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Type 1 hypersensitivity reaction also known as immediate hypersensitivity reaction or IgE mediated hypersensitivity reaction because IgE antibody is the main mediator of this hypersensitivity reaction or in common terms also known as allergy. It is the most common type of hypersensitivity reaction to an external antigen which is also known as allergen because the body gets sensitized to this antigen and produces allergy so that antigen also known as allergen. So what is this type 1 hypersensitivity reaction? So the key terms here are that it is a hypersensitivity reaction in a previously sensitized individual and when there is subsequent exposure to this allergen there is rapid immunological reaction to this allergen. So one is the sensitization aspect. So what is this sensitization? How the person gets sensitized to the allergen that is the one aspect of a type 1 hypersensitivity reaction and then what are the responses that is the rapid immunological responses. So basically here the immune system is doing its job normally only however the responses become too much exaggerated. So what happens basically when there is exposure to an antigen which the person is susceptible to. So this susceptibility is determined genetically. So it's not that the allergen acts as an allergen to all the people of the world. Genetically there is susceptibility to that particular antigen and that's why allergy is seen in some individuals and not in other individuals. So when this antigen enters into the body just like the response to any other antigen what happens this antigen is recognized by antigen presenting cells and these antigen presenting cells are macrophages and what are the next antigen presenting cells? Dendritic cells. So these are the main antigen presenting cells. Now for any immune response it is important that these antigen presenting cells phagocytose this antigen. So suppose this is the antigen presenting cell and they have phagocytose this antigen this is the antigen they will break it down and create small small fragments of the main big protein. One of these fragments can act as the main antigen and then they present it on their surface by means of major histocompatibility complex. So a portion a fragment of this main protein is presented to other cells that is the T helper cells. So suppose this is the T helper cell and T helper cell here we are talking and not cytotoxic T cell because it is the activation of T helper cell which is important for activation of other immunity as well. So cytotoxic immunity and activation of the B cell everything depends on the T helper cell. So when this antigen is presented to T helper cell what happens that this T helper cell can further differentiate into two types that is TH1 type of T helper cells and TH2 type of helper cells and this differentiation depends on the cytokines which are released by these macrophages which are presenting the cell to the T helper cells. So when this macrophage releases a cytokine IL4 interleukin 4 this preferentially causes the differentiation of T helper cells to the TH2 type. So that is important because TH1 type actually enhances the cell mediated immunity and TH2 type of helper cell enhance the humoral immunity that is basically by the release of the antibodies by the B cells. So it is this differentiation of T helper cells to the TH2 type of helper cells that is responsible for the type 1 hypersensitivity reaction and remember we are talking only in susceptible people. Now once this TH2 cells form they also release different type of cytokines and major ones of these are interleukin 4 interleukin 5 and interleukin 13. Now this interleukin 4 what it does it is responsible for class switching of B cells class switching that is the B cells are there right which are basically having D antibodies on their surface the antibodies for recognition of the antigen directly. Now this B cell will produce which type of antibody whether it will produce IgG IgM IgE that is known as class switching. So they switch to IgE producing B cells IgE producing B cells okay so this is very important and as I told you before that IgA antibody is the main antibody which is responsible for type 1 hypersensitivity reaction. Actually these IgE antibodies can attach to a particular receptor on mast cell that is FC epsilon receptor so this is mast cell and this is nothing but the receptor for the constant portion of the antibody. See any antibody has two main sides right so suppose this is the IgE antibody this is the constant portion of the IgE antibody and this is the variable binding portion of the IgE antibody which is particular specific for a particular antigen and this constant portion is responsible for the biological properties of the antibodies and this FC part of the IgE antibody binds to this FCE receptor okay so here binds the antibody and obviously there is not a single receptor multiple receptors are there so this mast cell now is bound with many IgE antibodies on its surface. So this is known as sensitization that is with the first exposure of the person to the antigen what has happened that there is differentiation of T cells to TH2 type then there is class switching of the B cells to IgE producing cell and the antibodies which are produced go and bind to the mast cell so this entire thing is known as sensitization when there is subsequent exposure to the antigen now there is increased production or proliferation of this TH2 type of cells and it becomes much more efficient also causing release of the cytokines with now increased production of IgE antibodies so that is one second you see the other cytokines which we were talking this interleukin 5 is responsible for the recruitment of the eocenophils and eocenophils are very important mediators of typhon hypersensitivity reaction as well and this IL 13 interleukin 13 what it does it actually enhances the production of this IgE antibody by the IgE producing B cells so we have more and more IgE production which binds more and more mast cells also you see we talked about that mast cells which already had IgE antibodies bound to it so they will directly recognize the antigen and obviously more and more IgE is also going to bind to these mast so let us see now what will happen when antigen binds to these IgE antibodies which are present on the mast cells so the allergen binds here on the variable portion of the IgE antibody and you see when there is binding on the two or more IgE antibodies what will happen that there is cross linking of these IgE antibodies cross linking and this cross linking is essential for the signal transduction pathways which happen in the mast cell so that will activate the further processes which are responsible for the hypersensitivity reaction so they will be released of the mediators of typhon hypersensitivity from the mast cell and what are these mediators first mast cell has granules and the granule contents will be released so that is known as degranulation so that is the primary mediators of the hypersensitivity reaction and the granule contents includes very important histamine histamine is responsible for smooth muscle contraction right then there is vasodilation and increase in the vascular permeability increased vascular permeability across so that is why in hypersensitivity reaction the person has difficulty in breathing because the smooth muscle contraction has started maybe the bronchial muscle has contracted depending on where the antigen is present that particular smooth muscle contraction will occur then vasodilation increased vascular permeability what will happen that when there is increase in vascular permeability there will be increase in the fluid loss from the vessels and this will result in edema and vasodilation actually that will promote to continuous blood flow to that particular vessel and thus promoting more and more fluid loss from the vessel then histamine also causes increase in the mucosal secretions so like we see in case of allergic rhinitis what happens that the increased secretions occur in the nose then in the bronchals then in gastric glands there will be increase in mucosal secretion again depending on the site of the exposure then other important content of the granules is the enzymes which are responsible for tissue damage and they also lead to complement activation and this complement activation causes generation of the sub-products of the complement for example C3A, C5A which are chemo tactic so this will recruit other leukocytes to the site of the antigen exposure so you keep this in mind that other leukocytes are also recruited to the site of the antigen exposure and we have seen before that how IL-5 released by TH2 is also recruiting the eocenophils to the site of the exposure we'll come to this a little bit later so that is one aspect the degranulation of the contents of the mass granules then second major component is because of this cross linking and signal transduction pathway there is phospholipase A2 activation phospholipase A2 activation and this causes conversion of the phospholipids on the membrane of the muscles to the arachidonic acid which is responsible for formation of other mediators because different enzymes like cyclooxygenase and 5 lipooxygenase act on this arachidonic acid and lead to the production of different mediators in the coax pathway the major mediator which is produced is prostaglandin D2 and in the lipooxygenase pathway the major mediators produced are LTB4 leukotrin B4 leukotrin C4 and leukotrin D4 so let us see what are the actions of these mediators prostaglandin D2 is responsible for bronchospasm so that will lead to breathing difficulty and it also increases mucous secretion then these leukotrins they are very potent in increasing the vascular permeability especially this leukotrin C4 and D4 what they do is they increase the vascular permeability again increasing the edema and there will be obviously increased blood flow and remember that when there is so much blood flow to a particular area and there is vasodilation what is happening if this continues throughout the body then too much vasodilation will decrease the blood pressure it will decrease the peripheral resistance and it will decrease the blood pressure so it is producing shock like condition if it occurs systemically if it occurs locally then it is enhancing the reactions so increased vascular permeability and again there is bronchospasm caused by these leukotrins and leukotrin B4 actually it is again chemotactic for the various leukocytes that being neutrophil, eosinophils, monocytes so these all come to the site of the reaction so that is the second part of the response which is occurring from the mast cells third there is release of certain cytokines from the mast cells as well and these cytokines are TNF alpha interleukin 1 and interleukin 4 again they lead to chemotaxis of the various leukocytes so you see we have referred to this chemotaxis again and again we talked about the interleukin 5 which is released from the helper 2 cells then there is activation of the complement which recruits leukocytes and there are again cytokines released from the mast cells itself which is responsible for chemotaxis and you see here IL4 IL4 where we talked about we talked about that it is important for T helper cells being differentiated into TH2 type of cells and TH2 type of cells where it causes the B cells to produce in IgE antibodies so you see here what is occurring this is a positive feedback which is occurring so once the reaction starts it goes into positive feedback and the response continues okay so why I was talking again and again of chemotaxis and recruitment of the leukocytes to the site because when we talk about type 1 hypersensitivity reaction actually this hypersensitivity reaction has two phases one is the immediate reaction so if we draw it graphically say suppose x axis shows the time after exposure to the allergen and this is the point of allergen exposure immediately there will be a response that is due to the mast cell responses the degranulation the release of the arachidonic acid metabolites but approximately 2 to 24 hours later there is another reaction which is known as late phase reaction so this is early reaction and this is the late phase reaction so two reaction phases occur that is why I was repeatedly talking about the recruitment of the leukocytes because this late phase reaction occurs due to the recruitment of eocenophils neutrophils basophils monocytes to the site of the antigen exposure and their action ultimately leads to tissue damage okay and remember that this is important clinically because here we saw that what are the mediators mast cells are the mediators and histamine leukotrins are the main mediators so here the drugs like antihistaminate drugs or mast cell inactivators that may help but when the late phase reaction starts then these drugs will not be useful rather we need powerful anti-inflammatory drugs like steroids so that is the clinical significance of knowing this immediate reaction and late phase reaction and one thing before we move that as I told you before that eocenophils are one of the very important effectors of the type 1 hypersensitivity because this eocenophils release proteolytic enzymes and they are the ones causing major tissue damage before ending let us see certain examples of type 1 hypersensitivity now this type 1 hypersensitivity can be of two types that is either it can be localized to a particular area so that is known as local immediate hypersensitivity reaction or there can be systemic reaction that is known as anaphylaxis examples of local immediate hypersensitivity reaction being allergic rhinitis conjunctivitis then there is a bronchial asthma because it is also limited to the airways right so bronchial asthma is one example of local immediate hypersensitivity reaction then there are food allergies which again there is a restriction to the GI tract food allergies so these are examples of local hypersensitivity reaction then skin allergy also like contact with an allergen may be present in soap so that is also example of local immediate hypersensitivity reaction and if you see that this reaction depends on the portal of entry so when localized to the respiratory tract GI tract or on a skin so the response will be local however systemic hypersensitivity reaction occurs when there is either injection of the allergen so it goes into the blood directly or there is ingestion of the antigen and it is absorbed into the bloodstream for example peanut allergies they are example of ingestion of the antigen and the bee sting it is an example of injection of the antigen into the circulation so in these cases what is going to happen that there is obviously same responses are going to occur but they will be widespread throughout the body so as I told you that there will be vasodilation and increase in the permeability of the vessels what it is going to do that it is going to decrease the peripheral resistance and hence that will cause the decreased blood pressure plus there will be widespread edema because the fluid is leaking from the vessels throughout the body and this can lead to death as well because it will quickly lead to laryngeal edema which will obstruct the breathing so it has to be treated on a very urgent basis so that was all about type 1 hypersensitivity reaction thanks for watching the video if you liked it do press the like button share the video with others and don't forget to subscribe to the channel physiology open thank you


Yo, what's going on y'all mention boy DC young fly you did.  Tell them what we're going to do We're going to Maybe more but that's all we telling y'all for right now. What's the date? What's the date, man? I think let's July 24th. You hear me Seattle. Oh, I'm told with the first Remember oh, I told the same. We want to bless in Seattle Wells It's awesome. Okay, we may do that on the frat. Mm-hmm. We may do that on the frat We just gonna do it like this. That's why we got to get back on the road But my phone won't stick we can't even we can't even buy tape That while we still the trap every cake by tape, but you always turn up the microphone You think Domino's gonna sponsor this? They should Do what I'm saying Shout out to Domino. There's you know saying give me black boys. You know I'm saying the job Real talk, you know what to find all them dates while we eat domino at the on the website Plus new shows go to 85 shops you are that girl? Yeah I feel like if you go to the Instagram or click the link or something it'll probably take you with the tickets Man, you know what going on man the tool going crazy man. Should I say it again? We're gonna be in Biloxi sacrum in Charleston, Seattle and a little bit more if you want to know go to the 85softshow.com Negro, okay bet. Hey man. We're back We're coming to all them cities. He just named you did and some more cities come on and we came to see the 85% We don't have cities in the building I'm talking about this time put them pull them out We don't mean for a pregnant boy the tennis We've been missing them titties now one thing we can ensure we can't create a safe environment We can put them tits out. Yes, we can yes, we have proven that right. You hear me We have a grandma's smoking weed that's on oxygen tanks, and they have a Nigga can't say I showed on inspire I Talked to that lady family. She's doing well right now. She's doing good Salute man. Salute Yeah, man, so come check us out. How long you had this walker?   Oh y'all smoking blood No, we ain't not today, man. I saw you on the podcast a blowing weed all alone y'all like man My nigga no won't be around all that I've seen it we just beautiful. I watch everything we just beautiful. Hey, man. It is It can be J. O. N. You off the day of what? Oh cat Who we sounding like I want to I want to Everybody on See I said I said is everybody on 85 South shelf. We're gonna turn it up Have a drink. Please ain't bring no candy See what's happening?    No I am not me Yeah This is on them baby like I can't know so we take them in Mickey D's on the low No, I'm talking back at your tube. Oh, man, you're kidding.  We fought with we fought with you, bro You got an amazing story man, let me read off some of these mother some of the other accomplishments. We got paperwork today, man Jamaica Queens. First of all Legendary place, bro I've been traveling off since 19 years old But I always go back to the hood Don't get more hood than Jamaica Queen. They sell the big dushes 1997 high school parade player the year come on man, so you playing in the parade no Parade magazine Same a a u team is Elton Brandon run our test That's a team.  I think we only lost like like that team was like 63 and like three Four years man, I know that was like a two-year span we played That's a that's not a game.  Yeah, I wanted six million when I was shooting the reality show too of my xy.  Well, it's crazy, right? So the weather man, that's how it be man.  You never know your arm bro and some tumbling boots Because you never know and a knife could he crack it for real? You do even a knife right now. I was a dream come true though For real, but I think the blessing of it all was knowing what I was going to do from a young age You know what I'm saying? I think that was a blessing. A lot of the people don't find they love ever You know what I'm saying? So I was able to find minds out of love at a young age Man, the NBA life gotta be different man.  You gotta be strong. Yeah, it's hard. You gotta be strong. Well, you know, I'm saying gotta depend on God. Yeah First off Your family and your friends your loved ones.  You try to take care of everybody as much as possible. Yeah, you know what I'm saying? But of course you can't take care of anybody. You can't take care of people that want to take care of themselves first Try to bring some opportunities back to the hood And you always you say you always go back to the hood So if that that one kid that just walked up on you and be like, look my man How how can I do it? I watch you I watch you and I know you're from Jamaica. You know queen But like what is it that you can tell that young kid that's there inspired by your life? No, you just gotta be persistent. You know, I'm saying inconsistent. You know, I'm saying that whatever you want to do And like feel me Mama mentality Speaking of the mama man. What was it like playing with Kobe like that? legend The high was incredible Did you hear everybody talk about, you know, the actual mama mentality and how he just never came out of, you know The equipment best was full of everything you did It seemed simple just to say it. You know what I'm saying? But a lot of people can't do it Dude was like that with everything Early in the morning. He was he was a thug on that basketball court He was there early before everybody everybody and the last one And he was a thug out there Like he was talking that talking hanging on breakfast elbows in the morning Before the jump ball go up Going in. Let y'all know that this is my court and y'all interest. This is practice, but I'm we just pushing you You know what I'm saying for greatness.  Oh, what do you say?   Yeah siding this players up talking about literally We got that most handsome team and leaving all that. Who was that the white dude that owned the clippers We used to own the clippers. He's coming in and saying what? He's just like extra eyes on the players Little uncomfortable. Yeah, yeah, but his host that was chump real Can they find out the river man? Cause the river wasn't there man.   I hate that.  He was a dog No, don't get me.  Here we go Who y'all got taken with this year? Not a real fox. I'm thinking a real fox.   That's what I'm talking about.  Come on, man. No, we fault them hoes, bro They got they got my boy Lou on there now Lou. Lou. Lou ain't done came back home doing their motherfuckers I'm sorry Lou. What's up, y'all? He from up there I don't even really understand how the whole Atlanta thing go like so you got Atlanta's the city, right city The city that's it.  The mother cities they not It's not Atlanta know what it is. We might share a county. So if you live in um, give me some different places with Okay, so if you live in like when that that's far that's that way Up there when it is the city.  That's Atlanta in the middle. Everything else is Yeah, you know 285 is the freeway. Yeah big circle everything inside the circle is Atlanta everything But on the outskirt it's still Atlanta, but then that's one of the other cities get like Decada is another city big when it's on the east side And Decada has his own county called Decada county, but the east side 40 county does run on the east side a little bit And Atlanta runs on the east side But then they got Decada with then they got lot on here then they got stone mound Then they got Scott there. So the east side over the way bigger than the louis Which really is it love it takes a while to it take a while to learn the geography Yeah, you got you got to know because the other side of town is different though It just really depends on where you at. You know where you at? They said wait different y'all because New York Y'all got boroughs. Yeah, but if somebody say yo, it's five minutes away. It's five minutes away No, it's not not in new york out here Somebody tell you it's five minutes away. He's lying. You want a freeway?   I don't even think I could live in new york It's hard, bro. Now you I love New York.  I swear I do but I Give it to y'all every chance I get y'all some aggressive every time I get out that airport at jam.     I don't keep it real with you. What what? Say it say it say it. I know what you're about to say. Say it. You know we got this bitches my name You know we got this South the eight You just cuz you just like that home so to fit. We've been like come on in baby. He ain't a little hood That's the one thing about it Okay, you can be the girl of your dreams every day. She might have one more than you exactly You can break up with your chick and find another chick look just like her They couldn't even better That's what made me stay so long But because In a cute and they don't mean it. I think they would I couldn't do it. They live with too many people Her grandma living in the living room I don't never leave them.  I think I'm with the conan island nigga with my father firemite. Who's in the project?  Like you gotta do this.  Okay, then we'll make it, you know what I'm saying? Like he had fans, they were made of bright foods But I asked my guy, I said, bro, how much did she want? He said in the cream part about it Now here you live in the hood be paying 250 and shit like that Session 8, man, bitch, I was paying 1500 For the yuh the one the studio with the pool table 1500 and like I couldn't feel sorry for him if I'm like, nigga, you making 15 hundred My homeboy had an apartment. He stayed on the third floor.  It's like they demolished the second floor. Right.  It's ghosting that one But then they said all the builders in but this one on light.  That's best those Yeah, that's best those shit and they over time as it were at That's best those from the paint.  I ain't heard anything about Ain't that one of the traps since the day they built them bitches But that should make you great.    Y'all niggas, y'all niggas Y'all the first nigga that I know that, you know, the first state that I knew that had like Every nigga in there could give us a couple thousand Straight up, you could be from queen, brooklin, niggas, Harlem It don't matter.   But some of them didn't tell them A lot of them, they had to. They had no choice. They had to tell it Man, they had no choice.  Exactly. Where are you from? Mississippi.  That's the south south.  I don't know I don't know I just rolled past a sign when we left Mississippi show niggas It was saying like a master with 1866 or some shit About when the white people came to the town and kept the whole month in the middle No, there ain't no telling them. That could have been 1966 It's still bad, don't they like that? I don't know.  I think it's more They got that economic racism now where it's like all y'all doing good.   You give it. I'm saying I get it It ain't even no illusion.  There ain't no more No, I'm down here in 11 somewhere You gonna hook me up?  Where you trying to go? Who you need a nigger? I'm the nigger, need a no pay Bad credit, no credit, get a provence Let me know when you're trying to move Hey, commercial coming soon, man.  Man, come on, man. I am the landlord I hear that, my boy You did What? I pull up, be outside like the mark, man.   I try to get the bag, bro NBA is over, man You got to go crazy, man You feel me? I don't think I'll leave the NBA and go with the first full money Nah, I'm just trying to work, man.  Trust me Just chill Just chill?   That, too. That, too. Get a lot of A lot of Get a lot of it because of the NBA NFT, you know the NFT? Hell, yeah.  Yeah, sir Ethel's gonna be like another Bitcoin movie Yeah? Keep going.       Oh my gosh I already told a nigga his wife tastes like honey in a cheerio A legend Hey, I'm Carlos Miller Two out of three men with experience Some form of hair loss by the time they're 35 Keeps offers a simple stress-free way to keep your hair There are only two FDA-approved medications that can prevent hair loss Keeps offers both Low-cost treatments Started just $10 per month And Keeps offers generic versions Keeps has more five-star reviews than any of its competitors Discrete packaging and proven results Prevention is key Treatments can take four to six months to see results so act fast If you're ready to take action and prevent hair loss Go to Keeps, that's K-E-E-P-S dot com slash 85 south To receive your first mother treatment for free That's K-E-E-P-S dot com slash 85 south To get your first month free K-E-E-P-S dot com slash 85 south It's literally that simple He was like we was playing with Darius Miles so Shout out to Darius Miles Oh D, what's up with it? So we had Darius Miles and we had a real athletic team And what we was playing at the temple was one night And we was like a lot of dunks You know what I'm saying?   KG brought it to house like why he chose that?       White people What's the name of the song?   June 11th, man June 11th You don't know when you find that?  Like on streaming or some shit?   You got a cold?  The hood, Mississippi I'll tell them that Everybody Everybody got $59.90 Do you got a cold? So we can help you I don't know You know Do you have a cold? So we can punch it in That's gonna go straight to you I don't know You need to ask these questions Bruh, have you thought about this? Like worst case scenario What do you mean worst case scenario?  How you gonna explain that? Now I thought we was just going Man, he got up under me I don't know, man We're coming back in August for part two That's funny I mean, well, I ain't gonna be no money in the rematch Ass I ain't gonna be no more money in the rematch It might be, though I'm coming to the fight If you lose, I'm swimming on this family We gotta win, we gotta lead with a W What's the matter, dude? No, I'm just saying I'm gonna ask you one, the first round, second round, or third? It's only three rounds No, don't do it What? How many rounds is it? It's only three rounds, celebrity box What I mean?   Have y'all there?     I got you in on my boy Lamar, man Move me, man But just for what? What is this? For charity or Yeah, it's for charity See where I am Which one?  Yeah Right out there There's a good reason to move somebody out Crane here I see Hey, man, welcome back to the 85 South Show We over here Talking shit with Amar Odom Trying to promote this next fight Clayton, you jumping in here? You better not take Eric off the side either I had to break you in First of all, what's up, man?   Who, Jake Paul? What?   What you goin' for? Hey, man What you miss the most about playing in the NBA?   You round these dudes More than your family Who was some of your best friends that you made playin' in the league? Luke Lawyan Bruh What? I would never expect that What? We playin' for For real, the ladies They could be playin' for the ladies on team For a long time Yeah Oh, they want them old niggas to deal with Like, wins them and shit I swear he started coaching half way through a game Yeah I listen to that I listen to the loop Cause I'll put on a suit Hey, that guy said, Hey man, run the triangle What do you know?     Like where you think you was going to get drafted to? Right I thought I was going to get drafted Probably Third No, I I thought it was going to be second I thought it was going to be cool was going to take me They took Steve Francis Steve Francis And then I know I was, I knew I wasn't going to go to Charlotte Cause I didn't work out for them individually I mean, I know the clippers would probably take me But that's just like a dream come true For real Tell your story So, um, I'm getting drafted I got drafted, right?  What was your first big purchase? Ooh, lamb off Straight up out there No, no, no, I always wanted a, um My dream car was the, um, excuse me The, um, the wide-body business of 500 That's the only thing I ever wanted You know what I mean? That big All right, honey That's it You, when you got it, what was next? Had it in all black The six? No, it didn't Didn't set it Nigga, you gonna know? Oh, the X6 motherfuckers, though Fuck, if I do, if I got any dream car It's the Porsche and the BMW 86 That's the idea The Porsche? The Porsche You know what I'm saying?  That's what I'm saying That's what you can even get The sports going on Everybody look at me like a Porsche Yeah, it's a Porsche nigga That's out the window for me Yeah I can't do that Most of you catch me and there's something That's probably the Panamera Porsche The Ford Porsche Yeah, the Ford one That's nice See the Panamera motherfuckers See, I'm still with the Cayenne Cayenne me So you said when y'all won the championship You had got a Rolls Royce as a gift? Yeah What happened? You had got a what?  Give me a Just give me an old said money call or a sound Just buy me a Asheville van She talked about she wrote that A Phantom? With the stars or the stars in it?  With the Phantom or the?         You need them to trust you Right Right If you want to be around them Right You know what I'm saying Trust is everything Yeah You know what got me here Oh, look, you been here a lot You gotta kick that nigga If it's somebody that you like That you want to be around them Like how you said, like instead of love You feel what I'm saying?   How's it represent? That's the manager before you really meet the person J-Wen, we need to place a pen behind now That was one of them ones Yeah, man That was one of them ones That deserve a good talk Because I think everybody feel like the beginning Always be the best Oh, man And after that later, peel off, people are like Yeah, motherfucker You're like, what? That was lovely Man, she is Would you marry another famous woman?    For real That was a nice way to say it Way that I know Speaking to women with good jobs I would say to get married That would be a You have to have drive Just as much as me You gotta be equally yoked You gotta have that Just as much as me You gotta want to do better You feel me? You can't be a settler What you mean by that? Can't be complacent Yeah, you gotta do the best of everything Every year has to be a progress Why not? Sounds like a lot Yeah, everybody been asking Sounds like a lot Why you ain't got married yet, Carlos?  What do you mean? What you mean? I'm up there I didn't work What do you mean?   Why? Because we got love for one another We know what we act Peacefully and spiritually And physically You feel what I'm saying It don't mean we have to be enemies The fuck? Oh, they hate that So people only know we know how to feel it, right?  Has she ever like broke your heart? That's the Bishop Darnwall here, say You know what I'm saying? But when you find out she fucks with a little nigga, then what?    Okay, can I even say this before... Remember when we was talking about earlier That God made Eve a phantom And he told Adam to guide Eve Uh-huh But the moment we started listening to Eve Is the day we get kicked out the garden Amen Amen See, that story was deeper than rap Is it coincidence that deceive Has the name Eve in it?   You gotta be a snake?           So a lot of these things, you got to see them before they even hit the league Yeah, I was watching these so much I swear in my mind, you know what I'm saying? You're trying to turn them to me I've been watching this nigga since 11th grade It's only three people that I've really been watching since school, bro Like, I can call from back to back I watched Kevin Durant from school Chris Paul from school And I watched JJ Reddick from school Like, I know You couldn't left JJ Reddick off You crazy? Duke? Duke?     He still hasn't run, I think Call them run I don't know run because I was like 12 Y'all from San Diego? They just started ignoring run one day Y'all from San Diego?  The league? Hey!   Right I was waiting, I lost I mean, we on your side, I know I didn't know what to say in there Nigga, we was on the bus So we don't know, we don't know Nah, so we don't know I can't remember I can't remember if it was after a game And they told me to behave That's bullshit Oh, one in his performances But being with just like y'all I'm better than Mike Who? Who was that? Oh, being Just out of nowhere? I don't know, what made him say that I don't know if it was after a game That way it's not So it's just niggas on a bus Nigga, I think it was the only one that heard them though, two of them Just, he would just say random shit like them I'm not, it was just I don't know if we was talking I can't really remember how it went down But he was like, y'all, I'm better than Mike I was like All right, that's a lot But if you think it, man Go great If you like it, I love it Right Feel me? He believed it Hell, yeah, he believed it Yeah, yeah, 200% he believed it He was the only one at that time like chasing Mike Really like, y'all, I'm gonna be better than Mike Jordan To the walk, to the fadeaway Yeah, everything Yeah He practiced the game to the tee though He got it right, but he was still Competing Right, he was like Kobe, he was still Kobe He made it look like it was Kobe Even though he knew who he was, he knew who he studied And of course, he was his mentor But he was just like, I have to go on the court And outdo my mentor because it's like, this is the game He's teaching me the rules in the books Why am I going in and playing? It's the ultimate competitor The ultimate competitor is you want to be better than the one, the only one that they even could compare you to, right? Right You feel what I'm saying?       Yeah So you gotta go over what's in Who was the Cyrus nigga?    Right, nigga, you ain't even getting a game Like why did he even get in the shower?  What layup line? You ain't swear The layup line of one way That was three hours ago Exactly Your nuts still stick You mean, bro From what?    Shorty yawning over there Who? Tell me We're shorty I don't I don't Put the bucket Yeah I mean, I'm at one time They got that I still went in anyway Up to six players on the court I went on I said, I'm gonna get on And you get a referee We're looking like Who getting out?       Or did they pick it out? No, but I always use boxing training You know, it's my best year at the Lakers So I know what to expect Do you take like all the training or was it boxing? Like jiu-jitsu and shit?   Yeah, they got no jiu-jitsu, huh?      How many? How many? 12 strokes and what?     That's true, y'all I just want to give me some money Everybody knew it was happening Say cheese


He is a Swiss Digital Nomad that enjoys building solutions online. He is also a partner at Human Made, a top-tier wordpress agency and VIP partner. There he oversees the growing product of product portfolio such as Nomad-based, Happy Table, BT, Remote, and so on. Today he will discuss the possible path to success for anyone interested in working with WordPress. Remote working or generally being part of this movement. Ladies and gentlemen, let's welcome the loud talk to the stage. Who's coming to the after party? Oh come on, so much excitement. 8 o'clock as a car? Cool, I'll be there early, everybody else will be too. So, I came across this interesting photographic the other day and it shows the most popular jobs in the US from years ago to now. So back in 1978, let me see if I can move this out of the way a bit before I do something stupid. So back in 1978, the most popular jobs were farmers and stakeholders in the US. 20 tahun lepas, kita melihat bahawa yang paling banyak perempuan dan penyakit telah diperlukan dan kita telah mempunyai banyak perempuan. Jadi, terima kasih kerana mempunyai perempuan. Menurut saya, kita juga telah mempunyai perempuan yang sedap, dan itu mempunyai perempuan komputer. Dan itu adalah sebuah yang baik 20 tahun lalu. Jadi, cepat untuk sekarang. Dan kita melihat bahawa kita biasanya mempunyai perempuan komputer dan lebih banyak perempuan. Jadi, banyak perempuan seperti kita. Sebenarnya, saya membuat perempuan pertama saya pada tahun 1995. Apabila saya membuat perempuan itu, saya sangka saya melakukan sesuatu yang salah. Kamu tidak sepatutnya membuat perempuan. Saya tidak membuat perempuan yang benar. 10 tahun lalu, 2005. Saya masih tidak fikir itu adalah perempuan yang benar. Itu masih bukan perempuan yang benar. Sekarang, pada tahun 2015, saya mempunyai perempuan yang benar. Sangat hebat. Jadi, semasa ini bekerja, saya sedang membuat perempuan yang benar. Dan bahkan, sebenarnya, sangat popular. Sebab itulah hidup saya. Kamu boleh berjalan-jalan. Jika kamu dapat menerima perempuan yang benar atau perempuan yang benar, kamu boleh bekerja. Kamu boleh menjadi perempuan digital dan sebagainya. Kamu boleh menjadi perempuan yang benar. Tapi perkara yang ini tidak adalah perkara yang hanya berubah. Web juga berubah. Web design tidak hanya web designer. Kita telah membuat perempuan yang benar, membuat perempuan yang benar dan yang benar. Dan itu adalah sebahagian dari hari-hati. Dan saya rasa bahawa yang benar atau yang benar atau yang benar adalah sangat banyak perniagaan. Dan saya rasa bahawa perempuan yang benar dan yang benar dan sekarang, ia menjadi perempuan yang benar untuk perempuan yang berbeda. Dan ia menjadi setaikan perempuan yang benar dan sebagainya sebagai perempuan yang benar. Dan kami melihat itu di atas banyak perniagaan. Dan kami melihat itu di atas banyak perniagaan. Dan kami melihat perempuan yang benar dan sebagainya. Itulah kita. Ia adalah petang teman saya yang lebih sedap. Tapi kita lihat apa yang kita ada. Kita lihat ada perkara hari ini. Ya, ada. We got the athletic muscle. But the change happens instantly. You don't switch pages, you don't do anything like that. It's right there. dan ada sesuatu yang berlaku di rambut. Saya mungkin akan mempunyai sebuah kota, tetapi anda tahu, kita tinggalkan sebuah warna yang sangat berinteraktif semasa kita boleh melakukan semua sebuah kota tanpa mempunyai sebuah pakaian. Ia sangat hebat. Kita ada pengalaman ini sebab... Kita dapat mengalami kisah dari beberapa minit atau beberapa saat untuk menggabungkan website dan mengerti apa yang kita sedang mencari. Jadi, kita akan menggabungkan setiap keputusan yang orang-orang ada hari ini dalam termasuk apa yang mereka inginkan dari website ini. Ia sangat tinggi. Sebenarnya, ini bukan untuk berkata All websites are becoming platforms or web applications or complex tools that need to be like that. But rather that consumers are just seeking these experiences now. The modern front end for a lot of websites is JavaScript power. It is bringing in data from various APIs. And one way or another, it has a very fine on-page interactions. So in many ways the kind of work we do with WordPress and everything else will start gravitating towards these higher sets of expectations. So if platforms and web applications and all these cool tools I showed you represent one end of the spectrum and what we used to do normally or nationally represents the old way of doing things. And I came across this great example of this old way of doing things last week. I saw a company online they're advertising web services and they're doing per-page pricing. Do you guys remember? Do you ever see that? Or they charge $200 per page or $400 for two pages and maybe you get a discount if you have three pages? It's really weird because we just don't live on a web that works that way anymore. Do you imagine calling a company up and paying on a K? A lot of people have a website. One page. Cool stuff. He's going to call us in the future. Yeah, he's going to scroll. How does this work, right? It just doesn't. But now obviously with this idea of this past and the future in mind of different ways of doing things most people building websites and it definitely includes us as the WordPress community and this is where I'd say that WordPress as a collective freelancers and agencies and all that kind of stuff can sometimes feel a bit stuck in time. That's if we're a part of this closed ecosystem. We might go to work camps but not job script conferences. We might go to work camps but not like a PHP Con or whatever it is. And not too long ago people who sold web services as part of WordPress would install WordPress maybe a premium theme add some plug-ins and maybe do some custom CSS. And today that's evolved to include custom theme development and probably some light plug-in functionality. And when I talk to people in our community I often get the impression that people view WordPress as this self-contained unit.  So I'm still not sure if calling yourself a WordPress developer is the right sort of wording or if you should just be calling yourself a developer. But let's try to figure it out. Generally speaking though we need a different perspective that WordPress is a tool which is used with other tools. And not a solution which is simply deployed with themes and plug-ins and then those themes and plug-ins in WordPress go live somewhere out on the countryside by themselves and they won't talk to anything else. So I guess what I'm trying to say in this roundup that way is that moving forward in WordPress is a lot more about moving out of WordPress yet continuing to use it as a foundation to manage larger ideas. So if you consider the traditional WordPress website this is what it's usually like. It's front-end powered it's WordPress theming use WP admin for all the content and we're able to easily install plug-ins and themes from WordPress.org or other platforms. If we go a step further we have a publishing platform where we're still using WordPress admin but then we're disconnecting the front-end and using it in a decoupled fashion so we're using something as React or Backbone or Angular things that you've seen today whereby we have this JavaScript powered front-end and we're able to do whatever we want on the front-end but then communicate very nicely with the WordPress backend through the WordPress API plug-in. And this is where we're kind of at now in terms of a lot of clients are asking for this kind of product where they're getting the best of both worlds they're getting a JavaScript front-end they're out of the language of the browser and they're receiving WordPress as a backend tool so that people can author content manage content, change it, whatever it is. So it is this great situation the next step beyond the publishing platform is the application platform whereby we may not even use WPM anymore in any significant way to create content rather just to capture and manage it. I know this sounds confusing right now but I'll show you guys some examples. So Human Made which was briefly mentioned before is the company that Tom Joe and I own we're about 38 people around the world and we've done work for Sky, Airbnb, PayPal bunch of different companies and most recently I think it was Greenpeace and we launched it, it was pretty fun. One key difference between us and a lot of other agencies is we don't really consider ourselves a WordPress company we try to stay open to different ideas which is why we consider ourselves a technology company even though our work is 100% WordPress. So earlier this year we organized a day of rest actually quite a few people in this room were there which was a conference on using the rest API and it was really amazing seeing all the use cases there and all the examples were mostly around decoupling the front end again so what I was talking about before in terms of using WordPress as a publishing platform as opposed to disclosed WordPress and it's a really simple example because it does highlight the actual decoupled state this is our website it's WordPress powered but it uses React front so we use React.js on front which means that when you click between different tabs it instantly loads so there's no page search so the experience is a lot quicker and this is a very simple example of how that works we also have a small button in the bottom left which shows the API request but this project is actually available on GitHub so you guys can all check it out that's super easy to see but the basic setup and the principle here is we're using it as a publishing platform we have WordPress and then React grabs the data from WordPress that's pretty straight forward for now it gets more complex when we start doing more things so Adam Tables is another platform that we have for restaurants so we aggregate all the different tools that they have so we add terminals where they have the where they receive tickets the point of sale online orders, payroll, inventory whatever it is they never run a dashboard so this dashboard runs in not really real time but more like near time so it's usually 5 or 10 minutes deleted but this is not for the context of this it's on a website and it's a dashboard that sits on a wall yet WordPress is power man similarly we also send out emails based off of that so WordPress no website no front-end we can be ingesting data from one place processing it and then setting it out by email but in this case all the servers and all the waiters so that's also fun to give you guys a bit of an overview we take a bunch of data from different places store it with custom post types and custom post types for me at least was the sort of turning point where I was like, this is WordPress that's really cool I got to WordPress in 2009 and then custom post types came out in 2010 and it was just like why is everybody else not getting so excited about this you can create any kind of data structure you want easily show again on your website so to me custom post types and REST API together are incredibly powerful yet they're not that complex let's look at another example Nomadbase is a tool that we have for people who consider themselves location and environment for other workers nomadic and we have a nice little tool here which is a single page application in that regard where I can see now my entire capital map and also see who is in a particular city and that's all fed through forceware data twitter check ins, instagram check ins so we'll see here right now there's probably a couple of us here John's here Gary's here Sharon's here it's pretty fun but again all WordPress powered and again it's a similar setup where we're taking information from a lot of different APIs and processing and capturing inside WordPress and pushing it out to different places so this is the real nature of WordPress as an application platform who saw the talk on Amazon Alexa before no and you guys Hida are you here because you had such a great talk on using WordPress in a GUI-less fashion I wanted to remind everyone what that was the right side might be a bit more creative and it has a bit more imagination but the left side is certainly correct and that was a great example where Hida was using one echo to give it speech functions it was feeding into WordPress and then other stuff really really cool I was really surprised to see that Jokes aside if we come back to the idea of what are the jobs out there and what can we or sort of popular jobs where is this all going and let's imagine for once that software developer becomes insanely popular how do you as a developer or someone working predominantly in WordPress stay ahead of the game for lack of a term I think the first one is learning JavaScript I know it's something that's said a lot especially in the last year but it is insanely valuable WordPress is mostly built on PHP and it is a backend tool but if you want to be able to use the full power of WordPress you have to understand how it fits in the larger ecosystem the second is start with the end in mind if you have a vision of building something stick to that vision and work your way down in terms of what you can and can't build as opposed to thinking these are the tools I have at the bottom and then trying to work your way up from that because that's that'll limit you a lot in terms of WordPress way of doing things or some older way of doing things whereas there's a lot of cool things you can do with JavaScript you can build anything you want that's the beauty of it so having this sort of unlimited vision in that regard is really important I think and lastly it's proposed to anyone who develops on WordPress to make it invisible or in the Hides case it's whereby WordPress takes a backseat and plays an important function but then allows you to still do a lot of cool things in this case who uses Slack in here yeah a bunch of you so this is our Slackbot and where is Nol it just pumps it out and saves it in chat but this is again WordPress powered so this is the same Nomad based app I showed you before we created a couple custom endpoints for it and Slack now is able to use that data so if you can take one thing away from this talk it's not only about working inside of the WordPress ecosystem but understanding that WordPress is but just one component in a much larger industry that is growing in many different beautiful ways so at the end of the day build a full shed and see you at the end of the party thank you well we might have a video program for Nomad based point just Nomad block would you want to use it I'm happy you're fulfilling me how do I get in for a restaurant or to play with GitHub for the restaurant ah okay so the dashboard is just to go back you're talking about this right so the dashboard in this case is WebView so it's open on Chrome or any dashboard so we usually purchase the dashboard for a restaurant and then we have a full screen button which is just like a JavaScript line that makes it full screen but yeah that's how we build it so it's it's not connected to the dashboard or pre-installed on the dashboard it's just requires an internet connection if it's for a restaurant specifically then questions cool thank you


What's going on you guys welcome to the single guy channel. My name is Lloyd today. I had a very special guest here mr. Dave Barata was going on guys Dave Barata is here. We are going to dissect some horrific text conversations that some of our Followers viewers they shall remain nameless have sent us and basically what we're gonna do is we'll be getting a lot of questions From guys wondering how to not be needy over text. Well by the end of this video. I think they're gonna know how to Alright cool. Let's get right into it. Basically this first text conversation This is kind of we've changed a few of the details around And it's basically a situation where it was going well with a girl. He got this girl's number They made plans to meet up later that day. So this is him texting the morning of so Dave Why don't we when you read us the first message that he sends. Let's dive in so the first text man This one's a doozy Good morning with two emojis and a kissy face So what do we think about that good morning text when he was your opinion of the morning text So a lot of people say oh you like send a good morning text Like it's a it's a good way to be sweet to a girl She's gonna love it women say this to a lot of women say that yeah But that's not really the case like there's no reason to be texting a girl before nine and there's just not Yeah, good morning already not starting off in a good what do we think about all those emojis, too Yeah, I mean some emojis aren't bad I mean especially in your first conversation when a girl doesn't really know you yet It can help you kind of express yourself a little bit more But there's no reason to go hammer out with two emojis. It's just not a good text man It's just a bad precedent for the interaction. That's a very bad precedent my opinion about emojis look man If you like doing emojis, I they work for some people I don't use a whole lot of emojis, but that's just who I am but this is too many already So she responds with a hey, how are you so it sounds like she's playing ball, right? She's playing ball a little bit. It sounds like she's playing ball so far.   I can't wait to see you girl Like that's not what she wants exactly and it's actually a selfish text if you read into the nuances of it because what he's really saying is Hey, say you miss me back and we're gonna see the next text message. He says after that I was gonna read it right into it. So she doesn't respond real shocker there man I can't believe that can't believe that right and then at 8 59 a.m. He gets nervous and he says all right. Do you miss me too?  That's one of the most painful texts. Maybe of all time You guys want to know what it's like to be needy over text message. You see it right here So basically Yeah, exactly what we thought was happening and then even then she responds. She goes yeah, okay That should pretty much to let him know that he needs to stop doing what he's doing right now Change the pace completely Yeah, what he's doing is seeking validation. He wants to know okay. She misses me. She likes me This is gonna go well He needs that confirmation to feel good about himself to feel good about the interaction because at the end of day He doesn't believe it. He doesn't believe it doesn't believe in himself and that text message says it loud and clear to the girl She knows right away. This guy is not confident. He's insecure Exactly. I don't want to see this guy. Yeah, let's let's delve further into the cringe So the next thing he says is good Drop the two more bulging there just to just approve the point just to bring it home Yeah, exactly and then no shocker. She doesn't respond after that because there's really nothing to respond I mean even if it was going well, I wouldn't expect her to respond to that and then so 941 a.m. Passes It's about you know an hour or so whatever he's starting to sweat a little bit and then he says are you excited? Are you excited for later today? So he's trying to confirm the date Which I assume which was what he was trying to do in the first place He might as well just be like hey, I'm a huge bitch. Are you cool with that? Yeah, pretty much and then she says yeah, actually I might have a lot of work so I'll let you know So she's not cool with that.  She shows up to either. I bet my life she's in trouble. She bet she's not showing up for this day And we're gonna stop it right there because there's really no need to continue looking at the rest of this conversation I would say in generally there's a few things that we could touch up on here What do you think about it when girls say I'll let you know is that generally a good thing? Definitely not when a girl says I'll let you know that's big big red flag that she's gonna be flaking But she's a flaky present in general. Yeah, it's probably a sign that you either haven't set up the date in a specific You know straightforward manner or you haven't confirmed it the right way So she's giving you this wishy-washy response. Absolutely man. Yeah, I think look maybe once in a blue moon It's okay, or maybe there's certain circumstances where she literally just doesn't know her schedule and then she really will let you know But most of the time I would say they're saying that because they're probably gonna blow you or they're saying it Maybe they might see you but they're seeing if there's something better, okay? I'll let you know means hey like you're not good enough to put in my schedule quite yet So I'm gonna see if there's something better and then maybe I'll get back And it's no surprise after a conversation like this so she might have been thinking hey I'm down to meet up with this guy at the beginning, but then he just kept swinging for the founder No, I don't know how to explain what he was trying to do there, but he basically just shot the bed in every single way Killing a chance of her meeting up. Yeah, and it might sound ridiculous But guys like honestly look at the messages. You're sending sometimes I guarantee you some of you people are sending a lot of these messages that we just outlined So if you do any of these sorts of things, you're probably in the wrong place and this girl Another example of this type of text that a lot of guys by saying is instead of being like do you miss me? I might be like oh did you have fun last night? Just just to try to get that validation. Oh, she had fun Okay, yeah, this is awesome. Yeah after a date after yeah, so yeah cool So let's go into the better version of this which is a lot shorter Yeah, I mean we're right here. We're keeping it simple because keep in mind There's really only two things to two reasons you need to be texting a girl right that's either to build rapport with her Especially if you didn't get a chance to do so when you when you met up with there And then the second reason is to set up the date.  Absolutely. Absolutely. So in this basically have the same message He's sending it a little bit later around 10 32 a.m. So he's not texting you're like right when he wakes up He's waiting a little bit What's texting right now Not that that's bad, it's not that's horrible to text her at 8 30 She's probably waking up to that's the thing she's probably waking up and she's not in the mood to text this guy right off the bat You know, she's not her best mood either whereas at 10 30. She's a little bit more open up. She's getting her day started Yeah, yeah, just a little bit more relaxed So hey and then so this is what he says he says hey I got to do some errands later today. So I might be five minutes late, but I'll see you around seven and Then right after that she says oh totally okay. See you there Perfect, dude I mean there's not really much else that needs to be said a couple cool things that I like about this message if you guys are Worrying about being needy on text is that he's basically saying hey, I got to do something So I'm gonna be five minutes late now look no one's gonna cancel a date for being five minutes late But it does give them the option to tell you if they're not gonna show up So if she was gonna blow them off that she wasn't playing on show enough. She's like, oh, no, that's totally okay I have a lot of stuff to do. I'm actually not gonna be able to make it.  Yeah, definitely So yeah, you guys if you're wondering about how to get your text messages up to par and like how to text girls in The right way talk to girls in the white right way and attract them Hit us both up like we know what we're talking about and we'll break down a couple more of these if you feel like they're You guys are wondering how to become a better man as well as get the girls that you want in your life I recommend you check out Dave's channel is there anything they should know any links that they should check out for your channel I have a couple texting I have a couple really good texting videos as well if you want to see more of those and also yes It's gonna help you get the girls you want become the man you're meant to be so Also, let me check it out. We'll put the links in the description there And if you can't see them on the screen, you'll check in the description and they'll be right there So thanks a lot you guys good luck out there


The article discusses the challenges of sequencing genomes or genomic regions with extremely biased base composition using current next generation sequencing, NGS, platforms. The authors have developed an optimized library preparation procedures suitable for low-quantity starting material and tolerant to extremely high AT content sequences. They show that their optimized conditions, which involve a PCR additive, TMAC, produce amplified libraries with improved coverage of extremely AT-rich regions and reduced bias toward GC neutral templates. This development will greatly benefit sequencing clinical samples that often require amplification due to low mass of DNA starting material. This article was authored by Oiala Samuel O., Otto Thomas D., G. U. Young, and others. We are article.tv, links in the description below.


In the early 1950s, there was an idea, back-of-the-mind idea, to start a Mumbai edition, but for various historical reasons it wasn't done at that time or couldn't be done. But I think it's overdue because the times of India is way ahead, the number one player here, but the others have entered the market and I think we have something to contribute in terms of trustworthy journalism, relevant journalism and fairly comprehensive coverage and also a forward-looking outlook. So I think we have a place here and it should be surprising if we didn't enter at some point. It's taken a long while, but this is a good time to enter because we are now on a growth path. We had a couple of difficult years, but we now are clearly on a growth path, both in a business sense and also editorially. We've been recruiting people after some years of cost control and so on. So I think it's a good time to enter and this building, of course, is a location and building, plus journalists, these are a great asset. The differentiator will be our credibility and reliability, our reputation for serious journalism, but also in recent decades for diversifying our coverage, our excellent sports coverage, for example. I think on cricket, Shashank Manohar was interviewed in the Hindu the other day by Jeeva Svanath. I think he spoke out and it's made international news for those who follow cricket, cricket info and various sites have picked it up because what he said was extremely interesting. So and then you have science and you have lots of features, our coverage of the attacks, the terrorist attacks in Mumbai, terrorist strike, I think it was second to none because we went back to those families like the New York Times did after 9-11 and did that. But readers here were deprived of reading it the same day unless they went online. So when people used to ask, why don't you come to Mumbai? I'd say read or go online and read it free or you go to a repaper, but now I think you've got to distribute it at home because there is still a demand for print, the print newspaper here, a growing demand unlike several developed countries where print circulation has been an uninterrupted and terrible decline. So here I think there is still scope for producing copies of printed newspapers. It's still in demand although younger people also increasingly read it online. You've got to do both. We also have very ambitious digital platform plans across apps and covering it in a different way. We have Sports Star Live which is a new publication. In fact, on the screen different from our print edition. We have a Tamil paper which I think will also, we're not printing it at the moment but there will be interest here among the Tamil speaking people here. So the Hindu brings with it a lot of synergies and the question why so late is still relevant. We can't fully answer it but all that I can say it's a very good time to come. I think if I am to give credit to one individual it would be Rajiv Lochand, a fairly youngish managing director and CEO. We were very keen on getting him. He was not available earlier and when he accepted we were delighted and the first two years I think he fought heroically because it was a period of cost cutting. We had two difficult years but now I mean I would say if one individual can be given credit for turning the company around, the business around, it's Rajiv Lochand because it's clearly, I think he's here today. He flew in. He had some other commitments but he's come in for the day and he'll be at the press meet and follows this. So Rajiv has turned it around and now emphasizes that we are now on to a path of growth in every respect growth. He can elaborate on it but I'm glad you asked that question because and he's a man of real integrity. We knew him from Mackenzie. He was a partner and had stepped down because he wanted to work in, I think, foundations want to do enough of the high life you like and so on. I think I was involved in a public health NGO when we snared him, if you like.


Hello people of the internet, my name is Johnny and welcome back to yet another news video. Today's video is all about the Fazbear Fright books, because for the past couple of days we've had a lot of brand new info released about the books. We got all the chapter titles for book number 8 Gumdrop Angel. We also got a preview of book number 8, I have a summary to read out for you guys. And then of course the headlining news story for today, the cover artwork for book number 10, Friendly Face. So let's not waste any more time, let's hop into it, if you're brand new to the channel, make sure you subscribe. Even if you are subscribed, scroll down, double check, make sure you are still subscribed.  And let's get right to the point, the reason you clicked on this video, it's in the thumbnail, it's in the title, the cover artwork for book number 10, Friendly Face. This is it, and my goodness, what, what, what is this?  Whether that's a mask or an actual face, I don't know. Based upon the eyes, I'm guessing it is an actual face. And based off of the name of the book Friendly Face, I have a strong suspicion that that is a real human face on that cat, Scott, what are you doing to this franchise? To give my honest opinion about this cover artwork, it hasn't fully, you know, stuck with me just yet. I find it very strange looking, but at the same time, I do find it extremely terrifying.  Yeah, a lot of people are saying that it looks like the mask of the puppet from FNAF 2. I can kind of see that, but at the same time, it's also a, you know, a white face. I don't know if it's going to be about the puppet mask. We have seen the mask of the puppet in previous entries in the book series, so I don't know, maybe. Let me quickly read to you the summary for Friendly Face. FNAF fans won't want to miss this pulse-pounding collection of three novella-length tales that will keep even the bravest FNAF player up at night. Act in haste, repent at leisure. After losing his friend in a terrible accident, Andrew can't spend his money fast enough on a happy companion, guaranteed to keep his friend's memory alive. Scott quickly flushes his brother's creepy new pets, but the creatures have other plans. Eager to put her classmates in their place, homecoming Queen Jessica doesn't stop to double-check her homework. Reprogramming a defunct animatronic in the 10th volume FNAF creator Scott Coffin spins three sinister novella-length stories from different corners of his series' canon, featuring cover art from fan-favorite artist Lady Fizzy. Peter's Beware!  Yeah, I mean, with 10 books in, you know how this works. This cover of Friendly Face, the one with the cat and what appears to be an actual human face, will be about Andrew and trying to keep his friend's memory alive. So my guess is, that face that we see is his friend.  I don't know, Scott's weird. I do think it's a little weird because the story about Mott quickly flushes his brother's creepy new pet, but they have other plans. That could also be the story, but again, the cover is always the story, always the first story in the book. But again, creepy pets, I mean, it's a cat with a human face, but again, this will be about Andrew unless there's some changes that we don't know about. It's also worth noting that the book is now 272 pages exactly instead of the 224 that it was originally. So now this has the exact same book pages length as book number two and number three. I don't know if this is true, but apparently 224 is the placeholder page number for the books. Again, I don't know if that's true. That's what I've heard. But that is now the official length of book number 10 and also the description and also the cover. God, it's so terrifying. Moving on now to book number eight, Gumdrop Angel, we got a lot of info on this book. First up, we have the official story titles, the chapters in the book. In fact, some people have actually already gotten the book. Number one is Gumdrop Angel, of course. Number two, Sergio's Lucky Day. And number three is what we found. Now I'm not going to have any spoilers, but apparently this book is insane. And thanks to Google Books, we have the most common terms and phrases from book number eight. As you can see, there's a lot of notable names like Hudson, Sergio, Barry, Angel, of course. I do see Dale and Jake, two characters that we do know are already in the Fazbear universe of the FNAF franchise, Dale being the, I believe he was the CEO of the VR game and help wanted. I'm not saying he's in the book story because I again, I haven't read it. But yeah, we also got Jake, we have Faith, Claire, a lot of people, Violet as well. And of course, we have Freddy's and Granny, which has capitalized Lewis as well. So it looks like Scott took inspiration from MatPat with the whatever story the Springtrap baby was from. And now he's looking towards Lewis to make a story about good old Darko's games. But yeah, that is all of the common terms and phrases. Kind of interesting. And finally, we also got a extended digital preview of book number eight, Gumdrop Angel. Now, it is quite long and I'm also not allowed to share it directly with you guys. So it's linked down below. Or I also have a summary for you guys that I'll read right now. Thanks to Good Morning on the FNAF subreddit for the summary. The preview starts off with Angel in a box. Her eyes feel horrid and her body is weak. This seems to be similar to Step Closer. Angel and her family are visiting Freddy Fazbear's pizza as part of a party for Angel's little sister, Arphelia. Bianca, who is Angel's mom, has recently married a man named Myron, who can not only afford the party, but afford tons of horse-themed decorations along with toy horses for each kid at the party. Dude, that sounds like a banger party. Some filler happens with Angel developing a crush on a man named Dominic and giving her his number. After getting back to her table, Angel watches the performance and Arphelia blowing out the candles in her cake along with the animatronics. The animatronics have air blowers built in, kind of sus. After the kids finish the cake, a giant gummy statue, known as the Birthday Gummy, is lowered from the ceiling and is seemingly alive. This is my first time getting this, so I don't know what the hell is going on. The gummy must have its toe eaten first and the children will then walk up to the head. The head has a gumdrop nose, which only the birthday child may eat. Arphelia decides to take the gumdrop nose home. Angel and her family visit a horse table so that Arphelia may get a horse and a pony. Some filler happens with Angel talking to a girl named Tammy. At home, Arphelia puts the gumdrop nose in a treasure bowl made out of real crystal. Angel gets a call from Dominic and talks to him before her dad finds out, causing her to have to hang up. The preview ends with Angel arguing with her dad as she wanted student loans for acting school. Only to be rejected because Myron can afford it, even though he refuses to give Angel the money. Alright, so I think we can all definitely say that Angel is going to be the one to eat the gumdrop nose and turn into the gumdrop angel. I'm pretty sure we all suspected that when we got the name of the book and also the description because, you know, gumdrop angel the name lines up with the name of the main character in book in the first story, you know? So it just makes sense that she'll get mad, you know, she'll be jealous. I'm pretty sure that's even the description of the book, right?  And yeah, that is all the news we have today on the Fazbear Frights book franchise. It's coming to an end this year, which is so sad. I know a lot of people, including myself, really enjoy these books, but, you know, 12 is way too much. So I'm glad Scott is finally, you know, putting the series to an end at number 12. But yeah, that's it. If you made it to the end, make sure you're subbed. You've hit the like button, and I'll catch you all on the flip side. Goodbye.