Can you see? Can you see? Yes, we see and hear. That's wonderful. Perfect, okay. Good evening. It's almost three o'clock in the morning here in Singapore. Talking now, nice continuation from transcriptomics, skipping one step and then we end up with the metabolites. So, yeah, the package or the talk will be about small molecules. So small molecules, just a quick overview are made of course metabolites. Metabolites includes also the lipids and also includes signaling molecules and also becomes more and more relevant is the natural products for secondary metabolites from plants and microbiome. And then we also have the drugs that are measured also in the same approach often. And now we have, you see here up there, you see clinical measured in the first row there, you see clinically measured compounds here, especially focusing on lipids because our lab is working mostly on lipids. And we see here, for example, the total cholesterol, we see here the triglycerides. If you go to the doctor, he does a lipid panel, he will measure these two compounds and these are total compositions. But if we then look more in detail, these are the triglycerides that are measured in the common mass spectrometry platform. So we found around 30 or depending on the methods even up to 100 different triglycerides. And the same is also for the cholesterol. Cholesterol is a mix between astrified and non astrified cholesterol. And the question is, is the total cholesterol more gives you more value than the individual compounds or maybe a subset of the individual lipid species. So the clinical application or the translational research that has been done. It is Metrolomics and Dipidomics focuses basically screening for screenings for new biomarker, biomarker discovery. And then maybe ideally, in the future, we will have multi metabolite or analyte panels, like fuel or 10 to hundreds. And that maybe gives you a fingerprint of a health or disease status. And then what this omics or metabolomics studies also reveal is new diseases or mechanisms in health and those in diseases. So here you really see a map here of lipids are measured in one single mass background. And we can measure 500 pieces depending on the approach that this doesn't reflect by far the reality. So we measure a sum of compositions. And so in reality there's much more behind it. You can already see the complexity and that this may just a quick overview what is the mass spectrometry or how do we do that. So one keyword is here we try to reduce the complexity of the samples so we take plasma we extract the lipids get rid of some of the what soluble compounds. Then we make a chromatography we separate them depending on some properties and then it goes to mass spectrometry. Basically we have here to mass filters, which can select specific molecules with specific mass and they go into a jumper. And then we collide with nitrogen and then break into fragments here. And then the fragments are characteristics for the molecule that we want to measure, and we can measure the abundance of the accounts, and this will give us raw data from some here in the targeted approach MRM here gives us raw data in form of a chromatogram. And the big question is, or the big challenge is how to process such data and how to look at which peak is which one, and how to automatically fit this. And then from this step there's another step from this peak areas is the calculation of concentrations. And this is exactly the part where I'm talking about this is from the process through the raw data to intermediate data that still needs to be like peak areas that has to be further processed. And just give you an overview about our lab or about how we work and what are our challenges. So we are situated in a university but also closely work together with the hospitals in Singapore and around the world. We measure cohorts sample cohorts clinical trials model studies and also mice models and sometimes even plans and and virus samples and like this. So we have a big diversity in projects. Also, and that also is reflected down in the scales. So we measure between four we have panels, we only measure for specific lipids but we also have panels where we can quantify around 600 lipids and this for various more studies like ready patient consider a disease and we try to do some work, five samples but nowadays we have cohorts that reach sorry it's one zero too much here but maybe that's the real future what I wrote here. So, currently we have core cohorts that go to 5000 or 10,000 or even actually close to 30,000 50,000. And we have various tissues, mostly plasma, and we use different methods we have established methods we have new methods that are on the development where we maybe still try to apply them to some studies. And we are trying to implement publish or novel methods completely new from the scratch. So different platforms, and the same is also different analytical platforms that different the way the data looks like, and we also have tools, different tools open source and the vendor specific tools to process the data to do exploratory data and then for data processing that we'll talk about is a big diversity in the lab, Excel are some shiny apps that we have developed. And now coming a little bit to the challenges from our lab. So, we have many people, but we also have a lot of lab is called incubator because you also have a host many visitors and students. And that gives a huge or quite a big diversity in terms of scope from biologists to really analytic chemist that we have background experience. And what we more and more see is that especially because the number of data bioinformaticians and statisticians in our group is relatively small. What we see here is the communication between the biologists biochemist, the analyst, those who really do the work in the lab and really see what the instrument is doing the bioinformaticians, and then the statisticians this communication and the workflow and how we deal with this is becomes more and more of a challenge. And this challenge reflects down in data quality in the reproducibility and the consistency. But also, what especially is lacking in the data is passed from an analyst to be a bioinformatician and there's almost no communication between them. We basically often miss the chance to learn from the data, like something goes wrong with the analyzers or something looks a bit weird. Of course, we can apply batch and drift corrections or this is fine. But maybe if we really look carefully at the data we can maybe we will be able to see artifacts or system issues, or she process problems that we can improve when there is a constant feedback. There's also the issue that many analysts and biochemists, they produce their data, because the large amount of the data, the complexity, like 100,000 or million of data points, they really are dependent on having someone who analyzed the data. And then it starts again, the communication and can you do this block for me, can you look at that. So, and then so what we were asking is how can we improve this process. And strategies are of course we could develop software tools shiny apps that people can use upload their data they get something back. That's one possibility, but this has limits. Especially due to diversity of projects. Some people might have a special case or they wanted this plot and suddenly fixed program tool shine up will not be able to do this and then the workaround is often go back either to excel or really to from scratch start with data license to analyze those specific cases. Well, so we are trying now to train people biochemists students, a little bit with our, but, and this is on the right side we have here from a conference workshop that I organized together with him one joy. And we really go through a published paper and really analyze the data without actually any external packages just to be tidy words mostly and then the statistical part to standard standard protocol standard packages. We really try to go through the people from really peak areas to the final results of the publication. We realize these workshops when we sit together with our people in the lab, we see that there's limits to this. So you, because they are just not able to really catch up with learning are beside the normal work and then they maybe will have one month no time to look at our data and come back. It starts again the procedure. So the idea is a little bit to create a package now that helps me by my colleagues by additional colleagues and colleagues in the lab to analyze data, like a common platform where we can handle the data share the data, and that can be easily enhanced and improved for us. And so this is now online at the moment, but I have to say that it's still not ready for production, but it's amazing online for sharing and for having some feedback. And the idea of this package is to to collect data and manage metadata, especially the metadata is quite complex. So we capture this, the internal version of this package will be able to access our lab information system. So we can directly retrieve sample associated metadata that explains on the analytical side but also on the subject side directly from the limbs. It will be flexible in the way that we can analyze the data so we can apply different batch corrections or normalization strategies and filtering, but we want that these are not applied in the black box approach. So we want really to see what happens when I do a batch correction, but that's the data really look better. This can actually happen. I mean, if we use normalization with internal standards to the, how does it look like, and we want it to be traceable. And then this package should help us also in reporting and sharing of the data, but not just the data itself. As I said, also to record the process, the process to the data, and that this is not just in a, you know, in a notebook somewhere in our notebook, but that this is actually part of the data file that can be shared. And this library then will be used for people in the lab by buying from additions from us and also then serves as a base and more of a space for maybe possible shiny apps or other applications that we use. So in this row actually I prepared a quarter reveal JS presentation, but at the final moment still didn't really work to go online but I have a PDF here. And so we need our and it creates an object that is a S4 so it's a little bit like by a conductor package and we can, but unlike most most packages that exist for this similar field. So most of this package are not really focusing on the real preprocessing of data, especially handling a lot of metadata and really offering this flexibility. So we have here on S4 class where we can, for example, import direct raw outputs from the instruments computers. So there's no manual reformatting needed. That's what really important for us that in case we have to go back to the instrument we can just explore it again and reanalyze it. And then we also can import metadata, metadata can be plain text files but having integrity of metadata so that they really match to the data it's a surprisingly massive challenge. So we have two systems we have the limbs start to use the limbs more and more for certain things as a kind of a lab notebook, and then also a colleague of me, former colleagues made an Excel template macro based to really help people annotate the data based on the notes and in Excel or even in the notebook to really make consistent and data that are keep the integrity. And then we quickly look at the print method of this object we will have no fuel what what is the important and not and unfortunately cut off here but below we also have an overview of which processing steps have been applied. And then we can continue with this object and then we can apply for example normalization with internal standards which are like deteriorated or heavy labeled standards that we spike in at the sample as early as possible. So we normalize them with quantity based on the amount that we know of internal standard and maybe sample amounts protein amounts. It will give me if you give us immediately the unit, but that's always a surprise always again a surprising thing that often the unit with so much concentration calculations is a little bit confusing for people. And then we can calculate QC metrics that will then and this will allow us then to filter the future that we measure which repeats in this case, based on analytical CV, for example, I can set the threshold of 20% CV here signal to blank ratio and the linearity of the measurements to dilution or response curves. And then here it will gives you back in an idea and so that every step should, if you have back an idea what happened to your data so that you're not blindly following something. And here we see that 400 measures futures that we end up in 95 futures so only 25% that's not good. So we can now do a batch correction. So first we correct for drifts. So we have the option to do a drift corrections there's will be a different algorithms there. And also here we'll give you an summary also it will warn you of any issues that you might follow up. To do a batch correction and then we filter again and now we see we have recalled three hundred thirty three species. So, in a quite short time that usually when this is done in Excel it's only possible to a certain stage, and if it's done by scripts by buying politicians, it still has to go again through the processes. So it can really be done by the people itself in the lab and is also being done now. So they have enough knowledge about our studio to run such simple things through, but still kind of black box we have three hundred spaces but we don't know really how it looks like so big focus on this package is also on really creating plots. And so there's a function to really play quality control plots that help us to understand what is in the plots. And this is now an example here so you can put some intensity over the runtime. And you see here, there's 200 samples and you see the different QC types and different colors in the yellow bar on top there. That's a way to cap as samples that are too high and would skew the whole plot so that we basically can focus on the most important thing which is the QC analysis and look for some drifts and indeed we see here this is uncorrected data. We see here really some batch effects here that happened in the first in the second and the third batch. With these plots, if I use Quarto presentation, you can actually scroll through very nicely on the same page with scrollbars. So here we have it on different pages and you can also be exported as a PDF. And we also also working on a shiny up to visualize this in an efficient way, which is still quite a challenge, but making some progress also there. And then we are now. So the idea is also that you can use these objects that are plots, for example, the ggplot objects that you can use them for your own things and customize it so you have a base you have the data you need. But you can continue to do your own annotations of the plots, make them ready for publication, or maybe do some own analyzes for your specific case and here we see here the batch correction before and after batch correction here. You can plot it two times and store it in a variable. And then you can just continue this and not possible here because it's not inductive PDF but you can just add this variable to a ggplotly function and you already get an active plot and you can see which samples are maybe you outliers. And then as a final stage is the writing of a report. So there's different options. One is the Excel report this is in the moment active there's also a PowerPoint version because at the end PowerPoint is still acceptable by many people and can easily be shared with a little bit QC plots and everything but here is the Excel sheet which contains different sheets. One is an information sheet that contains information who has analyzed the data when which package version and all the QC parameters that have been applied or QC steps. And then you see the different QC metrics and then the final data sets that can then be used by internal groups and then we share with others. And then as a second thing you can actually save this as for object as a serialized file, and then you can actually send it to someone else you can open it even without the package as possible to open it you see the different data sets. You still have to be working a little bit but they're quite readable, and then you can actually continue with midar to process and to expect the data. So, and since all the information is stored from metadata to data and all the processing steps are recorded, basically have a fully reproducible workflow stored in one data object file. The next step is really to make it work on it and maybe get some user feedback and to implement that plots that we use in the lab and function of using the lab at the moment to export them to the public version. And then shine up is also on the development time gives. Yeah, so we'll stop here with a quick thanks to our lab that is headed by Professor Marcus wing and my colleagues who constantly help each other to optimize this work source in the lab. And also a big thank you to the great conference. It's my first time I attended this conference. It's really an amazing conference. Thank you very much. And yeah, open for any questions. Thank you Dr Burla if you have any questions please drop them into the chat. I particularly love that in these in this kind of talk that you began with like giving us the details of the science about what we're about to do as someone who doesn't work with the state of very often I appreciated that a lot. And I also love that at the end you get an encapsulated object with the entire workflow in the process, you know, being outlined there I think that's fantastic. Yeah. I really like to have feedback on this and it's a big endeavor. All right, we have a question from Luca do you plan on an extension to untargeted metabolomics. I'm not great at pronouncing words I've never said out loud before. Yes. So this for me. Yeah, yeah, yeah, sure. We also do untargeted lipidomics or metabolomics. And we, yeah, we especially focus a little bit on ensuring that the, yeah, the idea of lipid or the metabolite identification and annotation is correct. Yeah, definitely. And glad to to to the data sets. Our lab is also working on this. That is fantastic and we have some other nice comments in the chat about the package people have used it. So, again, thank you very much, Dr Berlin I hope you can get some rest. It's pretty early.


One of the most exciting and newer procedures that we do for breast cancer care is a nipple sparing mastectomy. We can make a small incision that's underneath the breast and remove the entire breast while preserving all of the skin and preserving the nipple as well. Once the breast is removed, our plastic surgeons are able to come in and do a reconstruction through that same incision, whether it's an implant based reconstruction or a tissue based reconstruction where they're moving the patient's own tissues around. And it really gives us an opportunity to provide the same cancer care and do a really excellent mastectomy while preserving the patient's natural features. The reconstruction can recreate the contour and the symmetry and a lot of patients have been very happy with their results.


No, no, no, no, no, no, no. I'm off this week. Okay, so you're gonna see us revise a lot of our GPS products. The GPS module, the ultimate GPS module we've been carrying for like a decade, no longer being manufactured, but we found a drop in replacement that is a little bit taller, it's four millimeters tall instead of like two or three millimeters tall. However, it's pin compatible and so we were able to drop it onto our devices. The only thing that's a little different is it's a GPS plus Golognas. It's like it uses, it can also receive the Russian GPS system. So that might be good. You have a lot more options for satellites to get data from. That's still very fast, very low power, up to 10 hertz update rate. A couple of the commands that you use to detect the antenna change slightly, but it's all in the data sheet and this is a great drop in replacement. So thankfully we're having all those GPS units, all those GPS products that we're getting out of stock they'll be coming back into stock with this new version. Next up. You have a Trinki, but you want to use it with your latest MacBook, where we've got a USB-C to type A converter. It's great for anything that uses type A USB, you want to type USB-C. Like a light up Adafruit key. But it's great for Trinki, so you can just slip on the end, plug it in and you're good to go. Next up. Okay, we also have a couple of new key packs. So this is a pack of 12 Kale red linear keys. This goes with the macro pad kit. So we got them in a pack of 12, so it's very easy. You don't have to worry about like two packs of 10 or whatever. You get a full 12, so you're good to go. We also have singles of Kale black linear and Kale blue clicky. So... I think I put both of these together.  And then the blues are clickies, but they are sold in singles. We're gonna try to have 10 pack in singles so that way you can get just the number you want. Or if you have a Neo key, you don't want, a whole 10 pack, you just want one. So we'll also get singles of the reds and the whites eventually. Then we have these. We also have, these are the clear translucent DSA key caps. We stocked these in packs of 10, but now we also have them packs of 12. Why to go with the Neo key, sorry, the macro pad kit that's a 12 key macro pad. So you can still get these in packs of 10, but if you're like, I need 12 and I don't want two packs of 10, this 12 pack is ready to go. Nice symmetric, translucent, clear DSE key caps. Feel great and snap onto any Cherry MX compatible switch. And stars of the show tonight besides you, Lady Eda, our customers, our community, our staff, is the macro pad, first up, the bare bones one. Bare bones, why are we stocking the bare bones kit? Well, there's a lot of people who are in the keyboard community and they just want the bare PCB because they want to add their own key switches. They want their own rotary encoder knobs. They want their own enclosures. No problem, we got you, we got you. This is just the bare bones macro pad PCB. It's fully assembled and there's no soldering required. It's got, it's a macro pad. So it's got 12 mechanical keys that you can plug into those slots. They're Kale sockets or compatibles. Each one has a Neo pixel that goes underneath. You can blow through the key. On the back, you've got the RP2040 from Raspberry Pi. It's a great little chip which we can run Arduino or circuit Python on. Eight megabytes of flash that go with it. Each key is connected to an individual GPIO so you don't have to do any matrix driving. It's just like one key per. We also have a 128 by 64 monochrome OLED which I think is just super fun if you want to display what you're typing or have some feedback or overlay details. There's also a rotary encoder that we solder in. It's a detenti rotary encoder. It's just like 20 detents per revolution and there's a push button, push button in. There's also on the back a little speaker. So the speaker is eight millimeters. It's not like a high resolution speaker but it's good for like little beeps or sound effects or tones or audio feedback. So you want to know when you type something it'll maybe say what you typed or give you a sound effect. I will mention that at the time of this video QMK does not support the RP2040 chip itself. And so if you're like, I need to use QMK. You can't at this time. One day QMK will probably support the RP2040. What it does, we'll provide some firmware definition for it but right now this is for Arduino and circuit Python use only. Okay, next up we have a kit that comes with a little bit more. This is the add-on pack. So you've got the basics, right? And so you've got the, you could also get the 12 pack of keys that we talked about. You can get the 12 pack of translucent key caps but maybe you want like a little enclosure type thing. So this is two PCBs and a little bit of hardware that you can add on to your macro pad to kind of make it more fully ready to go. So there's like, this is what we call the enclosure or the mechanical part. So there's two PCBs. One of them is a mechanical key plate. That's the part that has all the holes cut out. So that, it doesn't have any mounting holes but what it does is when you snap in the keys they kind of all hold each other in place and it keeps them really nice and solid. It works very well. It's a stableizer plate for just 12 keys. And then you've also got this really beautiful bottom plate that's designed by Phil B with like a cool like NASA space theme, like Vera Rubin quote. Got some sort of like Voyager probe type thing going on there, space planet. We're going with space theme for the macro pad.  It also comes with four bumpers. So to protect your desk, the four screws to attach the bottom plate and then a rotary encoder knob. So this is the add on mechanical kit. Okay, and here it is. Okay, but let's say you're like I too complicated. I don't want to get separate keys and key switches and key caps and whatever. I want the whole thing, we get the starter kit.  So you get the whole thing. You can make your very own three by four OLED and rotary encoder macro pad. We looked at a lot of macro pads. They're all really awesome, they're great. We just wanted something that was kind of like a little bit of everything. You've got a smidgen of rotary encoder. You've got a smattering of keys. You've got an OLED display, USB-C RP2040 chip controlled. So it's got kind of a little bit of everything but it's really easy to reprogram in Arduino or CircuitPython which is what we're supporting with this. And I think it'll be neat, you can use this. CircuitPython has great MIDI support. It's got keyboard support, it's got mouse support. You can use our new faster key scanning core in CircuitPython 7 to make your own macro pad. And of course the OLED display. You can use that as feedback to display what the keys are, what they do or if you have an overlay or functionality or you just want to have BongoCat going, go to town. So this is our first like macro pad keyboard thing. We've been doing keyboard projects using individual keys but now we've got something all in one that's no solder that's ready to go. So I'm very psyched about this macro pad. Maybe I'll show it on the overhead real fast to wrap up the show. Okay, so this is really close. So this is the 128 by 64 monochrome OLED. And you can see here, I've got the rotary encoder. You can detect when it's pressed as well. And then over here, each key has a north-facing neopixel. There's a lot of debate. Should we do north or south-facing? Well, north-facing one, hold on. And then each key here can be detected individually. You can press as many or as little as you want. It's very fast. The OLED is SPI, so it updates very quickly. Each key is individually connected to a GPIO. So you don't have to do any scanning. You can just quickly check if it's held down. And then rotary encoder add-on. And then altogether, it's a very beautiful silk screen on the back, thanks to Phil B. And this was your quote for Ruben. You suggested it? Yeah, and someone said in the chat the Ruben Observatory is starting to open and do some works in, so it's very on time. Yeah, and you got this really cool, like, cool, because this is just decorative. The bottom plate is a mechanical, but we didn't want to go with acrylic. We wanted something a little more sturdy, so we did FR4, and this shows you how it's put together. So there's the bottom plate, the standoff that's built into the macro pad, and then this is the mechanical support plate that keeps all the keys nice and sturdy. So there you go. We've got our very own keyb. Let's get right into it.


This study found that applying pseudomonas strains in our bustular micro-rise of fungi, AMF, along with lower rates of phosphate fertilizer improved the quality of strawberries grown on a calcareous soil, while higher rates of phosphate decreased antioxidant capacity. The results suggest that rhizospheric microorganisms can improve fruit quality in sustainable agriculture. This article was authored by Mohammed Hossein Ansari, David Hashma Badi, Maryam Madhavi, and others.


Hey, what's up everybody? So in this video, I'm just going to kind of walk through this new project that Unreal Engine team has put out a couple of their developers used Unreal Engine 5 to create this simple example game called Stacko Bot where you are a robot or multiple robots and you can go around and interact with various things and walk through the world and it's a good example of doing the world partitioning and loading in individual level pieces as blueprints It's got a lot of interesting stuff. So let's check it out.  They've got some interactions A little place where you can generate these robots some different things. It'll happen sliding doors moving panels Some little things to collect And then this pretty nice little background that they've got going on here some movement in these trees So anyway, let's just jump right into some things. I think it's pretty cool about this So first off the when you first started up, it's focused on this, you know, this map uses the world partition and this is a new thing in Unreal Engine 5 and They just have four partitions Created here. You could make as many as you wanted to out of this I imagine and the idea behind this is that each one of these is an individual level that is dynamically loaded As you enter the area and I believe that you can set You know the distance how far away from the area until it starts to load or whatever else You know, you can for the for the game purposes. I'll just go ahead and let's see. I'll just select all of these You see I can load these cells. I can unload all of them. I can move the camera to a specific Part I mean, let's see if I do this It's not loaded. So let's load this and Maybe let's load that You know what? Let's just Let's load them all We're gonna see what's happened. It's moved me to a point that I'm behind a rock Okay, so it it did work. It just moved me to a point in the map that that wasn't visible So at any rate with all of this loaded you can see they've built out some Some pretty neat things here. Each one of these buildings is a separate Level blueprint. I'll get into that here in a second. Actually, I think I've got it right here in the bottom Each one of these main areas is a different structure and so what they've got here is they've put these pieces together as a blueprint See, let's move this over They've built this out of individual pieces individual static meshes and they've just kind of combined it all into one easy to to place and manipulate Piece of code or piece of asset here, so They build all of this stuff in and this you know You can do different things in the event graph if you wanted to here You can have blinking lights or you could have whatever else that you wanted to and it's all contained within this one file And then if you have multiple Developers that are working on one level that each can have their own copy of this packed instance level here And that way they can You know make their changes Commit them to source control and not you know risk overriding or running into issues with other developers work it used to be in Versions before this that you had to basically check out the entire level and if you made any changes to it You had to then save You know push the level back up to your source control system have another developer pull that down You know and then make whatever changes and so this at least breaks it into you know Four distinct sections that a developer could work on and then you know individually load in You know commit back to the source control so that the other developers could could pull that that new work down and updated in their own project So way easier of a workflow when you have multiple developers working on a single level So let's see another thing that was interesting that I saw in the the overview made by the guys That created this is if you notice these trees back in the back. They aren't moving They're just like static meshes but then this tree has a little bit of wind motion to it and This is actually two different materials that they're changing based upon the LOD Oh, and how how close you are to it on the level of detail and so when you're close to it it will Show you one material and when you're further away, I'll show you another one. So I just got the I got to the distance there where this one is going to start and you can see it start to build in Dynamically load some some pieces here And this is interesting too, I haven't quite seen how they do this yet how they put this boundary up around the edge I imagine it's probably fairly simple to do since I think that's probably built into the engine The way that they fit all of this and everything and under one gigabyte is pretty interesting and that it works with You know PC or Mac I'm not sure if it's set up for mobile or not probably not but But at least, you know, you have some sample code that is at least cross platform So let's see. Let's just jump right in. Let's play this game for a second. That was a pretty neat little thing that little loading Thing that happens whenever you start to level let's do that again That little thing was neat and I saw where they did that was Let's see It was on the HUD I believe so let's go into the blue blueprints framework and let's look for the in-game HUD here Yeah, this is where they were doing this. So on begin play they have a sequence and the first thing they're doing is they're loading that little widget and Then they're just you know doing this set fade to fade to zero This is another interesting thing where they are dynamically changing the camera based upon Where you where it is in relation to the character like I'll show an example of that like as you get It's just handling, you know, this these Going into going through objects or whatever else or whenever you Go into whenever you jump or double jump and it goes into this Jetpack mode it zooms back a little bit just to kind of give you a little more Space on that. It's kind of jumping around. I am trying to play this game And also record and stream all at the same time. So not really sure how well this is going to go Has these little checkpoints like this and so as you hit this it Saving your game and it also makes that the next print Station so see if I hit F here to print a robot. It's gonna print a new one right there So this is another cool new feature of Unreal Engine 5 that they use in this example, and this is input mapping so normally you would go to your project settings and you would go to your Input section here and you would create all of your mappings right here This is how you would normally do this. I think you relate to these mappings, you know in your player controller or in your Your player blueprint whichever way this works now with this new input mapping scheme and so We have this new file that defines all of those same things that you would normally put in the input section So you have your your action here that you want and you have each of your keys here That you might want to to use for that and you can add as many of these as you like just like the other way This gives you a little more flexibility and that it breaks it out of your project settings Each one of those correlates to one of these input actions So you create one of these for each one of your input actions that you want to support And you know, this is like this one has a you know a 1d axis This one the jump, you know, it's just a boolean on or off So There's probably more flexible things that you can do with this in the future This is just kind of what I know about it right now and it was really neat to see them use it in this project I'm excited to learn more about this feature So this project is one of the first ones I've seen that has used the metasounds. Um, this is Very intriguing to me as a musician and into Sound synthesis waveforms and whatnot. That's kind of what you're doing here on these metasounds. So All of the music for this Example game is created dynamically using waveforms and LFOs right here within metasounds And the really interesting thing to me is that you can have input To to the metasound in this case, it's the bpm And so you can speed up or slow down the music So if you have a more exciting scene and you want to speed the music up To kind of add to the tension you can do that if you have a more relaxing Section and you want to slow the music down to kind of convey that You can easily just set the input of a bpm and that's a pretty pretty interesting way to do it So that you don't have to have multiple audio files that you were loading in To memory and you know switching over to This all looks fairly complicated. I haven't gotten into this very much yet, but it looks like we have a bunch of You know triggers that are waveforms that are being triggered By different things different bpm's. Let's see. We've got a LFO here. So this is doing some modulation on it Looks like we're kind of grabbing some random notes And we're doing a MIDI note quantizer so that we're basically sticking them into a scale So that they You know sound like like you mean for them to sound and not just random notes Yeah, so we're going on through this here's a couple of saw waveforms that they're adding in So it looks like they're probably doing some processing Of the actual MIDI note before it actually gets to the waveform generator. This is all really really cool I'll probably will be doing another video just on metasounds in the near future Kind of digging into what some of these new things do and how to add this into your game So thanks for watching Make sure that you download this demo and check it out It's got a lot of great stuff in it for Unreal Engine 5 things that I haven't seen tutorials on just yet And it gives me a lot of ideas for new tutorials to make And new examples that I can create with some of this stuff So, uh, you know, I'll leave links in the description of where to get it It's in the Unreal marketplace and I'll leave a link to the example Video that was created by the developers of this they go into some of these things In in more detail than what I've gone into here. Uh, and Anyway, it's interesting to watch. So thanks for watching and make sure you subscribe if you like this type of stuff


78% of the central bank are studying the digital fair currency, central bank digital currency, and I think the work from IMF, from Bank of Canada, from half a dozen central bank around the world in the working group with the focus group proves that we have created a great information for the central banks as well as ITU members to share. The objective from the beginning was to really look at the architecture, regulatory guidelines and the security for digital fiat currency. The focus group has three working groups and the first one is compliance, regulatory compliance and economic impact. The second one is architecture and the third one is security. Some central banks are looking at because they have a decline in cash usage in their country other looking at it because they want to have a more effective means of settlement. They may be considering to have a tool to foster financial inclusion or in some instances they are looking at it from a monetary policy perspective to have a new tool to implement their monetary policy. I think the most compelling case is for the inclusion aspect. Some degree of interoperability is required I think for that future world. So why not now build towards that future by building standardization into central bank digital currencies so that when you move up beyond the domestic only CBDC that you are ready to interoperate with other countries. The technology really can be a very strong unifying force not only in bringing the central banks together but also in terms of creating a basis for a whole new set of regulations. Everything is being digitized right? Of course from music movies anything that can be digitized is being digitized money is one of those and standards allow comfort first of all. Of course they allow a competition to enter the field and compete on equal footing. Money should go similar from one country to other moving around. So in that sense you need to have standards to make this possible without any big costs on doing that. So I think that there is a huge place to ITU to help this kind of standardization if eventually this technology is going to be marketable. There may be multiple motivations for a central bank to look at this and it's fair to say there is not a uniform tribe for this. We are planning to establish a future of currency lab where most of the member will participate so that all the solutions can be compared and evaluated and then provided to central banks around the world so that they don't have to chase all kinds of solutions when this. So we want to make this a clearinghouse for the technology for digital currency.


Hi everyone, Sean with jaspyscasebreaks.com here doing 2019-2020 upper deck stature hockey three box bake Random team number two where each spot gets you two random teams. So some Background on the break itself three box break 15 spots two random teams each one combo spot between the sabers and the capitals Each box contains one autograph one autograph patch card and one base set rookie card all cards ship in here So and here is our list of customers from Steve down to Oliver So since everybody gets two spots, we're gonna control a copy this list And double it up So you see Oliver Soria with last spot mojo there with the asterisks next to his name Scroll back up Steve Birch first spots purchased and then Oliver Soria again with last spot mojo back up to Steve and Our teams from the ducks. Here's the combo spot between the sabers and the capitals All the way down to the Jets. There's where the capitals would be so now there's only 30 teams or 30 spots and dice roll to Randomize both lists and pair them together six and a four and 10th and final time from Johnny down to Steve and 10 times on the teams and 10th and final time from the predators down to the blue jackets So let's make this a little bit easier for everybody to read So Johnny Ho with the predators Peter Aang with the avalanche Randall nest with the blues Peter Aang with the red wings Scott Corwin with the ducks and the Jets Oliver Soria with the canadiens and the islanders Scott Corwin with the sharks Ryan Steinberg with the senators Randall nest with the flames Michael Abazia with the kings Frank Lupo with the devils Steve birch with the coyotes Randall nest with the lightning Ryan Cason with the stars Scott Corwin with the oilers Johnny Ho with the Rangers Scott Corwin with the wild Ryan Cason with the penguins Steve birch with the flyers Thomas R with the panthers and the sabers capitals combo spot Scott Corwin with the Bruins Ryan Steinberg with the knights Randall nest with the hurricanes Frank Lupo with the maple leaf Uh, Steve birch with the blackhawks Michael Abazia with the canucks and Steve birch with the call Columbus blue jackets So that is the results let's Sort this by team name and open up a trade window for you guys So here's your guys's opportunity to potentially trade what teams you ended up with for other teams if you'd like So there's the full list While you guys are doing that i'm gonna open up the knit cam real quick So before we do the break You can see we have nine boxes here to show from the one case So one on the left One two three four five six seven eight and nine So we have to figure out what three boxes we're gonna do so I'm gonna click back over here and you can see the nine boxes still here on the knit cam So we're gonna kick over here to random.org home And we're gonna go to random number generator one out of nine First box we're gonna do Box six which is right here. So i'm gonna flip that up Six again. So obviously we're already doing that one two eight I mean I don't know about rookies all over but obviously old timers You got a guy named wing greski that played for them for a little while maybe So those are the boxes we're going to be doing Just so you guys can see one two three four five six seven eight and nine back there So those are our three boxes the other ones will be For the next two three box breaks that are going to be in the store later on So i'm going to throw those back over there and go back over to the trade window What's up adam? How are you? So any trades any talk of trades? That is it might be pretty good michael obviously depends on if the boxes Play in but Doesn't look like it. No talk of trades So we'll go ahead and print and rip. So here's the final list All of our last spot mojo canadians and the islanders You're gonna go dn with two. I want to go ol ol One and two But I don't know adam if we'll end up high enough in the draft To get the lineman that we want or need So I was saying let's use our third Plus whatever early first round pick we end up with To move up to spot two maybe spot three So I think ingram's fine But I also I also want us to I'd like to see us move ucena uosu full-time to dnd That's a whole nother story Oh a hundred percent a hundred percent But we'll see next year We'll be coming up Kapo kako 91 out of 99 Going to the new york rangers And johnny ho he's actually a very good rookie figure Steve yizerman century momentous For the detroit redwings peter ang These cards are awesome looking sydney crossby base For the pitchburg penguins ryan kason matt dumba minnesota wild scott corwin I agree adam I agree connor bunnaman rookie 293 out of 399 That's for the philadelphia flyers steve birch And auto koi vula 60 out of 149 for the new york islanders and oliver soria last bot mojo trevor moore rookie reliance 14 out of 45 toronto maple leaves frank lupo and auto mckinsey mitch mack etrin mckiteran rookie reliance For the st louis blues randall ness mckinsey mckiteran There you go randall There's a rookie auto for you cool first up dominant kubalik 15 out of 75 rookie for the chicago blackhawks steve birch eric bronstrom rookie reliance autoist senators ryan steinberg seth jones columbus bluejackets steve birch john marino to 399 Going to the penguins ryan casin patrick waw to 149 Montreal canadiens oliver soria last bot mojo like i said these cards are incredible looking gaton haas rookie for the edmonton oilers scott corwin to 149 thomas shabbat 11 out of 75 autoist senators ryan steinberg ilia macaef rookie reliance auto five out of 49 toronto maple leafs frank lupo and box three dante fabro i don't know what's going on on the surface there but nice rookie reliance 19 out of 20 you can see i'm not going to try to get whatever that is off hopefully it's just on the surface not scratching or whatever but national predators johnny ho fabro good rookie curvy dock another good rookie chicago blackhawk steve birch carry price for the montreal canadiens oliver soria joel furabi to 399 for the flyers steve birch dante fabro green 145 out of 149 predators johnny ho again too good goalies oliver don't forget phil kesel 23 out of 85 this man loves hot dogs arizona coyote steve birch he's one of my idols him and yama yager we got two autos first one cody glass 57 out of 85 for the vegas gold knights ryan steinberg that's a nice rookie auto there our second auto and final hit carl grunstrom rookie auto for the la kings number 2199 los angeles kings michael abazia there you go michael nice rookie auto there to end it and nice box to finish it guys that was 2019 2020 upper deck stature hockey three box break random team number two i'm shan jaspyscasebreaks.com random team three and four from the same case will be in the stores later on jaspyscasebreaks.com check it out thanks for hanging out and i'll see you next time


Metallic biomaterials have been developed as a way to replace or repair damaged bone and soft tissue. These materials can be used in joint replacements, dental implants, orthopedic fixations, and stents. However, these materials often cause complications such as inflammation, mechanical instability, necrosis, and infection. To address these issues, researchers have developed various methods to modify the surfaces and bulk of metallic biomaterials. Surface modifications include coating with hydroxyapatite, titanium dioxide, and polyethylene glycol, while bulk modifications include porous structures, nanostructures, and additive manufacturing. These modifications aim to increase biocompatibility, mechanical strength, and flexibility of metallic biomaterials. Additionally, researchers are exploring new ways to use 3D printing technology to create customized metallic biomaterials. This article was authored by Karthika Prasad, Ulbazaka, Mingchua, and others.


Bradford City goal kick inside the final minute of normal time in his first half. Cook goes up for it, flicked on into the path of Smith. Smith now, left edge of the penalty area. Get a shot in there at all of the season, and he goes the way of him to share here in the Sunshine at Valley Parade. Smith broke through on the left-hand side from the cook flick on. He drove the ball towards the goalkeeper who spilled it and just following up for about three yards out was a draw, who nodded down into an empty net. Parity restored on the stroke of half-time.


Everybody forced here. We're running the 2023 national promo I'm gonna go over the prizes quickly here. Oh, hang on. I had it up. There we go. Okay, so we did breaks from What was it Tuesday? July 25th through Tuesday July 1st of eight total days of breaks some breaks The spots were more more than one entry per spot just depending on price and we rip in Things of that nature. So I'm gonna screen share here and show you guys The promo again and go over some of the prizes here. I'm literally just gonna read his word for word. I think I'm not word for word. You can win more than once of course. That's just the point of purchasing more spots Anything with national break in the title was it it was very easy to find it had our little latent home with a boom Wrigley field sign logo on there This also includes the breaks that rich and I did on our channel to on the fly from the national So those are also included in this of course No prizes are transferable or refundable prizes cannot be traded in with someone else or traded for a different prize If you cannot participate or accept the prize you win it will be forfeited Grand prize is a bowman chrome Mike Trout's for his first bowman auto 9 5 10 Beckett graded there Second prize a ps8 86 Flier Jordan third-grand prize is a Bucks Pat's Tom Brady authentic signed helmet. It's very cool. And then the rest down here Fourth is a VIP swag bag, which has gold packs silver packs gems box and father's day packs the fifth prize is a case of Don Russ UFC hobby 6 through 10 spot 6 through 10 You're gonna get 10 silver packs and 10 father's day packs 11 through 20 You're gonna get 10 father's day packs 21 to 30. You're gonna get a hundred dollars in break credit 31 to 50 you're gonna get a blaster box of prism wwe a blaster box of prism UFC and a father's day pack Those are both 2023 products, of course as it says there 51 through 100 is $50 in break credit and 101 to 225 and break rest of 200 total prizes here again. You can win more than once. That's the key here, right? I know a lot of you bought in a lot Look back over here. We're gonna roll the dice. I'll show you really quickly how everything has kind of laid out Let me see. Let me see So here's kind of the sheet. I've been keeping track of So screen share here. So how it works is if it was a random style break You're gonna have the name and then the break name, of course They're all put together in the the same line on the randomizer if it was a PYT So I'm gonna PYT it'll have the team name And then it's just a lot easier to copy over a list of team names rather than actually type out all those names Because if you don't do that for a PYT, of course, so PYTs will have team name and then the break name Some of them are abbreviated. I had to abbreviate some to fit them on the line actually you can only have a certain amount of Lines in the randomizer or like characters per line That makes sense. So again, 6,110 entries. Thank you all so much. We had a blast break seem to go very well here It was tops chrome release week, too. I mean, I mean, what's not to love about that. Alright, let's roll the dice It's gonna be one random and then the top 200. That's a That's how it is Good luck That is a 12 of course. I rolled a 12 of course. I rolled a 12 on The national promo random. It couldn't be any other way the first dice roll I do have coming back. I rolled a f in 12 All right So we'll go 12 times here again Your name or your or your team name is on the same line as the as the break itself So good luck everybody 12 times again. That's once it after 12th. That's that's that's the results. Let's do it One could take a minute. There's a lot of there's a lot of stuff here two Three there's you go kind of fast four five six seven eight nine 10 11 and Good luck everybody 12 Jason are from Star Wars Sapphire five box number 14 Gets the trout Joey a 22 23 chronicles basketball 12 box case number four tiered you're getting the Jordan David S 2022 select football Asia team all 10 bucks number seven you are getting the Brady helmet I'm gonna I'm gonna scroll down a little bit I'm gonna scroll down all the way to the bottom and then copy everything over Move it over and kind of scroll through it again We'll find a way to get this posted to the sites where you guys can see it It's not gonna fit in our regular results But I think a shared Google doc or Google she would probably work best And I'll put these next to the the prizes as well Oh Man, I might I might just kind of click and drag here guys, but again 6,110 spots congrats to Those of you that Receive the promo item that's a lot. All right. I think I can refresh now This over oh Boy geez. Yeah, see that won't fit on a blog post on our website. That won't fit.  This will work right here No copied it wrong copy and paste it wrong Hang on let me How do I do this? There we go? That'll work. Yeah, so it copies back the exact same ways I copied it over So, yeah, I'll post this sheet So you guys can see all the winners So you'll have the the name or the team then the break and then the the prize If you got one miss their relevant. Yeah See, I'll kind of scroll through again here will em you're gonna get the swag bag from Prismi PL choice 10 bucks for 15 Bradley are you're gonna get the sealed case of Donner s UFC hobby that was 21 22 flawless basketball number 22 tiered And then silver packs and father's day packs You got Sam see the Giants in Chrome top chrome hobby case 6 Randy B in the Sunday Funday from this the only Sunday Funday Scott V in the top chrome jumbo case number nine and Jeffrey H from Sunday Funday. I Don't think I'm gonna read the rest. This is a lot, man This is a lot. We're gonna get a way to post it. I'll scroll down here so you guys can pause and kind of look over it. I Know it is a lot. I'm actually gonna make it bold, too. So it's somewhat Scroll down a little more here So again first column is the name or the team name Second column will be the break that it was and then third column will be the the prize And again one through two hundred. Yeah, congrats to the winners the the pro though that you receive the promos promote goodie here That's what I'm thinking can learn something that people can't edit. I think that's probably I think that's what we did last year I'm trying to think maybe Google sheet. Maybe just maybe literally this sheet might might work the best It's pretty clear Keep scrolling down here. Hey, man. It's It's how it goes, but I think last year the grand prize winner was like It was like a sub $100 spot. It was definitely less than 100. I think it was pretty low but That's probably what I'll do. It's probably exactly what I'll do Brandon Hey, no, don't knock Star Wars man. I was I'm buying Star Wars cards all the time. I love collecting Star Wars. I don't know. I guess galaxy got delayed I know they're supposed to do like the pre the pre-ordered thing on top stop on the post post point I was like, oh dang my snags and boxes Because that's not something that really ever Drops in value, but I know the last year's galaxy dropped a little bit, but I think it was because it was pretty high The team names and the name column is that's if it's a PYT So that's the easiest way to differentiate here. All right, where we had 65 Yeah, yeah, I mean, hey, that's that's the promo though Keep scrolling here. That was line 73 All right guys, so we do have obsidian soccer coming up in a bit here I got the combos listed the checklist came out late last night. So I was a burning the midnight oil and even the Early morning oil if that's a thing Putting together some the combos best I could so though they're listed in the breaks I'll drop some links for you. I'll have J drop a link right now. Actually for the first obsidian soccer We got score football release today as well I think we'll have two teams for finest left our finest case the two jumbo Random teams chrome cases are sold out for this morning Yeah, Sam's live this evening with more breaks Kyle's live this evening with personals on channel 2 We're gonna get some fanatics live breaks listed to do Thursday and Friday daytime for everybody so that'd be It's been fun beyond that platform. It's pretty nice over there. I'll keep it rolling here. Yeah, well, I'll make a public Nice 10 left to go good stuff. Yeah, well, I'll probably I'll probably literally just use this Google Sheet like legitimately just use this So you guys can check it out and See all the spots if you have any questions and Then just give us a few days if you did get something that needs to be shipped to get a ship to you and break credit Especially that's gonna think break credits gonna be the thing that takes the longest the input honestly But I'll try and get to work on that Today Tentatively today or maybe someone else will yeah, I don't want to Promise anything just give just give us some time. Just be patient. Give us some time.  I'll scroll down. Actually, I'm not even a scroll down. There's so there's so much There's so much But that will do it. Thank you all very much again. That was a great national at the shop and in Chicago We'll get these up for you


Welcome everyone. This is Melissa with the stocks question and reviewing target. This was a stocks wish play of the day yesterday in the room One of two BBY was the other one. I thought this would fall and drop and follow through from the previous day So we were not overly aggressive in this. Okay Got the short in here got the drop down and I thought this would fall down at least 118 It broke 118 went to 117 84. So here's what happened. This was earnings here So this was a play of the day in here again looking for subtraction. This could have fallen more But this was still a nice move more than a buck in the target again short yesterday and you know, this earnings really was Nothing spectacular. So it'll be interesting to see here again Have to watch the market the chart itself in target is actually in an uptrend But it failed on the earnings to move higher sold off hard for two solid days And today now it's Friday last day of the week. So we're gonna see where this is gonna go But could this move lower? Yes, even though it's in an uptrend with the market and these retailers have been having a lot of problems I had high expectations for this to have a nice bullish gap up in the earnings But it didn't do it. So we shorted this as a play of the day yesterday And it really worked out very nicely as a secondary trade If you're interested in more information in the Golden Gap course email me at Melissa at the stocks wish calm And if you want to try out at the trading room, you must take the class to join the trading room Then email me for a free trial next week. Have a good day everyone


Hi everybody, we're back, this is Dave Vellante, and I'm with Wikibon.org, and this is the Cube, SiliconAngle.tv's production, where we bring you the smartest people that we can find. We like to extract the signal from the noise and package it up and provide it to you. I'm at Dave Vellante, if you want to tweet me, at Stu is my co-host, and Stu's also with Wikibon, so if you have any questions or comments, please send them. We're here right now with another customer segment, we've been having a number of these customer segments at the Dell Storage Forum, a lot of good proof points. I'm impressed by the way that Dell is able to provide great customer guests and proof points. Donald Wilkins is the director of IT, a company called NaviCure out of Georgia. First of all, Donald, welcome to the Cube. Glad to be here. Thanks for taking time out, and this is actually your, I guess, first and a half Dell Storage Forum. The first one you said was in Dallas as an equilogic customer. This is the first full sort of, you know, belly to belly Dell Storage Forum that you've attended. What do you think? I'm impressed. A lot of good information, and a lot of good networking with some of these people that we've exchanged a lot of ideas, a lot of history of how we've grown with our infrastructure and how they've grown, it's been a good connection. You come to these events, and obviously the keynotes are good, you get good messaging and they're playing music, and it's very slick, but there's a, it seems to be a lot of rich breakout sessions, a lot of detail there. Have you been able to attend a number of those? I've dropped in on a few, and it's been very beneficial. I've taken away some pieces of information I didn't think about previously, and I've dealt with some of these technologies. We use VMware, we use a number of different options, and there's some things that I've learned. It's been a great experience so far. So tell us about NaviCure, what do you guys do? We're a healthcare claims clearinghouse. We handle healthcare claims from physicians as they transfer those to the insurance provider, the insurance payer. It's a strictly electronic form of data interchange. So we refer to it in the old days of EDI, and so we're after, we're all about making the doctor's reimbursement for his, for the insurance claims, a much better process. Okay, so I want to get into that in some detail, because you've got, you're very process driven, I'm sure, but before we do that, just tell us a little bit about your IT environment. First of all, your role as director of IT, I presume you're doing a lot of different things, but maybe talk about that, and then we'll get into sort of your environment. So I mean, my role at the company evolves every day. I mean, it's, I wear a lot of different hats, the mile wide, an inch deep methodology, so I know a little about a lot of stuff, and my whole goal in our infrastructure is keeping simple. And I don't want to introduce too much complexity in the environment because there's not enough really hands to dig deep into issues. I want to be able to make sure we can manage things in a simple manner. Our infrastructure has evolved through the years. We are a growing company, we grow 20 to 30% each year. Our customer base is continually growing, and each year that's just a magnitude, a multiplier every year as we keep growing the business. Our storage is ballooned, year after year after year we keep adding more storage, needing more performance, needing more capacity, and our choice for the Ecologic product has really proven itself over the years. How much storage do you have? We're currently just shot 400 terabytes of storage. We have currently 38 Ecologic arrays, which is the entire spectrum of their product line from the original flagship product shipping in their early 2000s, 2004 was our original purchase, to the current hybrid stuff that's shipping today. And how long have you been with? Eight years. Thank you. Okay, so you were there at the beginning when the company brought in Ecologic, you obviously involved in that decision to do so. Take us back to that point. What did the environment look like pre Ecologic? Pre Ecologic, we were a small organization, very small. We started the company with only four employees, I was part time at the time we started the company. We took three years of let's decide what we want to do with infrastructure. Let's outsource our storage to a third party provider in our data center, and let's see where the things goes. As we kept growing in business, growing in customers and we decided we need to end source our storage because we need more control over the flexibility we need to grow at the pace we needed. Having it outsourced really handcuffed our ability to grow, our ability to build development environments, to build test cases and do things and the outsource provider couldn't move fast enough for us. We need to move at a faster pace. You were outsourcing to a managed hosting company? It was a company that was in the co-location facility we were in that provided fiber channel storage for us. They basically carved out space for us and they managed it for us. In 2004 we got into a position we need to build more development environments, we need to have more space and so we looked at various product offerings, the larger names, the NetApps, the EMCs, and then we got introduced to an Ecologic and it's really turned our thought processes around when you can bring an array in, set it up on a conference table and turn it on and connect to it and use the GUI and really almost understand the product within 20 or 30 minutes of being introduced to it, which really gave us excitement around the product. We tried it for six months, we brought it in for development tests, we bought one for development tests, we liked it for six months, we decided to put it in production and we haven't looked back since. So you said you were employee number four, have I heard that correctly? Four and a half. Part time guy. At that point when you were evaluating the Ecologic, you were really responsible for that evaluation, right? For the last part, yes. Okay, so it was just kind of your call and that coincided with your VMware initiative? VMware didn't come along until a couple of years later. VMware came into the mix primarily for disaster recovery, looking at a way to one, grow our environment really fast, really quick and virtualization was the way to do it. We were at a turning point in the life cycle where we knew we had to add a lot of servers, a lot of functionality, a lot of different add-ons to our existing infrastructure. Again, when you're growing and you're starting small, you have very small footprint and we were starting to ramp up at a much faster pace. Virtualization allowed us to do that without the infrastructure of having all these servers racked up and having a deal of consolidation. Consolidation was not a problem for us because we didn't have infrastructure, but we knew we needed it years two, three, four, five, six later. So, okay, so the VMware came a little bit later. So I want you to take us back to that point at which you decided to go with this company from New Hampshire, right, that was a startup. You know, nobody ever got fired for buying IBM, right? And so you stuck your neck out and said, yeah, nobody ever, by the way, nobody ever got fired for coming on theCUBE, so. Now, where'd they go? So, so. Can we get back to the office? Yeah, yeah, right.  I mean, you're taking some risks there. Well, I mean, we did take some risk, but I looked at it from, I really asked this question at the time, we were a startup ourselves. Our customers have took a risk on us and we've proven it wrong. And I knew that, you know, maybe I need to take a risk on this product because I looked at the other products and I knew, you know, three, four, five years down the road, I got a fork lift and start over. And this technology allows you to bolt on and build on and keep adding to it like bricks, like you're building a building and you're putting a brick in here and a brick in there. You can build it as you need to, you can grow as you need to. And having a cash flow as a constraint early on in the business that needed, that really had to watch its dollars, which everybody does today anyway, but we had to really focus on that and so it allowed us to invest as we made money, as we needed to, versus buying everything up front and paying for all that licensing fees, everything up front, and then having to sit on it for a year or two as we had to plan for three, four, five years down the road. We could actually plan in a smaller segment a year or two because two years is a long time in IT and especially in our business where we're going 23%, that's a magnitude growth that we had to deal with. New product offering, a database explosion, all this just would be totally different in two years. And we didn't feel like we wanted to rip out and replace our storage every day for three or four years. That's interesting. So you had a higher risk tolerance than maybe some other companies.  Ecologic is a startup. Obviously you're focused on cash flow. That fit in nicely, particularly the perpetual licensing model that they have, which is I think very attractive. So you're not going to choke on maintenance the way you might with some other organizations. So there's that risk reward balance and so you took that chance and then works out and then Dell buys Ecologic. So what was your reaction to that and take us through sort of what's happened subsequent to that acquisition?  Hey, you know, don't break my support. I love the guys in New Hampshire. They do a very good job. Make sure you keep that group intact because you know, that's one of the reasons we're still that customer today. We love the product. We love the sports team at Nashua. They were doing a very good job. And so we were impressed. Don't break that for me. Because I mean, you know, not having that great success with some of the servers, you know, support in the past, we wanted to keep that great performance that we're getting out of New Hampshire with the support staff. And that was my initial concern. Then you look back and you say, well, Dell had a better economy of scale. Dell had a better way of taking Ecologic to another level and by themselves, maybe they couldn't have done it. Maybe they could. But definitely Dell allows them to be able to do that. Yeah, so okay, so subsequent to that, your concerns were nullified because the support was maintained, improved. I think Dell listened to all our existing Ecologic customers and said, there's something here. There's a reason why every one of these customers saying, don't mess with my support. And I think Dell listened. Dell kept the team intact. Dell kept the research and development up in New Hampshire and the level two, level three guys are there. They listened to it and they kept it intact. And since then, you know, they constantly, you gotta evolve it.  You gotta make adjustments. And they've been able to do that, keeping the core tenants intact. So what do you make of the announcements this week? They talk about the conversion for structure. Pete Kors was up on stage and he showed the shrunken equal logic array. What does that mean to you? Is that something that you're gonna be interested in or? Well, the Blade Storage Array was, it has some interest. You know, we're a lot bigger than that now. So it may not apply to our environment. Definitely, I would see if I was a, you know, getting into storage or getting into server consolidation, especially with looking at blade systems, it would be almost a no-brainer. Has a lot of value for it. But, you know, we've got a large investment already in equal logic and a lot of bigger units that provided, you know, our infrastructure. So it probably doesn't apply to us unless there's a special case for it. But definitely a smaller business or maybe a mid-size that is starting to, you know, add to the infrastructure, adding more sand storage, yes. So what's your IT environment like? Are your budgets growing? Are they flat? Are they down? You know, our budget grows some. I mean, we're in a 23% growth cycle every year. 20 to 30% of our business grows. We, and so that means we have to, we have to adjust our budgets accordingly. You know, of course we want to do less with more or do more with less. And so, yeah, our budgets don't grow at the pace of our sales and our growth in the business, but we do leverage new technologies, you know, new consolidated efforts and de-dupe and other things that allow us to, you know, kind of slow the growth and, you know, keep things in a night, a simple manner. But our environment, we have an Oracle Database. An Oracle Database is central to our operating. That database is 18 terabytes and that database grows at two terabytes annually. Good, sorry. And so it is central and we all run down on the ecological story. Now, we upgrade that storage every year, two or three, and we move that older storage to other environments where it's more suited. But we take it, so as we buy new storage, we look at what's the best stuff out there? What's the most best performing stuff? Let's put in production. Let's move the production stuff down the line to other environments that may not need that fastest stuff, but they need more horsepower, more capacity. So we're constantly shifting stuff around. Ecologic allows us to do that. Most monolithic chassis-based storage systems don't. Are you virtualizing the applications that are running on your Oracle Database? Oracle itself is not virtualized. It's a large Oracle Rack Cluster. It's a little problematic to do that. But our web servers, our Java middleware, and a lot of other things we run are all virtualized. We have a virtualization first policy like a lot of companies do. If I don't virtualize it, I gotta have a good reason. And it's gotta be something that requires that. Is the reason because Oracle is not really that friendly toward you virtualizing it? They have an anti-virtualization policy. Oh, anti-VMware. Well, that too. Policy, yeah. Well, anti-virtualization, anything other than theirs. Other than OVM, right? Well, why didn't you go with OVM? Okay, I'm biting my tongue in cheek here, but go ahead, tell me why you didn't go with OVM. VMware has many more years of R&D and product offerings that nobody matches today. We use Cyre Recovery Manager in our disaster recovery planning and Cyre Recovery Manager allows us to script our DR plan and most everybody else doesn't provide that today. That is a cornerstone of some of our virtualization. That's one of the reasons we try to virtualize everything because as soon as I virtualize it, I've got a disaster recovery process already in place for it. Have you thought about virtualizing your Oracle apps or Oracle database and dam the torpedoes or is it just too risky from a support standpoint? Well, we have too much CPU to deal with virtualization. It doesn't bias anything. Yeah, okay, so there's not a business case for it. We've got eight-way boxes and three or four in a cluster and they're 45% used. There's not a lot of overhead that we really think virtualization would give us. Yeah, so it's really not worth it. That's interesting. So what's the, let me ask you this. What's on Dell's to-do list from a storage standpoint? I mean, obviously we're talking about the things they do very well. Clearly a very happy and loyal, equal logic customer. What would you like to see them do a better job of? You know, obfuscating the different product offerings under Dell and making everything kind of come together with this fluid architecture is a neat design and offering that they're doing and allowing me if I had to put in a compelling solution or I had to back up to the cloud or I've got to do other things in my organization, build my own private cloud or whatever I need to do, they're taking all that and combining all these, the best features of all these different products and putting it together and saying, you can do that and you don't have to be an equal logic customer. You don't have to be a compelling customer to take advantage of this. We're bringing it all together. And so seeing they're doing all that and they're not like some of the other companies that, so while you got to bolt this on, you got to bolt that on, you know, they're actually taking the intellectual property of every one of these products and putting it in the other product and putting it here and putting it there whereas you're saying it's not an extra license feature here, license feature is there. They're just doing a good job of bringing it all together and I like to see more of this happen. And you know, kind of every time I visit something I say, oh, I could be doing that or I could be doing this, giving me thought processes for the next few years as we look to try to, you know, slow down some of our growth and data and our growth and acquisitions for more storage but also give me other processes with the caching of the SSDs on the servers that was announced this morning and what they're working on for the next year. That's something we're looking at. We're looking at speeding our customers, speeding up the response time to our application so our customers can do more and less time. So you're excited about the vision? I am, I am. I'm pretty excited. Did you take a trip to New Hampshire this week? Yes, I did. Yeah, how was that? I actually took me eight years to get up there and I'm pretty happy I got there finally. Met some good people, some people that I spoke to years ago in support and shook their hand finally so that was great. Yeah, I think if they're not the biggest, they got to be one of the biggest Ecologic Slice Dell employers in New Hampshire. There's a lot of talent in this area, you know, East Coast, mini computer companies and you know, the old digital crew. I know many of the folks have ended up in Ecologic so there's a good talent pool there and you know, as somebody from New England we're very happy to see Dell maintain that presence in New Hampshire. My other question before we break here is how do you, Donald, back up all your data? We use, so anyway, I'm a cyber recovery manager. It's integral to our disaster recovery plan but we use a lot of snapshots of replication. So snapshots for quick recovery. We replicate to our other facility for multiple copies and you know, some kind of a short term recovery. You know, we do send a tape some stuff for archival type purposes. We are in a healthcare space so there are some time requirements for us to keep data for seven years. So we do keep data on tape but we primarily rely on a lot of snapshots and replication and so we've had that since day one of the product. You got me taped at the end of the day if you want a cheap way to deep-archive it. That's the way we do it. And we didn't implement tape until last year so we've been snapshots of replicas up until last year and it's said, well, we're tired of buying discs to put this on, let's put it on tape and stick it in the safe.  So how about Appashore? Is that something that you're looking at? You know, we just made it, like I said, last year we just made an acquisition for tape software, probably not looking at it anytime immediate, maybe next year in a budget cycle. You know, what's key with Appashore is the integration they're doing with all the different products. That will make us look at Appashore. So you want to see that, like you were saying before and then that's going to just make it more and more attractive. That will be the piece that will make us really want to jump on that, say we've got full integration with Ecologic, we've got full integration with Confluent. Now we, and so, and plus it allows me to take a, like the analysis morning to take my physical box, if I have to have a physical, I can restore it to the cloud in a virtual environment with Appashore. That's cool. All right, Donald, well listen, thanks very much for coming in on theCUBE. Appreciate it. Really great meeting you. Outstanding case study, Dell. Listening to its customers, you know, we're seeing Dell really push the vision of integration. Customers like Donald want to see it faster. It's not trivial, but the fact that Dell is putting such an emphasis on this, to me anyway, is a real differentiator that I see in the marketplace from some of the other companies that we follow. So this is SiliconANGLE.tv's theCUBE. We're live from Dell Storage Form. Keep it right there. We'll be back with our next guest from Boston. Thanks for watching.


On air search for a missing 13-year-old boy resumed today in northern Minnesota, Gary Allen Tillander has not been seen since he walked out of his shelter for juveniles in Bemidji around 8.30 a.m. on Wednesday, February 22nd. Authorities searched the area of Highway 71 near Blackdeck by air on February 28th. Law enforcement in the International Falls and Kuchichin County area continued the air search today. Detectives have received information regarding numerous sightings of Tillander along Highway 71 near Blackdeck. Residents between 10 strike and International Falls are requested to check all campers, outbuildings or other structures. If anything is located that may assist law enforcement in locating him, you should call the Bemidji Police Department at<PHONE_NUMBER> or dial 911. Tillander is described as 6-foot-1 and 160 pounds with sandy blonde hair and blue eyes. He was last seen wearing a Black Flight Jordan Jumpman hoodie, red ball cap and light gray sweatpants. He's wearing black high-top Nike shoes. If you've enjoyed this segment of Lakeland News, please consider making a tax-deductible contribution to Lakeland Public Television.


Look at all these clean trucks If you guys watched yesterday's video you saw that they had the mobile wash guy come here and Wash as many trucks as he could in the day. He was here the whole day washing as many as he could I didn't get a chance to get mine in the lineup, but mine's still pretty clean from the other day We don't have a permanent wash bay here, but we have a mobile wash guy who comes here and washes all the trucks I don't know how often he comes but It was pretty nice Pretty nice to see him, especially in this season now that the the dirty season is behind us mostly the dirty season meaning Fall winter and the beginning of spring so six months of the year It's impossible to keep anything clean just because of the climate. I've explained this to you yesterday and so We're finally getting into the season where when you wash something it's actually clean for a while You know it lasts a little while more than 15 minutes So we already got our assignment for today Gotta go get the truck started I wasn't gonna leave it hooked up But since it got a little cold tonight. I wanted to plug the truck in just in case So I can get it started this morning with no problems I'm gonna go hook up to that Conestoga trailer again the covered wagon and pull it up to Arbor But two hours north of here, and we'll load her up and Bring her on back here for the lucky driver that the load we're picking up today is Going to end up in El Paso, Texas That's pretty cool. Good morning, my friend How's it going? Hey? You have a good night Well, she's got a little dirt on her stacks there now that's from yesterday.  I'm just gonna get some Some polish and some polishing tools just I know it's a work truck. Okay. It's a work truck I'm not expecting to make it look like you know It's gonna be an entry in Gats the great American trucking show what I can to try to at least Keep it as clean as I can right you got to take care of the equipment that you're entrusted with I have been assigned to this Wonderful truck here. She's a little bit old not the Not the worst either What's that We're talking about how beautiful you are so I have two older sisters, but They're older than me my my closest sibling in age is Eight years older than me eight or nine years older than me So I sort of grew up as kind of like an only child kind of I was so far behind them That was a lot younger than them and they were way too cool for their little brother It wasn't like that, but they had their own lives, right? And so I sort of grew up doing my own thing hanging out by myself Can you tell? Because I can have a conversation with pretty much any Buddy and anybody anything I want to including a truck and my dogs I'm perfectly fine. Just entertaining myself Okay, we got her all warmed up You're ready to rock and roll still got the steering wheel, but that's okay. She's beautiful. Okay She's beautiful doesn't matter So I got to go hook up on to that trailer 603 and pull it north I'm sure glad we had this extra GoPro hero seven Because I drove over my other one last Last after yesterday. I was gonna say last night, but it was late yesterday in the afternoon. I was tired It's time to go home And I was just gonna film myself parking and the wind blew my camera off the ledge where I had it and right into Where my wheels were going and I didn't notice in time and I drove over it with the trailer But she served her purpose and the cameras actually made a lot of videos probably made close to a thousand videos with that camera So we have this other one here that we had as a spare. It used to be Brits camera Now it's here so you guys are all nice and shiny right now this camera's brand new For the most part How good is we had this let's be extra careful with this one Off we go Petro pass here in Norbert quick little check in the trailer here make sure that everything we Knock the climb underneath it to the back over there And this is going all the way to El Paso, Texas But I'm just taking it back to where you are. We have another driver who's going down there I would love to take it though Now that I'm just gathering freight for our highway driver Now they got all these loads and routes going all over the US all kinds of places that I haven't been in like 10 years In California, Texas, New Mexico, Arizona, Nevada Those are all places that I always wanted to go trucking to Maybe one day we'll take a trip here or there, but for now they need me here picking up these things and I've also got things to take care of at home I'm liking the schedule a lot. It's working out really well for us Let's go and see. I'd love to take Britt with me But if she comes with me We've either got to take all the dogs with us Or we've got to find somebody who can at least watch the big guys, right? Or watch all of them. Dogs is sort of like having kids You can't just pick up and leave and go to El Paso in a truck It'd be very cramped having all of us in there and Britt can't just You know take two weeks off work to go down there and right now I've got a position here that I really like So for now, we'll leave that to our highway guys. Maybe they'll send us some pictures from down there But if you live between here and El Paso, so anywhere's down the i29 corridor, I guess North Dakota, South Dakota, Nebraska, Iowa Kansas, Oklahoma, Texas Today is uh, Tuesday the 24th of March 2021 If this is headed out right away, it'll be down there in a few days. It should be down there Uh, actually I can tell you It says right in my computer here when it's expected down in El Paso at the end of next week Not sometime next week. If you see this big blue covered wagon rolling through there with one of our trucks Give them a friendly wave. They may not know why you're waving at them. So Don't go and bug them. That's the trailer that I loaded A lot of the people here watch the videos that I make but not all of the drivers Watch my videos and not all of them know who I am so Maybe they'll wait back. Maybe they'll wonder why you're waving at them bad trailer. Maybe it'll be my dad He's still trucking. He's somewhere down and uh, where's he going? Where was he going? I think he's on his way out to new england right now In the area not anytime soon We're trying to make one of these things that you call a baby Very important and I need to be here for that Apparently it works a lot better that way And then once we have said baby I'm gonna need to be around To raise them for her My best memories growing up with my dad is being in the truck with them In the summer. So that's definitely an experience I want to share with my kids one day if they want to come with me If they want to go on a trip down to El Paso when they're, you know In that age where dad's still a superhero If they say I'd love to go on a trip, you know what? Well, I'll go with them for sure We've got to turn them into truckers somehow, right? Best way to turn them into truckers is to immerse them right in it My whole life that's all I've known is trucking, trucking, trucking and accounting. My mom's an accountant But I didn't take after that as much sitting in front of a computer and paperwork does not Excite me as much as Big diesel trucks Grab this thing back and the driver who's taking it down. I don't know. I have no idea who it is So we made it back here put this trailer in the loaded lineup For the driver, I was just going to show you How this lifted axle works in the back here because up until Just about a month ago. I had never pulled a trailer with a lift axle like that before I think they're pretty cool See the load is Light enough that we only need two axles on the ground to be legal But if I was hauling more weight in here And legally I would need three axles on the ground That's where this axle comes into play See how it's not even touching the ground It's lifted up by that airbag there And the way we put that down It's in a different spot on different trailers I believe it's up at the front over here in here See it's in the up position We just put this to Down like that You can see that deflates And the airbags over there push this axle down Now it's a tri axle If I go to the front and I flip that little switch to up You'll see it lift up Take a look at this Figured I shared that with you Something I haven't shown you before So the reason we would want that axle lifted up at all is two reasons On the long distance highways from here to El Paso Let's say because that's where it's going Having one axle off the ground reduces drag Which means that's one less axle the truck has to pull Down the highway saving fuel The second reason is pretty obvious, I guess if the tires aren't on the ground They're not getting worn down Saves on wear and tear and you don't have to replace the tires as quickly On a minnesota I thought maybe that one shipped out already I don't know, we got a bunch of those in the yard all the time We're always here Random bag in the yard that might be for the dogs So I moved the solar panel for that light onto the roof So we won't be able to see it from back here, but It's on the roof so it gets direct sunlight most of the day Now we're on the shade of that house already But man does that make a difference This light used to be bright and last for maybe like Three to five minutes tops In wintertime it would last for about one minute because even less sunlight then right Since I put that uh solar panel on the roof The last couple of days It stays bright out here all night For as long as you need it It's amazing what that little bit of difference does direct sunlight. That's what it needed Where'd everybody go? Just finished editing and I was gonna film an ending clip and They're probably outside, aren't they? Ah enjoying the light That I was just talking to you about And the lights I put around the yard to light up the perimeter Let's go see shall we? Let's go see. I was just talking about this light in the vlog before And I have seen the requests in the comments for more of brit and more of the dogs in the videos I understand. I don't always uh Show them because I get home really late sometimes And she's already in her pajamas and ready for bed and not really Not really in the mood to go and be on the internet at that time. Yeah, she's already all sleep attire And I'm really tired as well when I come home and I'm not really always in the mood to film when I get home yet so It hasn't been on purpose and bleeding. I agree with you. I'd like to have them in the vlogs more too They're the biggest part of my life And they should be in In the videos every day. Let's go see what they're up to shall we? Hello Hello. Oh, I found a vina It says a vina. He's in the dark. I can't see him There have been requests for more of you Mm-hmm little sure you're not talking to frank. No, I'm talking to you I want to see more of you So I was just telling them about this light. Isn't that a lot brighter now? YouTube's gonna dull it down anyways. Yeah, I can't really the He doesn't do it justice, but uh Yeah, that stays on for like as long as we need it now. It's amazing what direct sunlight will do You're just teasing me pretending you were gonna go to the bathroom and it's a no-go He does that a lot He just wanted to sniff around.  Is he gonna go? Behind the carport. Oh, oh, he's doing the waddle. He's doing the waddle Oh, no, just teasing us again. You want something on the lawn? Chevy out here Chevy Chevy, what are you eating over here? Chevy man, I love that. I was I was so disappointed already because I thought that we had uh Bought this, you know, it's a solar light. I didn't know how good it was going to be and I was so disappointed with it I was like, oh, what a waste of money and it's pretty expensive too Now I'm happy with it. Hey weasel Let's go inside. Come on every time you put footage from this camera onto youtube for some reason youtube automatically darkens everything and it's Not a setting I can change because you can go in there and brighten it But it just makes it look terrible. It doesn't actually bring the light back Just makes all the redness poke out. Yeah So there's that. I've always got to make sure I've got really good lighting. It doesn't matter what camera I use Other youtubers can understand I'm sure Okay, me and uh vakum here have a date