Well, good afternoon, everyone, and I have to say it's certainly I want to thank everyone who's organized to get all this large group together. And for someone who has spent about 30 years trying to educate the cardiologists on electrobiology and genetics, it's terrific to see such a wonderful group of people. I think my first lecture said genetics for a clinician was the American Heart Association in 1986 with the Bureau Foundation, and I've probably been doing it a dozen times a year, at least since that time. So it's very wonderful to see so many wonderful organizations here today, and I hope that we will develop something from it to go forward. The other thing that is sort of a vindication for me today, not for what you think, but seeing Gene Passamani, who certainly was instrumental in organizing this, he was my fellow at WashU, and then when he got fed up with me, went off to Washington and told me what to do for the next 25 years and writing grants and everything. I went to Baylor, and one of my favorite fellows was Bill Zogby, who became a cardiologist and he learned to get away from genetics because he used these big machines we all use like echoes. But of course, every night he would go home, and his wife, who you know is one of the world-renowned geneticists, Huda, would tell him about genetics. He'd come to work, I'd try to tell him, but he went off. Finally, both of them have seen the light in the hair today. Thank you. So if nothing else, I might have achieved something. Well, Bill wanted me to say something about the diseases per se in cardiology to illustrate because I think all of us know. Cardiology is a field where you deal with big things and big machines and you do things in a big way, sometimes in a crude way like angioplasty, but that's what it's all about. It's very visual. So to bring in something like a pipette in 1986 was a tough issue. It's still tough, but genetics has moved along, and so I'm just going to say something about few of the diseases that clearly many people in cardiology have made possible, but I will speak about the single gene disorders, the medelian disorders that all of you know, and also say something about the polygenic disorders, although I want to emphasize there's not really a big difference except in the knowledge we have to apply them at this moment, as I think that Dr. Arnett pointed out. Clearly there are estimated about 7,200 Mendelian single gene disorders, and about 3,500 of them today have at least one gene, at least one mutation. And of those, about 252 involve the heart or the blood vessels. So you have a lot to choose from, and as you've heard many times today, where can you find all of that together? The chances are you won't, but it's certainly organizations and meetings like this that could make that possible. Here's a few of them, as you can see, that are associated with sudden cardiac death, and hypertrophic cardiomyopathy is still the most common cause of sudden cardiac death. Now I just want to illustrate here, right now our guidelines would say in cardiology, if you've got a year of medicine and you read the guidelines, you can be a pretty good cardiologist, and you have to stick with those guidelines. But there is more to it than that, and that's the utilization, and that's the problem we come up against. You speak about randomized clinical trials. If we did a randomized clinical trial today, or 20 years ago, nitroglycerin would be wiped off the mat. It will never get through. Never. We did that with dejoxin about 10 years ago. After 100 years, we threw dejoxin out. We don't use it much anymore. So we have lots of things we do that would never satisfy an RCT and never will. So keep that in mind as we go through. But here's a story, depending on how you tweak this, but if you're 12 years old and you've got a history of hypertrophic cardiomyopathy or family, we'll say to the echo guys, echo them every two or three years, at least the next 20 years. You knew you'd do a lot of other tests, not just echoes. Now remind, most of these disorders are out of some dominant. Only half of that family needs to be echoed. So it's not only the anxiety of not knowing if you did the mutation. Certainly, as pointed out by Dr. Nitt, that not all of those mutations, even though they're pathological, will develop a disease. But you can certainly be very cost effective. Every time you do an echo, it isn't just an echo you do. You always do a few blood tests and a few other things with it. So there is both the cost effective as well as improved management for doing mutations in hypertrophic cardiomyopathy. Now it isn't that simple. As I know that Heidi would be the first one to tell you that if you order up a test for HCM, I think it's fair to say somewhere around 60% to 70% will give you a known proven mutation today. What do you do with the other 30%? Now my cardiologist said, oh my god, it's only 70% effective. I just want to remind you that in the emergency room, if you do an ECG, only 7% of ECGs in people with chest pain will change their management. If on the wards ordering chest x-rays or cardiologists, I checked this one out. We did 138,000 in-house chest x-rays on our cardiac patient, the Heart Institute. It changed management in about 7%. So just because it's only 70% effective doesn't mean you shouldn't use it. And so that too is something we have to get rid of. The other point that's come up a lot is, gee, this genetic revolution is complicated. Believe me, I had a choice in the 70s to choose electrophysiology or genetics. I chose genetics. I have only four little things to deal with. It's a hell of a lot easier than reading ECGs or doing electrophysiology. So I would like to make clear today, genetics is very easy compared to most other choices. Particularly echoes one. Now we also look at this, that screening for sudden death in young is a common cause. Arportrophic cardiomyopathy, certainly in North America, is the most common cause of sudden cardiac death below the age of 36 years. After that, of course, coronary artery disease comes in. Look at how good we are at 1% for physical examination. The ECG will show abnormalities. Most of which, of course, is non-specific. You are obligated to look at the story and say, what are we going to improve this? This is the 21st century that tests are available. Now, there are other times when it's diagnostic. For example, the synachronon of hypertrophic cardiomyopathy is hypertrophy, a thickened ventricular wall, either in the septum or in the apex or caseically concentric in about a third of them. But there's another disease called Fabry's disease, which does have a treatment. You can give them an enzyme and treat the disease. Sometimes it's not easy to tell the difference between these two, in which case genetic testing becomes a diagnostic, and sometimes even in other metabolic disorders. Pointing out here that it isn't just from the point of view of genetic counseling or advice, but also for making a diagnosis. A long QT syndrome, which takes up a lot of time in the cardiovascular world in electrophysiology. And here, I just want to illustrate that about 70% to 80% of that syndrome is due to these three channelopathies. But if you have, in terms of the long QT syndrome, due to one of these potassium channels, beta blocker is our preferred therapy.  And that's good enough for most of us. Now, on the other hand, if you have long QT two or three, which is due to a sodium, a potassium channel that's different than the treatment is different. And by a gain, just by experience, beta blockers don't work as well, and mix halitine, flecanide, or ranilocene are the preferred drugs. So here you select a drug on the basis of genetic testing. So from my point of view, looking at single gene disorders, it's clear that there is great value in genetic counseling because it is the most common cause of sudden cardiac death up until age 36. It clearly is diagnostic in some cases, and it has therapeutic implications in diseases such as long QT syndrome. As I indicated to you, it can be very cost effective in a disorder such as HCM. Now, there's no doubt about it. In the sports world, there's a lot of concern about hypertrophic cardiomyopathy, and all of the national, certainly every time I would see a young patient in Houston. In Houston, if you don't want your sons to play football, you got to start at about age three. Otherwise, you've taken religion from them. So bottom line was, we'd always get these people to come and see us. And of course, they're often going on scholarship to college or what have you. And if you happen to have HCM, you've taken everything away from them. So I just want to indicate to you a couple of points. Now, the treatment for hypertrophic cardiomyopathy, really definitive for sudden death, is indwelling defibrillator. At the moment, there are about 6,000 indwelling defibrillators in people with hypertrophic cardiomyopathy. I've told you it's the most common cause of sudden death below the age of 36. When are most of the defibrillators put in? 79% after the age of 45, because they die before they get there.  And obviously, as I've indicated to you, the ECG history and physical is not adequate. All of these people would gladly pay to have that done. Now, you've heard about pharmacogenomics, so Dr. Annette pointed out the problems we face there. But I just want to indicate one thing to you. Because I'm pushed and driven by genetics, we develop a little machine to put on the ward to test for the eight or nine variants that alter clopidogrel. This is a little machine run by the nurse. You take a blood out, rather than use the PCR, we amplify whole genome. You put this test tube in the machine, 45 minutes later, it comes up and tells you whether it's resistant to clopidogrel or not. On the basis of that, this was published in Lancelot a few months ago, we then went ahead and gave them clopidogrel. Now, it's true that 20 or 30% of clopidogrel have those people that can't transform the active form. It's a little bit complicated at the moment because some of those people who are resistant still do very well on clopidogrel. But what I do want to say to you is, clopidogrel cost a few cents. And we got four new drugs. Prazogrel cost a few dollars, each one of them. So you could select your 60 or 70% for a few cents on the basis of this simple test. What most cardiologists do, why bother if it will give everybody Prazogrel? Now, clopidogrel is the best proven test anti-platelet therapy for myocardial infarction for stents and what have you, but still will probably go and pick the most expensive tests rather than going back to doing this. But hopefully the new trials coming out, if they show of course that this is a good way to go, then it will probably creep into it. And I would say, here is the field where you probably do not necessarily want RCT, but you can do work to see outcomes and I think it's appropriate. But back to the other genetic testing. It's a tool to do something with. We've never done a randomized trial to see if biostatisticians do better running them or not because we accept their expertise. I think we have to accept genetic screening in a certain way as a tool and as expertise. We're never going to do an RCT on HCM. It's never going to happen. So here I think it is more appropriate because of the fact that it is testable. I'll now run into the polygenic disorders which are very complicated. And let me say up front, there's nothing in cardiology at the moment that I can say you can use clinically in terms of screening for these diseases that affect coronary artery disease which is our bread and butter as Bill pointed out. But 9P21, I want to point out a couple of things about it. First, when we and the group from Iceland came out and identified this back in 2007, one thing was surprising to us is that 9P21 carries a significant risk. If you are in terms of premature myocardial infarction below the age of 55, it increases your risk a little over two fold. Overall, about 50% if you got two copies or 25% for one copy, it is present in 75% of the population but it is independent of known risk factors. If nothing else, this should say to you, it has been said since 1957 that about 50% of genetic predisposition for coronary artery disease is in your genes. And this is done by epidemiologists, not by cardiologists or geneticists and this is clearly coming out. So if you want to prevent heart disease as all of us do and certainly those of us in the cardiovascular world who feel that it can be in fact prevented mainly in this century, we clearly have to turn to get genetics because 30 to 40 to 50% of it is there somewhere. It's not all in your cholesterol or blood pressure. And I think 1921 clearly indicated to us there are other things going on. Now, we realized very early in the game as I think all of us are realized of being here today, that it would require a large collaborative effort to identify them. And because in fact, they do have a small effect and they're not like single gene disorders. Not any of those are necessary or sufficient to induce the disease. They act in multiples. So the bottom line is we formed with cardiogram, a large group, and this involves both the UK, the US, and Canada. And we put together 194,000 cases and controls and we did obviously, we ran every body sample first with two and a half million of the SNPs. Now we do it with about 18 million SNPs. And so we now have 50 genetic risk factors that have been identified, confirmed in independent groups and clearly all satisfied genome-wide significance, et cetera. 46 of them is in the paper in Nature Genetics we published two weeks ago. The other four just came out, they're mainly in Chinese. So a total of 50 without question. Now, this certainly will make it look more difficult,ologist. And I want to indicate very clearly at this time, it is difficult to know where we'll put this in terms of clinical practice because at the moment, we don't really have a ready place for it. But we have identified, as I'm sure many of you and other diseases have shown, it's no longer like single gene disorders, it's not which gene you have, it's how many of them you have. If you look here, this is done on a population that we have of about 15,000 that we have followed for about four years independent of genetic risk factors, known conventional risk factors, whether it's blood pressure or hypertension or what have you. And so it clearly tells us we must pursue them. I'm sure of those 50, they probably only act in two or three pathways, but we need to know what those pathways are. And I think the time for genetic testing for Mendelian disorders is certainly here now. Even though my colleagues won't always do that, the time has come and it's no longer looking to the future. I think comprehensive prevention will require we do it all the way through. Personalized medicine, it will be difficult to really realize it given the fact that genetics is the basis for it. And having spent 20 or 30 years in the field, I think at this moment, unless we have, everybody here from the different societies agreeing some kind of structured education for my colleagues, I don't think it will do. And neither are we here to teach genetics. You're not going to make them. I think it was well put by Michael when he said, you got one or two hours. We have to embed it into their curriculum. They're not going to spend another year in cardiology. We already have about nine sub-specialties in addition to cardiology. This is the way I think we have to go. Thank you. Great, thank you very much. Okay, so Mark. Yeah, this is for Bob. My understanding is that in Italy, they are actually doing prospective screening for hypertrophic cardiomyopathy and long QT syndromes as a routine part of any pre-participation, physical examination, at least from high school and above. I was curious if they have been generating any outcomes data as to avoidance, identification and avoidance of sudden death. Yes, the data in Italy very much confirms that if you look at the death rate of people who were turned away in high school from participating combatant forces, the death rate is about one third of what it is in those people who were not screened out and continued.  Great. Gene. Another question for Dr. Roberts. It seems to me that there is a tendency among cardiologists to ignore this business and has it stretched to everything?  I once was told by an expert that I was entitled to my own opinion but not my own facts. And what you seem to be saying here is there are facts that very strongly support careful screening. It's very interesting because 9P21, as you know, also accounts for about 26% of attributable risk for aortic aneurysms and also for intracranial aneurysms. We are getting many more requests for 9P21 from the people in stroke and neurology and in the peripheral vascular people than we are from the cardiologists to do HCM. So it's a very interesting story. Now, when I ask them why would you want 9P21 for an aortic aneurysm and not be tuned in for otherwise? It's because they don't know enough about aortic aneurysms, it's the first piece of data they put their hand on. Interesting. We have John Harley. I'm sure among your 50 genes that there's a substantial number with odds ratios of 1.1 and 1.15, the idea that one in nine of the patients that you see or something on that order or one in 10, the gene that you're finding actually contributes. I mean, what would happen is that people are gonna look at the same data and a professional will say this is critically important and other professionals will look at the same data and say, no, we can't use this for clinical application. It just doesn't make the kind of difference that you can rely on to make either therapeutic or diagnostic decisions. I agree with everything you said and you're absolutely correct. And that's why I emphasized in the beginning when talking about this for coronary artery disease, it is clearly early in the game. All I would say to you is that it took from 1954 when cholesterol was shown to be a significant risk factor, then the 72 Brown and Goldstein isolated the gene for the receptor and showed hypercholesterolemia was a disease and the first drug appeared in 1987. Things have speeded up today. We're not gonna take us 50 years to find out how these things are important in finding new drugs. So I would say to all of us, it is on us to try and educate them before these genes find a place. Whatever percentage of them do, some percentage will and new drugs will come out. It's clear there are other pathways other than the ones we know. I'll give you another example. Right now our guidelines, both American Heart, American College, as well as European, Canadian, Cardiovascular, all say if you have a cholesterol or LDL, a 160, and you don't have any other genetic risk factors, not that. But if you have one other risk factor, such as hypertension or smoking, then we should lower it to at least 140. If you got two, we'll go down to 120. And then with more than that, the disease will go to 100. Right now, 9P21 is being concerned to be present in 4.5 billion people. It's an independent risk factor. Everyone across the continent has practically shown that.  Everyone will look at me and say, you're crazy. But if I said you got hypertension, which is just as unrelated, yes, you can drop it down to 140. That's the kind of reasoning I think we have to prepare them to get out of in the near future. Excellent point. We have, I think Bill Powell had a comment and then, oh, you didn't, I'm sorry. Oh, okay. Yes, please, Wolfgang. Yeah, these polygenic models with rare variants, they're all by necessity additive because we cannot test just what you said with the two risk factors that are more than additive. And they really don't add up, even with 50 genes and rare variants, you don't add up to more than 15% increased risk. So I think what we need to try to find out how to look at the dynamics of the interactions among this, which is right now statistically very difficult because you don't have the numbers, even with 200,000 people. So there are still other factors there that we haven't looked at at all outside the rare variants. Yes, I agree entirely. And I think many of those who don't reach 10 to the minus eight, and there's about 180,000 in this group that don't, and certainly many of those are, and you're right, we add them together, but they probably interact in a much more collective way in the body, and so we're stuck with that situation. But be rest assured, ordering up a test for a chip that's got 100,000 genes are just as simple as ordering up for your electrolytes. Excellent point. Bill, did you wanna make a comment? No, I mean, ultimately we have to put it in a patient context. And we have limited resources at this stage of the game. It has to bring value to our value equation of taking care of patients. So yes, we did not go for the sake of time through all the educational things that the college does, but it is along the line of most of the other professional organizations that we need to engage in that equation. And at this stage of the game from Bob's point of view, one is the single Mendelian-like genetic disorders. This is really a must nowadays to be able to do this. And I think we have to communicate that to our physicians, our total health care team to be able to do this. The polygenic ones are still big areas of research and hopefully down the line it will be cost effective and also changes our management down the line, Bob, with all the data that is coming forth. So I think it's very exciting, a lot of area of research. Jeff. I think I just wanted to make the comment that I think it's great to communicate about Mendelian disorders, but I think most of the cardiology practicing community will need something a little bit more, the clinical decision support tools and understanding how to access the tests and some of the interpretive services. So I think that's a great start, but I think to really get it to effective use in the clinic, it's gonna require more along those lines. And we talked about that. I think the college is embarking on a big digital strategy to have at the point of care the tools for the physicians. So whatever we communicate should be available at the point of care through their smartphones or pads or whatever it is available for them to be able to at least to help them going through this decision process. Great, I'm reminded that we have at least 65 if not more live stream watchers and I don't know that we have a mechanism for them to ask questions. So do we know if we have a mechanism? I'll ask my colleagues in the back. We do. There's a live chat running on the first one. Okay, so if live streamers who are listening want to ask questions, how do they do that? Can I wonder if they can hear you? Probably not. I was just trying to be like, Mark. So if there are live streamers that are out there that want to ask questions, go ahead and sign into the chat and put your questions in and I'll forward them to Terry. Or I could speak them for you. That would be fine too. Okay. That'd be great. Super, thank you. All right, thank you very much, Bill and Robert. That was terrific. We really appreciate it.


Now I'm out of the toffee TV. This is the Sunday supplement myself Paul Nealon You might recognize me from the channel before I don't know a lot of Sunday supplements But obviously the corona words put a halt to that because games are coming so thick and fast But for the season, I'll be doing them here. So make sure you check them out every Sunday Going forward throughout the course of the season. All right, so we'll get straight in obviously everton have won today I wouldn't ill win Against spurs in their stadium, which is the first time in a long long time last time We did that Yalovic scored the winner. We've got two goals late on peanut and Yalovic But here we are who are after breaking that horrible record The top six Record away from home. We've broken that today on the cattle and she lotty might as well get in talk about the team line up because No, people weren't sure what's hammers gonna play was the decor a gonna play was Alan gonna play and they all played So I suppose we get in we talk about the line up and we're gonna go about from there So, you know, you had Pickford and go which I think everybody knew was gonna happen You'd call my right back, which I thought was the right call defensively is the best right full Then you've got me and keen thought we've done really well I wasn't really shocked by the month and look at Dean on the left end I wasn't shocked by him obviously being in there He's first choice and you know, we need to keep him fit for the for the whole season because he's just such a Crucial player for us then in midfield. You had Alan Alan whatever you want to call it sitting in front of the back four in that midfield tree and he had decorate and you're on Andre Gomez Then further up the pitch you had hammers cutting in from the right-hand side and Richard on the left and Dominic Avalon Through the middle which kind of alternated throughout the game But I said when I seen the line up, I was like, this is ambitious from Angelotti. He wants to make a statement here I wasn't sure whether the players were gonna be ready or not and Ultimately they showed that obviously they were ready and more than ready even because they went out and they put on an unbelievable performance I'm starting off the game. We like we were you know, go in possession kept it tight We didn't really give them anything. You know, I thought we were brilliant Knocking the ball around everywhere on the pitch And we just look solid as Alan was coming in putting out for us everywhere And that was only the first few minutes and the only real chance of note I can really remember that was a big one was obviously when Ben Davis hits that ball back to Aldervoral and Richard just takes off like a thunderbolt and gets in rounds the keeper Just steady yourself just take a touch and he blazes at what wide and over on On his left foot and if he just takes a touch there just steadies himself He's so much more time than he realized and he can just square back to Dominic Avalon Or in you know, in other ways you could have looked at it He could have taken the first time on his right foot rather than round the keeper But look, I think obviously with Richard Allison a couple games in I think he'll be scoring regularly again He's just so crucial to the way we play and gets gets us up the pitch and such a tref for them like every team we play fears him and They there's a reason why they kick lumps out for the whole game to try and keep him quiet He's a tough little bastard and that's what you need and Alan as well as a total bastard too but and I just thought I just thought they We just start so well and they couldn't believe that how professional and disciplined we were It's just a shadow of the team that we played, you know, two months ago They let us play then after what we started dictating the game They had a couple of chances pick for it made some two really good saves And I don't really give pick for too much credit that often both today. I thought he was brilliant I thought this was the best game he's had in a long long time And this could be the turning curve that you need now this season a fresh season get over the hump from last year Because he's never really been the same keeper since that or Regi mom, which we won't get into anyway but I feel as though he needs now a fresh kind of Fresh kind of approach now. He's got the good players around him now He's got that protection as well Alan in there But I just felt as though to a man everyone was brilliant today And I felt as though we had more and more chances as a hammers as well. I haven't even mentioned yet And just flashes of brilliance. You can just tell when he gets used to the swing of the Premier League He's gonna be scoring and producing, you know, great moments for us And I think he's going to be such an integral part. We obviously still need to buy more players I'm not happy with just the recruitment we have but the three midfielders that he's brought in or you can class Hamas as a white as a winger now, but Just the energy in the midfield and Alan just looks so much better than Ghana like in terms of he gets the ball He gives it he doesn't have a heavy first touch when he gets the ball that Ghana used to do with Ghana It was brilliant to just break and play but Alan has just he actually gets the ball and gives it out simple And he can pick out past to there was times where he was whipping balls Out to the wings and stuff like that that never looked like they were on He looks like a fabulous player and one that went under the radar Now, maybe I might be getting carried away after one game, but we will see how that how that kind of plays out But today was brilliant to Corey energy everywhere brilliant Andre Gomez bit of a mixed bag and obviously cigarettes and coming on for him, but I mean You look at for Charleston and hammers and Dom and Dom's goal I mean that ball whipped in by Leucadine and Dom's head out all my days That was delish. That was that was unbelievable It was Duncan Ferguson esque and it was just something we've been crying out for Dom to get the girls back amongst them You know since since lockdown and it didn't go his way Unfortunately, you know, hopefully this is just the thing he needs now to just get more room for the season He's got the goal out of the way. He has a little bit of leeway now, but he led the line brilliantly I thought he made Aldo warrior look Archer for a lot of the game. I thought this is the best I've seen Dom playing a long time He's obviously been working hard on his fitness because he looked way We looked much fitter as well than they did which usually on first days of season We are always the slower team. I remember we played Spurs a few years ago on the Cuman first game of season And they just looked so much more fitter than us and everything like that And I was just we I wish we were there. Well, I think we've caught up with them now We've obviously beaten them. I don't think we're headed them in terms of their progression, but I think We're on our way to climbing back to where we need to be After all the misspending and stuff like that, but just to go back to the goal. I mean If any other top striker scored that you'd be gone. Wow. What a header the way he just bullets in from the angle that he was at And the ball in as well. Look at Dean. He's just yeah, he's just always you just know That he'll turn up and he'll he he'll keep getting the balls into the box He'll keep providing those good assists and and just always creating chances You know, I think he's blessed a little bit now because he has other players that allow him to do more But she must calm very good defensively When he has to do anything regarding their winger, he was always solid throughout And I think he was very solid at the back and we already mean it as well I top pick for as well coming out for balls Coming out and punching it a few times when we needed them to because you know a lot of times He lets the defenders deal with the crosses from to come and do that And then at the end when he came to collect the cross, you know It looks like he has a confidence back and if you can build on that then hopefully, you know And the substance that came on he had tickets and brought on and Moise King came on just to kind of run down the clock a little bit at the end I kind of felt a little bit sorry for him, but don't never really deserve to come off I would have kept them on but then look It's a fantastic win. It's a win at their stadium now and it's been a long time I think with five managers since we last won there So that just goes to show how hard it is to win there and we've gone there. We've got the result and we've We've set up our standards for the season now I think I go back to the game when we played Man United when Fellain he scored first game of the season And that set us up for the season then we set a marker and that's the standard now for the season I believe we play Salford now on Wednesday. It's on score as well. So Being just to see what you know, will you play reserve players? Will you play players like Bernard or Woby these types of lads? Or will he play the full strength team because then we play West Brom then after that so Look, it's it's definitely positive. I Can't remember last time. I've done one of these and I've been so positive and happy and watching everything I'm just like, oh, this is brilliant to see and other people giving us credit all all all knowing You just be see people giving us credit and it's not You know making us a laugh and stock, which is normally the case We always just do some stupid that makes us look really really silly But now, you know, Carlo looks like he's got the recruitment that he wants And now we need to build on that and hopefully it's not the the last of the players to come in before the end of the transfer window I still think we need to to add players in certain positions, you know, right wing being A big place where we I know James was playing there but I'd rather see him maybe in the number 10 and then alternate between Gomez and Decorey And yeah, I just think there's players there that could really learn a lot from the players around them And I'm really excited to see where this team can go now So let me know your thoughts in the comments if you want more videos from me. Check out Irish football fan tv I'm sure to leave a link in the description. Don't forget to subscribe to toffy tv, of course And uh, don't forget to join them on patreon as well. I'll speak these all soon. Thanks for watching guys


Welcome back everyone, we are in Acts chapter 1, we will continue from the same passage. Alright, so we said that in this passage we have the ascension of the Lord Jesus being spoken of by Luke. He makes it very clear that you know Jesus is now ascended up into heaven. He talks a little bit about the ministry of Jesus. He talks about the Trinity. He talks about the empowering work of the Holy Spirit even in the life of Jesus. Why is it so? Simply because the Lord Jesus was fully man and we know that. We know that he also needed the power of the Holy Spirit in order to move in signs, wonders and miracles. That's a very encouraging thought because we all have the same Holy Spirit in our lives to help us. We see how Jesus spent 40 days continuing to do his wondrous works among people. As 1st Corinthians chapter 15 reminds us there were at least 500 people. Many people which is about 500 people who witnessed him and who saw this resurrected Jesus. So it's a historical event, 40 days after when we know that the Lord Jesus when he was taken into trial and he died. It was the Passover and many rituals of the Passover activities of the Passover are talked about during the death of Jesus Christ. So 40 days after the Passover Jesus was around with the people and we saw how the focus of God doesn't change. The message doesn't change. So even when Jesus was resurrected and ministering to the same disciples, he stuck to the message pertaining to the kingdom of God. And that is a reminder for us. We must not move away from the core theme of the Gospel. We must not move away from the Lord Jesus being our central message. We should not move away from preaching about the demonstration of the Gospel and all the essentials that so far have become the foundation of what we believe. We must continue to speak the same things and that's what Jesus said. He talked about the things pertaining to the kingdom of God. Now let's move ahead to verse 4 here. And we see how these disciples were during the resurrection of Jesus and meaning at the time when Jesus was with them before the ascension. So in verse 4 it says, and we assemble together with them. He commanded them not to depart from Jerusalem. So what's happening now? Jesus is not ascended. He's going to ascend and Luke is saying that Jesus was with the resurrected Christ was with the disciples. He gave them a command. What was the command? He said, don't go from Jerusalem but to wait for the promise of the Father which he said, You have heard from me for John truly baptized with water but you shall be baptized with the Holy Spirit not many days from now. So Jesus talked about the kingdom of God. Now Jesus is also talking about something else that is important. And we are going away on a long vacation or a long break or some assignment where we are going to leave behind the people that we work with or the people at home. What do we do? We give them the most important instructions. So first he spoke about the kingdom of God and now he's talking about the Holy Spirit because he knows that the Holy Spirit is so important for each believer. So he's commanding them. He tells them, look something special is going to happen in Jerusalem and I don't want you to miss it. So he says wait. Wait means what? Wait until you receive. Wait till it comes to pass. Okay. So you need to receive it. You can't miss it. And that's the point here when he says you wait in Jerusalem till you receive what is in store for you. And he's referring to this upcoming event or what the people are going to receive as the promise of the Father. So what is the promise of the Father? The promise of the Father is the baptism in the Holy Spirit. If you go back to Matthew chapter three, even then John the Baptist seems to know about this promise where he says, Oh, look at this. We all the Lamb of God. This is Jesus. I baptize you with water, but you know, he will baptize you with Holy Spirit and fire. So even John the Baptist knew about it. We know about the prophecy of Joel with the children of Israel would have been aware about and Jesus is actually talking about that. And he's calling it the promise of the Father. He's saying the Holy Spirit will come. You will be baptized in the Holy Spirit. So it's really beautiful because just in these verses, verse four, verse five, you see the Trinity. Why? Because I'm being assembled together with them. He commanded. He is who? The Lord Jesus. He talks about the promise of the Father. So the son, the father, and then later on, but you shall be baptized with the Holy Spirit. Not many days from now. So we can find all three personalities and just these two verses and how beautifully they work together. So the promise of the Father. When we use the term promise, what do we expect? That has got to be a fulfillment. There is a promise, but there has got to be a fulfillment. So that was the special command of Jesus to the disciples. Look, something beautiful is going to happen. The promise that people waited upon all along is going to be fulfilled. The Holy Spirit will come and he will baptize it. So this is what he says, wait for the promise of the Father, which he said, you have heard from me. Jesus had already talked about this to the disciples for John truly baptized with water, but you shall be baptized with the Holy Spirit. Not many days from now. Also, let us recall that Jesus is talking to people who have already received the Holy Spirit as believers. You go back to John chapter 20, you will see, you know, over there you will see that Jesus is resurrected and he's ministering to the disciples. So at one point he breathes upon the disciples. What is breathing upon? It is the release of the Holy Spirit upon the disciples. So we as believers, when we believe in Jesus Christ, what happens? The Holy Spirit comes to dwell within us at that point itself. So where the disciples born again? Yes, we can say that they were born again because of the breathing of Jesus upon them and the Holy Spirit already went and began to dwell in them. So now what is Jesus doing? Jesus is talking about a different experience. They're already believers. They're already born again, the disciples. But he's saying, I want you to get something more. What is that? He says baptism, baptized with the Holy Spirit, not many days from now. So baptized, we talked about this in other courses, you know, baptism. When we look at that Greek word, it's the term immersion. So the way John baptized, how did John baptized? John baptized people unto repentance in water. So they were completely immersed in water and they came out of the water. Signifying now their new journey with the Lord, their renewed heart. Now in the same manner, Jesus is saying there's a separate experience of being baptized in the Holy Spirit or being immersed in the Holy Spirit which I want you all to have. So totally, Jerusalem would wait for the promise of the Father. Very exciting. Wait for the promise of the Father. John baptized with water, but now you will be baptized in the Holy Spirit, not many days from now. And Jesus also reminds them, I've already spoken about this to you and I really want you to get it. And over here, another reminder for us is that at this time when the disciples had not yet received the baptism in the Holy Spirit, only once you see Jesus telling them, wait. Nowhere else as we continue to read the book of Acts, you will notice nowhere else will you find the apostles or the believers telling other believers you have to wait for five days or 10 days or something like that to receive the Holy Spirit. There's no waiting component later on. In fact, in some instances, it's like they go, they lay hands, they pray and people are baptized. So they never tell people to wait for the baptism in the Holy Spirit. That waiting is only in this first chapter where Jesus told the disciples to wait in Jerusalem because it was going to happen in Jerusalem. So let's clarify that because there are teachings where people tell people you have like, you know, teachers of the word tell believers you have to wait. You have to wait for many days or just wait upon the Lord and you will get the, you actually don't need to wait. That was an instruction given to the disciples by the resurrected Christ. Let's move on. If you have any questions or any point, please feel free to just talk to me and ask me. So we will try to delve deep into the truth that we can get from what we are reading. So verse six here says, Therefore, when they had come together, they asked him, saying, Lord, will you at this time restore the kingdom to Israel? So, you know, the disciples are just being themselves. They know these are special moments. They know that Jesus is instructing them like this because he will go away and he won't be with them any longer. And they're asking irrelevant questions. They're so excited. They're like, we need to find out from Jesus about these crucial things. Why did he come? He came to die for the sins of the world. We saw him dying. So looks like the restoration of Israel is going to take place. So notice how they are disconnected to what God wants to unfold the way God wants to do things. Their questions are not even connecting to what God is wanting to do at that point in time. So they ask a disconnected question. They say, Lord, will you at this time restore the kingdom of Israel? Now the promise was there in Scripture that Israel would be restored. So it's nothing out of what Jesus had spoken that they were asking him. But the timing was not correct. They could have asked him many other questions. But at this point, they ended up asking him about the restoration of Israel. But that was not the immediate plan of God. So how did Jesus respond to their query? Verse 7, and he said to them, it is not for you to know times or seasons which the father has put in his own authority. So he's saying valid question, but you know what? Just leave it to God regarding these times and seasons. You don't have to focus on this particular matter. He brings back their focus. He says, you know what? I will tell you what is important for you. It comes back to the point of the Holy Spirit. So just think about this as believers, the Holy Spirit is so important for us. That is what Jesus talked about repeatedly. He said, wait, don't miss it. You will be baptized in the Holy Spirit. I've already told you about it. And then he's saying, don't ask those questions because the Holy Spirit will be poured out upon you. That is what you should be focusing on. He comes back to the Holy Spirit verse 8. He says, but you shall receive power when the Holy Spirit has come upon you. And you shall be witnesses to me in Jerusalem and in Judea and Samaria and to the ends of the earth. So Jesus is reminding the disciples, you need a different focus and that focus should be the baptism in the Holy Spirit. And he's explaining it to them. He's saying the Holy Spirit, when the Holy Spirit has come upon you. Remember, I said that they were already born again. So a born again believer, do they have the Holy Spirit in them? Yes, every born again believer, we already have the Holy Spirit in us. And the Holy Spirit does his work of leading us, of reminding us of Jesus, giving us the conviction about sin, righteousness and judgment. So he continues to do his work. But there is another special experience with the Holy Spirit that Jesus is explaining as, when the Holy Spirit has come upon you. The Holy Spirit coming upon the believers is the baptism in the Holy Spirit. So Holy Spirit is already inside. But another experience of the Holy Spirit coming upon us is also crucial for the believer. What will happen to the believer when they are baptized in the Holy Spirit? He says, you shall be witnesses to me. Are these people not witnesses right now? They continue to follow Jesus, isn't it? Yes, we know that the disciples were distracted. When Jesus went through his trial, Peter denied Christ. They were not, if you want to say it like the best disciples that Jesus could have expected. Yet they were witnesses for Jesus. Yet they were known as the disciples of Jesus. People associated them with Jesus Christ. But now Jesus is talking about another level of witnessing. You shall be my witnesses. You shall be witnesses to me. When you look at the word witness there, the Greek word is matus. Out of which we get the word matus. So it's almost like Jesus is saying, the kind of witness that you are going to be, that you will see the baptism in the Holy Spirit is, you will be like sold out. Not that all of us are going to be martyred, that's not the point. But it's that commitment. That level of commitment to Jesus, the level of the work of God in our lives and our love for God, which will be birthed in our hearts, it's going to be at another level. So you shall be my witnesses in Jerusalem, Judea, Samaria, and to be end of the earth. So he is saying, you are going to be a special witness for me, greatly committed to me. You will see the power of God being demonstrated through your life and everybody is going to know about it. So how does he tell the disciples that everyone is going to know about it? By saying, you'll be my witness here and everywhere. So he is using that progressive way of speaking. Geographically, we know Jerusalem, Judea, Samaria, and to the end of the earth. So everyone will know that you belong to me and you are my witness.  And that is the reminder of the Lord Jesus. So notice two things that Jesus laid emphasis on and that Luke is pointing us to. He's saying, he talked about the things pertaining to the kingdom of God and then he speaks about the baptism in the Holy Spirit because as believers, the disciples needed it. As believers, we needed it. And these are the two things that Jesus had spoken of before he ascended. Now going to verse 9 here. It says, now when he had spoken these things while they watched, he was taken up and a cloud received him out of their sight. And while they looked steadfastly toward heaven, as he went up the whole, two men stood by them in white apparel who also said, Men of Galilee, why do you stand gazing up into heaven? This same Jesus who was taken up from you into heaven will so come in like manner as you saw him going to heaven. Now, people have a question. What was the need for Luke to say that they watched him and he was taken up into heaven? He could have just said Jesus ascended and left it there. But there are explanations to why Luke may have said things like this. So, some commentaries say that after Jesus resurrected, people were talking, they were kind of making their own stories about Jesus. And once Jesus ascended, they could have been so many stories without sufficient proof, isn't it? So, Luke is making it very clear. He's saying, look, Jesus didn't escape to another nation or escape to another region. Let's make it very clear. All the disciples witnessed while they watched, he was taken up and a cloud received him out of their sight. So, he makes it very clear where did Jesus go? He ascended up into heaven. And a cloud received him. When we talk about the second coming of the Lord Jesus, we see that he's coming on the clouds. He's coming back on the clouds. So, it's like saying, he went into heaven and he come back from heaven to receive us. And Luke is making that very, very clear. He's also saying, they looked steadfastly toward heaven. Meaning, let's not have any confusion about this. They were watching as he was taken up. That is the real story here that Jesus ascended up into heaven as he went up and they were just watching the Lord Jesus. Now, we can imagine the emotions that the disciples could have been through. Oh, Jesus, you were with us. It was so good. Bread was multiplied. Wine was water turned into wine. Life was so beautiful with you, Jesus. And unfortunately, they saw the trial of Jesus. Jesus died on the cross and they must have been in anguish and grief at that point. But wow, once again, God does this wonder of resurrecting the Lord Jesus. And Jesus is back with them. The disciples would not have wanted to meet Jesus. If they had an opportunity, they would have held on to Jesus and said, don't go anywhere. We want you right here. Okay? But in front of their eyes, he's ascending up into heaven. So when Luke is telling, they looked steadfastly toward heaven. You can only imagine all the emotions that went through them and they're thinking, why is this happening?  What are we going to do? Maybe some of them would have been worried. How is life going to be? How will we be his witnesses? What is it that we have to do? But many questions and, you know, grief and I don't know if joy would have been a part of this list, but they were lost. They were only looking at Jesus and they were thinking, what do we do now? They looked steadfastly toward heaven as he went up. You see, we are in positions where we are wondering, Lord, what do we do now? How do we go about our lives now? God is faithful to give us the essentials or, you know, the keys, whatever we need at that point. He already told them, look, you know what you need? We need the baptism in the Holy Spirit. Get it, okay? Don't forget it, forget it. You need to be grounded in the truth and be focused on that. Now, he is sending a reminder in the form of two men stood by them in white apparel. Now, the explanation about these men seems like they could have been angels. So, when we need an angel or when we need, you know, God to speak in a certain way to guide us, God is so faithful, he does it. So, there were two men in white apparel, most likely angels who stood by them and they told them kind of gallery. Why do you stand gazing up into heaven? Or in other words, they are saying, don't worry, this is not the end of the story. There is so much more to come. There's so, you know, like an exciting life ahead of you. Why are you standing gazing up into heaven as if everything is over? It's not over yet. And they are reminding the disciples, you know, there's Jesus who you saw being taken up in the cloud. This same Jesus, they are also clarifying to the believers. He's going to come back. This same Jesus who was taken up from you into heaven will so come in like manner as you saw him go into heaven. And you know, Paul talks about this. He talks about this. He talks about, you know, the resurrection of the believer in the book of Corinthians. He talks about the second coming of Christ to the Thessalonians. So he says, we are people of hope. We will be resurrected. If we die in Christ, we will be resurrected and the same Jesus will come back to receive us. So these angels are giving them a message of hope and they are saying that Jesus will come back in the same way to receive you. But what is the other message that comes through to us over here?  You've got work to do.  It was so nice sitting and listening to sermons. It was so good being in church. Yeah, good. We've received what we need to receive. Whatever God wanted to impart it to us, we've taken it. But there's work for us to do now. So it's like God telling them, come on, now it's your turn. You've got to go. You've got to do your work and I'm getting you ready for it. I'm going to baptize you in the Holy Spirit, your disciples and you will do that work. So that's why we say the Acts, right? So earlier we said the Acts of the Holy Spirit through God's people. But the Acts of the Apostles is, you know, what this book is titled the Acts that the Apostles did by the power of the Holy Spirit. So till now it was about what Jesus taught, what Jesus did. Now it's got to be about what the disciples, the Apostles are doing. But who is who is the one empowering them to do all these things? The Holy Spirit. But there is a work for every disciple to do. And that was the reminder from these angels. They said, come on stop casing at heaven how you get up. You need to go. You need to get a work done. Okay, now let's come to verse verse 12 here. Let me quickly pause just to see if there's, you know, anything that we want to talk about. So yeah, okay, Jeffina is asking a question here. Is there any reason why Jerusalem, Judea and Samaria were mentioned? I can only tell you what I think Jerusalem, Judea and Samaria. So those were the regions where ministry would happen through the Apostles and God knew that. Primarily those are the regions and then Paul and his team would go a little further. So though it says the end of the year Europe, Asia Minor, only that much they could cover in their lifetime. So God was just saying what is going to happen. But it is also like pictorial language where God is saying that the place where you are and the place a little farther away from you and the farthest places you will impact. So it's literal and pictorial. Yeah, thanks Jeffina for that question. Anything else? What are you all thinking as we are talking about this? Are you feeling excited? Is that a no? I can't hear any one of you saying anything or commenting. Okay, only Subash is excited and happy. I feel encouraged. Okay, Jeffina is also excited. That's great. Okay, everyone you know, this is an exciting book of the Bible where, yeah, thank you Lyndon, where we are seeing how God started to work you know through His people. So right now we've seen the ascension of Jesus and we've also seen the encouragement or the redirecting of God to the focus that the disciples need to have.  Let's go on to verse 12. There it says then they return to Jerusalem from the mount called Olivet which is near Jerusalem, a sabbathay's journey. So they come from, they come to Jerusalem because that was the instruction of Jesus, right? We commanded them you stay in Jerusalem. So what have they done? Obedience they obey Jesus. He told us to be there. We will be there. They go to Jerusalem and it talks about how long the journey was and when they had entered they went up into the upper room. What is this upper room? It is said that the upper room is you know a place near the temple. It was a place near the temple. Now we are aware that the festival of Pentecost is around the corner and that's the time when people choose from many parts of the region would come to celebrate the Pentecost in Jerusalem. So you know places would be offered rented out and all of that and so it was common practice. They could actually come and they could get a place for themselves and be there. So upper room is one of those spaces where the disciples chose to stay. So they went to the upper room or this particular place where they were stayed. Now who are all part of that group in the upper room they elisted out Peter, James, John, Andrew, Philip, Thomas, Bartholomew, Matthew, James the son of Alpheus, Simon the zealot, Judas the son of James. They noticed 11 disciples have been mentioned. But isn't it supposed to be 12? What happened? Okay, so Jeff and I are saying later on we will see Matthias joining, no? Yeah, but who is supposed to be in this group? Judas is carrying. Correct, correct. Yeah, Rosalind. Judas is carrying. So he is the person who is missing right now. And that's why, you know, I said only 11 are here. But what is the beauty about these people? They all continued with one accord. Right?  So Judas is carrying it backslided. He went away from Jesus. But these 11 disciples, what is their story? They continued with Jesus and that's a beautiful reminder for us. Yes, when we begin our journey with Jesus, it's wonderful. And all these dreams are in our hearts and we have a vision and we have passion. But keeping that passion alive and journey with God till the end, that is required of us. We are being reminded through the lives of the disciples that here are 11 men who continued, they continued and that in this specific situation, they continued in one accord it says meaning one heart. What is one accord? One accord is having unity of heart. Now, physically we can be together. We all know that even if let's say three people are in our home and they are physically together they can be so different in their thinking their values and what their purpose is and there can be a lot of how do you say strain in the relationship of these three people. But here you find that these 11 men are continuing in one accord meaning they are together in heart regarding the purpose of God and at this point, what is it that they are believing God for? Together they are believing God for the promise of the Father. Jesus said not many days from now you will receive it. So they believe that and they are together and they're all trusting God. Yes, it's going to happen. You know maybe pray, it says prayer and supplication. So that again is wonderful knowing that the disciples knew what to do with what Jesus had spoken. Jesus said all these things. Now what do they, what is the first thing they are doing about what they have learned? They are praying, they are speaking to God earnestly, supplication and they say Lord, you said all these things, please do it in our lives. So prayer, a life of prayer in unity with one another they are seeking the Lord. So that attitude of seeking the Lord is part of the disciples and that's really beautiful to see how they are living for God and they were not alone because we see that there were women with the disciples so obviously the ministry of Jesus it impacted many lives. There were 12 disciples of Jesus but there were many other followers they were 12 apostles but then there were many other disciples of Jesus. So obviously these women also were followers of the teachings of Jesus and that is why they were also there waiting for the promise of the Father you see that Mary the mother of Jesus she was also a disciple of the Lord Jesus. This is something for us to note as the mother of Jesus she could have been like okay whatever God wanted to accomplish through my life I've done it it's over now let me just live my life however to Mary was she also continued she knew who this Jesus was the Son of God himself and so she's looking at him in that light isn't it not just as a son but she is giving him the honor of the Son of God so Mary is also part of that group and with his brothers now that is really beautiful I don't want to get into the details of that but we know there are passages that say that the brothers of Jesus did not give him honor as the Son of God they treated him just as an ordinary person alright but at this point we notice that we notice that even the brothers of Jesus have put their trust in him so James Jude these are all the brothers of Jesus and they have become the disciples of the Lord Jesus and that is exciting news for us so how did they become disciples you see some people point to the resurrection that the resurrection was such an event that it jolted people out of their unbelief to know that oh this person Jesus the carpenter's son we know him we know his family but it's when he died and he rose again that especially the family of Jesus realized it was not an ordinary human being but it was the Lord himself who came and lived among us so even the brothers of Jesus put his trust in Jesus so it's so beautiful that you have the apostles you have other disciples you have some women you also have the family of Jesus who are there in the upper room what are they doing they are waiting for the promise of the Father how are they waiting they are waiting in prayer and supplication and it says in those days Peter stood up in the midst of the disciples nothing new about Peter he loved to talk he loved to be the first one you know and in some commentaries we read about Peter and his personality which is said that he spoke before he thought I don't know I hope Peter is not angry with me for saying all these things but you know some people evaluate him like that before he understood what he was saying and at times when he needed to step up you know at the trial of Jesus he wasn't covered us like he didn't show up he denied Christ he fled the scene and that's really sad even at this point the disciples are in a crucial time and something has changed in the life of Peter yes like he always does he speaks but the note is that he's taking leadership he's taking his position of leadership how did it happen well it was the way God has called each of the disciples the way God has called each of us and the grace which was upon Peter's life nobody had to tell him Peter this is the time you need to address the disciples because they may be in doubt they may be in grief Jesus has left us he's ascended into heaven nobody had to tell him anything but the grace of God which was upon his life Peter stood up he automatically took the position of a leader and amazing to see that everyone else is following along we're actually listening to him so it was the way God worked that was the time for Peter to take like the wheel in his hand and begin to direct the disciples on what needs to be done he stood up amidst the disciples and we are told that number of names was about 120 so when we imagine the upper room it must have been a big room because there were 120 people there and he said to them men and brethren the scripture had to be fulfilled so now Peter is beginning to lead the disciples he's addressing them and how is he ministering to them on the basis of scripture so he feels like something important needs to be done right now on the basis of what scripture has spoken so what is it that will be done now he says look as per what scripture said which the Holy Spirit spoke before by the mouth of David concerning Judas who became a guide to those who arrested Jesus so he's talking about Jesus he's talking about Judas and what happened to Judas the fact that he betrayed Jesus and then you know Judas hung himself very like a very unfortunate death a very gory scene that he paints out over here he fell and he died and all of that but he reminds the disciples that according to the word of God this has happened so he quotes a passage here from Psalms he says let his dwelling place be desolate and let no one live in it let another take his office so he's just reminding the people that all this has happened but scriptures do mention that we have to position someone else in that place to that Judas Judas left, wake it so Peter is taking responsibility to bring in another leader into the fold of the apostles okay so now are there any questions are there any doubts about Judas I've been asked this question in the past session so that's why I just thought you two might be wondering you know when Peter says that the scriptures are telling us that somebody has to take his position it almost feels like the scriptures had predicted that Judas is going to do this and that he will betray Jesus so is it like God you know people use the term allowed God allowed or God designed for Judas to sin against God and then the position would be vacated you know Peter and all would have to go and do an election for the 12th person in their group so it's not like that so we must understand that free will is something that is so important to God if you go back to the garden of Eden God created man and woman and he told them you can have everything but you don't eat of this certain tree God never controlled them he gave them the option he gave them free choice and said it's up to you I'm telling you what needs to be done but you make your choice so in the integrity of this thought when we talk about the life of Judas I'm sure God would have spoken to his heart many times and he would have had the opportunity to make the right choice but for whatever reason he went ahead and made the wrong choice but God knows the end from the beginning isn't it it's not that God is directing somebody's God is controlling somebody's choice but God knew what Judas is going to choose and thus there is a mention in the book of Psalms that this place is empty let his habitation be desolate or when one sings against God that dwelling place of that person is desolate and let no one live in it let another take his office so it's pointing to Judas in a manner that God in his full knowledge was aware about what is going to take place it's not so much that God controlled the life of Judas and you know Judas was made to sin to have the story that we have today so we must not look at it that way because God is the initiator of free will and choice and so it was Judas's choice to betray Jesus and do all the things that he did very very unfortunate to do that so we see that Peter was actually asking for the disciples to pick another person so that's what happens from verse 21 therefore of these men who have accompanied us all the time that the Lord Jesus went in and out among us beginning from the baptism of John to that day then he was taken up from us one of these must become a witness with us of his resurrection so he's wanting an apostle in the team and again we'll see how they chose they are choosing a faithful person because what does he say he says among those who have been with us who have from the beginning baptism of John so it's not like these people suddenly came into the picture those who have journeyed faithfully with Jesus and us among them let us pick someone so they propose two names and they say Joseph Corbassavis and Matthias come on among these two let us pick someone and it's beautiful because even when we had to select among two choices it was not so much a mental exercise but it was a prayerful exercise to us 24 we read and they prayed and said they pray to God and they say God reveal your purpose to us you or Lord would know the hearts of all show which of these two you have chosen to take part in this ministry and a apostleship from which Judas by transgression fell that he might go to his own place and they cast their lots and the lot fell on Matthias he was numbered to be 11 apostles so though it seems like only election you vote let's vote let's pick the right person but it was a prayerful selection of the person according to the plan according to the purpose of God so this is from Acts chapter 1 just an introduction for us but we will keep getting deeper into what's happening in the lives of these disciples I really look forward to seeing you in the next session which is about the baptism in the Holy Spirit so let's pray and close if there are questions please continue to post it on the stream page I can address them request somebody to please pray we close we come to you under the name of Jesus we thank you for this Dave we thank you for this time of class that we had we thank you for taking up the cross we thank you for this direction and ascending into heaven again so that we can have this great Holy Spirit so that we can receive the baptism of the Holy Spirit so that we can be filled with power filled with your guidance and do mighty things for your health, health, Jesus your plans your works or your own imagination thank you for everything that you did and God be blessed this class as we listen to the next classes help us to have a deeper revelation of who you are and what you have did for us we give you all the glory and honor in Jesus name amen thank you Jafina thank you everyone God bless you have a good day we meet again in the next class bye for now


Hey everyone, mo'kong bakit sa isang counter side video. So today, we're going to talk about Shadow Palace 2 floors. Sorry, rooms 1-5. But before that, if you would have updated counter side videos, please hit the subscribe button down below.  So, I'm going to just go back and see where it is. So, I'm here right now. I'm going to resume this one. And I'm going to be featuring a couple of lineups from room 1-5, which is room 5, is the boss room. And these lineups are going to be flexible enough that I'm going to recommend a couple of builds for you. Okay, so we'll start off with room 1. Okay guys, we are here at Shadow Palace 2. This is going to be your room 1. So, as your defenders are going to be bad for this one. So, Alex here will be your main tank. And for this stage, Estorosa will be the boss. Okay, so I'm going to be bringing in Alex and Cindy as my main strikers. Options are going to be Einstein's way for this one. For my rangers, I'm going to bring in Kyle Wong. Option will be admin rifleman or Xin Zhao. Support is going to be Sigma here and Claudia. Okay, and also Yang Harim. Bratom supports for this one. You can actually bring Evelyn for this one if you don't have Claudia. Then for my snipers, I have Edel and I have Yudmila. As you've noticed in what you call this in my Shadow Palace 1, most of the units that I brought there, I'm going to bring here. So, the trend is I'm going to limit your unit count for use for Shadow Palace. You don't have to level up multiple heroes. So, I'll use more or less the same heroes or majority of the heroes that I used in the past Shadow Palaces and with this one. So, this actually rounds out your room one. So, this team is actually built for autoplay as well. And for your operators, it doesn't really have a big, what do you call this, big play. But what I'm bringing is Sigma and the ship that I'm bringing is going to be Enterprise. So, let's check this out for my autoplay. Okay, so we start off with, of course, Sigma, Alex, and a sniper on top. Alex can actually handle this. Then you have here Claudia to support healing. So, there you go. So, the next I think that came out, okay. So, Lyudmila is going to use her ultimate then. Also, Sigma. Just in time to support facing Estarosa. Again, Claudia is going to be healing and the rest of the gang are actually in. So, that is how you more or less hold off Estarosa. Estarosa is actually going to be relentless. So, healers are going to play a big part in this one. So, the initial surge of Estarosa you have to handle that with Sigma, with your healer, and more or less, try to hold her off at the start of this round. Okay, so I'm actually going to clear this before a minute 30. Okay, so a little bit tough when you're facing her ship which is like superior. Actually, I forgot the name. So, anyway, that is a clear. And we're going to go next to our room number two. Okay guys, so next is going to be room number two and let us prepare for this one. Okay guys, so here we are with the team that I'm going to bring for room two. So, for this room, Boss here is going to be Claudia and she's going to affect a certain area of the ground. So, that is why it would best for you to bring majority of flying units here. So, I have here Rosaria, Lissu Yun, and Janus. You can actually opt to take out Lissu Yun here. You could probably put in other rangers, but again, flyers are the best for this stage. So, for this team, I'm obviously going to bring strikers, sorry, I forgot to mention that snipers will be banned from this stage. So, as you can see, I don't have any snipers. So, Cindy and Alex, I'm going to bring for strikers. So, option is going to be eyes this way again. For your rangers, I'm bringing Rosaria. As you can see here, Janus is here. Kyle Wong is here. And also, you can sub in Shinja for Kyle Wong. Then, for your support, you have Claudia here for healing and Young Harim here. And you could also bring Lissu Yun so that you can decrease the healing of Claudia. And Evelyn, you can swap out for Claudia, sorry. That is it. So, more or less against snipers will be banned. So, let's see how this plays out in autoplay. Okay, so, start off with Alex and Rosaria. Then, you have Lissu Yun. So, again, we're going to take advantage of air superiority here. So, the goal is for Alex to hold onto the front line. So, again, she is healed by Claudia in the nick of time. And again, hopefully we can take out the evil Claudia on the other side. So, Janus is here for a reinforcement as we keep on moving that line with evil Claudia. Then, Young Harim is here. Next is going to be Kyle Wong. So, Janus turns into a defender because he's been damaged. But again, we're trying to push back Claudia here and take her out. So, again, this is going to be good. But this is going to take a while, guys. So, Alex is back. Then, Kyle is going for his ultimate. Next is going to be Janus to be coming back. So, again, this is going to be a hard stage because Claudia here is going to be healing. So, again, once you take her out, legs of your ship won't be that much of a challenge. So, again, we're clearing this just below 1 minute and 30. So, again, guys, that is how you clear the stage. Majority of your rangers will be air units. So, let's move on to room number 3. Okay. Okay, guys. So, here is my lineup for room 3. So, this stage is going to be a ban on strikers. And the boss here is going to be Shinja. So, you'll have to take advantage of your snipers to take her out. So, I'm bringing in for my defenders going to be Lee Yu Mi. So, you can actually bring in admin shield man or stronghold for this one. My rangers were going to be Cal Wong, admin rifle man, and Shinja. So, again, you can slot in Kim So Bin if you don't have anyone else. Support. I have here Young Harim and Claudia. You can actually bring in Evelyn for this one. And for my snipers, again, I have here Lyudmila and I have here Edel. So, you obviously can bring in Shaolin or Sylvia for this one. Preferably Shaolin because of the damage. So, Sylvia will, I think, will have to sit this one out. So, let's check this out on auto, guys. Okay. Again, the boss here is going to be Shinja, the evil Shinja. So, you have here Lee Yu Mi. Then, you have Young Harim. Then, Edel is up. Then, you have here Lyudmila as your sniper. Then, just trying to hold this off so that we can heal. And there you go. So, basically, we're off. So, just have to, again, have another go at this. Well, that was quick, Shinja's down and more or less we are near the ship for Lake Superior. So, again, the key here is going to be your snipers, guys. They're going to deal a lot of damage. So, again, Shaolin is actually perfect for this one as well, but I'd like to use Lyudmila because she's a new unit that just dropped. So, again, just bear with me. I'm just showcasing what she can do in Shadow Palace and why she is very good here. So, as you can see here, I think I can clear this in 1 minute 30. So, again, there you go. Cleared in 1 minute 34. So, that is a win for room number three. Okay, guys. Okay, so let's move on to room number four. So, I'm going to prepare for this battle. Okay, guys. So, here's my lineup for room number four. So, the boss here is going to be Claudia and Shinja. They're evil twins. So, for this stage, it's a max deployment of 25. So, obviously, I've gotten it down to 25. So, obviously, what do you call this? Your awakened units are discouraged here. Probably in the first three rooms, you can actually bring them. But, for here, it's going to be a max of 25. So, that is the limitation for this room. So, let's take a look at this. Alex is going to be here for your strikers. Then, Cindy. Eyes is the way, again, is going to be your sub if you want. Then, Kyle Wong for my rangers is going to bring. Shinja is going to be your sub if you don't have Kyle Wong and also your rifleman. Young Harim and Claudia are going to be here. Evelyn is actually a good sub for Claudia. Then, you have your snipers. I have three of them. You have Edel, you have Yudmila, and you have Sylvia here to round out your team. So, this team is Specialized Sniper. So, let's take a look at how I can clear this in auto. Again, your tank here will be Alex. So, for those who haven't gotten Alex yet, she's going to be really good in Shadow Palace. Her banner is still up. So, why don't you guys get her? Because again, you won't regret getting her for your teams in Shadow Palace. She is a very good tank for a striker. And again, she will really, really give you easy wins in Shadow Palace. As you can see, I'm still pushing up to the ship. So, you have Shinja and we have Claudia here. So, we're going to have to be tactical about this one. And again, air units are going to be better for this stage. So, as you can see, I'm still pushing because it's quite a bit a difficult stage to handle. So, Yung Harim with her ultimate, then you have Sylvia with her ultimate. So, try to push again for this. This is actually taking a little bit longer. Again, it's really hard to push with those two. Defending their ship. So, going to have Lyudmila out again for my, what do you call this? My aerial sniper. She was killed a while back. Then you have Cindy to be out. So, hopefully, this is actually the final push that I have. So, I have almost all of them here. Again, the key here is going to be Edel. You're going to, you know, Kalwong is also going to be key here. And this clear is actually that long. So, okay, we're actually half of Lyxapyr. And I think I'll just be clearing this stage just below a minute. So, again, that was actually a long push. So, we're near the end and that is it. So, it's a win. So, again, this is actually your room number four. Obviously, each rooms actually are going to be harder than the previous one. So, this is going to be hard. And my best time previously was 139. I'm down to 12. It's okay as long as we clear this one. So, next is going to be the last boss room, which is room number five. So, let me prepare for this and let me show your, okay, guys. So, for room number five, so the boss room, this stage is going to be a comeback for Esther Rosa and the restriction for this one is going to be soldiers and a max of 25 deployment. So, let me just tinker it down. Have to swap in Claudia to be able to bring it down to 25. So, this is actually to my team below 25. And as you can see, guys, I'm just going to go through my team. So, Cindy and Alex, again, are my mainstays here. So, Isis Way can actually be the sub for them. Kyle Wong is actually one of my rangers here and you can sub in Shinja or Rifleman if you don't have Kyle Wong. Then, for your support, you have Young Harim again and Young Harim and Claudia here for healing. Snipers, you're going to have to bring three again. So, you have Edel, you have Lyudmila, you have Sylvia, and that is it. So, almost identical to your boss for room. So, let's take a look at this team. In action for your autoplay. Okay, so, this is going to be kind of the same in terms of lineup for boss number four. But again, the boss here is going to be Esther Rosa. So, we're a bit different. You're going to have to do some pushbacks here. That is why Claudia is here to do healing on Alex. And most of the bosses are going to be here. So, you're going to have Shinja as well. You're going to have late. I think you're going to have Claudia as well here. Again, this is going to be a big push, guys. Hopefully, I could do this in the first push, though. I don't exceed this in two minutes. So, again, you have there. Claudia already raking havoc. Then enters Kyle Wong into the picture. Okay, so, we're in the ship. Just a little bit more pressure. Young Harim with her ultimate. And you also have Lyudmila with her ultimate. So, the reason why I actually kind of was slow in the past room because Lyudmila was actually taken out and she had to respawn again. But this one, easy, easy win at 144. So, there you go, guys. So, that's a clear for your room number five for your Shadow Palace 2. As you can see, cleared. Then, after this one, I'm going to give you guys also the clears for Shadow Palace 3. So, why don't you look forward to that? And that is it, guys. Anyway, for those who have stuck this far in this video, please consider subscribing. Also, don't forget to click that bell icon so you don't miss any counter side videos. Also, put in a like as well. And take care, guys. Stay safe. This is The Warden and I'm out of here.


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All right, thanks very much. Thanks for having me This should be an interesting day. I mean I was watching the demo. It's pretty mind-boggling This is the kind of stuff that five years ago you would have said no no no This is Star Trek right kind of looks like this. So who has ever seen a live futurist before anybody has yeah Okay, most people only know what a futurist is so I will start with this. What does a futurist do? And a lot of people are actually experiencing when I speak you know I've done about 1,600 talks in the last 12 years and I see this a lot kind of a future shock You may know the book by Alvin Toffler or This I'm Fascinating and you know that Spock Lend on Neymar died a few weeks ago. So fascinating as a word. I use for the unexpected Fascinating Fascinating Fascinating while you get the point a lot of my a lot of my work is fascinating But it's also quite scary sometimes when you're looking at the future saying wow all these things are happening That look like Blade Runner like minority report But keep one thing in mind when we talk about artificial intelligence and big data right? This is not Hollywood Hollywood makes movies so that we're entertained that you know artificial intelligence will not take over our lives in ten years, right? There are some dangers and we'll talk about that, but basically what we have now is pretty Amazing fascinating and sometimes scary exponential change and this is interesting You know when I started on the internet 1995 Doing something like Spotify. We were right in the beginning of this curve And it didn't matter if you would double from zero point zero point zero to you know on from there But today we're actually here. We're at the takeoff point of an exponential wave of technology And that has lots of challenges and lots of really amazing things that we see happening here at this takeoff point We're going to see stuff that is for example the idea of how long computers will have to Advance to fill have the same capacity than the human brain. This is a great graph You know for illustration purposes same thing as here not much happened in the beginning But then we have this right very quick growth in just 10 15 years All of a sudden were records were called to singularity, which is an interesting thought that the machines could be as intelligent as at least with numbers And not emotionally hopefully Then then humans, but definitely a change that we're going to see in the very near future Everything that can be digitized and automated will be music films television books money Yesterday Facebook money and today was announced Everything that can't be digitized automated will be mind-boggling change and basically what's happening technology and humanity Or overlapping Now I see this primarily as a positive thing I mean, it's an interesting angle when you're looking at this You know it could be all kinds of dystopian stuff that we see out of this including The the possible reign of robots, right? But basically we have to think about technology also in an ethical way This is probably I would add that to the tagline a new way to work a new way to think about values That will be also be important But when we look at this curve one more time, we go back to what this company. What would they call? I think something with an end Nokia Used to say connecting people Now it's used to be about connecting things the Internet of Things, but tomorrow is about connecting intelligence That's a whole different cup of tea So we're talking about stuff like this, you know, we've seen this around for years cloud computing and data You've seen of course the possibility of tracking and looking at people and reading what they do You look at basically looking inside of people with nanotechnology and nanobots and all the stuff That was you send out genetic engineering and of course the future of robotics and artificial intelligence And all of that is going to be about connecting intelligence This rather convoluted slide is from a friend of mine Frank Diana. It shows one thing really important And we'll make this available for downloading later is that these trends are combinatorial not just exponential So you're looking at all these things together connected healthcare sharing economy autonomous vehicles. It's all happening at the same time It's not happening one after the other. So if you think about this combinatorial exponential interdependent It's a pretty mind-boggling future the next 10 years will hope flas and probably of course after that as well Very important to recognize about computing. We used to use computers for system of records keeping stuff keeping information Then a few years ago social media so-called About systems of engagement. That's what we see here, right and then about systems of intelligence And that's a really different way of looking at an order of magnitude larger what we're doing here It's a lot larger to think about intelligence and engagement than to think about records So if you have data and that's just records, it's kind of useless right is dumb data garbage in garbage out, right? Can't do much with it, but intelligence. That's a whole different cup of tea Hemingway has a great saying How does a man go broke? Gradually then suddenly and I can't tell you how many of my clients have experienced this Because five years ago. We're looking at this and we're saying yes. It's totally obvious what's gonna happen, right? Facebook and all the social media companies and what's happened. They will do money, right? If you're a bank It's obvious today it happened and the banks are crying.  That's right here between the linear and the exponential So digital transformation of pretty much every industry again started with music film television books You know, most people are now that are getting a little bit Not exactly to be 25 or 30, but older are looking to read on the kind of life because you can zoom and you have a light right Digital transformation of books three times as many Kindle books sold as printed books in a very short time And we're talking about this right a reset of the mind How we work how we interact how we communicate and of course, what kind of values do we have? I mean, it's clearly going to be very important discussion here and we're no longer thinking about industries It's a very interesting example. It's a great book called the end of competitive advantage It's not my book. There's still a good book. It is basically like this, right? The industries are converging to be an arena I mean if you're looking at IBM is a great example, right? IBM is now playing an arena of things It's no longer what boxes hardware or software. It's a whole arena of things That happens to all of us now Every day we're thinking about what else you take the example of Tesla my favorite example Tesla is not in the car business. What business Tesla in? mobility transportation data I Mean they're connecting data they're finding data on what people do and they're going to sell their data And they're going to get into businesses that have nothing to do with four wheels That's arena thinking we have to think about arenas great example here About arenas think about the self-driving car, right? When we look at the self-driving car You know if you actually drive isn't this not going to happen in the way that we think in 20 years You know driving a car is extremely complicated for humans, but driving a car in a separate lane in the city We're going to see very quickly. Here's a short little video clip from a Dutch insurance company It shows what happens when you don't have the right context and timing Introducing the all-new self-driving car it does the driving for you so you can catch up on the more important things in life It automatically takes the right turns Effortlessly avoids unexpected obstacles Well you get the point you can see the rest on YouTube, but you know if the context isn't right for what we're doing It it's a misfit It has to fit in with the other stuff with society with other things great example is television Transformation happen in television. It's no longer this I mean if your 20-year-old kid moves out he's not going to have this he's gonna have this right the cloud Television is in the cloud now. It's any screen any anywhere in the world if a movie studio This is not going to look very good for you because in the past you sold a DVD for 25 years Now you're selling hulu or Netflix for $10 a month for a hundred thousand movies That's called disruption So I have a question for you for your businesses is some of what you do Digitally contestable can come somebody come up and take a piece of what you do by inventing something around it That's a key question Airbnb Just robbed hotels came into the back door Facebook today the banks and Those competitors are not from your sector, but from your arena very important to remember Gary Hamel said the biggest reason the companies fail is that over invest in what is as opposed to what might be This is a key point, especially in Germany right speed over perfection. I would never say that in Germany, of course This whole idea of saying okay, we have to think about what might be what they use imagination I mean why is 95% of of internet Entrepreneurship and and new innovation coming from Silicon Valley right because they have imagination more than pretty much anything else We have to think about what might be All right, I'm of course I can execute as well But imagination is not really a sort of a cultural trade of where I live in Switzerland, right? It's more like a version But we have to think about what happens here now is that artificial intelligence is part of all of these things And it's mind-blowing the stuff that we see here Now look at this is a software that the Facebook founder Mark Zuckerberg invested in called vicarious And he says we're building software that things and learns like a human Think about that for a second I mean that's a sort of overlap of human machine and the interfaces. We're seeing every day now speak into your computer Gesturing you're not going to type in the words that we just typed in here earlier. You just speak And it will be interactively presented you'll have wearables that will do that for you There's good things and bad things about that You know, I would never have an Apple watch myself because I'm already distracted enough as you can tell And but computers are no longer that other thing outside of us This is a very big shift in society. We have to think about that means for example for sensor networks the internet of things Technology becomes invisible and kind of moves inside of us and look at this You know, this is actually very fitting to the topic here at mainframe desktop computer laptop tablet mobile head I could be having a hell in America. They say that there's a very good word for this a term You know how called hell then right as hell and heaven both depending on how you look at it But you know predictive analytics clearly will become a default predictive not not in the sense of predicting like, you know, five years from now But getting a good sentiment and using solid data to do that. I mean clearly we're going to see a lot of this not this but This is an interesting slide that points in the right direction Because while we have prediction models and we can do that week, we will not have omniscience. I Mean ignorance is dangerous, but omniscience looking for omniscience is even more dangerous It's very important to remember that we have to have those insides, but omniscience is not what we're talking about here There is another part to that equation So if we go on this direction, we're clearly seeing this mind-boggling warp speed takeoff going back to Spock, right? He's inside of this and many people talk about this being sort of a VUCA world volatile uncertain complex ambiguous, you know, it's a military term so you can expect death to follow But we have another kind of VUCA that we're seeing all around us velocity unorthodoxy Richard Branson is like the embodiment of unorthodoxy Collaboration I mean actually what's called hyper collaboration and good old American word awesomeness Well, we say well, this is really a mind-boggling. This is awesome I once you folks up and once you start watching Netflix over the top and you cannot just do it in Switzerland But you know using an I be a tunnel right then you can watch the whole thing you say well This is awesome, man. This is what I've always wanted or Spotify Look what's happening here in terms of awesome how many companies have reached a billion dollar valuation the time has been crunched completely So I'll give you a short summary and then I'm I'm looking for your questions by our Twitter and then personally if you're some client point number one the future is exponential and combinatorial and It's gradually then suddenly so if you're wondering how quick this will take it is usually very gradual and then all at once It's very important to remember when you look at your client Invest more in what might be You should spend 5% of your time thinking of what might be then you're really going to be ready for the future Deploy systems of engagement and intelligence and I don't just mean software internally. I mean in terms of thinking This is not about records about data. This is about engagement and intelligence and the new VUCA is the flip velocity unorthodoxy Collaboration and I have finished with that awesomeness. Thanks very much for listening