Greetings, everyone. This is James P. Madonna of Megalife 21 and Progressive Discussions. And before I go on to do my next video talk show, I am stopping by from my immediate area off Route 17 South in Hasbrook Heights, New Jersey, the one and only, the famous Bendick Steiner, as seen on the Jerry Seinfeld Netflix series Comedians in Cars Getting Coffee. That's right. It is in my close area and I love it here. Outstanding food, outstanding coffee and I will go in soon before I go on to do my next show. James P. Madonna of Megalife 21 and Progressive Discussions here. And aside from the famous Bendick Steiner in Hasbrook Heights, New Jersey, Route 17 South, right behind the famous Teterboro Airport where everyone with private jets lands who wish to visit New York City. We are right next door, directly next door to the famous Bananas Comedy Club in the Holiday Inn on Route 17 South in Hasbrook Heights, New Jersey. And there it is. The famous Bananas Comedy Club with a very highly rated Gabriel's Restaurant. Brother, is that true? Now, you see how better to swing as you are right when you have a real light dental floss? Wow. You know, why lie to me, man? Yeah. Yeah, my mom was an owl. She loved owls. She had owls in the household.  Well, you know the bohemian, the infamous bohemian grove where all the elite meet once a year? They have a giant owl statue called Maltec or Ultec or something.  Well, they're known for wisdom, you know. I want to know, well, this was the best amulet they had. I was there yesterday. I was looking for more. They had two, they had the hands which I already gave you. Okay, but what do you want to know? I want to know, well, with the new information that came out this past week, would Robert Mueller really get close to nailing Donald Trump? Well, I think he's probably already close to see. Down the road, all this investigative stuff going on with Robert Mueller trying to pin Donald Trump. Is Mueller going to nail Donald Trump's? Because the new information is a new person that's going to testify. Like really? No, a man who has audio recordings of Donald Trump saying things that would definitely incriminate him in this case. Who, would you give Donald's CNN? No, no, actually it was. A Wolf Blitzer and Chris Cuomo mentioned it. They didn't like, they didn't say a lot about it because it's brand new. Well, it's brand new. Yeah, but he's going to go before Mueller. Who's Donald Trump headed for a downfall? You hear the latest Donald Trump speech about how great he's doing? Well, everything he does is great. He handled Puerto Rico fantastically. He threw some paper towels out of him. Yeah, he handled, he handled, the Caroline is fantastic. The border with ICE, yeah, right. The children are still not united with their mothers. And God knows where to sleep in cages on the floor. It's a warm air. This is cold. You know what? It's cute, huh? I mean, you never know what I'm going to find there. It's nice. They had different stuff. Where? The dollar zone, where I got the same Benedict's medallion. What about the Dollar Tree anymore? I buy things at Dollar Tree, but they don't have anything of interest, like unique stuff, like amulets. Isn't it amazing how the air conditioning is working splendidly when you don't need it anymore? When you don't need it to work. When it's a heat wave, you don't have it on. I know. But it's the same thing every year in this building. They just can't get it straight. They freeze people out. They don't give you heat. Well, I bet the Holiday Inn knows how to regulate a thermostat. Well, though you have the individual control. Well, you also have management with brains. But the lobby, the restaurant, everything else is always comfortable. Yeah. Well, I opened the window in my living room, because we face north of the house.  As soon as I opened it, whammo, I got the big breeze coming in. I go, good thing I shut the AC off, because I had no idea it was so nice out. But the rest of this week is going to be nice. It's going to be 70s. Yeah. And low 60s at night. Don't turn the air on. Go forget it. I've got your jacket. Yeah. Yeah, that was a lot of fun. That was a lot of fun going. Look at that. Oh, my God. That's what it's called. The Aviators, their football team. Yeah, it's a great name, because it's like... That's why the motif in here is all dressed.  I bet they get a good view, too. Lodi, that's the football team's called the Rams, blue and orange uniforms. Lodi Rams, I remember as a kid, they used to talk about the infamous team at Northern Highlands, whatever the hell, wherever the hell that happened. It's in Allendale, New Jersey. They said they were like really good. They were arch nemesis of... At that time in the 70s, Lodi, the Lodi team, they never looked forward to playing in Northern Highlands, as they get beat. And my drafting teacher, Mr. Benson, ended up being a Lodi high school principal. He was my drafting teacher. Woodshop and... No, he did drafting, woodshop and metal, I think. No, I'm sorry. Drafting, drafting, which I failed.  When I went, you had Macantan drawing? You got to really have a passion. It's like accounting. It's like, you know... Drawing. You know, beat numbers, numbers, numbers. I mean, it's great if you have that, if you have great mathematics skills and you become... But it's boring. You know... I can't see how Bob became... My Jeff is a... My friend, Jeff, from Canada, from Boston in Canada, he's a corporate controller. Accountant? Accountant, head accountant. I told him, I says, yeah, one decimal point in the wrong place and you're screwed. He says, oh, he says there's more to it than that than getting the decimal point right. I says, yeah, I imagine when you work as an accountant, you have to really focus on what you're doing. You know, it's a funny saying when they say, like, if somebody doesn't eat much, they're eating like a bird. Let me tell you something. When I throw scraps outside, the birds leave nothing behind. Right. Nothing. Well, they take a lot of small bites then because I find nothing. And they eat everything. Even if it's whether it's rice or bread or strips of my mother's meatloaf that she doesn't feel like eating. Today she's eating. Well, I serve it's pie. Stopper chop it's $6.99. Well, let me tell you, I think it's really assenheim that all these tells me it's out of season. You want to miss, like, it's a good size. Microwave. You have a microwave in your room? Yes. You know what? One of these days when it finally comes in, I'm going to get two of them and I'm going to give you one. If you like a big shepherd, I mean, one of the best I had at Blackjack Mulligan and say it was big, but all of these is not bad.  Two or three times. She doesn't acknowledge what she eats anymore. She's at the point where you put something in front of her and she just eats it. She doesn't discuss it. It's really hard watching them get old, you know?  It's heartbreaking. But a shepherd's pie, I mean, I never really I don't know why more restaurants don't offer that because I never had shepherd's pie until much later in life. I mean, I never heard of it. Why did you pick it up for you? I'll give it a shot. Tell me. You want to try it? You want a box of Salisbury Steaks from Aldi's? You like Salisbury Steaks in Brown Gravy? Why don't you want it? It's kind of like peasant food to me. Rubbish, rubbish. Remember in your apartment building in Ridgewood it didn't say garbage. Rubbish. That's Thurston Howl the Third Talker. Hey, I look like St. Patrick's Day with his ship. Am I as a shepherd's pie? Fish and chips. They got great fish and chips at Blackjack Mulligan's. They use like ice a lot worth of creatures and long-grown silvers. Especially when you get the steak French fries, the wide ones. Oh, man. Sometimes here they undercook their fries. Under? They're soft.  I do too. John looked like he had more skin surgery. He didn't look too bad. John, the Catholic? I didn't think he changed at all. The Catholic? Damn. I don't think it's a surprise that we'll head out. I'm going to have to wear my vest next time I come here. Something in the car just in case. Well, it's going to be like vest weather anyways. It is vest weather. It's not good. Yeah, I take a vested interest. This is really pretty. This is Mario yours. Oh, thanks, Jimmy. No. Thank you. We have to go over there and try the calamari. What time you got? Five o'clock. Oh. I didn't bring enough cash for a beer. If you want one, I'll get you one. All right, let's go over there. Let's go over there like we did last time. And boy, it was like a maze coming from Gabriel's to get to Ottawa. I didn't realize, I mean, it was a little tricky. But you know those Ottawa's apartments, they're kind of like cozy. The ones that are back there. You know, like secluded and everything.  It's a big box. It's really low, low price. And they look like they're good size. Salisbury sticks. Bigger things? Yeah. This has been a Mega Lab 21 production. Look at this. Commodore Jeff Zanbello at the Holiday Inn in Hasbrook Heights, New Jersey. Look at this. An actual hookup for electric cars. This is the first. This is the first right in front of the place. It's amazing. I've never seen this before. How about that? Well, that's it. That's it for today's show. The Bananas Bananas Comedy Club. Gabriel's Gabriel's Restaurant. The famous Holiday Inn. Route 40. No, I'm sorry. Route 17 south Hasbrook Heights, New Jersey. Teterboro Airport. There we go. And here's the fountain. Here's the fountain. I'm finishing off today's progressive discussions. Saturday show with the beautiful fountain. Here at the Holiday Inn in Hasbrook Heights, New Jersey where many European tourists stay that want to visit New York City and save money here as well as the pilots from Teterboro Airport where all the private jets land. All the big shots that want to visit New York land at Teterboro Airport is the place to be. The Holiday Inn in Hasbrook Heights is the place to be. This is James P. Madonna saying until next time progressive discussions. We'll be with you with more insanity, comedy or hard hitting truth. Or sometimes a combination of all of them. Very relaxing. You know, moving water according to ancient Feng Shui in China represents the circulation of money. Maybe that's why they have a fountain in front. Who knows?


Dear students, in this topic we shall discuss the non-tropic hormones of adenohypophysis. Adenohypophysis secretes three hormones that act directly on their target tissues. These include melanocyte-stimulating hormone MSH, prolectin-ERL and growth hormone GH. It is also called as Sumetotrophin. The melanocyte-stimulating hormone, or MSH, is a peptide hormone. In lower vertebrates, large amounts of MSH are produced from the intermediate lobe of pituitary. In humans, MSH is produced from par's intermediate of anterior pituitary in extremely low quantities. The MSH regulates the activity of pigment-containing cells, that is, melanocytes. That is why its name is Melanocyte-Stimulating Hormone. These melanocytes are found in the skin of many vertebrates. This hormone stimulates the synthesis of black pigment melanin by melanocytes. In these melanocytes, not only this is synthesized, but its dispersion is also controlled by MSH within the melanocyte. If this disperses inside the melanocyte, then the skin's color becomes black and if it is concentrated, then the skin's color becomes light. That is why it affects the melanocyte. This leads to the darkening and lightening of the skin color. Melanocyte-Stimulating Hormone is not produced in humans, so the pigmentation of the skin controls the acth, adenocortico-tropic hormone. MSH plays some roles other than controlling the melanocyte. For example, in mammals, it also affects the hunger and inhibits the act of hunger by acting on some neurons in the brain.  Prolactin has diverse effects in different vertebrates. In birds, it regulates fat metabolism and reproduction. In amphibians, it delays the process of metamorphosis. In freshwater fishes, it regulates salt and water concentration. While in mammals, it stimulates mammary gland growth and milk production. Dear students, now we shall discuss growth hormone in detail. The growth hormone is also known as somatotropin and somatotropic hormone. It is a protein that contains 191 amino acids in a single chain. The production and release of growth hormone is under the control of two hypothalamic hormones. One is the growth hormone, releasing hormone that is GHRH. And the other is the somatostatin that is growth hormone inhibiting hormone, GIH. The growth hormone exerts both metabolic and developmental effects. First, we shall discuss the metabolic effects of growth hormone. Growth hormone induces mobilization of stored fat for energy metabolism. It stimulates fatty acid uptake by the muscles. It also decreases the rate of glucose utilization. As a result, it causes elevation of glucose in blood. Growth hormone also increases the rate of protein synthesis in most cells of the body. It also stimulates insulin secretion. Insulin secretion is directly or indirectly caused by growth hormone. Directly this way, it acts directly on beta cells of pancreas and stimulates insulin secretion. This is the only trophic effect of growth hormone. Otherwise, all other effects are non-trophic, but this is the trophic effect. Indirectly, insulin secretion increases glucose levels in blood. When glucose levels are high, insulin is produced. Overall, growth hormone enhances body proteins. It uses up fat stores and conserves carbohydrates. Now, we shall discuss the developmental effects of growth hormone. It causes growth of almost all tissues of the body. It stimulates RNA and protein synthesis and promotes the growth of tissues, particularly cartilage and bone growth. The growth of tissues due to growth hormone is because of cell division. That is proliferation. Increase in the number of cells. There are two ways of growth. 1. Increase in the number of cells and 2. Increase in the size of cells. This increases the number of cells. Growth hormone works synergistically with thyroid hormones. It promotes tissue growth during development. Growth hormone also stimulates liver to produce growth-promoting factors. For example, insulin-like growth factor, which is called IGFs. IGFs act directly on cells to promote growth. Growth hormone also produces such factors. Growth hormone is very important in the developmental processes of animals and humans. Its undersecretion or oversecretion has drastic effects, which lead to abnormal growth and development of the body. There are three major human symptoms that are caused by the level of growth hormone disturbance. 1. Gigantism Excessive size, excessive stature. If growth hormone is more secreted in the amount of childhood before puberty, it increases in growth hormone. 2. Acromegaly Acromegaly increases the secretion of growth hormone after puberty. As a result, the bones of the head and extremities become longer. This is called acromegaly. If the secretion of growth hormone is less than the age of development before puberty, it produces dwarfism. Stature is short-lived in common language. That is because of the deficiency of growth hormone.