Hey guys, it's Nate, AKA the Foot Accountant. Welcome back to the channel. Happy Thursday. It's Rival's Rewards Day, of course. And it's about that time of the week again, where we take a look at the cards in packs and say, hey, can we invest in any of these for out-of-packs rises, especially as the content has not been that hot this week. It really is reminding me of the same scenario we had last week with the foot birthday cards from Team 2. There's a lot of good cards in packs that people are interested in. The SPC content has not been as hype, although it's been decent value. It hasn't been that hype as of late, so more of the focus is on the cards in packs. And that could potentially, again, like we saw last week with the foot birthday, lead to some rises out-of-packs. We'll talk about that today, of course. Thursday could be a decent day of content because we had yesterday on Wednesday that it was not very good at all, right? Monday and Wednesday were both days that we would maybe classify as dead or quiet. But then Tuesday, of course, was pretty exciting with the campaign player pick pack, and then potentially today on Thursday they'll bring something else out that will be hype as well. I'm just theorizing in that sense. But Thursdays are usually decent content days. We have some new pack codes to look at. I don't know if they're dropping today, but some new pack codes have been added. Nothing crazy, just some interesting different types of upgrade packs. And then also we have the potential for upcoming icon moments player SBCs. The first leaks have come out about two players that will be coming out as icon moments SBCs for players, not upgrade packs, but players. Not sure when, but hopefully that time is pretty soon. And that's exciting because that's going to take us into a part of the year where a lot of people will be doing icon SBCs to get those moments versions, the best versions of icons through an SBC. So that's everything. We're going to cover the video today. Of course, it's rewards day as well. So we'll take a look at the market. Fodder is down. Some of these fantasy foot cards are up a little bit, but of course EA is running the late night lighting around. So we'll take a look at how that will affect these cards and how rewards, marquee matchups and everything today could affect them as well. So if you're excited for the video, hit a thumbs up on it. And of course, subscribe if you're new. Let's take a look at these foot fantasy cards because again, it's that time of the week where we take a look at these cards and like, okay, these guys are going out of packs in one day, tomorrow on Friday, new batch of cards is coming in. Last week, we actually had a rise after the rival's rewards timeframe on the foot birthday cards. If you remember that last week. So first, we got to answer the question, if we're going to invest in any of these cards because we think they're going to go up out of packs, why would we invest in them? Are they going to go up? Right? That's the fundamental question. Are these cards going to rise out of packs? What's going to make them rise? Well, again, like we said, and it's almost the same scenario as last week, the cards that are in packs right now are more hyped and more sought after than like anything else on this game, right? People want to try Nani, Gelsen Martins, Kama Vinga. Of course, we have crazy prices for guys like St. Maxim and Rashford, but guys like Stones and Klosterman, Rusilion, Balde, Lucas Moore, a lot of these cards people want to try out and these are more hyped than the cards that have come via SBCs and objectives for the most part so far. So with that hype being there and with not a lot of other insane SBCs, out for people to do besides Mbappe Player of the Month, which was out last week, by the way, when the foot birthday cards started rising as they went out of packs. So that's not something that we have to really worry about this week, this time around. I just think there's a decent amount of hype for these cards and they're pretty rare. We've seen it all week. I mean, take a look at this Nani card, 500,000 coins at the moment. If you look at his graph, each for the past couple days, Tuesday he was 507k, went up to 530. Yesterday on Wednesday he was like 530k, went down to 500, went back to 530. He's now back down to 500 once again. People are buying these cards and trying them out because they're cool and they're hype, right? So as we take a look at this team, can we ask the question, are they going to rise? I think that they might. Again, of course, there's always the caveat. EA is control. There's always the caveat that we could say and the potential that we have to recognize that EA could crash the market at any time with any SBCs, any content that could drop prices, you know, at a moment's notice, but that's the same risk that we always are working with on this game. So I think that we have to be careful in that sense. Of course, with Team of the Season, a couple weeks around the corner, you're starting to see people start to talk about Team of the Season and getting ready for that, posting predictions on Twitter, stuff like that. That's going to start to create some more hype around that big promo, but I think for now we're still in the clear. The thing that I don't like about these cards is that they're, yes, still very overpriced, like Alan St. Maximon. The upgrades are really what's priced into these cards and making them so expensive, but like these cards are incredibly rare. St. Maximon's 4.4, 4.5 million coins still on the market, and I don't know if there's ever been more than like two or three pages of the same Maximon card on the market at all time, or at any time during this promo. So these cards are just, they're just rare, right? The lightning rounds, I don't think EA sell on a ton of packs, even though they're putting out tons of lightning rounds, it looks like a lot of these are not going sold out every time they open up and every time they put them out, and that's making these cards pretty, pretty rare on the market. So those are things that make me like these fantasy foot cards for potential investments. Now, let's talk about which one of these you maybe want to look at investing. Well, we have, again, like I said, a good comparison last week to Foot Birthday Team Number 2. If we take a look at some of these cards, we can kind of notice, all right, which cards are more likely to rise out of packs with hype, right? Now, of course, all the cards from Foot Birthday had the five-star skills of the five-star weak foot. That was hype about those cards. This week, we have foot fantasy items with potential upgrades that are starting later on, but the potential to get a plus one, plus two, plus three, and relatively quickly based on, you know, how that player and how the team plays, getting a win and a goal and an assist for an attacker like Gelson Martins or Nani or Inaki Williams or St. Maximon, that could come as easily as the first weekend after these guys play. So the upgrades might be here sooner rather than later. It could also, the flip side of the coin is, it might take them four or five games to get all their upgrades. Then you're like, okay, then we're on the doorstep of team this season. But again, what rose the best from last week from Foot Birthday Team Number 2 were the more expensive, the rare cards, right? Firmino and Dibala had some of the biggest percentage point rises besides Domitin Sanchez as just a very, very cheap, primarily center back with really good stats and a popular card in FIFA. A lot of these higher tier, more expensive but not super crazily expensive but just more rare cards. Dibala was 1.05 mil on Thursday and Friday and look where he rose to right now today. 1.27, the man is flying in price. On Xbox, he was down to 990 and is up now at 1.1 million coins. So some nice rises on a lot of these Foot birthdays. Firmino is another one. He was like 1.04, 1.05 mil. He's up to 1.27. Danny Alves was down at like 575, I think on the PlayStation as his lowest price. It doesn't show in here. He was down in the 570s and he's back up to like 620. So he had a decent rise. And then of course the Domitin Sanchez which is just a very meta center back in the Premier League. Huge rise on both consoles for cheaper budget Premier League squads. He had really good reviews, five star skills and you know, Domitin Sanchez, everybody remembers his cards from older FIFA's. So they want to try them out with the cheap promo item in this game and people that run Prem teams switch and swap out players like all the time. So looking at this team this week, who do I like? Well honestly, there's a lot of cards in here that are too like, right? Roussillon, French left back. The other French left back that we have is Delayne. He's like 170,000 coins. I think Balday is a serious striker. Give that dude plus one or plus two. He's going to look really cracked. You know, Stones and Kloserman, Kamavinga, Gelsen, Martin's, Nani, Vanda Beak, I think could be a player that is similar to the Domitin Sanchez of last week. I mean, 120,000 coins for a Hullip Gang center mid into Prem. I know he's three star, three star. Only Donnie Vanda Beak's special card that we have had this year. It's a nice boost. It's a nice item. I know Everton aren't playing that great, but Vanda Beak often plays for Everton and if they can get a win and if he could somehow get an assist, which you know, anything is possible after these teams come back from international break. Some things might turn around for some of these squads, right? Maybe that break is what they needed and that's part of the fun with these foot fantasy cards and that they're alive items as well that adds to the hype. So I just think there's a, there's a lot of items in here. Even this Jimenez, I mean, I know the stats are not as good as like Kunde and Nadeedis Militao, but the potential for an upgrade, he's high rated, 90 rated.  He's going to become a 92 or a 93 rated card, most likely. And in terms of fodder, 93 rated cards, 92 rated cards, I mean, Lewandowski's 80,000 coins for a 92. You know, same thing with the Ericsson as well, right? These guys are some of the cheaper 90 rated, Ericsson's 53K. If he gets a plus three, the cheapest 93, well, it's messy and then the Lewandowski specials, but you know, especially if these guys get upgrades and have the potential to more, they're probably going to rise upwards of like 90,000 coins for Jimenez and for an Ericsson as well. That's just my opinion. You know, I think some of the lower tier cards could do very well since they're on the fodder side of things or closer to that fodder range like Jose Sa, right? He keeps a clean sheet and you know, they win a game. He plays in some games. He plays and starts just about every single game for Wolves. You know, that card is as a fodder item, probably going to go up to an 88 and all of a sudden, he's going to be around like 30,000 coins, maybe even a little bit more than that. With upgrades, he'll maybe become a little more usable as well. So take your pick honestly on the cards that are on this team. I think a lot of them do look pretty good. Again, the only thing of worry that I have to say is we just have to be careful because yes, of course, right now we are in a time where the market is inflated on these cards specifically because people are very hyped about them. They're brand new. They want to try them out and you know, team of the season is around the corner. So these wouldn't be cards that you would want to buy and hold on to for that long of a time. I think this would be like a shorter hold kind of situation. Maybe it's through the next week. Maybe two weeks max. Or maybe right until they start getting the upgrades if the team in the season like market crash, panic selling type hype hasn't come by then. I think that's kind of what you're worried about. But you know, as we get into that first week of April when these games start and when these guys are getting potential upgrades, I think these cards could hit a peak then if not even before then depending on the card and depending on what else has dropped SBC wise and content wise. So that's kind of what I'm thinking about these cards. Now let's talk buy windows, right? Right now it's late night 2am UK time per usual when we're recording the videos and they're running the lightning rounds. And it's a Wednesday night heading into Thursday for me and they're running the 85 plus star lightning round packs. These probably aren't going to sell out over the hour that they're there. Well, there's a little bit of supply coming in as people are opening these. They're going to run the next two hours of lightning rounds as well. Probably going to have more lightning rounds today on Thursday as well and we're going to have marquee matchups supply. So when we kind of look at buy windows for these cards, you know, marquee matchups, lightning rounds today on Thursday is going to be a great opportunity, I think, to pick up on a few of these items, whichever one you want. If it's a buy for your team, especially if it's a card that you're just going to buy during the promo like, all right, ball day is 49,000 coins. I just want to buy him because he plays for my favorite team or for the Syria squad. I think he's a great budget striker, that sort of thing. I think today on Thursday might be a great opportunity to go ahead and do that. You know, it depends on what content that EA drops today to, of course, but if EA dropped some pretty good content, that would make these cards drop down a little bit lower, like another player, big SBC of some sorts or something like that. That would be something to keep a watch on. 120 for Vanderbeek. That's sitting as well. Wow, that's crazy. That's kind of the lowest that he's been all week. So, you know, I think that today on Thursday could be a time to watch these cards. Also, tomorrow on Friday, like we did last week, if the content on Friday is not good, what you're going to see is these cards that are not being replaced with a hype item from team two of Fantasy Foot are probably going to jump up and price like right away. We saw this exact same thing happen with DiBala, with Firmino, with Dani Alves, with Lucas Paqueta last week on Friday for the Foot Birthday Team. Two cards, if the content on this Friday tomorrow is not good, these cards are going to rebound, right? Some of them, not all of them, but some of them are going to rebound right away, maybe even like a Gelson Martins or, like I said, maybe a Klosterman. Lucas Mora, being from the mini-release, is going to make him a little bit more rare. I do agree. This card is still overpriced. Mora right now is $870 on the market. Again, I think this card is overpriced because you have a Sancho that is better than this item. But again, it's the potential upgrades with this card that could make it look insane. You know, it's got everybody excited. So, those are some of my thoughts on those Fantasy Foot cards. Some of them might even go up a little bit today with rivals rewards, right? That actually happened last week with the Foot Birthday cards, which was I was not expecting, but it happened, right? Some of these guys actually went up and it could happen again today. So there might be a window to trade with these guys in the short term, but I would be careful holding on to them for too long because I think what you're going to see is, of course, once we see people get their, you know, the rivals rewards today, maybe there'll be some team buying and some squad building as they go out and get those players. But of course, with the Thursday content, that's going to bring some more supply on the market. So I'd be careful flipping these cards after rewards today if you're going to be going and doing that.  We're still going to keep an eye on them because they could rise in price because they're live, they have hype, and that upgrade potential is what everybody wants to buy these cards for. So that was a lot of talking on one subject, but I just want to cover that because that's a big point right now on the market and a lot of people are thinking about these fantasy foot cards. Now, let's get into some of the other content that we have to speak about. Of course, we're going to wind it back to yesterday on Wednesday. The content yesterday was not very hype, right? We had a daily SBC for a pack, we had Silver Stars, we had Lightning Rounds, and we had headliner upgrades that haven't even happened yet. We have an 86 rated CLOS card that is supposed to be 87 rated. At the time of me recording this, he is not upgraded. EA forgot to press the button for the upgrades on CLOS and Zakaria. Both of these cards should be getting a plus one because they won their win streaks. So, of course, CLOS should be becoming an 87 headliner strength. Or sorry, not the win streak. He got the inform. It's a win streak for Zakaria. He's going to an 88 because of that. CLOS is going to an 87 because he got an inform in this week's team of the week, which, by the way, this week's team of the week is not bad. Opening team of the week packs value-wise. You've got multiple cards, over 100,000 coins. You've got Comana, ADK, Bomb Yang 63, Ben Yetter 121, and Sun is 273. It's not a terrible week to be opening that pack just for a value perspective. I know there's no Ronaldo in there that's like 500k, but you have a couple of those mid-tier cards as well that are going to be more common to pack, at least for right now before we get to Friday and there's more supply. It's not a bad time to open team of the week packs, just being completely honest. So, the market yesterday was pretty quiet, right? I'm still holding on to a lot of the stuff that I bought on Tuesday, the out-of-pack special cards. You know, I have some Mateus Cunhas, I have some Kyle Walkers. I still have a lot of these cards on my transfer list that I purchased and picked up. I have some Spinazolas. I bought a couple 88s. I bought some Rommels and a lot of Rommels and some Kane. My first kind of fodder movement, I guess. I'm not unassigned. Nothing crazy like that. But because of the lightning rounds, you know, a lot of this fodder dropped down yesterday and I know that the icon player pick SBC went away so that could be some of the demand has gone away as well for some of these cards. But I think that people are going to get their rivals rewards today and it's going to be a much needed injection of fodder. I bought Kane's it. What was that? Hey, wow. Kane is back up to 53. That's kind of crazy. Rommels, I got at 27. He's up a couple thousand coins. But I just think that people are going to get their rivals rewards today, go out and do SBCs or buy some of the promo cards from the current team. So that's why I think you're going to see that fodder go up a little bit after the rewards timeframe today on the market. Now, speaking of packs and rewards and stuff like that, we have a couple leaks and pack code items here to cover. There are three new packs that were added to the code just last night. Now, they're not anything crazy. I think these to me are more leaning towards SBC packs and not necessarily store packs except for maybe a couple of them. We have three packs. Here's the first one and it's called an 84 plus star duo players pack. This one to me is going to be a store lining round pack because it's similar to like the 85, 86 and 87 plus star. It contains six gold rare players with two guaranteed to be 84 rated 84 and higher. That's that pack. I think it's going to be in the store. Then there's another one called the three 83 to 88 rated players pack. I honestly think that that's going to be I don't think they're going to put that in the store. That'd be maybe they'll put that in the store. But I mean, I think that one could be more likely an SBC and then also there's one that is a 75 plus times five 575 plus rated rare players that screams SBC to me. I don't think he would put that in the store to ask people to spend money on it. I mean, to me, that is an SBC pack. So again, the 83 to 88 it's just more of like a fodder pack 75 plus times five. Interesting. Whatever. And then 84 plus star duo that to me since it has 84, 84 plus star and since we have other packs with that star in the name. I think that's going to be in the store at some point for some sort of FIFA point sale or something like that. But those are the new packs that we have added again. Nothing crazy, but at least interesting to talk about. And then also I want to speak about this. These are our first icon moments player SBCs that are elite to be coming. There's no date for them yet. But hopefully it's within the next couple of days. It might even start this Sunday. That could be maybe even as soon as today. But I feel like this Sunday could be a very opportune time for these as well. Ashley Cole moments and Socrates moments. He says again, both icons were scheduled or sorry, they're not scheduled yet. So that means we don't have like a specific date for these SBCs could be dropping. Both Socrates and Cole dropped off a little bit in price yesterday, but not too much. So I think that they would drop off a little bit more when a leak comes out saying, hey, these guys are going to be getting an SBC and it's going to be today. So hopefully EA can price those very nice because this Socrates card does look pretty dope. And I know a lot of people would want to do an Ashley Cole moments SBC as well. Because hopefully it's like 400,000 coins, 450K or less. That'd be pretty craftable for an icon moments, English left back. That would help out with a lot of people's squads. And then this Socrates would just be a cool one to like collect and put in the club. 99 shop powered, 99 long shots, 5 star weak foot. He did get a really big balance upgrade from his other cards, like plus 22 from the mid and plus 20 from the prime. So this is going to be the most usable version of Socrates you're going to get. Still going to be a little bit of a chuck, but it looks kind of like a cool card. So that's a nice first leak, I guess you could say. Other than that, we don't really have a lot. A couple of marquee matchups leaks today, Brazil, USA, Portugal and I don't even know what flag that is, but I'm guessing those are Senegal. I think that's the, I think that's Senegal or Cameroon. I never can get him straight, but those are going to be evidently the something to do with the marquee matchups getting released today. The new codes that are there. He also mentioned cross platform will be tested in FIFA 22. Not sure how they will do that. Maybe sometime during the summer, they'll throw something out or maybe it'll be sooner than that. So not a ton of leaks right now, which is fine. But I just wanted to update you guys on the things that were out there and that were being talked about at the moment in terms of the leaks. So speaking of today, Thursday content, just to kind of end the video off and talk through the last few things. Of course, we have rewards today. I mean, as I mentioned, I could see the market going up a little bit. That's why I held some of my out of packs cards. I did get a Lucas on bid for 8.54. I thought that was pretty low. We'll see what the late night lightning rounds, what he goes to, but you know, we could see some of this market going up a little bit. And that's why I didn't I didn't rush to sell any of these cards that were on my transfer list. I got these Mateus Cunhas at like 89 to 90,000 coins for most of them. I really hope that today he can just kind of inch over that 100,000 coin mark. I know there's a lot of people that have still held on to these cards that invested on them on Tuesday when the market dropped a lot as well. So if there's going to be crazy leaked content for today, he's still like 93, 94K. So there's that. But if there's any crazy leaked content for today, you're probably going to see a bit of a drop in the market with pain of selling from other traders that are seeing the leaks and that are selling cards that they have because of the leaks that they see. So just be careful with that, I would say. If you do have some cards on the market and you're expecting a rise today, although it does seem to be primed for at least a little bit of a rise as people may be gone and buy some cards back. This team of the week, like I said, has some decent players in it. People will be playing for Reds and Pax with Fantasy Foot Team 2 going to be out, of course, this weekend. A lot of people want to get Pax for the new team being out there as well. So again, today, content Thursday wise, I do think I'm going to see, expect to see lightning rounds again. They've done it the past two weeks, the same exact way. They've done the 85 plus star Pax like multiple times. They did lightning rounds yesterday at 6, 7, 8 p.m. UK. I think they'll do that again today. 6, 7, 8 p.m. UK time. And then we'll have marquee matchup supply as well. The thing that we don't know about is are they going to release an icon upgrade pack? We don't have any icon upgrade packs right now on the market. Which is very interesting, which we've had either a prime icon upgrade or a mid or prime player pick for like the past two or three weeks. And now without having one of those there, it seems a bit bare. So I'm curious to see if EA do anything about that today and if they release something, there would most likely be leaks ahead of time. We also could see another player, SPC. We've had Antonio Tonali, Kali Aguri, only three of them. Maybe we get a fourth today as the last full day of the team one promo. That would be something to watch out for as well. So, again, like I mentioned, SPC fodder without the icon player pick being there, I think that will pull some fodder cards up a little bit because a lot of fodder has gone down. Because we still have the Mbappe, we still have a lot of other SPCs that are available that people would want to go out and do. But I do think that not having the icon player pick there might hurt a little bit of that demand. Just a little bit. So, I think we'll still see a bit of a fodder rise in some areas.  But we'll see, right? We'll have to see what EA Sports has planned for today on Thursday. I'm really going to be watching the fantasy foot cards on the market to see if any of them drop in price or are investable or especially with the late night lightning rounds tonight. Maybe if we see a slight rise before rewards, this could be something that we get involved in. Involved with and take part with if we see prices that we'd like enough on the market today. So, it's going to be a very interesting couple of days, couple of hours on the market with a new promo coming out. Is EA going to do anything crazy? Or are they just going to kind of let these cards stay high, release average content and keep us thinking about team of the season looming out there but not actually being here quite yet. So, that's kind of all my thoughts right now on the fantasy foot cards investing in them. I do think I'm going to be putting some coins into them. I really do. Depending on the time frame and what content is that is what would change when I would go out and buy those cards. So, that's going to be the video today boys. If you did enjoy, smash the thumbs up on a comment down below if you have any questions and subscribe if you're new. It has been Nate, The Foot Account and I'll catch you guys later. Peace.


So thank you for staying with us. We now have the last part of the lectures on our tools and how to access the data in practice.  And I'm going to start with showing you just how you can get our data because we have a lot of data integrated and maybe you need it for your own analysis. And the first thing to be clear about is that our BG data is completely free to use. It is released on the CC0, creative common zero. That is the license which means you could, which is the same as a public domain. So it's like the text of Shakespeare or something. You can completely do. So this is the same as, for example, all the resources at the NCBI. So if you take a gene sequence, a gene bank, you don't need to ask them for permission to do sign with it. You don't need to cite them. You don't need to do anything. There's no legal obligation. It is totally with no legal obligations. Then there are academic standards, which we expect that if you use BG a lot, you would cite us, but we are not going to send lawyers after you basically. So that's the first thing. And I have a small work lab poll to make sure that this is clear for everyone. So I will stop sharing to launch the poll. So there I have launched the poll. Can you please vote on the availability of BG data? Yes, so it's a different link from the master document. You have the link to the work lab of this. Right, so the work lab link is always the same actually. So if you just keep that tab open, it's always the same. That's what's nice with book club. And since I just explained it, I hope it is clear, but this way we reinforce the learning. That area you can tell the SIB training group that we learned from the trainers course. So I think this is pretty clear. I'm going to restart sharing immediately. Okay, so do you see the work lab on your screens? Am I sharing the work lab? Yeah, yeah. Okay, so everyone agrees the data is freely available. So I think this is clear to everyone. That's cool. Now, when you download our data, we have download files that you can access from BG and we can provide either process data or expression codes. What we call process data is really the quantitative data. So for RNA-seq will be counts, RPKMs, TPMs. And we provide process data for the data which we process and where this quantitative expression is relevant. So AFI metrics, bulk RNA-seq and single cell RNA-seq. We do not provide it for in situ because it comes from the model organ database and we do not provide it for expression sequence types, ESTs because we have it for historical reasons, but it's not such good data. And you get for each species a folder you can download which is compressed and you can uncompress which will contain all the information of processed express data. And so you can know that this data has been already curated. So it's wild type, healthy. You can know that if we tell you this is liver, we check that it's liver. And you can know that it was processed by uniform pipelines so that if you compare the different data sets and combine them and some analyzes, they will all process the same way mapped to the same genomes in a consistent manner. And we also have files with expression calls. So what Freddy was just explaining, where and when a gene is present or absent and you can download this. For example, if you want to filter, you want to do some experiment where you want to limit. So you want to look at interactions between proteins in the brain, but you want to limit to genes which have expression in the brain and not have all the interactions which are found by an interaction experiment but for genes which will not be in a healthy individual expressed in the brain, you can download this and filter present in the brain. And you can either use alcohol or decide to be more or less stringent since we also provide the P values and FDR corrected P values.  So that's what the simple files are. You're just going to see the anatomy without much details summarized over all the data types or advanced where you're going to be able to see all the parts of the condition if you want to set on sex, development of the stage and so on and also the different types of data. If you only trust calls from RNA-seq, but not from microarrays, you can filter on this. And these are classic CSV files that you can import into any tool such as our Python pandas, except if you have enough memory depending on the file. And so what's in these files? In the process file, you have the experiment ID, the library ID. So all the information if you need to go back, library type and then for each gene, so you have a row per gene per library, you will have the gene where it is expressed.  Then you have all the information. So if you just want the raw read counts and you want to treat them, you can have them. We also normalize by the alternative normalization TPM which we recommend and FPM, which we provide for historical and consistency reasons. You have the rank which corresponds to the rank score that Fredy was speaking about, whether it's present with what p-value and how it is used in BG, if you want to be consistent between what you see in the libraries and what you see on our webpage. It could be found present in one library, but because when we combine it with the other information with the correction for multiple testing, the FTR, it is no longer considered present, so it could be not part of the code. And we provide something similar for my query. And then for the present absence, you have a simplified with the gene, it's name where it is expressed, when it's expressed. So you have here the anatomy, development and so on. This is the simplified, so there's not a lot of details whether it's present, what trust we have. Fredy spoke about gold, silver, bronze, and it's an expression rank again, and you have complex or simplifies. So this is our data, now how do you obtain it?  So here I clicked on human to unfold this box where you have all the downloads. So you can download the process data here with the RNA-seq, Afimetric or Singer-Stell, just the experiment information to know what experiments we have, which is smaller or all the full files of process data with the counts, TPMs and so on. And you can also on the webpage access, if you can switch between accessing these process data or the present absence calls data. You can also get it directly to an R package, and if you're working in R, I really recommend this way, because these files are quite big and annoying to pass yourself, whereas in the package, we already have all the information to all the methods, sorry, to pass our data. So it's our functions, which allow you to directly retrieve RNA-seq or microarray data from BG, and we provide you process gene expression data with functions to format into an expression set object, which is classic bioconductor. Our package is treating expression, and we have a publication, and we have documentation on bioconductor, and because part of bioconductor, we get regular alerts, which makes sure that we always make sure it's working on all the different environments. So if you have some older version of R on Windows, it should work and whatnot. So that's one way to recover, and so now I will do another work-lap, exit, and here I'm going to poll you. So this is not a quiz. I want to know from you, if you see these different ways of getting data from BG, what would you like to do? How would you like to get data? And I presented you the webinar, but we also have FTP and Sparkle for those who are more into programmatic access. So if you can tell me what would be your favorite way to get the data? So we don't have a hardcore geeky by information accessing through Sparkle so far? Because I have hidden slides to present the Sparkle endpoint. I totally do it if people vote for this. So you can tell your hardcore by information friends that we do have a Sparkle endpoint. Okay, so most people want to download from web or go through the R package. Okay. So thank you. This was just a little poll to know how you feel about it. Now I'm going to present the gene page. I will be pretty short on this because both in my demo at the very beginning and in what's really presented now, we heard a lot of the gene page. So just to make sure that we, when I present all our tools, we remind you of this. Expression conditions are defined in the gene page by anatomy, development, sex, or strain. You can restrict the data you use. If you remember earlier this morning, I showed you that we had the list. We could click yes or no for RNA-seq, microarrays, and so on. We show significant present and significant absent from direct observation and for propagation as pretty just explained. You can see the orthologs and the paralogs which we take from the OMA database, the ortholog metrics database, the database of orthologs and paralogs. And you can send them directly to our expression comparison tool or just get the list. And we have cross-references at the bottom of the page too. For example, Uniprot ensemble, which is our key reference for genes, which are for species which are an ensemble. And for model organ data is when it's relevant. For example, if you go on a zebrafish gene, there will be a link towards Zeefin, which is the model organ database of zebrafish. And I have a little work of this too. So this again, asking your opinion, I would like to know when you go to the gene page, what would you like to see first? So you would like to see, you can click on only one or several. So if you only interest in development decision, not in anatomy, sex and strength, just click on this. But if you want to always see all four conditions together, click on all four, okay? Yeah, actually we won't be able to distinguish between people who want only sex or all of them at the same time. This is not a full usability study. Yeah. But at the same time, it confirms that there is, the first access of expression that most of you want to see is anatomy. Okay, so thank you for your votes. So I see that there's the less love for strain and development of stage and sex are obviously important, but really anatomy remains the main structure. When I ask where is a gene expressed, when I ask about the expression pattern of a gene inanimate, I usually mean it's expressed in the brain. Or where that's consistent with our expectation. Thank you. Now I'm going to present a bit more complicated tool. So these are went fast because this was stuff you already heard about just putting it back in context of the tools of BG. This is a tool we haven't spoken about yet and it's quite important. So I'm going to take a bit more time on this. Top Anat, top leg, the top and Anat leg anatomy. So what top Anat does is does very similar to a gene ontology enrichment, but instead of asking what gene ontology functionalizations are more frequent than I expect by chance in my list of genes, I'm going to ask in which analytical structures are my genes more expressed than I expect by chance? So I have a list of genes and I'm going to ask, are these genes actually much more frequently expressed? I have, for example, digestive genes are they much more expressed in liver and intestine than expected by chance. And for example, if I did some experiment where I was trying to find the list of genes but I don't know if I did, this would give me a strong confirmation. So for each gene in BG, we have expression and anatomical structure. That's what we do. And if I have a list of genes, some structure will be represented many times in the list. It means that many of the genes on my list have an association to the same anatomical structure. So for example, here I have a list of genes and in my list of more than 3000 genes, I have 300 and 500 more genes. I have 46, which have expression in the frontal pole of the brain, which is Euberon 2795. So I have here 46 of my genes in my list which are expressed in this frontal pole. I also have, sorry, my list is only 100, sorry for my mistake. I also have 56, which are not expressed in the frontal pole. So is this 46 out of 112, 102, sorry, more than expected by chance. Well, I can compare what do I expect from the general genome. And if I look at all the genes in the human genome, this is human genes, I have about 10% which I expressed in the frontal pole. This total is much more than the 20,000 protein coding genes because it also includes non-coding genes which have significant expression, okay? And so we can do a ratio between these two. And we find that I have six times more expression of my gene list in the frontal pole than expected by chance if it was these proportions. And so we can do a Fisher exact test which like the more exact version of a chi-square test. And we find that, sorry, this is expected, the six, I would expect six. So we have 7.6 times more than I expect. This is super duper mega significant. And even if I correct for multiple testing, I tested over all the anatomia structures, it's still very significant. So we have a strong enrichment of the genes in this gene list in the frontal pole of the brain. And these are genes which are the number one example. If you go to the top of that website, we have pre-computed examples. These are genes which have been from various studies associated with autism and similar phenotypes. Autism and schizophrenia, actually, that's it. Okay, so it makes sense biologically to find them more in the frontal pole of the brain which is known to be involved in autism and schizophrenia. So in a more general way, what we do is that for each anatomia structure for which we have data, we're going to compare our gene list to a background, look how many I expressed there relative to expectation from the background, do a Fisher or hypergeometric test, and we're going to do a deconvolution of the ontology graph, which is a bit complicated, but basically if you have a gene which is expressed in the frontal pole, it's necessarily also expressed in the brain as Fidelic just showed. So if these genes are more expressed in the frontal pole, they're also more expressed in the brain, but that's not extra information, it's the same information which I'm saying again. They're the same thing in the gene ontology. If you have more hydro lasers in your list, you probably have more enzymes because hydro lasers are a type of enzyme, but that's boring. So we have modified the R package top go, which is a package for gene ontology enrichment, which does this deconvolution and we've modified it so that it treats not the gene ontology, but uberon, the ontology of anatomy, and we can do the same deconvolutions. So if you use our top anatomy tool, so it allows you again, you can put any gene list and get the enrichment in anatomy structures across any species which is in BG. Obviously the species for more data will be more powerful, but you can do it in any species which in BG. And something I should mention here, I didn't write on the slide, it only works on data which is observed in that space. So if you do a gene ontology enrichment test on platypus, what you're going to see is what we hope to be the function in platypus from blast hits on human and mouse, basically. No one has done the molecular studies of the gene function in platypus. If you do a top analysis on platypus, what you see is expression in platypus, strictly in platypus. So it's experimentally observed in platypus on data which was curated from platypus. None of you study platypus, but it's the same for any other species. So if you do such enrichment analysis in this tool, both for gene ontology and for anatomy, I just want to attract your attention to these important pitfalls. Background is critical. Here I compared my genes to the whole genome in the example, because any gene in the genome could have been found associated with autosmoschizophrenia. But for many studies, you could not find all genes. If I look at genes for which I find positive selection in humans right up to chimpanzee, that's only genes for which I had autologs between human and chimpanzee, and for which I was able to do an alignment and calculate positive selection. And so my background should be those genes, not all the genome. And this is very important, because otherwise you get very wrong with that. Because we test over all the anatomical structures or the gene ontology, all the go terms, we have a lot of multiple testing and you have to pay attention to this in the interpretation of your results to the multiple testing correction. And as I mentioned, the terms are in a graph, as you've seen, so they are not independent if you're in the frontal pole, you're in the brain. So it is very important to pay attention to this. I mean, you always have to de-correlate because sometimes the interpretation without de-correlation makes sense, that you have to be aware of it, pay attention to it. It's the biologist who must make the final interpretation knowing the pitfalls. Or we can use, in top and at, the algorithms from top go for de-correlation, ALM, which is very stringent, or weight, which is less stringent. And top and at is on our webpage and is in the BGDBR package. So you have a gene list, you want to look in a cool, easy way. You can just paste that gene list on our webpage like you have many web pages for gene ontology enrichment. But if you also want to include anatomical enrichment testing in an R script or pipeline, if you have already in R, you already have your gene list there, then you can just call our package and very easily get your anatomical enrichment and also all the options which exist in top go package for those who know it are in the top and at version in BGDBR, whereas on the webpage we had to restrict a bit the options for usability. So here I'm going to ask you on the Google Doc. So I'm going to the Google Doc. Oh, there. Can you tell us a gene list that from your experience, you would like to test in top and at when you have time, you'll go back to top and at think, oh, this is cool. I can test where my genes are expressed. And I have this list of genes from my work. What would be the list of genes? Genes involved in caskizofrenia. So I see some gene name. I think if you write all the gene name, that's going to be a bit long. So more general list like, you know, genes involved in this disease or this process or found by this test for selection or different reacting to this drug and so on. I don't know if you hear background noise on my side, but we have a campus day of visit of kids. So I have a lot of noise behind. So I'm sorry if you hear kids screaming. Home and ambassador disease genes, nice inflammation genes, genes for tissue resident memory T cells. What do you expect to find them expressed? Let me ask. Jose. Okay, so thank you for your examples. If you have other examples, you can add them. So I think it's most from my experience of playing with top and up for several years. It's most interesting when you have a pathway which is not directly anatomical. For example, home and ambassador disease genes. And you're wondering where are they expressed? Jesus first in liver endothelial cells will probably be expressed in liver endothelial cells. So it can allow you to check that our database works well, but you might not learn so much new biology, right? Inflammation genes is also interesting. So I'll go back to my slides. Thank you very much. You can continue writing if you want. So one thing that BG does and is quite unique, I think, is that we have homology of anatomy. I don't think it's unique. I know it's unique because the other people who said they would do this 10 years ago, didn't because it's way too much work and we were the only ones crazy enough to do this. So what we do is that our bar curators, mostly only our lead bar curator reads the literature on homology of anatomy. So you know all autology of genes, but there's also homology at the anatomical level, right? So our arm is homologous to the forelimb of a mouse and to the wing of a chicken, right? So that's anatomical homology. And a lot of anatomical homology is not trivial. So our curator reads pathontology literature, evolution of development literature, comparative anatomies, zoology literature, textbooks to get the most accurate information on this homology. And this is all recorded in our database. And so we give you access to it. And the first way we give you access to it is we have a tool which you will find in the, if you unfold the search menu here, there is a search for anatomical homology. And there what you will find, you will get to this page where you will see the, you will be able here to put identifiers of uberone or synontology, you select species, and you can find which of these anatomical structures are homologous between these species and what is the homologous structure? So here I put all the anatomical structures from human, which have been studied in the GTEC project. And I asked, do they have homologous homologs in the zebrafish Daniel Rario, which is the model organism, the most amenable to experiment in fish? And so the question is, how many of these structures which are studied in GTEC, can I compare to studies in zebrafish? And I have 31 here, which have, where's my mouse? I lost my mouse, that's cool. I don't know where my mouse is. So I have 31 which are in the, now I got my mouse back. Okay, 31 here, which have homology. And you see that sometimes the homology is quite simple, both zebrafish and mouse have a hypothalamus and it's homologous. Sometimes it's not so obvious. So the left ventricle of the heart and the primary heart field are homologous or the lung, you see the last one here. And again, I lost my mouse, this is a knowing bug, okay, here. Here the last one, you notice that the lung of the mouse of human, sorry, is not homologous to the gills with which the fish breath, but to the swim bladder with which the fish puts air inside and use it to change their level in the water. And this is a well-known fact in comparative anatomy, but maybe most molecular budgets don't know it. So here we give this information. And again, my mouse disappears. This is the bug already had in Zoom. Okay, so that's one thing we can do with the anatomical homology. And the other thing we can do, we already showed you a bit is the expression comparison. So if you click here on the analysis, you can unfold here expression comparison or on the homepage, it's big button expression comparison. Here you can put the list of gene identifiers either from your own study or directly from the orthologs or paralogs of a gene page. And you're going to get in which structures these genes are expressed. And you will see only the structures which have homology. So if the gene, if these are only, these are all brain, this is a brain gene, the first example here.  And here you have, for example, this is Phyllis catus, the cat, and this is a fly base or fly and so on. And you find that overall, everywhere is found in the central nervous system with very high score and found in all species present, right? So this is a brain specific gene common to bacteria and indeed, and what we see here is that I have the central nervous system, which is a homologous description of all the central nervous systems of the different animals. And going back to the Google doc. So this was a rapid presentation of our tools. And I'm just going to ask you again, for your opinion, what is your favorite BG tool? So with everything we presented this morning, what would be your favorite tool to use? Top Anat, the gene page, the expression comparison, the homology of anatomy, the downloading files. Also you can mention the R package, BGDB R package, which allows you to get the data into R or to analyze Top Anat in R. So I'm letting you write your favorite BG tool in this Google doc. Again, if you're shy, you don't have to put your name. The tool is more important. So Vinayaka, you're in the table above or in the table below. Otherwise we can copy paste it. Is the Google doc shared? Are you seeing it? Préderique, can you confirm? Yeah, yeah, yeah. Okay. I don't know. Usually there's this kind of green thing around it. I didn't see it. So a lot of love for Top Anat, either because it's super cool, which it is, or because the last thing I spoke about. Oh, you spoke about expression comparison. You're right, you're right. But I think the Top Anat is very cool. Also, if I may say something really cool about Top Anat is that every time we test it on some gene list, because I like to play with it. So I see some paper with a gene list or some study on Twitter or something and I try it in Top Anat. And the results always make sense. And this is super reassuring because Top Anat is built on everything else we've presented you this morning. So if we made mistakes in curating the datasets and then annotating them, Top Anat wouldn't work. If we made mistakes in the quality control of the data, it wouldn't work. If we made mistakes in calling genes present absent, it wouldn't work. It only works because everything else is correct. So it's also an excellent quality control for us to check that it works. Could I ask to CRV-NAYAKA what would be your use case for additive kinomology tool if you accept to tell us? Because it's maybe the less sighted tool among our tool and I'm curious to know about what you would plan to do with that because it's directly useful to our expression comparison, but alone it's interesting to know, yeah. Okay. It's a relationship. Yeah. And so I should emphasize again that additive kinomology you see is not, is never derived from our expression data. Because this is a question I get quite often. We do not use our expression data to derive homology. Because then it would be circular if we use our expression data derived homology and say, is it conserved in the homologs? Well, yeah, because that's how we calculated it. Our homology only comes from the literature and in the literature expression might be used as a evidence, but then it's used as social evidence someone external to BG who's an expert who's been considering this and usually it's specific marker genes, for example. And then we, if you are really interested in our antimicrobial homology, we have a detailed file on our Github where you can have all the details of how we inferred it with every line of evidence and every bibliography reference. So maybe the same homology has been reported by three different studies, one based on process, one based on the marker gene and one based on developmental patterns and we will give this separately. So thank you for your contributions.


Welcome folks, this is Tom O'Brien of TFNN. We have five days a week, we go seven hours a day, we go 24 hours a day in the internet, at tfnn.com. Always remember folks, whatever you think about, you bring about whatever. You focus on growth, hope everyone's having a great day, safe day, making a great week and a great night folks. Serve the one you love.  My advice, let's take a look at it out here. We have the Dow Industries right now, up 183. Nasdaq's up 84, S&P's up 28. Gold contract down 1360 at 1857 an ounce. You got silver up 18 cents, $22.28 an ounce, light sweet crude up a buck, $4119.91 a barrel, notes and bonds. The 10-year note, up 14 ticks, trading 1812, the 30 up a full point, plus seven ticks at 137.28 and King Dollar. King Dollar right now trading down 127, 102.310, Euro 107, Yen 132.55 in the British pound at 125 to one US dollar. iPhone number's 877, 9276648. Give us a call folks. One note's going on in your world. In the world of the S&Ps, let's take a look at them. What do you have? Well, bottom line folks, you get a rejection of lower price, you're going to have lighter volume. So let's just go through this whole scenario. You know, we're going sideways for five days. Yesterday was a big day. The reason was yesterday was a big day is this. You can see that, you know, you bottom line, you had got over the highs of Friday. Friday had 71 million shares. Today what you had, yesterday had 57 million and you gave it up on price. When that happens, guess what? You're going to try to go downtown. What do we do this morning? We try to get out in town. What happens? It rejects lower price and you're going to have lighter volume. When that's set up folks, next move is going to be going after the swing high inside of the spy at 41744. And we'll see how that shakes out, man. You know, my take is that, you know, we're going to like 3,500 in the S&P, but the cash S&P, but the bottom line is that right now this thing wants to go charge this 417 once again and we'll see what it shakes out. Now what you want to be really, what you want to be watching is this.  If it takes it out with volume, you get yourself an ABC structure up. That's the bottom line and it would be a big ABC structure up by the way, okay? It'd be a 37A to B, which is a big dump. So keep your eye on that, man. NDX 100, same type of setup. They take a look at the NDX. What do you have with the NDX? NDX out here, 3Qs, bottom line, same type of setup. Yesterday you failed on price and volume. You got up to the price point of 312. You closed out at 305. You had volume of 51 million versus 60 on Friday. What do we do today? Just the opposite. Today the bottom line, we have no sellers. We got down to the price point of 302, 660, 68. That was tested in the 302, 40. You get 36 million shares, where you're going into 59 million. We'll do about 46 million shares. So also the Qs, they're gonna be going after this at 314.50. And you know, we'll see how it shakes out, man. See what, get any juice going to the top side. Gold, gold, same type of setup. What gold did out here today, pretty cool. What you have, come on baby, there she is. Okay, so what gold did is this, get the volume here for us. There we go. So what you had with gold, gold got down to 1838 today. You're coming into 150,000 contracts. You've done 111,000, it's not gonna have it. I rejected lower price at lower volume. Now gold's also gonna make that run for that 1878 mark. And king dollar, this is you don't wanna keep your eye on because it looks like, it's really intriguing. You know, markets always change, that's the bottom line. But what seems to happen now is that if the dollar gives up at all, the market itself seems to get a little juice in it. And this is, this looks to me like an ABC down setup. It failed on price today at 102,730. We hit 102,839 and then basically gave it up. So if it's an ABC down, we're gonna be down like at the 99 area inside of that market. Now let me show you something with target. So this gets really interesting. A target had got a little bit lower folks, okay? The bottom line, it would have been a test of its high volume low. It didn't get there. So I wouldn't get into target, man. But the bottom line, is that what you can see is that target came down hard the first time they came out with their numbers. 145,51 is the number. Well, I hit 147,15 today. It's not good enough. That's the bottom line. If you're taking a look at it, that to me is just not good enough. When you get a test, you wanna test with light of volume and a rejection of lower price. That's what you're looking for. And bottom line, we didn't get that yet. But what target does not have is it does not have a high volume high. And that's a huge deal. Now let's get it over to the OIH. Because this is the OIH is talking, walking and squawking out here today. If it holds price, it's gonna get intriguing because what it's done is that it's come up to its highs once again. The high in the OIH is 312,58. Or 312,78. Volume there was 1.1 million. We'll see whether they can get that right now. You're at 769,000. And we'll see whether it holds price. If it holds price, you get some action. If it doesn't hold price, that's gonna be a test of its high on light of volume in a give up. But guess what? Right now, it's up 876.  They got some real juice behind them.  You got Exxon, up four dollars and 17 cents. You're at 103. See the X. You take a look at Chevron. Chevron's up 347. That's peaking its head out. So that last high was, that's 180,96. We hit 180,53. Yeah, we'll see whether it can basically hold it. You do have a contraction of volume there. But the bottom line is that you get some buyers in there.<PHONE_NUMBER>. We have the Dow. Dow industry is up 166. Nasdaq's up 80. S&P's up 26. They're right there, folks. We'll come right back.


Liz is in the house remember and to celebrate our extraordinary friend Liz Suidos and I welcome all of you here and around the city and apparently around the globe. It's wonderful to be here at La Mama where Liz did so much of her groundbreaking work and it's also really fitting that Ra's in her love and wisdom chose Valentine's Day. First of all Liz had a dog named Valentine but Liz as we all know was so full of love for for Ra's, for her family, for her friends, her musicians, singers, her students, her community and for what she did as only she could. Her work was fierce and passionate and fearless. I especially experienced this the one time I got to work with Liz on the animated film of my depression which must be the most generous honest charming document ever written about this subject. So vulnerable, so funny in presenting herself at her lowest and most tender she invites all of us to take off our armor. My husband Jim Simpson who ran the flee where we were graced by several productions of Liz which I wish were all still running they were so amazing but he's unfortunately couldn't be here today but wanted me to say this if you looked at Liz you'd know she was special. She carried herself with a brave devil may care counterculture kind of vibe. She was always ready for action. Her size was deceptive because this woman was a giant. She had prodigious musical gifts, a sharp visual sense, a sophisticated rhythmic sense, her work always rocked, swung or wailed and she had huge appetite for new artistic challenges. Liz never played it safe. In preparing a score you'd hear an early workshop and fall in love with the melodies. Come back weeks later they've all been replaced by new world. This giant was always on the edge of her big talents and she liked it that way. Liz was also on the side of the young. The establishment could have itself. Liz aligned herself with young people. Their stories, their struggles resonated powerfully for Liz. She was a one-of-a- kind guru. Loving, tough, demanding, professional, ecstatically talented. You wanted her to notice you, to praise you for having half the courage that she had. The surprise was that Liz was already ahead of you. She probably loved you most when you struggled with her challenging score and when you really hit it, she'd figured out long ago that you were capable of it. Otherwise you wouldn't be there. I've never met anyone like Liz. I'll miss her. I'm deeply grateful that we got to share some time together with her. Thank you.  I'm Becky. I know all of you. Thank you for being here and thank you for supporting Roz and each other. Liz was known more for her music than her lyrics. She helped others find songs in their hearts or matched her perfect score to their, to brilliant, she matched her perfect score to brilliant words of others. If you're here, you know what a fantastic friend and listener Liz was. Yet she was very selective with how she would share her own words and Liz had a lot to say. I'm going to share now one of her poems that reflects some of her humor and perspective on the everyday, but I encourage you to seek out her poetry and you will learn more about Liz than you thought you knew. Luddite. I don't carry a cell phone. If it rings from the bottom of my Guatemalan bag, I'd reach in, uptween my wallet, my cards would fall out and I would be in danger of losing my American Express or worse my NYU identification card. They'd keep me out of tish or my keys would get tangled around my fingers. I keep them on a long thick ribbon so I don't lose them. With my fingers entangled around the ribbon on which my keys are tied, I would be in danger of inadvertently yanking out the books I carry. Isabel Eberhardt, Biographies and Essays. Ridiculous. Now I have to squat on the sidewalk.  What if there's a wind? The papers and my purse would fly. I would lose the order of the political review I'm creating with my students if I'm allowed into tish without my ID. How can I direct a show if I don't know the order? The ink could become blurred and the research I've done on the triangle shirt waist factory fire could rip into soggy shreds and of course the Groucho Marx finale to this missing scene is that when I finally find the phone, it stops ringing. Of course if I possessed an iPhone, I could see who called me and immediately return their call. However, I wouldn't be able to see the number without my glasses which as by now you've imagined are buried somewhere in my Guatemalan bag and once I begin to search for them, I am subject to repeat the whole cycle of events I've laid out for you. Truthfully, I don't like talking on the phone. Anyway, I hate the damp mist of breath on the receiver and the voice of on the other end to whom I can't give subtle body signals to change the subject.  My friends want me to get a cell phone in case of emergencies. There's always been emergencies and they've waited until I got home. I could be lost or late. Well, there are some pay phones left or my favorite activity, borrowing the cell phone of a Pakistani cab driver. Life is good. It's raining and dawn and just a gray reason to stay inside. I have an answering machine. I will put it on and screen my calls. All that energy covering an exchange with a friend or a bank. Please, my daughter, don't insist on buying me an iPhone.  Life isn't fair. And we miss Liz. She's left so much, but there was so much left to be said. I didn't know Liz very well. I actually got pitched my depression by my psychiatrist. I don't know if that's an admission, but since you're all in the dark, you don't know me. I don't know you anyway. My psychiatrist gave me a book called My Depression. At first, I thought that this book was just because we matched the book in me. But I saw Liz's name on it. And I said, you know, I thought maybe she had a part time job at William Morris. I didn't know why Marlene this book. And she said, because I think you could do something with this. Anyway, so I took the book home and I read it. And I shared it with my friend Sarah. I don't know Bernstein. I don't know if she's here somewhere in the dark. And we thought, what a great documentary. How great this would be animated. How important this would be. But we would have to meet Liz Svedos. And so I got back to work and I looked up Liz and Liz was a partner of the great, tough lawyer, Ross Lichter. And I thought, Ross and Liz, Liz and Ross. But I grew to realize that that was the most beautiful love. And that Ross was the most perfect wife. And the dream that we would all have when things go askew, that this wonderful human being would be by our side. So thank you, Ross, for loving Liz so, and for staying so long, and making her always in those last moments feel that she was loved. That was so important. So now lightness. Okay, so now I adopted a dog. In the middle of working on my depression, I adopted a dog. My dog had died. I couldn't stand it. I adopted a dog. He came from Atlanta. He didn't have a name. He didn't have ethnicity. Liz felt he was Jewish. And she gave him this dreidel. And when I pulled it out of his mouth to come here, he didn't want to give it to me. But this dreidel puts him to bed at night. It wakes me up sometimes in the middle of the night. I love you, Liz. Bogey loves you so much.  Too soon, so much. Thank you all. Bye bye. This way does. And originally from Buffalo, New York, what we're trying to get to is is the same kind of state, the same kind of fire, honesty that you hear in music in any country where the music is a absolutely complete part of the whole way of life, of the whole way of ritual. Sorry, short. I'll do my best. Remember how we met? Summer of 1972. La Mama Lobby. Ellen with her magic vibes, or as she called them, beeps, made it happen. This is Liz, the red hair girl, fresh from Bennington College, dying to work with Andre, the hope of Romania. Both eager to revolutionize the stage. So you composed magical chants for Medea in ancient Greek and Latin. Then summer of 1974 in a remote village of Bahia, Brazil, together with Priscilla, returning from a voodoo ceremony, looking for inspiration for the Trojan women. You got the news of your mother's suicide, but personal tragedy did not stop you. On the contrary, it gave you strength to create a major opera about the suffering of women and dedicated Trojan exodus to her. My own mother died during electric rehearsals and our destinies got so mingled. Our chemistry was such that Ellen even mixed our names once. Elizabeth was her mother. Of course, you know, she loved us both. Although you were the golden girl always, I was often the bad boy. While doing many other productions together, the trilogy became the landmark and the long lasting achievement in the mama history being performed all over the world. The last time in 2014, at the Opera House in Romania with you being present. And I will not forget the thrill on your face hearing for the first time your music divinely sung by these enthusiastic professional opera singers who adored you. The memorial we recently held there to honor you was felt deeply another sign that your music reached far and deep in the universal soul, free of borders. You've been a Renaissance artist, spreading your creativity in such vibrant directions. You always reminded me of Edith Piaf, like her. You are the central character of your songs. The eternal runaway that never quite found a home, except at the mama and of course with roles. And like most true artists, you had no more an answer to saving the world than anybody else. Still, in spite of all odds, you kept the candle burning, remorse, suffering, effort, hope. This was your process of search, your transcendence, and always with humor, with laughter, the refreshing antidote to pain. Liz, shall I tell you the truth? Ellen was unique. You were exceptional. Or the other way around. I am sure you two have a happy reunion. Dear friends, wherever they are, they watch over us. Our response is delivered in one word. Gratitude, suggestion. And the mama theater should be now be named. Liz Svedos, 10 of us, mom's side, didn't buffalo. And grew up together, of course, had the privilege of giving her her first nickname. I looked at her and I said, This was when she was a little older, and she was a biter. I said, Hello, it was a bite. She did not like that. Go into her house. I would say, Hi, bite. The bite would attack me. There was only one way to get her off. And that was, of course, to tickle her.  Now, we always celebrated the major holidays together, including among them, Passover. And of course, as soon as she was big enough, it was great to have her take over saying the four questions. But there were three older cousins, myself, her brother, Lincoln, and Brian. And Liz became our secret weapon. We would find the afficulman, bring it to Uncle Rocky, Uncle Rocky would offer us a dime. We would pull out our secret rapid. She was sort. She was cute. She had the most wonderful smile. And we would say, Lizzie, ask him for something bigger. So she would ask for something bigger. And of course, he would offer her a nickel. So he said, Lizzie, a little bigger than that. And she would go up and she eventually got him to a quarter. Really a great negotiator. She was terrific. In our family, if you couldn't drive, you had to ride a bike. And cousin Bruce had this 18 inch wide bike driven by a belt. No brakes. He learned to ride on it. Then cousin Brian learned to ride on it. Then it was my turn to learn to ride on it. No brakes had it painted a nice green and yellow. Liz came over one day, it was sitting in the garage. She knew we all rode bikes. And I said, Sure, Lizzie, you can ride it. I don't think her parents ever forgave me for those bruises. But she did learn to ride that bike. And we all rode bikes to each other's houses. And that's how we saw each other. Often, those days growing up, gonna skip ahead a little bit. There's a lot I could probably say about our childhood. But we did keep in touch with each other. And it was very nice one summer when I came back from college, and she had graduated from eighth grade. And she asked me to host her graduation party. It was terrific. She was a great dancer and a terrific hostess. And I said, Lizzie, you're the best dancer there. She said, Kenny, you can't give me the reward, you got to give it to my guests. So I took her cue from that and did what she asked me to. She was learning to play the guitar. And I wanted to give her my guitar, but my one of my other cousins beat her to it. Much later, when we were both young professionals, I met her in New York City. And she listened to me, given argument before the Second Circuit Court of Appeals. And we discussed the case afterwards. I know RJ's listening to me RJ. I think that was the appeal of the case where I took you in here. Here are my closing arguments. Boy, if you ever want to get criticized, bring teenagers in to listen to you. And then she took me to her TV studio and where a television production of the Trojan Women was being performed and showed me what it was all about and everything. And this poor actress was having such a hard time with the introduction in a break. I just commiserated with her a little bit about the difficulty of the script. Later on, we were leaving the studio and Lizzie started to laugh. And she looked at me and she said, do you know what you did? And I said, no. And she said, you know, the person you commiserated with, I said, yeah, it was really a toughly written script to read. She said, she wrote that. That was the same visit where she finally put an end to my teasing her about her true birthday. But I won't get into that. Hey, I'm sure you all have had older cousins who have done worse to you. On Facebook, one of her colleagues at the Buffalo Seminary posted a poem that was in her yearbook, the students were allowed to select the poetry. And it reads, I've been awarded with many medals. I got a springtime for being a little girl many years ago. I've been chosen for the honor of being the interpreter of the gold of the morning sun. Ask the wind for he has seen me grow since the days he carried me around on his shoulders. Ask the willow tree in my uncle's backyard. For he has seen me in the prime of my life before. And the poem is signed. Jay Daisy. Lizzie, I think you wrote that poem. I know that willow tree. I looked at it almost every day for most of my life in Buffalo. Jay Daisy, I think that's a combination of Jay Gatsby and Daisy Buchanan. And I miss you very much. Hello. Thank you, Chris Preston, Roz, George, and everyone involved with organizing this event for letting me say a couple words. My name is John. And I first met Liz through her work when I was 15 in my high school and we did runaways. And I had just been doing theater for about six months at that point. And I remember falling in love instantaneously. I'm from Washington Heights and growing up we didn't really, I'd never considered that being an actor or performance was an actual thing or a possible profession. And I struggled to figure out if I even had a place in the theater. And after doing runaways, I thought I did because I was playing a character that was very much like me and coming from the place where I was coming from. And so that sort of blew my mind. And I started being involved in theater and was lucky enough to about a year and a half later meet Liz and audition for her for a production that she was doing in Washington Heights called Sosua there to dance together, which was bringing together Dominican kids and Jewish kids to tell this story about Jews escaping Germany and Dominican Republic's Dominican Republic that was going through a dictatorship and all this trauma but that through all this trauma people would come together and find this unity and this love. And in the story we did and also in the production we did. From there, I learned so much about Liz and so much about theater and so much about myself. Just through her ability to see through me and see what I was capable of and see what all the kids were capable of in that production. We were all coming from all these different schools, private schools and public schools and some kids who weren't even going to school anymore. And somehow she instilled in us that we were greater than even what we thought was possible. Even when we didn't know it or couldn't show it at rehearsal, she would pick on us to create something even if we'd never created anything at all. That's really where our relationship started and then ended up going to NYU where I continued to work with her and a lot of people in this room and a lot of people behind me. I can't help but think of love and community when I think of Liz because I mean look at where we are from many, many years ago. She was here on this very stage doing stuff and look at where we are now. Everybody coming from all these different communities to come together and nothing was greater than the NYU community that facilitated all of these experiences. And the theater director who introduced me to theater from the beginning was also Liz's assistant when he was at NYU. And that I was up here singing with the Great Jones Company, which she helped found. And I feel very honored to be a part of that community and this community and the NYU community. And I was asked to read a letter from Mary Schmidt Campbell who was the Dean of NYU when I was there. So I'll read that now. Dear colleagues, I am so sorry for your loss. Liz had a talent for spotting what was golden in her students. The NYU reality show was a perfect example of that. Every year she would audition and watch intently for that something, that distinctive glimmer, a glow that beckoned and spoke to her. She saw her work as burnishing and making visible that golden talent that nestled inside of her gifted actors. She once told me that when she auditioned a large number of talented young people, she was looking for a connection between herself and them, a connection that allowed her to build a creative partnership. On stage, the fruits of that partnership were abundantly evident, not only between Liz and her actors, but among the actors themselves and with the audience. Trust was at the heart of all her collaborations. Her actors trusted her with the truth. They trusted her with their bold experimentation. They trusted the private process of developing the reality show and they trusted the public staging of the end product, which is why we, in the audience, experienced the show as honest, authentic and alive. Liz liked to write me every few weeks to keep me apprised of her astonishingly full slate of creative projects, music, theater, dance, spoken word. I don't know how she managed it all. We'd make a date for breakfast or lunch about once a month. On one of those occasions, breakfast at Noho Star, Liz's kindness was in full display. We were chatting away when I reached up and touched my ear, realizing that to my horror, I had walked out that morning with mismatched earrings. What was for me a fashion disaster, for Liz was probably a style statement. Nonetheless, good sport that she was, she helped me find a substitute pair of earrings that morning from one of the Broadway Street merchants. Having retired from NYU and having moved from New York, I already missed her. Bros, you have my condolences and sympathy. Liz was one of a kind, someone who could lure the best from all of us and the necessary presence in the lives that she touched. Now the world will miss her as well, with sorrow, Mary Schmidt Campbell. Thank you for everything. And I just want to close with, as I think about Liz so much now these days, as we all do, something that my theater director always told us was that when you create sound in the room, physics just allows that the waves keep propelling off the walls. And I constantly think about how many rooms I walk into that Liz was in, and that for somebody who created such loud sounds, it's also in her silence that we find so much strength. And so I urge you to just sit in silence sometimes and see if you can hear her sounds in whichever room you find yourself in. Thank you. You may wonder how a Buffalo Jewish composer, writer got connected to an Irish, Catholic, Bostonian, non educator. We were both changed and could not and got stuck with a date in history. December 2 1980, was the death of four church American church women in El Salvador, more o'clock, Eater Ford, Dorothy Kaisel and Jean Donovan.  Neither one of us could let it go. I began the more o'clock Eater Ford Women's Education Center in Bushwick. And while I was there, someone invited me and Mary Dowd, the co director to go to BAM to see this musical. It was called Missionaries, the story of the four women and Oscar Romero. So for the fifth anniversary of the center, I call Liz and say Liz, would you like to put something on for us? Maybe I could come over and talk to you. So she said sure. And you know how Les Mis became a choral presentation. That's what Liz did with Missionaries. And we put it on then and then we put it on a few more times in the city. And it got excellent reviews. She started calling me one of her producers. A few years later, I went back to Liz and said, Liz, could you write something about the center for the 10th anniversary? So she came over and met with the women at the center and myself and put together a piece called Ten Years of Hope. There are two songs there that are important. One, she wrote a song about the two Marys, me and Mary Dowd, which is fun to have a song written about oneself. The second was she sat down and we talked about this room that was very important at the center. Many things happened there. In the midst of the conversation, I said to her, we had a perfect view of the city on 9-11. So she took that and in the middle of the song she put down, they saw the towers from this room. And that said so much to me about who she was and what we experienced. In 2002, I got a chance to go to El Salvador. And the first place I went was to where they found the bodies of the women. And I was standing there and it's a memorial now. And there were bushes all around. And on these bushes were flowers. And I can't sing. So in my head, I started singing one of the songs from Missionaries. And flowers will grow and flowers will grow. And that, I believe, is our legacy from Liz, to make sure flowers grow and they bloom. And we notice all the beauty in this world in the midst of that, which is not beautiful. So now I'd like to introduce Missionaries. Thank you. I'm Judith Ginsburg, executor. I'm not a writer, a singer, or a dancer, or an actress, although I wish I were. I'd like to share with you some of my recollections of Liz and her life. Liz struggled and triumphed for 64 and 1112 months, dying exactly one month before her 65th birthday. And why she couldn't live to be a little old redheaded lady, I don't know. I was privileged to know her for almost 25 of those years. I met her when she asked me to support her creation of a musical performance piece that became the Hating Pot, an unforgettable work of theater. Its cast was a talented, multi-racial, and multi-religious group of New York City high school students. In song and dance, they explored hatred, prejudice, and acceptance. The Hating Pot toured schools in New York, Chicago, and LA, and became a terrific video that was shown on PBS with support from Steven Spielberg's Righteous Persons Foundation and the Revson Foundation, among others. My very own high school in the Marinette, New York shows it annually on its diversity day. And so, we became friends and met very frequently over the years at the City Bakery and the Union Square Market. We shared our secrets. Liz was a tomb, as they say, and so am I, so I can't tell you very much. We spontaneously gave each other numerous material gifts, necklaces and bracelets, yellow nail polish, and a rattle made of animal nails from Peru. That was me to Liz. A fabulous brown and orange scarf. Liz, to me, and a giant wooden giraffe that Liz surprised me with in my office one day and declared that I needed it. I attended her shows and loved them, of course. I wish the reality show had been around when I was a college freshman. I understood her interest in outsiders and seekers, missionaries, the nomad, Casper Hauser. I was deeply moved by her dysfunctional family portrayed in the Four of Us, her struggles with depression, and her triumph over it in my depression. I was charmed by the myth man and the contest with Roz's wonderful photograph on the cover. Liz and Roz would come to us for Thanksgiving and Christmas and became family. Liz's triumphs include success in the two major aspects of mature human experience, as Freud would have said, livened and arbeiten in love and in work. In the love category, she had a supremely happy marriage to Roz Lichter. I was honored to attend their brief, modest, but deeply moving wedding. And who ever thought when we were growing up that same sex marriage would ever become legal? The very best of the many gifts Liz gave me over the years is that of her wife, Roz. But her love was not limited to Roz, and she had plenty to go around. She loved her students, her many, many friends, and her beautiful dogs, rambunctious Leonardo and her darling Clementine. And before them, Billy Bob, Tootsie, and Valentine. Liz triumphed in work, too, the arbeiten part. She was constantly creating, reading, thinking, rebelling against the conventions of her time. She was not into pretty. She was into meaning and justice and love. If any child of God should be allowed to break the rules and attend her own memorial, it should be lit. She would certainly make the most of it, darting about in red sneakers, reblocking everything, exhorting, cajoling, inspiring, annoying, adding bird calls, knocking each of us out of our comfort zones in diversions of ourselves we didn't know existed. Then she tweaked the lighting, the seating, and most likely the script, rearranging the words I'm delivering right now, which she would then set to music on the spot and order me to sing, which I can't, but Liz would insist I could. So I would somehow and we'd all be amazed. Liz was a change agent. No one she ever encountered was untouched. And let us recall just how many lives that involved from villagers in Africa to farm workers in the San Joaquin Valley to a generation of students in New York to run away kids from everywhere. And her message to all them was mostly this, you are not alone. You are part of a community. The burdens of life can be shared. And if you are open and generous to those around you, together, you were stronger. And together you will find what you can do, and combine it with what others can do and what a beautiful, joyful noise we shall make. Experience teaches us there are no charm lives, but I do think there are lives a few that are magical. There are special few who can reach out and touch the many, creating wonder and delight and mystery and mayhem all at the same time. For 40 years, people people emerge from Liz's theatricals and novels and poems as if exiting dreams, shaking their heads and asking themselves, how did she do that? Because she was so prolific, it's tempting to believe it was easy that she lived in a state of flow. But that overlooks her astonishing work ethic. Liz knew just how much dissonance is encountered on the way to a resonant piece of art. Yet no one embraced the rigors of craft more ardently. And no one faced adversity and loss of which she had more than her fair share with more courage and grace. And she had a lot more to give. She worked right up to the end. Brilliant, interrupted. How will miss it, Lizzie and you? In the second nominee, our best musical, Runaways. This original moving and complex work is about children and parents and the runaway in everyone. And I know really what this means. Believe me. Ladies and gentlemen, the original Broadway cast of Runaways. I was sitting at the table with a trusted group of ideas who took my imagination past all who is some timeless and mysterious force of nature and a very practical organizer who was trying to get her next project done. Since her ideas had no precedent and were somewhere between street theater, opera, a consciousness raising group, and a homeless shelter, not to mention books of words and images for children and grownups, including one that made depression undepressing. This was never easy. Yet when her projects happened, no one left the theater or put the book down as the same person they were before. I always left her with feeling that my sense of color and texture had been heightened as if no one else's hair with that shade of red and no one else's tweeds and sweaters have the same texture and no one else's vibrations were as tuned as the guitar she played. I used to worry about her high level of energy. She was just on a faster timeline than the rest of us. And I feared she might burn out. I don't know if that's what happened. I do know that it is wrong that such energy and talent and kindness and creativity should have left the world, especially when she was a decade and a half younger than I am. It's not right. I can always suggest that each of us who loved her tried to take on an echo of what she saw and felt and felt in her and keep it alive at our dinners and in our books and in our theaters and in our activism in the world. Then she will be with us always now and forever more glorious item. It was an unrequited love. I don't have many prepared remarks because I wasn't sure what I was going to say today, obviously, and I thank everybody for mentioning me. I do have a team of people that worked with me at the hospital and Barbara Dopkin, Susan Whitehead and George Drans and Judith Ginsburg and Richard Sadowski who were my team at the hospital in the last few days. But I do want to talk to you a little bit about our relationship because people said, well, wasn't she working all the time and how did you ever have time for each other? Well, Liz found her way to work around my schedule. And often the only fight we would have is B830 in the morning when she wanted to compose some music and I wanted to watch Morning Joe. So it was only half hour. And then I left. Second thing that Liz always did was think my birthdays were the most important thing in her life as I did of hers. And for my 50th birthday, she produced and directed a film about me behind my back. And it was called Das Ros. It is available. And Das Ros had all my family, all my friends. And since I was named after Rosalyn Russell, there were illegal use of clips of Rosalyn Russell in her girl Friday. After the film, which was at the Tribeca Film Center, after the film, she had a Congo line of live musicians dancing in the street with my family, including my mother and my grandmother, and my sister, and my cousins, and many other people dancing down Greenwich Street to a restaurant where we had a party. For my 52nd birthday, because she was nervous that I thought I was getting old, she bought me a motorcycle. So I was tooting around Tribeca and Soho in a yellow Honda motorcycle, which wasn't frankly good enough for me. So I asked if she could get me a Vespa. And of course she did. For my 60th birthday, she took me on a world tour, only of Italy, which to me is the world. And we stayed in the fanciest hotels. And I went, really, we're going to be on the Arno, like really?  It is your 60th birthday. I can't say what the last year has been, except to say that Liz never gave up. Never. And I think before we knew we had a shot at beating this terrible disease, I want to tell you a little story of when we first got or Liz first got the diagnosis, and we also thought at the time that had metastasized. This was before we got the good news, and then we got the bad news. But the bad news had come very early. And we went to see her psychiatrist, of which, as anybody knows us, we had many psychiatrists, many psychologists, many coaches, many people who were on our team. And I was sobbing. And she was looking at me and looking at her doctor and said, I'm worried about her. And it was not only because she was worried about me. She was also saying that the we would never exist if she died. And that's what I'll miss. It's not that I can't go on, I will. But the we stopped. And for that, I'm deeply ungrateful. I loved her. She knew it. She loved me more than anybody else had ever loved me. And she totally got me. And so for that, I thank her for giving me an understanding of love. And what I can give to people and what she can give and gave to me the week. Thank you.