It is now time for oral questions. I recognize the leader of Her Majesty's Oral Election. Thanks very much, Speaker. I would normally go to the Premier, but he's on his 10th paid sick day today, so I'm going to go to the Deputy Premier with my first question. Yesterday, the auditor confirmed that seniors in long-term care were abandoned to COVID-19, and we all saw the horrifying tragedy that ensued as a result. The minister yesterday refused to take any responsibility whatsoever, any whatsoever, and went on, in fact, in her press conference to blame everybody that she possibly could, including the Minister of Health. Speaker, the Minister of Long-Term Care has now had 24 hours to reflect on her response to the AG's report yesterday. My question would be, is it still her claim that neither she nor this government will take any responsibility or takes any responsibility for the tragedies that unfolded in our long-term care system with COVID-19? Mr. Long-Term Care. Thank you, Speaker, and thank you to the member opposite for the opportunity to clarify. As I said yesterday and have said repeatedly, I take responsibility. I have a duty and an obligation to residents, their families and staff in long-term care, and I have been absolutely consistent with that messaging. So I don't know why that wasn't heard yesterday. I want to thank the Auditor General and her office for her special report on long-term care, and she was very clear and very insightful that it is the long-standing issues in staffing and the lack of new development and redevelopment of existing long-term care spaces that contributed to the spread of COVID-19. And I had a very long discussion with the Auditor General on Monday, which I appreciated very, very much. We will take extensive and ongoing measures to protect the health and safety and well-being of residents. The $4.9 billion that is going to create 27,000 new staff for long-term care on top of the 8,600 and more that we created during the first wave and into the second wave. We'll continue to take measures to shore up a sorely neglected sector. Supplementary question. Well, Speaker, people who lost loved ones in long-term care don't believe for a minute that this conservative government is going to fix our long-term care system and they feel as abandoned as ever. They weren't surprised by the Auditor General's report at all, Speaker, but they were shocked by the response of the Minister of Long-Term Care. Fred Kramer, who lost his mother to COVID-19 in Orchardville, has said this about the AG's report and quoting, No surprises in it. They're getting away with not looking after the people in the homes. Why are they getting away with it in reference to the government? Kathy Parks also lost her mother, or rather her father, to COVID-19 in Orchardville. And Kathy says this, and I quote, I see comments from the Minister of Long-Term Care about how the government is fixing this. They're not. They have no intention. It's heartbreaking. That's how people feel about this government's lack of action in long-term care. What does the Minister, this Premier, what does this government have to say to people like Kathy and people like Fred? Thank you. Minister of Long-Term Care. Thank you, Speaker, and thank you to the member opposite for providing this opportunity to say what we have been doing and have been doing all along. Since the very beginning of our government being elected, we prioritized redevelopment in long-term care, 15,000 new spaces over five years and 30,000 new spaces over 10, in addition to redeveloping homes that were languishing from the 1970s all during the time that you were in support of the previous government in opposition. And I think that that record should be recognized in action of the previous government and the leader of the opposition. We've taken extensive measures, as I've said, on the staffing, on the redevelopment, on the building, on the IPAC, the 27,000 new hires that we are, positions that we are creating for long-term care to address our increasing incapacity. These are long-standing issues that we're addressing. Finally, it's our government. A conservative government is doing it. This is absolutely the facts. Let's deal with the facts. Thank you. The final supplement, please. We get the same story from this conservative government at every single stage of this crisis.  Speaker, we all know what happened in long-term care over decades, first under the Harris conservative government, then under the McGinty, Wynn and Del Ducca liberal government. Long-term care was abandoned by all of these folks, but this minister of long-term care and this conservative government under Premier Ford eliminated inspections. They cut funding. They ignored all of the warnings about what was about to unfold in long-term care. They protected private profits instead of lives, Speaker, and they're still doing all of that. At what point will this government start protecting the lives of people and start putting the lives of people ahead of private profits and their own political gain? Mr. Long-term care. Thank you, Speaker. I'm a big believer in dealing with reality and facts. Students in PSW programs that we announced yesterday, $86 million going to 8,000 new positions, funded positions for PSWs. That means 10,000 more PSWs are being trained in this province this year compared to years prior, something that the previous government never bothered to do. It's also our government that will be leading in Canada with a commitment of four hours of direct care for residents on average per day. This is something that has been left for many, many years. The previous government had report after report. It did not act. And I would ask the member, the opposition leader opposite to understand how many times she actually mentioned even the word long-term care. I think people can go back and look in the handset. It is our government that is taking action on long-term care, the first government in decades. And we will do it and we are committed and we have been ever. The next question, once again, the leader of the opposition. I have no questions to the Deputy Premier, but holy smokes, she's a year late. She should have been doing all of those things a year ago. We lost 4,000 seniors to COVID-19 in long-term care under her watch. So I don't think she has bragging rights, Speaker. But my question now is about the fact that this government, 407 days into a pandemic that's taken now 8,029 lives. Yes, we've now reached a very grim milestone in Ontario. They have refused.   I guess my question is, where did they come up with the scheme? Did they even consult their own COVID-19 experts and advisers when they drafted up this terribly inadequate plan? Minister of Labour. Well, Mr Speaker, we are going to continue having the backs of every single worker in this province until we defeat COVID-19. And Mr Speaker, we were the very first province in the country to bring forward job-protected leave last March for any worker in self-isolation in quarantine if your mum or dad that has to stay home and look after a son or a daughter because the schools are closed, you can't be fired for that. Furthermore, Mr Speaker, we eliminated the need for sick notes in Ontario. And Mr Speaker, I'm proud that yesterday that we announced the most comprehensive plan to ensure that workers are protected. They can stay home when they're sick and we're going to be with workers and small businesses every step of the way until we defeat COVID-19. Mr Speaker, this government's plan that they announced yesterday or the scheme they announced yesterday has been widely panned by pretty much everybody. The science table, of course, wasn't consulted because this government never listens to the science table. Why should they now, I guess? And here's what they say about this government's failure in their announcement yesterday. That the scheme is arbitrary, stingy, and, in the end, foolish. Doctors warn, of course, that it's too few days, that there's too little pay and that it might actually impact workers to put them in an even worse off position than before this scheme is put into place. You know, at a time when the Premier has just taken ten paid days off to appropriately quarantine as the experts advise us to do, why do they think that workers don't deserve the same thing to be able to quarantine completely and not have to make a decision between going back to work sick or paying the bills? Why do they only get three when the Premier gets ten? Mr. Blader? Well, Mr. Speaker, we are going to be bringing forward legislation this afternoon to bring in the most comprehensive plan in the entire country. In fact, Mr. Speaker, we are the very first province in Canada to bring forward paid sick days during COVID-19.  But Mr. Speaker, let me discuss some of the plans that's going to be in the legislation this afternoon. We have agreed to ensure that we're topping up the federal program. We want to make that federal program $1,000 per week for four weeks. We're the first province in the country to do that. Mr. Speaker, we are going to bring in, if approved by this House, three paid sick days. That's going to be flexible, open, no sick notes required to ensure that workers in this province, for example, will be paid to get vaccinated. My question to the Leader of the Opposition is, is she going to support us to bring in paid sick days for workers in Ontario? The final supplementary. Thank you very much, Speaker. You know, it's really, really important that the government get this right, and they haven't. People are losing their lives every day. People are 41 over the last 24 hours, lives lost. 8,029 people now that have lost their lives in this province to COVID-19. The ICUs are overwhelmed. 884 ICU patients right now in our hospitals. Essential workers have to put their lives on the line every single day when they go into work, and they shouldn't have to choose between a safe quarantine, as I've already said, and going back to work sick because they can't afford to pay the bills. I mean, I just don't get what this government's problem is. Why won't they ever make the right decisions to support workers, to save lives, and to stop the spread of COVID-19 in our province? Mr. Labour. Well, Mr. Speaker, I am truly disappointed to hear that the Leader of the Opposition and the NDP are going to vote against our paid sick leave program that we're going to introduce this afternoon. Mr. Speaker, yesterday the Minister of Finance and I announced that we're going to bring forward legislation to bring in the Ontario COVID-19 worker income protection benefit. We are the first in Canada to offer the doubling of payments for the federal sick days program. We are also introducing three paid days off for workers who need to stay home if they're sick. If they need to go and get vaccinated. If they need to recover from vaccinations.  We call on the NDP to stand with us today to stand. Thank you. The next question, member for Scarborough. We're so glad. My question is to the Minister of Labour. Mr. Speaker, throughout this pandemic, we have used the term essential workers. When referring to many of those in our communities like mine in Scarborough or in Peel, Northwest Toronto who never had the opportunity to find a safe alternative to in-person work. Since the beginning of the pandemic, over three million essential workers had to work in common work settings. When our whole province paused to stay home and stay safe, these workers never got to stay home or stay safe. They had to take crowded buses to go to work in unsafe factories, warehouses and other jobs where their health was jeopardised and then their family and community's health was jeopardised. Mr. Speaker, my question is, how do you define if a workplace is essential? Why are we in a stay-at-home order and a state of emergency in the middle of a punishing third wave and the government strategy is to ask people to stay home? So my question is, how do you determine if a workplace or a worker is essential? Thank you, Speaker. Mr. Speaker, the health and well-being and the health and safety of every single worker is our government's top priority. That's why, Mr. Speaker, we have now done nearly 50,000 workplace inspections and investigations related to COVID-19 since the pandemic hit the province. In fact, Mr. Speaker, we've hired more than 100 new Ministry of Labor training and skills development inspectors, which brings the inspectorate to the highest level in provincial history under this Conservative government and I have to remind the member opposite through you, Mr. Speaker, that she actually voted against our plan to hire more inspectors to keep workers safe. We've now shut down 90 unsafe workplaces and job sites related to COVID-19. Mr. Speaker, we have boots on the ground every single day into workplaces, partnering with local public health units to ensure that the health and well-being of every worker is protected. Order. The supplementary question. Speaker, let the record show that the Minister of Labor, after a year into this pandemic, failed to identify how they define essential workers or an essential workplace. We call them heroes, Mr. Speaker, who have deemed their labor essential, but we fail to take decisive action on how to protect them. In an early April memo from the Ministry of Labor outlined that just in 2021, they found 15,000 workplace COVID infractions, but only stopped unsafe work 24 times. We have been using the term essential worker to undermine the marginalization faced by those who are working precarious and low-income jobs that have put their health and safety in danger. Workplaces have been reported as a key driver in the COVID-19 numbers we have seen in Ontario. We are hearing from our community, from our health workers, that overwhelmingly those who are failing to falling sick are the ones working in congregate settings in factories like chocolate factories and cosmetics factories. So, Minister, my question is, why are these places like chocolate factories and cosmetics factories open, truly in a state of emergency? Why are you not taking decisive action to stop unsafe and non-essential work? Thank you. Mr. Labour? Well, Mr. Speaker, the health and safety of every single worker is being the government's priority from day one. In fact, Mr. Speaker, as a member opposite knows, because she supported this legislation, back when the pandemic, this invisible enemy hit Ontario, we moved decisively. We brought in job-protected leave that is impacted at all by COVID-19. They can stay home. They should stay home. Their job is protected. Mr. Speaker, we went further. We eliminated the need for sick notes in Ontario during COVID-19. And, Mr. Speaker, it was a spring of last year when this pandemic hit the province that we brought in hundreds of guidance, resources, tip sheets, posters, in dozens and dozens of multiple languages, Mr. Speaker, we moved to Ontario.ca forward slash COVID safety to ensure that employers knew what they needed to be doing, that workers knew what they needed to be doing. And, Mr. Speaker, we moved quickly to hire more than 100 new Ministry of Labour Training and Skills Development inspectors. And I credit them, Mr. Speaker, they've gone to 50,000 workplaces. They've done inspections and investigations and will continue to do so. Next member's question. Michael. Thank you very much, Speaker. My question is to the Minister of Health. I know our government, yourself in particular, have been working day and night to ensure the swift and equitable rollout of vaccines across the province. Or Ontarians across my right. And the province have continued to ask me when it will be their turn to get the vaccine and when can life return to normal and things get back to the way they used to be. Would the Minister please provide an update to the members of this House on the rollout? Minister Pell. Thank you, Speaker. And thank you to the member from Aurora for the question. Since day one, our government has been committed to vaccinating Ontarians as quickly and as safely as possible. And just a little over a week ago I stood in this House and spoke about the significant achievement we had made in making sure that we had administered over 3 million doses to adult Ontarians across the province. Well, today I am delighted to inform the members of this House that yet another milestone has been reached and we have been able to administer over 5 million doses of the COVID-19 vaccines. We know that many Ontarians are anxiously awaiting their turn and we're anxious to get the vaccines to them. And that's why this week we allowed individuals 45 and older who live in hotspot neighbourhoods to book vaccinations through appointments in our booking system. We are committed to delivering the most successful vaccination campaign in the country, Mr. Speaker. A supplementary question. Thank you, Speaker. And I want to thank the Minister and all those on the front lines for helping us administer these crucial vaccines. It's quite reassuring to see that light at the end of the tunnel grow brighter and brighter as more and more vaccines get put into arms. Speaker, while times are difficult right now for every Ontarian people can take comfort and the fact that our government will not rest until we defeat this virus which is why we committed to inoculating 40% of the population by the start of May. Would the Minister please provide an update on our province's progress with achieving that goal? Minister of Health. Yes, thank you again, Speaker and thank you again to the member for the question. Our government understands that vaccines are our way out of this pandemic which is why we have worked nonstop to ensure we can get as many shots into arms as quickly as possible. We are committed to ensuring that every Ontarian who wants to receive a vaccine will receive that vaccine as soon as possible and this dedication has led us to record breaking. Just last week we administered over 130 doses per day for three days in a row. The continued success means we are on track to exceed our target of having 40% of the adult population vaccinated with their first dose by the end of this month, by the end of April. As we've said time and time again we will do whatever it takes to make sure that we can protect the health and well-being of all Ontarians. Thank you. Next question, the member for Parkdale High Park. Thank you, Speaker. David owns a home decor business in my riding. He applied for the Ontario Small Business Support Grant in January and was approved on March 14th but he has yet to receive a dime. Sandra Lee owns a photography business and was approved for funding on March 7th. More than 50 days later she's still waiting for payment and the government is not responding to their emails or phone calls. Small business owners have been locked down for months. They will go bankrupt without this support. My question to the Deputy Premier is simple. When will the small businesses get the funding you approved? The Associate Minister for Small Business and Red Tape Production. Thank you very much Mr. Speaker and thank you to the member opposite for bringing that forward. We are working around the clock. We have hired over 100 extra individuals to support and ensure that businesses get the money that they need. To date we have processed over 107,000 payments directly through the first phase of the program totaling $1.5 billion. 57,000 businesses have also received a second automatic payment of that fund as well totaling another $850 million over $2.4 billion in direct supports have gone to these businesses. We recognize that there are still some challenges we are working through those and we are going to ensure that those businesses get the money as soon as possible because we do understand that this is a very challenging time and we are happy to look into those and support the member. This minister has no clue of the reality on the ground. So many small businesses are having problems with this program. Steve owns a moving company. He was told to upload his financial documents but the link he was sent doesn't work. He has called and emailed small business owners like Steve are trying to survive the pandemic. They need support now, not in weeks or months. They need an application system that works. When you promise something you have to deliver it or you're just wasting people's time and putting them through help. When can Steve and thousands of small business owners expect to hear from their government? Thank you very much Mr. Speaker and understand the member opposite and the concerns that she has put forward but we have also ensured that there are over 100 people tripled the support staff behind the program recognizing that we need to ensure that the money is getting out to all of these individuals and businesses. $2.4 billion of direct support has been paid out to small businesses. We'll continue to make sure that every eligible business that has applied for the program gets the money that they need. We've also ensured that they have access to getting 100% of their property tax paid, 100% of their energy cost paid. They can apply for the digital main street program which is up to $2,500 support grants and we also recognize that the federal government has programs in terms of 90% of their rent relief that could potentially be covered as well as 75% of their wage subsidy. We will ensure that we do everything we can to get the businesses the support they need and that's why $2.4 billion have flowed directly to small businesses across Ontario. The next question, the member for Scarborough, Scarborough Guildwood. The next question is to the premier. 30 days ago your government released its budget. There was no mention of a couple of billion dollars for paid sick leave. There was only an assumption that the pandemic would be over and you put a billion dollars into prudence. It is clear that the government did not want to support Ontario workers or they would not have resisted a paid sick leave program that medical experts and really all workers have been demanding since the pandemic began to protect themselves and their families. It is clear that the government's budget that they tabled last month was out of date before it even landed. The government finally put forward as paid sick leave program or is putting forward one which is full back measures and does not fully protect Ontario workers and demonstrates how clearly out of touch this government is. So will the premier commit to a fiscal update that contains the financial requirements for better paid sick leave, vaccination leave and testing so that we can keep the people of Ontario safe and ensure that a booster program is built into it. Minister of Labor training and skills development. Minister, I'm very excited about the legislation that's going to be coming forward this afternoon. In fact, Mr Speaker it is going to be very flexible very generous, very open the most comprehensive plan in all of Canada. In fact, Mr Speaker Ontario is the first province in the country to bring forward paid sick leave during COVID-19. So Mr Speaker, I hope the member opposite will support our legislation but I do want to point out one of the other important initiatives and parts of our legislation that will be coming and I said this yesterday Mr Speaker but we are also going to ensure that all small businesses and employers are reimbursed unlike the Ontario Liberal plan that came forward Mr Speaker that really would have bankrupted thousands of small businesses across the province and most importantly Mr Speaker workers wouldn't have jobs to go back to. Our approach I believe is the right one and we're going to stand with you. And the supplementary question. What happened to the Premier's promise for the best program in North America? Clearly you have not delivered. For over 400 days we have been calling for a paid sick day program. All members of the opposition have been doing that and Speaker this Government has fallen far short. Just look to the south. They have given workers 80 hours of paid sick leave to cover aspects of the pandemic. So Speaker three days is not enough to make things worse the government included all sorts of other things into the program that really deserves its own plan. So will you commit to the 10 days that the experts have been calling for because every day you delay and drag your feet people are at risk. So will you make this program much more realistic by providing 10 days and make it permanent so that people can have paid six days moving forward. Mr Speaker let me remind the member opposite that we announced that we want to double the federal program to $1,000 per week for four weeks plus three paid sick days. This is the most comprehensive plan in Canada. If a worker needs to take time off to get vaccinated they can be paid. If a worker needs time off to recover from a vaccination they can be paid.  Mr Speaker if a worker in Ontario needs to take time off to get vaccinated they can stay home and get paid. This is the most generous open and flexible plan balanced because we're reimbursing all small businesses and employers. We plead with the Ontario Liberals to finally step up, stand with workers in Ontario and join us today. The next question. The member for Mississauga East Cooksville. Mr Speaker my question is to the Solicitor General. With Ontario's vaccination campaign ramping up across the province this month I know that access to the vaccine in convenient locations is a top priority for many especially those who rely on public transit or who work jobs outside of traditional 9-5. Can the Solicitor General outline how our government has ramped up pharmacy vaccine clinics as part of this two of the province's vaccination plan especially for my community here in P. Thank you. Thank you and thank you very much for the member from Mississauga East Cooksville. I know he and I have had many conversations about the various phases and stages as we get a more steady and increased supply of the vaccines. So access to a convenient location to receive the vaccine is critical particularly for those who might be hesitant about getting the vaccination but where there's ease of access a deciding factor can help. That's why we've been working hand in hand with pharmacy partners from across Ontario to rapidly build up capacity in pharmacies allowing much greater local access within their communities. To date nearly 1500 pharmacy locations are able to offer the vaccines including more than 150 in seven of which are able to offer 24-7. Ontario's pharmacy and primary care practitioners have collectively administered almost a half a million doses of vaccines since they began only a few short weeks ago. Thank you speaker. Thank you very much speaker and speaker through you thanks to the Solicitor General. I know so many constituents are ready to roll up their sleeves to get vaccinated when it's their turn and these pharmacy locations are a great step in the campaign to get all Ontarians vaccinated but of course pharmacies are only one avenue through which Ontarians can get vaccinated with vaccine supply coming into Ontario expected to rise even more than it was in April. Can the Solicitor General share how pharmacies fit into Ontario's broader plan to ensure vaccines are as accessible as possible to the people. Thank you. Again Mr. General. Well thank you and again thanks to the member. I I'm proud to highlight Ontario's multi-pronged approach to ensuring everyone has access to vaccines as soon as supplies increase. This includes pharmacies primary care practitioners as well as hospitals and mass vaccination clinics as the backbone of our vaccine plan. We've also been working to bring vaccines directly into communities through mobile and pop-up clinics in hotspot neighbourhoods. This includes vaccine clinics in workplaces starting with Amazon, Maple Lodge farms and Maple League farms which also offer vaccination to the surrounding community. Additionally community-based clinics continue to open including the BAPS temple, Brampton and Mac Islamic centres and the World Sickness Earth Association. More will open as our supply of vaccines increase and arrive consistently. Thank you Speaker. Thank you. Next question for Waterloo. Thank you very much my question to the Deputy Premier. The Premier is on his 10th paid sick day today and we know that he still has another four in the bank. But for some reason he thinks that frontline workers only deserve three temporary days. What's good about him is that he's a privileged worker in this case the Premier is not good enough for essential workers who do the fundamental work in this province. So my question through you Speaker to the Deputy Premier can you explain why the Premier who says he's for the people thinks that he deserves better than the vast majority of Ontarians? Well Mr Speaker if the Government accepted the NDP's proposal or the Ontario Liberal proposal there wouldn't be businesses open in the province because you would have crushed thousands of small businesses across the province because you're going to put 100% of the cost on those small mom and pop shops across the province which is wrong. Mr Speaker our plan is generous. It is flexible and it's open for workers. We're going to stand with workers and families to get through COVID-19. Mr Speaker Ontario is the first in Canada to offer double payments for the federal sick days program to $1,000 per week for four weeks plus three paid sick days that's 23 days in total Mr Speaker. This includes a time off for people who get vaccinated who have to recover from vaccinations that they're having mental health issues related to COVID-19. We call on the NDP to stand with us and stand with workers in Ontario. I'd like to tell the minister your mishandling of this pandemic has crushed businesses. We're in our third lockdown in the province of Ontario.  You can't make explicit reference to the absence of any member in the House. I don't need the assistance of the government side with this. Thank you. Please conclude your question. Thank you very much Mr Speaker. He's still forcing everyday Ontarians to jump through hoops wait for weeks and just hope for the best while they're unable to pay for their bills. Where did you come up with the three days? Where did you roll the dice and keep gambling with the lives of the people of this province? If the premier deserves two weeks at his full salary why is this government trying to tell Ontarians that they deserve anything less? Mr Speaker I joined with the Minister of Finance yesterday to announce that we would be bringing for the Ontario COVID-19 worker income protection benefit. This will be the most comprehensive plan in all of Canada amongst all of the provinces. In fact Mr Speaker we're going to double those federal payments to $1,000 per week. It was an injustice that the federal government was paying workers here in Ontario below minimum wage. We're going to double those. Mr Speaker we're going to bring in three additional days. That's 23 days for workers in this province but we're going to go further. We're also going to step up and support workers so they have a fighting chance to prosper and grow through COVID-19 and after COVID-19 but most importantly Mr Speaker we want to ensure workers are protected they're kept safe. We defeat COVID-19 and that every worker has a job to go back to when COVID-19 is done. Thank you. Next question the member for York said. Thank you Speaker my question is to the Minister of Health and it has to be asked today because there are rumours that this government may adjourn to hiding when we're needed here most to deal not just with the COVID pandemic but the subject of my question which is the mental health pandemic created and continued by this government. Four days ago the CBC aired a story with Dr Justina Morrow an emergency room physician in Ottawa she said quote our department is filled with patients right now with mental health problems and patients also presenting who had no prior mental health history who are coming with a mental health crisis some of them are attempting suicide because they just don't want to live anymore during COVID and there are some elderly people due to isolation. Speaker this is caused by the longest and toughest lockdown on the planet. Everyone in this room knows it you get the same calls I do the Premier and this Minister are responsible for this catastrophe so I'm pleading with her now on behalf of millions of Ontarians will you please end this lockdown The Deputy Premier and Minister of Health Thank you Speaker the short answer is no of course we're not going to end this lockdown it's saving people's lives there have been thousands there have been thousands of people who have lost their lives and that is tragic that is truly tragic however if we had not taken member for York Centre is warned there would be many many more lives lost we are trying to preserve the health and well-being of the people of Ontario and save lives that's why we have to continue with this lockdown and that is going to be important for the mental health capacity of people going forward we know there's going to be locked issues relating to mental health as a result of the shutdown of surgeries and so on but at this point we have no other choice we have to be able to take care of anyone who needs to come into our hospitals we need to slow down the transmission in our community that's why the lockdown is absolutely necessary that we continue at Member for York Centre heard me he's been warned Supplementary question Speaker this government and this government has no shame they know the harm they're causing particularly to children lockdown is not the only option it has never been part of our pandemic planning and we know how much harm the lockdown is doing Dr. Jane Little an Ottawa pediatrician told the CBC yesterday I believe quote we've never seen this level of kids with major depression and suicidal thoughts Dr. Roszkowski Chief of Pediatrics at Queensway Carlton said it's not the pandemic that's causing this it's this government it's the lockdown it's the school being closed it's isolation that Ontario kids cannot bear anymore stop pretending it isn't happening so I asked the minister one more time on behalf of 2 million Ontario children will you let the kids again will you let them live again will you end this lockdown Minister of Health at the risk of repetition I would say no again because we are trying to save the lives of children adults seniors in this province this lockdown is necessary we've also brought forward our road map to wellness we knew that there were many people having mental health and addiction issues before this pandemic even began which is why we brought forward our road map to wellness program that is going to extend mental health and addiction services to the many people that need them they were not all caused by this lockdown some were exacerbated by the lockdown but they were not caused by this lockdown and we are going to work to make sure that every person in Ontario who needs mental health or addiction support will receive that next question the member for Aurora or bridges Richmond Hill thank you very much speaker my questions once again to the minister of health I'm aware that our government's vaccination strategy is focused on immunizing those most at risk older adults if they contract COVID-19 and hotspot communities who have been especially hit hard by this virus I know many Ontarians are anxious to receive the vaccine so would the minister please inform the members of this house how our government is making sure every eligible Ontarian who wants a vaccine is able to receive one minister of health thank you speaker and thank you again to the member from Aurora or bridges Richmond Hill for this our government has said from the beginning that our focus will need to be on protecting the most vulnerable in our communities which is why we are using a variety of delivery channels for vaccines to ensure that every person who wants to receive a vaccine can do so one of these delivery methods are mobile vaccination teams which have been deployed across the province and just recently started administering shots to those 18 years of age and older in select hotspot neighborhoods in Toronto and Piel additionally we included childcare workers in our vaccine prioritization to ensure these vulnerable workers are protected from COVID-19 this is a team effort and we will continue to work collaboratively with vaccination sites and other healthcare to ensure that we have the most successful vaccine program in the country member for Aurora thank you speaker I want to thank the minister and that's fantastic to hear that our government is making every effort possible to ensure vaccines are getting to those who need them I also know that we have made significant strides in the areas of testing in order to make sure Ontarians who need a test can receive their results swiftly I've also been told that our world-class testing system allows public health units to quickly be notified of positive cases of COVID-19 to take the proper steps to notify individuals and keep their communities safe would the minister please provide this house with an update on our province's testing strategy thank you thank you again to the member for that question and speaker our government knows that testing is very important in defeating COVID-19 and we've made it clear that testing is a priority the sooner we can identify cases that can stop the spread of this virus which is why we've made significant investments in our testing strategy that has seen over 14 million Ontarians tested we've been committed to protecting the health and well-being of Ontarians from the beginning of this pandemic this ongoing effort will ensure timely access to testing targeting testing to vulnerable communities and expanding the capacity to process COVID-19 so we will continue to work with Ontario Health and our sector partners on ramping up mobile testing and community testing in addition to having targeted testing campaigns for vulnerable populations across the province thank you speaker the next question the member for London North Centre my question is for the deputy premier speaker the province's vaccine has been an inconsistent and confusing mass that is excluding far too many people two of my constituents Colleen and Richard are both 58 and registered for vaccines at shoppers in Costco the minute they became available weeks later they've not received a call or any information as to when they can expect their vaccine Colleen asked me how is this possible that we were on the waiting list first but people in the next demographic are getting it before us this whole thing is a mess none of this is making any sense why is Ontario relying on a slap shot system with multiple vaccine waiting lists that leaves Londoners like Colleen and Richard falling through the cracks Minister Health for the question but I would say in fact we've had a very successful vaccine rollout we've already had vaccines delivered over five million vaccines have been delivered to date we are on track to reach our priority of vaccinating with at least one vaccine dose 40% of the adult population of Ontario by the end of this month we've also booked over 2.9 million tests through our online booking portal in addition to the testing that is available and the vaccinations that are available through our pharmacies we have over 1400 pharmacies now available to provide vaccines many of them are starting to offer that 24-7 so that people with different work schedules can be accommodated this is a great success we are making a priority to protect the health and well-being of Ontarians and we are well on our way with over five million doses already administered Member for London Orch Centre supplementary Five million doses is kind of a miracle with the lack of coordination the daily blame routine in the leader list deployment this supposedly business friendly system but instead the deployment has been a disaster it's back to the deputy premier speaker while Londoners like Colleen and Richard wait for a pharmacy to call them other Londoners have had to turn to social media in the hopes of chasing down a vaccine a few minutes after sending out a tweet about eligible vaccines one shoppers in London was overwhelmed with people hoping to get an appointment the pharmacies appointments were all claimed in less than an hour leaving countless people scrambling figuring out what to do next Tristan one of the Londoners lucky enough to get a shot said I think it's kind of bizarre that we have people who are older than myself on waiting lists to get the shot meanwhile there's people like me who can just roll right up Speaker it needs to be as easy as possible to book a vaccine it shouldn't feel like winning the lottery why is it that Londoners are finding out about how to get their vaccine on social media instead of from their government Well speaker I would say to the member opposite it's incomprehensible to me how you would consider the delivery of over 5 million vaccines in a short order in a little over a month is a failure in fact it's a great success and we are continuing to roll out those vaccines with over 2.9 million vaccination appointments already booked not to mention the vaccination appointments that are being booked through the vaccines the pop-up clinics that we have the many clinics that we have in various workplaces we're continuing to deliver the vaccines one of the problems we've had in the past has been the vaccine supply when we didn't have reliable supply chain we didn't have reliable delivery of vaccines but that is changing as of next week we are receiving significant amounts of the Pfizer vaccines we are receiving the Moderna vaccines we are going to be able to increase the number of pharmacies and other clinics are going to be able to provide them and we're going to be able to continue our job of making sure that every person in Ontario who wants to receive a vaccine will receive one in a timely manner the next question member for Ottawa Vandy my question is to the minister of labour it's really great that the government is finally taking action with a provincial paid sick days program after over 400 days into the pandemic maybe we can agree that this does not qualify as proactive and decisive action for paid sick leave to work it needs to be simple quick and seamless instead this program requires that employers be able to pay workers salaries uninterrupted submit claims and wait until they are reimbursed the science table has clearly outlined what a paid sick leave program needs to look like to be effective at bringing the numbers down this program does not fulfil those requirements in the US the introduction of an effective paid sick leave program resulted in an estimated 50% reduction in the number of COVID-19 cases per state per day so knowing the science why then the government implement a universal and accessible paid leave program that would provide uninterrupted salary support for a minimum of 10 days minister of labour well thank you very much and thank you for this very thoughtful question in fact Mr. Speaker when the minister of finance and I made the announcement yesterday we ensured that we let people know that employers are going to pay the workers and then the employers will be reimbursed through the province and the WSIB is going to be administering that program for us to reimburse small businesses and all employers as quickly as possible but Mr. Speaker we do need to continue all of us together work together to get through COVID-19 in fact Mr. Speaker we need the federal government to accept our offer to double that payment to $1,000 a week for four weeks that will ensure that workers in Ontario are getting $25 per hour to stay home when they're sick and that will incend people so they don't have to choose between a paycheck and their health supplementary thank you Mr. Speaker and again to the minister of labour I hear from essential workers in my writing feeling abandoned by this government every single day many have gone to work sick because they need to provide for their families this no doubt contributes to the continued increase of number of cases in my writing this new program falls short of what is required to bring the changes and behaviour that we need to see to bring the numbers down but the implementation of this program requires the urgent cooperation between this government and the federal counterparts does the minister commit to cooperating actively and urgently with the federal government to implement a comprehensive plan as soon as possible Mr. Labour Mr. Speaker yes next question thank you speaker Mr. College and University tomorrow is April 30th April 30th is a significant date in Sudbury right now because the first phase of Laurentian University insolvency process will come to an end MPP Jamie West has stood in this legislature repeatedly asking your government to step in and stop the CCAA process and there's no more time to waste I'm here to ask once again will the minister put in place a moratorium on this process we need to maintain all programs and allow all students to graduate in the program they intended to graduate from without having to take any extra courses or pay any additional fees this entire situation should not fall on the back of these students will the minister finally do the right thing and save Laurentian University MPP Mr. South and parliamentary assistant thank you speaker as I've said in this house before Mr. Speaker we understand the very difficult situation that students families and staff are going through at Laurentian University I want to make it clear Mr. Speaker that 90% of students affected 90% of students have not been affected and that the 10% who have we are working actively with the institution to answer your question directly yes we will ensure pathways to graduation yes we will ensure they are not disrupted Mr. Speaker we're working closely with the institution to do that and while I'm up Mr. Speaker I want to say we've increased funding for capitals for our universities increased funding supports to support with COVID-19 offsets we've increased funding for our francophone institution $74 million this government commits to francophone education in the north we've increased funding for our indigenous institutes and while I'm at it we've expanded funding for our university when it comes to securing our post secondary future in the north this government has been there every step of the way thank you Mr. Speaker thank you Mr. Speaker Minister of Francophone Affairs the CCAA is about to be over tomorrow Francontarians all agree whatever which group we're talking about we are talking about one thing we talked about what we're expecting from the ministry we want this university to work for and with Francontarians as a minister for the francophone affairs what do you think thank you thank you thank you Ontario invested in post secondary studies in French we will invest $74 million in 2021 that's added to the million dollars we've already invested if the federal government really wants to support Francontarians and post secondary studies in French the government he should this government should start by offering more services what is really disturbing about what we're hearing from that member opposite is that Mr. Speaker the NDP have had only one opportunity to form government in this province one and in this question we see why what a chilling foreshadow of their attitude towards post secondary education they want politicians to decide they want politicians to intervene in independent processes led by educational experts perhaps the most concerning Mr. Speaker is they want thank you very much the next question the member for Ottawa South member for Ottawa South has the floor I live a few blocks away from the general campus the Ottawa hospital and I've always heard orange helicopters going overhead they're very close so they're very loud there's a story, there's a family up there I hear more helicopters now because we have to move people and I want to tell you one of those stories one of those stories is about Jamie Newian's uncle who's 72 years old there was no room for him in the ICU at Scarborough they transferred him to the Montfort hospital he died there no family no supports alone they had to bring his body back and they got a bill for a thousand dollars it's a lot of money for a lot of people and so my question to the minister is Mr this is Ontario can you commit to ensuring that this family isn't out of pocket for this and that we ensure that patients who pass away are repatriated to their family at our expense thank you well first of all it is a tragic circumstance that this person passed away so far away from their family and my sincere condolences go out to his family but you're absolutely right no one should have to pay for this transportation and every effort is being made we will ensure that this family is reimbursed I understand they had already paid the cost but we will ensure that they are reimbursed and we are working with the hospital right now to ensure that and we will make every effort to make sure this does not happen to anyone else thank you I thank the minister for her answer and what I would like to hear you say is that you will use your existing authority to instruct hospitals that patients regardless of transfer whether dead or alive we do not face any bill for the circumstances that we find ourselves in I know what it's like to have a loved one transferred just two nights ago my family and I were up waiting for that decision and thankfully our relative was transferred to a hospital in the adjacent community people are afraid people are concerned for their loved ones and they don't need to feel is a health system that is letting them down because the virus is doing that job so I really need to be able to tell Jamie today from my community in Scarborough that this was a mistake we are very sorry and it will never happen again to another family Minister of Health well I would say to member opposite you're absolutely right this should never have happened this is a very very difficult situation I know for many families where their family member who may be very old needs to be transported to another hospital another part of Ontario to receive the care that they need but they should not be paying for the costs nor will they be required to pay the cost in the future this information will of course be made available to all our hospitals as I said before should not have happened and we will make sure it doesn't happen again so thank you thank you the next question the member for York South West thank you Mr. Speaker my question is for the Premier my riding of York South West is designated one of high risk we still wait mobile pop-ups and permanent facility I have heard the government talk of facine hesitancy the only hesitancy in our community is access to vaccines in addition to this government needs to pay workers so they do not lose wages while getting vaccines and those essential businesses they work at are asking the government to help arrange uncover casters of vaccinating workers on the spot will the government be proactive and move to take those effective measures to protect workers and their families Mr. Thank you thank you very much to the member for the question we are going to be accelerating our efforts because of the vastly increased supply of vaccines that we will be receiving throughout the month of May primarily Pfizer but also Moderna and we are going to be having more coming to mass vaccination clinics more to primary care centers more to pharmacies and more to pop-up and mobile clinics in workplaces or in places like industrial parks for example where people from smaller businesses can come at a time that's convenient to them perhaps on lunch hour and a break after work where they can come in and receive the vaccines we want to make this as easy and as accessible as possible for people and with the increased vaccines that we will be receiving we will be doing that in those pop-up mobile clinics throughout the province Thank you very much that concludes our question period for this morning I understand the government host leader has a point of order yes thank you mr. Speaker mr. Speaker I'm fairly confident that if you seek it you'll find unanimous consent to revert immediately to introduction of bills The host leader is seeking the unanimous consent of the house to revert immediately to introduction of bills agreed agreed introduction of bills I recognize the minister of labour training and skills development well thank you very much and I thank all colleagues mr. Speaker I move that Lee be given to introduce a bill entitled an act to amend the Employment Standards Act 2000 and that it now be read for the first time Mr. McNaughton has moved that Lee be given to introduce a bill entitled an act to amend the Employment Standards Act 2000 and that it now be read for the first time is it the pleasure of the house that the motion carried carried This is a bill entitled an act to amend the Employment Standards Act 2000 first reading of the bill from your lecture due for a little while I'll invite the minister of labour to briefly explain his bill if he chooses to do so well mr. Speaker people shouldn't have to choose between their job and the health that's why we're bringing forward legislation today to bring forward to all workers and their families in Ontario the most comprehensive plan of all the provinces in Canada to ensure that there's three paid sick days legislated through the Employment Standards Act and that we continue to push the federal government to double to $1,000 a week for four weeks thank you thank you introduction of bills point of order I would seek unanimous consent to immediately pass the Employment Standards Act 2000 Government House leaders seeking the unanimous consent of the house to immediately pass the Employment Standards Act the bill pertaining the Employment Standards Act 2000 it was just presented agreed heard and no I'll say one last time introduction of bills there being no further business this morning this house stands in recess until 1pm


Hi folks, my name is Gabe Gossett and I'm here on behalf of Western Libraries and presenting this finding and using sources workshop Glad to have you with us here today And as you go through this workshop one thing that we'd like to emphasize with you is Feel free to pause at any point if you have any questions if you want to ask our staff about that You're gonna be able to connect with our research and writing studio staff that is the folks that support these workshops So we invite your questions very much Whenever you're on our libraries websites You should be able to find some chat boxes where you would be able to ask those questions when they do end up coming up Okay, so for this finding and using sources workshops We are going to be focusing on a couple of different strategy-based Activities in order to actually help you get worked on in relation to the project that you're working on whatever that project may be So if it kind of give you an idea of where that's going if you take a look If you take a look at the image that you see here, it kind of gives you an idea of where we hope to go So hopefully what you already have at this point is something that resembles an inquiry question So that it includes the topic, but it actually includes a phrased statement as well that indicates the type of thing that you're going to be Doing your research on and if you don't have that then you can kind of work on that as part of this workshop as well But the other piece of this that we want to get into place is a series of sub-questions now These sub-questions are pretty important because they become really the component parts of the paper or the project that you're going to be working on They're kind of the the subsections that you're going to end up having later on those are going to become a series of sub claims your inquiry questions are going to become a thesis statement and Hopefully they'll all kind of come together through these things that we're calling those rhetorical moves Which we'll talk a little bit more about later Now as you can see there's a series of sources as well these little circles here The the different circles that we got that are have their arrows connecting to the sub-questions Those little circles are the types of sources that might be speaking to particular sub-questions like answering the questions that we have and so what we're going to be encouraging you to do is to Focus your research on these sub-questions that you are going to put together in relation to your inquiry question And then do your research in relation to those sub-questions and the reason why this is really helpful to do is because it kind of frees You in terms of how you can engage with Your inquiry question and finding some of the sources that you're looking for Instead of trying to find that perfect source that answers the entirety of your inquiry question What it's going to allow you to do is to find sources that just speak to the component parts of it And then it allows for your voice to come into it a whole lot more too so you as an author are now going to be able to speak in conversation to the sources that you're finding and Then you will be able to make some unique statements and unique claims and have a more effective paper overall


That was the talented kai gai, Maureen. Yes, she is a talented artist. She is a makeup artist as well. We'll be getting to know more about her and her plans. What are her plans in this industry? It is not easy. Welcome to the show. Thank you. So, it's all over. I think I'm only a girl child. I think I'm only a girl child. This is the latest video. Okay. You make some hair. At your anxiety. At your anxiety. Anyway, I'm excited. Yes, you're excited. Of course. The kai. One guy. Hey, where? You can introduce yourself to our audience who are your names. I have saved them already. And then tell them what you do. Hi guys. I'm kai gai K.E. My name is Tamo. My name is Yanda. I'm a makeup artist. I'm a beautician. Like I do nails. Yeah. As in kilaki to your beauty. But I specialize more on makeup. And I'm a musician. Oh, nice. We have a lot of ideas. So, what's your idea? It's up to me. I'll tell you what's up. But I will explain. We understand. It's okay. It's alright. So, like you told me, you started music very recently. So, tell us a bit about that. And what made you decide that? Okay, I need to do a song. I need to get into the studio. I've been singing. So, I came from Douglas. From primary high school. Then, after school, I didn't concentrate on music. I was doing my other stuff. But I went into the studio. And produced a song for him. And he was like, I don't know what to do. I don't know what to do. He told me, can we do a cover song for Zaniskiya, you can do a cover song for Jovio. But I took a release. Then, I came into the studio. Ten years ago, I made a cover song for him. Then, I asked him, I made a video. It was not even planned. So, I made a video. He laughed at me. And he recorded it. He told me, I made a video. That's how he started. How descent was this? I released a song three weeks ago. In March. I am shocked. I am feeling shocked. I am shocked. Please. Three months. Three weeks ago. How is the reception of this particular song? So far, so good. I like the response. I want to know what is the vibe of this song. What is the relationship between Zaniskiya and Jovio? I think it's a good idea to do a cover song. Character development. You don't say. I think it's a good idea to do a cover song. So, what is the relationship between Zaniskiya and Jovio? What is the relationship between Zaniskiya and Jovio? So far, so good. See, where is the complain? I have enough. 11,000 views. Almost 12,000 views. Almost 12,000 views. Three weeks into being very new in the industry. I think that's good. You're doing well. So, being new. What are your plans? Are you planning to do your own song writing? You want to be science to a label? You want to get a manager? That's too much for you right now. I'm still learning. I'm so new. I have a songwriter. Go produce a wango. I have an icon. I'm a songwriter. I learn music. And I take through your journey writing and production. About being signed. Not sure right now.  I learn a lot. We will say about it. Any challenges you've encountered so far? Challenges. Challenges. Yeah. Challenges are like I have a studio, a record, a video, a YouTube and a lala. Shok on you. Shok on you. Kila siku diko. Plan, distribution, promotion. Isu ni ni. Laki ni I thank Watu enya wako around me sana. Wama kwa kwa industry so wa nani yambia. Tabut try hi na hi na hi. Fanya iwi na iwi na iwi. So yeah, challenge ni na ndelia kulaan. But at least ni kona wato na nishikam kon. So it's okay. Yeah, that's important. Nani po wato opushikama. I mean kono mape ma. Kus watua me teseka wukunjo. Watua wenya nga niwa. The stories we've had here. They're just crazy. I know. So beware of such people who are just out here trying to take your money. Wata kuzumusha iwi o sitri letal pesa tukpe leke intervi palewa I-254. Sava sava. Okay. So once your music career takes off, is it something that you will do full time when it comes to beauty, makeup and everything? Yes, I want to do it full time because when it comes to music, it heals my heart. It's all about music. Music is life. I want to do it for the longest time when it comes to music. God. Yeah, I want to do music. Do you ever? But it's about makeup. But music bale. Music bale. Yes, yes, yes. But before we get there, I want to do it full time. Yes, production. So after all over, what is the next? You say that you have a couple of other songs that you have recorded. Which one is the next one here expecting from you? Next song. This one is a banger. My friends are too late. I am too late. I am too late. I am too late. How long have I been in this business? I have been for a long time. I have been in business for a long time. I have been in business for a long time. I have been in business for a long time. But I am too late. I am too late. What is the next song? The next song is for a boy like Kila Kitu. I love you boy. I think we're not there to see reality. Okay then let's make sure we've got the information we need and we'll take advantage of that. Save the information, we'll try to collect the information we need. I mean I'm saying it only for me I'm not sinping anytime soon. How's simp? Of course. Ayee. It's the same question I ask. It's okay. It's okay. You know what's even better? I'm thinking right now. So I'm saying that it's okay, I'm in the same box that is in a feint. Imboksi la kwa gadya kuflad Okay, okay, what a teacher What to view the demo?  Ya, is a banga, ewa tu tudiya chilie jue menisha ni fupe Tu ziya chilie to dance To dance Kha? Si gaengeton Si gaengeton ni chayata yeh yeh yeh yeh ya oke tuta-tuta kuja kuilangyya kwa kama yeh scariku kusama uu niyo ..... As you wind up if you had to choose one meal ndu utakuna for the rest of your life go to grow up mm for the rest of your life wa kumuku bade lisha si cha stat giverik alla That's a new one Why, why Giveri? Giveri sila zimei kuya muka Ah, but kule piti e-mail for 4 years kama muka I just got out of high school Una kule na se-mail wajulab da mei kula kutaka akiwa 3 years Ya lakwa akiwa akiwa akiwa 3 years Una kule na se-mail wajulab da kutaka akiwa 3 years Arasi tuli kuya boarding school, lakini una jo uchiwa high school kune kale kawukora Una taka special meals So ukuikula, sukuikula sana Una kuna filmi cele sana So right now the takasana Sayu neza kula Giveri fadalesha From mande to mandi Allah, that's a new one Nene kagotu, spina achi kini nene Eku na Giveri muka, al show you a video of Giveri I'll show you a video Where can people find your music? Where can people find you for make-up services? Make-up services? Emprestouch Pejangu ya beauty ni emprestouch You can go check it on Instagram My music is on all media platforms Na jitatu kai gai ke Then Instagram, Facebook, Snapchat Kila mahalili kai gai morin Okay, thank you so much for coming through And there is a compliment from our director Anasema ume waza Muchi, erita muchi Anasema ume waza Na jala me waza Muchi Maniga What's your language? What's your language? I'm a guy I don't know Anyway Itadu kukupeleta confidence to come here We'll see you in the next video


Hello, my name is Mariana Parabichka and I am a research associate at the Galat Laboratory, which is located at the Simpson Quarry Biomedical Research Center and affiliated with Anne and Robert H. Lurie Children's Hospital and Northwestern University-Findberg School of Medicine. On behalf of all the authors, I would like to say thank you for the opportunity to present this research. Hello, my name is Ekaterina Galat. I am also a research associate in the Galat Laboratory. Together with Mariana, we are the lead co-authors on our paper titled Down Syndrome-induced pluripotence stem cell model in the thylial insights into tumor development. My name is Vasily Galat and I am head of the lab. My lab has a long-standing interest in disease modeling. In fact, we are the first to establish embryonic stem cells from human embryos with genetic disease. These days, we are using reprogramming technology to develop patient-specific induced pluripotence stem cells or IEPCs. These stem cells can be differentiated into different type of cells and used for research and testing. This concept is known as a disease in the dish. The Galat Laboratory has several ongoing projects involving hematopoietic differentiation. For instance, we study natural killer cells produced from IEPCs for immune therapy applications. In this particular paper, we are presenting our investigation of IEPCs derived in the thylial cells. When the thylial cells play a pivotal role in blood formation and we shoot them to study trisomy, chromosome 21 implication on leukemia development in down syndrome patients. And the thylial cells are not easily attainable from patients. This is why our endothelial IPAC model proves to be so useful. While deriving endothelial cells from down syndrome patients, we noticed that down syndrome proliferative response to vascular endothelial growth factor differed from control IPACs. This finding coupled with clinical data showing that down syndrome patients have high incidence of leukemia and decreased solid tumor prevalence motivated us to further analyze this down syndrome endothelial progenitors. For this study, we performed endothelial derivation, bioinformatic analysis and functional assays. Regarding the bioinformatic component, we utilized various cancer databases and carried out extensive pathway analysis. The functional assays targeted proliferation, migration and inflammatory response, which are processes that tumors employ to create a favorable niche for growth in order to transition into a more invasive phenotype. Our analyses revealed several notable aspects. For example, we observed an increased expression in leukemia-associated oncogenes. So for example, gata 2 and notch 1, and decreased expression of genes involved in regulating inflammation, such as IL-6, IL-8, CCl2. And we believe that this genetic profile is contributing toward a leukemia- conducive microenvironment. And importantly, most of our identified endothelial genes have not been previously highlighted in down syndrome research, which is predominantly centered around genes expressed on chromosome 21. I would say that one of the most challenging aspects about this study was the optimization of endothelial derivation to ensure that our endothelial progenitors demonstrate the appropriate molecular and phenotypic characteristics. At the time when this study was initiated, an efficient endothelial derivation method was not available. As a result, we dedicated a significant amount of our time to establishing a robust endothelial differentiation protocol. A surprising aspect of this study was that the upregulated leukemia-associated oncogenes and the differentially expressed genes linked to proliferation, migration, and inflammatory response were actually not located on chromosome 21. And this significant finding emphasizes how trisomy 21 is capable of leading genome-wide alterations that result in down syndrome endothelial dysfunction and increased leukemic susceptibility. And we actually observed similar genome-wide dysregulation in a recently published parallel study that incorporates mesodermal cells. This work shows that processes underlying connective tissue impairment in down syndrome patients also potentially hinder solid tumor progression. So overall, down syndrome provides a unique, nontraditional lens to study tumor development. We defined a list of candidate gene of interest. The next step of our investigation would be to perform in vivo verification of these genes. If our results are confirmed, we might have new gene targets for leukemia treatment, which is very exciting. Thank you for your attention. Please read our paper and contact us with any questions you may have. Thank you again.


Hello, guys. Hi, everyone. Hi, guys. Hello, everyone. Welcome back to- Hi, everyone. Welcome back to my channel. No. Hi. Hi, guys. Hello, everyone. What's up? Welcome back. I'm so strange. I don't know how to film videos anymore. I haven't filmed them in like two weeks. Hello, everyone. Welcome back to my channel. It is Drew here from Lone Fox and honestly, I have not- I don't even remember how to film videos. Like, I'm very shook right now. I have not filmed a video in two weeks, which is so unlike me. And I am just back in my jam today and I am so excited to kick off 2019.  This has been a video that has been super requested by you guys and I've done them twice on my channel in the past. I definitely want to give credit to the Sorry Girls here on YouTube, which I will make sure to link their channel below for you guys. They actually have a series as well where they DIY your DMs and I saw it on their channel. I was like, this would be so much fun to do on mine and I absolutely love it. I've done two videos in the past, which I'll make sure to put in cards up here if you guys want to check them out. So yeah, basically you guys asked for these projects and I'm going to be delivering them in DIY form for you. And if you are not already, make sure to subscribe to my channel. I post brand new videos here on Lone Fox every single week on Home Decor, DIY, and make sure to click that bell icon next to the subscribe button just so that way you are notified every time I upload brand new videos. I think we're over me speaking at the moment because you guys have literally been neglected of my DIY project recently, so we need to jump right in immediately. So let's get started. The first project I'm going to be creating today was sent over to me by Bren underscore Delport and he or she sent me this image here, which I'm going to pop on the screen. It's probably easier for you guys to see, but it is basically these really, really cool kind of geometric air plant holders. And there's a wooden version and there's also a cement version. Now I feel like the wooden version is pretty self-explanatory.  But I'm going to be doing the cement one today because I want to share with you guys how to create your very own DIY mold, also mix up the cement, pour it in and then just create that little wire twister so we can create our very own air plant holder. Let's start crafting up these air plant holders.  It's kind of like what book covers are made of and what I'm going to start off by doing is using a ruler and pen just to mark out my cut sections. And the cut sections you're going to be needing are four pieces at three and a half by five and a half inches and then one piece at three and a half by three and a half inches. And the best way to cut this chipboard is to use an exacto knife and a ruler and to just go over the same section multiple times until you reach like the bottom and then you cut through it. And I also had a piece of wood just to protect my surface that way that exacto knife didn't like mar my marble surface. So these are the ending result pieces and you're going to need this little three and a half by three and a half pieces as well. So what we're doing is we're going to be creating a cube with no top. So how I'm doing this is I'm using duct tape and I'm going to be duct taping these pieces together. And when you duct tape them, make sure to leave about an eighth of an inch in between as you could see here, then apply the duct tape that way when you fold it, there's enough space for it to fold on top of each other and kind of create that joint section and just cut out any excess duct tape that you don't need anymore. And then we're also going to be attaching all of the sides to each other. That way we have a finish off mold. And the reason I'm making my own mold is typically when I use cement, I could find something like a food container or a Tupperware or something that I can use as my mold, but there was nothing that was super cube shaped like this that I could find. So I decided to make my very own and this was the ending result. So just make sure that everything is nice and secure. You can add additional duct tape if needed. And I went ahead and got some of this concrete mix. This is just from Home Depot. And what I'm going to be doing is just mixing it up with a bit of water to create a really smooth consistency. I like to also only apply little bits of water and then really, really stir it because the water can go a long way. It might look dry, but when you start incorporating it, it can really easily get a lot more wet than you think it is. So then I filled up my mold and I thought this would be enough, but it only filled it about maybe two thirds of the way. So I created another batch of concrete and then just filled it all the way up to the top portion. Once that was done, I knew I needed to create this little wire section. So this wire here is a 12 gauge wire from Joanne's fabrics. And I just cut a probably like 12 inch piece and I'm just literally spiraling it as shown in the photo. It's a very organic shape. So there's no rhyme or reason to this and just make sure you leave about a four inch tail as well.  And when you stick it down to the concrete, there's no way this is coming back out. So I pushed it down in the center section here. Just kind of hold it there and you can put a toothpick or stick across if you really want to hold it.  And keep in mind, guys, that this is going to need probably about two more days to fully dry and kind of turn that light cement color because it's been encased in a mold for a while. So once this has come out, you could sand it, get rid of any edges, and that finishes off your little fin holder. This next project here is one that you guys have been asking me to do for so long. And one of my Instagram followers, her name is crown underscore underscore jewels, sent over a message. She said, hi, Drew, I would love for you to create a DIY version of DUI, I think not DIY version of the moon wall hanging in your bathroom. I love it, but I can't seem to find something similar. This is the moon wall hanging. Actually, let me get it for you guys really quick. This right here is actually the moon wall hanging. And I've had this in my bathroom for probably about six years. I got this right when I moved to college. I picked it up at Urban Outfitters. It was like 25 bucks. And it was just super cute. I love the way that it looked. And I was really into moons at the time. And I still really am. I love the way that they look. So I got this from my bathroom. I've had it in there forever. And you guys have been asking me to DIY this every single time I do some sort of bathroom video. So I'm basically going to be recreating this for you guys because it has been very asked for. So let's get started. To start at this next project, we're using that same exact chip board, just a scrap piece that I had. You can use cardboard, whatever you have on hand. And I'm using these lids to some candy jars to create a circle shape. And then using a smaller one, positioning it on the right side and doing about three quarters of that circle to create this moon shape. And like I mentioned previously, the best way to cut this material out is to just go over it multiple times with an X-Acto knife. So this took me probably about 10 minutes to do. It was kind of tedious. But once I got the shape out of there, it looked incredible. And it literally looked identical to the one that I got from Urban Outfitters, maybe even a little bit better, not going to lie. And I used a pen to mark where I wanted my holes to go or where I wanted them to start and finish. Now I have an industrial hole punch. I've just had this for a long, long time. So if you don't have one of these, you can literally use like a sewing needle or an awl or whatever you do have to create the holes. I just found this was the easiest method to do. And I also used a little bit of this iridescent golden paint while it's from the brand golden. And I just gave it a nice coat of this paint. And this is such a pretty kind of shimmery silver. And I also went along the edges with this as well. Originally, I wanted to figure out how I could do this where it was made of metal, but I was just like, I don't know how to cut metal. So I created it out of the chipboard, painted it silver, gave it a nice coat of Mod Podge as well just to kind of seal it and lock it in. And then I grabbed two spools of chain from Joann's and some jump rings. And the chains that we are going to be using for this are all cut to 14 inches in length. So I cut, I think about 25 of these 14 inch sections. And you're going to be attaching them to the moon shape with the jump rings. So here we are. I opened them with two pairs of pliers. I slipped the jump ring on the moon shape, slipped the chain through the ring, and then just closed the ring up. It's super, super simple. So once again, opened up the ring, slipped the chain on, slipped it through the next hole, and you're going to be working your way down. And then just closing up the ring. And all you have to do is make sure to pull the rings, pull one plier towards you and one plier away, and then slip the chain on. And then this is the finished off section. Once you are all fully done adding all your chain pieces on, you can add a little chain to the top, which is going to be the hanger. And actually has a thicker chain, but I was like, I'm just going to use a thinner chain. And I attached it with two rings. That's how you hang it up.  And then the last project is one that I've actually seen on Pinterest before. And I've been wanting to do it for a while, but I was like, I'm just going to put it off for now. And then someone sent it to me. And I was like, we're doing it today, which I'm so excited someone sent it to me. So Abby Danielle Rose is who sent it to me. And basically she sent me this image of a coffee table that was constructed of wooden crates. I have about 10 of these wooden crates. You guys have seen me use them underneath my sink in my bathroom storage video. I've used them in past DIY projects, but I also stocked up on like 10 of them when Joanne's had their huge sale. I believe they retail for about $10 each, but you can always get it use a coupon on them, which is great. It is the perfect storage coffee table. It looks incredible. And I'm actually putting my own twist on it just to make it feel a little bit more Lone Fox style. And yeah, let's just drew it yourself. You know, I had to save the best for last. So I'm using four of these wooden crates from Joanne's fabrics. And I'm also using two pieces of wood. I got these cut to 27 and a half by 27 and a half. And I'm also using these small hairpin legs. I featured these on my channel in the past and I'll link them below for you guys are from Amazon. So we're going to be working from the tabletop or the top of the table and then working our way up. So I put the top of the table facing down and I placed all four crates as shown on top of the piece of wood. You're basically going to be like locking these together in this like grid section. And how I'm going to be attaching the tabletop because I do not want there to be any form of screw on the tabletop or anything like that is I'm just using a super strong wood glue and just butting it up to the edge of that piece of wood and just making sure it's pressed down, adding a couple of heavy books on the inside and then working my way around. So you're going to be repeating this process all around. And keep in mind that these open sections that are facing the outside are going to act as perfect storage cubbies for really anything you need. That's what I love about this project. So I'm attaching them all around. Now keep in mind also the one that the girl sent me did not have any tabletop to it. It was fully open and they had a plant in the middle, which I just was not a fan of. So I really wanted to add a tabletop to mine. And this is going to be the bottom section here. So what I am doing is just placing down my legs to see where they're going to go. But I wanted to add some glue to the middle section just because I'm going to be adding a ton of screws as reinforcement to the outside edge. But there wasn't going to be anything really in the center. So I added a ton of glue placed down the bottom panel on top kind of added a couple books to the center of there. And then it placed all of my hairpin legs on the outside. These hairpin legs are so cute, by the way. And I used a couple of wood screws just to screw these down through our wood piece and then into the crate. I made sure they were long enough to go all the way through the wood and into the crate. That way it was super, super strong bond. So I did this on all four legs. And then once they were done, I also added some reinforcement screws where there was thick pieces of wood like where the screw would not be shown. So I just added these all around the edge just to reinforce the bottom of this table. You can also add a finish like Danish oil or a wood stain. But honestly, on my tabletop, I did not like it. I tried it on the scrap piece of wood. The Danish oil is on the left. The stain is on the right. And I just liked the raw wood itself. So 24 hours later, I flipped this table over and it looked freaking incredible. I am obsessed with this guys. Check it out. All right guys. So that was today's little episode of DIYing your DMs. I hope that you enjoyed this one as much as I enjoyed creating it. It felt so good getting back into the vibe of things and I'm very, very excited for what is coming in 2020. You guys have no idea like what I have planned. There are so many room makeovers, so many fun things. So if you are not already, make sure to subscribe to my channel. You can click the red subscribe button below and click the bell icon next to it because you want to be notified when I upload new videos and why are my hands so freaking white? Look at this. They are paper. I'm very confused. Like white and pink. What is that? And lastly, don't forget to follow me on Instagram at lonefoxhome and you can DM me projects you would like to see me create here on my channel in this little DIYing your DM series. So I will catch you on the next one. I hope you have an amazing rest of your day and yeah. Bye guys.


Surprise! There's three of us. For those of you boys and girls that don't know, I am a triplet. I am here with my lovely brother and sister today. We are all turning 28 this year. Yay! Since you guys know so much about me, I'm going to let them do at least some of the talking today. And as you guys make a notice...  I'm just trying to do Frank a favor and not try to take too much of the spotlight from him. But listen, listen. If you guys can support frankiesfreerangemeat.com, maybe I will be able to afford to buy my brother a razor this year. So guys, please free order your high quality nutrient-dense animal food products at frankiesfreerangemeat.com. It's delicious! This is actually the order we were born in. So I'm going to let... As much as I'd like to let the ladies go first, this makes more sense. I am a delicate flower, so I appreciate it. Hello boys and girls. My name's Dante. This girl's brother. This guy's brother. Right smack dab in the middle by about 10 seconds. I work out in California. I do aeronautical engineering. I'm trying not to say uh. I know you guys don't like that. And yeah, I've been out there about two years now. Got an ocean view. So I'm only moderately depressed any given day. I get a little bit of vitamin D being out there. And it's nice not to have to shovel snow. But yeah, like I said, I've been out there about two years. I do magic space science. It's all fun. No one really cares about it. It's there to screen all day. But it's a lot more glamorous on paper. It's a good look on my Tinder profile when I tell them I do rocket science. But then when I tell them I just stare at a screen all day, they don't like that so much. But yeah, LA's great because the people are terrible. People are really shallow. They're all trying to be Instagram influencers. And they don't make their own meat though. So this guy's got one up on them. So you want to get yourself a nice influencer who makes their own meat. Good meat. That's what you want. His meat is delicious. We have a lovely sausage girl here. I am a lovely hot dog boy. We both love our cylindrical meat. I don't know what that means. Tell them how hard you worked to be where you are in the academic world. Oh man, yeah. So no, I joke about having depression because you sort of have to. Because I don't know anyone who finished grad school without at least debilitating their mental health a little bit. So I went to study physics in undergrad for three and a half years. I graduated a semester early to save myself for money, which is a bad idea because the real world is a scary dangerous place. So you want to stay in college for as long as you can. So you don't have to deal with it. So yeah, I studied in undergrad three and a half years. Took a little break in between. And yeah, then went off to grad school upstate New York, which was a terrible decision for another three years. So I didn't have enough of the nuclear winter style full ride to what was in it. Full ride to RPI. I tried to say some nice things about RPI, but I don't recommend it. It's in the city of Troy, which is probably the worst city in New York. It's between that and the Bronx. Although all the... Troy is where all the gang activity from the Bronx is migrated because the Bronx is too expensive for most of the gang bangers there.  So Bronx or Troy. Bronx or Troy. So all your kids out there, if you want the rents cheap, rents cheap. So yeah, that's what you're about. But anyway, went there. So spent three years there. Get my PhD, finish it quickly because my advisor... I'm going to put it delicately. She got fired. And so I had to wrap things up or else they were saying, you could start over if you want, but no one wants to start over after three years of writing magical and math-based science notes. So anyway, seven years of school and I'm not bitter about it. It's just, you know, Frank takes home about as much money as me at the end of the day. How many days, how much school did you finish, Frank?  So anyway, if I knew that I'd make that much in skip seven years of school studying magic-based science. I might have just started making videos about me. So here we are. And of course, my lovely young sister, Jean, who's been in her own little world for the past few months. Hi! Jean, why don't you tell them what you like doing? You want to tell them what you've been doing lately? Well lately I've been working at... I work in retail at... You don't have to tell them where. You can just tell them you work in retail. I work in retail. We don't need you creeps to find out where she's at now. I have two wonderful brothers. We only talk about you, not us. As you know, I'm a triplet. I have two brothers. What's been annoying you lately? What's been on your brain? Jean, why don't you tell them a little bit about how much weight you lost? I lost 45 pounds. I feel great. I ate lots of meat, proteins, eggs. Meat. Meat, cheese. Meat. Way too much cheese. Don't forget meat.  For those of you who don't know, my sister has been following carnivore meat-based diet for about a year and a half, two years now. I thought it was three. Maybe a little less than that. It seems like longer. It feels like a thing.  But it's been working. She feels good. She looks a lot healthier. She's much more energetic. Much more bothersome, so to say.  Gina, you guys have always asked me a lot about my sister's weight loss and me doing a video with my sister. We might do one on that separately in the future. Gina, you're always watching my YouTube videos. Did you have anything you wanted to say to my audience? Yes. I know he's a freak. I live with that daily. I come to peace with it. First of all, if he gave me raw meat right now, I'd probably slap him in the face with it. You can judge a man as much as you want.  You are what you eat. So Frank's the night ball. Does he do some weird...  Animal testicles. Balls. Is anyone allowed to say that on the camera? I think you can say testicles. Can you say balls? Balls. There's a bunch of words that we're not allowed to say. I don't think those two are them yet. Gina, did you want to let them know anything else? Sure. I'm actually... I'm into reading lots of books, YouTube videos. I like to stalk my brother on YouTube. And lately, I've actually been using my mom's Facebook to troll my brother Frank and Donald to see what they're up to. It's a very dangerous game. Because they don't tell me what they're doing. So maybe you can help convince them. You're really good with the books. Is there any recent book you read? What did you read today or yesterday? Didn't you get that book on... Ancient Egypt. I'm into Ancient Egyptian stuff. So maybe hopefully me and my brother could do an Ancient Egyptian video. You're very meticulous, right? She had her dad recovering the whole book. Just so it lasts. I'm obsessed. I admit. Everyone has their quirks. My brother is Dante. His quirk is being too smart for his own good. That's not the one I would have picked. Being smart. My brother's quirk is being... How should I put it? Unusual. So we can see which brother she has the warmer feelings towards. My quirk is being too smart. So as you guys know, Frank is very, very strict in his carnivore diet. Pretty much... What is it? Animal fat. Red meat. That's it? No. You do butter? You do cheese? No. Bad experiments. Bad experiments. Well, because you're actually allergic to eggs and stuff, right?  So I can pretty much eat whatever I want. I don't do carnivore anything super strict, but I did train powerlifting for a few years. I'm pretty casual about it now. But I'm pretty much just trying to make sure I keep my protein high.  You'll do all right. So I don't keep it as strict as he does.  I don't make sure that everything's super organic or super fancy, schmancy, because I'm a bit of a... It smells like...  It smells like an actual... I mean, I'm sure they're... First of all, they probably want to know like what your powerlifting total was. And what's really interesting about this whole story is he literally started weightlifting when I stopped pretty much. And that was like what, five, six years ago now? Yeah, so it's actually kind of funny because I remember we used to go on vacations and Frank would go with my dad. They would go hit the gym and I'd be like, that's so frickin' dumb. Why would you want to live weights? And then I weighed about 110 pounds. I ran cross country at the time and my diet was pretty much... It's funny when I look back and realize that I'm amazed I'm still alive, that I'm not like four foot three or something with what our diet was growing up. I think like my standard diet in a day, and this is a kid like on the track and field team running cross country, was I would have, I think, bull accountant crunch for breakfast. No milk, didn't like milk at the time.  I think as soon as I hit three years old, I was like, I don't think I like milk. And my parents were like, all right, that's a fair thing to let a three-year-old decide about themselves. So we won't make him drink milk or anything. So I think my standard day, breakfast, cat and crunch, dry. So you can move from my mouth and be bleeding the rest of the day. I'd have an applesauce around 10 o'clock. I'd have on one to bread, cream cheese and jelly sandwich. You get all three basic food groups, cream cheese, jelly, white bread, beautiful. I'd have a cream cheese and jelly sandwich after an applesauce, after a bowl of cat and crunch. And then I think that pretty much be it. I think sometimes I would get a cafeteria lunch and that'd be something like pizza, but pizza has cheese. So, you know, protein. And it's a vegetable now, I hear. We had a pretty, I think all of us had a terrible, I don't have a good memory. I literally don't remember what I used to eat as a kid, but apparently he does. So what were your powerlifting total numbers as a natural? So skip forward five years. I think my numbers are pretty close to what they were at their highest. I haven't been training as seriously lately, but I have dropped a lot of weight. So my strength to weight ratio is probably a little bit better now actually. So when I was less competing, I think at my meat, I weighed about 170, 175 right now. I'm shorty, 5'5". So if you're short, you want to powerlift way easier. Friends who are 6'3", they weigh like 50 pounds on me who don't lift as much.  We'll see who's meaner on the internet about it. But anyway, so 5'5". 185, my last time at competition. Bench was 315. Squat was, I believe 425. Deadlift was PR5. I want to say 550 or 560. So total was sitting around, I think my highest total was 1250 between all my best lifts. So that's at 170, 175. Totally natural. I don't even take creatine or weight protein these days. I just like to eat. So if I can get my protein from my food, I will. And I don't have the greatest skin. That's genetics. So what can you do? So the weight protein exacerbated that a little bit. Not enough that that would be my make or break for taking it or not. But I figure if I have a choice between going home and cooking up myself some chicken or something and having like half a gallon of really chalky chocolate weird. Oh, we get it. The point is boys and girls, you're not the only person with the Italian stone mason genetics. That being said, thank you guys for joining me today. If you guys would like to support the channel, just check out some of the videos I'm going to link at the end here. And of course, please like, subscribe, hit that bell icon. It's right next to the subscribe button. Share the video if you can. Jean, you want to say bye to everyone? Bye, everybody. Bye, guys. Like my brother's video. Subscribe.