Hey guys, it's MJ the student act tree and in this video I want to talk about my FIFA 17 wishlist and how I think the game should introduce stochastic statistics Now I love this game. I mean I've been playing FIFA since 98. I mean that's that is back in the day and I mean my brother and I we would get the game every year And we love to check out the new features and how they've tweaked the game And so in this video, I just want to talk about two of my Or two items that would be on my wish list for the upcoming game Okay The first one is to have the PSL in the career mode now the PSL is the South African soccer league Please FIFA, please include this. I mean, it would be awesome to have a manager mode on them I mean currently FIFA does have a land of pirates and Kazachis, but as you can see there are so many more teams and I really thought this was gonna, you know be introduced in FIFA 2010, you know when we had the the World Cup and everything but alas that still hasn't happened but now to move on to the main item of my wishlist and This is something that I think is gonna have a big and positive impact on the game and that is stochastic Statistics, okay, let me let me just give a little bit of background and explain what I mean by this Okay in FIFA You have a bunch of players and they each have their own set of stats, you know They tell you how well the player can kick how well he can pass and so forth like that Now these stats are fixed or to use a more actuarial term.  I'm ready to win the league. Okay, and currently I mean the stats look like this These are the deterministic stats And I find them quite boring you've got player a and you've got player b now Let's assume that everything else about these players is exactly the same except for this one key stat Now when it comes to this, it's a very simple choice to just choose player a now what I'm recommending is stochastic stats and This is what it would look like So player a would have let's say sees dribbling skill. It's not fixed It's a stack between 73 and 77 and it only gets determined after the manager has selected his team and started the game and Let's say we've got player B. Well, he's dribbling status also a random number and Now it becomes a little bit of an interesting choice because his has got a larger variance I mean, who would you choose player a or player B? You know, we're introducing a little bit of a risk element, you know Would you would you take a chance and choose player B? You know, he's probably a young unknown player or would you play it safe and choose player a who is probably a more mature and experienced player and then as you play career mode the The player can get more experience and as he gets older He evolves and the variance of these statistics decrease and it becomes more of a certain number to what we have So, you know propose this as an alternative to, you know, just the player stats increasing as they currently have Okay, so what are some of the advantages of using stochastic statistics? Well for one, I mean it would be very easy to code and very easy to implement because already if we look at scout mode and FIFA They had they doing just this. I mean here we go. Here's the scouting screen and What I like about this is the more time you spend scouting a player the narrower that limit becomes and All I'm suggesting is that we move this feature into the core game. You know, it's gonna be so easy to to introduce this Okay, second advantage is we're gonna introduce another talking point I mean when people ask who is the best player in the world, you know, who's the best FIFA player in the game? You know, you can just look at the stats and you can quickly determine if one plays better than another But with the stochastic stats, you know, there's another dimension to consider, you know, who's better player a or player B? Again another another advantage is that I feel it would make the game more realistic You know, we all know that in real life soccer players are nowhere near as consistent as their virtual counterparts in FIFA For example, here are just a few players who play like absolute legends some games and then in others They're just drip, you know, sorry, they're just dreadful. It's terrible to see them But then the following game they back to being brilliant. So there is a lot of inconsistency in real life Another advantage is that stochastic statistics will make the game more fun, you know And I mean FIFA is the game and games are meant to be fun So adding in this random element will bring about, you know, some more excitement And we know this because I mean casinos are successful because they, you know, revolve around this whole randomness and uncertain results And we're just bringing in a little bit of a risk factor into the game And then the final advantage is that it will make the game more educational, you know Already, I mean I play FIFA and I learned so much about the various European towns and you know, you learn a lot of geography And games are an incredible education tool So now imagine if people could start learning the fundamentals of statistics while playing FIFA and getting a sense of randomness And how to calculate that Now, I mean, we could always amp it up, you know We could give each player their own unique distribution And you know with their own unique parameters and you know, we could set that models each player accurately and how they play under various conditions Providing the most realistic experience ever But I do feel maybe Maybe, you know, that's that's something we can introduce later, you know, for now I'll be much happy I will be very happy if we just have a simple uniform distribution for all the players And we just introduce this idea of stochastic statistics And you know, we can bring on those extreme unique distributions Made for a later stage like say for FIFA 18 But yeah, that is that's my wishlist for FIFA 17 Let me know what yours are in the comment section below And yeah, would you like to see this feature in the game? Let me know And yeah, let me know what your ideas are Cheers guys


It is noon on Thursdays folks. Ted Ralston here at downtown Honolulu in the Think Tech Hawaii studios overlooking something in the background. Looks like some structural materials that we left behind from the studio reconstruction. Anyway, we have on our show where the drone leads, where we talk about topics associated with the emerging technology and business of drones. We have with us again a second time flyer on this show, but the first time by Skype we have Gretchen West of Hogan Levels in Silicon Valley with us. Silicon Valley in the world I guess I should say because your company is a global international company. Thank you for having me, good to be back. And we have you by Skype next time we'll have to alternate this in-person Skype, in-person Skype and work it that way. So anyway, Gretchen has a long history in coming up with the policies and the protocols and the methods that we're going to be using collectively to advance this business of drones and unmanned air systems. And Hogan Levels has taken a lead in that as well. Can you tell us an update since last year when you were here about what Hogan's doing and what you're doing in terms of the CDA and activities such as that? Sure. So I'll start with Hogan Levels. We are a global law firm and we have a thriving drone practice where we're working with a variety of companies from small to large on helping them with understanding the drone market and the environment. As we all know part 107 came into effect August of last year and so we've been working with lots of clients to get them waivers for some of the expanded operations. We've been working with clients on the policy side helping them with some lobbying efforts and shaping policy and also working with some smaller companies to help them understand the market potential and find funding for a lot of the startups. From a commercial drone alliance perspective that's an industry-led non-profit association. We formed that really because we felt that commercial end users were underrepresented in the conversation and they really are the most important because they're the customer for all the manufacturers and service providers. And we found that they were skeptical about adopting drone technology primarily due to the regulatory environment but also a lot of these industries these big industries oil and gas, construction, mining, inspection, agriculture and on and on yeah they're fairly risk averse and so because of regulatory environment because of privacy issues because of state and local regulatory issues they're just because of safety and reliability issues they're just concerned a little bit with implementing drones on a widespread basis and so really the mission of the commercial drone alliance is to work to reduce those barriers and help educate them about the benefits of technology so they can adapt drone technology and move this industry forward. That's great. Does that also give the these groups that might be potential end users or intermediate users providing some product for a customer of their own? Does it give them an opportunity to express the fact that they don't understand what's going on and get educated part one and part two come forth with requirements that are really important in their domain and then have the manufacturers hear that and I'm just thinking of the situation out here in Hawaii we have a lot of of course salt air situations so we have a if you look at the drone repair shops out here US repair shops they're basically taking care of salt corrosion on the circuit board so we have that sort of situation we have high winds we have a lot of GPS out areas night areas because of the topography and stuff so would a company out here have a voice to the manufacturers through the cda? Well that's one of the goals that we're trying to accomplish and we've really only been we launched about a year ago and we've been really busy on the the policy side over the last year doing a lot of the things that are happening in the United States on Capitol Hill but the other kind of the other mission we have is this education side and so we've been going out to lots of different events and different industries and just educating about the benefits of drones talking about what part one of seven means talking about what is legal and what is not and what opportunities are there and so from that perspective we're educating the end users but you're absolutely right it also we need to bring the end users into the mix as well and we have several that are part that are members of our organization because they like you said they need to help educate the manufacturers and service providers of what they need it's different from location to location from industry to industry and so you know instead of manufacturer creating a drone that they think could service any industry it's good to know what those end users need and so we are trying to do some of that kind of mash making as well. That's great and I think we're attempting to join your their operation to the cda is the very first academic member in that in that group and of course education and academia kind of go hand in hand that's our role here we at the University of Hawaii we have also all the community colleges and all the islands linked in with the main university so it's like one system so we have a great access to public at the front we have great research functionality in the core and it's a nice setup for both the promotion of the information about drones and also doing experiments and doing scenarios and such with law enforcement and public safety people to pull in what their requirements are and you know you we all deal with what's been provided to us by the manufacturers and we have to be ready for surprises when they when the end users tell us what they really want and I'm sure you've seen some of that in initial interactions with your users against what the manufacturers have thought. Yeah and I think we've seen that for years even before we formed the commercial drone alliance I've been in this industry about 13 years I think and there there was always kind of this gap between what was being developed and what the end user needed whether that was military law enforcement civil or commercial use and I think that gap is shrinking but there's a lot of technology that's still being developed and there that you know we need to bring together the end user community better with people that are making those different types of technologies to make sure that you know we're streamlined across the board. We're going to be taking a first crack at that here in Hawaii in about three weeks we have our our kind of the top of the public safety domain is really the Department of Homeland Security's funded state fusion centers in the various states and through that group we sort of have fingers to all the areas where there's activity in public safety and law enforcement so we'll be starting some of that scenario-based interaction very soon here and again it'll be kind of little steps at a time I think to get to the point where we finally have some kind of a specification that would be useful but I agree with you it's it's been a quite an interesting transition over if you've been 13 years in this you've seen four generations of of rollover happened in this game and just imagine what the rollover is going to happen in the future battery power density reduction in size of some of the critical sensors like adsb and radars and such on board processing to kind of get the man out of the loop and let the drone take care of its own mission so what in your own mind question what do you see as how this technology future is going to evolve in terms of the functionality available to the user well I think you know the end state for anyone that's in this market is really kind of looking at autonomy it's not going to be flying a drone by remote control standing on the ground watching it making sure it's within your visual line of sight the idea because drones are meant to create efficiencies the idea is to reach towards autonomy and so as technologies are being developed I think we're getting closer to that and then you know the regulatory environment needs to catch up to that but you know an example I like to use is you know a farmer right now can use a drone and even they can program it autonomously to fly now but based on the regulations they they have to you know be part of the operation and have their eyes on the drone while it's surveying their field in the future what we want to see happen in this industry is there's no interaction between the farmer and the drone the drone goes out and pre-programmed routes that at different selected times and it and it completes its mission and all the farmer has to do is open up his computer and get the data and get the answers to whatever the questions are and so really it's it's you know it's about autonomy and it's about creating valuable actionable information for the end user and that's part of the requirements structure that we need to be looking at because you know the requirements around you know what a farmer needs versus what a construction company needs from a data perspective could be very different and I think for these end users it's at the end of the day it's not going to be about the drone it's going to be about the information that they collect that's useful and it's in and it's timely and actionable and so I think that's the future of where we're going and in the meantime you know a lot of technology needs to be developed to make these systems safe you mentioned ADSB you know miniaturized ADSB because there are issues with being able to identify drones that are in the airspace now you know technology that can make them safe and reliable to be able to take over if you know what if a propeller fails or something like that so you know those technologies are being developed now but I think it at all because the end goal is is reaching towards autonomy you know it's interesting and last year when you were talking out here addressing the US district court the main themes were going to be the end state functional software that pulls the information together and generates some kind of an expressed set of information to a decision maker that probably hasn't changed the autonomy that is behind that now is interesting to see you're speaking about that sneaking up I think you were speaking of training and countermeasures or control of drones as being the three major legs under that three-legged stool is that still pretty much how you see it today I think it is and I think it's still you know it's still about the data and it's still about the information that the end user wants and needs it's about the safety of the system which can which includes command and control it includes sense and avoid technology it includes you know all of those kinds of things um you know but some newer topics and newer areas of interest are kind of counter drone technology so while everyone's excited about drones and using drones there are others that that you know want to figure out how do we keep rogue drones out of our operations how do we keep people that are you know using their drone to maybe look at uh our facility how do we keep some of those drones out you know a good example is is a is a sports stadium they want to use drones to to film practices they want to use drones personally for their own business at the same time you know during a sporting event they don't want rogue drones flying over a stadium so how do you you know there's a lot of interest in using drones by these end users that there's also interest in keeping out unauthorized or rogue drones so that's counter counter uas counter drone technology is that is a new big kind of trend and I think it's become a very important one that's exactly right in fact I was addressing our department of health here a couple of weeks ago as we do periodically on updating them and they came up with an example that I hadn't thought of but we've already had one case out here where a a rogue situation applied it was a licensed and properly certified operator was using a drone to measure damage on the reef after a recent ship grounding you have to understand what damage you've done to the reef and find some way to fix it so the ship was being moved and then observing it another operator who was perhaps not even certified we don't know was in our following with his drone the first guy to maybe undercut him in terms of the business side of providing information to the shipping company so right away we see even in a simple situation like that they need to know hey my drone's up there I know what I'm doing what's this other guy doing if he knows what I'm doing he's likely copying or attempting to take advantage of what I'm up to so absolutely right even on a one-on-one basis not just a terrorist situation or something like that but plain old business we have to understand what's going on and make sure we those who are properly authorized to perform are are allowed to do that without being interfered with yeah and that kind of comes down to accountability I mean that you know everybody knows that there was a drone registration process where people had to register their drones and it was a fairly easy process to go through and and you know cost about five dollars and that was recently revoked by the courts in the United States and so now nobody has no no hobbyist or recreational user has to register their drones and so there's now a lack of accountability and that's not to say that that community is the one that's that you know they're flying unauthorized or in in rogue ways but but there needs to be some accountability so that commercial operations can can continue and businesses can thrive at the same time as recreational users can still enjoy the kind of the freedom of flight and flying what what were considered model aircraft that that's a really cool word accountability it applies in so many aspects here let's pick that up after our break and talk about it in a bit more detail you're watching think tech Hawaii which dreams live on think tech Hawaii comm uploads to youtube and broadcast on cable oc 16 and a lullo 54 great content for Hawaii from think tech i am an energy attorney clean energy advocate community outreach specialist and on power up Hawaii we come together to talk about how can Hawaii walk towards a clean renewable and just energy future to do that we talk to stakeholders all over the spectrum from clean energy technology folks to community groups to politicians to regulators to the utility so please join us Tuesdays at one o'clock for power up Hawaii you're watching think tech Hawaii 25 talk shows by 25 dedicated hosts every week helping us to explore and understand the issues and events in and affecting our state great content for Hawaii we're back here folks Ted Ralston think tech studios downtown Honolulu our show where the drone leads with our guests standing by in Silicon Valley once again Gretchen West welcome back to our show Gretchen thank you for having me good to be back by Skype absolutely it's good to be back and good to have you here and it's really neat that we have these people all over the country who are willing to spend their time get on Skype and hook up with us because we are kind of isolated from a lot of bus traffic and such out here and keeping in touch with people is really important for us and there's a lot of activity taking place certainly in Silicon Valley where you are what a great place to be and on the other end of the country you got DC in fact you must spend all your time back and forth between DC and and Silicon Valley ideal yeah and so when we're talking before about accountability before the break this issue of accountability and proper use and avoiding misuse and malicious use of drones implies there's some framework of education or information that people can collect and can understand what accountability means in that regard we all know that that's not here yet we have information all over the place like so much of it but it it's hard to really put your finger on what truly matters in fact we're having that very discussion online right now with regard to 107 versus public aircraft ops for civil use what's the better approach even in that fairly controlled discussion there is no one place you can turn to for the salient information that allows you to make a decision so just imagine the guy who uses his drone for wedding photography or fish finding or something like that that where does he turn what what do you see in in your operation when when that question comes up how to get people information about what the limits are yeah and that's a tough one and it just it's education education education and it's really hard to reach the masses you know there's some programs out there like know before you fly the FA has got a lot of information on their website but you know it's hard to require somebody to go to a website and look for information a lot of manufacturers are putting flyers in the packaging of the drone but not all of them are and so you know there's not a good answer and I know this those questions are you know there's discussions are happening all the time just in DC last week we had a conversation around this how do we educate some of the new users because you know for a lot of us that have been in this industry a long time you know that worked in unmanned technologies in the military or for law enforcement or as a recreational modeler had some awareness that these were aircraft and there are rules of the sky now you can go to best buy or order a drone online at amazon.com and and you know you could be a real estate agent or wedding photographer and just don't have the awareness that these are aircraft or that they're flying in the sky and we all know nobody reads every single word that's in an instruction manual so you toss the flyers aside and you don't pay attention so how do we reach those people and it's not necessarily necessarily their fault they're just you know there is not an awareness that there are these are aircraft and there are rules of the sky that they that people need to follow and you know we're talking about hundreds of thousands of people and some of the predictions are getting up into the millions and so you know it's just a matter of constant education and working together across this industry everyone needs to be spreading this message not just a group like the commercial drone alliance or the other nonprofits there really needs to be everybody exactly right that's kind of how we see it out here and again in education which is what we do at the university it's that's something we should be paying attention to and I think we've heard so many times that need and we have it really in in spades at the time of the legislative sessions because our legislators they need information that they can make good decisions based on and our experience last year wasn't good in that regard and so we're taking action now in July to get ready for December and trying to come up with events interactions printed material whatever form makes sense that tries to consolidate things down to a reasonable range of things you have to know about in order to make a educated decision I think at the end of our legislative session last year the last bills that went through the legislative groups that were looking at them simply said we don't have the right background of information in order to judge what's being presented so therefore we'll you know put them in uh Never Never Land so it's interesting that you are sensitive to that as well um and we certainly are here in fact that almost reaches down to the the community organizations and the elementary schools and things like that that where you have first contact with people so one of the thoughts we've got here is projects and programs with the schools that bring in the school kids bring in the emergency response people in town bring in the parents and and take some important but not emergency situation like invasive albiza trees around here and understand how drones could help understand that situation and and prepare for disasters and such in this regard to kind of get the word out in some way but we've even had requests for from not even from our police department here for how do we think of organizing a citizen's core that really wants to use their drones you know they want to do it in the right way they want to support a fire situation or a rescue situation or whatever they realize there's a yellow caution line they can't get across so how do we organize them at some level of training some level of accountability the way you worded it some level of responsibility let them produce information useful to the situation but keep them out of where the area where the area where danger might occur has that sort of thing crossed your bow in terms of a citizen's core of some kind when i think it's i think it's a good idea and it's just a matter of having enough communities that are willing to do something like that and then educating those citizen cores about what the the rules are i mean when you talk about law enforcement you know when the fAA basically said you know they are not going to be able to enforce operations across the country so they wanted to educate law enforcement of what to do what to do if you see someone flying a drone in the park and you know it's just it's pages of documentation on a website and and not every law enforcement officer is going to go and and really absorb that information and so you know there's got to be a better way of doing it and i think demonstrations hands-on you know flying drones understanding what these aircraft can and can't do are really important but how do you do that across this entire country to reach those millions of people that are buying these products and flying them all the time i mean it's really a it's it's a tough challenge and you know it's it shows like these that i think can help educate but we need to have a lot more of this when we joke around because we're a fairly new industry and and not very rich in money but if we had the money it would be great to do a superbowl ad you know in conjunction with lady gaga flying with drones to kind of instead of showing it as entertainment and toys that you know we need a superbowl ad we need something comparable to that that reaches a tremendous amount of people and it's just we're just not there yet agree on that you know there's there's another side to this accountability issue that we that we're just talking about here the education component leading to accountability there's also on the manufacturing side something very interesting to me personally and that's what you might call the safety and response and reliability and uh reliable life cycle cost aspects of a drone if you're in the fire department and you will buy a new set of motorola radios you pretty much know what their reliability is going to be and how long they're going to last and what the warranty service is on them if you go buy a drone i bet none of that is evident to you you don't know how long it's going to last you don't know how many you have to buy because you may lose one if you start depending on it and then you have to have backup so there's this whole concept of the life cycle utility of this technology that we i think need to have the users stand up and and demand and push that over to the manufacturing side i mean i was just reading something on google last night about some guy who from one of the really highly placed educated business journals that was going to examine and evaluate and report back on his new two thousand dollar drone he brought out here to Hawaii and he said but i can't because it's stuck up in the mountains i can't get it so anyway uh the these are single string dependence systems we have in general and if the gps goes down or many other kinds of malfunctions that can occur we lose them so if you're a public safety guy you're depending on this thing to return useful information in a dynamic situation it's got to be there has the industry and you've seen industry more than we do i would love to figure out how to talk to the industry i don't know how to but if you have they addressed that kind of an issue of a life cycle reliability as part of the accountability equation yeah i mean i think the closest thing there's a program that was kind of founded i guess by nasa it was invented by nasa and it's called new star which stands i don't even remember what it stands for but it's basically an underwriters lab for drones there's there's a facility being stood up right now in new york upstate new york where basically the drones are going to be tested based on their manufacturing specifications so they'll go through wind tunnels their their technology of return to home and sense and avoid and and all of these different technologies and the the vehicle platform itself will be will be tested the endurance will be tested so if a if a manufacturer's specs say that it can fly 15 minutes in whatever knots of wind it'll be tested and so then on the back end there should be more reliability to the consumers that or the end users that are buying these drones have some sort of comfort that these drones have been tested and they've gone through some sort of standards and and so this is it's new um cylinder development but i think it it will hopefully address a lot of that that's great i'd like to know more about that so you get like an energy star compliant stamp on your drone when you go buy it you get some confidence it's going to be there but you mentioned the word standards a lot of important we're right alongside accountability standards are something that an sci is starting to push on astm is uh the uh not the cda is one thing but the other group is the uh the one out of the department of commerce under rtca that's looking at standards and radio communication and software and such from your perspective how do you see all those standards activities moving along coming together sharing information resulting in one pile of standards not four different piles of standards yeah and i think that's another tough tough thing that we're seeing right now i think antsy public published a list of maybe 20 or 30 different groups that are looking at standards for our community and so you know they there needs to be kind of an ombudsman that pulls all of this together because i i know that industry is starting to form its own collective groups to look at standards for different types of use cases and so you've got the formal standards groups then you've got industry that's trying to work together to create kind of kind of some community-based standards and so how does this all mix together how does it feed through the drone advisory committee if it does it all and i just i think there's so much there everything's kind of scattered right now and so how do we bring that together and that's something that commercial drone alliance is considered is to be kind of a glue that maybe can bring together all these discussions but it's it's a it's a big task to do so we got a lot of big tasks here it's a it's a a big business lots of little fragmentation going on and you've been in it for 13 years and seeing incredible change over those 13 and what do you think the next 13 is going to hold i think we're going to see you know even more advanced since we're going to get to autonomy we're going to get to be able to fly beyond visual line of sight we're going to see package delivery we're also going to see a lot of counter drone technology we're going to see you know more requirements on the drone for remote identification you know we're going to see security concerns being addressed in a more meaningful way i think we're going to see flying taxis so we're not just going to see these small drones we're going to see larger drones that are carrying people now we're going to see an air traffic management system that can manage all of this i think you know we're just still really at the beginning of this technology which has been around for 40 or 50 years and you know it's just we're just going to see some rapid advances and it's an exciting time i mean we're just we're still really at the front end of a lot of the development of the technology i agree it's an exciting time i've only been in this for maybe five years not anywhere in the length you've been in it but every day bring something new and some new elevation some new idea that somebody's gotten and david plays publishes it and robin alexander publishes it we all get to know about it and then we get to have you on tv and get them on tv and and talk about their ideas in a ways that can be passed around so once again gretchen thanks very much for coming on the show today and last year as you did next year you have to be in person here and best of luck to the cda of course we're attempting to be part of that at u-h and uh we love your projections for the next 13 years and we'll have to hold you accountable once a year for those next 13 to make sure they all come true i hope that will stay here having me and aloha okay aloha thanks for being on the show


The Liz Lerman Dance Exchange, which is a modern dance company located near Washington DC, created this amazing dance performance related to the human genome. You take a form like contemporary dance, which is a little hard to understand. You take genetics, a little hard to understand. You say, let's put them together, and everyone will understand. It's like, how's that going to work? But actually, it does. After seeing Ferocious Beauty Genome, members of the Dance Exchange and the NHGRI got together and created this idea for a workshop that would explore genomic science through dance, specifically for high school students. So the NIH team composed of educators and researchers, along with the Liz Lerman dancers and choreographers, decided to pull together and create choreography or activities around subject matter that the students were already familiar with. The idea was to make it unique and something different from the way they were normally taught in the classes. The main goal is to teach the science through the dance and through the arts and really how that connection can be made. About a month later, 70 students arrive at the Atlas Theater in Washington DC. The students will have to choreograph one of four topics in the groups they get split into, one of which is mitosis. We've talked about mitosis as the dance of the chromosomes because, again, it's just like a production, right? We gave the students an overview of mitosis, taking them through the various phases, and then we asked them to choreograph movement that depicted each of those phases. At the center, I like the coil to shape. I like that idea of the mirroring of the drag. Can't go wrong with the coil. I started to just implant places about speed. We gave the students few parameters to work within. The idea was for them to create something that was totally their own. Hopefully the students will create something that their peers will enjoy, but that also their peers will gain a new understanding of the science, and in this case, it was mitosis. Break and down. You guys stay. Let's start. Break. Break. No, no, no. You break. You guys will be dragged. Okay, I'm wrong. You break and drag. The students have about two hours to learn the major concepts of mitosis, explore those concepts through dance and movement, and then create brand new choreography that essentially will teach other students those major concepts in mitosis. After they're done creating their choreography, they'll have the opportunity to perform it for their friends and other students who are part of the workshop. There we go. Now we have two identical. Our students are dancing mitosis, if you can believe that. They're dancing what happens when mitosis happens right, and when it goes awry. I die because I'm the protein. I'm the protein that dies in the cell, and then afterwards they become corrupted, and they become cancer cells, and they die eventually as well. Excellent work. In 15 minutes, you have two very different representations of mitosis. You worked as a team, you know, it's not exactly easy to collaborate with seven other people to make something especially in such a short amount of time. So awesome. Now it's performance time. You can tell the students are excited and probably a little bit nervous to show what they've done, what they've created for the other students and for their friends. I'm really excited for the students. They've put together two very creative and unique performances that depict mitosis. I wanted them to see biology in terms of how it relates to them, not just what they're reading from the textbook, and how other people actually are interested in science. It's not just the geeks and the nerds who like science. You have dancers now who are interested in science. One of the comments that one of my students said was that she said it was much freer than being in the classroom. You got to actually explore something, an explanation and a different means of explaining a concept that they knew already about and just learn from a book or from a microscope. I want them to have a new way to learn science and something they can have fun with and maybe learn something new about science that they didn't know before or take something they learned in the classroom and expand on it. I think what surprised me was initially the students were very tentative about doing this but by the end of it they really got into it. I mean they really were visualizing what mitosis looked like through dance and I'm so impressed with them because all the inhibitions were gone.


One of the stories that I love in the Bible is the story of the three Hebrew boys when they stood up against the king Who made a big deal about worshiping an idol and he said if you don't worship this idol I will throw you into the furnace of fire And the three Hebrew boys they dare they dare to defy the king by not worshiping his idol And of course his pride was injured injured so deeply that he caused the furnace that they were supposed to be thrown into to be kindled and to be Raised in the temperature by seven times now. I don't know logically and I had no idea how they can do that in those days It's one thing when you take fire and make it twice hotter Seven times hotter is really really hot It was so hot that the strongest man of Babylon threw the Hebrew boys into the fire and the strongest man Died trying to throw the guys into the fire. That's how hot it was And so you can imagine these guys are going into the fire the guys who threw them already died and as they are there The Bible says God comes in their midst with them Their faith didn't protect them from the fire It didn't remove the fire and It didn't remove God The idea that many times we have about faith is that if I have great faith, I will not have fire in my life And if I have fire in my life that means I don't have great faith and that is not true An amazing part is three boys are there and the King notices he's watching at the furnace and he's seeing them walking in the fire The fire is still there, but they're not dead. See real faith is not when you can avoid the furnace It's when you don't die in the furnace Other people even come close and they die in it They become so bruised broken and beaten by it and you are in it walking and not that it's comfortable Not that it's your vacation, but you are not dead by it You're not defeated by it and you are not defined by it. That is real faith And so we see these three Hebrew boys They walk around in this thing and the Bible says the king is looking and he says I Didn't we throw the three guys.    He's the living water fire living water water kills the fire Simple. He's the light. I got some darkness should dark light to move the darkness But that's your little theological logic doesn't always work in life. How many figured that out? Sometimes you have Jesus and you still have fire. What does he remove if he's still with me and he doesn't remove the fire? Before Jesus removes fire He usually first removes the fear removes the fear For many people it is not the fire that kills them It's the fear When you what is fear of fear of what? Then what you're in right now will never change Then what you're in right now will never stop and what you're in right now you will never Overcome that fear many times paralyzes people. No wonder David says in Psalm 23 He says the following the dough I walked through the valley of the shadow of death. I will fear No evil for you are with me mark this Until you don't fear in your valley.


date eight years ago I Stood here with my family in this same dress as a matter of fact when my husband was nominated for the first time and four years ago I stood up here and thanked you for all that you've done for me Not knowing that I was going to have a chance to do it again But you've given us such a wonderful life a life that I really never dreamed possible and it's the most extraordinary feeling to represent a nation and its people And I can never thank you enough for all the experiences and memories that you've made possible The last eight years have been the most fulfilling ones of my life Tom mentioned the drug letters that I have received in the program this meant so much to me but you really Gave me that chance and you really Gave me the chance to be more than I thought I could be and brought something out in me that I didn't know was there and You helped me and I thank you a great deal for that always been there for us It's true.  I'll never forget you So Good night and God bless


They had one that was on a check flight, so they actually took it out here and they lifted it up and when the other ones came on it came off. It looked like the way we handled it, it looked like it was on its own. But it was in the air. I'm Captain Jorge Snooki-Alvarez, I'm the Assistant Maintenance Officer for HMH462 Heavy Hollars. About 48 hours ago we received the order to compile our echelon 1 for the alert contingency MACTAF. As you can see we got the supplies needed to deploy to make that requirement for mission. That mission is to provide the MACTAF commander, assault support transport of combat troops, heavy equipment and supplies, day or night under all weather conditions during expeditionary joint and combined operations. My name is Corporal Azbit, I work at HMH169, I'm a 6174 crew chief Huey. So 1-6-9's role during ATM operations is to be able to provide multiple different missions as in CASVAC, humanitarian aid and anything that we can do with our helicopter to be able to assist whoever is in need. So during this process we ensured that we had our multiple aircraft ready to go for this mission. This morning we all met, did a roll call and went to get our gear issued. We received sea burn gear, we went and got weapons issued from the armory and prepared to go anywhere that we needed to go on that moment's notice. So doing this drill demonstrates that what we need to do on that moment's notice is actually real and it's important. So it gives us the capability to be able to rehearse that so that when the day comes to actually have to do it at the time we'll be able to do it on that moment's notice.


President Mohamed Abu-Hari has said that despite the disruptions in global economy and internal troubles, the Nigerian economy has continued to be resilient and maintains an upward trajectory. Speaking at Presidential Villa Abu-Jadrin inauguration of the Presidential Committee on the National Economy, President Abu-Hari said the COVID-19 pandemic, the warring Ukraine, and the loss of substantial volumes of oil have had negative impacts on the Nigerian economy. But however, here showed Nigerians that despite these hiccups necessitating borrowings from financial sources, the current administration remains committed to the welfare of the citizens, especially the implementation of the social investment programs. Just as the world was beginning to recover from the coronavirus, the conflict in the Black Sea region between Ukraine and Russia worsened the challenges already being faced and created additional problems to which policy makers are having to respond. Our economy continues to grow despite adverse effects of rising interest rates, a stronger United State dollar, and higher inflation across the world. It is however important to know that some of the issues we must address are peculiar to us. For example, the decline in our production of crude oil. Hello, hope you enjoyed the news. Please do subscribe to our YouTube channel and don't forget to hit the notification button so you get notified about fresh news updates.


I'm Keri Konoski and welcome to this month's edition of kidney cancer news. I have no conflicts of interest to disclose. The outline of my presentation is as follows. I will start with a short introduction on synitinib for the treatment of advanced renal cell cancer. Thereafter, my presentation will be focused on the potential role of genetic polymorphisms in personalized medicine. In particular, I will discuss the role of genetic polymorphisms for the prediction of efficacy and toxicity of synitinib treatment in patients with metastatic renal cell cancer. In 2006, synitinib has been approved for the treatment of advanced renal cell cancer and currently synitinib is the most widely prescribed drug for this disease. However, about one third of patients experience progressive disease and do not benefit from synitinib treatments. In addition, synitinib treatment is associated with a wide range of toxicities. Therefore, pretreatment markers are needed to identify MRCC patients who will benefit from synitinib treatment and who will not. Pharmacogenetics may be useful for this purpose. As pharmacogenetics investigates, the relationship between genetic polymorphisms and the response to treatment as well as drug-related toxicities. In particular, single nucleotide polymorphisms may be useful for personalized treatment planning in patients with MRCC. As Dr. Heng already pointed out, a single nucleotide polymorphism is a variation within a DNA sequence. The DNA code is specified before nucleotide letters, A, T, C, and G. A SNP variation occurs when a single nucleotide is replaced by one of the other three nucleotide letters. In this example, the DNA molecule below differs from the DNA molecule above at the single base pair location. This represents a CT polymorphism. Although single nucleotide polymorphisms do not result in physical changes nor affect the production of proteins, it is believed that other single nucleotide polymorphisms may predispose to disease or may even influence response to drugs. In case of synitinib, the efficacy and toxicity of synitinib is determined by pharmacokinetic factors. After oral administration, synitinib is absorbed in a gastrointestinal tract for which the efflux transporters, ABCB1 and ABCG2, may be important. In addition, SIP3A4 is an important enzyme for the biotransformation of synitinib. SIP3A4 is expressed in a liver, and its expression is regulated by the nuclear receptors NR1I2 and NR1I3. In addition, other SIP enzymes, SIP3A5, SIP1A1, and SIP1A2, may be involved in the metabolism of synitinib. Besides pharmacokinetic factors, pharmacodynamic factors regulate the efficacy and toxicity of synitinib. Important factors of synitinib include the vascular and nautilio growth factor receptors, the platid-derived growth factor receptors, and FLID3. In case of RCC, inhibition of VGFR by synitinib is an important mechanism as it results in the inhibition of mitosis. Considering these pharmacokinetic and pharmacodynamic factors, we decided to investigate single nucleotide polymorphisms in these factors. The selected single nucleotide polymorphisms are depicted in green. Of note, we could not investigate genetic polymorphisms in SIP3A4, as no functional polymorphisms have been identified yet. The objectives of our studies were to identify genetic polymorphisms that are associated with a prolonged progression-free and or overall survival in synitinib-treated MRCC patients. In addition, we investigated the correlation between genetic polymorphisms and synitinib-induced toxicities, as well as hypertension that develops during synitinib treatments. For these studies, patients treated with synitinib were recruited from six Dutch medical centers. For the efficacy analysis, 136 synitinib-treated patients with clear cell histology were included. For the toxicity analysis, 219 synitinib-treated patients with various malignancies were selected. For the hypertension analysis, the cohort was extended to 291 synitinib-treated patients with various malignancies. Of all patients, germline DNA was isolated from blood samples, and a total of 37 polymorphisms in 50 candidate genes were analyzed. For the efficacy analysis, progression-free and overall survival were determined, and the toxicity was graded according to the CTC guidelines, version 3. Starting with the efficacy analysis, we performed multivariate analysis for progression-free survival in 136 patients with clear cell histology. Among the clinical characteristics, the MSKCC risk factors, the number of metastatic sites in age, were associated with progression-free survival. Among the genetic polymorphisms, polymorphisms in CYB3A5, the NR1I3 haplotype and the ABCB1 haplotype were associated with an improved progression-free survival. We also performed multivariate analysis for overall survival. And among the clinical characteristics, the MSKCC risk factors were the only clinical characteristics that were associated with overall survival. In addition, the presence of an A allele in the feature of R2 gene was associated with an improved overall survival in these patients. Going back to the results for progression-free survival, we were able to define a faithful genetic profile. Patients were carriers of the faithful genetic profile if they had at least an A allele in the CYB3A5 gene or a missing CAT copy in the NR1I3 haplotype or a TCG copy in the ABCB1 haplotype. Nineteen-five out of 136 patients were carriers of the faithful genetic profile. When carriers were compared to non-carriers, carriers appeared to have an improved progression-free and overall survival. This was 13 versus seven months for progression-free survival and 19 versus 12 months for overall survival. In multivariate analysis, the faithful genetic profile was still associated with an improved progression-free survival and showed a trend for overall survival. To the left, the survival curves for progression-free survival are presented, and to the right, the curves for overall survival. The genetic polymorphisms that were investigated for relation with efficacy were also investigated for relation with synethanib-induced toxicity. Previously, Van Urpet all have shown that genetic polymorphisms are associated with synethanib-induced toxicity in 219 patients with various malignancies. In that study, genetic polymorphisms in CYB1A1, FLIT3 and the NR1I3 haplotype were associated with development of leukopenia. In addition, genetic polymorphisms in CYB1A1 were associated with development of mucosal inflammation, and the presence of a TTT copy in the ABCB1 haplotype was associated with an increased risk of hand-food syndrome. Finally, genetic polymorphisms in VGFR2 and the ABCG2 haplotype were associated with development of any toxicity higher than grade 2. Among synethanib-induced toxicities, hypertension is a common reported side effect. However, the mechanism by which synethanib-induced hypertension has not been clarified yet. These studies have shown that VGFR2 is an important factor in the regulation of the vesculotone. Activation of VGFR2 by PI3 kinase in its downstream act stimulates endothelium-derived nitric oxide synthase, leading to the production of the potent vasodilator nitric oxide. Nitric oxide itself is able to inhibit the production and activity of endothelium-1, which is a vasoconstrictor. But when the bioavailability of nitric oxide decreases, the activity and production of endothelium-1 increases, leading to vasoconstriction. It can be hypothesized that inhibition of VGFR2 by synethanib results in imbalance between vasodilation and vasoconstriction, leading to the development of hypertension. Considering these factors in the regulation of the vesculotone, we investigated polymorphisms in VGFR2, enos, and endothelium-1. In that study, 291 patients treated with Sunicnib and with various malignancies were included, and we found that single nucleotide polymorphisms in VGFR3 were associated with the development of grade III hypertension during the first treatment cycle. In conclusion, our studies show that pharmacokinetic, but not pharmacodynamic, polymorphisms are independent predictor factors of progression-free survival in Sunicnib-treated MRCC patients. In addition, polymorphisms in genes encoding from metabolizing enzymes, efflux transporters and drug targets are associated with Sunicnib-related toxicities. And genetic polymorphisms in VGFR3 independently predict development of grade III hypertension during the first treatment cycle of Sunicnib. These results show that genetic polymorphisms are promising for the prediction of the efficacy and toxicity of Sunicnib in patients with MRCC. And these studies indicate that prospective studies are needed to validate the clinical value of genetic polymorphisms for individualized treatment planning in patients with metastatic renal cell cancer. And with this, I would like to end, and I would like to thank all patients and investigators who participated in these studies. Currently 25, I live in New York with my family, and I'm about an hour and 15 minutes north of New York City and Westchester County. I'm a fellow student, I actually graduated in about two weeks. I'm an applied psychology major, and it will be for my undergraduate degree, but I'm looking forward to finishing very much. At the time, I was 23 years old, it was the fall of 2009, early October, I was working with a development and disabled girl respite hours at her home, soliciting the appropriate social behaviors, so to speak, and I would take her out into the community and do things with her. And she was very heavy, and she had a lot of action on one side of her body, so I'd have to pick her up a lot. And in doing so, I got a bulge disc in my spine. I went to an orthopedist, because I just felt shooting pains in my back and in my legs, and it was the same old thing that I always feel with most people when they go to the doctor, they go, okay, well, here's some anti-inflammatories, and here's some painkillers, seen me in two weeks if it still hurts. So that's what I did, and I saw him back in two weeks, his name was Dr. Daniel Southern in Richfield, Connecticut, and he said, okay, well, you know, if the pain is still here, let's get an MRI, and I said, okay, good, that's great, because I don't, you know, this pain is not going away, and it was awful. So then I went to get the MRI, and then it took about a couple of days to get that back, and I came to meet with him in his office with my mother at the time. And he said, yeah, you know, the MRI got confirmed, you have a bulge disc in your lower spine, and I said, okay, great, and then we talked about how we would fix that with either oral pregnant zone or an epidural into the lower spine into the disc. And that went well, and that was taken care of, and we had the whole discussion about how I was going to recuperate from that, and what I needed to do for my back, and maybe a little more proactive about how I'm listing people and things along those lines.  When I left that office that day, and it sounds silly to say it, but I just think that intuition told me that it's not going to be a good outcome, and then maybe I'm sure you can relate to that. And from there, I went to go see a urologist in Danbury, Connecticut named Dr. Broder, who sent me to get a CT scan and an ultrasound, and that whole process with Dr. Broder took about a month and a half or so for the end of October through most of November, and when he had concluded of doing the CT scans and the ultrasounds, he said, you know, he's like, it just, he's like, it can't really be cancer, you're 23 years old, you're a healthy female, you have no predisposition to it, no one in your family has ever had kidney cancer, he's like, I'm really leaning towards an abscessed cyst. He said that his urologist in his department had gotten together and assessed my case and said that that's what it was, and he sounded very convincing. In that day, specifically, my mother and my father were there with me, and the way he had said it just wasn't enough for me, he kind of looked at me and just said, I'm 98.9% positive it's not cancer, and I, as sippy as it sounds, came back and said, but you can't tell me that it's not, right? And he said, well, no. And I said, okay, well, then I would really like a referral. So from there, I went to go see Dr. John Colberg at Yale Urology in New Haven, Connecticut, and I had met with him several times. And at first, I think that he kind of also dismissed my case saying, you know, it doesn't really look like it, it was grayish and black, there was really no definitive answer. And then one day I was sitting in his office again, it was the fourth or fifth time that I had seen him because I was so adamant about wanting an answer because it had taken so long so far with no responses to what was really going on. And he started listing symptoms and asking me if I could recall having any of them. And the one that struck me the most when he was reading through different various symptoms was that I remembered having terrible night sweats that summer, the summer of 2009, all the way through the fall and thinking I'm like, you know, I always would sweat through my sheets.  But when I told that to Dr. Colberg, everything changed that day. He wanted to do a biopsy that week. So I went and had a biopsy at Yale. And about five days later, he said, just call the office, we'll have the results, and we're absolutely going to know what's going on at this point. And I said, okay, great. You know, finally, I'd get some answers. However, I would call every day. I still remember his secretary's name, Lucille, because I would call her every day after the five-day period of when those results should have been in. And every day she'd said, oh, Jessica, they're still testing them. They're still testing them.  And I said, okay, but I would be persistent and call her every day. I think at one point she was terribly annoyed with me because I would call her multiple times a day because then it was about three weeks later in that grace period of, you know, the five days. And on one day I called her. This was like mid-December, about December 18th or so of 2009. And she said, oh, Jessica, your slides were sent out for confirmation to Sloan Memorial in New York City. And I said, oh, okay, great. And as I knew as this was going to sound, I didn't even know about Sloan Memorial Hospital. So when I looked it up on the Internet, it said Sloan Memorial, you know, Cancer Hospital. I said, oh, well then that's really what it must be, which, you know, I had always felt that that's where it was going to be, but no one, I think, wanted to say that to me. No one wanted to put themselves out there to say that a 23-year-old perfectly healthy female with no previous medical history at all has cancer. And on December 21st, 2009, Dr. Colbert called me. I was actually walking into a mass statistics final at my university. And he told me that it was confirmed that I had papillary renal cell carcinoma type 1. You know, people ask me all the time, like, how the story of it happening, how they even found it, because the odds of it, and Dr. Colbert had told me the odds of them ever having found it wouldn't have been until it was way later hadn't I gotten hurt. And it was also interesting for multiple other reasons that my tumor was inside, embedded, right into my urinary tract or urinary ducts in the kidney itself. It was inside and not on the outside of the kidney. So that my understanding that is why they had suggested that they would have had an abscessed cyst and so forth, or a benign tumor of some sort. I can never pronounce the name of the one they always talked about. Angela Pyle and no mothers. I don't really know how to say it, but I know that they always they kept saying that it was probably that. But it all changed when I had gone over that I had night sweats with him. I had surgery December 30 2009. I was in the hospital for seven days. It was there for a week. We had decided it was my decision. Well, sort of my decision. I knew that I was going to have to have it removed, but it was either a decision between a full nephrectomy or a partial nephrectomy. You know, removing the kidney. And to my knowledge as well, at the time, there was no doctor who was willing to do this laparoscopically because of the where my tumor was in my kidney. And it quite honestly was mortifying and probably one of the most terrifying experiences of my life to date. And I think that most people have been through quite a lot, whether it's medical or anything in your life. And this was the most terrifying experience. I also had an extreme phobia of needles. So even thinking about someone cutting me open and removing a part of my body was just absolutely horrifying. So I went in for surgery December 30. And I was there for five days. I woke up out of surgery. And he had felt like someone had taken a saw blade to the side of my body like they were cutting down a tree. It was an awful excruciating pain. I've never felt anything like that in my life. But I think that it makes me a stronger person now, looking back. But I didn't get up the first day. I wouldn't get out of the bed. And partially also because I found out that I was allergic to morphine. And I couldn't breathe when I woke up right away. I was on oxygen for a few days. And I had hives and I was very swollen. And then I was put on, I'm going to forget the name of pain medication, but I was on that for the entirety of my stay there. And I didn't get out of bed till about day three. I had sat up on the second day, but it was just I can't I just can't even describe the pain. It's unbelievable. And then after my seven days, I also spent a year leave in the hospital. That year, I went home. My parents took me home and I didn't leave my house for about six weeks, according to what my doctor had wanted me to do. He said that I would not feel comfortable in a car. And I had I was such cabin fever because all I wanted to do is leave the house.  You can hardly get out of bed. It took me about three weeks. I stayed in the guest room in my family's house because I couldn't walk up a flight of stairs because it was just too painful. But after about six weeks, I had gone back to let him look at my scar and how it was healing. And it, it looks fine. It looks great.  I'm perfectly healthy now. It's just, sorry. It's such a difficult memory to talk about, but a very positive one too, because it only makes anyone who's dealt with it or is dealing with that much stronger. I think that it has made me an incredibly strong individual. I was never I wasn't a weak person prior. I always found myself to be a strong person, an outgoing person, a leader in some ways. And after this happened, I think for the first year afterwards, I was, I was distraught. I felt like, you know, why me? And it was a very self-pitying attitude. And I was never that person. And my mom would talk to me, she was the biggest and my father, my mother and my father and my brother and sister have been the most supporting people. Without them, I don't know where I would be, especially my mother and father, they would support me like no other. And I think that it was through what they would tell me. And you know, that nothing, if I could beat this, that I could do anything.  And if you can do this, you'll be a stronger person for this. Having this experience, having gone through this experience, I am such a strong person now. I don't let things get to me like they used to. And if they do, I have to remind myself where I've been and where I am. And I think that it really has impacted my life in a weird way for the better, to be a better person. If I could say this bluntly, I would say to keep your head up and to realize that today sucks, tomorrow might be worse, the following few months might be even worse than the day that you had today. But if you can get through this, and if you can keep your head up and realize that there are people who love you and support you, and that you're not alone, and that there are so many other people out there who are dealing with what you're dealing with, that you can, you can push through it. You can realize that there's more to life than letting something like this trying to ruin it. And that's what I've gotten personally from my own experience. And that's the best advice I could give anyone is that kidney cancer sucks. The experience is not wonderful. But if you can get through it, you are going to be a very strong person. And you're going to love yourself even more. Join us again next month for another edition of kidney cancer news. I'm Kari Kanoski, wishing you good health.


Hey guys, my name is Frederick Chen and last week was my one-year anniversary of being vegan, so I thought I should do something vegan related for you guys.  But with some research, I found products that work for me and are vegan and cruelty free. And let me tell you, I have a sinful amount of products. I think I have about 1, 2, 3, 14, 16, 17, 18, 3, 24, 25. 25 products. I mean, it's kind of sad, right? Now let's just notoriously known for being passionate about animal testing and they are constantly fighting it. The first product is the solid shampoo bar jumping Juniper. Now if you don't know what a solid shampoo bar is, it's basically three bottles of regular shampoo compressed into this little thing. It just smells like Juniper. I don't even know what Juniper is, but it smells good. The next product is the comforter shower cream. Now the bubble bar form of this is amazing, but I found that this is a bit too liquidy and it runs out too fast. Plus, does this look good to you? I don't think it does. I don't know what's at the bottom of this. I've tried cleaning it out, but it does not work. I mean, it smells amazing like vanilla and berries, so I'm going to buy it. Next is magnificent soap.  Literally, there's chunks of mangoes inside of this. I mean, it's soap. What do you want me to say about it? Now this thing is less than the size of my hand, but I've been using this for weeks and I haven't even made a dent in it.  That's what this smells like. And this is mostly used for morning showers to winky you up, but I don't take morning showers. Now this next product looks disgusting, but trust me, it isn't. It is the Pearl Massage Bar. When you first buy it, it comes with these little tapioca pearls around it. I don't know. Lush is weird. And I found that when you rub it on your body, it feels like your cat is scratching you, so I just popped them out. Basically, it's just solid moisturizer. Oh my God, I got through Lush. Now no one has ever talked about this company, but it's Yes2. And Yes2 basically uses one ingredient like cucumbers, tomatoes, or coconuts, and they're going to change that into some product. And this one's made of cucumbers and is their daily moisturizer. And let me tell you, this is a staple for me. I've had it ever since I became vegan and I haven't even gone through it, but their packaging is very cute. This one is Yes2's Grapefruit Moisturizer with SPF15. Now if you don't know what grapefruits do to your skin, it's supposed to just brighten everything. Now this one I stole from my sister, and it's just an eye gel that you have to put at night after your eyes are burning from looking at a computer. And it smells like cucumbers. By the way, don't try eating this because I've tried it before and it does not taste like it. This is one of their new products, but it's a spray on lotion. This one's made from coconuts and it's supposed to hydrate and restore. And I like Yes2 because they put a percentage of how natural it is. Like this one is 97% and it's a spray. This is going to take so long to get through the rest. This is their detoxifying charcoal mud mask. And it seems weird because it's made from tomatoes. But basically, if you have acne, the tomatoes are supposed to clear it up and it works. And what I hate about this packaging is that you have to use all the mite that God gave you to squeeze this out of the bottle. Oh my god. So Alba Botanica is known for being 100% vegetarian, no artificial coloring, or any of that stuff. And all the bottles are made from 100% recycled material. Let's look at the packaging. So this is their Hawaiian shampoo and it's made from coconut milk. And for some reason it's clear, but when you put it in your hair, it's basically a conditioner and a shampoo. And it smells like pina colada. This next product is their Hawaiian body scrub. And this smells basically like pink lemonade, except it's not pink, so it's just lemonade.  Like let me read these off. Citrus peel oil, sunflower seed oil, jojoba seed oil, avocado oil, lime oil, sweet almond oil. There's a lot of oil in this. This one's from Anthropology and it's their super collagen mask. And oh it's got wheat. But this smells really herbal and this just makes your skin look healthy. This next product is by Queen Haleen and it is their mint julep mask. It's full of QUE. And I mean this took out literally all of the oil on my skin. So I'd use this around maybe once every two weeks. I don't even know what this company is, but it's called Freeman. And it's their charcoal and black sugar polishing mask. Why am I dropping everything? And for some reason this smells like raspberries. But it's just an exfoliator mask for your skin. Now these two things are Pita's vegan lip balms. And these are the only vegan lip balms I can find at the moment. But I will say that this is not really a lip balm. It's more like a lip gloss without the color and the glitter. And it just feels like solid coconut oil so you're gonna get through this really fast. But they do come in really good flavors like tangerine, vanilla, and mint. Oh god. That's the fan. I don't even know why I bought this, but it's by the honest company and it's their honest sunscreen lotion. And it's SPF 30 without all the chemicals except it smells like grass. That's when you know it's really natural when it smells like freaking grass. And the last product is by Nature Love and it is their vegan deodorant. And this one is in the scent Lavender Fresh. You don't know what deodorants really do to your skin. They have aluminum in them and that can lead to cancer and all that bad stuff. This one's not tested on animals, but it works. And literally I have not turned this tab. It has been like this forever.  I freaking love it. And if you enjoyed it please give this video a like, leave a comment down below, or subscribe. I'll see you guys later. Bye!


Israel strikes Hamas tunnels and weapons factories in Gaza. Israel has struck two tunnels and two weapon production sites in the Gaza Strip in response to Hamas security violations in recent days, the Israel Defense Forces reported in the early hours of Friday. The IDF holds the Hamas terrorist organization responsible for all terror activities emanating from the Gaza Strip and it will face the consequences of the security violations against Israel, the IDF added. Breaking rocket alerts were activated in open areas along the Gaza border a short while ago. According to the reports, missile sirens are sounding in the towns of Karmia and Net of Hasara on the north of Gaza Strip. There are no reports on the injuries or damage.


Guys, welcome back to my YouTube channel. This is Daniel Rosal here. This is going to be a video today looking at the key frameable volume option on Caden Live and explaining why that's useful and just to also offer another way of doing this. This being you have two audio tracks in Caden Live and one of them is background music so I've just grabbed a bit of background music there from the YouTube audio library, the free music and the second one is narration. So when you have two audio tracks you may want to change the level of that background music so that at certain parts of the video it's the main audio source and in other parts of the video when your talent or subject is talking it becomes background audio because if it's playing at full volume you're not going to be able to hear the narration. So in order to show how this works I've put together a little timeline here based on a video I shot earlier in the week in Tel Aviv. It's me eating at an Indian restaurant and talking. So here's what I've laid out on the timeline. Just going to scrub through it here. I have a b-roll shot of the exterior of the restaurant nothing much going on there just showing what it looks like a little title. Then I talk for a little bit and then we have the same clip on the other side. Now this is me the audio here me speaking and I'm going to play a second of it. Now the problem we have here is that it's very difficult to hear me because of the background music. So I'm going to show you what I would consider a less ideal way of doing this and a better way of doing this. So the first thing I'm going to do is for this b-roll footage of the exterior of the restaurant I'm going to ungroup the audio and the video for that. I'm just going to actually delete the audio track so there's going to be no audio coming from the actual camera here we're just going to have the background music. So again I've done the same process ungroup that clip press the lead key and now for the start of this video we just have the background music and I'm going to just do a little bit of fading in on the intro and I'm going to do a little bit of fading out on the outro of this clip right so so far so good.  I would I'm going to zoom in a little bit here I would clip the audio where I want it to go down and clip the audio here and try to match it ideally to the exact frame that's pretty much it. So now I've clipped my background audio track audio to here is the music so I'm just going to give it a name to make this more clear and what it would do then is go into audio effects and you should see a gain setting and drag that on to the background music at the part of the intermediate clip where it's playing alongside the narration and then I would turn the gain down to something like 15 and I just listen with reference headphones to the audio and you know play around with the percentage until it's perfect the audio isn't too quiet but it's not so loud that it gets in the way of the narration. So that sounds good enough for the purpose of this demo so that is methodology one. Now what I'm going to do is actually go back a little bit I'm going to undo my work here I'm going to get rid of the gain and I'm going to get rid of the cutting and now we're back to kind of the start. Now what you can do as well is if you go into your audio effects the very last option under volume and dynamics is called volume key frameable. So I'm going to drag the key frameable volume onto the background music okay. Now I'm going to click onto that clip and we can see that we're able to key frame the gain. Now the advantage of this over the first method if you have remember what we did was we got rid of the music then we put the gain down to like 20% and then back to 100 so those transitions from 100 to 20 in the space of one frame it's going to it's going to be very stark there's not going to be really much subtlety to it. So we don't need to key frame the start what I can do is add a key frame a little bit before the narration comes in on the key frameable volume I'm going to add one here then a little bit after now you can play around with the best way to do this and I'm going to bring the gain all the way down to now I like the way it visually represents this right you can see well it's going to be pretty much full here and I listen to this so you can play around again with that floor is the floor too low perhaps minus 10 is better and then on the other side here we're going to want to bring the audio back up as we're coming to the end of the clip and we're fading back to that little bit of b-roll so I'm going to again click on the background music track and I'm going to add another key frame here I'm going to add a key frame just after the b-roll comes in and I can actually either create gain I can type zero decibels so there's no gain reduction or I can drag the advantage of dragging is you can be a bit more granular but I don't want to increase the gain to positive I just want to increase gain to zero db and that can be a little bit hard and finicky when you're doing with the timeline one cool thing is if that sounds too if it sounds too abrupt I can make this a more gradual gain increase by moving this forward a bit and moving this to the end a bit or if it sounds too gradual in other words I want the background music to come up quicker I can make that slope shorter so let's listen to this now and there you go so I've faded back to the music and now I can do fade out of the video so those are the two ways in kaden live I know of there may be others if you have two different audio tracks one of that one of those tracks is your background music track the other track is your narration and you want to bring down the music for a little bit and then bring it up for a little bit you can either directly apply gain cut up your background audio and put gain on either side it's going to work but the jumps might sound a bit too jumpy so if you want to do it in a more smooth way check out the key frameable volume effect and this can allow you to go very very granular in making those volume jumps with your background audio track hope this video is useful if you're a kaden live user thank you for watching if you'd like to get more videos for me about kaden live tech and many other subjects please consider subscribing to this youtube channel thank you for watching


Coronavirus cases continue to climb, with the country seeing a record daily jump. Nearly 98,000 cases have been reported in the last 24 hours, taking the overall tally past the 51 lakh mark. Now, recoveries have also increased by over 82,000 for the second consecutive day, while the number of deaths remain over 1,000 for the 16th straight day. However, replying to a question in parliament about how many healthcare workers have died during the outbreak, Union Health Minister Harsh Vardhan said the government did not have the complete data on the number. This follows a similar statement by the Minister of State for Health Ashwini Chaubey earlier this week. In response to those statements, the Indian Medical Association has published a list of 382 doctors who have died due to the disease and demanded that they be treated as martyrs. The IMA has responded to the junior health minister's statement, calling it an, I quote, an abdication of duty and abandonment of the national heroes who stood up for our people. End of quote. Now, reports have also emerged from states of Maharashtra, UP and Gujarat about hospitals grappling with an oxygen supply shortage as demand is more than triples. However, the health ministry has said that there is no shortage of oxygen for medical use, in fact, insisting that there is surplus production. According to health secretary Rajesh Bhushan, a little over 6 percent of COVID patients in the country were on oxygen support in hospitals and this includes 3.69 percent on oxygen support, 2.17 percent on ICU beds and 0.36 percent on ventilator support. Well, to discuss all of that and more, we'll shortly be joined by a panel of experts. Joining us now to take the discussion forward is Dr Rajan Sharma, the president of the Indian Medical Association, Viren Shetty, the EDN group CEO of Narayana Health, Dr Mohan Joshi, the dean of the Nair Hospital and Dr Sunil Karan, chairman and consultant of critical care medicine from Manipal Hospital. A gentleman, appreciate you joining us here on the program. Of course, the caseload continues to be a cause for concern. But Dr Sunil Karanth, let me ask you what we just heard there from Dr Joshi. He's, of course, talking about dealing with patients who are infected with COVID. I want to also specifically ask you about the challenges that frontline healthcare workers themselves are facing. You're managing hospitals, sir. How are you coping with this? You know, the expectation was that by now we would start to see a peak and we would start to see the caseload decline. That's clearly not the case. A lot of medical professionals that we've spoken to have spoken about COVID fatigue setting in. How are you dealing with not just patients who are infected, but health care workers who are dealing with the pandemic as well? Yeah, I think you have, you know, when you question, you have hit the point right on the spot, COVID fatigue is setting in, in amount of healthcare workers. And rightly so, there is a lot of uncertainty that we right now have with regards to the how long this duration of illness is going to go, how long this pandemic is going to continue. And with no immediate sight of a vaccine also, you know, when is this all going to come under control is the big question we have moving over us. I think one of the major concerns have been also that, you know, there are multiple mathematical projections which have been done right through and every time there has been a revision of this and we don't see an end, which is there very soon for this. So I think the initial enthusiasm, the effort which went in from all quarters, including the lockdown and the preparation that we have done now seems abysmally short, despite all the precautions and the preliminary work that we did because the case note just seems to be rising every day. If you look at the graph in different parts of the country, certain parts of the country where the infection was well under control has also now become a center of hotspots. And I think it's right, it's ravaging right across the country. And big metros are under a lot of pressure. We have people coming from the second aspect into the big metros. So we are really battling with a lot of cases coming in. The idea to do this is also the question of healthcare workers going off duty because either they are infected or they are unwell due to a variety of other problems. And there is a demoralizing effect that seems to be coming on a lot of healthcare workers. And if you look at certain front end specialities like pulmonology, ICU, ER, the community-based services, they have been relentlessly on the field for about five, six months now. And the last two to three months has been very, very cumbersome for the entire system. And we are very worried that it's a matter of time for the system to start scrambling. And to add to this with the unlocking, we are seeing other kinds of patients coming in. There are a lot of kinds of surgeries beginning to happen. They've got post-traumatization, they have started a whole lot of other infections which we often see in monsoon, which is also beginning to take us five. So we are now facing a double-edged problem. Correct, correct. We are really struggling to cope with the situation. Okay, the system is struggling to cope, not just with COVID, but now there is a rise in non-COVID infections as well. Dr. Sunil Karan, let me ask you about an issue that is currently being faced, which is the supply-demand mismatch. As far as oxygen is concerned, can you take me through what you are experiencing because you were also talking about how there is an influx of patients into the cities from tier two, tier three towns. We are hearing about the lack of oxygen. We know that a committee has been set up. There is the possibility of industrial oxygen being diverted to medical supplies. What are you hearing, Dr. Sunil Karanth? So there is a definite sort of suggestion that there seems to be some sort of shortage of oxygen. But I think more than the acute shortage, this could be a problem with distribution as well. Certainly there are, like in most other aspects of medical infrastructure, there is a lot of maldistribution of things. And I think many a time it is due to either lack of oxygen reaching the district headquarters on time, or it could be because of a mechanical failure or a problem which exists in the already existing oxygen plant. So I think it is a little difficult to say that there could be an acute shortage at this point of time. But my worry would be that moving forward, there is a possibility that we may end up having shortages if we don't look at this problem as a potential one. And also to ensure that there is constant supply of this emergency, what I would say as a therapeutic or a medicine, as important as you give such as the vital drugs as well as the cereals such as things. Because any time just from there, like just in the box, it's just a full state life. Okay, so manageable at this point in time, but it is something that we should watch out for and look at the distribution and inventory management as well. That is the perfect note to wrap this discussion on. And I do hope that policymakers are listening into what Dr. Rajan Sharma, president of the IMA, Viren Shetty of Narayana Health, Dr. Mohan Joshi of the Sine Hospital and Dr. Sunil Karanth of Manipal Hospitals have had to say don't force doctors into buckets of government and private. These are healthcare workers who are dealing with the pandemic on the frontline. They need to be treated with respect, with dignity, and they need to be given protection irrespective of whether they're private or government. Thanks very much for joining us here on CineBC TV. It's an appreciate your time. With that, it is time for us to wrap up the special edition of Restarting India. Don't go anywhere. We will be back in a moment.


Hello everyone, this is Alice Gao. In this video, I'll start discussing a new topic, reasoning and decision-making under uncertainty. So far, we've considered a world without uncertainty. In search and supervised learning problems, all the information is available to us, and we can use the information to perform inference and to make decisions. Why do we need to think about uncertainty in the first place? First, when an agent is navigating the world, the agent cannot observe everything. The information that's not available to us constitutes a large part of our uncertainty. Second, the agent, whether it's a robot or a program, it's imperfect. When the agent performs an action, the action may not produce the intended consequences. This leads to another possible source of uncertainty. Even though we're in a world with so much uncertainty, we need to take actions. We often have to make a decision based on missing, imperfect, or noisy information. The best thing we can do is to quantify our uncertainty about the world and use our uncertainty to perform inference and to make decisions. A student once asked me a philosophical question about making decisions under uncertainty in real life. The question was, suppose that I make an important decision and the outcome turns out to be not as good as I hoped. If I could go back in time, would I make a better decision? This type of what-if question can really keep a person up all night. What is your opinion on this? Here's my personal opinion. I believe that even if I can go back in time, I would still make the same decision. The reason is that, at the time, I did not have as much information as I do now. I made the best decision I could given the limited information that I had at the time. So even if I could go back in time, I would still make the same decision anyway. This is just my opinion. I would be curious to see what you think about it. Next, let me discuss two views of probabilities. We'll leave in a world full of uncertainty. Formally, we can use probabilities to measure uncertainty. When it comes to probabilities, there are two camps called the frequentists and the basians. The frequentists believe that probabilities are objective, something we can observe in the world. If we want to calculate a probability of an event, we can count the number of times an outcome of the event occurs and use that count to calculate the probability. For example, suppose that we want to know the probability that a coin will turn up heads if we do a coin toss. A frequentist will do many coin tosses and determine the probability as the fraction of heads observed. Basically, the probability is based on historical observations. The advantage of this view is that since probabilities are observable, it's something that we can agree on. The disadvantage is that a frequentist cannot estimate the probability if they haven't observed anything. In contrast, a basian thinks about probability as something subjective. A probability is just a degree of belief in our head. Basians believe that we have some prior belief about the probability based on our previous experience. As we make observations, we'll update this belief based on these observations. Consider the coin flip example again. Before observing any coin flip, two basians may already have different prior beliefs about the probability for the coin to turn up heads. These prior beliefs are based on their different prior experience. In general, different people can have different probabilities in their head for the same event. As the two basians observe some coin tosses, they will update their beliefs. The more coin flips they observe, the similar their updated beliefs will be. The advantage of the basian view is that we can have a probability estimate even if we haven't observed anything. The disadvantage is that two people may not agree on what a probability should be if they have different prior experience. In this course, we are going to adopt the basian view of probability. In order to use probabilities to model the world, we will need to come up with random variables. Each random variable describes an event. It has a domain which contains all the values that the random variable can take. There is an associated probability distribution which specifies a probability for each value of the random variable. Here's a simple example. Suppose we're modeling a scenario involving burglary and alarm. If a burglary happens, then the alarm may go off. One random variable could be whether the alarm is going off or not, and the domain would contain true and false. The distribution could specify that the alarm does not go off 90% of the time. In this unit, we will primarily deal with Boolean random variables. Each Boolean random variable can be either true or false. For Boolean random variable, we will use a simplified notation. We'll use a and not a to denote a is true and a is false respectively. There are some common properties that all probability functions satisfy. They're called axioms. We'll focus on probability functions that satisfy the three axioms below. The first axiom says every probability is between 0 and 1.  Any other number range would also work. We needed to restrict these values to a range so that they're comparable in different scenarios. The second axiom says if something is true, then its probability is 1. If something is false, then its probability is 0. The third axiom is the inclusion exclusion principle. We can calculate the joint probability of two events, a and b, using the given formula. When we add the probabilities of a and the probability of b, we double counted the probability that a and b both happen, so we need to subtract that. All of the probability functions we consider satisfy these axioms. Let me introduce two more terminologies. Remember that we adopted a Bayesian view of probabilities. As a Bayesian, we have a prior belief and we'll update this prior belief based on observations. When we have a probability with no evidence, it is a prior or unconditional probability. This is our probability estimate of x when we haven't made any observation about x. Once we make new observations, for example y, we will update our belief about x given the observation. p of x given y is called a posterior or conditional probability. These two terminologies go hand in hand. We have a prior or unconditional belief before observing anything, and we have a posterior or conditional belief after getting some observations. In this unit, I will use a story about Sherlock Holmes as a running example. Mr. Holmes lives in a high crime area where burglaries are frequent. Because of this, he installed a burglary alarm. However, Mr. Holmes is not always at home and he relies on his two neighbors to call him when the alarm is going off. Mr. Holmes has two neighbors, Dr. Watson and Mrs. Gibbons. Unfortunately, the two neighbors are not perfectly reliable. Dr. Watson is known to be a tasteless practical joker and Mrs. Gibbons has an occasional drinking problem. Furthermore, the alarm is sensitive to earthquakes, which may happen once in a while. If an earthquake happens, then it will surely be on the radio news. I will use this running example over and over again to discuss different concepts and algorithms. Our first task is to model this story using a Bayesian network. To do that, we have to define some random variables. For this story, it's sufficient to use Boolean random variables only. Once you come up with random variables, determine the total number of probabilities there are in the joint distribution. Pause the video and solve this yourself. Then keep watching for the answer. I came up with these random variables. Don't worry if you came up with different ones. Modeling a real-world scenario is a challenging task and it takes a lot of practice before you can do it well. In this case, I have six random variables for burglary, alarm, Dr. Watson cause, Mrs. Gibbons cause, earthquake, and radio. So how many probabilities are there in the joint distribution? It's 2 to the power of 6, which is 64 probabilities. We need at least 63 probabilities to represent the joint distribution. The last probability is 1 minus the sum of the first 63 probabilities. Later on, we will construct a Bayesian network to describe the story. You will see that the Bayesian network representation requires fewer probabilities to describe the story. That's everything on introduction to uncertainty and probabilities. Let me summarize. After watching this video, you should be able to do the following. Explain why we need to model uncertainty. Explain terminologies such as random variables prior or unconditional probability and posterior or conditional probability. Given a story, define random variables to model the important elements in the story and calculate the number of probabilities in the joint probability distribution. Thank you very much for watching. I will see you in the next video. Bye for now.