I'm not quite sure is it good evening or good afternoon. It's a minute past five I've just been sitting here listen to Helen name drop there with No, absolutely. I'm really looking forward to this as someone who kind of attempts to try and blog from time to time and gets Flustered and and and gets overwhelmed by it For someone to actually talk about how how we can actually use it in terms of scholarship and sharing and I love to do The idea of annotations so so I'm really gonna be here But I might pick her up as well and and pull the rug for if she gets a little bit too big for a boost Joking aside, no listen One of the things I love about OER is meeting some great people so I'm really looking forward to this So if you're ready Helen in your own time Thank you so much. I am very happy to be stepping into this domain When I started Excuse me the PhD program two years ago. I I Started with some metaphors and crystallization was not one So I'm happy to share this one because this one has has emerged as I've done the PhD program to this point So here in Canada we recognize and acknowledge the Traditional and indigenous keepers of the land so I'd like to acknowledge those past present and future Generations of the indigenous nations here in the Windsor area where I teach and learn This is also your invitation to continue Crystallizing my thinking as I dip further into becoming an academic and scholar. I have been working very Consciously and intentionally as an open academic and as I as I move into the PhD program I used a claim a reclaim hosting blog site and Would like you to also join if you have a hypothesis group open for any Annotations for this presentation or you can leave a comment on the blog site as well So just to frame what I'm going to talk about today I would I I think about these color kaleidoscopic glasses and thinking about how I was looking through different colors and different lenses as I was going through the coursework and the Portfolio presentation looking at different frameworks ontologies epistemologies methodologies and methods and really learning and developing my Critical digital literacies as I worked through and navigated into open spaces So it was very challenging to think differently as I was working through the coursework And you'll see that evidenced on the open domain blog site that I have Labeled step-by-step because I'm taking this PhD program one step at a time and Realizing that it's a marathon and I'm only about halfway through when I presented my comprehensive portfolio I used the reclaim hosting Scalar instance to prepare my Portfolio and we'll take a look at that in a few minutes as well. It's called into the labyrinth So as I started the PhD program my very first Challenge was to risk my my own confidence at risk and and and buck up my confidence as you might say to Share things openly and in the very first course We had to do this assignment that shaped our story and what brought us to the PhD program and those Influencers in our work So I shared on my blog site and then submitted the link to my Instructor so that they could see see the work I had produced And I had a few comments and and conversations with the instructor after the fact as I continued into the program I spent some time with a book by Deborah Lupton Ingram Newton and Pat Thompson called the digital academic and In that came out with this notion of her palm numara and it comes out of Foucault's research and It talks about becoming who you are through this act of writing. So it's self-writing is and you become transformed by doing the writing and and I really Caught that and and I've been reframing and and Revisualizing this as I've gone into the program Because I think by writing in a blog site I I Consolidate and and not harden but really shape and crystallize my thinking about certain things and Make some some conscious decisions about what but what fits for me and what doesn't So I love having fun with fractals and and I'm a Glutton for watching videos about fluid fluids and fractals and ice flows and things like that and I think about all of the ideas and the Conceptions that I've I've struggled with as I go through this PhD program. So I started with auto ethnography. I Shifted to okay ethnography in a digital world and then well, maybe after I read Catherine Croman's work Research, maybe it's ground theory and well, maybe it's phenomenology. Well, am I really doing phenomenology? And then I read Chrissy Miran's PhD and oh, well, maybe it's phenomenography And so I struggled through all of these conceptions fluidly shifting through and finding my path to what I've discovered in Post phenomenology and you can read on the blog site how that happened So as as I continue to go through Completed the coursework and then had to go through this in in our program What we call the comprehensive portfolio defense. So it's similar to Indiva defense where you have to validate what you know and and say yes, I'm ready to do this research so again a conscious decision to Use scalar and that came through some conversations I had with Julia Forsythe who at Brock University Had already done some some playing around with scalar So she encouraged me to step off the edge and jump into it and scalar because of the The media and digital literacy component of my research really fits for what I wanted to accomplish And for those who haven't seen scalar, I'm just going to very quickly Just share the So for my committee, I had to prepare I'm a video so I've shared the video but first for within scalar you have this navigation ability To pick your own pathway to pick your own way through a document So I structured the document very differently than a flat linear PDF File and shared this with my committee members so you can see that all of the pages in the document are Are highlighted Sections of the document are highlighted and you can drill down to each of the individual pages and click on that And it will link you to that page in the document that I created So all the pathways so as a as the author of this document I could strategically select pathways for the for my committee members or my readers to look at the document and Each of these pathways has a name and has specific links to pages within the document itself I was able to incorporate a vast collection of media files And you'll see through the presentation that I do a lot of graphic visualizations as a way to kind of form formalize consolidate my thinking crystallize my thinking as you will and and I was able to include those specifically on pages and and within pathways Okay, so that's the basics of What scale are does and I'll let you take a look at the video at your leisure So as I come to this point where I'm ready to do my research I needed to crystallize my conceptual understanding and This again became a process of of almost a year of thinking and rethinking and and trying to figure out so Landed on a notion that started with Laura Laura Richardson and ended up with Laura Alling said in 20 now in 2009 and she wrote this book called in Engaging crystallization in qualitative research and in this she wrote what I envisioned my my research to look like and feel like for me With my media and digital literacy background with my focus on teacher education With my passion for open education and sharing in global contexts so Ellison talks about crystallization as as beyond the the binary and and breaking cross boundaries and Multiple forms of representation so taking information and finding Breaking it outside of the the text alpha as I say alpha numeric text Boundaries and and looking at different ways of visualizing and sharing it through video through image through icon through audio So as a result of this I've crystallized my thinking about crystallization as as a way of Doing my research of doing the scholarly work that I'm doing and Ellison breaks it into different forms She talks about integrated or dendritic She talks about the epistemological structures underneath it the ontology Ontologies that that you bring into the research. She talks about how it ties neatly into different methodologies like Grounded theory as an example or ethnography as an example and And it really ties for me into my conceptualization of of things that that are Deer to my research in terms of media making and and dual coding and semiotics and Discourse analysis so those are pieces that are are built into this conceptualization of what crystallization can do and different ways that I can share But also ways to analyze data and analyze The the information that comes from the participants in the research So this is a brand new visualization and again, I'd love to see to hear some feedback on that And I continue to negotiate and I will continue to negotiate I may say that I'm crystallizing But you know, we all know that the like the snow that fell last night Snowflakes will continue to fall and will continue to crystallize. It is not a an end game I know that there will be an end game for the PhD. There will be a Viva presentation There will be a finished document that will be the crystallized But I know that everything else continues it doesn't doesn't ever really end as an academic and and I'm always Negotiating as I went into blogging and doing scale are making really critical intentional decisions About where I was going open public formal informal Where I was engaging with community where I was doing things independently or or Dynamically and this is one of those sessions that that I hope will inform my practice a little bit more So I'll can continue through your active participation and hopefully through the comments and the hypothesis annotations Just consider this as your opportunity to influence my PhD directions And and come play come play with some crystals with me As I shift from fluidity to some some form of solidity Solidarity in solidarity from clothes to open It requires that I let go of some things and it requires that I become what I might be And I appreciate your presence in this PhD journey. So thank you Can I just say a round of applause? Absolutely. I hope in your virtual rounds of applause Helen I've been sitting here thinking oh my god. My doctor was so boring I Treasure it was absolutely brilliant. I agree Laura Gibson. I really want to play with this decision continuum Absolutely that the level of genuine open scholarship and inventiveness and innovative and sharing that journey I'm genuinely sitting here. I Have to say that I am only stepping in the footsteps of the Giants who have gone before me. I I actively am supported by people like Doug Belchal or Gojia Bonnie Stewart Catherine Cronin and so many more as Examples of what's what's possible and and still having these open conversations with the goji and network folks that Really inspire and and keep me going. Yeah, that's absolutely. I'm always very ambious about the goji and Network, but I cannot if to say if you're talking about following in footsteps I tell you you're putting down some pretty impressive Footprints yourself Helen. I'm making it really really is like that Here when the breeze is saying these tools and metaphors can really help open up explorations beyond our usual reductive approaches And I think yeah, I'm in it while while writing those open up stuff and get cognitive juices going Do you find that sort of visual approach? Gets gets it in a way that writing might get suppose I think it does because There are so many people that could be writing in a particular area like ethnography or in my case I'm really digging into this post phenomenology Space and I can pull the threads and ideas together in a visualization that that would otherwise stay Isolated they would they wouldn't they there's no way to pull them together and say ah That's what they're talking about and there's the link and that's how these these ideas connect Yeah Martina MK we said, how do you know when a tart or an idea is crystallized? When I can say aha, I get it Aha Now I get it. So then it's crystallized and then it's it's it's whether whether the crystal is added to we know that snowflakes and Crystals keep adding in some cases, but but it's that that initial aha that it makes sense to me Have you had lots of oh no moments as well as a ha moments No, I was going down the whole wrong path You know, yes, yeah, Leo have my sense it reminds me of threshold concepts Yes, and thank you to Leo for for bringing that one into my my my whole crystal image Definitely, it's it's there as well. Yeah, what's the book you talked about the crystal book? Was that a ha moment? Absolutely was so and it came out of Some some research Where I was reading Laura Richardson and I really liked the the idea of crystallization They just caught my attention and then I started looking for well Is there something has had to have have been done since 2003 when she was first first introduced it So yeah, I went looking and found Laura Allen Ellington's work and she's written some some recent things that I'm digging into right now See Leo glad you glad you like the stuff I can certainly see as someone who lectures and research matters I can see you getting lots of invoices Ellen Your stocks because I think it's trying to get that that journey I think for me what really strikes is is your willingness to engage and be You know, you're not just you truly are an open researcher and you're willing to kind of go I was a phenomenologist. No, I wasn't a phenomenologist. I was a crowned a theorist and That's that's not always an easy because I think one of the problems I think when you when you read someone's thesis For someone who's new to research they think that this was a beautiful sequential journey, you know, they started at the introduction of and You're willing to to share that the messiness And that again was a real risk. So I Struggle and I still struggle with that in terms of The imposter syndrome that comes with it and then who am I to be talking about that because I don't know anything about post phenomenology And and I don't know anything about grounded theory. So why should I be writing in my blog about it? But isn't it that that willingness to do because everybody feels an imposter So I've a very few actually come out and and and and say it and I'm I'm so looking forward to here when you do your boy, but which I'm sure you would be doing and very soon I mean for that does sort of bring back. I mean Nick in some ways is the traditional research When all we talk with the other Interesting ways and yet we still reduce it to medieval technology bits of cardboard and paper Yeah, you know, it's It's quite limiting isn't it has to load beyond that. Yeah Yeah, and that's that's for my media and digital literacy background digital Technologies fluencies, I'm pushing that boundary Perfect It's anybody one final question. I'm just watching the time here I know I could sit and listen to Helen all day and I know I'm gonna be bothering her in the future there like that So no, absolutely. I mean you talk about when you go to conferences and I know I keep saying it I'm sorry, but genuinely how we are is it's a place that's Somewhere a little bit special a little bit different and you have to my mind Typify that so if we're happy enough that we've gone a little bit over our time It just people just want to join and applause again in the chat functions and stuff and just once again Helen just to say You stole the show as far as I'm concerned brilliant. Thank you so much for those kind words not at all. It's only the truth so Thanks Helen it was as mind-boggling as they expected look forward to it probably in your journey Yeah, I think a lot of people will be will be following We'll be following that journey So, yeah, lots of loads of applause here. Yeah, Christina. Yeah, Leo loads and not just one They're getting two and trees there like that. So it's really really good Lorda games.  I think it's certainly a lot of love and affection and you know, as I said, that's come across I am I don't know Deb is behind the scene now. I don't know. I'm just I'm just the monkey at the front She's the organ grinder. Yeah Okay, well, I'm good at that was brilliant Helen I love listening to you and I was absolutely thrilled to be part of this So I'm gonna play Brian Mathes' lovely funky video and then we're all done. Excellent. Well done. Thanks everyone Hmm


We talk a little bit about what was like being a foreign student at the university. I think it was extremely fun because there was a lot of different activities as well. There was a very good life, fun and work balance. There were a lot of activities organized with the career center and ASB alumni and the university as well. So I think when I joined ASB I was working but it was a very nice break to just study again and relax again and have a little bit of fun and learn a new culture. Now what about being a foreigner out in the workforce? What's that like? Firstly, I think it's very difficult to get jobs in Denmark, being a foreigner if you don't speak the language very well. But having said that, I think it is also about your attitude. And being a foreign person, I think you need to have a very open attitude towards learning the new culture and finding out on not how you can contribute first, you got to learn what is it that you want to contribute to the working culture, working force in Denmark. So you have to be very open.


Hello and welcome back to the craft box. My name is Brenton today. We're an episode a hundred and 79 of the was a 101 death walkthrough nearly 180 which is crazy But today we are in the silent market, and we're about to talk to a killer Calak Spellbinder it is good to see you on eat Tyrion Gorge I Want to help you spellbinder, but it is not within my power But Zaltana the mirror mask can open the way for you. She can be frosty So you should play to her tastes Zaltana is fond of tea a Strange delicacy from the spiral have you heard of it collect these things to impress her look around silent market for a sack of black salt and And a bowl of tumeric powder you'll need an ordinate tea set I've seen one in bastion the tea will be the hard part. However Shadow weaver vegan lime blight smuggled in a crate of mushew tea. He's here in the market.   Well, that's a good way to say they're liars I Love this game sometimes. I also hate it at times as well So yeah, if you haven't subscribed do it or not who cares, but this episode is gonna be kind of lit Probably hopefully maybe who knows Let's see Well, we've got double-fanged already 24,000 holy crab caps. What the hell is this? 24,000 that's a lot like a lot a lot We've been facing people with like 21, but not like 24 24 is a whole lot more than 21 That's kind of crazy. I don't know if we can do this. This might be a kind of hard.  That's always a good thing That's always a good thing because I always have like this bad feeling like no matter how many faints I pack we're like I have this like issue that we're gonna run out of not faints. However many prisms you pack I always have this issue that I'm gonna run out of prisms like I just have this fear of running out of prisms And one day it's gonna happen. I swear one day it's gonna happen I'll be like see I told you I should have packed more prisms. Good job Brent and then I'll be kind of sad But until that day, I mean, we're just gonna pretend that Prisms a cool.  Luckily. They can't remove blades. They can weakness and they can weakness But they can't remove blades unlike that bloody storm Storm mob that we faced the other the other day yesterday in the video yesterday Who enfeebled me four times in a row Four times in one battle like what the hell who does that thing? Who does that this day and age like seriously who enfeebles? Three pips.  No It's just simple don't enfeeble me. I don't like it when you enfeeble me. I find it very distasteful. Oh Gosh power no more molten cheeseball Oh Nice wee weakness there.  Oh, that's a shame Weakness comes in clutch sometimes not gonna lie. Oh, hello fortify I'm not worried about fortify anymore.   Hello another crowd favorite over here Gotta love that goat munk Yeah 42 okay What's this a blade? That's fine as long as you don't shield shielding would be bad. I would dislike that much Lee Great England. Oh, we're gonna just cut one of you. Hopefully we get something good next. We've got nine cards left So, yeah, we've only got two blades. I think stop redoing fortify. Honestly. It's not cool How many blades do we have two three three blades? That's cool Two enchanted and one long chanted. Okay, we will potent over on the boss I'm gonna try and one shot worth probably DNA. Let's see if that DNA can do something good. That would be Fantastic, I think Sometimes you got to show DNA a bit of love and at the moment I'm not dying too badly and if I do start dying badly, then I will obviously not DNA But you know until that day and age I really want another blade. So I'm just gonna wait for a bit Luckily we boost on both so I'm not Too upset about that one. We should do decent amount of damage to both of them, which is good Crit hello, this is gonna do a bit credit to The clutch of 709 we might have to scarecrow I Don't want to scarecrow because it doesn't last but I mean if we have to We might have to scare we need to scarecrow We need to scarecrow that is now I get the blades good job They've got no perps They can't do anything. So I'm gonna blade and then I'm gonna scarecrow if we die, then I mean That was my fault, but they have no perps Yeah, no perps the fish shields now. I'm gonna be so salty Thank goodness Four blades and They have a bit of hips they can actually hit now. So we're gonna do this get some health back Unfortunately, we can't just do that. We fizzled. No No If they kill me My good. Oh gosh, please trap please trap or something. Oh fizzle thank goodness. Oh I saw my life flash before my eyes there It's saying that we need another blade, but like we're just gonna hit anyway, you know You just got to do it sometimes we need help and we can't Dodged it anymore. We just need help. We didn't create that's even sadder We've probably got like 12% crit chance now It's been leveled up last time.  Okay That's good scarecrow. Okay Fantastic yay Take my crate of the finest tea in Mushu and be gone with you I actually do like a good glow a good glass of tea a good mug of tea. That's great Glass of tea who has a glass of tea only if it's iced jeez But no tea's great I am a tea drinker. I would say Zoltana, let's go and see you. We finished off this crafting quest. So if you haven't seen that Go and watch that one that came out yesterday morning I think yeah, well obviously yesterday morning, but like yesterday. I'm pretty sure yeah So that's cool. I just finished recording that in fact, and it isn't a long video So you should go and watch that if you have time like I think it's like four minutes So if you want to watch a four minute video before class or something go do that Look who it is. What do you need from me? Who told you I liked Mushu tea with black salt and turmeric cala clack I'll speak to him about this now. What do you want spellbinder travel to Tyrion gorge? I don't see any problem with that, but it is not my call Seek out my sister hunter Zaregovia the doom mask in the silent market. It is her jurisdiction You may have to plead your case forcefully, but I trust you'll do what's needed Hmm. Hmm. That is a lot of XP. Holy crap cakes Whoo, we're getting a lot of XP at the moment. It's fantastic. Um Let us put in another faint We use a lot of them even though we've got potent triple fainting is always great triple fainting is great If you if you have an opportunity where you can triple faint do it That's great Roslyn, hello I've been on like all day, but I haven't seen you. I was getting kind of sad And then Roslyn came online and I wasn't sad anymore Mandrake is good Very good very very good. Um, where is she? She is over this side apparently She'll be down down here. Yep. Oh, yep. She is. Hello Whoo exactly where we were but on the opposite side. Good job Um, yes, let us hit on an boop boop Three two one. Yay Let's go on and Head on inwards spellbinder. Why do you disturb me? I key to the Tyrion gate. Why would you want that? Are you conspiring with the rebels?  Um, we're going to paint Because we can 16 Wait, what 16 16 is she bad? Is she bad? I always get like really nervous when like bosses have like little health like I'm Like I get really skeptical that they're gonna do something like op or cheat even though I know this boss doesn't cheat because the first cheating boss I think is in Tyrion gorge Oh stun, hello Gotta love them stuns Stunning ice bosses thinking they're cool Roman round town hitting Little Okay, good job. Um, okay, okay Uh faint if we can do that I get really nervous when bosses don't do much health. Are you gonna tell she'll be no good She's gonna fortify though. Okay, then I see how it is faint number one Of two probably isn't she's like she seriously has no health like what? Why does she have no health? I'm worried now Am I doing something wrong? Like what? Excuse me. Excuse me. Who this? No phone who this? Bum bum bum bum uh, we're gonna discard you And we will also discard sacrifice. We will spirit blade We might actually do tonight today or this time maybe it depends if we clutch with like 300 health again If we do then I probably won't Just in case it doesn't kill when we die, but otherwise we probably will I like getting the health back from scarecrow. That's one thing that I love about scarecrow that juicy health That's a fizzle. Okay, that's cool. You can fizzle As long as I don't fizzle you can fizzle Um two blades and faint. We need a couple more things. We'll do this blade Sharpen blade. I think we didn't have one of those on before it would be awkward if we did I didn't think we had a sharpen. We should be fine. Hopefully. I don't think I did But it doesn't matter. We've got all the blades anyway, so it's fine Um just a check And just quickly check. No, we didn't.  So we should be fine Because we can always dr. Vaughn Yeah, so you can get that health back. Okay, that is four blades Can we get an enchant? That would be great colossal. Nope. We got a potent Like the cards are just falling in place so nicely like Except the enchants for hits It's like no, you cannot hit yet. You need to wait Enchant thank you two of them. Oh, we get our choice Is what we're gonna do Um, what's these? No, okay. I'm trying to stun me again. That's cool. I don't really care about that one Because you are most likely did Open up one two three four No, bye Oh nearly did She didn't mean fortify. She would have been she's so dead.  This is toast. Yeah, bye. Okay, you're bad um I mean it's going to do a lot. So Uh, we're gonna do this just in case it's going to do a lot though. Okay, 1,200. Okay. Bye And how much 900? Okay Oh, that's good. There we go I yield take the key to the tirion gate. Let me be Okay, let's go and talk to zultana Zultana unana. Yep Um, we could probably use a port over there Um, yep.  Hello Hello Hello, I assume you got what you needed. Yep, definitely Now that you've acquired a key exit the tirion gate You'll find yourself on the south rim the gorge open before you While you are out there you should keep an eye out for any rebel sign Some indication that they've passed through the area if you find any it would be a practical matter to track them down. Yes Sure Um, okay. Let us quickly hit over to tirion gorge and I think we'll end off the episode there Once we're over there just for pharma Um, so we can save tirion gorge for next time but we'll hit over there And see what it was like Um, yes Color-clack Um, we should slowly get health back and we'll also find wisps on the turn gorge. The turn gorge is really cool Stone block. Yes, please. Thank you Um, the turn gorge is cool It's like crazy place But really cool His beetle carapaces would make good cover for someone leaving a hidden message Um, we're just gonna hit over there sure Underneath this ancient beetle carapace is a half buried stone. The stone is painted with signcraft Based on what sabra taught you the signcraft says Friend go into the gorge and find the cave by overlook ledge. I will meet you there Okay, so, um This is tirion gorge. Um, a really really cool place. It's got like lots of levels Um, and basically we go all the way through there to fort ruckus I haven't actually made it there on my life. So I don't um know how far away that is but I think that is the last area of um Part one. I think or is it the I don't actually know. It's either there or Present beach, but I'm Kind of sure that it's for ruckus I'm pretty sure but I can look that up and we'll probably find out later Um, but yeah, anyway, thank you for watching remember to leave a like and subscribe if you haven't already subscribed Please do Um And remember craft outside the box


This is Conrad Nagel inviting you to stay tuned for the next half hour for one of radio's outstanding dramatic productions on Proudly We Hail Proudly We Hail. Oh another Proudly We Hail. One of radio's outstanding dramatic half-hours transcribed coast to coast in cooperation with this station and presented by your army and your Air Force From Radio City, New York Here is your host and star on Proudly We Hail, the distinguished star of the theater, screen, radio, and television Conrad Nagel Welcome again to Proudly We Hail. Our story is entitled Passage to Bombay This play is what we call in the theater an actor's story. It's a drama of thrilling mystery. The story is exciting But it's the people you'll meet that you'll remember the most Our first act curtain will rise in a few moments after this very important message Who's the smartest girl in your town? Why that bright young girl next door who just joined the WAF women in the Air Force? See her walking down the street in her smartly tailored blue uniform You'll notice she walks with pride because she knows she's doing a needed job a job that requires an all-out effort by every American If you are between the ages of 18 and 34 and can qualify your services are needed in the WAF women in the Air Force Visit your local United States Army and United States Air Force recruiting station learn all the facts today And now with your star Conrad Nagel and the role of Samuel Burke your army and your Air Force present the Proudly We Hail production Passage to Bombay Island of Ceylon hangs like a teardrop off the southeastern tip of India It's a lush mountainous island whose capital and main port is Colombo To Colombo came the schooner Mandrake her holes filled with cotton and tin from Rangoon The Mandrakes owner and master Samuel Burke was a man of education and good breeding and a shrew trader as well But more than that He was a big man who handled his crew with a firm but humane hand in a day when humanity was a condition Seldom found aboard ship. I'm off. Mr. One. Hi captain You should be able to start loading before bells the men won't be able to do much in this heat Don't press them. We're no great hurry even so we can have it done by noon tomorrow, sir That'll be time enough We plan to ship out in the evening tired Four days and hardly a breath of wind. Yeah, so I've noticed Well, we'll hope tomorrow brings an improvement. Have you taken a look at the glass, sir? I uncommon high but not uncommon to these parts I should be back by six bells perhaps sooner. Take charge. Mr. One. Hi, sir Been a pleasure to do business with you captain Burke. I think the arrangement is equitable all around any kind of luck Mr. E's we should make Bombay by the 18th Strickland will be looking for you. Oh now there's one of the matter Come in Dr. Ferrell and his daughter are here, sir. Very good. Show them in will you please? This is the matter of which I was going to speak captain. Oh good afternoon miss Farrell doctor Afternoon mr. Reeves allow me to present captain Burke of the Mandrake miss Farrell and dr. Farrell How do you do miss Ferrell a pleasure, sir? How do you do captain? Sit down one. Thank you. I Was just about to speak to captain Burke of your difficulty doctor now that you're here suppose you tell him yourself gladly Captain I and my daughter are most anxious to get to Bombay Mr. Reeves tells me that you have a fast ship much faster than the packet which I'm afraid will not be leaving before next week We should like to buy passage on your ship. No You realize the Mandrake has no accommodations for passengers. Yes, so mr. Reeves has pointed out However, we'll be glad to take whatever accommodations you can offer upon occasion We have carried a passenger to you understand that you'll be putting up with a rather rough and primitive life aboard. I Think it can be done a reason for haste is a good one captain They've just received word that my wife has been taken seriously ill. Oh, I regret sir I hope we have more favorable winds once we clear port and the weather is a bit sticky When will you be able to leave captain leaving tired tomorrow? I suggest to be aboard but two bells. That's five o'clock and Helmets will you charge for passage be no charge sir the Mandrake is bound for Bombay. It'll be no hot I wouldn't think of it sir. I'm sorry sir those the only nations under which I'll take you you're in trouble. You need help. I'm happy to assist Following days saw no change in temperature continued hot and humid but toward even tired a fitful breeze sprang up the mouth the northeast It seemed to assure some headway and perhaps a break in the weather The doctor and his daughter arrived at the dockside at the appointed time They made quite a contrast He a tall thin man with a bony for lawn looking face She a small quiet slip of a woman with large soft eyes Filled with a strange emptiness. I Gave up my cabin tour and placed her father in the ward room All secure sir. You'll fill out the log mr. Owen. This breeze won't last It may freshen. There's a nasty swell captain. She looks like lead helmsman Had her up a point Think you've been better spirits mr. Owen with a pretty young woman aboard She is a looker isn't she sir? You'll excuse me while I have a word with the Looker and her father Good evening Good evening. I hope we weren't in the way not at all doctor. We don't seem to be going very fast. I'm afraid not However, my last passenger was a minister when we needed when he prayed for it It blew up a gale Should you be tempted to pray please do so with moderation? I'm sorry. I sometimes forget. Well We'll hope the weather improves by morning. I Think we can go below now. I'm sure you must be famished. This heat doesn't exactly stimulate the appetite No, it does this swell. I'm sure you both feel better after you've eaten eaten Sweet My my daughter has a droll sense of humor. You you must excuse her We're barely making steerage way sir. I'm aware of that the glass is dropping good means a change I don't think the Mandrake takes to being be calmed nor do I sir especially with this dirty cross swell Mr. Owen what you're trying to convey is the feeling that this has all the earmarks of typhoon weather. Is that correct? I had it in mind sir. I've had it in minds since yesterday However, this is not the China's sea and you know as well as I the typhoons in this area are most uncommon I know sir, but even granting it such an occurrence is possible. We'll have apple time to put into port before it strikes Should it come out of the Arabian Sea will run before it back to Colombo Comes out of the Indian Ocean will put into a Trivandrum should it come out of the Andaman Sea will make for the locality Does that put your fears at rest mr. Rowan? I I'm sorry, sir nonsense man a good mate is an observant one It's your job to be aware of these things and to worry about them if you see fit Well, sir If I may be so bold, there's there's another matter. I'm worried about What's that the lady miss Farrell hmm at the table she seemed well I don't know, but she said things that didn't seem to make sense and she'd laugh for no reason at all Kind of gave me the creep. Yes. I can't deny that Take charge mr. Rowan There you are captain Isn't it rather late miss Farrell? No, I think it's rather early besides I get all mixed up with your bells They they don't make sense. I Thought perhaps you'd like to show me around your ship. Well This is hardly a good time for a tour miss Farrell. It's a very dark night. I know, but isn't that the best time though? I like the dark so much better than the light it hides things Have you things to hide captain? It's such a big strong-looking man even in the dark Are your arms strong captain? Now I'm teasing you. I shouldn't tease dr. Farrell. I mean father says I We're here dr. Farrell over with the mason mask. Why did you tell him? He'll only spoil things He always spoils things and I think it's time. You're in bed. It's been a long day. Yes It's been a long day such a long day And the nights are so dark and empty Good night captain. I'm Dr. Farrell. Are you awake? Yes, captain. I'm awake. I think we'd better have a talk The talk I'm not blind dr. Nor am I a fool Is it that obvious it's becoming increasingly more so? I'm the one who's a fool thinking I could deceive you is Is she Demented I'd better tell you the whole story She's not my daughter. She's the daughter-in-law of a friend of mine in Ceylon Her name is really Ellen Cartwright She and her husband and child came out for a visit a little over a year ago One day the three of them went for a sale sudden squall came up the boat capsized. She was the only survivor Never did get the complete story other than that. She saw her husband and child round The charge of course was very great Ellen was very ill for some months and when she recovered she seemed to have no memory of what had happened Those are the times. She's perfectly rational I'm afraid the association of being on board ship again has had a bad effect I'm not a doctor, but it seems obvious to me that it naturally would and I realized that but it was felt by her Family and myself that the sooner we could get her away from here back to her own people the better chance She'd have for recovery did did Reeves know about this No, I Deceived him as well How is it she plays the part of your daughter?  I Have made her believe that she is my daughter and see you were afraid to take her on the packet. Yes, I thought this would be Well better from all standpoints. How does she act when a storm comes up? Yeah, I'm afraid her actions border on the uncontrollable. There's a subconscious connection Why do you ask in other words the worst condition you could put her in would be on board ship than a storm?   I Am sorry, I've deceived you more so before this voyage is done, but I I Don't understand. Do you know anything at all of weather? No, no, I'm afraid I don't that instrument hanging there as a barometer The last two hours has been dropping steadily the sea swell has been growing more violent There's not a breath of wind and the air is thick and humid. Yes, I'd noticed but What does it mean? Mean sir if there was any breeze at all I'd come about and head back for Colombo as fast as I could We're in for a bad blow perhaps a typhoon And I don't look forward to having a mad woman aboard my ship when it comes They go starring in the role of Samuel Burton the proudly we hail production passage to Bombay will return in just a moment for the second act Here's a special message for you young women Next time you see a WAF woman in the Air Force take a good look You're looking at the smartest woman of the year in Air Force blue It isn't just the uniform. She's demonstrating her smartness in another way even more important She's found a career that means something she's serving in the world's greatest Air Force and she's proud of it She's working on equal terms with the men of the Air Force She has good pay comfortable quarters opportunities for travel and the deep sense of personal accomplishment That goes with doing a needed job. Well She's working in interesting fields as a technician in medical and dental fields in air traffic photography or one of many others She's learning new skills and liking it a lot in short. She's the smartest woman of the year If you are a young woman between 18 and 34 and can qualify you can join her in that smart uniform All you have to do is stop in at your nearest United States Army and United States Air Force recruiting station You are listening to proudly we hail and now with your star Conrad Nagel in the role of Samuel Burke We present the second act of passage to Bombay A pretty kettle of fish For some reason the praise stuck in my mind Perhaps I'd been unduly harsh to the doctor but under the circumstances I could afford him no sympathy My sympathy lay with the poor tortured woman whose sanity was balanced on a thin line Certainly topple over the brink of what was to come Through the night the glass continued to fall We could no longer hold steerage away in the ever-increasing swell was sweeping us out into the Indian Ocean The mandrake heaved uneasily Canvas limp and useless I can only hope when the wind sprang up We would have time enough to run for nager coil on the tip of the Indian mainland The Sun the next morning rose is an angry copper ball When I saw the smoky yellowish smudge of clouds off our starboard beam. I called mr. Oh into the quarter-deck alone Seemed as though our worst fears are to be confirmed. Hi, sir I want all canvas offer but are jib and topsils. They'll not last long on this I would all hands off watch battening down above and below decks when it hits. We'll try to run We may be able to stay on the edge of it. You're an optimist sir. That's right, mr. Mate you do better to have a little of it yourself. Sorry sir. Must be the heat Or the fact that I went through a typhoon. Well, then there should be nothing new about it to you It seemed to have survived it well enough. I was on land, sir There wasn't a ship in the area that wrote it out safely I Was she still asleep I believe I haven't disturbed her that's a help the winds come up. We seem to be making good time Let's hope it's good enough We're running for the tip of the Indian mainland If the full force the storm hits us before we get there we'll have no other alternative but to write it out You can't go on selling not with bare poles When we'll shred our canvas as though it were tissue paper. It's a typhoon. Yes I'll have my hands full we all will It'll be up to you to see to it that your patient is kept in a cabin. Even if you have to use force If we're caught up in the full strength of this blow it'll take all the ability of every man on this ship to see that we survive And even then our ability may not be enough It'll be your job to see that we have no outside problems to contend with that clear perfectly captain I The wind won't I don't like it make it stop laughing at me doctor She's in your care Make the wind stop Ellen my child there's nothing in the wind it won't hurt you it's going to take you home Those men been on the helm since they came on what sir have them relieved No one's to be on the helm more than two hours in a stretch. They've got to conserve our strength. Hi, sir The tops of the gun they're in shred. I'm not blind mr. Owen Have her brought into the wind. We'll have to try and ride her out as best we can All the rest of that day and on into the night we've battled the ever-increasing fury of the storm Our canvas gone. We could no longer run before its might Instead we had to turn and face its brutal force Great thunderous seas rose about us And it was more the almighty's work than our semen shift that we were not engulfed and completely swallowed up As it was an occasional wave found its mark and the man break would shudder from stem to stem and the Crushing tons of swirling water that fell upon her with unearthly force Beat into my knees gasping and choking. I would think well. This is the end She can never rise out of this but always somehow she did and I would regain my feet with the insane Gibbering wind tearing at me The men on the helm were lashed to it. I had a line around my waist tied to the main mist The rest of the crew under the mate's direction were below deck some of the pumps some of the cargo holes But every man aboard ship was fighting grimly to keep a man drake of float and as time passed It seemed as though the tide of fate had turned against us. Make your way carefully man For it holds her she's opening up The pumps are working fast enough sir. There's two feet of water and hold on hold on keep her headed up I said all right I'll have a look below Try this line around you. I'll send two new men for the helm Steady as she goes For heaven's sake don't let her fall off or we're done How fast is it rising we've got about two and a half feet in our captain have the pumps brought in from the main hole Brian bring four men. We'll get at it. Look like Steven's look that relieved them in on the helm Even with the pumps from the main hold it was a losing battle But still we had to fight it as best we could and pray that the storm would abate before the man drake became a sea coffin It was close to dawn when I left the for it hold and made my way out planning to go on deck and take over for mr.. Owen then I Suddenly thought of a doctor in his charge and felt it would be a good idea to look in on them dr. Farrell Dr. Farrell dr. Fennel you'd come.   Oh, he's in there. All right, just as quiet and peaceful Now wait a minute. Mesh may I have a look? Oh, yes Do by all means have a look Have a good look at the poor man Well if the storm was a threat to my life in this poor wild eye creature where the revolver gripped in her hand Was just as great a one and just as capricious Took every bit of nerve. I had to turn my back on her knowing she might shoot me without thought or reason Kaleid just inside the cabin door. She was right. He was lying quite still But it took only a moment to realize he wasn't dead only superficially wounded the bullet had grazed his skull I Picked him up with ease and placed him in the bunk. Why did you do that? I didn't tell you you could do that well now Now you mustn't be unkind to the dead No, you must never be unkind at them stand over there what Are you going to do I'll make you dead, too.  It's fastened to the floor.  Remember we must be kind to him.  Why should you live put down that gun put it down at once? Now you can say you've lived through two typhoons It wasn't the kind that comes out of the China sea sir We wouldn't be here now a small typhoon is better than none at all.   Rowan How's the doctor? Oh, he's got a headache, but he'll do It's the other one that I'm thinking about sir. Yes She's um She's calmer Never a word out of her. Just sits there staring at nothing The storm must have been too much for Are you sure sir that it's necessary to keep a man on watch down there at all times at all times mr.  Yes You saw the doctor's head. No, he probably did it himself sir slipping and slapping around the way we were Oh, you asked me she couldn't harm a flea, but I didn't ask you mr. Rowan You'll keep a man down there with it till we make port So it was a strange paradox to think about is now the man Drake limp painfully under shortened sail for the safety of the mainland The typhoon had nearly ended all our lives And yet as I said to oh, and I owed it mine For Ellen Cartwright had been in the act of shooting me dead When the most violent sea we had yet sustained crashed over our decks Nearly putting the man Drake on our beams end and knocking us both into a corner the blows thunder After lashing her in the ward room bunk. I'd made my way up onto the deck now. It was all but done I've not seen fit to enlighten anyone concerning my actions When we reached port they would take Ellen Cartwright to shore and out of my life She was truly a tragic and lost creature Someone to forget But I knew no matter what seas I sailed or in what kind of weather I Would never forget the look of her or Shake her mad laughter Turn in just a moment with a word about next week's show The woman in the Air Force is a woman who has found that it's smart to serve her country She wears the trim waft uniform and she has a good future in a good outfit See you're walking down the street in her smartly tailored blue uniform You'll notice she walks with pride because she knows she's doing a needed job a job that requires an all-out effort by every American If you are between the ages of 18 and 34 and can qualify your services are needed in the weft women in the Air Force Visits your local United States Army and United States Air Force recruiting station learn all the facts today This has been another program on proudly we hail presented transcribed in cooperation with this station by the United States Army and the United States Air Force recruiting service proudly we hail stars Conrad Nagel Supporting mr. Nagel and the role of Ellen Cartwright was Helen Christian This is Kenneth Banghart speaking and here again is your host and star Conrad Nagel friends We hope you'll be with us over this same station for proudly we hail next week our play takes us to Spain in 1588 for a story of Sir Francis Drake in the Spanish Armada and is entitled Hugh and cry until then Goodbye


the Hooded Cobra Commander 788 here, and this is a very quick look at the 1988 Cobra Stellar Stiletto and the pilot, the Star Viper. I mentioned in a previous video that the second to last GI Joe vehicle that I bought as a kid was the Desert Fox. Well, this was the last GI Joe vehicle that I bought as a kid back in 1988. And this, the Cobra Stellar is basically a rocket ship. It's meant to be launched into space. And I wasn't really looking for a rocket ship. I wasn't into all the space stuff that was just starting to come out around about 1987. Really wasn't my thing. But what I was looking for was a Cobra Jet. I needed to augment my Cobra Air Force. And there wasn't a lot to choose from on the shelves in 1988. So I ended up getting this one, and it served the purpose. Now the Star Viper is a pretty basic figure, mostly in black. In fact, made entirely of black plastic with a few gold and red highlights. A very, very simple figure, non-removable helmet. The Stellar Stiletto is also pretty simple. It's made almost entirely of red plastic with a little bit of gray and silver. We have a cockpit with plenty of room for the pilot in there. We have some rocket engines. We have this tail fin that flips up because you're actually supposed to launch this thing vertically like that. We have kind of a rubbery nose cone. We have a chin cannon that actually rotates. And that's a little unusual. You don't see that very often. We have four missiles, two types, but four missiles. And those have some high-tech sculpting on there. They look very futuristic, not like realistic missiles, but just kind of futuristic looking. And that's basically it. It's really a very simple vehicle. There are some good things and some bad things about the Cobra Stellar Stiletto, but I won't go into that. I'll save that for the eventual full review of this toy. But that's just a nice quick look at it for right now. I hope you enjoyed it. Keep checking back for more full Vintage GI Joe toy reviews. Thanks for watching.


Right, and as both Eric and Rudy have mentioned, this is a continuation of a discussion that began at the September council round when we brought two concepts that you approved, one that you asked us to come back and reconsider, and we previewed a few more. So I'm going to talk about the ones that didn't go through last time. This is just a reminder that everything I'm going to talk about comes out of the July 2014 strategic planning workshop we had, which covered the topics that you can see up there. In the big blue bubble is disease gene invariant discovery across architectures and across designs, clinical applications of sequencing, genome function, and related informatics and related technology development came up as well. Coming out of that wish list, and I should say, I'm going to go through this background very, very quickly because you've seen it before. But if I'm going too fast, just stop me. I'm happy to slow down. So coming out of that workshop were a list of items that participants recommended for high priority attention, again, including this area of disease gene invariant discovery, clinical applications of sequencing, creating a virtuous cycle between clinic and discovery. They identified a big need to enable capture, interpretability, and analysis of the world's sequencing data. They also thought we should pay attention, continue attention to genome function, especially related to interpretation of variance. And a few things that we didn't really expect so much came out as well. One was to produce additional very high quality human genome sequences to aid references. And another was to re-emphasize comparative and evolutionary genomics. I should say that a lot of these already have their own programs, their own centers of gravity, their own planning efforts that are ongoing. So I'm not going to talk about those further. So clinical sequencing, the informatics, and the functional genomics. And even this gold genomes methods development, which arguably falls under our technology development program, I'm not going to talk about those. But I will talk about all of these. We brought this idea in the form of these two concepts to September Council. There is RFAs on the street, as Eric mentioned, for Centers for Common Disease Genomics, and one for Centers for Mendelian Genomics. And we're looking forward to seeing the applications in April. So that brings us up to the current. I will talk today about the rest of the concepts, the genome sequencing program analysis satellites, the genome sequencing program coordinating center, which together with the first two initiatives really round out the core of the genome sequencing program. I'm also going to talk about this gold genomes idea, it's very high quality references idea, and comparative and evolutionary genomics. And here is what I said just in text format. We have the first four concepts, RFAs, being the core of the sequencing program and the two others. I'm going to talk about items three and item four separately. But I do think about them together sometimes, because they both grow out of even just a quick consideration of both the Centers for Common Disease Genomics and the Centers for Mendelian Genomics. And it's really simple. There's going to be a lot of data, and that means a lot of analysis opportunities, and that's concept three. And there's going to be a complex structure, and there will be many coordination needs. In September, as you know, I brought both of these ideas together in a single concept. And you asked us to rethink that based on a couple of things. First, there were concerns, as I understand them, there were concerns that both of these functions would be hard to get in one group. And another was simply because of the way that, because of how much data was going to be produced and the kind of data it was, we were just going to miss an opportunity for getting more diverse analyses. So that was creativity opportunity. And then there was also this opportunity to sort of disseminate the data out of the big centers faster if we had analysis, separate analysis groups. So that brings us to the Genome Sequencing Program analysis satellites concept. They were proposed and carry out novel creative analyses of the data produced by the Genome Sequencing Program as a whole. But these analyses will cut across individual projects, and there will be many projects going on within the CCDG and the CMG, different grants, and even programs. So although we want the proposal to be founded on the use of the data coming out of the program, we're not going to limit applicants to only analyzing those kinds of data. There are other programs, there are functional genomics programs, there are other big data sets sponsored by Common Fund and elsewhere at NHGRI. We want all that to be fair game. And we also want them to help with cross program analyses that we can define in advance or with the program as the program is ongoing. And we don't want them to do routine data processing. We think that's taken care of. So just to elaborate, there will be two kinds of goals. And one that the satellites have and one of these outward looking goals. And they consist of improved or novel analyses for non-automated aspects of characterizing sequence variants in the data, anything after variant calling. So that's a very sort of a lower limit. But we have particular interests and questions about association analyses and using existing functional data to help make associations, et cetera. Improving study design to increase power, other higher level analyses. We're not going to limit these. These first two bullet points, this sort of outward looking function of the satellites will be investigator driven. But then the second two bullet points have to deal with tasks that are program driven. So there are questions that go across are likely to go across the entire program. So for example, for the common disease program, when is a common disease study really comprehensive or complete? We're also interested in characterization and specification of sample sets that could serve as common controls. And we want the analysis centers to contribute some of their muscle to those cross program tasks as well. Whenever we present a concept, we like to talk about the relationship to other NHGRI activities. And that's important here. We do fund other sequence analysis activities that are investigator initiated and some that are initiated by us. For example, some of the analysis component of 1,000 genomes, the FUNVAR program, we're going to have to make sure that this is differentiated from those. We're going to have to look for overlap and try to avoid it. We will encourage proposals that will take best advantage of the genome sequencing program data and again discourage those that would do the other efforts. And of course, the satellites will be an integral part of the program as a whole. As for mechanism, we feel we need cooperative agreements to facilitate coordination. There are cooperative agreement mechanisms that allow investigator initiated components. Investigators and this is critical and I would like to hear some discussion about what the boundaries are similar to what the discussion was just before. We would like to make investigators and key personnel from the large sequencing center grants not eligible to be funded in order to encourage dissemination. But there are all kinds of variations of that can come up institutional, co-PI's, things like that. We have to think our way through. And we will write the announcement to increase the chances that each of these grantees will be working on a slightly different area of focus. We propose to fund this at $3 million per year for four years. We think this should be plenty for three to four awards. And we would like to start these as soon as possible to be in time with the rest of the program. So I'm going to stop there. There are a few council members that I talked to in advance in depth about this. I hope you all got a chance to read the concept document, but I'm going to call on them first for discussion. So I actually have to start with Joe. I had a question about the minimum or you said that the, let's say, so if the sequencing centers provide variant calls, then the analysis groups wouldn't redo that. But we already heard from Eric, I guess, about the intersection among the calls or, for example, for the AD samples. And so how will that work if you're using data from one center that has one set of calls? Yeah, the data, it's hard to say in advance without some specific examples about where it will be needed because in the ideal case, all the analysis centers, all the analysis satellites will have access to all of the data. The reality is that some of the projects are going to be like, for example, they're going to be like ADSP, they're going to have their own arrangements for a data repository. It will be possible to get the data from, in the case of it were ADSP, from GenBank and the NIA center. There may be other arrangements that are like that. There may be other times where the analysis satellites have to actually go to the centers directly to get the data. But I'm hoping that, by and large, most of it can be within these large projects and there will be provision for the data, but it is a really important problem. It grows with a number of analysis centers and it does have to be dealt with. Yeah. Dan. Well, it seems like a really trivial comment, but I dislike the word satellite. It has this sort of sense that the sequencing centers are like the center of the universe and everything revolves around them and the satellites are sort of afterthought almost. And I really think that if we're going to put all this money into genome sequencing, that this is a really, really critical initiative. And so I wonder, I just wish there was a better word. And of course, when I thought about making this comment, I thought to myself I would be smart if I had a better word and I don't. But I put that flea in your ear before the RFA gets finalized. Eric. And I have a bit of a high level comment. I'm concerned, and it's not to you, it's to us really, that we don't commoditize science too much. That really these major national initiatives, if they raise to that level that important, I think the key to their success is attention from A to Z. You know, study design, procurement of the samples, definition of the phenotype, this details of the calling, the QC, the analysis, all the way through. And if we break this up into little bitty parts and we fund those little bitty parts separately, I'm afraid we're going to lose the cohesion that would make some of these extremely difficult problems tractable. And that's not a criticism. It's an observation. So I just think we all have to be careful that we don't over commoditize this. And the other thing that happens when you do commoditize something, everybody thinks what they're doing is the most important and what the others are doing is less important. Where indeed what is important is what brings everybody together, working on that unified goal. All right. I certainly, in discussing the tasks of the CCDGs and CMGs versus analysis centers versus coordinating center, I view these as overlapping, right? I do think that the, again, the analysis satellites as they're proposed have a little bit more leeway to be more outward looking, more venturesome. I imagine that a lot of the centers are actually going to be paying attention to individual projects and some issues over. And I certainly, the way I envision this working is much the way that it already works when there's any collaboration that's functional is that everybody that's interested in a problem is working on it together. And I think exactly for the reasons that you state, that's the way to get the most out of it. Carol. So I actually had a different take on it, which is I completely agree with you, Eric, but we also need to invest money into groups that are going to take these data sets and do new novel things with them to really push the boundaries of how we use computational approaches to do data-driven science and hypothesis generation. And I think, so I think we need these innovation centers like this, these computational innovation centers to do that and they have to be funded. And I think it's important to do that in addition to funding the A to Z, the end-to-end projects. So I like the concept very much about bringing it in and expanding it. But the question is, what do you do with balancing this off with the sequencing centers, which also are going to want to analyze the data and go forward on this. And so I'm just wondering out loud if, well, you're going to have $3 million, if you will, for the general pool, for people outside of the major centers. I almost wonder if it's not worth having an additional $3 million that comes out of the centers that they then also compete. So think of it as a $6 million pool. So we get the very best ideas coming in for how to analyze the data. And looking at something like this, because I don't want to have the sequencing centers not participating, but I would like there to be some type of a competition. So the very best ideas are able to get in from both sides. And look at this as well as the standard way of looking at this from soup to nuts, like Eric was talking about. And I don't know if that makes sense. But so the idea would be that the sequencing centers are also competing for some number of dollars that are coming out of their budget for how to analyze the data. And then there's another amount that expands it beyond the sequencing centers. So in essence, you're getting a lot of good ideas that come in and you're funding across both sides and have a way of comparing them versus trying to put it together later on. Does that make sense? I think the intent makes sense to me. I immediately start thinking of mechanisms, mechanisms to do it. And I would have to think more about it. I'm not thinking about possible. Because I just hate not having the sequencing centers being able to think about some of these interesting analyses, but I would like to be able to expand it. So. But there's nothing that would prevent somebody from collaborating with somebody in a sequencing center. I think the thing was that they couldn't be the PI, but it doesn't eliminate collaboration. Is that correct? That's correct. And I mean, the sequencing centers are going to have, as part of their entry into the competition, need to demonstrate analysis capabilities anyway, right? So the way I view this RFA is as broadening the analysis group to include people that are outside of sequencing centers that can bring expertise to what are going to be very large collaborative projects anyway. We imagine there are going to be a bunch of people who want to join the analysis groups because they want to join the analysis groups. That's the way 1000 genomes and other kinds of projects have been run. So I think it's to create the infrastructure to make that happen. And so that the sequencing centers aren't potentially viewed as sort of being sequestered and sort of on their own, but rather in these kinds of worlds, as Eric was pointing out, where we really need to bring everyone together, then you're going to need to have some funds allocated to an analysis center to make that the whole consortium basically happened. But not all the analysis that's going to get done for the project is going to just be done by the people who are at the sequencing center, even at the satellite analysis sites. My guess is that these will be pretty broad, collaborative groups that are going to come together to tackle this because that's what we need to do. Elana. So as you describe the four bullet points and objectives here, the first two seem like they're largely, innovation could occur being supported by any number of mechanisms outside of this RFA. And it's the last two that are actually really relevant where added value is here because the groups would be sharing data, sharing common problems, meeting to discuss what works and what doesn't, so on. And there's a lot of precedent for that, going way back before GWAS days even, where that's really added value for exactly the reasons that were raised here, not as a replacement for what's going on in the data generators, in this case the sequencing centers, but as an adjunct to it. And that seems like, that seems really, really valuable and it adds tension and it just raises the bar for everyone. So I think that's really exciting. I think the next topic you're going to raise is the harder one because how do we get them to share those data and get them on a common footing where there is really added value here for the, to maximize what the analysts can have? But that's why I thought that a potential competition, if you will, in granting mechanism around that, you in some sense establish that as part of the review process, that instead of everybody coming together then figuring out how we're going to do this, you're having some type of a competition with the sequencing centers and with the outside centers to come up with the analysis strategy. So in essence, review is helping to drive the priority. So I think that could happen with the scheme as it exists. In fact, I'd expect some of that to happen, but you were taking it a step further and trying to raise more matching money to do that, weren't you? Which is interesting from the centers themselves. So Howard, maybe I'm not understanding you. You're talking about an initial competition or an ongoing competition because my concern is as soon as you put money up for grabs, you're not going to get people collaborating.  So I'm thinking of an initial competition. So that you're putting together, you know, think of the common fund, if you will, as an analogy. I don't know if that's a good analogy or a bad analogy of those resources being pulled out of the centers and that they're competing for those and then the people that aren't part of that are also competing for those dollars and we're getting the very best analysis ideas from inside and outside the community that are reviewed, they're competitive and then from that point then we can start going forward. So I know they have analytical capabilities. I mean, that's why we want these people to go forward on this, but I'm just trying to figure out a way to do it a little bit differently and maybe it's a bad idea. Yeah, and Howard, just to make sure I have it right, you're talking about some portion of the funds being reviewed internally to the system rather than bringing in additional groups. I said three to four additional groups because I'm worried that if we go to five or six or seven it will be very hard to coordinate. So. But Adam, in this context, it might be worth discussing the timing. You know, like when will these, what will we know about the production centers at the time people are applying for this? Yeah. Yeah. So that's one of the reasons, one of the things that makes it tough is it would be in some ways easier to know if you knew, if we knew what all the projects were ahead of time. And we may not have that luxury. I actually had two questions. One is, is the TCGA a good model or a counter model or anything for this business of having the sequencing centers doing some work on the analysis, but at the same time having a central group that's pulling things together and also going beyond just what the sequencing centers are doing? Yeah. Actually, I think scientifically, I often think about the pan-cancer analysis as being an example of cross-cutting analyses that I know how they arose, but it's the kind of across-disease analysis that I find very exciting. And it's an explicit intent of the RFA's, especially the Common Disease RFA that's already been issued, that that happen. And as I talk about the coordinating center, I'll get more into that. So, I mean, I sort of envision this, that each sequencing center is going to have an important software component and an important analysis component, but it won't go all the way and that this coordinating center will be a tremendous value added because it'll cut across all of them and perhaps go further. So, we haven't gotten to the coordinating center yet, but I'll get to that. But the analysis center certainly could provide some muscle for that. That's what I meant. I meant the analysis and not the coordinating center. And I actually don't look at it as a clean divide, I think, as you're presenting it. I think that it will be overlapped. There will inevitably, there will be good people in every one of these funded components who are extremely interested and motivated to work on a problem. I didn't mean to suggest that it was a clean break. In fact, quite the opposite. They should be bleeding into each other. That's exactly it. And, Adam, can you clarify whether the, to get at Howard's point, that the applicant can't be the same PI on those grants, but it's not like individuals that have that expertise from those institutions can't apply, right? I, in this case, there are a couple of considerations. I'll just lay out the principles that I understood from the previous conversation and what I've brought here. We definitely don't want the PIs to also be of the CCDGs or the CMDs to also be PIs. We would, I think there's a principle here of independence, of intellectual independence, that's important, even though they're all going to be collaborating. And I think that there's a second principle because that results to the more creative science. And the second principle that I briefly alluded to was the issue of pushing things out from the sequencing centers. And to this extent, that a sequencing with CCDG is very strongly identified with an institution, there could be, it could become a factor is the way I'm thinking about it. But the question is whether to to draw really bright lines or to draw some bright lines and state principles and wait for funding decisions to do that. And that's what I'd like some council input on. How strong is the principle of pushing things out away compared to getting the best science and the other criteria of just intellectual independence? Well, I do think you should be clear on whether you're going to draw that line deeply in the sand or just etched because the people in the sequencing centers will have a competitive advantage. They have the data, they have familiarity, they're already doing a lot of this. So if we don't want them, if we want to push it out, then we should push it out. But if you draw that softly, it's going to be a hard thing to undertake at review. My sense is that a successful applicant for the large scale sequencing program will already highlight their internal computational capacity, what they're going to bring to the analysis table, and the point of this RFA is to bring in people that wouldn't otherwise be at the table. And I would also encourage going forward because, as we might imagine, this will change over time in terms of the way the analysis is going to actually happen to be open so that even if people aren't funded, they can participate. And there's a strong culture that already at NHGRI, again, I mentioned projects like thousand genomes, but even in ENCODE and ClinGen, we've got people who aren't funded investigators but want to participate and contribute. So I think there's a lot of ways of making that happen, but I personally would agree with Lon that if you want to push it out, then push it out. Push it out, okay. Yeah, Jay. So I don't know if this is the right place for this comment, but one of the things I liked in what was written here was this notion, and I think it's both in here in the coordinating center of these centers being tasked with deciding when a study is complete. Right? And just kind of stepping back, I think looking back at kind of ARO-funded studies and things like that, I think one thing that's been challenging in this era of exome or genome-based studies is getting negative results published. I think they're important to report and to understand the basis for failures and to, you know, lens insight into what we do in the future. But there's obviously not much incentive for people out there doing the studies to publish negative results. And I just wonder if this can kind of be expanded to include not just deciding when things are complete, but also ensuring that negative results get reported so we can learn from them. Yeah, happy to do that. And that's also would become, then, a task or item for attention for the coordinating center as well as I will present it. Yeah, but a similar comment was strongly made when the first two concepts were approved. But that has to be a feature of the program. Yes? Yeah, I agree that the rules have to be set up upfront because then people apply or don't apply to things and don't get into that situation in which they don't know what kind of collaboration it's expected with each other. I think that this needs to be formulated a little bit more crisply. There was some language in one of the slides about data that are not coming from the center that they could do that too. I think that's a little confusing too and perhaps not the point here to confuse because if it's part of a program to deal with data from that center, then that's what it is. And not additional data coming from elsewhere. So one of the things that we'd like these centers to do, the analysis satellites to do, is actually to be more outward looking, to have the luxury of being more creative and more outward looking than just the centers. So while we wouldn't accept an application that didn't propose to work on the data coming from the sequencing program, we would very much like to have proposals that are creative enough that they feel free to use to incorporate other kinds of data. For example, functional data and other types of data specifically to make, for example, the identification of associations better to be able to make functional inferences as a means to improve power. We don't know, we've heard over the last year and from within the program and other places about combining and see it going on, we see it even going on in projects already, where people are using functional information, for example, from the ENCODE project to help them make inferences about the variants that they'll find. And I think that there's a lot of room for creativity and advance in that kind of area. It wasn't meant to say, this is what you're going to focus on alone, this is the kind of data you are free to bring in to your analysis. I think my comment was just if they're supposed to collaborate and if there is a set of mandates for that collaboration, then that needs to be wasted against the creativity as well. I'd like to invite comments from people on the phone, Val or David. You want to jump in here? Good. Can you just briefly comment on the distinction between what the analysis centers are doing and kind of what's being set up in FUNVAR? Yeah, Lisa, are you here? FUNVAR. We've had some complaints that those remote mics aren't working. So FUNVAR, as you probably all know, is designed computational approaches to try to figure out actual causality, which variants are causing signals under peaks with experimental validation. And we realize causality is a really strong term. So the computational approaches don't necessarily have to prove causality, but we're sort of trying to get in that direction. So it's a specific type of issue that's being addressed by these. So we haven't made the awards yet. When we do, we'll have a little consortium that'll be meeting every month or two and in person once a year. So it's going to be, so in terms of the questions for this, I don't know how much, Adam, you meant for it to go into causality. I think it's possible that somebody could propose to do that. I mean, what we've been thinking of, because we have been getting the occasional other application outside of the FUNVAR RFA that is interested in causality. I mean, good, it's an important question. One of the points of doing an RFA is to stimulate interest in the field that we think is important. And so then we get these unsolicited R01s that are actually coming in with this area. So our feeling was that we would simply sweep in. Anybody who's doing that, we would just put it into the consortium because it's supposed to be a collaborative consortium where people exchange ideas. It's not any sort of special deal. Anybody who wants to talk about it is welcome to do that. So I think that if out of this particular RFA, there was stuff with causality, they'd be welcome to sort of be part of the FUNVAR discussion.  So I think the more research, the more groups that are working on this, the better. Does that answer the question? Other questions for Adam. David Page here. Go ahead. So just a point of information. So in this clearance and the next, there's some focus given to this question of defining when a project is complete. And I guess what wasn't clear to me is what action follows upon such a decision. And just to be, to make some light of it, I don't know that I've ever worked on a scientific project that was ever declared complete. But if you were to put such a focus on declaring a project complete, it implies that there's some action that's motivated by such a decision. So what would that action be? Right. So this was when the CCDG concept was presented, it was in there as well. And that is that we have an intuitive notion of when we're done finding all the variants that underlie a common disease. It seems simple to state, but if you think about different disorders, if you think about technological limits, if you think about how far you want to go with effect size or practically how many individuals you can sequence, where what you find is no longer making a difference, even if you could put in another 10 million dollars. This is a question that has an approximate solution. But as was stated in the workshop, I think Mike Banky said it in the workshop, we may have to go farther than we think in order to know what the right stopping point is. So it's also a research question, and it's something that can only be addressed in consideration of a number of designs, in consideration of a number of different disease or presumed disease architectures. So while we expect applicants to have an opinion about this when they apply, we also understand that our knowledge of it or reckoning of it will change based on scientific and practical considerations as the program produces data and analyzes it. So that's really all that was meant by it. It's not a definitive notion. It's an intuitive notion. Some people have already heard people propose very concrete ideas about what saturation in such a study means. And that's a possibility as well. Eric Borwinkel, do you? That I would give a very practical answer to the question, it's when NHGRI is no longer going to support it. Because it could be that the disease-oriented communities and ICs will pick it up and run with it because they have a different purpose in mind. It could be pharma would pick up those findings and run with them because they have a different purpose in mind. Right. So I would avoid saturation and talk about completeness in a very practical setting for the large-scale centers or these various programs. Because we've seen, many of us have seen and showed these kinds of curves, the more you sequence, you're going to find more and more variants, many more, and they'll be associated with disease unless we basically sequence a large enough sample, where indeed every base is variable. Which I don't think is on the table, at least right now. Ready for a vote? Can I have a motion to approve the concept? Second. All in favor? Any opposed? Any abstentions? David Val and Amy, why don't you just email your votes? Okay. All right. Okay. Phone folks, I think we're going to take a break now. Let's keep those caffeine receptors saturated. So go upstairs and be back about 3.10.


My name is David Karki, I'm with SDSU Extension and work as Agronomy Field Specialist. But for the last two years or so, I and my colleague, Amanda Bachman out of Peer Regional Center, are also co-co-ordinating SEER efforts in the state. Our first speaker will be Michelle Tian. So Michelle is a Ogallala Lakota woman from Percupine, South Dakota. And she's a landowner and great grandmother who owns Wicani West Resistance Farm. She's regenerating her land through agroforestry and permaculture practices, implemented after becoming a SEER grant recipient. She's focusing on food sovereignty by growing her own food and preserving her culture by reintroducing endangered native plants and medicine that were used by Lakota people for centuries. Michelle is helping the elders with similar land, elders with similar land grow food through demonstrations, social media, and sharing crops. So please invite Michelle, Tian for her presentation for next 10 minutes or so. We watched the resistance farm in Agroforestry and Permaculture Demonstration Farm. Welcome to Windy Hill, my residence. My grandmother was four years old when the DOS Act of 1887 was passed. The act opened up Lakota territories to the land rush of the 1890s. Our land diminished 90 million acres overnight and land was allotted to individuals. They were given land that was unsuitable for farming. Historically, the Lakota were not agriculturists. If you did not enroll on the DOS roles, you were not afforded any land or allowed being a member of the tribe or a US citizen. There were many problems with the DOS Act because of boarding schools, lack of farming experience, inheritance became too small, size of holdings also. Allotments were sold to non-natives and natives were underpaid. It was destructive to our cultural identity and sovereignty as many other anti-native acts of legislation. The climate is a challenge at Windy Hill. The climate made us look for another way of growing food.  My West Garden in 2012. My East Garden, we made tears. We grew foods we liked to eat. Steve picking weeds in the East Garden in 2012. I reached out to local resources for help before SAIR. We participated in SDSU Extensions, Native American Beginning Farmer Rancher Program 2016-17, SDSU Extension, Tribal Local Foods, Agrability Who Assist Disabled Farmers, we became participants. Oglala Lakota Tribes Vocational Rehabilitation, Who Assist Disabled People, we became clients and they enhanced us to become farmers. USDA NRCS Equip, we applied for a high tunnel and received it. Project objectives for the SAIR grant in 2019 were to identify techniques and strategies to reduce erosion control on sloped forested landscapes, identify cultivatable traditional Lakota plant foods that can be incorporated into a regenerative agroforestry permaculture farm, evaluate the effectiveness of permaculture agroforestry techniques and strategies on forested slopes, evaluate the effectiveness of using a drip irrigation system, sheet mulching and contoured beds and pathways, on forested slopes to improve the quality of the soil, lastly to share findings through videos, pictures, et cetera. The month of March in 2019, I got my grant that the bomb cyclone hit and we had five feet of snow. That's climate change. We collaborated with three member, a local nonprofit and SDSU Extension educators and volunteers that came at the beginning. The next year, the pandemic hit. Volunteers were leveling off the ground from my higher tunnel, clearing the way for low tunnels and pathway stairs. We began transplanting trees for windbreak, using permaculture strategies, techniques and conservation practices, transplanting plum trees and choked cherry trees from my dad's house. Economically, it was easier to transplant trees and to buy them. I did both. Here we are with pine trees, plums and choked cherries from my dad's yard. The organic matter is low and needs nitrogen. We have incorporated sheet mulching, compost and drip irrigation, making terraces for the choked cherries, buffalo berries and plums to reduce erosion and catch water runoff. We laid a drip system when we planted. At the end of summer, they have grown. The drip irrigation for berries when we first planted. Berries in the wind constantly blowing. Berries this year are getting tall. Berries in the fourth year. This year, the fruit trees produce some plums and choked cherries. Everything runs downhill. Dirt road from my house to the highway, making beds with use of pine trees and PVC pipe for low tunnels. Making steps before adding mulch and assembling our low tunnels. Using garden cloth to prevent weeds. The steps after they are done making pathways. Sheet mulching and composting to improve the quality of the soil and improve water holding capacity. Laying newspapers, collaboration with SDSU Extension educators. Here's Steve, my husband, watering the garden after planting onions. Protecting my crops from the climate. Everything grows faster when it's covered. Train for my Gothic high tunnel is finished. Plants and trees that need to be planted. The jalapenos and a mixture of plants that year. Aspen and ash. Drip irrigation line that we installed all over. Trees with the drip irrigation make some grow faster. Tree of life day became an annual day for my family. From the pandemic kit, we didn't have any more volunteers only family. Trees we planted were cottonwood, plum, silver, maple, quaking aspen, ash, apple, mulberry. We are planting cottonwood trees. My high tunnel has provided a lot of food for us at Windy Hill. I am able to finally share what I learned with everyone. Here are my vegetables and 21 bits of sweet grass in 2022. We have incorporated traditional native plants and I plan on expanding it next year. Here's some red twig dogwood. My elder berries, first year they produced fruit. My osher root, first year it went in the ground. Here's my tobacco. My blue cornfield. I save my blue corn seeds and each year I grow more. I dry them and take the kernels off the cob. This year I planted 375 and yielded about 275. I had cattle walking through my cornfield. Testing the soil and plots with soil testers. We had to add peat moss or bone meal besides the sheep mulching. In 2021, the pH balance is good. The soil test in 2017, the soil needed help. The sun going down in the west. Remembering our traditions includes growing our traditional native plants. Regenerating the land can be applied everywhere. My goal is for my family to be self-sufficient and to be able to help our elders do the same. Thank you for allowing me to share with you. Can you talk about importance of building relationships for these projects? Obviously I want to be able to finish my project or even start it without the help of community and the people that I had met on the Pine Ridge Indian Reservation of the Oglala Coat Nation. I was able to partner with SDSU immediately so they were a big help. There was other people and organizations that worked with us. Fortunately for me, I'm 65 years old, I had help and I would have been able to do it obviously all by myself so I was very fortunate to be able to work with young people and I'm really happy to see so many young people that are so interested in the ecosystem and saving it, regenerating it because without the ecosystem we can't grow food, we can't have meat, we can't be alive, we can't survive without water. So these are some of the things that I'm really happy to see all the young people come here for today and be involved with the ecosystem today and saving it. So thank you for letting me be here and working with all of you. What advice would you have for somebody who's interested in applying for a grant? I worked with Joan Benjamin, she was really great to work with and it's real important to keep in touch with them and ask them questions if you're not real sure about the grant. One of the good things about the grant is, which is huge is you're allowed help, you're allowed stipends to help, get help with from other people and that was huge for me at being an elder. So the most important thing for me was sharing everything with Sarah.


Today, we'll be addressing Kapitan Adryan's question. Does Google count nofollow links as backlinks? I'm seeing these links in the link report in Search Console, and I know for sure that they're nofollow. Hey, Kapitan. Thanks for asking. We've already talked about the general usage of the rel nofollow link attribute. When our systems run across links tagged like this, we take note of them, but we don't forward any of the so-called signals to the link pages. In general, this means we don't pass any page rank from the linked source to the link target. However, it's still a link on the web, and users may be using those to reach your website. And so in Search Console, we decided to show these as links, together with other links pointing to your site. Similarly, if you were to use the disavow links tool, those links would no longer be passing any signals, but would continue to appear in the links report in Search Console. In short, links with a rel nofollow don't pass any signals to your website, but they will still be shown in the Search Console links report. I hope you found this video useful and insightful. If there's something you want to add, or if this video has helped you, feel free to comment below. And don't forget to like our videos. And if you want to send us more questions, use the hashtag Ask Google Webmasters on Twitter.