Welcome folks, this is Tom O'Brien of TFNN. We have five days a week, we go seven hours a day, we go 24 hours a day on the internet at tfnn.com. Always remember folks, whatever you think about, you bring about whatever you focus on grows. Hope everyone's having a great day, safe day. Let's make a great night, folks. Always do your best, express your own divinity. You don't need the acceptance of others, you don't need knowledge or great philosophy concepts. You have the right to be you and express your own divinity by being alive, loving yourself and loving others. Make it wise, let's take a look at it out here. We have the Dow Industries down 82.  Gold contract up $5.70 straight at 18.10 an ounce. You got silver down 14 cents, $20.46 an ounce. Light sweet crude, flat, $90.58 a barrel, notes and bonds, a 10-year note, down 12-6 straight in 1-19-15, 30-year off 7 at 142.11 and Kingdala. Kingdala's down 56, 106, 386. The number to keep your eye on in the dollar, folks, is 106.752. You got the, where are you hiding? I thought I had this straightened out. We get the Euro out here at a price point of a 101, the pounds at 120 and the yen is at 135 to one US dollar. iPhone number's<PHONE_NUMBER>. Give us a call, folks. One note's going on in your world and the world of the S&P's, let's take a look at them. What do you have? Well, this is gonna be pretty cool watching this shakeout because check this out. I'm gonna put this up just an intraday, you know, just to basically a line shot, but what you're gonna see here is that the S&P, this is the future. There's been trying to get by this downtrend, okay? Now, we have volume. Each time we've hit this line, but it hasn't been able to make it, man. You know, and when you set up where the strength is, the strength is still at the top. You can see this, you see that expansion of volume in the last 10 minutes, that was 27,000 contracts. The prior one, they had 21,000. Now, the prior one there, I couldn't make it by with 37,000. Then we had 76,000. My take is that we're gonna bust through here coming into the close. So this is gonna get really interesting. Why? Because when you look at the daily, right? Now let's bring this to the daily. What you're gonna see on the daily, this is a pullback with dramatically lighter volume.  You're at 32 million shares traded. You're going at the 56 million. That's in the spy. We go take a look at the NBX 100, the three Qs. Three Qs right now, get 31 million shares traded. That 31 is going into 53. So we'll do like 44, wouldn't likely. And of course, what ended up happening yesterday is that we went higher with 44 million. Now let's just go to the dollar and cut to the chase, man, because the dollar is the name of the game. So dollar right now, bottom line is making its way back. It had a low today of 105, 969, rejected, lower price. It's hanging kind of, well, not kind of. It's definitely hanging, once again, that it wants to try to get up above this 106, 792. That's the crucial area, folks. That's the bottom line. What we had done on Friday, you got above it, close below it. Yesterday, you got above it, close below it. Today, just the opposite. You went lower and they rejected lower price. So that's telling me it's going to try to get into that once again. Gold, we go into the gold contract. We look at the gold contract. Now we get an expansion of volume from yesterday. I'd like to see a lot more volume. When gold wants to go top side, you normally get 178,000 to 225, in the contract volume. Right now, you only get 114,000. You know, yeah, it's peaking its head over, you know, last Thursday and Friday, but the bottom line is that it needs more volume in a monster way. If we look at the higher volume inside the NVX100, what's moving it, you got, Vertex is up 1.6%. You got AstraZeneca up 1.4%. Excel is up 1.2. And Kraft Times is up 1.2. Taken away from it. AMAT's down 8%. You got LAM Research down 8%. Marvel's off 7.8%. You get Zoom down 7.3. So you get some big numbers out here. Let's go to AMAT for a second. So we look at AMAT. Let's see how this baby's set up. Whoa, okay. So you get a gap down. Just trying to get into the higher range. Gaping down, right there. What is that? 96, 96 and we're trading, low as 97. Yeah, this can get the 96 pretty easy, no doubt. Let's go take a look inside the Dow industrials. The strength versus the weakness out here. We have point-wise, this is what we have. The Dow's down 85 right now. Putting positive points into it. You get United Health putting 23, Big Mac 16, Travelers 15, Microsoft 10. Taking away from it. Salesforce minus 52, you get Home Depot minus 41. Nike is minus 26 and you get IBM minus 21. Well, some of the higher volume equities that we have out here, and this is gonna be a light volume day. You have Intel is down 78 cents. You got Microsoft up a buck 68. Chevron's up a buck 40. These are is down 314. Amgen is up 152. And let's go take a look at a couple of the big dogs. We got Amazon, there she is. Amazon right now is trading down a buck 85. Is Disney out today? Is it, let's see, 10th, is that? No, it's 10th tomorrow. So Disney's down 139, trading 107, 325. Same thing with Disney. Disney went higher yesterday with volume.  That's a, this is a small ABC up, man. Yeah, Disney's gonna come up with good numbers. So Disney yesterday, just volume of 13 million to pull him back with five. That five is pulling back into 11. And we take a look at this, we set this up. Yeah, let's, that's 109.70. Oh, this is a good ABC up, man, hold it. 109.70. Yeah, that's nine bucks. That gets you 115. You're at 107, that's an ABC structure up to 115. So that's not a bad situation. Last time with volume on the way down was 120. Well, let's look at that one. That's 105, the next one's 128, I think. Yeah, 124 would be the next one. So there's some juice there. We'll see whether that gets some follow through. Chipsector, the SMH is that's getting smoked out here in a big way, there's no doubt. And what does happen, there's no doubt, man. Where the SMHs go, that's where the market wants to go. So this is gonna get interesting watching this shake out. It's down 981 right now, trading at 229. And we take a look at this, and this is down on volume, man. This is definitely down on volume. So, oh, this is interesting though, he hadn't, so I check this out. And that is it, the bottom of sign of strength yet. Excuse me, folks, the bottom of sign of strength is 225.42. If this is it, that's gonna be an interesting man, because the individual equities have got toasted, no doubt about that, but that hasn't made it to the bottom of the strength yet. Stay right there, folks. Come back with us, man, Mr. Basil Chapman.


Hey y'all, what's up? My name is Sonali, welcome to my channel. If you guys are new here, definitely hit that subscribe button and if you guys are already subscribed, make sure your post notifications are on so you don't miss any of my videos. Today I'm answering one of my most asked questions and it's where do you buy your bras? I'm gonna share some of my favorite stores to purchase bras at and some of my favorite styles. So let's get into the video. As you can see, I'm a part of the Big Boob Club and I can run from like a size double D to a triple D. I honestly don't know why it's different. Sometimes I'll go to Victoria's Secret. They'll tell me one thing and then I'll go to like a Soma, like an actual bra store and they'll tell me something different. So it really just depends on where I go but the first brand I wanted to share with you guys, unfortunately, does not have like an actual storefront which makes it so hard to shop for bras and honestly, nowadays I feel like there are a lot of bra companies that are solely online so it just makes it that much more difficult. This really shouldn't be a surprise to any of you guys because I'm obsessed with this brand but the first place I love bras from is Skims and first of all, I'm a big Kardashian stand but also like these bras are so comfortable and they come in so many different colors that actually match your skin tone. Like I could wear this bra under a white shirt and you wouldn't be able to tell. First off, we'll start with the T-shirt bra. I'm not sure what size this is because it rubbed off. Like I feel like all bras do that. You just wash them so many times and they just rub off but this is in color Sienna, I believe. What I love about the T-shirt bra from Skims is that it has that underwire but it doesn't have any unnecessary padding because my boobs are already big. Like I don't need them to look any bigger. I just need them to be like shaped and just pulled up a little bit so I really, really like this T-shirt bra. I need to order more. I literally bought a black one of this but I have no idea where it went. But the thing that sucks about Skims is that I feel like a lot of their stuff is always sold out and I'm not sure how often they restock. I'm gonna go ahead and link everything down below just in case it is in stock. So cross your fingers that it is but let's go into the next bra that I'm obsessed with from Skims. This is the bra I recommend to everyone. I know it looks really small but it is the most comfortable thing ever. Like the material is everything. I love wearing this when I'm just lounging at home and if like a going out top or like, you know, just like a running errands top like lets me wear this because you know, obviously it's straight across and it doesn't have like a V neck so if it doesn't show, I will wear this over the t-shirt bra. It truly is that comfortable and it actually just gives you so much support for something being so stretchy and it doesn't feel like you're wearing anything. So if you had to buy one bra from this whole video I highly recommend the Scoopneck bra. I think that's what it's called. I also have it in this color. I think it's named Ochre if I'm not mistaken because this one's Sienna and it's a little bit darker but seriously guys, these bras are heavenly. The last Skims bra that I love is actually in my dirty laundry. So I'm gonna show you guys a picture of it. I love this bra when I'm wearing like a deep V neck flowy dress or any like dress really. I don't use it for lounging too often just because it does give me a little bit of spillage because it does have that deep V neck but it is so comfortable like the material of it. It's almost like this mesh material in the inside and then it has a similar material to the Scoopneck bra on the outside of it. I would definitely compare this bra to a bra let with just a little bit more support. Skims is honestly one of my all-time favorite brands in general but I do have a second favorite bra brand for like more of like a sports bra feel. If you guys watch my vlogs you've probably already guessed it but it is set active. So these are all pretty much sports bras. It has this red texture so it actually gives you a lot of support. I'm actually wearing one right now. I think this is the V neck or something like V. My second favorite one is the body crop and it's just kind of like a tank top but it gives you so much support and it just kind of like sucks you in too. Highly recommend the leggings too if you're gonna get the sports bras but you don't need to obviously. This one is definitely my all-time favorite. This is the one-shoulder bra.  I would definitely get the one-shoulder for like more of a lounging like cute look because it does have like a little bit of spillage like over here obviously but you can always like hike it up. I definitely still do my 12, 3, 30 workout in it and it's like fine. The beautiful thing about the one-shoulder bras is that I actually have been finding myself wearing it under so many tank tops in mind because they're all like razor back. I also recently bought a one-shoulder tank top and I'm able to wear this under it and it's like perfectly hidden because the straps are kind of like on the thicker side. I feel like I've been talking about set active for years now and there's a reason because it just makes me feel so confident.  So I highly recommend set active because obviously you can get like the matching leggings matching biker shorts. Their brand has expanded to so many more like matching sets like sweatshorts and sweatshirts and all of the things. I think they're even doing swim next so I'm really excited just for their brand as a whole. Also their Black Friday sales are actually insane. I got so much stuff. I actually put it in a vlog last year so I'll link it down below but I'm definitely going to be looking out for their sale this coming Black Friday. I've honestly been looking for the perfect strapless bra but I've yet to find one so if you guys know of one definitely leave it in the comments down below. If I'm not able to wear any of these bras under like a dress or a shirt but I do need something to cover this area or to lift it a little bit. I highly recommend these. I'll put a picture right here. I've gotten them from Amazon and they work wonders. You can actually get them wet again like clean them and they'll get even stickier. So basically you just like plop it on your boob and then you lift it up and you like stick it right here. And so your boob literally stays up like that. It's literally magic. It works so well. I've also been dying to try this skims boob tape. I just have not gotten around to purchasing it. But if you guys have tried it, let me know in the comments.  There are honestly so many other places that you can shop for bras but these are personally just my favorites that I wear on the daily. You can also go check out Soma which is a bra place that my mom used to take me in like high school college. Their bras are really high quality. They'll last you for years. They're just a little bit like grandma-y. I don't even know. Whenever I walked in there I was like I'm literally in high school. Why am I wearing these bras? But, you know, they worked. And then if you wanted to explore some more lounge bra options, you can always go to Urban Outfitters, Aries, and try to think of anything else. But I feel like those are the two that come to mind. So I hope you guys enjoyed this video. I hope it helped you guys out. Check out the links in the description box and let me know if any of these bras work for you. I'll see y'all in my next video. Bye.


After knowing the nature of peptide bond and the rotations which are allowed in a polypeptide chain Pauling and Coray concluded that the simplest arrangement which a polypeptide chain could assume with its rigid peptide bond is a helical structure which they called alpha helix. So in a alpha helix polypeptide chain is coiled round and imaginary axis so there may be an imaginary axis. So along this axis this helix is this helix is helically coiled. In this helix the R groups they lie outside the helix while the main backbone is contained by the C-N-C-N-C-C bonds. So this is main backbone and R groups which are bulky groups they lie outside the polypeptide chain. And in this helix this is one complete turn and this is repeated unit of this alpha helix. It is about 5.4 angstrom long and it contains about 3.6 amino acids. So there are 3.6 amino acids in a single turn of alpha helix and the length of this single turn is about 5.4 angstroms. So this is alpha helix. The helical twist of the alpha helix found in all protein is right handed. What is meant by right handed? If we say what is the direction of a helix we cannot say either it is clockwise or anticlockwise. These terms are not good for helices. We will say it is right handed coiling or left handed coiling. So this alpha helix in the proteins is right handed coiling. So it means if we say this is the right hand and this thumb is the axis of the helix and as the fingers are coiled around this thumb similarly our right handed helix is coiled in this direction. And if it is left handed coiled that means it is coiled like this. So alpha helix in the protein is right handed. The repeating unit as you saw in the last slide is a single turn of the helix which extends about 5.4 angstroms and includes about 3.6 amino acids along the long axis of the helix. The amino acid residues in an helix have confirmations with psi values ranging between minus 45 to minus 50 and 5 values of about minus 60. So in the helix peptide bond is rigid that doesn't rotate but the other bonds adjacent to the peptide bond they rotate and the values of their angles that is psi and phi this is given here. And helix makes optimal use of internal hydrogen bonds. So in this way by using maximum potential of the hydrogen bonding this structure becomes stable structure. So in a helix almost all the amino acids are hydrogen bonded with some other amino acids. As you can see in this picture the nitrogen contains hydrogen. A hydrogen is attached with the nitrogen similarly oxygen is attached with carbon. So a hydrogen bond is established between amide hydrogen and carbonyl oxygen. So these two amino acids one amino acid this and the other one is this. So these two amino acids are linked together through hydrogen bonding. So all the amino acids present in this helix they all are hydrogen bonded. So this helix uses the full potential of hydrogen bonding of the amino acids and normally one amino acid is making a hydrogen bond with the fourth amino acid next. So first amino acid will make hydrogen bond with the fourth one. Second amino acid will make hydrogen bond with the fifth one and so on. So in this case all the amino acids are hydrogen bonded and this structure becomes very stable structure. So as you know alpha helix is one of the prominent structures found in the protein molecules. So about one fourth of all amino acid residues in a polypeptide chain are found in alpha helices. And in some proteins like keratins the alpha helix is the prominent structure.


Hello everybody! E here. Welcome back to another Book Review. Today, we are talking about a book that has been not requested, been recommended to me by dozens of people over the years ever since it came out. Let me see when it came out. It seems like it's been just mentioned over and over again, especially during Halloween. Let's see here. This one came out. Oh, it's only 2016, so it hasn't been that long. But yeah, so the last days of Jack Sparks, excuse me, my nose is driving me nuts today. I don't know what it is, something in the air, seasonal change, something like that. I don't know. But anyways, the last days of Jack Sparks by Jason Arnott. I'm going to go ahead and get the bad stuff out of the way first because there's a lot of it, and then we'll talk about the good stuff. So right off the bat, this book is written in the first person point of view of one of the biggest douchebags I've ever read. I'm a fan of reading about characters that I don't like, characters that may be morally ambiguous, they might be terrible people. You, well, not you, you rock, but you by Caroline Kepnes, fashion victim by Amin Ahtar, and our kind of cruelty by Ereminta Hall. The list goes on and on. I like reading about bad people doing bad things. The problem here is this is a first person POV from one of the biggest douchebags I've ever come across in literature, and it just, the scares, for the first, I would say 200 pages just weren't enough there for me to care. The book ends up being a weird mishmash of Doctor Who, let's see here, Doctor Who, oddly enough, A Christmas Carol, Charles Dickens, A Christmas Carol, and The Exorcist all rolled into one. That's the best way I can describe it. It's a good, it's a good book. It's an okay book. It's much better in my opinion, well you guys know I don't like it anyway, but Headful of Ghosts by Paul Tremblay, and the reason why it's so much better, I wish this one had gotten more, even though I don't love this one, I'm going to give it three stars. I really wish this one would have gotten more attention and more credit than Tremblay's because he, I think Arnaud does a much better job reinvigorating either the genre, the possession story, the exorcism story, it's just a much better written piece of work. In that it's more entertaining. He uses modern technology and stuff like that in a believable sense. I believe, you know, everything, and one of the things that helped with this is the fact that our main character is a douchebag. I didn't like reading about it. I did not like reading about this particular man. I don't know why, because like I said, I love reading about terrible people doing terrible things, especially if there's some comeuppance at the end. Jack Sparks, well not supposedly, Jack Sparks dies in this book. It's on, it's literally on the, it says Jack Sparks died while writing this book, so it's not a spoiler. It's the whole plot of the story, really. So the book opens up and we find Jack at an exorcism, and the only thing I'm going to say about that is he laughs. It kind of sets the whole book into motion. He laughs because he thinks it's fake. He starts making, well I don't think he, I don't remember that he starts making fun of it, but that's really where the book starts. Pretty much the rest of the book revolves around him trying to disprove the supernatural after basically seeing something that had to have been supernatural. I guess it didn't have to, but in this one there's a lot of BS from this dude trying to convince himself that there isn't supernatural stuff going on, and that got old and tiring. The repetition of him just denying stuff that couldn't possibly be anything else. The him coming up with these elaborate leaps of logic, as an atheist myself, the character is atheist, as an atheist myself, I've never been that adamant about disbelieving. I would love to find some kind of special, other world, some supernatural, whatever. I'd love to find out having it real or whatever it may be, but up until that point logically I can't agree with that. But this character seems like one of those militant atheists, and I don't care too much for that, and I don't care too much for the idea toward the end feels like all atheists are closed minded. There was the message there at the end. I thought that was odd. It seemed to really harp on that toward the end, especially when I guess he couldn't see past himself, which is kind of my feelings on religion. People who believe in religion refuse to see facts. This character refusing to see facts, even as an atheist, that just felt like an odd, not odd, but it felt like contradictory there. And I guess that was one of the things, they're trying to make him hypocrite, trying to make, not there, but Jason Arnaub is trying to make him as bad as possible. So do I think that it was author intrusion? I don't think so, but it seemed like in the book it focused on that aspect. Not too much, it just seemed like it focused on that, and I didn't care too much for it. I don't think that the character was portrayed well enough, even given his backstory. I hope all that stuff makes sense. I almost quit this around page 200 or so, I think that's when it was because someone out there told me that he dies halfway through the book and then his brother comes on and tells the rest of the story. I don't know who you are, but you lied to me. And I was expecting that, so I'm sitting there the whole time, I got my hopes up, and I started hating the book because of that.  I want this dude to die, and then it seemed like they were going to go down this redemption arc for him, and that also got me the point, I don't want to read this. This isn't the book I signed up for. And then there came this huge 30, 40 page scene of utter brilliance. It didn't really turn around the whole book for me, I'm still only giving it 3 stars. But it certainly jacked it up from a 1 all the way to a 3, 3.5 stars. If it wasn't for the repetition of twists, at the end I don't know what the deal is with every single book coming out nowadays having to have 4 or 5 different twists instead of just one big kick in the stomach, or two kicks in the stomach. This one just seemed like it just went on with, oh yeah, by the way, the explanation for this is a twist also, and it's gotten to the point where I was like, you know, the magician has pulled the sheet off of the reveal too many times so far. And that kind of ruined the ending for me. Another thing is the book kind of doesn't know what it wants to be. I don't want to give any spoilers away, but it tries to be one thing and tries to be another thing and tries to be another thing without really narrowing down what it actually is.  He's like, it could be, but it also couldn't be. But it could be, but it also couldn't be. At the end of that book just kind of jumps back and forth.  It's not this, it's actually this, but it's not actually this, it's this. And this book didn't really do that. It didn't continuously disprove what was there before, but there were so many threads in the story that he had to tie up, that it, ah my nose, I'm sorry guys, that he, it's like he was jumping through hoops trying to fix everything at the end. Now is the book worth those 40 pages, there's some more stuff in there also. There's one with a shower drain scene that I think was especially epic. But is the book worth those first 200 pages where I just completely despise the dude all the way up to the end? Nothing about that changed. But is it worth kind of torturing yourself to read about this guy? I'm leaning toward yes. I didn't like the book. If you read, let's see here, Sadie's or Mother Horror's review on Goodreads, she gave it four stars, but she fully admits she had the same problems I did with it. Steph over at, that's what, Stephanie over at, that's what she read. Even that review is just four stars and they both say they love the book, but it's both still four star reviews, so there, they see that there's problems with the book. Maybe not problems, but parts that they didn't, you know, entirely love, and I respect that by the way. Maybe who can look at something that they really liked and find problems with it. I really, really respect that. But with this book, I would recommend it just because it does what Head Full of Ghost didn't for me, which was take a exorcism story and do something new with it instead of just rebooting, you know, not William Friedkin, who wrote Blatty, whatever his full name is. Friedkin did the movie, right? But anyways, he, this, well, not this, Jason Arnott did, I feel, what Tremblay failed wholeheartedly at, which was making this believable and actually committing to an idea to, not really a theme, but committing to the story well enough that he's like, I'm going to give you some real horror and try to disturb you. And this actually did it, whereas in the other one, there was so much left open and so much was vague, and then so much that felt like it didn't need to be there. I do think that Arnott did a better job, but I'm sure there's plenty of you guys that are going to disagree with me, and I'd love to hear from you down there in the doobly-doo. If you liked it, let me know why you liked it. If you disliked it, let me know exactly why you disliked it. But until next time, I have been E, you have been U. This has been another book review, and yes, at 3 o'clock in the morning, I'm exhausted, but I'm trying to get this done, so if I'm not as perky as I usually am, I apologize. I'll talk to you guys later. Bye-bye!


I suppose we should get started since it's now 8 o'clock. I'm going to introduce Michael Varner. He's a professor of maternal fetal medicine here at the University of Utah. And he's also the director of the Center for Personalized Health Care here. He's been the director of that for about a year. And his other claim to fame is that he's been married to Kathleen DeGreece for 37 years, to the extent that his daughters are intelligent and good-looking and prove that she's their mother. So when I was asked to give this talk, I thought, I'm going to go read the ophthalmologic literature, and I'm going to make this an ophthalmology-specific talk. And that didn't happen, actually. So if you're expecting that, then I'll apologize up front. But I have found myself on a steep learning curve over the last year with this whole project. And I thought it was a good idea to let you all know what's going on. And frankly, my thinly veiled motive is to try to engage the Department of Ophthalmology in this project, which it really hasn't been up to this point. So the first quiz question is this. What was the Carnegie Foundation's bulletin number four? And if I can make a Socratic response to that, it's what's now called the Flexner Report. And all of us basically in this room have been affected profoundly by that. It was really what introduced science into medicine, what some people might call the first revolution in medicine or medical education. They say people know about these things say that human knowledge doubles every 18 to 24 months, which, if that's really true, turns out that's not a straight line increase. It's an exponential increase. And we're now into something called the Zetabytes worth of knowledge. And I'm not quite sure how many billion billion that is, but it's a lot of information that we're accumulating on a year-to-year basis. And certainly in our business, all of our business in medicine, this ongoing, if you will, explosion combined with costs, which we'll talk about in a second as well, has really gotten to the point where we ought to be thinking about, people are thinking about, if you will, a second revolution. So in 1910, the state of the art was germ theory, chemistry, physiology, pathology, physics. And what we're trying to do in those days is understand disease, find it, fix it. And that's still the fundamental tenet of medical education. And by and large, of medical practice today. Nowadays, though, we've got all these other things, genomics, the omics, if you will, systems, biology, informatics, et cetera. And hopefully, the name of the game going forward is going to be predicted and personalized. I think I hope this is about as close to, oh my god, slide as I have. But historically, at least, we've kind of been over in this range of this curve. Where we can first detect something, where we first intervene. And the disease burden tends and costs both tend to be pretty high. And the theory, at least, is that we ought to try to shift towards, if you will, at least the earliest molecular detection, if not even back as far as trying to alter the initiating events. So people say, well, what is personalized self-care? And I've heard it said, well, it's kind of like pornography that I can't define it, but I'll know it when I see it. And I don't know if that's really true, but Jennifer Logan, who is my co-compadre in this project, and I have opted for this particular definition, the tailoring of medical treatment to the individual characteristics of each patient. Now, a lot of people think of personalized health care as being equivalent to genomic medicine. It is certainly, genomic medicine is certainly part of it, but it really has to be more than that. In essence, though, trying to provide the right intervention for the right patient at the right time and at the right cost. And my ventures to this side of the bridge, by and large, are bringing my wife lattes on neuro-optimology days. So I don't really know much of the day-to-day, I don't know anything about the day-to-day operations over here, but on the other side of the bridge, historically at least, cost has been a four-letter word in medical education and medical practice both. And I have been hurling myself on a sharp stick for a long time trying to find out how much anything costs, in at least around the University of Utah. It's a very closely kept secret and we need to come out on that. You may hear people talk about something called P4 medicine, which is a nice acronym that predictive, personalized and participatory. And this participatory thing, I think is particularly important and something that needs to be kept in mind when we're tempted to think about it as just genomic medicine.  So the history of this around the University, the abbreviated version hopefully, is that those of you who are here, 2007, 2008, the institution spent a year with having a research strategic planning process to try to develop a plan for the next decade. The two things that kept bubbling to the top were molecular medicine and personalized healthcare. What the management chose to try to do is to recruit somebody to come in, help us set it up right. The number of people out there in this particular arena turns out to be pretty small, very small. And what happened basically is they had two people who had a pretty good job where they were come for several interviews, kinda get up to the 11th hour and then back out. And so I think what we ended up with was two people who had pretty good jobs where they were ended up with better jobs where they were and we ended up with nothing to show for it for two years. So I got a call to the principal's office back in about February of last year. And I'm happy to say I don't get called to the principal's office very often, but Dr. Betz made me an offer I couldn't refuse in terms of what I serve as a interim director for this project. So as of May 1st last year, I've been involved with this. And for the current fiscal year at least, we've had five program objectives which I'll zip through momentarily though, a lot of which it turns out overlap with the CCTS. And so we've had a collaborative agreement with them from the beginning. One thing I wanna tell you a little bit about was an online forum and a strategic planning retreat that we had last fall. And then also a little bit about a white paper that I was hoping would have been posted for general comments by now, but I haven't quite made it. So the objectives are basically these and it's really pretty much the usual suspects, but we had a grant, when we set this up for last year, we actually had several hundred thousand dollars on a one time deal both for pilot projects and for a genome exome sequencing. And at the moment we have 154 exomes in the process of being sequenced on six different conditions. And hopefully we'll score something big out of that. We've been, the program has been a supporter of the UPDV and I know that several of you have been involved with that but I wanna say a little bit about that in a minute. And then also something called the Utah BioHealth Initiative. This is a collaborative venture between the university and Intermountain to try to basically to figure out who's got what in terms of biologic samples. One of the advantages of working in a bottoms up economy like turns out we all do is that if you're paying your way you can pretty much do whatever you want. And that's the good news. The bad news is that everybody's pretty much doing what they want and there's not a whole lot of coordination. I mean I have my freezer farm. I'm sure there's some, I know there are some number of freezer farms in this department too where people have snippets of this or that. I bet I have, I bet I have, I don't know, pick a number, 50, 100 snippets of people that I've accumulated over the years who've also found their way into one of your biologic sample banks and there is no way as it currently stands that any of us would know anything about that, let alone who might have something over at Intermountain. Excuse me, from the standpoint of a clinical prospect, this is gonna be a longer haul but we're trying to, one of the things we're trying to promote is clinical pathways, clinical guidance teams, et cetera, interdisciplinary, that's supposed to be collaboration. I thought I'd found all the typos but I guess I didn't. And if any of you have spent any time in the Intermountain system, that looks an awful lot like Intermountain and that's frankly by design. If we wanna individualize things, turns out right now the bandwidth of who does what, where at least on the other side of the bridge anyway is so wide that you really can't tell where normal ends and abnormal begins. And so trying to decrease bandwidth on clinical practice is a, it turns out to be a very important issue, particularly with capitation around the corner, trying to figure out the hot spotting issues. You know again, the top 5% of people consuming an inordinate amount of resources. Clinical pharmacogenetics I know is an issue in every discipline of medicine and turns out those polymorphisms that affect my business, affect your business and we need to come up with a mechanism to track that. And then finally the whole issue of individual and community engagement because we're not gonna end the cost curve just by ourselves. We have an education advisory committee and we actually have a spring semester course on personalized healthcare that's being run through the K30 program. Hopefully it'll be more widely advertised, subscribed. We're working on curriculum offerings for the fall and also for a certificate program. And I don't know, have any of you heard of our personalized healthcare discussion groups that meet second and fourth Mondays at 515 over in the Williams building? Williams building is over in Research Park. It is by definition off campus and so one can have pizza and adult beverages at 515 on Monday if that's an attraction to anybody. We had a travel grants, happy travel grants program where we pay for some number of people this year to go to personalized healthcare meetings and we hope it'll sort of jumpstart some interest and we're planning to do that again next year. We have another program coming up that may or may not appeal to folks here but personalized healthcare and women and children's health in May and we're planning several more for this upcoming year. Probably in September to have a couple of day session about the UPDB. This year is the 30th anniversary of the executive order to set the UPDB up and so we hope we can not only open the gates a little bit wider but also have some sort of a fest drift about what's been accomplished to this point. We'd like to think of ourselves, Jennifer and I anyway, as a sort of a communications or information hub for the institution. We've been around to talk to an awful lot of people, 150 plus anyway, around the university, Intermountain, the community at large about what they think personalized healthcare is or could be presentations like this. Et cetera and again we hope we can be a information hub and the communications center. I mentioned the CCTS and again we have a lot of things of areas in common. We've had the CCTS review our grant submissions, the course that we talked about and at least one more coming up. You know on my computer screen Vivian Lee doesn't look nearly as pixelated as she does there but everybody knows that she arrived in July and one of the things that she, several things she keeps talking about, bending the cost care, personalized healthcare, increased collaboration with Intermountain. And when she was the dean for research at NYU she set up a program where sort of a web blog where everybody in the place could either list or comment on somebody else's listed topics for research ideas and people ended up sort of populating themselves into groups, working groups and it was very successful there. And she suggested so to speak and you know when the dean suggests it's always a good idea to listen that we do the same sort of thing here which we did and it was really quite remarkable. We had ended up with 82 topic areas, 450 some people offered comments and sort of more or less distilled to these same issues here. The one of the people at Ski at the Super Computing Institute has a little program that will scan through a word document and then list all the words, the size being the reflection of how frequently they're mentioned treatment, risk, information, genetics, the usual again suspects there but we had this retreat back at the beginning of December, end of last year. And so one thing I learned from this is that the term strategic planning retreat and the number 277 actually don't go together all that well. It's pretty hard to get granular with that that many people, we had attendees from a wide number of areas, all the health sciences colleges, a fair amount actually of the university and a number of cultural business communities. The one thing, two things that were notably missing here. One was the payer community and the other was the department of ophthalmology. So who was the only ophthalmology representative and it was kind of given away already, it was my wife and she was there because I made her be there to give one of the talks. And so I am hoping that if nothing else out of this hour that be successful in engaging you all in this project going forward.  And we ended up with these focus groups, there were nine of them all together looking at these topics and then each group gave a report that afternoon. But probably the thing that was most impressive to me out of the whole thing was the number of connections that were clearly established between people who were two floors down or up from somebody else or in the next building over who'd been here for however long and never knew that somebody else was either here or had any idea of what they might have been doing. So again, if nothing else, we hope we can help facilitate collaboration and communication on these issues. This white paper, again, I'd hoped it'd be out by now, but it was a summary of this whole process. And we'd like to think it's gonna take things pretty much down to the ground, but I'm gonna spend the rest of my time just kind of going through some of these priorities that came out of it, UPDD access, family history, pharmacogenomics, the consolidation of research databases, issues of health economics, comparative effectiveness, research, et cetera, point of care education, and then a little bit about multidisciplinary and specialty pathways in education. So if nothing else, this slide is gonna show up a few more times in the next few minutes, so it'll give you some idea of how much more of me you've had to listen to. I mentioned the UPDB, and again, it's been around for 30 years. There was a time, 10 years ago, where people could say, well, the UPDB and Iceland, and perhaps Sweden and Norway had the best genetic epidemiology resources in the world. And it turns out that, between Iceland imploding and relatively more effort being put into the UPDB, it really does seem as though we've gotten to the point of it being the biggest, the best genetic epidemiology resource on the planet. It's governed by something called the Resource for Genetic Epidemiology, which is a confederation of the major players in this, the university, the church, and the health department, Intermountain more recently has a seat at the table, and they, to their credit, keep a careful watch over all of their data. And to this point, at least, have not had a security breach, which is something that they're planning to maintain. But it's a really remarkable resource for looking at a whole lot of different things. And again, I know some of you all have been involved with it, and to the extent that conditions you all deal with could be intergenerational, to the extent that they can be cosegregated with other conditions. It really is a unique resource. It's not free, on the other hand. They will, if you're working towards a grant, perform at least a limited number of hours of work to try to gather preliminary data. Other than that, though, it ends up being a fee for service exercise. If you can collect your own data, or if you can analyze your own data, and they just provide it to you, it ends up being pretty economical. If they're gonna analyze it for you as well, it starts to get a little pricey.  This is a slide that I got from Randy Burt over at HCI, just looking at a family pedigree for colon cancer and colon polyps. And again, can look at all sorts of different things. Family history is another important thing that we wanna try to emphasize. And people say that genetics is family histories, or family histories with data, which I think is probably true. And the flip side of that, of course, is that most of the family histories that any of us in clinical medicine collect are not worth the paper they're printed on, because we only get, if we actually ask people in detail, we only get what they know, which is more often than not incomplete at best and with some regularity, not only incomplete, but inaccurate. So again, they're only as good as the questions that are asked and the information that is known. On the other hand, with current informatics technologies, all of us, at least who are engaged with a healthcare provider, have a problem list someplace. And I would contend that we can and perhaps even have an ethical obligation to have to do better than what we do. And that's, again, because we need these family histories to be able to utilize computerized decision support, which is something I'll talk about in a minute. Again, identify co-segregating diseases of all sorts. What would it take? Well, one is an appeal to families, which is something that probably sell better in Utah than a lot of other places. But if we're constructing a family history, an accurate family history, a complete family history, well, we're not only doing a service to ourself, but to our families in the future. On the other, HIPAA, which is actually HIPAA, that actually stands for how is it possible to accomplish anything, is a real issue in this sort of thing and we're gonna have to have people presumably opt in for sharing their PHI with other people and their families.  Or I don't want everybody to know that I'm HIV positive. So it'll be a big project, but it is certainly something that needs to be considered. And it needs to be a community-wide effort because if I get my healthcare at the university, but my sister gets her healthcare at Intermountain, well, then what good is that? We're not any better off than, even if we use my problem list, we're not any better off than where we were before. So again, no one health system is gonna be able to do this alone, but only by having all this information, accurate and complete information, can any family history tool ever be functional. Long-term personal histories are also important. I mean, not only from generation to generation, but long-term for me. I mean, what do the things that I am dealing with now portend for me in the future? One example, I don't know if it's Greg here. I don't see Greg. Anyway, Greg Hageman and I have had some conversations over the last year or two about this issue of co-segregation that women who have preeclampsia, it seems, which is something I deal with are, would seem to be more likely to show up with the macular degeneration 50 years later at your place. Any number of environmental exposures, gene environment, I mean, 25 years of living here, I still don't think it's right to see the air that you breathe. And Lisa, again, and I'm sure there are ophthalmologic effects of that. Premature labor is something that I deal with that comes and goes in relation to air pollution. And then finally, there's this whole issue of systems biology that the day, a lot of us got a lot of papers written about associations with this or that, SNP, et cetera, but it turns out that it's a lot more complicated than that and we're gonna need long-term personal histories, family histories to really sort the true complicated nature of biology out. So pharmacogenomics. All of us know that one size, the adage of one size fits all either in terms of diagnosis or treatment just doesn't hold water. One of the sort of the big, well, first off, oncology has been very much a poster child for pharmacogenomics in the past decade anyway. And that really got tipped off with this stuff called Herceptin, which is a medication that is very effective in women who have a specific protein on their breast cancer cells. And if you're unfortunate enough to have breast cancer and likewise don't have this particular protein, this stuff doesn't work really at all. So this has been sort of the poster child for this whole idea over the last decade. And it's brought up to this point has become a very big deal in Pharma's world, which is companion diagnostic testing, which is, in fact, the FDA just had a ruling back in July, the essence of which was that if you have a medication and evidence that there is a genomic marker that will identify who will or won't respond or who will or won't have adverse drug reactions that you're obliged to have that test run in association or at least prior to administering your medication. In oncology, there was a paper a few weeks ago now that just looked at SNP composition of tumors biopsied from several places at the same time. And the idea that a tumor was homogeneous kind of got shot out of the water at that point. Likewise, tumors develop resistance just like bacteria do. So this is gonna be an ongoing game of whack-a-mole, I think, but it's important to keep in mind for all these new things. A lot of different drugs that, again, we all use for different things and all of which have substantial rates of poor response, et cetera. The theory, at least, is this, that if we have some number of people with whatever diagnosis, that there'll be a group who either don't respond or who have adverse reactions and then we ought to treat them with something else. And then there's the rest of us who in fact should be treated with the appropriate medication. Adverse drug reactions is something that turns out to be a big deal. And I actually, I don't know how much of an issue it is for you all, but across the board, 5% of all hospitalizations are a result of adverse drug reactions. One in every 10 patients will experience one. 700,000 injuries, deaths per year, estimated approaching 100,000 deaths per year from adverse drug reactions. And you're in and you're out for the last 15 years since people have been keeping track of these things somewhere between the fourth and sixth most common cause of death in hospitalized patients and adverse drug reactions, it turns out costs more than the drugs themselves. So it's a lot of money. It's not easy to sort out because there's all these different cytochrome P450 things and a bunch of other different enzymes, et cetera. And in the world of ophthalmology, are there any of these that, I don't know if there are any of these that jump out in particular, but one of the things that we'd like to try to accomplish is to get us to the point where we can share information across disciplines about where the hotspots are, what the drugs adverse drug event issues are. A lot of challenges though, and it's easy to stand up here and talk about it. There's a lot of studies out there. Many of them are inconclusive. And it turns out that it's not just as simple as genetics that there's any number of other issues that go into explaining the variability for a given drug, some of which we know and some of which we don't. And frankly, when you get right down to it, very few studies still at this point that documented genotype-guided therapy is better than, if you will, the usual care approach of just trying to figure out as we go. One reason for that is that there really aren't very many point of care tests available. It's easy to say, well, we're gonna check this or that, but the reality is, if you have to draw a tube of blood and it goes over to Arup and it comes back two days later with this or that report, you've already ended up deciding what you're gonna do and it's gonna be something in hundreds of dollars anyway. So I have no financial interest at all in a company called DNA Electronics, but we're in the course of talking to these folks about a collaborative effort here and what they've come up with is a little device that you can spit into one end of it. You put the cap on first and then you mix it up and basically is some number of proteinases, RNA, et cetera. The other end of it has a USB attachment on it. You put it in your computer and in 15 minutes or so, it'll give you a report out of whatever steps you might want to program the chip for. Basically, collect the sample, slosh it around, put it in the computer and it puts out your whatever results you might want. I think at least, I mean we'll see, but it seems like it has the potential anyway to be a game changer because you can get results back in 15 minutes. You cut the lab out of it all together and so there's a substantial decrease in costs and it may well actually be a technology that's gonna tip us over the edge on this pharmacogenomics issue in the next couple of years. So stay tuned for that. Consolidating research databases, basically I think I talked about that a couple minutes ago, but again, if we're really gonna get to the bottom of some of these issues in a truly personalized and comprehensive fashion, we just have to be able to talk better, we have to be able to talk amongst ourselves about who's got what and where it is and how it correlates with. Likewise, in terms of health economics comparative effect in this research, people talk a lot, well we're all talking about bending the cost curve. One cost curve that actually has been bent is the cost per genome and this is just sequencing, but again, it was 1999, which is back here, was $3 billion for the Human Genome Project coming along here. We're down now to the range of a few thousand dollars. People are talking about the $100 genome. What they don't talk about is how to make sense out of all of that, but there's some rather substantial progress being made in terms of trying to actually at least look for causative genes for various conditions and pedigrees. The idea of the whole genome, here's my genome, what do you think Doc, is a little further out there because all of us have, and each one of us has some hundreds of thousands of copy number variants, indels, all these different variants of unknown significance that we just really can't make sense out of yet, but certainly the cost of the analysis anyway is decreasing.  And these are the five largest national economies in the world at present, measured in trillions of dollars, which are thousands of billions, and it turns out that the U.S. healthcare system is the fifth largest economy in the world. A third of that is just waste or inappropriate treatment, but even if we knock that out, we'd still be the eighth largest economy in the world. And I don't think to say that that's just not a sustainable proposition. One of the other things in the program, personalized healthcare that we're trying to work on is point of care education. Just as an example, this is a program that actually the informatics folks here have put together, looking at warfarin pharmacogenomics and trying to come up with a point of care program that would help decide loading and maintenance doses. So it would come up, if we knew their SNPs already, come up and say, well, this particular person here might have an increased risk of bleeding complications and that they would need to either adjust the dose, monitor things, and so what do you want to do? You want to cancel that, modify drug doses, whatever.  And it comes out with a warfarin dose. And again, one place where this actually works pretty well right now at least is elected joint replacement of the people over at the Orthopedics Hospital who are actually doing this a fair amount. They have the luxury of being able to send this off on somebody a week before their surgery. If you show up with a acute PE in the emergency room, we'll send it off as you can still do it, but it's not going to be at this point at least not as helpful. So it comes out with an estimated dose, a loading dose, could say, well, here's how much you need for today. Are you taking any of these other medications that might impact the genotypes if you've been on it for a while? But the point being out of all of this that it has at least the potential not only to educate us and our patients, but also to try to minimize prescribing errors. Computerized decision support is clearly on the way here. All of us are being, will be obliged to utilize this technology with the inpatient and outpatient records. A lot of different things that it can potentially do. Alerts, reminders, remind us of clinical guidelines, pre-specified order sets, et cetera. Again, diagnostic support and point of care education. Patient education is clearly going to be an important issue too. Not everybody out there realizes or understands how much this whole system actually costs. In terms of getting timely results back at least, there's a educational opportunity there that patients can understand how it is that their therapies are being individualized that they can see the consequences. And for some things, could potentially get results confidentially. The issue, one of the things that's clearly going to be coming up more in the next year around the institution is the idea of some form of multidisciplinary pathways. And to be perfectly honest with you, I'm not exactly sure what form that's going to take. Dean Lee, the He-Lee, not the She-Lee, is very interested in looking at clinical pathways from the standpoint of drug diagnostics device developments. Jennifer and I are somewhat more interested in looking at multidisciplinary approaches to common diseases and problems. Pretty much every clinical entity, clinical department deals with diabetes, but we all deal with diabetes in our own separate way. We don't necessarily know what the guy in the next clinic down the hall or across the bridge might be doing. And so from an educational standpoint, that's going to be an important issue. And then the last thing to talk about is education. Josh Schiffman, who's a pediatric oncologist, is serving as our education committee chair. I mentioned we have this course going on this spring. We'll be offering again next spring. We're working on a certificate program and, again, the pizza and adult beverage discussion group will be starting up in May. I think the first one is May 14th. And again, we're trying to get out and talk to folks about this issue. It is important. It is pretty clearly the way forward. It's Vivian Lee's idea of the way forward. And so we need to at least know what's coming. So from our perspective at least, we think personalized health care is going to involve a paradigm shift towards individualized care that we hope will maximize health and minimize both morbidity and unnecessary costs. We think it's more than genomic medicine needs to be more than genomic medicine. And that it's going to represent a commitment not only by the entire Health Sciences Center, but the Utah community at large and for that matter, the country. And one of our sort of mantras in this whole thing is that we are actually now all in it together in the days of individualized silos, if you will, not only in terms of research, but clinical practice, really need to be reconsidered. So, anyway, this is my contact information. Jennifer Logan is my partner in crime and Connie Barth is the person who really keeps the wheels on things. We have a list serve for these discussion groups and other things in terms of upcoming events. If any of you are interested in that, well, the best way to get on it directly is to just send an email to Connie. If you have any questions about any of this stuff, well, please feel free to give me a call or send me an email anytime and I'm happy to talk about this for I bet longer than any of you would care to listen. So, thank you for your attention for letting me come and I'll be happy to answer any questions. Stunned silence. At any rate, thank you.


The study estimates that between 2010 and 2030, communication technology, CT, will consume up to 51% of global electricity, with the proportion of use-stage electricity by consumer devices decreasing and being transferred to networks and data centers. However, renewable electricity is expected to exceed the demand of all networks and data centers until 2030. The analysis suggests that CT could contribute up to 23% of globally released greenhouse gas emissions in 2030. This article was authored by Anders S. G. Andre and Tomas Edler.


Ladies and gentlemen the story you are about to hear is true. The names have been changed to protect the innocent Dragnet is brought to you by Chesterfield made by Liggett and Myers First major tobacco company to give you a complete line of quality cigarettes Your detective sergeant you're assigned a robbery detail a gang of truck hijackers has been working in your city They've stolen 14 loaded trucks They've kidnapped and beaten one of the drivers. There's no clue to their identity your job get them With the winter season coming on young America and all of us will be concentrating on our favorite winter sports Ice skating bowling basketball ski One thing you'll notice whatever young America does wherever it goes Chesterfield goes along Yes, Chesterfield is the choice of young America Chesterfield is the choice of more thousands of smokers everywhere People are learning the facts about Chesterfield Learning that Chesterfield is highest in quality low in nicotine Learning that Chesterfield is really mild Really satisfied How about it friends change to Chesterfield yourself? Smoke America's most popular two-way cigarette regular and king-sized Chesterfield Best for you Dragnet the documented drama of an actual crime For the next 30 minutes in cooperation with the Los Angeles police department You will travel step-by-step on the side of the law through an actual case transcribed from official police files From beginning to end from crime to punishment Dragnet is the story of your police force in action It was Wednesday June 4th was warm in Los Angeles We were working the day watch out a robbery detail my partners Frank Smith the boss achieve a detective stad Brown My name's Friday. We were on the way out from the office. It was 947 a.m. We got to the county hospital Ward 419 Mr. Gilmore. Yeah, I know you guys. No, sir. We're police officers. This is my partner Frank Smith. My name's Friday I just a couple stools over there drag him up sit down. I'll get him Here you go. Thanks How do you feel Mr. Gilmore rough real rough feel like I've ridden 50 miles in the back of a ready-mix cement truck Weren't for the pills it be given me. I think I'd go out my rocker You won't tell us what happened. Yeah, as much as I can remember Only goes so far then there's a room full of black if you'll tell us what you can please. Yeah Yesterday that's when it was yes yesterday morning. I checked in for work had a load I was going to take over to phoenix supposed to shut off about 10 10 15. Did you know what you were carrying? Yeah, I saw the way bill Some of the stuff they were loading it Used furniture didn't make any difference to me. They load the truck and I'll drive it I want to cross the street little coffee place over there and got my back and bottle filled and came back By that time they had the truck loaded I signed the way bill on the office and went out and got into the truck the two guys were waiting for me They were in the cab of the truck. Yeah, I'm sitting there kind of scrunched down so you couldn't even see it from the outside Soon as I opened the door one of them had a gun pointed at me told me to get into the truck like there was nothing wrong Just start the motor and get the truck away from me. Did they get out of the truck at that time? No, no, they were waiting for me when I got there.  By Porter Street between Porter and Enterprise. I see like to go ahead Then they told me to pull into the alley and When I did they made me get out of the truck took me around back and broke the seal and told me to get inside And that's what you did Officer if they had told me to jump off the city hall out of gun I hadn't done it with that gun pointed at me.  Yes Those guys remain you could tell. How's that? Oh, I'm a kind of a student of phonology I could tell about those fellas real plane Student of what?  I could tell I had a bumper right here Yeah, you see yeah, he's mean to his mother Yes, you well what happened after they tied you up just left me there. I see you want to go on yeah They must have drove for about 20 minutes when they stopped pulled in some sort of a driveway I figured that well right after they stopped they made a half you turn them backed up backed up this ramp steep And they stopped and took me out of the truck blindfolded me and made me get out of the truck Now this place where they stopped that's where they unloaded the furniture. Did they yeah, I must have taken it out Of there heard them something around the truck sound like they're unloading it Well now what they do after they got all the furniture out put me back in drove out to where you found the truck after the Both climbed into the back beat me up. Don't remember much after that Both of them worked you over huh? Yeah, both of them got in their licks especially the one who was mean to his mother He was vicious mean they kept hitting me with their fist until I just passed out Don't remember anything after that till I came to in the back of the truck That's when I call the cops and the guys in uniform came out.  Yes, sir Well, I think maybe I got an idea I tried to figure out how fast they was driving and after you've been a driver for a while you get to know I'd say they were going about 20 miles an hour. We were still in town. My own guess is that they went out Alameda Must have gone outside of favor and then turned on the Alameda Remember here in kids yelling Probably be Santa Fe high school. Yeah, I guess we went out Alameda to maybe 43rd or 44th and they turned right kind of hard to figure it then the truck got tied up and traffic It was hard to tell if they were stopping for that or they're just a delight But I'd say that they went out to about Avalon. Yeah, maybe they went up to San Pedro. I don't think so I'd say Abelon then they turned left and headed for Hawthorne. I'm not sure how far they went But I figure maybe around Rosa Cranes and then they turned a couple more times and they stopped and drove up that steep ramp Mm-hmm. Now you figure they ended up around Rose Cranes and Avalon. Yeah Guess that's not much help though. Well, it gives us an idea where to start looking a couple other things that might help you What's that? Well, it seems that when we started to back up the ramp I heard a bump like they're backed into a car. They didn't hit it hard, but I bet they did hit a car Yeah After that they pulled the truck forward and stopped and backed up again this time. They scraped into the side of a house I could feel it run along the side of the truck Sound like they might have torn up some of the wood on the house. Yeah Will that help any? Yeah, sir We'll have our crime lab check the truck and see if they can come up with anything. Sure. Hope you can Oh You talked to my boss yet. No, sir, but he's been notified. We understand that he's plenty sore about it Well, we wouldn't know about that, but he should understand that it wasn't your fault. He should but he won't I know that right?  What's that sir? His head all kinds of bumps 1006 a.m. We continued to question the victim Russell Gilmore He gave us descriptions of the two men who kidnapped him He also told us that at one time he heard one of the men call the other by the name Leo Further he told us that when the two bandits had taken him from the truck they placed him in a garage He was able to feel the wall. He said that he was sure it was a plaster wall and as much as he could feel the studs and the wire holding the plaster He said that at one time he heard a woman come out of a house and say something to the thieves while they unloaded the truck He told us that the garage wasn't very large because there was no echo on the sounds that were made in the building We called the office and got out a supplementary broadcast on the thieves carrying their descriptions 1040 a.m. Frank and I left the county hospital and drove over to central station We went up the crime lab and talked to Ray Pinker on the right rear fender. We found evidence of the truck had hit a car Lifted some paint chips Looks like a blue car, huh? Yeah I checked the paint with a ditch of production color book here. I'll show you You got all the paints cataloged by color Here This is the one Yeah, but Ray, there are a lot of blues there. How can you be sure this is it? We're here.  Mm-hmm. We just put this chip we lift it from the truck in the hole Now let down Get this lamp There color matches get in the same light you can see the same paint. Huh, look at that Joe same. Yeah, see Well, what do we got out of it, Ray car the truck hit was a 1953 Hudson jet There's a single tone car, you know the top color matches the body color. Yeah, you only use this on one color cars Unless you got a special order. Mm-hmm. Did you find any house paint on the side of the truck? Yeah over here Might be able to do a little better on that for you. Mm-hmm house truck ran who's about 36 years old Might be a little more than that, but it's right around there How could you come up with that been painted 18 times figure once every two years you come out with 36 Yeah, how we know it's been painted every two years We don't Francis guessing but the layers of painted pretty even might indicate they did it regularly You know didn't let the faint go too far for they redid it. Oh, yeah Here are the chips of the house paint here. I put one up under the microscope Gonna take a look Joe. Okay You see, okay Notice the first coat was a cream white Mm-hmm, and they stuck pretty much to that for the next half dozen paint jobs and they changed to a barn red Into a green then back to cream white That goes on for three layers and then to the blue that's on it now Yeah, we're a if we find the house. Can you tell us if it's the same one? Shouldn't be too hard aren't many of them around the harmony Well, 18 coats would be 18 factorial. That's multiplying 18 times 17 times 16 times 15 So on the times one I got it worked out for you. I hope you have I'm not with you at all here Well, look works out to one and six quadrillion four hundred and two trillion three hundred and seventy three billion seven hundred and five million seven hundred and twenty eight thousand chances of finding its twin It's pretty long odds Well, if every man woman and child on the face of the earth own ten houses a piece there wouldn't be another one like it 1137 a.m. We put in a call to Layton Prince Harlan Stahl told us that his crew had gone over the truck thoroughly But it failed to come up with anything We contacted the stats office and asked them to make a run on the MO that the thieves had used They told us that the results would be ready for us late in the afternoon We contacted hit-and-run detail, but there'd been no report that could have been the car that the truck had hit We went to the office and got a large map of the city Then we drove out to the county hospital to talk to the victim again We asked him to trace his movements while he'd been held prisoner in the back of the truck He drew a line down Santa Fe Avenue up to Alameda then over to Avalon Boulevard on 43rd Street From there he traced the streets down to Rose Cranes Avenue He drew a circle on the map centered on the intersection of Rose Cranes Avenue and Avalon Boulevard He told us that we'd find the house we were looking for inside the circle Before we left him we made arrangements for the mug shots to be taken to the hospital for him to check for a possible identification of the suspects 1240 p.m. We contacted records and identification division and asked them if they'd had any luck on running the name Leo We were told that they had three possibles for us the addresses on the packages were not in the area that had been circled by the victim Russell Gilmore We got in touch with Lieutenant Jack Smires and filled him in on the developments He called Metro Division and made arrangements for three additional teams of men to work with us in a search of the streets within the circle drawn by the victim He also contacted the divisional commanders and asked for their cooperation The men were instructed to find a residence with a steep driveway leading to a detached garage The house would have a wooden porch on the right side of the house as it faced the street It would be damaged to the wood on the porch Also, there was a possibility that a Hudson automobile would be parked either in the driveway or on the street right next to it The car would have some damage done to it 515 p.m. Frank and I got back to the office from the search area. I'm sure tired. I'm with you a lot of streets out there Yeah, a lot of houses on the streets. What are other guys from Metro doing? I got it robbery Friday Yeah Just a minute. Let me get there Yeah, okay. Hang on to it. We'll be right out right All the Metro boys did some good. Huh the house they found it The address given us on the phone was 1486 Cedar Street down in Compton took us 35 minutes to get out there from the city hall The officers from Metro Division reserves stood by until we got there We found the house located on Cedar between Dwight Street and Tawata Avenue It was a one-story frame building with a stucco garage in the rear of the lot On the left front side of the house was a wooden porch which had been scraped by some large object Several of the pickets in the railing were broken On the street in front of the house next door. We found a 1953 Hudson jet painted a light blue There was a dent in the left rear fender We couldn't tell for certain but the color of the car and the color of the paint on the porch seemed to match the chips That we'd seen in the crime lab While the officers from Metro covered the rear of the building Frank and I rang the front doorbell There was no answer we checked the garage But we found nothing that would tie the house owners in with the robbery kidnapping The interior walls of the garage were rough wooden studs between them We could see chicken wire embedded in plaster The physical description of the house the ramp leading to the garage the garage itself and the car parked on the street Matched in every detail the picture that we've been given by the victim 610 p.m. We got the name Conrad Lewis from the mailbox in front of the house and while the officers from Metro checked it with our office Frank and I went next door to talk with the neighbors Yeah, what if we could talk to you ma'am sure? Who are you? Well, it might be better if we got in off the porch You ain't coming in here unless I know who and what you are for police officers. Oh Yes, ma'am. Here's our identification. Oh Yeah Welcome on in thank you, ma'am. I'm Myrtle Richards. This is my partner sergeant Friday. I'm Frank Smith. Oh, how do you do? How are you, ma'am? You just sit down? I'll turn off the television. Thank you Comedy I've seen it before a couple of times always laugh at him again. No, they're funny It's a great bone to the people of television. This is only 12 inch But I think maybe next year I'll get a bigger one maybe even color. They got it now, you know It's true color. It's beautiful. Yes, ma'am. Of course. I ain't actually seen it myself. I just read about it You know beautiful Oh, I'm great fan. I got it on all day right from the early show to the late late show I understand next week one of them stations gonna start early early shoulder. That'll be nice moment That's ma'am. Sure. I wonder if we could ask you a few questions. My certainty You just go right ahead that car out front does that belong to you the blue one? Yes, ma'am. Yeah, that's mine I just got it a few months ago. That's what you're here about, huh? I beg your pardon about how somebody hit my car Big dent Isn't that what you're here for? No, not exactly. Do you know who hit your car? No, I wish I did if I knew I'd sue him Imagine hitting the car this park right at the curb not leaving a note or something to say who did it Person ran into me must be insured wouldn't cost him nothing all he had to do is leave a card Yes, ma'am. When was the automobile hit yesterday morning? I walked down to the market to do some shopping get some things for dinner pretzels potato chips things to eat While I watched the TV when I got back the dent was there did it while I was gone did it and didn't even leave a card Yes, ma'am. Could you tell us who lives next door to you, please which side the left side over there? Well, that's Lewis's house. Why are you asking about them? How long they live there? Do you know? Yeah, I guess it's been About 10 years they moved in right after Conrad that's mr. Lewis right after he opened up the new store What line of business is he in? Well, he got some kind of a shipping business as deals with different stores all over the state Did you see mr. Lewis yesterday? Yes matter of fact, I did he come over like usual 5 30 usually come over at that time Does it Tuesday 3rd and Saturday? Yeah, you see there's TV show. He likes to see I watch it But his wife don't care for it. She watches something else. So Conrad comes over here He was here last night. You see him during the day at all. No, I didn't you know where they are tonight I'm not sure but I think they went to the movie seems to me. Mrs. Lewis said that her and Conrad was going to a show Over in town. That's probably for us. I'll get him. I'm mad and so Isn't anybody come calling on me this time of night? Oh, it's Anderson Joe. I'll be right back. All right Have you noticed any trucks in the neighborhood lately Mrs. Richards? Oh? Well, I Have to think about that for a minute. Mm-hmm.  Yeah Well, let me see Well, there were some people who just moved into a new house down the street. That was about a month ago that and help Thank you, Mr. Yeah, excuse me, please miss Richard. Yeah, you go right ahead Yeah, Anderson ran the name Conrad Lewis through the files. He's been convicted for armed robbery You are listening to drag knit the authentic story of your police force in action smokers by the thousands are now Changing to Chesterfield because they're learning the facts about Chesterfield Facts like these a doctor has been examining Chesterfield smokers for 20 months almost two full years now We've just received his latest report and it confirms again No adverse effects to the nose throat and sinuses from smoking Chesterfield That's a matter of record and so is this Chesterfield is the only cigarette proved highest in quality low in nicotine Those are the facts about Chesterfield More good reasons why Chesterfield's tastes so good Smoke so much milder How about it friends smoke America's most popular two-way cigarette Chesterfield regular and king size Best for you The record showed that Conrad Lewis had been arrested for suspicion of armed robbery 10 years before he'd been brought to trial Convicted and sent to Sam Quentin. He'd served six years and then he'd been released He was not on parole at the time Frank and I parked our car down the street from Lewis's house And we waited for him to return at 10 57 p.m We saw a dark colored Lincoln sedan turn on to the street and swing into the driveway of the Lewis residence a man and a woman Got out of the car and ended the house Frank and I waited a few minutes, and then we walked up the front door and rang the bell Yeah, you can't read Lewis. Yeah, that's right. Who are you police officers like talk to you sure come on in What's this all about something wrong do you own a truck hmm a truck do you own one? No You're mind telling me what this is all about. Can you account for your time since Monday night? Why can't you look? I don't know what this is all about, and I'm not gonna tell you a thing until you let me know what you want Now what do you want the answers to those two questions? 12 15 a.m. It had been only a little over 48 hours since Russell Gilmore had been kidnapped and beaten and we had a suspect in custody However Lewis refused to admit any complicity in the crime We talked to him for several hours, but he told us nothing He admitted that he'd been arrested before and that he'd served time in San Quentin However, he stuck to his statement that since his release he had done his best to live by the law With the evidence at hand he was booked at the main jail on a charge of suspicion of violation of section 211 PC We obtained the keys to his place of business and Frank, and I went out to check it It was a large wholesale store selling used furniture The search the premises failed to turn up any of the stolen merchandise While Frank went through the stock rooms. I checked the business ledgers Nothing back there either Joe, how'd you do well according to these Lewis does a big shipping business That's what the woman next door told it been making shipments up to Oakland regular books tell what they were yeah right here He's been sending large lots of used stuff to a place on MacArthur Boulevard There's a whole list of it here tables living room sets TV sets better get in touch with the police up there and have them check This place out huh yeah without that stolen property. We're not gonna have a very good case against them You got the address of the place up north.  I don't they don't we might be in trouble. Yeah, the DA's offices level to throw the whole thing out Thursday June 5th 820 a.m We put in a call to captain of inspectors Tony Bolger in Oakland and asked him to check on the recipient of the furniture shipping from Lewis We also gave him as detailed a description of the stolen merchandise as we were able to obtain in the meantime Lewis had been admitted to bail and was released Thursday 1115 p.m. Frank and I got back to the office from checking a lead on one of the suspects who'd driven the truck I got it Robbery Friday. Yeah, yes, it is. All right, Tony Bolger from Oakland. Let's hope we called it. Yeah. Yeah, Tony Yeah What'd he say? Well, that's the way it looked from here. What yeah, right? Okay. Thank you How about it when you talk to the man who bought this stuff? He's clean. How about the merchandise itself? It's all stolen 1120 p.m. We got in touch with lieutenant Smires and filled him in on the new developments after we talked to him We contacted officers max Herman and Ed Benson made arrangements to meet them at the house on Cedar Street It took us less than half an hour to get out to Compton The other officers were there by the time we arrived while they covered the back door Frank and I went up to the front I think he knows it's us Cars in the driveway we know he's in there wait a minute sounds like somebody's coming now. Yeah What are you doing out here? Aren't you guys ever going to get all my back and talk? I got a choice Oh, you haven't let come on in you want to go through the house again. It won't be necessary. Yeah I'm glad of that. What's it about this time same as before maybe you better spell it from we can go that route If that's the way you want it go ahead. I like fairy tale. All right We got a report from the victim who was robbing kidnapped He was able to give us a description of this house of your garage into the whole setup You've been on a spike again. You're seeing we took a sample of the paint from your front porch It matches paint found on a truck that was hijacked a lot of houses Nellie not painted like this one You think you're gonna send me to the joint with a batch of paints gonna help look cop You know I've been the rounds. I've seen enough trouble to know it's rough to get a conviction with circumstantial evidence That's all you've got with me nothing more now. Why don't you go home and I'll just forget you were here tonight We got the plant What we got the plant they moved in on it and then you saw the stolen furniture too is willing to test you know We got your code now. Why not cop out? That's the way it hangs so that's the way All right, I'll get my coat and just point it out. We'll get it for you in the closet never mind Outside he's in his car. Yeah, come on. He's heading down toward rosecrans Better hit the sound right Better not tell any people around to close in on him ambulance the motors in his lap. He's still alive. It looks like it Can you help me here? Yeah? Yeah, I take it easy loose. I'll call the ambulance right take it easy loose. We've sent for a doctor Didn't see this time. I Didn't know a streak didn't go through lousy break Lousy break I'd have made it if I stayed off the street You'd never got me if I'd stayed off the street. I Just turned the car and all of a sudden I was on a dead end afraid you're wrong there, mister. Huh? You've been there a long time Story you have just heard is true The names were changed to protect the innocent on October 14th trial was held in Department 97 superior court of the state of California in and for the county of Los Angeles in a moment the results of that trial Now here is our star Jack Webb. Well here it is the most talked about Christmas gift of the year the Chesterfield Christmas Carton now featured in nearly a million three hundred thousand retail tobacco stores from coast to coast The famous covered bridge has been honored this week by a new Christmas tune the kissing bridge You'll be hearing a lot of it between now and Christmas So give the gift that everybody's talking about America's most popular two-way cigarette regular and king-sized Chesterfield premium quality Chesterfield Best to give best to get for Christmas Conrad Austin Lewis and his Confederates were apprehended and brought to trial on 11 counts of Grand Theft Auto and one count of Kidnapping they were found guilty and sentenced as prescribed by law Grand Theft Auto is punishable by imprisonment in the state penitentiary for a period of not less than one nor more than 10 years Kidnapping is punishable by imprisonment for a term of from one to 25 years in the state penitentiary You have just heard dragnet the series of authentic cases from official files Technical advice comes from the Office of Chief Police W.H. Parker Los Angeles Police Department Technical Advisors Captain Jack Donahoe Sgt. Marty wins Sgt. Vance Brasher heard tonight where Ben Alexander big parent Virginia Greg Jim Griffith Script by John Robinson music by Walter Schumann. Hell give me speaking Watch an entirely new dragnet case history each week on your local NBC television station Please check your newspapers for the day and time Chesterfield has brought you dragnet transcribed from Los Angeles Buy new Fatima the smooth smoke with Fatima tips of perfect cork King size for longer filtering and Fatima quality for a much better flavor and aroma This Christmas give Fatima in the special Christmas carton cork tip and plain ends to Merle Muller and the news next on the NBC radio network


Welcome to The Crimson Engine. Today we're going to talk about why I went $10,000 into debt to buy my cinema camera and how I feel about it a year and a half later. I bought the 5D Mark III about seven years ago now. I was shooting with it a lot but a year and a half or two years ago I realized I needed to get a cinema camera of my own. I was renting either a RED or an Alexa or a C300 Mark II a couple times a month and that money was just going and I realized that I could buy something for myself, get better at using it, put the money that I was putting into rentals into paying off something that I would own and possibly even be able to resell. I really wanted the new camera that I was going to get to shoot RAW because I had Magic Lantern on my 5D Mark III, really loved it, had done a lot of experimentation with RAW, really got to know the post workflow. I looked at the Ursa Mini and actually rented it for a job and just wasn't impressed. I think the size was the main issue for me. It was just too big for a lot of the things that I wanted to do, a lot of the running the gun stuff and also didn't have autofocus. When they announced the C200 it seemed like the perfect camera. I shot my feature on the C100 Mark II. I really loved the dual pixel. I really loved the form factor. A lot of my accessories from the 5D would move over to the C200 but it was a lot of money. I bought the B which is only $6,000 only but I still need to spend at least another three or four thousand on a bigger tripod, monitors, batteries, cables, shoulder rig, all the things that go with it. I think that's what a lot of people don't understand as they look at the sticker price of just the camera and don't realize that you're spending almost that much again on other things. Red especially is infamous for this. They have a low-priced body but you end up spending $1,000 on the memory cards. But calculating out the amount of money I would have to spend on the camera and the accessories, I still felt like it was a good investment for the amount of work I was already doing. Now I think this is an important distinction because a lot of people buy cameras hoping to get work. I don't think I would have done that. I only bought the camera because I had the work coming and wanted to make the best use of those rentals I already had set up. Another thing that you need to take into account is that you don't just have to cover the cost of the camera but you have to cover the cost of the interest that you're going to need to pay on the money you borrow to buy the camera. I bought mine through B&H just because it was cheaper. A year and a half later I don't have any regrets. Owning a camera, owning a digital cinema camera took my filmmaking to the next level that allowed me to really create this YouTube connect with a whole bunch of people, get a whole bunch of work I wouldn't normally have and really just shoot projects myself for no money that I'm really proud of that I would never have had the opportunity to do if I had to spend the $3, $4, $500 every time renting a camera for a day. My journey to camera ownership has been an incredibly positive one. I have no regrets. That doesn't mean that that's right for everybody. I am 40. I am pretty far along in my career. Like I said, I already had the work that I was going to use to pay this camera off and for me it just, I was just waiting for the right camera really. I didn't want to buy a red, not a fan of that whole camera system for a lot of reasons that I should probably make another video about. I didn't really like the Sony and the FS7, FS5 are kind of getting towards the end of their life. They didn't shoot raw. So when the C200 came out I kind of jumped into the pond with both feet and hopefully have been able to pass on what I've learned about C200 filmmaking on this channel and lots of exciting things are happening. Thanks very much for watching. Leave your questions in the comments. Let me know what other videos you'd like to see. Subscribe if you want to see those videos and I will see you next time.