SEQ CHAPTER \h \r 1

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

DATE:  	13 June 2007

SUBJECT:	Pyraclostrobin. Amended Acute and Chronic Aggregate Dietary and Drinking Water Exposure and Risk Assessments to Support New Use on Cotton, Belgian Endive, and Increased Tolerance on the Berries Crop Group

PC Code:	099100		Decision Number: 362283

DP Number:	340582

REVIEWER:	Leung Cheng, Chemist

Registration Action Branch 3

Health Effects Division (7509P)

THROUGH:	Felecia Fort, Chemist

David Soderberg, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

and

Paula Deschamp, Branch Chief

Registration Action Branch 3

Health Effects Division (7509P)

TO:		Barry O’Keefe, Risk Assessor

		Registration Action Branch 3

		Health Effects Division (7509P)

Note: The revised memorandum describes the acute and chronic dietary exposure analyses resulting from raising the recommended tolerance in/on Belgian endive from 6 ppm to 11 ppm. See DP# 339733, 5/30/07, J. Stokes.

Executive Summary

Acute and chronic dietary risk assessments were conducted using the Dietary Exposure Evaluation Model (DEEM-FCID™, Version 2.03), which uses food consumption data from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. The analyses were performed to support a new use on cotton and an increase in the berry group tolerance.

Acute Dietary Exposure Results and Characterization

The acute dietary analysis was based on tolerance level or highest residues and 100% crop treated assumptions for all commodities. Experimentally derived processing factors were used for fruit juices and tomato and wheat commodities.

The drinking water values used in the acute dietary risk assessment were based on information provided by Environmental Fate and Effects Division (EFED). Exposure to pyraclostrobin (parent only) was significantly higher in the surface water (10.2 ppb) than ground water (0.02 ppb).

The results of the acute dietary analysis for food only indicate that acute dietary risks (food only) do not exceed HED’s level of concern (less than 100% of the acute population adjusted dose (aPAD)) for the U.S. population and all subgroups. At the 95th percentile, the U.S. population has an exposure from food only that results in a risk that is estimated at < 2% of the aPAD.  The most highly exposed subpopulation is “females 13-49 years” due to a substantially more sensitive endpoint.  At the 95th percentile, this subpopulation has an exposure from food only that results in a risk estimated at 78% of the aPAD.

The results of the aggregate acute dietary analysis for food and water indicate that acute dietary risks (food and water) do not exceed HED’s level of concern (less than 100% of the acute population adjusted dose (aPAD)) for the U.S. population and all subgroups. At the 95th percentile, the U.S. population has an exposure from food and water that results in a risk estimate that is practically unchanged from that from food only (at <2% of the aPAD).  The most highly exposed subpopulation is “females 13-49 years”. At the 95th percentile, this population subgroup has an exposure from food and water that is essentially the same as from food only.

The acute dietary exposure analysis is still quite conservative even though the highest residue values for certain crops and experimental factors for the major consumed juices have been used in estimating the exposure to various subgroups, keeping in mind that a hundred percent of all the crops is assumed to have been treated with pyraclostrobin.

Chronic Dietary Exposure Results and Characterization

The chronic dietary analysis included tolerance level or average residues from field trial data and 100% crop treated assumptions for all commodities.  Experimentally derived processing factors were used for fruit juices and tomato and wheat commodities.

The drinking water values used in the chronic dietary risk assessment were based on information provided by EFED.  Exposure to pyraclostrobin was higher in the surface water (0.8 ppb) than ground water (0.02 ppb).

The results of the chronic dietary analysis for food only indicate that chronic dietary risks (food only) do not exceed HED’s level of concern (less than 100% of the chronic population adjusted dose (cPAD)) for the U.S. population and all subgroups.  The U.S. population exposure from food only results in a risk that is estimated at 19% of the cPAD.  The most highly exposed population subgroup is “children 1-2 years of age” with an exposure that results in a risk estimated at 47% of the cPAD.

The results of the aggregate chronic dietary analysis for food and water indicate that chronic dietary risks (food and water) do not exceed HED’s level of concern for the U.S. population and all subgroups.  The U.S. population exposure from food and water results in a risk that is estimated at 19% of the cPAD.  The most highly exposed population subgroup is “children 1-2 years of age” with an exposure that results in a risk estimated at 48% of the cPAD.

Cancer Dietary Exposure Results and Characterization

HED has determined that it is no longer appropriate to regulate cancer risk for pyraclostrobin using an MOE approach since the CARC recently concluded the chemical to be “not likely to be carcinogenic to humans” (TXR# 54516, 2/15/2007).

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population adjusted dose (PAD).  The PAD is equivalent to the reference dose point of departure (POD, NOAEL, LOAEL) divided by the required uncertainty and safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  HED is generally concerned when estimated cancer risk exceeds one in one million (i.e., the risk exceeds 1 x 10-6).  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link:      HYPERLINK "http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf"  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see SOP 99.6 (8/20/99).

The most recent dietary risk assessment for pyraclostrobin was conducted by L. Cheng (11/30/2005, DP # 323630).

II.	Residue Information

Pyraclostrobin tolerances have been established in 40 CFR §180.582.  Tolerances for plant commodities are listed in 40 CFR §180.582 (a)(1) in terms of the combined residues of the fungicide pyraclostrobin (carbamic acid, [2-[[[1-(4-chlorophenyl)-1H- pyrazol-3-yl]oxy]methyl]phenyl]methoxy-, methyl ester) and its desmethoxy metabolite methyl 2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]phenyl carbamate, expressed as parent compound.  The established tolerances for plant commodities range from 0.20 ppm (wheat grain; 0.02 ppm is a typographical error in the 40CFR) to 27 ppm (grass seed screenings).  Recently, HED has recommended for granting permanent tolerances at 0.3 ppm on undelinted cottonseed and 30 ppm on cotton gin byproducts, 6 ppm on Belgian endive, and increasing the current tolerance level for the berries crop group from 1.3 ppm to 4.0 ppm (DP# 337807, J. Stokes, 03/30/2007). However, HED revised the recommended tolerance level for Belgian endive from 6 ppm to 11 ppm in a subsequent memo (DP# 339733, J. Stokes, 05/30/2007).

Residue Data used for Acute, Chronic, and/or Cancer Assessments:

For the acute dietary analysis, tolerance level or highest field trial residues were used for all crops. One hundred percent crop treated was assumed for all commodities in the assessment. Default processing factors were applied to all commodities except for apple juice, grape juice, citrus juices, cottonseed oil, tomato paste, tomato puree, wheat flour, and wheat germ where experimental factors were used.

For the chronic dietary analysis, average field trial residue values were used for certain crops (tomato, pepper, citrus, apple, leaf lettuce, head lettuce), which are the major dietary contributors based on preliminary runs. One hundred percent crop treated was assumed for all commodities in the assessment. Experimentally derived processing factors for apple juice, grape juice, citrus juices, cottonseed oil, tomato paste, tomato puree, wheat flour, and wheat germ were applied.

A summary of the data source and residue estimates for crops that differ from the corresponding tolerance level and default processing factors for both acute and chronic assessments is tabulated in Attachment 1.

There are several key changes to the dietary risk assessment from the previous analysis dated 11/30/2005.

1)	Percent crop treated information is no longer applied in the current chronic assessment.

2)	Anticipated residues were derived for the following crops in the chronic assessment: apple, grape, head lettuce, leaf lettuce, celery, spinach, orange, pepper, and tomato.

3)	A cancer risk assessment has not been conducted since cancer is no longer a concern for this chemical.

 Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) in the following memorandum: “Drinking Water Assessment for the Use of Pyraclostrobin (P.C. Code: 099100) on Undelinted Cotton Seed, Cotton Gin By-Products, and Berries Group 13” (A. Al-Mudallal, D326246, 2/21/2007) and incorporated directly into this dietary assessment.  EFED concluded that the proposed use rates are much lower than the use rate on turf, the site that was selected for the drinking water assessment. Therefore, the estimated concentrations in drinking water associated with the previous Section 3 request for the use of pyraclostrobin in-furrow on potatoes remain valid (D303496, 10/6/2004). Water residues were incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.”

The drinking water assessment provides Tier II (PRZM 3.12/EXAMS 2.7.97) surface water modeling and Tier I (SCI-GROW) groundwater modeling. The modeling was conducted for the parent compound only. The residue concentrations from Tier II surface water modeling are not expected to exceed 10.2 µg/L for the peak concentration, 0.8 µg/L for the annual average concentration, and 0.5 µg/L for the 30 year average concentration. Residue concentration from Tier I groundwater modeling is not expected to exceed 0.02 µg/L. The model and its description are available at the EPA internet site:   HYPERLINK "http://www.epa.gov/oppefed1/models/water/"  http://www.epa.gov/oppefed1/models/water/ .

IV.	DEEM-FCID™ Program and Consumption Information

Pyraclostrobin acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID™, Version 2.03), which incorporates consumption data from USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, for tiers 1 and 2, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

V.	Toxicological Information

In the latest Cancer Assesement Review Committee (CARC) meeting that was held on 2/1/2007, the Committee concluded that female mice had been tested adequately at the top dose (at 180 ppm) in the carcinogenicity study upon evaluation of the supplemental mouse data at the 360 ppm dose (TXR # 54516, 2/15/2007). Previously, the CARC considered that the doses tested in both sexes of the rat carcinogenicity study were adequate, and confirmed that the tumor data from the combined results of carcinogenicity and chronic toxicity studies (in rats) showed neither a significant increasing trend nor a significant difference in the pair-wise comparison of the dosed groups with the controls; however, the CARC concluded that the available data were inadequate to make the determination of the carcinogenic potential of pyraclostrobin in B6C3F1 mice, and recommended that the study in female mice be repeated at adequate dose levels. The report of the CARC of October 22, 2003 (Report of the Cancer Assessment Review Committee (Second Evaluation); PC Code: 099100.  Memorandum from J. Kidwell to G. Dannan, B. O’Keefe, J. Bazuin and C. Giles-Parker, October 22, 2003) supersedes that CPRC report (see below).

For the endpoint selection, the Hazard Identification Assessment Review Committee (HIARC) met on December 17, 2002 to reevaluate the potential for increased susceptibility of infants and children vis-á-vis the FQPA safety factor for pyraclostrobin.  Previous endpoints and conclusions made at the July 31, 2001 and June 25, 2002 HIARC meetings were unchanged (HED documents 014669 and 0050932). The HED HIARC also considered the registrant’s (BASF) request to waive the requirement for a 28-day inhalation toxicity study with pyraclostrobin and the registrant’s responses to previous HIARC recommendations to repeat two guideline studies because of inadequate dosing.  The third HIARC for pyraclostrobin confirmed the conclusions of the HED Carcinogenicity Peer Review Committee (CPRC) report of December 26, 2001 (TXT No. 0050363) that classified pyraclostrobin into the category “Data are inadequate to assess the human carcinogenic potential” because of incomplete examination of male rats for hemolymphoreticular and testicular tumors and inadequate testing of female rats and female mice.

Thus, the CARC concluded that no tumors were seen in either male or female mice, and therefore, the cancer classification is “not likely to be carcinogenic to humans”; cancer quantification is not required.

The toxicity endpoints pertinent for human risk assessment are summarized in Table 1.

Table 1. Summary of Toxicological Doses and Endpoints for Pyraclostrobin for Use in Dietary Human Health Risk Assessments

Exposure/

Scenario	Point of Departure	Uncertainty/FQPA Safety Factors	RfD, PAD, Level of Concern for Risk Assessment	Study and Toxicological Effects

NOTE:  Do not state that an exposure/risk assessment is not required.  Rather, state why no risk is expected from the exposure scenario(s) (e.g., no hazard was identified or no exposure is expected).

Acute Dietary

(Females 13-49 years of age)	NOAEL= 5.0 mg/kg/day	UFA= 10x

UFH= 10x

FQPA SF= 1x

	Acute RfD = 0.05 mg/kg/day

aPAD = 0.05 mg/kg/day	Rabbit Prenatal Developmental Toxicity

LOAEL = 10.0 mg/kg/day based on developmental toxicity findings of increased resorptions.

Acute Dietary (General Population, including Infants and Children)	NOAEL = 300 mg/kg/day	UFA= 10x

UFH= 10x

FQPA SF= 1x 	Acute RfD = 3.0 mg/kg/day

aPAD = 3.0 mg/kg/day	  SEQ CHAPTER \h \r 1 Rat Acute Oral Neurotoxicity

LOAEL = 1000 mg/kg/day based on decreased body weight gain in males.

Chronic Dietary (All Populations)	NOAEL= 3.4 mg/kg/day	UFA= 10x

UFH= 10x

FQPA SF= 1x

	Chronic RfD = 0.034 mg/kg/day

cPAD = 0.034 mg/kg/day	  SEQ CHAPTER \h \r 1 Rat Oral Carcinogenicity

LOAEL = 9.2 mg/kg/day based on decreased body weight/body weight gain, kidney tubular casts and atrophy in both sexes; increased incidence of  liver necrosis and erosion/ulceration of the glandular- stomach and fore-stomach in males.

Cancer (oral) 	Classification:  “Not likely to be Carcinogenic to Humans” based on the absence of significant tumor increases in two adequate rodent carcinogenicity studies.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and  used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures.  NOAEL = no observed adverse effect level.  LOAEL = lowest observed adverse effect level.  UF = uncertainty factor.  UFA = extrapolation from animal to human (intraspecies).  UFH = potential variation in sensitivity among members of the human population (interspecies).  UFL = use of a LOAEL to extrapolate a NOAEL.  UFS = use of a short-term study for long-term risk assessment.  UFDB = to account for the absence of key date (i.e., lack of a critical study).  FQPA SF = FQPA Safety Factor.  PAD = population adjusted dose (a = acute, c = chronic).  RfD = reference dose.  MOE = margin of exposure.  LOC = level of concern.  N/A = not applicable.

VI.	Results/Discussion

Results of Acute Dietary Exposure Analysis

The results of the acute dietary analysis for food only indicate that acute dietary risks (food only) do not exceed HED’s level of concern (less than 100% of the acute population adjusted dose (aPAD)) for the U.S. population and all subgroups.  At the 95th percentile, the U.S. population has an exposure from food only that results in a risk estimated at < 2% of the aPAD.  The most highly exposed subpopulation is “females 13-49 years” due to a substantially more sensitive endpoint.  At the 95th percentile, this population subgroup has an exposure from food only that results in a risk estimated at 78% of the aPAD.

The results of the aggregate acute dietary analysis for food and water indicate that acute dietary risks (food and water) do not exceed HED’s level of concern (less than 100% of the acute population adjusted dose (aPAD)) for the U.S. population and all subgroups. At the 95th percentile, the U.S. population has an exposure from food and water that results in a risk that is practically unchanged at <2% of the aPAD. The most highly exposed subpopulation is “females 13-49 years”. At the 95th percentile, this population subgroup has an exposure from food and water that is without change at 78% of the aPAD.

The results of the acute dietary exposure analysis (with and without water) at the 95th, 99th, and 99.9th percentiles of exposure are reported in Tables 2 and 3, below.

Table 2.  Results of Acute Dietary Exposure Analysis Using  DEEM FCID  - Food Only

Population Subgroup	aPAD (mg/kg/day)	95th Percentile	99th Percentile 99.9th Percentile

Exposure (mg/kg/day)	% aPAD*	Exposure (mg/kg/day)	% aPAD*	Exposure (mg/kg/day)	% aPAD*

General U.S. Population	3.0	0.041	1.4	0.074	2.5	0.15	4.9

All Infants (< 1 year old)	3.0	0.051	1.7	0.17	5.6	0.44	15

Children 1-2 years old	3.0	0.069	2.3	0.13	4.3	0.38	13

Children 3-5 years old	3.0	0.061	2.0	0.11	3.5	0.28	9.3

Children 6-12 years old	3.0	0.045	1.5	0.071	2.4	0.16	5.2

Youth 13-19 years old	3.0	0.034	1.1	0.064	2.1	0.094	3.1

Adults 20-49 years old	3.0	0.037	1.2	0.069	2.3	0.12	4.0

Adults 50+ years old	3.0	0.040	1.3	0.071	2.4	0.13	4.2

Females 13-49 years old 	0.05	0.039	78	0.072	144	0.14	282

*Most highly exposed subgroup is bolded.

Table 3.  Results of Acute Dietary Exposure Analysis Using  DEEM FCID  - Food and Water

Population Subgroup	aPAD (mg/kg/day)	95th Percentile	99th Percentile 99.9th Percentile

Exposure (mg/kg/day)	% aPAD*	Exposure (mg/kg/day)	% aPAD*	Exposure (mg/kg/day)	% aPAD*

General U.S. Population	3.0	0.042	1.4	0.074	2.5	0.15	5.0

All Infants (< 1 year old)	3.0	0.052	1.7	0.17	5.7	0.44	15

Children 1-2 years old	3.0	0.070	2.3	0.13	4.4	0.40	13

Children 3-5 years old	3.0	0.061	2.0	0.11	3.5	0.28	9.4

Children 6-12 years old	3.0	0.045	1.5	0.071	2.4	0.14	4.6

Youth 13-19 years old	3.0	0.034	1.1	0.065	2.2	0.094	3.1

Adults 20-49 years old	3.0	0.037	1.3	0.070	2.3	0.12	4.0

Adults 50+ years old	3.0	0.040	1.3	0.072	2.4	0.13	4.3

Females 13-49 years old 	0.05	0.039	78	0.073	145	0.14	284

* Most highly exposure subgroup is bolded.

Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary analysis for food only indicate that chronic dietary risks (food only) do not exceed HED’s level of concern (less than 100% of the chronic population adjusted dose (cPAD)) for the U.S. population and all subgroups.  The U.S. population exposure from food only results in a risk estimated at 19% of the cPAD.  The most highly exposed is “children 1-2 years of age” with an exposure estimated at 47% of the cPAD.

The results of the aggregate chronic dietary analysis for food and water indicate that chronic dietary risks (food and water) do not exceed HED’s level of concern for the U.S. population and all subgroups.  The U.S. population exposure from food and water results in a risk estimated at 19% of the cPAD.  The most highly exposed population subgroup is “children 1 -2 years old” with an exposure estimated at 48% of the cPAD.

The results of the chronic dietary exposure analysis (with and without water) are reported in Tables 4 and 5, below.

Cancer Dietary Exposure Results and Characterization

As noted above, the HED CARC has recently revisited the cancer classification for pyraclostrobin.  HED has reclassified pyraclostrobin as “not likely to be carcinogenic to humans" and determined that regulation of cancer risk using an MOE approach is no longer appropriate.

Table 4.  Summary of Dietary Exposure and Risk for Pyraclostrobin – Food Only

Population Subgroup	Acute Dietary

(95th Percentile)	Chronic Dietary	Cancer

	Dietary Exposure (mg/kg/day)	% aPAD	Dietary Exposure

(mg/kg/day)	% cPAD	Dietary Exposure

(mg/kg/day)	Risk

General U.S. Population	0.041	1.4	0.0064	19	A separate quantitative cancer risk assessment is not required.

All Infants (< 1 year old)	0.051	1.7	0.0099	29

	Children 1-2 years old	0.069	2.3	0.016	47

	Children 3-5 years old	0.061	2.0	0.012	36

	Children 6-12 years old	0.045	1.5	0.0074	22

	Youth 13-19 years old	0.034	1.1	0.0045	13

	Adults 20-49 years old	0.037	1.2	0.0053	16

	Adults 50+ years old	0.039	1.3	0.0065	19

	Females 13-49 years old	0.039	78	0.0051	15

Table 5.  Summary of Dietary Exposure and Risk for Pyraclostrobin – Food & Water

Population Subgroup	Acute Dietary

(95th Percentile)	Chronic Dietary	Cancer

	Dietary Exposure (mg/kg/day)	% aPAD	Dietary Exposure

(mg/kg/day)	% cPAD	Dietary Exposure

(mg/kg/day)	Risk

General U.S. Population	0.041	1.4	0.0066	19	A separate quantitative cancer risk assessment is not required.

All Infants (< 1 year old)	0.052	1.7	0.010	31

	Children 1-2 years old	0.070	2.3	0.016	48

	Children 3-5 years old	0.061	2.0	0.012	36

	Children 6-12 years old	0.045	1.5	0.0075	22

	Youth 13-19 years old	0.034	1.1	0.0046	14

	Adults 20-49 years old	0.037	1.2	0.0054	16

	Adults 50+ years old	0.040	1.3	0.0066	20

	Females 13-49 years old	0.039	78	0.0053	16

VIII.	Characterization of Inputs/Outputs

The acute and chronic dietary risk assessments are considered only minimally refined.

The acute analysis was conducted using tolerance level residues or the highest residues for all commodities. These tolerance level or highest residues were derived from field trial data conducted at the maximum application rate and minimum PHI permitted on the proposed or existing labels.  For all commodities 100% crop treated was assumed.  A limited number of experimentally derived processing factors were used to refine the acute analysis. Of note is that contribution from drinking water is minimal.  HED concludes that the acute exposure estimates are unlikely to underestimate actual acute exposure.

The chronic dietary assessment was conducted using tolerance level residues for all crops except for apple, grape, head lettuce, leaf lettuce, celery, spinach, orange, pepper, tomato and additional crops in the leafy vegetables group where average residue values were derived from crop field trials.  As noted above, these field trials represent maximum application rates and minimum PHIs.  For all commodities 100% crop treated was assumed.  A limited number of experimentally derived processing factors were used to refine the analysis. Again, contribution from drinking water is minimal. HED concludes that the chronic exposure estimates in this analysis are unlikely to underestimate actual exposure.

IX.  	Conclusions

 using the DEEM-FCID™, Version 2.03, which uses food consumption data from the USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994 – 1996 and 1998.

The acute analysis is considered minimally refined with the incorporation of experimentally determined processing factors for fruit juices and tomato and wheat commodities.  Residue values for all commodities are based on tolerances or highest residues from field trials. All commodities were assumed to be 100% crop treated. The chronic dietary risk assessments were refined by the incorporation of average residues derived from field trial data for apple, grape, head lettuce, leaf lettuce, celery, spinach, orange, pepper and tomato reflecting the maximum label application rate and minimum PHI, as well as by the use of experimental processing factors for fruit juices and tomato and wheat commodities. All commodities were assumed to be 100% crop treated. Additional refinements are possible for both analyses; therefore HED concludes that the acute and chronic dietary exposure analyses are unlikely to underestimate exposure and risk.

Acute and chronic exposures and risks do not exceed HED’s level of concern for the U.S. population. Further, acute and chronic exposures and risks do not exceed HED’s level of concern for all relevant population subgroups.

X.	List of Attachments

Attachment 1.  Data and Residue Estimates Used in Dietary Analysis

Acute Dietary Exposure & Risk

Attachment 2.  Pyraclostrobin Acute Dietary Analysis Input File - Food Only

Attachment 3.  Pyraclostrobin Acute Dietary Analysis Results - Food Only

Attachment 4.  Pyraclostrobin Acute Dietary Analysis Input File - Food & Water

Attachment 5.  Pyraclostrobin Acute Dietary Analysis Results - Food & Water

Chronic Dietary Exposure & Risk

Attachment 6.  Pyraclostrobin Chronic Dietary Analysis Input File - Food Only

Attachment 7.  Pyraclostrobin Chronic Dietary Analysis Results - Food Only

Attachment 8.  Pyraclostrobin Chronic Dietary Analysis Input File - Food & Water

Attachment 9.  Pyraclostrobin Chronic Dietary Analysis Results - Food & Water

cc with attachments:  L. Cheng, S. Piper, P.Y. BarnesAttachment 1.  Data and Residue Estimates Used in Dietary Analyses

Table 6.  Data and Residue Estimates Used in Dietary Analyses

RAC	Classification1	Data

Source	No. of

Samples	No. of

Detectable

Residues	LOD	%CT	Processing

Factors	Anticipated Residue Estimates/Tolerance

Acute (Tol., HR, RDF)	Chronic (Tol., AR)2

Amaranth, leafy	PB	Tolerance & Field Trial Data for spinach 46109101 celery 46109102 head lettuce 45832001	16	16

100	None	HR (23.38)	AR (11.77)

Arugula

	AR (11.77)

Chrysanthemum

	AR (11.77)

Cress, garden

	AR (11.77)

Cress, upland

	AR (11.77)

Dandelion, leaves

	AR (11.77)

Fennel

	AR (5.02)

Parsley, leaves

	AR (11.77)

Radicchio

	AR (0.59)

Rhubarb

	AR (5.02)

Spinach

	AR (11.77)

Swiss chard

	AR (5.02)

Apple	NB, PB	Tolerance & Field Trial Data 45645803	32	32

100	Juice at 0.2x

MRID 45645804	Tol (1.5)	AR (0.31)

Barley	B	Tolerance & Field Trial Data 45118535	25	6	0.04	100	None	Tol (0.40)	Tol (0.40)

Beans, dry	B	Tolerance & Field Trial Data 45367501	20	4	0.04	100	None	HR (0.21)	Tol (0.50)

Celery	NB, PB, B	Tolerance & Field Trial Data 46109102	24	24

100	None	HR (10.7)	AR (5.02)

Citrus (except orange)	NB, PB	Tolerance & Field Trial Data	22	22

100	Juice at 0.02x (45118617)	Tol (2.0)	Tol (2.0)

Grape	PB	Tolerance & Field Trial Data 45118529 45118531	26	26

100	Juice at 0.01x (45118616)	Tol (2.0)	AR (0.768)

Lettuce, head 	NB	Tolerance & Field Trial Data 45832001	5	5

100	None	HR (14.4)	AR (0.59)

Lettuce, leaf	PB	Tolerance & Field Trial Data 45832001	12	12

100	None	HR (20.1)	AR (7.68)

Orange	NB, PB	Tolerance & Field Trial Data 45903601	26	26

100	Juice at 0.02x (45118617)	Tol (2.0)	AR (0.30)

Pea, dry	B	Tolerance & Field Trial Data 45596211	18	13	0.04	100	None	HR (0.10)	Tol (0.50)

Pepper	NB, PB	Tolerance & Field Trial Data 45118611	18	17	0.04	100	None Tol (1.4)	AR (0.232)

Tomato	NB, PB	Tolerance & Field Trial Data 45118528	30	30

100	Paste at 2.1x; Puree at 0.55x (45118615)	Tol (1.4)	AR (0.158)

Wheat

(Triticale)	B	Tolerance & Field Trial Data 45118537 	122	30	0.04	100 Flour at 0.7x; Germ at 0.85x  (45321101)	Tol (0.20)	Tol (0.20)

Remainder

Tolerance & Field Trial Data 40CFR180.582

100	Default	Tol	Tol

Water	N/A	Modeling	N/A	N/A	N/A	N/A	N/A	0.01	0.0008

N/A =  not applicable

1.  	Classification of blended (B), partially blended (PB), not blended (NB).

2.	Chronic ARs are based on LOQ (0.04 ppm)Attachment 2.  Pyraclostrobin Acute Dietary Analysis Input File – Food Only

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for PYRACLOSTROBIN                     1994-98 data

Residue file: C:\Documents and Settings\lcheng\My Documents\DEEM FCID lc\Pyraclostrobin\Tol+HR053007.R98

                                                           Adjust. #2 NOT used

Analysis Date 06-11-2007             Residue file dated: 05-30-2007/16:21:53/8

Reference dose (RfD) = 0.034 mg/kg bw/day

Comment:05-30-07:Tol+HR (endive 11 ppm); aPAD (female)=0.05 mkd

------------------------------------------------------------------------ --------

Food Crop                                       Residue       Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)

                                                             #1         #2

-------- ---- -------------------------------   ---------- ------     ------   -------

14000030 14   Almond                             0.040000   1.000      1.000

14000040 14   Almond, oil                        0.040000   1.000      1.000

04010050 4A   Amaranth, leafy                   23.380000   1.000      1.000

11000070 11   Apple, fruit with peel             1.500000   1.000      1.000

11000080 11   Apple, peeled fruit                1.500000   1.000      1.000

11000081 11   Apple, peeled fruit-babyfood       1.500000   1.000      1.000

11000090 11   Apple, dried                       1.500000   8.000      1.000

11000091 11   Apple, dried-babyfood              1.500000   8.000      1.000

11000100 11   Apple, juice                       1.500000   0.200      1.000

11000101 11   Apple, juice-babyfood              1.500000   0.200      1.000

11000110 11   Apple, sauce                       1.500000   1.000      1.000

11000111 11   Apple, sauce-babyfood              1.500000   1.000      1.000

12000120 12   Apricot                            0.900000   1.000      1.000

12000121 12   Apricot-babyfood                   0.900000   1.000      1.000

12000130 12   Apricot, dried                     0.900000   6.000      1.000

12000140 12   Apricot, juice                     0.900000   1.000      1.000

12000141 12   Apricot, juice-babyfood            0.900000   1.000      1.000

01030150 1CD  Arrowroot, flour                   0.040000   1.000      1.000

01030170 1CD  Artichoke, Jerusalem               0.040000   1.000      1.000

04010180 4A   Arugula                           23.380000   1.000      1.000

09020210 9B   Balsam pear                        0.500000   1.000      1.000

95000230 O    Banana                             0.040000   1.000      1.000

95000231 O    Banana-babyfood                    0.040000   1.000      1.000

95000240 O    Banana, dried                      0.040000   3.900      1.000

95000241 O    Banana, dried-babyfood             0.040000   3.900      1.000

15000250 15   Barley, pearled barley             0.400000   1.000      1.000

15000251 15   Barley, pearled barley-babyfood    0.400000   1.000      1.000

15000260 15   Barley, flour                      0.400000   1.000      1.000

15000261 15   Barley, flour-babyfood             0.400000   1.000      1.000

15000270 15   Barley, bran                       0.400000   1.000      1.000

06030300 6C   Bean, black, seed                  0.210000   1.000      1.000

06020310 6B   Bean, broad, succulent             0.500000   1.000      1.000

06030320 6C   Bean, broad, seed                  0.210000   1.000      1.000

06020330 6B   Bean, cowpea, succulent            0.500000   1.000      1.000

06030340 6C   Bean, cowpea, seed                 0.210000   1.000      1.000

06030350 6C   Bean,  great northern, seed        0.210000   1.000      1.000

06030360 6C   Bean, kidney, seed                 0.210000   1.000      1.000

06020370 6B   Bean, lima, succulent              0.500000   1.000      1.000

06030380 6C   Bean, lima, seed                   0.210000   1.000      1.000

06030390 6C   Bean, mung, seed                   0.210000   1.000      1.000

06030400 6C   Bean, navy, seed                   0.210000   1.000      1.000

06030410 6C   Bean, pink, seed                   0.210000   1.000      1.000

06030420 6C   Bean, pinto, seed                  0.210000   1.000      1.000

06010430 6A   Bean, snap, succulent              0.500000   1.000      1.000

06010431 6A   Bean, snap, succulent-babyfood     0.500000   1.000      1.000

21000440 M    Beef, meat                         0.100000   1.000      1.000

21000441 M    Beef, meat-babyfood                0.100000   1.000      1.000

21000450 M    Beef, meat, dried                  0.100000   1.920      1.000

21000460 M    Beef, meat byproducts              0.200000   1.000      1.000

21000461 M    Beef, meat byproducts-babyfood     0.200000   1.000      1.000

21000470 M    Beef, fat                          0.100000   1.000      1.000

21000471 M    Beef,fat-babyfood                  0.100000   1.000      1.000

21000480 M    Beef, kidney                       0.200000   1.000      1.000

21000490 M    Beef, liver                        1.500000   1.000      1.000

21000491 M    Beef, liver-babyfood               1.500000   1.000      1.000

01010500 1AB  Beet, garden, roots                0.400000   1.000      1.000

01010501 1AB  Beet, garden, roots-babyfood       0.400000   1.000      1.000

02000510 2    Beet, garden, tops                16.000000   1.000      1.000

01010520 1A   Beet, sugar                        0.200000   0.400      1.000

01010521 1A   Beet, sugar-babyfood               0.200000   0.400      1.000

01010530 1A   Beet, sugar, molasses              0.200000   0.400      1.000

01010531 1A   Beet, sugar, molasses-babyfood     0.200000   0.400      1.000

95000540 O    Belgium endive                    11.000000   1.000      1.000

13010550 13A  Blackberry                         4.000000   1.000      1.000

13010560 13A  Blackberry, juice                  4.000000   1.000      1.000

13010561 13A  Blackberry, juice-babyfood         4.000000   1.000      1.000

13020570 13B  Blueberry                          4.000000   1.000      1.000

13020571 13B  Blueberry-babyfood                 4.000000   1.000      1.000

13010580 13A  Boysenberry                        4.000000   1.000      1.000

14000590 14   Brazil nut                         0.040000   1.000      1.000

05010610 5A   Broccoli                           5.000000   1.000      1.000

05010611 5A   Broccoli-babyfood                  5.000000   1.000      1.000

05010620 5A   Broccoli, Chinese                  5.000000   1.000      1.000

05020630 5B   Broccoli raab                     16.000000   1.000      1.000

05010640 5A   Brussels sprouts                   5.000000   1.000      1.000

01010670 1AB  Burdock                            0.400000   1.000      1.000

14000680 14   Butternut                          0.040000   1.000      1.000

05010690 5A   Cabbage                            5.000000   1.000      1.000

05020700 5B   Cabbage, Chinese, bok choy        16.000000   1.000      1.000

05010710 5A   Cabbage, Chinese, napa             5.000000   1.000      1.000

05010720 5A   Cabbage, Chinese, mustard          5.000000   1.000      1.000

09010750 9A   Cantaloupe                         0.500000   1.000      1.000

04020760 4B   Cardoon                           23.380000   1.000      1.000

01010780 1AB  Carrot                             0.400000   1.000      1.000

01010781 1AB  Carrot-babyfood                    0.400000   1.000      1.000

01010790 1AB  Carrot, juice                      0.400000   1.000      1.000

09010800 9A   Casaba                             0.500000   1.000      1.000

14000810 14   Cashew                             0.040000   1.000      1.000

01030820 1CD  Cassava                            0.040000   1.000      1.000

01030821 1CD  Cassava-babyfood                   0.040000   1.000      1.000

05010830 5A   Cauliflower                        5.000000   1.000      1.000

01010840 1AB  Celeriac                           0.400000   1.000      1.000

04020850 4B   Celery                            10.700000   1.000      1.000

04020851 4B   Celery-babyfood                   10.700000   1.000      1.000

04020860 4B   Celery, juice                     10.700000   1.000      1.000

04020870 4B   Celtuce                           10.700000   1.000      1.000

09020880 9B   Chayote, fruit                     0.500000   1.000      1.000

12000900 12   Cherry                             0.900000   1.000      1.000

12000901 12   Cherry-babyfood                    0.900000   1.000      1.000

12000910 12   Cherry, juice                      0.900000   1.500      1.000

12000911 12   Cherry, juice-babyfood             0.900000   1.500      1.000

14000920 14   Chestnut                           0.040000   1.000      1.000

06030980 6C   Chickpea, seed                     0.340000   1.000      1.000

06030981 6C   Chickpea, seed-babyfood            0.340000   1.000      1.000

06030990 6C   Chickpea, flour                    0.340000   1.000      1.000

01011000 1AB  Chicory, roots                     0.400000   1.000      1.000

02001010 2    Chicory, tops                     16.000000   1.000      1.000

09021020 9B   Chinese waxgourd                   0.500000   1.000      1.000

04011040 4A   Chrysanthemum, garland            23.380000   1.000      1.000

10001060 10   Citrus citron                      2.000000   1.000      1.000

10001070 10   Citrus hybrids                     2.000000   1.000      1.000

10001080 10   Citrus, oil                        9.000000   1.000      1.000

05021170 5B   Collards                          16.000000   1.000      1.000

15001200 15   Corn, field, flour                 0.100000   1.000      1.000

15001201 15   Corn, field, flour-babyfood        0.100000   1.000      1.000

15001210 15   Corn, field, meal                  0.100000   1.000      1.000

15001211 15   Corn, field, meal-babyfood         0.100000   1.000      1.000

15001220 15   Corn, field, bran                  0.100000   1.000      1.000

15001230 15   Corn, field, starch                0.100000   1.000      1.000

15001231 15   Corn, field, starch-babyfood       0.100000   1.000      1.000

15001250 15   Corn, field, oil                   0.300000   1.000      1.000

15001251 15   Corn, field, oil-babyfood          0.300000   1.000      1.000

15001260 15   Corn, pop                          0.100000   1.000      1.000

15001270 15   Corn, sweet                        0.040000   1.000      1.000

15001271 15   Corn, sweet-babyfood               0.040000   1.000      1.000

95001280 O    Cottonseed, oil                    0.300000   1.000      1.000

95001281 O    Cottonseed, oil-babyfood           0.300000   1.000      1.000

11001290 11   Crabapple                          1.500000   1.000      1.000

04011330 4A   Cress, garden                     23.380000   1.000      1.000

04011340 4A   Cress, upland                     23.380000   1.000      1.000

09021350 9B   Cucumber                           0.500000   1.000      1.000

13021360 13B  Currant                            4.000000   1.000      1.000

13021370 13B  Currant, dried                     4.000000   1.000      1.000

04011380 4A   Dandelion, leaves                 23.380000   1.000      1.000

01031390 1CD  Dasheen, corm                      0.040000   1.000      1.000

02001400 2    Dasheen, leaves                   16.000000   1.000      1.000

13011420 13A  Dewberry                           4.000000   1.000      1.000

08001480 8    Eggplant                           1.400000   1.000      1.000

13021490 13B  Elderberry                         4.000000   1.000      1.000

04011500 4A   Endive                            23.380000   1.000      1.000

04021520 4B   Fennel, Florence                  23.380000   1.000      1.000

14001550 14   Filbert                            0.040000   1.000      1.000

03001640 3    Garlic                             0.900000   1.000      1.000

03001650 3    Garlic, dried                      0.900000   1.000      1.000

03001651 3    Garlic, dried-babyfood             0.900000   1.000      1.000

01031660 1CD  Ginger                             0.040000   1.000      1.000

01031670 1CD  Ginger, dried                      0.040000   1.000      1.000

01011680 1AB  Ginseng, dried                     0.400000   1.000      1.000

23001690 M    Goat, meat                         0.100000   1.000      1.000

23001710 M    Goat, fat                          0.100000   1.000      1.000

13021740 13B  Gooseberry                         4.000000   1.000      1.000

95001750 O    Grape                              2.000000   1.000      1.000

95001760 O    Grape, juice                       2.000000   0.010      1.000

95001761 O    Grape, juice-babyfood              2.000000   0.010      1.000

95001770 O    Grape, leaves                      2.000000   1.000      1.000

95001780 O    Grape, raisin                      7.000000   1.000      1.000

95001790 O    Grape, wine and sherry             2.000000   1.000      1.000

10001800 10   Grapefruit                         2.000000   1.000      1.000

10001810 10   Grapefruit, juice                  2.000000   0.020      1.000

06031820 6C   Guar, seed                         0.340000   1.000      1.000

06031821 6C   Guar, seed-babyfood                0.340000   1.000      1.000

09011870 9A   Honeydew melon                     0.500000   1.000      1.000

95001880 O    Hop                               23.000000   1.000      1.000

01011900 1AB  Horseradish                        0.400000   1.000      1.000

13021910 13B  Huckleberry                        4.000000   1.000      1.000

05021940 5B   Kale                              16.000000   1.000      1.000

05011960 5A   Kohlrabi                           5.000000   1.000      1.000

10001970 10   Kumquat                            2.000000   1.000      1.000

03001980 3    Leek                               0.900000   1.000      1.000

10001990 10   Lemon                              2.000000   1.000      1.000

10002000 10   Lemon, juice                       2.000000   0.020      1.000

10002001 10   Lemon, juice-babyfood              2.000000   0.020      1.000

10002010 10   Lemon, peel                        2.000000   1.000      1.000

06032030 6C   Lentil, seed                       0.340000   1.000      1.000

04012040 4A   Lettuce, head                     14.400000   1.000      1.000

04012050 4A   Lettuce, leaf                     20.100000   1.000      1.000

10002060 10   Lime                               2.000000   1.000      1.000

10002070 10   Lime, juice                        2.000000   0.020      1.000

10002071 10   Lime, juice-babyfood               2.000000   0.020      1.000

13012080 13A  Loganberry                         4.000000   1.000      1.000

11002100 11   Loquat                             1.500000   1.000      1.000

14002130 14   Macadamia nut                      0.040000   1.000      1.000

95002150 O    Mango                              0.100000   1.000      1.000

95002151 O    Mango-babyfood                     0.100000   1.000      1.000

95002160 O    Mango, dried                       0.100000   1.000      1.000

95002170 O    Mango, juice                       0.100000   1.000      1.000

95002171 O    Mango, juice-babyfood              0.100000   1.000      1.000

27002220 D    Milk, fat                          0.100000   1.000      1.000

27002221 D    Milk, fat - baby food/infant for   0.100000   1.000      1.000

27012230 D    Milk, nonfat solids                0.100000   1.000      1.000

27012231 D    Milk, nonfat solids-baby food/in   0.100000   1.000      1.000

27022240 D    Milk, water                        0.100000   1.000      1.000

27022241 D    Milk, water-babyfood/infant form   0.100000   1.000      1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.100000   1.000      1.000

05022290 5B   Mustard greens                    16.000000   1.000      1.000

12002300 12   Nectarine                          0.900000   1.000      1.000

08002340 8    Okra                               1.400000   1.000      1.000

03002370 3    Onion, dry bulb                    0.900000   1.000      1.000

03002371 3    Onion, dry bulb-babyfood           0.900000   1.000      1.000

03002380 3    Onion, dry bulb, dried             0.900000   9.000      1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.900000   9.000      1.000

03002390 3    Onion, green                       0.900000   1.000      1.000

10002400 10   Orange                             2.000000   1.000      1.000

10002410 10   Orange, juice                      2.000000   0.020      1.000

10002411 10   Orange, juice-babyfood             2.000000   0.020      1.000

10002420 10   Orange, peel                       2.000000   1.000      1.000

95002450 O    Papaya                             0.100000   1.000      1.000

95002451 O    Papaya-babyfood                    0.100000   1.000      1.000

95002460 O    Papaya, dried                      0.100000   1.800      1.000

95002470 O    Papaya, juice                      0.100000   1.500      1.000

04012480 4A   Parsley, leaves                   23.380000   1.000      1.000

01012500 1AB  Parsley, turnip rooted             0.400000   1.000      1.000

01012510 1AB  Parsnip                            0.400000   1.000      1.000

01012511 1AB  Parsnip-babyfood                   0.400000   1.000      1.000

06022550 6B   Pea, succulent                     0.200000   1.000      1.000

06022551 6B   Pea, succulent-babyfood            0.200000   1.000      1.000

06032560 6C   Pea, dry                           0.100000   1.000      1.000

06032561 6C   Pea, dry-babyfood                  0.100000   1.000      1.000

06012570 6A   Pea, edible podded, succulent      0.500000   1.000      1.000

06032580 6C   Pea, pigeon, seed                  0.100000   1.000      1.000

06022590 6B   Pea, pigeon, succulent             0.200000   1.000      1.000

12002600 12   Peach                              0.900000   1.000      1.000

12002601 12   Peach-babyfood                     0.900000   1.000      1.000

12002610 12   Peach, dried                       0.900000   7.000      1.000

12002620 12   Peach, juice                       0.900000   1.000      1.000

12002621 12   Peach, juice-babyfood              0.900000   1.000      1.000

95002630 O    Peanut                             0.050000   1.000      1.000

95002640 O    Peanut, butter                     0.050000   1.890      1.000

95002650 O    Peanut, oil                        0.100000   1.900      1.000

11002660 11   Pear                               1.500000   1.000      1.000

11002661 11   Pear-babyfood                      1.500000   1.000      1.000

11002670 11   Pear, dried                        1.500000   6.250      1.000

11002680 11   Pear, juice                        1.500000   1.000      1.000

11002681 11   Pear, juice-babyfood               1.500000   1.000      1.000

14002690 14   Pecan                              0.040000   1.000      1.000

08002700 8    Pepper, bell                       1.400000   1.000      1.000

08002710 8    Pepper, bell, dried                1.400000   1.000      1.000

08002711 8    Pepper, bell, dried-babyfood       1.400000   1.000      1.000

08002720 8    Pepper, nonbell                    1.400000   1.000      1.000

08002721 8    Pepper, nonbell-babyfood           1.400000   1.000      1.000

08002730 8    Pepper, nonbell, dried             1.400000   1.000      1.000

95002750 O    Peppermint                         8.000000   1.000      1.000

95002760 O    Peppermint, oil                    8.000000   1.000      1.000

14002820 14   Pistachio                          0.700000   1.000      1.000

95002830 O    Plantain                           0.040000   1.000      1.000

95002840 O    Plantain, dried                    0.040000   3.900      1.000

12002850 12   Plum                               0.900000   1.000      1.000

12002851 12   Plum-babyfood                      0.900000   1.000      1.000

12002860 12   Plum, prune, fresh                 0.900000   1.000      1.000

12002861 12   Plum, prune, fresh-babyfood        0.900000   1.000      1.000

12002870 12   Plum, prune, dried                 0.900000   1.300      1.000

12002880 12   Plum, prune, juice                 0.900000   1.400      1.000

12002881 12   Plum, prune, juice-babyfood        0.900000   1.400      1.000

25002900 M    Pork, meat                         0.100000   1.000      1.000

25002901 M    Pork, meat-babyfood                0.100000   1.000      1.000

25002910 M    Pork, skin                         0.100000   1.000      1.000

25002920 M    Pork, meat byproducts              0.200000   1.000      1.000

25002921 M    Pork, meat byproducts-babyfood     0.200000   1.000      1.000

25002930 M    Pork, fat                          0.100000   1.000      1.000

25002931 M    Pork, fat-babyfood                 0.100000   1.000      1.000

25002940 M    Pork, kidney                       0.200000   1.000      1.000

25002950 M    Pork, liver                        1.500000   1.000      1.000

01032960 1C   Potato, chips                      0.040000   1.000      1.000

01032970 1C   Potato, dry (granules/ flakes)     0.040000   6.500      1.000

01032971 1C   Potato, dry (granules/ flakes)-b   0.040000   6.500      1.000

01032980 1C   Potato, flour                      0.040000   1.000      1.000

01032981 1C   Potato, flour-babyfood             0.040000   1.000      1.000

01032990 1C   Potato, tuber, w/peel              0.040000   1.000      1.000

01033000 1C   Potato, tuber, w/o peel            0.040000   1.000      1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.040000   1.000      1.000

10003070 10   Pummelo                            2.000000   1.000      1.000

09023080 9B   Pumpkin                            0.500000   1.000      1.000

09023090 9B   Pumpkin, seed                      0.500000   1.000      1.000

11003100 11   Quince                             1.500000   1.000      1.000

04013130 4A   Radicchio                         23.380000   1.000      1.000

01013140 1AB  Radish, roots                      0.400000   1.000      1.000

01013160 1AB  Radish, Oriental, roots            0.400000   1.000      1.000

05023180 5B   Rape greens                       16.000000   1.000      1.000

13013200 13A  Raspberry                          4.000000   1.000      1.000

13013201 13A  Raspberry-babyfood                 4.000000   1.000      1.000

13013210 13A  Raspberry, juice                   4.000000   1.000      1.000

13013211 13A  Raspberry, juice-babyfood          4.000000   1.000      1.000

04023220 4B   Rhubarb                           23.380000   1.000      1.000

01013270 1AB  Rutabaga                           0.400000   1.000      1.000

15003280 15   Rye, grain                         0.040000   1.000      1.000

01013310 1AB  Salsify, roots                     0.400000   1.000      1.000

03003380 3    Shallot                            0.900000   1.000      1.000

26003390 M    Sheep, meat                        0.100000   1.000      1.000

26003391 M    Sheep, meat-babyfood               0.100000   1.000      1.000

26003400 M    Sheep, meat byproducts             0.200000   1.000      1.000

26003410 M    Sheep, fat                         0.100000   1.000      1.000

26003411 M    Sheep, fat-babyfood                0.100000   1.000      1.000

26003420 M    Sheep, kidney                      0.200000   1.000      1.000

26003430 M    Sheep, liver                       1.500000   1.000      1.000

06003470 6    Soybean, seed                      0.040000   1.000      1.000

06003480 6    Soybean, flour                     0.040000   1.000      1.000

06003481 6    Soybean, flour-babyfood            0.040000   1.000      1.000

06003490 6    Soybean, soy milk                  0.040000   1.000      1.000

06003491 6    Soybean, soy milk-babyfood or in   0.040000   1.000      1.000

06003500 6    Soybean, oil                       0.040000   0.800      1.000

06003501 6    Soybean, oil-babyfood              0.040000   0.800      1.000

95003520 O    Spearmint                          8.000000   1.000      1.000

95003530 O    Spearmint, oil                     8.000000   1.000      1.000

04013550 4A   Spinach                           23.380000   1.000      1.000

04013551 4A   Spinach-babyfood                  23.380000   1.000      1.000

09023560 9B   Squash, summer                     0.500000   1.000      1.000

09023561 9B   Squash, summer-babyfood            0.500000   1.000      1.000

09023570 9B   Squash, winter                     0.500000   1.000      1.000

09023571 9B   Squash, winter-babyfood            0.500000   1.000      1.000

95003590 O    Strawberry                         1.200000   1.000      1.000

95003591 O    Strawberry-babyfood                1.200000   1.000      1.000

95003600 O    Strawberry, juice                  1.200000   1.000      1.000

95003601 O    Strawberry, juice-babyfood         1.200000   1.000      1.000

20003640 20   Sunflower, seed                    0.300000   1.000      1.000

20003650 20   Sunflower, oil                     0.300000   1.000      1.000

20003651 20   Sunflower, oil-babyfood            0.300000   1.000      1.000

01033660 1CD  Sweet potato                       0.040000   1.000      1.000

01033661 1CD  Sweet potato-babyfood              0.040000   1.000      1.000

04023670 4B   Swiss chard                       23.380000   1.000      1.000

10003690 10   Tangerine                          2.000000   1.000      1.000

10003700 10   Tangerine, juice                   2.000000   0.020      1.000

01033710 1CD  Tanier, corm                       0.040000   1.000      1.000

08003740 8    Tomatillo                          1.400000   1.000      1.000

08003750 8    Tomato                             1.400000   1.000      1.000

08003751 8    Tomato-babyfood                    1.400000   1.000      1.000

08003760 8    Tomato, paste                      1.400000   2.100      1.000

08003761 8    Tomato, paste-babyfood             1.400000   2.100      1.000

08003770 8    Tomato, puree                      1.400000   0.550      1.000

08003771 8    Tomato, puree-babyfood             1.400000   0.550      1.000

08003780 8    Tomato, dried                      1.400000  14.300      1.000

08003781 8    Tomato, dried-babyfood             1.400000  14.300      1.000

08003790 8    Tomato, juice                      1.400000   1.500      1.000

15003810 15   Triticale, flour                   0.200000   0.700      1.000

01033870 1CD  Turmeric                           0.040000   1.000      1.000

01013880 1AB  Turnip, roots                      0.400000   1.000      1.000

05023890 5B   Turnip, greens                    16.000000   1.000      1.000

14003910 14   Walnut                             0.040000   1.000      1.000

09013990 9A   Watermelon                         0.500000   1.000      1.000

09014000 9A   Watermelon, juice                  0.500000   1.000      1.000

15004010 15   Wheat, grain                       0.200000   1.000      1.000

15004011 15   Wheat, grain-babyfood              0.200000   1.000      1.000

15004020 15   Wheat, flour                       0.200000   0.700      1.000

15004021 15   Wheat, flour-babyfood              0.200000   0.700      1.000

15004030 15   Wheat, germ                        0.200000   0.850      1.000

15004040 15   Wheat, bran                        0.200000   1.000      1.000

01034060 1CD  Yam, true                          0.040000   1.000      1.000

01034070 1CD  Yam bean                           0.040000   1.000      1.000

Attachment 3.  Pyraclostrobin Acute Dietary Analysis Results – Food Only

U.S. Environmental Protection Agency                                  Ver. 2.02

DEEM-FCID ACUTE Analysis for PYRACLOSTROBIN                      (1994-98 data)

Residue file: Tol+HR053007.R98                    Adjustment factor #2 NOT used.

Analysis Date: 06-11-2007/09:57:53    Residue file dated: 05-30-2007/16:21:53/8

NOEL (Acute) = 300.000000 mg/kg body-wt/day

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Daily totals for food and foodform consumption used.

Run Comment: "05-30-07:Tol+HR (endive 11 ppm); aPAD (female)=0.05 mkd"

======================================================================== =======

Summary calculations (per capita):

      95th Percentile             99th Percentile             99.9th Percentile

 Exposure  % aPAD     MOE    Exposure  % aPAD     MOE    Exposure  % aPAD     MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

U.S. Population:

  0.041382    1.38    7249    0.074068    2.47    4050    0.148102    4.94    2025

All infants:

  0.051248    1.71    5853    0.166389    5.55    1802    0.443568   14.79     676

Children 1-2 yrs:

  0.069006    2.30    4347    0.128955    4.30    2326    0.376992   12.57     795

Children 3-5 yrs:

  0.060887    2.03    4927    0.105045    3.50    2855    0.280288    9.34    1070

Children 6-12 yrs:

  0.044656    1.49    6717    0.071005    2.37    4225    0.156044    5.20    1922

Youth 13-19 yrs:

  0.033649    1.12    8915    0.063560    2.12    4719    0.093901    3.13    3194

Adults 20-49 yrs:

  0.037193    1.24    8066    0.069214    2.31    4334    0.119599    3.99    2508

Adults 50+ yrs:

  0.039514    1.32    7592    0.071479    2.38    4197    0.126633    4.22    2369

Females 13-49 yrs:

  0.039064   78.13    7679    0.072212  144.42    4154    0.140986  281.97    2127

Attachment 4.  Pyraclostrobin Acute Dietary Analysis Input File – Food & Water

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for PYRACLOSTROBIN                     1994-98 data

Residue file: C:\Documents and Settings\lcheng\My Documents\DEEM FCID lc\Pyraclostrobin\Tol+HR+water053007.R98

                                                           Adjust. #2 NOT used

Analysis Date 06-11-2007             Residue file dated: 05-30-2007/16:19:31/8

Reference dose (RfD) = 0.034 mg/kg bw/day

Comment:05-30-07: Tol+HR+water (endive 11 ppm); aPAD (female)=0.05 mkd

------------------------------------------------------------------------ --------

Food Crop                                       Residue       Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)

                                                             #1         #2

-------- ---- -------------------------------   ---------- ------     ------   -------

14000030 14   Almond                             0.040000   1.000      1.000

14000040 14   Almond, oil                        0.040000   1.000      1.000

04010050 4A   Amaranth, leafy                   23.380000   1.000      1.000

11000070 11   Apple, fruit with peel             1.500000   1.000      1.000

11000080 11   Apple, peeled fruit                1.500000   1.000      1.000

11000081 11   Apple, peeled fruit-babyfood       1.500000   1.000      1.000

11000090 11   Apple, dried                       1.500000   8.000      1.000

11000091 11   Apple, dried-babyfood              1.500000   8.000      1.000

11000100 11   Apple, juice                       1.500000   0.200      1.000

11000101 11   Apple, juice-babyfood              1.500000   0.200      1.000

11000110 11   Apple, sauce                       1.500000   1.000      1.000

11000111 11   Apple, sauce-babyfood              1.500000   1.000      1.000

12000120 12   Apricot                            0.900000   1.000      1.000

12000121 12   Apricot-babyfood                   0.900000   1.000      1.000

12000130 12   Apricot, dried                     0.900000   6.000      1.000

12000140 12   Apricot, juice                     0.900000   1.000      1.000

12000141 12   Apricot, juice-babyfood            0.900000   1.000      1.000

01030150 1CD  Arrowroot, flour                   0.040000   1.000      1.000

01030170 1CD  Artichoke, Jerusalem               0.040000   1.000      1.000

04010180 4A   Arugula                           23.380000   1.000      1.000

09020210 9B   Balsam pear                        0.500000   1.000      1.000

95000230 O    Banana                             0.040000   1.000      1.000

95000231 O    Banana-babyfood                    0.040000   1.000      1.000

95000240 O    Banana, dried                      0.040000   3.900      1.000

95000241 O    Banana, dried-babyfood             0.040000   3.900      1.000

15000250 15   Barley, pearled barley             0.400000   1.000      1.000

15000251 15   Barley, pearled barley-babyfood    0.400000   1.000      1.000

15000260 15   Barley, flour                      0.400000   1.000      1.000

15000261 15   Barley, flour-babyfood             0.400000   1.000      1.000

15000270 15   Barley, bran                       0.400000   1.000      1.000

06030300 6C   Bean, black, seed                  0.210000   1.000      1.000

06020310 6B   Bean, broad, succulent             0.500000   1.000      1.000

06030320 6C   Bean, broad, seed                  0.210000   1.000      1.000

06020330 6B   Bean, cowpea, succulent            0.500000   1.000      1.000

06030340 6C   Bean, cowpea, seed                 0.210000   1.000      1.000

06030350 6C   Bean,  great northern, seed        0.210000   1.000      1.000

06030360 6C   Bean, kidney, seed                 0.210000   1.000      1.000

06020370 6B   Bean, lima, succulent              0.500000   1.000      1.000

06030380 6C   Bean, lima, seed                   0.210000   1.000      1.000

06030390 6C   Bean, mung, seed                   0.210000   1.000      1.000

06030400 6C   Bean, navy, seed                   0.210000   1.000      1.000

06030410 6C   Bean, pink, seed                   0.210000   1.000      1.000

06030420 6C   Bean, pinto, seed                  0.210000   1.000      1.000

06010430 6A   Bean, snap, succulent              0.500000   1.000      1.000

06010431 6A   Bean, snap, succulent-babyfood     0.500000   1.000      1.000

21000440 M    Beef, meat                         0.100000   1.000      1.000

21000441 M    Beef, meat-babyfood                0.100000   1.000      1.000

21000450 M    Beef, meat, dried                  0.100000   1.920      1.000

21000460 M    Beef, meat byproducts              0.200000   1.000      1.000

21000461 M    Beef, meat byproducts-babyfood     0.200000   1.000      1.000

21000470 M    Beef, fat                          0.100000   1.000      1.000

21000471 M    Beef,fat-babyfood                  0.100000   1.000      1.000

21000480 M    Beef, kidney                       0.200000   1.000      1.000

21000490 M    Beef, liver                        1.500000   1.000      1.000

21000491 M    Beef, liver-babyfood               1.500000   1.000      1.000

01010500 1AB  Beet, garden, roots                0.400000   1.000      1.000

01010501 1AB  Beet, garden, roots-babyfood       0.400000   1.000      1.000

02000510 2    Beet, garden, tops                16.000000   1.000      1.000

01010520 1A   Beet, sugar                        0.200000   0.400      1.000

01010521 1A   Beet, sugar-babyfood               0.200000   0.400      1.000

01010530 1A   Beet, sugar, molasses              0.200000   0.400      1.000

01010531 1A   Beet, sugar, molasses-babyfood     0.200000   0.400      1.000

95000540 O    Belgium endive                    11.000000   1.000      1.000

13010550 13A  Blackberry                         4.000000   1.000      1.000

13010560 13A  Blackberry, juice                  4.000000   1.000      1.000

13010561 13A  Blackberry, juice-babyfood         4.000000   1.000      1.000

13020570 13B  Blueberry                          4.000000   1.000      1.000

13020571 13B  Blueberry-babyfood                 4.000000   1.000      1.000

13010580 13A  Boysenberry                        4.000000   1.000      1.000

14000590 14   Brazil nut                         0.040000   1.000      1.000

05010610 5A   Broccoli                           5.000000   1.000      1.000

05010611 5A   Broccoli-babyfood                  5.000000   1.000      1.000

05010620 5A   Broccoli, Chinese                  5.000000   1.000      1.000

05020630 5B   Broccoli raab                     16.000000   1.000      1.000

05010640 5A   Brussels sprouts                   5.000000   1.000      1.000

01010670 1AB  Burdock                            0.400000   1.000      1.000

14000680 14   Butternut                          0.040000   1.000      1.000

05010690 5A   Cabbage                            5.000000   1.000      1.000

05020700 5B   Cabbage, Chinese, bok choy        16.000000   1.000      1.000

05010710 5A   Cabbage, Chinese, napa             5.000000   1.000      1.000

05010720 5A   Cabbage, Chinese, mustard          5.000000   1.000      1.000

09010750 9A   Cantaloupe                         0.500000   1.000      1.000

04020760 4B   Cardoon                           23.380000   1.000      1.000

01010780 1AB  Carrot                             0.400000   1.000      1.000

01010781 1AB  Carrot-babyfood                    0.400000   1.000      1.000

01010790 1AB  Carrot, juice                      0.400000   1.000      1.000

09010800 9A   Casaba                             0.500000   1.000      1.000

14000810 14   Cashew                             0.040000   1.000      1.000

01030820 1CD  Cassava                            0.040000   1.000      1.000

01030821 1CD  Cassava-babyfood                   0.040000   1.000      1.000

05010830 5A   Cauliflower                        5.000000   1.000      1.000

01010840 1AB  Celeriac                           0.400000   1.000      1.000

04020850 4B   Celery                            10.700000   1.000      1.000

04020851 4B   Celery-babyfood                   10.700000   1.000      1.000

04020860 4B   Celery, juice                     10.700000   1.000      1.000

04020870 4B   Celtuce                           10.700000   1.000      1.000

09020880 9B   Chayote, fruit                     0.500000   1.000      1.000

12000900 12   Cherry                             0.900000   1.000      1.000

12000901 12   Cherry-babyfood                    0.900000   1.000      1.000

12000910 12   Cherry, juice                      0.900000   1.500      1.000

12000911 12   Cherry, juice-babyfood             0.900000   1.500      1.000

14000920 14   Chestnut                           0.040000   1.000      1.000

06030980 6C   Chickpea, seed                     0.340000   1.000      1.000

06030981 6C   Chickpea, seed-babyfood            0.340000   1.000      1.000

06030990 6C   Chickpea, flour                    0.340000   1.000      1.000

01011000 1AB  Chicory, roots                     0.400000   1.000      1.000

02001010 2    Chicory, tops                     16.000000   1.000      1.000

09021020 9B   Chinese waxgourd                   0.500000   1.000      1.000

04011040 4A   Chrysanthemum, garland            23.380000   1.000      1.000

10001060 10   Citrus citron                      2.000000   1.000      1.000

10001070 10   Citrus hybrids                     2.000000   1.000      1.000

10001080 10   Citrus, oil                        9.000000   1.000      1.000

05021170 5B   Collards                          16.000000   1.000      1.000

15001200 15   Corn, field, flour                 0.100000   1.000      1.000

15001201 15   Corn, field, flour-babyfood        0.100000   1.000      1.000

15001210 15   Corn, field, meal                  0.100000   1.000      1.000

15001211 15   Corn, field, meal-babyfood         0.100000   1.000      1.000

15001220 15   Corn, field, bran                  0.100000   1.000      1.000

15001230 15   Corn, field, starch                0.100000   1.000      1.000

15001231 15   Corn, field, starch-babyfood       0.100000   1.000      1.000

15001250 15   Corn, field, oil                   0.300000   1.000      1.000

15001251 15   Corn, field, oil-babyfood          0.300000   1.000      1.000

15001260 15   Corn, pop                          0.100000   1.000      1.000

15001270 15   Corn, sweet                        0.040000   1.000      1.000

15001271 15   Corn, sweet-babyfood               0.040000   1.000      1.000

95001280 O    Cottonseed, oil                    0.300000   1.000      1.000

95001281 O    Cottonseed, oil-babyfood           0.300000   1.000      1.000

11001290 11   Crabapple                          1.500000   1.000      1.000

04011330 4A   Cress, garden                     23.380000   1.000      1.000

04011340 4A   Cress, upland                     23.380000   1.000      1.000

09021350 9B   Cucumber                           0.500000   1.000      1.000

13021360 13B  Currant                            4.000000   1.000      1.000

13021370 13B  Currant, dried                     4.000000   1.000      1.000

04011380 4A   Dandelion, leaves                 23.380000   1.000      1.000

01031390 1CD  Dasheen, corm                      0.040000   1.000      1.000

02001400 2    Dasheen, leaves                   16.000000   1.000      1.000

13011420 13A  Dewberry                           4.000000   1.000      1.000

08001480 8    Eggplant                           1.400000   1.000      1.000

13021490 13B  Elderberry                         4.000000   1.000      1.000

04011500 4A   Endive                            23.380000   1.000      1.000

04021520 4B   Fennel, Florence                  23.380000   1.000      1.000

14001550 14   Filbert                            0.040000   1.000      1.000

03001640 3    Garlic                             0.900000   1.000      1.000

03001650 3    Garlic, dried                      0.900000   1.000      1.000

03001651 3    Garlic, dried-babyfood             0.900000   1.000      1.000

01031660 1CD  Ginger                             0.040000   1.000      1.000

01031670 1CD  Ginger, dried                      0.040000   1.000      1.000

01011680 1AB  Ginseng, dried                     0.400000   1.000      1.000

23001690 M    Goat, meat                         0.100000   1.000      1.000

23001710 M    Goat, fat                          0.100000   1.000      1.000

13021740 13B  Gooseberry                         4.000000   1.000      1.000

95001750 O    Grape                              2.000000   1.000      1.000

95001760 O    Grape, juice                       2.000000   0.010      1.000

95001761 O    Grape, juice-babyfood              2.000000   0.010      1.000

95001770 O    Grape, leaves                      2.000000   1.000      1.000

95001780 O    Grape, raisin                      7.000000   1.000      1.000

95001790 O    Grape, wine and sherry             2.000000   1.000      1.000

10001800 10   Grapefruit                         2.000000   1.000      1.000

10001810 10   Grapefruit, juice                  2.000000   0.020      1.000

06031820 6C   Guar, seed                         0.340000   1.000      1.000

06031821 6C   Guar, seed-babyfood                0.340000   1.000      1.000

09011870 9A   Honeydew melon                     0.500000   1.000      1.000

95001880 O    Hop                               23.000000   1.000      1.000

01011900 1AB  Horseradish                        0.400000   1.000      1.000

13021910 13B  Huckleberry                        4.000000   1.000      1.000

05021940 5B   Kale                              16.000000   1.000      1.000

05011960 5A   Kohlrabi                           5.000000   1.000      1.000

10001970 10   Kumquat                            2.000000   1.000      1.000

03001980 3    Leek                               0.900000   1.000      1.000

10001990 10   Lemon                              2.000000   1.000      1.000

10002000 10   Lemon, juice                       2.000000   0.020      1.000

10002001 10   Lemon, juice-babyfood              2.000000   0.020      1.000

10002010 10   Lemon, peel                        2.000000   1.000      1.000

06032030 6C   Lentil, seed                       0.340000   1.000      1.000

04012040 4A   Lettuce, head                     14.400000   1.000      1.000

04012050 4A   Lettuce, leaf                     20.100000   1.000      1.000

10002060 10   Lime                               2.000000   1.000      1.000

10002070 10   Lime, juice                        2.000000   0.020      1.000

10002071 10   Lime, juice-babyfood               2.000000   0.020      1.000

13012080 13A  Loganberry                         4.000000   1.000      1.000

11002100 11   Loquat                             1.500000   1.000      1.000

14002130 14   Macadamia nut                      0.040000   1.000      1.000

95002150 O    Mango                              0.100000   1.000      1.000

95002151 O    Mango-babyfood                     0.100000   1.000      1.000

95002160 O    Mango, dried                       0.100000   1.000      1.000

95002170 O    Mango, juice                       0.100000   1.000      1.000

95002171 O    Mango, juice-babyfood              0.100000   1.000      1.000

27002220 D    Milk, fat                          0.100000   1.000      1.000

27002221 D    Milk, fat - baby food/infant for   0.100000   1.000      1.000

27012230 D    Milk, nonfat solids                0.100000   1.000      1.000

27012231 D    Milk, nonfat solids-baby food/in   0.100000   1.000      1.000

27022240 D    Milk, water                        0.100000   1.000      1.000

27022241 D    Milk, water-babyfood/infant form   0.100000   1.000      1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.100000   1.000      1.000

05022290 5B   Mustard greens                    16.000000   1.000      1.000

12002300 12   Nectarine                          0.900000   1.000      1.000

08002340 8    Okra                               1.400000   1.000      1.000

03002370 3    Onion, dry bulb                    0.900000   1.000      1.000

03002371 3    Onion, dry bulb-babyfood           0.900000   1.000      1.000

03002380 3    Onion, dry bulb, dried             0.900000   9.000      1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.900000   9.000      1.000

03002390 3    Onion, green                       0.900000   1.000      1.000

10002400 10   Orange                             2.000000   1.000      1.000

10002410 10   Orange, juice                      2.000000   0.020      1.000

10002411 10   Orange, juice-babyfood             2.000000   0.020      1.000

10002420 10   Orange, peel                       2.000000   1.000      1.000

95002450 O    Papaya                             0.100000   1.000      1.000

95002451 O    Papaya-babyfood                    0.100000   1.000      1.000

95002460 O    Papaya, dried                      0.100000   1.800      1.000

95002470 O    Papaya, juice                      0.100000   1.500      1.000

04012480 4A   Parsley, leaves                   23.380000   1.000      1.000

01012500 1AB  Parsley, turnip rooted             0.400000   1.000      1.000

01012510 1AB  Parsnip                            0.400000   1.000      1.000

01012511 1AB  Parsnip-babyfood                   0.400000   1.000      1.000

06022550 6B   Pea, succulent                     0.200000   1.000      1.000

06022551 6B   Pea, succulent-babyfood            0.200000   1.000      1.000

06032560 6C   Pea, dry                           0.100000   1.000      1.000

06032561 6C   Pea, dry-babyfood                  0.100000   1.000      1.000

06012570 6A   Pea, edible podded, succulent      0.500000   1.000      1.000

06032580 6C   Pea, pigeon, seed                  0.100000   1.000      1.000

06022590 6B   Pea, pigeon, succulent             0.200000   1.000      1.000

12002600 12   Peach                              0.900000   1.000      1.000

12002601 12   Peach-babyfood                     0.900000   1.000      1.000

12002610 12   Peach, dried                       0.900000   7.000      1.000

12002620 12   Peach, juice                       0.900000   1.000      1.000

12002621 12   Peach, juice-babyfood              0.900000   1.000      1.000

95002630 O    Peanut                             0.050000   1.000      1.000

95002640 O    Peanut, butter                     0.050000   1.890      1.000

95002650 O    Peanut, oil                        0.100000   1.900      1.000

11002660 11   Pear                               1.500000   1.000      1.000

11002661 11   Pear-babyfood                      1.500000   1.000      1.000

11002670 11   Pear, dried                        1.500000   6.250      1.000

11002680 11   Pear, juice                        1.500000   1.000      1.000

11002681 11   Pear, juice-babyfood               1.500000   1.000      1.000

14002690 14   Pecan                              0.040000   1.000      1.000

08002700 8    Pepper, bell                       1.400000   1.000      1.000

08002710 8    Pepper, bell, dried                1.400000   1.000      1.000

08002711 8    Pepper, bell, dried-babyfood       1.400000   1.000      1.000

08002720 8    Pepper, nonbell                    1.400000   1.000      1.000

08002721 8    Pepper, nonbell-babyfood           1.400000   1.000      1.000

08002730 8    Pepper, nonbell, dried             1.400000   1.000      1.000

95002750 O    Peppermint                         8.000000   1.000      1.000

95002760 O    Peppermint, oil                    8.000000   1.000      1.000

14002820 14   Pistachio                          0.700000   1.000      1.000

95002830 O    Plantain                           0.040000   1.000      1.000

95002840 O    Plantain, dried                    0.040000   3.900      1.000

12002850 12   Plum                               0.900000   1.000      1.000

12002851 12   Plum-babyfood                      0.900000   1.000      1.000

12002860 12   Plum, prune, fresh                 0.900000   1.000      1.000

12002861 12   Plum, prune, fresh-babyfood        0.900000   1.000      1.000

12002870 12   Plum, prune, dried                 0.900000   1.300      1.000

12002880 12   Plum, prune, juice                 0.900000   1.400      1.000

12002881 12   Plum, prune, juice-babyfood        0.900000   1.400      1.000

25002900 M    Pork, meat                         0.100000   1.000      1.000

25002901 M    Pork, meat-babyfood                0.100000   1.000      1.000

25002910 M    Pork, skin                         0.100000   1.000      1.000

25002920 M    Pork, meat byproducts              0.200000   1.000      1.000

25002921 M    Pork, meat byproducts-babyfood     0.200000   1.000      1.000

25002930 M    Pork, fat                          0.100000   1.000      1.000

25002931 M    Pork, fat-babyfood                 0.100000   1.000      1.000

25002940 M    Pork, kidney                       0.200000   1.000      1.000

25002950 M    Pork, liver                        1.500000   1.000      1.000

01032960 1C   Potato, chips                      0.040000   1.000      1.000

01032970 1C   Potato, dry (granules/ flakes)     0.040000   6.500      1.000

01032971 1C   Potato, dry (granules/ flakes)-b   0.040000   6.500      1.000

01032980 1C   Potato, flour                      0.040000   1.000      1.000

01032981 1C   Potato, flour-babyfood             0.040000   1.000      1.000

01032990 1C   Potato, tuber, w/peel              0.040000   1.000      1.000

01033000 1C   Potato, tuber, w/o peel            0.040000   1.000      1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.040000   1.000      1.000

10003070 10   Pummelo                            2.000000   1.000      1.000

09023080 9B   Pumpkin                            0.500000   1.000      1.000

09023090 9B   Pumpkin, seed                      0.500000   1.000      1.000

11003100 11   Quince                             1.500000   1.000      1.000

04013130 4A   Radicchio                         23.380000   1.000      1.000

01013140 1AB  Radish, roots                      0.400000   1.000      1.000

01013160 1AB  Radish, Oriental, roots            0.400000   1.000      1.000

05023180 5B   Rape greens                       16.000000   1.000      1.000

13013200 13A  Raspberry                          4.000000   1.000      1.000

13013201 13A  Raspberry-babyfood                 4.000000   1.000      1.000

13013210 13A  Raspberry, juice                   4.000000   1.000      1.000

13013211 13A  Raspberry, juice-babyfood          4.000000   1.000      1.000

04023220 4B   Rhubarb                           23.380000   1.000      1.000

01013270 1AB  Rutabaga                           0.400000   1.000      1.000

15003280 15   Rye, grain                         0.040000   1.000      1.000

01013310 1AB  Salsify, roots                     0.400000   1.000      1.000

03003380 3    Shallot                            0.900000   1.000      1.000

26003390 M    Sheep, meat                        0.100000   1.000      1.000

26003391 M    Sheep, meat-babyfood               0.100000   1.000      1.000

26003400 M    Sheep, meat byproducts             0.200000   1.000      1.000

26003410 M    Sheep, fat                         0.100000   1.000      1.000

26003411 M    Sheep, fat-babyfood                0.100000   1.000      1.000

26003420 M    Sheep, kidney                      0.200000   1.000      1.000

26003430 M    Sheep, liver                       1.500000   1.000      1.000

06003470 6    Soybean, seed                      0.040000   1.000      1.000

06003480 6    Soybean, flour                     0.040000   1.000      1.000

06003481 6    Soybean, flour-babyfood            0.040000   1.000      1.000

06003490 6    Soybean, soy milk                  0.040000   1.000      1.000

06003491 6    Soybean, soy milk-babyfood or in   0.040000   1.000      1.000

06003500 6    Soybean, oil                       0.040000   0.800      1.000

06003501 6    Soybean, oil-babyfood              0.040000   0.800      1.000

95003520 O    Spearmint                          8.000000   1.000      1.000

95003530 O    Spearmint, oil                     8.000000   1.000      1.000

04013550 4A   Spinach                           23.380000   1.000      1.000

04013551 4A   Spinach-babyfood                  23.380000   1.000      1.000

09023560 9B   Squash, summer                     0.500000   1.000      1.000

09023561 9B   Squash, summer-babyfood            0.500000   1.000      1.000

09023570 9B   Squash, winter                     0.500000   1.000      1.000

09023571 9B   Squash, winter-babyfood            0.500000   1.000      1.000

95003590 O    Strawberry                         1.200000   1.000      1.000

95003591 O    Strawberry-babyfood                1.200000   1.000      1.000

95003600 O    Strawberry, juice                  1.200000   1.000      1.000

95003601 O    Strawberry, juice-babyfood         1.200000   1.000      1.000

20003640 20   Sunflower, seed                    0.300000   1.000      1.000

20003650 20   Sunflower, oil                     0.300000   1.000      1.000

20003651 20   Sunflower, oil-babyfood            0.300000   1.000      1.000

01033660 1CD  Sweet potato                       0.040000   1.000      1.000

01033661 1CD  Sweet potato-babyfood              0.040000   1.000      1.000

04023670 4B   Swiss chard                       23.380000   1.000      1.000

10003690 10   Tangerine                          2.000000   1.000      1.000

10003700 10   Tangerine, juice                   2.000000   0.020      1.000

01033710 1CD  Tanier, corm                       0.040000   1.000      1.000

08003740 8    Tomatillo                          1.400000   1.000      1.000

08003750 8    Tomato                             1.400000   1.000      1.000

08003751 8    Tomato-babyfood                    1.400000   1.000      1.000

08003760 8    Tomato, paste                      1.400000   2.100      1.000

08003761 8    Tomato, paste-babyfood             1.400000   2.100      1.000

08003770 8    Tomato, puree                      1.400000   0.550      1.000

08003771 8    Tomato, puree-babyfood             1.400000   0.550      1.000

08003780 8    Tomato, dried                      1.400000  14.300      1.000

08003781 8    Tomato, dried-babyfood             1.400000  14.300      1.000

08003790 8    Tomato, juice                      1.400000   1.500      1.000

15003810 15   Triticale, flour                   0.200000   0.700      1.000

01033870 1CD  Turmeric                           0.040000   1.000      1.000

01013880 1AB  Turnip, roots                      0.400000   1.000      1.000

05023890 5B   Turnip, greens                    16.000000   1.000      1.000

14003910 14   Walnut                             0.040000   1.000      1.000

86010000 O    Water, direct, all sources         0.010000   1.000      1.000

86020000 O    Water, indirect, all sources       0.010000   1.000      1.000

09013990 9A   Watermelon                         0.500000   1.000      1.000

09014000 9A   Watermelon, juice                  0.500000   1.000      1.000

15004010 15   Wheat, grain                       0.200000   1.000      1.000

15004011 15   Wheat, grain-babyfood              0.200000   1.000      1.000

15004020 15   Wheat, flour                       0.200000   0.700      1.000

15004021 15   Wheat, flour-babyfood              0.200000   0.700      1.000

15004030 15   Wheat, germ                        0.200000   0.850      1.000

15004040 15   Wheat, bran                        0.200000   1.000      1.000

01034060 1CD  Yam, true                          0.040000   1.000      1.000

01034070 1CD  Yam bean                           0.040000   1.000      1.000

Attachment 5.  Pyraclostrobin Acute Dietary Analysis Results – Food & Water

U.S. Environmental Protection Agency                                  Ver. 2.02

DEEM-FCID ACUTE Analysis for PYRACLOSTROBIN                      (1994-98 data)

Residue file: Tol+HR+water053007.R98              Adjustment factor #2 NOT used.

Analysis Date: 06-11-2007/10:04:40    Residue file dated: 05-30-2007/16:19:31/8

NOEL (Acute) = 300.000000 mg/kg body-wt/day

Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports

Daily totals for food and foodform consumption used.

Run Comment: "05-30-07: Tol+HR+water (endive 11 ppm); aPAD (female)=0.05 mkd"

======================================================================== =======

Summary calculations (per capita):

      95th Percentile             99th Percentile             99.9th Percentile

 Exposure  % aPAD     MOE    Exposure  % aPAD     MOE    Exposure  % aPAD     MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

U.S. Population:

  0.041515    1.38    7226    0.074304    2.48    4037    0.148530    4.95    2019

All infants:

  0.051532    1.72    5821    0.171886    5.73    1745    0.443856   14.80     675

Children 1-2 yrs:

  0.069795    2.33    4298    0.130640    4.35    2296    0.398645   13.29     752

Children 3-5 yrs:

  0.061237    2.04    4899    0.105852    3.53    2834    0.282269    9.41    1062

Children 6-12 yrs:

  0.044523    1.48    6738    0.070793    2.36    4237    0.138508    4.62    2165

Youth 13-19 yrs:

  0.034005    1.13    8822    0.064552    2.15    4647    0.094356    3.15    3179

Adults 20-49 yrs:

  0.037480    1.25    8004    0.069503    2.32    4316    0.120463    4.02    2490

Adults 50+ yrs:

  0.039747    1.32    7547    0.071660    2.39    4186    0.127574    4.25    2351

Females 13-49 yrs:

  0.039211   78.42    7650    0.072519  145.04    4136    0.141749  283.50    2116

Attachment 6.  Pyraclostrobin Chronic Dietary Analysis Input File – Food Only

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for PYRACLOSTROBIN                     1994-98 data

Residue file: C:\Documents and Settings\lcheng\My Documents\DEEM FCID lc\Pyraclostrobin\Tol+ave062107.R98

                                                           Adjust. #2 NOT used

Analysis Date 06-21-2007             Residue file dated: 06-21-2007/10:34:58/8

Reference dose (RfD) = 0.034 mg/kg bw/day

Comment:06-21-07:Tol+ave res (apple, grape, leaf lettuce, head lettuce, celery, spinach, orange, pepper, tomato) Belgian endive 11 ppm

------------------------------------------------------------------------ --------

Food Crop                                       Residue       Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)

                                                             #1         #2

-------- ---- -------------------------------   ---------- ------     ------   -------

14000030 14   Almond                             0.040000   1.000      1.000

14000040 14   Almond, oil                        0.040000   1.000      1.000

04010050 4A   Amaranth, leafy                   11.770000   1.000      1.000

11000070 11   Apple, fruit with peel             0.310000   1.000      1.000

11000080 11   Apple, peeled fruit                0.310000   1.000      1.000

11000081 11   Apple, peeled fruit-babyfood       0.310000   1.000      1.000

11000090 11   Apple, dried                       0.310000   8.000      1.000

11000091 11   Apple, dried-babyfood              0.310000   8.000      1.000

11000100 11   Apple, juice                       0.310000   0.200      1.000

11000101 11   Apple, juice-babyfood              0.310000   0.200      1.000

11000110 11   Apple, sauce                       0.310000   1.000      1.000

11000111 11   Apple, sauce-babyfood              0.310000   1.000      1.000

12000120 12   Apricot                            0.900000   1.000      1.000

12000121 12   Apricot-babyfood                   0.900000   1.000      1.000

12000130 12   Apricot, dried                     0.900000   6.000      1.000

12000140 12   Apricot, juice                     0.900000   1.000      1.000

12000141 12   Apricot, juice-babyfood            0.900000   1.000      1.000

01030150 1CD  Arrowroot, flour                   0.040000   1.000      1.000

01030170 1CD  Artichoke, Jerusalem               0.040000   1.000      1.000

04010180 4A   Arugula                           11.770000   1.000      1.000

09020210 9B   Balsam pear                        0.500000   1.000      1.000

95000230 O    Banana                             0.040000   1.000      1.000

95000231 O    Banana-babyfood                    0.040000   1.000      1.000

95000240 O    Banana, dried                      0.040000   3.900      1.000

95000241 O    Banana, dried-babyfood             0.040000   3.900      1.000

15000250 15   Barley, pearled barley             0.400000   1.000      1.000

15000251 15   Barley, pearled barley-babyfood    0.400000   1.000      1.000

15000260 15   Barley, flour                      0.400000   1.000      1.000

15000261 15   Barley, flour-babyfood             0.400000   1.000      1.000

15000270 15   Barley, bran                       0.400000   1.000      1.000

06030300 6C   Bean, black, seed                  0.500000   1.000      1.000

06020310 6B   Bean, broad, succulent             0.500000   1.000      1.000

06030320 6C   Bean, broad, seed                  0.500000   1.000      1.000

06020330 6B   Bean, cowpea, succulent            0.500000   1.000      1.000

06030340 6C   Bean, cowpea, seed                 0.500000   1.000      1.000

06030350 6C   Bean,  great northern, seed        0.500000   1.000      1.000

06030360 6C   Bean, kidney, seed                 0.500000   1.000      1.000

06020370 6B   Bean, lima, succulent              0.500000   1.000      1.000

06030380 6C   Bean, lima, seed                   0.500000   1.000      1.000

06030390 6C   Bean, mung, seed                   0.500000   1.000      1.000

06030400 6C   Bean, navy, seed                   0.500000   1.000      1.000

06030410 6C   Bean, pink, seed                   0.500000   1.000      1.000

06030420 6C   Bean, pinto, seed                  0.500000   1.000      1.000

06010430 6A   Bean, snap, succulent              0.500000   1.000      1.000

06010431 6A   Bean, snap, succulent-babyfood     0.500000   1.000      1.000

21000440 M    Beef, meat                         0.100000   1.000      1.000

21000441 M    Beef, meat-babyfood                0.100000   1.000      1.000

21000450 M    Beef, meat, dried                  0.100000   1.920      1.000

21000460 M    Beef, meat byproducts              0.200000   1.000      1.000

21000461 M    Beef, meat byproducts-babyfood     0.200000   1.000      1.000

21000470 M    Beef, fat                          0.100000   1.000      1.000

21000471 M    Beef,fat-babyfood                  0.100000   1.000      1.000

21000480 M    Beef, kidney                       0.200000   1.000      1.000

21000490 M    Beef, liver                        1.500000   1.000      1.000

21000491 M    Beef, liver-babyfood               1.500000   1.000      1.000

01010500 1AB  Beet, garden, roots                0.400000   1.000      1.000

01010501 1AB  Beet, garden, roots-babyfood       0.400000   1.000      1.000

02000510 2    Beet, garden, tops                16.000000   1.000      1.000

01010520 1A   Beet, sugar                        0.200000   1.000      1.000

01010521 1A   Beet, sugar-babyfood               0.200000   1.000      1.000

01010530 1A   Beet, sugar, molasses              0.200000   1.000      1.000

01010531 1A   Beet, sugar, molasses-babyfood     0.200000   1.000      1.000

95000540 O    Belgium endive                    11.000000   1.000      1.000

13010550 13A  Blackberry                         4.000000   1.000      1.000

13010560 13A  Blackberry, juice                  4.000000   1.000      1.000

13010561 13A  Blackberry, juice-babyfood         4.000000   1.000      1.000

13020570 13B  Blueberry                          4.000000   1.000      1.000

13020571 13B  Blueberry-babyfood                 4.000000   1.000      1.000

13010580 13A  Boysenberry                        4.000000   1.000      1.000

14000590 14   Brazil nut                         0.040000   1.000      1.000

05010610 5A   Broccoli                           5.000000   1.000      1.000

05010611 5A   Broccoli-babyfood                  5.000000   1.000      1.000

05010620 5A   Broccoli, Chinese                  5.000000   1.000      1.000

05020630 5B   Broccoli raab                     16.000000   1.000      1.000

05010640 5A   Brussels sprouts                   5.000000   1.000      1.000

01010670 1AB  Burdock                            0.400000   1.000      1.000

14000680 14   Butternut                          0.040000   1.000      1.000

05010690 5A   Cabbage                            5.000000   1.000      1.000

05020700 5B   Cabbage, Chinese, bok choy        16.000000   1.000      1.000

05010710 5A   Cabbage, Chinese, napa             5.000000   1.000      1.000

05010720 5A   Cabbage, Chinese, mustard          5.000000   1.000      1.000

09010750 9A   Cantaloupe                         0.500000   1.000      1.000

04020760 4B   Cardoon                           11.770000   1.000      1.000

01010780 1AB  Carrot                             0.400000   1.000      1.000

01010781 1AB  Carrot-babyfood                    0.400000   1.000      1.000

01010790 1AB  Carrot, juice                      0.400000   1.000      1.000

09010800 9A   Casaba                             0.500000   1.000      1.000

14000810 14   Cashew                             0.040000   1.000      1.000

01030820 1CD  Cassava                            0.040000   1.000      1.000

01030821 1CD  Cassava-babyfood                   0.040000   1.000      1.000

05010830 5A   Cauliflower                        5.000000   1.000      1.000

01010840 1AB  Celeriac                           0.400000   1.000      1.000

04020850 4B   Celery                             5.020000   1.000      1.000

04020851 4B   Celery-babyfood                    5.020000   1.000      1.000

04020860 4B   Celery, juice                      5.020000   1.000      1.000

04020870 4B   Celtuce                            5.020000   1.000      1.000

09020880 9B   Chayote, fruit                     0.500000   1.000      1.000

12000900 12   Cherry                             0.900000   1.000      1.000

12000901 12   Cherry-babyfood                    0.900000   1.000      1.000

12000910 12   Cherry, juice                      0.900000   1.500      1.000

12000911 12   Cherry, juice-babyfood             0.900000   1.500      1.000

14000920 14   Chestnut                           0.040000   1.000      1.000

06030980 6C   Chickpea, seed                     0.340000   1.000      1.000

06030981 6C   Chickpea, seed-babyfood            0.340000   1.000      1.000

06030990 6C   Chickpea, flour                    0.340000   1.000      1.000

01011000 1AB  Chicory, roots                     0.400000   1.000      1.000

02001010 2    Chicory, tops                     16.000000   1.000      1.000

09021020 9B   Chinese waxgourd                   0.500000   1.000      1.000

04011040 4A   Chrysanthemum, garland            11.770000   1.000      1.000

10001060 10   Citrus citron                      2.000000   1.000      1.000

10001070 10   Citrus hybrids                     2.000000   1.000      1.000

10001080 10   Citrus, oil                        9.000000   1.000      1.000

05021170 5B   Collards                          16.000000   1.000      1.000

15001200 15   Corn, field, flour                 0.100000   1.000      1.000

15001201 15   Corn, field, flour-babyfood        0.100000   1.000      1.000

15001210 15   Corn, field, meal                  0.100000   1.000      1.000

15001211 15   Corn, field, meal-babyfood         0.100000   1.000      1.000

15001220 15   Corn, field, bran                  0.100000   1.000      1.000

15001230 15   Corn, field, starch                0.100000   1.000      1.000

15001231 15   Corn, field, starch-babyfood       0.100000   1.000      1.000

15001250 15   Corn, field, oil                   0.300000   1.000      1.000

15001251 15   Corn, field, oil-babyfood          0.300000   1.000      1.000

15001260 15   Corn, pop                          0.100000   1.000      1.000

15001270 15   Corn, sweet                        0.040000   1.000      1.000

15001271 15   Corn, sweet-babyfood               0.040000   1.000      1.000

95001280 O    Cottonseed, oil                    0.300000   0.300      1.000

95001281 O    Cottonseed, oil-babyfood           0.300000   0.300      1.000

11001290 11   Crabapple                          1.500000   1.000      1.000

04011330 4A   Cress, garden                     11.770000   1.000      1.000

04011340 4A   Cress, upland                     11.770000   1.000      1.000

09021350 9B   Cucumber                           0.500000   1.000      1.000

13021360 13B  Currant                            4.000000   1.000      1.000

13021370 13B  Currant, dried                     4.000000   1.000      1.000

04011380 4A   Dandelion, leaves                 11.770000   1.000      1.000

01031390 1CD  Dasheen, corm                      0.040000   1.000      1.000

02001400 2    Dasheen, leaves                   16.000000   1.000      1.000

13011420 13A  Dewberry                           4.000000   1.000      1.000

08001480 8    Eggplant                           1.400000   1.000      1.000

13021490 13B  Elderberry                         4.000000   1.000      1.000

04011500 4A   Endive                            11.770000   1.000      1.000

04021520 4B   Fennel, Florence                   5.020000   1.000      1.000

14001550 14   Filbert                            0.040000   1.000      1.000

03001640 3    Garlic                             0.900000   1.000      1.000

03001650 3    Garlic, dried                      0.900000   1.000      1.000

03001651 3    Garlic, dried-babyfood             0.900000   1.000      1.000

01031660 1CD  Ginger                             0.040000   1.000      1.000

01031670 1CD  Ginger, dried                      0.040000   1.000      1.000

01011680 1AB  Ginseng, dried                     0.400000   1.000      1.000

23001690 M    Goat, meat                         0.100000   1.000      1.000

23001710 M    Goat, fat                          0.100000   1.000      1.000

13021740 13B  Gooseberry                         4.000000   1.000      1.000

95001750 O    Grape                              0.768000   1.000      1.000

95001760 O    Grape, juice                       0.768000   0.010      1.000

95001761 O    Grape, juice-babyfood              0.768000   0.010      1.000

95001770 O    Grape, leaves                      0.768000   1.000      1.000

95001780 O    Grape, raisin                      7.000000   1.000      1.000

95001790 O    Grape, wine and sherry             2.000000   1.000      1.000

10001800 10   Grapefruit                         2.000000   1.000      1.000

10001810 10   Grapefruit, juice                  2.000000   1.000      1.000

06031820 6C   Guar, seed                         0.500000   1.000      1.000

06031821 6C   Guar, seed-babyfood                0.500000   1.000      1.000

09011870 9A   Honeydew melon                     0.500000   1.000      1.000

95001880 O    Hop                               23.000000   1.000      1.000

01011900 1AB  Horseradish                        0.400000   1.000      1.000

13021910 13B  Huckleberry                        4.000000   1.000      1.000

05021940 5B   Kale                              16.000000   1.000      1.000

05011960 5A   Kohlrabi                           5.000000   1.000      1.000

10001970 10   Kumquat                            2.000000   1.000      1.000

03001980 3    Leek                               0.900000   1.000      1.000

10001990 10   Lemon                              2.000000   1.000      1.000

10002000 10   Lemon, juice                       2.000000   0.020      1.000

10002001 10   Lemon, juice-babyfood              2.000000   0.020      1.000

10002010 10   Lemon, peel                        2.000000   1.000      1.000

06032030 6C   Lentil, seed                       0.500000   1.000      1.000

04012040 4A   Lettuce, head                      0.590000   1.000      1.000

04012050 4A   Lettuce, leaf                      7.680000   1.000      1.000

10002060 10   Lime                               2.000000   1.000      1.000

10002070 10   Lime, juice                        2.000000   0.020      1.000

10002071 10   Lime, juice-babyfood               2.000000   0.020      1.000

13012080 13A  Loganberry                         4.000000   1.000      1.000

11002100 11   Loquat                             1.500000   1.000      1.000

14002130 14   Macadamia nut                      0.040000   1.000      1.000

95002150 O    Mango                              0.100000   1.000      1.000

95002151 O    Mango-babyfood                     0.100000   1.000      1.000

95002160 O    Mango, dried                       0.100000   1.000      1.000

95002170 O    Mango, juice                       0.100000   1.000      1.000

95002171 O    Mango, juice-babyfood              0.100000   1.000      1.000

27002220 D    Milk, fat                          0.100000   1.000      1.000

27002221 D    Milk, fat - baby food/infant for   0.100000   1.000      1.000

27012230 D    Milk, nonfat solids                0.100000   1.000      1.000

27012231 D    Milk, nonfat solids-baby food/in   0.100000   1.000      1.000

27022240 D    Milk, water                        0.100000   1.000      1.000

27022241 D    Milk, water-babyfood/infant form   0.100000   1.000      1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.100000   1.000      1.000

05022290 5B   Mustard greens                    16.000000   1.000      1.000

12002300 12   Nectarine                          0.900000   1.000      1.000

08002340 8    Okra                               1.400000   1.000      1.000

03002370 3    Onion, dry bulb                    0.900000   1.000      1.000

03002371 3    Onion, dry bulb-babyfood           0.900000   1.000      1.000

03002380 3    Onion, dry bulb, dried             0.900000   9.000      1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.900000   9.000      1.000

03002390 3    Onion, green                       0.900000   1.000      1.000

10002400 10   Orange                             0.300000   1.000      1.000

10002410 10   Orange, juice                      0.300000   0.020      1.000

10002411 10   Orange, juice-babyfood             0.300000   0.020      1.000

10002420 10   Orange, peel                       0.300000   1.000      1.000

95002450 O    Papaya                             0.100000   1.000      1.000

95002451 O    Papaya-babyfood                    0.100000   1.000      1.000

95002460 O    Papaya, dried                      0.100000   1.800      1.000

95002470 O    Papaya, juice                      0.100000   1.500      1.000

04012480 4A   Parsley, leaves                   11.770000   1.000      1.000

01012500 1AB  Parsley, turnip rooted             0.400000   1.000      1.000

01012510 1AB  Parsnip                            0.400000   1.000      1.000

01012511 1AB  Parsnip-babyfood                   0.400000   1.000      1.000

06022550 6B   Pea, succulent                     0.200000   1.000      1.000

06022551 6B   Pea, succulent-babyfood            0.200000   1.000      1.000

06032560 6C   Pea, dry                           0.500000   1.000      1.000

06032561 6C   Pea, dry-babyfood                  0.500000   1.000      1.000

06012570 6A   Pea, edible podded, succulent      0.500000   1.000      1.000

06032580 6C   Pea, pigeon, seed                  0.500000   1.000      1.000

06022590 6B   Pea, pigeon, succulent             0.200000   1.000      1.000

12002600 12   Peach                              0.900000   1.000      1.000

12002601 12   Peach-babyfood                     0.900000   1.000      1.000

12002610 12   Peach, dried                       0.900000   7.000      1.000

12002620 12   Peach, juice                       0.900000   1.000      1.000

12002621 12   Peach, juice-babyfood              0.900000   1.000      1.000

95002630 O    Peanut                             0.050000   1.000      1.000

95002640 O    Peanut, butter                     0.050000   1.890      1.000

95002650 O    Peanut, oil                        0.100000   1.900      1.000

11002660 11   Pear                               1.500000   1.000      1.000

11002661 11   Pear-babyfood                      1.500000   1.000      1.000

11002670 11   Pear, dried                        1.500000   6.250      1.000

11002680 11   Pear, juice                        1.500000   1.000      1.000

11002681 11   Pear, juice-babyfood               1.500000   1.000      1.000

14002690 14   Pecan                              0.040000   1.000      1.000

08002700 8    Pepper, bell                       0.232000   1.000      1.000

08002701 8    Pepper, bell-babyfood              0.232000   1.000      1.000

08002710 8    Pepper, bell, dried                0.232000   1.000      1.000

08002711 8    Pepper, bell, dried-babyfood       0.232000   1.000      1.000

08002720 8    Pepper, nonbell                    0.232000   1.000      1.000

08002721 8    Pepper, nonbell-babyfood           0.232000   1.000      1.000

08002730 8    Pepper, nonbell, dried             0.232000   1.000      1.000

95002750 O    Peppermint                         8.000000   1.000      1.000

95002760 O    Peppermint, oil                    8.000000   1.000      1.000

14002820 14   Pistachio                          0.700000   1.000      1.000

95002830 O    Plantain                           0.040000   1.000      1.000

95002840 O    Plantain, dried                    0.040000   3.900      1.000

12002850 12   Plum                               0.900000   1.000      1.000

12002851 12   Plum-babyfood                      0.900000   1.000      1.000

12002860 12   Plum, prune, fresh                 0.900000   1.000      1.000

12002861 12   Plum, prune, fresh-babyfood        0.900000   1.000      1.000

12002870 12   Plum, prune, dried                 0.900000   1.300      1.000

12002880 12   Plum, prune, juice                 0.900000   1.400      1.000

12002881 12   Plum, prune, juice-babyfood        0.900000   1.400      1.000

25002900 M    Pork, meat                         0.100000   1.000      1.000

25002901 M    Pork, meat-babyfood                0.100000   1.000      1.000

25002910 M    Pork, skin                         0.100000   1.000      1.000

25002920 M    Pork, meat byproducts              0.200000   1.000      1.000

25002921 M    Pork, meat byproducts-babyfood     0.200000   1.000      1.000

25002930 M    Pork, fat                          0.100000   1.000      1.000

25002931 M    Pork, fat-babyfood                 0.100000   1.000      1.000

25002940 M    Pork, kidney                       0.200000   1.000      1.000

25002950 M    Pork, liver                        1.500000   1.000      1.000

01032960 1C   Potato, chips                      0.040000   1.000      1.000

01032970 1C   Potato, dry (granules/ flakes)     0.040000   6.500      1.000

01032971 1C   Potato, dry (granules/ flakes)-b   0.040000   6.500      1.000

01032980 1C   Potato, flour                      0.040000   1.000      1.000

01032981 1C   Potato, flour-babyfood             0.040000   1.000      1.000

01032990 1C   Potato, tuber, w/peel              0.040000   1.000      1.000

01033000 1C   Potato, tuber, w/o peel            0.040000   1.000      1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.040000   1.000      1.000

10003070 10   Pummelo                            2.000000   1.000      1.000

09023080 9B   Pumpkin                            0.500000   1.000      1.000

09023090 9B   Pumpkin, seed                      0.500000   1.000      1.000

11003100 11   Quince                             1.500000   1.000      1.000

04013130 4A   Radicchio                          0.590000   1.000      1.000

01013140 1AB  Radish, roots                      0.400000   1.000      1.000

01013160 1AB  Radish, Oriental, roots            0.400000   1.000      1.000

05023180 5B   Rape greens                       16.000000   1.000      1.000

13013200 13A  Raspberry                          4.000000   1.000      1.000

13013201 13A  Raspberry-babyfood                 4.000000   1.000      1.000

13013210 13A  Raspberry, juice                   4.000000   1.000      1.000

13013211 13A  Raspberry, juice-babyfood          4.000000   1.000      1.000

04023220 4B   Rhubarb                            5.020000   1.000      1.000

01013270 1AB  Rutabaga                           0.400000   1.000      1.000

15003280 15   Rye, grain                         0.040000   1.000      1.000

01013310 1AB  Salsify, roots                     0.400000   1.000      1.000

03003380 3    Shallot                            0.900000   1.000      1.000

26003390 M    Sheep, meat                        0.100000   1.000      1.000

26003391 M    Sheep, meat-babyfood               0.100000   1.000      1.000

26003400 M    Sheep, meat byproducts             0.200000   1.000      1.000

26003410 M    Sheep, fat                         0.100000   1.000      1.000

26003411 M    Sheep, fat-babyfood                0.100000   1.000      1.000

26003420 M    Sheep, kidney                      0.200000   1.000      1.000

26003430 M    Sheep, liver                       1.500000   1.000      1.000

06003470 6    Soybean, seed                      0.040000   1.000      1.000

06003480 6    Soybean, flour                     0.040000   1.000      1.000

06003481 6    Soybean, flour-babyfood            0.040000   1.000      1.000

06003490 6    Soybean, soy milk                  0.040000   1.000      1.000

06003491 6    Soybean, soy milk-babyfood or in   0.040000   1.000      1.000

06003500 6    Soybean, oil                       0.040000   1.000      1.000

06003501 6    Soybean, oil-babyfood              0.040000   1.000      1.000

95003520 O    Spearmint                          8.000000   1.000      1.000

95003530 O    Spearmint, oil                     8.000000   1.000      1.000

04013550 4A   Spinach                           11.770000   1.000      1.000

04013551 4A   Spinach-babyfood                  11.770000   1.000      1.000

09023560 9B   Squash, summer                     0.500000   1.000      1.000

09023561 9B   Squash, summer-babyfood            0.500000   1.000      1.000

09023570 9B   Squash, winter                     0.500000   1.000      1.000

09023571 9B   Squash, winter-babyfood            0.500000   1.000      1.000

95003590 O    Strawberry                         1.200000   1.000      1.000

95003591 O    Strawberry-babyfood                1.200000   1.000      1.000

95003600 O    Strawberry, juice                  1.200000   1.000      1.000

95003601 O    Strawberry, juice-babyfood         1.200000   1.000      1.000

20003640 20   Sunflower, seed                    0.300000   1.000      1.000

20003650 20   Sunflower, oil                     0.300000   1.000      1.000

20003651 20   Sunflower, oil-babyfood            0.300000   1.000      1.000

01033660 1CD  Sweet potato                       0.040000   1.000      1.000

01033661 1CD  Sweet potato-babyfood              0.040000   1.000      1.000

04023670 4B   Swiss chard                        5.020000   1.000      1.000

10003690 10   Tangerine                          2.000000   1.000      1.000

10003700 10   Tangerine, juice                   2.000000   2.300      1.000

01033710 1CD  Tanier, corm                       0.040000   1.000      1.000

08003740 8    Tomatillo                          1.400000   1.000      1.000

08003750 8    Tomato                             0.158000   1.000      1.000

08003751 8    Tomato-babyfood                    0.158000   1.000      1.000

08003760 8    Tomato, paste                      0.158000   2.100      1.000

08003761 8    Tomato, paste-babyfood             0.158000   2.100      1.000

08003770 8    Tomato, puree                      0.158000   0.550      1.000

08003771 8    Tomato, puree-babyfood             0.158000   0.550      1.000

08003780 8    Tomato, dried                      0.158000  14.300      1.000

08003781 8    Tomato, dried-babyfood             0.158000  14.300      1.000

08003790 8    Tomato, juice                      0.158000   1.500      1.000

15003810 15   Triticale, flour                   0.200000   1.000      1.000

01033870 1CD  Turmeric                           0.040000   1.000      1.000

01013880 1AB  Turnip, roots                      0.400000   1.000      1.000

05023890 5B   Turnip, greens                    16.000000   1.000      1.000

14003910 14   Walnut                             0.040000   1.000      1.000

09013990 9A   Watermelon                         0.500000   1.000      1.000

09014000 9A   Watermelon, juice                  0.500000   1.000      1.000

15004010 15   Wheat, grain                       0.200000   1.000      1.000

15004011 15   Wheat, grain-babyfood              0.200000   1.000      1.000

15004020 15   Wheat, flour                       0.200000   0.700      1.000

15004021 15   Wheat, flour-babyfood              0.200000   0.700      1.000

15004030 15   Wheat, germ                        0.200000   0.850      1.000

15004040 15   Wheat, bran                        0.200000   1.000      1.000

01034060 1CD  Yam, true                          0.040000   1.000      1.000

01034070 1CD  Yam bean                           0.040000   1.000      1.000

Attachment 7.  Pyraclostrobin Chronic Dietary Analysis Results – Food Only

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for PYRACLOSTROBIN                   (1994-98 data)

Residue file name: C:\Documents and Settings\lcheng\My Documents\DEEM FCID lc\Pyraclostrobin\Tol+ave062107.R98

                                                 Adjustment factor #2 NOT used.

Analysis Date 06-21-2007/10:38:58     Residue file dated: 06-21-2007/10:34:58/8

Reference dose (RfD, Chronic) = .034 mg/kg bw/day

COMMENT 1: 06-21-07:Tol+ave res (apple, grape, leaf lettuce, head lettuce, celery, spinach, orange, pepper, tomato) Belgian endive 11 ppm

======================================================================== =======

                    Total exposure by population subgroup

------------------------------------------------------------------------ -------

                                                    Total Exposure

                                         -----------------------------------

          Population                         mg/kg             Percent of

           Subgroup                       body wt/day             Rfd

--------------------------------------   -------------       ---------------

U.S. Population (total)                     0.006443                18.9%

U.S. Population (spring season)             0.006504                19.1%

U.S. Population (summer season)             0.006510                19.1%

U.S. Population (autumn season)             0.006375                18.8%

U.S. Population (winter season)             0.006382                18.8%

Northeast region                            0.006854                20.2%

Midwest region                              0.006011                17.7%

Southern region                             0.006057                17.8%

Western region                              0.007147                21.0%

Hispanics                                   0.005832                17.2%

Non-hispanic whites                         0.006152                18.1%

Non-hispanic blacks                         0.007512                22.1%

Non-hisp/non-white/non-black                0.009640                28.4%

All infants (< 1 year)                      0.009885                29.1%

Nursing infants                             0.005141                15.1%

Non-nursing infants                         0.011686                34.4%

Children 1-6  yrs                           0.012986                38.2%

Children 7-12 yrs                           0.006959                20.5%

Females 13-19 (not preg or nursing)         0.004015                11.8%

Females 20+ (not preg or nursing)           0.005884                17.3%

Females 13-50 yrs                           0.005304                15.6%

Females 13+ (preg/not nursing)              0.004332                12.7%

Females 13+ (nursing)                       0.006176                18.2%

Males 13-19 yrs                             0.004862                14.3%

Males 20+ yrs                               0.005551                16.3%

Seniors 55+                                 0.006534                19.2%

Children 1-2 yrs                            0.015951                46.9%

Children 3-5 yrs                            0.012148                35.7%

Children 6-12 yrs                           0.007357                21.6%

Youth 13-19 yrs                             0.004454                13.1%

Adults 20-49 yrs                            0.005278                15.5%

Adults 50+ yrs                              0.006476                19.0%

Females 13-49 yrs                           0.005123                15.1%

Attachment 8.  Pyraclostrobin Chronic Dietary Analysis Input File – Food & Water

U.S. Environmental Protection Agency                                 Ver. 2.00

DEEM-FCID Chronic analysis for PYRACLOSTROBIN                     1994-98 data

Residue file: C:\Documents and Settings\lcheng\My Documents\DEEM FCID lc\Pyraclostrobin\Tol+ave+water062107.R98

                                                           Adjust. #2 NOT used

Analysis Date 06-21-2007             Residue file dated: 06-21-2007/11:05:03/8

Reference dose (RfD) = 0.034 mg/kg bw/day

Comment:06-21-07:Tol+ave res + water (apple, grape, leaf lettuce, head lettuce, celery, spinach, orange, pepper, tomato) Belgian endive 11 ppm

------------------------------------------------------------------------ --------

Food Crop                                       Residue       Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)

                                                             #1         #2

-------- ---- -------------------------------   ---------- ------     ------   -------

14000030 14   Almond                             0.040000   1.000      1.000

14000040 14   Almond, oil                        0.040000   1.000      1.000