10 straight years of Tampa Bay Buccaneers football. Let's get it boys, as I'm recording this, the Lions and the Buccaneers have not yet played in the playoffs. But obviously the Lions are gonna win. Now this Buccaneers team is awesome. I really do like the team. But it would be really hard to win a Super Bowl with this team right now. And on average, we're gonna go nine and eight, eight, nine, maybe 10 and seven. And you kinda get stuck in this infinite loop of mediocrity. Cause if you're really bad, you get an amazing draft pick. And if you're really good, you go to the Super Bowl. But anywhere in the middle, you kinda get stuck. So the goal of course is to win a Super Bowl. Let's talk about this team. It's an 83 overall with 83 offense, 85 defense. A lot of our star players are older, regressing and on big contracts. So we'll definitely run into some salary cap issues too. We'll start on offense. We've got one of the best young offensive linemen in football, Tristan Werffs. He's gonna be a 99 very soon here, but he's already on a gigantic contract and it expires in two years. So we're gonna have to pay the big boy. Mike Evans is another guy. Mike Evans is a cornerstone buck and ear player, but he's 30 and in Madden past 30, you start to regress. He might not even have his Superstar X factor in a few years here. We'll see what we can do, Mike Evans. Rashad White, definitely the future running back here. Arizona State Sun Devil, he's star, he's 80 overall. He's got 90 speed, 92 Excel. I'm excited to see what we can do with him. Chris Godwin is awesome too. He's got another good three, four years to get a little bit better, but neither him nor Mike Evans are exactly young. Luckily we do have Trey Palmer. I don't know if you guys saw the stat, but every single day that Trey Palmer woke up and tweeted that he was pissed off, he scored a touchdown. So hopefully this is a pissed off Trey Palmer. He's really fast, 95 speed, 92 Excel. We'll see how it goes. The biggest question mark on this team is Baker Mayfield. Baker Mayfield, I love Baker. He was almost out the league and he just beat the Eagles in the wildcard playoff. That's amazing. However, from a Madden standpoint, he's 28 years old, five years in the league, he's normal deaf, meaning even if we get him really quickly to start at, he's already 29 and on the verge of regressing.  I mean, how old was Tom Brady when he won the bowl with the Buccaneers? Regardless, I don't know about Baker. We're definitely gonna trust in him this year and probably next year, but I think we should look to draft a young rookie quarterback as his eventual replacement. And on to the defense, where we have so many studs on this defense, there's only one starter who's not star or better development, which is insane. Our corners, Jamel Dean and Carlson Davis, both 26 years old, both on huge contracts. Probably my favorite defensive player on the Tampa Bay Buccaneers.  Antoine Winfield is a short safety, but he hits hard. He's 25 years old. He's started at, he's a 92 overall. He is gonna progress like crazy. I will not be shocked if he hits 99 overall, Superstar X factor. One important thing we gotta do with Antoine Winfield, we have to put him in at sub linebacker.  They're always in. And it's a really good way to get depth trade upgrades for them. So I want Winfield on the field at all times, no pun intended. Now, this is kind of like my problem point on this defense is Shaq Barrett, Levante David Vitavel. These are our Superstar abilities, but there's a good chance that even next year, none of these guys have their Superstar abilities or they're not on the team. Levante David is beyond retirement. He's 33 years old as a middle linebacker. I will be shocked if he suits up next year. Shaq Barrett is where our edge pressure comes from. Tampa Bay runs a three, four, which is perfect. You got Vitavel in the middle and then pressure from Shaq Barrett. But Shaq Barrett's getting old. Shaq Barrett is 30 years old. He's an 80 overall. That's probably not the future of the Buccaneers defense. What is the future? It's probably Joe trying to show you income. I like him a lot. He's 24 years old. He's a 75 overall speed rusher. He's got 83 speed, 86 excel. So we're gonna have to develop him. Hopefully we can get him some stats. And then Vitavel anchors the middle of this defense. He's 28. We probably got another good four or five years out of him depending on how long he keeps his Superstar status. He is incredible, but this is a 10 year rebuild. Then of course, there's Coligia Canzi, another good edge rusher rookie out of Pittsburgh. He's already a 76 overall speed rusher. So if I had to say our priorities for the upcoming drafts, definitely gonna start Cody Melch. I've got to get Ryan Jensen to start at center. I don't know why he's not in right now, but he's definitely on this team. Could definitely draft a guard. Could definitely draft a wide receiver. Eventually we got to draft a quarterback, but maybe not this upcoming one. We're gonna have to replace Levante David. Devon White will be a good replacement, but who goes behind him? We're absolutely gonna have to replace Shaq Barrett. If we're gonna run a three-four, we need two good edge rusher linebackers. Once Shaq Barrett's gone, we're not gonna have anybody. So I think my big priority right now is edge rusher outside linebacker from this upcoming draft. Before we kick off our very first year, let's talk about our schemes. I've elected to go Buffalo Bills offensive playbook, which is vertical power run. Tampa Bay offense is bad and the best offenses are Kansas City and Dallas, but every single rebuild would be the same if we always ran Kansas City Dallas. So I'm trying Buffalo. Vertical power runs a pretty good scheme fit for this team to 70% and we will stay in the base three-four Tampa Bay Buccaneers defense. It's so perfect for this team, but I think our upcoming drafts will determine just how perfect it is. All right, boys, let's kick it off. Year one, let's see what Tampa Bay can do. And that's when disaster struck. I am so sorry, boys. I spent about eight hours on this video and I lost the footage from year one, year two, and year three. And the next seven years of footage from years 2025 to 2032, my audio is so scuffed. I am so sorry, but I'm gonna try and salvage this video. Let me give you a quick rundown of 23, 24, and 25. And I'll see you guys at the start of 26. I really apologize. I won't let this happen again. I hope you still enjoy the video. In the first year, we went six and 11. Deck Prescott won Super Bowl MVP and NFL MVP. Sure, Madden. They beat the Ravens. Rookie of the Year was Rache Rice, defensive rookie of the year, Brian Bresi. In the upcoming draft, we drafted Nigel Bradsen, a right outside linebacker, to replace Jack Barrett. He ended up being a solid player, but he was normal death. So in 2024, Josh Allen wins Super Bowl MVP. Deck gets back to back NFL MVP and the Bills beat the Rams. In 2025, we drafted a left-end Dante Nix and he ended up winning defensive rookie of the year, getting seven and a half sacks. He was star dev and he went up to superstar because of that defensive rookie of the year. Raiders win the Super Bowl and the MVP was a rookie middle linebacker, Zach Bolin. We made it to the wild card playoff in this season, but we lost in the first round. So in those first three years, we made the playoffs once. We lost. And now I'll have you guys take over. I'm really sorry about the audio. Hope you guys can enjoy. I won't make this mistake again. I love y'all. Peace. Midway through season three, we are not looking good. One in five is definitely our worst start. Lost to the Seahawks. We beat the Dolphins and we lost to the Bills, the Jaguars, the Rams and the commanders, 39 to 53. Oh my. This is actually pitiful. We were horrible defensively. Our offensive rush game was horrendous. Our passing was pretty solid. Yikes. I'm honestly shocked. I felt like we were in a good position this year. So Baker was seventh in the NFL with his most passing yards so far. 30 and 15 is not good. 15 interceptions is actually nuts. Baker only got better and he regressed. 30 and 15 is really bad actually. You've got Mahomes is 44 and 12. You've got Sam Howell at 39 and seven. You got Quinton Billingsley at 33 and 15. 31 and five is Hertz. Yeah. I mean, he's up there in passing yards, but he's getting outplayed by rookies. Rashad White with a mediocre year here. Receiving Chris Godwin had a really big season. Downs had 1092 and four touchdowns. Groves, 664 and eight. Gosh, I'm honestly just worried that, you know, Godwin is now gonna be on his ninth year and then Baker's getting older too. I think it might finally be time heading into year four to get a new quarterback. Indefensively, this wasn't a great year either. Potential defensive rookie of the year. Seven sacks isn't a ton, but Dante Nix had a really good season with seven sacks. I'm happy about that. Trojanke had five and a half, Dodson with three and one and a half for Dion Brown, one for Devin White, Isian Logan Hall. Interceptions wise, we had four from Jamele Dean. Nice. Two Carlton Davis, one from Dion Brown, one from Winfield. Yeah, honestly, I don't really know what happened. It was just a horrible year for us. That's the offensive rookie of the year. It's like Pat Kindley came in sixth. He was our backup running back. I'm surprised that he's even on the board. Defensive rookie of the year is gonna go to Dante Nix. That's actually massive. Hopefully he gets it for the whole league, but at the very least he'll get it for the NFC. That was a very good draft pick. I'm still happy about that. Damn, okay, bummer year. Let's head to the off season. We do have some salary caps, so we should be able to make a move in free agency. Gosh, I feel like I need to pick up some defense. So Raiders beat the Cowboys 27-17. Super MVP is Zach Bolin, who I assume is a auto-generated player. Defensive rookie of the year of the entire league is Dante Nix with only seven sacks. So it must not have been a very strong year for rookie defensive players, but I'm totally happy with that, which means he got a DevTrate upgrade. So if he was star, he's now a superstar, but if he was superstar, he's now X-Factor. Okay, so taking a look at this season, looks like Chris Godwin got his DevTrate re-upgraded to superstar, so good for him. Downs and groves kind of had off years. Rashad Wright was okay, Kindley is star. Levy is a star left guard, so that's good. Worfs is still looking really, really good. And then defensively, Dante Nix. So, oh wait, we got a lot of DevTrate upgrades. Jamel Dean got one, Ryan Neal regressed. Devin White went up to superstar, so that's really good. Winfield's superstar, and then Dante Nix. So Dante Nix was a star Dev player, now he's upgraded to superstar. He gets two power rushers as well. Dante Nix is gonna be really, really good. Yeah, honestly, this defense looks really, really good. I think we just need to consider moving Baker. Which is sad, but I think we gotta consider it. At least finding his replacement. All right, free agency. We have 55 million caps, so that's really, really good. There's a 35 year old Aaron Donald. Obviously he's really good, but I just don't know. Do you sign him for a year for 29 million? I don't know if that's worth it. I just don't feel like we're ready to really win a Super Bowl, so why would we do that? We're not in a position to even sign free agents. Why would I sign Aaron Donald for one year? Just to go middle of the pack again. I'm not gonna sign anybody. We're going straight to the draft, and we've got a very high draft pick since we went three and 14, so we should get an absolute monster here. Hopefully a quarterback. Well, I have good news gentlemen. We were so bad this year that we have the very first pick. Usually these are deep QB classes, but this one actually isn't. There's only two quarterbacks that are going in the top 10. There's Anthony Wall out of Auburn, and there's Eric Hoyer out of Baylor. I've scouted both. Eric Hoyer is a lot better, so the mock draft is exactly what I'm gonna do. We just gotta hope this guy's a dog, and this is Baker's future replacement. Maybe I'll start him this season. Maybe not. It's hard to say, but it is pretty easy to make your pick when you're round one pick one, and the best quarterback is sitting right here. I'll let you guys take a look at him. So Eric Hoyer, he's a field general out of Baylor. He's 22 years old, great throw power. That's really, really good. Solid speed, great change of direction. The rest of those intangibles aren't the best. So I have a feeling this guy's not generational by any means, but A, medium accuracy, A short, B under pressure, B deep. He's definitely gonna be just like a solid quarterback out the gates, and yeah, he's round one pick one. We're gonna get hit and have 87 change of direction, 85 excel, 92 throw power. Eric Hoyer, you know what's funny? He kinda looks like a poor man's Baker Mayfield, a little bit. He'll fit right in in Tampa Bay. And our next pick's not till the fifth round. I'm glad we hung onto our first round in this draft, and we can advance to the end. Let the CPU take over. Draft recap, oh my goodness. Dude, the CPU auto draft has been so solid. They got a 72 overall tight end in the fifth round. That's actually really solid. I'll put him in behind K. Dotten, and then Eric Hoyer is a 74 overall. Yeah, he's not generational, but 74 is a great starting play, especially because he's hidden dev. He's round one pick one. So not the worst chance of him being superstar, but he's probably just star. 82 speed, 85 excel, 88 short, 86 mid, 78 deep. This guy's a stud. Dude, these throw power and short and mid. Just gotta work on his deep accuracy, yeah. Hey, Eric Hoyer, that's the future of this franchise, I think. I'm excited. Looks like the best player in the class. Ooh, there was a generational free safety, Junior Singh out of Washington. 81, he was the last pick of the first round. There was a 78 corner, 77 hat back center detackle, but it doesn't look like there was a better quarterback. So we did make the right quarterback choice. Baker's in his eighth year, Hoyer's already a 75, and he's got a really good chance at offensive rookie of the year. I am gonna move Baker down in the depth chart. I might even trade him right now. I am moving Kevin Tiller to my backup tight end. Dude, can we give it up for the computer? Kevin Tiller is hidden dev.  The Utah State rookie tight end.  It's a 10-year rebuild. All right, this Buccaneers roster is so lopsided. 91 on defense, 84 on offense, but that's cause we've got the rookie starting. Let's see how he's doing halfway through the season. Oh, wait, wait, wait, wait. I gotta trade Baker while he's still got value. Oh my God, look at the trade offer we just got for Yaya Diabe. Someone's offering a superstar tight end who's 22? Titans are offering, oh my God. The Raiders are also offering a superstar tight end, Jeremiah Ambrose. Dude, this is like the deepest tight end class I've ever seen. And then a center bow tranquil in some draft picks. Okay, so do we take Doug Matthews or Jeremiah Ambrose? I'm taking Doug Matthews. I don't even use Yaya. We've now got three. Oh my God, wait a minute. Wait a minute, dude. So Doug Matthews is a blocking tight end? Well, no wonder they wanted to trade him. This is a weird tight end, but I'm still gonna rock with him, dude. Oh my God, he has 74 speed, 80 XL, 80 impact block. Of course you wanted to trade him away. I mean, I didn't really get flased. He's kind of a dog. How could we use a blocking tight end? What laybook would actually use this? Bills does kind of use this, but they also throw to their tight end. So dude, I'm about to create the greatest blocking tight end of all time. Doug Matthews is definitely a starter. The Jets are heavily interested in a veteran quarterback. You think I could get 96 Breeze Hall, 25 years old for a veteran baker and kindly? Now, just in case that's actually such an enticing offer, I'm gonna throw in a first and second round draft pick. Oh, salary cap. Nevermind. Ooh, Seattle's interested. 99 overall, Kenneth Walker. Oh, would they do this? They wouldn't do this. Oh my God, we're not that far off though. We could get a 99 halfback. What if I just gave him Rashad White? Kenneth Walker is younger and higher overall. Oh, no, I could have put a draft pick in there. Oh my God. Baker and Rashad White are headed to Seattle for 99 overall, 25 year old Kenneth Walker. He's still got four years left on his deal. Dude, we just gotta get Walker to superstar. Five, nine, 25 out of, of course, Michigan State University. 96 speed, 97 Excel. He's a stud. He absolutely is going for at least 1,000 yards this season. Mid-season, we are two and five in year four. It's actually better than where we were last time and we got the rookie in. All right, let's head to the playoffs. We probably don't make them, but we get offensive rookie of the year. Josh Downs develops, Kenneth Walker develops, and hopefully we'll be ready to win something in an upcoming season here. Well, six and 11 is an improvement no matter what they say about us on Twitter.com. The question is how did the rookie perform? He had 3,824 passing yards, but you know what's crazy? He had virtually the same touchdown and reception ratio as Baker did. He actually had a slightly better. So he didn't get the yards that Baker got, but already in his debut season, I think he's headed for greatness. Kenneth Walker, 1,311 amazing season for him. We knew that was gonna happen. And receiving Josh Downs as the leader with 1,112 touchdowns. Godwin, 9,16, and nine. He's definitely getting to his last legs. And Christopher Groves, 8,37, and two. Even Doug Matthews, the tight end who's known for his blocking went for 483 and four. Solid, solid season. Defensively, Devin White, almost 140 tackles. Deon Brown, 130. Dodson with 90. Our sack numbers are, ooh, nevermind. Dante Nix is becoming a dog. 13 TFLs and 10 sacks is a really good season for Dante. Five and a half for Vita Veja, four for Shoyinka, three for Colesia Kansi, Nigel Dodson, who we drafted a while ago really hasn't done much. I might consider switching up my defensive scheme and then interceptions. We got three for Winfield, one for Devin, one for Carlton Davis. Is that offensive rookie of the year numbers? Yeah, Eric Hoyer's not gonna get it. That's a bummer. Greg Cox is gonna get it. I don't even know what position he is, but good for him. Oh, look at this. 2026 Super Bowl was a rerun and the Chiefs won it again. Armand Cheeks won defensive rookie of the year. Oh my God. Okay, headed into free agency. We clearly need a center since Ryan Shanson retired and we need a right tackle. Kevin Tiller is a superstar X Factor. This was the fifth round pick by the computer. Okay, we have to change something. We need a tight end dominant playbook. We have two insane tight ends. Godwin's regressing. Hoyer is a star dev 82 overall. We've got to sign a center and a right tackle in free agency. Defensively Vita Veja regresses. Nix is still X Factor. Kansy looks good. Linebackers look great. Ooh, Winfield's up to X Factor, but we lost Ryan Neal. So we've got to sign a strong safety too. I need to show you guys something though. At first I was like, did I accidentally put tight end draft class strength on Super Strong? Nope. I am normal draft class strength on everything. These are just the most astronomical tight ends I've ever seen. Whatever, man. I'm not gonna complain about it. So we have a high draft pick and we've got a good amount of cap space. This could be a really, really good season for us. So look at that. Sam Laporta 94 overall is in free agency. Tyree kills in free agency. We don't need him either. Looks like we could pick up Tevin Jenkins. Let's try and get him on a four year deal and I'll move Jenkins probably to a right tackle or center. It's a really strong offer. He should accept that. And here's a good option. Nicholas Petit Freer. He's only 27 years old. He only wants a one year deal, but I would like to have him for a lot longer than that. He's a solid 79 overall and he's 27 years old. So he's got a good four years in him. Yeah. There are no good safeties available in this free agency class. Let's just take those two. Dude, I just realized too that since Doug Matthews is an insane blocking tight end, he's also probably an insane fullback. We'll get tiller to starting tight end and my backup can be Kate Odden and then Matthews can be fullback. Everything else on this old line looks so much better now that we got Tevin Jenkins and Petit Freer Jenkins at right guard. Petit Freer at right tackle. Mouch is at center. Levy who we drafted at left guard and Worfs is obviously still amazing. So offensive line looks really, really good now. And then defensively, we just got to draft a safety because we got KC, we got Nix, we got Vitaveya, then Dodson and Shoyinka, Winfield, Jamal Dean. Yeah, we just need a safety. We have round one pick six. This might be a pick that we trade down from unless there is a really monster safety just sitting here. But I don't know. There's usually not safeties at this high. Where do I just take him right now because I know he's probably our guy. Luke McLean looks nasty. A man coverage, B play rec, A hit power. He's a strong safety, elite speed.  Yeah, I could technically have traded down since he was 13th there, but there's no reason to risk it when he looks that good. Five, 10 hybrid safety out of Cal, 93 speed, 92 Excel. And he's hitting death. That's literally exactly what we needed. The rest of this draft could go poorly and we'd be just fine, but I'm still gonna draft because I'd love to get some more studs. Round two pick six. I think we're gonna need to eventually replace Vita Vaya. Vita Vaya is gonna be the next guy that retires on this team. It's pretty tough to get good D-tackles. We can give it a go. This is a run stopper left end who definitely could play D-tackle. We could switch him over. Elite strength, marginal speed, great Excel. That is a weird player, but you know what? He's 301-66 run stopper. I'm gonna take Sean Mitchell. I got a little cocky after my last good pick. He's normal dev. We'll see what Sean Mitchell pans out to be, but worst case scenario, I could move into D-tackle and he could replace Vita Vaya. No third or fourth round or we traded those earlier in the season, so we'll sim to the end. And honestly, I know the CPU is cracked since they drafted me a X-factor tight end. Draft recap. Luke McLean, 80 overall. Is that considered generational? I don't know, but he's 93 speed, 92 Excel.  This dude is a beast. Sean Mitchell's a 72, that's really not that bad. Computer got me Boswell out of Michigan State, who's a 71, a 70 D-tackle, and a 64. It's really not that bad. We might've got the best player in the draft. Let's find out. Best player in the class is Luke McLean. Let's go. That's so sick. It's the only position I needed to. Chuck Money is the next best out of Oregon, 97 speed, Jabari Burley, D-tackle out of Virginia. That's, oh, that feels so good. All right, boys. Season five, we're looking really good. We've made the changes we need to put this team in the right spot. We've got young new offensive players. We've got an awesome young tight end. Josh Downs and Groves are our young wide receivers. Kenneth Walker's a 99. Hoyer, obviously, our second year quarterback. We've got Deion Brown. We've got the new Luke McLean, the best player in that draft class. Winfield's a hard 99, but he's gonna regress. He's getting old. Same with Vita Vaya. Vita Vaya might be on his last legs here. So if this is gonna be a really, really good season, we have a chance for the Super Bowl this season, but we have a really good chance next season too. So let's just see what we can do. And it looks like we have a trade offer for Deion Brown. Oh my God. They're offering Trayvon Morig, a fifth and a seventh for Deion Brown. I like Deion Brown though. I don't know if I really wanna part ways with the boy.  We're getting offered a Superstar 24 year old corner Terrell Harper for Deion Brown. We're getting offered Jordan Davis. What are these trades? This is some casual ass, okay, I did whiff on that one tight end. I think we take the corner. I like Jordan Davis, I do. He's that Vita Vaya replacement. Gosh, a Superstar corner. Jamele Dean's getting old too. I'm taking Terrell Harper. Let's trade away Jamele Dean though, because we just got a super good, super young corner and now we've got so many corners. Yeah, Jamele Dean is 30 and he's star. He's still good though. Like there's definitely gonna be teams that want him. Raiders look like they need a corner. I wonder if I could get Max Crosby off of them. Jamele Dean and my first round pick for Max Crosby. My pick has really high value because it's round one pick six technically but we're gonna have a really good season. So I think let's make sure I don't fleece myself. Let's throw in their second round pick. He's just got 99 Max Crosby.  Oh my God. All right, so we have no round one in this upcoming year but now we have Max Crosby, Dante Nix. Without Deion Brown, we do have a little vacancy here at our backup middle linebacker. Right now it's favors but we do have a hidden Devonade and Spruce. So let's throw a Spruce in there. Let's take a look at Terrell Harper. So we just got Terrell Harper, two-year player out of Washington State, 92 speed, 92 man, 92 excel, decent zone coverage. And he's already super star is so crazy. Doesn't have the best abilities. Give him unfakable and it's okay. Good Lord. All right, well we gotta win a Super Bowl in the next two years though because we have Max Crosby for at least two years and he'll be a 99 for that time period. So let's see how this regular season goes. Oh, we're back. We're back in the playoffs at the nine and eight seed. Here we go. Let's take a look around the league. Hoyer, 4,000 passing arts, seventh in the NFL, not bad. He threw 30 touchdowns, eight interceptions. And for some reason Carlos Cardona came in, he threw two. NFC offensive player of the year, Kenneth Walker. That's awesome.  Defensive rookie of the year, none other than Luke McLean, offensive rookie of the year. I don't even think we had anybody. Yeah, we didn't have anybody that could have gotten that. Dude, our trades, our trades are looking strong. So Walker had, whoa. Oh my God. Okay, he's definitely going to superstar.  That might be the best running back season I've ever had ever, 1,743 and 21. Are you kidding me? Otten, what? That's not right. Oh no, I think I accidentally started Cade Otten. It's not a big deal but that definitely should have gone to Tiller who's the superstar X factor. For Kevin Tiller, our superstar X factor to actually sit here with one reception for five yards is so sad. So I definitely messed that up. Josh Downs gets 9, 49 and nine. Groves gets 7, 75 and five. Godwin, 6, 32 and six. Yeah, that's a bummer. I shouldn't have, Cade Otten should never be our lead receiver. I don't know how I did that, but I goofed it. It's like we didn't play nearly as much defense but I suppose we were actually winning games. We had 17 and a half sacks out of Crosby, nine out of Nix and eight and a half on a show, you ain't got six out of Ita Vela. And Carlton Davis had five interceptions. Luke McLean had four and three TFLs in a sack. No wonder he won it. Three for Winfield, two for Dodson, two for Terrell Harper, the newbie. All right, nice work boys. Really good season. Wait a minute, wait a minute, wait a minute, wait a minute, wait a minute. Oh no, we didn't make the playoffs, my bad. That didn't make any sense. I almost just thought we had to buy in the wild because we actually didn't make the playoffs. That's kind of a bummer but we are in such a good position next season because Kenneth Walker's getting an upgrade. Eric Hoyer will probably get a DevTrade upgrade and this team's gonna look monstrous. Luke McLean, was he Superstar? And then he got X-Factor, what happened here? No, there's no DevTrade upgrade in here. defensive rookie the year gave him a bunch of XP but it didn't give him a DevTrade upgrade. So he was out the box, Superstar X-Factor. We have now drafted two Superstar X-Factors, one personally and one by the CPU. Okay, in this upcoming draft class we gotta get ourselves a center. Potentially could grab a wide receiver and defensively I really don't even think I could do a single thing to improve it. Actually no, I'll back up in a linebacker. We've got some targets in the draft here. We don't have a first round pick but we do have two second round picks. Montel Singleton has great speed, elite acceleration, good and everything else. Oh sorry, Montel Singleton. He's normal Dev deep threat, 93 speed, 94. So he's got good stats, just as good as we were hoping. We have two second round picks. So we'll be able to kind of go for a little back to back here. I do need that backup middle linebacker. Could always draft an outside linebacker and move them. We also could take Wendell Williams here. Great speed, solid strength, great Excel. I'm gonna do it. I'm gonna take Wendell Williams, hidden DevTackle. This will be an excellent replacement for Vita Vaya who's definitely gonna be out of here soon. He was an X-Factor two years ago. He's star Dev right now. That's how quickly he's regressed. Now let's pick up that backup middle linebacker in the third round. Tanner White, field general middle linebacker. He's fallen in rank but he's got a lead agility, great speed, great jump, great Excel. Tanner White kind of looks like a stud. Yeah, he's a normal Dev but an 88 speed, 90 Excel, field general out of Iowa. All right, I'm very excited about that. He'll probably be at least a 69 overall I'm hoping. Year five is now in the books. Year six, we've got Max Crosby. We've still got Vita Vaya. Our young quarterback's looking really good. I think this is our season to really make a Super Bowl push. Singleton's a 71, Williams is a 72, White is a 70. This is probably our worst draft so far. Sorry, yeah, this was not the one, the best player in the class. What the, what? There's an 85, an 83, and an 81. Lonnie Morrison, how are you an 85 overall? 92 speed ace and break tackle. Damn, 99 juke move, a generational halfback. All right boys, it's a make or break season. Max Crosby's on his final year. He's about to turn 32. Vita Vaya is regressing, but we've got 99 overall Kenneth Walker. Josh Downs is a 94. Oh, I'm nervous.  Dude, what? Who did we even lose to? So Hoyer is a 97 star Dev at this boy. Healer's an 88. I wasn't able to get my hands on a center. I did forget about that, but you know what, it didn't matter. Our 74 overall, McGee got the job done. Downs is up to a 99. Weldon and Godwin are hanging on. We're gonna need some wide receivers in the future here. Vita Vaya's on his last legs, but Wendell Williams is ready to replace him next season. Crosby's got upgrades. McClellan's a 97 in year two. It's disgusting. Tanner White looks like he had a solid season. Shoyinka is superstar. Yeah, we are chillin'. We are chillin', boys. This is our best season by far, finally. Hoyer is fourth in the NFL in passing arts 34 and two. That's almost probably an MVP season. Walker, another amazing season, 15, 75, 21 touchdowns. Taylor at 1066 and 11. Downs at 1041 and 11. Weldon, 948 and five. Marcus Weldon, Chris Godwin, 712 and three. Kenneth Walker had a lot of receiving errors. So Marcus Weldon came in to replace Christopher Groves. Christopher Groves wanted a mega contract and I just couldn't afford it. So we ended up going with Marcus Weldon, who was like a deep pick by the CPU a few years ago. Works out for us defensively. Devin White has been an anchor on this team for so long. Great work. Tanner White with the second most tackles. Sacks, 18 Crosby, 12 and a half. Shoyinka, 11 Dante mix.  Interceptions three for the goat, Luke McClellan. One for Tanner, one for Carlton, one for Terrell, one for Winfield. Literally absurd season. This has got to be our Super Bowl season. All right, our divisional game is against the Panthers and NFC South rival 11 and six. I'm going to step in and play a little on offense and a little on defense, but I don't want to like actively really impact this game. I'm going to put on the creamsicles baby because I'm wearing them. They still got Bryce Young, Eric Coyer trotting out there. So there's Tanner White and there's Devin White. Oh my God.  Does that make any sense? Okay, whatever. We got the White duo.  Got Juan Jefferson coming over and guess who? Try on Shoyinka. We're going to go mid blitz here and I'm going on the goat, Luke McClellan. Look at all the abilities on this defense. Get home, Max Crosby almost smokes him. I'm going to run that same thing.   This team is so nasty. All right, where's McClellan? Oh, he tries to hook one deep. Intercepted, it's one winfield. It's Julian Jefferson. Sorry guys, there's a lot of players. That was open too. That deep route was open, but luckily we got to him. This D line is so impressive. It took us six years, but this could be a serious dynasty. All right, let's see where we start. Looks like we got a cross or out of Josh. Oh, Matthew. Oh no, I need it. Oh my God, and he's spinning on me. Damn, I thought that was open, but I didn't have the zip that I needed. I can't have any more impact. That's an offensive and a defensive drive. I gotta go. All right, Carolina's got six, Tampa Bay's got seven. Now 14, now 21. Shit, they're a lot better off without me. 21, 12, 29, 12. Let's check in for a few of these final plays here. Third and seven.  We got this 99 hat back, and that's exactly what we're gonna do right here as we take a cake walk over the Panthers. Walker goes for a few. We're gonna punt this away, but that's the ball game. We gotta get this super. Dude, let's build the dynasty right now. Let's go. NFC chips coming up. Ooh, taking on San Francisco who's 14 and three. Let's play ball. Niners start on the board. I'm gonna step in here with Kenneth Walker and maybe put us on the board ourselves. Good stiff arm, but we're down to the four. Let's just go back to the stretch. They can't stop the stretch here, can they? We'll go bench. Gotta look at the boy, Kevin Tiller. He's too hot. What do we got, Hoyer? This is a big down for us. There's Kevin Tiller. Dude, he's a dog. He's so good. All right, touchdown Buccaneers. Now we got a big third down stop. I'm gonna step in with Devin White and Tanner White. Third and three. What are they going for? That's to McCaffrey. Oh, I missed. I was so close to that, but that's all right. We got a third and 10 now here. Max Crosby gets home. We got this. Ooh, great defense. We don't need Max Crosby because we got Dante Nix. Great stop right there. I'll take over once more in the red zone and this will be my final input on this game. I gotta let the boys take over after that first and goal.  No doubt. Where are you blocking? Oh, doesn't matter. Kenneth Walker's insane. All right, here we go, boys. Tampa Bay 14-7. Now 21-7. Oh my God. We're really just steam rolling. Wait, 28-14. Oh my God. 45-14. Brock Purdy is desperately trying to put some points up. I respect that. But dude, this game is cooked. It's cooked. George Kittle, maybe it's not cooked. Luke, you better track him down. That's my X factor. That's my Luke. They're not calling timeouts. They just want the touchdown. It doesn't really matter to them if they get it quick or not. Quick pass going nowhere. This game is over. What a game for Eric Boyer. Almost a perfect passer rating. 23 for 27, 280. Four touchdowns. Walker, 14 for 68. Luke gets an interception. Two sacks for Max Crosby. One for Wendell. One for Dante next. One for Viteve. A big dub against the Niners. We're on to the Super Bowl, baby. Finally, year six may be our first Super Bowl. We're taking on, oh my God, the 14 and three Baltimore Ravens. Look at this. All right, boys, let's see what we can do. Tampa Bay's first Super Bowl under new management. I appreciate all the fans for waiting six years for this, but I think it's gonna pay off because we might have just rebuilt a serious dynasty as we start the Super Bowl with three. Baltimore gets three than 10. We get 10 of our own. They get seven. We return with three. We return with seven. Let's check in. A three point lead in the third quarter of the Super Bowl. We've got the ball. Let's go, Tampa Bay. Dude, I love these cream school units. They're so sick. Ooh, fakes the handoff to Walker throws a sketchy pass. Third in two. Dude, literally just feed Kenneth Walker until this game's over. That was the best trade we made, I think. I don't know. I guess Max Crosby did have 18 sacks this season. Oh my goodness. Can we actually run out this clock in the bowl? A touchdown here might seal it. Hoyer, Hoyer's sacked. Odafe, oh wait, has two and a half sacks today. Second and 18, we go for the handoff here. Interesting, make it third and 11. It's a big pickup though. All right, five wide, empty backfield. Eric Hoyer, I'm getting Brian Hoyer flashbacks. It's his son. Oh my God, these Blitzes are nasty. Marlon Humphrey comes through the middle and we're punting the ball to the Ravens here. Yikes. Baltimore digs themself a hole. On their ensuing drive, it's fourth and 16. They have to go for it. This is the ball game. Pressure, collapsing, swatted. Look at that defense. Tanner White, I think was in his face and the swat down comes in. Is that the bowl? Oh, it kind of is. Tampa Bay's in range. There's two Baltimore timeouts. They really just need a first down and it's over. You can kneel it out.  Second and three, handoff Walker. He's not there. This would end the game. If they don't get it here, they're gonna have to take a field goal counter. Play action. Psychopath, play calling. End zone. Josh Downs just iced the Super Bowl.  Dude, I thought it was a handoff. It should have been.  Baltimore does march down and score but soon as Tampa Bay gets the ball back, it's all over 27 to 24. Eric Hoyer is a Super Bowl champion. Kenneth Walker, Max Crosby and shout out to the OG Buccaneers. Vita Vaya, Chris Godwin, Antoine Winfield. Tryon Shoyinka, Tristan Worfs. Honestly, a super good duel in the Super Bowl and it was a great game too. Hoyer did throw an interception but honestly, Kenneth Walker took that game over five and a half yards per carry in a touchdown base mode. Dude, look at this free agency class.  So there's Max Crosby who obviously is heavily interested in resigning with us since this was his last season but we did just win. Dude, there's two 99 X Factor quarterbacks, Dylan Pittman and Josh Allen. There's some great offensive linemen. Larry Vareen, 93 star and he's young. Carl Aftis is in there, McCaffrey's in there, Nelson. Okay, well let's try and re-sign Crosby. He'll play for three years. So obviously regressed but he's still really, really good. We'll give him a player friendly deal. He's gonna re-sign with us. I even could save a little bit of money here but I don't wanna risk him going to a different team cause he's gonna get a lot of offers. So just give him a player friendly deal. Hopefully he re-signs with us. Yeah, the Raiders are giving a pretty big offer ironically. Vareen doesn't look like he's gonna sign with us. I do kind of need a center or somebody that can play center. Jermaine Wagner, 87 overall star, he's interested. I'm gonna give him a player friendly and that's pretty much it for Capspace. So those are the only two signings we're gonna make. We don't get Max Crosby. Shit, Crosby goes to Vegas. I really did want him. Maybe I go for Carl Aftis now that we don't have Crosby. Damn, losing Crosby is a huge hit to this team. So we do get Wagner, we boost the outline. Damn, I really did want Crosby though. I'm gonna go for George Carl Aftis here. I'm gonna give him a player friendly, increases salary, trying to get him for four years. He'll be 32, which is how old Crosby is right now. See if we pick him up, we do. So we get George Carl Aftis and Jermaine Wagner in free agency, we lose Max Crosby to Vegas. Yikes. All right, well in the draft, we're round one pick 32. We're really deep down here. We've already replaced Vita Vaya. We really need a wide receiver. Here's Thomas Hackett out of Penn State with elite speed, change of direction agility and great Excel, great jumping. If this dude is not Hidden Dev, I don't know what to say. That's exactly what we're looking for. So Josh Downs is still really good, has some years left. Godwin's about done. A five, eight, one, seven, five, small wide receiver, but Hidden Dev with gnarly stats. That's exactly what we need. There's really nothing else I need significantly. So I'm gonna let the CPU take over on this one. Think next season, I might even consider trading my draft picks because I feel like the value we could get to be higher, we're rebuilt. We have a young quarterback, kind of just need cap space. Really, we're running on a cap though. We're back down to 6.8 million available cap space. So it's gonna get a little spooky. We'll take a look at the 2029 draft recap where we land a 75 overall Hidden Dev wide receiver. CPU grabs me, normal Dev left tackle, but that's okay. And the rest of these are criminal whiffs by the CPU, but I can't be mad. They got me the X factor stiller. Entire NFL, the best player was a quarterback, Paul Logan out of Auburn went to the Lions and then Dalvin Semple middle linebacker went to the Chargers 81 overall. Solid class. Hoyer is now a superstar. Offensive line still looks amazing tiller, 87 overall. Downs is a 96. We've got our new wide receiver Hackett. Chris Godwin did for Tyre. And then Singleton's our wide receiver. Three wide receivers don't look as good as they have been, but I think Hackett's gonna have a big season. I've got him at slot wide receiver. We've got Carl Aftis, Vita Vale officially normal Dev. It's time to start Wendell Williams. Wendell, since he didn't do anything last season is actually normal Dev. So he regressed. Nix, 96 overall, that was such a good draft pick. Harper regressed sadly, but we still have amazing corners. McLean, still X factor. Winfield still X factor. Looks like the CPU did get a hidden death in those 66 overall. Devin White regressed a little bit. Shoyinka went X factor. Then we got Tanner White and Dodson. Team looks amazing. Absolutely ready to go win some ball games. I don't think we go 16 and one again because we don't have Max Crosby. I feel like that Max Crosby was a big difference maker but I still think we have a good shot at the Super Bowl and we should certainly make the playoffs. So let's see how this follow-up season goes. I'm looking for offensive rookie of the year. All right, so we go 10 and seven. We don't win the NFC South. That goes to the Falcons. We're taking on 99 overall X factor Pukinakua but we heard a 95 overall normal draft classes in year seven. That's pretty awesome. This is one of the better rebuilds I've ever done. So I'm really happy with how it's gone so far but I want to get a second Super Bowl for sure. Let's take a look at how we did this season. Looks like we didn't do exactly as well as I was hoping. We get fifth in the NFL in passing yards, 28 and six. Walker, 1520, good Lord. He's been so insane since we got him. Thomas Hackett, those look like offensive rookie of the year numbers. I'm hoping 1106, Taylor, 945 and eight downs, 807. Singleton, 768 and two. Then Kenneth Walker with good receiving yards once again. So defensively, how are we looking? Devin White, the anchor. Every single season he's had the most tackles. Tanner White's getting close though. Yeah, we did take a regression to sacks department. We have three guys in double digits. That's awesome. Dante, Nick, Shoyanka and Vita Vaya still. Damn, Vita Vaya. You didn't even start. I guess Vita Vaya was probably my rush de-tackle. That's why. Carl Aftis had five but yeah, I mean Max Crosby had 18 and a half. That's a pretty big difference. Not a lot of interceptions this season. Two for Winfield, two for Davis, two for Harper and Luke McLean does get one. Okay, he's got at least an interception every single season. All right, let's see if we make it through this wild card. If we do, we can check in at the divisional. Wow. In our follow-up right after the bowl, we lose to the Rams 34 to 28. That's what I honestly thought that was gonna be a cakewalk. Year seven unfortunately, couldn't back to back the Super Bowl but I do have an idea. We're gonna have some decently valuable draft picks since we're 10 and seven, not 16 and one. I think we gotta go ahead and get a guy just like Max Crosby. I know we just signed George Carl Aftis but without abilities, he's just not Max Crosby. So I think we might go ahead, trade George Carl Aftis and some draft capital and get ourselves a Superstar X Factor monster edge rusher. And we don't need a guy that's gonna stick around for too long. Once again, we're ready to win a Super Bowl right now. Let's just add a crazy defensive piece. I should be enough. So after the season, Vita Vaya officially retires so it's all Wendell Williams here on out. Carl Aftis is a 94 star. I think I am gonna trade him. I gotta get a guy like Max Crosby. That was our recipe for success and we lost Crosby to Las Vegas. So let's see who we can pick up in his place. Honestly, I don't even have the cap space for this. I think we just gotta rock with this team and I don't know, maybe it was just an off year. I felt like this is still a really good team. We just had a bad year. Round one pick 20. What can we get out of this? Potentially a edge rusher of the future. I guess I'll go eight in Hayes but I don't think this dude's hidden div. Ooh, clutch, eight in Hayes. Big clutch, 87 strings, 76 XL, 66 speed, whatever. Tristan Werff's future replacement. The 10 year rebuild, we gotta think of everything. Aiden Hayes was only a 71. Dude, why are these the greatest tight ends of all time? Alani Johnson, 78 overall. Hidden Dev, Oklahoma State tight end with 88 speed. Dude, what is going on? I've never seen this, bro. It's abnormal strength. Take a look at the whole class. Best players of 79 overall. Literally the CPU just auto drafted me the third best player in the class in the third round. Alani Johnson out of okay state. Dude, do I put him in? Do I trade Taylor and put him in? I got too many good tight ends. This is crazy. We are negative on cap space though. We are hurting. Yeah, we kind of got a winner right now because I really can't make any trades. We have no cap space. The year is 2030, boys. Let's see what the Tampa Bay Buccaneers can do. We won a Super Bowl. We made the playoffs and lost in the first round. Now what do we got here? Dude, there's just something about being nine and eight that the Tampa Bay Buccaneers absolutely love. I have been nine and eight so many times. In week 18, we just lost to the Falcons and now we take them on in the wild car. There's absolutely no reason for us to change anything. Eric Hoyer has certainly come a long way. The Baylor quarterback's got kind of looks like a Josh Allen. He's got the speed and the Excel. He doesn't have the throw power though. Kenneth Walker is still rocking a hard 99 Superstar X factor although he's lost one speed. So he's definitely getting older. Taylor is almost a 99. There's dudes of bees, but he's actually kind of slow, like that other guy that the CPU drafted, Johnson, he might be the future. Hack, it's now an 86 with 97 speeds so he's obviously amazing. We're nine and eight, but our Super Bowl chances are alive. Let's see if we get through the Falcons and if we do, I can take on this next round. But I like to see 35 to 27 dub over the Falcons. We're taking on the Minnesota Vikings. Dude, we're in 96 overall. Oh my goodness. All right, let's play ball. Let's play a few moments in this game and then we'll sim to see what our squad can do. We still got the white linebacker duo. Quarterback's gonna take off and get rocked by Devin White. I love that. I'm gonna go on Luke McLean here. Second and seven. He's got an underneath to the halfback that I've got covered. He's gonna check down. What? Dante Nix was in coverage for some reason. Can't be having that. Let's blitz. Let's get home. I'm on Winfield. First in goal, we know it's a run. There's the handoff. Oh, it's play action. He chucks it to Hawkinson. I thought for sure that was a run. They got me there. Well, we get to take over ourselves. I don't even know what play this is. Ooh, look at the route. Is that Hackett? Didn't even tell me who it is. It's gotta be Hackett. That was 97 speed for sure. All right, let's go to Kenneth Walker. We got a 99 overall halfback. We've got a superstar tight end at fullback. We got Tiller. The only person I'm worried about blocking is Hackett. He puts up a great block. I'm so bad. How do I not get in right there? Second time's the charm. Let's go, Walker. Let's go, Walker. No way. I just got sucked out of my dive from some bogetackle animation. Second in goal, same shit, different day. Come on. He just fumbled and the, oh my goodness. All right, that's not right, boys. Let's keep it together. We got the speed demon Hackett in man coverage. Pressure's too quick. Damn. Let's try again. Let's believe. Hey, there's the speed demon. It's Nathaniel Hackett's son, actually. All right, first and 10. Here we go. Right in the middle. You're gonna leave one of the best tight ends in the league, unguarded? All right, here we go. It's a big blitz right there. There's X in the middle. First and 10, boys. We gotta get in the end zone. All right, let's look at Kevin Tiller. Let's look at Kevin Tiller on this play action. Oh yeah. He's got a linebacker in coverage. We love that. Let's go. Kevin Tiller. Such a beast tight end. It's seven to seven. I'm gonna take over for one more drive. Kind of like Hackett over the top of this if this is man coverage. Oh, it sure is. There's Hackett. Great catch. It's so weird saying Hackett. I keep thinking of Nathaniel Hackett. And we could punch it in in the red zone here. We're on the five and they are not ready to stop Kenneth Walker. So we are going to Kenneth Walker. Gosh, you're gonna need a lot more than three down. Dude, I keep getting.  Three down linemen on the one. What's wrong with you? What's wrong with you, Minnesota? All right, 14 to seven. Minnesota ties it up 14 to 14. 21 to 17. Wait, there's not much time left. Who's got the ball? Minnesota's punting and they're up by four. So we have a chance, but not a big one. No timeouts. No, we're not gonna take this home, are we? 17 seconds left in a dream. Our Super Bowl dreams are on the line. Our playoff run on the line. What a ball. Get out of bounds. Oh my God, no way this is possible. What a throw to Josh Downs. 11 seconds. It's actually possible you can't get sacked. This is why we have Tristan Werffs. No way. Tristan Werffs, who are you blocking? Another laser. You gotta go end zone now. Second and 10. Honestly, if that was caught, it would have been a bad ball. Five seconds left. Tristan Werffs, we need you to stop 96 right now. I don't know who that is, but he's scaring me. Yes, great double team. End zone. End zone. Swatted down. And year eight ends in the division. Damn it. Hoyer with 326 touchdown. What's in store for us in year nine, boys? We're having a lot of success. We're winning a lot of games. We're clearly a successful franchise, but we only have one ring to show for it. And I feel like who wants to win a bunch of games but not go to the bowl? What are we, the Dallas Cowboys? Sorry. No luck in free agent seasons. We're a negative 30 mil in available cap space. We've got round one pick 26. I think an eventual replacement for Winfield isn't the worst idea, but we might just need to take the best position available. Tyreek Crosby, outside linebacker. Elite speed, great Excel. I got to take that every single time. Hidden dev 65, 250 at LSU with 86 speed and 88 Excel. Yes. Definitely the right choice. I don't know that he'll be an impact in this year or next year too much. Just because we do have really good linebacker still, but this is a 10 year rebuild. And I still got to think about the future of this team.  This is basically like the best player available theory. Theo Hankins was a dog too. We just drafted two hidden dev linebackers back to back. And I'll let the CPU take over for the rest. That's a really solid first and second round. Draft recap. So Crosby's a 74, Hankins is a 73. That's awesome. CPU got a 71 half back. Probably not the worst idea because Kenneth Walker's getting older. Best in the class is 81 Luke Carrington, wide receiver, then there's Nick Newton and Niles Hayden. So headed into year nine, we do have some serious regressions. We couldn't afford try on Shoyinka. We're already negative 30 million salary cap and he's a superstar X factor outside linebacker. So he's gone. McLean regressed. Somehow this dude's been such a dog. I don't know how he regressed down to superstar, but he did. Nix is a 99, McLean's a 99. Winfield's a 98, Harper's a 95. Jefferson's a 93, but now our backup corner since Jamel Dean, we traded and Carlton Davis retired or maybe it's the other way around, but regardless our third corner is not so great. Good thing we got those linebackers because I had vacancies. Crosby and Hankins now are actually starters. So they will be impactful. Walker, Hoyer, Taylor are amazing. I have three superstar tight ends. You know, if we really needed to, we could do something about that, but I'm not sure what I'd really want to mess with on this team right now. We're in a good position. I feel kind of scummy like scheming the CPU for trades though. So I just want to see how this year nine is going to go with this team that we truly built right here. The fact that we have Hoyer at a 98 and Walker at a 98 and that amazing tight end, I feel like that should be enough. Year nine's an improvement. We did have an easier regular season schedule, but we'll be taking on. This is so crazy because this playoff game in real life hasn't happened yet. We're taking on the Lions who are eight and nine and made the playoffs. Taking a look at our stats for the season. Hoyer keeps finishing really well, 4,300, 829 and six. Walker still an absolute dominant force. Downs 1060, Tiller 970 and eight. I feel like our receiving stats earn us good as some of the season we've had. We've had multiple 1,000 yard seasons. And look who finally is the leader, Tanner White. And oh my gosh, Devin White is gone. I forgot about that. We couldn't afford Devin White either. God, this team has changed so much. Dante Nix is really doing everything for us on QB Saks, but you know, we definitely miss having Max Crosby, Vita Vaya and Dante Nix. That was when we won the Super Bowl. Pretty hard to replicate it with the talent we have right now. I think, I don't know, I think I'm basically like overpaying at positions that I don't need to be paying for. Like I'm spending 35 mil right now on Tristan Worfs on his last legs. So yeah, it's just tough. One Super Bowl in 10 years with this good of a team is actually proving pretty damn difficult. I'll advance through this week since this should be a win and then we can check in at the divisional. Our game against the Lions is a W 27 to 24 and we're taking on the Washington commanders. I'll play a few moments here and we'll simp through to see how the squad does in year nine. I think after this year though, if we don't win anything, I do need to make a serious change because like I'm actually Dallas Cowboying this. I've made the playoffs like what, six out of the nine years and we have won the Super Bowl from that. I just feel like we're going to the playoffs way too often and not doing enough with it. All right, let's start out with the drive here. I see my boy hack it. The speed demon opened down the seam. There's 20 yards to start it out with Hoyer. I'm going to look at my boy Kevin Taylor next, see if he finds his way open on this. He doesn't, but we have, we had the escape route. All right, second and 18 is this man coverage. It is, oh my God, these Blitzes. Look at the Blitzes Washington sending. These are nasty. Oh, I got my boy. No, no, no. Damn, getting mugged all the way down the field. I'm going to have to punch this away. Really good defense from the commander, dude, I got screamed on twice. Ooh, look at this. That might be a pick six. Damn, 34 is the speed demon. Good juke. Oh, almost Terrell Harper who earlier this year, we traded Dion White for 84. Terrell Harper who's now a 95. It just had a massive interception in this divisional. Dude, we went wildcard, then we went divisional. Are we now going to go to the NFC championship and lose? That would be so sad. I'm not, I don't want that to happen. Obviously I'm going to be happy in the NFC chip, but it would be sad. It would be sad. So yeah, Josh Downs in the seam here. I feel like that looks kind of open. Maybe not, but there's Kevin Tiller. Ooh. All right, we got to go to coach's suggested plays here. Coach wants mesh spot. Third and goal, what do we got? There's Kevin Tiller. Can you get in the end zone? Fourth and goal from the two. I'm not a field goal type of guy. We got a 98 overall half back in a great old line. You got to use it. It's Kenneth Walker's in. Let's go. The Buccaneers are on the board at home. And now I got to let this squad take over. That's enough impact for me. Seven to zero, 14 to zero, 14-7. Might be 14-14 after this. It's 14 to 14. It's 21 to 14 with a minute 30 left. We have three timeouts. Oh my goodness. Third and 10, Eric Hoyer. This is a big one, Hoyer. You can't get flushed out like this. You got to give him a chance, Hoyer. He's only completed eight passes today. But honestly, this is the biggest one. You just got to complete this one. Fourth and 10, a minute seven. Hoyer drops back. You got to throw it, buddy. He throws. I think the commanders are going to win this game. Oh my God. I thought the game was over. I didn't realize we had our timeouts. We stopped Washington and scored. We're in overtime. Kenneth Walker. Oh my God. Our dreams are alive. Second and four. Unloads caught. Nice. Third and seven. Oh my God. Oh my God.  Dude, this guy has such a bad habit of scrambling out of that pocket. Ball game in OT. What an overtime game, though. Hey, respect to the Buccaneers for even pushing it there, but ball don't lie. Well, we're finally positive in cap space after year nine. We've got 300K. But I'm not going to take advantage of this NFL draft. We need to make a trade. The problem is I don't have cap room to do it. I got to trade away. Somebody was eating up a lot of cap here, which is also sad, but it's got to be done. I think it's Josh Downs who's going to have to get moved. 20 million cap for Josh Downs, who's now 31 years old. Jermaine Wagner's 23 car la, oh no, let's trade Carl Aftis because we're going to pick up somebody who replaces him, right? Somebody who does exactly what he does, but better. Look at Will Phelps, 98 overall on the Denver Broncos. So to convince them to give us Will Phelps, we're going to have to offer some serious draft picks. We're giving them a significantly worse edge rusher, but they'll get a first and second round pick. Will they bite? Dude, how do I, whatever. I don't want to talk about it. This seems like a fair trade to me. I'm giving you an old edge rusher and a first and a second for your dominant 26 year old 98 overall superstar X factor. I don't care if technically I could have gotten more out of it. I feel like Madden just doesn't know what a fair trade looks like. So regardless, that's exactly what I was going for. Let's reorder this depth chart and take a look at the lineup. Dude, I do want to look at Will Phelps too. That seems like a beast. So Alani Johnson, you know what we can do with Alani Johnson? Rather than trading Alani Johnson, let's move him to wide receiver. He's going to be like semi slow as a wide receiver, but we need help at wide receiver. And honestly, he can do it. Dude's got 88 speed and 80 Excel. He's six four. He was a small tight end to begin with. Yeah, this guy was born to be a wide receiver. Absolutely. You're not NFL tight end. So now Tiller can still be our tight end. We've got Cobb in here at a 71 overall offensive line. Obviously looking a little depleted since Trish and Worf's did just retire, but it's still pretty solid. Hazes a 77, petite freer is still around. Yeah, we're good. Hankins is now star. White's in there with Dodson. Could definitely use an MLB too. That's a little bit better, but Phelps is now in. Okay, this could have been exactly what we needed. It will Phelps, 99 finesse moves, 87 speed, 91 Excel. This is the exact guy we're looking for. Let's give him some insane abilities. Gotta make him as good as we can. We'll go edge threat. We'll go no outsiders. We'll go inside stuff. And I think we want to go swim club. His X factor ability can be unstoppable force. Will Phelps, ladies and gentlemen, give an Eric Hoyer pocket, dead eye protected and hot route master. Hopefully that'll improve him. All right, boys, our 10th and final season were a 92 overall. Do we have any remaining true tip of Bay Buccaneers? Oh, that's kind of sad, isn't it? There's nobody left. Well, it's a brand new Buccaneers roster. Nonetheless, let's see how this 10th and final season goes. Hoping we can make the playoffs. We've made the playoffs so many times. We obviously didn't have any valuable draft picks, but here's the recap. We got a 70 overall corner, couple 67s and a 68. Nothing impressive.  That is awesome to see. When you train away your first and second round pick and then watch as that draft was trash, it's a good feeling. So Will Phelps was definitely worth it. All right, boys, let's see what we can do. One final season, one final playoff push, boys. We're 10 and seven taken on the 11 and six New Orleans Saints. All right, let's take a look at our final 10th year lineup. I definitely want to get in a few reps with these guys. Hoyer, Walker, Downs, Johnson, Hackett, Taylor, Solid O-Line, Will Phelps now a 99, Nick's 99, so we have two 99 edge rushers, which I think is sick. This is such a weird time to switch to a 4-3, but we should be at a 4-3. This is super weird, we're gonna try this. Yeah, this takes advantage of the players that we have so much better. Damn, I wish I'd seen that sooner. All right, let's take on the Saints. 10th year, boys. All right, second and five. Saints are in scoring range. They're gonna, oh, I almost could have intercepted that, but good tackles. All right, we're pinching Tanner White.  And there's Dante Nicks, I think. Oh no, Phelps. It's the backup D-tackle. Came in for a big one right there. We got Nicks on what edge? We got Will, wait, no, wait, no. That was Phelps. Oh, I had it, right? It doesn't matter what I had guys because they just scored on me. Seven to zero. Hoyer's gonna take over. Let's see what we got, baby. I'm gonna throw Kenneth Walker here. He turns the corner. Huge juke. All right, this will be my last input on this team. Wow, we've been through a lot on this squad. I'm gonna put Kevin Tiller on a corner out. I'm gonna put Hackett inside on a slant. Tiller, guarded by a much smaller DB. He didn't have a chance. Kevin Tiller, nice touchdown. Singing it to the end of the game. We got 14 here. It's all tied up at 14. Saints make it 21. Now 28 to 21, it's possible. No, did we just punt? Oh my God, no. Saints have the ball. Why are they even doing anything with it? Dude, I thought for sure we'd get at least two rings. We, dude, Lonnie Morrison, half back. 14 rushes, 132 yards and three touchdowns.  Dude, oh my God, I wouldn't wanna be a Tampa Bay fan. We go to the playoffs. We get our hopes up every single season. And we came up short. I guess we did get our ring. We got our ring in year six, but wow, that was a tough one, boys. 28 to 21, it was a great game and it was a rivalry game. But that's it for this fucking-ear squad. 18 for 33, two touchdowns, two interceptions. Just couldn't keep it together there.  Chill out. All right, boys, let's get a final season recap. So in the very first season that we played, the Cowboys beat the Ravens in the Super Bowl. In 2024, it was Bills over Rams. In 2025, it was Raiders over Cowboys. In 2026, it was Chiefs over Eagles. A little deja vu and in 20, nope, not yet. Sorry, in 2027, it was Ravens Niners. In 2028, the Ravens went back to back, but lost to the Tampa Bay Buccaneers.  And the year after that, when he left, was a really sad year. We also got offensive player that year, Kenneth Walker. We got defensive rookie of the year, Tanner White. And take a look at the offensive rookie of the year. Lonnie Morrison, anybody remember that name? Because in 2032, when we got smacked in the playoffs, it was Lonnie Morrison, the Saints running back, who had 132 yards and three touchdowns. He was the 85 overall, wasn't he? He was, he was the 85 overall from that insane draft class. 29, it was the Eagles, 2030, it was the Vikings. 2031, it was the Chiefs once again. And in 32, it was the Vikings. There's a very serious Vikings dynasty building. So in 10 years, we probably won 10 to 12 playoff games. We went to the playoffs seven out of 10 years, but we only came home with one Super Bowl ring. So I'm a little bit sad, but it was a tough rebuild. I had a lot of fun and we had a lot of success. Hons of wins, amazing records, but only one ring to show for it. Either way, boys, the 10 year Buccaneers rebuild was an absolute blast. I hope you guys loved it. And I will see you guys in the next video. Peace out, y'all.


Good morning everybody. Hope everybody's doing great this morning. I hope you feel fit in the environment that you're in today I loved it. I love the terminology that she had in that last talk. I think it was great and Just so you understand my background. I'm a drug design chemist by training. I was actually designing oncology drugs in a PhD program at Arizona State and From that I had to do a lot of genetic work and so we're gonna we're gonna be looking at a lot of gene sequencing today and In the context of gene sequences, we're gonna be looking at phylogenetic trees of the endocannabinoid system So I want to kind of get an idea of the background. It's pretty much everybody in here a medical professional MDs NDS. No Do we have any evolutionary biologists in here today? No, thank God because oh So I have to give the you're not gonna believe anything I say I Have to give the disclaimer my perspective on evolutionary biology is when I was doing drug design, we were working on a Enzyme that had not been Crystallized and so we had no structure to work with and so we use gene sequences to look for what are known as conserved regions in the gene sequence because the conserved region of the gene sequence often is a sequence that is important for the active site of an enzyme and That was what our focus was in drug design was enzyme active sites and so I'm not an evolutionary Biologist, so don't expect this to be a good evolutionary biology talk. This is a biochemistry talk from a a Conservation of gene sequences perspective So it's important to understand the the function of endocannabinoids because these molecules over time have evolved in different species and Not all species can produce all of these endocannabinoids for example. We put we produce Arachid on a ethanol amide from arachidonic acid Well, there are some species of insects that don't produce arachidonic acid So they can't produce like Drosophila cannot produce arachidon ethanol amide, but Drosophila can produce To arachidon and glycerol and they don't have cannabinoid receptors So we really don't know why the Drosophila is producing an endocannabinoid when it doesn't have an endocannabinoid receptor and we're going to be looking at some of the Receptors that are non endocannabinoid receptors that bind to endocannabinoids as a result of that so when I look at these I see these as derivatives of arachidonic acid and You probably know that arachidonic acid is an important essential fatty acid I mean we don't necessarily produce enough of it We can produce some arachidonic acid from omega-6's, but one of the problems that I have right now with our understanding of the endocannabinoid system is that most literature research in Endocannabinoid system is focusing on just these two endocannabinoids Hmm, and if they're both derived from arachidonic acid does anybody see the problem with that? Well, yeah Because we get a lot more other essential fatty acids in our diet other than arachidonic acid, right? and it turns out that these these arachidonic acid derivatives are strong cannabinoid receptor agonists and They bind differently to CB1 and CB2 and they have different functions in the human body You'll hear neurobiologists talk about arachidonateethanolamide, which is also known as anandamide they refer to this as a partial agonist and They they talk about it as being tonic in nature. So two arachidonic glycerol is referred to as phasic because What these molecules do is they modulate neurotransmission and so This one is referred to as tonic because it's kind of always there And it's always kind of tuning in neurotransmission and this one Kind of comes in when there are bursts of neurotransmission and it's really important and this is one of the most complex You know the human endocannabinoid systems one of the most complex that is that has been characterized so far so When we look at some of these other molecules This is a derivative DHA and so now we transition from Looking at just omega-3 or omega-6 is now we're looking at some of the essential fatty acids that are derived from omega-3 fatty acids And it turns out that the DHA derivative of ethanolamine is referred to as synaptomide Because when it was originally discovered it was discovered by neurochemists that were looking for things that stimulated synaptogenesis So who wants to go out and get some DHA supplements now? Good lord if I could make myself smarter By changing my omega-3 to omega-6 ratio Sounds promising to me And you'll hear me refer when I talk about the endocannabinoid system you'll hear me refer to what's known as endocannabinoid tone You know and our endocannabinoid tone is largely built upon our intake of essential fatty acids and our ability to convert those fatty acids well convert those fatty acids into These molecules that we refer to as endocannabinoid And so if we are efficient at producing endocannabinoids from our essential fatty acids We would have a positive endocannabinoid tone and if we're inefficient we would say that we have a negative endocannabinoid tone and It's important because the balance of omega-3s and omega-6s is so Important in this one of my favorite researchers Oliver Manzoni has done some groundbreaking work with mice And one of the things that he's shown with mice is that mice that are fed a diet that's deficient in omega-6s or pardon me Wow, there's a slip diet deficient omega-3s There is no diet deficient omega-6s is there no doesn't exist But there it's easy to have a diet that's deficient omega-3s That's a standard American diet because of all of our consumption of the industrial seed oils I won't call them food oils because they're not they're industrial seed oils and they're good for one thing lubrication But what Oliver Manzoni has shown is that mice lose Neuroplasticity in the absence of omega-3s who in here would like to have less neuroplasticity Sign me up Maybe I could become president so We know that in mice they lose neuroplasticity if they don't get omega-3s and we know That the DHA ethanol amide endocannabinoid was discovered by people that are looking for things that stimulate synaptogenesis Paints a compelling picture for me. Does it not for you to quit drinking or eating omega-6s? so The last molecule that's up here is another one that is a serotonin derivative of Arachidonic acid that has endocannabinoid function There's also a dopamine endocannabinoid and so the point is I want you to understand that your diet influences your endocannabinoid system Dramatically, and we're just scratching the surface on these molecules And we need a lot more research that doesn't just focus on The first two that were discovered and actually if if I put this slide presentation into historical order We're going backwards Because the endocannabinoids were actually discovered after the receptors were discovered and the receptors were scubbed were discovered after THC was characterized and so Our whole understanding of the endocannabinoid system is backwards because we discovered we meaning Raphael McCoolam discovered THC in the 60s, and then we thought THC just had some magical property with neural membranes until 1990 when the first cannabinoid receptor was discovered the second cannabinoid receptor was discovered in 1993 and then the endocannabinoids were discovered in the late 90s and so our understanding of this is built backwards and we have a lot of laws associated with cannabis that put a lot of roadblocks in front of the Researchers that were doing this kind of work Okay, so when we look at the the gross Physiology of cannabinoid receptors You'll often hear people saying that CB2 receptors are found in the immune system. Well, they are that's true And they're found in a lot of other places in the body, and they have a lot of diverse functions one of the primary functions of CB2 is in the blood-brain barrier and in the gut barrier CB2 is absolutely essential For normal permeability it maintains normal blood-brain barrier permeability by controlling cytochrome or cytochrome cytochine inflammation and so CB2 you'll often hear that it was that it is in the immune cells But it was it was discovered in the rat spleen, which is why people think it's only in the immune cells It is it is found in a large number of other cells besides immune cells and has some pretty diverse function CB1 I focus primarily on The synaptic function of CB1 because I think that that's probably the most important function of CB1, but CB1 also has influences on some of our very Fundamental physiological homeostatic processes like eating Everybody knows that you know cannabis is is really important in the oncology population And I want to be one of the few people that are out here saying cannabis does not cure cancer It's not a magic bullet It's a really important toolbox in the in the toolbox of the oncologist because Western medicine has nothing for The anti-medic effect that cannabis has Western medicine has nothing to improve appetite in patients with catechia And so like every other thing in the toolbox of the oncologist Cannabis has one thing that needs to be applied with all of the other tools So when you hear people say that cannabis cures cancer turn and walk Please that's not good science. That's bro science and I work in the cannabis industry But I am unpopular in the cannabis industry because of my stance on good science versus bro science so Some of the other things that are really important within CB1 function our motility in the gut This is why CB CB1 antagonists like like THC are really good for patients with Crohn's and IBS those Spastic conditions of the gut can be quieted down with CB1 receptor agonists Okay, a little bit more Closer look I've been doing a lot of talks about meta metabolism nation. I just spoke at low-carb USA and I Tailored this talk to fit the the overall metabolic function of CB1 and CB2 And it's interesting because when you look at things like CB1 stimulates glucose uptake in adipose tissue This is not a sunny side up egg. That's supposed to be an adipose cell and In adipose cells or sunny side up eggs CB1 increases glucose uptake it increases insulin sensitivity and it increases the storage of fats But one of the weird things about the population studies of cannabis users and Animals is that in in these studies cannabis users are typically lower in BMI Than the general population. Well, does that make sense when you think about? CB1 stimulating the uptake of glucose and the storage of fat. Well, no it doesn't I call this a stoner paradox We'll come back and look at this a little bit later in the talk, but I just want to confuse you up front and Bring it back. I mean it's confusing because we have these conflicting things between cell line tests and animal models And this is often true in biochemistry because you know, we probe these type of activity using pharmacological methods like can't cannabinoid receptor antagonists and we probe with with agonists Pharmacologically and we you know, we look at different cellular functions and often they don't add up in organism level studies So we'll come back and take a look at this because there's more to this when you look at the organism Because of all of the things that are previous speak spoke or Speaker spoke about in terms of how different cells within the organism have to cooperate And so whenever you look at cell line or enzyme level Data you always have to recognize it There's a limitation and when we put that data into the context of an organism level study it will likely not necessarily fit Okay, so this is where the rubber beats the road in terms of CB1 function This is what I think is the most important part of CB1 function the synaptic model. So in this model on the left We have a an excitatory Neuron and on the right we have an inhibitory neuron and they come together and they they Intervate with a post-synaptic neuron to do their thing and their thing is neurotransmission What we what we see with endocannabinoids is the endocannabinoids are produced post-synaptically By specific enzymes and we'll talk we won't talk too much about these enzymes in terms of the Genetic evolution, but just know that there are Enzymes that produce these endocannabinoids and not all organisms produce these enzymes And so what we see here is the most complex endocannabinoid system that exists in nature as we know it today And so these endocannabinoids are produced post-synaptically. They're transported. They go to receptors presynaptically and They modulate the release of neurotransmitters They don't stop the release of neurotransmitters. They modulate it. And so like the anti-lock brakes on your car they They tune the release of these neurotransmitters so that your central nervous system does not overload itself with information or or neurotransmission and so there's there are Direct relationships between these receptors and the release of neurotransmitters and and when the The receptor sites have been bound the end of cannabinoid is then broken down into its It's individual synthetic components. And so we have enzymes that do that as well And so there are organisms that have the enzymes that to produce some of these endocannabinoids that don't have cannabinoid receptors and There are organisms that have the enzymes that break down endocannabinoids that don't have You know connect the cannabis the cannabinoid receptors so in general when we look at This it's a really important thing for the overall longevity of the central central Excuse me of the central nervous system and because we have such a complex Good lord. Sorry. We have such a complex central nervous system It's important that our bodies can regulate neurotransmission and especially excitatory neurotransmission because excess glutamate neurotransmission is associated with chronic neurodegenerative diseases like Alzheimer's ALS And so this is where the neuro protective effects of phyto cannabinoids are important Okay, are we ready for For the gene sequences So this is what's known as phylogenetic tree and this is a phylogenetic tree for The CNR1 CNR1 is the name of the gene that encodes for CB1 receptor and so You can see from this that there are some differences in spacing and if you're not an evolutionary biologist What what this tells us is that there is a large number of species that produce the cannabinoid receptor and You know some of these are You know advanced organisms organisms like the primates and some of these are simple organisms and You know some of these organisms the elephant shark is referred to as an evolutionarily resistant Species because it has not evolved in you know hundreds of thousands of years and so when you see Evolution evolutionarily resistant species like the elephant shark that are expressing cannabinoid receptors that have a high degree of homology with the human receptor It means that this receptor has something very fundamental with our basic physiology That's the main thing. I want you to come out of this is That when you see a phylogenetic tree like this that spans from Mammals to invertebrates it means that that gene is really important in terms of the basic Function and it's it's funny because in different organisms You know, I look at a lot of different studies and there are bird studies that have shown when birds are treated with cannabinoid receptor Antagonists it changes their song pattern So by blocking their cannabinoid receptor, it's their song patterns are fundamental to their entire social structure And if you can interrupt that with a cannabinoid receptor antagonist, that's a pretty profound evolutionary Effect right there in mice Cannabinoid receptor antagonists in mice pups inhibits suckling Well, that's a horrible thing to change evolutionarily, you know when we when we look at how Receptors and different genes evolve over time There's a lot of these receptors that are you know genes that evolve faster than others And this is one of the ones that has had evolved very slowly over time and Part of it is because there's a lot of crossover and what I mean by crossover is this so this is the enzyme Monoacylglycerolipase that breaks down to arachnidolglycerol Cox2 is the enzyme that that we are familiar with because of the the class of drugs Nonsteroidal and anti-inflammatories right cox2 inhibitors block the production of inflammatory Prostaglandins and remember that prostaglandins are fatty acid derivatives as well and it turns out that cox2 can metabolize the endocannabinoids as well and this is why When I look at the phylogenic tree, I want to look at things like cox2 I also want to look at some of the other enzymes in The human endocannabinoid system that are bound by the endocannabinoids So the the last one here FAH is the enzyme that breaks down arachnolaptenol amide also known as anandamide and so there's there's some some Authors that believe that by blocking cox2 We actually have a little bit of an antidepressant effect because remember anandamide was derived the name anandamide It was derived from Sanskrit Ananda which is bliss okay, so This is the phylogenetic tree for the cannabinoid receptor 2 and CNR 2 the gene CNR 2 encodes for CB2 receptor and here is where there is a lot of disagreement within evolutionary biology. There's There there was a split at one point where there was one organism in the phylogenetic tree that Produced a mutant CB1 and There are some people that believe that that mutant CB1 is what became CB2 evolutionarily and the reason they believe that is because there is a high degree of Homology and everybody get what I mean when I say homology. There's a lot of you can see The similarity in each of these gene sequences. That's what homology is There's a high degree of homology between CB1 and CB2 Which suggests that there's an evolutionary relation between the two But there's only 44 percent homology which which means that it It probably is within the same species that the split happened and so This is one area where there needs to be a lot more study. I mean I think the first Study that I actually could pull up on the evolutionary biology of the anokinabinoid system was 2000 And then there was really nothing till 2005 and there was 2007 and I think you know You could count on both hands the number of published articles on the evolution of the endocannabinoid system, so This is a representation that I used at a conference on low-dose naltrexone and the reason I wanted to put it up here is because endocannabinoids and phyto cannabinoids are referred to as promiscuous receptor binding because they bind to cannabinoid receptors they bind to Vanilloid receptors they bind to opiate receptors and because of that when we talked about The evolutionary biology we have to think about okay if an organism produces endocannabinoids, but it doesn't have Cannabinoid receptors well, there must be some other function in that organism and likely You know TRPV is a suspect to look at in organisms that don't have cannabinoid receptors And the vanilla receptors are important for the sensation of pain and heat and over their evolution the vanilla receptors have actually split into receptors that can that can sense heat pressure and acidity and This is the evolutionary tree for the TRP receptors and it looks like It's not as diverse as the cannabinoid receptors, but there's a large number of organisms that have these receptors and It's important. There's the elephant shark again It seems like because it's evolutionarily conserved. It's an ancient gene It's probably pretty important for a lot of fundamental processes Um CB2 I wanted to come back. We're not going to look at much more in terms of phylogenetic trees I want to take this back into physiology again and leave you with some of Some of the physiological thing that you as practitioners can be looking at to help your patients that have issues with their endocannabinoid system. So CB2 we talked a little bit earlier about The Neurological importance of CB2 so microglia and astrocytes CB2 has a profound effect on cytokine inflammation As we all know cytokine inflammation is the backbone of most chronic neurodegenerative diseases One last phylogenetic tree FAH this is the enzyme that breaks down the the endocannabinoid Raccoonolethanolamide Just notice that there's a lot of different enzymes that have this but to me when I look at this I see there's less Single cell organisms and there's more mammals on this. So there's something about this enzyme that tends to be more It's found more often in the complex organisms like us Okay when we look at metabolism we talked a little bit earlier about Obesity and BMI This study was looking at mice and what they were saying was that They concluded the inability of omega-3 fatty acids to reduce adipose tissue and serum levels of classic endocannabinoids Might contribute to lack of beneficial effect of these lipids on glucose homeostasis and type 2 diabetes Clients will remember that the classic endocannabinoids are from omega-6s so they kind of missed the boat on this and When we look at CB1 and CB2 receptor function in terms of How they influence? fat mass we see that there are some Influences based on the expression of RNA for insulin and Glucose uptake proteins and so this once again I Don't think that this fully explains The the role of the endocannabinoids system in how our our body Distributes and stores adipose tissue when we look more deeply into this the CB1 receptor actually is down regulating mitochondrial function Well, that doesn't fit into what we would think is positive for overall health But when you look at it It seems like the insulin receptor is Central to the ability of the endocannabinoid system to either have a positive or negative effect on our disposition of adipose tissue and Modiculant and it's directly related to how insulin influences mitochondrial function and there is an interplay between that toll like receptors and the cannabinoid receptors We look at in a cannabinoid system function at adipose tissue and It is actually CB1 receptors actually blocking the carnitine shuttle Well, that doesn't bode well for the ketogenic diet as it would seem right We look at the inter cannabinoid system and brown adipose tissue versus white adipose tissue and we see things like Increase in fatty acid uptake in white adipose tissue, which we would think would probably lead to obesity We look at fasting fasting is influenced and influences the endocannabinoid system and the stoner paradox We we see in mice that Adult male mice that have dietarily induced Obesity and remember when you're inducing dietary Obesity omega-6 is a really really good at that But omega-3s are not We look at the gut gut function There's a strong interplay between cannabinoid receptors and the immune system in terms of how gut permeability is controlled and it turns out that gut permeability has an interplay with With the microbiome and so The endocannabinoid system influences the microbiome and the microbiome influences the endocannabinoid system There's a lot of great mouse studies on how there are specific Gut microbiota that are influenced by phyto cannabinoids and there seems to be a protective effect when we look at the phyto cannabinoids Delta 9 THC And this is for clinicians. I think this is a really important thing to look at. There's a genetic reason why Oral consumption has a 7 to 72 hour range of half-life for the physiological effects of THC Horrible horrible Pharmacological profile and that's oral inhaled really predictable three to four hour half-life and Really predictable response. There's a genetic variation in Cytochrome 2C9 which is the cause of this because oral to consume THC goes through first-class metabolism and if you have Polymorphisms in your 2C9 you are likely going to be either an ultrafast or ultra slow metabolizer of Delta 9 THC CBD which is how to cure everything Is really important. I think that it should be treated like an essential nutrient, but I wouldn't say that it's going to cure your cancer Has an incredibly long half-life. So when you're thinking about dosing these things are really important I love beta-carry-off-lane and the reason I have this in here is because beta-carry-off-lane is a CB2 selective agent And it's also found in Some of my favorite foods. So clove Black pepper shiso anybody know shiso from your Japanese restaurant if you don't next time you get sushi order shiso With one of your sushi rolls. It's one of the most brilliant herbs that exists on the planet Mercy mercy and lining I put these two here to contrast them because most modern quinovars of cannabis have been bred to either produce mercy and are called Indicas or they produce high levels of limonene or piney and they're called sativa's well the indica and sativa are How many f-bombs can I drop when I think about How much of a gross generalization they are the thing is Strain names don't mean anything you need to think about these is quinovars because Mercy has Profound pharmacological activity. We're gonna everybody mind if we go a little bit over into the Q&A We got a couple more slides. We don't have a lot, but I think that this is really important So mercy's activity can actually be blocked by the drug naltrexone Which implies that mercy is an opiate receptor Agnest and so when you think about Pharmacological utility high mercy and strains which have been bastardly called Indicas can be really good for pain management and especially if you're doing an oral preparation that has an extremely long half-life This can be something that has very profound positive effects for cancer patients that have metastatic pain Because that pain is not touched by many things and as you know Opiates are probably not the thing that you want to manage that pain on the the ups the positive side I refer to mercy high mercy and strains as being kind of Heavy and dark They're really good for sleep, and they're really good for pain But you don't necessarily want to go drive a front-end loader when you're consuming a high mercy and strength Especially if you're consuming it orally And I refer to limonene is being more light everybody Everybody knows the smell of citrus and everybody knows that it makes you feel good, right? I mean, this is why citrus is in cleaning products because limonene has a positive uplifting feeling and high limonene strains tend to give you a kind of mindful and you know uplifting high and You'll often hear them refer to a sativa which doesn't really mean anything, but There was a study in Japan in an institution, so it was pretty well controlled They showed that just by smelling limonene essential oil in a cotton ball in a mental institution They reduced the consumption of pharmacological antidepressants. That's pretty powerful. I think so To tie this back into evolution and how we co-evolve with our foods I really would have loved to have been able to do a co-evolution of how phyto cannabinoids produced by plants Influenced our evolution, but there's really no data on it yet, and I would be sitting up here making stuff up But what we do know is that part of our Agriculturalist evolution we've included a lot of things like spices And this is one of the things that I want to caution you about when you're reading mouse studies How many mice are consuming beta karyothelene rich herbs when they're eating a high-fat diet? Well, probably not unless there's their Ayurvedic mice, right? You may know any Ayurvedic mice. I bet they smell good But it's important when you look at these studies that are looking at high-fat diet Number one recognize is that high-fat diet just omega-6 is well for mice. It likely is or is it just saturated fat? Well, probably and there are some issues with that. I mean, I don't want to know what a high-fat diet does I mean we already see that in the general American population, right? It's not a good outcome When we look at high omega-6 fats But the thing that's often overlooked is how do these phytochemicals from our culinary herbs Influence our metabolism and our microbiome and I think that that's the take-home message is we've evolved to develop receptors and enzymes For endocannabinoid system that that influences our basic things like hunger, you know extinction of fear these things are primal In terms of our neurological development and it's important that we can include These kind of things in our diet to modify our endocannabinoid system so that we can have a healthy endocannabinoid system Okay with that we have any questions It was interesting. You mentioned the Neltruxone LDN low-dose Neltruxone five milligrams a day is as maybe in my Antiquated history I've been touted as a anti-aging cure all no downsides But you just mentioned it a block something perhaps useful But is there a daily a normal daily function our body? Do you have any comments on now? LDN in a good or positive or negative way so low-dose Neltruxone one of the positive effects of low-dose Neltruxone that's not observed in high-dose is Upregulation of the opiate receptors and you know There's other there's other things that low-dose Neltruxone does it is it antagonist of toll-like receptors So there's an immune component. That's really important The probably the most important thing that low-dose Neltruxone does is it also is blocking the Opiate receptor the opiate growth factor receptor, and I think that that's probably one of the more important things I don't think that you know when I when I mentioned that that the effects of Mercy were blocked by Neltruxone. That's high dose typically a pharmacological dose of Neltruxone that will block Opiate receptor agonist is high dose Do you have any Do and or don't Thoughts on LDN as a long-term and the aging protocol? My understanding is not from the clinical side So I can't really comment on that nature would be a better person that she has like the clinical experience with low-dose Neltruxone Thank you very much for your talk super interesting Obviously CBD is everywhere and there's tons of hype around it That could be a whole talk, but would in your opinion What do you think that there are benefits for CBD and what would be kind of the top ones in your opinion neuro protective effects? I mean the the US Department of Health and Human Services Has a patent on the neuro protective effects of CBD and they name the NMDA receptor system and the ampere receptor system as the primary targets and remember the NMDA receptor system is Link to almost every chronic neuro degenerative disease and so I would say Number one. I'm not gonna say that CBD cures anything But it's the if I were to take any, you know phyto compound on a daily basis It would be CBD and simply because it's just really it's a really good tonic for so many different things Yeah, well, thank you Steve. It's gonna be a big round of applause for that great talk


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