Okay, very good morning. Happy Friday the 19th of February. I hope everyone's had a good week Usual routine going to get up to speed look across the charts and some of the headlines from overnight to hopefully give you a bit of a Framework from a fundamental perspective for the day ahead But overall we had a lower close on Wall Street last night We closed down 0.44% in the S&P around a similar margin the Dow and the Nasdaq So fairly broad but moderate losses seen in the US and that then followed on into the Asia Pacific Session Generally lower in the region But as you can see here in the center charts got the DAX left Nasdaq center S&P future on the right We've had a bit of a kind of u-shaped recovery in some of the short-term price activity So it's one of the first things I wanted to kick off on was this idea that this week I definitely feel like there's been a lot more conversation or focus in the media about you know our equities Jew for a bit of a pullback is the catalyst of that rising yields And that's making you know some people nervous about the ability for this market to sustain its current rally and Know an observation we talked about quite a lot is a kind of short-term dip buying and the aggressiveness of reversals And there's a few things here for one You know the the behavioral pattern of price movement that markets move faster down than they do on generally the grind back higher And yesterday was a case in point. You know, we have the jobless claims albeit Showed a deterioration in the situation in employment in the US jobless claims were above the top end of the estimates and the market came down quite quickly However, you can see here by the close on Wall Street We've taken all of that back and we've seen that on the number of occasions I mean if I just quickly put an ellipse around kind of here was yesterday This was earlier the day before the day before This was then going back to last Thursday Then it was the beginning of last week Now nearly every occasion This market goes down and almost the more violent it goes down the more violent It kind of springs back. I mean you can see here certainly in the last two sessions Definitely, you know, I wouldn't think or say that this strategy is kind of bulletproof But I think for me when you're asking that question about how does the generally the market feel overall on the balance about The the sustainability of the equity move higher I think a lot of the the reaction effect to when markets move down says it all really I think key levels to watch here are important We haven't yet over the month of February really once we broke above and out of this top end on the 5th of February It's been a pretty decent level. You can see we have Snapped through it but failed to close below it on a couple of occasions on the 10th the 11th and also yesterday's session So that's going to be a key one to look out for Over the kind of medium term quite well above there at the moment and as long as that holds I think at the moment this S&P has got a floor under it to help support it But even then, you know, if we start to pull back lower and there is more aggressive corrections And I think still probably the next level here that's most clear You'll get a degree of of dip buying and people will come in if there is an aggressive About turn in this market and you know just looking here in the S&P 3860 you've got those previous but would have been all-time high double top the break and test support on the end the push-up Which is seen as the next level so Yeah, I've not I've not lost the faith just yet Is my current perception as far as the more near-term price action is concerned again, we have been Edging down that the kind of highs are becoming lower at this point So definitely be interested to see how we play out in the US indices later on today, but yeah Back to flat basically and the DAX future in fact slightly positive. We did have in a DAX Slight breakout this morning over a trend line with the last 48 hours price action first thing We've come back down. You can see there to just test back on the trend line here This morning. So maybe you just worth keeping a half an eye on here on the DAX as well any further break on the upside There you've got around that area of those those two price points that were highs in the morning of yesterday's session And that'll be at 13 953 and then the higher move above The high that was seen kind of mid-week and then the R1 just above it Should we continue any upside there in the DAX? otherwise in the currency markets Going to go back to that chart We've looked at number of times this week, which is a dollar index over the long term Which is that trend line which I think continues to be particularly important to watch Particularly this morning where you've got the eurozone flash PMI data points Which could just be enough to given the fact that we're sat right on that trend line And it's been so important for this week really price activity in these major pairs Whether it being resistance at the end of last week beginning of this week or support as it has done over the course of the last Two sessions Now if we were to get a really strong surprise in the eurozone PMIs is that enough then to bump then the euro up Consequently the dollar down through that trend line We start to see some some continuation of the general lower trend We've had over the last 24 hours in the Dixie if that does happen Well, what does that translate into well in terms of cable here? Cable has a really nice level of support at 139 53 looking at the sterling future here That played out really nicely actually in fact in the overnight Asia pack session You can see here the response We've had a decent 40 pit reversal of that back to the kind of range high that we've been printing for this week And of course in close proximity of 140 so any push above the upper boundary of that price action later on today 140 is the the kind of psychological target above there Otherwise in the euro similar kind of setup where We've got a pretty decent line here of near-term support to price If I just move this over so you can see the areas I'm looking at here going back to the Kind of eighth ninth of the month The support area on the 12th again on the 17th before the break down the backup for the kind of pullback on the classic Before then the move back lower. And so yeah 120 89 Good level of support getting the overnight Asia pack session based on those previous reference points And as I was just saying this upside level here, which you can see has has some Previous area of significance as well for price would be key to keep an eye on 120 104 So they would be a key things I'm looking out for again, just to be clear the PMIs are strong Which would be probably a decent type reaction in euro appreciation if the German French figures are that way Because I would say on the balance the consensus estimates are for a slight deterioration from the prior month Given the fact that really Vaccination rollout in Europe has been relatively slow number of those big economies are still in fairly strict lockdowns at the moment So one would think that the market's probably erring on those numbers on the side of pessimism So a positive surprise probably has a high impact value and if that does then materialize It would be quite interested to see if we do get any kind of break above those levels and then maybe a push back up You've got the R1 sat here at 21 kind of 19 just above there would start to bring in some of that range play as well from Last week and the week before up here So yeah, definitely quite interested to watch the currencies this morning otherwise elsewhere Oil prices definitely quite key. Let's let's let's literally drill down into that a little bit more and and talk about that in more detail so the the story of this week has of course been what's been going on in the US where Record low temperatures have basically resulted in a huge unprecedented loss of oil output in the US Tantamount to 40% for zero and that has then seen a dramatic rise in a lot of the energy space that gas oil prices and So irrespective of what Saudi are saying about reestablishing let's say million barrels per day of crude Really that pales in significance in the near term because the more Existential impact on supply and demand is coming from a huge monumental size loss of output short-term That's being witnessed in America. So we had a big ramp up obviously going into What was towards the end of last? Week and then we've kind of remained bid as well over the course of the last two days And then yesterday we we sold off quite aggressively now a couple of things I can update you on on this This is some of the headlines them The Texas oil patch is slowly restarting wells after the deep freeze So marathon oil Devon energy Verdant oil have begun using restored power from local grids or generators to restart output across the Eagle Ford Shale Basin that was halted by the frigid weather according to people familiar with the matter now a couple of things here then Oil traders and executives has said they hoped that most production lost will return within days And the reason for that is as temperatures rise and power becomes available They have warned that a small percentage may still be shut down longer due to repairs but that does then lead to the question of of weather and You know some of the discussions that Tim and I were having with the community on Amfly live yesterday We're about okay. What's the best ways and means of tracking this type of thing and the National Weather Service? I would say If you if you're not in the ability to pay money to have privileged access to a lot of the more granular level deep detail The National Weather Service do a pretty good job At putting out fairly frequent updates and giving you forecast projections over different time frames like 4, 8, 12 Going out to 2, 3, 5 days out temperature patterns. And you know, this is it here. So their latest update They're slow warming can be expected across the southern US going forward So temperatures are beginning to moderate in the south And so this is what's acted as a bit of a bearish factor for crude oil prices in the last several hours And that's seen the price go from north of 62 in the front month futures down towards, you know sub 59 in a price point now couple of other things then we mentioned just briefly there that Marathon Devon verdant oil they're looking to restart output across the Eagle Ford shale basin now I guess a good thing to become more familiar with then is to kind of lay of the land as far as the lower 48 states shale plays and If you're looking down here Eagle Ford is here and you can see most of this then Concentrated in the area around Texas. So Eagle Ford you've got the Permian basin, which is the largest You've got the Anadarko basin sat just above there as well. So, you know when you're mapping US oil production in and weather temperatures It's kind of similar to when you're looking in the Persian Gulf and the Straits of Hamoos in terms of let's say Geographic sensitivity. So here the geography would dictate where the the kind of deposits in the basins for shale which you need to track and so Whether or not here on the National Weather Service there continues to be very cold Wintery mix in the Mid-Atlantic northeast area. That's probably not so important because actually when you look at it It's reason why the Texas oil patch has been particular focal point. So hopefully that Makes a makes more more sense In terms of estimates a couple of things that a few banks have said Goldman Sachs kind of ratifies this this thinking saying that the deep freeze in Texas will only have a small and transitory impact on the global oil market estimating an average decline of 700,000 brows per day in February production of the lower 48 onshore crude States due to a pickup then and rebound expectations on warmer weather Expected to materialize by this weekend Citigroup estimate that as much as 1 million brows a day of Permian basin oil Output could remain offline though over the next 10 days So all in all, you know, how how would you look at oil this morning? Well? If you X out this this kind of energy Reaction will then really if you look at where we were training before some of this recent elevator price action materialized We were training around a 59 Handle and that's pretty much where we trade at the moment. So a lot of that Weather impact I do think is transitory I don't think it's long-lasting and these facilities will come back online And if there is any need for repairs or there's a period a city say of 10 days for some facilities to come back online The point being is they will come back online. We don't need to wait 10 days. The market will already price that in So I wouldn't be here thinking right. They're short. This market oil prices are going to collapse further and start Unwinding that that was the trade yesterday as Tim and I were kind of covering live At the time remember when it comes to weather tracking markets are very forward-looking And so hence the reason why we came quite aggressively off the highs yesterday Okay One other thing to mention on the geopolitical front, which I guess has some connotation for oil is about Iran The Biden administration is said to be willing to meet with Iran to discuss a diplomatic way forward Now this would be meaningful because of course Donald Trump pulled out of that accord back in 2018 much to the dismay of not just his aggressive administrative approach to Iran and But also the relationships on the issue with the likes of mainland Europe. So particularly France Germany and others So this goes some way of restoring Some of those severed links Something to just be aware of obviously this is very early days, but we'll see how that plays out But again, remember it was Obama who managed to broker that deal of which of course Biden was part of that of that particular team When they struck that accord the nuclear agreement in 2015 All right quick look at the Calendar for the day ahead Hey, you've already had the UK retail sales report come out the Month of month minus 8.8 percent versus expected minus 2.6 percent. This was for January data Now importantly, you can see look the pound hasn't really reacted and it's in it if anyone is new to markets This is why You've got to apply context to the news that you see you can see very momentary little blip couple of pips in Sterling and then reversed at the moment the key thing here is I think these these FX pairs could be really interesting If we get some slightly upside numbers as I said those PMIs that bump the dollar back down through that level I think we could see some decent upside and I'll be looking for that 140 test If not beyond in cable under those circumstances Now the reason why I'm saying about context with the sterling retail sales numbers is look we're in a national lockdown at the moment You know things are improving vaccinations are going good so far But you know, I don't think anyone had an optimistic view about the state of retail sales in January So it's just really not a surprise at all And that does go some way as well as understanding how the market generally is probably positioned for these Upcoming numbers in the flash European manufacturing service PMIs is that these generally Probably will reflect more broader expectations of pessimism and so hence our upside surprise might be quite interesting On that note, it's worth just saying that whilst I've been talking the euro in fact has now seen that breakthrough So you can see a little bit of follow-through here quite a nice pop on the breakthrough You know, let's just see how it performs. But Before looking to enter on the pullback there to get back long Definitely want to wait for the PMI data for confirmation because that data does have the ability to move the market quite substantially And it could go against your position very quickly. So you'd want to see the data there Otherwise just rounding off the calendar and other things that we've got we'll get the US equivalent Obviously for the PMI data at 245 so no major 130 is coming out of the States You then got Bank of England's Flager Barkin and Rosengren and the one I think I want to draw your attention to is Barkin I was just having a look back on my notes and back on the 11th of January If you remember it was at the beginning of that week It was the Barkin Bostick double team that started talking about the idea of having a discussion about tapering and that was what planted the seed then kind of Fueled a bit of negativity in markets about wow the Fed under this reflation review We're going to start talking about tightening and the markets didn't like it and ever since then literally the next day every Fed speaker and as per ratified in the minutes This week have come out pushed it back against that idea and they've kind of reinstalled this accommodative dovish stance so given that Barkin was The original or the originator of some of that thinking he has spoken a lot since the Richmond Fed president However, I'd just be interested to maybe keep an eye on that is part taking in a panel discussion at 1 p.m. London time Today it does have here on the calendar the Humphrey Hawkins testimony text release I'm I'll look to ratify that because I thought that was next week Obviously if it is this week it could be another Thing to look out for but largely a iteration probably of what pals been saying of late So no not anticipating any even if it is this today or next week Any definitive change in Fed comms just yet. All right, that is it a couple of things I'll be recording the latest market watch podcast with peers In an hour or so times to look out for that check it out over the weekend if you have time Don't forget to leave a rating and a review If you're listening to things like Apple podcast for example be much appreciated And then I've got a special treat for any of our YouTube community. There's gonna be a video. I'm releasing on Saturday So make sure you subscribe to the channel Hit the bell icon and you'll be notified as soon as that video goes live a midday on Saturday All right guys have a good session ahead. Have a great weekend and I will catch you in a discord room If you're not in there already, then I'll see you on Monday on YouTube. Thanks very much


This is stock number 9C24A. We are here at Summit Automotive in Fond du Lac, Wisconsin. You're new and used Chrysler and Chrysler Pacifica headquarters. Today we are checking out this extremely clean like new 2019 Chrysler Pacifica limited package. This vehicle has the 3.6 liter Pentastar V6 motor and has been fully inspected by our service shop as a fresh oil and filter change. All the fluids have been checked and topped off and this van is 100% ready to go. Red velvet pearl coat is the color we shoot all of our videos in 1080p, 60 frames per second. So if you have HD capabilities on your computer, tablet, or smartphone device, turn them on right now because it is like you are right here looking at the vehicle with me. And definitely your best way to check out the vehicle and ensure the quality and condition before seeing it in person. If you want to check out more photos of this van in the upper right hand party screen is the link right to our website so click that and check us out there. Comes with the 20 inch Granite Crystal painted alloy rims. Has Falcon ZX24550R20 tires with just about all the tread left on them. Didn't see any dents or dings on that front fender. Has the HID headlamps, the LED running lights, and the LED fog lamps. Front bumper is in excellent condition. I didn't see any dents, dings, cracks, or scuffs on that. Very nice condition. And that hood is in excellent shape as well. Didn't see any dents or dings on there. Passenger side fender, no dents, dings, or scuffs on that. And the passenger side rim is in really nice condition as well. Maybe one tiny little scuff on there, but other than that, very nice. As you go down this side of the van, very, very clean. Didn't see any dents or dings on the body. We take these HD videos so if you are far away, or even if you're close by, but just can't make the trip down, you can still see the vehicle, hear the vehicle, and have confidence in what you're looking at before you even get here. So you can make a smart buying decision from the comfort of your own home. And that's why we offer the Summit Auto Fastpass option in the upper right hand party screen. A link right to our website where you can apply for financing, get pre-approved, see a payment quote. Even appraise the trade off from the comfort of your own home. So when you get here, all you got to do is drive the vehicle and love it. Back tires are like new as well, and it does have four-wheel disc brakes. As we come around to the back of the vehicle, rear bumper is in absolutely perfect condition. No dents, dings, scuffs, or scrapes on that. Has the backup parking sensors, and you do get that little bit of gloss black centerpiece right there. You also get the Granite Crystal Limited Chrysler and Pacifica badges on the back. This is a power lift gate. Third row, Stow and Go seats are power fold down, so you press that button right there. And they're going to start going down like so. This is your Stowa and VAC system. It also has a tire inflator kit in here. No seats go down just like so. Nice and easy. You don't have to do anything other than press that button. And to get them back to normal, just put them like that. Press that, and there they go. Very nice system. They go really smoothly, and then they'll put the backrests up as well. And to get this rear gate closed, you press this button right here. It'll beep at you three times and then begin its descent. You get the LED tail lamps as well. And as you go down this side of the van, just as clean as that passenger side, rear quarter is in excellent condition. You can see any dents or dings in that. And it does have the capitalist fuel fill, which is a really nice feature. For full disclosure, this back rim is in excellent condition. You can see any scuffs or scrapes on there. And down the rest of this side of the van is very, very clean. It has the blind spot monitoring, directional signals, and heating elements in the mirrors. You have the entering Go system.  With the gray piping, you get the S emblem stitched into the backrest, part of the S appearance group. You also get both seats are power heated and cooled, and you get driver side lumbar. Factory floor mats throughout, auto headlamps, tilt, telescopic steering wheel, memory driver seat, power windows, power locks, power mirrors, and these mirrors also power fold in. You can see that both sides fold in and fold out nicely. As we hop inside the vehicle, this one only has 1,608 miles. You get a digital speedometer, outside temp, and compass display, as well as your clock. It has the heated leather-wrapped steering wheel, cruise controls on the right, Bluetooth and information center controls on the left. You notice you get the gloss black trim on the steering wheel as well. You also get that gloss black trim around the radio and climate controls down here. This is the 8.4 4C radio. This one does have the factory navigation system on it. It also has AM, FM, and Sirius XM radio capabilities. You can do your climate control here, and you can also do your heated and cooled seat buttons, as well as your heated steering wheel. This one also has the projection manager, so you can do Android Auto and Apple CarPlay on this radio, so you can project your cell phone to the radio, whether you want to use your own navigation system, or if you want to use it for your music on your phone or whatever, you can project it to the screen. Very cool stuff there. 9-speed automatic transmission, you get your start-stop capabilities. You can turn those backup parking sensors off, and you do have stability control that you can turn off as well. This is your electronic parking brake, dual climate control, and you can control all the air stuff there. Augs in USB, you also get a 12-volt power point and another USB port down there. You have your keyless entry, power rear gate, and your power side door buttons on the key fob, and it does have that enter-and-go system. Passner side floor mat and seat are in excellent condition as well. No rips or tears. This vehicle has never been smoked in, and it does have the glass roof, so you get the second-row fixed roof, and the power sunroof in front. You also have the third-row skylight back there, which we can check out in just a second.  You also have SOS and assist buttons in the rear view mirror, and you get your home link buttons for your garage door security systems and lighting systems. Very clean inside. We'll take a quick look at the back seats, and then we will check out under the hood. These are power sliding side doors. This one does have the stow-and-go assist, so there's a button in here right there. Press that button, and you'll notice that that front seat goes up. That's so you can get the stow-and-go seat down. Once that's up all the way, it'll stop, and then this comes up just like so, and it'll kind of sit there. Next thing you do is you grab that stow-and-go strap right there, and this seat will fold right into the floor. Then you just grab this latch right here, and you can put it down. Just give it a push, and it locks into place. You can see a nice, flat load floor. When you've got all the seats down, you have room for a 4x8 sheet of plywood, or drywall, or whatever you want to haul. It's like you've got a truck wherever you go. Third row seats are very clean as well. No rips or tears back there. Very clean. There's your stow-and-back system.  Very simple as well. Just like you started. Put it up like so. Grab the stow-and-go strap again. It goes up like that, kind of locks into place, and then that backrest goes up. Last piece, you put the floor back down, and it'll go like so. That goes down nice and flat. You press the stow-and-go assist button, and that seat will go right back to where it was originally. You also have the side shades. Those second row seats are heated, and you get rear air controls. You can see that door slides nice and smoothly. And we'll take a quick look under the hood. I would personally like to thank you for checking out the video today. And hopefully from this HD video, you will have been able to tell just how clean this van is all the way around inside out. Under the hood, we have the award-winning 3.6-liter Pentastar V6 motor. This vehicle has been fully inspected and inspected by our service shop for the State of Wisconsin inspection process. It has a fresh oil and filter change. All the fluids have been checked and topped off. And this vehicle is 100% ready to go. To see more pictures of this van or one of our other 450 new and used cars, trucks, SUVs, minivans, wranglers, halftons, three-quarter-tons, one-tons. You name it, we got it. Go to our website, www.summitauto.com. Full pictures and descriptions of every single vehicle from two locations all at summitauto.com. And if you'd like to check out more HD videos, you can go to youtube.com slash summitauto. Remember to like, subscribe, and share on this video and all the videos that you see there. In fact, in a second, you will see links to subscribe to our YouTube channel on your left. For Pacifica minivan videos like this one on your right, if you've not been to our website on the bottom link to this vehicle on our website, click those, check us out. And we really look forward to helping you with this extremely clean 2019 Chrysler Pacifica Limited S appearance group. Thanks again.


Hello, I'm Richard Schwartz. I am a professor in the Department of Microbiology and Molecular Genetics at Michigan State University, and I recently published a paper entitled Benzophenone 3, Promotion of Mamory Tumorogenesis' Diet-Dependent. This work and the whole project associated with this started a number of years ago with some studies on the impact of a diet high in saturated from red meat, something like lard, and its effects on mammary tumor genesis. And it was a fairly successful study showing the impact of high-fat diet in promoting tumor genesis, and in showing that, in fact, there were both pubertal and adult windows of susceptibility to high fat. At the instigation of National Institute of Environmental Health Sciences, we were prompted to extend our studies into chemical toxicants in the environment when the time came to extend the project. And my collaborators and I were thinking about critical toxicants in the environment that were understudied, and we centered on Benzophenone 3, which is the major ingredient, active ingredient in North American sunscreens. And there is existing literature on this chemical having either estrogenic or anti-estrogenic effects in a variety of cell culture and in vitro systems. And thus, it seemed rather interesting in the context of mammary tumor genesis, essentially anything that mimics estrogen may have an impact. We thought it was a good target, led to funding, and we examined this chemical in the context of different diets, changing the exposure to a high-fat diet from a high level to a low level, examining exposure during puberty and adulthood, and essentially two-factor examination of tumor genesis and looking at the interaction between Benzophenone 3 and diet in either promoting or inhibiting the tumor genic process. And the product of those studies to this point has been published in this paper in Anka Target. It proved fruitful the investigation. We found the biggest message we have is that Benzophenone 3 is very biologically active in the system. It was actually, even though it's a sunscreen chemical, it was provided in the diets of the animal, but we dosed them at a level that produced excretion in their urine that would be similar to the amount of Benzophenone 3 that you would find excreted in the urine of humans who had high level of topical exposure to commercial sunscreen. So we think it has relevance to human exposures on that basis. What we found was that the exposure to BP3, Benzophenone 3, affected the course of tumor genesis in all of the diets that we investigated, whether a high-fat diet was provided in puberty, in adulthood, or whether an animal was maintained on a low-fat diet, but the specific effects that we saw in tumor genesis varied with diet. The effects were rather complex, but in balance, the effects all seemed adverse. So on a low-fat diet, for instance, we found that the presence of Benzophenone 3 actually reduced the incidence of tumors, but the subclass of tumors that was less differentiated and more aggressive showing a morphology indicative epithelial to mesenchymal transition, the ability to metastasize presumably even though we did not directly test metastasis. We found that tumors that had this kind of morphology, even though on a low-fat condition there were fewer tumors with BP3, they were tumors that had a significantly higher rate of proliferation and a lower rate of apoptosis, which are both going to be adverse parameters in tumor genesis. Those are properties that are going to be scored when you're scoring human tumors. What is the rate of proliferation? What is the rate of apoptosis in the tumor? And seeing an increase in proliferation decrease in apoptosis is certainly adverse. So even though under those conditions there were a few tumors, the tumors looked more aggressive. When we looked at animals that had a high-fat diet in adulthood, we actually saw an increase in the incidence of epithelial tumors, tumors that still showed a lot of the differentiated properties of mammary epithelial cells and a morphology similar to mammary epithelial cells, but with BP3 rather than on the high-fat diet, rather than seeing a reduction in the incidence of these tumors, they were increased and they were additionally more proliferative than they were in the absence of benzophenone 3. At the same time, we did see the similar reduction that we had seen in the low-fat diet in the frequency of the spindle cell tumors, the more aggressive tumors. It's obviously a trade-off and a complex one. If you translate it to humans, would you trade off a higher incidence of epithelial tumors if you saw fewer really aggressive tumors? I can't really answer that question, but what I can say is that the indications of biological activity that changes tumor outcomes often in an adverse fashion suggests that we really need to dig deeper into the mechanisms that are altering tumor genesis when the animal is exposed to benzophenone 3. There should be some caution in the use of sunscreens that would contain benzophenone 3. Where are we headed on this work? I mentioned that we saw an increased incidence of tumors when mice were exposed to benzophenone 3 while they were on a high-fat diet in adulthood. One of the things we notice in those tumors, we saw that they were more highly vascularized. We also noted several gene expressions that are associated with angiogenesis and vascularization that had alter levels of expression in the presence of benzophenone 3. One future direction is examining how benzophenone 3 might alter the expression of genes involved in the process of angiogenesis. The other thing that we noted in our studies that is certainly worthy of follow-up and it relates to this converse result that we saw with the more aggressive tumors where they seem to be somewhat inhibited by the presence of benzophenone 3. What we see is that the epithelial tumors themselves have lower expression of genes that are associated with epithelial to mesenchymal transition, the advanced progression of the tumor to this more aggressive state. And that, in fact, is consistent with a more well vascularized tumor. Lack of vascularization and an anoxic state can often be a selection towards EMT epithelial to mesenchymal transition and progression of the tumor to a more aggressive state. So these are things we hope to investigate and look at the complexity of this mechanistically. Another take-home message besides caution and using a chemical like this that's prevalent in sunscreens, and I will say that exposure to this can be found in urine samples from 98% of the American population. But another thing that I point to here is that when we look at toxicants, the outcomes vary with diet. And I think it highlights the importance of testing the biological effects of toxicants across a range of dietary conditions. There's a tendency, I think, to set up experiments where we just look at the effects of toxicants on on mouse chow, standard mouse chow. And we may miss effects in doing that. The interaction with diet is clearly encourages us to be looking at toxicants under a variety of dietary conditions before deciding its adverse effects or its benefits if they're out there. And we hope to get more funding for another round of research trying to get at the mechanisms that lay behind the effects of benzophenone 3 on emergenesis.


The fiery horse with the speed of light, the cloud of dust, and the hearty high old silver, the lone ranger. With his faithful Indian companion, Tonto, the masked rider of the plains led the fight for law and order in the early western United States. The stories of his strength and courage, his daring and resourcefulness have come down to us through the generations. And nowhere in the pages of history can one find a greater champion of justice. Return with us now to those thrilling days of yesteryear. From out of the past come the thundering hoofbeats of a great horse, Silver. The lone ranger rides again. One silver, a danger on the trail ahead. One silver! Some distance off the trail that led down from the Wooded Hills toward Mountain City, center of the northwest fur trade, two men lay below the crest of a narrow ridge. Screened by thick brush, they lay tense and motionless. Their eyes were fixed on the narrow trail below them. And so were the two rifles that were loaded and already aimed. Over their heads a blue jay screamed. They figured the range was about 50 feet. That distance we can't miss. We can put our bullets right through them. Yeah, I never did like that engine. And I won't have to. He'll be dead. It is a fur you'll be carrying. Say, Sarelle, what did you find out that he'd be packing fur is toward Mountain City? Look, it's spring ain't it? All the fur trappers bring in their catches, Tonto. Sure, but how did you know it? Well, you talk too much. It shed a worsen that blue jay up above us. Oh, I asked what for it. Savvy, you and me are going to ambush this engine. We're going to take his furs and sell them. We'll get good cash for them too. But how I come to know he'd be on this trail at what time and what it'd be carrying, that's my business. It won't be so easy selling furs. Why not? That new town marshal is a tough hombre. Madeleine won't bother us none. He won't know where them furs come from. He knows, Sarelle. I reckon you know what you're doing, so I'll stop. I hear something. We're going to take the furs. Yeah, walking hoofs. Must be the engine and a couple of pack horses. No sign yet. They'll be coming around the bed right soon.  Sooner or now. Yeah, that's a blue jay. We should stop the screaming. Sarelle, there's a horse. He didn't blaze us. He's gone. He turned tail and headed back out of sight. His shots weren't involved. It wasn't me. I didn't squeeze the trigger. Don't be local. I know that. But some hombre must have spotted our ambush.  It must have been the marshal. I don't know. But whoever it was, I ain't staying here. Faster! It's all right. It's fine. Stop me. You let me shotgun me tunnel, tunnel with man. You, you Indian like me. I believe you. I'm Saskia. Oh, how? Saskia, you're heading straight for an ambush. Tell them I fired those shots across your path to make you turn back. Ambush? Yes. Then you hear the blue jay? Ah, blue jay, him watchdog of forest. He make plenty chatter. Let you know trouble head. That's true.  You're used to the forest. I didn't hear the blue jay's warning. Saskia, you dream as you ride. Not pay attention. Who outlaw would shoot me? We didn't see them. We follow them now. My horse first. No. No? We could catch them easily. But I don't want to because they're just working for someone else. Someone more important. Later on, tunnel I can follow their trail. And we'll see where it leads. Map right. You have two pack horses. Those are furs. Yes, white brother. I have fur trapper. Go toward mountain city. Sell or catch. I have two fur companies in mountain city. Great western and the webster. Whom do you trade? I not like webster company. That's answer enough for me. You've got only two pack horse. This all you trap all winter? No. Back in mountain I have cabin. Have more fur there. I have black fox fur. Black fox? I suppose like that would be worth a fortune. Oh, that plenty good. You got black fox skin? I have three. Oh, you have plenty good hunting, my brother. Time to hope you will... Gallo! It's Gallo! Who that? It's back up the trail. A woman. That sound like running forn. My wife. What is wrong? Why you not stay back in cabin? Trouble my husband. The pelts of the black fox. Gone. What? They gone. Stolen. But that cannot be. I never find out about us standing here on the trail. Tunnel. Up on the ridge where we heard that blue jay screaming. Look around until you find the tracks of the men who attempted this ambush. Follow them. Tunnel to what? Three of us escape. You are heading straight back to your cabin. Silver. Silver. Silver. Silver. Silver. Silver. Here, cabin. Where were those furs kept? You come. I show you. Here, in corner, behind fireplace. I build cash for furs. So. You see my husband? It's so. Pelts of black fox gone. Here's a big cake of fey. We'll head into the back room early. There's a gem there I'm aiming to see. So there we are. You know the horses are hitched. Follow me. Well, what's eating you? Nothing, sir. I'm just looking along on back trail. For what? It's nighttime. You can't see nothing. I had a kind of funny feeling there was someone following us. Look, we stepped away from that ridge of slickage, please. Yeah, I reckon so. Yeah, come on then. Honey. I've been doing business with you alone. Who's this man? Honey, Mr. Settley. You know me. My name's Burley. Yeah. So that's it, huh? I kept asking Sorrell who we'd sell them furs to. He wouldn't say. I never figured the manager, the Webster Fur Company, would be the gent who was paying us to get him.  I asked Sorrell a question. I haven't been answered yet. Well, I decided Burley might as well be around when I told you, Mr. Settley. When you told me what? Come on, let's have it. Did you get those furs? No. No?  I would have been as easy as skinning a rabbit. I told you what trail Sasuke you were taking to Mountain City. Well, you could shoot him how to bring a furs to me. Everything sure you did. With some ombre shot again, just as Sasuke will come into sight. Before we had a chance to let fly, he cut back around the bend again. Those shots were a warning? Yeah. Who fired them? I don't know. Did he spot you? No, I don't reckon he even saw us. But there was a blue jay screaming right over our heads. And I guess this jet must have been smart enough to figure blue jays don't chatter just for nothing. Mr. Settley. Well? Me and Burley are mighty dry. Buy your own drinks. Well, that's the way you feel about it. It is? You promised me some ready cash just for taking on this job. Yes, again, Sorrell. I promised you cash for Sasuke's furs. You didn't bring the furs. You don't get cash. I don't pay for failure. Where are you? Don't raise your voice to me, Sorrell.  I'm a respectable man. I can have you thrown into the jail. Settley, one more word out of you. Sorrell. Settley. There's somebody looking in the window. What? I see him. Don't turn around. Don't reach for the guns. I've got one in this drawer. Keep watching me. I'll try to get him. I'll quick out the door. Oh, he's gone. Yeah, he's that horse. Who was it? I don't know. It was an engine. But I never saw him before. I've seen him before. His name is Taddo. His partner is the Lone Ranger. It's all right, Silver-O-Boy. That's Scout. Taddo's coming back to camp. Howdy, Kimosabe. You've been gone almost all night, Taddo. You didn't lose the trail? No. Taddo not lose trail. Now, what did you...  Ah, man, shoot at Taddo. I mean, I hurt bad. Only scratch. From glass, not bullet. Glass? Ah, me look through winter. See bad men. Good. Who were they? Oh, Taddo not know that. But Taddo know other men. There was another man there? Ah, it in back room of Bearcat Cafe. Man who talked to them, shooted me. His name, Sedley. Sedley? The manager of the Webster Ferd Company. I knew it. I was sure of it, Taddo. Never mind now. I'll tell you later. Right now, we're riding. Silver-O-Boy. Where we go? We're going to see John Matlin. He's Marshal of Mountain City. He's going to put those two outlaws in jail, and Sedley too.  Come on, Silver-O-Boy! What's there to say, mister? Are you sure? I don't saw them with Sedley, Matlin. From his description of those two hombres, they sound like Cerell and Burley. Men talk with Sedley. Ah, don't sort of stack up. Sedley's an important man in town. He's kept on the right side of the law. They acted friendly, huh? Ah, too bad you didn't hear what they were saying. That'll be right good evidence. Matlin, there's no time to be late. Sedley and those two outlaws are still at the Bearcat. You're the Marshal. It's your duty to move right now. He know, Marsman. You made me Marshal of this town, and you're the best friend I've got. I'm heading for the Bearcat. Where's Matlin? The town Marshal. He's got his guns. Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Watch out! Those two are known to be bad hombres. I'm an honest man. Yeah? Yes. Why, by capturing these two men for you, I'm doing the law of favor. Sadly, I reckon you're right about these gents. Well, I'm not so sure about you. There's no way I can prove my suspicions. So, for the time being, I'll let it stand. Sir Al, you and Berly start walking. I'm putting you behind bars. Was you? I've admit me and Berly done a few things outside the law. But I tell you, with Sidley, you're asking... Inside the cell! You're making a mistake, Maglint. You'll find that out. I tell you, Sidley asked us to do it. Just believe me. He got in touch with me. Marshall. What the... Who's that? I'll get a light. Never mind the light. You only brought two of them to jail. Who was missing? Who was you, Mass Man? Who was missing?  Only Harry said they couldn't be jail, mister. He was smart enough to disclaim having nothing to do with Berly and Sir Al. Sidley's guilty. Perhaps so, but I can't prove it. Maglint, I know he's guilty, but as soon as I bring you the proof, let's keep an eye on him, until I get back from the little trip. Mass Man, mister, are you hit? The curtain falls on the first act of our Lone Ranger story. Before the next exciting scenes, please permit us to pause for just a few moments. Now to continue our story. When the shot was fired right outside the window of the Marshall's office, a crowd gathered immediately in the dusty street. Can you hear that? Another shot. More doggone shooting going on tonight. It's all right. You know, start drifting now. No more excitement. Are you hurt, Marshal? No, somebody fired through my window, but nobody's hurt. Nobody broke out of jail. I've still got those two hombres behind bars. Who could have fired at you, Madeleine? I don't know. Where were you, Sidley? Me? I was down the street near the cafe. Anybody see you there? I don't reckon so. It's a pretty dark night. You still don't trust me, Madeleine? Forget it, Sidley. Someone in this crowd is a skulking coward. A jant who shoots in the dark.  Sure, that's the way to talk, Madeleine. That's why we elected you, Marshal. You had nothing to do with it. You voted against me. I realize my error now. By the way, you had some company in your office? I thought I heard a horse riding away. Just after the shot. Wait, Sid. You were down at the other end of the main street. I mean, on my way here. Thought I heard the horses I approached. Did you hear it? I heard nothing. I was inside the jailhouse. That's odd. I distinctly heard it. Thought I caught a glimpse of it, too. A big white horse. Missed time. Shot fired at you. Yes, tunnel. Said they missed you early last night. Missed me later. Perhaps he needs more practice with a six-gun. You say, Sidley, shoot at you? Yes, tunnel. You seen? No, tunnel. Marshal and I were inside the house in the dark. The shot came from outside. I'm taking it for granted, it was Sidley.  Bad and clever. Soon as he heard that Marshal asked the bartender for him, he was smart and must to pull out his gun and capture Sorrell and Burley himself. Say that he was innocent. Why you not run from jailhouse? Get him when he shoot. In the middle of town with all the people running that way? Remember, tunnel, I'm wearing a mask. Only Maitland knows who I am. Ah, that's right. Those men all carry guns. It has seen my mask and taken it for granted that I was an outlaw. They started shooting at once. Oh, tunnel, don't think of that. No, the Marshal has to capture Sidley himself. He has to catch him with proof. We've forgotten about those three black fox pelts, tunnel. Huh? Remember, they were stolen from Siskayu's cabin. You mean you trailed people, steel pelts? Is Sidley steel pelts? I tried to follow the tracks, tunnel. But whoever took the skins cut across Bear Rock and Catamount Peak, they lost the trail. Why you say, Sidley steel pelts? I didn't say that, tunnel, it was you. Oh, that's right. Me not savvy. They all mixed up. Right till later, tunnel. First thing to do is head for the trail. Siskayu's waiting in his cabin.  There he is. Come on, Scuddy. Come on, Scuddy. Come on, Scuddy. Morning, Siskayu. Morning, running fawn. Masked men, you left till yesterday evening to find out who take pelts of black fox. What have you found out? Silence, running fawn. It's not proper to ask before we welcome our brothers according to what is correct. White brother, tanto, we have food. You will eat? Not yet, Siskayu. We know you're anxious to learn what's happened, then we can eat. The men who were on the ridge above the trail waiting to shoot you are now in jail. That good. They are ones who steal black fox? I followed that trail from this cabin up over Catamount Peak. The trail disappeared in the rocks. Oh, then you not find... Enough. Our white brother helped us, and he failed. Not matter. Ah, skins of black fox bring plenty cash. Heap cash. Yes, tanto, if they gone, they gone.  I said I lost the trail, but I still think I know who has those skins. You know? With your help I can get them back for you. Siskayu, are you willing to send running fawn into Mountain City to sell the rest of your furs? Speak, white brother. Tell us what to do. It shall be done. What you coming back for this time, Madeleine? Still too early for some reason. I'm letting you skunks out of jail. You know what? Let yourself. You hurt me. Personally, I'd like to keep you under lock and key from now on in. Let's see in this house Siskayu who didn't come into town to provide charges against me. Well, here are your guns. Go ahead, get out. Well, you sure will, Marshal. Leave Mountain City within 24 hours, Heavy.  You sure got out of that mess easy, didn't we, Sorrell? You're so brilliant. We got a score to settle with suddenly first. That home-brain's been acting too slick. If you think he's got me buff-loaded, better think twice. Turn this over to the Lord. So long you've got me, Sorrell. Well, I'll be... Reach for your guns.  We're right out in the street in clear sight of everyone. No major coyote could do what you did last night.  I had to do that, Sorrell. Huh? I knew you'd be released today. I did. Well, of course, and you were. Now, look at it sensibly. My position, I can't afford to go to jail even for a day. How do you understand? Hey, I reckon so. You sure are smart, sadly. Where will you be? I may need you to. We won't be here unless you give us 24 hours to get out of town. No, I did, huh? Well, I may have to make a wagon trip to Portland. Suppose you head that way, camp near the trail about five miles out of here. What for? Kino, sadly. Well, if you're making a trip, why don't you start now? Stop asking so many full questions. Will you be there or not? Yeah. Yes, you and Mr. Saddley. All right, good. I've got some work to do. That's why I'm not leaving it. Besides, I saw Running Fawn going to the great Western Fur Company office with some furs. Running Fawn? Isn't that Siskayu Squaw? Yes, I... I want to talk to her when she comes out. Oh, you, just a minute. You've traded your furs here at great Western? Yes. Why didn't you bring them to the Webster Company? Our prices are good. My husband say take furs to great Western. Oh. Where is Siskayu? I go now. Oh, hold on. The news got around a couple of weeks ago that Siskayu had trapped himself some black fox. Those are mighty valuable pelts. Siskayu, he'd get pelts back very soon. Get the... What do you mean by that? Man who take pelts leave trail. Siskayu will follow. Left a trail, but... You let go. You hurt my arm. How can he follow a trail when... I mean, suppose he loses a trail. Siskayu not lose trail. He take gun. He take scalping knife. Scalping knife. When he find man who steal fox furs, Siskayu get them back. Take care of man his own way. Indian way. I... Excuse me. I just remember something I got to do. Now I go back to Cabin. Tell Lone Ranger I do what he say. Come on, honey. And my soul. Madeleine! Madeleine! Howdy. You been looking for me? Yes. I went into a mountain city, but you left your office. I came out to check on somebody's spring and beaver traps. What's it about? Siskayu had three black fox pelts. They were stolen. Yeah, the great western fire told me about it. The engine squaw was in. So far I haven't got a single solitary idea who could have done it. Unless it was Cyril and Burley. No, Madeleine. They just worked for the thief. You say that like you know who did it. I'm almost certain it was Harry Sedley. Sedley? Siskayu wanted to come along, but I was afraid he'd kill Sedley. That mustn't happen. Now he must go to jail for his crime.  Well, you watch Sedley and then... Listen, it's no you. Sedley left town an hour ago. Left town? What do you mean? Just what I said. Said he had to see Mr. Webster. Oh, Maithund, head back to Mountain City. Round up a pass. Soon start after Sedley. Take the Portland trail. Well, if you say so... I do. Keynoe, mister, that's enough of me. What about you? We're on our way right now. Come on, Tutto. Get him on sale. Look for us later, Maithund. Get him, Sedley! Get him, man. Come on!  Get along now! Right here, Sedley. It's your fight, hurry. You'll find out in just a moment, Sir Elf. See that club is bruised up ahead and near catamount peak? What about it? A rain up just beyond it. I'll stop the wagon. Get up, Burley. It's already more than 20 miles outside of Mountain City. Here we are, right now. Oh, boy! Oh, boy! Oh, boy! Back to here in Mountain City. It's all clear. I don't see anybody. It's a little mystery about Sydney. See that big rock yonder? About 20 feet off the trail? Yeah, it's blind.  Come along. A couple of nights ago, I moved that rock, fastened a rope around it and had the other end on my horse's saddle horn. This time, I reckon the three of us can lift it. What are you getting at? Is there something important under that rock? Suppose we lift it up and find out. Here, Grandpa. Hey! There's something hidden under it. Looks like an old buffalo hide. Unroll a buffalo hide, and you'll see. Here, I'll do it, Burley. Well, I'll be doggone. Black fox. Liam, find a spelt-saver saw it, said Lee. Well? So that's it. These skins belong to Sis Kale. They don't need longer. Now they're mine. Here, mighty Slick Ombre. You stole these while me and Burley was up on that ridge, didn't you? Yes, sir. I always said Jacob Webster was the smartest for a traitor in the Northwest. You're next. I work for him. Jacob Webster likes black fox pelts. They bring a fancy price. If they're not paid for, so much the better. Now, here's where you two fit in. I was waiting for that. When we get to Portland, you'll get 500 cash apiece. Then you disappear.  It's heavy. In other words, you want everyone to think it was us who stole those furries. That's it. Not that they'll ever be traced, but we'd like to be protected just in case. If Jake was me, Mr. Settling. Likewise. Then back to the trail. We ought to reach Portland about a minute. You'll never reach Portland, Mr. Settling. What in? Who said that? I don't see anybody. All right, here. Look out. Up to the... At the top of the ledge. The mask man, the Indian. Here they come! I grabbed your gun. Shoot! Shoot them down! December us! Shoot! Shootin' up ahead! Faster, man! Here's the wagon! Right in the middle of the trail! It's standing idle. There's nobody in it.  They're shootin' stopped. That they mean?  I don't like this.  Now we're talking to the left someplace. Beyond those fir trees. The funny of us here is just riding full tilt. Now follow me! Hold them! If all ropes and tides are stretched out on the ground, nobody else around any place. That wasn't me. It was Settling. Settling stole them firs. They're all alive. All right, Burley. What's that you were saying? I said... Please jump in. Well, Maven. Look at this. Blacks, fox, and pelt. Now those were stolen from Sascale. Isn't that right, Sorrell? Yeah, Marshal. Me and Burley had nothing to do with it. Just get these ropes off now. The ropes will come off when you've got the jail.  How about it? Are you gonna try to deny it? I'm caught dead to rights, Marshal.  I stole them.  Don't beat everything. But hey, I don't savvy. Savvy what, eh? Well, we heard a lot of shootin', and when we get here, these armors are all tied up like packs on a mule. Who did your job for you, Marshal? He knows who got us. Don't you, Madeleine? I reckon I do, Settling. And so do you. It was the Lone Ranger. Oh, you have just heard as a copyrighted feature of the Lone Ranger Incorporated.