Okay, three people, about one more minute, so if there's questions from the room during, I'll ask you to repeat them back because some people on Zoom won't be able to hear otherwise, so they might be able to hear.  Okay, well, we'll go ahead and get started. So, really great to have, I'm kind of proud of this dog out here from Simulations Plus and what I understand, he gave a really great talk at the Comchem, or the computer discovery GRC this summer on working with chemical data, which is something that I've done a lot of and probably not as much as him and I've suffered a lot in doing and so I'm really excited about learning from him on this and hearing about it and it's also very relevant to work at the open force field initiative is doing and I know work that we're doing in the lab as well. So, this is also an open force field webinar, so we have an audience on Zoom who may ask questions if you're on Zoom and you want to ask a question, you can certainly just shout at it or we'll call on you at the end and also if you're trying to interrupt during, you're welcome to try to drop things in the chat window and try to keep an eye on that and likewise, if there's problems with the audio, feel free to chime in and we are recording this so hopefully we'll be available to others later. So, please go ahead and sign down. Great. Thanks so much, David and open force field initiative, especially John and others from open force field who have thought that this could be an important talk for mostly all the people working in chemical mathematics, especially doing a model building. So, what I'll be discussing over here is the process of data curation and I specifically mentioned here that this is the forgotten practice in the era of AI because nowadays everybody is talking about AI or artificial intelligence and thinks that okay all we have to do is get the data and build the models. So, it is not a QSAR modeling or model building is not just a push button approach but it needs a lot of preprocessing of the data. So, what I mean to say here is when you need any news or if you put it as any activity data, it is necessary that you validate that data prior to using it in your model building or building and these are the two news actually which were which have been published which were which appeared in news one was about the Loch Ness monster and the other one is a Black Bigfoot in California. Now, people believed these news for big heads actually and until if you find someone who can mention that this is a fake news you won't find it. I'll get back to this these two photographs during my talk later but this is something what we have to believe when you're dealing with the activity as well. We have to find out if there is anything wrong in the data or there is any fake data. So, before I start my just before I start my talk I just want to mention that I do not want to evaluate or criticize any public or commercial databases here because these databases are definitely useful and just we cannot evaluate that these are bad data or this is good data. So, it is my my intentions are very straightforward. I just want to suggest how we can utilize these existing databases efficiently and how we can advocate if I can advocate a strategy for data curation that is what I want to discuss over here. So, just to just before I enter into just before I discuss my outline I'd like to show why data curation is necessary. So, this is the email my colleague received a few months back from one of our customers and I'd like to highlight over here it says we have some test data through Admit Predictor and we have we get rather poor correlations. Now, Admit Predictor is a software simulations plus distributes which has more than 140 Admit properties actually. So, they were evaluating it and they found that the predictor is not giving us good predictions and they shared few data sets with us. One of the data set is for human liver microsomal clearance model. So, they shared this link with us. They collected the data from Timbal and they compared they predicted the HLM clearance from Admit Predictor and looked at the prediction versus experimental value and this is the correlation they found. So, looking at this correlation they just mentioned okay we don't see a good correlation. When they shared this data with us we got this data we carried out some data curation and convergence and what we see is a very good correlation. So, what did these investigators miss? First of all if you look at the if they had looked at the predictor manual we have specifically mentioned in our manual that the HLM clearance data is corrected for microsomal binding they missed on that part. So, first thing they missed was converting the bound clearance to the unbound clearance. So, if you do that kind of conversion you have a correlation which appears on the right hand side of the screen. Secondly, you cannot complete you cannot use the data which are boundary data. Like for example there were 84 compounds which have been mentioned as greater than 150 or there were more than 250 compounds which were mentioned as less than 3. You cannot use those data points when you are comparing the predictions. So, if you remove those if you carry out appropriate convergence and if you remove these compounds which are not relevant then yes we do see a good correlation. So, this is what is happening everybody thinks that in case of AI all you have to do is get the data run the predictions or get the data and build the models. This is the notion we want to change actually and what kind of preprocessing is required that's what actually and what we faced during our preprocessing processing is something I will be discussing over here. So, this is the outline of my graph only four points what is data validation where are these errors coming from and how do we find these errors and finally why should we care about them. This is I already discussed one example that yes we need to care about them I'll definitely show more. So, let's start with data validation. Data validation is if you look at the dictionary meaning of validation it just mentions that it is an action of checking or proving the validity of accuracy of something and if we apply the same definition towards the data validation or data curation what we are doing is it is process of ensuring data have undergone data cleansing that means the data curation what we are doing to ensure that they have the data quality that is both correct and useful and that is where actually the data curation or data cleaning comes into the picture. In drug discovery validation is an absolute necessity you cannot simply believe the data specifically if you are extracting it from the big databases you cannot simply believe those data actually on an average it has been shown that there are at least two errors in each medicinal chemistry paper this is an I'm just mentioning the average error that could be more there are papers which are absolutely perfect in terms of chemistry and biological data and overall error rate can be as high as 8%. These errors I'm not talking about the systemic errors or random errors that is a different topic I'm talking about the errors in the databases which can be introduced during the data digitization or data extraction from the papers and if we want to build the accurate and predictive models the clean data and the accurate data is absolutely necessary and it is my data so if we see the databases which are available for bi-activity the chemical databases or the bi-activity databases there are tons of databases of the collection I wouldn't say tons of but tens of databases so we have Campbell or Pugging or BindingDB these are the free ones but there are commercial databases like Ghostar database or Deceptive Database or Clarify database so these are the ones which are commercial databases as well so the usefulness of these public data sources is questionable actually because of the quality control which is lacking when these databases are built so once we have the data extracted the data we cannot use it we have to wash the data we have to rinse the data and sometimes we have to scrub it and this is what is necessary before model building actually before using the data for any purpose so what I will be discussing here is simple my if there were no there are few papers you have discussed about these data curations so what I'm discussing here is only my experiences only after sharing or after knowing what people have been doing so what I'm showing here is I have my experiences after standing on the shoulder of the giants so who are these giants if we look at them there are a few papers from there are a few papers in the literature which is like Trust by Verify by Professor Grop or there are two from Tony Williams Loop these are the data which are talking about chemical structure curation so if you read these papers most of these papers are talking about oh you have to standardize the data you have to carry out neutralization you have to use appropriate automers you have to use desalting you have to take check check them if the compounds are mixtures or take care of the stereochemistry so most of these papers do talk about chemical structure curation or chemical structure standardization but there are few papers which are talking about bioactivity apart from the chemical structures so these are recent papers which are mostly talking about the biological data and but these people do not mention how these data curation what are the troubles in data curation or how do we find this and this is what I will be talking about in this talk that where do we get these errors from okay we have these databases where do we get the errors so there are various sources of errors I'll just start with simple data extraction so as I mentioned I do not want to bad mark any database or any authored section so what I'm showing is simply the compound identifiers as compound x or compound y without showing the actual database id or compound names so if we look at this data from one database what we extracted the same compound has two different ic50 values one is 56,000 nanomolar and one is 56 nanomolar now if you go back to the references of these paper this is just a reference in terms of Kimbell reference actually just if anybody is interested in this is a terfinadine and one author mentions that terfinadine herga ic50 is 56 nanomolar and the other author mentions that terfinadine ic50 is again 56 nanomolar so when the data extractor database extractor whoever extracted this data he made a mistake in terms of instead of saying 56 nanomolar he mentioned it as 56 micromolar and that made a huge difference if you just get this data and predict herga ic50 using any commercial model you will see that okay one compound is predicted very well the other compound is predicted by t-login and difference and then people start comparing oh that model is not good the commercial model is bad so we have to be very careful when you're extracting the data second source of extraction is source of data error is again data extraction now what i'm showing here is an example from commercial database here this is a discipline and bioblability of discipline is 0.15 if we look at this it says activity is 0.15 which is a bioblability so that means bioblability is 0.15 this looks quite realistic why because the range of traction bioblability on bioblability is 0 to 1 so if i tell you that bioblability is 0.15 people can believe it but unless if you look at it as enzyme cell assay now enzyme cell assay says that it is a fraction of compound unbound in human plasma it is not a bioblability what they are discussing is plasma protein binding and unfortunately or fortunately the range of fraction bound is 0 to 1 as well so until you look into these databases and begin more what exactly these activity or these values are representing you cannot you should not be trusting the numbers as is this is the classic example where the fu value or the 0.15 could be fraction and bound or bioblability but when you look at the assay then you find out oh it is a protein binding not bioblability so these kind of errors need to be taken care of need to be looked at actually when you are looking at the data now there are some sources of errors which are original research articles what i'm showing here is the same author Singh Adam published identical compound which is am 8191 in two different papers one is in 2014 and one is in 2015 in one paper they mentioned that guys and in the second paper they mentioned that it is her guys 50 is 18 nano more so again in this case the database guys database extractor they did not make any mistake they pulled out the numbers what they see in the paper but when you see these kind of differences specifically three log unit differences or six log unique differences it should immediately click to you that there is something wrong with these numbers because the significant numbers are identical what you are looking at is just the micro molar or nano molar numbers so we have to be very careful when you are looking at 18 nano molar or 18 micro when we built the model for her guys our model suggests that her guys is 50 value of this compound should be 18 nano molar and not 18 micro another source of error is us us means the database use so what happens is many times some these programs are designed in such a way that when you read the smiles or sd files and it has the extra salts or counter ions associated with those compounds it is available as a single smiles rotation for a single compound but when these programs like even admin predictor or other programs when they read these software when they read these miles or sd files they look at it in terms of oh this is extra salt or solvent and it needs to be split it out so they are designed to help the users to take care of the counter ions or the salts but at the same time user needs to be very careful when you're looking at these uh these salts duplicates for example if you look at these compound this compound is by chemical structure it is duplicate and the LD 50 for these two compounds one is 810 mixbuff eggs and one is 150 mixbuff eggs but what we miss here is in one case it is a citrate salt and in one case it is a pure compound so we cannot compare one cannot necessarily compare the activities or toxicities of different salts you have to be careful when you're comparing or looking at the duplicates and you'll see oh there are duplicates with different numbers they have the wrong data or there is something wrong with it it is not you are ignoring the salts or the solvents sometimes these numbers are pretty much similar so if i see these compounds we see there is no hardly some difference like 290 versus 350 of the difference but when you are looking at some phosphate salt and a regular one there is almost tenfold of difference or ninefold of difference you have to be very careful when you are comparing the duplicates and just you cannot come to a conclusion that they are identical compounds and having different numbers so we are equally responsible we cannot just blame the data with data extractor or the authors we are equally responsible for looking at the data and last but not least is a i call it abcd which is automated and blind compilation of data now this is something actually we are facing it a lot nowadays so it is very tempting to automate the conversion itself so there are programs which just look at the pdf file and extract the compounds and store it as smiles or sd file so this is a very good example what we found is this compound 21 shows extracellular double bond in the original research article so this is the geometry paper we are talking about when we built a model now this is this data was extracted for rag plasma protein binding data when we built the model this compound always jumped out as an outlier even if we include it in the training set the final prediction was always very long so we it we started thinking what is going on in here most of the times if you talk to curious here people they say oh this compound is always an outlier we have to throw it out or we should not use that but instead of that if we can go back to the original paper and see what is going on then you can find this compound is reported in the paper as as you can see there is a double bond over here so what this compound the lower chemical structure has hidden the carbonyl oxygen which is missing when we corrected this chemical structure and added back to the database then voila our database this compound was predicted perfectly fine so this is what we call it as an abcd mostly you cannot just there is there are advantages of automation no doubt about it it helps a lot to pass in the process but just be careful when you are looking at the data because of the these automation there is a possibility you're missing one something and you have you may ignore that compound just because oh this is a wrong compound this is another example of abcd this is not really clear but the this the compound what we are looking at is over here number 15 which has r3 as f the r3 group is over here the pin this substitution is f and the r1 r2 is i think that is the prizine of the prizine chain with fluorine but if you look at the compound 15 and compound 16 what the extractor has done is they have combined r1 r2 r3 group of 16 over here and fluorine group of r3 group of 15 over here so these kind of mistakes are very common when we are looking at automated program which extracts the data so we need to be very careful about this kind of abcd let's find out how let's see how we can find them actually this is what i'll be i have few ideas that what we are using when we are extracting when we extract the data and how do you find it first of all just look at the activity clips or technoscopic clips for example this is the data which is available from i think epa or epa dashboard it is a ld50 data at ld50 data which is available in milligrams per clip now i tried to look on specific outcomes have used to be very unusual because all other compounds have very low toxicity very high toxicity low number means high toxicity and this compound doesn't so the reference of this paper is very old it is a 1984 paper so till now nobody has gone back to those paper we don't know if that paper is available or not in the pdf format but we somehow managed to get this paper and the compound number 89 which is shown over here it corresponds to 0.322 milligram per kilogram that means they have missed on the decimal point right before the entire number and that's why actually you can see a huge activity atoxicity clip when you're looking at this when you're looking at this similar example i have is from other set of compounds which are you can see that ld50 is almost 7000 milligrams 7 gram but if you look at 11 most similar structure of this compound they are all against single digit numbers of course in this case we do not have the original reference we couldn't get the original reference but when we build the model we remove this compound put it in the test set just for our understanding what is going on we build the model of ld50 and find out that if we predict the toxicity of this compound it comes in the range of 6 to 12 that means they have also missed on one decimal point maybe up to 7 over here and so if you have a data just look at it in terms of activity clips or toxicity clips many times you can immediately point out this compound that's something there is something wrong with this compound or there's something wrong biological activity or toxicity of this compound that's how actually you can easily find out if there is anything anything wrongly reported or wrongly extracted you can also run some molecular match pair analysis for example in this is the data from our rat plasma protein binding data and you can see that most of the match pair most of the transformations here are nitrogen to carbon specimens replacements or substitutions but the difference between the rat plasma binding in in these cases is not very significant but specifically if you look at the first pair the difference between rat FUP of these two compounds is very significant so that triggers us an idea okay we have to go back to the origin okay look at it for this one so there if we can use various cheminformatics tools like toxicity clips or flustering or map molecular match pair analysis to find out if there is an the data is consistent or there are if there is an inconsistency in the data this is one approach we use a lot nowadays actually if we have hundreds and thousands of compounds what we do is leave one group completely out to build a model and see how that group is predicted using our the temporary or intermediate model and what we see here is now this is an example we found that the units were reported in the database as microliter per milligram of course and when we built a model for without these groups and then we found that these group these compounds are not predicted well back to the original paper we found that the actual units in the paper are milliliters per minute per gram of liver so whoever works in clearance model building they know that these two convergence need almost 50 there are some factors actually which are required to make this convergence and those convergers were missing when the extractor data this extractor or data extractor extracted the data and it is very easy when you build the models without with just like by leave one leave group out instead of leave one out or leave by out this kind of a cross validation for us as well similarly in this case what we noticed is there were a few set of compounds which were reported there were unit discrepancies by so our models predicted that our most of the compounds were over here but there are a few sets of compounds which we found that they were predicted very low when we looked at the paper and corrected the numbers this is what we find that all the compounds have moved into the cluster and these compounds have moved so what we have found is if they're if by using leave group out if we see the difference of three log units or six of unit differences then there is definitely the data extractor has messed up with the units like instead of micro molar here put it in micro molar to nano molar or micro molar so that kind of errors are very common in the database now this is another example actually when we are building a model for qcr everybody thinks that we should have a wider range of ic50 values or pic50 values so what we see here is the data extractor did not they just mentioned that okay this is pec50 value but pec50 value needs a specific conversion that is a minus log n to the that kind of conversion was missing why because pec50 value cannot be 0.078 pec50 values most of these pic50 values or pec50 values they are in the range of two to ten or three to ten but less than one is definitely something which whoever is building a model should immediately ring a bell over there that 0.078 doesn't seem to be the pec50 value but similarly pec50 value of 36 means is ic50 value is in molar or even tens of molar that is not actually right number so basically we have to be careful when we are looking at few data points which are way out of the normal ranges so when you're building the model you should be aware what are the normal ranges of these set of components of these properties so we have to be careful as I said actually we are equally responsible for data creation then we cannot just blame the data extractors now this is another example I was building a model for ratio of blur to plasma and most of the names the range is again 0.55 maximum up to 1.5 or 2 I had these almost 300 data points when I plotted them against our predicted human rbp value we noticed that the experimental rbp value there are 35 compounds having experimental rbp value of 1 and there are almost 22 compounds having experimental value of 0.55 origin we go back to the so if you look at the chemical structures one is nalaxone one is nalaxifin they are pretty different chemical structures but yet they have rbp value of 1 similarly if you see indomethacin and others over here they are diverse chemotypes but again you see 0.55 so that doesn't look that doesn't sound good actually it is we need to see what exactly is going on so I went back to the original papers and what we see here is actually disturbing because many authors they just mentioned that okay no data available value of 1 assumed for desinders and people who have built these models in the past they ignored it they just looked at it okay rb value is 1 let's use this value in building the new summer now say same thing over here like it says 1 for basic and 0.55 for acidic drugs okay now something that is more funny is this author it says assume to be 0.55 and he has a reference of this paper which is qubit at all so somebody has used it that's why I'm using these assumptions that is something which is disturbing and more importantly the people who are building the q-sol models using these kind of value I really feel bad that people do not even care to look at those footnotes when there are specific numbers if it rings a bell look at the footnotes in those papers there is something you will find but finally we just removed those compounds from our analysis and built a model and then we found that okay yes that was good the last example last but not the least actually user experience it is very important when somebody is building a model his experience counts are not the example what I'm showing here is provided by my colleague Bob Clark he was working with building classification model or metabolism model for ester hydrolysis so he looked at some compounds from the WDR world drug index and this is the drug oh I have it I did not have it oh yes it is a proximal orange so and it is available as pro drugs in the WDR as well so mostly when when he carried out the ester hydrolysis of these pro drugs he came across that in one case it was even numbered carbon chain and in other case okay in this case it was even number carbon chain in this case it was odd number carbon chain which is very unusual because mammals have problems metabolizing the odd carbon long chain so most of the pro drugs which are built in they are with the even number carbon chain and when he looked at it it is odd carbon odd number carbon long chain then he went back to the chemical structures so if we look at this chemical structure and it's ester it should be COO instead of having O C O actually this is a reverse hydro so the even the world drug index database they had messed up with these infrastructure when they added the data and if I was building these models I would have never picked it up because I did not know about these problems related to metabolizing odd carbon or even carbon so yes user experience it has come a lot when we were doing the data creation lastly I just want to discuss why we should care about these data creation so I'm going back to the original structural pictures which I showed you that these are the two main news which which had been in everybody believed him in dick for decade but it's the fact that if the lie is repeated a thousand times it becomes a truth so in 1993 the original photographer of that lockness monster he admitted that he had made this monster out of some plastic and some clockwork and some toys a million that means the picture what appeared in 1934 it was a lie it was a fake photo similarly if you look at the big foot news in 1950 it had been in the it had been there for in what since 40s or 50s until the original photographer's family revealed a secret saying that the whole thing was a hoax Wallace had made the oversized footprints with a set of carved wooden feet and so what happens is if these people had not revealed it we would have never found out that these are the fake news but what happened in between is these news have become so much of a truth these are the news in 2017 people have still been going over there to find out the lockness monster so it is a record year for citing the lockness most of people still believe there is most over there or people still believe there is a big sight for you so you and once it has been in the news or once it has been there or so many decades people don't believe that it's a lie it just becomes true and this is what actually we fear a lot in terms of chemistry as well let's look at the example now amiodarone and amiodarone hydrochloride so amiodarone is a simple so what we are looking at is amiodarone structure solubility of amiodarone is shown to be 700 milligrams per meter and this these are the snapshots of the game data section and the literature the back reference is marked next which we believe that it is an official record and if we look at its salt again we see that it's salt the solubility of salt is 700 mixed per meter as well and again the same reference page but if we notice actually everybody who works with chemistry he knows that the solubility of the plain molecule and its hydrochloride salt or in salt it cannot be added when my colleague Bob Clark was building the solubility models for our using admit modeler the program consistently found it as an outlier so its nominal solubility of 0.7 nix per ml or 700 nix per liter is true we found that this is less actually the it is predicted to be less actually compared to what the report said because we build a model only on plain molecules not with hydrochloride salt so unless we go back if we build the model and we find out that this is an outlier we could have never found out that there is something this comes in these two structures and these are actually an official records in murph index is an official record another example which my other colleague Marvin Waldman found out is about the fantasy many of you may know or many of you not know actually this compound is a non-existent compound this compound doesn't exist okay but it got well it got into the literature for computational work trying to rationalize the fact that it doesn't exist so they just designed a compound carried out some computational studies showed that it does not exist even then it has a cast number and surprisingly it is available on the pubca if you go to pubca inside it is available by the chemical vendors there are few chemical vendors they are ready to sell this non-existing compound now what happens is once that happened this becomes a virtually real compound and somebody will ask so what is how is it going to matter now how it is going to matter in terms of drug design here is something if you just follow these biostatic replacements so diazepam and bromazepam they're a simple biostatic biostatic replacement and how it is in terms of ai people just ignore to look at the chemical structures and just go on building the models designing the virtual library of compounds hundreds of thousands of compound library so i won't be surprised down the line someone designs compound wherein they have replaced the panel ring with this pentazine ring because this exists in pubca but this is you can buy it so why not design it so we have to be very careful actually when we are looking at these kind of data and whoever is using this actually i'm afraid down the line people will start using these even if it is non-existing compound they will start designing the compounds using these fragments and i did not mention actually the pubca website itself mentions that it is a hypothetical compound and another example actually which is my favorite this is another example from pubca so this is a chemical compound which is part of the pubcum database it has a molecular weight molecular formula and the reference reference is United States patent this compound is extracted from the patent and the patent reads lip polyamines and preparations and uses there so if you look at lip polyamine structures these are the structures which are lip polyamine structures so there is nothing wrong with these structures they are all the so this patent includes all the lipopolyamines and the substances or the raw materials that are used to synthesize them so where does this big compound come from the only graphics that looks very similar to this existing compound is a bar chart depicting comparison of transfection efficiencies now what happens is how did i come how did i why do i think that it is the same compound and let's look at it it has 19 carbon it is 19 by 11 grid and we have it as a 19 by 11 grid and they also have these little spikes pointed as carbons or metals so and there is no other graphic in the entire patent which will tell you that this compound is exist in this compound is from that pattern i this is i'm saying it is an assumption but i'm pretty sure this is the only graphics from which it gets and how do we get that i already mentioned about ABCS automated and blind data curation or curation of data there are programs which just look at those PDF files and if see if it sees some graphics it just translates it into the chemical structure without knowing that it is if it's a compound and it's a stop so these are the wages of automated and blind curation of data now actually something i like to mention people asked me a lot after my last presentation at GRC can we automate this process and yes we can but we have to be very careful that when you are looking at the data it is whatever i have shown you is fake data or wrong data but there are blacks ones available so yes it does it there are some news which are real for example this fossil fish news it does it is a real news you have to be very careful when you are differentiating between fake and real news and this is the example which i show actually this is the example of blacks one in terms of chemistry so i showed you activity clips before which were fake but it's not necessary that activity clips are always fake because now this compound versus these two compounds they have four points they have ic50 herb ic50 of four p ic50 in four but this compound has very high p ic50 but this is possible the reason behind that is most of the herb ic50 values are the acidic group one compound is responsible for the it affects the herb ic50 value so yes these kind of data this kind of blacks ones do exist in chemistry you have to be careful about many people asked me at Gordon Conn from many years back and that is an automated curation procedure but what authors missed here again as i showed i don't want to show the names of the authors but you can definitely go back over there and find out what authors missed here is for example in this case this is one example that the compounds lost the aromaticity when they carried out the automated curation of thousands of data thousands of compounds they ignored to look at the structures at the end if there are any discrepancies or they did not match the initial structures and final structures they lost the aromaticity or they also found that the initial structure was in iodide salt but finally the curation process just combined it just made a covalent bond between sulfur and iodine and this is not the only example actually these are not the only examples there are many examples in this curation process i have looked into my colleague Marvin has looked into these data and he found that there are many compounds which have lost their aromaticity or there are many compounds for which you can see the covalent bonds between sulfur and iodine so i understand automation is necessary but at the same time you have to be very careful when you're using the automation and you have to compare or at least do some sampling when you're doing the final structure comparison so it's what i always talk about that like when you are building a model it's up to you if you want to have an extraordinary model or if you want to have just extra and an ordinary model it all depends on how much you rate the data so you want to validate the data or not to validate the data it's completely up to you but whatever efforts you take in pre-processing or data curation it is going to make a difference in your model which is extraordinary or extraordinary so this is the conclusion which i want to mention here is watch out for the abcd's i showed few examples of abcd's actually when you are doing the data curation or data cleaning you have to watch out for those actually and we have to be very vigilant about using the bioactivity when you when we are using the bioactivity databases or the compilations we cannot simply use these just get the data and build the models it doesn't work this way many people think that qcr is just push button approach it is not actually there is a lot goes behind building the future model i also mentioned automation is necessary but it could be dangerous as i have shown you an example that you have to be careful at least do a random sampling of looking at the structures after automated curation and finally this is i have been telling everybody that if you see something say something not now maybe down the line the example which i showed about fantasy if we don't mention it to others there is a possibility that after a few years somebody will definitely come up with those kind of compounds which i showed you so it is necessary at least spread a word if we can contact the database guys of course we should tell them that this is wrong we should take it out or at least make some i would say note over there that this compound is okay has made a note that it is hypothetical compound but people do ignore it so we have to be very careful and as they say we don't plant pairs for us we plant the pairs for our hairs so we have to be vigilant and we have to mention about it so what i mentioned what i spoke about today these are not only my own examples actually the entire simulations plus cheminformatics team have been involved in doing all the data operations i'm just talking on their behalf so Bob Clark Marvin Marvin Mike Bolger Robert David and Michael along with Eric and John they have been always supportive and they have been working on the data operations along with me as well so and of course i'd like to thank the open force field initiative team who have given me a chance to speak on this topic actually for this open force field initiative thank you so much and i did not mention on the similar topics whatever i discussed about the data curation or model building we are hiring on the sea hiring for the same task actually so we have a position often for post-op thank you but i'm a question but i mean so i very much you know think what you're doing is great but i'm curious like so a lot of it kind of relies on noticing things that are obviously crazy which is which is really great for things that are obviously crazy but i wonder about the things that are not obviously crazy that are probably also wrong or at least some of them are wrong like i can tell you i saw kairi and my friends and it's not obviously crazy because sometimes i see them but i didn't actually see either so like the same thing for chemistry like you know see i'm stuck there with bad mail and so that creates huge outliers but what about things that are also wrong but they aren't wildly wrong what do we do about those how do we catch them um what are the what are the things about wrong but is there any hope for catching errors that are not as bad they're like wrong compound but it doesn't create a huge outlier um they yes i completely agree that the solutions are how to find those find the levels whatever i mentioned they won't be able to catch them off specifically if you have a compound which is very it is not very bad and it is not impacting the thing and so there if you are building a model and you're doing some clustering so most of the times it just it definitely gives you an indication of there's something not but yes we do meet that kind of compound the person kind but it is very um very rare case actually at least in our cases whatever data we are looking at we do not come across any of those kind of um yeah i think we needed ourselves for a minute apologies and um okay that's helpful yeah yes so i'm kind of new to municipal chemistry but i heard a lot about active groups and at first i thought that they were all that's kind of data herds and then later i thought oh wow these are real and people don't believe them really hard yes now i'm hearing again that maybe several of them are data herds can you since you've probably looked at a lot of these can you get some insight as to like what fraction of active groups you found are are real when you dug in and what fraction are so the question is uh what fraction of activity coefficient a clip activity clips are data errors versus real we'll take questions from jamie so um what i realized is it's most of the times if you are looking at the data from the databases you have to be careful about that so i cannot mention about the activity clip fractions because i just showed you an example which are actually are real so um and i think there have been few groups working from europe they have been working on activity clips a lot actually so but i would say with 50 50 chances that there are chances that some of the activity clips are real actually and we did come across those but if they are affecting your model a lot then you have to look at those seriously just go back to the original paper and find out if they are right but again you never know if the author has made any mistake but we should we saw the example in one of the slides that occur on some extreme state so if your model is definitely telling that this is an outlier or this is something uh suspicious data you can definitely reach out to the author of the paper just to clarify your doubts are there questions from zoom okay questions from zoom i don't think are there questions from the program yes please we do contact the authors like for example this automation paper what i show in the last we did contact the authors actually and the author has sometimes authors or the database administrators they take it positively they do accept that yes it was a mistake but one of my colleague approach is about the the big grid molecule i showed you about that kind of one thing but okay guys did not ask the thing i said okay we still want to keep them in the house they want to remove it so sometimes we have positive responses sometimes people say okay i i know they are wrong but we want to keep them there are certain we have to take them with a pinch of sauce okay sorry the question was if these errors which i have shown in the on the slides they were they have been taken care by the database people or not sorry i shouldn't have mentioned that before we have last chance for people on zoom yes well they are i don't think it's a well yeah it does have some kind of but all of them are i would say cyclobutans okay well thank you very much you really appreciate it thank you


you can hear me sorry about that guys I was I was using X I am using Xflit to record this stream and now you should be able to hear me let me know if you can so this is the George show welcome to the George show live edition and I have Anthony in my ear telling me if there's any issues with the live stream or any good questions right so I just heard myself it's about a 45-second delay so anything you ask I won't hear until you won't hear 45 seconds later hi floaty welcome to the freedom family of course you're welcome for the opportunity to get partnered with us and we'd love to see you in the comments of the George show interact with our partners on the forums and that's what this is all about we're a family and we help each other grow together so in the last few episodes of the George show we've been talking about kids and kids content so we have now a freedom kids channel and as well Avienda has her channel and we have one of our staff his name is Aaron stuck and he has a channel for his kids that is also all linked on the freedom kids hub that you can find on the main freedom channel and look right on the right side there is links to freedom kids as well as other freedom channels just reading the comments well we're trying to give you a variety of content someone was asking why so many freedom videos and we have impulse of course our professionally produced show that was also invented by Aaron stuck and he's the producer of the show we have Curtis Pike aka Big C who announced freedom online a way for all freedom partners to submit their videos for promotion on our new freedom online website and we just want to make sure we let you know everything that's going on and so that takes a lot of videos I hope I hope you enjoy the video content on Freedom Central cameras a bit too high okay let me see what I can do about that let me construct the the George show set one moment guys while we while I while I do that I can keep talking so that it's not too boring and the videos did you know that YouTube cards have been released YouTube cards are now public for everyone to use I made a video about them but back then a lot of channels didn't have access to YouTube cards but now everyone does are you using YouTube cards do you know what they are and tell me in the comments below so here's how I construct here's how I construct the George show I take these boxes they're hard drive boxes I lay them on the floor then I take three more boxes lay them on the floor then I take this monitor box aces monitor box I lay that on the hard drives to give me a little more elevation and then I take this chair put it on the monitor box adjusting the hard drives I put it wrong way there we go and then I take this second monitor box use it to bring the microphone closer to me as well as my keyboard and mouse which is right here game deus keyboard and game deus mouse and once I have all that then I sit on this chair as well as I turn on an extra light I'll need to get my headset voila that's the George show actually I don't have a personal assistant yet but I would like to get one because I miss a lot of emails and many don't get even replied so yes that's my plan but I have yet to find someone who could do that well the main difference is that TGN was branded as a gaming network and freedom from the beginning is branded as an everything network it's more of a concept and so if you just compare MGM with TGN the main difference is that MGM is focusing on original content we have some amazing League of Legends and World of Warcraft videos that are written by Ben French and acted on by professionals and those get about 10,000 views per video you can check them out at youtube.com slash MGM we see a lot of the things though are the same like we have now a World of Warcraft guild called MGM wow we also have a YouTube channel youtube.com slash MGM wow and that's the same as TGN World of Warcraft was back in the day so there's a lot more similarities than there are differences well we have a professional studio in construction right now in fact that was yesterday's video on freedom central if you haven't seen it go to youtube.com slash freedom and click the videos tab you can see the latest episode of the George show which was talking about freedom studios construction so that's that'll be ready in about a month and a half Blue Yeti for the win if a lot of people are loving the fact that I'm using a Blue Yeti there it is it's my favorite microphone I used to use the blue snowball but I prefer the Yeti. Galaxa Minor the wants to know how the food is in the Philippines and when I'm not talking I'm listening to Anthony he's feeding me the next question in my headphones so I'm not just sitting there in La La Land in case you're wondering so the food in the Philippines is very Western I you know have a burrito for lunch I can eat pumpkin soup there's a lot of choice here we have TGI Fridays we have McDonald's but I don't eat out of McDonald's we have most of the Western brands including Wendy's and Burger King but I prefer a healthier food and so I usually go for things like soups or like salads or burritos you can go to our freedom store which is at www.freedom.tm slash store let me just make sure that link actually works I haven't tested it in a long time freedom.tm slash store nope that doesn't work scratch that try any dot TV a and y dot TV slash store and that doesn't work either wow that's pretty bad is it shop dot any TV let's let's let's figure out which one of these is the correct one store dot any dot TV nope all right I don't know where the freedom store is where you can buy shirts that's pretty sad sorry about that well that's just a symbol we use to catch people's attention we figure if you see a bunch of titles and one or two have a star it'll look more interesting to click on so it's just a technique we use to make our videos stand out among the list of videos when you when you see them in search results and I encourage anyone to try to pick a cool symbol that can help your videos stand out in in lists as opposed to what kind of videos do you think well I prefer a green screen because it allows me to express what I'm talking about when I say look behind me and if I didn't have a green screen then I couldn't do that so I I also found the freedom store where you can buy freedom items it's on the zazzle.com website so just do a search for zazzle freedom store I think that's what I googled and you can find it let me see oh sorry search for zazzle any TV store a and y TV and then you'll see something that says any TV white


Are you finding your videos lacking something? I don't mean a budget or fancy VFX, but maybe your work is starting to all look the same as each other. Hey, it's Herman here again with Artlist, and if you shoot a lot of videos like me, then you start prioritizing efficiency over creativity. Whether it's commercial work or narratives, I just find myself developing the habit of always pulling out the same techniques and playing it safe, mostly to make sure that I hit deadlines and not disappoint my client. Now the cost of being a well-oiled machine is that we forget about the tools that we've left behind. Here are five techniques that don't get as much attention as they deserve, but like James Bond, they can act as secret weapons that improve your storytelling through video. The first one is the anti-frame, and it's a term I haven't heard in so long that I was convinced I made it up until I found this Reddit comment. Glad I'm not insane, yet. The anti-frame isn't just the clever use of negative space, but also the direction your subject is facing. Normally, you'll have your subject facing toward the negative space, which provides balance in the frame and feels natural to look at. Anti-framing is unnatural as you have your subject facing the edge of frame, giving a sense of loneliness. I wish I could take out my dog for a walk. Too bad the weather reminded me I don't have one. I see this used often in movies or TV shows to let the viewers know that something is a little bit off or that there's a disconnect between the subject and everything else. You might not use this technique when talking to a camera like I am right now, but for moments that you want to create a sense of isolation, it's perfect for your next narrative film, documentary, or even social media. Next we have The Crash Zoom, which is a term for zooming in or out really quickly. You're probably familiar with this wacky technique if you watched Quentin Tarantino's films, but outside of his work, zooming that fast almost feels like committing a crime. However, I think that it's one of the most underrated techniques because you can accomplish so many things with it. In narrative work, it's a great way to add intensity to your scene by quickly delivering new information. In TV shows, it can be comic relief as it hyper-focuses on the character's reaction to amplify the funny. For social media, it's a great way to quickly direct the viewer's attention for coverage. The zoom on smartphones lately are way too good to not take advantage of this. My favorite thing about The Crash Zoom is that you can hide an invisible cut to make sure that you get your perfect shot. Just end your first shot with a fast zoom and start your second shot with a fast zoom as well. Then make a cut in the edit to stitch the shots together into one seamless masterpiece. When I first started making videos, I felt like a horse chasing after the cinematic look like a dangling carrot. And shooting with shallow depth of field made me feel like a master cinematographer. But I saw deception in those blurry backgrounds because years later, I realized that using deep focus is the mark of an experienced creator. Deep focus is when everything in the frame is in focus and relies on other elements like composition, staging, set deck, and lighting to create visual interest. I first noticed this technique in Wes Anderson's films and realized how much more engaged I was because everything's in focus. Now to accomplish this, you just have to close down your f-stop as far as you can while correctly exposing your scene to compensate. But if you're lazy like me, then smartphone cameras try to keep everything in focus by default. So filming on there is the perfect way to practice deep focus compositions.  This next technique is actually used by many modern creators, but only for one purpose. To cut up moments like these between your talking headshots, that's right, I'm talking about the junk cut. It's an editing technique where you break up a single shot and cut away a segment of time from it. Now, how can it be underrated if it's used so often? Like I said, it's because I only see it being used for one purpose, which to me is like using water to only wash your hands. You can drink it, water your plants, have it, ruin your day. You get the idea. Jump cuts are a great way to show the passage of time and only highlight what's worth showing to your viewers. It's also a great way to create a sense of urgency by using it as a montage. If you work on music videos, you can use jump cuts on the beat of the music to create a satisfying experience. Here's an example with a song that I used from Artlist. Be careful though, because when used too often, jump cuts can make people feel like they just wrote the worst roller coaster of their life. But for the right moments, people would think that you're the James Bond of video editing. Okay, at least I will. The last technique I think is highly underrated is the static shot. Really, Herman? The last technique is just to throw your camera on a tripod. Now, in an era where filmmaking tools like gimbals, sliders, and drones are in the hands of many creators, we can be addicted to camera movements. I swear, it's becoming a drug more addictive than caffeine and there's probably more camera equipment brands than Starbucks in your local downtown. Don't get me wrong, I'm guilty of this as well because I've always believed that something needs to move in your shot if you're shooting videos instead of pictures. But that thing that's moving in your frame doesn't have to be your camera. Just like deep focus, there are other things to rely on in your scene like the staging of actors. Without camera movement, we pay greater attention to the things that do move. So next time that you're shooting something, I encourage you to just let go of the camera and try to do something interesting. Okay, you know what I mean. Now, we only went over five techniques, but here are a few more for you to look up and try out. Let me know in the comments if you'd like to see a video about these techniques as well. Although I believe that these are underrated techniques, I do think that they should be used sparingly. Playing it safe was how my brain started rotting. So I hope that trying these cinematic techniques can be a fun creative exercise for you to improve your videos. What do you think is an underrated cinematic technique? Let us know in the comments. And if you wanna see more videos like this, then make sure to subscribe to the Artlist channel. Also, make sure to check out Artlist and get everything you need to create amazing videos from music and sound effects to footage, templates and apps, the links in the description. Thank you all for watching and I'll see you in the next one.


Hello everyone and welcome to a video I really didn't expect to make. I've just recorded what I thought was going to be tonight's video and it probably might still be. Fingers crossed. But something came to my attention. Now Frontier have just posted this on their forums and actually it was brought to my attention because EvoSquad posted it on Twitter. So thank you for doing this. At least posting what you thought was just, ah check this out. It's like wait a minute video idea. So we're going to get into, you've probably seen the thumbnail tile so you know what we're going to get into. But first, let's build up the hype shall we? So as you can see this is the zoomed in version of the forum. So we're just going to go over it really quickly. I don't want to make this too much of a long video because money. Anyway, welcome back park managers. We are very excited to bring you a new Dress Up World Evolution 2 feature focus. Previously we talked about the various improvements that have been made to the guide. You can add to your parks. This week we're taking a look at where you'll be building your parks. It's time to talk about environment. Something that we've often speculated like is there a big difference because you know we've had stuff in the past like the different islands and it's just you know Takano and Sorner and stuff and they really felt the same but actually in Evolution 2 you know we're getting all these different environments and we don't really know too much about them apart from maybe the storms will be different. You know snow storm you get a dust storm and stuff like that. Or at least in my head anyway. Dress Up World Evolution 2 will let you build Desert. Here we go. Desert. The desert environment will be the first place you go when you start up Dress Up World Evolution 2's campaign mode. So interesting first thing to know. You will be able to build a desert park in sandbox challenge and chaos theory modes. It's inspired by the real life Sonoran Desert. Okay well we're learning so much today with its dry climate and flat terrain. Expect to see a lot of cacti and shrubs that would usually thrive in desert environments alongside dirt, sand and the occasional rock and tumbleweed. There won't be a lot of rain but you may be forced to tackle the odd sandstorm. It's a bit like what we've had before. Instead of a thunderstorm it'll be a sandstorm which can gum up the works on your vehicles and cause a bit of damage. Interesting so that's what's going to be the difference here. You'll see the sandstorm coming in, growing in density as it whips up the dirt and sand around your dinosaurs and buildings. Interesting because you have a bit of a time to prepare. It'll be interesting to see you know you got the far off look in the environment a bit like you can see in the San Diego here. Being just see like a huge cloud of wall coming towards you. That would be so cool. So there we go so that's desert so not too much different you know it's all right. Tiger or Tigea whatever you want to call it basically like tundra. The Tigea environment is inspired by mountains forests of British Columbia and Canada. You'll get to build and house dinosaurs in a Tigea environment in campaign sandbox and challenge mode. Not you'll notice chaos theory mode. It's quite a different environment from the desert offering shades of green and urban pines in addition to snow covered peaks in the background. Expect sunshine and dense forestation around you as you build your parks and facilities. Tigea introduces one of the other new calamity types snow storms. Interesting now we've seen this with the first campaign that was able to play when it was the Carnotauruses although I didn't see you know it was snow but I didn't really know it was too much of how it affected me because I didn't really have a park. When a snow storm sweeps in over the area you'll see thick snowflakes falling from the sky and snow piling up on the ground and on building surfaces. If you've ever wanted to see dinosaurs in the snow this is the environment for you. So no idea how that affects you just that it's an aesthetic. I'm assuming it'll be more than that though. And you got a lovely little picture there. Nothing new I think we've seen this this shows some sort of T-Rex looking dinosaur there I'm really not too sure what that is but the Avery is being highlighted and the Lagoon. Maybe this is one of the first images that showed the Lagoon. I don't think it was but definitely definitely one of the second or first pictures. And Temperate. This is where we get into the meat and bones of the video. So Temperate as we continue our journey through just what we're publishing to his environment we come to the temperate environment warmer than Taiga or Teji or whatever it is I don't know. Words but not as warm as a desert. It could very well be the perfect spot to build a dinosaur park or facility. You'll head into temperate environments in campaign, challenge mode and sandbox mode again not chaos theory which is interesting okay. Exploring so you've got three environments and only one of them will be in chaos meaning you know San Diego. Exploring it from different locations based on the mode. The temperate environment is characterized by lush and leafy trees and a warm sun shining down from the blue skies. While there will be less snow you should expect some mist and maybe the odd rainstorm. So rainstorm, snowstorm and desert storm basically. What you really need to be careful of though are the tornadoes. Interest okay so we get tornadoes in this one and so this is the most dangerous one to build in I assume but be interesting if there was like a perk to that maybe you know having the forest for the herbivores might be easier but you know you've got tornadoes to contend with and as you can see in this image you get a close-up of how the jarrus field the tours were going over paths which is lovely because I don't know too many people have highlighted that but it's definitely there I mentioned it once I think generators but really and I'll probably bring up a better image because this one's a bit pixelated when I've zoomed in there is a lagoon and in this lagoon not only do you have the hatchery and stuff but there is a shape there's a shape there now if we think about our creatures that we have we have mosasaurus mystery mosasaurus could be a talus or we've got the pleasiosaurus we've recently had confirmed a light pluridon so you've got mosasaur light pluridon pleasiosaurus and alasmosaur now alasmosaur might have its own unique animation because that was lumped in with light pluridon and I think he said that he wanted them to have unique animations or at least you know to be more realistic so I wouldn't be surprised if we see light pluridon with a similar pain scheme to walk with dinosaurs but obviously I can't do it because you know copyright but the shape that is sticking out of that water is a shark shape it's a shark thin shape more specifically um and I'm really trying to think of like no it can't be it can't be right it can't be megalodon because you know that's not dinosaurs it's prehistoric but we're sticking with you know dinosaurs in this era um you know even though we have snow we have no mammoths we have no sabre tooth cats it's all Jurassic Triassic Cretaceous time periods and we know that megalodon was not in those periods but if you look at it I'm like you've got in the middle here you've got the shark feeder um now I don't know if that has anything to do with this because to the right of it you've got a fish feeder um and I did make a mosasaur feeder in my playthrough and had to go from the outside of the lagoon into the middle and that's where the mosasaur jumped up and ate it right but this time whatever this shark fin shape it can't be a mosasaur going back down that's my only thing I'm thinking it could be because the on the right side there is no pole for the shark to come out it has to be a shark fin which means now we haven't we've kind of been we've got a lot of aquatics let's be honest a lot of aquatics more than I was expecting a launch anyway you know uh pleaser saw attenborough saws mosasaur mystery mosasaur like pluridon lasmus well that's six out of a 70 dinosaurs we're going to get a base 72 I think it is maybe one of them is megalodon and I wouldn't be surprised if it was megalodon I mean now that we've got lagoons it's always been the biggest thing joseph park builder megalodon joseph world the game a megalodon they all came to it and joseph world life of course doesn't have because there's no aquatics but this game has the potential and I'm excited to see a megalodon take on a mosasaur because the megalodon would definitely win that I'm I'm pretty sure again we're talking about mosasaur from draca but it has to be and I cannot think like a pleaser saw putting its fin out the water maybe I like pluridon put like breaking its neck and just sticking its snoot out like a mosasaur if it was to do that it would you just see the rest of it it has I can't honestly let me know the comments down below am I going insane that's a mosasaur it has to be anyway anyway and and finally finishing off you have the tropical it wouldn't quite be an authentic draca world gaming experience without a tropical environment inspired by the Hawaiian islands of uh oh how and kawaii I think it's oh I'm butchering that name the tropical environment isn't featured in the campaign uh but we'll depict isla nublot and sauna in chaos theory and sandbox modes so there I'm pretty sure isla nublot and sauna in chaos theory modes is talking about Jurassic park what if scenario and Jurassic park three what if scenario so we're definitely going to be going back to those and sandbox uh because sandbox will pretty much let you choose whatever I'm sure as you would expect this environment is sunny and quite warm offering up a beautiful climate for both of your guests and dinosaurs but mindful that there's potential of tropical storms and hurricanes heavy swirling rain will come blowing in on howling winds causing damage to its surroundings don't forget to keep some extra shelters open just in case and the oh god and here's another one alpine finally there's the alpine environment large mountains towering over green hills and valleys and a bright sun shines down from a blue sky and the yellowstone inspired environment you'll get to play around in the alpine environment in campaign challenge mode and sandbox again not chaos theory the alpine environments bright sunshine is broken up now and again by some light rain and you may need to contend with the odd snow and rainstorm when building up these environments uh and then that's it for Jurassic world version two feature focus uh of the five environments we've shown you which one started to you uh do you think there's anything extra no pre-orders November that you have it so i think they've deliberately put in megalodon now they do this they they they leave at least a rags in i mean even if you look at this there's like a hay bale or like a semi-circle lump in the uh it could just be a rock to be fair in the parasaur enclosure there it's it's more than likely a rock i would assume um but i let me know what you think man i think that's a megalodon i i really don't see it being anything else uh i i maybe they didn't notice it but frontier are very clever about sneaking in little things here and there um like they've always like with the lagoon they showcase the lagoon in an image like this but it was very slim very slim and this time again they're like you know let's put a megalodon in let's we're gonna hide this to the end but if somebody can spot it they get the views but there we guys leave me know let me know what you think uh i don't want to put this on too long it'll not be heavily edited either because it doesn't have to be um and hopefully i'll you know have another video tonight we'll see we'll see if you're good and if you like tell me what your thoughts are i i i don't i haven't done this for clicks i don't think i think that is legit it it can't be zooming on that is a megalodon anyway guys until the video you leave like until next time i'll see you cuties later oh bye


A 24-year-old Cass Lake man is charged with murder in the death of a 25-year-old woman. The Cass County attorney has charged Brandon Joseph Roy with one count of second-degree murder without intent while committing a felony, one count of first-degree aggravated robbery, and one count of possessing a firearm for a crime of violence. Roy was rained on those charges today and is being held on bail of $1 million with numerous conditions. Roy is accused of shooting the woman in the head at this home in Cass Lake on Sunday. The woman's identity has not yet been released by authorities. According to the criminal complaint, several people in the house were smoking methamphetamine when Roy and another man tried to rob others in the home. The complaint states that the woman was hit by a gunshot that went through a bathroom door. Authorities are still seeking help from the public with locating three individuals in regards to this homicide investigation. They are 28-year-old Anthony LaRose, 41-year-old Sarah LaRose, and 25-year-old Elisha Ginn. All are from the Cass Lake area. If anyone has any information about the location of any of those individuals, you should contact the Cass County Sheriff's Department.


It is four o'clock, I will call the Licensing Hearing and Public Safety Committee meeting to order. I'll do the roll call. Alder Decker, Alder Ackley. Yeah. Alder Donahue, Alder Felde. Yeah. All right, for those present in the chamber, please stand for the Pledge of Allegiance. I pledge allegiance to the flag of the United States of America and to the republic for which it stands, one nation under God, indivisible with liberty and justice for all. Okay, is there a motion to approve the minutes from October 14th? Done will. Motion by Donahue. Second. Second by Decker. Any further discussion on the minutes from October 14th? All right, seeing none. All those in favor, please say aye. Aye. Aye. Aye. Anyone opposed? Aye. Chair votes aye. The minutes are approved. Okay, 3.1 discussion and possible action regarding the request for beverage operating license application number 3325 for the Sheboygan beer garden for an extension under the city's continuation of business ordinance. Chuck, do you want to take this one? Sure. So technically the beer garden is in violation of our continuation of business ordinance, but that's really because they didn't open up during the pandemic. Under our ordinance, you do have the option of granting a single extension. And staff is recommending that you do grant that extension. We're actually recommending a little longer than Mr. Powers is even asking for just to be safe. We're suggesting granting it through the end of the license year, June 30, 2021. That would deal with any other potentialities and is really pretty much as far as we can go. Is there a motion to approve? Motion to approve. Second. Okay, motion by Dean, second by Barb. Any questions on this one? Obviously, I think the beer garden's been kind of hit with COVID and then as well as a lot of the flooding that's been going down over there. So, and I know that there's discussion and we'll be coming to our committee soon with their moving locations as well. So, any other questions or comments? Seeing none, all those in favor, please state aye. Aye. Anyone opposed? Chair votes aye. That's approved. All right, 3.2 resolution number 107, 2021. A resolution authorizing the purchasing agent to issue a purchase order to purchase of four vehicles for the Chevrolet Police Department. Chief. So this is essentially a regular resolution that's put in every year. The vehicles that Bernie is gonna order are the vehicles that are included in our capital plan. The reason that the order is typically done at this time of year is so that we get the vehicles delivered closest to the start of year as possible. That's the best time for our mechanic and radio technician to be able to switch them over. Because of the pandemic, it's more important that it be done this year because of the backlog that Ford has with getting vehicles delivered. So the vehicles for this year, we didn't get until August this year rather than January. And so they're still being switched over now. So the sooner that we can get the order in the better as the resolution indicates, we would not get take delivery of them before the first of the year. So it would still be purchased and paid for after the first of the year. Any questions for Chief Tomakowski? I have a question. Go for it, Barb. Chief, is there a reason that we go to Hartford for the vehicles because they do the setup on them? Or is there a reason that we don't stay local with it? Yep, we do the setup in-house. The reason that we go through E-walls is because they have the state contract, we get the best pricing through them. Excellent, thank you. All right, any motions? I'll make a motion. All right, is there a second? I'll second. Okay, motion by Dean, second by Barb. All those, any other questions? Seeing none, all those in favor, please state aye. Aye. Aye. Anyone opposed? Chair votes aye, that's approved. Okay, 3.3, our own number 85-2021 by the police chief submitting the quarterly reports. Chief? Okay, so you have the benchmarks in front of you. The highlights are laid out in the IFC part one crime, violent crime continues to be down this year, which is a very good thing. And with the pandemic and people being restricted, it's a surprise to me, but it's a positive thing. So I'll take it. Slight increase of property crime, not something that concerns me though, looking at how far the numbers are down from previous years. So I think we're still doing good there. Traffic accidents are down about 20% part of that, a big part of that I think has to do with the pandemic having less vehicles on the road, especially during the second quarter there. But again, it's a positive thing. And we've held it since past the second quarter. So I think we're gonna see a good reduction for the year. The other thing that's mentioned in there is during this quarter, we've hired six people. So that's a big, all sworn people. It's a big undertaking for us. And besides that, we've hired a new radio technician. So he's been training with us. So we're making good progress on that. As part of our diversity efforts, I would mention that of the six people that we hired, we hired one Asian female, one Asian male. I don't think about this one white male, one white female and two black males. So we have a real good mix of diversity and something that we're really proud of. All really very good candidates. Four of them are still in the academy and we'll be graduating very shortly, one in November here and then three of them in December. So we're excited to have them joining us full time. The other thing that I would say is, I think all of you are probably very aware that we had a very busy quarter, including some protest activity and then some positive activities that we are able to do with the black American community outreach group. So for barbecue, use any unity walk with them. And I think they're really important group for the city. It's really good to see their leadership and the things that they've been trying to do and the opportunities that they bring to the city. So that's what I have for you. If you have questions, I'd be happy to answer, whoa. Ryan, I have a quick question for you. Yep, go for it, Dean. Just wanted to ask, has there been a noticeable rise or anything like that in mental health issues regarding with the COVID? I mean, has there been any impact because of that? So there's an article in the paper. I don't subscribe to the paper so I couldn't read it this morning, but I've had a lot of discussions with them over the last probably two or three months. Mental health issues really have been a consistent issue for us over the last couple of years. We respond to probably nine or 10 calls a day just dealing with serious mental health issues. As a community, I think we're doing much better than we were in the past, both because of the training and how we respond to them. But probably more important is because of the additional local resources that we've seen over the last five years. So I don't think we're in a perfect place, but I think we've seen a lot of good progress being made and hopefully that continues to happen. Any other questions for the Chief? Is there a motion to accept the report? I'll make a motion to accept the report. Okay, motion by Betty. Second. Second by Dean. Any further discussion? Seeing none, all those in favor of accepting the report, please state aye. Aye. Anyone opposed? Chair votes aye. Dance accepted. Thanks, Chief. All right, 3.4, Fire Department quarterly report. Thank you. So during this quarter, obviously do continue to do the COVID, our call volume is fluctuating, but around the same that it was last year, although our overall call volume was only up 1%, 1.5% our AMS calls were down. So it kind of equals out. Fire inspections finally resumed this quarter. So we were back into the buildings slowly and we found about 28 of the occupancies that were non-compliant with the appropriate working smoke detectors. So the crews installed about 32 detectors during this period. And as we continue with the COVID issue, we're going to see less and less ability to go into the schools. So our public education programs did, we went to a virtual profile and submitted several PowerPoints, slides, brochures that the teachers themselves could teach the students or bring up for the students instead of us having to be in the schools. So that's where we're at. So if you have any questions, please let me know. Any questions for the fire chief? Seeing none, is there a motion to accept the report? Motion to accept. Second. Motion by Dean, second by Barb. Any further comments or questions for the fire chief? Seeing none, all those in favor of accepting the report, please state aye. Aye. Anyone opposed? Chair votes aye. That's accepted. All right, building inspection. Chad? So thank you chair. So we are, when we look at the revenues of the building inspection division, we're about 80,000 behind in a year to date where we were last year, although the number of permits is substantially higher. So the total number of permits issued this year so far is 22,808. Last year at this time we were at 1,663. So some of that might be the timing of the projects. We do have the Oscar Apartments Development on the south side that is a substantial amount of permitting dollars that will be coming in. So we project that we're going to be somewhere in the neighborhood of about a million dollars when we're done at the end of the year for total revenues. As you can see, it's very similar to where we were in 2018, but not as high as where we closed out 2019 at 1.3 million. So we're optimistic that we're gonna close out the year and be able to get us to the million mark, but we'll see we budget about 650,000 a year. So we're ahead of that. When we look at the code compliance to date, we've done 6,004 inspections. Her goal is 7,500. And then we still continue working with people on housing inspections and housing violations and nuisance. So the two part-time code enforcement officers and the two building inspectors are still working through our targeted neighborhoods as part of the strategic plan. So you can see the numbers for nuisance and sanitation orders are very similar to where we were previous years. The only, I think, difference is that under sanitation and nuisance orders, the citations are lower than previous years. And we're probably not gonna get to our goal, but that's not an all bad thing because it means people are compliant and we're not having to move into the citation area. When we look at the housing inspections, our goal was 700, we're close to that with 653. And our citations are very comparable to where we were this year, this time last year. So I think housing is a little bit more detailed inspection and violations than just garbage in off-street parking issues, but we continue to chip away at it. So that's it in a nutshell. If anybody has any questions, I'd be happy to answer them. Any questions for Chad? All right, thanks Chad. All right, city attorney. You've got our numbers in front of you, or at least they were provided to you. We're about where we expect we would be. A lot of the numbers, a lot of our numbers are really not generated by us, but it's just simply based on requests that we get. There are a few new numbers that we've begun to report for 2020. I can answer any questions that you might have, but there's nothing there that's a surprise. Questions for the city attorney? All right, 3.7, RO number 47, 2021, submitting various license applications for the period ending April 14th, 2021, June 30th, 2021 and June 30th, 2022, Class B liquor license, new application number 3458. This is the Seoul and Nova application, which has been hanging out there for a while, and they have now updated it. Apparently they were out of town for a while. They've updated it, so staff is recommending that we grant the license contingent upon Vernon Kittler adding his list of felony convictions to the auxiliary questionnaire where the information is required, but not provided. That's not enough for us to hold it. He just needs to fix it before they pick up the license. Is there a motion to approve? Motion to approve with staff recommendations. All right. Second. Second by Barb. Any further discussions? Seeing none, all those in favor, please state aye. Aye. Anyone opposed? Chair votes aye. That is approved. 3.8, RO number 76, 2021, submitting various license applications for the period ending June 30th, 2020, new 2022, beverage operating license application number 3355. This is John Kubardulis, which we've held for some time. We're recommending continuing to hold this one. Mr. Kubardulis has not re-contacted us and the PD has been running into some issues getting information from Virginia on a conviction. They are continuing to work on that and we will be sending another letter out to Mr. Kubardulis, so the recommendation is to hold. What information are you guys trying to get from Virginia? He has a conviction, but we don't know what it's for because he didn't tell us, so we have no way of knowing whether it's related to the license activity or not. Okay. Or the nature of it or how serious it is, that kind of thing. Sure. Is there a motion? Don't move. Second. Second. Okay, a motion by Mary Lynn, second by Betty. Any further discussion on this item? Seeing none, all those in favor, please state aye. Aye. Anyone opposed? Chair votes aye, that is approved. All right, 3.9 RO number 86, 2021, submitting various license applications for the period ending December 30th, 2020, June 30th, 2022. This is the larger RO and staff is recommending granting all of the licenses on the RO except that the taxicab license of Molly Jane M. Johnson be granted with a warning, that's due to her 2020 conviction for obstructing, and that the taxicab license of Cheyenne M. Lip should be held pending a plea hearing that she has scheduled and a number of serious charges, including some felonies. So we wanna wait to see what happens with those. That's our recommendation. I move to adopt the recommendations. Second. Second. All right, there's been a motion and second. Any further discussion? Seeing none, all those in favor, please state aye. Aye. Anyone opposed? Chair votes aye, that is approved. Seeing that we've exhausted the agenda and there are no more questions or nothing else on the agenda, is there a motion to adjourn? Motion to adjourn. Is there a second? Second. All right, there's been a motion in multiple seconds. All those in favor of adjourning, please state aye. Aye. Anyone opposed? Chair votes aye. We are adjourned at 418.