Hi everyone, Joe for jaspyscasebreaks.com with a brand new release, 2020 upper deck Goodwin Champions, six box random letter break number two from jaspyscasebreaks.com. We sold 14 spots, only numbered cards, LeBron, Jordan base, plus the inserts and the hits will ship. So if there's any discrepancies on letters like animals and artists will be termed by me. So I think it's not going to happen too often, but if there is like an animal card, if there's like an artist autograph card, we're going to go by the artist's name. All right, those are pretty rare. So we're going to go by the artist's name and there's a checklist on cardboardconnection.com. If it's like a non-auto and if it's just the card itself, then we'll go there. Everyone gets a random letter. We go by first name, first letter, first letter, first name. I'm trying to think what else. If there is like, it's a good example, if there's like the bottle nose dolphin, it's not going to go to T. It's going to go to B for bottle nose, right? If it's like a card with a phrase on it, it'll just be the first letter of whatever it is. Like astronauts go to Mars, it'll be A. You know, here's the STS-132 cover all. It'll go to S. I think it'll be relatively obvious, but we're not going to use the definitive article, the, the, the, which is a good 80 synth pop group right here. Big thanks to all of these folks for getting into break number two. There are the letters right there and this group will get all the letters not on the list as well. So let's roll it. Let's randomize it five and four, nine times for each list. One, two, three, four, five, six, seven, eight, and ninth and final time. Five and a four, nine times. There we go. There's nine Stacey down to Vipple and nine times for the letters, ninth and final time. There you go. After nine, we've got S down to W. All right. So Stacey with S. So Stacey, if we pull any Stacey cards, it'll go to you, S. Zach with V, Josh with A, Russell with T, Kevin with R, Mark with D, Travis with B, Derek you have I, F, E, plus all other letters that aren't on this list. Adam, Last Bud Mojo, Profits and Losses, P and L, Travis with M, Tony with C, Juan with N, Travis with J, and Vipple with W. Remember, these are first letters of their first names. Let's order these alphabetically. Now here's another twist. If you're just joining us on these upper deck, Goodwin, champions break, brand new release just dropped today. We're going to flip screens just for a second. These are actually eight box cases, but we're doing six box breaks. I think we'll eventually catch up by break number eight. So here's two boxes from the previous inner that Jason opened up. So then we're going to do half of this four boxes to make six total for random letter two. So let's pop these open. My knife right there. We've got twins cubs on the TV in the background. Just scrimmage game just started. And then the official season starts tomorrow. All right, so we'll roll the die. We'll go one, two, three for the left four and four, five, six for the right four. I'm going to use that Bellagio die right there. And it's six, one, two, three, four, five, six. And this will save four. Wilson Contreras just hit a home run. So we'll put some Xs on those little mini cards right there. Save that for next time. All right, so now we've got six. All right, I'm going to go back to this. I'm going to pause the video really quick. And when we come back, we're going to see if there's any letter trades. And then we'll have the break. So stick around. All right, welcome back, folks. Six box random letter number two. No deals were done checklist. We were studying that while we had the video pause checklist. I'll drop back into the chat again. I think everyone I think everyone gets it. So we've got curtain call relics. We've got some old currency right here. Some ASOP's fables. All sorts of new C creatures. Damn. There you go. There's a bounty that you can chase to. Sure details are on the, on the upper deck website. Take all of them. Take all of them. That would have been on the record. That would have been on the Jaspy's blooper reel. You're right. That's good. That's a good not top ten. Or what's the Polly's? Bloopers? Polly's? I don't know. I don't know what that music is. No, I know what it means. I don't know what the music, the theme music is for like MLB Folly's or bloopers. Do they have that? I don't know. These are terrible. Just too intense. Yeah. I know they're terrible. The packs, what's inside the packs, folks. Pretty great. Jaspy's casebreaks.com. We got more of this to get into it. Pretty rough. Petition. Don't buy it. I've changed that already. Yeah. Those Donner's optic packs were smooth. Those opened up fast. They know what to do. Bowman is great. I got the terries. Bowman packs full. And they got the normal. It's too much glue right here, but then the pack itself is too flimsy. So it'll like, I don't know. You gotta sit down for this. I know. I almost fell too. That would have been terrible. Marlon Gonzalez. We got, I don't know. The gaudy tiger animal. Ghost of tea. It's my first good one today. We got a mini. We got Rose LaVelle for R. R. Kevin with that one.  There's, I don't know who this lady is. Jenny Andrade. Apparently one of the most popular personalities to mix martial arts. I'm gonna go to Jay. So like the king will go to K. That makes sense, right? Although will this even ship? Is this like a base card? Well, base cards don't ship anyway. But this will ship, right? That's one of those color cows or whatever. That will ship, that's black and white. Mini's will ship. Darius Garland will ship. Tiger will ship. You see Shaquille O'Neal in that commercial Atoni the Tiger. He's in the commercial Atoni the Tiger. It's great. That's the tagline. And there's a man in Reume M. With that one, that'll go to Travis. And these are neat. Heads of state, Benjamin Franklin. Vintage stamp. Nice. B, Travis Dowell. No one of these in there. I will top-load this later. All right, so good job B, Travis, once again. Man, I don't understand your question, Brandon Richards. Are you saying how do you determine insert base from regular base? Veteran commons are just the regular veteran common cards. Those won't ship. And then inserts are different from the commons. So they just look like inserts. They'll be something different. And a cat. The black panther. Nice. B, Travis. Wow, that's Ben Franklin's 100 bucks. 100 to 150? That's awesome. I know that sometimes these do shockingly well as well. Some people might be surprised. And an autograph. We've got Jin Yu Frey. What are they? This size. Did you? Yeah. Wow. Travis Dao. The letter Dre. Dre? J, that is. I don't know, is she a fighter? I have no idea who she is. Oh, boom, there she is right here. MMA, yeah. There you go, that's what she's about. There's Megan Rapinoe.  I apologize. Marco, we miss having you here too. Oh, I see, I see. That'd be a way to get into the shop. Apply for a job and get hired. It's a different surface on here. Almost like wood. Is it wood? Or is it just artificially textured to be that way? But that'll go to J, that's pretty cool. Well, we're still remodeling here and then eventually I'll let us open back up, I guess, in California. Marco, are you guys still open? Can you still do your thing? I feel like that's, you are still, okay, I was gonna say, I feel like you guys still fall under that the essentialness animal services and whatnot. So Nick allegedly hit a monster in here. So let's see what he was talking about. That's what he thought he saw a monster in here. Let's see what the monster could be. It's a monster. Is it like certified? Like it's an actual monster? Like is it like a sea creature monster? Like a giant squid? Or is it a monster as in, is it a high value hit? Oh my God, that's a monster. It's right there. There's Timothy Way. That'll be for T, Russell Green. Who has this letter? Did everyone see it? Did you see it? I think there's a 180. Wow. You saw it? I saw it. It's a monster, not a sea creature monster, but like a monster monster. Like a big hit monster. Oh, Jason Dominguez, 88 out of 99. Exquisite rookie autographs. This is kind of an old design, isn't it? Yeah, it's a vintage design. Yeah, that's awesome. It's got a relic in there too. Looks like leather. Maybe a piece of a batting glove or his actual glove. Not his gamer though. They wouldn't give up a gamer for a set like this unless they're retiring it. Letter J, Travis. That's awesome. All these Jordans will ship too. I know I'm missing some of those, but in the interest of time, we're gonna breeze through these. And there's Ken Jennings for K. Another one of those wood textured minis. That will be for, all other letters not on the list, Derek with the Ken Jennings. And there's these 3D cards, which are kind of wild. We've got Jesse Lebrek who's on America Ninja Ward. Yeah, I thought. Is it because I'm not opening the packs? Yeah. That way it took Jason so long. Jason's usually fast. Oh, it's the worst when your thumbs start to peel back from the skin. People say, oh, I like looking at him. Yeah, you can do good wind champions for me all day long. Ooh, another stamp. That's Umberto, the first, the old King of Italy. It's a vintage, I think it's an actual stamp stamp. So this is a stamp from the 1800s. Umberto became King of Italy upon his father's death in 1878. I don't know if he was a nice guy. Oh, it was not popular with the large portion of the people due to his lack of compassion for the poor and working class. Oh, we don't like him then. After his orders resulted in the deaths of hundreds of demonstrators. He would not do well this day and age. No, he was killed by Italian board anarchist, Gattano Breschi on July 29th, 1900. Yeah, let's go back to a true patriot. Yeah, Teddy Roosevelt. Ben Franklin, founding father. We like Ben Franklin. He like, he, he put a, he flew a kite into this guy with a, with a key on it for, does he really, I thought he was, I thought he was into those guys. He like everyone in that generation did, right? There's a man in a reyume, hockey player, and she's going to go to letter M, Travis. Travis Dowell having a nice break so far. LeBron Mini, I feel like attractive women in sets always throw me off. Cause we spend 99% of our time looking at dudes.  It's a good one. Wow, look at this, the giant grouper. Oh, yeah, what a gross animal. Can you eat this? That goes to G. Wow, a colorful fish in its youth. The giant grouper quickly turns a drab gray hue with age, just like humans. These fish are uniquely capable of gender transitioning when there is an inadequate quantity of males. Very 2020 of this fish. Modern fish. MTG says they're illegal to catch, so much for that. Letter G is not on the list, so that'll go to Derek, who has the, all other letters not on the list spot. Hi, Jason's a nice guy. Nice, thank you so much. Oh, as long as the cards are safe. There's Ben Simmons, and that sort of wood, I don't know what these are called.  That's what, now Cooper's saying, you can eat it. You can catch them, so it's a catch and release. But, Coop says you can eat it.  There's Jamie Dwyer, field hockey. Jay, Travis. Oh, those are lumberjack cards. Oh, that's right, it says on the back right here. Is it actual wood, you think? Or is it just a plastic coating textured like wood? The blanks are thinner this year. Then what upper deck usually uses, just in case you were tracking that. Oh, another cat. The Marge, who's got cat mojo, M, Travis Dow. I don't think I have enough top blowers for all these thick cards here, but another cat. Some of these could be really short printed, and hence really valuable. The Marge lives in the forests of Central and South America. Lives in solitude, hunts at night, loves climb trees. Used to extraordinary, sophisticated cat eyes to see long distances. Has a near threatened conservation status. And we've got John Bucci Gross, a media personality. I don't know who he is, but there he is. All right, one more box to do. There's the Lumberjack Tiger for T, Michael Jordan Mini. We've got Phil Dahlhauser, beach volleyball player. P, Adam Cofferman. Adam also has L. There it goes. And wow, a second, Jason Dominguez. Travis Dow with the letter J. Had the old exquisite patch auto in and now gets the gaudy Jason Dominguez on-card autograph. Woo, nice. And we got sport royalty, nice. Megan Rapino, dual rally, excellent soccer player. M, Travis. All right, and there you have it. Quick little recap here. We'll get all the proper top blowers for the non-top loaded stuff, but nice Jason Dominguez autograph. I like the cats. The 3D stuff is cool. The stamps are pretty sick. We don't like this guy historically, but the hit itself is nice. There's Jason Dominguez, another relic, another autograph, relic. We got some sea creatures. The 3D cards are pretty cool too. There's the giant grouper. I wanna find more sea creatures. I'm into that. Another cat and LeBron James Gaudy. So a lot of cool stuff out of here. Thanks for watching. Thanks for breaking with us. I'm Joe for jaspyscasebreaks.com and I'll see you next time for the next one. Bye-bye.


Family Theatre presents Ruth Hussie and Stephen McNally. From Hollywood, the Mutual Network in Cooperation with Family Theatre presents Big Day starring Stephen McNally. And now, here is your hostess, Ruth Hussie. Thank you, Tony LaFranco. Family Theatre's only purpose is to bring to everyone's attention a practice that must become an important part of our lives if we're to win peace for ourselves, peace for our families, and peace for the world. Family Theatre urges you to pray. Pray together as a family. Now to our transcribed drama, Big Day starring Stephen McNally as Jim. It started with what I thought was a toothache. That was last Sunday, just a week ago. I'd taken Jimmy to the doubleheader against Cleveland and when we got home there was a plate of cold chicken in the icebox and a note on the kitchen table from Eleanor. It opened from Sturges this afternoon and mom's got another of her headaches so I'm going over to help with dinner. I'll be home by 10. George will drive me. P.S. Don't eat all the chicken. It was still light when Jim and I finished the dishes and I told him he could ride his bike to late 30. After he left I went out back and turned on the sprinklers. The rose climber that Eleanor had put in last fall had almost doubled in size. The blooms were yellow, almost a dozen of them, some as big as your fist. I let the sprinklers run for about 10 minutes then I went back into the house and looked through the Sunday paper. Jimmy didn't get home till almost 9 so I bawled him out and sent him to bed. By 9.30 I realized I wasn't going to make it myself so I left a note for Eleanor and went upstairs. I was asleep before I hit the pillow. When the pain woke me it was half to 3 a.m. Oh brother. What's the matter honey? There's a toothache. Man oh man, I gotta get an aspirin. Has it been bothering you? No, it's just me now. Why way in the back. Jim is it really bad? Yeah it'll do. Where are the slippers? Don't mind I'll get the aspirin. No I want to take a look at it anyway. It feels like a wisdom tooth. Why don't you put a few drops of that liquid camphor on it?  Could be some in the medicine cabinet. Ooh. All right wait a minute. Hey where is the wisdom in a wisdom tooth? Here just rub a little on the gum. Wait a minute wait a minute. I want to take a look at it. You feel swollen? It just hurts. Yeah I don't see any inflammation. Isn't tomorrow that luncheon with McGovern? I'll chew on the other side. Well by the way I told Lillian and George about your promotion. I was nice and catty about it.  No sort of. But when I let it drop that you are now a $15,000 a year maniac Lillian dried up pretty fast. Ooh. Oh it still hurts doesn't it? Yeah a little. I'll call Williams and Mara. You were there for a checkup just last Christmas. Funny you didn't see anything. Probably came up since then. I suppose. I'd better take a couple of vassals and try to get some more sleep. How many do you want two? Yeah I've got a big day coming up. Big day. One of the biggest. Lunch with Mr. Henry McGovern of McGovern Tool and Die. And it went well. He renewed the agency contract for another year and doubled the budget for magazine space. Back at the office I showed him the art and copy for the fall campaign and he aided up. I dropped Mr. McGovern back at his hotel and took a cab over to the dentist's office. Dr. Williams had said any time after three. How long have you had this pain Mr. Davis?  I see. Do you have a family doctor? For Jimmy. Most of what Eleanor and I seem to catch we can knock out with cough syrup boy. Well I'd like to make an appointment for you with a Dr. Weldon. Do you know of him? Another dentist? He's an MD, Dr. George Weldon. I'd like to have him give you an examination just to cover all the bases. Why, you don't think it's the truth? Well it's possible of course but there's no sign of abscess or inflammation. Let's see what Weldon thinks, huh? I don't know why but I didn't mention the appointment with Dr. Weldon when I got home that night. Maybe I had a premonition. Oh I don't really think so but it must have been something. Anyway I told Eleanor that Williams had given me stuff to kill the pain, everything was fine. But it wasn't fine at all. Something inside my head was stirring and throbbing. It seemed to me spreading. But I didn't know what it was. Not last Monday night or even the next afternoon when Dr. Weldon examined me. I waited through Wednesday for the results of the test. Then Thursday afternoon sitting in his office the sun's sliding down through the blinds over his heavy mahogany desk. Dr. Weldon gave it to me. Mr. Davis, you know, suffering from a disease called leukemia. In your case it's moving fast. This... there's no mistake. I'm afraid not. Good Lord. I explained the action of the disease to you first without naming it because... I know. I... I guessed you. Coming up to something. Do you have a family? Wife and son they... I just got a promotion. Is it certain that I... In cases like this it's pretty certain, Mr. Davis, yes. I have to tell you the truth when it's someone with responsibilities in the home. You have to be frank. I know. How old are you? Are you older than I am? Forty-three. I'm only thirty-nine. You've still got your hair. I don't know what to do. Do you want me to tell your wife? Hold on. I... I don't know. No, no, I... I'll tell her. I... What do I tell her? What do I got? Six months? No. I'm afraid you haven't got anything like that. A closer to one month. Maybe even less. I told you it was moving fast. I can't do everything in a month. I... I thought it was just a toothache. There's something I hadn't noticed about myself. It's something about leukemia.  And the pain starts to spread. You can get used to that, even fool people about the pain, but not the weight. All they have to do is look at you from one day to the next. And the next day was Friday. Jim, would you look over these sketches? Yeah, you bet. This is just rough, but I want to see how it hits you. Well, it's awful darn good. I understand old man McGovern liked the new campaign. He sure did. See, have you ever met him? Yeah, last year at the big climb bank in Chicago. But I don't think he'd know me. I think it's a good idea if you get to know him a little better. He's in town till next Wednesday. I'm going to set up a luncheon date. Me and the old man? Yeah, the three of us. He's always patting me on the back for your ideas. I think you ought to meet you, Will. But Jim, look, I'm strictly a backstage character in this campaign. Yeah, and maybe that's what's wrong with it. The day may come. Well, you may have to deal directly with McGovern and a lot of other clients. He's not the nightmare a lot of people make it out to be. Well, it looks like he's warned you down pretty good this week. Does it? Well, no offense, Jim, but I... No, I'm just asking. Can you really see a difference? Well, I think so. Well, so he's a little hard on the nerves, but you can deal with him. Yeah. Well, I hope the day when I have to is a long time off. Yeah, you and me will, but you never know. You can't describe it. It's in a class by itself. The knowledge that there's an exact point in time after which you won't be alive anymore. Even if you can't be sure of the day or the hour of little commonplace things, keep reminding you that it's getting nearer. Riding home on the train that afternoon, it suddenly occurred to me that I wouldn't be around to find out who won the World Series this year. And I took off my glasses and rubbed my eyes. As if I had a headache. No one on the train seemed to notice. I guess they had troubles of their own. When I got to the house, Eleanor was standing on the front porch waiting for me. She had on a pink starchy dress with a little white collar, and she was smiling. It was like seeing her for the first time. Boy, did you look like something. Oh, thank you, sir. How things go today? Oh, the usual. Friday's always a hassle, you know. Here, honey, let me take your phone. Yeah, thanks. Say, where's the crown prince? Oh, he's spending the night over at Stewie's. Oh, that's right. That's right. The big fishing expedition. Up and on the road by 5.30 tomorrow morning. I'd like a full-colored snapshot of that one. Yeah. Say, if Junie isn't going to be here tonight, how about us going out to dinner tonight? Wonderful, but I thought you wanted to watch the fights. Oh, I can watch the fights anytime.  You sure you're not too tired, Jim? Why do I? Do I look tired? No, not especially, but I mean, the way your tooth's been acting up and the heavy schedule you had this morning. Oh, my tooth's fine. I'll sleep till noon tomorrow.  You like that number hat? Yeah. Boy, you look good. Jim? What? I love you. We had dinner in a place called the Grove. Back when Eleanor and I first started going out together, we used to eat there. It would be rare occasions when I could afford it. It's got a lot of memories for me. I first met Eleanor at the Grove on a double date, and it's where I proposed to her three years later. Before the war, everybody used to go over there, but tonight it was almost empty.  Want some more coffee? No, thanks. This is still hot. Well, did you get enough to eat? Oh, I'm stuffed. Oh, you and me. You know, I was just thinking. Remember the night we gave that going away party here for Bill Peterson when he joined the Air Force? Yeah, right over there. Well, what was he so mad about? I never heard so much shouting and table pounding in my life. He thought we should join up with him. Remember how we all had to show him our draft cards? Oh, yeah. I didn't understand how he felt until my number came up. Once you're hooked, you want everybody else to get in. Well, you unlisted. Yeah, to cheat the local board. Let's face it. You never did meet his wife, did you? No, I think I was overseas when he came through town again. See, she was real cute. And you wouldn't have known Bill. They dropped by the house and he bounced Jimmy on his knees. Well, he was just a different man. Sadie, do you know if she ever remarried? Well, I'm not sure, but I wouldn't think she'd have much trouble. Let's see, Bill was shot down in 43, wasn't it? 40? Yeah, yeah, 43, yeah. Well, Helen stayed with his family until just a few months before you got home, but she went back to Virginia. Oh, she must be married again by now. Well, I was thinking today, what made me think about it was a story of the paper of a man around my age. You had a heart attack. You know, no warning. But you can pick up the pieces, you know. How do you mean? Well, I mean his wife. She's still young, 35, got a whole lifetime ahead of her. She's got sense enough to do something about it. Yeah, I suppose so. I mean, he left her protected. I suppose it's a shock, but she ought to be able to pick up the pieces, like Bill's wife. Well, they don't even marry to you. How long had this other couple been married? Well, like us, about 15. That's a lot different. Well, maybe, but you just can't stop living. She's got her children to think about. Sooner or later, everybody's got to die.  But I couldn't do it. At the time, I thought it was because I wanted to spare her the shock. But later that night, lying awake, I realized it wasn't Eleanor or Jimmy I was trying to protect. It was me. I didn't want to face it. I wanted to close my eyes and pretend it wasn't there. It wasn't going to happen.  Not even when someone proves it to you. So I got through Saturday. Oh, I mowed the lawn. I watched the ball game on television. That night when Jimmy came home happy and dead tired from the fishing trip, we measured the bass and the perch that he'd caught and put them in the freezer. The next thing I knew, I was lying awake again. Watching the moonlight sprinkle in through the window. Listening to Eleanor breathe evenly in her sleep. Wondering. Wondering what I should do. The next morning was Sunday. We went to church and after Mass was over, I walked Eleanor and Jimmy back to the car. Then something hit me. Listen, I want to stop into the directory and see Father Hughes for a minute. Now? Yeah, it's about the building fund. I told him I can buy. I was looking for a contractor. Why can't you call? It'll only take a few minutes, honey. Well, Jim, I've got a roast in the oven. I'll be right back. I just want to clear this up. I had gone to high school with Joe Hughes and I never cared for him. I thought he was fussy and self-righteous and most of his sermons bored me to death. But I had to talk to someone. Who knows about this? Outside of your doctor? Nobody. You haven't told Eleanor? I told you nobody.  I want to know what to do. You don't have much respect for me, do you, James? Oh, now look, Father James, I... Don't misunderstand. Well, it isn't anything I hold against you. I know I'm not a popular pastor in the accepted sense, but I want to help you. I want very much to help. I've seen other men die. I wanted to inspire them. I was a chaplain for a while during the war. I didn't know that. With the Navy, only a year. I was recalled. I didn't seem able to talk to the men when they needed it. Oh, I... I talked, but... they weren't interested. Where did you serve? In the Pacific. I was at Okinawa. A boy died while I was talking to him, a Marine. Did he hurt me? Sure he did. You just tell them the same things. That dying is the only door to eternal salvation. That life is just one phase. That God is waiting for us, and death is the road we must travel to reach him. Yeah, I know. You know, the hardest thing about this, even harder than leaving Eleanor and Jimmy for knowing I'll never see it snow again or so many things I'll never see again. Even harder is the fact that I can't get used to the idea that it's going to happen. That I...  I just don't think it's possible. You know what I think it is, that feeling? No. Well, I have it. I think everyone I've ever met has it. It's always seemed to me to be an intimation of immortality. Or wishful thinking. No, no. I don't think so. Because it always seems most pronounced in the very young, or the very old. And they certainly don't have much in common as far as outlook goes, or in any wishful thinking they might do. They're poles apart. As you may have noticed, as groups, the very young and the very old are completely intolerant of one another. Well, how do you explain they're both having this... this feeling of immortality so much more strongly than the rest of us? Well, it's... it's just a theory. But I think it has something to do with their closeness to God. How do you mean? The very young, I so to speak, fresh from his hands. He's just created them. And the old ones are almost throughliving and on their way back to him. I think it may be that nearness to the Almighty they both have at opposite ends of the life cycle that gives them the common feeling. Yeah, then... Oh, why have I got it? I'm no kid, but I'm not an old man, either. No, but you're almost throughliving. Yeah, yeah. I am at that. I think you should tell Eleanor, James. Yeah, I suppose so. I could be wrong, but... as I see it, she is a right to know. No, you're not wrong, Father. You know, that Marine you said you talked to at Okinawa? Yes. I don't know whether he heard you or not, but... if he didn't, he really missed something. I didn't think I'd be able to do it. Tell Eleanor. We went home and had dinner, and that afternoon Jimmy went swimming, and I tried to do it then. I knew I couldn't stall much longer. Dr. Weldon had told me that in a week, two at the most, pain would get so bad I'd have to sweat the last of it out in the hospital. But about 15 minutes after Jimmy left the house, Stu Johnson and his wife dropped in. They were still there when he came home. We had nice supper, cold cuts and cheese, and Stu went out for some beer. They didn't leave until almost 10 o'clock. Then suddenly, Eleanor and I were alone for the first time that day. I'm unconscious. Want me to help you clean up? No, I'll do it in the morning. You just put on blinders when you walk through here for breakfast tomorrow. Okay. See, let's, uh... let's sit down for a minute, huh? I, uh... I want to tell you something. Is anything wrong, Jim? Yeah. Yes, something's wrong. It started a week ago. You know that night when I thought I had the toothache? We sat there on the couch as we had before, a thousand times. After the company had left her, Jim was fast asleep upstairs. On nights when we'd made plans for the future, where we'd spend our vacation that year, or what color of a new rug should be in the dining room, we sat there and I told her what was going to happen. I think she'd half guessed it two nights before, but that didn't make things any easier for either of us. I tried to be business-like about someone, telling her about the insurance and the tax forms and the whatnot, but then I tried to be philosophical. After all, it happened to everybody. It had to happen sometime. And then, almost in desperation, I told her what Father Hughes had said to me that afternoon and how much better it had made me feel. Eleanor hardly said anything. Once in a while, she'd nod or look at me, and I'd see her eyes were moist. She barely said a word. It was almost 1.30 when we went to bed. I lay there in the dark, waiting for her to hit her, waiting for the reaction to set in. I could tell she was awake because every so often she'd exhale heavily as if she'd been holding a breath for a long time, then finally, or it must have been two hours later, as I could see the edge of the sky over the heaves slowly getting gray. She twisted around in bed and took my hand, not as much as I was. Father Hughes is right, Janune. Nobody really dies. Does Dr. Weldon really think they can fix it up about the pain? Yeah, I won't feel a thing. I'll be good, Jim. I won't disappoint you. You never have. Jim, there isn't any time in eternity is there? No, that's what they tell me. Well, then we really won't have to wait much at all to see each other again. I guess that's right. Will it make you feel worse if I cry? I don't know. I don't think so. It's just like when you used to go fishing with Stu and the others and the wives weren't invited. Yeah, there wasn't any room in the boat. It just made me feel bad that I couldn't go along, so once in a while I cried about it. I didn't know that. Why wait till you were gone? Sometimes the night before, till you were asleep. Time is it? Almost four. You can still get a few hours rest if you try. I'll try. I've got a big day tomorrow. Close your eyes, Jim. They're closed. Sleep tight, darling. This is Ruth Hussie again. We all know from bitter experience that there's no such thing as a real bargain. There are no giveaway shows in life. We get only what we pay for. Now, this is especially true of family life. Life in some families is a rich, rewarding, happy experience. And life in other families is a cold, lonely, almost dismal existence. And what makes the difference is how much we're willing to pay for our family happiness. If we're stingy and do only just what we have to do and help out only when we must, love only as much as we should, well, maybe we have a quiet house, but we don't have a really happy home. Real happiness is like anything else that's really good. It's expensive. Real family happiness is much more expensive than we would normally imagine. It costs a great deal. Sometimes it costs us an extra nod of approval or an extra helping hand or even only an extra smile. These are the things that make a house really a home. A group of people, really a family. But these are the things that are really hard, really expensive. These are the things that can only come with family prayer. But when we pray together as a family, we invest in the real means of family happiness. We suddenly find that we have more room in our lives for one another because as a family, we've made room in our lives together for him. So when you pray, pray together as a family for the family that prays together, stays together.  But Family Theatre has brought you transcribed big days starring Stephen McNally. Ruth Hussey was your hostess. Others in our cast were Lillian Bayeth, Tudor Owen, Jack Krushen, John Stevenson, and Jack Carroll. The script was written and directed by John T. Kelly with music composed and conducted by Harry Zimmerman. This series of Family Theatre broadcasts is made possible by the thousands of you who feel the need for this type of program. By the Mutual Network, which has responded to this need. And by the hundreds of stars of stage, screen, and radio who give so unselfishly their time and talent to appear on our Family Theatre stage.  This is Tony Lofrano expressing the wish of Family Theatre God may be upon you and your home. And inviting you to join us next week when Family Theatre will present the outing starring Jack Haley. Loretta Young will be your hostess. Join us, won't you? Family Theatre has broadcast throughout the world and originates in the Hollywood studios of the world's largest network. This is Mutual, the radio network for all America.


So, so thank you. I will give you a warning at the start. I'm not a clinician. I don't pretend to be a clinician I'm married to a clinician. She yells at me when I say things that are completely and utterly ridiculous And I honestly hope that nothing that I say today will deserve that treatment Yes Good good, that's that's important. All right. Is that better is it turned on? Okay Right, so I I'm going to give my very simple thought simplified view of what we have here The dramatically simplified clinical workflow and then what I'm going to focus on so the first part identify variants It's of course technically easy and getting easier Use what we already know to make sense of them. This is about the best we can do right now And what we already know includes previous studies Algorithmic things basically use what we know to make sense of them and then do something about it This is the part that I'm definitely not involved with but this center part use what we already know to make some sense of them is Where I think the database integration and the types of resources we have at the EBI can be useful So to put this into a little bit Finer point to go from research understanding of human variation to using it in more standard medical practice I think we need a few things and this is again My perspective from from sitting on top of a number of very large databases We need consistent traceable data generation and analysis routines. We simply have to know what we have done Robust annotation based on public information sources such as those that we have at the EBI or the NCBI I Think it's probably true that about 95% of all the information that could be used to understand and interpret human variation is Already in the public domain. This is existing information obviously as we generate more this number will go down I've been saying this for a while. Nobody challenges this this percentage. So I just keep saying it and And then of course we need to report some of this information into medical records so that it can be used So I'm going to start I'm going to talk about two things In the under this concept of database integration One is the idea of continually updating and update the existing information to ensure that it's accurate and comprehensive And I'm just going to start on some of the ways that we do this in the research setting We have a database at the EBI. It's called the European genome phenome archive This is a secure database. It stores the results of data generated from research into molecular medicine This is what the home page looks like we organize the data by study by data sets by data providers This turns out to be useful distinctions as very large data sets are often used in multiple studies and people who create data sets often create multiple data sets Just rather than look at the home page. Here's some text about it. The EGA is a for secure storage We provide authorized access to all types of data sets that get generated in the context of of research into Molecular medicine DNA sequence genotypes transcriptomics phenotype data We currently have data associated with GWAS studies cancer studies The human epigenome consortium UK 10k and many other smaller scale projects We are the peer archive so to speak of the DB gap database at the NCBI For legal reasons and restrictions. We don't exchange the data that's in the databases between the EGA and And DB gap, but we have exchanged metadata So if you go to the EGA and search for a study that's available in DB gap You'll actually find it and you'll find that it's available in DB gap and vice versa If you go to DB gap and search for something like the welcome trust case control consortium You'll find that we have it and a link to how to get it so besides storing that sort of data this data that's generated in the context of Doing research into molecular medicine. We are accumulating a tremendous amount of data on the human genome sequence to understand what it's doing These include projects that the NHGRI funds like in code, but they're coming from all sorts of different projects We integrate this together Into the ensemble genome browser. It's how we provide information on the human genome and annotation We think the types of things that we have there are useful for understanding what the genome is doing This is just some example of some of the things that we have from Alignments where we have regions of evolutionary constraint to genes and gene families and so on Within ensemble we've pulled in a lot of different data sources That are human variation data not only do we bring in the polymorphism data from DB snip And try to separate that into things that are coming from thousand genomes or other places We've been bringing in locust specific data from locust specific databases Using a standard sequence that we've developed and continue to develop in collaboration with the NCBI and other people We have structural polymorphism data mutation data from cosmic and htmd as well as phenotype data from a number of sources and the types of raw materials people use in their research So this just gives some numbers right now. There's you know, as you know, there's around 20,000 20,000 genes we have the information on somewhere around a hundred thousand variants some of these of course overlap And all of this data is is there we update it continuously with each release This is still a tiny fraction of the variants that are available in the genome and that number is now touching something like 45 million Going from I mentioned this a little bit already going from lsdb's or even diagnostic labs to the type of central resources We've worked to try to break down the informatics barriers to doing this breaking down the informatics barriers does not solve the problems here There are many other barriers including the ease at which one can do this Aspects of intellectual property whether or not people are willing to share But we have worked to bring down the informatics barriers And and like I said, we have done this in collaboration with NCBI and with other groups So part two Provide a method to search the relevant resources using variants or eventually hold genomes as inputs So we can collect data together and in fact we've already heard this morning that people are collecting data together to make their own interpretations Searching through this and searching through the most up-to-date thing Is something that will continue to be a problem? Google is a valuable resource searching Google with a chromosome coordinate and the letter a it doesn't return anything useful At least not usually One of the ways we've done this is through something that we called the variant effect prediction tool or the VAP What this does is takes in individual sites of variant variation in the genome and does a number of things One it calculates the effect of the snips in the context of the ensemble genes and regulatory features We provide this with a web interface with a more standard computer interface that people could put into a pipeline We've put it back towards the previous version of the human genome We're working right now. It doesn't do structural variants very effectively But we're working to increase that functionality especially in the context of ICGC And bringing in information that we find in projects like encode to understand when the variants are disrupting known transcription factor binding sites We've created the ability to run this without connecting to the internet. So it doesn't have to break security and we have We've now written the code in our in the process of testing it for user to find plug-ins So people can do all sorts of very creative things And finally we we plan to start in 2012 just returning the answer as to whether a variant is seen in an EGA data set So within behind the protected wall and then tell people how to apply to get more information about that So this is effectively a variant-based search of VBI's data resources And we would like to make this even more comprehensive as a variant-based search of VBI's data resources So I'm going to give you some examples on how this works in practice just to show you what I mean At present we bring in all the information that we have in various ensemble databases That in and of itself is a hub of information that we pull in from a lot of other EBI resources And we do this in a way that we've we've written a whole host of code now It's very modularized and provide the results through the web browser This is an example of the the way the web interface works right now the types of things we return Because we could do this it runs generally across all species Human is where it's used the most, but we actually have a lot of people doing farm animal research that like to do this And of course, there's a lot of profit involved in that We support multiple data formats And Importantly and I'll come on to this a little bit. We return Information using standardized terms so that everyone ideally understands what we're talking about We provide Co-location with existing variants so whether or not it already exists in DB snip is this a thousand genomes variant and so on We can return information in standard nomenclature like hgvs We have pre-calculated sift polyphen and condel across the entire genome for every possible amino acid substitution Although I think there are questions as to the validity of this. I can tell you from the usage standpoint This is incredibly popular people use this constantly And the ability to filter against hat map or thousand genomes frequency data as well So this is the way the output comes. It's really a very simple form It actually goes quite a long way across the page. You can see it's kind of blurred out on the side I think I can show you sort of the rest of it where we go across and provide a whole host of information Using the command line version. This can be customized in a very considerable way. I Mentioned already the importance of talking about things in standardized terms It turns out that even very simple things and one of the points that I want to make here is that Everyone knows the uncertainty In this process very close to them But they think other parts of the process are much more certain than they are Almost every part of the process is filled with uncertainty. So for example, if you return that a variant disrupts a splice site You might not be talking about the same thing if you talk to two other to two people Splice sites mean different things to different people even very simple things like that So we've worked with the sequence ontology group So when we actually say a variant disrupts a splice donor It has a defined meeting and we've worked with NCBI. So when they say it disrupts us the place donor It has the same meaning. This is actually these kind of small things can be important to advancements Especially as you try to combine data across larger domains This is what our sift and polyphen matrix looks like like I said We've calculated it for every possible amino acid change in the human genome and this is actually a very popular resource Regulatory region consequences Especially with the observation that GWAS data appears very commonly in non-coding regions of the genome The encode project has identified and been able to annotate many of those Those associated SNPs With with regulatory region disruptions or apparent ones So we've gone through an incorporating data from the encode project To return whether a variant exists in a regulatory region whether it exists in an identified transcription factor binding motif and even whether it exists in a highly informative position within that motif So you can know if your variant hits for example that great big C in the middle or one of those tiny little ACs over on the side and that might be important for you to make some decision So this comes down to our ability to answer kind of this relatively simple question Has this variant ever been seen before I think it's actually becoming one of the most common Maybe one of the most important questions in human genomics, but it's actually incredibly difficult to answer Most people who are trying to answer this are collecting all the data that they can themselves to try to answer this question so if you go back to to the thousand genomes issue of nature back in October 2010 Nature said that there was about 2700 genomes. They said there would be 30,000 by the end of 2011 I have no idea how close we are to this number But I do know that it's very difficult to get your hands on any large number of genomes if you want to use them as Any sensible control It's also true for exomes and even the data under controlled access is challenging to get as any of you who have ever tried To do so will know So just a couple of thoughts on the future. I want to make it very clear ensemble is not a clinical decision support tool And only a fraction of the important resources that we can access with it have really been presented today But I do think that some of the things we're doing shows the way forward the data is comprehensive It's versioned so you know what you what you're looking at when you looked at it when we created it standardized we used controlled terminology we updated regularly we have both evidence-based and Algorithmic aspects to it. We're fully open all the data can be taken and used And and to finally say this one more time There's uncertainty at every step in the process of the genome reference is uncertain The gene set is uncertain. There is no such thing as a single human gene set And so while we all recognize the little areas of uncertainty It's important to recognize that everything is uncertain and we just have to make the best possible decisions given that and so just to acknowledge the people that that actually do all of this as well as the people who Pay for me to go to work every day and get it done Yeah But and the question is what's the what what is our denominator here because is your denominator? 95% could be used. Yeah, your denominator there must be Information that is generated and is either publicly accessible or is not publicly accessible correct so essentially that's true if if one has a a variant of unknown significance for example It's I think it's true that about if you were to completely go and track that down Given only the variant about 95% of the information you would use to do that which might be let's say a crystallized protein structure or might be whether or not Whether or not that has been observed in in other populations. I think that's available in the public domain I don't think there are as large-scale private sources of that information I would say 95% of the information that could be used to interpret the variants that I'm finding doesn't exist anywhere So so so actually so I'm making a very different point. I'm not talking about the information to solve the problem I'm talking about the information that exists that could be used. Yes. Yes. Yes I agree completely the information required to solve the problem is dramatically missing