S.D.	0.30	0.21

	IGL876	M	3.77	3.99	4.97	4.91	5.08	5.12	5.33	4.61	5.18

	69.38

Mean	4.77	4.40

	IGL876	F	4.76	1.96	4.72	4.69	5.08	5.21

S.D.	0.55	1.22

	IGL880	M	5.80	6.03	6.08	5.48	5.57	5.64	6.11	5.99	6.11

	87.14

Mean	5.87	5.72

	IGL880	F	5.49	5.49	5.52	5.83	6.12	5.88

S.D.	0.25	0.26

	IGL894	M	5.79	5.90	6.04	5.81	6.02	5.99	5.86

	84.81

Mean	5.92	5.43

	IGL894	F	5.51	5.66	5.47	5.17	5.48	5.62	5.11	5.38

S.D.	0.10	0.20

	IGL902	M	5.41	5.66	5.80	5.51	5.44	5.21	4.73

	79.53

Mean	5.39	5.22

	IGL902	F	5.01	5.30	5.41	5.07	5.24	5.11	5.27	5.36

S.D.	0.35	0.14

	IGL891	M	5.26	5.15	5.07	5.02	4.87	5.01	5.00	4.87	5.22	5.38

85.76

Mean	5.09	4.99

	IGL891	F	4.80	5.08	5.26	5.20	4.73	4.96	4.88

	S.D.	0.17	0.20

	IGL901	M	5.38	5.12	5.01	5.41	5.38

	87.14

Mean	5.26	5.07

	IGL901	F	5.11	4.90	4.99	5.09	5.16	5.03	5.14	5.13	5.34	5.03	4.99	4.93

S.D.	0.18	0.12

	IGL904	M	5.75	5.63	5.43	5.82	5.64	5.20	5.43	4.70	5.57	5.23	5.33	5.29

102.59

Mean	5.42	5.37

	IGL904	F	5.00	5.48	5.69	5.44	5.42	5.43	5.11

	S.D.	0.30	0.23

	IGL910	M	4.94	5.65	5.43	5.45	5.82	5.58	5.86	5.99

81.94

Mean	5.59	5.32

	IGL910	F	4.98	5.30	5.78	5.18	5.55	5.20	5.23

	S.D.	0.33	0.27

	IGL933	M	5.59	5.84	6.22	5.82	6.42	6.01

64.28

Mean	5.98	5.68

	IGL933	F	5.49	5.67	5.55	5.93	5.74

	S.D.	0.30	0.17

	IGL956	M	5.68	5.46	5.70	5.76	4.05	5.88	5.57	5.33	5.38

	75.84

Mean	5.42	5.41

	IGL956	F	5.75	5.28	5.57	5.52	4.91

	S.D.	0.55	0.32

G-2

APPENDIX G - INDIVIDUAL AND MEAN FETAL BODY WEIGHT AND LITTER WEIGHTS

(GRAMS)

TARGET DOSE: 0 MG/M3

ANIMAL

	Litter Weights	Fetus Weight

	NUMBER 	SEX

Litter

	Males	Females

	IGL920	M	5.70	5.44	4.97	5.60	5.73	5.23

82.39

Mean	5.45	4.97

	IGL920	F	4.59	5.18	4.85	5.12	4.90	5.13	5.30	4.44	5.29	4.92

S.D.	0.30	0.29

	IGL931	M	4.88	5.16	5.16	5.47	4.97	4.77	5.11	4.91	4.80

	64.44

Mean	5.03	4.80

	IGL931	F	4.29	4.78	5.33	4.81

S.D.	0.22	0.42

	IGL953	M	5.30	5.50	5.59	5.49	5.92	5.75	5.25	5.39	5.31	5.19

94.66

Mean	5.47	5.00

	IGL953	F	4.75	4.78	4.89	5.00	5.15	5.28	5.42	4.70

S.D.	0.23	0.26

	IGL869	M	5.32	5.17	5.18	5.25	5.15	5.73	5.72	5.70

72.70

Mean	5.40	4.91

	IGL869	F	4.99	5.09	4.99	4.60	4.77	5.04

S.D.	0.27	0.19

	IGL921	M	5.31	5.33	5.47	5.33	5.46	5.27

77.92

Mean	5.36	5.08

	IGL921	F	5.48	5.22	4.98	4.79	4.91	5.12	4.90	4.91	5.44

	S.D.	0.08	0.25

	IGL928	M	5.15	4.40	5.00	5.35	5.29	5.53	5.84	5.38

73.50

Mean	5.24	5.26

	IGL928	F	5.11	5.09	5.61	5.22	5.15	5.38

S.D.	0.42	0.20

	IGL952	M	5.31	5.80	5.58	5.16	5.44	5.50	5.31	5.46

75.03

Mean	5.45	5.25

	IGL952	F	4.84	5.45	5.12	5.20	5.41	5.45

S.D.	0.19	0.24

	IGL957	M	5.54	5.87	5.82	5.60

86.24

Mean	5.71	5.28

	IGL957	F	5.04	5.22	5.27	5.19	5.15	5.13	5.85	5.97	5.29	5.19	5.17	4.94

S.D.	0.16	0.31

	IGL988	M	5.76	5.63	5.94	3.76	5.73	5.99	6.46	5.74

85.34

Mean	5.63	5.76

	IGL988	F	5.35	5.77	5.84	5.50	6.39	5.76	5.72

	S.D.	0.80	0.33

	IGL969	M	4.78	4.91	4.92	4.98	4.99	4.84	4.92	5.05

82.50

Mean	4.92	4.79

	IGL969	F	4.39	4.59	5.17	4.48	5.20	4.62	4.94	4.87	4.85

	S.D.	0.09	0.29

	NOTE: NP- NOT PREGNANT

G-3

APPENDIX G - INDIVIDUAL AND MEAN FETAL BODY WEIGHT AND LITTER WEIGHTS

(GRAMS)

TARGET DOSE: 2000 MG/M3

ANIMAL

	Litter Weights	Fetus Weight

	NUMBER 	SEX

Litter

	Males	Females

	IGL889	M	5.89	5.99	5.76	6.14	5.70	5.93	5.48	5.84

78.76

Mean	5.84	5.34

	IGL889	F	4.86	5.53	5.74	5.83	4.86	5.21

S.D.	0.20	0.43

	IGL893	M	6.08	5.89	4.56	5.76	6.07	5.45	5.36	5.72	5.46

	93.84

Mean	5.59	5.44

	IGL893	F	5.64	5.47	4.96	5.34	5.38	5.57	5.67	5.46

S.D.	0.47	0.23

	IGL885	M	5.81	5.60	5.92	5.59	4.59	5.41

76.56

Mean	5.49	5.46

	IGL885	F	5.78	5.59	5.05	5.36	5.72	5.67	5.05	5.42

S.D.	0.47	0.29

	IGL890	M	5.47	5.39	5.63	5.73	5.68	5.97	5.55	5.56

81.50

Mean	5.62	5.22

	IGL890	F	5.54	5.35	5.55	5.04	5.02	4.70	5.32

	S.D.	0.18	0.31

	IGL863	M	5.30	5.73	5.48

	81.63

Mean	5.50	5.01

	IGL863	F	5.00	5.34	5.08	4.77	5.33	4.86	5.19	5.04	5.02	4.91	4.92	4.84 4.82

	S.D.	0.22	0.19

	IGL878	M	5.34	5.74	5.39	5.77	5.17	5.42	5.13	5.58	5.29	5.60	5.97

	85.51

Mean	5.49	5.02

	IGL878	F	4.84	5.46	5.07	5.02	4.72

	S.D.	0.26	0.28

	IGL882	M	5.38	5.59	5.03	5.18	5.52	5.28

80.82

Mean	5.33	4.88

	IGL882	F	5.05	5.11	4.80	5.06	4.72	4.91	4.57	4.61	5.14	4.87

S.D.	0.21	0.21

	IGL911	M	5.07	5.45	5.47	5.63	5.50

	71.88

Mean	5.42	4.97

	IGL911	F	5.21	5.51	2.65	5.39	5.39	5.27	5.12	4.91	5.31

	S.D.	0.21	0.89

	IGL868	M	5.18	5.37	5.58	5.77	5.12	5.46

71.66

Mean	5.41	4.90

	IGL868	F	5.45	5.15	5.16	5.22	4.40	4.82	4.32	4.66

S.D.	0.24	0.41

	IGL912	M	5.25	5.18	5.58	5.43	5.11	5.18	5.28	5.22

76.83

Mean	5.28	4.94

	IGL912	F	4.53	5.28	4.85	5.01	4.95	5.13	4.85

	S.D.	0.15	0.24

	IGL913	M	5.72	5.72	5.99	5.27	5.62

	60.64

Mean	5.66	5.39

	IGL913	F	5.09	5.65	5.57	5.12	5.16	5.73

S.D.	0.26	0.29

	IGL925	M	5.50	5.39	5.52	5.52	5.57	5.00

68.75

Mean	5.42	5.18

	IGL925	F	5.13	5.37	5.06	5.20	5.49	5.06	4.94

	S.D.	0.21	0.19

	   IGL944 NP

	   IGL944NP

	IGL871	M	5.44	5.22	5.07	6.02	5.45	5.74	5.60	5.25

59.16

Mean	5.47	5.12

	IGL871	F	5.05	5.30	5.02

	S.D.	0.31	0.15

	IGL922	M	5.51	5.50	5.79	5.56	5.76	5.50	5.78

	81.86

Mean	5.63	5.31

	IGL922	F	5.11	5.32	5.18	5.08	5.45	5.36	5.31	5.65

S.D.	0.14	0.19

G-4

APPENDIX G - INDIVIDUAL AND MEAN FETAL BODY WEIGHT AND LITTER WEIGHTS

(GRAMS)

TARGET DOSE: 2000 MG/M3

ANIMAL

	Litter Weights	Fetus Weight

	NUMBER 	SEX

Litter

	Males	Females

	IGL951	M	5.49	5.19	5.49	5.66	5.33	5.35	5.56

	80.74

Mean	5.44	5.33

	IGL951	F	5.30	5.51	5.30	5.59	5.34	5.31	5.28	5.04

S.D.	0.16	0.16

	IGL859	M	5.64	5.75	5.66	6.06	5.58	5.38

66.02

Mean	5.68	5.33

	IGL859	F	5.51	5.46	5.24	5.57	5.27	4.90

S.D.	0.22	0.25

	IGL943	M	5.52	5.64	4.67	5.39	5.20

	68.12

Mean	5.28	5.21

	IGL943	F	5.31	5.27	5.38	5.34	5.02	5.14	5.05	5.19

S.D.	0.38	0.13

	IGL948	M	5.79	5.83	6.39	5.61	5.85	6.08	5.36

	86.40

Mean	5.84	5.69

	IGL948	F	5.26	5.61	5.85	5.52	5.95	5.84	5.87	5.59

S.D.	0.33	0.23

	IGL974	M

4.66

Mean

4.66

	IGL974	F	4.66

	S.D.

	IGL888	M	5.00	5.76	5.38	5.22	6.02

	80.85

Mean	5.48	5.35

	IGL888	F	5.41	5.32	5.85	5.44	5.29	4.86	5.13	5.31	5.43	5.43

S.D.	0.41	0.25

	IGL976	M	5.32	5.15	4.79

	25.45

Mean	5.09	5.10

	IGL976	F	5.09	5.10

S.D.	0.27	0.01

	IGL923	M	5.72	5.32	3.81	5.63

60.72

Mean	5.12	5.03

	IGL923	F	4.94	5.39	5.02	5.19	5.05	5.34	5.46	3.85

S.D.	0.89	0.51

	IGL924	M	5.59	5.42	4.78

	67.67

Mean	5.26	5.19

	IGL924	F	5.40	5.32	5.40	5.21	5.16	4.47	5.00	5.33	5.44	5.15

S.D.	0.43	0.29

	   IGL905 NP

	   IGL905 NP

	NOTE: NP- NOT PREGNANT

G-5

APPENDIX G - INDIVIDUAL AND MEAN FETAL BODY WEIGHT AND LITTER WEIGHTS

(GRAMS)

TARGET DOSE: 10,000 MG/M3

ANIMAL

	Litter Weights	Fetus Weight

	NUMBER 	SEX

Litter

	Males	Females

	IGL870	M	5.64	5.42	5.57	5.38	5.15	5.55

63.34

Mean	5.45	5.11

	IGL870	F	5.03	4.90	5.24	5.17	5.07	5.22

S.D.	0.18	0.13

	IGL875	M	5.08	5.23	5.64	5.39	5.00	5.23	5.72	5.38	5.42	5.39	4.84

	83.52

Mean	5.30	5.04

	IGL875	F	5.04	5.18	4.94	4.88	5.16

	S.D.	0.26	0.13

	IGL862	M	5.30	6.05	5.86	6.06

61.86

Mean	5.82	5.51

	IGL862	F	5.66	5.42	5.66	5.71	5.30	5.42	5.42

	S.D.	0.36	0.16

	IGL858	M	4.97	4.65	5.10	5.03	5.40	5.03

74.46

Mean	5.03	4.92

	IGL858	F	5.00	4.77	4.79	4.78	4.77	4.96	5.24	4.90	5.07

	S.D.	0.24	0.16

	IGL883	M	4.88	4.99	5.21	4.76	5.02

	78.10

Mean	4.97	4.84

	IGL883	F	4.49	4.79	4.81	4.73	4.85	4.73	5.17	5.11	4.97	4.59	5.00

	S.D.	0.17	0.21

	IGL896	M	5.41	5.32	5.26	5.54	5.72	5.51	5.27	5.48	5.91	5.65

75.99

Mean	5.51	5.23

	IGL896	F	5.16	5.29	5.11	5.36

S.D.	0.21	0.12

	IGL906	M	5.56	5.60	5.98	5.44	5.43	5.67	5.88

	77.22

Mean	5.65	5.38

	IGL906	F	5.49	5.26	5.66	5.12	5.57	5.47	5.09

	S.D.	0.21	0.22

	IGL861	M	5.72	5.08	5.33	5.37	2.55

	73.26

Mean	4.81	5.47

	IGL861	F	5.04	5.38	5.80	5.75	5.09	5.42	5.64	5.39	5.70

	S.D.	1.28	0.28

	IGL903	M	5.52	5.52	5.38	5.57	5.32	5.19	5.39

	83.52

Mean	5.41	5.07

	IGL903	F	5.07	5.12	5.01	5.27	5.10	4.94	5.00	4.87	5.25

	S.D.	0.13	0.13

	IGL914	M	5.18	5.44	5.82	5.71	5.80	5.53	5.79	5.46

76.84

Mean	5.59	5.35

	IGL914	F	5.22	5.26	5.50	5.30	5.39	5.44

S.D.	0.23	0.11

	IGL918	M	5.63	5.79	5.44	5.18	5.65	5.39	5.12	5.10	5.55

	74.17

Mean	5.43	5.06

	IGL918	F	4.52	5.38	5.29	4.97	5.16

	S.D.	0.25	0.34

	IGL907	M	6.18	5.36	5.77	5.24	5.58	5.72

85.71

Mean	5.64	5.19

	IGL907	F	5.04	5.60	5.09	5.19	5.37	5.03	4.98	4.99	5.14	5.43

S.D.	0.33	0.21

	IGL909	M	4.36	5.06	5.17	5.66	5.58	4.94

81.48

Mean	5.13	5.07

	IGL909	F	4.59	5.12	5.22	4.99	5.24	5.19	5.50	4.72	5.04	5.10

S.D.	0.47	0.26

	IGL946	M	5.35	5.09	5.38	5.04	5.63	5.43	5.49	5.24	4.90	5.36

77.80

Mean	5.29	4.98

	IGL946	F	5.22	5.08	4.82	4.61	5.16

	S.D.	0.22	0.26

	IGL954	M	6.11	5.58	5.83	6.07	5.83	5.27

82.44

Mean	5.78	5.31

	IGL954	F	5.44	5.50	5.51	5.38	3.45	5.55	5.80	5.49	5.63

	S.D.	0.32	0.71

G-6

APPENDIX G - INDIVIDUAL AND MEAN FETAL BODY WEIGHT AND LITTER WEIGHTS

(GRAMS)

TARGET DOSE: 10,000 MG/M3

ANIMAL

	Litter Weights	Fetus Weight

	NUMBER 	SEX

Litter

	Males	Females

	IGL955	M	5.43	4.81	5.40	5.44	5.67

	67.58

Mean	5.35	5.10

	IGL955	F	5.02	5.28	4.82	5.12	4.72	4.89	5.33	5.65

S.D.	0.32	0.31

	IGL934	M	5.33	5.81	5.76	5.45	5.77	5.20	4.98	5.41	5.49	5.79

75.30

Mean	5.50	5.08

	IGL934	F	4.90	5.16	5.42	4.83

S.D.	0.28	0.27

	   IGL973 NP

	   IGL973 NP

	IGL881	M	5.53	5.73	5.19	5.29

75.29

Mean	5.44	5.36

	IGL881	F	4.89	5.05	5.70	5.84	5.29	5.52	5.46	5.26	5.29	5.25

S.D.	0.24	0.28

	IGL917	M	4.94	4.93	4.60	4.81	5.08	5.03	5.37	4.95

77.94

Mean	4.96	4.78

	IGL917	F	4.48	4.95	4.96	4.98	4.77	5.02	4.49	4.58

S.D.	0.22	0.23

	IGL940	M	5.78	5.92	5.83	6.18	5.95	6.17

53.40

Mean	5.97	5.86

	IGL940	F	5.75	5.89	5.93

	S.D.	0.17	0.09

	IGL963	M	5.83	5.82	5.64	5.43	5.57	5.52	5.92

	72.02

Mean	5.68	5.38

	IGL963	F	5.45	5.46	5.20	5.46	5.39	5.33

S.D.	0.18	0.10

	   IGL983 NP

	   IGL983 NP

	IGL972	M	5.43	5.78	5.93	5.49	5.69	5.37	5.80

	66.02

Mean	5.64	5.31

	IGL972	F	5.31	5.49	5.19	5.24	5.30

	S.D.	0.21	0.11

	IGL895	M	4.94	5.02	5.14	5.20	5.85	5.53	5.69	5.54	5.64	4.88	3.42

	92.67

Mean	5.17	5.12

	IGL895	F	5.15	4.92	5.22	4.90	5.34	5.21	5.08

	S.D.	0.67	0.16

	NOTE: NP- NOT PREGNANT

G-7

APPENDIX G - INDIVIDUAL AND MEAN FETAL BODY WEIGHT AND LITTER WEIGHTS

(GRAMS)

TARGET DOSE: 20,000 MG/M3

ANIMAL

	Litter Weights	Fetus Weight

	NUMBER 	SEX

Litter

	Males	Females

	IGL866	M	6.04	6.29	6.19	6.06	5.80

	69.71

Mean	6.08	5.62

	IGL866	F	5.58	6.00	5.61	5.88	4.79	5.89	5.58

	S.D.	0.18	0.40

	IGL892	M	5.56	5.37	5.46	5.29	5.64	5.29	5.25	5.30	5.42

	78.99

Mean	5.40	5.07

	IGL892	F	4.55	5.73	5.06	5.03	5.06	4.98

S.D.	0.13	0.38

	IGL864	M	5.00	5.24	4.98	5.38	5.46	5.17	5.35	5.58

62.27

Mean	5.27	5.03

	IGL864	F	5.17	5.05	5.10	4.79

S.D.	0.21	0.17

	IGL872	M	4.86	4.84	4.99	4.67	3.53

	74.02

Mean	4.58	4.65

	IGL872	F	4.32	4.72	4.73	4.66	4.73	4.30	4.70	4.39	5.08	4.88	4.62

	S.D.	0.60	0.24

	IGL873	M	5.55	5.77	5.45	5.86

70.15

Mean	5.66	5.28

	IGL873	F	5.27	5.21	5.16	5.36	5.37	5.70	5.16	5.28	5.01

	S.D.	0.19	0.19

	IGL879	M	4.68	4.87	4.91	5.09	5.10	5.02	4.73	4.58	4.66

	96.13

Mean	4.85	4.37

	IGL879	F	4.18	4.20	4.70	4.31	4.61	4.35	4.08	4.35	4.53	4.44	4.32	4.42

S.D.	0.20	0.18

	IGL884	M	5.38	5.57	5.32	5.86	5.87	5.56	5.63

	65.27

Mean	5.60	5.22

	IGL884	F	5.24	5.44	4.87	5.48	5.05

	S.D.	0.21	0.26

	IGL886	M	5.37	5.12	5.44	5.47	5.23	6.00	5.78	5.26

69.68

Mean	5.46	5.20

	IGL886	F	5.24	5.07	5.41	5.03	5.26

	S.D.	0.30	0.15

	   IGL915 NP

	   IGL915 NP

	IGL867	M	5.52	5.49	5.30	5.41	5.37	5.61	5.25

	87.97

Mean	5.42	5.00

	IGL867	F	4.03	5.33	5.23	5.32	4.82	4.95	5.24	4.98	4.96	5.16

S.D.	0.13	0.38

	IGL898	M	3.86	4.95	5.35	5.38	5.06	5.30	4.99

	77.98

Mean	4.98	4.79

	IGL898	F	4.78	4.43	4.76	4.77	4.74	4.59	4.91	5.00	5.11

	S.D.	0.53	0.20

	IGL929	M	5.15	4.94	4.93	5.31	5.29	3.98	5.77	5.19

74.25

Mean	5.07	4.81

	IGL929	F	5.00	4.96	4.88	4.52	4.97	4.66	4.70

	S.D.	0.51	0.19

	IGL877	M	5.14	4.99	5.19	5.00	4.98	5.07	5.13	5.09

79.87

Mean	5.07	4.91

	IGL877	F	5.18	4.74	5.17	4.73	5.15	4.62	4.99	4.70

S.D.	0.08	0.24

	IGL937	M	5.58	4.74	5.06	4.34	5.21	4.89	4.83

	74.00

Mean	4.95	4.92

	IGL937	F	4.85	4.74	4.90	4.69	5.33	5.10	5.03	4.71

S.D.	0.39	0.22

	IGL950	M	5.32	5.52	5.91	5.41	5.58	5.53

73.98

Mean	5.55	5.09

	IGL950	F	5.00	5.39	4.97	5.18	5.09	5.06	5.17	4.85

S.D.	0.20	0.16

G-8

APPENDIX G - INDIVIDUAL AND MEAN FETAL BODY WEIGHT AND LITTER WEIGHTS

(GRAMS)

TARGET DOSE: 20,000 MG/M3

ANIMAL

	Litter Weights	Fetus Weight

	NUMBER 	SEX

Litter

	Males	Females

	IGL958	M	4.78	5.64	4.99	4.95	5.19

	74.73

Mean	5.11	4.92

	IGL958	F	4.42	4.97	4.88	4.82	4.89	5.25	5.12	5.35	4.82	4.66

S.D.	0.33	0.27

	IGL945	M	4.98	5.45	5.46	5.52

77.07

Mean	5.35	5.06

	IGL945	F	5.28	5.30	4.89	5.31	5.19	5.19	4.88	4.93	4.72	5.19	4.78

	S.D.	0.25	0.22

	IGL967	M	5.50	6.08	5.96	5.18	5.62	5.55	5.47

	81.81

Mean	5.62	5.31

	IGL967	F	5.13	5.36	5.30	5.37	5.13	5.37	5.25	5.54

S.D.	0.31	0.14

	IGL959	M	5.55	6.09	6.09	5.54	5.82	5.30

72.74

Mean	5.73	5.48

	IGL959	F	5.28	5.76	5.72	5.53	5.58	5.16	5.32

	S.D.	0.32	0.23

	IGL962	M	4.45	3.14	5.20	4.82	5.19	5.49	5.06

	62.04

Mean	4.76	4.78

	IGL962	F	4.61	4.54	5.06	4.97	4.45	5.06

S.D.	0.79	0.28

	IGL949	M	5.47	5.39	5.76	5.15

71.89

Mean	5.44	5.01

	IGL949	F	5.08	4.87	5.21	5.16	4.49	4.82	5.08	5.11	5.16	5.14

S.D.	0.25	0.22

	IGL916	M	5.58	5.95	6.25	5.87	5.33

	60.32

Mean	5.80	5.22

	IGL916	F	5.06	5.46	5.15	4.46	5.46	5.75

S.D.	0.35	0.45

	IGL938	M	5.82	5.61	5.57	5.63	5.74

	66.70

Mean	5.67	5.48

	IGL938	F	5.69	5.28	5.43	5.40	5.77	5.62	5.14

	S.D.	0.10	0.23

	IGL961	M	5.43	4.93	5.52	5.22	5.11	4.87	5.06

	75.29

Mean	5.16	4.89

	IGL961	F	4.62	4.80	4.59	5.09	4.79	5.09	4.98	5.19

S.D.	0.24	0.23

	IGL970	M	4.95	5.04	5.34	5.05	5.20	4.94

74.00

Mean	5.09	4.83

	IGL970	F	4.88	4.90	4.83	4.79	4.84	4.77	4.98	4.88	4.61

	S.D.	0.16	0.10

	NOTE: NP- NOT PREGNANT

G-9

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

TOTAL FETUSES WITH EXTERNAL VARIATIONS	0/385

2/302

0/327

0/345

TOTAL LITTERS WITH EXTERNAL VARIATIONS	[0/25]

[2/23]

[0/23]

[0/24]

	TOTAL FETUSES WITH EXTERNAL MALFORMATIONS	1/385

2/302

2/327

0/345

TOTAL LITTERS WITH EXTERNAL MALFORMATIONS	[1/25]

[1/23]

[1/23]

[0/24]

	TOTAL FETUSES WITH VISCERAL VARIATIONS	1/192

0/151

1/162

0/175

TOTAL LITTERS WITH VISCERAL VARIATIONS	[1/25]

[0/23]

[1/23]

[0/24]

	TOTAL FETUSES WITH VISCERAL MALFORMATIONS	0/192

1/151

0/162

1/175

TOTAL LITTERS WITH VISCERAL MALFORMATIONS	[0/25]

[1/23]

[0/23]

[1/24]

	TOTAL FETUSES WITH SKELETAL VARIATIONS	24/193

21/153

15/165

  38/170

TOTAL LITTERS WITH SKELETAL VARIATIONS	[15/25]

[13/23]

[13/23]

[20/24]

	TOTAL FETUSES WITH SKELETAL MALFORMATIONS	2/193

1/153

1/165

1/170

TOTAL LITTERS WITH SKELETAL MALFORMATIONS	[2/25]

[1/23]

[1/23]

[1/24]

	EXTERNAL EXAMINATIONS

	               - TOTAL FETUSES EXAMINED:	385

302

327

345

               - TOTAL LITTERS EXAMINED:	[25]

[23]

[23]

[24]

	INDIVIDUAL EXTERNAL OBSERVATIONS

	               STUNTED  (<4.0 grams)	4

3

3

4

	[2]

[2]

[3]

[4]

	               EDEMA HEAD	0

1

0

0

	[0]

[1]

[0]

[0]

H-1

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL EXTERNAL VARIATIONS

	               PROTRUDING TONGUE	0

2

0

0

	[0]

[2]

[0]

[0]

INDIVIDUAL EXTERNAL MALFORMATIONS

	             MALROTATED HINDPAW	1

2

2

0

	[1]

[1]

[1]

[0]

	             ADACTYLY	0

1

0

0

	[0]

[1]

[0]

[0]

	             CLEFT PALATE	0

1

0

0

	[0]

[1]

[0]

[0]

	             ECTRODACTYLY	0

1

0

0

	[0]

[1]

[0]

[0]

	             HOOKED TAIL	0

1

0

0

	[0]

[1]

[0]

[0]

	             MICROCEPHALY	0

1

0

0

	[0]

[1]

[0]

[0]

	             SHORT TAIL	0

1

0

0

	[0]

[1]

[0]

[0]

H-2

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

VISCERAL EXAMINATIONS

	             - TOTAL FETUSES EXAMINED:	192

151

162

175

             - TOTAL LITTERS EXAMINED:	[25]

[23]

[23]

[24]

	INDIVIDUAL VISCERAL VARIATIONS

	             UMBILICAL ARTERY ARISES FROM LEFT SIDE OF 	1

0

1

0

             URINARY BLADDER	[1]

[0]

[1]

[0]

	INDIVIDUAL VISCERAL MALFORMATIONS

	             MALPOSITIONED KIDNEY	0

1

0

0

	[0]

[1]

[0]

[0]

	             RETINA FOLD	0

0

0

1

	[0]

[0]

[0]

[1]

SKELETAL EXAMINATIONS

	               - TOTAL FETUSES EXAMINED:	193

153

165

170

               - TOTAL LITTERS EXAMINED:	[25]

[23]

[23]

[24]

	INDIVIDUAL OSSIFICATION VARIATIONS

	               STERNEBRAE

	                         ASYMMETRIC	0

2

1

1

	[0]

[2]

[1]

[1]

	                         BIFID	0

1

0

0

	[0]

[1]

[0]

[0]

	                         HYPOPLASTIC	1

1

0

2

	[1]

[1]

[0]

[1]

H-3

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL OSSIFICATION VARIATIONS (CONT'D)

	                STERNEBRAE (CONT'D)

	                          UNOSSIFIED	1

6

4

1

	[1]

[4]

[4]

[1]

	                RIBS

	                         RUDIMENTARY LUMBAR	16

11

8

29

	[12]

[8]

[7]

[16]

	                         SHORT LAST THORACIC	3

1

1

0

	[3]

[1]

[1]

[0]

                 VERTEBRAE

	                         THORACIC CENTRA BIFID	4

0

0

3

	[3]

[0]

[0]

[3]

	                         THORACIC CENTRA DUMBBELL SHAPED	1

0

0

2

	[1]

[0]

[0]

[2]

	                         EXTRA PRESACRAL	0

0

0

1

	[0]

[0]

[0]

[1]

H-4

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL CARTILAGINOUS STRUCTURAL VARIATIONS

	               VERTEBRAE ANLAGE

	                         THORACIC CENTRA DUMBBELL SHAPED	2

1

1

4

	[1]

[1]

[1]

[3]

INDIVIDUAL OSSIFICATION MALFORMATIONS

	               SKULL

	                        MULTIPLE BONES MALFORMED	0

1

0

0

	[0]

[1]

[0]

[0]

              STERNEBRAE

	                        FUSED	1

0

0

0

	[1]

[0]

[0]

[0]

              FOREPAW

	                        MULTIPLE BONES ABSENT	0

1

0

0

	[0]

[1]

[0]

[0]

              RIBS

	                        MULTIPLE BONES MALFORMED	0

1

0

0

	[0]

[1]

[0]

[0]

              VERTEBRAE

	                        LUMBAR ARCH MALFORMED	1

0

0

1

	[1]

[0]

[0]

[1]

	                        SACRAL ARCH MALFORMED	0

0

1

0

	[0]

[0]

[1]

[0]

	                        MULTIPLE VERTEBRAE MALFORMED	0

1

0

0

	[0]

[1]

[0]

[0]

H-5

APPENDIX H  -  FETAL OBSERVATIONS

(INCIDENCE OF FETAL OBSERVATIONS)

	TARGET DOSE:	0 MG/M3

2000 MG/M3

10,000 MG/M3

20,000 MG/M3

INDIVIDUAL OSSIFICATION MALFORMATIONS (CONT'D)

              HINDPAW

	                        MULTIPLE BONES ABSENT	0

1

0

0

	[0]

[1]

[0]

[0]

INDIVIDUAL CARTILAGINOUS MALFORMATIONS

	               RIBS ANLAGE

	                         FUSED	1

0

0

0

	[1]

[0]

[0]

[0]

H-6

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL897

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	F	+

	+

3	A	F	+	+	+

	4	A	M	+

	+

5	A	M	+	+	+

	6	A	M	+

	+

7	A	M	+	+	+

	8	A	F	+

	+

  9C	A	F	+	+	+

	10	A	M	+

	+

11	A	F	+	+	+

	12	A	M	+

	+

13	A	F	+	+	+

	14	A	M	+

	+

15	A	M	+	+	+

	16	A	F	+

	(b)

17	A	M	+	+	+

	18	A	M	+

	(a)

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

(b) - SKELETAL/VERTEBRAE (T11): Bifid centra

H-7

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL899

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	F	+

	+

5	A	F	+	+	+

	6	A	F	+

	+

E

7	A	F	+	+	+

	  8C	A	F	+

	+

9	A	M	+	+	+

	10	A	M	+

	+

11	A	M	+	+	+

	12	A	M	+

	+

13	A	M	+	+	+

	14	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-8

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL874

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	F	+	+	+

	3	A	M	+

	+

4	A	M	+	+	+

	5	A	M	+

	+

6	A	F	+	+	+

	7	A	M	+

	+

8	A	M	+	+	+

	  9C	A	M	+

	+

10	A	M	+	+	+

	11	A	F	+

	+

12	A	F	+	+	+

	13	A	F	+

	+

14	A	M	+	+	+

	15	A	M	+

	+

16	A	M	+	+	+

	17	A	F	+

	(a)

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

- SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-9

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL857

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	4	A	F	+

	+

5	A	F	+	+	+

	6	A	F	+

	+

7	A	F	+	+	+

	8	A	F	+

	+

  9C	A	M	+	+	+

	10	A	F	+

	+

11	A	M	+	+	+

	12	A	M	+

	+

13	A	F	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

	16	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-10

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL865

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	1

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	F	+

	(a)

5	A	F	+	+	+

	6	A	F	+

	+

  7C	A	M	+	+	+

	8	A	F	+

	+

9	A	F	+	+	+

	10	A	F	+

	+

11	A	M	+	+	+

	12	A	M	+

	(b,C)

13	A	F	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

(b) - SKELETAL/RIBS (T13): Short last rib; Right

(C) - SKELETAL/VERTEBRAE (L6): Malformed arch; Left

H-11

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL876

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	  1*	A	M	+

	+

  2*	A	M	+	+	+

	3	A	F	+

	+

  4*	D	F	+	+	+

	5	A	M	+

	+

6	A	F	+	+	+

	7	A	F	+

	+

8	A	M	+	+	+

	9	A	M	+

	+

  10C	A	M	+	+	+

	11	A	F	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	M	+	+	+

	15	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

* - Stunted

H-12

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL880

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	(a)

2	A	F	+	+	+

	3	A	M	+

	+

4	A	M	+	+	+

	5	A	F	+

	+

6	A	M	+	+	+

	7	A	M	+

	+

8	A	M	+	+	+

	9	A	F	+

	+

10	A	M	+	+	+

	  11C	A	F	+

	+

12	A	M	+	+	+

	13	A	M	+

	+

14	A	F	+	+	+

	15	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

- SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-13

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL894

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	F	+	+	+

	3	A	M	+

	+

4	A	M	+	+	+

	5	A	M	+

	+

6	A	M	+	+	+

	7	A	M	+

	+

8	A	F	+	+	+

	  9C	A	F	+

	(a)

10	A	M	+	+	+

	11	A	M	+

	+

12	A	F	+	+	+

	13	A	F	+

	+

14	A	F	+	+	+

	15	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

- SKELETAL/RIBS (T13): Short last rib; Right

H-14

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL902

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	(a)

2	A	M	+	+	+

	3	A	M	+

	+

4	A	F	+	+	+

	E

  EC

5	A	F	+

	+

6	A	F	+	+	+

	7	A	F	+

	+

8	A	M	+	+	+

	9	A	M	+

	+

10	A	M	+	+	+

	11	A	F	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	F	+	+	+

	15	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

H-15

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL891

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	E

4	A	F	+

	+

  5C	A	M	+	+	+

	6	A	F	+

	+

7	A	M	+	+	+

	8	A	M	+

	(b)

9	A	M	+	+	+

	10	A	F	+

	(a)

11	A	M	+	+	+

	12	A	M	+

	+

13	A	M	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

	16	A	M	+

	+

17	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (II): Hypoplastic

(b) - SKELETAL/RIBS (L1): Rudimentary; Left

H-16

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL901

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	F	+

	+

3	A	F	+	+	+

	4	A	M	+

	+

5	A	M	+	+	+

	6	A	F	+

	+

7	A	M	+	+	+

	  8C	A	F	+

	+

9	A	F	+	+	+

	10	A	F	+

	+

E

11	A	F	+	+	+

	12	A	F	+

	+

13	A	M	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

	16	A	F	+

	+

17	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-17

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL904

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	M	+	+	+

	3	A	M	+

	+

4	A	M	+	+	+

	5	A	M	+

	+

6	A	F	+	+	+

	7	A	M	+

	+

8	A	M	+	+	+

	  9C	A	F	+

	+

10	A	F	+	+	+

	11	A	F	+

	+

12	A	F	+	+	+

	13	A	F	+

	+

14	A	M	+	+	+

	15	A	M	+

	+

16	A	M	+	+	+

	17	A	F	+

	+

18	A	M	+	+	+

	19	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-18

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL910

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	M	+	+	+

	3	A	F	+

	+

4	A	M	+	+	+

	5	A	M	+

	+

6	A	M	+	+	+

	7	A	F	+

	+

8	A	M	+	+	+

	  9C	A	M	+

	+

10	A	M	+	+	+

	11	A	F	+

	+

12	A	F	+	+	+

	13	A	F	+

	+

14	A	F	+	+	+

	15	A	F	+

	(a)

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:  Fetus numbers 7, 9, 11, and 13 found with identification tags detached, numbers arbitrarily assigned for skeletal exams.

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

H-19

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL933

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	(a)

3	A	M	+	+	+

	4	A	F	+

	+

5	A	M	+	+	+

	6	A	M	+

	+

7	A	F	+	+	+

	8	A	M	+

	+

  9C	A	M	+	+	+

	10	A	M	+

	+

11	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (V): Unossified

H-20

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL956

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	F	+	+	+

	3	A	M	+

	(a)

4	A	F	+	+	+

	5	A	M	+

	+

  6C	A	M	+	+	+

	7	A	M	+

	+

8	A	F	+	+	+

	9	A	M	+

	+

10	A	M	+	+	+

	11	A	F	+

	+

12	A	M	+	+	+

	13	A	F	+

	+

14	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

H-21

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL920

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	F	+	+	+

	3	A	F	+

	+

4	A	F	+	+	+

	5	A	F	+

	+

6	A	M	+	+	+

	7	A	F	+

	+

8	A	M	+	+	+

	9	A	M	+

	+

10	A	F	+	+	+

	  11C	A	F	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	F	+	+	+

	15	A	M	+

	+

16	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-22

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL931

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	M	+

	(a,c)

3	A	M	+	+	+

	4	A	F	+

	+

5	A	M	+	+	+

	  6C	A	F	+

	+

7	A	M	+	+	+

	8	A	M	+

	+

9	A	M	+	+	+

	10	A	M	+

	(b,d)

11	A	F	+	+	+

	12	A	M	+

	+

13	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T11): Bifid centra

(b) - SKELETAL/VERTEBRAE (T12): Bifid centra

(c) - SKELETAL/VERTEBRAE (T11 anlage): Dumbbell shaped centra

(d) - SKELETAL/VERTEBRAE (T12 anlage): Dumbbell shaped centra

H-23

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL953

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	5           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	(a)

3	A	M	+	+	+

	4	A	F	+

	+

5	A	M	+	+	+

	6	A	F	+

	+

7	A	F	+	+	+

	8	A	M	+

	(b)

9	A	M	+	+	+

	10	A	F	+

	(a)

  11C	A	F	+	+	+

	12	A	M	+

	+

13	A	M	+	+	+

	14	A	M	+

	+

15	A	M	+	+	+

	16	A	M	+

	(a)

17	A	F	+	+	+

	18	A	M	+

	(a)

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

(b) - SKELETAL/RIBS (L1): Rudimentary; Left

H-24

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL869

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	M	+

	+

5	A	M	+	+	+

	6	A	F	+

	+

7	A	M	+	+	+

	8	A	M	+

	+

  9C	A	F	+	+	+

	10	A	M	+

	+

11	A	F	+	+	+

	12	A	M	+

	+

13	A	M	+	+	+

	14	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-25

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL921

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	4	A	F	+

	+

5	A	F	+	+	+

	6	A	F	+

	+

  7C	A	M	+	+	+

	8	A	F	+

	+

9	A	M	+	+	+

	10	A	M	+

	+

11	A	M	+	+	+

	12	A	F	+

	+

13	A	F	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-26

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL928

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	1           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	F	+	+	+

	3	A	M	+

	+

4	A	M	+	+	(a)

	5	A	F	+

	+

6	A	M	+	+	+

	7	A	F	+

	+

8	A	M	+	+	+

	9	A	F	+

	+

10	A	M	+	+	+

	  11C	A	M	+

	+

12	A	M	+	+	+

	13	A	F	+

	(b)

14	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - ABDOMEN/THORAX:  Umbilical artery arises from left side of urinary bladder

(b) - SKELETAL/RIBS (L1): Rudimentary; Right

H-27

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL952

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	M	+	+	+

	E

3	A	F	+

	+

4	A	M	+	+	+

	5	A	F	+

	+

6	A	F	+	+	+

	E

7	A	F	+

	+

  8C	A	M	+	+	+

	9	A	M	+

	+

10	A	M	+	+	+

	11	A	F	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-28

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL957

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	4	A	F	+

	+

5	A	F	+	+	+

	6	A	F	+

	+

  7C	A	F	+	+	+

	8	A	F	+

	+

9	A	F	+	+	+

	10	A	M	+

	+

11	A	M	+	+	+

	12	A	F	+

	+

13	A	F	+	+	+

	14	A	F	+

	(a)

15	A	M	+	+	+

	16	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Right

H-29

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL988

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	1

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	1

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	M	+	+	+

	3	A	M	+

	+

4	A	M	+	+	+

	  5*	A	M	+

	(B,C,d,f,g,h)

6	A	F	+	+	+

	7	A	F	+

	(e)

8	A	F	+	+	+

	9C	A	M	+

	+

10	A	F	(A)	+	+

	11	A	M	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	M	+	+	+

	15	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

 *   	- Stunted

(A) - EXTERNAL: Malrotated hindpaw; Right

(B) - SKELETAL/STERNEBRAE (IV-VI): Fused

(C) - SKELETAL/RIBS (T1-2 anlage): Fused; Right

(d) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

(e) - SKELETAL/RIBS (T13): Short last rib; Right

(f) - SKELETAL/VERTEBRAE (T1): Bifid centra

(g) - SKELETAL/VERTEBRAE (T2): Dumbbell shaped centra

(h) - SKELETAL/VERTEBRAE (T9): Dumbbell shaped centra

H-30

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 0 MG/M3

ANIMAL NUMBER:  IGL969

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	F	+	+	+

	4	A	M	+

	+

5	A	M	+	+	+

	  6C	A	F	+

	+

7	A	F	+	+	+

	8	A	M	+

	+

9	A	M	+	+	+

	10	A	F	+

	+

11	A	M	+	+	+

	12	A	F	+

	+

13	A	M	+	+	+

	14	A	M	+

	+

15	A	F	+	+	+

	16	A	F	+

	+

17	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-31

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL889

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	M	+

	+

5	A	F	+	+	+

	6	A	F	+

	+

7	A	F	+	+	+

	  8C	A	M	+

	(a)

9	A	F	+	+	+

	10	A	M	+

	+

11	A	M	+	+	+

	12	A	M	+

	+

13	A	M	+	+	+

	14	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T11 anlage): Dumbbell shaped centra

H-32

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL893

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	4	A	F	+

	+

  5C	A	F	+	+	+

	6	A	M	+

	(a)

7	A	F	+	+	+

	8	A	M	+

	+

9	A	F	+	+	+

	10	A	M	+

	+

11	A	M	+	+	+

	12	A	F	+

	+

13	A	M	+	+	+

	14	A	M	+

	+

15	A	F	+	+	+

	16	A	F	+

	(b)

17	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (II-IV): Asymmetric

(b) - SKELETAL/RIBS (L1): Rudimentary; Right

H-33

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL885

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	4	A	M	+

	+

5	A	F	+	+	+

	  6C	A	F	+

	+

7	A	F	+	+	+

	8	A	F	+

	+

9	A	F	+	+	+

	10	A	M	+

	+

11	A	F	+	+	+

	12	A	F	+

	+

13	A	M	+	+	+

	14	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-34

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL890

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	F	+	+	+

	3	A	M	+

	+

4	A	F	+	+	+

	5	A	M	+

	+

6	A	M	+	+	+

	7	A	F	+

	+

  8C	A	M	+	+	+

	9	A	M	+

	+

10	A	F	+	+	+

	11	A	F	+

	+

12	A	M	+	+	+

	13	A	F	+

	+

14	A	F	+	+	+

	15	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-35

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL863

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	3           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	F	+	+	+

	4	A	F	+

	+

5	A	M	+	+	+

	6	A	M	+

	(a)

7	A	F	+	+	+

	8	A	F	+

	+

  9C	A	F	+	+	+

	10	A	F	+

	(a)

11	A	M	+	+	+

	12	A	F	+

	(a)

13	A	F	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

	16	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (V) - Unossified

H-36

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL878

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	3           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	F	+	+	+

	3	A	M	+

	(c)

4	A	M	+	+	+

	5	A	M	+

	+

6	A	F	+	+	+

	7	A	M	+

	(c)

8	A	F	+	+	+

	9	A	M	+

	+

10	A	M	+	+	+

	11	A	M	+

	(a,b)

  12C	A	F	+	+	+

	13	A	M	+

	+

14	A	M	+	+	+

	15	A	M	+

	+

16	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (I, II): Bifid

(b) - SKELETAL/STERNEBRAE (III, IV): Asymmetric

(c) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-37

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL882

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	F	+	+	+

	3	A	F	+

	+

4	A	F	+	+	+

	5	A	M	+

	+

6	A	F	+	+	+

	7	A	M	+

	+

8	A	M	+	+	+

	  9C	A	M	+

	+

10	A	F	+	+	+

	11	A	M	+

	+

12	A	F	+	+	+

	13	A	F	+

	+

14	A	F	+	+	+

	15	A	F	+

	+

16	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-38

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL911

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	1           MALFORMATIONS:  	2

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	3           MALFORMATIONS:   	1

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

  3*	A	F	(A,B,c,D,E,F,H,I)

(J)	(K,L,m,n,O,Q,R)

4	A	M	(G)

	+

5	A	F	+	+	+

	6	A	F	+

	+

7	A	M	+	+	+

	  8C	A	M	+

	(p)

9	A	M	+	+	+

	10	A	F	+

	+

E

11	A	M	+	+	+

	12	A	F	+

	+

13	A	F	+	+	+

	14	A	F	+

	(p)

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

  *	- Stunted					      (n) - SKELETAL/STERNEBRAE (IV,V):Unossified

(A)	- EXTERNAL: Cleft palate			      (O) - SKELETAL/RIBS: Multiple bones malformed

(B)	- EXTERNAL: Microcephaly	(p) - SKELETAL/RIBS (L1): Rudimentary; Left

(c)	- EXTERNAL: Protruding tongue		      (Q) - SKELETAL/VERTEBRAE: Multiple bones

(D)	- EXTERNAL: Adactyly forepaw; Bilateral		  malformed

(E)	- EXTERNAL: Ectrodactyly hindpaw; Bilateral  (R) - SKELETAL/HINDPAW: Multiple bones absent

	(2 digits on each paw)

(F)	- EXTERNAL: Malrotated hindpaw; Left

(G) - EXTERNAL: Malrotated hindpaw; Right

(H)	- EXTERNAL: Short tail

(I)	- EXTERNAL: Hooked tail

(J)	- ABDOMEN/THORAX:  Malpositioned kidney; Bilateral

(K) - SKELETAL/SKULL: Multiple bones malformed

(L) - SKELETAL/FOREPAW: Multiple bones absent

(m) - SKELETAL/STERNEBRAE (III): Hypoplastic

H-39

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL868

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	F	+	+	+

	3	A	F	+

	+

4	A	M	+	+	+

	5	A	F	+

	+

6	A	F	+	+	+

	7	A	F	+

	+

  8C	A	M	+	+	+

	9	A	F	+

	+

10	A	M	+	+	+

	11	A	F	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-40

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL912

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	(a)

2	A	M	+	+	+

	3	A	M	+

	+

4	A	F	+	+	+

	5	A	F	+

	+

  6C	A	F	+	+	+

	7	A	M	+

	+

8	A	M	+	+	+

	9	A	M	+

	+

10	A	M	+	+	+

	11	A	F	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	F	+	+	+

	15	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

H-41

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL913

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	F	+	+	+

	4	A	M	+

	+

5	A	F	+	+	+

	6	A	F	+

	+

  7C	A	M	+	+	+

	8	A	M	+

	+

9	A	F	+	+	+

	10	A	M	+

	+

11	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-42

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL925

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	M	+

	+

  5C	A	M	+	+	+

	6	A	M	+

	+

7	A	F	+	+	+

	8	A	F	+

	+

9	A	F	+	+	+

	10	A	M	+

	+

11	A	M	+	+	+

	12	A	F	+

	+

13	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-43

 APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL871

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	4	A	M	+

	(a)

5	A	M	+	+	+

	  6C	A	M	+

	+

7	A	F	+	+	+

	8	A	M	+

	+

9	A	M	+	+	+

	10	A	M	+

	+

11	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (V): Unossified

H-44

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL922

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	M	+	+	+

	3	A	F	+

	+

4	A	F	+	+	+

	5	A	F	+

	+

6	A	F	+	+	+

	7	A	F	+

	+

8	A	M	+	+	+

	  9C	A	M	+

	+

10	A	M	+	+	+

	11	A	M	+

	+

12	A	M	+	+	+

	13	A	F	+

	+

14	A	F	+	+	+

	15	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-45

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL951

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	F	+

	+

3	A	F	+	+	+

	4	A	F	+

	+

5	A	M	+	+	+

	6	A	M	+

	+

7	A	M	+	+	+

	  8C	A	F	+

	+

9	A	M	+	+	+

	10	A	M	+

	+

11	A	M	+	+	+

	12	A	F	+

	+

13	A	F	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-46

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL859

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	E

4	A	F	+

	+

5	A	M	+	+	+

	  6C	A	F	+

	+

7	A	M	+	+	+

	8	A	M	+

	+

9	A	F	+	+	+

	10	A	M	+

	+

11	A	F	+	+	+

	E

12	A	F	+

	(a)

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE: Fetus numbers 8, 10 and 12 found with identification tags incorrectly numbered, numbers arbitrarily assigned for skeletal exams.

(a) - SKELETAL/RIBS (L1): Rudimentary; Right

H-48

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL943

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	F	+	+	+

	4	A	F	+

	+

5	A	M	+	+	+

	6	A	F	+

	+

  7C	A	F	+	+	+

	8	A	M	+

	+

9	A	F	+	+	+

	10	A	M	+

	+

11	A	M	+	+	+

	12	A	M	+

	(a)

13	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

H-48

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL948

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	F	+	+	+

	3	A	F	+

	+

4	A	M	+	+	+

	5	A	F	+

	+

6	A	F	+	+	+

	7	A	M	+

	+

  8C	A	M	+	+	+

	E

9	A	F	+

	(a)

10	A	M	+	+	+

	11	A	M	+

	(a)

12	A	F	+	+	+

	13	A	M	+

	+

14	A	M	+	+	+

	15	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Right

H-49

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL974

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	1           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1C	A	F	(*,a)

+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

  *  - Edema head

(a)	- EXTERNAL:  Protruding tongue

H-50

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL888

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	F	+	+	+

	3	A	M	+

	+

4	A	F	+	+	+

	5	A	M	+

	+

6	A	F	+	+	+

	7	A	F	+

	+

8	A	F	+	+	+

	9	A	F	+

	+

10	A	M	+	+	+

	11	A	F	+

	+

  12C	A	F	+	+	+

	13	A	F	+

	+

14	A	M	+	+	+

	15	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-51

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL976

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	F	+	+	+

	  3C	A	M	+

	(a)

4	A	M	+	+	+

	5	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (T13): Short last rib; Left

H-52

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL923

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	M	+

	+

3	A	M	+	+	+

	4	A	F	+

	+

  5C	A	F	+	+	+

	6	A	F	+

	+

7	A	F	+	+	+

	8	A	F	+

	+

9	A	F	+	+	+

	  10*	A	M	+

	(a)

  11*	A	F	+	+	+

	12	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

  *	- Stunted

(a) -  SKELETAL/STERNEBRAE (V): Unossified

H-53

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 2000 MG/M3

ANIMAL NUMBER:  IGL924

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SFX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	F	+	+	+

	  3C	A	M	+

	+

4	A	F	+	+	+

	5	A	F	+

	+

6	A	F	+	+	+

	7	A	M	+

	+

8	A	F	+	+	+

	9	A	F	+

	+

10	A	F	+	+	+

	11	A	F	+

	+

12	A	M	+	+	+

	13	A	F	+

	(a)

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-54

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL870

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	M	+	+	+

	3	A	F	+

	+

4	A	F	+	+	+

	5	A	M	+

	+

6	A	M	+	+	+

	  7C	A	F	+

	+

8	A	M	+	+	+

	9	A	F	+

	+

10	A	M	+	+	+

	11	A	M	+

	+

E

12	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-55

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL875

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	M	+

	+

3	A	M	+	+	+

	4	A	M	+

	+

5	A	M	+	+	+

	6	A	M	+

	+

  7C	A	M	+	+	+

	8	A	M	+

	+

9	A	F	+	+	+

	10	A	F	+

	+

11	A	F	+	+	+

	12	A	M	+

	+

13	A	M	+	+	+

	14	A	M	+

	+

15	A	F	+	+	+

	16	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:  Fetus numbers 10 and 14 found with identification tags detached, numbers arbitrarily assigned for skeletal exams.

H-56

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL862

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	F	+	+	+

	3	A	F	+

	+

4	A	M	+	+	+

	5	A	F	+

	+

6	A	M	+	+	+

	  7C	A	M	+

	+

8	A	F	+	+	+

	9	A	F	+

	+

10	A	F	+	+	+

	11	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-57

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL858

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	F	+	+	+

	3	A	M	+

	+

4	A	F	+	+	+

	5	A	F	+

	+

6	A	M	+	+	+

	7	A	F	+

	+

8	A	M	+	+	+

	9	A	F	+

	+

  10C	A	F	+	+	+

	E

11	A	M	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	F	+	+	+

	15	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-58

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL883

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	2

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	4	A	F	(A)

	+

5	A	F	+	+	+

	6	A	F	+

	+

7	A	M	(A)	+	+

	8	A	M	+

	+

9	A	F	+	+	+

	  10C	A	M	+

	+

11	A	F	+	+	+

	12	A	F	+

	+

13	A	F	+	+	+

	E

14	A	F	+

	+

15	A	M	+	+	+

	16	A	F	+

	(b)

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(A) - EXTERNAL:  Malrotated hindpaw; Left

(b)  - SKELETAL/STERNEBRAE (V): Unossified

H-59

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL896

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	1

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	(a)

2	A	M	+	+	+

	E

3	A	M	+

	+

4	A	F	+	+	+

	5	A	F	+

	+

6	A	M	+	+	+

	7	A	M	+

	+

8	A	M	+	+	+

	  9C	A	M	+

	(a, B)

10	A	M	+	+	+

	11	A	M	+

	+

12	A	M	+	+	+

	13	A	F	+

	+

14	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

(B) - SKELETAL/VERTEBRAE (S1): Malformed arch; Left

H-60

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL906

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	M	+	+	+

	3	A	M	+

	+

4	A	F	+	+	+

	5	A	F	+

	+

   6C	A	F	+	+	+

	7	A	M	+

	(a)

8	A	F	+	+	+

	E

9	A	M	+

	+

10	A	F	+	+	+

	11	A	M	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

H-61

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL861

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	4	A	M	+

	+

5	A	F	+	+	+

	6	A	F	+

	+

7	A	F	+	+	+

	8	A	M	+

	+

   9C	A	F	+	+	+

	10	A	F	+

	+

11	A	F	+	+	+

	12	A	F	+

	+

13	A	M	+	+	+

	  14*	A	M	+

	(a)

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

  * - Stunted

(a) - SKELETAL/STERNEBRAE (VI) – Unossified

H-62

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL903

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	1           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	M	+

	+

5	A	M	+	+	+

	6	A	M	+

	+

7	A	F	+	+	+

	8	A	F	+

	+

   9C	A	F	+	+	(a)

	10	A	F	+

	(b)

11	A	M	+	+	+

	12	A	M	+

	+

13	A	F	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

	16	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a)	- ABDOMEN/THORAX:  Umbilical artery arises from left side of urinary bladder

(b) - SKELETAL/STERNEBRAE (V) – Unossified

H-63

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL914

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	F	+	+	+

	3	A	M	+

	+

4	A	F	+	+	+

	5	A	F	+

	+

6	A	M	+	+	+

	7	A	M	+

	+

8	A	F	+	+	+

	9	A	M	+

	(a)

   EC

10	A	M	+	+	+

	11	A	F	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/STERNEBRAE (II,IV) - Asymmetric

H-64

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL918

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	M	+	+	+

	3	A	M	+

	+

4	A	F	+	+	+

	   5C	A	M	+

	+

6	A	M	+	+	+

	7	A	M	+

	(a)

8	A	M	+	+	+

	9	A	M	+

	+

10	A	F	+	+	+

	11	A	F	+

	+

12	A	M	+	+	+

	13	A	F	+

	+

14	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-65

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL907

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	F	+

	+

3	A	F	+	+	+

	4	A	F	+

	(a)

5	A	M	+	+	+

	6	A	F	+

	+

7	A	F	+	+	+

	8	A	M	+

	+

   9C	A	F	+	+	+

	10	A	F	+

	+

11	A	F	+	+	+

	12	A	F	+

	+

13	A	M	+	+	+

	14	A	M	+

	+

15	A	F	+	+	+

	16	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

H-66

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL909

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	F	+	+	+

	4	A	F	+

	+

5	A	F	+	+	+

	6	A	F	+

	+

7	A	M	+	+	+

	8	A	M	+

	+

   9C	A	M	+	+	+

	10	A	M	+

	+

11	A	F	+	+	+

	12	A	M	+

	+

13	A	F	+	+	+

	14	A	F	+

	+

15	A	M	+	+	+

	16	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-67

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL946

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	M	+	+	+

	3	A	F	+

	+

  4C	A	M	+	+	+

	5	A	M	+

	+

6	A	F	+	+	+

	7	A	F	+

	+

8	A	M	+	+	+

	9	A	M	+

	+

10	A	M	+	+	+

	11	A	M	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	F	+	+	+

	15	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-68

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL954

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	M	+	+	+

	3	A	F	+

	(b)

4	A	F	+	+	+

	5	A	F	+

	(a)

  6*	A	F	+	+	+

	  7C	A	F	+

	+

8	A	F	+	+	+

	9	A	M	+

	+

10	A	F	+	+	+

	11	A	M	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	M	+	+	+

	15	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

 *  - Stunted

(a) - SKELETAL/STERNEBRAE (V): Unossified

(b) - SKELETAL/RIBS (L1): Rudimentary; Left

H-69

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL955

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	F	+

	+

5	A	M	+	+	+

	   6C	A	M	+

	+

7	A	F	+	+	+

	8	A	M	+

	+

9	A	F	+	+	+

	10	A	F	+

	+

11	A	F	+	+	+

	12	A	M	+

	(a)

13	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T11 anlage): Dumbbell shaped centra

H-70

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL934

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	M	+	+	+

	3	A	M	+

	+

4	A	M	+	+	+

	5	A	M	+

	+

6	A	F	+	+	+

	7	A	M	+

	+

8	A	M	+	+	+

	   9C	A	F	+

	+

10	A	M	+	+	+

	11	A	M	+

	+

12	A	M	+	+	+

	13	A	F	+

	+

14	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-71

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL881

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	M	+

	+

5	A	F	+	+	+

	   6C	A	M	+

	+

7	A	F	+	+	+

	8	A	F	+

	+

9	A	F	+	+	+

	E

10	A	F	+

	+

11	A	F	+	+	+

	12	A	F	+

	+

13	A	F	+	+	+

	14	A	M	+

	(a)

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (T13): Short last rib; Right

H-72

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL917

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	M	+

	+

3	A	M	+	+	+

	4	A	F	+

	+

5	A	M	+	+	+

	6	A	F	+

	+

7	A	M	+	+	+

	   8C	A	F	+

	+

9	A	M	+	+	+

	10	A	F	+

	+

11	A	M	+	+	+

	12	A	F	+

	+

13	A	F	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

	16	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-73

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL940

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	(a)

2	A	M	+	+	+

	E

3	A	M	+

	+

  4C	A	F	+	+	+

	5	A	F	+

	+

6	A	M	+	+	+

	7	A	M	+

	+

E

8	A	M	+	+	+

	9	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Right

H-74

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL963

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	  4C	A	M	+

	+

5	A	M	+	+	+

	6	A	M	+

	+

7	A	M	+	+	+

	8	A	F	+

	+

9	A	M	+	+	+

	10	A	F	+

	+

11	A	M	+	+	+

	12	A	F	+

	(a)

13	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Right

H-75

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL972

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	F	+	+	+

	3	A	M	+

	+

4	A	M	+	+	+

	  5C	A	F	+

	+

6	A	M	+	+	+

	7	A	F	+

	+

8	A	F	+	+	+

	9	A	M	+

	+

10	A	F	+	+	+

	11	A	M	+

	+

12	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-76

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 10,000 MG/M3

ANIMAL NUMBER:  IGL895

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	4	A	F	+

	+

5	A	F	+	+	+

	6	A	M	+

	+

7	A	M	+	+	+

	8	A	M	+

	+

   9C	A	M	+	+	+

	10	A	F	+

	+

11	A	M	+	+	+

	12	A	M	+

	+

13	A	F	+	+	+

	14	A	M	+

	+

15	A	F	+	+	+

	16	A	M	+

	+

  17*	A	M	+	+	+

	18	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

*	-  Stunted

H-77

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL866

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	1

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	M	+	+	+

	3	A	F	+

	+

4	A	F	+	+	+

	   5C	A	M	+

	+

6	A	M	+	(A)	+

	7	A	F	+

	(b)

8	A	F	+	+	+

	9	A	M	+

	+

10	A	F	+	+	+

	11	A	M	+

	+

12	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(A) - VISCERAL/HEAD:  Retinal fold; Left

(b)  - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-78

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL892

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	M	+	+	+

	3	A	M	+

	+

4	A	M	+	+	+

	   5C	A	F	+

	+

6	A	F	+	+	+

	7	A	F	+

	(a)

8	A	F	+	+	+

	9	A	M	+

	+

10	A	M	+	+	+

	11	A	M	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	M	+	+	+

	15	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Right

H-79

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL864

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	M	+	+	+

	3	A	M	+

	+

4	A	M	+	+	+

	5	A	F	+

	+

6	A	M	+	+	+

	7	A	M	+

	+

   8C	A	F	+	+	+

	9	A	M	+

	+

10	A	M	+	+	+

	11	A	F	+

	(a)

12	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-80

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL872

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	M	+	+	+

	3	A	F	+

	+

4	A	F	+	+	+

	5	A	F	+

	+

6	A	F	+	+	+

	7	A	F	+

	+

8	A	F	+	+	+

	   9C	A	F	+

	(a)

10	A	F	+	+	+

	11	A	F	+

	+

12	A	M	+	+	+

	13	A	M	+

	+

14	A	M	+	+	+

	  15*	A	M	+

	(a)

16	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

 *  - Stunted

(a) - SKELETAL/STERNEBRAE (VI): Hypoplastic

H-81

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL873

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	4	A	M	+

	+

5	A	F	+	+	+

	6	A	F	+

	+

7	A	M	+	+	+

	   8C	A	M	+

	+

9	A	F	+	+	+

	10	A	F	+

	+

11	A	F	+	+	+

	12	A	F	+

	(a,b)

13	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T12): Bifid centra

(b) - SKELETAL/VERTEBRAE (T12 anlage): Dumbbell shaped centra

H-82

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL879

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	M	+

	(a)

5	A	F	+	+	+

	6	A	F	+

	+

7	A	F	+	+	+

	8	A	F	+

	+

9	A	F	+	+	+

	   10C	A	M	+

	(b,c)

11	A	M	+	+	+

	12	A	F	+

	+

13	A	M	+	+	+

	14	A	F	+

	+

15	A	M	+	+	+

	16	A	M	+

	+

17	A	F	+	+	+

	18	A	F	+

	+

19	A	F	+	+	+

	20	A	M	+

	+

21	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T9): Dumbbell shaped centra

(b) - SKELETAL/VERTEBRAE (T12): Bifid centra

(c) - SKELETAL/VERTEBRAE (T12 anlage): Dumbbell shaped centra

H-83

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL884

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	(a)

2	A	F	+	+	+

	3	A	F	+

	+

4	A	M	+	+	+

	5	A	M	+

	+

6	A	M	+	+	+

	7	A	F	+

	+

   8C	A	M	+	+	+

	9	A	M	+

	(b)

10	A	M	+	+	+

	11	A	F	+

	+

12	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

(b) - SKELETAL/RIBS (L1): Rudimentary; Left

H-84

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL886

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	3           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	(a)

2	A	M	+	+	+

	3	A	M	+

	+

4	A	M	+	+	+

	5	A	F	+

	+

6	A	F	+	+	+

	7	A	M	+

	+

   8C	A	M	+	+	+

	9	A	M	+

	+

10	A	F	+	+	+

	11	A	F	+

	(b)

E

12	A	M	+	+	+

	13	A	F	+

	(a)

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

(b) - SKELETAL/RIBS (L1): Rudimentary; Left

H-85

 APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL867

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	F	+

	+

5	A	M	+	+	+

	E

   6C	A	M	+

	+

7	A	F	+	+	+

	8	A	F	+

	+

9	A	F	+	+	+

	10	A	M	+

	+

11	A	M	+	+	+

	12	A	F	+

	(a)

13	A	M	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

	16	A	F	+

	+

17	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

H-86

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL898

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	  1*	A	M	+

	+

2	A	F	+	+	+

	3	A	F	+

	+

4	A	M	+	+	+

	5	A	F	+

	+

6	A	M	+	+	+

	7	A	M	+

	+

8	A	M	+	+	+

	9	A	F	+

	+

10	A	F	+	+	+

	11	A	F	+

	+

  12C	A	F	+	+	+

	13	A	F	+

	+

14	A	F	+	+	+

	15	A	M	+

	+

16	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

*	- Stunted

H-87

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL929

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	M	+

	+

3	A	M	+	+	+

	4	A	F	+

	+

5	A	F	+	+	+

	6	A	M	+

	+

7	A	F	+	+	+

	8	A	M	+

	+

  9*	A	M	+	+	+

	   10C	A	M	+

	(a)

11	A	F	+	+	+

	12	A	F	+

	+

13	A	M	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

 *  - Stunted

(a) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-88

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL877

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	F	+

	+

3	A	F	+	+	+

	4	A	M	+

	+

5	A	M	+	+	+

	   6C	A	F	+

	+

7	A	M	+	+	+

	8	A	F	+

	+

9	A	M	+	+	+

	10	A	M	+

	+

11	A	F	+	+	+

	12	A	M	+

	(a)

13	A	F	+	+	+

	14	A	M	+

	+

15	A	F	+	+	+

	16	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

H-89

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL937

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	F	+

	(a)

5	A	M	+	+	+

	6	A	M	+

	+

  7C	A	F	+	+	+

	8	A	F	+

	+

9	A	M	+	+	+

	10	A	M	+

	+

11	A	M	+	+	+

	12	A	F	+

	+

13	A	M	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

H-90

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL950

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	3           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	M	+	+	+

	3	A	F	+

	+

4	A	F	+	+	+

	   5C	A	M	+

	+

6	A	F	+	+	+

	7	A	F	+

	+

8	A	F	+	+	+

	9	A	M	+

	(a)

10	A	M	+	+	+

	11	A	F	+

	(a)

12	A	F	+	+	+

	13	A	M	+

	(b)

14	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

(b) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-91

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL958

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

2	A	F	+	+	+

	3	A	F	+

	+

4	A	F	+	+	+

	5	A	F	+

	+

6	A	F	+	+	+

	7	A	M	+

	+

8	A	M	+	+	+

	   9C	A	F	+

	+

10	A	F	+	+	+

	11	A	F	+

	+

12	A	F	+	+	+

	13	A	M	+

	+

14	A	F	+	+	+

	15	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-92

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL945

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	F	+

	(a)

3	A	F	+	+	+

	4	A	M	+

	+

5	A	F	+	+	+

	   6C	A	F	+

	+

7	A	M	+	+	+

	8	A	F	+

	+

9	A	F	+	+	+

	10	A	M	+

	+

11	A	F	+	+	+

	12	A	F	+

	+

13	A	F	+	+	+

	14	A	F	+

	+

15	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/VERTEBRAE (T11): Bifid centra

H-93

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL967

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	F	+

	+

5	A	F	+	+	+

	6	A	F	+

	+

   7C	A	M	+	+	+

	8	A	M	+

	+

9	A	M	+	+	+

	10	A	F	+

	+

11	A	F	+	+	+

	12	A	M	+

	+

13	A	F	+	+	+

	     E

14	A	M	+

	+

15	A	F	+	+	+

	     E

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-94

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL959

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	3           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	M	+

	(a)

3	A	F	+	+	+

	4	A	F	+

	+

5	A	M	+	+	+

	   6C	A	M	+

	+

7	A	F	+	+	+

	8	A	F	+

	+

E

9	A	F	+	+	+

	10	A	M	+

	(b)

11	A	M	+	+	+

	12	A	M	+

	(c)

13	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Left

(b) - SKELETAL/RIBS (L1): Rudimentary; Right

(c) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

H-95

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL962

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	4           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	M	+

	+

  2*	A	M	+	+	+

	3	A	M	+

	(a,b,d)

4	A	M	+	+	+

	5	A	F	+

	(e)

6	A	F	+	+	+

	7	A	F	+

	(f)

8	A	F	+	+	+

	E

9	A	M	+

	+

  10C	A	F	+	+	+

	11	A	M	+

	(c)

12	A	F	+	+	+

	13	A	M	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

*	- Stunted

(a) - SKELETAL/STERNEBRAE (II-IV): Asymmetric

(b) - SKELETAL/STERNEBRAE (VI): Unossified

(c) - SKELETAL/RIBS (L1): Rudimentary; Left

(d) - SKELETAL/VERTEBRAE (T11-13 anlage): Dumbbell shaped centra

(e) - SKELETAL/VERTEBRAE (T9): Dumbbell shaped centra

(f) - SKELETAL/VERTEBRAE (T10 anlage): Dumbbell shaped centra

H-96

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL949

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	4           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	(a)

3	A	M	+	+	+

	4	A	F	+

	(b)

5	A	F	+	+	+

	6	A	F	+

	(a)

7	A	F	+	+	+

	   8C	A	M	+

	+

9	A	M	+	+	+

	10	A	M	+

	(b)

11	A	F	+	+	+

	12	A	F	+

	+

13	A	F	+	+	+

	14	A	F	+

	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Right

(b) - SKELETAL/RIBS (L1): Rudimentary; Left

H-97

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL916

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	1           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	M	+

	+

3	A	F	+	+	+

	4	A	F	+

	+

5	A	M	+	+	+

	   EC

6	A	M	+

	(a)

7	A	M	+	+	+

	8	A	F	+

	+

9	A	F	+	+	+

	10	A	F	+

	+

11	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Right

H-98

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL938

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	3           MALFORMATIONS:   	1

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	F	+	+	+

	3	A	F	+

	(a,b,C)

E

  4C	A	M	+	+	+

	5	A	F	+

	(a)

6	A	M	+	+	+

	7	A	M	+

	+

8	A	F	+	+	+

	9	A	M	+

	(a)

10	A	F	+	+	+

	11	A	M	+

	+

12	A	F	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

(b) - SKELETAL/VERTEBRAE (L): Presacral vertebrae

(C) - SKELETAL/VERTEBRAE (L7): Malformed arch; Left

H-99

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL961

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	0           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+	+	+

	2	A	F	+

	+

3	A	M	+	+	+

	4	A	F	+

	+

  5C	A	F	+	+	+

	6	A	M	+

	+

7	A	F	+	+	+

	8	A	M	+

	+

9	A	M	+	+	+

	10	A	F	+

	+

11	A	F	+	+	+

	12	A	M	+

	+

13	A	M	+	+	+

	14	A	F	+

	+

15	A	M	+	+	+

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

H-100

APPENDIX H - FETAL OBSERVATIONS

(INDIVIDUAL FETAL OBSERVATIONS)

(SEE LIST OF ABBREVIATIONS FOR ABBREVIATIONS)

TARGET DOSE: 20,000 MG/M3

ANIMAL NUMBER:  IGL970

NUMBER OF FETUSES WITH EXTERNAL VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH VISCERAL  VARIATIONS:   	0           MALFORMATIONS:  	0

NUMBER OF FETUSES WITH SKELETAL VARIATIONS:   	2           MALFORMATIONS:   	0

FETUS

NO.

STATUS

SEX

EXTERNAL	VISCERAL

SKELETAL

HEAD	ABDOMEN/THORAX

	1	A	F	+

	+

2	A	F	+	+	+

	3	A	M	+

	+

4	A	M	+	+	+

	5	A	F	+

	+

6	A	F	+	+	+

	   7C	A	F	+

	+

8	A	F	+	+	+

	9	A	F	+

	+

10	A	F	+	+	+

	11	A	M	+

	+

12	A	M	+	+	+

	13	A	F	+

	(a)

14	A	M	+	+	+

	15	A	M	+

	(b)

A = ALIVE	M = MALE	E = EARLY RESORPTION	C = CERVIX

D = DEAD	F = FEMALE	L = LATE RESORPTION		+ = NO OBSERVABLE ABNORMALITIES

NOTE:

(a) - SKELETAL/RIBS (L1): Rudimentary; Bilateral

(b) - SKELETAL/RIBS (L1): Rudimentary; Left

H-101

APPENDIX I  -  INHALATION EXPOSURE DATA

TABLE OF CONTENTS

EXPOSURE CHAMBERS 		I-2

TEST ATMOSPHERE GENERATION		I-2

CHAMBER ENVIRONMENTAL CONDITIONS		I-2

ANALYTICAL PROCEDURES 		I-3

CHAMBER HOMOGENEITY 		I-4

LIGHTING, NOISE, AND OXYGEN LEVELS		I-4

PARTICLE SIZE ANALYSIS		I-4

TABLES

TABLE I-1 -  MEAN EXPOSURE DATA		I-7

TABLE  I-2 - GAS CHROMATOGRAPH OPERATING CONDITIONS		I-8

TABLE  I-3 - SUMMARY OF EXPOSURE DATA		I-10

TABLE  I-4 - SUMMARY OF CHAMBER DISTRIBUTION SAMPLES		I-19

TABLE  I-5 - LIGHTING, NOISE, AND OXYGEN LEVELS		I-20

TABLE  I-6 - PARTICLE SIZE DATA		I-21

TABLE  I-7 – CHAMBER TEMPERATURES AND HUMIDITIES		I-23

FIGURES

FIGURE  I-1 - SCHEMATIC OF GENERATION AND EXPOSURE SYSTEM		I-5

FIGURE  I-2 - SCHEMATIC OF ANALYTICAL CALIBRATION SYSTEM		I-6

FIGURE  I-3 - ANALYTICAL CALIBRATION RESPONSE CURVES		I-9

I-1

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

Exposure Chambers

	The chambers used in this study were constructed of stainless steel and glass and had a total volume of approximately 1.0 m3.  They were operated at an airflow rate of 200 liters per minute ensuring 12 air changes per hour and a theoretical equilibration time (T99) of 23 minutes.  The chamber volume and airflow were considered adequate to ensure an oxygen level greater than 19% and an animal loading below 5%.  The chamber airflow rate was monitored continuously with a calibrated flow-limiting orifice and differential pressure gauge and recorded approximately every 30 minutes.  All of the chambers were maintained at a slight negative pressure to the room.

Test Atmosphere Generation

	Figure I-1 presents a schematic of the test atmosphere generation and exposure system.

Aliquots of the test substance for use in the daily conduct of the study were received in gas cylinders (~20 L nominal volume) via a specially constructed distribution manifold.  The manifold system maintained the test substance under nitrogen pressure,  ensuring that the transferred substance remained in liquid phase and retained the same composition as the original container.

The test substance was delivered via a diptube from the outlet valve of the cylinder to a variable area rotameter which regulated the rate of liquid flow into a heated glass round-bottom flask.  The test substance volatilized within the flask and the resulting vapors mixed with the supply air as they were drawn into the exposure chamber.

Chamber Environmental Conditions

Chamber temperature and humidity were monitored by wet/dry bulb hygrometers and recorded at approximately thirty minute intervals throughout each exposure.

I-2

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

Analytical Procedures

Schematic of the analytical calibration system: Figure I-2.

Analytical calibration response curves: Figure I-3

Gas chromatograph operating conditions: Table I-2

Mean exposure data: Table I-1

Summary of exposure data: Table I-3

	Exposure concentrations were determined on both a nominal and analytical basis.  Nominal concentrations for each exposure level were calculated by weighing the tank containing the test substance before and after exposure and dividing the net loss in weight by the total volume of air passing through the chamber during the exposure.

	Analytical exposure concentrations were determined hourly during each exposure by on-line gas chromatography (Hewlett Packard 6890).  Samples of the chamber atmosphere were continuously delivered to the GC via 1/8” Teflon tubing connected to an automated 12-port multiposition gas sampling valve.  The multiposition valve was programmed to sequentially direct each stream to a sample loop which injected a fixed sample volume (2 cc) directly onto the column for analysis.  A complete sampling cycle was performed during each hour of exposure.

	The analytical system was calibrated against a series of known concentrations of the test substance in air.  The air concentrations were determined by injecting a weighed amount of the test substance from a gas-tight syringe into a closed loop system of a known air volume (see schematic of drawing).  The closed loop system consisted of an infrared vapor analyzer (MIRAN 1A-CVF, Foxboro Analytical)  connected to the gas sampling valve of the GC.  A metal bellows pump was used to circulate the injected test substance vapors through the sample cell of the infrared monitor and the gas sampling valve of the GC.  The response of the infrared analyzer was monitored until the air concentration appeared equilibrated and stable,  then three replicate samples were taken using the gas sample loop of the GC.  The entire closed loop system was cleared with clean air between each calibration injection.  The average response of the GC (total peak area) for the four main constituents of the atmosphere, at each air concentration was used to construct a linear calibration for the test substance.

	This method permitted the GC and the infrared analyzer (a backup analytical method) to be calibrated simultaneously and  under conditions similar to actual chamber sampling.  Once established, the calibration was checked daily during the study by sampling a certified standard of n-butane, the major component of the test substance mixture.

I-3

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

Chamber Homogeneity

	Table I-4 presents a summary of the chamber distribution data.

	During the method development trials for this study, samples were drawn from twelve different points within the chamber at each target concentration to demonstrate the homogeneity of test atmosphere distribution.

Lighting, Noise and Oxygen Levels

	Table I-5 presents a summary of the lighting, noise, and oxygen level data.

Light intensity was measured three times during the study (the first day of exposures, during the second week of exposures, and the last day of exposures) in both the animal room and the chamber room.  Light intensity was measured in the animal room in a cage approximately three feet above the floor level.  In the chamber room the light intensity was measured three feet above floor level in the approximate center of each generation room.

Additionally, the oxygen level and the noise level were measured in each exposure chamber on the first day of exposures, during the second week of exposures, and on the last day of exposures.

Particle Size Analysis

	Table I-6 presents a summary of the particle size data.

A particle size determination of the aerosol portion of the test atmosphere was conducted during the chamber trials from the control and 20,000 mg/m3 concentration chambers.  The sample was taken using a multistage cascade impactor.  Preweighed glass fiber filters were used to collect aerosol on each stage, which are associated with specific cutoff diameters for aerodynamic particle size in microns.  Since minimal aerosol was present, no further calculations were performed for the aerodynamic diameter, geometric standard deviation, or the estimated percents of the aerosol less than or equal to 1, 10, and 15 microns in size.

I-4

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

FIGURE I-1  -  SCHEMATIC OF GENERATION AND EXPOSURE SYSTEM

I-5

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

FIGURE I-2  -  SCHEMATIC OF THE ANALYTICAL CALIBRATION SYSTEM

I-6

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE I-1  - MEAN EXPOSURE DATA

GROUP:	1	2	3	4

Target Exposure Concentration

(mg/m3)

0

2000

10000

20000

Mean Analytical Exposure Concentration

(mg/m3)

0

2020

10395	20772

Average Chamber Temperature

(OF)	72	72	75	72

Average Chamber Relative Humidity

(% RH)	62	62	57	62

I-7

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE I-2  -  GAS CHROMATOGRAPH OPERATING CONDITIONS

GAS CHROMATOGRAPH:	Hewlett Packard 6890GC

DETECTOR:	Flame Ionization

COLUMN:	Supelco Part # 13867, MTO-SS, 2M 1/8”,

	Carbopack C 80/100 0.19% Picric Acid 15g

GAS FLOWS (cc/min):	H2  -  45.0

	Air  -  450.0

	Makeup Gas (Helium)  -  30.0

INLET TEMPERATURE:	100oC

INLET FLOW (cc/min)	Helium - 19.8

OVEN TEMPERATURE:	110oC

DETECTOR TEMPERATURE:	250oC

SAMPLE LOOP SIZE:	2 cc

ATTENUATION:	0

RUN TIME:	8.5 Minutes

I-8

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

FIGURE  I-3 - ANALYTICAL CALIBRATION RESPONSE CURVES

I-9

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE I-3  -  SUMMARY OF EXPOSURE DATA

	Group 1	Group 2	Group 3	Group 4

Date	Mean	Nominal	Chamber	Mean	Nominal	Chamber	Mean	Nominal	Chamber	Mean Nominal	Chamber

	(mg/m3)	(mg/m3)	oF	% Rh	(mg/m3)	(mg/m3)	oF	% Rh	(mg/m3)	(mg/m3)	oF	% Rh (mg/m3)	(mg/m3)	oF	% Rh

31-Aug-02	0	0	70	65	2033	1769	70	65	10406	9643	73	58	20818	18599	70	65

1-Sep-02	0	0	68	72	1717	1813	70	64	10337	10169	72	58	20672	19218	71	59

2-Sep-02	0	0	72	59	2099	1832	70	65	10120	9858	73	60	20835	19068	70	65

3-Sep-02	0	0	72	66	1968	1969	70	65	10244	10071	74	60	20232	19019	70	72

4-Sep-02	0	0	72	66	2053	1931	72	63	10181	9906	75	60	20693	18597	72	63

5-Sep-02	0	0	72	64	2122	1864	72	66	10440	10063	76	59	20775	18788	72	63

6-Sep-02	0	0	73	59	2144	1890	72	61	10127	9686	75	54	20609	18649	73	61

7-Sep-02	0	0	71	64	2045	1693	70	67	10381	9882	73	65	20982	19475	72	65

8-Sep-02	0	0	72	66	2053	1932	72	66	10004	8976	73	60	20113	17335	74	60

9-Sep-02	0	0	72	64	1950	1713	71	60	10498	9978	76	57	21048	18050	73	61

10-Sep-02	0	0	74	60	2075	1803	73	67	10410	9914	77	55	19881	17846	74	61

11-Sep-02	0	0	74	60	2040	1906	74	57	10465	9919	76	56	20627	18458	74	58

12-Sep-02	0	0	74	50	2077	1963	73	53	10373	9790	77	47	21534	18379	73	52

13-Sep-02	0	0	75	54	2054	2028	75	54	10088	9928	77	54	21140	18874	74	56

14-Sep-02	0	0	73	73	1995	1701	72	70	10622	10125	75	60	20629	18376	72	69

15-Sep-02	0	0	74	59	2092	1986	74	59	10882	10047	74	66	21371	18872	72	66

16-Sep-02	0	0	73	75	1911	1993	73	70	10117	9778	76	64	20451	18822	72	71

17-Sep-02	0	0	74	60	1738	2094	73	60	10676	9597	77	56	21153	18017	73	61

18-Sep-02	0	0	73	61	2065	1899	73	60	10578	9942	77	55	21214	18249	73	62

19-Sep-02	0	0	72	58	2065	1796	72	65	10687	9964	76	60	20885	18261	72	62

20-Sep-02	0	0	72	62	2119	1899	71	63	10676	9907	76	54	21065	18129	72	60

21-Sep-02	0	0	72	66	2069	2057	71	72	10359	10107	76	59	21177	19008	72	63

22-Sep-02	0	0	71	59	2137	2029	70	64	9985	9701	75	54	20245	18556	72	61

23-Sep-02	0	0	73	58	2054	1715	72	58	10539	10053	76	54	20858	18779	72	60

24-Sep-02	0	0	72	57	1893	1683	72	55	10530	9944	76	49	20905	18521	72	58

25-Sep-02	0	0	71	58	1991	1814	71	58	10402	9867	75	52	20321	18371	71	59

26-Sep-02	0	0	71	64	1973	1833	71	59	10542	10026	75	54	20606	18517	70	62

MEAN	0	0	72	62	2020	1874	72	62	10395	9883	75	57	20772	18549	72	62

s.d.	0	0	1.5	5.6	105.6	118.6	1.4	4.9	228.5	233.5	1.5	4.4	394.4	454.3	1.2 4.3

Minimum	0	0	68	50	1717	1683	70	53	9985	8976	72	47	19881	17335	70	52

Maximum	0	0	75	75	2144	2094	75	72	10882	10169	77	66	21534	19475	74	72

I-10

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE I-3 (CONT’D)  -  SUMMARY OF EXPOSURE DATA

GROUP 1  -  0 mg/m3

Nominal	Mean Analytical 	Mean	Mean

	Exposure	Concentration	Concentration	Temperature	Relative Humidity

Date	Number	(mg/m3)	(mg/m3)	(oF)	(%)

31-Aug-02	1	0	0	70	65

1-Sep-02	2	0	0	68	72

2-Sep-02	3	0	0	72	59

3-Sep-02	4	0	0	72	66

4-Sep-02	5	0	0	72	66

5-Sep-02	6	0	0	72	64

6-Sep-02	7	0	0	73	59

7-Sep-02	8	0	0	71	64

8-Sep-02	9	0	0	72	66

9-Sep-02	10	0	0	72	64

10-Sep-02	11	0	0	74	60

11-Sep-02	12	0	0	74	60

12-Sep-02	13	0	0	74	50

13-Sep-02	14	0	0	75	54

14-Sep-02	15	0	0	73	73

I-11

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE I-3 (CONT’D)  -  SUMMARY OF EXPOSURE DATA

GROUP 1  -  0 mg/m3

Nominal	Mean Analytical 	Mean	Mean

	Exposure	Concentration	Concentration	Temperature	Relative Humidity

Date	Number	(mg/m3)	(mg/m3)	(oF)	(%)

15-Sep-02	16	0	0	74	59

16-Sep-02	17	0	0	73	75

17-Sep-02	18	0	0	74	60

18-Sep-02	19	0	0	73	61

19-Sep-02	20	0	0	72	58

20-Sep-02	21	0	0	72	62

21-Sep-02	22	0	0	72	66

22-Sep-02	23	0	0	71	59

23-Sep-02	24	0	0	73	58

24-Sep-02	25	0	0	72	57

25-Sep-02	26	0	0	71	58

26-Sep-02	27	0	0	71	64

MEAN

0	0	72	62

Std. Dev.

0.0	0.0	1.5	5.6

I-12

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE I-3 (CONT’D)  -  SUMMARY OF EXPOSURE DATA

GROUP 2  -  2000 mg/m3 TARGET

Nominal

	Mean 	Mean	Mean

	Exposure	Conc.	Hourly Analytical Concentrations (mg/m3)	Concentration Temperature	Relative

Date	Number	(mg/m3)	1	2	3	4	5	6	(mg/m3)	(oF)	Humidity (%)

31-Aug-02	1	1769	2184	2070	2003	1993	1947	2003	2033	70	65

1-Sep-02	2	1813	1848	2021	1978	1921	1844	688	1717	70	64

2-Sep-02	3	1832	2035	2382	1814	2048	2081	2231	2099	70	65

3-Sep-02	4	1969	1984	2086	2090	2170	1276	2200	1968	70	65

4-Sep-02	5	1931	1845	2167	2185	2119	1585	2414	2053	72	63

5-Sep-02	6	1864	1830	2279	1958	2108	1888	2670	2122	72	66

6-Sep-02	7	1890	2447	2169	1995	2111	2007	2135	2144	72	61

7-Sep-02	8	1693	1867	2014	1973	2199	2040	2178	2045	70	67

8-Sep-02	9	1932	2188	1893	2192	2030	2011	2004	2053	72	66

9-Sep-02	10	1713	2044	1928	2173	1882	2269	1405	1950	71	60

10-Sep-02	11	1803	1866	1980	2145	2094	2268	2098	2075	73	67

11-Sep-02	12	1906	1988	2075	2056	1998	1983	2138	2040	74	57

12-Sep-02	13	1963	1954	2074	2237	1617	2423	2160	2077	73	53

13-Sep-02	14	2028	1889	2374	2029	1639	2290	2106	2054	75	54

14-Sep-02	15	1701	2089	1942	1964	2070	2026	1880	1995	72	70

I-13

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE I-3 (CONT’D)  -  SUMMARY OF EXPOSURE DATA

GROUP 2  -  2000 mg/m3 TARGET

Nominal

	Mean 	Mean	Mean

	Exposure	Conc.	Hourly Analytical Concentrations (mg/m3)	Concentration Temperature	Relative

Date	Number	(mg/m3)	1	2	3	4	5	6	(mg/m3)	(oF)	Humidity (%)

15-Sep-02	16	1986	2313	2317	1645	2032	2206	2036	2092	74	59

16-Sep-02	17	1993	2034	2219	673*	2529	1948	2065	1911	73	70

17-Sep-02	18	2094	2074	2172	2159	1707	0*	2318	1738	73	60

18-Sep-02	19	1899	2069	2149	1304	2353	2126	2389	2065	73	60

19-Sep-02	20	1796	2080	2125	2189	1807	2231	1959	2065	72	65

20-Sep-02	21	1899	2067	2186	2066	2160	2110	2127	2119	71	63

21-Sep-02	22	2057	1992	2024	2231	2025	2335	1809	2069	71	72

22-Sep-02	23	2029	1096	3441	1862	2004	1957	2462	2137	70	64

23-Sep-02	24	1715	2176	2101	2012	2041	2052	1940	2054	72	58

24-Sep-02	25	1683	1964	2041	2154	1288	1692	2218	1893	72	55

25-Sep-02	26	1814	1767	2244	2045	1990	1788	2114	1991	71	58

26-Sep-02	27	1833	2316	1973	2320	1611	1722	1897	1973	71	59

MEAN

1874

	2020	72	62

Std. Dev.

188.6

	105.6	1.4	4.9

* Float in Rotameter stuck due to air bubble.

I-14

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE I-3 (CONT’D)  -  SUMMARY OF EXPOSURE DATA

GROUP 3 -  10000 mg/m3 TARGET

Nominal

	Mean	Mean	Mean

Exposure	Conc.	Hourly Analytical Concentration (mg/m3)	Concentration Temperature	Relative

Date	Number	(mg/m3)	1	2	3	4	5	6	(mg/m3)	(oF)	Humidity (%)

31-Aug-02	1	9643	10496	10382	10653	10467	10257	10180	10406	73	58

1-Sep-02	2	10169	10447	10322	10134	10477	9761	10882	10337	72	58

2-Sep-02	3	9858	10100	10353	9360	9466	10171	11269	10120	73	60

3-Sep-02	4	10071	9729	10104	9675	10419	10548	10990	10244	74	60

4-Sep-02	5	9906	9075	10538	10500	10155	10211	10608	10181	75	60

5-Sep-02	6	10063	9755	10651	10704	10243	10362	10925	10440	76	59

6-Sep-02	7	9686	8985	8149	10852	10937	10904	10932	10127	75	54

7-Sep-02	8	9882	9915	9865	10758	10612	10145	10990	10381	73	65

8-Sep-02	9	8976	10209	9338	8600	10390	10801	10686	10004	73	60

9-Sep-02	10	9978	9297	10666	10519	10258	11491	10756	10498	76	57

10-Sep-02	11	9914	10134	10457	10229	10107	10952	10584	10410	77	55

11-Sep-02	12	9919	10182	10528	10494	10570	10575	10444	10465	76	56

12-Sep-02	13	9790	10412	10675	10462	10143	10329	10216	10373	77	47

13-Sep-02	14	9928	9654	9953	10367	10095	10253	10201	10088	77	54

14-Sep-02	15	10125	9951	10234	10302	11391	11150	10703	10622	75	60

I-15

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE I-3 (CONT’D)  -  SUMMARY OF EXPOSURE DATA

GROUP 3  -  10000 mg/m3 TARGET

Nominal

	Mean 	Mean	Mean

	Exposure	Conc.	Hourly Analytical Concentration (mg/m3)	Concentration Temperature	Relative

Date	Number	(mg/m3)	1	2	3	4	5	6	(mg/m3)	(oF)	Humidity (%)

15-Sep-02	16	10047	10563	11142	10419	11200	11054	10915	10882	74	66

16-Sep-02	17	9778	10200	10074	9607	10669	9865	10286	10117	76	64

17-Sep-02	18	9597	11123	10115	10442	10939	10630	10806	10676	77	56

18-Sep-02	19	9942	10321	10890	10481	10819	10538	10419	10578	77	55

19-Sep-02	20	9964	10379	10721	10964	10639	10653	10770	10687	76	60

20-Sep-02	21	9907	10413	10713	10610	10601	10630	11091	10676	76	54

21-Sep-02	22	10107	9898	10208	10398	10656	10326	10668	10359	76	59

22-Sep-02	23	9701	9839	10287	9563	10291	10090	9839	9985	75	54

23-Sep-02	24	10053	9640	10351	10530	10562	11216	10932	10539	76	54

24-Sep-02	25	9944	10258	10663	10677	10530	10243	10807	10530	76	49

25-Sep-02	26	9867	9838	10416	10646	10305	10570	10636	10402	75	52

26-Sep-02	27	10026	10804	10590	10600	10510	10449	10298	10542	75	54

MEAN

9883

	10395	75	57

Std. Dev.

233.5

	228.5	1.5	4.4

I-16

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE I-3 (CONT’D)  -  SUMMARY OF EXPOSURE DATA

GROUP 4 -  20000 mg/m3 TARGET

Nominal

	Mean	Mean	Mean

Exposure	Conc.	Hourly Analytical Concentration (mg/m3)	Concentration Temperature	Relative

Date	Number	(mg/m3)	1	2	3	4	5	6	(mg/m3)	(oF)	Humidity (%)

31-Aug-02	1	18599	21320	20363	20750	21099	20557	20820	20818	70	65

1-Sep-02	2	19218	20842	20220	20722	21788	20621	19840	20672	71	59

2-Sep-02	3	19068	20315	21067	20810	20192	21359	21270	20835	70	65

3-Sep-02	4	19019	19266	19397	19965	21027	20975	20762	20232	70	72

4-Sep-02	5	18597	19956	20784	20782	21122	21224	20290	20693	72	63

5-Sep-02	6	18788	19689	21885	21201	19713	20896	21270	20775	72	63

6-Sep-02	7	18649	21128	18951	21063	20881	21028	20604	20609	73	61

7-Sep-02	8	19475	19953	20539	20356	21399	21952	21692	20982	72	65

8-Sep-02	9	17335	12042	20955	22457	22071	21568	21586	20113	74	60

9-Sep-02	10	18050	20824	20103	21996	19951	22239	21176	21048	73	61

10-Sep-02	11	17846	20996	20877	17155	19774	20454	20033	19881	74	61

11-Sep-02	12	18458	20632	20219	20425	20809	20834	20841	20627	74	58

12-Sep-02	13	18379	20888	21603	21980	21764	21794	21177	21534	73	52

13-Sep-02	14	18874	21120	20823	21496	21155	20839	21409	21140	74	56

14-Sep-02	15	18376	20665	19309	20635	21251	20984	20933	20629	72	69

I-17

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE I-3 (CONT’D)  -  SUMMARY OF EXPOSURE DATA

GROUP 4  -  20000 mg/m3 TARGET

Nominal

	Mean 	Mean	Mean

	Exposure	Conc.	Hourly Analytical Concentration (mg/m3)	Concentration Temperature	Relative

Date	Number	(mg/m3)	1	2	3	4	5	6	(mg/m3)	(oF)	Humidity (%)

15-Sep-02	16	18872	21093	20876	20980	21661	21928	21688	21371	72	66

16-Sep-02	17	18822	19855	20041	20268	21158	20858	20527	20451	72	71

17-Sep-02	18	18017	21155	19119	21415	22411	22184	20634	21153	73	61

18-Sep-02	19	18249	20942	21483	21178	21971	20813	20895	21214	73	62

19-Sep-02	20	18261	20377	20401	20567	22117	21265	20583	20885	72	62

20-Sep-02	21	18129	21162	20801	20484	21046	20803	22092	21065	72	60

21-Sep-02	22	19008	20793	21628	20296	19370	22830	22146	21177	72	63

22-Sep-02	23	18556	20195	20268	19625	20361	20390	20633	20245	72	61

23-Sep-02	24	18779	19867	21049	20971	20752	20333	22173	20858	72	60

24-Sep-02	25	18521	20619	20596	20388	21168	20841	21818	20905	72	58

25-Sep-02	26	18371	19760	19887	21441	19970	20437	20432	20321	71	59

26-Sep-02	27	18517	20417	19685	21616	20845	20662	20408	20606	70	62

MEAN

18549

	20772	72	62

Std. Dev.

454.3

	394.4	1.2	4.3

I-18

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE  I-4 - SUMMARY OF DISTRIBUTION SAMPLES

SAMPLE	TARGET EXPOSURE LEVELS

LOCATION	2000 MG/M3	10,000 MG/M3	20,000 MG/M3

Left Top Back	1918	10296	20555

Left Top Front	2038	10572	20473

Left Middle Back	2011	10121	20625

Left Middle Front	2017	10236	20415

Left Bottom Back	1910	9865	20691

Left Bottom Front	1939	9845	20905

Right Top Back	1941	10034	21990

Right Top Front	2027	10972	21142

Right Middle Back	1941	10606	20536

Right Middle Front	1972	10881	21053

Right Bottom Back	1912	10610	20903

Right Bottom Front	1996	10312	20642

MEAN	1968	10362	20828

SD	47.3	370.4	433.0

%CV	2.4	3.6	2.1

Minimum	1910	9845	20415

Maximum	2038	10972	21990

                                                     NOTE:  top, middle, bottom sample locations represent horizontal planes within exposure chamber.  Left, right, front, back represent

                  	corners of each horizontal plane.  Samples taken in series at approximately 8 minute intervals.

I-19

APPENDIX I  -  INHALATION EXPOSURE DATA (CONT'D)

TABLE I-5 LIGHTING, NOISE, AND OXYGEN LEVELS

Environmental Conditions

	August 31, 2002	September 18, 2002	September 26, 2002

Light Intensity: (fc)

	Room PE103  in a cage 3 feet above the floor.	11.1	11.8	7.31a

Center of room PE 102, 3 feet above the floor.	33.4	38.5	43.7

Room PE 110, 3 feet above the floor.	32.8	33.4	31.2

Noise level:  (db)

	1m - 1: Door open	78.7	76.3	79.5

1m - 1: Through port	80.1	82.2	82.9

1m - 2: Door open	78.5	75.8	75.3