Hey everyone and welcome back to a brand new Backrooms Level Explanation on the channel. I'm your host, Brookly, the Backrooms YouTuber. I love how I say that every video as if someone else is going to be talking. Today I'm going to be talking about Backrooms Level 4,000. A.k.a. the Final Frontier. This level is from Over on the Fandom and it's pretty scary. Especially if you don't like water. So let's dive right into it. Yeah, that's what I did there. Level 4,000, a.k.a. the Final Frontier, is extremely unsecure and unsafe for the most part. Except in one part, which I'll talk about later. And the level is split up into two distinct sections, which I'll be explaining in depth of course. But the two sections are called Thelacophobia and the Near Shore Area. The Thelacophobia Area is unsafe and unsecure and has undocumented entities around as well as an extremely dangerous documented one. But this part of the level induces a deep sense of Thelacophobia to you the second you're in it. Even if you don't have that to begin with, it still gives it to you. Which is just terrifying, man. Also if you don't know what it is, Thelacophobia is the fear of underneath of water, the things underneath of it. This area has another weird effect on you where it drains your sanity constantly and you can't even help it. It just happens. This section also has extremely deep, dark water and the sky is always gray with no sun and the water is always rough and choppy. The only confirmed entity here is called the Death Whale. Which pretty much sounds exactly like the name suggests and is exactly like the name suggests. But I'll explain it in detail in the entity section of the video so be patient. But yeah, that's it for the Thelacophobia section of the level. It's dangerous, it's deep, it's a dark ocean. What else is there to say? The next section is called the Near Shore Area and this area is actually pretty safe and moderately secure. Which is way better than the Death Whale infested water. Since its name is literally near shore, I'm sure you can guess that this section is near a shoreline quote unquote. But don't get your hopes up because there is no actual shoreline. It's just an infinite section of an area that looks like it's gonna be a shoreline but you can never get close to it.  Apparently two Meg members traveled 26 miles towards the shore that they thought was a shore and they didn't get any closer. This area has these black rock island formation things that stick out of the water and there's lots of other sea life here as well. Like birds and lizards and that kind of stuff. As well as seagulls and mackerels and other fish and you know just the typical ocean stuff. And a really creepy entity also lives here called La Camiloa. Which I'm gonna talk about in depth in the entity section so you'll see it there. Every four hours in this area a random mist will start to roll over the water. And off in the distance you'll see a lighthouse light and the tower very faintly. But it's impossible to get to this lighthouse because it seems to change directions. And after about five hours of this mist in this lighthouse, it'll all disappear and it'll all be gone. And that was the last part of the le- wait there's a secret part what? The secret part of level 4000 is called the silver waters and is safe secure with no entities. This section of the level has only been seen by two people ever and the entrance to it is unconfirmed and obviously unsafe. The water in the section of the level is kind of metallic it has this weird thick texture to it. And it's also been tested and is actually made of a very similar compound to liquid silver. So like melted silver but an ocean. Interesting very interesting. So for the long-awaited entity section there are two main ones that I want to talk about. And those are the Death Whales and then the La Camiloa. We'll get into the Death Whales first. These things look like normal humpback whales which if you didn't know are already one of the largest things on planet Earth. So that's terrifying. But instead of the peaceful giants from real life, Death Whales are anything but that. They are dangerous. They can detect you from miles away when you're in the water and they can swim straight up towards you.  The only chance of survival you have is to swim away just in time to dodge them. They also sometimes just come out of the water and just sit there with their mouth open for a little bit. Almost like they're drinking oxygen. I don't know. It's different from real life whales because obviously real life whales have air through a blowhole. So maybe these things don't have a blowhole and they just breathe through their mouth. So far there's been a total of 56 victims of these Death Whales and the number will probably keep going up as more and more people go to this level. The next entity is the La Camiloa entity, which is just terrifying to look at. I mean, just look. This creature is very mysterious and is rarely seen, but it's really unknown how it's supposed to act because sometimes it's aggressive, but most of the time it's not. It looks like a large humanoid that's made out of stone and it's supposed to be around 100 feet tall, but that's just how tall it is when it stands out of the water. Like imagine how tall it actually is with its feet touching the bottom of the ocean. It's got to be like 20 miles tall. The creature has only actually underlived two humans total by accidentally dragging them down underwater, but apparently it's kind of friendly to humans and doesn't actually seek out to attack them like someone else we know. But yeah, a four mile tall stone humanoid creature is still terrifying. There are actually two colonies on this level. Those are the Ocean Explorers and the Noki Noki. The Ocean Explorers, well, they're Ocean Explorers and they're the only official group stationed here. They live on a huge inflatable raft on the water and they guide wanderers to the exit of the level. Kind of wholesome. And they also like to swim, which is also wholesome. Now the Noki Noki tribe is a tribe of 50 people who live on one of those rock outcropping island things and they seem to be like a hunter-gatherer society that just hunts animals in the near shore area. They're moderately hostile to outsiders but can be bargained with if you don't get really aggressive. To enter this level, the only reliable way is to no-clip through a wet spot in the carpet in level zero. The rest of them are unreliable and are kind of finicky. Now to exit this level, you can find a specific circle of rock formations and then just wait on top of them to be teleported to the hub. Or in extremely rare occasions, you can see the shore that I was talking about earlier but the shore has a city on it when you see it and then you can swim towards it and then you'll be in level 1976. But that's extremely rare. The other two exits almost never happen or never work, so don't even try. And yeah, that was it for level 4000. An ocean level cut into a couple parts with death whales and a giant stone humanoid that randomly walks around. Sounds pretty fun to me. Hope you all enjoyed this level explanation. Thank you for watching to the end of the video. I appreciate it a ton. Make sure you check out the description for any links you might want to my socials, my second channel. Tugli, which I've been uploading on recently. I'm uploading a skinwalker encounter story time that I had today. Go watch it. Certified banger for real. Think you'll love it. Comment on this video, death whales is scary. If you've watched to this point, because if you comment that, you're just awesome. I mean, what else can I say? Thank you for the supports on everything. Y'all are so cool for real. I love you. Thank you so much for everything. I have so much planned for the summer. I'll be talking a little bit more about it as the videos come out more and more. But the burglary summer spectacular is going to happen. More fan made levels, more survival guides is going to be just awesome. Thank you for watching. Peace out.


Okay. Good morning everybody. I'm Fuki Hisama from the Division of Medical Genetics at UW and I'm very pleased to be here. My job today is to talk to you about the genetics of kidney cancer. So this is a brief overview of my talk. Today I'm going to give you a little bit of background about my field, which is medical genetics. When I moved to Seattle eight years ago, I met my neighbors across the street and they asked me what I do and I said I'm a geneticist and I said I'm a doctor and then they said what kind of a doctor and I said I'm a geneticist and they said oh you're not a real doctor then. So I think what they were thinking is that all geneticists do research but I actually do have a license to practice medicine in two states and I see patients every week so I think I am a real doctor. So I'm also going to go over when should a kidney cancer patient be referred to see a genetics provider. I'm going to tell you about some of the known hereditary causes of kidney cancer today and then just at the end for a few minutes I'll touch briefly on direct to consumer genetic testing because this is a very popular question. So the field of genetics basically is the study of heredity and seeks to explain the basis of individual variation that you see in the room as you look around and also variation among different animal species. So medical genetics is a clinical specialty of medicine that deals with genetically influenced variation that is pertinent to human health and disease and so there are over 20,000 genetic disorders and in the slide here you can see going from left to right two children who have progeria or Hutchinson-Gilford syndrome where small children become prematurely aged and frequently die of heart attacks or strokes at the age of 10 or 12. In the middle is a little girl who has chromosome aneuploidy condition that many of you have probably heard of down syndrome caused by having an extra copy of chromosome number 21 and on the right is a little boy who has albinism which is a disorder hereditary disorder of pigmentation where people make less melanin. So as far as genetics healthcare providers I am a medical geneticist and the director of the clinic at UW and the SCCA and a medical geneticist is a physician who has gone on to do specialty training in the field of medical genetics which includes the diagnosis, treatment and management of inherited conditions. We work closely with genetic counselors and so a genetic counselor is a person who has a master's level degree and specializes in the medical genetic and also the psychosocial effects of having a genetic condition in the family. When you come to my clinic, medical genetics clinic visit, there's often a lot of preparation both from our side and from the patient side so I just want to let you know that should you come to our clinic. We need to review the medical history, the family history, often do a physical examination but frequently we ask for medical records for family members because if the person who's affected is not yourself but your family member we do want to look closely at those records to make sure that we are on the same page. So medical genetics is traditionally been thought of as a field of pediatrics and perhaps prenatal or reproductive medicine but it's increasingly recognized in the past 10 or 15 years to be important in adult patients and adult medicine. So I put here a couple of examples, famous examples that you may be familiar with. So first is Angelina Jolie who was very public and written about in the New York Times as far as her decision to disclose that she was at risk for her auditory breast and ovarian cancer and went through genetic testing and was found to carry a BRCAG mutation. Hank Gathers, the basketball player, died suddenly and unexpectedly from a genetic condition that affects about one in five hundred people called hypertrophic cardiomyopathy. And this is frequently the cause of sudden death in athletes on the field of sports. And on the right you may not know him by name but J. Monahan was actually, what was her name? Yes, Katie Courix husband, thank you. And J. Monahan died unfortunately at a young age from colon cancer which is caused by inherited condition called Lynch syndrome. So this is basically the statistics for our clinic at the University of Washington. Our clinic actually started in 1959 and was founded by Dr. Arno Matulski who's the founding division head of medical genetics here in Seattle. So you can see that we have exceeded 2500 patient visits per year and about half of the patients that we see now or over 1000 patients a year are seen for a cancer genetic indication. I love this photo from 1962 so you can see Dr. Matulski is sitting here and this is the clinic conference and they actually just brought the patient into the room and they all met with him simultaneously. So this is the current staff of our clinic and again the largest group of patients that we serve is patients with cancer genetic indications. We also see patients with cardiovascular genetic conditions, neuro genetic conditions and basically any other inherited condition that can present in adults. We are unique in that we are the only medical system in the state of Washington that has the physicians who specialize in the care of adults with genetic conditions and five of our physicians have been named in Seattle Magazine or Seattle Metropolitan Magazine as top doctors in their field including me. So if you happen to have a copy of the February 2016 Seattle Magazine lying around then you can read a little bit more about me and my career. So to get to the topic for today we know that cancer is common and unfortunately affects between one in two and one in three people in their lifetime and it's estimated that about five to ten percent of all cancers are strongly hereditary. What I mean by that is that you are born with a mutation in a gene typically a tumor suppressor gene that protects you from developing cancer. We have two copies of every gene so if you have a mutation in one of the two copies you've lost half of the natural protection from that gene and that means that over a lifetime you're more likely to develop the cancers that are associated with loss of function of that gene. Hereditary cancer conditions increase the risk for well-known common cancers such as breast cancer and colon cancer and hereditary cancer conditions can also include very rare cancers such as adrenal cortical carcinoma or retinoblastoma which is a childhood eye cancer. So what I do a lot of the time is take a family history and talk to people about medical conditions in their family so why do we do this why do we spend the time which can frequently be extensive and also obtaining medical records for family members why do we take a family history and look specifically for a genetic predisposition so this is an example from colorectal cancer and what you can see here is that the red line at the bottom is the baseline or population risk to develop colon cancer starting from age 20 to age 70 so you can see that the risk rises slowly with age and overall about six percent of people will develop colon cancer in their lifetime contrast that with these two well-known hereditary colon cancer conditions so this stands for hereditary non-polyposis colon cancer or Lynch syndrome and so the lifetime risk of colon cancer by about age 70 is about 50 percent okay and the risk to develop familial adenomatous polyposis actually I would say it's closer to a hundred percent okay so the idea is what we would like to do with these individuals is to identify them before they develop colon cancer okay through genetic evaluation and testing and then to prevent them from developing colon cancer with surgery or with screening particularly with Lynch syndrome there's often a long phase where patients have tubular adenomas or pre-cancerous polyps and if they can be removed before they become cancerous then that person may never develop the cancer associated with this condition so is there a hereditary cancer condition in your family again remember that most cancers are sporadic meaning not strongly genetic and are caused by some of the risk factors that Dr. Taikodi brought up so clues to the presence of a hereditary cancer condition in the family include things like a cancer diagnosed prior to the age of 50 okay and again this is a rule of thumb it's not an absolute rule having the same or genetically related cancers in multiple generations so if there are two generations in the family who've both had kidney cancer or three generations we at least ask the question or start to become concerned that there could be a hereditary basis for those cancers there are some cancers that are genetically related such as colon cancer and uterine cancer and again if we see these patterns in the family then we think about particular genetic predispositions another rule is having primary cancers impaired organs so a woman who has bilateral breast cancer or a woman or man who has bilateral renal cancer is more likely to have a underlying again genetic predisposition to have developed that cancer and then finally individuals who have certain types of rare cancers such as any man who develops breast cancer we consider whether he had a genetic predisposition to develop that and that again is some caused by some of the same genes as that cause early onset breast cancer in women but additionally some other genetic causes that don't that do not affect women so I have the same slide as Dr. Tycote so I feel good about that that we have the same information so there are almost 63,000 new cases of kidney cancer diagnosed in 2016 so five percent of those would be estimated to have a genetic cause so about 2,500 cases of kidney cancer per year would have a strongly genetic basis and this is a list of some of the hereditary or genetic kidney cancer syndromes I'll give you just a minute to absorb these okay but rather than just sort of giving you all of these rare diseases and rare names of things that are very difficult to to recall I thought actually it might be helpful to just share with you a couple of the patients that I've seen so the first case is a 37 year old woman who had shortness of breath night sweats and noticed a mass in her neck and so she underwent a lymph node biopsy which showed a carcinoma with that was consistent with a primary papillary renal cancer so her past medical history was significant actually for having fibroids when she was very young so fibroids of course are extremely common in the population but they typically happen at older ages so the fact that she had fibroids in her severe fibroids in her 20s to the extent that she actually had surgery for it is unusual her family history is notable for having two children four brothers and her mother in her 70s also had fibroids with an early hysterectomy but has had no cancer diagnosis and her father died in his 50s of heart disease so what I thought of for her is actually a genetic condition called hereditary liomyomatosis and renal cell cancer or reed reed syndrome and it has three major features so the first one is having actually fibroids on the skin okay which you can sometimes see on physical examination the second feature is uterine fibroids in women and these are like the regular fibroids that women develop but they happen at younger ages and they tend to be multiple and severe and the third feature is renal cancer so the combination of early fibroids in herself and her mother and the type of renal cancer that she had made me consider this condition for this woman so this basically just goes over some of a little bit more detail of the cutaneous liomyomas or fibroids the uterine fibroids and the renal tumors and notice that not everyone with this condition develops kidney cancer so only about 10 to 15 percent of people who have reed syndrome develop kidney cancer and it typically happens at a younger age so again following that rule that inherited cancers tend to affect people at younger ages than sporadic cancers so there are screening recommendations for this condition and we know that reed syndrome is caused by mutations in the fumarate hydratase gene so genetic test results I will let you know are not always positive or negative any genetic tests can come back as positive negative or uncertain and so when we sent testing for this patient she actually did have that third category of genetic result so it was not a definitive result but she had a substitution of one protein building block called arginine for the normal protein building block called glycine at position number 97 so the difficulty that I have as a geneticist with this particular result is that I very strongly suspect clinically that this is the disease that she has however because we're not absolutely certain about the significance of the genetic test result I would not want to use this in a predictive way to test unaffected family members and to make irreversible that is for example surgical decisions we did counsel her family that we do consider them to be at higher risk and that they should undergo screening for kidney cancer and evaluation for the skin findings the second case is a young man who was sent to my clinic for overgrowth so the reason that that's considered to be potentially a genetic condition is that people who are very big and large there and there are a number of described genetic overgrowth syndromes some of them are associated with increased risk of cancers and so that's what this young man was sent for so he was six foot eight he weighed 247 pounds and when I measured his head circumference it was 65 centimeters and again 60 centimeters is almost at the top of the curve in terms of being very large so I had them stand next to one of the genetic counselors in our clinic robin benefit there on the left so you get a little perspective and then on the right you can see my shoe size which is seven compared to his shoe size which is 16 and a half okay so when it turns out when he had been six years old he was actually evaluated for overgrowth he was already big at that time and the parents were told when he was six years old that he might have a different overgrowth condition called pso do syndrome but at the time there was no genetic testing available to confirm or exclude that one of the features of pso do syndrome is advanced bone age so he did have a bone age x-ray which was normal in the meantime from then until the time I had seen him seen him he had actually developed some paupules or growth on his gums which were removed because they were bothering him and they were consistent with hammer tomas which is a benign kind of tumor but that actually gave me potentially a clue to what the diagnosis was that he actually has when we're talking about things like height and weight it is important to consider the family background and his parents his father and his sister are both quite tall actually oops okay so I'm sorry this is so blurry but I took a picture of his tongue because he also had some of these paupules on his tongue here so little extra bumps and so I considered that he had a genetic condition called cowden syndrome also known as pp10 hammer coma syndrome because they have various types of hammer tomas as well as overgrowth including characteristically a very large head size and so his results were positive for a single base deletion that results in a what we call a premature termination codon so basically typically you start at the beginning of a gene you read through to the end stop reading and then you produce a full length protein in this case what this causes is a shift in the reading frame and so basically the protein gets chopped off earlier than expected so this is clearly a disease causing mutation and consistent with the diagnosis of cowden syndrome in him so once we identify a mutation in a family like in this young man we can test their relatives to find out who is at risk and then offer them appropriate screening and who is not at risk and then they wouldn't need to go on and have more screening so the first woman that I mentioned we would recommend continued screening for all of her close family members because we don't we can't tell through genetic testing who is and who's not at risk in this case we could offer testing to his sister and other family members and see who does not need to have screening for cowden syndrome so these are the major and minor criteria for cowden syndrome for the aficionados in the audience and then these are the cancer risks that are specifically associated with cowden syndrome so notice that there is a significant lifetime risk of kidney cancer but importantly it's not the only cancer risk associated with cowden syndrome and in fact we do consider this to be a breast cancer risk condition as well the thyroid cancer risk is high enough that routine screening for thyroid cancer by physical examination and thyroid ultrasound is recommended and there are some other associated risks there as well so some of you have probably seen president obama's address in which he talked about precision medicine and how do we turn the science of genetics into actual medical therapies so one of the things that we can do is basically we can change someone's care quite soon after we make a genetic diagnosis so these are specific recommendations for the management of individuals who have been confirmed to have cowden syndrome so for example for women it changes when and how often they start to have mammography women should consider having endometrial biopsies or ultrasound for the risk of endometrial or uterine cancer as I mentioned annual thyroid ultrasound is recommended colonoscopy screening is recommended to begin 15 years earlier and then routine screening for the kidney cancer risk as well beginning at age 40 the last case that I'll present to you today is a 35 year old man who came to our clinic because he already knew that he had a genetic condition in his family and so we had seen and evaluated other family other members of his family and he was at risk so in terms of what the medical problems in the family were several family members had presented with something called spontaneous pneumothorax which basically means they part of the lung collapsed and then they have acute shortness of breath and went to the emergency room for that when they went to the emergency room they could treat it but didn't really know what caused it other family other members of his family had had kidney cancer and so he came and we had seen other family members we had the information about what the mutation was in the family and so he came because he was interested in knowing whether he was affected or not so because I already had all of this background information I was very clued in to what he could have and I knew the diagnosis so in meeting him he actually had and it's quite subtle here I don't know if I can turn the lights down at all but he has can I turn down the lights in the front or can you see this he has like little tiny bumps on his forehead I don't know if you can see that or not but because I was looking for them so intensely oh perfect thank you see these little things so these are actually the skin manifestation of the genetic condition that he has okay and so those are called fibro folliculomas and they are a cardinal feature of another genetic condition associated with kidney cancer called burthog duvet syndrome and again individuals who have this have a greatly increased chance to have spontaneous pneumothorax compared with the average person there are other skin findings and importantly of course they have an increased risk for renal tumors which tend to be chromophobic tumors burthog duvet is caused by mutations in a single gene called folliculom and since we knew the mutation in his family we didn't need to go searching through the entire gene we could just go right to the position of the known mutation in his family and give him a clear yes you inherited it or no you did not inherit it kind of an answer because of the nature of burthog duvet syndrome affecting different organ systems they may present to a urologist with a renal tumor or an oncologist because of the kidney cancer again they may be seen first by an emergency room doctor or a pulmonary specialist because of the pneumothorax and a number of patients with burthog duvet actually present to dermatologists because of these skin findings which are benign but which are an important clue to the presence of the underlying genetic condition I will say that had he not had the little skin bumps I still would have offered him genetic testing because a number of patients actually don't have the fibro folliculomans so to summarize in terms of red flags for kidney cancer I think the most important one is someone who's diagnosed with kidney cancer at a younger age has a greater chance to have it because of an inherited genetic reason bilateral kidney cancers again is a clue that increases the chance that there's an underlying genetic reason for the cancers a positive family history for kidney cancers or especially other cancers before the age of 50 pneumothorax that's unexplained and again certain skin finding suggestive of some genetic conditions so in the last few minutes I just want to talk about home DNA testing so about 12 years ago Thai magazine named the home DNA test the invention of the year and they said that from a simple at home test you could find out your risks for many many diseases so fast forward to 2013 and the FDA actually sent a cease and desist order to 23 and me which is the most well known and popular home DNA testing service by this time over a million people have actually ordered and had DNA testing at home where you just spit into a little tube send it in for a while 23 and me was giving reports where they gave they estimated what your risk of certain conditions was and the FDA objected to that so now they no longer provide those reports but they do give you the raw data basically your DNA sequence of the AC's T's and G's and they say you can go look this up yourself as a geneticist I don't recommend this okay both because I think it does take a lot of experience and training to really be able to understand and interpret genetic test results in a medical context and also because I personally and my colleagues in our clinic have seen unfortunate examples where people have misunderstood or misinterpreted genetic test results and that has led to some unfortunate consequences okay so that is the end of my talk no no that's dubs he's the official mascot of UW I've met dubs though happy to go ahead um so okay we should talk come and see me in the clinic excellent question so so that's a good question that applies to I think a lot of people in the audience whereas your particular question we should probably delve into more one-on-one right and my follow-up to that was when you have family members tested are they covered well not only that but can it prevent them from getting insurance coverage because like at the cancer patients I have trouble getting insurance coverage right on melena right yes yes okay excellent questions thank you for that so first of all genetic services usually are covered by insurance um including Medicare and including Medicaid so there's two types of genetic services the first one is the visit and the second one is the testing right so again usually the visit with a doctor the genetic counselor is a covered benefit um insurances differ as to how the extent that they cover genetic testing all insurances will cover some cancer genetic testing typically for the most well recognized and common conditions like breast cancer genetic testing and colon cancer genetic testing for the rarer we get the less likely it is that the insurance company has a pre-existing rule or coverage decision so oftentimes what we need to do especially for rare genetic conditions uh is pre-authorization so where we work with the insurance company and we explain to them why we want to order this testing and what the medical necessity of it is so that's part of the service that we provide um before and after the visit all of the patients that I showed you had clinical genetic testing covered by insurance in terms of family members again that's a very important question so um again if we identify a mutation in the family we can offer site specific um testing to family members which cost one tenth of what the original testing cost is so typically our genetic testing cost between two thousand and five thousand dollars but for a family member who's at risk with a no mutation the cost is more like two hundred and fifty to five hundred dollars um in terms of discrimination there was a federal law that was enacted during uh George W. Bush's administration called the genetic information non-discrimination act which makes it illegal to discriminate against people based on genetic test results or family history um so if you have a diagnosis um it what I want to say is that it's different to in terms of how insurance rates are affected by a diagnosis of cancer versus a genetic being having a positive genetic test result but having no cancer diagnosis so in that latter case they cannot drop you from health insurance or raise your rates based on a genetic test result to see what I'm saying and most insurances would consider it to be um medically necessary in a covered benefit if you're if you have a close relative first or second or third degree relative who has a positive genetic test result because in the long run it's less expensive to prevent cancer than to treat it you're welcome early on in your discussion you you mentioned the uh the gene that actually targets cancer you said if uh and we have two of those genes uh the one who's gone and um we're at a hard risk have they figured out a way where they can actually introduce that gene into a person's system to to actually go after the cancer and and what have the effect of after you've uh been found to have cancer um so uh again just to just to repeat that part of the talk for people who may not remember it so I was explaining that um so there we have genes that do many different things in our bodies right so some of our genes have a natural role as what we call tumor suppressor genes so they exist to protect us from cancer and all of us have those genes so um in general we have two copies of every gene one inherited from mom and one inherited from dad and so for these tumor suppressor genes a person who has a hereditary predisposition to cancer has one normal gene and the second copy of the gene has a mutation in it so that's why they've lost half of that natural protection um from that uh tumor suppressor gene uh what you're talking about is something along the lines of gene therapy where you would restore the function of a gene um I'm sorry but we're not quite there yet okay so that's something to work on for the future definitely and there's certainly there's a lot of um news now about gene editing technology and how you can you know basically with molecular scissors cut out a gene that's not working and replace it with a version of the gene that is working um that's not being done in people yet at this time it's still in development


Welcome to today's day trading recap Friday, October 22nd, Green Day today plus 509. So let's go over these and then I will come back and recap the week for you. On the mighty 90s, took four trades, a winner in Baidu for 150, Microsoft 310, Roblox was a loser for 352, and then DKNG basically a scratch for eight bucks. On the runners, Disney scratch minus 12, Roku plus 460, Amazon minus 460, and then a runner in the micro S&P for plus 405. So let's go with these, go to the mighty 90s first in Baidu. Baidu had this bounce stuff unchanged, had this big push up almost to the highs of day, little pop and volume got short right here and just cut a little down move there for plus 150. Microsoft was plus 310. Let's take a look at Microsoft. Microsoft had this flush here right there early in the morning, got long right here and cut that bounce for plus 310. Roblox was another mighty 90 that did not work out. This thing just did not want to come down even when the market was flushing.   As you can see it basically flat lined the rest of the day. DKNG was basically a scratch. So DKNG started, it was really weak and then kind of consolidated for a while and then it started to flush again. I got some volume spikes. I thought we were going to get a bounce off this pivot but when it pushed below, I was just trying to scratch it. So when it bounced up here, I just cut out and took a scratch on that one. On to the runners, Disney, Dizzy Disney. So in Disney, I was, let's see, oh yeah, runner. So it showed some initial weakness when it bounced up to this key level. I was looking to get short. It started to roll over. I got out of half my position here and then when it bounced up here, I just cut out the last half. So I took a scratch on the trade. Obviously had I held it, it did roll over which was the name of the game on a couple stocks. I'll show you in Amazon as well. But first, Roku. Roku was a nice winner. And in Roku, oh yeah, Roku was my first trade of the day. So right out of the gate had this big volume spike. So when it bounced here, actually I kind of got in before this bar closed somewhere around here and then this thing just flushed down and I got out pretty close. I think I got out at the end of this bar here. So nice trade there. Nice quick trade for plus 460. Amazon was minus 460. So Amazon took it right away. And this was a frustrating one. We were talking about this in the community. I know Chad and some other people were in it as well. But Amazon had this big flush weakness, big spike in volume. So when it bounced back up to yesterday's low, it got short. And I had on these two dips here, I had over 15% profit. But I only did one contract because Amazon is so big and I didn't want to trade big size today. So I was holding for more. I was looking for a flush like this, like this right here. But when it started to push up right here, it literally squeezed me out right at the top, kind of broke above this consolidation area. It looked like it might bounce. So I got out right here and what do you know happened flushed right down like I thought it would. So it's kind of frustrating when you do something and then it squeezes you out right before it does what you thought it was going to do, but that's trading. And then lastly, S&P futures. So the S&Ps were, the market was just feeling really heavy and the Nasdaq was weaker, but a lot of stocks were just really just weak. And so I was watching this, we watched the S&P push up to new highs and then immediately come down as if it was just trying to sucker people in and then fall over. And so when it got back down into the red and bounced right here, I got short looking for a flush lower and that's exactly what happened. So I scaled out, got out of my last one real close to the bottom here. So nice trade there for plus 405. So net net plus 509 on the day. And so if we take a look overall for the week on the runners plus 676 on 22 trades, win rate a little over 54%. And then on the mighty 90s, a little bit in the red didn't trade any on Monday. 15 trades, 60% win rate, but still slightly in the red. So that's my day. That's my week. Hope everybody has a good weekend. We'll be streaming live every day next week. Look forward to seeing you in the live stream room. Talk to you then.


Uh, it's okay if I bring my pick to your facility. We only have care plans in facility. Pick has a three-letter word. A dog, three-letter word, pick dog. It's the same thing. Right. Okay. No, I understand. It's the same thing. We will only board cats and dogs. What if I put dog hair on it? Color it brown or something like that. You will love the pick. He's a name of flying it.  He does another bite. He play with other dogs.  I bring pick in.  Oh, goodness me. He is a dog. I think he is a dog. It sounds like he thinks he's a dog as well. Yeah, he is. He is not a dog. It's like a fish. You have a fish and then you have a bigger fish. Little fish, big fish. They do the same thing. Okay, fair enough.


The senior special assistant to Governor D'Aquabiodo of Oregon State, who was arrested in the United States, has been denied bail. A federal magistrate court sitting in New York ruled on Wednesday that Abidami Rufai cannot be released before his trial. Rufai is facing charges of masterminding a $350,000 employment fraud and could face up to 30 years if convicted. Do subscribe to our YouTube channel and don't forget to hit the notification button so you get notified about fresh news updates.


What's good Josh your boy Ross back again with another video? So we're gonna check out 10 WWE world title reigns that should have lasted longer by none other than Cultaholic wrestling I've been subscribed to them for a few years now So from time to time I do check out their videos, but this will be the first time I believe I will be checking out Their videos on my channel doing a reaction for you guys. So yeah, this should be interesting I can easily think of one right now Bray Wyatt's WWE Title reign should have been much longer than what it was. That's that's just one I can think of off-hand So this should be an interesting video man So let's get right into this appreciate all the love and support Roll to 60k man, and let's do this The WWE title Arguably the biggest prize in professional wrestling The one belt the majority of wrestlers aspire to one-day hold and it's Goldy too Let's not forget WWE's other classic world championship between the pair of them. There have been over 190 reigns We've seen the good the bad and the far too brief And that is what we are looking at today Those title wins that unleashed a wave of euphoria and optimism throughout the WWE fan base Then we're over in the blink of an eye Usually as the status quo was restored. I'm Adam Pachiti from Cultaholic Wrestling and these are 10 WWE championship reigns That should have lasted longer Join us number 10 Bray Wyatt's Bray Wyatt is one of the most I said it I said it I said it before the video even started Bray Wyatt should have had a longer title run and it was cut short by Randy Orton at WrestleMania. It's just It's like they have something good they have something great and WWE will find a way to not capitalize on it They do it every time every single time Who's doubt landish characters in recent memory with a strong aura and presence about him But he is one performer who has suffered more than any other thanks to poor booking and creative in early 2017 The Eater of Worlds was on a tear making the final three of the Royal Rumble then bagging a place in the WWE title elimination Chamber match on the night Bray overcame the likes of AJ Styles John Cena and Dean Ambrose to win the belt setting up a WrestleMania showdown with Rumble winner and Wyatt family brother Randy Orton the two met at Mania in a major misfire of a match more remembered for Kevin Dunne's spooky bollocks insect Projections than any in-ring action making things even worse Orton unnecessarily beats Wyatt to win his umpteenth world title ending the reign at a week 49 days Still, I suppose it could have been worse. He could have lost in three minutes to Goldberg in Saudi Arabia It just doesn't make sense to me. I will never understand WWE's mindset when it came to booking Bray Wyatt I will they would do something that the fans always wanted and then literally they'll take it away Fans wanted him as WWE champion. He finally becomes WWE champion only to lose it to Randy Orton at WrestleMania Why not give him a nice? WrestleMania win That would have been a nice little WrestleMania win that people could have really start buying in the Bray Wyatt even more like Jesus Jeff Hardy Jeff Hardy has always been super popular with a dedicated fan base But that fan base really started to make themselves heard when the charismatic enigma returned to WWE in 2006 after runs in the intercontinental and tag title scenes the company's decision-makers could hardly ignore the Thunderous crowd reactions you received or the mountain of merchandise He shifted as Jeff beat Triple H Armageddon To become the number one contender to Randy Orton's WWE title Orton would retain the title at Royal Rumble 2008 But Jeff would again challenge for the gold this time coming up short against Triple H in a pair of thrillers at No Mercy and Cyber Sunday 2008 Eventually Jeff came up trumps beating Edge and Hunter Armageddon Capping off a year plus of trying to win the big one. It was a joyous scene, but just 40 fantastic moment I believe JR ended up calling One the match that he actually did win It was just dope to see like Jeff Hardy finally getting the WWE championship It was so it was a it was a momentous occasion for sure See two days later at the Royal Rumble Jeff fell in his first major defense losing to Edge in a no-dq match When brother Matt turned on him the bastard number eight I remember that they were going with the Brother versus brother feud at the time and Matt came out there and screwed them over Bill Bryan Daniel Bryan had already shown that he could hold the main title during his 2011 to 2012 World Heavyweight title run But after his popularity exploded in 2013 due to his work in Team Hell No The fans chose Bryan as their guy John Cena agreed and picking Bryan is his opponent at Summer Slam 2013 With the goat beating Cena clean in the main event Unfortunately, though special guest ref triple H helped Randy Orton cash in money in the bank with Brian's reign over in minutes Brian would eventually beat Orton at night of champions to win the title back But only for a day due to a controversial finish Although Brian was eased out of the title picture in favor of Cena Orton and Big Show the super vocal Yes movement ensured that Brian made it to the main event of WrestleMania 30 winning the unified titles on the Grandest stage Sadly though what could have been an epic reign was cut short due to injuries ending it at 65 days Thankfully, he would have a more substantial run four years later number seven edge Propelled by the real-life love triangle with Matt Hardy and Lita Edge became the sleazy must watch rated our superstar and upped his game in every respect WWE realizing his potential booked edge to win the first-ever money in the bank ladder match Which he didn't even want to participate in that edge a heck I want to say I don't know if it was recent, but he had came out saying in an interview That he didn't initially want to be in that match He had to be like kind of I guess you can say convinced to be in that match And it's crazy because him being in that match Changed his career forever If someone hadn't convinced him to be in that match You know, we may not have the edge we have today We may not have the multiple championships like we have today, you know I'm saying so a kudos to that person that did convince him To just go ahead and be in a match because it catapulted his career for sure. No doubt about it WrestleMania 21 Edge carried the briefcase around everywhere But since he was the first person to hold it There was no expectation or clue as to when he would cash it in when he did so on John Cena at New Year's Revolution It was instantly iconic and solidified edge as a true main eventer in the following weeks Edge demonstrated that he could be a ratings draw to as fans tuned into raw in their droves to see what Who he was doing who were it was exciting different and three weeks later It was over a scenery game the title at the Royal Rumble in fact most of edges WWE title reigns were of a transitional nature with the longest of the four clocking in at just 76 days number six big show 2002 started kind of quiet for the big show But his fortunes changed when he was drafted to SmackDown in October making an instant impact by attacking a k-fave Injuring the Undertaker then becoming number one contender to Brock Lesnar's WWE title the next big thing hadn't had the belt for too long at that point and was in the midst of an impressive Undefeated streak so the odds of show unseating him weren't great However, Brock was working with several niggling injuries and WWE gave show the win at Survivor Series turning Lesnar babyface and Paul I know for a fact Dub would be loving this segment right now. He would be Relishing in the fact that Brock a long young Brock Lesnar Lost to the big show at this time. I know Dub He would love this segment of this video for sure Paul Heyman heel in the process a rejuvenated big show running rub shot over the blue brand with Heyman could have been great But 28 days later. He lost the belt to Kurt Angle at Armageddon Nothing was going to stop angle versus Lesnar happening in WrestleMania And show was always going to be a way to get the title to Kurt so that Brock could chase. Yeah It was a shame for Paul White Number five Rob Van Damme You gotta put RVD in there man. I wish his title reign was a little bit longer It should have been longer, bro. Oh man. Gotta put him in gotta put him in the mix I being immensely over and mixing up with top stars like Steve Austin and the Rock in main events WWE were hesitant to book Rob Van Damme above a certain level after his debut in the invasion with Mr Monday night settling into the mid card after recovering from a severe knee injury in 2005 Van Damme returned with a renewed fire winning the second ever money in the Bank ladder match in WrestleMania 21 Before cashing in against John Cena at ECW one night stand to his first world title was worth the wait And on the first episode of ECW on sci-fi Paul Heyman gave RVD the ECW world title to making him a double champ Me weeks later though Van Damme and partner Sabu were arrested on possession charges WWE suspended the champ for 30 days and booked him to drop both titles on the subsequent raw and Wow after years of being overlooked it's unfortunate RVD's sole WWE title run went up in smoke Wow, I never knew that that actually I never knew why He had to drop like drop the title so quickly now it makes sense because of that situation damn man that sucks Because they could have legitimately gave him a nice title run cuz he was over damn man Number four the Undertaker Despite being one of WWE's longest mainstays and beloved characters the Undertaker didn't hold the top prize all too often or for too long Of course the argument could be made that the dead man didn't need to be WWE or world heavyweight champion since his gimmick was so strong and so over and that his general lack of beatability Made it hard to book him as effectively if he held the belt This makes sense because the Undertaker Was one of those characters That honestly he didn't need the belt He actually legitimately didn't need the belt because he was automatically gonna be over and booking them to have the title The only way you could really have him legitimately lose and it kind of keeps his character strong Is if there's like some outside interference because the way they've always booked the Undertaker is like he's not just a normal man He's like more than just you know what you and you and you know you and I are you know saying like he He's supernatural esque and that's how they've always booked him He can take just ridiculous amount of punishment and keep going That's how they booked him So I get why he didn't really need the belt to still be one of the staples in like Wrestling all together in the same way. They really should have booked Bray Wyatt's fiend gimmick They should have booked it like that because him chasing for the title I know this is a little tangent but him chasing for the title against Seth Rollins It wasn't gonna really work in a sense because of how he's booked He's the supernatural character that damn near doesn't sail for any major finisher He can just take punishment over and over and over So when he was going for the title so quickly it kind of you had to throw the belt on him And when they didn't throw the belt on him initially That's when fans backlash characters that have these supernatural abilities and powers in wrestling It's hard to put a title on them because the only way they can legitimately lose is if someone cheats Someone screws them over so At least that's you don't want them to lose clean because then be like what's the point of having these superpowers If you're just gonna lose clean or have this greater You know, then I'm not a human being type persona when you lose clean to someone, you know, and so I get that Of all of his short reigns his world heavyweight title run in 2007 was the most Disappointingly brief he beat Batista in a blockbuster at WrestleMania 23 having won the Royal Rumble match for the privilege at this point in time Taker was lean mean and putting on the matches of his life Regrettably, he soon went down with a torn bicep Necessitating surgery that meant his reign would have to be cut short So WWE engineered a scenario where Edge would cash in his money in the bank briefcase with the phenom dropping the strap after a short 37-day reign Shawn Michaels similar to the case of Big Show we looked at earlier The 2002 Yeah, man, that ah Man that a lemon. I believe that was an elimination chamber that I think that was if I'm not mistaken Correct me if I'm wrong. I think that was the first ever Elimination chamber and he won the title and his title reign was not that long I wish they would have let him out the strap for a little bit, you know a longer time than they did though Viva series only to lose it the next month at Armageddon for HVK though His title win was even more special It was great in the first ever elimination chance at Madison Square Garden Yeah, only his second bout back after him probably returning from a four-year injury layoff WWE gave Michaels the world heavyweight title in a confetti-filled feel-good one of the greatest Like feelings to a pay-per-view ending to a pay-per-view I had seen at that time JR commentary Was it gives me goosebumps just thinking about it, bro The confetti falling it was a beautiful moment and I thought they were gonna really have him hold the title for a while And it was even greater because of the story They were telling between HBK and Triple H because the match he had prior to was against Triple H and he beat him And Triple H tried to storyline wise in you know in his career So when you have this happen and you have him Beat Triple H like actually pinned Triple H for the one two three here And he takes cuz I think Triple H at this time was going in as a champion He takes the title he wins it like it was just a such a good film a feel-good moment And I just I really wish WWE would have Literally like kept this momentum going for Shawn Michaels moments However, it soon became apparent that Michaels was not yet back long-term and that the title reign was tokenistic in nature HBK defended the title one time a disqualification lost to Rob Van Dam on Raw before giving it back to triple H After losing a three stages of hell match a four-week reign with the big gold belt would have been fine Had the showstopper captured another one before his 2010 retirement, but he didn't and this felt like a missed opportunity number two Christian Christians run with the ECW title seemed to be his ceiling until lifelong friend and tag partner Edge was forced to retire whilst World Heavyweight Champion In a bit to move out of Edge's shadow whilst also paying tribute to him Christian beat Alberto Del Rio in a ladder match at Extreme Rules 2011 to win the gold the title win had been a long time coming Worker popular it was definitely something beautiful to see at the time because you know we Christian had been around since it had been around so it was just so good to see that See him capture the gold and a fresh face at the top of the card But then on the very next episode of SmackDown he dropped it to Randy Orton You know the proper star Luckily he won it back a couple of months later at Money in the Bank with Christian and Orton having a tremendous summer series that Elevated not just there. Oh, no that those series of matches between Christian and Randy were fantastic You even started having The roles started switching because Christian started turning heel and Randy started turning face because Christian was His gimmick at that point was one more match. That was his gimmick That was you know, that was his gimmick at that point. It was gonna be just I just need one more match Like it was it was they were having fantastic matches, man Emma but the title itself Christian proved that he could carry the championship and deliver the goods but he didn't get long to enjoy it dropping it back To the Viper 28 days later in another belter at Summerslam. Yep. Number one mankind 1999 was particularly bad for playing hot potato with the WWE title as it flipped back and forth between the likes of Steve Austin the rock the Undertaker and Triple H Mankind got in on the act to lifting the big one on the January 4th episode of Raw in a win that puts a lot of butts in Seats 20 days later and the rock was champion again for a week when mankind got the belt back once again Winning the rating smash halftime heat empty arena bout there during the halftime of the Super Bowl And that lasted for two weeks when the rock once again regained it in a ladder match on Raw There was simply no chance WWE weren't going to go with the rock versus Austin for the title of WrestleMania But it was harsh on the hard-working Foley mankind's third and final WWE title run that year lasted just 24 hours winning the strap and a triple threat match at Summerslam Only to drop it to Triple H the next night on Raw Yeah, man. This is this is one of those scenes where you know Mankind was you know, he was in the era where they had to rock they had stone cold at Triple H They had the Undertaker like those guys in themselves Kurt Angle like those guys in themselves were make it over so and granted mankind was you know the ultimate underdog at that time and It was one of those things where you know, he was over as well. But when it came to Stone Cold and the rock they were at the top of the car like 1a1b some people prefer the rock over stone cold some people prefer stone cold over the rock They were both at the top. So a lot of people wanted to see the titles on them to be honest with you Not to say people didn't love seeing the titles on Mick Foley, but it's just one of those type of things where they Bim being in that time period like a lot of people on the anger on a game And a lot of people were trying to get to the spot where the rock and stone cold was at So but this was a dope video man very interesting I found out some things I didn't know like the RVD situation did not know that so comment down below Let me know any other WWE Champions or world heavyweight champions. Do you feel like they should have had a longer title reign? Let me know down below. I would like to get your thoughts and opinions on that But I appreciate all the love and support row 250k appreciate y'all kicking in with me. I see y'all in the next one. Peace