Assumptions   The percent active ingredient in solution was selected from the label 507 3, which states that a 0.0017 lb ai/ gal solution should be used ( 0.0201% ai solution).   The film thickness for a hand sanitizing solution could not be located. Therefore, the film thickness used in this assessment is 5.94 mg/ cm2, which is from the document titled, " Method for Estimating Retention of Liquids on Hands." ( Bryan, 1988). The film thickness is from a scenario in which both hands are immersed in bath oil and remain wet. The film thickness for bath oil was chosen over the other available film thicknesses for mineral oil ( 10.3 mg/ cm2) and cooking oil ( 6.02 mg/ cm2) because bath oil is the most water soluble and the least viscous ( i. e. most similar to the hand sanitizing solution). Additionally, the full hand immersion scenario, without wiping, was chosen because the dermal endpoint for short term durations is based on dermal irritation effects.

Results Table 6.3 shows the calculation of the dermal risk for hand sanitization. The dermal MOE is above the target MOE of 100.

Table 6.3. Short Term Dermal Risks Associated With Hand Sanitizing % ai in Film thickness Surface Residue on Hands a Page 50 of 107 Exposure Scenario solution ( mg/ cm2) ( µ g/ cm2) Dermal MOE b ( Target MOE = 100) b Hand Sanitizer 0.0201% 5.94 1.19 280 a Surface Residue on Hands ( µ g/ cm2) = % ai in solution x film thickness on hands ( mg/ cm2) x conversion factor ( 1,000 µ g/ mg). b MOE = NOAEL ( µ g/ cm2) / Surface residue on hands ( µ g/ cm2) [ Where: short term dermal NOAEL = 333 µ g/ cm2, Table 3.2]. Target MOE = 100.

6.2.2 Fogging ( Food Processing Plant and Hatchery)

Post application inhalation exposures only were assessed for entry into a building ( hatchery and food processing plant) after a fogging application, because dermal post application is presumed to be negligible. The inhalation exposure assessment was conducted using the Multi Chamber Concentration and Exposure Model ( MCCEM v1.2). MCCEM estimates average and peak indoor air concentrations of chemicals released from products or materials in houses, apartments, townhouses, or other residences. Although the data libraries contained in MCCEM are limited to residential settings, the model can be used to assess other indoor environments. MCCEM has the capability to estimate inhalation exposures to chemicals, calculated as single day doses, chronic average daily doses, or lifetime average daily doses. ( All dose estimates are potential doses; they do not account for actual absorption into the body.)

The product, EPA Reg # 10324 118 ( 21.7% ai) with a maximum application rate of 0.011 lb ai/ gal, was assessed for fogging use in a food processing plant. The label states to fog one quart of the diluted product per 1,000 cubic feet. All labels which can be used for fogging in food processing areas indicate that all personnel must vacate the room during fogging and for a minimum of 2 hours after fogging. Therefore, exposure was calculated for a person entering the food processing plant 2 hours after all the applied fogger has been deployed.

The product, EPA Reg # 10324 118 ( 21.7% ai) with a maximum application rate of 0.27 lb ai/ gal, was assessed for fogging use in hatcheries and incubators. After fogging, the label states that the building should be well ventilated, but does not indicate that personnel should vacate the room. The only label with agricultural fogging uses which indicates that personnel should vacate the room after fogging is EPA Reg# 10324 111 ( maximum application rate of 0.192 lb ai/ gal). This label states to " well" ventilate the room after fogging and not to enter until 2 hours after fogging. Therefore, exposure was calculated for a person entering the building immediately after all the applied fogger has been deployed and 2 hours after all the applied fogger has been deployed Assumptions used to calculate inputs for MCCEM and the calculated exposure values are presented in Table 6.4 for food processing plants and in Table 6.5 for hatcheries. The following assumptions were made:

  The area being fogged is a one chamber barn with dimensions of 300 ft x 50 ft x10 ft ( AD standard assumption).   For the food processing plant, the air exchange rate is 0.18 per hour ( MCCEM default based on a residential home). For a hatchery, the air exchange rate is 4 per hour based on the rate for a poultry barn ( Jacobson, 2005). Page 51 of 107   Fogging occurs instantaneously, so that the entire mass of product is mixed homogeneously with the indoor air as soon as fogging commences.   It is assumed that all of the aerosols are inhalable and/ or respirable.

Table 6.4. Short and Intermediate Term Inhalation Risks Associated with Post application Exposure to ADBAC After Fogging a Food Processing Plant Parametera Value Rationale Dimensions 300x50x10 ft, 15,000 ft2 floor area, 150,000 ft3 ( 4,248 m3) volume EPA Assumption Air Changes per Hour ( ACH)* 0.18/ hr EPA Assumption Activity Pattern* 8 hour Time Weight Average ( TWA) starting at expiration of 2 hr REI Based on product =

s re entry interval ( 10324 118) Concentration of Fogging Liquid 0.011 lb ai/ gal Product Label ( See Table 6.1) Use rate 1 quart/ 1,000 ft3 Product label Amount applied to room 0.0441 g ai/ m3 ( Use rate) x ( Concentration) Concentration in room after fogging ( initial concentration rate at time 0)* 44 mg/ m3 Mass / Volume Body Weight 60 kg EPA Assumption Inhalation Rate 1.0 m3/ hr NAFTA Light Activity for Adults ( USEPA, 1997) MCCEM Output Average Concentration over 8 hrs ( mg/ m3) 2 hr re entry: 16.65 Average of MCCEM calculated air concentrations from Hour 2 to Hour 10 for 2 hr REI 8 hr Dose ( mg/ kg/ day) 2 hr re entry: 2.22 Average Conc. * 8 hrs * Inhal. Rate / BW 8 hr short term MOE 2 hr re entry: 1 NOAEL ( 3 mg/ kg/ day) / Dose * Used as MCCEM input. Default values from MCCEM were used for all inputs not listed in the table above Table 6.5. Short and Intermediate Term Inhalation Risks Associated with Post application Exposure to ADBAC After Fogging a Hatchery Parameter Value Rationale Barn Dimensions* 300x50x10 ft, 15,000 ft2 floor area, 150,000 ft3 ( 4,248 m3) volume EPA Assumption Air Changes per Hour ( ACH)* 4/ hr Jacobson, 2005 Activity Pattern* 8 hour Time Weight Average ( TWA) starting at expiration of 0 hr re entry interval and 2 hr re entry interval Based on product =

s re entry interval ( EPA Registration No. 10324 118 and 10324 111). Concentration of Fogging Liquid 21.7% a. i. Product Label ( See Table 6.1)

Use rate 0.42 gal/ 4,000 ft3 Product label states to fog 1 min/ 4,000 ft3. Output of 0.42 gal/ min from http:// bugsource. com/ mistermax. html Mass applied to barn 0.394 g ai/ m3 ( Use rate) x ( Concentration) Concentration in barn after fogging ( initial concentration rate at time 0)* 381 mg/ m3 Mass / Volume Body Weight 60 kg EPA Assumption Inhalation Rate 1.0 m3/ hr NAFTA Light Activity for Adults ( USEPA, 1997) Page 52 of 107 Table 6.5. Short and Intermediate Term Inhalation Risks Associated with Post application Exposure to ADBAC After Fogging a Hatchery Parameter Value Rationale MCCEM Output Average Concentration over 8 hrs ( mg/ m3) 0 hr Re entry: 44.6 2 hr Re entry: 0.01496 Average of MCCEM calculated air concentrations from Hour 0 to Hour 8 for 0 hr re entry and Hour 2 to Hour 10 for 2 hr re entry 8 hr Dose ( mg/ kg/ day) 0 hr Re entry: 5.95 2 hr Re entry: 0.001995 Average Conc. * 8 hrs * Inhal. Rate / BW 8 hr short term MOE 0 hr Re entry: 0.50 2 hr Re entry: 1,500 NOAEL ( 3 mg/ kg/ day) / Dose A detailed report is presented in Appendix D, including hourly air concentrations. Based on MCCEM output, 8 hr MOE values were calculated. The MOE for fogging in the food processing plant ( 2 hr re entry interval) was below the target MOE of 100. For fogging in hatcheries, the 8 hr MOE was below the target MOE of 100 immediately after fogging and was above the target MOE of 100 2 hours after fogging. The risks of concern for the food processing plant are attributed to the low air changes per hour assumed ( i. e., 0.18 ACH) in the assessment. For the poultry barn, ventilation rate was obtained from Jacobson ( 2005). The assessment for food processing plants could be refined if a more accurate ventilation rate could be obtained.

6.3 Wood Preservation ADBAC is used in products that are intended to preserve wood through both nonpressure treatment methods and pressure treatment methods. It is also intended for use on existing homes ( wood shingles or shake roofs and siding) by spray or brush.

The exposure scenarios assessed in this document for the representative wood preservation uses selected by AD are shown in Table 6.1. Section 6.3.1 presents the exposure analysis for the handler and post application scenarios for non pressure treatment scenarios and Section 6.3.2 presents the exposure analysis for the handler and post application scenarios for pressure treatment scenarios.

Dermal irritation exposures from post application activities in the wood preservation treatment facility will be mitigated using default personal protective equipment requirements based on the toxicity of the end use product. Therefore, only inhalation exposures and risks are presented.

6.3.1 Non Pressure Treatment Scenarios ( Handler and Post application)

<IP_ADDRESS> Scenarios Assessed by Worker Function Page 53 of 107 The proprietary study, " Measurement and Assessment of Dermal and Inhalation Exposures to Didecyl Dimethyl Ammonium Chloride ( DDAC) Used in the Protection of Cut Lumber ( Phase III)" ( Bestari et al., 1999, MRID 455243 04) identified various worker functions/ positions for individuals that handle DDAC containing wood preservatives for nonpressure treatment application methods and for individuals that could then come into contact with the preserved wood. The worker functions/ positions identified in the DDAC study are presented below. It was assumed that similar tasks are performed when handling ADBAC products and ADBAC treated wood, therefore, these same functions were assessed for ADBAC.

Handler:   Blender/ spray operators are workers that add the wood preservative into a blender/ sprayer system for composite wood via closed liquid pumping.   Diptank Operators can be in reference to wood being lowered into the treating solution through an automated process ( i. e., elevator diptank, forklift diptank). This scenario can also occur in a smaller scale treatment facility in which the worker can manually dip the wood into the treatment solution.   Chemical operators for a spray box system consist of chemical operators, chemical assistants, chemical supervisors, and chemical captains. These individuals maintain a chemical supply balance along with flushing and cleaning spray nozzles.

Post application:   Graders, positioned right after the spray box, grade dry lumber by hand ( i. e. detect faults). In the DDAC study, graders graded wet lumber; therefore, the exposures to graders using ADBAC are worst case scenarios.   Millwrights repair all conveyer chains and general up keep of the mill.   Clean up crews perform general cleaning duties at the mill.   Trim saw operators operate the hula trim saw and consist of operators and strappers. In the DDAC study, hula trim saw operators handled dry lumber.   Construction workers install treated plywood, oriented strand board, medium density fiberboard, and others.

As very little chemical specific data were available regarding typical exposures to ADBAC as a wood preservative, surrogate data were used to estimate exposure risks. The blender/ spray operator position was assessed using CMA unit exposure data and the remaining handler and post application positions were assessed using data from the DDAC study ( Bestari et al., 1999). This study is proprietary; therefore, data compensation needs to be addressed for use of these data in this exposure assessment.

Blender/ Spray Operators The inhalation exposures and risks to the composite wood blender/ spray operators were assessed using Equations 1 through 3 in Section 1.2. The surrogate unit exposures were taken from the CMA study ( USEPA, 1999). Specifically, the liquid pump preservative unit exposures for gloved workers were used in this assessment. The unit exposure is 0.000403 mg/ lb ai. This value is based on two replicates. The quantity of the wood being treated was derived from other wood preservative estimates ( USEPA, 2004) for the amount of wood slurry treated because no chemical specific data were available for ADBAC. It was assumed Page 54 of 107 that batches of wood slurry are treated in 10,000 gallon tanks, and that eight batches of wood slurry are treated per day ( one per hour for an 8 hr work shift). Additionally, it was assumed that each batch requires 3,000 gallons of preservatives and the remainder volume of the tank consists of wood slurry ( 7,000 gallons of wood slurry per batch). Since wood chips have a density of approximately 380 kg/ m3 ( SIMetric, 2005), the total amount of wood slurry treated per day would be 178,000 lbs ( 8 batches/ day x 7,000 gallons/ batch x 0.003785 m3/ gallon x 380 kg/ m3 x 2.2 lb/ kg). The assumptions used for batch sizes and the quantity of preservative needed are consistent with an assessment performed previously by the EPA ( USEPA, 2003). The ADBAC assessment was conducted using an application rate of 3% ai solution.

Table 6.6 provides the inhalation doses and MOEs for the workers adding the preservative to the wood slurry. The inhalation MOE is below the target MOE of 100 for short, intermediate, and long term inhalation exposures ( MOE = 84).

Table 6.6. Short, Intermediate, and Long Term Inhalation Exposures and MOEs for Blender/ Spray Operator Exposure Scenario Inhalation Unit Exposurea ( mg/ lb ai) Application Rate (% ai in solution/

day) Wood Slurry Treatedb ( lb/ day) Daily Dosec ( mg/ kg/ day) ST/ IT/ LT MOEd ( Target MOE = 100) Occupational Handler Blender/ spray operator 0.000403 3 178,000 0.036 84 ST = Short term duration; IT = Intermediate term duration; and LT = long term. a. Inhalation unit exposure: Baseline. b. Wood slurry treated = ( 8 batches/ day x 7,000 gallons/ batch x 0.003785 m3/ gallon x 380 kg/ m3 x 2.2 lb/ kg) c. Daily Dose = unit exposure ( mg/ lb ai) x App Rate (% ai/ day) x Quantity treated ( lb/ day) x absorption factor ( 100% for inhalation) / BW ( 60 kg) d. MOE = NOAEL ( mg/ kg/ day)/ Daily dose [ Where ST/ IT/ LT NOAEL = 3 mg/ kg/ day for inhalation. Target MOE = 100.

Chemical Operators, Graders, Millwrights, Clean up Crews, and Trim Saw Operators The inhalation exposures to chemical operators, graders, millwrights, trim saw operators, and clean up crews were assessed using surrogate data from the DDAC study ( Bestari et al., 1999). The DDAC study examined individuals =

exposure to DDAC while working with antisapstains and performing routine tasks at 11 sawmills/ planar mills in Canada. Dermal and inhalation exposure monitoring data were gathered for each job function of interest using dosimeters and personal sampling tubes. Dosimeters and personal air sampling tubes were analyzed for DDAC. Exposure data for individuals performing the same job functions were averaged together to determine job specific averages. Monitoring was conducted using 2 trim saw workers, 13 grader workers, 11 chemical operators, 3 millwrights, and 6 clean up staff.

The individual inhalation exposures from the DDAC study are presented in Table E 1 in Appendix E. To determine ADBAC exposures, the average DDAC exposures measured on individuals ( in terms of total mg DDAC) were multiplied by a modification factor of 0.625 to account for the difference in percent active ingredient between ADBAC and DDAC ( 50% ADBAC in the wood preservative product versus 80% DDAC in the comparative wood preservative product). The lb ai handled by each person or the % ai in the treatment solution were not provided for these worker functions. Page 55 of 107 The following equation was used to calculate daily dose for ADBAC:

Daily Dose = DDAC UE x CR x AB ( Eq. 12) BW Where:

DDAC UE = DDAC surrogate dermal or inhalation unit exposure ( mg/ day); CR = Conversion ratio ( 50% ADBAC / 80% DDAC); AB = Absorption factor ( 100% for inhalation); and BW = Body weight ( 60 kg).

In using this methodology, the following assumptions were made:

  DDAC and ADBAC end use products will be used in similar quantities.

  The procedures for applying both chemicals are similar.

  The limits of detections ( LOD) for inhalation residues from chemical operators, graders, mill wrights, and clean up staff replicates were not provided in the DDAC report. For lack of better data, it was assumed that the inhalation LODs for these worker positions are equal to the LOD of the diptank operator replicates ( 5.6 µ g). For all measurements below the air concentration associated with this detection limit, half the detection limit was used.

  Air concentrations were reported in the DDAC study. To convert air concentrations ( µ g/ m3) into terms of inhalation unit exposure ( mg/ day), the air concentrations were multiplied by an inhalation rate of 1.0 m3/ hr for light activity ( USEPA, 1997), a sample duration of 8 hrs/ day, and a conversion factor of 1 mg/ 1000 µ g. Table D 1 in Appendix D presents the inhalation and dermal DDAC exposures.

  Average DDAC dermal and inhalation exposures were multiplied by a conversion ratio of 0.625 to account for the differences in ADBAC and DDAC concentrations [( 50% ADBAC / 80% DDAC)].

Table 6.7 provides the short, intermediate, and long term inhalation doses and MOEs for chemical operators, graders, millwrights, clean up crews, and trim saw operators. The inhalation MOEs are above the target MOE of 100 for all worker functions. Any dermal irritation exposures from post application activities will be mitigated using default personal protective equipment requirements based on the toxicity of the end use product.

It should be noted that although the target inhalation MOE is 100, the MOE for the clean crew workers is below 1,000; therefore, the Agency may request a confirmatory inhalation toxicity study.

  Wood Preservation ( non pressure treatment), clean up crew: ST/ IT/ LT Inhalation MOE = 480 Page 56 of 107 Table 6.7. Short, Intermediate, and Long Term Inhalation Exposures and MOEs for Wood Preservative Chemical Operators, Graders, Trim Saw Operators, and Clean Up Crews ( Handler and Post application Activities)

Exposure Scenarioa ( number of volunteers) Inhalation UEb ( mg/ day) Conversion Ratioc Daily Dosed ( mg/ kg/ day) MOEe ( Target MOE = 100)

Occupational Handlers Chemical Operator ( n= 11) 0.0281 0.625 0.000292 10,000 Occupational Post Application Grader ( n= 13) 0.0295 0.625 0.000307 9,800 Trim Saw ( n= 2) 0.061 0.625 0.00063 4,800 Millwright ( n= 3) 0.057 0.625 0.00059 5,100 Clean Up ( n= 6) 0.60 0.625 0.0063 480 ST = Short term duration, IT = Intermediate term duration, LT = Long term duration a. The exposure scenario represents a worker wearing short sleeved shirts, cotton work trousers, and cotton glove dosimeter gloves under chemical resistant gloves. Volunteers were grouped according to tasks they conducted at the mill. b. Inhalation unit exposures are from Bestari et. al. ( 1999). Refer to Table E 1 in Appendix E for the calculation of the dermal and inhalation exposures. Inhalation exposure ( mg/ day) was calculated using the following equation: Air concentration ( µ g/ m3) x Inhalation rate ( 1.0 m3/ hr) x Sample duration ( 8 hr/ day) x Unit conversion ( 1 mg/ 1000 µ g). The inhalation rate is from USEPA, 1997. c. Conversion Ratio = 50% ADBAC / 80% DDAC d. Daily dose ( mg/ kg/ day) = exposure ( mg/ day) x conversion ratio ( 0.625) x absorption factor ( 100% for inhalation)/ body weight ( 60 kg). e. MOE = NOAEL ( mg/ kg/ day)/ Daily dose [ Where inhalation NOAEL = 3 mg/ kg/ day]. Target MOE = 100.

Diptank Operators Exposures to diptank operators were also assessed using surrogate data from the DDAC study ( Bestari et al., 1999). The diptank scenario assessment was conducted differently than for the other job functions because the concentration of DDAC in the diptank solution was provided. The exposure data for diptank operators were converted into A unit exposures @

in terms of mg a. i. for each 1% of concentration of the product. The calculation of the inhalation unit exposure ( 0.046 mg/ 1% solution) is presented in Table E 2 in Appendix E. The air concentrations presented in the DDAC study were converted to unit exposures using an inhalation rate of 1.0 m3/ hr ( light activity) ( USEPA, 1997) and a sample duration of 8 hrs/ day.

The following equations are used to estimate inhalation handler exposure:

Daily Dose = DDAC UE x AI x AB ( Eq. 13) BW Where:

DDAC UE = DDAC inhalation unit exposure ( mg/ 1% in solution); AI = Percent active ingredient ( 3% ai in solution/ day); AB = Absorption factor ( 100% for inhalation); and BW = Body weight ( 60 kg). Page 57 of 107 Table 6.8 provides the short, intermediate and long term inhalation dose and MOEs for diptank operators. The inhalation MOE is above the target MOE of 100 and, therefore, is not of concern.

Table 6.8. Short, Intermediate, and Long Term Inhalation Exposures and MOEs for Diptank Operator ( Handler Activity)

Exposure Scenarioa ( number of replicates) Inhalation Unit Exposureb ( mg DDAC/ 1% solution) App Rate (% a. i. in solution/ day) Daily Dosec ( mg/ kg/ day) MOEd Occupational Handler Dipping, with gloves ( n= 7) 0.046 3 0.0023 1,300 a The exposure scenario represents a worker not wearing a respirator. b Inhalation unit exposures are from DDAC study ( MRID 455243 04). Refer to Table E 2 in Appendix E for the inhalation unit exposure calculations. Inhalation exposure ( mg) was calculated using the following equation: Air concentration ( mg/ m3) x Inhalation rate ( 1.0 m3/ hr) x Sample Duration ( 8 hr). The inhalation rate is from USEPA, 1997. c Daily dose ( mg/ kg/ day) = unit exposure ( mg/ 1% ai solution) x percent active ingredient in solution ( 3% ai) x absorption factor ( 100% for inhalation) / body weight ( 60 kg). d MOE = NOAEL ( mg/ kg/ day) / Daily dose [ Where inhalation NOAEL = 3 mg/ kg/ day. Target MOE = 100.

Construction workers Potential risks resulting from construction worker dermal contact with ADBACtreated wood are assessed in the same manner as potential risks resulting from children's dermal contact with ADBAC treated play sets and decks ( Section <IP_ADDRESS>). The risks were calculated using average and maximum worker residue data for hands available in the DDAC study. Hand residue data from the end stacker, stickman, and tallyman workers were used because of the possibility of the contact with dry treated wood. The maximum and average values of these data ( 3.0 and 1.4 : g/ cm2) were assumed to be the dermal exposure. As shown in Table 4.8, the dermal MOEs for the maximum and average hand residues are 110 and 240, respectively, which are above the target MOE of 100.

<IP_ADDRESS> Scenarios Assessed for Exposure from Applications to Existing Homes ( Handler)

Applications to wood roofs, shingles, and siding of existing homes can be made by brush and spray methods. The airless spray method was assessed because it represents highend exposure. Handler exposures were assessed using Equations 1 through 3 in Section 1.2. The inhalation unit exposure value was taken from PHED ( 0.83 mg/ lb a. i.) and the amount of treatment solution used was assumed to be 50 gallons ( EPA/ AD assumption for painting).

The calculated inhalation MOE is shown in Table 6.9 for all durations of exposure. The MOE is below the target MOE of 100 ( MOE = 17).

Table 6.9. Short, Intermediate, and Long Term Inhalation Exposures and MOEs for Spray and Brush Preservative Treatment to Exterior of Existing Homes Page 58 of 107 Exposure Site Application Equipment App. Rate ( lb ai/ dilute gallon) Quantity Handled/ Treated per day ( gallons) Baseline Inhalation Unit Exposure ( mg/ lb ai) Daily Dosesa ( mg/ kg/ day) MOEb ( Target MOE = 100)

Exterior of Existing Homes Airless Spray 0.25 50 0.83 10 17 a Daily dose ( mg/ kg/ day) = unit exposure ( mg/ lb ai) x quantity handled ( gallons) x absorption factor ( 100% for inhalation) / body weight ( 60 kg). b MOE = NOAEL ( mg/ kg/ day) / Daily dose [ Where inhalation NOAEL = 3 mg/ kg/ day for all durations]. Target MOE = 100.

6.3.2 Pressure Treatment Scenarios ( Handler and Post Application)

ADBAC may be used to treat wood and wood products using pressurized application methods such as double vacuum. According to the product labels, the maximum retention rate is 0.6 lb/ ft3. An application rate was not provided on the product labels; therefore, an application rate of 3% ai solution was used in this assessment, based on the master label. ADBAC specific exposure data are not available for assessment of pressure treatment exposure. Therefore, the assessment relies on surrogate chromated copper arsenate ( CCA) data ( ACC, 2002b) and was based on the approach used in a previous exposure assessment ( USEPA, 2003).

Surrogate Unit Exposure Data Dermal and inhalation exposures for pressure treatment uses are derived from information in the exposure study by the American Chemistry Council ( 2002) entitled " Assessment of Potential Inhalation and Dermal Exposure Associated with Pressure Treatment of Wood with Arsenical Wood Products" ( ACC, 2002b). In this study, a treatment solution of CCA was approximately 0.5 percent. The CCA study is the best pressure treatment data available for a water based solution to estimate exposure to ADBAC.

The CCA study measured both handlers and post application activities. Although there is overlap in job functions, the handlers are defined as being either treating operators ( TOs) or treating assistants ( TAs). The TOs were monitored at three sites ( A, B, and C) using 5 replicates at each site. The TAs were monitored at two sites ( Sites A and C) using 5 replicates at each site. The post application activities included: tram setter ( TS) at Site A ( n= 5); stacker operator ( SO) at Site A ( n= 4); loader operator ( LO) at Sites A, B, C ( n= 15); supervisor ( S) at Site B ( n= 5); test borer ( TB) at Site C ( n= 5); and the tallyman ( TM) at Site C ( n= 5). According to the CCA study, workers wore cotton long sleeved shirts and cotton trousers ( or one piece cotton coveralls) over the whole body dosimeters (" plus additional shirts or jackets per typical practice at Site B") and chemical resistant or work gloves, when appropriate. Therefore, the CCA study provides exposure data associated with maximum PPE ( excluding respirators). In using the CCA study for this ADBAC assessment, the TO and TA handlers are assessed separately. The post application job functions, however, have been combined into one data set to represent post application activities because for most activities the sample size is small ( 5   n   15). Page 59 of 107 The measured CCA inhalation exposure values were normalized by the treatment solution concentration used at each of the 3 facilities ( i. e., unit exposure reported as µ g arsenic/ ppm treatment solution). The normalization by treatment solution concentration was performed to extrapolate the measured exposures in the CCA study ( monitored at ~ 0.5% ai solution) to the maximum ADBAC treatment solution concentration ( 1% ai solution). Table 6.10 presents the inhalation unit exposure values normalized to the treatment solution concentration in ppm for ( 1) all sites, ( 2) treatment operator ( TA handler), ( 3) treatment assistant ( TA handler), and ( 4) all post application job functions ( TS, SO, LO, S, TB, TM).

Exposure Calculations The following equation was used to estimate inhalation handler exposure:

Daily Dose = UE x AI x AB ( Eq. 14) BW Where:

UE = Unit exposure ( mg As/ ppm); AI = Percent active ingredient ( 3% ai in solution); AB = Absorption factor ( 100% inhalation); and BW = Body weight ( 60 kg).

Results The estimated inhalation exposures and risks for ADBAC are presented in Table 6.11. The calculated inhalation MOEs are above the target MOE of 100 for all scenarios.

Table 6.10. Inhalation Exposure Values from a CCA Pressure Treatment Study ( Exposure Data used as Surrogate Unit Exposures for ADBAC Assessment)

Treatment Solution Site % ppma Statistic Air Concentrationb ( µ g As/ m3/ ppm) Inhalation Unit Exposurec ( µ g As/ ppm)

Average ± std 0.00013 ± 0.00023 0.00104 Median 0.00013 0.00104 90th percentile 0.00077 0.00617 All sites  All Data ( n = 64) 0.438 to 0.595 4,380 to 5,950 Maximum 0.0011 0.00882 Average ± std 0.00032 ± 0.00038 0.00257 Median 0.00013 0.00104 90th percentile 0.00092 0.00737 All sites  Handler Treatment Operator ( n = 15) 0.438 to 0.595 4,380 to 5,950 Maximum 0.0011 0.00882 Average ± std 0.0001 ± 0.00004 0.000802 Median 0.00013 0.00104 90th percentile 0.00013 0.00104 All sites  Handler Treatment Assistant ( n = 10) 0.438 to 0.595 4,380 to 5,950 Maximum 0.00014 0.00112 Average ± std 0.00020 ± 0.00025 0.00160 Median 0.00013 0.00104 90th percentile 0.00050 0.00401 All sites   Postapplication All job functions ( TS, SO, LO, S, TB, TM) ( n = 39)

Maximum 0.0011 0.00882 Page 60 of 107 a. ppm = (% treatment solution) * ( 10,000). b. Air concentration was calculated as µ g collected per sample per ppm / ( 480 min per day x 2 L/ min). c. Inhalation unit exposure = air concentration ( µ g As/ m3/ ppm) x breathing rate for light activities ( 0.0167 m3/ min) x sample duration ( 480 min).

Table 6.11. Short, Intermediate, and Long Term Inhalation Exposures and MOEs for Pressure Treatment Handler and Post application Scenarios Exposure Scenario Surrogate Inhalation Unit Exposurea ( µ g As/ ppm) Application Rate (% ai solution) Absorbed Daily Dosesb ( mg/ kg/ day) Inhalation MOEsc ( Target MOE = 100) Occupational Handler Treatment Operator ( TO) 0.00257 3 0.0013 2,300 Treatment Assistant ( TA) 0.000802 3 0.00040 7,500 Occupational Post application All ( Tram setter, stacker operator, loader operator, supervisor, test borer, and tallyman) 0.00160 3 0.00080 3,800 a. Unit exposure values taken from CCA study and are shown in Table 6.11. b. Absorbed Daily Dose ( mg/ kg/ day) = Unit Exposure ( µ g As/ ppm) x [% ADBAC in solution ( 3) x 10,000 ( parts per million conversion)] x ( 0.001 mg/ µ g) x absorption factor ( 100% for inhalation) / Body weight ( 60 kg). c. MOE = NOAEL ( mg/ kg/ day) / Daily dose [ Where inhalation NOAEL = 3 mg/ kg/ day for all durations. Target MOE = 100.

6.4 Data Limitations/ Uncertainties There are several data limitations and uncertainties associated with the occupational handler and post application exposure assessments. These include:

  Surrogate dermal and inhalation unit exposure values were taken from the proprietary Chemical Manufacturers Association ( CMA) antimicrobial exposure study ( USEPA, 1999: DP Barcode D247642) or from the Pesticide Handler Exposure Database ( USEPA, 1998) ( See Appendix B for summaries of these data sources). Since the CMA data are of poor quality, the Agency requests that confirmatory data be submitted to support the occupational scenarios assessed in this document.   Unit exposures are not available for some of the specific scenarios that are prescribed for ADBAC. These scenarios include the following: open loading into oil well/ field environments and metering into once through cooling water systems at power plants. Page 61 of 107 o The CMA data used for oil well uses are based on open pouring of a material preservative. Although these data are only represented by 2 replicates each, the exposure values are similar to open loading of pesticides in PHED. Furthermore, there are no representative unit exposure data for chemical metering into secondary recovery oil operations. Since the volume of water being treated in secondary recovery operations is so large, the available CMA data can not be reliably extrapolated because they are based on activities that handle much lower volumes and possibly different techniques. Therefore, it was assumed that if the open pour handling activities for the other oil well operations resulted in MOEs that are not of concern, then the MOEs for the closed system chemical metering into secondary recovery operations would also be not of concern. AD requests that confirmatory data be conducted to show that this is accurate. o The CMA data used for once through cooling water systems at power plants are based on closed metering for pulp and paper. The pulp and paper unit exposures were deemed more appropriate than the cooling water tower data because of the large volume of water treated in once through cooling water systems at power plants. However, the CMA data for pulp and paper still does not reliably represent the large volume of water treated in a once through cooling water system and the possibly different techniques used to treat the water.   For the wood preservative pressure treatment scenarios, CCA exposure data were used for lack of ADBAC specific exposure data and for the wood preservative non pressure treatment scenarios, DDAC exposure data were used for the lack of ADBAC specific exposure data. Limitations and uncertainties associated with the use of these data include: o The assumption was made that exposure patterns for workers at treatment facilities using CCA and DDAC would be similar to exposure patterns for workers at treatment facilities using ADBAC, and therefore the exposures could be used as surrogate data for workers that treat wood with ADBAC. o For environmental modeling, it was assumed that the leaching process from the ADBAC treated wood would be similar to that of CCA and DDAC. However, due to the lack of real data for ADBAC  treated wood, it is not possible to verify this assumption.   The quantities handled/ treated were estimated based on information from various sources, including HED's Standard Operating Procedures ( SOPs) for Residential Exposure Assessments ( USEPA, 2000 and 2001), and personal communication with experts. In particular, the use information for the pulp and paper processing, oil well uses, and cooling water tower uses are based on personal communication with biocide manufacturers for these types of uses. The individuals contacted have experience in these operations and their estimates are believed to be the best available without undertaking a statistical survey of the uses. In certain cases, no standard values were available for some scenarios. Assumptions for these scenarios were based on AD estimates and could be further refined from input from registrants. For example, the quantities handled/ treated for the application of ADBAC to the surface of metal/ wood cooling towers could be refined.   The percent active ingredient in solution for the pressure treatment of lumber needs to be refined by the Registrant. The labels only provided a retention rate. For this assessment, Page 62 of 107 the application rate on the master label was used, which is the same as the application rate for non pressure treatment of lumber.   The type of spray equipment to be used was not specifically mentioned on the labels for some scenarios, such as for surface sprays to metal and wood cooling water towers. Therefore, these scenarios were assessed using the PHED airless spray unit exposures, which represents high end exposure. In these cases, the appropriate application equipment could be further refined. Page 63 of 107 7.0 REFERENCES American Chemistry Council ( ACC). 2002a. Assessment of Potential Inhalation and Dermal Exposure Associated With Pressure Treatment of Wood with Arsenical Wood Products. MRID 4550211 01.

American Chemistry Council ( ACC). 2002b. An Analysis of the Training Patterns and Practices of Competitive Swimmers. Prepared by Richard Reiss. Sciences International, Inc. Alexandria, Virginia. December 9, 2002.

American Chemical Council ( ACC), 2005. Slimicide Use in Papermaking ( Powerpoint Presentation). ACC Biocides Council, September 17, 2003.

Bestari KT, Macey K, Soloman KR, Tower N. 1999. Measurement and Assessment of Dermal and Inhalation Exposures to Didecyl Dimethyl Ammonium Chloride ( DDAC) Used in the Protection of Cut Lumber ( Phase III). MRID 455243 04.

Bryan, Elizabeth. 1988. Methods for Estimating Retention of Liquid on Hands. Volume 13 of Methods for Assessing Exposure to Chemical Substances. EPA 560/ 5 85 017 CEC, 2001. Residential Manual for Compliance with California's 2001 Energy Efficiency Standards. http:// www. energy. ca. gov/ title24/ residential_ manual/ index. html, viewed January 2005.

DOE. 1997. Energy Information Administration: Profile of Commercial Buildings in 1995. http:// www. eia. doe. gov/ emeu/ cbecs/ char95/ profile. html Freeman, N , Jimenez M, Reed KJ, Gurunathan S, Edwards RD, Roy A, Adgate JL, Pellizzari ED, Quackenboss J, Sexton K, Lioy PJ, 2001. Quantitative analysis of chilren's microactivity patterns: The Minnesota Children's Pesticide Exposure Study. Journal of Exposure Analysis and Environmental Epidemiology. 11( 6): 501 509.

Helwig, D. ( 2003) Personal Communication between D. Helwig ( Johnson Diversy, Inc) and K. Riley ( Versar, Inc.), November 11, 2003.

HERA, 2003. Human and Environmental Risk Assessment, Guidance Document Methodology, April 22, 2002 ( http:// www. heraproject. com/ files/ Guidancedocument. pdf).

HERA, 2005. Human and Environmental Risk Assessment, Guidance Document Methodology, February 2005 ( http:// www. heraproject. com).

MCCEM V 1.2 The Multi Chamber Concentration and Exposure Model ( MCCEM) Model Version 1.2. Prepared for the US EPA Office of Pollution Prevention and Toxics. Prepared by Versar, Inc. and Wilkes Technologies, LLC.

Jacobson, Larry. 2005. Professor and Extension Engineer at University of Minnesota. Page 64 of 107 SIMetric. 2005. http:// www. simetric. co. uk/ si_ materials. htm Last viewed November 9, 2005.

USEPA. Undated. RISK. Version 1.9.27. Developed by Dr. Les Sparks of USEPA/ NRMRL/ APPCD.

USEPA. 1996. Office of Research and Development, Descriptive Statistics Tables from a Detailed Analysis of the National Human Activity Pattern ( NHAPS) Data; EPA/ 600/ R 96/ 148, July 1996. Data Collection Period October 1992  September 1994 .

USEPA. 1997. Exposure Factors Handbook. Volume I II. Office of Research and Development. Washington, D. C. EPA/ 600/ P 95/ 002Fa. August 1997.

USEPA. 1998. PHED Surrogate Exposure Guide. Estimates of Worker Exposure from the Pesticide Handler Exposure Database Version 1.1. Washington, DC: U. S. Environmental Protection Agency.

USEPA. 1999. Evaluation of Chemical Manufacturers Association Antimicrobial Exposure Assessment Study ( Amended on 8 December 1992). Memorandum from Siroos Mostaghimi, PH. D., USEPA to Julie Fairfax, USEPA. Dated November, 4 1999. DP Barcode D247642.

USEPA. 2000. Residential SOPs. EPA Office of Pesticide Programs, Human Health Effects Division. Dated April 5, 2000.

USEPA. 2001. HED Science Advisory Council for Exposure. Policy Update, November 12. Recommended Revisions to the Standard Operating Procedures ( SOPs) for Residential Exposure Assessment, February 22, 2001.

USEPA. 2003. Assessment of the Proposed Bardac Wood Preservative Pressure Treatment Use. Memorandum from Tim Leighton and Siroos Mostaghimi. February 11, 2003.

USEPA. 2004. Occupational and Residential Exposure Assessment for Carboquat WP 50. Memorandum from Siroos Mostaghimi, USEPA to Welma Noble, USEPA. Dated November 4, 2004. DP Barcodes D303714 and D303938.

USEPA. 2006. Alkyl dimethyl benzyl ammonium chloride ( ADBAC)   Report of the Antimicrobials Division Toxicity Endpoint Committee ( ADTC) and the Hazard Identification Assessment Review Committee ( HIARC). January 9, 2006. Page 65 of 107 APPENDIX A: Master ADBAC Label Page 66 of 107 EPA Reg Number used for Max. Appl. Rate Use Site Treatment Site/ Surfaces Method of Application Notes Freq of Application Industrial processes and water systems 10324 21 Industrial Recirc Water Systems Cooling Tower Pour/ metered As needed 10324 102 Industrial Recirc Water Systems Waste water treatment Pour/ metered As needed 10324 102 Industrial Recirc Water Systems Evaporative condenser Pour/ metered As needed 6836 58 Industrial Recirc Water Systems Pulp/ Paper Pour/ metered As needed 10324 21 Once through Cooling As needed 6836 234 Food Contact Recirc Water Brewery pasteurizers Pour/ metered As needed 1706 177 Pulp/ Paper Pour/ metered As needed 1757 99 Industrial Recirc Water Systems Cooling Tower Pour/ metered As needed 1839 179 Oil Field injection and wastewater continuous injection As needed 1839 179 Oil Field injection and wastewater batch treatment As needed 1839 179 Oil Field packer fluids As needed 1839 179 Oil Field drilling muds As needed Swimming Pools 6836 310 Swimming Pool Weekly 1839 141 Swimming Pool Pour Weekly 1839 141 Outside Spas/ Whirlpools/ Hot Tub Bath Pour As needed Aquatic Areas 53642 1 fountains, water displays, decorative pools, decorative ponds, sewage treatment systems, spas, standing water spray Mosquito Control 499 368 decorative pools, fountains, water displays pour 499 482 nurseries watering lines, watering tubes, emitters, drip lines, watering nozzles and hoses pour, immerse Wood Preservatives 6836 308 Pressure Treatment lumber 3% ai soln As needed 6836 308 Double vacuum lumber 3% ai soln As needed 1839 184 Dip/ Brush/ Spray surface treatment lumber 3% ai soln As needed Page 67 of 107 EPA Reg Number used for Max. Appl. Rate Use Site Treatment Site/ Surfaces Method of Application Notes Freq of Application 1839 184 sapstain control lumber dip, spray As needed Agricultural Premise and Equipment 10324 111 Animal facilities, farms, mushroom farms, animal life science laboratories, animal quarters, other animal care facilities, hatcheries, stables, catteries, stalls, animal transportation vehicles Dairy/ equine/ hog/ swine/ pou ltry/ turkey farms, hatcheries, barns, pens, stalls, egg receiving area, egg holding area, setter room, tray dumping area, chick holding room, poultry buildings, dressing plants, offal rooms, farrowing barns and areas, nursery, blocks, creep areas, hatcheries, stables, catteries, chick holding area, hatchery room, chick processing area, chick loading area, offal rooms, animal transportation vehicles Floors, walls, ceilings, feed racks, mangers, troughs, automatic feeders/ fountains/ waterers, other feeding and watering appliances, halters, ropes and other types of equipment used in handling and restraining animals, as well as forks, shovels, and scrapers used for removing litter and manure, feeders, fountains, drinkers, blocks, chutes, incubators, hatchers, waterers, feeders, fountains, hauling equipment, loading equipment, kennels, runs, cages, coops, crates, pens, trays, buggies, racks, carts, egg flats, drinkers, fixtures, delivery trucks, trucks/ trailers, field harvesting equipment, including cargo area, wheels, tires, undercarriage, hood, roof, fenders and any other part of the transportation equipment mop, wipe ( cloth, swab), pour, immersion As needed 10324 111 gloves immersion As needed 6836 193 hatcheries, egg receiving area spray ( RTU spray/ wipe) As needed 1839 81 hatcheries hatchery rooms fogging As needed 10324 81 hatcheries incubators, setters, hatchers fogging every 12 hrs 67517 15 hatcheries egg shell sanitizing spray, immersion, cloth 1/ batch of eggs 1839 86 Shoe immersion/ foam generating machine/ aerator As needed Page 68 of 107 EPA Reg Number used for Max. Appl. Rate Use Site Treatment Site/ Surfaces Method of Application Notes Freq of Application 10324 140 Animal facilities, farms, mushroom farms, animal life science laboratories, animal quarters, other animal care facilities, hatcheries, stables, catteries, stalls, animal transportation vehicles Dairy/ equine/ hog/ swine/ pou ltry/ turkey farms, hatcheries, barns, pens, stalls, egg receiving area, egg holding area, setter room, tray dumping area, chick holding room, poultry buildings, dressing plants, offal rooms, farrowing barns and areas, nursery, blocks, creep areas, hatcheries, stables, catteries, chick holding area, hatchery room, chick processing area, chick loading area, offal rooms, animal transportation vehicles Floors, walls, ceilings, feed racks, mangers, troughs, automatic feeders/ fountains/ waterers, other feeding and watering appliances, halters, ropes and other types of equipment used in handling and restraining animals, as well as forks, shovels, and scrapers used for removing litter and manure, feeders, fountains, drinkers, blocks, chutes, incubators, hatchers, waterers, feeders, fountains, hauling equipment, loading equipment, kennels, runs, cages, coops, crates, pens, trays mop, cloth, sponge, sprayer, RTU spray/ wipe Kills Canine parvo virus As needed 10324 80 citrus grove or farm trucks, vehicles, equipment, trailers, field harvesting equipment, cargo area, wheels, tires, under carriage, hood, roof, fenders trigger spraying, dipping, brushing Blend  Kills Citrus canker As needed 1839 81 Animal facilities, farms, mushroom farms, animal life science laboratories, animal quarters, other animal care facilities, hatcheries, stables, catteries, stalls, animal transportation vehicles Dairy/ equine/ hog/ swine/ pou ltry/ turkey farms, hatcheries, barns, pens, stalls, egg receiving area, egg holding area, setter room, tray dumping area, chick holding room, poultry buildings, dressing plants, offal rooms, farrowing barns and areas, nursery, blocks, creep areas, hatcheries, stables, catteries, chick holding area, hatchery room, chick processing area, chick loading area, offal rooms, animal transportation vehicles Personal protective safety equipment, protective headgear, hard hats, half mask respirators, full face breathing apparatus, gas masks, goggles, spectacles, face shields, hearing protectors/ ear muffs As needed 1072 16 stables, dairies Dairy and Hoof trimming equipment cloth, mop, sponge, sprayer, immersion As needed 507 3 greenhouses, nurseries ornamental crops drench or spray Once or every 5 15 days dependent on type of crop 507 3 greenhouses, nurseries hands and gloves immersion as needed Page 69 of 107 EPA Reg Number used for Max. Appl. Rate Use Site Treatment Site/ Surfaces Method of Application Notes Freq of Application 53642 1 greenhouses, nurseries work areas, benches, pots, flats, flower buckets, cutting tools, greenhouse glass, bird baths, walkways, houseplants Spray, swab, immersion As needed 53642 1 greenhouses, nurseries lawns, golf courses, commercial turf spray every 10 14 days during warm season 499 368 greenhouses, nurseries cutting tools immersion 499 368 greenhouses, nurseries evaporative coolers, cooler pads spray or swab every other week Medical premises and equipment 10324 111 day care centers, hospitals, medical/ dental offices, nursing homes, other health care institutions, mortuaries, autopsy rooms, EMS facilities, medical research facilities, patient care rooms, recovery anesthesia rooms, operating rooms Metal, stainless steel, glazed porcelain, glazed ceramic tile, plastic, granite, marble, chrome, vinyl, glass, chrome plated intakes, enameled surfaces, painted woodwork, Formica, vinyl and plastic upholstery, floors, walls, toilets, urinals, lavatories, bathrooms, bathing areas, bathtubs, sinks, sink tops, shower stalls, shower doors/ curtains, mirrors, ultrasonic bath, whirlpools, foot baths, countertops, cabinets, tables, chairs, desks, hospital beds, bed springs, bed frames, traction devices, MRI, CAT, examining tables, scales, paddles, wheelchairs, lifts, door knobs, linen carts, hampers, wheel chairs, telephones, fixtures, toys, high chairs, cribs, changing tables mop, wipe ( cloth, swab), pour, immersion As needed 1020 1 Hospitals hard/ non porous surfaces ( nonfood contact) mop, brush, cloth or sponge 6836 193 day care centers, hospitals, medical/ dental offices, nursing homes, other health care institutions, mortuaries, autopsy rooms, EMS facilities, medical research facilities, patient care rooms, recovery anesthesia rooms, operating rooms Metal, stainless steel, glazed porcelain, glazed ceramic tile, plastic, granite, marble, chrome, vinyl, glass, chrome plated intakes, enameled surfaces, painted woodwork, Formica, vinyl and plastic upholstery, floors, walls, toilets, urinals, lavatories, bathrooms, bathing areas, bathtubs, sinks, sink tops, shower stalls, shower doors/ curtains, mirrors, ultrasonic bath, whirlpools, foot baths, countertops, cabinets, tables, chairs, desks, hospital beds, bed springs, bed frames, traction devices, MRI, CAT, examining tables, scales, paddles, wheelchairs, lifts, door knobs, linen carts, hampers, wheel chairs, telephones, fixtures spray ( RTU spray/ wipe) As needed Page 70 of 107 EPA Reg Number used for Max. Appl. Rate Use Site Treatment Site/ Surfaces Method of Application Notes Freq of Application 1839 81 Hospitals carpet portable extraction units, truck mounted extraction machines, rotary floor machines, metered, spray As needed 1839 155 Hospitals laundry pour @ final rinse cycle As needed 1839 110 hospital fabric final rinse in wash cycle As needed 1190 48 Hospitals, Health Care facilities, Medical/ Dental offices, Nursing homes, operating rooms, patient care facilities, clinics, isolation wards, medical research facilities, autopsy rooms, ICU areas, recovery anesthesia, emergency rooms, X ray cat labs, newborn nurseries, orthopedics, respiratory therapy, acute care institutions, alternate care institutions, healthcare institutions, restrooms/ bathrooms floors, walls, toilets, urinals, lavatories, bathrooms, bathing areas, bathtubs, sinks, sink tops, shower stalls, shower doors/ curtains, mirrors, ultrasonic bath, whirlpools, foot baths, countertops, cabinets, tables, chairs, desks, hospital beds, bed springs, bed frames, traction devices, MRI, CAT, examining tables, scales, paddles, wheelchairs, lifts, door knobs, linen carts, hampers, wheel chairs, telephones, garbage pails/ cans, fixtures Wipe, mop, spray, ( cloth) swab, brush As needed 1839 81 autopsy rooms, funeral homes, human remains sponge, wash cloth, soft brush As needed 5741 2 hospitals walls, floors, and other hard, non porous mop, sponge, or spray 62401 6 nursing homes walls, telephones, chairs, tables, sinks, counters, appliance exteriors, garbage cans, stovetops Presaturated wipe As needed 7211 10 Medical Premises & Equipment critical instruments immersion 1203 41 hospitals, nursing homes, clinics tables, walls, ceramic tiles, metal surfaces, plastic, asphalt, finished/ painted wood and glass spray, mop, sponge As needed 10324 80 hospitals, nursing homes air ducts spray, brush, mop, wipe, ULV or mist generating, automated spray odor causing bacteria, fungi, 6 months Commercial, institutional, and industrial premises and equipment Page 71 of 107 EPA Reg Number used for Max. Appl. Rate Use Site Treatment Site/ Surfaces Method of Application Notes Freq of Application 10324 111 hair/ nail salons, barber beauty shops, tanning salons, tattoo parlors, veterinary clinics, locker facilities, shopping malls, motels, hotels, bookstores, dressing rooms, photo copy centers, bicycle shopes, toy factories, computer manufacturing sites, burial vaults, mausoleums, jails, penitentiaries, transportation terminals, Cruise ships, airplanes, schools, universities, churches, libraries, cosmetic manufacturing facilities, medical device manufacturing facilities, pharmaceutical manufacturing facilities, bowling alleys, crime scenes, pet shops, grooming and breeding establishments, zoos, tack shops, atheletic facilities, Sport Arenas, floors, walls, toilets, urinals, bathrooms, bathtubs, sinks, countertops, shower doors/ curtains, toilet seats, shower stalls, ultrasonic bath, whirlpools, barber/ salon instruments/ tools, tables, chairs, shelves, telephones, cabinets, desks, tanning beds, bed springs, door knobs, linen carts, hampers, garbage pails, telephones, recycling equipment, exercise equipment, automobile/ truck interiors, garbage cans/ pails, metal, stainless steel, glazed porcelain, glazed ceramic tile, plastic, granite, marble, chrome, vinyl, glass, chrome plated intakes, enameled surfaces, painted woodwork, Formica, vinyl and plastic upholstery, terrariums, cages, and cage furniture mop, wipe ( cloth, swab), pour, immersion As needed 1839 81 manufacturing sites/ facilities fogging As needed 6836 193 hair/ nail salons, barber beauty shops, tanning salons, tattoo parlors, veterinary clinics, locker facilities, shopping malls, motels, hotels, bookstores, dressing rooms, photo copy centers, bicycle shopes, toy factories, computer manufacturing sites, burial vaults, mausoleums, jails, penitentiaries, transportation terminals, Cruise ships, airplanes, schools, universities, churches, libraries, cosmetic manufacturing facilities, medical device manufacturing facilities, pharmaceutical manufacturing facilities, bowling alleys, crime scenes, pet shops, grooming and breeding establishments, zoos, tack shops, atheletic facilities, Sport Arenas, hair/ nail salons, barber beauty shops, tanning salons, tattoo parlors, veterinary clinics, locker facilities, shopping malls, motels, hotels, bookstores, dressing rooms, photo copy centers, bicycle shopes, toy factories, computer manufacturing sites, burial vaults, mausoleums, jails, penitentiaries, transportation terminals, Cruise ships, airplanes, schools, universities, churches, libraries, cosmetic manufacturing facilities, medical device manufacturing facilities, pharmaceutical manufacturing facilities, bowling alleys, crime scenes, pet shops, grooming and breeding establishments, zoos, tack shops, atheletic facilities, Sport Arenas, spray ( RTU spray/ wipe) As needed 1839 81 hotels, motels, dressing romms, bowling alleys, salons, libraries, office buildings, schools, universities carpet portable extraction units, truck mounted extraction machines, rotary floor machines, metered, spray As needed 62401 6 schools, food service establishments telephones, walls, chairs, tables, sinks, counters, appliance exteriors, garbage cans, stovetops Presaturated wipe As needed Page 72 of 107 EPA Reg Number used for Max. Appl. Rate Use Site Treatment Site/ Surfaces Method of Application Notes Freq of Application 1839 155 hotels, motels, dressing romms, bowling alleys, salons, libraries, office buildings, schools, universities laundry pour @ final rinse cycle As needed 1839 110 commercial fabric final rinse in wash cycle As needed 1839 120 humidifier pour As needed 1839 81 Florists/ flower shops, greenhouses, shippers, packing areas flower buckets, coolers, floors and walls of coolers, design and packing benches, garbage pails Mop/ wipe, cloth, brush, sponge, sprayer, RTU wipe/ spray As needed 10324 140 kennels, breeding facilities, tack shops, pet shops, Floors, walls, ceilings, feed racks, mangers, troughs, automatic feeders/ fountains/ waterers, other feeding and watering appliances, halters, ropes and other types of equipment used in handling and restraining animals, as well as forks, shovels, and scrapers used for removing litter and manure, feeders, fountains, drinkers, blocks, chutes, incubators, hatchers, waterers, feeders, fountains, hauling equipment, loading equipment, kennels, runs, cages, coops, crates, pens, trays mop, cloth, sponge, sprayer, RTU spray/ wipe Kills Canine parvo virus As needed 1839 85 hair/ nail salons, barber beauty shops, tanning salons, tattoo parlors, veterinary clinics, locker facilities, shopping malls, motels, hotels, bookstores, dressing rooms, photo copy centers, bicycle shopes, toy factories, computer manufacturing sites, burial vaults, mausoleums, jails, penitentiaries, transportation terminals, Cruise ships, airplanes, schools, universities, churches, libraries, cosmetic manufacturing facilities, medical device manufacturing facilities, pharmaceutical manufacturing facilities, bowling alleys, crime scenes, pet shops, grooming and breeding establishments, zoos, tack shops, atheletic facilities, Sport Arenas, air deodorizer/ air freshener RTU spray As needed 10324 111 Sports Arenas, exercise facilities, amusement parks, schools, day care centers large inflatable non porous plastic and rubber structures ( animals, promotional items, moonwalk, slides, obstacle course play equipment, exercise equipment, wrestling mats, bathrooms mop, cloth, sponge, sprayer mildewstat As needed Page 73 of 107 EPA Reg Number used for Max. Appl. Rate Use Site Treatment Site/ Surfaces Method of Application Notes Freq of Application 5741 2 schools, hotels, restaurants, commercial, institutional, and industrial facilities walls, floors, and hard, non porous mop, sponge, or spray 1839 81 manufacturing sites/ facilities Personal protective safety equipment, protective headgear, hard hats, half mask respirators, full face breathing apparatus, gas masks, goggles, spectacles, face shields, hearing protectors/ ear muffs sponge, wash cloth, soft brush, immerse As needed 32977 1 schools and music stuidos wind instruments immersion As needed 1203 41 Athletic facilities, motels, hotels, churches, convents, transportation terminals, tables, walls, ceramic tiles, metal surfaces, plastic, asphalt, finished/ painted wood and glass spray, mop, sponge As needed 507 3 industrial premises hands and gloves immersion as needed 10324 80 Institutional, Industrial premise, school, restaurant air ducts spray, brush, mop, wipe, ULV or mist generating, automated spray odor causing bacteria, fungi, 6 months Residential and public access premises 10324 111 Households, campgrounds, playgrounds, picnic facilities, recreational facilities, other public facilities Floors, walls, windows, toilets, bathtubs, whirlpools, shower stalls, shower door/ curtain, sinks, mirrors, restroom fixtures, cabinets, tables, chairs, desks, bed frames, doorknobs, garbage cans/ pails, picnic tables, outdoor furniture, telephones, countertops, external surfaces of appliances, tables, sincks, shelves, plastic chopping blocks, metal, stainless steel, glazed porcelain, glazed ceramic tile, plastic, granite, marble, chrome, vinyl, glass, chrome plated intakes, enameled surfaces, painted woodwork, Formica, vinyl, plastic upholstery, terrariums, cages, and cage furniture As needed 10324 111 RVs, motor homes RV Holding Tank Pouring As needed Page 74 of 107 EPA Reg Number used for Max. Appl. Rate Use Site Treatment Site/ Surfaces Method of Application Notes Freq of Application 6836 193 Households, campgrounds, playgrounds, picnic facilities, recreational facilities, other public facilities Floors, walls, windows, toilets, bathtubs, whirlpools, shower stalls, shower door/ curtain, sinks, mirrors, restroom fixtures, cabinets, tables, chairs, desks, bed frames, doorknobs, garbage cans/ pails, picnic tables, outdoor furniture, telephones, countertops, external surfaces of appliances, tables, sincks, shelves, plastic chopping blocks, metal, stainless steel, glazed porcelain, glazed ceramic tile, plastic, granite, marble, chrome, vinyl, glass, chrome plated intakes, enameled surfaces, painted woodwork, Formica, vinyl, plastic upholstery, terrariums, cages, and cage furniture spray ( RTU spray/ wipe) As needed homes carpet portable extraction units, truck mounted extraction machines, rotary floor machines, metered, spray As needed 1839 120 homes humidifier pour As needed 1839 85 homes air deodorizer/ air freshener RTU spray As needed 62401 6 homes walls, telephones, chairs, tables, sinks, counters, appliance exteriors, garbage cans, stovetops Presaturated wipe As needed 1839 155 homes water softeners and reverse osmosis units As needed 10324 80 homes air ducts spray, brush, mop, wipe, ULV or mist generating, automated spray odor causing bacteria, fungi, 6 months Food handling/ storage establishments premises and equipment Page 75 of 107 EPA Reg Number used for Max. Appl. Rate Use Site Treatment Site/ Surfaces Method of Application Notes Freq of Application 10324 111 restaurants, bars, supermarket, convenience stores, pizza parlors, meat and poultry processing plants, rendering plants, fish, milk, wine, citrus processing facilities, institutional kitchens, food storage areas, tobacco processing facilities, ood service establishments, food processing plants/ facilities, beverage processing plants, Cafeterias, Dairies, Egg Processing plants, Federally inspected meat and poultry plants, Food Handling areas, Food preparation areas, Food storage areas, USDA inspected food processing facilities, breweries, fast food operations floors, walls, countertops, appliances ( microwaves, refrigerators, stove tops, freezers, coolers), chairs, tables, shelves, picnic tables, outdoor furniture, racks, carts, telephones, door knobs, storage areas, potato storage areas, food storage areas, garbage storage areas, cutting boards, tanks, exhaust fans, refrigerator bins, refrigerated storage/ display equipment, coils and drain pans of air conditioning/ refrigeration equipment, heat pumps, storage tanks, coolers, ice chests, garbage cans/ pails metal, stainless steel, glazed porcelain, glazed ceramic tile, plastic, granite, marble, chrome, vinyl, glass, chrome plated intakes, enameled surfaces, painted woodwork, Formica, vinyl and plastic upholstery mop, wipe ( cloth, swab), pour, immersionmop, wipe ( cloth, swab), pour, immersion As needed 10324 111 federally inspected meat and poultry plants, food processing facilities, dairies, tobacco processing facilities, beverage processing facilities gloves immersion As needed 507 3 dairies and food processing plants hands and gloves immersion as needed 1839 86 federally inspected meat and poultry plants, food processing facilities, dairies, tobacco processing facilities, beverage processing facilities Shoe immersion/ foam generating machine/ aerator As needed 6836 193 restaurants, bars, supermarket, convenience stores, pizza parlors, meat and poultry processing plants, rendering plants, fish, milk, wine, citrus processing facilities, institutional kitchens, food storage areas, tobacco processing facilities, ood service establishments, food processing plants/ facilities, beverage processing plants, Cafeterias, Dairies, Egg Processing plants, Federally inspected meat and poultry plants, Food Handling areas, Food preparation areas, Food storage areas, USDA inspected food processing facilities, breweries, fast food operations floors, walls, countertops, appliances ( microwaves, refrigerators, stove tops, freezers, coolers), chairs, tables, shelves, picnic tables, outdoor furniture, racks, carts, telephones, door knobs, storage areas, potato storage areas, food storage areas, garbage storage areas, cutting boards, tanks, exhaust fans, refrigerator bins, refrigerated storage/ display equipment, coils and drain pans of air conditioning/ refrigeration equipment, heat pumps, storage tanks, coolers, ice chests, garbage cans/ pails metal, stainless steel, glazed porcelain, glazed ceramic tile, plastic, granite, marble, chrome, vinyl, glass, chrome plated intakes, enameled surfaces, painted woodwork, Formica, vinyl and plastic upholstery RTU Spray/ wipe As needed Page 76 of 107 EPA Reg Number used for Max. Appl. Rate Use Site Treatment Site/ Surfaces Method of Application Notes Freq of Application 1839 155 ( FCS) restaurants, food service establishments, Bars, Cafeteria, convenience stores, dairies, food handling areas, food preparation areas, food storage areas institutional kitchens, fast food operations dairy equipment, dairy farm bulk milk tanks, milking equipment, tanks, piping, pasteurizers, cow udders, dairy product dispensing equipment, drinking glasses, eating utensils, cooking utensils, silverware, glassware, dishes, ice machines, beverage dispensing equipment, counters, tables, cutting boards, Slurrpy machines, ice cream dispensing equipment, food dispensing equipment, utensils and other food contact articles spray, flood, immersion, brushing, RTU wipe/ spray As needed 1839 51 Food processing plants/ facilities ( including beverage, meat, poultry, egg, seafood, fisheries, milk, citrus, potato, ice cream), Egg Processing plants, Federally inspected meat and poultry plants, Food Handling areas, Food preparation areas, Food storage areas, USDA inspected food processing facilities, breweries storage tanks, meat/ poultry/ fruit/ vegetable conveyers, tanks, chopping block, countertops, sinks, sink tops, utensils, knives, grinders, shredders, cleavers, ladles, food grade eggs, ice machines, water coolers, water holding tanks, pressure tanks, refrigerated storage/ display equipment, exhaust fans, coils and drain pans of air conditioning/ refrigeration equipment, heat pumps, storage tanks, beer fermentation equipment and holding tanks, blenders, food processors, bottling or pre mix dispensing equipment, citrus processing equipment ( holding tanks, bottles, cans), cutting boards, coolers, ice chests, ice machines, refrigerator bins, beer fermentation and storage tanks spray, flood, immersion, brushing, RTU wipe/ spray As needed 1839 155 water softeners and reverse osmosis units As needed 1839 81 dairies, beverage and food processing plants room surfaces fogging As needed 1020 1 food and bottling plant, dairy farms, egg product processing plants and milk plants walls, floors, equipment, other hard nonporous surfaces mop, brush, cloth or sponge 1203 41 food processing plants, food service areas, institutional kitchens, industrial/ hospital cafeterials, school lunchrooms, canning plants, dairies, and packing plants tables, walls, ceramic tiles, metal surfaces, plastic, asphalt, finished/ painted wood and glass spray, mop, sponge As needed 10324 80 food processing plants, food service areas, institutional kitchens, industrial/ hospital cafeterials, school lunchrooms, dairies, and packing plants air ducts spray, brush, mop, wipe, ULV or mist generating, automated spray odor causing bacteria, fungi, 6 months Cleaning/ Deodorizing Page 77 of 107 EPA Reg Number used for Max. Appl. Rate Use Site Treatment Site/ Surfaces Method of Application Notes Freq of Application 10324 118 residential, commercial, institutional, industrial, garbage cans, garbage trucks, industrial waste receptacles, garbage handling equipment sprayer, sponge, cloth, Cleaning/ Deodorizing As needed 1839 81 Water/ Smoke restoration ( institutional, industrial, hospital, nursing home) carpets, carpet cushion, sub floors, drywall, trim, farm lumber, tackless strip and paneling Mop/ wipe, cloth, brush, sponge, sprayer Cleaning/ Deodorizing As needed 10324 118 Sewer backup/ river flood cleanup/ clean water source carpets, carpet cushion, sub floors, drywall, trim, farm lumber, tackless strip and paneling spray Cleaning/ Deodorizing As needed 5174 22 schools, day care centers, restaurants, cafeterias, convenience stores, kennels, restrooms, hospitals, nursing homes hard non porous surfaces mop, sponge, or spray Cleaning/ Deodorizing As needed Page 78 of 107 APPENDIX B: Summary of CMA and PHED Data Page 79 of 107 Chemical Manufacturers Association ( CMA) Data: In response to an EPA Data Call In Notice, a study was undertaken by the Institute of Agricultural Medicine and Occupational Health of The University of Iowa under contract to the Chemical Manufacturers Association. In order to meet the requirements of Subdivision U of the Pesticide Assessment Guidelines ( superseded by Series 875.1000 875.1600 of the Pesticide Assessment Guidelines), handler exposure data are required from the chemical manufacturer specifically registering the antimicrobial pesticide. The applicator exposure study must comply with the assessment guidelines for A Applicator Exposure Monitoring @

in Subdivision U and the A Occupational and Residential Exposure Test Guidelines @

in Series 875. For this purpose, CMA submitted a study on 28 February, 1990, entitled " Antimicrobial Exposure Assessment Study ( amended on December 8, 1992)" which was conducted by William Popendorf, et al. It was evaluated and accepted by Occupational and Residential Exposure Branch ( OREB) of Health Effect Division ( HED), Office of Pesticides Program ( OPP) of EPA in 1990. The purpose of this CMA study was to characterize exposure to antimicrobial chemicals in order to support pesticide reregistrations ( CMA, 1992). The unit exposures presented in the most recent EPA evaluation of the CMA database ( USEPA, 1999b) were used in this assessment.

The Agency determined that the CMA study had fulfilled the basic requirements of Subdivision U  Applicator Exposure Monitoring. The advantages of CMA data over other A surrogate data sets @

is that the chemicals and the job functions of mixer/ loader/ applicator were defined based on common application methods used for antimicrobial pesticides. A few of the deficiencies in the CMA data are noted below:

  The inhalation concentrations were typically below the detection limits, so the unit exposures for the inhalation exposure route could not be accurately calculated.   QA/ QC problems including lack of either/ or field fortification, laboratory recoveries, and storage stability information.   Data have an insufficient amount of replicates.

The Pesticide Handlers Exposure Database ( PHED): The Pesticide Handlers Exposure Database ( PHED) has been developed by a Task Force consisting of representatives from Health Canada, the U. S. Environmental Protection Agency ( EPA), and the American Crop Protection Association ( ACPA). PHED provides generic pesticide worker ( i. e., mixer/ loader and applicator) exposure estimates. The dermal and inhalation exposure estimates generated by PHED are based on actual field monitoring data, which are reported generically ( i. e., chemical specific names not reported) in PHED. It has been the Agency =

s policy to use A surrogate @

or A generic @

exposure data for pesticide applicators in certain circumstances because it is believed that the physical parameters ( e. g., packaging type) or application technique ( e. g., aerosol can), not the chemical properties of the pesticide, attribute to exposure levels. [ Note: Vapor pressures for the chemicals in PHED are in the range of E 5 to E 7 mm Hg.] Chemical specific properties are accounted for by correcting the exposure data for study specific field and laboratory recovery values as specified by the PHED grading criteria.

PHED handler exposure data are generally provided on a normalized basis for use in exposure assessments. The most common method for normalizing exposure is by pounds of active ingredient ( ai) handled per replicate ( i. e., exposure in mg per replicate is divided by the Page 80 of 107 amount of ai handled in that particular replicate). These unit exposures are expressed as mg/ lb ai handled. This normalization method presumes that dermal and inhalation exposures are linear based on the amount of active ingredient handled. Page 81 of 107 APPENDIX C: Input/ Output from Residential MCCEM Modeling Air Deodorization and Humidifier Page 82 of 107 MCCEM SUMMARY REPORT TITLE: Air Deodorization  Adult RUN Day Hour Min Length Days Hours Min Reporting TIME Start: 0 0 0 of Run: 2 0 0 Interval: 60 minutes HOUSE Type: Generic house State: NA Code: GN001 Season: SUMMER Zones: 2 Infiltration Rate: 0.18 ACH EMISSIONS Source Zone Type Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ 1 2 3 4 SINKS Sink Zone Model Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 2 3 4 5 6 ACTIVITIES Primary Activity Pattern is used on days: 1,2,3,4,5,6,7 OVERRIDE ACTIVITIES: YES DOSE Events/ yr: Yrs of Use: Weight( kg): 60 Length of Life( yrs):

MONTE CARLO: NO Number of Trials: 1 Seed No: Random OPTIONS Single Chamber: NO Saturation Concentration ( mg/ m ³ ) : NONE Output Concentration Units: mg/ m ³

Initial Concentrations Units: g/ m ³

Zone 1: 0.000066 Zone 2: 0 Zone 3: 0 Zone 4: 0 Outdoors: 0 Page 83 of 107 ____________________________________________________________________________ RESULTS ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ LADD: 1.4414e 06 mg/( kg day)

LADC: 7.2068e 06 mg/ m ³

ADD: 1.4414e 06 mg/( kg day)

ADC: 7.2068e 06 mg/ m ³

Single Event Dose: 0.031587 mg Peak Concentration: 0.06505 mg/ m ³

APDR: 0.00052301 mg/( kg day)

Time when APDR occurred: 1.0003 days Average Inhalation Rate: 12 m ³ / day Page 84 of 107 MCCEM SUMMARY REPORT TITLE: Air Deodorization  Child NOTES:

RUN Day Hour Min Length Days Hours Min Reporting TIME Start: 0 0 0 of Run: 2 0 0 Interval: 60 minutes HOUSE Type: Generic house State: NA Code: GN001 Season: SUMMER Zones: 2 Infiltration Rate: 0.18 ACH EMISSIONS Source Zone Type Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 2 3 4 SINKS Sink Zone Model Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 2 3 4 5 6 ACTIVITIES Primary Activity Pattern is used on days: 1,2,3,4,5,6,7 OVERRIDE ACTIVITIES: YES DOSE Events/ yr: Yrs of Use: Weight( kg): 15 Length of Life( yrs):

MONTE CARLO: NO Number of Trials: 1 Seed No: Random OPTIONS Single Chamber: NO Saturation Concentration ( mg/ m ³ ) : NONE Output Concentration Units: mg/ m ³ Page 85 of 107 Initial Concentrations Units: g/ m ³

Zone 1: 0.000066 Zone 2: 0 Zone 3: 0 Zone 4: 0 Outdoors: 0 ____________________________________________________________________________ RESULTS ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ LADD: 4.6123e 06 mg/( kg day)

LADC: 7.2068e 06 mg/ m ³

ADD: 4.6123e 06 mg/( kg day)

ADC: 7.2068e 06 mg/ m ³

Single Event Dose: 0.02527 mg Peak Concentration: 0.06505 mg/ m ³

APDR: 0.0016736 mg/( kg day)

Time when APDR occurred: 1.0003 days Average Inhalation Rate: 9.6 m ³ / day ____________________________________________________________________________ Page 86 of 107 MCCEM SUMMARY REPORT TITLE: Humidifier  8hrs  Adult RUN Day Hour Min Length Days Hours Min Reporting TIME Start: 0 0 0 of Run: 2 0 0 Interval: 60 minutes HOUSE Type: Generic house State: NA Code: GN001 Season: SUMMER Zones: 2 Infiltration Rate: 0.18 ACH EMISSIONS Source Zone Type Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 1 Constant Emission Rate = 0.102 g/ hr 2 3 4 SINKS Sink Zone Model Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 2 3 4 5 6 ACTIVITIES Primary Activity Pattern is used on days: 1,2,3,4,5,6,7 OVERRIDE ACTIVITIES: YES DOSE Events/ yr: Yrs of Use: Weight( kg): 60 Length of Life( yrs):

MONTE CARLO: NO Number of Trials: 1 Seed No: Random Page 87 of 107 OPTIONS Single Chamber: YES Saturation Concentration ( mg/ m ³ ) : 0 Output Concentration Units: mg/ m ³

Initial Concentrations Units: mg/ m ³

Zone 1: 0 Zone 2: 0 Zone 3: 0 Zone 4: 0 Outdoors: 0 ________________________________________________________________________ RESULTS ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

LADD: 0.0013458 mg/( kg day) LADC: 0.0067289 mg/ m ³ ADD: 0.0013458 mg/( kg day) ADC: 0.0067289 mg/ m ³ Single Event Dose: 29.493 mg Peak Concentration: 1.3894 mg/ m ³ APDR: 0.27692 mg/( kg day) Time when APDR occurred: 1.9587 days Average Inhalation Rate: 12 m ³ / day _______________________________________________________________________

Humidifier  8hrs  Adult Time ( days) Time ( hours) Conc Outdoors ( mg/ m ³ ) Conc Zone 1 ( mg/ m ³ ) Conc@ Pers on ( mg/ m ³ ) Dose ( mg/ kg/ day) MOE 0 0 0 0 0 0.0000 # DIV/ 0!

0.041667 1 8.65E 60 0.228802 0.228802 0.0019 1573 0.083333 2 3.27E 59 0.419933 0.419933 0.0035 857 0.125 3 6.95E 59 0.579594 0.579594 0.0048 621 0.166667 4 1.17E 58 0.712968 0.712968 0.0059 505 0.208334 5 1.74E 58 0.824381 0.824381 0.0069 437 0.25 6 2.38E 58 0.917451 0.917451 0.0076 392 0.291667 7 3.08E 58 0.995197 0.995197 0.0083 362 0.333334 8 3.83E 58 1.06014 1.06014 0.0088 340 0.375 9 4.63E 58 1.11439 1.11439 0.0093 323 0.416667 10 5.47E 58 1.15971 1.15971 0.0097 310 0.458334 11 6.33E 58 1.19757 1.19757 0.0100 301 0.5 12 7.22E 58 1.2292 1.2292 0.0102 293 0.541667 13 8.14E 58 1.25561 1.25561 0.0105 287 0.583334 14 9.07E 58 1.27768 1.27768 0.0106 282 0.625 15 1.00E 57 1.29612 1.29612 0.0108 278 0.666667 16 1.10E 57 1.31152 1.31152 0.0109 274 0.708334 17 1.19E 57 1.32438 1.32438 0.0110 272 0.750001 18 1.29E 57 1.33513 1.33513 0.0111 270 0.791667 19 1.39E 57 1.3441 1.3441 0.0112 268 0.833334 20 1.49E 57 1.3516 1.3516 0.0113 266 0.875001 21 1.59E 57 1.35787 1.35787 0.0113 265 0.916667 22 1.69E 57 1.3631 1.3631 0.0114 264 0.958334 23 1.79E 57 1.36747 1.36747 0.0114 263 1 24 1.89E 57 1.37112 1.37112 0.0114 263 1.04167 25 1.99E 57 1.37417 1.37417 0.0115 262 Page 88 of 107 Humidifier  8hrs  Adult Time ( days) Time ( hours) Conc Outdoors ( mg/ m ³ ) Conc Zone 1 ( mg/ m ³ ) Conc@ Pers on ( mg/ m ³ ) Dose ( mg/ kg/ day) MOE 1.08333 26 2.09E 57 1.37672 1.37672 0.0115 261 1.125 27 2.19E 57 1.37885 1.37885 0.0115 261 1.16667 28 2.29E 57 1.38062 1.38062 0.0115 261 1.20833 29 2.39E 57 1.38211 1.38211 0.0115 260 1.25 30 2.50E 57 1.38335 1.38335 0.0115 260 1.29167 31 2.60E 57 1.38439 1.38439 0.0115 260 1.33333 32 2.70E 57 1.38525 1.38525 0.0115 260 1.375 33 2.80E 57 1.38598 1.38598 0.0115 260 1.41667 34 2.90E 57 1.38658 1.38658 0.0116 260 1.45833 35 3.00E 57 1.38709 1.38709 0.0116 260 1.5 36 3.11E 57 1.38751 1.38751 0.0116 259 1.54167 37 3.21E 57 1.38786 1.38786 0.0116 259 1.58333 38 3.31E 57 1.38815 1.38815 0.0116 259 1.625 39 3.41E 57 1.3884 1.3884 0.0116 259 1.66667 40 3.51E 57 1.3886 1.3886 0.0116 259 1.70833 41 3.62E 57 1.38878 1.38878 0.0116 259 1.75 42 3.72E 57 1.38892 1.38892 0.0116 259 1.79167 43 3.82E 57 1.38904 1.38904 0.0116 259 1.83333 44 3.92E 57 1.38914 1.38914 0.0116 259 1.875 45 4.02E 57 1.38922 1.38922 0.0116 259 1.91667 46 4.13E 57 1.38929 1.38929 0.0116 259 1.95833 47 4.23E 57 1.38935 1.38935 0.0116 259 2 48 4.33E 57 1.38905 1.38905 0.0116 259 8 hr Average Exposure Concentration ( 0 to 8 hours) 0.637607 Exposure Time ( hr) 8 Inhalation ( m3/ hr) 0.5 BW ( kg) 60 Dose ( mg/ kg/ day) 0.042507 MOE 70.57635 Page 89 of 107 MCCEM SUMMARY REPORT TITLE: Humidifier  8hrs  child RUN Day Hour Min Length Days Hours Min Reporting TIME Start: 0 0 0 of Run: 2 0 0 Interval: 60 minutes HOUSE Type: Generic house State: NA Code: GN001 Season: SUMMER Zones: 2 Infiltration Rate: 0.18 ACH EMISSIONS Source Zone Type Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 1 Constant Emission Rate = 0.102 g/ hr 2 3 4 SINKS Sink Zone Model Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 2 3 4 5 6 ACTIVITIES Primary Activity Pattern is used on days: 1,2,3,4,5,6,7 OVERRIDE ACTIVITIES: YES DOSE Events/ yr: Yrs of Use: Weight( kg): 15 Length of Life( yrs):

MONTE CARLO: NO Number of Trials: 1 Seed No: Random OPTIONS Single Chamber: YES Saturation Concentration ( mg/ m ³ ) : NONE Output Concentration Units: mg/ m ³

Initial Concentrations Units: mg/ m ³

Zone 1: 0 Zone 2: 0 Zone 3: 0 Zone 4: 0 Outdoors: 0 ________________________________________________________________________ RESULTS ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ Page 90 of 107 LADD: 0.008613 mg/( kg day) LADC: 0.0067289 mg/ m ³ ADD: 0.008613 mg/( kg day) ADC: 0.0067289 mg/ m ³ Single Event Dose: 47.189 mg Peak Concentration: 1.3894 mg/ m ³ APDR: 1.7723 mg/( kg day) Time when APDR occurred: 1.9587 days Average Inhalation Rate: 19.2 m ³ / day ________________________________________________________________________

Humidifier  8hrs  child Time ( days) Time ( hours) Conc Outdoors ( mg/ m ³ ) Conc Zone 1 ( mg/ m ³ ) Conc@ Person( mg/ m ³ ) Dose ( mg/ kg/ day) MOE 0 0 0 0 0 0.0000 # DIV/ 0! 0.041667 1 8.65E 60 0.228802 0.228802 0.0122 246 0.083333 2 3.27E 59 0.419933 0.419933 0.0224 134 0.125 3 6.95E 59 0.579594 0.579594 0.0309 97 0.166667 4 1.17E 58 0.712968 0.712968 0.0380 79 0.208334 5 1.74E 58 0.824381 0.824381 0.0440 68 0.25 6 2.38E 58 0.917451 0.917451 0.0489 61 0.291667 7 3.08E 58 0.995197 0.995197 0.0531 57 0.333334 8 3.83E 58 1.06014 1.06014 0.0565 53 0.375 9 4.63E 58 1.11439 1.11439 0.0594 50 0.416667 10 5.47E 58 1.15971 1.15971 0.0619 49 0.458334 11 6.33E 58 1.19757 1.19757 0.0639 47 0.5 12 7.22E 58 1.2292 1.2292 0.0656 46 0.541667 13 8.14E 58 1.25561 1.25561 0.0670 45 0.583334 14 9.07E 58 1.27768 1.27768 0.0681 44 0.625 15 1.00E 57 1.29612 1.29612 0.0691 43 0.666667 16 1.10E 57 1.31152 1.31152 0.0699 43 0.708334 17 1.19E 57 1.32438 1.32438 0.0706 42 0.750001 18 1.29E 57 1.33513 1.33513 0.0712 42 0.791667 19 1.39E 57 1.3441 1.3441 0.0717 42 0.833334 20 1.49E 57 1.3516 1.3516 0.0721 42 0.875001 21 1.59E 57 1.35787 1.35787 0.0724 41 0.916667 22 1.69E 57 1.3631 1.3631 0.0727 41 0.958334 23 1.79E 57 1.36747 1.36747 0.0729 41 1 24 1.89E 57 1.37112 1.37112 0.0731 41 1.04167 25 1.99E 57 1.37417 1.37417 0.0733 41 1.08333 26 2.09E 57 1.37672 1.37672 0.0734 41 1.125 27 2.19E 57 1.37885 1.37885 0.0735 41 1.16667 28 2.29E 57 1.38062 1.38062 0.0736 41 1.20833 29 2.39E 57 1.38211 1.38211 0.0737 41 1.25 30 2.50E 57 1.38335 1.38335 0.0738 41 1.29167 31 2.60E 57 1.38439 1.38439 0.0738 41 1.33333 32 2.70E 57 1.38525 1.38525 0.0739 41 1.375 33 2.80E 57 1.38598 1.38598 0.0739 41 1.41667 34 2.90E 57 1.38658 1.38658 0.0740 41 1.45833 35 3.00E 57 1.38709 1.38709 0.0740 41 1.5 36 3.11E 57 1.38751 1.38751 0.0740 41 Page 91 of 107 Humidifier  8hrs  child Time ( days) Time ( hours) Conc Outdoors ( mg/ m ³ ) Conc Zone 1 ( mg/ m ³ ) Conc@ Person( mg/ m ³ ) Dose ( mg/ kg/ day) MOE 1.54167 37 3.21E 57 1.38786 1.38786 0.0740 41 1.58333 38 3.31E 57 1.38815 1.38815 0.0740 41 1.625 39 3.41E 57 1.3884 1.3884 0.0740 41 1.66667 40 3.51E 57 1.3886 1.3886 0.0741 41 1.70833 41 3.62E 57 1.38878 1.38878 0.0741 41 1.75 42 3.72E 57 1.38892 1.38892 0.0741 40 1.79167 43 3.82E 57 1.38904 1.38904 0.0741 40 1.83333 44 3.92E 57 1.38914 1.38914 0.0741 40 1.875 45 4.02E 57 1.38922 1.38922 0.0741 40 1.91667 46 4.13E 57 1.38929 1.38929 0.0741 40 1.95833 47 4.23E 57 1.38935 1.38935 0.0741 40 2 48 4.33E 57 1.38905 1.38905 0.0741 40 8 hr Average Exposure Concentration ( 0 to 8 hours) 0.637607 Exposure Time ( hr) 8 Inhalation ( m3/ hr) 0.8 BW ( kg) 15 Dose ( mg/ kg/ hr) 0.272046 MOE 11.02756 Page 92 of 107 MCCEM SUMMARY REPORT TITLE: Humidifier , 24 hr, Adult RUN Day Hour Min Length Days Hours Min Reporting TIME Start: 0 0 0 of Run: 2 0 0 Interval: 60 minutes HOUSE Type: Generic house State: NA Code: GN001 Season: SUMMER Zones: 2 Infiltration Rate: 0.18 ACH EMISSIONS Source Zone Type Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 1 Constant Emission Rate = 0.102 g/ hr 2 3 4 SINKS Sink Zone Model Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ 1 2 3 4 5 6 ACTIVITIES Primary Activity Pattern is used on days: 1,2,3,4,5,6,7 OVERRIDE ACTIVITIES: YES DOSE Events/ yr: Yrs of Use: Weight( kg): 60 Length of Life( yrs):

MONTE CARLO: NO Number of Trials: 1 Seed No: Random OPTIONS Single Chamber: YES Saturation Concentration ( mg/ m ³ ) : 0 Output Concentration Units: mg/ m ³

Initial Concentrations Units: g/ m ³

Zone 1: 0 Zone 2: 0 Zone 3: 0 Zone 4: 0 Outdoors: 0 ________________________________________________________________________ Page 93 of 107 RESULTS ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ LADD: 0.0014916 mg/( kg day) LADC: 0.0067289 mg/ m ³ ADD: 0.0014916 mg/( kg day) ADC: 0.0067289 mg/ m ³ Single Event Dose: 32.688 mg Peak Concentration: 1.3894 mg/ m ³ APDR: 0.30692 mg/( kg day) Time when APDR occurred: 1.9587 days Average Inhalation Rate: 13.3 m ³ / day ________________________________________________________________________

Humidifier , 24 hr, Adult Time ( days) Time ( hours) Conc Outdoors ( mg/ m ³ ) Conc Zone 1 ( mg/ m ³ ) Conc@ Person ( mg/ m ³ ) Dose ( mg/ kg/ day) MOE 0 0 0 0 0 0.0000 # DIV/ 0!

0.041667 1 8.65E 60 0.228802 0.228802 0.0021 1420 0.083333 2 3.27E 59 0.419933 0.419933 0.0039 774 0.125 3 6.95E 59 0.579594 0.579594 0.0054 561 0.166667 4 1.17E 58 0.712968 0.712968 0.0066 456 0.208334 5 1.74E 58 0.824381 0.824381 0.0076 394 0.25 6 2.38E 58 0.917451 0.917451 0.0085 354 0.291667 7 3.08E 58 0.995197 0.995197 0.0092 326 0.333334 8 3.83E 58 1.06014 1.06014 0.0098 306 0.375 9 4.63E 58 1.11439 1.11439 0.0103 292 0.416667 10 5.47E 58 1.15971 1.15971 0.0107 280 0.458334 11 6.33E 58 1.19757 1.19757 0.0111 271 0.5 12 7.22E 58 1.2292 1.2292 0.0113 264 0.541667 13 8.14E 58 1.25561 1.25561 0.0116 259 0.583334 14 9.07E 58 1.27768 1.27768 0.0118 254 0.625 15 1.00E 57 1.29612 1.29612 0.0120 251 0.666667 16 1.10E 57 1.31152 1.31152 0.0121 248 0.708334 17 1.19E 57 1.32438 1.32438 0.0122 245 0.750001 18 1.29E 57 1.33513 1.33513 0.0123 243 0.791667 19 1.39E 57 1.3441 1.3441 0.0124 242 0.833334 20 1.49E 57 1.3516 1.3516 0.0125 240 0.875001 21 1.59E 57 1.35787 1.35787 0.0125 239 0.916667 22 1.69E 57 1.3631 1.3631 0.0126 238 0.958334 23 1.79E 57 1.36747 1.36747 0.0126 238 1 24 1.89E 57 1.37112 1.37112 0.0127 237 1.04167 25 1.99E 57 1.37417 1.37417 0.0127 236 1.08333 26 2.09E 57 1.37672 1.37672 0.0127 236 1.125 27 2.19E 57 1.37885 1.37885 0.0127 236 1.16667 28 2.29E 57 1.38062 1.38062 0.0127 235 1.20833 29 2.39E 57 1.38211 1.38211 0.0128 235 1.25 30 2.50E 57 1.38335 1.38335 0.0128 235 1.29167 31 2.60E 57 1.38439 1.38439 0.0128 235 1.33333 32 2.70E 57 1.38525 1.38525 0.0128 235 1.375 33 2.80E 57 1.38598 1.38598 0.0128 234 Page 94 of 107 Humidifier , 24 hr, Adult Time ( days) Time ( hours) Conc Outdoors ( mg/ m ³ ) Conc Zone 1 ( mg/ m ³ ) Conc@ Person ( mg/ m ³ ) Dose ( mg/ kg/ day) MOE 1.41667 34 2.90E 57 1.38658 1.38658 0.0128 234 1.45833 35 3.00E 57 1.38709 1.38709 0.0128 234 1.5 36 3.11E 57 1.38751 1.38751 0.0128 234 1.54167 37 3.21E 57 1.38786 1.38786 0.0128 234 1.58333 38 3.31E 57 1.38815 1.38815 0.0128 234 1.625 39 3.41E 57 1.3884 1.3884 0.0128 234 1.66667 40 3.51E 57 1.3886 1.3886 0.0128 234 1.70833 41 3.62E 57 1.38878 1.38878 0.0128 234 1.75 42 3.72E 57 1.38892 1.38892 0.0128 234 1.79167 43 3.82E 57 1.38904 1.38904 0.0128 234 1.83333 44 3.92E 57 1.38914 1.38914 0.0128 234 1.875 45 4.02E 57 1.38922 1.38922 0.0128 234 1.91667 46 4.13E 57 1.38929 1.38929 0.0128 234 1.95833 47 4.23E 57 1.38935 1.38935 0.0128 234 2 48 4.33E 57 1.38905 1.38905 0.0128 234 24 hr Average Exposure Concentration ( 24 to 48 hours) 1.39 Exposure Time ( hr) 24 Inhalation ( m3/ hr) 0.554 BW ( mg/ kg/ day) 60 Dose ( kg) 0.307 MOE 9.770441 Page 95 of 107 MCCEM SUMMARY REPORT TITLE: Humidifier  24 hrs  Child RUN Day Hour Min Length Days Hours Min Reporting TIME Start: 0 0 0 of Run: 2 0 0 Interval: 60 minutes HOUSE Type: Generic house State: NA Code: GN001 Season: SUMMER Zones: 2 Infiltration Rate: 0.18 ACH EMISSIONS Source Zone Type Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 1 Constant Emission Rate = 0.102 g/ hr 2 3 4 SINKS Sink Zone Model Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 2 3 4 5 6 ACTIVITIES Primary Activity Pattern is used on days: 1,2,3,4,5,6,7 OVERRIDE ACTIVITIES: YES DOSE Events/ yr: Yrs of Use: Weight( kg): 15 Length of Life( yrs):

MONTE CARLO: NO Number of Trials: 1 Seed No: Random OPTIONS Single Chamber: YES Saturation Concentration ( mg/ m ³ ) : NONE Output Concentration Units: mg/ m ³

Initial Concentrations Units: mg/ m ³

Zone 1: 0 Zone 2: 0 Zone 3: 0 Zone 4: 0 Outdoors: 0 ________________________________________________________________________ Page 96 of 107 RESULTS ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ LADD: 0.0037233 mg/( kg day) LADC: 0.0067289 mg/ m ³ ADD: 0.0037233 mg/( kg day) ADC: 0.0067289 mg/ m ³ Single Event Dose: 20.399 mg Peak Concentration: 1.3894 mg/ m ³ APDR: 0.76614 mg/( kg day) Time when APDR occurred: 1.9587 days Average Inhalation Rate: 8.3 m ³ / day ________________________________________________________________________

Humidifier  24 hrs  Child Time ( days) Time ( hour s) Conc Outdoors ( mg/ m ³ ) Conc Zone 1 ( mg/ m ³ ) Conc@ Person ( mg/ m ³ ) Dose ( mg/ kg/ day) MOE 0 0 0 0 0 0.0000 # DIV/ 0! 0.041667 1 8.65E 60 0.228802 0.228802 0.0053 568 0.083333 2 3.27E 59 0.419933 0.419933 0.0097 310 0.125 3 6.95E 59 0.579594 0.579594 0.0134 224 0.166667 4 1.17E 58 0.712968 0.712968 0.0164 182 0.208334 5 1.74E 58 0.824381 0.824381 0.0190 158 0.25 6 2.38E 58 0.917451 0.917451 0.0212 142 0.291667 7 3.08E 58 0.995197 0.995197 0.0230 131 0.333334 8 3.83E 58 1.06014 1.06014 0.0245 123 0.375 9 4.63E 58 1.11439 1.11439 0.0257 117 0.416667 10 5.47E 58 1.15971 1.15971 0.0268 112 0.458334 11 6.33E 58 1.19757 1.19757 0.0276 109 0.5 12 7.22E 58 1.2292 1.2292 0.0284 106 0.541667 13 8.14E 58 1.25561 1.25561 0.0290 104 0.583334 14 9.07E 58 1.27768 1.27768 0.0295 102 0.625 15 1.00E 57 1.29612 1.29612 0.0299 100 0.666667 16 1.10E 57 1.31152 1.31152 0.0303 99 0.708334 17 1.19E 57 1.32438 1.32438 0.0305 98 0.750001 18 1.29E 57 1.33513 1.33513 0.0308 97 0.791667 19 1.39E 57 1.3441 1.3441 0.0310 97 0.833334 20 1.49E 57 1.3516 1.3516 0.0312 96 0.875001 21 1.59E 57 1.35787 1.35787 0.0313 96 0.916667 22 1.69E 57 1.3631 1.3631 0.0314 95 0.958334 23 1.79E 57 1.36747 1.36747 0.0315 95 1 24 1.89E 57 1.37112 1.37112 0.0316 95 1.04167 25 1.99E 57 1.37417 1.37417 0.0317 95 1.08333 26 2.09E 57 1.37672 1.37672 0.0318 94 1.125 27 2.19E 57 1.37885 1.37885 0.0318 94 1.16667 28 2.29E 57 1.38062 1.38062 0.0318 94 1.20833 29 2.39E 57 1.38211 1.38211 0.0319 94 1.25 30 2.50E 57 1.38335 1.38335 0.0319 94 1.29167 31 2.60E 57 1.38439 1.38439 0.0319 94 1.33333 32 2.70E 57 1.38525 1.38525 0.0320 94 Page 97 of 107 Humidifier  24 hrs  Child Time ( days) Time ( hour s) Conc Outdoors ( mg/ m ³ ) Conc Zone 1 ( mg/ m ³ ) Conc@ Person ( mg/ m ³ ) Dose ( mg/ kg/ day) MOE 1.375 33 2.80E 57 1.38598 1.38598 0.0320 94 1.41667 34 2.90E 57 1.38658 1.38658 0.0320 94 1.45833 35 3.00E 57 1.38709 1.38709 0.0320 94 1.5 36 3.11E 57 1.38751 1.38751 0.0320 94 1.54167 37 3.21E 57 1.38786 1.38786 0.0320 94 1.58333 38 3.31E 57 1.38815 1.38815 0.0320 94 1.625 39 3.41E 57 1.3884 1.3884 0.0320 94 1.66667 40 3.51E 57 1.3886 1.3886 0.0320 94 1.70833 41 3.62E 57 1.38878 1.38878 0.0320 94 1.75 42 3.72E 57 1.38892 1.38892 0.0320 94 1.79167 43 3.82E 57 1.38904 1.38904 0.0320 94 1.83333 44 3.92E 57 1.38914 1.38914 0.0320 94 1.875 45 4.02E 57 1.38922 1.38922 0.0320 94 1.91667 46 4.13E 57 1.38929 1.38929 0.0320 94 1.95833 47 4.23E 57 1.38935 1.38935 0.0320 94 2 48 4.33E 57 1.38905 1.38905 0.0320 94 24 hr Average Exposure Concentration ( 24 to 48 hours) 1.385182 Exposure Time ( hr) 24 Inhalation ( m3/ hr) 0.345833 BW ( kg) 15 Dose ( mg/ kg/ day) 0.766467 NOAEL ( mg/ kg// day) 3 MOE 3.9 Page 98 of 107 APPENDIX D: Input/ Output from Occupational MCCEM Modeling Food Processing Plant and Hatchery Page 99 of 107 MCCEM SUMMARY REPORT TITLE: Food Processing Plant NOTES: RUN Day Hour Min Length Days Hours Min Reporting TIME Start: 0 0 0 of Run: 2 0 0 Interval: 60 minutes HOUSE Type: Hypothetical house State: NA Code: HY06 Season: NA Zones: 1 Infiltration Rate: 0.18 ACH EMISSIONS Source Zone Type Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 2 3 4 SINKS Sink Zone Model Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 2 3 4 5 6 ACTIVITIES Primary Activity Pattern is used on days: 1,2,3,4,5,6,7 OVERRIDE ACTIVITIES: YES DOSE Events/ yr: Yrs of Use: Weight( kg): 60 Length of Life( yrs):

MONTE CARLO: NO Number of Trials: 1 Seed No: Random Page 100 of 107 OPTIONS Single Chamber: YES Saturation Concentration ( mg/ m ³ ) : NONE Output Concentration Units: mg/ m ³

Initial Concentrations Units: g/ m ³

Zone 1: 0.0441 Zone 2: 0 Zone 3: 0 Zone 4: 0 Outdoors: 0 ____________________________________________________________________________ RESULTS ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ LADD: 0.013961 mg/( kg day) LADC: 0.027923 mg/ m ³ ADD: 0.013961 mg/( kg day) ADC: 0.027923 mg/ m ³ Single Event Dose: 305.97 mg Peak Concentration: 44.034 mg/ m ³ APDR: 5.0326 mg/( kg day) Time when APDR occurred: 1.0003 days Average Inhalation Rate: 30 m ³ / day ___________________________________________________________________________ _

Food Processing Plant Time ( days) Time ( hours) Conc Outdoors ( mg/ m ³ ) Conc Zone 1 ( mg/ m ³ ) Conc@ Person( mg/ m ³ ) Dose ( mg/ kg/ day) MOE 0 0 0 44.1 0 0.735 4.081633 0.041667 1 1.09E 54 36.8354 36.8354 0.61392333 4.886604 0.083333 2 2.00E 54 30.7675 30.7675 0.51279167 5.850329 0.125 3 2.76E 54 25.6992 25.6992 0.42832 7.004109 0.166667 4 3.40E 54 21.4658 21.4658 0.35776333 8.385432 0.208334 5 3.93E 54 17.9297 17.9297 0.29882833 10.03921 0.25 6 4.37E 54 14.9761 14.9761 0.24960167 12.01915 0.291667 7 4.74E 54 12.5091 12.5091 0.208485 14.38952 0.333334 8 5.05E 54 10.4485 10.4485 0.17414167 17.22735 0.375 9 5.31E 54 8.72732 8.72732 0.14545533 20.62489 0.416667 10 5.52E 54 7.28967 7.28967 0.1214945 24.69248 0.458334 11 5.70E 54 6.08884 6.08884 0.10148067 29.56228 0.5 12 5.85E 54 5.08583 5.08583 0.08476383 35.39245 0.541667 13 5.98E 54 4.24804 4.24804 0.07080067 42.37248 0.583334 14 6.08E 54 3.54826 3.54826 0.05913767 50.72909 0.625 15 6.17E 54 2.96376 2.96376 0.049396 60.73366 0.666667 16 6.24E 54 2.47554 2.47554 0.041259 72.71141 0.708334 17 6.30E 54 2.06774 2.06774 0.03446233 87.05156 0.750001 18 6.36E 54 1.72712 1.72712 0.02878533 104.2197 0.791667 19 6.40E 54 1.44261 1.44261 0.0240435 124.7738 0.833334 20 6.43E 54 1.20497 1.20497 0.02008283 149.3813 0.875001 21 6.46E 54 1.00648 1.00648 0.01677467 178.8411 0.916667 22 6.49E 54 0.840681 0.840681 0.01401135 214.1121 0.958334 23 6.51E 54 0.702195 0.702195 0.01170325 256.3391 1 24 6.53E 54 0.586523 0.586523 0.00977538 306.8933 1.04167 25 6.54E 54 0.489905 0.489905 0.00816508 367.4182 1.08333 26 6.55E 54 0.409203 0.409203 0.00682005 439.8795 1.125 27 6.56E 54 0.341795 0.341795 0.00569658 526.6315 Page 101 of 107 Food Processing Plant Time ( days) Time ( hours) Conc Outdoors ( mg/ m ³ ) Conc Zone 1 ( mg/ m ³ ) Conc@ Person( mg/ m ³ ) Dose ( mg/ kg/ day) MOE 1.16667 28 6.57E 54 0.285491 0.285491 0.00475818 630.4927 1.20833 29 6.58E 54 0.238462 0.238462 0.00397437 754.8372 1.25 30 6.59E 54 0.19918 0.19918 0.00331967 903.7052 1.29167 31 6.59E 54 0.166369 0.166369 0.00277282 1081.932 1.33333 32 6.59E 54 0.138963 0.138963 0.00231605 1295.309 1.375 33 6.60E 54 0.116072 0.116072 0.00193453 1550.762 1.41667 34 6.60E 54 0.096951 0.096951 0.00161586 1856.6 1.45833 35 6.60E 54 0.080981 0.080981 0.00134968 2222.755 1.5 36 6.60E 54 0.067641 0.067641 0.00112735 2661.12 1.54167 37 6.61E 54 0.056498 0.056498 0.00094164 3185.937 1.58333 38 6.61E 54 0.047191 0.047191 0.00078652 3814.262 1.625 39 6.61E 54 0.039418 0.039418 0.00065696 4566.5 1.66667 40 6.61E 54 0.032924 0.032924 0.00054874 5467.103 1.70833 41 6.61E 54 0.027501 0.027501 0.00045834 6545.312 1.75 42 6.61E 54 0.022971 0.022971 0.00038284 7836.138 1.79167 43 6.61E 54 0.019187 0.019187 0.00031978 9381.596 1.83333 44 6.61E 54 0.016026 0.016026 0.0002671 11231.82 1.875 45 6.61E 54 0.013386 0.013386 0.0002231 13446.88 1.91667 46 6.61E 54 0.011181 0.011181 0.00018635 16098.88 1.95833 47 6.61E 54 0.009339 0.009339 0.00015565 19273.83 2 48 6.61E 54 0.007801 0.007801 0.00013001 23074.82 8 hr Average Exposure Concentration ( 0 to 8 hours) 23.85903 Exposure Time ( hr) 8 Inhalation ( m3/ hr) 1 BW ( kg) 60 Dose ( mg/ kg/ day) 3.181204 0 hr Re entry interval MOE 0.943039 8 hr Average Exposure Concentration ( 2 to 10 hours) 16.64588 Exposure Time ( hr) 8 Inhalation ( m3/ hr) 1 BW ( kg) 60 Dose ( mg/ kg/ day) 2.21945 2 hr Re entry interval MOE 1.351686 Page 102 of 107 MCCEM SUMMARY REPORT TITLE: Hatchery NOTES: RUN Day Hour Min Length Days Hours Min Reporting TIME Start: 0 0 0 of Run: 2 0 0 Interval: 60 minutes HOUSE Type: Hypothetical house State: NA Code: HY07 Season: NA Zones: 1 Infiltration Rate: 4 ACH EMISSIONS Source Zone Type Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 2 3 4 SINKS Sink Zone Model Details ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯

1 2 3 4 5 6 ACTIVITIES Primary Activity Pattern is used on days: 1,2,3,4,5,6,7 OVERRIDE ACTIVITIES: YES DOSE Events/ yr: Yrs of Use: Weight( kg): 60 Length of Life( yrs):

MONTE CARLO: NO Number of Trials: 1 Seed No: Random OPTIONS Single Chamber: YES Saturation Concentration ( mg/ m ³ ) : NONE Output Concentration Units: mg/ m ³

Initial Concentrations Units: g/ m ³ Zone 1: 0.394 Zone 2: 0 Zone 3: 0 Zone 4: 0 Outdoors: 0 RESULTS ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ ¯ LADD: 0.0055252 mg/( kg day) LADC: 0.01105 mg/ m ³ ADD: 0.0055252 mg/( kg day) ADC: 0.01105 mg/ m ³ Single Event Dose: 121.08 mg Peak Concentration: 381.08 mg/ m ³ Page 103 of 107 APDR: 2.0181 mg/( kg day) Time when APDR occurred: 0.41701 days Average Inhalation Rate: 30 m ³ / day Hatchery Time ( days) Time ( hours) Conc Outdoors ( mg/ m ³ ) Conc Zone 1 ( mg/ m ³ ) Conc@ Person ( mg/ m ³ ) Dose ( mg/ kg/ day) MOE 0 0 0 394 0 6.5667 0.45685279 0.041667 1 5.80E 53 7.21634 7.21634 0.1203 25 0.083333 2 5.91E 53 0.132171 0.132171 0.0022 1362 0.125 3 5.91E 53 0.002421 0.002421 0.0000 74356 0.166667 4 5.91E 53 4.43E 05 4.43E 05 0.0000 4.06E+ 06 0.208334 5 5.91E 53 8.12E 07 8.12E 07 0.0000 2.22E+ 08 0.25 6 5.91E 53 1.49E 08 1.49E 08 0.0000 1.21E+ 10 0.291667 7 5.91E 53 2.72E 10 2.72E 10 0.0000 6.61E+ 11 0.333334 8 5.91E 53 4.99E 12 4.99E 12 0.0000 3.61E+ 13 0.375 9 5.91E 53 9.14E 14 9.14E 14 0.0000 1.97E+ 15 0.416667 10 5.91E 53 1.67E 15 1.67E 15 0.0000 1.08E+ 17 0.458334 11 5.91E 53 3.07E 17 3.07E 17 0.0000 5.87E+ 18 0.5 12 5.91E 53 5.61E 19 5.61E 19 0.0000 3.21E+ 20 0.541667 13 5.91E 53 1.03E 20 1.03E 20 0.0000 1.75E+ 22 0.583334 14 5.91E 53 1.88E 22 1.88E 22 0.0000 9.56E+ 23 0.625 15 5.91E 53 3.45E 24 3.45E 24 0.0000 5.22E+ 25 0.666667 16 5.91E 53 6.32E 26 6.32E 26 0.0000 2.85E+ 27 0.708334 17 5.91E 53 1.16E 27 1.16E 27 0.0000 1.56E+ 29 0.750001 18 5.91E 53 2.12E 29 2.12E 29 0.0000 8.49E+ 30 0.791667 19 5.91E 53 3.88E 31 3.88E 31 0.0000 4.64E+ 32 0.833334 20 5.91E 53 7.11E 33 7.11E 33 0.0000 2.53E+ 34 0.875001 21 5.91E 53 1.30E 34 1.30E 34 0.0000 1.38E+ 36 0.916667 22 5.91E 53 2.39E 36 2.39E 36 0.0000 7.55E+ 37 0.958334 23 5.91E 53 4.37E 38 4.37E 38 0.0000 4.12E+ 39 1 24 5.91E 53 8.00E 40 8.00E 40 0.0000 2.25E+ 41 1.04167 25 5.91E 53 1.47E 41 1.47E 41 0.0000 1.23E+ 43 1.08333 26 5.91E 53 2.68E 43 2.68E 43 0.0000 6.71E+ 44 1.125 27 5.91E 53 4.92E 45 4.92E 45 0.0000 3.66E+ 46 1.16667 28 5.91E 53 9.00E 47 9.00E 47 0.0000 2.00E+ 48 1.20833 29 5.91E 53 1.65E 48 1.65E 48 0.0000 1.09E+ 50 1.25 30 5.91E 53 3.03E 50 3.03E 50 0.0000 5.95E+ 51 1.29167 31 5.91E 53 6.12E 52 6.12E 52 0.0000 2.94E+ 53 1.33333 32 5.91E 53 6.92E 53 6.92E 53 0.0000 2.60E+ 54 1.375 33 5.91E 53 5.93E 53 5.93E 53 0.0000 3.04E+ 54 1.41667 34 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 1.45833 35 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 1.5 36 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 1.54167 37 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 1.58333 38 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 1.625 39 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 1.66667 40 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 1.70833 41 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 1.75 42 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 1.79167 43 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 Page 104 of 107 Hatchery Time ( days) Time ( hours) Conc Outdoors ( mg/ m ³ ) Conc Zone 1 ( mg/ m ³ ) Conc@ Person ( mg/ m ³ ) Dose ( mg/ kg/ day) MOE 1.83333 44 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 1.875 45 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 1.91667 46 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 1.95833 47 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 2 48 5.91E 53 5.91E 53 5.91E 53 0.0000 3.05E+ 54 8 hr Average Exposure Concentration ( 0 to 8 hours) 44.59455 Exposure Time ( hr) 8 Inhalation Rate ( m3/ hr) 1 BW ( kg) 60 Dose ( mg/ kg/ day) 5.94594 0 hr Re entry interval MOE 0.504546 8 hr Average Exposure Concentration ( 2 to 10 hours) 0.01496 Exposure Time ( hr) 8 Inhalation Rate ( m3/ hr) 1 BW ( kg) 60 Dose ( mg/ kg/ day) 0.001995 2 hr Re entry interval MOE 1504.045 Page 105 of 107 APPENDIX E: Calculation of DDAC Unit Exposure Values Page 106 of 107 Table E 1: DDAC Dermal and Inhalation Exposure Values for Chemical Operators, Graders, Millwrights, Clean up Crews, and Trim Saw Operatorsa Chemical Operator Grader Trim Saw Operator Millwright Cleanup Crew Dermal Inhalation Dermal Inhalation Dermal Inhalation Dermal Inhalation Dermal Inhalation Replicate Number Potential exposure ( mg) Air Concentrationb,

c (: g/ m3) Potential exposured ( mg) Potential exposure ( mg) Air Concentration b, c (: g/ m3) Potential exposure d ( mg) Potential exposure ( mg) Air Concentration b, c (: g/ m3) Potential exposure d ( mg) Potential exposure ( mg) Air Concentration b, c (: g/ m3) Potential exposure d ( mg) Potential exposure ( mg) Air Concentration b, c (: g/ m3) Potential exposure d ( mg)

1 3.5 10.1 0.0808 3.05 2.90 0.0232 0.78 2.83 0.0227 1.31 2.92 0.0233 68.3 2.99145 0.0239 2 6.11 2.80 0.0224 7.47 2.93 0.0234 1.98 12.3 0.0984 29.08 2.83 0.0226 0.720 2.78840 0.0223 3 6.07 2.79 0.0223 1.09 2.91 0.0233 8.03 15.6 0.1248 166 30.3 0.2424 4 46.37 2.82 0.0226 10.51 3.00 0.0240 95.2 412 3.2960 5 0.94 2.93 0.0235 0.61 2.82 0.0226 1.20 2.83585 0.0227 6 22.15 2.83 0.0227 0.98 2.85 0.0228 0.260 2.80989 0.0225 7 21.45 2.77 0.0222 2.63 2.91 0.0233 8 0.22 2.73 0.0218 5.23 2.85 0.0228 9 0.44 2.77 0.0222 0.19 13.20 0.1056 10 0.33 3.14 0.0251 1.47 2.89 0.0231 11 0.29 2.88 0.0230 2.38 2.85 0.0228 12 4.09 2.81 0.0225 13 1.03 2.94 0.0235 Arithmetic Mean 9.81 3.51 0.0281 3.13 3.68 0.0295 1.38 7.57 0.061 12.8 7.12 0.057 55.3 75.6 0.60 Minimum 0.22 2.73 0.0218 0.19 2.81 0.0225 0.78 2.83 0.0227 1.31 2.83 0.0226 0.260 2.79 0.0223 Maximum 46.4 10.1 0.081 10.51 13.2 0.106 1.98 12.3 0.098 29.1 15.6 0.125 166 412 3.30 a. " Measurement and Assessment of Dermal and Inhalation Exposures to Didecyl Dimethyl Ammonium Chloride ( DDAC) Used in the Protection of Cut Lumber ( Phase III)" is the study that values were obtained from for this table ( Bestari et al., 1999, MRID 455243 04).

b. The inhalation LOD was not provided for chemical operators, graders, trim saw operators, millwrights, or the clean up crew. Therefore, the LOD provided for the diptank operator ( 5.6 : g)

was used for these positions. Residues less than the LOD were adjusted to 1/ 2 LOD.

c. The inhalation limit of detection was converted to : g/ m3 using the following equation: air concentration (: g/ m3) = 5.6 : g/ [ average flow rate ( L/ min) * sampling duration ( 480 min) * 1000 L/ m3. Data was obtained from Bestari et al ( 1999).

d. DDAC air concentrations were converted to inhalation exposure using the following equation: Air concentration (: g/ m3) x inhalation rate ( 1.0 m3/ hr) x Conversion factor ( 1 mg/ 1000 : g) x sample duration ( 8 hours/ day Page 107 of 107 Table E 2: Normalization of DDAC Dermal and Inhalation Exposure Values for Diptank Operatorsa Worker ID Mill number Sample Time ( min) DDAC Conc. in Diptank (%) Gloves Dermal Body Exposureb ( mg) Hand Exposureb ( mg) Total Dermal Exposure ( mg) Normalized Total Dermal Unit Exposurec ( mg/ 1 % solution) Air Conc. d ( mg/ m3) Inhalation Exposuree ( mg) Normalized Inhalation Unit Exposurec ( mg / 1% solution)

M7P1A 7 480 0.64 Rubber 0.5 3.44 3.94 6.16 0.003 0.024 0.0375 M7P1B 7 480 0.64 Rubber 0.32 2.02 2.34 3.66 0.003 0.024 0.0375 M8P4A 8 408 0.42 Rubber 0.04f 1.34 1.38 3.29 0.003 0.024 0.057 M8P4B 8 480 0.42 Rubber 0.04f 0.5 0.54 1.29 0.003 0.024 0.057 M8P7 8 480 0.42 Cotton 0.03 0.04 0.07 0.17 0.003 0.024 0.057 M11P9A 11 395 0.63 Leather 0.15 3.33 3.48 5.52 0.003 0.024 0.0381 M11P9B 11 480 0.63 Leather 0.1 0.45 0.55 0.87 0.003 0.024 0.0381 Arithmetic Mean 0.17 1.59 1.76 2.99 0.0030 0.0240 0.046 Standard Deviation 0.18 1.39 1.53 2.32 0.0000 0.0000 0.0103 Median 0.10 1.34 1.38 3.29 0.0030 0.0240 0.0381 Geometric Mean 0.10 0.83 0.99 1.86 0.0030 0.0240 0.045 90% tile 0.39 3.37 3.66 5.78 0.0030 0.0240 0.057 Maximum 0.50 3.44 3.94 6.16 0.0030 0.0240 0.057 a. " Measurement and Assessment of Dermal and Inhalation Exposures to Didecyl Dimethyl Ammonium Chloride ( DDAC) Used in the Protection of Cut Lumber ( Phase III)" is the study that values were obtained from for this table ( Bestari et al., 1999, MRID 455243 04).

b. DDAC concentration that was detected in the monitoring study ( MRID # 455243 04).

c. Normalization of DDAC data for percent ai treatment. Normalized Unit Exposure ( mg/ 1% ai solution) = Exposure ( mg DDAC) / concentration in diptank solution (% DDAC)

d. All inhalation residues were < LOD ( 5.6

g or 0.0056 mg/ m3). 1/ 2 LOD was used in all calculations ( 0.003 mg/ m3). Air Concentration ( mg/ m3) = 5.6

g / (~ 2 L/ min flow rate x ~ 480 min) x 1000 L/ m3 conversion x 0.001

g/ mg = 0.003 mg/ m3 e. Inhalation exposure ( mg) = air concentration ( mg/ m3) x inhalation rate ( 1.0 m3/ hr) x sample duration ( 8 hours/ day).

f. Residues were < LOD for dermal samples M8P4A, M8P4B. Sample size of ~ 11,231 cm2 x < 0.007 ug/ cm2 = LOD of 0.079 mg. 1/ 2 LOD reported ( i. e., 0.04 mg)