Ronan and Sean you're welcome to the studio of Highland Radio to look forward to to the big event next week Thank you. Thank you I suppose that first of all Ronan will start with you because you came very very close to one on a stage in a previous race That's now five years ago 2012 What was it like on that occasion? I suppose first of all for you to be leading a stage of the race and Your home county didn't work out at the end for you at the end of the stage But it was a big day in your career Definitely was you know, it's a I think the stories Everybody's heard them at this stage and you know, it was a big day out for myself Unfortunately, it didn't work out how you would want it to but that's sport like there's no there's no gifts or anything you wouldn't you wouldn't expect anybody to To help you want to race or allow you to want to race just because coming into your home county And it would have been nice would have been a fairytale to finish it off But you know as I said, there's no gifts so it didn't work out that day. It's given me You know in some ways it was, you know, one of the worst things ever happened in a bike at the same time It was well, not the best thing and obviously but it gave me I remember that summer the drive and the determination I had just to you know, dig in and you know, prepare them for the rest of the season Really really drove me on like I was at home for the month of July that that summer and It just gave me that much determination They ended up getting into that good of condition that I was selected to go to the elite world championships for the Irish team and all like and That was the highlight in my career. It also gave me great form for the Tour of Britain that year And although I was always driven and determined and trained well I don't know if I would have went as deep that that year hadn't been for the disappointment of Bondorn But at the same time then it kind of got into that wonder It was always playing the back of my mind and for 2013 season I wanted to do is everything I could to try and won a stage and ended up doing too much and overcooking it and overtraining and Getting ill and losing too much weight and all sorts like so I had but it definitely had pro Pluses and negatives to to make career something, you know Well, we'll talk about later about possibly one in a stage in 2017 Sean, that's just gonna be an exciting week for you We know that the rolling here is part of a team you've created a team over the course of the last number of months when it was announced That it was coming to Doney Gall because it's your home patch and and you wanted to do it How big a task has it been to create Doney Gall Voodoo performance and put the whole package together just to get in The road next week. Well at the start, you know, I suppose it's hard at the start But when we got the feeders out there and a lot of businesses and a lot of local Help has come on board and they can know when the route come out Sean Stewart posted it to me said he up for it and I looked at it and I thought listen when it's coming to the home Country again, we're gonna have to give it another go like but we're there with a week to go. We're ready Well, I don't know if we're ready. We might we're ready. We have a team on my but we'll see how it goes And it's a Doney Gall team now you're the the soul Doney Gall writer on the team You brought in a couple of guys from Dublin, but it's very much And the background the foundations is all done. Yeah, it's all Doney Gall based It's like, you know, I mean we all are cruise Doney Gall Jason Black has come up with a kit Round over there's come up with the cars and like, you know, Kearn or Donald Jason McHugh, Jordan McGinley Brian McBride is a physio So it's all Doney Gall based where we thought we're gonna have a Doney Gall team at the time But it didn't work out that way because Ronan had been selected to Red, Franco, Blue And there's two Carter brothers from Doney Gall town that we're hoping that's gonna be on the team and Likes of Roy Devlin and Mark McClure and Mark McCannon that had done it before but things have happened and injuries and work commitment and they couldn't do it But I've been driving myself to get to the start line and we're there and hopefully things will go well What's your own personal conditioning like compared to 2015 because you competed five years ago as well Where are you now compared to where you are then? I don't know. I suppose I'm wiser to it now Like I've done a lot of more racing over the years back then we were told that we weren't able to do it in 2012 We weren't front enough to do it and Philip was home one year and we were doing a talk out in Girdon Lake And we asked him was it possible for a countervader to do the race and he said it was and we weren't supposed to talk We're on it as well asking was it possible and he was giving us a few tips about it. So Am I fit enough for it? I think he am I've done a few big races Recently the Shea Elliott and the two of the Morns and I've got around them. Okay. I've finished in the bunch Haven't been dropped out of the bunch. So I think I'm I'm fit enough but I'm more wiser to what it's like So hopefully my craft and my experience will get me around it again And few it's I suppose it's going to be more of a personal achievement to be just involved In this race because this is huge for cycling in Ireland and when we look at the UCI teams Under that banner that are going to come we spoke about it beforehand The team Wiggins is coming as just one example you have of course the the the Ireland team here as well So to be part of that and to get to the finish will be a huge achievement It'll be a huge achievement to get the finish like as I said Lining up against team Wiggins and lining up like aqua blue or you know all them teams It's to me is like a a many tour de France like you know me you don't get every day to race against them boys You know and hopefully we're going to set up a platform for younger riders coming through like at the minute Young juniors and donnie gall and overall over Ireland The standard is so high and you know you have as mark darling. No, uh, the world was track champion And mcdonnie's going to do you know to line up against them boys. It's going to be a good pleasure Ronan, it's a total different contrast for you compared to Sean's situation because Sean's sort of building the team and And getting as many volunteers together so that donnie gall can have a team on this But you're part of aqua blue. There's a strong foundation there. There's a system There's a backup team very much run more professionally. So what's your prep in like for this year's Ross? Well the Part of the reason I'm even on that team is you know to allow myself not to have the stresses off setting up team like I think I was a member of for the second club for the last couple of years and this year the opportunity came to go to aqua blue And it was a hard decision to make because they didn't really want to leave for it But part of the reason was that I just wanted to give absolutely everything to this Ross And I wanted to not look back and say if I had I just had a bit less pressure there a bit less stress there or But more recovery time it might have made it worked out. So I don't want to give myself any excuses I've been me training has been 100% Um, I couldn't you know, I'm not pro anymore. Not full time anymore. I'd have a full time job now And what I've done outside of work. I couldn't have done anymore. I couldn't have done any better And the whole year's been gauge or gated towards the Ross So the results have had so far have all been bonuses really I've just sacrificed everything else to try and go into the Ross as as good as I can um, the last The last few weeks now any time I've gone out I'm taking you know, I'm sure everybody in the segments how to strava You know I'm doing my best times on certain segments on strava and doing my best times on Climes that would test myself like they like some more gap I've gone up it quicker than I have done even in the Ross previously. I've gone up ground his gap different climbs You know a lot faster than I have done for for years now. So I don't think um, maybe the same situation. I'm not exactly at the high level I was in 2012 um, like my power numbers are maybe not just exactly as high or my weight maybe not as low but all around kind of Again using experience that I've gained since then and that I think all around them. I'm a better rider now and I'm kind of Got under the known as well that it might be my last chance to get a you know a stage one and on my goal or something so and that that alone You know will will help me What's what sort of scenario play would need to as opposed to fall into place or Or run out of if you are to be a contender for for a stage one Given what you just have to tell us that maybe you feel you're not to where you were in 2012 Well, hopefully nobody watches this video or listens to this interview Just doesn't realize that I'm in good shape, you know No, it's the same for pretty much every kind you're right Or we're we're kind of playing on the fact that maybe the international team's coming on their estimators Now the aqua blue jersey maybe isn't the best jersey they've been to be underestimated because it's associated with the team that rides Or it's got an invite to the the world of spainia and that and what's down though they'll quickly realize that we're not that aqua blue team. We're the feeder team and Hopefully then you just get a bit of leeway, you know And you're allowed into a breakaway or if it's all together in the attack with a couple kilometers coming under the finish That they just say well that boy is not going to be strong And I feel come back on their estimating us just because you know, we're not international riders Um, and I think that's the best way for for county riders to get, you know, big results Myself personally, I'm not a sprinter. I haven't got that, you know, kick at the finish So I'm unlikely to get up and and bond sprints. So realistically speaking, you know that that long breakaway or The late breakaway is probably the best chance of getting getting up early now How technology develops you say it in motorsport, but it's also in the cycling world We've got this bike beside us That you're going to use Yes On on the race and you've been training hard on it. What makes this bike so special rona? Well, it is the latest technology But at the same time it's kind of gone back to to not the basics But back in time we but and that it's a bike that's custom made for myself you know every bike I've had from Trek to specialize to dole and to planet X's to panarellos They're all off the peg, you know the size that the The top level world champions and professionals will be getting to be the same size that the customer buys in shop This one is made exactly the way I wanted it So everything from the length of each tube to the angle of each tube to the stiffness ratio of the head tubes in the The rear triangle and that absolutely everything is custom custom made So 51 bikes came to me at start of the year and says What would you like or what do you think would give you the best chance? I basically said to them that I wanted the lightest and stuff as bike I've ever had to be the most comfortable bike ever ridden and I wanted it to be like Basically accelerated like nothing I've ever had before and they've managed to put it all together like and then the paint job is Inspired by another rona McLaughlin the photographer from uh, he has a picture Mount head and the northern lights above Mount head and And that's where we the inspiration for the paint job came from Some of the big names and Irish cyclins on it Roach There's uh, I'm still a wee bit uneasy about that, but it's for more motivation. Like it's all Irish winners of the Ross I don't think I'm going to join the name of actual overall winners or join the list of overall winners, but Uh, you know to have some of those names that now you have Stephen Roach of Cure on par Stephen Gallagher Uh, some massive names on there like and you know every little helps So is this the best bike that that you've ever taken on that competition or is I I think it's the best bike for me without a shadow without because it fits me every bike I've had previously was either too short on top or too high on top or whatever And for me personally speaking, this is I got on it last week and it just straight away It was like, oh my god, I should have only these years ago So but then again, they weren't they weren't available years ago They are just they are just new to the market there and it's it's working for me so far Let's talk about stages then uh Nearly 500 kilometers is going to be based in Donegal. We're going to flat Paces in Donegal. There's a lot of hills in there as as as we know no flat as as we know they can't do well But Bondour and Bunkrana down low and Donegal town are all are all stage finishes What's going to make Donegal so special this year and and the rest and what's going to be such a huge Contributive factor and who's going to win this is going to have a have a have a big scene They're stages that you know well Sean looking forward to them Looking forward to them, you know, I'm supposed to look forward because we can and know them and we know where to Maybe move up in the bunch, you know, because in bike racing if you're you're too far back and in the bottom of a climb It's very very rare that you'll be shelled out the back So we know them very well myself and Ronan and the boys that's on the team that's been wrecking them So we'll be able to move up hopefully and get well well placed in the bunch before we hit the bottom of the claims You know, it's not going to be easy for like myself and maybe all the smaller counter riders But like Ronan them like they'll be moving up because they'll know them really well and they'll know the tax are going to be Placed, you know, a likes of my more claying action And we're in Carrick and Calcare It's not no place for faint hearted I think it's I think it's the Wednesday stage that there's three claims towards then before you're going to Bunkrana with my more being the last one of them If I'm right like that's serious stuff on a bike sort of that last 40 kilometers from when we first go through Bunkrana until we get back to Bunkrana for the finish It could be the hardest 40k the whole the whole risk like and it could actually decide the whole risk Um, we you have Glenn Gage on stage six, but it comes very early in the stage it might be more just of a Waddling down process on Glenn Gage rather than actually a deciding factor for the risks like my more could be um, but like I I wrecked stage five there a few weeks ago from from Bunkrana to Dunlow and You know, you've got the the main road from Bunkrana to Larry Kenny, which probably everybody knows but from the second you Turn out at Milford It's small roads all the up and down left and right all along the coast If it's if it's a morning like this morning where there's one than rain That could be on paper that looks like one of the easier stages But it could really be a decisive stage if if it is like that How are these stages affect some of the teams that we mentioned earlier on at the start because there's some of the Big names and and cycling that are going to be coming here to to the county and how these stages going to Impact these guys or the sort of thing that they like to be challenged on definitely, you know, you have I think any teams coming this year will bring climbers their best climbers to kind of they'll have looked at the route beforehand On the gps profiles and all that we have and they'll see that it is a hilly Ross Um, so they'll bring riders to suit that kind of terrain um, but then again, you know Irish or the Irish riders knowing the roads will be an advantage and Um, as I said at the at the launch of the wrist, like it's it's all very well been You know one of the best climbers going up one more gap But if you happen to meet a sheep coming down the other side, it could be could be a whole different story You know, and if they're not like that's actually one of the scary things for me for the week Is that I know coming down that straight said a memorial for the descent that if you got the top And you don't know it. It just looks like a straight road. You go down under k and r But for me and john knowing it and knowing how bad the surface is and knowing that there is sheep everywhere and Yeah, uh, it's not just as straightforward as it looks and We're gonna just touch and rally and boost vasty lobe came here in 07 He was the world champion and it took him Over a day just to get used to the donigal stages Is that similar and and cycling because use boys know What's happening at the at the local knowledge can give you a wee bit again Maybe when it first comes to the county show Definitely with our local knowledge is going to play a big part for us like, you know And I suppose not for maybe professional bike riders like team wagons and all them They've raced on all sorts of roads, you know, me like so As we only said though that that that road from Bunkana to down low when we go for knock out and then to Over the fan of bridge if the ones blowing like it was today Like there's going to cross one there and it's going to be split the pieces I think from from down low across or from The blaney bridge across like it's but we're kind of blessed. I suppose in donigal this year because They're really all on good roads. There's no back roads. It's all good roads that we're going to be on So it's kind of a bonus to us here when they like when we done the row when I've done the last previous Down round carry and claring in all I was all back roads, you know, but we're very lucky They were going to be on the main road from From Bunkana to down low. There's no back road at all, you know And then suppose when we hit glentes to head it back over to donigal town From donigal town back down the rd I think we'll go and cross country and that's probably where it's going to get tricky again because we're all on by roads there heading back to To rd back from rd back to scurry again. So that's going to play a big part again there There's a huge factor as well that enter nice on teams coming from europe especially You're not used to the side road that we ride on or drive on that is a factor as well And we've also got cat's eyes, which a lot of them wouldn't be used to so the first few days There is a lot of crashes now that are caused by both those factors and again, it's just not knowing our roads And you have to be very careful to to avoid these crashes because it happens so quick Well, that's I can ruin your entire race. The worst nightmare is, you know, putting a year's effort into You know, we're trying to do absolutely everything right and maybe crashing the first day Yeah, and that can't happen and those happen This is a huge event and it's great to see it back in donigal after a five-year absence But I'm sure if locals get out onto the side of the road and follow the rush around the county The likes of you sports we'll get a huge left of it Definitely, you know, we'll have a lot of local support like and It's great that we I know myself personally I get so much support the whole year like if There's a I couldn't really mention them all now We did a lot of people in four of the second club and at home my parents and my family and all that Helped me and take me everywhere and that makes a massive difference And now that'll all be multiplied 10 fold next week because the fact we're both from donigal Anybody out in the roads from donigal, I assume will be supporting us and cheering us on and Writing on the roads or having flags or banners or whatever they can it really really does help like Yeah, I suppose a wee bit more special for you too, Sean that given that you've put this package together with such a A low budget a limited budget and and trying just to get to the start line So when you can't get out there and can't compete when you see everybody that is back to this Last number of years and particularly his last number of weeks It'll I'll make it I suppose with more sense of achievement on it that you're on it I would all like you know, I mean as I say my wife's a school teacher and my son's in the school in a local school here And they're going to be out everywhere in the course and you have to hand it to the rest like they go through The towns before that and hand out t-shirts and balloons and banners for all the all the all the schools and we're passing through Let it Kenny. We're passing through a lot of schools. So it's going to be good It's going to be a great week and hopefully we get the same weather we got in 2012 and make it enjoyable for the spectators Like in 2012 when I come over in my more it was like 25 degrees like it was It was a spectacle like to see the crowd that was on it though. So like We've done our best We've we've got the team ready. We're ready to go and fingers crossed that we can make it from Dumbbell and castle back to scary's in one piece. That's my final question to you show what Where do you want to be at the end of the race? What's what's your target now for for this for this race? Target is to as I say starting Dumbbell and Castle and financing scary's and get back in one piece They have a holiday to go on the following week. I'm going to Dubai for a week So I don't want to go with any broken bones or anything. So the bike will be left at home The bikes can be left at home and the runners and everything's gonna be left at home But no listen, I have to I suppose thank a few people like the people that's coming out to help me They're all volunteers and uh We're gonna give her a best shot like self jesse mckew jordan McGinley Sean McBride duck at all If I've got somebody I'll millie and I suppose Jason for the for the captain stuff like that So we'll give it a best shot as a as I don't think all team as I don't think all base team And we've heard that the rest is coming back to don't go For the next two or three years. So hopefully we may be able to build on that and maybe Get the legs of Ronan on board and get the character boys on board and build a proper don't think all county team Again and and have another stab at it like yeah, and for your owner What's what's the the hopes now for for the rest where do you want to become the funnest later on? What do you want to get out of it? Yeah, I do have two goals. We've spoke about the stage one Um, I am trying to go for the best overall position I can as well. Um, which is maybe more achievable than a stage one Um, but if we get that stage one, I might not even start the next day That might just be it done like, you know, it might not top that so if I forget in the first day, you might not even see me until I go No, that's you know, that's that's the goal for the week is to you know, obviously to get around in one piece first and foremost like and that's that's You to achieve anything you have to do that to start with And then stage one and overall is It's it's the first roster. I'm actually coming out and saying those things and in the open that that's what I want to do Like so I'm I'm thinking Well, I know I'm I'm ready to achieve those things, but you still need a bit of luck. So, you know Well, we can do is first the two years the very best look with with the rest next week and hope you uh all your goals Calm as far as both of your respective teams and you get what you want out of the event and all fingers crossed That'll be a a huge one for for for the county and predictor for years to you boys Thanks for coming on and all the best next week in the roster. Thank you


Alright guys, so welcome to today's video. Today's technique is gonna be a hair color technique. Super excited to share this with you guys. I did this haircut, it's the Bob haircut with the really fun kind of point in the back. So if you haven't seen that haircut, you can check it out on YouTube. It's only a couple videos ago. So today I decided I wanted to color that mannequin and really just kind of bring out the technique. So the tricky thing about coloring a bob is the fact that it has this graduation in the back. So if you're not just doing one color, you're doing any kind of foil work. You don't wanna get the foils into this part of the hair because it'll just look spotty. So this technique is catered to that. We follow it, we work with the head shape. It adds this brightness in here and really pops the brightness in the face as well. It really just brings out the haircut shape. I mean, if you look at it now, you could see the kind of red depth that we put into it and then also that brightness in the front. So I'm gonna show you guys how to do it step by step. I don't wanna waste any more time. So if you have any questions, post them in the comments below. If you haven't subscribed to this channel, make sure you subscribe because I'm putting out videos all the time and I'd love to have you a part of this community. So thank you guys so much for watching. Let's get started. So the first thing I wanna get into with this technique is the sectioning. Sectioning this office is kind of the most important part about the technique. I'm really just following the hairline. So this is a new sectioning technique that I've been playing around with because the head shape is so important. And I've talked about that in a lot of videos, but also the hairline is really important and it plays a lot of role, a big key role in the density of the hair. So I follow that hairline all the way around, creates kind of like a square section on the top. We clip that away. And then I take a diagonal forward parting from the point of that square down to behind the ear and that sections off the front of the face. So we're gonna be using the Joico Blonde Life Lightener. This lifts up to nine levels. That's not what I'm going for in this technique. Really, I just wanna pop some highlights into the front because I'm gonna overlay it with one tone. But because I'm putting highlights in it, it's gonna give me that depth and dimension throughout the technique.  I chose the slices because it's a little bit more prominent and I really wanted to kick that brightness up in the front of the hair. So I take a slice, I cut that in half. It's a baby fine section or parting and then I slide the foil up underneath and I paint the Blonde Life Lightener with the 30 volume on there. So I'm gonna work my way up all the way around the front of the hair, all the way up to the part and then I'm gonna do the same thing on the opposite side. I'm gonna speed this up so it's a little bit easier for you guys to consume. So enjoy. All right, so you guys can see that placement, that diagonal forward placement. I'm sure you can imagine it's gonna pop that brightness right in the front. And I'm gonna go in with these six RR with a dash of four RR. This is Joyco Lumishine Demi Permanent Liquid Hair Color with five volume developer. I'm gonna place that all over the hair. Now because we saturated our entire head with the same tone, those foils really come into play to pop just a little bit different tone into the front. So I wasn't trying to lift her super high so you can see how that square falls over and that brightness sits right around her face. It changed the overall tone of her hair to more of a red tone. Just looks really rich, nice, beautiful color. Hope you like it. Let me know if you have any questions in the comments below. Thanks for watching.


Hello, my name is Ayush Krishna. I've secured all India ranks 6 in Indian Forest Services. This is my third attempt and this was In the third attempt I was able to qualify the blimps for Forest Services for the first time. I just gave a brief about myself. In 2019 I gave my first attempt where I was able to qualify the blimps for CSE, not for the Forest and I gave mains and was able to reach till interview but I could not get selected in the first attempt. In the second attempt I could not qualify the blimps itself but in the third attempt I was able to qualify blimps for Forest Services as well as Civil Services. In Civil Services mains I could not qualify but in Forest Services I was able to score all India ranks 6. So I have also given this 2022 attempt and I was able to qualify both the blimps of Forest Services and Civil Services. And I will be giving this win. So this is a brief journey which I have shared and apart from that I had a session in Sankar IS-1-1 particularly Karthikeyan said the most important part which I feel about Karthikeyan says like he gives emphasis to what you are lacking. It's not just a ready-made thing but it's a thing that is made for you which I personally feel because there were few points in the interview which I feel I got benefited because there were questions on Rai No Ghaziranga National Park which I had discussion with him and also about the flood situations. Though it may sounds obvious but that discussion makes a difference how I am going to respond because there were few topics which I was not able to comprehend but with guidance of him I was able to do that. Otherwise also I was a part of Sankar IS in terms of mock interview. So overall it was a good experience because when talking to teachers like Karthikeyan said because he has so much experience from other candidates also. So it was not a value addition to me only. It helped me from so many other students experiences also. So I would like to thank Sankar IS for this opportunity to speak and also giving the time to me for this. I would also particularly like to thank Karthikeyan sir because I am really benefited from it and I look forward to get his guidance in further coming mains also. Thank you very much. Thank you.


Welcome to The Crimson Engine. Today we are looking at the secret weapon of the cinematographer which really involves going to the location beforehand and lighting the scene, also known as the pre-light. So how do we shoot Neon Noir's 22 pages in just two days on a weekend? We had five locations to go to, each of which was about a 30-minute drive from one another, so we knew we were going to lose about 90 minutes just in travel time. Also we were shooting a lot of this for free so we couldn't ask people to show up at 6am, we had an 8 o'clock and a 9 o'clock call time. The secret for us to get through the days was what's called a pre-light, which means getting the location before you're going to shoot there, going there with the lights and the camera if possible, lighting the scene, experimenting with how it looks, getting it to 90% of what you want and then leaving, coming back the day you're going to shoot, turning the lights on and shooting.  So the scene was six pages long, which is going to translate into about six minutes of screen time, it was just two people at a table but six pages is actually quite a lot of dialogue, six pages is longer than a lot of actual short films and we weren't going to get a chance to rehearse beforehand, so we're only going to have from about 2pm to about 6pm to shoot this scene. How I mitigated that rush was to get access to the space on the Thursday beforehand, go there with the lights or light it. Film Gear, which is a company here in Los Angeles, were kind enough to let us use their warehouse that was full of lights and were able to use their lights to light the scene, we didn't have to transport the lights there and take them away again, they were already in the warehouse. Me and an assistant about three and a half hours to set up the lights to get them all rigged, to get them looking the way that I wanted them to, the added advantage was that because we're shooting on the C200, which I own, I could bring it with me, I could shoot my assistant as a stand-in and then take that back to the studio, tweak the grade, look what I was getting in not just in camera but on the computer and then make adjustments for that when we went back to shoot on the Sunday. So all in all we saved three and a half hours at least of shooting because we didn't just need to light the scene, we needed to get up into the rafters of the warehouse and black out the sunlight coming in so that it wouldn't wash out the contrast I was going to create. So we got there at two, we still had to kind of like block and set up and do makeup and tweak the lights and set up the camera for about an hour. So we got there at two, we didn't, we shut from about three to about five, 36 o'clock I believe. Had we not done the pre-light we would have been there till nine, 10 o'clock at night, which wasn't really an option since FilmGear was letting us use their warehouse and paying for their employees to be there. I didn't want to ask that from them. So the key in the scene was a four bank fluorescent light that FilmGear makes that we suspended overhead of a table with two C-stand arms and a little bit of jerry-reaking. We had this all the way up, it is dimmable and we used the table itself as bounce. When we pushed in on some of the close-ups we then brought in a white card to add a little bit more bounce and a little bit more light to the eyes. Then we added a three quarter scratch with these lights behind both of the actors and we gelled them blue to create a color contrast with the daylight balanced key. The other lights we put in here were background lights, these were LED fresnels that are really really bright and we put them right down the end of the warehouse pointing them actually towards camera so that they illuminated the shelves and the stuff on the shelves and gave it this really great sense of depth and sense of space. When you're shooting a short film it can be very easy for the film to kind of take on a white wall syndrome where it looks like you're just shooting in the same small little confined spaces so to have this space that was really big and vast and came pre-dressed was a huge advantage and I think it added a lot to the scene, added a lot to the film. Thank you again to FilmGear for both the use of the space and the use of their lights. For the quality and the range they have they're very affordable. The link to FilmGear's lights and the other stuff we used on set is in the description. Neonua has come a long way. We have a fine cut now, just need to tweak a few more things before we lock picture and start on their mixing and the music. Hopefully fingers crossed we'll have something to show before Christmas. I'd like to hear from you guys whether or not you find pre-lights useful if you've used them. Often it's not an option because you only have the location or the equipment for the day of the shoot given what rental prices are. Thank you very much for watching. Subscribe if you want videos like this. I've started making blog posts that accompany my YouTube posts. You'll find the link in the description on CrimsonEngine.com. Thanks very much for watching and I will see you next time.


What's up everybody? Jason here for jaspercaserace.com 2021 Panini National Treasures football first off the line One box break Pikachu number five just sold out guys. So this is first off the line guys They do sell them in cases, but for the most part, they're usually loose and this is a loose box We have two loose boxes in stock. It looks like so the next one for number six is on the website So we'll determine which box we use here for this break, but again, we had a 17 team random number blocks. So everybody has a piece of all of these teams here As you can see right there and then obviously thank you to everybody else that bought in straight up as well Now like I said, it is two loose boxes All right, so we'll go left right One two three for the left four five six for the right Three one two three So there you go, this one will be for the next one quick break, but a very monstrous break potentially first off the line Bases loaded for the G-men But it was he got this Thick box maybe a book in here. So you get one stars and stripe RPA plus a stars and stripe Stars and stripe are base part I should say Here's the first Travis Kelsey 9 out of 13 Kansas cheese Paul Norton straight up and a one-of-one. Wow Super Bowl Randy White Super Bowl immortality That's pretty nice Dallas Cowboys That's part of the 17 team R&B and Carl. There you go, buddy on the board with a one-of-one spot one Ronald Jones for the Bucks 1099 99 of 99 That's hand with the Bucks straight up short-handed Who scored that was that my David? No, somebody else can't see Hyman Randy Moss Justin Jefferson dual combo for the Minnesota Vikings that's Steven flat and Jonathan Taylor Indianapolis Colts Jimmy as well All right, and last relic here is Pat freer month 26 out of 49 for the Steelers Patrick Evans with a Pittsburgh Steelers Good luck guys. Here we go First one is Kylan Hill for the Green Bay Packers. That's 15 out of 20 15 out of 32. Sorry It's Green Bay Packers Carl a spot 5 We have a true RPA of Chuba Hubbard 25 out of 99 just a little single-color patch and that is Well, they're scored. It's our Panthers 17 team R&B spot 5 another one for Carl man. Damn Carl's getting one and five so far we have Joe Thomas 22 out of 25 Spot two, maybe Brown's no Mike straight up and last one here is a Stars and Stripes RPA 8 out of 10 three-color patch Kyle Trask That's going to the Buggineers and Han All right, nice So nice little RPA there for a quarterback not the best quarterback, but a nice quarterback RPA at a 10 So there you go So we have one more loose box guys You guys want to try to get it going for tomorrow? Appreciate it everybody Jaspie's case breaks calm. So a couple hits here for the random number block I believe they all went to Carl spot five spot five and one of one Then like I said a Kyle Trask RPA. We got a Joe Thomas autograph Pat Fremont dual patch dual relic of Jefferson and Granny Moss from the Taylor Ronald Jones and Travis Kelsey So there you go guys appreciate everybody Jaspie's case breaks calm


Hi, my name is Timos Fauzi. I'm a research associate at SEI Asia based in Bangkok, Thailand. I'm working for a policy cluster here and my work revolves around the intersections between policies and natural resources, climate change and environmental issues, especially across Southeast Asia. Thinking cities occur when cities are flooded because of mainly two reasons. One is because of climate-induced sea level rise and secondly, it's because of the excessive groundwater extraction as well as massive urban development. So Jakarta in Indonesia can be one of the examples of the same cities in Southeast Asia. The reason being Jakarta is facing this climate-induced sea level rise also on the land subsidence due to the massive urban development as well as excessive groundwater extraction. So I think policy makers should focus their attention to addressing the root causes of the singing cities itself. They should strengthen their climate commitments to mitigate the adverse impact of climate change and for one thing. The other thing that they can do is to improve the urban water service for the cities so people will have less reliance on groundwater for their water needs. I silently praise people who bring their thought-backs to the grocery stores.


Hello there, it's Mr. P. On today's lesson, we're going to look at expletive sentences, like in the following examples. It is sunny and hot today. There was a problem. Here comes the rain. Let's get started. Grammatically complete sentences contain a subject, which generally takes the form of a pronoun, a noun or a noun phrase. An imperative sentence, however, is written without its understood subject, which is you. Let's look at these examples. My best friend is a nutritionist. My best friend is a noun phrase. He works at a school. He here is the pronoun. Instead, eat plenty of fruits and vegetables. Here is an imperative sentence, so you is understood. To identify the subject of a sentence, find the verb and then use it in a question beginning with who or what, as shown in the following examples. Mary works at a school. Verb works. Who works? Mary. So the subject then is Mary. Eggs contain cholesterol. Verb contain. What contain cholesterol? Eggs. So the subject is eggs. So let's look at it, there and here then. Let's start with it. It is a pronoun and is followed by the verb to be and an adjective, like in this example. It is called outside, called is the adjective. It can also be used with the verb to be, plus an adjective, plus the verb, plus ing, like in this example. It is nice being here with you. So it is the pronoun, the verb to be is, adjective nice, and then we have the verb be being, ing, and then the rest. So it can also be used with times, like in these examples. It is five o'clock, it is Saturday. It can also be used for weather conditions, like it is sunny, it is warm. It is also used with distances, it is six kilometers, it is far. It can also be used with who. For example, on the phone, it is me, it is my friend. It can also be used with expressions, such as, it looks as if it will rain. It takes one hour to get to Ottawa. It seems absurd. It can also be used for the passive. The passive is the verb to be, plus a past participle verb. Like in these examples, it is said she speaks good English. It was seen by a police officer. Now let's look at there. There means here as an adverb. For example, your pen is there. The second usage of there is as a pronoun, and there here has no meaning. For example, there is a pen on the table. It's the same as saying a pen is on the table. So we'll call it the dummy there. Dummy there needs the verb to be, plus a noun or a noun phrase. It can also be used with would, might, can, will, have, plus the verb to be. Or it can also be used with other verbs, such as seen, happen, tend, plus the verb to be. There can also be used with other verbs. But it gives a more literary feel, like in this example. Later, there came a truly marvelous painting. So let's look at how there can be used formally or informally. The first one is the correct way, like in this example. There are three pens on the desk. So we say three pens, and that's plural. So that's why we need are. There are three pens on the desk. And this is formally. And it is correct. However, some people say there is three pens on the desk informally. Even though the number is three, they use the singular form is, there is. So let's look at here now. We can use here as an exclamation, like here. Let me hold it. Here can also be used as an adverb, and it is used when introducing something or somebody. Here is your pen. Your book is here. We use here, plus the verb, plus a noun or a noun phrase. For example, here comes the teacher, so the teacher would be your subject. Instead with a noun phrase, here was a great civilization. Some sentences begin with an expletive, there, here, or it. Such a word occurs in the subject position, forcing the true subject to follow the verb. There were many books in the library we visited. So there is your expletive, where is your verb? When many books is your subject, a subject following the expletive, it, is often a clause rather than a phrase, like in this example. It is impressive that children learn to wait. It is your expletive, is, is your verb. That children learn to wait is your subject. In sentences beginning with the expletive, there, the verb comes before the subject. The verb are is often hard to hear when it follows there. So be careful that you don't omit it. There are certain people with skill sets. So let's take a look at some examples. There are seven chairs around that dining table. It is the dean of the school who maintains the discipline. It is extreme bliss that has some reaching for another cup of tea. Here comes our new principle. So that's it for today. If you have any questions about this lesson, please post your question below the video. If you haven't subscribed to my channel, I suggest you do. If you liked the lesson, hit on the like button please and you may share the lesson if you liked it. Thanks for watching and I see you next time with a new video lesson. Until next time, bye-bye.


On Wednesday, the International Well-Building Institute announced that Yankee Stadium is the first sports and entertainment venue in the world to achieve the Well Health Safety Rating for Facility Operations and Management. The Yankees have fulfilled rating requirements that serve as a blueprint for best operating procedures to help fight COVID-19 while also providing world-class standards for overall health and safety. Here's Chris Sheeran with Yankee Senior Vice President of Stadium Operations, Doug Beha. Are there any specific things that you've installed to mitigate the risk of COVID-19? Because I know a bubble situation has been talked about come playoff time and New York could be one of those bubbles. So have you done anything specifically to mitigate the risk? Yes. Thanks, Chris. One of the things that we did, we thought on top of our traditional cleaning and disinfection, if you will, we thought what were the best ways for us to provide some sort of disinfection at the appropriate levels in the important spaces that was non-invasive that we could do 24-7. And what we landed on was a few things. And we actually first started and installed down in our spring training facility down in Tampa and of course in our Himes complex as well, a low-dose hydrogen peroxide system that basically goes in duct in our HVAC and it creates a low-dose hydrogen peroxide that kills bacteria and pathogens in the air. It's obviously safe to people used in hospitals. And we thought this was a good way to keep that going while our folks were in their trainer's room, in the locker room, in the weight room. All of the player areas or if you're familiar obviously with the Tier 1, Tier 2 with MLB in all of those spaces. So the umpires room, any place where a Tier 1 or Tier 2 individual would be, we've put that in place to really help mitigate any possibility. Are there any other specific protocols besides that in designated areas for players like the clubhouse or the dugout? You know, the Brian Cashman staff has been great and has embraced these protocols from the very beginning. When we first started kind of developing this, we sat down with his entire team, his medical staff, you know, the clubhouse staff, anybody involved in this process and walked through what that could look like. We felt like we needed to engage everybody on this, go beyond what maybe just the housekeeping staff would do at night or in the morning. So the protocols we have in place where everybody involved, whether it's the strength coach or a head athletic trainer or clubhouse manager, are all involved in wiping down of surfaces, frequently touched surfaces as well, things that the players may use. Our players have been great in supporting that and participating that as well. So we've added those elements to what we thought was already a good kind of program and feel like we've taken it a little bit further. And Doug, one more. How long do you expect to have those facility enhancements in place? You know, for us, it seems too logical to not keep those in place forever. We're talking about cleaning and disinfection. As Rachel mentioned, this just kind of goes beyond just COVID-19. We have flu season upon us.  It's safe enough for us to do. It's something that we see being in place for the future.


All right. Hey, Bama listen up. This is coach capstone here And I'm here to help you have a safe and enjoyable game day by walking you through some of my favorite football watch party Formations, okay, so y'all listen up and pay attention All right y'all formation number one. This is the ISO formation. All right ISO as in isolation All right in this formation you're going to be by yourself Or maybe with a roommate or two, but not too many people. Okay, you're just gonna be wide open Okay, so wide open that our friends from the sec east might be able to hit you with a pass. All right All right formation number two.  Okay, you're gonna get on a zoom call and the best part about this is look You're with your friends, but you can mute the other people if they get annoying so the wing Z. All right We got the spread formation, but right now we're not trying to spread anything Okay, so we're gonna prevent the spread in this formation.  Okay your mask and you're gonna watch the tide row All right y'all look these are just a few good ways to stay safe and watch Bama play this fall Okay, so where your mask stay six feet apart and make sure you don't have too many players on the field Okay, because if you got too many players on the field excessive celebration, we're gonna get a penalty All right, and my job is to keep you in the game. Okay, so follow the process where you mask and roll time


Awesome. Glad to sort that into your ministry. And yesterday I spoke on glory when heaven invades earth. Who can I give this copy to? It pays to sit on the front row. Okay. And today's message note, the Lord has changed my direction for this morning. So I'm going a different direction. God's still writing your story. It's the book that touches this one. Bro, I can't get Naomi off my mind. You're helping me. Thank you. That's going to help me right there. When you're reading the story, you're actually not reading a world story. You're reading Naomi's story. It's a redemption story. And Naomi is this woman who suffers incredible losses and then comes through a horrific grieving season and work on restores her fortunes. So that at the end of the book, Ruth is married to the rich guy. And they've produced it so bad.  But at the end of her life at the end of the story. So it goes from that she has, she had, she loses her husband, she loses her two sons. So at the end of the story, she is nursing. Oh, it has given a son to Obed. And when you look at the story as a progress, as it ends, you're just like that one of a redemption story. I mean, she lost her husband, she lost her sons. And okay, so she's nursing Obed, you know, but, but not really a redemption story. 50 years later, they're 50 years later, somebody looks at David on the throne and they go, wait a minute, she's in the Bible and there's many in the room here that you have been, it's as you're looking at, you're like, you know, this just doesn't look so good right here. And life is over. Where is this going to see what God is doing pursuit has been in my tragedy. 77, my spirit goes into this diligent searching mode. God, what are you doing? What are, what, what, what are you saying here? What are you seeing? What are you speaking over my life? Where is this going? What is your purpose? Why have you allowed all these forces to wreak havoc in my life? And your spirit is searching diligently for divine person. It's been my journey for 27 years. And I'm just going to share some stuff from the overflow that see what's, see what God rewrites that narrative. Has anybody here think that happened in your family?  Let me tell you about this, this, and this. We were protecting you, tight the story and giving praise for his God actually enters into the accusations of the enemy and speaks accusation against God. And so we want to pursue the faith. Paul said it twice to Timothy. He said pursue faith. Pursuit, I know that's your pursuit. We're in a violent pursuit of faith. Let's pray. Heavenly Father, as we come to the word of God today, I'm asking that you would give us eyes to see what you are doing or to your activity, to your purpose and to your heart. My circumstance in my job sent out to us as this. They gave the children of Israel, which we have gone. They step into Canaan. And now there's more funerals. God is already fighting for us. And they're going like, don't you remember what God promised us? He said that he would cut them off. He said that he would send hornets and God is all and so the eyes of faith, but is with us. God has forced on what is against us. This is the 10 in unbelief are going. God has set us up for failure. The two in faith are going. God has set us up for our inheritance through the tragedy, through the trauma was doing in Naomi's life until 150 years later. And we're going, oh, it really was a redemption story. Lord Jesus, give us eyes of faith. I'm asking Lord, would you help us to see what you're about your holy purpose, the trials and circumstances, how Joseph had to find us when you're in prison. Joseph was 17 years old. It's as though the Lord says, damn, way to go, bro. Man, you're separate from your generation. You're holding your heart before me. Joseph, congratulations, bro. You get a promotion to slavery. You go to prison. He's himself in slavery in Egypt and he's just faithful and both of these gifts and his talents and God comes to this young was Joseph. Good job, man. You're faithful to cultivate your gifts and talents. And you said, notable, you get another promotion in the kingdom to prison.  Sure. This prison is definitely his God like, and so Joseph in his prison, he's like, you know what, I'm just going to study dream language, like dream interpretation through dreams because he's desperate to understand his dreams in the middle of his prison, but gets him out of prison when he's now able to interpret their dreams. And then when Pharaoh gets a dream, now he's able to interpret Pharaoh's dream. And the thing was knowing his God study at Joseph is in a prison where he's going deep into the heart of God because he just cannot, it's happening to him and he starts pressing deep that everything he touched turned to gold. You know, he's got the people skills. He's got the admin skills. He's got the money skills and the accounting skills.  And he's got the whole, he's even good looking if you know what I mean. He's just got the whole package and he's got it burning on all burners. And everything he's touched and turning to gold and God comes to this five-tailed kid who's got it burning on all burners and goes, Joseph, you're good, but you're not good enough. Leave you uninterrupted, ever discovered that here's the weakness of a service without the Holy Spirit. You know what I'm saying?    When you're in prison, I don't care what your people's skills are like. They're not going to get you out of this prison.  It's not going to get you out of this prison. I don't care about how strong your business skills are. They're not going to get you out of this prison. And Joseph finds himself in a context where every talent that he had ever cultivated and made fruitful in the kingdom of God. Well, God's like, son, you got to go deep. And there is a dimension in the Holy Spirit that is not by talent. It is not by gifting. It is not by strength. That is not by might. It is not by power, but it is by my spirit, says the Lord. Find the spirit, things that we rely on to force us to go deep into the heart of God that is beyond our giftings. Joseph, you're good.  To that destiny, you've got to find a dimension that goes beyond your gifts and talents, not by might or power. Spirit, says the Lord. God's looking at Joseph's prison in a different way than Joseph is. And Joseph is trying to find one of the passages that really helps me with God's perspective on Joseph's prison is Psalm 105. I love this portion where God is giving his perspective. So it's prison, Psalm 105 or 16. Moreover, he called for a famine in the land. He destroyed all the provision of bread. He sent a man before them, Joseph, who was sold as a slave. Verse 17, just yet, but verse 17 says that God sent Joseph ahead of the brothers and sold him as a slave. Now, when you read Genesis, it doesn't read like that. When you read the story in Genesis, his brothers did it to him. But when you read in Psalm 105, God goes, actually, it was me, Joseph, as long as you have your eyes on what your brothers did to you, you will remain a prisoner to their rejection. But if you can lift your eyes to what God is doing in your life and see from heaven's perspective, you will become a player in a drama that it's going to become the best, one of the best stories in all of scripture. I'm not sure. I think they're working to find it for her stream. Verse 18, they hurt his feet with fetters. He was laid in irons until the time that his word came to pass, the word of the Lord tested him. The king sent and released him. The ruler of the people let him go free. He made him Lord of his house and ruler of all his possessions to bind his princess at his pleasure and teach his elders wisdom. I'm going to ask them just to keep that scripture on the screen for us. For Joseph came out of prison with the authority people in the very prison that he once was in. So when he imprisoned his brothers, he's putting them in the very prison that he was in himself.  Joseph came out of prison. The case to that prison. Hey my friend, you're coming out. I'm in. He'll be staying in. Joseph came out of prison. He came out with authority over the very prison that held him. I believe God wants to give you the same experience in your imprisonment.  Never relent until you hold in your hand the keys to the prison that now holds you. Unbelief looks at Joseph's prison and goes, you know what? It doesn't even pay to believe. It doesn't even pay to cultivate your gifts and say no to temptation. You end up in prison anyways. Looks at the Joseph prison and goes, God's preparing a vessel who will become a feeder of Lord, give me eyes to see. When I'm telling you when you're in a prison, you need eyes of faith to see what God is doing. Lord, give it to us. We pray. Here's someone else that informs me on this. Caleb. Caleb is the God. The two of them. Caleb and Joshua were in faith. And so Caleb, he goes into the promised land. He comes back. He's like, guys, we can do this. God is with us. He's got faith to go in and take the land. Because of the unbelief of the people, Caleb does 40 years in a wilderness down fear. That's a raw deal. Caleb has the faith to go in, but because they don't, he's got to do 40 years in the wilderness with them. Don't you look at the Caleb story. I'm looking at the Caleb story a second time. They come through the 40 years in the wilderness. There's five years of taking the land. It's now 45 years later, everybody and inheritance. You get a house in a field. There you go. Sis, God bless you. Hey, bro, house in the field. There you go. Go, go, go, hey, man. House in a field. There you go. God bless you. Hey, sister. House in a field. It's Caleb's turn. Caleb got a house in a field. Wanted a house in a field 45 years ago. Wanted 45 years ago. I've just come through a 40 year wilderness. Count them 40 years. Dust filled, viper enhanced, scorpion enriched 40 years. He says, I no longer want what I wanted 45 years ago because the wilderness changes what you ask for. He's like, I want more. I want a mountain. Somebody goes, well, who does Caleb think he is asking for a mountain? We just got a house in a field. Why does Caleb get a mountain? Actually, nobody complains. Caleb wants a mountain because he did the time 40 year wilderness. You are buying. You're buying authority with people and with heaven to take a home done of God. This Caleb, I love you, man. You're my kind of guy. I love your passion. I love your devotion. I love your faith. I love your, your, your diligence. Caleb, I want to give you, um, if I give it to you on this side of the wilderness, the nation will be in an uproar. So work with me here. Just do 40 years. If you will endure in faith for the next 40 years, then you have endured 40 years. You will have an authority with the entire nation and authority with heaven to ask for and to take wilderness and they go like this. Well, if you had more faith, you wouldn't still be in this wilderness. 40 year wilderness because of his faith and a share with you for keys to waiting on God from the life of Caleb. I find something to write this down. Okay, borrow a pan, borrow, get out a device, punch it into a, into a device or something. Find some way to write these four things down for keys to waiting on God from Caleb's life. You're going to want to keep this. Don't exist. Mothers and fathers are beyond Michigan at this conference. We need it in America. We need in this land today, men and women that will walk a journey with God that will endure a wilderness and will actually buy the authority in the kingdom so that they can take a whole mountain in the grace of God. God, give us some Caleb who will endure a wilderness so that they are so enriched that they have something to give to another generation. Do you look at Caleb's wilderness through the eyes of unbelief and you're looking at that thing going, yeah, it doesn't even pay to have faith to go in. You're still going to have to do 40 years. The eyes of faith look at it going, he's buying authority to take a mountain. A little bit distracted by the cross at this time of year. Easter Sunday morning does not quite scratch my itch quite enough. I just get distracted with the cross and it's on my radar. What do you see when you look at the cross, what the world sees? Cosmic child, if you believe the eye of cynicism looks at that through a critical lens, but we look at the cross through eyes of faith. We see the father giving his son a gift of cosmic purple cross. I see the balance beam of Christianity. Every imbalanced doctrine has moved away from the cross and the cross is always inviting us to come back to the center. When I look at the cross, I see the anchor of our faith because when your faith is being shaken in a storm, there's really only one thing that can anchor your faith in a faith crisis and that is the cross of Jesus Christ. When I look at the cross, I'm looking at my GPS because when I don't know my way forward, when I don't know which way to go, the cross tells me you walk the Via Dolorosa. The cross is the emblem of my faith. Now there are some, I had a brother one time, he said to me, I don't think we should make the cross the emblem of our faith. He said, I think we should make the empty tomb the emblem of our faith. He said, I don't think you should wear a cross around your neck. If you're going to wear something around your neck, he said, I think you should wear an empty tomb around your neck. And actually, I don't agree with that because for me, the compelling distinctive of our faith is not that God is alive. There are a lot of faiths. The distinctive of our faith is that God died. Where did this idea come from? I'll tell you right now, it did not come from planet Earth. This was not a man-made idea. This came from heaven. What other religion boasts in the death of its leader? There's a movement on today to minimize the cross. There are some that are like, let's not talk about the cross so much. Let's not talk about the blood and the wounds and the suffering and the gore and the horror. And there are some that think with that, but let's just not talk about that so much. But Jesus didn't quite see it that way. He said, and I, if I am lifted up from the earth, will draw all peoples to myself. The cross has a gravity all its own. The cross, if you lift it up, it will draw people to Jesus Christ. You don't have to defend the cross. All you have to do is exalt the cross and the cross will draw people to Jesus. So I'm the kind of guy that goes, I think we should talk about the cross on the job to our neighbors, with our family, with our friends. Let's let the cross become again the centerpiece of our conversations. At the cross, I denied him. I betrayed him. I tried him. I handed him over to Pilate. I beat him. I spat upon him. I put thorns in his brow. I drove nails in his hands. And then I rammed a spear into his side. And here's what he did back. He washed me off. He changed my name. He gave me a brand new robe. He put a ring on my finger. He put sandals on my shoe, on my feet. He pulled me up to the family dinner table. And then he gave me the family fortune. I am in love with the cross of Jesus Christ and the lavish love that he has shown on the cross. I've been, I'm speaking of my voice now, the vocal affliction that has afflicted me for 27 years and the suffering through that journey. When you're suffering, you go to the cross. So suffering has made me a friend of the love Mel Gibson's movie, The Passion of the Christ. Has anybody seen that movie, The Pat Lover? Every Good Friday I'm like, let's watch it again. I love to get up close. But the scripture that I want to come to about that is not up close. It's looking and not is speaking to the cross. And this is actually Moe. And here's what the father says to Satan, Genesis 3.15. He, that is Christ, shall bruise your head thick. And you shall bruise his heel as God the cross with eyes of faith from an eternal perspective.  Jesus was on the cross, nails in his feet, nails in his hand, thorns on his brow, lacerations all over his body. When he was on that cross, my friends, I promise you, it did not feel like a bruising of his heel that felt like a crushing of every molecule in his being because it was. And it's true for you, when you're in the vortex of your trial, you feel like you're being pulled apart molecule by molecule. And you probably are. But there is an eternal perspective to be found on your trial to Jesus today, right now, and ask him, Jesus, talk to us about the cross, like what was it like for you? He might say something, or Siri has been suggesting that the Lord wants to give you the same perspective in your suffering, in your crucifixion, as you endure in this trial. There will come a day when you are gonna look back on the excruciating trial that you're in right now, and you're gonna see it from a totally different perspective. The eyes of faith, you're gonna be going, I took that one in the heel, right? But my adversary has been bloodied in the head.  Satan regretted taking Job on. He regretted taking Jesus on at the cross. May he also regret taking you on. May God do more through your trial than if the trial had never happened. And Jesus went at it, and they were both Satan hit the heel. Jesus made his mark, learned spiritual warfare. Don't go to the adversary. He's not that good. Do the master who will teach you how to head of your adversary. I'm preaching to myself right now, my brother. I'm like, I am in this thing, Lord, to be your pad of one runner. Would you show me how to so endure in this crucifixion that by the time the story is over, I will have laid a blow to the head of my adversary. When I look at the cross of Jesus, and I'm thinking, I've got I've got scenes of Mel Gibson's movie flashing in front of my eyes right now.  It's just a spectacle of blood everywhere. Listen, Satan was more bloodied by the cross than Jesus Christ. Jesus was wounded by the cross. Satan was destroyed by the cross. Is there anyone in the room this morning that has the desire to do damage to the kingdom of darkness? I've got a couple friends in the house. Okay. You may take something in the heel. Victories come at a price. Jesus couldn't destroy Satan without incurring scars. What makes me think I can? If you have no scar, were you even in the battle? Bars, we incur in this warfare. He dignifies them. They become the emblems of our marriage bed, where now we reach our hand into his side and caress the scars that brought us the love of God. And then he reaches his hand into the side of his bride, and he caresses her scars for she now bears in her body the marks of Jesus Christ. And our scars become the tokens of our intimacy with Jesus. If you're going to do damage to the kingdom of darkness, don't be surprised. If you take it in the heel, but Lord, give me eyes of faith to see that what I am enduring right now is but a wounding of my heel in contrast to what I'm going to do to my adversary. Teach me how to lay a blow to the head of my adversary. I'm finished with the message. Lord, I'm asking, give us eyes of faith. Help us to see what you are doing. Help us to see what's in your heart. Lord, I'm asking for my friends that are in a trial right now in this room, some in this room, that Lord, we just were overwhelmed by the natural data. We're overwhelmed by the things that we're feeling and seeing and experiencing and the voices of unbelief are so strong. Lord Jesus, I'm asking, would you open our eyes to what you are doing?  Open our eyes to what you're doing. We ask in Jesus' name. You know what? I'm going to just do one more. I've got five minutes. Let me just do one more thing for five minutes. How do you get eyes of faith? I'm going to do this from the life of David. I think I can do it in five minutes. This is how to get eyes of faith. First Samuel 16 verse 13. I don't know if they've got it on the screen. First Samuel 16, 13. Then Samuel took the horn of oil and anointed David in the midst of his brothers and the spirit of the Lord came upon David from that day forward. This verse explains the life of David. You cannot understand the life of David without this scripture. When Samuel anointed him with oil, the Holy Spirit came on David from that day forward. It was a remaining anointing, and when the anointing of the Holy Spirit came on David and stayed upon him, it transformed his glasses. I want to show you how it changed his glasses. The next chapter is First Samuel 17, and I'm looking at verse 26 if they can help us on the screen. First Samuel 17, 26. I'm going to show you how the abiding anointing of the Spirit changed David's glasses. Then David spoke to the man who stood by him saying, what shall be done for the man who kills this Philistine? And takes away the reproach from Israel. For who is this uncircumcised Philistine? That he should defy the armies of the living God. Go back just one phrase back to uncircumcised Philistine. Who is this uncircumcised Philistine? When David looked at Goliath, he didn't see a champion of darkness. He saw an uncircumcised Philistine. And I'm going, David, what kind of glasses do you have on? And David's going, I'm not quite sure. But ever since Samuel did that to me, something's come on me and I don't see things the way I used to. Now when I look at a champion of darkness, I see an uncircumcised Philistine and I'm going, can I get some of that anointing on my life please? Because I want to have the spirit resting upon my life so that when I look at the challenge, when I look at the mountain, when I look at the obstacle, when I look at the problem, when I look at the culture, I don't see a champion of darkness. I see an uncircumcised Philistine change my glasses. And then the next frame, the last part of the verse, that he should defy the armies of the living God. David looks at the armies of Israel and calls them the armies of the living God. When Saul looked at his armies, he got depressed.   Saul got depressed by his army when the army looked at themselves. They got depressed. When David looks at those armies, he sees the armies of the living God. David, what kind of glasses do you have on? David's going, I'm not quite sure, but ever since Samuel did that to me, something's come on me and I don't quite see things the way I used to now. When I look at the people of God, I see the armies of the living God. When you look at your home group, what do you see? The most dysfunctional random group of people in our whole city. When you look at your worship team, what do you see? You can never find their Bible. All was late to practice, tough to get them in a consistent schedule. When you look at your congregation, what do you see? Show up two weeks out of four, can't hard to get a tithe out of them, won't ever volunteer for anything. Or do you see the armies of the living God?  Would you change my glasses so that when I'm looking at the enemy, I'm not seeing a champion of darkness? I want to see an uncircumcised Philistine and Holy Spirit come upon me in power and change my glasses so that when I look at the people of God, I see the armies of the living God. This is what changes our glasses. This is what gives us eyes of faith. It's the abiding, anointing presence of the Holy Spirit on our lives. Go ahead and just pray one more time with me. You can stand if you want to. Have any father? I'm asking that you would anoint me in your Holy Spirit. I'm asking of change my glasses, open my eyes. Help me to see what others don't see. Help me to see what you're doing. Help me. Lord, when I look at my family, give me eyes of faith to see what you're doing in my family. When I'm looking at my church, oh Lord Jesus, give me eyes to see the armies of the living God. I'm asking, Lord, in my job, in my neighborhood, and in my place of employment, Lord, would you grant to us such a resting grace of the Holy Spirit on our lives that we would see what you're doing? In Jesus' name we pray. Amen. God give you eyes of faith.


For more than 30 years that in Sieb's existence the concerns with accessibility is for people with disabilities and also visually impaired it's in Sieb's ADN. So and this is reflected on the ATMs physical requirements and also on POS physical requirements. For instance the heights of the devices have to be measured into a particular distance in order for people in a wheelchair to be able to access all the devices in a comfortable way. For people with visually impaired disabilities for instance there exist labels with braille inscriptions that makes it easier to identify the devices on the on the ATM. The customer keyboard for instance has a razor dot that identifies key number five which makes it easier to locate the remaining keys. Cancel keys, continue keys and also the correction keys has also raises the information that makes it easier to recognize this type of keys. When a card is inserted for instance the ATM uses sensors to detect the correct position of the card make it easier for people with visual impaired disabilities to recognize the correct position of the card when it is inserted. The razor dot makes particularly important because it is possible pressing this key to switch the ATM into a high contrast mode make it easier for people with visual disabilities to recognize the inscriptions. Also the audio makes a particular important role because it guides people to perform the operations. CPS has major concerns with accessibility so therefore we are always looking for improvements to make the access to these services more easier for everybody.


Give me one athlete that you think needs coffee every day. I'm gonna go Jeff McNeil right now. He looks like he's in a big slump for the minutes. He could use a little pepper to stab. I don't know, someone like Alex Morgan probably. We'll go with Aaron Jones. I'm a Jeff fan, so I think Rodgers needs to have a good season. There we go.


It's okay. Do you hear me? Yes, yes, yes, we can hear you. I was just going to announce your title of this talk. So, Professor Pajevi is going to present us a report on ligand and structure-based studies of natural flavonoids from the plant Silibum Marianum. Thank you. Exactly. Okay. Okay. So, first of all, I'd like to know, do you hear me? You hear me? And do you see my presentation? We see it. It's not on full screen yet. It's just a moment. Yes. Okay. So, good morning or good afternoon to everyone depending on the time zone. First of all, I would like to thank the organizers and especially Professor Anelio Ivanova for giving us the possibility to show you our results as a success story in virtual drug development. As the title of the presentation shows, the study will discuss not only structure-based methods, which are the topic of the school, but also some ligand-based methods. And we hope that it will be interesting for the participants. The authors of the presentations are all members of the QSAR and Molecular Modeling Department in the Institute of Biophysics and Biomedical Engineering of the Bulgarian Academy of Sciences. And let us start. The presentation is structured as a classical study, starting from the rational, formulating some questions, then a description of the data and the methods, then the results will be present by giving answers to the questions set above. This will be done by three case studies. And finally, some conclusions will be drawn to show the outcome of our results. What is the rational of our study? The title of the slide shows this is the importance of natural product for drug development, particularly the biative natural products or a source for medical treatment and preparations from millennium, but they are very much used also in the modern drug discovery. Here you see the pie taken from a very recent publication showing how the new approval in the 40 years, past years, worldwide, that means not only foot and drug administration agency data, are distributed according to their type. And one can easily calculate that about 50% newly drug approval in some way are related to natural products. They are either natural products or their derivatives, or they mimic the function of natural product or contain a natural product pharmacophores. This comes to show how important are natural products for the drug discovery and development. The next thing that motivated us is the fact that the medicinal plants in Bulgaria, that Bulgaria is rich in medicinal plants. We have about 750 pitches, 200 of them are currently in use, and 30 to 40 medicinal and aromatic plants are cultivated. Six of them are most important among those cultivated, and among them is the plant we are interested in. This is Silibum mariano, or known in the folk medicine as the mule pistil. So what is famous this compound with? The seeds and the roots of the compound are used to get the so-called Silimerine extract, which standard application is for treatment of liver diseases. So it roses chronic hepatitis, diseases associated with increased alcohol consumption and exposure to environmental toxins. The new and emergent applications of this extract reveal a number of new effects to mention several, anti-cancer, cardio and neuroprotective treatment of different diseases of lung, pancreas, prostate and kidney. All these effects particularly put several questions when using this Silimerine extract. And what were the questions we put to ourselves? Using in silico methods, can we understand more about admit properties of the Silimerine compounds? We focused on the prediction of gastrointestinal absorption, and this was our case study one. And the second question was using in silico methods, can we understand more about the mechanism faction of the Silimerine compounds? And in this case we focused on the interaction with and prediction of potential protein targets in the human organism of the Silimerine compounds. And this were our case studies two and three. The abbreviation admit, you know from the previous lectures, this stands for absorption, distribution, metabolism, excretion and toxicity associated with the pharmacokinetic stage of the drug action. As any in silico study, this one starts with defining data. Silimerine is a mixture of compounds, but in silico we need a defined structure. And here you see the main active ingredients in Silimerine. Those are seven compounds among them, Silibene A and Silibene B, which are deaesteroisomers. Also, they are dehydroderivatives, dehydro-silibene A and B. These are mostly representatives of the class of flavonoidinans, but we have also some flavonoids like taxifoline. The main methods, they are in silico or computer-aided drug design as stated in the title, represented as a ligand and structure-based methods. Each group has its advantages and disadvantages. And if one can combine both methods when possible, one can really do more effective research. Among the ligand-based methods, we use Thucer modeling, also virtual ligand-based screening estimating similarity between compounds, between ligands. And among the the structure-based methods, we use docking. All these methods will be given, for these methods will be given more details in the further presentation. Let us start with the case study one. We aimed at the prediction of gastrointestinal absorption and focused in particularly on defining or calculating the membrane permeability of the compounds having in mind that the membrane permeability correlates very well with the gastrointestinal absorption. The technique or the method we used is the QSAR model. Most of you know that in general it correlates any activity or property data of the ligands with structural descriptors or molecular descriptors of the compounds. Different kinds of multivariate statistical methods can be used to draw these dependence, but in this case we used the multiple linear regression of two parameters. Here you see a schematic presentation of the idea. If we have two independent variables x1 and x2 using the least square method, we are trying to build a plane that goes, that passes simultaneously most close to all points. These are the projection of the points by x1 and x2 in the space. In our case the dependent variable, the y value, was the effective permeability coefficient measured by PAMPA methodology. This has also been mentioned in the previous lecture. These are parallel artificial membrane permeability assays. Then log g, the distribution coefficient at pH 7 and the topological polar surface area and molecular weight have been used as structural descriptors. The distribution coefficient we calculated by in two ways, by chemaxon marveline and also using the fiscam suit of Perceptor. The topological polar surface area and molecular weight were calculated by the CDK9 nodes. The equation itself in its complete form with all statistical results is shown on the slide. It is based on data of about 250 compounds. You see that we have relatively good statistical parameters, I would say even very good. We calculated not only the fitting coefficient presented here by the adjusted R-square, but also the predictive coefficients by Rikwan-Auth method and by splitting the data set into the training and test set correspondingly shown on the plot in green and red. The plot presents the dependence between the experimental and calculated by the model log P values. You can see that there is a very good correlation between both. We further tested the capability of model to predict GIA assessed on a set of 780 compounds with known gastrointestinal absorption. Where are our 7 compounds from the Cilimarine in this model? It is shown here again the same plot and in black dots you see our compounds. So they have been experimentally tested also to predict their membrane permeability. You see that the compounds fall into the applicability domain of the model and 5 out of 7 go to the half of the model which shows high permeability of this membrane permeability of these compounds. This model gave us a hope that we can also predict the membrane permeability of non-tested flavonulignans and we did this for 31 compounds and for 27 of them we found good permeability and high permeability in the gastrointestinal tract but this hasn't been yet experimentally proven. The next study relates to the interaction of our compounds with the nuclear estrogen receptor alpha. In fact we were interested in toxicity of these compounds due to their broader use and performing silico prediction using the Derek Nexus expert system and the result was that the Cilibin A and Cilibin B are able to modulate the function of the estrogen receptor alpha in mammals without of course giving any differences in the prediction of their effects and thus we decided to perform talking in the binding site of the estrogen receptor alpha. Here you see the ligand binding domain with bound endogenous ligand estradiol and the activation helix 12 which is very important for the function of this receptor in the agonist and antagonist conformation. We used two softwares moe and gold. The docking was semi-flexible solvent was considered semi-flexible docking in this case means rigid receptor and flexible ligand but I have to say that we also allowed the side chains of the amino acids facing the pocket to be also flexible and here I would like to draw your attention on the fact that two positions of the activation helix were taken into account why. I think that in all structure-based studies it is very important to pay attention to what crystal structure, the structure of protein or enzyme we are using because they could be different depending on the functional state they are. This is especially important for the nuclear receptors and also for the trans proteins. The binding site was defined by the ligand. Here I give the data about the PDP complexes used and the scoring functions were London VG in moe and gold score in gold. Both are empirical scoring functions that consider not only contribution to the enthalpy but also to the entropy of the interaction energies. I think that in the previous presentation in the first one was given the formula for the London VG I will not go into the detail more about. We did observe some differences in the interactions of our syllabine A and B in the binding site. This is illustrated here and the differences in the poses suggest some stereo specific interactions. Interestingly, in most cases we recorded hydrogen bond interactions of syllabine B and no specific interactions for syllabine A in most of the poses. Thus we were looking for the experimental confirmation of our results and we were very happy to find in this study that stated about syllabine B and not syllabine A to be responsible for the partial mediated activity in relation to the hydrogen receptor alpha of the polymer ring. In this way we could explain at a molecular level the experimentally observed differences in the activity of both syllabines on this nuclear receptor. The case study three is related to the discovery or to our trial to discover new protein targets of the syllabine compounds. The research strategy is based on the fundamental principle in drug action complementarity between the drug and its binding or receptor binding site in two dimensions shape similarity and shape complementarity and complementarity of the surface properties or surface potentials. The extrapolation of this idea of complementarity between the drug and its binding site could be given to the ligands only meaning that we can look for ligands that are similar in shape and also similar in their surface properties and we use the rock software under the open IPA academic license program to perform such similarity assessment. You see here on the left the shape correspondence and the correspondence in the surface properties is done by the so-called color similarity meaning identification of functional groups, atoms and substructures capable of performing similar intermolecular interactions like scepter, donor, hydrophobic, aromatic, ionic and so on. The similarity has been estimated using the TANIMOTO coefficient. The most simplified form of the TANIMOTO coefficient is shown here. The number of features of one molecule, of the other molecule, the common features between them, but when we try to estimate more complex properties like shape and functional similarities, the form is much more complicated. We have non-binary data. The features are presented at bits sets in the fingerprints and we calculated the TANIMOTO combo coefficient combining shape and color similarity together. Therefore, the coefficient ranges from zero meaning no similarity to two meaning full similarity. The slide shows the workflow of the search. We used all approved drugs from the drug bank to that time they were about 200, 2300 meaning we know everything about these drugs. We know their structures. We know their effects. We don't know their targets. What is very important and we found nine drugs for Cilibin and their dehydral derivatives to have TANIMOTO scores above 0.9 and two of them to be similar to drugs with anti-tumor activity. Then the question was can Cilibins and their derivative interact with the same targets as the similar anti-tumor drugs do? Here we summarize the values of the TANIMOTO combo indices and show what are those two drugs. One of them is Vemurofenyep and it is used for treatment of metastatic melanoma and its target protein is the protein kinase B-RAF and this modigip which is mostly used for treatment of basal cell carcinoma and the target protein is smooth and receptor. But before to proceed further with studying the interactions of our compounds with those two target proteins, we perform additional check using more software by flexible alignment of compounds on the drugs by active confirmations as extracted from their 3D complexes and mapped properties on their molecular, in this case, conical surfaces to see how they correspond to each other and this is seen here. On the left you see the shape alignment between dehydro-Cilibins in green and Vemurofenyep and Bismutigip in brown and on the right the surface properties mapped for Bismutigip and both Cilibins here we have electrostatic and hydrophobic hydrophilic properties. In general, we have better correspondence in shape for Bismutigip and relatively good correspondence in the surface properties, I would say good correspondence even in the surface properties between Bismutigip and Cilibins. We further, as I mentioned, perform docking in the active site of the beerhead kinase you see here the PDB complex we used and the table reports on the docking scores for the best score posts and the first three, the average of the first three of our four compounds and also Vemurofenyep because we redocked our compound into the binding site, our drug into the binding site to get an idea about the docking scores. You see that Cilibins and dehydro-Cilibins have lower docking scores compared to Vemurofenyep but still very good. Here you can see their binding in the active sites of Cilibin A and B and dehydro-Cilibin A and B. I have to say that we especially followed how the interactions compare to the interactions of Vemurofenyep and we found that our Cilibins and dehydro-Cilibins could do interact with the residues. Vemurofenyep interacts with it and in addition we recorded different interactions, especially evident for dehydro-Cilibins in this receptor but also in the other one. Based on that, we concluded that certainly these compounds can interact with B-RAF kinase but it was not enough and we decided to look for the individual validation of our results and we did perform experiments for inhibiting B-RAF kinase in its mutation which is in 80-90% of advanced melanoma patients present, valine to butamic acid in 600 positions and we found in accordance in correspondence with our N-Cilico results that dehydro-Cilibin has the highest inhibitory effect compared to the other compounds. The IC50 of dehydro-Cilibin was about 25 micromole. Further, we did docking similarly in the receptor of Smuton homolog. This is the G-protein coupled receptors, as I said, involved in the head-to-heart signaling pathway, very essential for the cancer diseases development and again we found good scores for our compounds compared to this modigip. We performed a strong validation of our N-Cilico results by two assays and we found very interestingly that dehydro-Cilibin A was active while dehydro-Cilibin B was inactive, both C-Libins A and B showed MUT activity and additionally we performed displacement assay for the best compound and we did find that these compounds bind to the Smuton homolog receptor. The main conclusions drawn from our case studies is that in silico methods are really useful. We could predict the membrane permeability in the gastrointestinal tract. We explained at the molecular level the specificity and effects when interacting with the estrogen receptor alpha and we proposed at the level of in vitro experiments proof that indeed these compounds could interact with two noble targets in the human organism. So we can conclude that in silico methods are very valuable tools when looking for a drug. Here are the publications related to our studies. They all have already been published. We have a lot of support from different programs also from international projects. They are also mentioned here and in the end we formulated three messages to you to take home because we do think that they are important and these are also based on our experiment experience. The first is do not forget essentially all models are wrong but some are useful. This has been said by George Box. So our advice is try to validate experimentally the in silico models and results. Second follow the principle of parsimony or Occam's razor meaning all things being approximately equal one should accept the simplest model and the third advice is no matter what computational method you are using don't get lost in calculations and keep your eye on the goal and in the end I'd like to thank for your attention. Thank you. I see that there's one question in the chat are those 248 old Slavo Nuits are there log p values and toward the log p values taken from literature or measure can you can you please I would like to read the question okay show it yeah well I cannot show it on your screen but you can simply stop sharing my screen so we'll read it again okay are those 248 old Slavo Nuits no no no not okay you mean you mean the model for membrane permeability no no they are different drugs no okay and were the log p values taken from the literature or measured all at once for the model we had measured membrane permeability coefficients otherwise it was not possible to build this plot of the predicted versus observed but for the silimony compounds we did indeed we did experimental measurements using pump assay and this has been shown also by their positions on the plot okay this was a kind of validation of our results okay how did you select those specific descriptors among the vast number of existing descriptors the common sense first of all uh the dependency yes the membrane permeability is a very complex property it depends on many manufacturers most of them are related to the steric and to the lipophilic or hydrophilic properties of the compounds and of course one can do also a lot of calculations using different descriptors performing principal component analysis dividing deriving different kind of transformation of the initial set of variables but we did we did get very good results with these simple models and with these simple descriptors that fully satisfied us and therefore we decided to rely on them okay thank you I thank you for the very interesting talk and now I suggest that we continue with the next presenter yes I would like only to mention that I have to leave now the session and if there will be any questions to us uh I promise to answer later on if you don't mind okay okay okay thank you thank you again