopicolide, BAM and PCA are stable
in/on cabbage leaves [Brassica (Cole) Leafy Vegetable Crop Group] and
grapes stored frozen at <-18(C for 30 months.

Residues of fluopicolide (parent) and BAM in/on spinach at the 2-day PHI
were greater than the LOQ in all samples, ranging from 5.43 to 16.80 ppm
for fluopicolide and ranging from 0.022 to 0.188 ppm for BAM.  Residues
of PCA were less than the LOD in 3 samples and between the LOD and LOQ
in 3 samples (range of 0.00822 ppm to 0.00915 ppm).  PCA residues in the
remaining samples collected at a 2-day PHI ranged from 0.0131 ppm to
0.0899 ppm.  Residues of fluopicolide, BAM and PCA were nonquantifiable
(<0.01 ppm) in/on all untreated spinach samples.  Residue decline data
showed that parent fluopicolide residues generally decrease with
increasing preharvest intervals, BAM residues remain relatively constant
with increasing preharvest intervals, and PCA residues generally
increase with increasing preharvest intervals.  Storage stability data
were not provided for spinach. Although storage stability data were
provided for cabbage leaves and grapes, the storage interval in the
storage stability studies (30 months) does not reflect the maximum
storage duration in the spinach crop field trial study (38 months).  The
submitted spinach field trial data are adequate pending submission of
storage stability data for spinach or any representative leafy vegetable
stored frozen for 38 months,.

The number and locations of the leafy vegetable field trials are in
accordance with OPPTS Guideline 860.1500 for leafy vegetable, except
Brassica, group 4.  The use pattern of the field trials adequately
reflects the use pattern proposed for leafy vegetables.  The Guidance
for Setting Pesticide Tolerances Based on Field Trial Data SOP, along
with the tolerance spreadsheet, was used to calculate the recommended
tolerance for the leafy vegetables, except brassica group.  The
available field trial data will support a tolerance for residues of
fluopicolide per se in/on leafy vegetable, except Brassica, group 4 at
25 ppm.  The tolerance calculation for leafy vegetables is presented in
Appendix II.

Fruiting vegetable, group 8

DER Reference:	46708530.der.doc (Bell pepper)

		46708535.der.doc (Chili pepper)

		46708536.der.doc (Tomato)

Valent has submitted magnitude of the residue studies for bell pepper,
non-bell (chili) pepper, and tomato, the representative crops of group
8.  The results from these field trials are discussed below and
summarized in Table 6.3.  While PCA is not a regulated metabolite,
residues for PCA are included here as they were provided by the
registrant for completeness.

Table 6.3.	Summary of Residue Data from Group 8 Crop Field Trials with
Fluopicolide.

Commodity	Total Applic. Rate

 (lb ai/A)

[kg ai/ha]	PHI (days)	Residue Levels (ppm)

	n	Min.	Max.	HAFT1	Median	Mean	Std. Dev.

BELL PEPPER (proposed use = 0.375 lb ai/A total application rate, 7-day
minimum RTI, 2-day PHI)

Fluopicolide

Bell pepper	0.349-0.358

[0.391-0.401]	2	14	0.0411	0.557	0.523	0.099	0.156	0.163

BAM

Bell pepper	0.349-0.358

[0.391-0.401]	2	14	<0.01	<0.01	NA	NA	NA	NA

PCA

Bell pepper	0.349-0.358

[0.391-0.401]	2	14	<0.01	<0.01	NA	NA	NA	NA

CHILI PEPPER (proposed use = 0.375 lb ai/A total application rate, 7-day
minimum RTI, 2-day PHI)

Fluopicolide

Chili pepper	0.355-0.363

[0.398-0.407]	2	6	0.0837	0.576	0.516	0.300	0.302	0.198

BAM

Chili pepper	0.355-0.363

[0.398-0.407]	2	6	<0.01	<0.01	NA	NA	NA	NA

PCA

Chili pepper	0.355-0.363

[0.398-0.407]	2	6	<0.01	<0.01	NA	NA	NA	NA

TOMATO (proposed use = 0.375 lb ai/A total application rate, 7-day
minimum RTI, 2-day PHI)

Fluopicolide

Tomato	0.356-0.368

[398.9-412.8]	2	24	0.015	0.420	0.375	0.145	0.150	0.094

BAM

Tomato	0.356-0.368

[398.9-412.8]	2	24	<0.01	<0.01	NA	NA	NA	NA

PCA

Tomato	0.356-0.368

[398.9-412.8]	2	24	<0.01	0.013	0.012	NA	NA	NA

1  HAFT = Highest average field trial result.

Bell pepper:  Valent U.S.A. Corporation has submitted field trial data
for fluopicolide on bell peppers.  Seven field trials (six harvest and
one decline) were conducted in the United States encompassing Zones 2 (1
trial in Georgia), 3 (1 trial in Florida), 5 (1 trial in Ohio), 6 (1
trial in Texas), and 10 (3 trials in California) during the 2002 growing
season. At each test location, there was one untreated and one treated
plot. The treated plots received three broadcast foliar applications of
EXP 11067B, formulated as a 4 lb ai/gal suspension concentrate (SC), at
5 ± 1 day retreatment intervals.  Each application was performed at a
nominal application rate of 0.119 lb ai/A, for a total seasonal
application rate of 0.357 lb ai/A/season. An adjuvant was added to the
spray mixture for all applications. At each trial location, one
untreated control and two treated mature bell pepper raw agricultural
commodity (RAC) samples were collected 2 days following the last test
substance application [2-day preharvest interval (PHI)]. In addition, at
one of the California test sites, one control and duplicate treated
mature bell pepper samples were also harvested at 1, 3, 5, and 7 days
after the last application to determine residue decline.

Bell pepper samples were analyzed for residues of fluopicolide (parent)
and its metabolites BAM (AE C653711) and PCA (AE C657188) using high
pressure liquid chromatography/triple stage quadropole mass spectrometry
(HPLC/MS/MS) Method 00782/M001. The method was adequate for data
collection based on acceptable method validation and concurrent method
recoveries.

Samples were stored frozen (≤ -20 (C) prior to analysis; the maximum
storage interval from harvest to analysis was 554 days (19 months).  No
storage stability data are available for bell peppers.

The maximum residue of fluopicolide   SEQ CHAPTER \h \r 1 was 0.557 ppm
in/on bell peppers harvested 2 days after the last of three foliar
applications of the 40% SC formulation (EXP 11067B) at a total rate of
0.349 to 0.358 lb ai/A.  Residues of BAM and PCA were each less than the
limit of quantitation (0.01 ppm) in all samples. Residue decline data
show that fluopicolide residues generally decrease with increasing
preharvest intervals.

Chili pepper:  Valent U.S.A. Corporation has submitted field trial data
for fluopicolide on chili peppers.  Three field trials were conducted in
the United States encompassing Zones 8 (1 trial in Texas), 9 (1 trial in
Arizona) and 10 (1 trial in California) during the 2002 growing season.
At each test location, there was one untreated and one treated plot.
The treated plots received three broadcast foliar applications of EXP
11067B, formulated as a 40% suspension concentrate (SC) of fluopicolide
(active ingredient) at 5 day retreatment intervals.  Each application
was performed at a nominal application rate of 0.119 lb a.i./A in spray
volumes ranging from 30.1 to 41.7 gal/A.  The achieved total seasonal
rates ranged from 0.355 to 0.363 lb a.i./A.  An adjuvant was added to
the spray mixture for all applications.

At each trial location, one untreated and two treated mature chili
pepper raw agricultural commodity (RAC) samples were collected two days
following the last test substance application [2-day preharvest interval
(PHI)].

Chili pepper samples were analyzed for residues of fluopicolide (AE
C653206) and its metabolites BAM (AE C653711) and PCA (AE C657188) using
high pressure liquid chromatography/triple stage quadropole mass
spectrometry (HPLC/MS/MS) Method 00782/M001.  Method verification was
performed prior to sample analysis and concurrent recoveries were
performed during sample analysis to demonstrate acceptable method
performance.  The limit of quantitation (LOQ) was 0.01 ppm for each
analyte for chili peppers.  The method was adequate for data collection
based on acceptable method validation and concurrent method recoveries.

Chili pepper samples were stored frozen prior to analysis; the maximum
storage interval from harvest to analysis was 508 days (17 months) prior
to extraction.  The samples were stored frozen at <-20oC.   No storage
stability data are available on chili peppers.

Fluopicolide residues were determined in/on chili peppers harvested at
the proposed PHI of 2 days after the last of three foliar applications
of the SC formulation (EXP 11067B) at a total rate of 0.355 to 0.363 lb
a.i./A.  The highest average field trial residue of fluopicolide was
0.516 ppm and the maximum residue of fluopicolide was 0.576 ppm.
Residues of BAM and PCA were each less than the limit of quantitation
(0.01 ppm) in all samples.

Tomato:  Valent U.S.A. Corporation has submitted field trial data for
fluopicolide on tomatoes.  Twelve field trials (ten harvest and two
decline) were conducted in the United States encompassing Zones 1 (1
trial in Pennsylvania), 2 (1 trial in South Carolina), 3 (2 trials in
Florida), 5 (1 trial in Michigan), and 10 (7 trials in California)
during the 2001 growing season. At each test location, there was one
untreated and one treated plot.  The treated plots received three
broadcast foliar applications of EXP 11067B, formulated as a 40%
suspension concentrate (SC) of fluopicolide (active ingredient), at 5 ±
1 day retreatment intervals.  Each application was performed at a
nominal application rate of 0.119 lb a.i./A, in spray volumes ranging
from 19.9 to 45.3 gal/A.  The achieved total seasonal rates ranged from
0.356 to 0.368 lb a.i./A.  An adjuvant was added to the spray mixture
for all applications.

At each trial location, one untreated and two treated mature tomato raw
agricultural commodity (RAC) samples were collected two days following
the last test substance application [2-day preharvest interval (PHI)].
In addition, at two California test sites (Trials 27776-08 and
27776-09), tomato RAC samples were harvested at 1, 3, 5, and 7 days
after the last application to determine residue decline.

Tomato samples were analyzed for residues of fluopicolide (AE C653206)
and its metabolites BAM (AE C653711) and PCA (AE C657188) using high
pressure liquid chromatography/triple stage quadropole mass spectrometry
(HPLC/MS/MS) Method 00782/M001.  The limit of quantitation (LOQ) was
0.01 ppm for each analyte for tomatoes.  The method was adequate for
data collection based on acceptable method validation and concurrent
method recoveries.

Tomato samples were stored frozen prior to analysis; the maximum storage
interval from harvest to extraction was 646 days (21 months).  Samples
were stored frozen at the field sites for 2 days to 4 months at
temperatures ranging from -34°F to 26.5°F, prior to storage at the
laboratory at <-15°C.  No storage data are available for tomatoes
(RAC).

The highest average field trial residue of fluopicolide was 0.375 ppm
and the maximum residue of fluopicolide was 0.420 ppm in/on tomatoes
harvested 2 days after the last of three foliar applications of the SC
formulation (EXP 11067B) at a total rate of 0.356 to 0.368 lb a.i./A.
Residues of BAM were less than the limit of quantitation (0.01 ppm) in
all samples.  Residues of PCA were less than the limit of quantitation
(0.01 ppm) in all but one sample. PCA was found in one tomato sample
from Trial 27776-1008 at a concentration of 0.013 ppm.  Residue decline
data shows a general tendency of fluopicolide residues to decrease with
increasing preharvest intervals.

Conclusions:   The submitted fruiting vegetable field trial data are
adequate.

Residues of fluopicolide (parent) were greater than the LOQ in all the
bell pepper field samples, ranging from 0.0411 to 0.557 ppm.  Residues
of the metabolite BAM were less than LOD in all samples and residues of
the metabolite PCA were less than the LOQ in all samples. In 5 samples,
PCA residues were between the LOD and LOQ (range of 0.00328 ppm to
0.00569 ppm).  Residues of fluopicolide, BAM and PCA were
nonquantifiable (<0.01 ppm) in/on all untreated bell pepper samples.
For the residue decline study, average fluopicolide residues showed a
general decline with increasing preharvest intervals, decreasing from an
average of 0.571 ppm one day after the last application to 0.380 ppm
seven days after the last application.  Storage stability data were not
provided for bell peppers; however, storage stability data on cabbage
leaves, grapes, and tomato paste and puree, which indicated stability of
fluopicolide, BAM, and PCA at <-18°C for 30 months, will be used to
support bell peppers.

Residues of fluopicolide (parent) were greater than the LOQ in all
samples, ranging from 0.0837 to 0.576 ppm. Residues of the metabolite
BAM and PCA were each less than the LOD in all samples.  Residues of
fluopicolide, BAM and PCA were nonquantifiable (<0.01 ppm) in/on all
untreated chili pepper samples.  Storage stability data were not
provided for chili peppers; however, storage stability data on cabbage
leaves, grapes, and tomato paste and puree, which indicated stability of
fluopicolide, BAM, and PCA at <-18°C for 30 months, will be used to
support chili peppers.

At the 2-day PHI, residues of fluopicolide (parent) were greater than
the LOQ in all samples, ranging from 0.015 to 0.420 ppm. Residues of the
metabolite BAM were less than the LOQ in all samples.  Residues of the
metabolite PCA were less than the LOQ in all samples except one at 0.013
ppm. Residues of fluopicolide, BAM and PCA were non-quantifiable (<0.01
ppm) in/on all untreated tomato samples.  Residue decline data shows a
general tendency of AE C638206 residues to decrease with increasing
pre-harvest intervals.  Storage stability data were not provided for the
raw agricultural commodity (RAC) tomato but storage stability data on
tomato paste and puree, which indicated stability of fluopicolide, BAM,
and PCA <-18°C for 30 months, will be used to support the RAC.

The number and representative geographical locations of the field trials
are in accordance with OPPTS Guideline 860.1500 in/on the fruiting
vegetable group.  The use pattern of the field trials adequately
reflects the use pattern proposed for fruiting vegetables.  The
available field trial data will support a tolerance for residues of
fluopicolide in/on fruiting vegetable group 8 at 1.6 ppm; the tolerance
calculation for fruiting vegetables is presented in Appendix II.

Cucurbit vegetable, group 9

DER Reference:	46708531.der.doc (Cantaloupe)

		46708532.der.doc (Cucumber)

		46708538.der.doc (Squash)

Valent has submitted magnitude of the residue studies for cantaloupe,
cucumber, and summer squash, the representative crops of group 9.  The
results from these field trials are discussed below and summarized in
Table 6.4.

Table 6.4.	Summary of Residue Data from Group 9 Crop Field Trials with
Fluopicolide.

Commodity	Total Applic. Rate

 (lb ai/A)

[kg ai/ha]	PHI (days)	Residue Levels (ppm)

	n	Min.	Max.	HAFT1	Median	Mean	Std. Dev.

CANTALOUPE (proposed use = 0.375 lb ai/A total application rate, 10-day
minimum RTI, 2-day PHI)

Fluopicolide

Cantaloupe	0.352-0.362

[0.395-0.406]	2	18	<0.01	0.258	0.181	0.055	0.068	0.061

BAM

Cantaloupe	0.352-0.362

[0.395-0.406]	2	18	<0.01	<0.01	NA	NA	NA	NA

PCA

Cantaloupe	0.352-0.362

[0.395-0.406]	2	18	<0.01	<0.01	NA	NA	NA	NA

CUCUMBER (proposed use = 0.375 lb ai/A total application rate, 10-day
minimum RTI, 2-day PHI)

Fluopicolide

Cucumber	0.349-0.361

(0.391-0.405)	2	12	<0.01	0.057	0.050	0.020	0.024	0.0147

BAM

Cucumber	0.349-0.361

(0.391-0.405)	2	12	<0.01	<0.01	NA	NA	NA	NA

PCA

Cucumber	0.349-0.361

(0.391-0.405)	2	12	<0.01	<0.01	NA 	NA	NA 	NA

SUMMER SQUASH (proposed use = 0.375 lb ai/A total application rate,
10-day minimum RTI, 2-day PHI)

Fluopicolide

Summer squash 	0.354-0.367

[0.399-0.411]	2	12	0.0135	0.0506	0.0448	0.0322	0.0301	0.0120

BAM

Summer squash 	0.354-0.367

[0.399-0.411]	2	12	<0.01	<0.01	NA	NA	NA	NA

PCA

Summer squash 	0.354-0.367

[0.399-0.411]	2	12	<0.01	0.0207	0.0173	<0.01	<0.01	0.0060

1  HAFT = Highest average field trial result.

Cantaloupe:  Valent U.S.A. Corporation has submitted field trial data
for fluopicolide on cantaloupe.  Nine field trials (eight harvest and
one decline) were conducted in the United States encompassing Zones 2 (1
trial in North Carolina), 5 (1 trial in Illinois), 6 (2 trials in
Texas), and 10 (1 trial in Arizona and 4 trials in California) during
the 2002 growing season.  At each test location, there was one untreated
and one treated plot. The treated plots received three broadcast foliar
applications of EXP 11067B, formulated as a 40% suspension concentrate
(SC) of fluopicolide (active ingredient), at 5 ± 1 day retreatment
intervals.  Each application was made at a nominal rate of 0.119 lb ai/A
for a total seasonal application rate of 0.357 lb ai/A/season. An
adjuvant was added to the spray mixture for all applications.  At each
trial location, one untreated control and two treated mature cantaloupe
raw agricultural commodity (RAC) samples were collected 2 days following
the last test substance application [2-day preharvest interval (PHI)].
In addition, at one of the California test sites, one control and
duplicate treated mature cantaloupe samples were also harvested at 1, 3,
5, and 7 days after the last application (DALA) to determine residue
decline.

Cantaloupe samples were analyzed for residues of fluopicolide (parent)
and its metabolites BAM (AE C653711) and PCA (AE C657188) using high
pressure liquid chromatography/triple stage quadropole mass spectrometry
(HPLC/MS/MS) Method 00782/M001. The method was adequate for data
collection based on acceptable method validation and concurrent method
recoveries.

Samples were stored frozen (≤ -20(C) prior to analysis; the maximum
storage interval from harvest to extraction was 560 days (19 months).
No storage stability data are available for cantaloupe.

The maximum average residue of fluopicolide (parent)   SEQ CHAPTER \h \r
1 was 0.258 ppm in/on cantaloupes harvested 2 days after the last of
three foliar applications of the 40% SC formulation (EXP 11067B) at a
total rate of 0.355 to 0.362 lb ai/A. Residues of BAM and PCA were each
less than the limit of quantitation (0.01 ppm) in all samples.

In the residue decline study, the fluopicolide residues increased and
decreased throughout the 7-day residue decline period.  At the end of
the decline period (7 DALA), average residues were only slightly less
than average residues on 1 DALA.

Cucumber:  Valent U.S.A. Corporation has submitted field trial data for
fluopicolide on cucumbers.  Six field trials (five harvest and one
residue decline) were conducted in the United States during the 2002
growing season.  Two trials were conducted in North Carolina and Georgia
(Zone 2), 1 trial in Florida (Zone 3), 1 trial each in Illinois and
Michigan (Zone 5) and 1 trial in Texas (Zone 6). Each test location
contained one control and one treated plot.  The treated plots received
three broadcast foliar applications of EXP 11067B, formulated as a 40%
suspension concentrate (SC), at 5 ± 2 day retreatment intervals.  Each
application was made at a nominal rate of 0.119 lb ai/A for a total
seasonal application rate of 0.357 lb ai/A/season.  An adjuvant was
added to the spray mixture for all applications.

At each trial location, one untreated control and two treated mature raw
agricultural commodity (RAC) samples were collected 2 days following the
last test substance application [2-day pre-harvest interval (PHI)].  In
addition, at the Georgia test site, one control and duplicate treated
RAC samples were also harvested at 1, 3, 5, and 7 days after the last
application to determine residue decline.

Cucumber samples were analyzed to quantify residues of fluopicolide
(parent) and its metabolites AE C653711 (BAM) and AE C657188 (PCA) with
high pressure liquid chromatography/triple stage quadropole mass
spectrometry (HPLC/MS/MS) using Method 00782/M001.  The method was
adequate for data collection based on acceptable method validation and
concurrent method recoveries.

RAC samples were stored frozen (<-20oC) prior to analysis.  The maximum
storage interval from harvest to analysis was 597 days (20 months).  No
storage stability data are available for cucumber.

The maximum residue of fluopicolide   SEQ CHAPTER \h \r 1 was 0.057 ppm
in/on cucumber harvested 2 days after the last of three foliar
applications of the 40% SC formulation (EXP 11067B) at a total rate of
0.349 to 0.361 lb ai/A.  Residues of BAM and PCA were each less than the
limit of quantitation (0.01 ppm) in all samples. Residue decline data
show that fluopicolide residues generally decrease with increasing
preharvest intervals.

Summer squash:  Valent U.S.A. Corporation has submitted field trial data
for fluopicolide on summer squash.  A total of six field trials (five
harvest and one decline) were conducted during the 2002 growing season
in the United States: 1 trial in Pennsylvania (Zones 1), 1 trial in
North Carolina (Zone 2), 1 trial in Georgia (Zone 2), 1 trial in Florida
(Zone 3), 1 trial in Wyoming (Zone 5), and 1 trial in California  (Zone
10). At each test location, there was one untreated and one treated
plot. The treated plots received three broadcast foliar applications of
EXP 11067B, formulated as a 40% suspension concentrate (SC), at 5 ± 2
day retreatment intervals. Each application was made at a nominal rate
of 0.119 lb ai/A for a total seasonal application rate of 0.357 lb
ai/A/season.  An adjuvant was added to the spray mixture for all
applications. At each trial location, one untreated control and two
treated mature raw agricultural commodity (RAC) samples were collected 2
days following the last test substance application [2-day pre-harvest
interval (PHI)].  In addition, at one test site, one control and
duplicate treated RAC samples were also harvested at 1, 3, 5, and 7 days
after the last application to determine residue decline.

Squash samples were analyzed for residues of fluopicolide (parent) and
its metabolites BAM (AE C653711) and PCA (AE C657188) using high
pressure liquid chromatography/triple stage quadropole mass spectrometry
(HPLC/MS/MS) Method 00782/M001. The method was adequate for data
collection based on acceptable method validation and concurrent method
recoveries.

RAC samples were stored frozen prior to analysis.  The maximum storage
interval from harvest to extraction was 624 days (21 months).  The
Analytical Report stated that the samples were stored frozen at < -20
oC. No storage stability data are available for squash.

The maximum residues of fluopicolide (parent) and PCA were 0.0506 ppm
and 0.0207 ppm in summer squash plants harvested 2 days after the last
of three foliar applications of the 40% SC formulation (EXP 11067B) at a
total rate of 0.354 to 0.367 lb ai/A. Maximum residues at a 3-day PHI
were 0.0572 ppm parent and 0.0397 PCA.  Residues of BAM were less than
the limit of quantitation of 0.01 ppm in all samples. For the residue
decline study performed at the Enigma, GA test site,
fluopicolide-derived residues increased up to 3 days after the last
application (DALA), then decreased rapidly with increasing pre-harvest
interval.

Conclusions:  The submitted cucurbit vegetable field trial data are
adequate.

The submitted cantaloupe field trial data reflect the use of three
foliar applications of the 40% SC formulation of fluopicolide (EXP
11067B) at total rates of ~0.357 lb ai/A on cantaloupes grown in the
United States with a 2-day PHI.  An acceptable method was used for
quantitation of residues in/on cantaloupes.  Residues of fluopicolide
(parent) in/on cucumber samples from the 2-day PHI ranged from <LOQ (one
sample) to 0.057 ppm.  Residues of BAM and PCA were each <LOQ in/on all
cucumber samples.  Residues of BAM were present in one sample at 0.00325
ppm and residues of PCA were detected in 7 samples at concentrations
ranging from 0.00209 to 0.00649 ppm.  For the residue decline study,
average fluopicolide residues declined with increasing preharvest
intervals; residues decreasing from an average of 0.019 ppm one day
after the last application to <LOQ seven days after the last
application.  Storage stability data were not provided for cucumber;
however, storage stability data on cabbage leaves and grapes, which
indicated stability of fluopicolide, BAM, and PCA at <-18°C for 30
months, will be used to support the stability of cucumber

The submitted cucumber field trial data reflect the use of three foliar
applications of the 40% SC formulation of fluopicolide (EXP 11067B) at
total rates of 0.349 to 0.361 lb ai/A on cucumbers grown in the United
States with a 2-day PHI.  An acceptable method was used for quantitation
of residues in/on cucumber plants.  Residues of fluopicolide (parent)
in/on cucumber samples from the 2-day PHI ranged from <LOQ (one sample)
to 0.057 ppm.  Residues of BAM and PCA were each <LOQ in/on all cucumber
samples. Apparent residues of BAM were present in one sample at 0.00325
ppm and apparent residues of PCA were detected in 7 samples at
concentrations ranging from 0.00209 to 0.00649 ppm.  Residues of
fluopicolide, BAM and PCA were nonquantifiable (<0.01 ppm) in/on all
untreated cucumber samples.   For the residue decline study, average
fluopicolide residues showed a general decline with increasing
preharvest intervals, with residues decreasing from an average of 0.019
ppm one day after the last application to <LOQ seven days after the last
application.   Storage stability data were not provided for cucumber;
however, storage stability data on cabbage leaves and grapes, which
indicated stability of fluopicolide, BAM, and PCA at <-18°C for 30
months, will be used to support cucumber.  There were no unusual weather
conditions that appear to have adversely impacted the results of the
study.  It does not appear that the agricultural practices used
adversely impacted the results of the study.

The submitted summer squash field trial data reflect the use of three
foliar applications of the 40% SC formulation of fluopicolide (EXP
11067B) at total rates of ~0.357 lb ai/A on summer squash plants grown
in the United States with a 2-day PHI.  Concurrent recoveries on squash
were acceptable.  Maximum residues for fluopicolide (parent) and its
metabolite PCA were 0.0506 ppm and 0.0207 ppm, respectively. Residues of
BAM were not detected above the LOQ in any of the summer squash samples.
There were no residues above the LOD in the squash samples from any of
the 6 trials.   Storage stability data were not provided for squash;
however, storage stability data on cabbage leaves and grapes, which
indicated stability of fluopicolide, BAM, and PCA at <-18°C for 30
months, will be used to support squash.  A residue decline study
indicated that residues at a 3-day PHI are slightly higher.  For the
residue decline study performed at the Enigma, GA test site,
fluopicolide-derived residues increased up to 3 DALA, then decreased
rapidly with increasing pre-harvest interval.

The number and locations of the field trials are in accordance with
OPPTS Guideline 860.1500 for cucurbit vegetable, group 9.  The use
pattern of the field trials adequately reflects the use pattern proposed
for cucurbit vegetables.  The available field trial data will support a
tolerance for residues of fluopicolide in/on cucurbit vegetable, group 9
at 0.50 ppm; the tolerance calculation for cucurbit vegetables is
presented in Appendix II.

Grape

DER Reference:	46708541.der.doc

Valent has submitted a magnitude of the residue study for grape; the
results from these field trials are discussed below and summarized in
Table 6.5.

Table 6.5.	Summary of Residue Data from Grape Field Trials with
Fluopicolide.

Commodity	Total Applic. Rate

 (lb ai/A)

[kg ai/ha]	PHI (days)	Residue Levels (ppm)

	n	Min.	Max.	HAFT1	Median	Mean	Std. Dev.

GRAPE (proposed use = 0.375 lb ai/A total application rate, 12-day
minimum RTI, 21-day PHI)

Fluopicolide

Grape	0.346-0.401

[0.387-0.449]	20-21	32	0.065	1.10	0.985	0.210	0.312	0.289

BAM

Grape	0.346-0.401

 [0.387-0.449]	20-21	32	<0.01	<0.01	NA	NA	NA	NA

PCA

Grape	0.346-0.401

 [0.387-0.449]	20-21	32	<0.01	0.013	0.012	<0.01	< 0.01	NA

1  HAFT = Highest average field trial result.

Valent U.S.A. Corporation has submitted field trial data for
fluopicolide on grapes.  Sixteen field trials were conducted in Canada
and the United States during the 2002 growing season in Zones 1 (2
trials in New York), 5 (4 trials in Ontario), 10 (8 trials in
California), and 11 (1 trial in Washington and 1 trial in British
Columbia). At each test location, there was one untreated and one
treated plot. The treated plots received three broadcast foliar
applications of EXP 11067B, formulated as a 4 lb ai/gal suspension
concentrate (SC), at 5 ± 1 day retreatment intervals.  Each application
was made at a nominal rate of 0.119 lb ai/A for a total seasonal
application rate of 0.346 lb ai/A to 0.401 lb ai/A (~ 1x).  The use of
an adjuvant was not mentioned in the study.  At each trial location, one
bulk untreated control and two bulk treated mature raw agricultural
commodity (RAC) samples were collected 21 ± 1 days following the last
test substance application [21-day preharvest interval (PHI)].

Grape samples were analyzed for residues of fluopicolide (parent) and
its metabolites BAM (AE C653711) and PCA (AE C657188) using high
pressure liquid chromatography/triple stage quadropole mass spectrometry
(HPLC/MS/MS) (refer to the DER for MRID 46474027). The method was
adequate for data collection based on acceptable method validation and
concurrent method recoveries.

≤-15 (C) prior to extraction; the maximum storage interval from
harvest to extraction was 219 days (7 months).  According to the
petitioner, the field sample residues were not corrected for in-storage
dissipation because of the reported stability of fluopicolide in frozen
storage. Residues of fluopicolide, BAM, and PCA are stable in/on grapes
stored frozen (≤-18 (C) for 30 months (refer to the DER for MRIDs
46474036-46474037).

The maximum residues of fluopicolide (parent) and PCA   SEQ CHAPTER \h
\r 1 were 1.10 ppm and 0.013 ppm in/on grapes harvested 20- to 21-days
after the last of three foliar applications of the 40% SC formulation
(EXP 11067B) at a total rate of 0.346 to 0.401 lb ai/A.  Residues of BAM
were below the limit of quantitation (0.010 ppm) in all samples.

Conclusions:  The submitted grape field trial data reflect the use of
three foliar applications of the 40% SC formulation of fluopicolide (EXP
11067B) at total rates ranging from 0.346 lb ai/A to 0.401 lb ai/A on
grapes grown in Canada and the United States with a 21 ± 1-day PHI.
Maximum residues for fluopicolide (parent) and its metabolite, PCA, were
1.10 ppm and 0.013 ppm, respectively.  Residues of BAM were not detected
in any of the grape samples. Acceptable storage stability data were
provided for grapes.

The number and locations of the field trials are in accordance with
OPPTS Guideline 860.1500 for grapes.  The use pattern of the field
trials adequately reflects the use pattern proposed for grapes.  The
available field trial data will support a tolerance for residues of
fluopicolide in/on grapes at 2.0 ppm.

860.1520 Processed Food and Feed

DER Reference:	46708542.der.doc (Grape)

		46708543.der.doc (Tomato)

		46708544.der.doc (Rotated wheat)

		46708545.der.doc (Potato)

  SEQ CHAPTER \h \r 1 Residue Chemistry Memo DP Number 321209,
1/23/2007, A. Acierto (PP#5E6903)

Grape

Valent U.S.A. Corporation has submitted a processing study with white
grapes harvested from the crop field trials conducted in 2000 in Europe
(Maine-et Loire, France and Hesse, Germany).

A SE10 Suspo-Emulsion (similar to a 95 g/L EC formulation) formulation
of fluopicolide was applied four times to white grapes at a ~130 g
ai/ha/application rate (~0.116 lb ai/A/application) for a total
application rate of ~520 g ai/ha (~0.46 lb ai/A), and harvested 21 days
after final treatment.  The grapes were processed into pomace and
pasteurized and non-pasteurized must, yeast, young wine, and mature wine
following typical commercial practices.  The data submitted were
reviewed in conjunction with the petition to establish tolerances for
fluopicolide on grapes and raisins (see PP#5E6903; DP Number 321209,
1/23/07, A. Acierto).

Residues of fluopicolide and its metabolites BAM and PCA in white grapes
and processed fractions were quantitated using liquid chromatography and
tandem mass spectrometry according to Method AGREDOC C024784
(IF-101/05424-00), which was developed and validated by Institut
Fresenius.  The stated limit of quantitation (LOD) was 0.01 mg/kg and
the limit of detection (LOD) was not explicitly determined, however the
petitioner assumed it to be less than 0.001 mg/kg.  This method was
deemed adequate for data collection based on acceptable concurrent
method recovery data.

The maximum storage interval from the harvest to extraction for analysis
was 25 months for grapes and 26 months for processed commodities.  A
storage stability study on grapes was previously conducted in which
residues of fluopicolide, BAM, and PCA were found to be stable in/on
grapes stored frozen (≤-18 (C) for up to 30 months.  However, no
storage stability data are available for the processed fractions.

≤0.5x average processing factors).  Residues of BAM and PCA did not
concentrate significantly in any commodity, with the following
exceptions:  residues of PCA may concentrate in pomace (average
processing factor of 2x) and non-pasteurized yeast (average processing
factor of 3x).  The processed commodities for grapes are raisin and
juice (OPPTS 860.1000).  The theoretical concentration factor for
raisins is 4.7x. (based on the loss of water on processing grapes into
raisins; OPPTS 860.1520, Table 2).  The theoretical concentration factor
for juice is 1.2x (based into separation into components; OPPTS
860.1520, Table 3).

Potato

Valent U.S.A. Corporation has submitted a study examining the transfer
of fluopicolide into processed potato commodities. The raw agricultural
commodity (RAC) was harvested 7 days following the last of three
broadcast foliar applications of EXP 11067B, formulated as a 4 lb ai/gal
suspension concentrate (SC), made at an exaggerated target application
rate of 0.59 lb ai/A/application (661 g ai/ha).  The total achieved
application rate was 1.75 lb ai/A/season (1,962 g ai/ha), approximately
5x the proposed maximum seasonal application.  The applications were
made at re-treatment intervals of 5 days.  Following harvesting, the
potatoes were processed into flakes, chips, and wet peels.

Residues of fluopicolide in/on potato samples were quantitated using
high pressure liquid chromatography/triple stage quadropole mass
spectrometry (HPLC/MS/MS) Method 00782/M001.  The method was adequate
for data collection based on acceptable method validation and concurrent
method recoveries.

The maximum storage interval of the samples (stored frozen at <-20oC)
from processing to extraction was 589 days (20 months).  Residues of
fluopicolide, BAM, and PCA are stable in/on potato tubers stored frozen
at ≤-18(C for up to 30 months (refer to the DER for MRIDs
46474036-46474037).  An adequate storage stability study on potato
processed commodities has been conducted (MRID 46708527).  The study
indicates that residues of fluopicolide, BAM, and PCA are stable in/on
potato flakes, chips and wet peels stored frozen at ≤-10 (C for up to
30 months.

Residues of fluopicolide (parent) and its metabolites were
non-quantifiable (<0.01 ppm) in the RAC samples. The processed fractions
were analyzed and fluopicolide (parent) was detected above the LOQ in
the potato wet peels at an average residue concentration of 0.049 ppm
(n=2). Fluopicolide (parent) and its metabolites (BAM and PCA) were not
detected above the LOQ in any of the other processed fractions. A
concentration factor of 4.9 was calculated for fluopicolide in the wet
peels using the LOQ (0.01 ppm) as the average fluopicolide residue in
the RAC samples. A concentration factor for the remaining processed
commodities could not be determined because fluopicolide and its
metabolites were not detected above the LOQ in the RAC and processed
commodity samples. The concentration factor in wet peel confirms the
theoretical concentration factor of 5x for potatoes.

Tomato

Valent U.S.A. Corporation has submitted a processing study with
tomatoes.  The tomatoes received three applications of a nominal 480 g/L
suspendable concentrate (SC) formulation of fluopicolide at an
exaggerated application rate of 667 g ai/ha/application (0.594 lb
ai/A/application), which was five times the proposed label rate [three
applications of the fungicide each at a rate of 133 g ai/ha (0.119 lb
ai/A)].  The total seasonal application rate was ~ 1.78 lb ai/A.
Applications were made at 5 ± 1day intervals such that the last
application was 2 days before harvest [2-day preharvest interval (PHI)].
 The tomatoes were processed into tomato puree and tomato paste.

Residues of fluopicolide and its metabolites BAM and PCA in tomatoes and
processed fractions were quantitated using liquid chromatography and
tandem mass spectrometry according to Method AGREDOC C024784
(IF-101/05424-00), which was developed and validated by Institut
Fresenius.  The stated limit of quantitation (LOQ) was 0.01 ppm for all
analytes and the limit of detection (LOD) was 0.0018 ppm for
fluopicolide (parent), 0.0018 ppm for BAM and 0.0029 ppm for PCA.  This
method was deemed adequate for data collection based on acceptable
concurrent method recovery data.

The maximum storage interval from the harvest to extraction for analysis
of tomatoes and the processed commodities was just over 12 months.  The
samples were stored frozen but the storage temperature of the samples
was not provided.  No storage stability data are available for tomato
(RAC) but storage stability data for tomato paste and puree can be used
for the RAC..  Storage stability data are available which indicate that
residues of fluopicolide and its metabolites BAM and PCA are stable at <
-10 oC for up to 30 months in tomato paste and puree (MRID 46708527).
Untreated tomato paste and puree were spiked for the storage stability
study.

Residues of fluopicolide (parent) ranged from 0.23 to 0.34 ppm in tomato
raw agricultural commodity (RAC) samples harvested 2 days following
treatment at ~ 1.78 lb ai/A/season, from 0.48 to 0.49 ppm in tomato
puree samples, and from 0.59 to 0.79 ppm in tomato paste samples.  No
residues of BAM were detected in either tomatoes or their processed
commodities.  Residues of PCA were only found at a level above the LOQ
(0.01 ppm) in one tomato paste sample at 0.011 ppm.  The processing data
indicate that residues of the parent compound fluopicolide may
concentrate in tomato puree (1.7x) and tomato paste (2.4x). Processing
factors could not be determined for BAM and PCA as the RAC samples at
the exaggerated rate did not have quantifiable residues of these
metabolites.  These concentration factors are generally in agreement
with the theoretical concentration factor of 1.4x for tomato puree and
5.5x for tomato paste (based on the loss of water on processing tomatoes
into puree and paste; OPPTS 860.1520, Table 2).

Wheat

Valent U.S.A. Corporation has submitted a processing study with rotated
wheat grain.  In a trial conducted in IL, a single spray application of
a 4 lb ai/gal suspension concentrate formulation [equivalent to a
flowable concentrate (FlC) formulation] of fluopicolide was applied to
bare soil at an exaggerated rate of 1.77 lb ai/A.  The rotational crop,
winter wheat, was planted into the treated soil 36 days after
application.  Bulk wheat grain samples were collected at normal
commercial harvest and processed into bran, flour, middlings, shorts and
germ using simulated commercial practices.

  SEQ CHAPTER \h \r 1 Samples of wheat grain and its processed
commodities   SEQ CHAPTER \h \r 1 were analyzed for residues of
fluopicolide and its metabolites BAM (AE C653711), PCA (AE C657188), P1X
(AE 1344122), and 3-OH-BAM (AE C657378) using a combined and modified
version of LC/MS/MS Methods 00782/M002 (for determination of
fluopicolide, BAM, PCA, and P1X) and 00782/M003 (for determination of
3-OH-BAM).  The extraction steps of the methods were modified to
minimize ion suppression, and the same final extract was used for
determination of all analytes.  The method was adequate for data
collection based on acceptable concurrent method recovery data.  The
validated limit of quantitation (LOQ) was 0.01 ppm for each analyte in
each wheat matrix.

 reported (≤-20 ºC).  Maximum storage intervals from harvest (RAC) or
processing to analysis were ~20 months for grain and 17 months for
processed commodities.  Adequate storage stability data are available
indicating that residues of fluopicolide, BAM and PCA are stable in/on
wheat grain stored at ≤-18 (C for up to 30 months (DP Number 321209,
1/23/07, A. Acierto) and in wheat bran, flour and shorts stored at
≤-10 (C for up to 30 months (refer to 46708527.der.doc).  In addition,
adequate storage stability data are available indicating that residues
of 3-OH-BAM and P1X are stable at ≤-18 (C for up to ~12 months in/on
wheat grain (refer to 46708418.der.doc); the petitioner has indicated
that this study is ongoing (up to 24 months).  No storage stability data
are available for residues of 3-OH-BAM or P1X in wheat processed
commodities but the storage stability data on wheat grain can be used to
support the data on processed commodities.

In wheat grain harvested at maturity following planting 36 days after
soil treatment at 1.77 lb ai/A,   SEQ CHAPTER \h \r 1 average r  SEQ
CHAPTER \h \r 1 esidues of fluopicolide were 0.017 ppm, residues of BAM
were below the LOQ (0.007 ppm), residues of PCA were 0.230 ppm, residues
of 3-OH-BAM were 0.025 ppm, and residues of P1X were 0.130 ppm.

The processing data indicate that residues of fluopicolide may
concentrate in bran, middlings, shorts, and germ, with average
processing factors of 3.0x, 1.5x, 2.0x, and 4.7x, respectively.
Residues of PCA may concentrate in bran, middlings, and shorts, with
average processing factors of 1.9x, 1.3x, and 1.8x, respectively.
Residues of 3-OH-BAM may concentrate in bran, shorts, and germ with
average processing factors of 3.0x, 1.5x, and 1.5x, respectively, and
residues of P1X appear to concentrate only in bran and shorts, with
average processing factors of 2.2x and 1.4x, respectively.  It appears
that residues of BAM may also concentrate slightly in bran, middlings,
shorts, and germ (average estimated processing factors of 1.7x, 1.1x,
1.2x, and 1.8x, respectively); however, because residues were below the
LOQ in grain, as well as middlings and shorts, these results are
inconclusive.

No concentration of residues was observed in flour; average processing
factors were estimated at 0.4x for fluopicolide, 0.7x for BAM, 1x for
PCA, 0.3x for 3-OH-BAM and 0.6x for P1X.  In addition, residues of
3-OH-BAM and P1X do not appear to concentrate in middlings, with average
processing factors of 1x, and residues of PCA and P1X do not appear to
concentrate in germ (0.9x and 0.7x respective average processing
factors).

The observed processing factors do not exceed the theoretical
concentration factors of 7.7x for bran, 1.4x for flour, and 8.3x for
shorts (based on separation into components; Table 3 of OPPTS 860.1520)
for fluopicolide and its metabolites BAM, PCA, 3-OH-BAM and P1X in wheat
flour, bran, middlings, shorts, and germ.

  SEQ CHAPTER \h \r 1 Table 7.		Summary of Processing Factors for
Fluopicolide.

RAC	Processed Commodity	Average Processing Factor 1

Fluopicolide	BAM	PCA

≥1x	NA

Wheat	Bran	3.0x	~1.7x	1.9x	2.2x

	Flour	~0.4x	~0.7x	1x	0.6x

	Middlings	1.5x	~1.1x	1.3x	1x

	Shorts	2.0x	~1.2x	1.8x	1.4x

	Germ	4.7x	~1.8x	0.9x	0.7x

1  NC = Not calculated; a processing factor could not be calculated for
this matrix as residues were below the LOQ in both the RAC and the
processed commodity.  NA = Not applicable.  Estimated (~) processing
factors were calculated when residues were reported below the LOQ in the
RAC and/or the processed matrix.

2  The observed processing factor (>4.9x) exceeded the theoretical value
of 4.0x; therefore, the theoretical value of 4.0x will be used.

3  The observed processing factors for puree (1.7-1.8x) exceeded the
theoretical value of 1.4x; therefore, the theoretical value of 1.4x will
be used.

Conclusions:  The submitted grape, potato, and tomato processing data
are adequate to satisfy data requirements.  The wheat processing study
is adequate pending submission of storage stability data for residues of
P1X on wheat grain stored frozen for 20 months to support the storage
conditions and intervals of samples of wheat grain and its processed
commodities from the rotated wheat processing study.

The grape processing data indicate that fluopicolide residues do not
concentrate in must; therefore, it is unlikely that residues would
concentrate in grape juice.  Adequate storage stability data are
available to support the grape processing studies. A tolerance for
fluopicolide residues in juice is not required.  The grape processing
data indicate that fluopicolide residues concentrate in raisins.  Based
on the HAFT residue for grapes (0.985 ppm) and the average processing
factor for raisins (3.4x), the expected residues in raisins would be 3.3
ppm.  Therefore, the recommended 6.0 ppm tolerance for raisins
(PP#5E6903) would be an appropriate tolerance for residues of
fluopicolide.

The processing data for potato indicate that fluopicolide residues do
not concentrate in chips and flakes but do concentrate in wet peels.
Adequate storage stability data are available to support the potato
processing study.  In the potato crop field trials, residues of
fluopicolide were quantifiable in only one sample, at 0.0126 ppm;
however, detectable residues (residues between the limit of detection
and the LOQ) were observed in 19 samples.  The observed processing
factor (>4.9x) exceeded the theoretical value of 4.0x for potato waste,
therefore, the theoretical value of 4.0x was used [OPPTS 8601520 (f)
(2)(ii)].  Based on the HAFT residues for fluopicolide in potato tubers
(0.011 ppm) and the average theoretical processing factor for wet peels
(4.0x), the expected residues in wet peel would be 0.05 ppm.  Because
this value is greater than the proposed 0.02 ppm tolerance for tuberous
and corm vegetables, a tolerance for processed potato waste is needed.
A tolerance of 0.05 ppm would be appropriate.

The processing data for tomato indicate that fluopicolide residues
concentrate in tomato paste and puree.  Adequate storage stability data
are available to support the tomato processing study.  Based on the HAFT
residues for tomatoes (0.375 ppm) and the average processing factors for
puree (1.4x) and paste (2.4x), expected residues would be 0.65 ppm for
puree and 0.9 ppm for paste.  Because both these values are below the
recommended tolerance of 1.6 ppm for the fruiting vegetable crop group,
no tolerances for tomato puree or paste are needed.

The processing data for wheat indicate that fluopicolide residues do not
concentrate in flour but do concentrate in bran (3.0x), middlings
(1.5x), shorts (2.0x), and germ (4.7x); PCA may concentrate in bran
(1.9x), middlings (1.3x), and shorts (1.8x); and P1X may concentrate in
bran (2.2x) and shorts (1.4x).  Storage stability data are available
which indicate stability of  fluopicolide, BAM, and PCA in wheat grain
at ≤-18°C for 30 months and stability of 3-OH-BAM and P1X in wheat
grain at ≤-18°C for 12 months.  Additional storage stability data are
needed for P1X in wheat grain for 20 months to support the storage
conditions and intervals of samples of wheat grain and its processed
commodities in the wheat processing study.  Storage stability data on
wheat grain can be translated to the processed commodities.

  SEQ CHAPTER \h \r 1 860.1650 Submittal of Analytical Reference
Standards

An analytical standard for fluopicolide, with an expiration date of
8/16/08, is currently available in the National Pesticide Standards
Repository (personal communication with Dallas Wright, ACB, 2/15/07).

An analytical reference standard for the metabolite
2,6-dichlorobenzamide (BAM) must be sent to USEPA, National Pesticide
Standards Repository/Analytical Chemistry Branch/OPP, 710 Mapes Road,
Fort George G. Meade, MD 20755-5350.

.

860.1850 Confined Accumulation in Rotational Crops

DER Reference:  46708546.der.doc

Valent U.S.A. Corporation has submitted a confined rotational crop study
with [U-14C-phenyl]fluopicolide (PH label) and
[2,6-14C-pyridinyl]fluopicolide (PY label).  Each radiolabeled test
substance was combined with nonlabeled fluopicolide, formulated as a
suspension concentrate, mixed with adjuvant, and applied to bare sandy
loam soil at a rate equivalent to 0.36 lb ai/A (400 g ai/ha); the
specific activity of the applied test substances ranged from 39.6-41.5
µCi/mg.  Rotational crops (lettuce, radish, and wheat) were planted 29,
133, and 365 days after soil treatment.  The in-life and analytical
phases of the study were conducted by Bayer CropScience (Pikeville, NC
and Frankfurt, Germany).

lated at ≥0.01 ppm in all rotated crop matrices planted at the 29-,
133-, or 365-day plantback intervals (PBIs).  TRR were highest in 29-day
PBI matrices, ranging from 0.083 ppm in radish root to 13.56 ppm in
wheat straw.  TRR decreased at the 133-day PBI, ranging from 0.02 ppm in
radish root and wheat grain to 0.84 ppm in wheat straw.  Residues
increased slightly at the 365-day PBI, ranging from 0.02 ppm in radish
root to 2.37 ppm in wheat straw.  The petitioner attributed the
increased residues in 365-day PBI matrices to seasonal variations;
133-day PBI crops were planted in October and developed over the winter,
and 365-day PBI crops were planted in March and developed over the
summer.

The majority of the radioactivity (87-97% TRR in lettuce; 86-99% in
radish top; 89-97% in radish root; 77-95% in wheat forage; 58-94% in
wheat grain; and 58-90% TRR in wheat straw) was extracted from
rotational crop matrices using acetonitrile (ACN) and ACN/water; Soxhlet
extraction with ACN/water released an additional 1-12% TRR from 29-day
PBI lettuce and radish commodities, 18-19% TRR from 29-day PBI wheat
forage, and 2-8% TRR from 133- and 365-day PBI wheat forage and 29-,
133-, and 365-day PBI wheat grain and straw.  The nonextractable
residues of wheat forage and straw were also subjected to mild acid or
base hydrolysis procedures which released 2-16% TRR (acid hydrolysis) or
9-23% TRR (base hydrolysis).  Nonextractable residues following
extraction and hydrolysis procedures accounted for <0.05 ppm in all
rotational lettuce and radish matrices, and in all rotational wheat
commodities from the 133- and 365-day PBIs; nonextractable residues in
wheat commodities from the 29-day PBI accounted for <7% TRR or <0.03
ppm.  Extraction values were normalized; reported accountabilities
before normalization were ≥97% for all commodities with the following
exceptions:  365-day PBI lettuce (89%; PH label); 133-day radish top
(92%; PH label); 365-day PBI radish root (95%; PH label); 365-day PBI
wheat grain (94%; PH label); and 133-day PBI wheat straw (93%; PY
label).

Residues were identified and quantitated primarily by HPLC, with
confirmation and structure elucidation using LC/MS, LC/MS/MS, and NMR
analyses.  Fluopicolide and seven discrete metabolites were identified
in rotational crops by HPLC analysis.  Because of the two-ring structure
of fluopicolide, metabolites resulting from cleavage of fluopicolide at
the bond between the carbon attached to the pyridine ring and the amide
nitrogen of the parent compound were identified in either PH samples
[metabolites AE C653711 (BAM) and AE 657378 (3-OH-BAM)] or PY samples
[AE C657188 (PCA), AE 653598, AE 1344122, and AE B102859].  Fluopicolide
and the double-ring metabolite AE C643890 were identified in both phenyl
and pyridinyl labeled samples.

e metabolites AE C653598 (365-day PBI lettuce only) and AE B102859 were
also identified in PY samples, at ≤9% TRR each.

In radish root, total identified residues ranged from 81-91% TRR.
Fluopicolide was identified in all radish root samples, at 24.2-55.8%
TRR (0.006-0.069 ppm); fluopicolide was found at >0.01 ppm in all
samples with the exception of PH label 133- and 365-day PBI samples.
The major metabolite in PH label samples was AE C653711, at 43.2-60.9%
TRR (0.013-0.062 ppm).  In PY samples, AE 1344122 and AE C657188 were
identified at all PBIs, at 2.9-9.6% TRR for AE 1344122 and 9.6-33.5% TRR
for AE C657188.  The metabolite AE C653598 was identified in 365-day PBI
root at 9.5% TRR, and metabolite AE B102859 was identified in 133-day
root, at 19.1% TRR.

h present at ≤6.2% TRR (≤0.307 ppm).  These metabolites, P2ab, P2c,
P4a, P4b, P4c, P5, P10, and P11, were proposed to be hydroxylated or
sulfhydrylated versions of fluopicolide or its metabolites, with or
without conjugation to glucose, malonic acid, glyceric acid or amino
acid.

In wheat grain, total identified residues ranged 44-50% TRR in PH
samples and 81-85% TRR in PY samples.  Fluopicolide was identified in
all wheat grain samples, at 1.8-27.3% TRR (0.001-0.046 ppm);
fluopicolide was found at >0.01 ppm only in 29-day PBI samples.  At the
29-day PBI, the major metabolites were AE C643890 (13.1% TRR, 0.021 ppm;
PH label) and AE C657188 (69.6% TRR, 1.809 ppm; PY label); AE C657188
was found at lower levels in 133- and 365-day PBI samples (10.9-14.2%
TRR, 0.010-0.025 ppm).  In 133- and 365-day PBI samples, the major
metabolites were AE 1344122 (64.9-66.6% TRR, 0.064-0.116 ppm; PY label),
AE C657378 (23.3-24.5% TRR, 0.005-0.013 ppm; PH label), and AE C653711
(17.9-19.0% TRR, 0.004-0.010 ppm; PH label).  AE 1344122 and AE C653711
were identified in 29-day PBI samples, at 13.1% TRR (0.341 ppm; PY
label) and 3.6% TRR (0.006 ppm; PH label), respectively.

 TRR (1.100-1.166 ppm) in wheat straw, and metabolites P8a and P8b
together accounted for 7.1-9.9% TRR; the remaining metabolites were
present at ≤6.0% TRR.

HED notes that, in general, the levels of fluopicolide were found to
decrease significantly with increasing PBI in the PH label samples.  The
same trend was not observed in PY samples; fluopicolide levels in PY
samples were generally the same at all three PBIs.

All samples were initially extracted within 114 days of harvest, with
the exception of 365-day PBI wheat grain and straw, which were extracted
180-194 days after collection.  Samples of 133- and 365-day PBI
commodities were analyzed within 19.5 months of collection, and samples
of 29-day PBI commodities were analyzed within 39.0 months of
collection.  Adequate storage stability data were provided to support
the storage intervals and conditions of all samples from this study.

Based on the submitted confined rotational crop study, the petitioner
proposed a metabolic pathway for fluopicolide in rotational crops; see
Figure C.3.1.  The metabolism of fluopicolide in rotational crops
appears to be more extensive than that observed in primary crops
(grapes, lettuce, and potato; refer to the DERs for MRIDs 46474026,
46708520, and 46708521).  The major metabolites identified were AE
C653711 (BAM), AE C657188 (PCA), AE 1344122 (P1X) and AE C657378
(3-OH-BAM).   P1X, 3-OH-BAM, and two other rotational crop metabolites
(AE C653598, 3-chloro-5-(trifluoromethyl)-2-pyridine carboxamide, and AE
B102859, 3-chloro-5-(trifluoromethyl)-2-pyridinol) were not observed in
the primary crop metabolism studies.  The petitioner did not provide any
information on whether any of the observed metabolites were known soil
degradates.

Based on the submitted confined rotational crop study, the petitioner
proposed a metabolic pathway for fluopicolide in rotational crops; the
proposed pathway is presented in Appendix III.

Conclusions:   The submitted confined rotational crop data are adequate
to satisfy data requirements.  The metabolism of fluopicolide in
rotational crops appears to be more extensive than that observed in
primary crops (grapes, lettuce, and potato); four rotational crop
metabolites, 3-OH-BAM, P1X, AE C653598, and AE B102859, were not
observed in the primary crop metabolism studies.

Adequate storage stability data were provided to support the storage
intervals and conditions of all samples from this study.

The submitted confined rotational crop studies indicate the potential
for quantifiable fluopicolide and metabolite residues in rotated crop
commodities.  In HED’s RARC1 meeting held on 7/19/07, HED determined
that the residue of concern for the tolerance expression for rotational
crops is fluopicolide (parent).  The residues of concern for the risk
assessment for cereal grains as rotational crops are fluopicolide
(parent), BAM, PCA, and P1X in grain for human food, and fluopicolide
(parent) and BAM in forage/hay/straw and grain for livestock feed.  The
residues of concern for the risk assessment for all rotational crops
except cereal grains are fluopicolide (parent) and BAM.

860.1900 Field Accumulation in Rotational Crops

DER Reference:  46708547.der.doc

Valent U.S.A. Corporation has submitted the results of an extensive
field rotational crop study on wheat.  Twenty-one field trials were
conducted in Zones 2 (NJ; 1 trial), 4 (AR; 1 trial), 5 (IL, MI, NE, WI,
and OH; 6 trials), 6 (TX; 1 trial), 7 (ND, NE, SD; 5 trials), 8 (CO, KS,
NM, and TX; 6 trials) and 11 (WA; 1 trial) during the 2001-2002 growing
season.

The results from the rotational crop field trials show that maximum
residues of fluopicolide, BAM,  PCA, and P1X were, respectively, 0.213,
0.123, , 0.043, and 0.064 ppm in/on wheat forage; 0.501, 0.102,  0.064,
and 0.073 ppm in/on hay; 0.014, <0.01,  0.062 and 0.075 ppm in/on grain;
and 0.350, 0.050, 0.043, and 0.055 ppm in/on straw planted 29 to 37 days
following the last application of fluopicolide to a primary crop of
potatoes at 0.346-0.372 lb ai/A.

Table 8.		Summary of Residue Data in Rotational Wheat Commodities
Following Treatment of a Primary Crop with Fluopicolide.

Commodity	Applic. Rate

(lb ai/A)

[g ai/ha]	PBI

(days)	Analyte	Residue Levels (ppm)

n	Min.	Max.	HAFT1	Median	Mean	Std. Dev.

Wheat, forage	0.346-0.372

[388-417]	29-37	Fluopicolide	42	<0.01	0.213	0.160	0.027	0.044	0.047

	BAM	42	<0.01	0.123	0.106	0.019	0.028	0.027

	PCA	42	<0.01	0.043	0.027	0.010	0.013	0.007

	P1X	42	<0.01	0.064	0.057	0.012	0.018	0.013

Wheat, hay	0.346-0.372

[388-417]	29-37	Fluopicolide	42	0.014	0.501	0.364	0.051	0.100	0.119

	BAM	42	<0.01	0.102	0.095	0.010	0.022	0.024

	PCA	42	<0.01	0.064	0.055	0.010	0.018	0.013

	P1X	42	<0.01	0.073	0.070	0.025	0.028	0.017

Wheat, grain	0.346-0.372

[388-417]	29-37	Fluopicolide	42	<0.01	0.014	0.014	0.010	0.010	0.001

	BAM	42	<0.01	<0.01	<0.01	0.010	0.010	0.000

	PCA	42	<0.01	0.062	0.060	0.011	0.016	0.011

	P1X	42	<0.01	0.075	0.075	0.019	0.025	0.020

Wheat, straw	0.346-0.372

[388-417]	29-37	Fluopicolide	42	<0.01	0.350	0.338	0.034	0.055	0.075

	BAM	42	<0.01	0.050	0.050	0.010	0.015	0.011

	PCA	42	<0.01	0.043	0.040	0.010	0.012	0.007

	P1X	42	<0.01	0.055	0.049	0.020	0.021	0.011

1  HAFT = Highest average field trial result.

Conclusions:   Under the conditions and parameters used in the study,
the data depicting residues in the rotational crop wheat are tentatively
classified as scientifically acceptable, pending submission of
additional storage stability data reflecting the stability of  P1X in
wheat grain for 21 months and for fluopicolide and BAM in wheat forage
and straw for 24 months.  The available storage stability data for wheat
straw will be translated to wheat hay.

The tolerance calculation for wheat is presented in Appendix II.

In the confined rotational crop study, residues of fluopicolide >0.01
ppm were observed in/on all rotational crop commodities at all PBIs,
with the exception of wheat grain at the 133- and 365-day PBIs.  Based
on these results and the proposed rotational crop restrictions, limited
field rotational crop studies must be conducted at a 12-month PBI with
representative leafy vegetable, root vegetable, and cereal grain crops.
Although the petitioner is proposing a 30-day PBI for wheat and has
submitted supporting field rotational crop data, limited field
rotational crop data for another cereal grain, preferably a small grain,
are needed to represent all grain crops other than wheat that may be
rotated at a 12-month PBI.  If the results of the limited field
rotational crop studies indicate the potential for quantifiable
fluopicolide residues of concern in/on rotational crops at a 12-month
PBI, then extensive field rotational crop studies will be required for
all crops the petitioner wishes to allow for rotation at a 12-month PBI.

860.1550 Proposed Tolerances

HED is recommending a revision of the proposed tolerance expression for
fluopicolide in/on plants to address issues of quantifiable residues
2,6-dichlorobenzamide (BAM) in/on RACs resulting from fluopicolide
application. HED has determined that the terminal residue of concern in
cucurbit vegetable, fruiting vegetable, grape, leafy vegetable, and
tuberous and corm vegetable commodities for the tolerance expression is
fluopicolide
[2,6-dichloro-N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]benzam
ide] as an indicator of combined residues of fluopicolide and its
metabolite, 2,6-dichlorobenzamide.

No Codex, Canadian, or Mexican MRLs have been established for
fluopicolide.

Pending submission of the requested storage stability data/information,
adequate field trial data are available for tuberous and corm vegetables
(subgroup 1C), leafy vegetables (except Brassica, group 4), fruiting
vegetables (group 8), cucurbit vegetables (group 9), and grapes.  The
available field trial data will support tolerances for residues of
fluopicolide in/on grape at 2.0 ppm, the cucurbit vegetable group 9 at
0.50 ppm, the fruiting vegetable group 8 at 1.6 ppm, the leafy
vegetable, except brassica, group 4 at 25 ppm, and the tuberous and corm
vegetable (subgroup 1D except potato) at 0.02 ppm.  Because the majority
of residues in potatoes were below the LOQ, the tolerance spreadsheet in
the Agency’s Guidance for Setting Pesticide Tolerances Based on Field
Trial Data was not utilized for determining an appropriate tolerance
level for the tuberous and corm vegetable subgroup.  The tolerance
calculations for cucurbit vegetables, fruiting vegetables, leafy
vegetables, and grapes are presented in Appendix II.  The data indicate
that the proposed tolerances of 0.8 ppm and 20 ppm for the fruiting
vegetable and leafy vegetable crop groups are too low; increased
tolerances of 1.6 ppm and 25 ppm are needed.

Pending submission of the requested storage stability information,
adequate extensive field rotational crop data are available for wheat
forage, hay, grain, and straw.  The available field trial data will
support tolerances for indirect or inadvertent residues of fluopicolide
in/on wheat forage at 0.20 ppm, wheat hay at 0.50 ppm, wheat grain at
0.02 ppm, and wheat straw at 0.50 ppm; the tolerance calculation for
rotated wheat forage, hay, and straw are presented in Appendix II.  For
wheat grain, the majority of residues were below the LOQ; therefore, the
tolerance spreadsheet was not used for wheat grain.

Adequate processing data for grapes, potatoes, tomatoes, and wheat are
available pending submission of the requested storage stability
data/information.  The available processing data indicate that residues
of fluopicolide are not likely to concentrate in grape juice, in potato
chips and flakes, or in wheat flour.  Residues of fluopicolide were
found to concentrate in raisins, processed potato waste (wet peels),
tomato paste and puree, and wheat milled byproducts (bran, germ,
middlings, and shorts).  The processing data indicate that the proposed
tolerance of 6 ppm for raisins is appropriate.  In addition, tolerances
for processed potato waste and wheat milled byproducts must be proposed,
at 0.05 ppm and 0.07 ppm, respectively.  Separate tolerances for tomato
processed commodities are not needed as residues in these commodities
are not expected to exceed the recommended tolerance of 1.6 ppm for the
fruiting vegetable group.

The available cattle feeding study data indicate that tolerances for
ruminant and swine commodities are not needed to support the requested
fluopicolide uses.  The need for tolerances for poultry commodities will
be determined after the required poultry metabolism data have been
submitted.

The proposed tolerances should be revised to reflect the recommended
tolerance levels and correct commodity definitions as specified in Table
9; individual tolerances for the members of each of the requested crop
groups are not needed.  Tolerances to be established when rotational
crop and livestock issues are resolved are specified in Table 10.

Table 9. 	Tolerance Summary for Fluopicolide.

Commodity	Proposed Tolerance (ppm)	Recommended Tolerance (ppm)	Comments;
Correct Commodity Definition

Tolerances to be established under “(a) General” (1):

Tuberous and corm vegetables subgroup 1C

Arracacha 	0.02	0.02	Vegetable, tuberous and corm, except potato,
subgroup 1D

Arrowroot 	0.02

Artichoke, Chinese 	0.02

Artichoke, Jerusalem 	0.02

Canna, edible 	0.02

Cassava, bitter and sweet 	0.02

Chayote (root) 	0.02

Chufa 	0.02

Dasheen 	0.02

Ginger 	0.02

Leren 	0.02

Sweet potato 	0.02

Tanier 	0.02

Turmeric 	0.02

Yam bean 	0.02

Yam, true 	2

Vegetable, leafy, except brassica, group 4

Head Lettuce 	20	25	Vegetable, leafy, except brassica, group 4

Leaf Lettuce 	20

Spinach 	20

Arugula 	20

Chervil 	20

Chinese spinach 	20

Corn salad 	20

Dandelion 	20

Dock (sorrel) 	20

Edible chrysanthemum 	20

Endive 	20

Garden cress 	20

Garden purslane 	20

Garland Chrysanthemum 	20

New Zealand spinach 	20

Orach 	20

Parsley 	20

Red chicory 	20

Upland cress 	20

Vine spinach 	20

Winter purslane 	20

Cardoon 	20

Celery 	20

Celtuce 	20

Chinese celery 	20

Fennel 	20

Rhubarb 	20

Swiss chard 	20

Vegetable, fruiting, group 8

Tomato/Cherry tomato 	0.8	1.6	Vegetable, fruiting, group 8

Sweetpepper 	0.8

Bell pepper 	0.8

Chili pepper 	0.8

Cooking pepper 	0.8

Pimiento 	0.8

Eggplant 	0.8

Groundcherry 	0.8

Pepino 	0.8

Tomatillo 	0.8

Vegetable, cucurbit, group 9

Cantaloupe 	0.4	0.50	Vegetable, cucurbit, group 9

Citron melon 	0.4

Muskmelon 	0.4

Watermelon	0.4

Chayote (fruit) 	0.4

Chinese waxgourd 	0.4

Cucumber 	0.4

Gherkin 	0.4

Gourd, edible 	0.4

Momordica spp 	0.4

Pumpkin 	0.4

Squash, summer 	0.4

Squash, winter 	0.4

Other

Grape 	2	2.0

	Raisins 	6	6.0	Grape, raisin

Tolerances to be established when rotational crop and livestock issues
are resolved are specified in Table 10.

Table 10. 	Tolerance Summary for Fluopicolide  (To be Established When
Deficiencies are Resolved).

Commodity	Proposed Tolerance (ppm)	Recommended Tolerance (ppm)	Comments;
Correct Commodity Definition

Tolerances to be established under “(a) General” (1):

Tuberous and corm vegetables subgroup 1C

Potato 	0.02	0.02	Vegetable, tuberous and corm, subgroup 1C

Other

Potato, processed potato waste	None proposed	0.05

	Tolerances to be established under “(a) General” (2):

Cattle fat	None proposed	0.05	Cattle, fat

Cattle meat	None proposed	0.02 	Cattle, meat

Cattle meat byproducts	None proposed	0.05	Cattle, meat byproducts

Goat fat	None proposed	0.05	Goat, fat

Goat meat	None proposed	0.02 	Goat, meat

Goat meat byproducts	None proposed	0.05	Goat, meat byproducts

Horse fat	None proposed	0.05 	Horse, fat

Horse meat	None proposed	0.02 	Horse, meat

Horse meat byproducts	None proposed	0.05 	Horse, meat byproducts

Milk	None proposed	0.01 	Milk

Sheep fat	None proposed	0.05 	Sheep, fat

Sheep meat	None proposed	0.02	Sheep, meat

Sheep meat byproducts	None proposed	0.05 	Sheep, meat byproducts

Tolerances to be established under “(d) Indirect or inadvertent
residues”:

Wheat forage 	0.2	0.20	Wheat, forage

Wheat grain 	0.02	0.02	Wheat, grain

Wheat hay 	0.5	0.50	Wheat, hay

Wheat straw 	0.5	0.50	Wheat, straw

Wheat, milled byproducts	None proposed	0.07

	Wheat, aspirated grain fractions	None proposed	0.07

References

DP #:	329686

Subject:	Fluopicolide (AE C638206) in/on imported grapes, domestic use
in/on food crops and ornamental turf.  Request for Petition Method
Validation.

From:	A. Acierto

To:	F. Siegelman

Date:	6/8/07

MRIDs:	46474027-46474031, 46708522-46708525 and 46708516

DP #:			321209

Subject: 		Fluopicolide. PP#5E6903; Petition for Tolerances on Imported
Grapes and Raisins.  Summary of Analytical Chemistry and Residue Data.

From: 			Amelia M. Acierto

To:			Janet Whitehurst /Tony Kish

Date:			1/23/07

MRIDs:		46474025, 46474026, 46474027, 46474028, 46474029, 46474030,
46474031, 46474032, 46474033, 46474034, 46474035, 46474036, 46474037,
46474038, 46474039, 46474040, 46474041, 46474042, 46474043, 46474044,
46474045; 46474101, 46474102, 46474103, 46474104, 46474105, 46474106;
46708525, 46708542.

DP Number:	339155

Subject:	PP# 5E6903 & 5F7016.  Review of Revised Proposed Tolerance
Enforcement Method for Fluopicolide.  PC Code:027412.  DBarcode: D329578
& D329670.  ACB Project #:B06-22.

From:	Charles Stafford

To:	A. Acierto

Date:	3/14/07

MRIDs:	None.  Valent Report Number C20070031

DP #:			339157

Subject: 		PP#5E6903.  Fluopicolide.  Amendment to Address the
Requirements to Establish Tolerances on Imported Grapes and Raisins.

From: 			Amelia M. Acierto

To:			Janet Whitehurst /Tony Kish

Date:			6/01/07

DP Number:	318332

Subject:	FEE.  Secondary Product Chemistry Review on Fluopicolide
technical (Import Tolerance)

From:	S. Mathur

To:	J. Whitehurst/T. Kish

Date:	10/17/06

MRIDs:	46474001-46474023, 46478409, and 46478410

  SEQ CHAPTER \h \r 1 Attachments:

International Residue Limit Status sheet

Appendix I - Chemical Name and Structure Table

Appendix II - Tolerance Assessment Calculations

Appendix III - Proposed Metabolic Pathway for Fluopicolide in Rotational
Crops

INTERNATIONAL RESIDUE LIMIT STATUS

Chemical Name:
2,6-dichloro-N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-benzam
ide	Common Name:  Fluopicolide	X Proposed tolerance

( Reevaluated tolerance

√ No Codex proposal step 6 or above

No Codex proposal step 6 or above for the crops requested	Petition
Number:  PP#5F7016

DP Number:  327026

√ No Limits

No Limits for the crops requested	√ No Limits

No Limits for the crops requested

Residue definition:  N/A

	Residue definition:  N/A

Crop(s)	MRL (mg/kg)	Crop(s)	MRL (mg/kg)

	Notes/Special Instructions:

S. Funk, 02/20/2007.

Appendix I.  Chemical Names and Structures of Fluopicolide and its
Transformation Products.

Common name/code	Chemical name	Chemical structure

Fluopicolide

AE C638206
2,6-dichloro-N-[[3-chloro-5-(trifluoromethyl-2-pyridinyl]methyl]benzamid
e

AE C653711

BAM	2,6-dichlorobenzamide

AE C657188

PCA	3-chloro-5-trifluoromethylpyridine-2-carboxylic acid

AE C657378

3-OH-BAM or BAM-OH	2,6-dichloro-3-hydroxybenzamide

AE 1344122

P1X	3-methylsulfinyl-5-trifluoromethylpyridine-2-carboxylic acid

AE 0608000
N-[(3-chloro-5-trifluoromethylpyridin-2-yl)(hydroxy)methyl]-2,6-dichloro
benzamide

AE 0712556
2,6-dichloro-N-[(3-chloro-5-trifluoromethyl-2-pyridyl)methyl]-4-hydroxyb
enzamide

AE B102859

(Pyridinol)	3-chloro-5-(trifluoromethyl)-2-pyridinol

AE C643890
2,6-dichloro-N-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)methyl]-3-hydr
oxybenzamide

AE C653598	3-chloro-5-(trifluoromethyl)-2-pyridine carboxamide

Dihydroxy glucuronide of fluopicolide

Dihydroxy sulfate of fluopicolide

Hydroxy glucuronide of fluopicolide

Hydroxy sulfate of fluopicolide

Metabolite 1
2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-3-(met
hylsulfonyl)benzamide

P2ab

P2a and P2b proposed to be isomers with differences in chromatographic
behavior

P2c

P4a

P4b

P4c

P5

P8a

Two components characterized as glucoside conjugates

P8b

Position of hydroxylation and OR1 and SR2 unknown

P10

isomer to P8b; position of hydroxylation and OR1 and SR2 unknown

P11

Appendix II.  Tolerance Assessment Calculations.

For each of the crops listed below, the Guidance for Setting Pesticide
Tolerances Based on Field Trial Data SOP, along with the tolerance
spreadsheet, was used for calculating recommended tolerances.  As
specified in the SOP, the minimum of the 95% upper confidence limit
(UCL) on the 95th percentile and the point estimate of the 99th
percentile was selected as the tolerance value in cases when the dataset
was large (greater than 15 samples) and reasonably lognormal.  For
datasets that were small (≤15 samples) and reasonably lognormal, the
upper bound estimate of the 95th percentile based on the median residue
value was compared to the minimum of the 95% UCL on the 95th percentile
and the point estimate of the 99th percentile, and the minimum value was
selected as the tolerance value.  For datasets that were not lognormal,
the upper bound on the 89th percentile was selected as the tolerance
value (distribution-free method).  The rounding procedures specified in
the SOP were also used.

Tuberous and corm vegetables, Crop group 1,  Subgroup 1C

The dataset used to establish a tolerance for fluopicolide on the
tuberous and corm vegetables consisted of field trial data for potato,
representing application rates of 0.36 lb ai/A (3 applications at 0.119
lb ai/A/application) with a 7-day PHI.  As specified by the Guidance for
Setting Pesticide Tolerances Based on Field Trial Data SOP, the field
trial application rates and PHIs are within 25% of the maximum label
application rate and minimum label PHI, respectively.  The fluopicolide
residue values were less than the LOQ (<0.01 ppm).   Values below the
LOQ are generally referred to as censored data.   The use of maximum
likelihood estimation (MLE) techniques to estimate the mean and standard
deviation of dataset is normally recommended if more than 10-15% of the
dataset is censored but not for datasets with large degree of censoring
(i.e., >60%) since the technique becomes unreliable.  Since the residues
of fluoicolide were below the LOQ in/on all potato tuber samples, except
one in which the residue was detected at 0.013, ppm, no calculation was
necessary.

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 II-1.

All field trial sample results were above the LOQ and each dataset was
small (less than 15 samples).  Since there were no values reported below
the LOQ, maximum likelihood estimation (MLE) procedures were not needed
to impute censored values.

The dataset for each crop was entered into the tolerance spreadsheet.
Visual inspection of the lognormal probability plots for celery, head
lettuce, and spinach (Figures II-1, II-3, and II-7) provided in the
spreadsheet indicate that with the exception of leaf lettuce, the
datasets are each reasonably lognormal.  The results from the
approximate Shapiro-Francia test statistic (Figures II-2, II-4, and
II-8) confirmed that the assumption of lognormality should not be
rejected for celery, head lettuce, or spinach.  For leaf lettuce, the
result from the approximate Shapiro-Francia test statistic (Figure II-6)
indicated that the assumption of lognormality should be rejected, and
visual inspection of the lognormal probability plot (Figure II-5)
confirmed that the dataset is not lognormal.

Using the tolerance spreadsheet, the recommended tolerances were 25 ppm
for celery, 17 ppm for head lettuce, 16 ppm for leaf lettuce, and 25 ppm
for spinach.  Because the minimum and maximum recommended tolerances
differ by less than 5x, a crop group tolerance is appropriate for leafy
vegetable.  The recommended value is 25 ppm, the maximum of the
recommended individual tolerances.

Table II-1.	Residue data used to calculate tolerance for fluopicolide on
the leafy vegetable (except Brassica) crop group.

Regulator:	EPA	EPA	EPA	EPA

Chemical:	Fluopicolide	Fluopicolide	Fluopicolide	Fluopicolide

Crop:	Celery (untrimmed)	Head lettuce	Leaf lettuce	Spinach

PHI:	2 days	2 days	2 days	2 days

App. Rate:	3 at 0.119 lb ai/A/application	3 at 0.119 lb ai/A/application
3 at 0.119 lb ai/A/application	3 at 0.119 lb ai/A/application

Submitter:	Valent U.S.A.	Valent U.S.A.	Valent U.S.A.	Valent U.S.A.

MRID Citation:	46708539	46708533	46708534	46708540

	Residues of Fluopicolide (ppm)

	4.900	2.080	7.860	6.860

	5.200	2.450	11.700	6.130

	1.110	0.455	7.610	11.800

	1.350	0.500	6.290	15.500

	6.680	1.180	4.330	5.430

	6.530	2.330	3.330	6.840

	0.983	0.475	4.990	15.500

	1.030	0.616	0.444	16.800

	0.762	4.160	6.560	8.550

	0.325	3.450	7.550	8.510

	6.100	4.320	5.300	11.500

	13.600	2.880	3.860	9.210

5.520	9.020	6.480

7.150	10.300	6.780

Figure II-   SEQ Figure_II- \* ARABIC  1 .  Lognormal probability plot
of fluopicolide field trial data for untrimmed celery.

Figure II- 2.   Tolerance spreadsheet summary of fluopicolide field
trial data for untrimmed celery.

Figure II- 3.  Lognormal probability plot of fluopicolide field trial
data for head lettuce.

Figure II- 4.   Tolerance spreadsheet summary of fluopicolide field
trial data for head lettuce.

Figure II- 5.  Lognormal probability plot of fluopicolide field trial
data for leaf lettuce.

Figure II- 6.   Tolerance spreadsheet summary of fluopicolide field
trial data for leaf lettuce.

Figure II- 7.  Lognormal probability plot of fluopicolide field trial
data for spinach.

Figure II- 8.   Tolerance spreadsheet summary of fluopicolide field
trial data for spinach.

Fruiting vegetable, group 8

The dataset used to establish a tolerance for fluopicolide on the
fruiting vegetable crop group consisted of field trial data for bell
pepper, chili pepper, and tomato, representing application rates of 0.36
lb ai/A (3 applications at 0.119 lb ai/A/application) with a 2-day PHI.
As specified by the Guidance for Setting Pesticide Tolerances Based on
Field Trial Data SOP, the field trial application rates and PHIs are
within 25% of the maximum label application rate and minimum label PHI,
respectively.  The residue values used to calculate the tolerance are
provided in Table II-2.

All field trial sample results were above the LOQ.  Since there were no
values reported below the LOQ, MLE procedures were not needed to impute
censored values.  The datasets for bell and chili pepper were each <15
samples, and the combined dataset was >15 samples; these datasets were
entered into the tolerance spreadsheet separately and together.  The
dataset for tomato was >15 samples.

The dataset for each crop was entered into the tolerance spreadsheet.
Visual inspection of the lognormal probability plots (Figures II-9,
II-11, II-13, and II-15) provided in the spreadsheet indicate that the
datasets are each reasonably lognormal.  The results from the
approximate Shapiro-Francia test statistic (Figures II-10, II-12, II-14,
and II-16) confirmed that the assumption of lognormality should not be
rejected.  Because the combined bell pepper and nonbell pepper dataset
was found to be reasonably lognormal, the combined data were used for
tolerance setting purposes.

Using the tolerance spreadsheet, the recommended tolerances were 1.1 ppm
for bell and nonbell pepper and 0.70 ppm for tomato.  Because the
minimum and maximum recommended tolerances differ by less than 5x, a
crop group tolerance is appropriate for fruiting vegetable.  The
recommended value is 1.1 ppm, the maximum of the recommended individual
tolerances.

Table II-2.	Residue data used to calculate tolerance for fluopicolide on
the fruiting vegetable crop group.

Regulator:	EPA	EPA	EPA

Chemical:	Fluopicolide	Fluopicolide	Fluopicolide

Crop:	Bell pepper	Chili pepper	Tomato

PHI:	2 days	2 days	2 days

App. Rate:	3 at 0.119 lb ai/A/application	3 at 0.119 lb ai/A/application
3 at 0.119 lb ai/A/application

Submitter:	Valent U.S.A.	Valent U.S.A.	Valent U.S.A.

MRID Citation:	46708530	46708535	46708536

	Residues of Fluopicolide (ppm)

	0.047	0.096	0.200

	0.041	0.084	0.280

	0.092	0.358	0.190

	0.060	0.241	0.190

	0.167	0.456	0.053

	0.095	0.576	0.041

	0.148

0.170

	0.103

0.170

	0.194

0.150

	0.104

0.130

	0.044

0.081

	0.041

0.058

	0.489

0.083

	0.557

0.100

	0.190

	0.130

	0.015

	0.062

	0.170

	0.140

	0.330

	0.420

	0.100

	0.150

Figure II- 9.  Lognormal probability plot of fluopicolide field trial
data for bell pepper.

Figure II- 10.   Tolerance spreadsheet summary of fluopicolide field
trial data for bell pepper.

Figure II- 11.  Lognormal probability plot of fluopicolide field trial
data for chili pepper.

Figure II- 12.   Tolerance spreadsheet summary of fluopicolide field
trial data for chili pepper.

Figure II- 13.  Lognormal probability plot of fluopicolide field trial
data for bell and nonbell pepper.

Figure II- 14.   Tolerance spreadsheet summary of fluopicolide field
trial data for bell and nonbell pepper.

Figure II- 15.  Lognormal probability plot of fluopicolide field trial
data for tomato.

Figure II- 16.   Tolerance spreadsheet summary of fluopicolide field
trial data for tomato.

Cucurbit vegetable, group 9

The dataset used to establish a tolerance for fluopicolide on the
cucurbit vegetable crop group consisted of field trial data for
cantaloupe, cucumber, and summer squash, representing application rates
of 0.36 lb ai/A (3 applications at 0.119 lb ai/A/application) with a
2-day PHI.  As specified by the Guidance for Setting Pesticide
Tolerances Based on Field Trial Data SOP, the field trial application
rates and PHIs are within 25% of the maximum label application rate and
minimum label PHI, respectively.  The residue values used to calculate
the tolerance are provided in Table II-3.

All field trial sample results for summer squash were above the LOQ and
11 of 12 sample results for cucumber were above the LOQ; each dataset
consisted of 12 samples.  For cantaloupe, 3 of the 16 sample results
were below the LOQ.  Since less than 10% of the sample results for
cucumber and summer squash were below the LOQ, MLE procedures were not
needed to impute censored values. However, because 15% of the cantaloupe
results were below the LOQ, the MLE procedure was used to impute
censored values.

The datasets for cantaloupe, cucumber and summer squash were entered
into the tolerance spreadsheet.  Visual inspection of the lognormal
probability plots (Figures II-17a, II-18a and II-19) provided in the
spreadsheet indicate that the datasets are each reasonably lognormal.
The results from the approximate Shapiro-Francia test statistic (Figures
II-17b, II-18b and II-20) confirmed that the assumption of lognormality
should not be rejected.

Using the tolerance spreadsheet, the recommended tolerances were 0.08
ppm each for cucumber and summer squash.  The maximum observed residue
value for cantaloupe was 0.258 ppm.  Because these values differ by less
than 5x, a crop group tolerance is appropriate for cucurbit vegetable.
The petitioner has proposed a tolerance of 0.4 ppm; the available data
indicate that 0.50 ppm is an appropriate value for the tolerance.

Table II-3.	Residue data used to calculate tolerance for fluopicolide on
the cucurbit vegetable crop group.

Regulator:	EPA	EPA	EPA

Chemical:	Fluopicolide	Fluopicolide	Fluopicolide

Crop:	Cantaloupe	Cucumber	Summer squash

PHI:	2 days	2 days	2 days

App. Rate:	3 at 0.119 lb ai/A/application	3 at 0.119 lb ai/A/application
3 at 0.119 lb ai/A/application

Submitter:	Valent U.S.A.	Valent U.S.A.	Valent U.S.A.

MRID Citation:	46708531	46708532	46708538

	Residues of Fluopicolide (ppm)

	0.043	0.016	0.039

	0.069	0.031	0.051

	0.053	0.013	0.014

	0.048	<0.01	0.014

	0.066	0.016	0.017

	0.040	0.011	0.027

	0.030	0.024	0.034

	0.060	0.029	0.042

	<0.01	0.028	0.040

	<0.01	0.015	0.035

	0.040	0.057	0.019

	0.057	0.043	0.030

	0.080

	0.098

	0.104

	0.258

	<0.01

	0.163

Figure II- 17a.  Lognormal probability plot of fluopicolide field trial
data for cantaloupe.

Figure II- 17b.   Tolerance spreadsheet summary of fluopicolide field
trial data for cantaloupe.

Figure II- 18a.  Lognormal probability plot of fluopicolide field trial
data for cucumber.

Figure II- 18b.   Tolerance spreadsheet summary of fluopicolide field
trial data for cucumber.

Figure II- 19.  Lognormal probability plot of fluopicolide field trial
data for summer squash.

Figure II- 20.   Tolerance spreadsheet summary of fluopicolide field
trial data for summer squash.

Grape

The dataset used to establish a tolerance for fluopicolide on grape
consisted of field trial data representing application rates of 0.36 lb
ai/A (3 applications at 0.119 lb ai/A/application) with a 20- to 21-day
PHI.  As specified by the Guidance for Setting Pesticide Tolerances
Based on Field Trial Data SOP, the field trial application rates and
PHIs are within 25% of the maximum label application rate and minimum
label PHI, respectively.  The residue values used to calculate the
tolerance are provided in Table II-4.

All field trial sample results were above the LOQ and the dataset was
large (32 samples).

The dataset was entered into the tolerance spreadsheet.  Visual
inspection of the lognormal probability plot (Figure II-21) provided in
the spreadsheet indicate that the dataset was reasonably lognormal.  The
results from the approximate Shapiro-Francia test statistic (Figure
II-22) confirmed that the assumption of lognormality should not be
rejected.

Using the tolerance spreadsheet, the recommended tolerance for grape was
1.4 ppm.  HED has recently recommended for a tolerance for fluopicolide
residues in grape at 2.0 ppm, in support of use on imported grapes.  The
available domestic crop field trial data for grape indicate that the
recommended tolerance of 2.0 ppm is appropriate.

Table II-4.	Residue data used to calculate tolerance for fluopicolide on
grape.

Regulator:	EPA

Chemical:	Fluopicolide

Crop:	Grape (domestic)

PHI:	20-21 days

App. Rate:	3 at 0.119 lb ai/A/application

Submitter:	Valent U.S.A.

MRID Citation:	46708541

	Residues of Fluopicolide (ppm)

	0.440	0.100

	0.320	0.077

	0.070	0.120

	0.065	0.130

	0.260	0.093

	0.210	0.098

	0.220	0.980

	0.320	0.990

	0.250	0.850

	0.220	1.100

	0.560	0.190

	0.320	0.150

	0.100	0.140

	0.130	0.130

	0.180	0.430

	0.210	0.530

Figure II-21.  Lognormal probability plot of fluopicolide field trial
data for grape.

Figure II- 22.   Tolerance spreadsheet summary of fluopicolide field
trial data for grape.

Rotated wheat commodities

The dataset used to establish a tolerance for fluopicolide on rotated
wheat forage, hay, and straw consisted of extensive field rotational
crop data for wheat; fluopicolide was applied to a primary crop at
~0.36 lb ai/A (3 applications at ~0.119 lb ai/A/application) and wheat
was planted 29-37 days after last application.  As specified by the
Guidance for Setting Pesticide Tolerances Based on Field Trial Data SOP,
the field trial application rates and plantback intervals (PBIs) are
within 25% of the maximum label application rate and proposed label PBI,
respectively.  The residue values used to calculate the tolerance are
provided in Table II-5.

All field trial sample results, with the exception of one wheat forage
result and four wheat straw results, were above the LOQ, and each
dataset was large (42 samples).

The dataset for each crop was entered into the tolerance spreadsheet.
The results from the approximate Shapiro-Francia test statistic (Figures
II-24, II-26, and II-28) indicate that the assumption of lognormality
should be rejected for each crop, and visual inspection of the lognormal
probability plots (Figures II-23, II-25, and II-27) confirmed that the
datasets are not lognormal.

Using the tolerance spreadsheet, the recommended tolerances were 0.20
ppm for wheat forage, 0.50 ppm for wheat hay, and 0.30 ppm for wheat
straw.  The recommended tolerances for wheat forage and hay are
appropriate.  However, method validation data for residues of
fluopicolide in/on wheat straw indicated marginally adequate
performance, with recoveries ranging 61.5-75.5%.  These low recoveries,
in combination with the 0.30-ppm tolerance calculated by the tolerance
spreadsheet, indicate that the proposed tolerance of 0.50 ppm for wheat
straw is appropriate.

Table II-5.	Residue data used to calculate tolerances for fluopicolide
on rotated wheat forage, hay, and straw.

Regulator:	EPA	EPA	EPA

Chemical:	Fluopicolide	Fluopicolide	Fluopicolide

Crop:	Rotated wheat forage	Rotated wheat hay	Rotated wheat straw

PBI:	29-37 days	29-37 days	29-37 days

App. Rate:	3 at 0.119 lb ai/A/application	3 at 0.119 lb ai/A/application
3 at 0.119 lb ai/A/application

Submitter:	Valent U.S.A.	Valent U.S.A.	Valent U.S.A.

MRID Citation:	46708547	46708547	46708547

	Residues of Fluopicolide (ppm)

	0.027	0.046	0.030

	0.023	0.039	0.036

	0.017	0.057	0.046

	0.012	0.039	0.055

	0.013	0.041	0.023

	0.015	0.032	0.023

	0.018	0.059	0.018

	0.019	0.063	0.016

	0.015	0.029	0.010

	0.013	0.030	0.011

	0.039	0.056	0.038

	0.038	0.060	0.029

	0.028	0.037	0.030

	0.022	0.040	0.034

	0.026	0.071	0.036

	0.021	0.071	0.050

	0.049	0.045	0.037

	0.013	0.033	0.059

	0.033	0.057	0.017

	0.031	0.037	0.025

	0.050	0.030	0.024

	0.047	0.021	0.021

	0.022	0.020	<0.01

	0.022	0.023	<0.01

	0.014	0.014	<0.01

	0.015	0.021	<0.01

	0.025	0.056	0.014

	0.022	0.034	0.013

	0.047	0.030	0.044

	0.042	0.077	0.034

	0.189	0.501	0.326

	0.121	0.043	0.350

	0.028	0.397	0.054

	0.015	0.331	0.046

	0.039	0.344	0.188

	0.051	0.290	0.181

	0.060	0.089	0.040

	<0.01	0.077	0.042

	0.141	0.184	0.020

	0.115	0.307	0.036

	0.106	0.147	0.117

	0.213	0.224	0.102

Figure II- 23.  Lognormal probability plot of fluopicolide rotational
crop trial data for wheat forage.

Figure II- 24.   Tolerance spreadsheet summary of fluopicolide
rotational crop trial data for wheat forage.

Figure II- 25.  Lognormal probability plot of fluopicolide rotational
crop trial data for wheat hay.

Figure II- 26.   Tolerance spreadsheet summary of fluopicolide
rotational crop trial data for wheat hay.

Figure II- 27.  Lognormal probability plot of fluopicolide rotational
crop trial data for wheat straw.

Figure II- 28.   Tolerance spreadsheet summary of fluopicolide
rotational crop trial data for wheat straw.

Appendix III.  Proposed Metabolic Pathway for Fluopicolide in
Rotational Crops.

Fluopicolide	Summary of Analytical Chemistry and Residue Data	DP 339155

 PAGE

Page   PAGE  1  of   NUMPAGES  102

Fluopicolide	Summary of Analytical Chemistry and Residue Data	DP 339155

Page   PAGE  25  of   NUMPAGES  102


[Federal Register Volume 82, Number 23 (Monday, February 6, 2017)]
[Notices]
[Page 9376]
[FR Doc No: 2017-02422]

-----------------------------------------------------------------------

DEPARTMENT OF ENERGY

Federal Energy Regulatory Commission

[Docket No. EL17-39-000]

CPV Maryland, LLC; Notice of Institution of Section 206
Proceeding and Refund Effective Date

    On January 30, 2017, the Commission issued an order in Docket No.
EL17-39-000, pursuant to section 206 of the Federal Power Act (FPA), 16
U.S.C. 824e (2012), instituting an investigation into whether the Rate
Schedule for Reactive Service of CPV Maryland, LLC may be unjust,
unreasonable, unduly discriminatory or preferential. CPV Maryland, LLC,
158 FERC 61,084 (2017).
    The refund effective date in Docket No. EL17-39-000, established
pursuant to section 206(b) of the FPA, will be the date of publication
of this notice in the Federal Register.
    Any interested person desiring to be heard in Docket No. EL17-39-
000 must file a notice of intervention or motion to intervene, as
appropriate, with the Federal Energy Regulatory Commission, 888 First
Street NE., Washington, DC 20426, in accordance with Rule 214 of the
Commission's Rules of Practice and Procedure, 18 CFR 385.214, within 21
days of the date of issuance of the order.

    Dated: January 31, 2017.
Kimberly D. Bose,
Secretary.
[FR Doc. 2017-02422 Filed 2-3-17; 8:45 am]
 BILLING CODE 6717-01-P