Hey guys, it's Monica. I am going to share with you a couple of things that I have received, some things that I have bought and absolutely love, and maybe, you know, there's still some time between now and Christmas. If you are at all like me, I'm a last-minute holiday shopper, I am that typical person that a couple of days before the holidays, I'm running to the store, I'm trying to do this, I'm trying to do that. So I'm very much last-minute when it comes to the holidays. But there's a couple of things that I got that I really, really liked and I want to share them with you in this video. And also at the tail end of the video, I'll give you an update on my dad because I know many of you have asked. So stay tuned if you're interested in some of the cool things that I got. Okay guys, so first of all, I guess what I should tell you is, and I always, I'm not really good at this because I always kind of forget to tell you what's on my face and many of you ask afterwards. So on my skin right now for a foundation, aside from obviously my skincare, is my YSL All Hours Foundation. This is a foundation that was actually sent to me quite a while ago, originally from the Octoly Network. I really love it. I think it's a beautiful, beautiful foundation. I use this more on special occasions. It's also a perfect foundation for filming because I think it makes your skin looks really nice. So this is the foundation I have on today. Most of the time when I'm filming, I have my Estee Lauder Foundation on or my CYO that I'm trying to finish. I'm going to try to get really good on mentioning what I have on at the beginning of the video, unless it's a vlog style video where you have many different video clips. So I have this on my face and then so I am trying to get better and trying to do a little bit more contouring, but I kind of really mess up on that a lot. But on my face today, I am using the Visiart Palette. This has a highlighter, it has a blush, and it has a contour and I'm actually using all three of these on my face. The contour, I went with my contour brush right here, a little bit on my nose, a little bit on my high forehead, and then I just dabbed the blush on. And then kind of with my It Cosmetics, I have one of those really nice It Cosmetics brushes for your face, I kind of blended it or tried to blend it all in. And then at the very end, I just dabbed this highlighter just a little bit here, a little bit here, and hopefully I didn't do too much of the highlighter. But that's really all that I have on my skin. But on my lips, I have my NYX. This is the lip liner, between this and the Avon lip liner is what I use the most. And this is what I actually have lined my lips with. I line her girl by. I kind of, I really like this because it's sort of a neutral shade for me. It's not too bright, not too pink, more of a mauve-ier look or a wine look type of thing. So I line my lips, I go a little bit over my lips because I have thin lips. And then what I put on today, and this is, I love these lippies. I have to tell you I love these lippies. This is independent. I'm going to try to show you and I'm hoping that that picks up. So this is the shade independent. And that's what I have on my lips. This lipstick, let me tell you, I have discovered color of the world.  I bought this, I want to say, maybe three weeks ago. And I've been using, since it arrived, I've been using the lipsticks almost every day. I got the package that has the, it's got the, it's got three different colors. And it also has a lip treatment and moisturizer. This is really, really, really nice. I really like this. But let me show you the shades that I got. So I have independent on. And when I got, I have independent on, which is this one. And then when I got independent, when I got these, I thought, oh my gosh, these are all, some of these are going to be so dark. I'm not going to be able to do it. But the one that I've actually worn the most is called empowered, although I think independent is the prettiest shade. Empowered when I looked at this, I said, I would never be able to pull that off. This one closest right here to my fingers is empowered. I thought I would never be able to pull that off because it looked so dark and I'm like going, oh my gosh. So yeah, it is dark. It is empowered. I do like it. I've actually worn it the most. And the one that I've worn the least is flawless. And flawless is really pretty. I'm going to put that one. And it's actually the most pink, at least in on my skin. It's the third one here. Flawless. I love these lipsticks. I love these lipsticks. So I have the three lipsticks. And then I have the conditioner, the moisturizer. Oh my gosh. Are they lovely? Anyways, color the world. Let me just tell you a little bit about color. These are hand poured natural lipsticks. And the ingredients are all excellent ingredients. You have to check them out on their website because the stuff is just really beautiful. It's all natural. It's vegan. It's cruelty free indie company. And it's I believe in North Carolina. Let me see if I have the address here. I don't. North Carolina or South Carolina. I don't know which is one of the Carolinas. I always get them confused. Anyways, I saw these ads all over Facebook and they are supposed to not bleed into your lip lines. And I thought, wow, isn't that like amazing if that would be true? Well, I will tell you that is true, at least on my lips. I love these so much that when and, you know, they have a couple of different sets. I'll list the set that I got, but I would repurchase these hands down because even the darkest shade that I thought was going to be not good has been fabulous on me and none of them have bled.  No, not at all. They're not going to be like lasting.  So these have been creamy, beautiful color, long lasting. Now again, long lasting to me can be two hours, right? I've had my coffee. I've had a few other things and I don't have to touch up. But if I had to touch up, I wouldn't care. I love these products. These are so super awesome. It's also, I think, a biodegradable cardboard. So they're very, very conscious of the environment. Hand poured, beautiful, creamy lipsticks. I'm telling you, they're worth every penny I paid for them. This is not sponsored. They did not send this to me. They don't know me from Adam, but I just love these lippies. So I'm thinking if you want to get somebody a package of really nice lipsticks, think about doing that because I just think it was an amazing set. The other thing I want to tell you, and I think this is absolutely a great idea for the holidays too, if you like something extra special, like something made in France or something just not quite your run of the mill every day, then Mademoiselle Province, which is a product, these products are made in France, just might be what you're looking for. Now, full disclosure, this was sent to me via the Octoly Network. So when I went on the Octoly Network and I saw this gift pack and I read the ingredients and I said, oh, I really like this. Again, independent, a woman owned company. It's owned by two women. I just thought this was really fabulous. So they put together this gift set and they have a lot more other products. You can check them out on their website. They are again cruelty free. They're made, they're vegan, they're vegan friendly, I should say. All their products are made in France with natural formulas. Really pretty presentation when I got it. So this again was sent to me via the Octoly Network from the company. And what I got in there was, I thought this was the cutest little thing, got this really pretty. Oh, this is going to catch it. I might have to include a picture, but really pretty. You can hardly see it. There's a beautiful woman sitting mademoiselle province made in France. It's a makeup bag or a bag that you might want to put your hand care skincare. Anyways, they have the most amazing and most of the ingredients and everything is listed in French. So I can't read it for you, but they, this is a body cream and this is really, I don't want to put it on because I got all the samples of my, I have to wash that off. But this is a really nice, nice body cream. I really like this. I put this all over my arms. It's beautiful. And then they have a really, really gorgeous. This is at high intensity hand cream. And again, this is cruelty free or and vegan. You can check it out. It's mademoiselleprovince.com. So in the gift set in this little box, which I think is perfect for the holidays and they always have sales going on. So I'm going to list all this information for you below in the, in the box, but this was sent to me complimentary from the company via the Octolier network. And I just think it's a great, lovely Christmas or holiday gift set that you could give someone if someone wants a little bit of luxury or you want something that was made in France. And this cream is really nice. I really, I like it. I like it a real lot. Wanted to mention that because I know the holidays are coming. I got as a friend's gift, the most amazing thing from one of my friends. It wasn't really technically a Christmas gift, but I'm showing it because I think you can still get this. If you are looking to buy a gift for somebody for the holidays, this is a really cute gift set. This is actually sent to me from Sheila, life with life. Oh my God. Simply Sheila, formerly life with Lily. And this is the Two-Face Christmas Cookie House party. It came with a bunch of different things. I'll show you everything on the back. And it, it's just, it was just a really pretty, it's not a Christmas gift. We're all laughing at each other. It's not, not Christmas gifts. But anyways, it came with this really pretty palette. I haven't used it yet, but I, I really like these colors. I think these colors are really pretty. They look right up my alley. I like the fact that there's some glitters and, or I should say, shimmers. And the mattes look really nice. And to me, a lot of these, these shades that would work for me. So I really like this. And then also along with it came this, this is the season to a sparkle. So this is really cool because if you want to add a little bit of sparkle to your eyes, it also came with this really nice little, it's like a highlight, frosted, frosted contour. I haven't, I haven't dug into that yet either. But it actually comes. It's a really cool gift set. So you can still get this at Sephora, I believe. Great opportunity. I got it as a friend's gift, not as a Christmas gift, but I love it. So one other thing I wanted to say to you guys, I don't know how late it is getting on this video. I recently went to the Cosmetic Company store and I had really, until I got this friend's gift from Sheila, I really had not paid much attention to Too Faced. I'd never really tried anything Too Faced. But when I went to the Cosmetic Company store, I saw this Too Faced palette. And this is an anniversary palette. And I, oh my gosh, and it says celebrating 20 years of being fabulous. How cool is that? So this probably came out in last, you know, sometime last year, obviously. So I don't know if you can still get it. I think you can. But anyways, they had a pile of this in the Cosmetic Company store where I go to. And what it did, and I want to make sure I kind of cover the mirror so I don't blind you, it has the top row are colors that they had out in 1998. And the bottom row are the colors in 2018. Anyways, I have been, I have this all over my eyes right now. I hope you can see. But I have been playing with this palette. I really think, I think this is amazing.  So I start out with a couple of different layers. But this palette is amazing. And I think if you can get this, if you have a Cosmetic Company store near you, you can check Too Faced. I just don't know if you can still get it. But if you can get this out of Cosmetic Company store near you, I thought this would be a fabulous, a fabulous gift. And the presentation is so pretty. The case is so pretty with the pink sparkly, the gold writing. You know, if you can get super excited about a presentation, this really did excite me. Anyways, I got, I got like so, I got such a kick out of the blue shimmer up at the top. I thought this was the most prettiest thing. Of course, today I used the pinks and the purples. I used this, this, this. And then I used a little bit of the white. I used everything from 2000, from 1998 on the top. I did use the one color, I think it's GG of 2018 on my movable lid. And then I lightened it up. And then in my outer V, I went into with the darker color from one of my other palettes in my outer V. But I thought that was like amazing. I really loved it. So what a cool, I thought this was super cool. And I would never have found this if it wasn't that I got the friendship gift from Sheila with the two face palettes. And she sent me a bunch of other things in there as well. Masks and all sorts of stuff like that. I thought holy mackerel is so cool. So thank you, Sheila, for sending me this non Christmas gift. That made me find that palette. And I think when I do my favorites, my highlights and lowlights of 2019, you know, we'll see what ends up making it. But I really like that. And other thing I got, and I have, I had no idea this was coming. And I'd never heard of Emma Hardy. And this is their EH, is their logo. And this was their anniversary bag. And I'm going to show you, I'm going to super impose a picture of what I got in here. I didn't even know I was getting this. This was quite a surprise to me in the products. I looked them up on their website. Their products sound awesome. So I haven't started to use them yet, but I absolutely will. And I will definitely report back. And I'll definitely let you guys know how much I like them. But I'm excited about this. Thank you so much for it to Emma Hardy.com for sending me this PR package. I'm like thrilled. So the other two things I wanted to mention to you really quick is I was sent these eye masks from Active Layer. And I know that most recently, a very detailed video was done by Kristen321, Ms. Kristen321. I'll make sure I link that video down below. She did an amazing video on this. And she had been using this Active Layer. She'd been trying it out. She showed on camera the demo of the eye patches. And the other two people that I know that have been using this, one is Marlene Fab and Glam. And the other one is Natalie the Beauty Deaver. Both ladies have been using this product and both ladies really like it. So I had the opportunity to give this a try as well. And I really like it a lot. So what you do is it comes with this little spritz of water. And the water is a little tiny bottle like this. And just spray. You need to make sure that you have that your skin is clean before you put the eye patch on. Each package contains two eye patches. You peel off the plastic covering and you make it so the blue part stays on the outside. You put it on super, super wet. You press it in then and you make sure that the white side is what you're pressing into your skin and the blue is on the outside. And you can see when it gets really dark, you can see that it's getting wet and that's what it needs. And then I did the other side. I did mine much like Kristin did hers. I did one, put it on, sprayed the other, tapped it in, put it on. You're only supposed to keep it on like five or ten seconds or something of that nature. Then I went and I just gently, I didn't want to, I wanted to make sure it was well moisturized because I didn't want to do any tugging or peeling and that's what I was really worried about. So I would tug and peel that it would pull my skin. It didn't do that. I was just able to gently lift it off and everything the product had completely sunk into the deeper layers went way down and my skin felt good. I took the other one off. Same thing. I could feel a tightening feeling when I first started to apply it. After I was done that, I followed up with my regular eye treatment. So in other words, my eye creams, whatever eye cream I would put on, whether it was the Pure or my IT Cosmetics, my eye serum from IT Cosmetics. So I just put my moisturizer on around my eyes. I don't know if I needed to do that. I felt really good. I could immediately, now this is a week-long process and I think after the first week of using this, then you would reuse it again, you know, like continuing maybe once a week. I'm not too sure. I'd have to really follow up on that, but this really penetrates deeper into the dermis and brings your product deeply into your dermis, which I really like this. So this was sent to me complimentary, not sponsored, not being paid, but I like this product. These eye patches are expensive. However, I think the results are worth it. I do. I think the results are worth it. I've had an extremely stressful time. This month has been, actually since October 1st, my life has been extremely stressful. And my eyes sometimes are the first thing that gives me a way. These are just like, just, I don't know, I don't know how to describe it. They're really beautiful. And thank you so much for sending this to me to try. I think this has been fabulous. I'm going to price it out a little bit more in detail, but I'm thinking this is a great treatment, especially if you have a lot of wrinkles and you want to be able to get some product to go in deeper into your skin. I really like it. And the next thing I wanted to tell you was I talked about the Jennie Amber. Jennie Amber had sent me a bunch of different things in PR, which I totally appreciate. Anyways, one of the things that she had sent me was this coffee gommage. Now I love gommages. I love putting a gommage on. I love, you know, I use an apple gommage. I use a whole bunch of different types of gommages that I've had over the course of time, because I feel it does bring your dry, take your dry skin off. This, I kind of use more as an exfoliation. It's got very fine. I'm going to take some out. It's very fine. Oh, if you can, well, it's going to be, but I'll make a mess. It's got very fine little granulars. And you can't really see it, but very fine little granulars of, of like coffee. What you do on your clean, washed skin is you put this on like a layer all over your skin. And I like a gommage where you just start to gently rub. You can leave this on for like 10 minutes, if you want, or five, depending on your timeframe. And then you can massage it and then you can rinse it off. And holy cow is my skin. After I take this off, my skin feels so good. I use this in the morning. So this is the perfect complimentary product for me in the morning because it complements everything I'm doing. I wash my face. I pat my face dry. I put this on. I put a nice little layer of it on, not super thick, but enough you can see that I have it on. You can see a little brown, dotty thingies and all that stuff.  And then when I've washed it off, then I normally will go in for my red light therapy on my trophy skin, which I absolutely love doing every morning. And that's my procedure. I really like that morning procedure. I don't use it any other time, but in the morning. So I suppose you could do it at night as well. It just, for me, it works best in my morning routine because by that time I put on my serums and my CBD oil. My canvas is really clean, really smooth, and perfect setting for my makeup. So I really love this a lot. And this was sent to me originally from Jin Amber as a part of a PR package with a couple of other products that I will talk about. But this has got to be hands down my best Gamaj that I've ever had. I really like this a lot. Really like this a lot. It works perfect for me. So super excited about my active layer for my eyes, my Gamaj for my skin, and a couple of these gifts, these items that were sent to me from Octoly and the company for great gift ideas. I just think that they're awesome. And what do you think guys? Anyways, update on my dad. My dad is back in the hospital. I brought him in yesterday. My husband and I, we brought him in yesterday morning, and I was really hoping he would come home today, but that's not happening. So he's in the hospital today. I don't quite know how long this is being filmed on Sunday, December 15th, and I'm hoping to premiere this tonight if I get it set up right away. But my dad, he's not really doing well. So he's in the hospital. I'm hoping that he comes home soon. And yeah, just send your prayers guys. I really would appreciate it. Thank you all so much. Oh, I should also tell you because everyone almost says on my head today is my Raquel Welch, and this is editor's pick in the color Shaded Cappuccino. I like this wig a lot. I do wear a lot of wigs on my videos. I sometimes wear a topper on my video. I sometimes wear hair extensions from Irresistible May. I wear a lot of different hair enhancements. And then many times I have my own natural hair. It's just a little bit more of a warmer type of a color and more of a weedy warmer color than this is a very cool shade, Shaded Cappuccino. And my hair is thinner than obviously these wigs. But I'm also going to have a little a wig chat video coming up because I was sort of Marlene Fab and Glam had talked about her wigs, and she had got a number of questions. So I'm going to do that video for you guys as well, so you can see it as well as my favorites of 2019. So I'm sure this is super long.  Thank you guys so much for watching and please continue praying us for my dad. I truly appreciate it. Bye, guys.


Welcome to this course on transition metal organometallics in catalysis and biology. In this series of lecture, of late we are discussing oligomerization of alkenes and alkynes topic, and in that we have discussed about four kinds of oligomerization reaction starting with ethylene oligomerization. And this we have discussed with regard to shell higher olefin process or the shop process, which uses the nickel catalyst for carrying out this ethylene oligomerization. The main drawback, even though this is an industrial scale process, the main drawback is that it is not selective in the sense that it produces a broad range of distributions of ethylene oligomers of various chain length. This shop is an industrial process that includes ethylene oligomerization along with olefin isomerization and olefin metathesis together they constitute the process of shop, which is shell higher olefin process. Subsequently, we have also discussed another interesting reaction, which is ethylene trimerization, and this is done very selectively in which ethylene is trimerized to give one hexene, and this is a process that uses early transition metal Tantalum 3 catalyst for carrying out this one hexene at trimerization. The subsequent that we have also discussed another topic, which is a dimerization of propene dimerization, and this produces hexenes of different substitutions, and these branched hexenes when hydrogenated give a high quality petrol of very high anti-knocking attributes, and this also uses a nickel catalyst for carrying out such kind of transformation. Now, with this being discussed today, we are going to proceed further, and then we are going to discuss another interesting reaction, which is cyclotrimerization of butadiene, or maybe we can call it for the sake of butadiene cyclotrimerization. This produces cyclo-octa-dodeca-triene, and uses also a nickel catalyst. Now, if one were to look, we are going to be discussing about this topic in as a part of today's class. Now, in this connection, it is worth noting that if one were to look at all these oligomerization process, for example oligomerization, trimerization, drymerization, cyclotimerization, all of these process, then one would see that the metal of choice for such process is in fact nickel, which is a late transition metal, and also supposedly very electron rich. Now, this is an interesting observation as well as correlation that comes out of these oligomerization reactions. What it says is that olefin oligomerization is usually favored by electron rich late transition metals, whereas olefin polymerization is favored by early transition metal electron deficient early transition metals. This is a conventional wisdom in the area of olefin oligomerization and polymerization. From this perspective, this ethylene trimerization with tantalum III, which is an early transition metal stands out in the sense that there are some examples of even lower degree of polymerization like trimerization happening with electron deficient metal like tantalum. But note that the oxidation state of tantalum is not 5 and 3, so hence it is not really very electron deficient as it would have been if it were in the plus 5 oxidation state. Now, with that, we will be able to focus on today's discussion, which would be centered around this butadiene cyclotrimerization reaction and look at various ways that they form. One thing to note that in terms of application, before I proceed further in terms of application, this shop is where applied for preparing detergent ingredients application in the detergent industry, whereas this propene dimerization giving hexane branches, these are in automobile because they are used for producing petrol of high quality anti-knocking agents. This is an application in auto industry and this ethylene trimerization is providing very selective one-hexane, they are also used for commercial purpose. Also to note that this particular reaction which is propene dimerization having applications in high quality petrol of anti-knocking capacity, the activity of these catalysts is extremely high, the turnover number is quite comparable to that of a biological enzyme like catalase that carry out these kind of transformations. Having said that, here we have a system which is extremely efficient and has a very high turnover number with respect to similar to that or comparable to that of an enzyme catalase reaction. From that perspective, this catalyst or this process is quite remarkable fit that demonstrate the capability of organometallic catalysis in the world of chemical transformation. With that discussion, let us move on to this topic of today's discussion which is cyclotrimerization of butadiene. What we are going to primarily focus on is the mechanism in which how it works. The precursor is a nickel to allyl complex, this allyl complex that is the catalyst precursor and the oxidation state over here is a nickel 2. That in presence of butadiene undergoes reductive elimination of the two allyl moiety to give a diallyl compound as is shown here. The reductive elimination happens between this and this resulting in diallyl compound as is shown over here and it gives this nickel 0 species with 2 butadiene. So the oxidation state for this species is a nickel 0. Now that subsequently reacts with butadiene to give the species which is shown over here. Now this is the oxidation addition reaction of 2 butadiene moiety to form this b-sallyl ligand and the oxidation state of the nickel has become nickel 2 as a result of this oxidation reaction. Now this is in equilibrium this species which is a sigma bond and this is a pi bond which are now separated and at a very low temperature greater than minus 40 degree centigrade, the second insertion happens on to this ligand giving rise to this nickel 2 species which also is nickel 2 and then this is an important species which subsequently tremorizes at reaction above minus 40 degree centigrade to give the corresponding nickel 0. So this is a sort of reductive elimination process to give the nickel 0 species as is shown here and this is called nickel and this is a nickel 0 species which finally eliminates the butadiene tremor to give this cyclic tremor. This is called trans trans trans 159 cyclo dodeca triene. This gives cyclo dodeca triene and this butadiene 2 of them then enters the catalytic cycle. This is an interesting mechanism which has been proposed by Wilke in 1960 and this involves the formation of nickel as is shown over here, so this involves formation of nickel as is shown over here. The main feature is the transformation from nickel 2 into the catalytic cycle as well as nickel 0 or the nickel nickel in the 2 of the catalytic cycle. The other important thing is that these particular species was confirmed by preparing it separately and entering the catalytic cycle through these species which also gave the identical cyclo tremorized products. This is indeed a very good reaction that has been successfully carried out in which butadiene can be tremorized to give trans trans trans 159 cyclo dodeca triene as is shown over here. So, the key features of these cyclo tremorization reaction is given below the key features. The number one of the pre-catalyst is a bicellular complex of nickel. Then the second thing is the mechanism was validated by independently preparing one of the intermediate and then successfully entering the catalytic cycle. So another important attribute of this mechanism is for the metal for nickel change in coordination number from 3 to 4 and the oxidation state 0 to 2 are observed and the last but a very important attribute is nickel in nickel 0 stabilized by donor ligands are observed. These are the key attributes of this cyclo tremorization process which shows the feasibility of this nice reaction through the metal undergoing flexible displaying flexible coordination mode by changing the coordination number from 3 to 4 as well as flexible oxidation state by changing the oxidation state from 0 to 2 in the process naked nickel stabilized by alkene donors are formed and they are part of the catalytic cycle. Lastly the catalytic cycle is even validated by entering the catalytic cycle through one of the catalytic intermediates which were prepared independently. Now having said this even though this was a very nice and beautiful reaction in terms of the applications of organometallic catalysis are concerned however this reaction is not being used in industrial scale for producing this cyclo-dodeca trin or trimer of butadiene and this cyclo-dodeca trin in industry is prepared by Ziegler-Nutter process as is shown over here cyclo-dodeca trimerization of butadiene in industrial scale process use Ziegler-Nutter catalysis and this is shown below 3 butadiene with titanium tetrachloride R2L2Cl3 and this gives this cis trans trans 159 cyclo-dodeca trin that is further hydrogenated and then finally in presence of oxygen and the second with nitric acid is produced this acid is produced in large scale about 10,000 ton per year annually. So even though this will this method of producing butadiene trimerization is a very nice beautiful method but this is not being used in industry probably because of difficulty in handling the air sensitive nature of nickel zero intermediate that is produced in the process of cyclo trimerization of butadiene and hence Ziegler-Nutter catalysis used to produce this trans cyclo butadiene then which is then hydrogenated and subsequent oxidation and nitric acid produces this diacid about 10,000 ton annually in a large industrial scale. So with this I come to the conclusion of today's lecture. In today's lecture we have looked into cyclo trimerization of butadiene in the context of various other topics we are covering along the theme of olefin and alkyne oligomerization reaction. We have looked into the mechanism as proposed by Wilkie using an nickel catalyst and then we have also looked at the alternative pathway which is used in industry using Ziegler-Nutter catalysis using titanium tetrachloride to produce the cyclo trimerization of butadiene in large scale processes for making a diacid in about bulk quantity about 10,000 ton annually. So with this I come to the conclusion again one more time of today's lecture and I look forward to taking up the topic in bit more detail little bit remains on this olefin and alkyne oligomerization reaction and subsequently we will take up olefin polymerization reaction as we meet next till then goodbye and thank you.


There are many vaccines in the pipeline now for COVID-19, and several are poised to enter the clinic following approval. But, Dr. Kanichi Masuda, a veterinarian who studies immunology at the Rikin Baton Zone Program, is working to develop a new type of vaccine. He has studied the phenomenon of zoonosis, where pathogens like the virus that causes COVID-19 move between species, and is using this knowledge to tackle the pandemic. According to Dr. Masuda, pathogenic coronaviruses have a special talent that makes them particularly dangerous. Those virus can infect the immune cells. Immune cells release lots of inflammatory agents, which cause very severe inflammation. In addition, immune system moves all the body over the body, therefore they will cause severe inflammation systemically. This makes a vaccination strategy difficult. Dr. Masuda warns that under certain conditions, mutated viruses might trigger antibody-dependent enhancement even after vaccination with current vaccines. So what can be done? The vaccine I'm doing is very special for the mutated viruses. The virus changes their surface protein, their body, very frequently. Once they change their bodies, the current processing developing vaccine would not be effective to prevent those virus infections, so that I am looking at a very conserved region, which means a common region among all the coronaviruses. Using this region, I am developing a new strategy of the vaccine to induce a new type of antibody against this specific region. At present, Dr. Masuda's team is working on experiments to develop a new vaccine. At present, Dr. Masuda's team is working toward a COVID-19 vaccine, but the approach could go beyond that. I'm working on the new type of vaccine against COVID-19, but this concept will be applicable for other viruses such as Ebola, hemorrhage viruses, and also the Deng hemorrhage virus. Those viruses have similar genesis, which means that they can affect the macrophages.


The film opens with Arthur Spiderwick walking hurriedly into his study. The room is shelved with bugs and odd creatures and jars. He begins to frantically put together a book, and when he binds it, and stamps his mark onto the cover, a strange beastly sound is heard outside, creatures of all sorts groaning. 80 years later, the Grace family twins, Jared, and Simon, their sister Mallory, and their mom, Helen, have recently moved from New York to the Spiderwick estate, because of the recent divorce of the parents. While Simon, Mallory, and Helen are excited, Jared hates the move, and refuses to talk to anyone. Inside, Helen and Simon hear footsteps, but see no one in the dark. While they turn the lights on, Mallory and Jared get into a fight, as Mallory, who takes fencing, whips Jared with her sword, she wants the move to work, even if Jared doesn't. Jared is left alone later outside, and hurriedly runs inside when he hears sounds in the bushes. In the boy's bedroom, Jared assures Simon that their dad is coming for them. There is salt all over the window sills, and there is a picture of Arthur's daughter Aunt Lucinda, as a little girl. She was taken to an asylum when she claimed her father was kidnapped by fairies. Lucinda was the last one to live in the house before she was taken. At dinner, mom finds the kitchen packed with honey and tomato sauce. Mallory can't find her fencing award medal, and mom can't find her car keys. After a brief argument among the siblings, Helen claims that this is not how the family will work. Mallory and Simon get up from the table, and mom receives a call from her ex-husband. Jared is overjoyed by the call, and dad promises to pick up Jared soon. After hanging up, Jared accuses Helen of not allowing dad to see them. He then hears sounds in the wall, and begins to poke holes in the wall with a broom. His mom thinks he is simply having anger issues again, but Jared claims he isn't. Mallory and Simon appear, and hear the sounds as well. Mallory hits the wall hard with the broom, and an entire section of the wall collapses.  Two of them are Mallory's metal and mom's keys. Mallory accuses Jared of stealing them, and leaves with Simon.  Jared finds odd pictures and books in the study, and opens a chest to find a bound leather book. It is titled, Arthur Spiderwick's Field Guide to the Fantastical World Around You. After finding the book, Jared hears sounds and sees something written in the dust, Jared Grace, leave this place. Jared quickly retreats downstairs, and realizes everyone is asleep. He wakes Simon up for the cool news, but his twin brother doesn't seem to care. Jared begins to read the book in bed, first ignoring a note that commands Jared not to read the book. As Jared tears off the binding, he hears roars of spiritual entities outside. He climbs inside a footlocker, and reads in there with a flashlight. A montage shows Arthur Spiderwick revealing his life of putting together a book of all the unseen and visible creatures around us. He reveals how some are kind, but some want to simply obliterate all things, such as the evil ogre, Mulbaroth. He is shown to be a shapeshifter. In the montage, we watch an evil raven fly towards Arthur, and we hear a raven's cry in the house. Jared stops reading, and climbs out of the footlocker to hear a blood-curling scream echoing through the house. It is Mallory. In her room, her long hair has been tied to the bed post, and she yells at Jared for doing so. Jared yells back, saying he didn't do it. No one believes him, except Simon. The next day, Mallory is practicing fencing with Simon in the yard. Jared comes out to ask Simon what a piece means, and Mallory yells at him again for tying her hair. As Jared stands in the yard, reading the guide, he senses something crashing into an invisible wall towards him. Later, Jared makes a new nest for the brownie of the house, a creature mentioned in the book. The brownie's nest was behind the wall, but destroyed when Mallory wrecked it. Jared lures the creature in with honey and crackers, and falls asleep. He wakes to find the honey and crackers missing, and discovers the small creature, an elf face, small clothes, and pointy ears. This is ThimbleTak, who runs away when discovered. ThimbleTak eventually reveals himself, and begins to turn sour when he realizes the guide was opened by Jared. He turns into a fat green bogart, and hurls stuff at Jared. Jared calms him down with honey. ThimbleTak explains how Arthur wanted the book safe forever, and then Jared sees Simon in the yard, looking for his cat. Suddenly, Simon is grabbed by invisible beings, and dragged away. ThimbleTak gives Jared the seeing stone ring, so he can see invisible creatures. Jared sees short, menacing goblins, carrying Simon away. Jared runs into the forest, looking for Simon. He finds a campfire, with hanging cages built around it. In one cage, he finds Hogsquill, a pig-like creature who gives Jared the sight by spitting into his ice, so he can see the creatures without the stone ring. Jared wants to free Simon above all, and Hogsquill runs away. Simon, however, is brought into the campfire, where an old man interrogates him. He asks Simon if he or anyone he knows has the field guide. Simon says he knows who, and goes back to the house to get it. Jared confronts him on the way, and the two fight. Jared saw that the old man turned into Mulgroth, and that they will all be killed anyway. As they fight, red cap, the general of the goblins, sees the book and lunges for it. The twins run away, back to the house. Jared and Simon retreat inside a protective circle of mushrooms surrounding the house, and warn Mallory outside the circle to come in. She doesn't listen, and is attacked by goblins. She sees green blood on her sword, and Jared gives her the seeing stone so she can see the goblins. After slicing up some more, and leaving red cape with only one eye. She is pulled by the brothers into the house. The house is now surrounded by goblins, and mom is at work, so she can't help the situation. After tending to some bite marks on Simon's leg, Mallory and Jared argue about what to do. Mallory meets Thimble-Tac at this time, rather humorously.  But the fire goes off and the book is intact, as the goblins together chance book name. Simon comes up with a plan, that the two should visit Lucinda at the asylum, since she was telling the truth. Thimble-Tac persuades Jared to keep the book inside the house, and Jared and Mallory take a shortcut through the backyard and into the sewer, while Simon distracts the goblins at the front. However, red cap sees the two making off, and chases them. The two reach the sewer just in time, and follow a map to the city. Red cap summons a mole troll, that clumsily chases Jared and Mallory through the sewer. At the house, Simon and Thimble-Tac realize Jared took the book, and faked out Thimble-Tac with a large cookbook. Meanwhile, Jared and Mallory find their way into the city, escaping the mole troll, after it is run over by a truck driver. Mom sees them outside of her window at work, wondering what they could be up to. Inside the asylum, Jared and Mallory greet their great-aunt Lucinda. Lucinda allows them to see the fairies gathered by her window sill, and then hurried them inside when Jared reveals he has the book. Jared wants to know what to do, and Lucinda explains what happened to her father. Ina flashback, we watch Arthur making the circle, and Lucinda playing near the mushrooms, not knowing about the safety. She is attacked by goblins, and Arthur rushes to save her. In protection, Arthur is taken away by fairies while Lucinda is left to live her life fatherless. After the story, she tells the two that Arthur is still alive, and that he is in a sacred glade held captive by the sprites. Suddenly, goblins burst through the window and tear out pages of the book, and Lucinda fends them off with a handful of salt. Then, Mom comes in to find everyone screaming. On the way home, Helen accuses the two siblings that they are simply using this fantasy to find a way out of the house. Jared says Dad left because all Helen wants to do is yell at people, and says he don't want to live with her. And then slams the car door, and stomps into the house. Inside, ThimbleTac yells at Jared for taking the book, and then Jared confesses how the goblins stole pages. At the goblin camp, Mulgaroth finds the page that destroys the circle. Jared realizes to find Arthur, they must find the sacred glade, and the only way to get here is by Arthur's pet, a griffin. Half lion, and half bird. Jared summon the griffin, and the three siblings ride off to the glade, but not before Hogskwil appears again, and gives them all the sight. Griffin brings the kids to the glade, and Arthur is still there, breathing and alive. Jared tries to explain who he is and the situation, but Mallory and Simon are transfixed by a magical song of the sprites. Arthur and Jared talk about how Jared is the new book, using the knowledge to kill Mulgaroth. Jared accuses Arthur of spending his life on a book that left Lucinda fatherless. He is kept in the glade for knowing too much. Jared and the other make a quick getaway, while Arthur distracts the sprites with a fake cookbook. Arthur is surrounded and presumably killed by the fairies. That night, Jared and the other prepare to attack the goblins when they break the circle and invade. Helen comes home, after running over an invisible goblin in the yard. She is freaked out, and is only the choice to believe that everything is real. The circle is broken, and the attack begins. Goblins are killed and burned with tomato sauce, salt, and knives. They pop through floorboards, windows and everything else. Suddenly, Mulgaroth breaks in, and the fight continues as the house is smashed up. The Grace family sets up a homemade bomb with the stove and tomato sauce loaded in it. The bomb goes off, killing all the goblins. There is a sound at the door, it is Richard, Jared's dad. Jared knows the truth from Mallory, he did not intend to get back with mom and moved in with another girl. Richard has no idea what Jared wants to hear, and Jared stabs his dad through the chest. However, this is Mulgaroth, disguised as Jared's dad. Mulgaroth begins to chase Jared through the house, transforming into a snake and following him up into the study. Thimbletack defends Jared, but is simply knocked back. On the roof, the fight continues, and Jared is left hanging on for dear life. He throws the book out into the air, and Mulgaroth transforms into a raven, and flies away with the book. However, hog squeal, with an appetite for birds, eats Mulgaroth whole. Jared falls to the ground, and admits he wants to stay with mom. A few weeks later, Lucinda is let back into the estate, and meets Thimbletack again, who is in a cast for being hurt by Mulgaroth. Suddenly, a flurry of sprites appears, with Arthur. Arthur confesses he let Lucy slip away from him, and promises never again to do that. Father and daughter touch hands, and Lucy transforms into a little six-year-old again. The two walk hand-in-hand into the very world as Jared and his family walk back into the house.


Hello. How are you all? What a nice group of people. And what a nice place to be in a library, in this library. I don't know, obviously you all are library members and that's great, but every time I do a talk in a library, I always, I like to come a little bit early and I came here early today and kind of prowled around and went up to all of the floors and looked at the books just because I find the experience of being in a library so moving these days. It strikes me, it always strikes me that libraries are truly radical places. In this day and age, the fact that we have these institutions that still exist, because can you imagine if libraries cease to exist for some reason, heaven forbid, and that we had to then somehow rebuild them and try to imagine a politician these days coming up with this idea of building a multi-million dollar building and filling it with books that we will then lend to people. And they don't have to pay for membership. It's not like a gym membership or something that you have to pay for. It just strikes me as being deeply subversive and anti-capitalist and really kind of great. So thank you for the libraries, you know.


This is stock number 11318. We are here at Summit Automotive in Fond du Lac, Wisconsin. You're new and used heavy-duty truck headquarters. Today we are checking out this super rare 2013 Chevy Silverado 3500 extended cab long box dual rear wheel. This is an LT1. It has the 6-liter V8 gas motor. This truck has been fully safety and inspected by our service shop. It has a fresh oil and filter change. All the fluids have been checked and topped off. And this truck is 100% ready to go. Silver Ice Metallic is the color. We shoot all of our videos in 1080p 60 frames per second. So if you have HD capabilities on your computer tablet or smartphone device turn them on right now because it is definitely your best way to check out the quality and condition of the truck before seeing it in person. And if you'd like to check out all the photos on this truck in the upper right hand part of screen is a link to our website. Click that and check us out there. Firestone Transforce HT LT235 80R17 tires. And these tires are pretty new on here. I would say 80 to 90 percent of the tread left on them. Framing underbodies in pretty nice shape. This truck was owned in Indiana and Illinois its whole life. Front fenders in excellent shape. Headlight lenses are crystal clear and the front bumper is in really nice shape. I didn't see any major dents or dings on there. And the hood is in really nice condition as well. Didn't see any cracks or anything in the front grill. Passengers side front fender is in excellent shape as well. And the passenger side wheel simulator is in pretty nice condition too. One little scratch on the hubcap there. But that's why we do the videos. We take these HD videos so if you are far away or even if you're close by and just cannot make the trip down but you're still interested in purchasing the vehicle you can see the truck, hear the truck and have confidence in the vehicle that you're looking at before you even get here so that when you do get here there's absolutely no surprises. And that is why we offer the Summit Auto Fastpass option in the upper right hand part of the screen. Another link to our website where you can apply for financing, get pre-approved, see a payment quote, even appraise a trade all from the comfort of your own home so when you get here all you have to do is drive the truck, love it, you'll be all set to go. Now the back tires are just as new as the front tires and yeah like 80 or 90% or more on these tires, very new tires on here. Frame under body's got just a little bit of surface corrosion on it but nothing too bad. The box rails is where you really want to look and make sure that those aren't rotted out which they're not, they're in really nice shape. Has all the factory exhaust and the body is in a really nice shape as well. Lower rockers are in excellent condition and it does come with some really nice Laverne step bars on here. This one also has the bed rail covers which are a nice addition. And as we come around to the back the rear bumper is in pretty nice shape. The only thing I saw was one little ding on that passenger side. Nothing too bad though. And the tailgate is in excellent condition as well. This one comes with a backflip G2 fold-up tonneau cover locking tailgate and it does have a linex spray-in bed liner, goose neck hitch and you do get seven pin wiring back here. The bed's in pretty nice shape and it's pretty clean. Tailgate shuts nice and solidly and as you go down the driver's side just as clean as that passenger side. No dents or dings on that box. Looks really good and the back wheel simulator is in nice condition as well. The rest of the truck looks really good. Comes with the telescopic tow mirrors with the built-in directional signals. They telescope out like that. They also fold in. They go nice and smoothly. Laverne steps are in nice shape. Inside it comes with black leather interior. These are CATSKIN leather seats. Kind of the leader in aftermarket leather. No rips or tears on there. Both of these front seats are heated. You get a power driver seat, weather tech floor mats throughout on this truck. Has the factory brake controller, auto headlamps, power windows, power locks and power mirrors. As long as we're right here I'll show you the back seats are just as nice as the front seats. It does come with the latch child safety system and it does have factory all-weather floor mats back here. You get a storage bin underneath the back seats which is really nice. Stuff's not gonna roll around and get lost back here. I like these doors on the extended cabs on the Chevy's. They open up all the way so that gives you easy access to the back and these back windows are power so they do power roll down. Bottoms of the doors all look really good. I didn't see any corrosion on them and we'll hop inside here and check out the miles and everything. You can see that this one has 65,604 miles. You do get a compass and temperature display. Instrument cluster is very nice and clean. Comes with the leather wrapped steering wheel cruise controls on the left there. You do get the six-speed automatic transmission with the optional tap shift. Turned-out four-wheel-drive comes with the CD player with AM, FM and Sirius XM radio capabilities and those outside mirrors are heated. There's your climate controls right there. We have the all-weather floor mat that goes to the passenger side as well and the passenger side seat no rips or tears on there. Very nice condition. The headliner is in nice shape and you do get map lights up there and it does come with on-star capabilities in that rear of a mirror. We'll take a quick look under the hood. I would personally like to thank you for checking out the video today and hopefully from this HD video you'll be able to tell just how clean this truck is all the way around inside now. Under the hood we have the six-liter VA motor and the base very clean runs very smooth. It does have an AFB cold air intake. This truck has been fully safe and inspected by our service shop as a fresh oil and filter change. All the fluids have been checked and topped off and this truck is 100% ready to go. I would highly recommend it from a quality and condition standpoint and to see more pictures of this truck or one of our other 450 new and used cars, trucks, SUVs, minivans, Wranglers, half tons, three-quarter tons, one tons. You name it, we have it. Go to our website www.summitauto.com. Full pictures and descriptions of every single vehicle from two locations all at summitauto.com and if you'd like to check out more HD videos you can go to youtube.com slash summitauto. Remember to like, subscribe, and share on this video and all the videos that you see there. In fact in a second you will see a link to subscribe to our YouTube channel on your lefty link to more Chevy Silverado videos like this one on your right and if you haven't been our website on the bottom link to this vehicle on our website click those check us out and we really look forward to helping you with this super clean 2013 Chevy Silverado 3500 extended cab long box dual rear wheel with the six liter gas and silver ice metallic. Thanks again for checking out the video.


Baw, what's up everybody once again is Brand Man Sean and you can thank this video to Big Bank Reads because he was basically like yo people always say use influencers to get your stuff out there but how do you find influencers? Let's talk about that. We can start by defining what an influencer is. It's somebody who has an authority or influence over others in a group and in each group there's varying levels of influence in that group but that could be a dad over his family. A dad could either inspire his family to do something and maybe he can even make and demand that somebody do something and then you have the popular kids at high school or there's always popular people in whatever environment you are. A lot of them inspire others to do things like them because they might have this cool magnetism about them and other people want to have that. A lot of celebrities in that sense are influencers. You have a lot of influencers around you. A lot of people that you follow that you don't necessarily know are probably influencers in some form or fashion.  They're a gaming influencer. Whether they leverage that influencer not as a whole another story but you want to get to that leverage and use that leverage for yourself. If you can't find an influencer do a thought experiment and say who's a pin to do I respect. Obviously we have those people directly in our lives because they influence you but then think about those other huge names. What TV shows do you watch? What new shows do you watch? Do you follow Complex Magazine? The Breakfast Club. They're all influencers right. They have a voice and they have a platform. That's big. An influencer has a platform of some sort when we're talking about what you'd be looking for. They have a platform of some sort where they can disseminate a message out to an audience. They're going to be very specific like hey we're into anime. We're guys that are into anime or we're girls into anime the higher you go the less specific it might be if the person has a million two million followers. They probably have a wide range of people that like anime but they're diverse within that love of anime. They might be girls, boys, 20 years old, 30 years old, 60, 10, all of those things but at least they have that anime commonality and with your music is typically liked by people who like anime. Find those people in an anime world.   Other than that you know what to do hit that subscribe button.


Hi everybody Sean with jaspyscasebreaks.com doing a 2020 panini select blaster one box to random team Break number 17. We're at the end of it. We would be randomizing a spot in the sterling Random hit number four. That's coming up right after this. I say would be randomizing it, but The all teams all 15 spots were bought directly by Christian Fitch So he gets all teams in this blaster break and he's guaranteed the spot for the sterling Random hit number four. It's coming up right after this. So congratulations Christian. Thank you very much Here is your select blaster Let's take a look and see what we can get for you Yeah, Mike if it's during normal business hours They would prep it or you can just give us a call between the hours of like 10 and 6 And let us know you're in the lot parking lot for curbside pickup Starting off the lord of scurril debbie gruelong joa del no cinder guard james paxton scope louise robert silver phenoms and freddy freeman That was the break. Thank you very much christian jaspyscasebreaks.com Check us out. We'll see you next time


I'm Paul Eris, I'm President of Libre, the Association of European Research Libraries, and I'm here in Amsterdam at a partners meeting for a new project we're developing on open access publishing. But what I want to talk about today is about open access, but it's a different project, a related project, to the one we've been discussing here in the capital. Europeana Newspapers is a really tremendous project bringing to the public attention and making available millions of pages of newspapers from European countries around the continent. It's a very important project for Libre because it enables our member libraries, over 400 libraries in membership of the consortium, to make available their historic material in a way in which they can't do at the minute. For a user, for a researcher, I'm a historian myself, if you want to use newspapers, you have to go to the physical library in order to see them, to search them, to study them. If you're doing European history or European research, it means you have to go to a lot of different libraries in order to make sure that you've covered all the material that you want to look at. At a stroke, Europeana Newspapers solves that problem because it's making available millions of pages of text from European libraries from their newspaper collections in one place via the Europeana portal. So it's a tremendous gift to research and to scholarship. Let me say something about newspapers in particular. Why are newspapers important? Why did Libre think that newspapers were the next type of content that we should make available? Well, one of the things you want to do if you're a historical researcher is to get as close to the subject as possible. Of course, if your subjects are still alive, if you're talking about people or events, and you can interview individuals who were there or who knew people that were there, you have that sense of immediacy and sense of contact with the subject that you're studying. For people studying older history, like myself, clearly that's not possible. So you go back to printed and written sources and that's where newspapers are important because they are a contemporary record of the events they're describing and the people who are making the news. They're the equivalent of reading a blog or a posting on Facebook today or a tweet on Twitter. Clearly in the 19th century all that technology had never been invented. So where do you go? You go to newspapers. Those are the closest records that we can find to the actual events that we want to analyse and describe. That's why Europeana Newspapers is important and that's why Libre has chosen newspapers as the topic for its next Europeana piece of work.


Hello everyone, I'm going to talk to you about hackathons, makeathons, and mapathons, and other kind of thons for humanitarian innovation, about best practices and lessons learned from people that I've interviewed and made a survey with. Why I'm talking about hackathons and makeathons, because this is one of the mechanisms in which humanitarian organizations like MSF and others can involve the broader society, the universities, the institutes, companies to help solve these operational challenges that we have. I don't know how many in here in the online audience who have done or participated in any makeathons or hackathons maybe show hands quite a lot, and I bet that most of you have heard about it. And since this is kind of a study of perspectives of people that I talked to, the online audience and everyone here, I'm happy to hear your perspectives on how you think these things work and what you can do to make them better. So please write online if you have comments on this. So what is the hackathon or makeathon or mapathon? I mean like a marathon, you know that suffix the thon. It's about something that goes on for, you know, you have some time limit and you're supposed to reach the goal. And that goal could be like a deeper understanding of things. It could be, you know, you want to prototype, you want to throw some ideas around, you want to build a network. The kind of expectations on these thons are very different, but normally you would use them as tools to accelerate humanitarian innovation. So basically doing something, let's say a lot quicker and also involving people that might take a long time to involve if you go through traditional channels and products and so on. What it usually involves is a crowd, so it could be, well the crowd could be anything from, you know, 10 people involved and 200s of people. I personally have been involved with a makeathon, which were 700 people in one day. It was quite big. You normally have a challenge or you should have a common challenge, so something that you want to address or solve. Then you have constraints. So you have 24 or 72 hours to work on this problem. And you're all in this kind of room and you might have access to some technologies or tools and you might not have access to others. There might be constraints in terms of, you know, you can spend this much money, the solution has to be this cheap or whatever. You have coaching, so you have normally a process that you follow. You have facilitators and coaches that help you through this process. You have tools and methods to help you run the thon in an effective way. And that's like a template for creative collaboration, at least in theory. So why did this study, because there is still some doubts about the usefulness and the impact of these kind of thons. So I bet that there's a lot of different experiences in the room and in the online audience as well. So it depends on what you expect from a thon. I mean, do you expect to get a final solution that you can deploy in the field? Do you expect to build a network or a community? Do you expect to get access to expertise from outside? Or do you expect prototypes or new ideas? It differs a lot. So we wanted to know more about what are the key success factors when you do these make-a-thons and hack-a-thons. What should you think about in order to get good events? And what are some common pitfalls and how can you address these? So I did an online survey with 15 respondents and also did online interviews with 13 interviewees. The focus was to get their perspectives on key outcomes. What do they expect and what do they get out of these thons? What did they consider to be the success factors? What enabled them to get the outcomes they wanted to achieve? And some maybe hard-earned lessons. So you bump into some difficulties and maybe you would do things differently the next time. So I wanted to know that as well. And I applied the ethics framework for innovation to identify and mitigate potential harms in this study. So these are the participants. So anything from the Tom Global Group, the port, humanitarian makers, field-ready, USAID, also within MSF obviously we wanted to get an outside perspective as well. Also from companies like Ericsson, that's where, for example, I had an experience of doing the make-a-thon with 700 people. So they had a technology for good day where the expectation was not to implement things in the field, so to speak, but to get the staff involved in humanitarian issues and try to crowdsource new ideas and so on. So some of the benefits that the participants reported on. Well, time-boxing, creativity and co-creation is really important because there's a saying that creativity loves constraints. So if everything is possible and you have infinite amount of time, it's very easy to like, yeah, I don't know how to do this, I don't know where to start. But if you say like you have 24 hours to do this and we put you in a room with a lot of smart people, there's an expectation that you act and that you do something. So that kind of time-boxing and doing that kind of sprint is really, really important. Another important point is that you challenge assumptions and mindsets because we assume quite a lot of things in our everyday work. So we think that people think like we do and that they have the same experiences. But when you have this diverse crowd, people from universities, the institutes, people of different age and gender and different backgrounds, you really see that, okay, we didn't really think alike and there's quite a lot of things that we assumed that weren't correct. One fundamental benefit is that you gain a deep understanding of needs because it's very difficult even if you bring in a lot of people from the outside and they have no clue about MSF or any other organization and what you're facing in operations. How could they come with a solution? And sometimes the people that know most about the needs are not always equipped to come with a solution. So that's why we need to really understand the needs. Another thing is generating a wide range of new ideas. So obviously in an ideation process creativity, it's about getting a lot of ideas. Some of them are really crazy and nuts even, but that's the point as well. You want to have something that triggers the imagination of other people. So something that I think that's completely ridiculous. Somebody else can take that and transform that into a workable idea in the end. Also we want to accelerate prototype building and testing. So it takes us from these posted notes and conversations into building prototypes. And if we build prototypes, we can test those and then we can get feedback from that. So it accelerates learning. This point with moving from thinking to doing, I think it's really, really strong. Because I think everyone has been involved in conversations, discussions, creative sessions, workshops. You know, this is really nice. This is really good. But then when you move out of that, it's just, yeah, you go back to your normal day and your normal working, you don't really act on it. Because it was a fun creative session, but there's no action afterwards. And when you move from thinking to doing, you're actually starting that and starting to push that ball forward and actually creating momentum. You can also raise awareness of important issues. You don't have to perhaps get a final solution in the end. But you might get people in board of society and institutes and universities to get aware of the challenges that you're facing. And they might have solutions. They might have networks or expertise that you need. But not always about the solution. And when you establish that shared sense of urgency, when people see that there is a need and we know where we are, we know where we want to go, then it's quite difficult to walk out of that workshop or event or a thon and say, I'm not going to do anything about it. So when you have established this, people are really eager to contribute and act on it. Another important part is forging external relationships. Because when you've found out that this is what we want to do, you usually find out that we can't do this on our own. We see it in the work we do in MSF that we need to find partnerships and relationships with outside partners in order to create these solutions. And that's how these makeathons and hackathons and thons can help us because we can invite people around this common cause. And even deeper than that, forming sustainable communities of people that are ready to help. So whenever you call on them, they are ready to lend you a helping hand or ask around in their networks. Is there anybody that can help us to solve these issues? So it's not only about the solution but also the relationships and communities we form while doing these things. I didn't look at the time. How am I doing on time? A few minutes. That's good. Classic. Strong commitment from leadership is really, really important because it's not only about committing to 24 or 48 hours. You need to commit to the planning, the careful planning in the beginning and the follow up. What do we do with these results afterwards? Also it needs careful scoping. You can't come and say, code for 24 hours, do what you want. It doesn't really work. You need to really carefully plan and scope this process. And proactive facilitation and coaching. It doesn't solve itself if you just throw smart people in the room because some might come off track and you need to help them up and some are afraid to push the boundaries and they are in the comfort zones. You need to push them out of the comfort zone. You need to document process and outcomes so somebody might pick up on this. It might not be the same team. Somebody else needs to pick up on it. If you don't have the process and outcomes documented, it's not going to work. And current diversity in all kinds is super important because consensus and having people that think alike is not good for creativity. Having subject matters on site is one of the most important things because it's not only having the subject from the beginning but actually having people involved in giving feedback to prototypes and such. That's really crucial. The final parts. You need to avoid one and done. You need to understand that this is not about the workshop, it's about how you continue and get the support to continue working this. It's iterative. It's not only about one solution but how you develop that further and have feedback loops. The paralysis of unlimited opportunity is the scoping. You cannot come with a blank sheet of paper because people will feel paralyzed almost. You need a strong scope. You can have cool gadgets in your workshops but if you put a drone there or VR glasses, they're going to use it. So be careful because sometimes they just okay, let's use these VR glasses for anything. So sometimes you want to use it to spur imagination, sometimes not. Conclusion. Negotiate expectations. Involve need knowers throughout the process. Secure ownership of outcomes. Post event. Careful planning and facilitation. I want to thank obviously everyone that participated in the study and the editorial committee of MSF Scientific Days who helped out with contacts. And that's it. Thank you very much. Any questions of clarity for Andreas? No. Sara. Sara, Venice, Manson, UK. You mentioned when the important thing was getting a deep understanding of needs. I wondered if that also involved getting a deep understanding of what was already out there and how this might fit into the overall cycle. I think that's one of the problems. Let's solve X in a thon.  But then if you come with a solution, let's throw a drone in there and do something. No, you're not even allowed to have drones in this country or bring them to the country. It's going to die. The same thing with if you don't know what's out in terms of available technology, then you might create something that's already existing. And it's very difficult to do that in 24 hours. You might need to do preparation work to understand what's benchmark technologies and look at tech and that kind of stuff. So it's very important that you prepare before so you just don't go into the room and let's create something new with these cool gadgets. Textning och gråter www.btistudios.com


Mae greetedio yn beth. Mae Prydysgettargym Brief. Fe groes am ei awn i'n echymdeiaeth byddai. Felly yn oed iawn hynny yn oed o'r pargu sydd wedi eu gwneud y panysgogol aum gan y gibtane Fe fy mod i'r Prydysgettargym께~! Mae'n rhaid i'wnghwyl ardi wrthfer, darwch arniot, rwy'n rhaid i chi'n rhaid. Pen i'n rhaid i chi'n rhaid i chi'n rhaid. Dyna'n gael'r hwn. Rwy'n gweithio i chi, i chi, i chi'n gweld a'u cefnwyr o ffrif. Dwi'n hyn o'n meddwl yma. Wrth iddo fy nghymru, o'i eich cyd-degaf. Rydw i chi'n mynd i chi, a rydw i'n mynd i chi gwych. Rydw i chi'n meddwl i gweithio i chi'ch cyd-degaf. Dyma'r ddweudio bod ydych yn fawr i gymryd i gyd yn angedusio. Cyfnodd maeth yn podemos yw hefyd yn y Reporol, a pob ddweudio bodach yn holygu'r hyfforddiad.yswn ni'n meddwl ychydig, a mae'n gofyn ni'n meddwl i'r prif. Ond o'r ddadfodd o'n fan ei mewn cofnodd y ffarsol yma, mae'n gofynio'n gofynig sy'n cydd yn ystod yn teimlo wedi'i bod yn cael ei defnyddio. Na, ond, mae'n beth oedd City rydyn ni'n bwysig. Mae'n bwysig ar ystod. Mae'n bwysig rydyn ni'n bwysig ac mae'n bwysig. Mae'n bwysig yn wedi ddiweddol. Mae hefyd yn ddod, ac mae'n effaithu'n gwoesnek. Mae'n bwysig yn dda. Mae'n bwysig yn dda. Dyma'r managesu maen nhw? Mae'n bwysig yn gwybod i weithio'r llwyster.  Rhyw oedd am si'n cael ei nifer? Rhyw oeddwn yn fath gennym, roes ni ddim yn dda. Fe allwn yn gwneud,恐ff yma'n ni. Mae Manchester, Mae Lodd yn ddim yn gweithio'r Ymlaen. Ieithio mewn'r Llywodraeth? Felly mae'n ddefnyddio'r Llywodraeth. Rwy'n golygu iddo yn chi'n mu wnes peirio i'r ffordd. Ond ym mynd i'n ymல, Cachar, ond it was all, they'll never get him on all this. It was like, give it a couple of years and they'll start getting those players and they did. It's different for us because I just don't think we, you're right, we haven't had like a clear path yet and we've settled for a lot of average players because we haven't stuck in there for the other players. I think for someone like me, let's do dinye, I think. I think dinye seems like a hard working sort of honest kid who's found themselves in a good position and gone to Barcelona. I think for somebody, me'll think, well I can rebuild my career. Minister Premier League. Minister Premier League. Mean is probably thinking, well I've just played in a World Cup on the top of where I am. There's talk of me playing for Leon in the Champions League, the Champions League would be the big thing there, man United. But if those clubs are not really showing the intent, Evan is showing. Cos he'll leave Barcelona, won't he? I'm sure of it. So if Evan is still round, stands for Deadline Day and they're like, still here lad, we're still here, we've took that gamble on you. We've took that gamble on you. You might just have to go, well I'm just going to have to go there, aren't I? And his agent will be going, just go there for a year, see what happens. Where's Kei Sinario? You'll sell here and you'll get a move somewhere else. But it's this idea that you're right, fans are like, well he's not, we'll never be able to sign him because of this. There's a lot of reasons why we might be able to sign him. You're right, you're right. Why would he want to sign for Evan? What are Evan to him? They're nothing. But on the flip side of that, if Evan, I've got a man like Brantz who is well-versed in negotiations and the art of negotiations and went to walk away and went, see this is what I find really interesting about Brantz. I think Evan, under less experienced people, number one, I think we've would have paid the money for Tainey. I really do. I think last summer we would have paid the money for Tainey. And loads of people might have said we should have just paid the money for Tainey. But these people don't believe that. I think now what we've got at the club, and ultimately we'll see what happens over time, but I think we've got people at the club now who understand the art of negotiation. I think Brantz understands how it all works. I think he knows, and I think he's got a lot more context than Steve Walsh, which I know that's difficult to believe. But I think he's got a lot more... I think this is what's been... Do you believe Steve Walsh would be going up to Barcelona, going up to Barcelona on a place 12 months ago? Well he might have taken up with a briefcase with sunglasses on, like he did in Italy. But that was just because Basie was on it all the time. He went to FAC, a FAC find in Michigan it was. What did he find? If he went to Milan, he went to the wrong place, because they sent a baruchy back to Milan. They're just sending everyone. But I think with Brantz, I think we've got a man who understands the art of doing the deal in football, and I think he knows there's a time to walk away from the deal, but that hasn't happened yet. And the reason it hasn't happened yet is because it doesn't matter what Jerry and Tom think. He hasn't gone anywhere, and at some point he will have to go somewhere. And if he feels like no one else will match the offer, and that's all Barcelona gave a monkey's about, then he has to make a decision. I think we haven't even hit the point yet where the player has to make a decision. Does it give you confidence in the team he thinks? I know we both want to give the team. I think he looks like he could be a fantastic footballer. But does that give you confidence, then, in the likes of Brantz? Because last year we'd have paid £45 million of whatever Celtic wanted and 30 out of front. And you're like there'll be a section of people, a large section of people probably going, well why didn't we? But he knows the value of doing things. He's been brought in to stop us doing that. So if he looks and goes, well Celtic wanted £35 million up front plus Adon's, which would have made him £45 million for an unproven kid, and I'm getting Barcelona's left back here for £18 million. Or he's not the first choice, but he's played enough games for them. So does that give you confidence that we're on the path we thought we were going to be on almost two years ago? It gives me confidence that he knows when to do a deal and when not to do a deal. And who to do the deal with. Exactly. So we have to just trust him then? Well at this point we have to trust him but there's nothing.


Don't panic. What's up money geeks, Mr. V here. Welcome to another video guys. So in today's video We are going to talk about ticket symbol LAC, Lithium Americas. So we've actually covered this stock here on the channel. I've been giving you guys updates step by step A lot of you guys have made some profit trading this stock So there's some news that came out yesterday I want to make sure you guys have that news because it really does impact the price of the stock and a lot of People are going to eat a panic and then no start selling because they don't quite understand what's going on And so I want to make sure that you guys all have all the information to keep you guys informed But before we get started guys, if you're new to the channel We took about how to earn money how to save money how to invest and build wealth So if that's something that interests you go ahead and hit that subscribe button and your notification bell So you don't miss out on new content also guys if you really looking to help my work here The best way to do it is just to smash that like button and also share this video with somebody that you think can't find it The content useful So from the first time that we profiled this stock here on the channel that went from $11 some news came out push the stock down to about $20 and $21 and then More news came out last week that push the stock to go test $28 So a lot of you guys have made some good money, which is good because when we profile stocks like this The whole idea there is that people should make money For you know to continue to grow the account, but some news actually came out yesterday about this target I want to make sure you guys have that information and so let's jump right in there I want to show you guys exactly what the news is here. So lithium America prices 350 million on the written public offering. So what does this mean for you guys? So let's go right here and look at it What is a public offering a public offering is a sale of equity shares or other financial Instruments such as bonds to to the public in order to raise capital So these guys have seen the growth of the company They've seen that the share price continue to rise and now that they have This particular location again, I think I did a video about these guys the attacker past location in Nevada Gap permit gap approved and so they're looking the next step now is to start getting partners That they can work with to start mining and so for them they need to raise a ton of capital So selling this this offering right now is for them to raise money as you can see it clearly state that they are trying to raise about 350 million dollars with with these offering that they're doing right now So this is going to go a long way to start getting partners line up so that they can start building and Eventually start mining. So that's what I wanted to bring out. So when they do an offering like this It definitely impacts the share price. It deludes the share price So if we go back here and just kind of take a quick look here if you notice if we go back one week If you notice this is on the 15 This stock was trading at 20 dollars, right? And then look at where it went on the 19 It tested 28 dollars and then yesterday it actually pulled back down to Down to about 23 dollars and then up on it this morning and we're sitting right now at 22 dollars and some change The reason is because when their price is shares like this at 22 dollars Who I mean like nobody wants to see the update everybody's selling to buy back at the bottom So that's why the share price gets deluded and so it's going to be trading right now somewhere around that 20 To 22 price range. So and most of you probably asking so now is this a good time for me to buy again The best way to look at is is if they are pricing this stock at 22 dollars Then anything under 22 dollars to me would be a good place for you to get started to get into the stock and again guys Anticipate that now that you're buying here it's going to be a little bit longer before you would see a ton of return because The next logical step is if they can find a partner that would be another catalyst that would drive this up and Eventually if they stop building and stop mining those would be catalysts that would drive this price up So again, these guys are doing this to raise capital. So at this point if you're getting into the stock I want you to get in with the mindset that this is not going to be a quick win Like we did like the two previous catalysts that we have This is going to be a little bit of a slow move now moving forward again If we hear anything that they have a partner they're working with and they start building in that location to eventually stop Mining that would be something that would be that mean it's going to make the price go up lithium America is doing this Public offering again where they're trying to raise 350 million dollars to get to the next step of this particular Company they have two major locations I like I've covered here on the channel one in Argentina and one in Nevada And so they're right now this this Nevada one just got their permit And so they want to start building in that location but yet they need to raise capital They need to find partners before they start building buying equipment and start mining So this is going to require a ton of money So this is phase one of their capital raising and imagine after this This is not going to be the end of it after this this stock would see so a little bump when you see the stock goes up To over 30 and hold somewhere around it and anticipate they'll do another public offering again to raise more money So just be aware of that when you invest So a lot of you guys if you didn't take profit I would say you can continue to add to your position But if you were one of the people that took profit now kudos to you now You can buy back and repeat the process again buy low now under that $22 price point buy low and then hope again wait for it to to write up again a little bit before You know you can make some more money So let me know in the comment section what you guys think about is again I know this is this is not good news for the stock but usually Companies do this because they need the money and so if we anticipate like we've said that this stock is gonna get to over a hundred dollars And some change They have to do this to get that money and the best way to do it is to do a public offering like this Which in most cases usually dilute the price of the the stock like we've seen already Now pushing this price back from the $28 high that we saw yesterday down to $22 and 36 cents is trading right now. So again, let me know in the comment section what you guys think I just want to make sure that you guys have this information so that for again for long-term investors All you have to do is hang in there Just keep buying as he drops and then for people that are looking to swing again. This is Buy low now and wait for that pop as soon as it pops You can take some profit and and move on so that that would be the game plan long term again We're looking this thing to be over a hundred dollars, which is In the future not anytime soon right now.