The Clinical and Translational Science Awards, CTSA, Consortium, comprised of approximately 60 National Institutes of Health, ME, funded CTSA hubs at academic healthcare institutions nationwide, has been tasked with improving the Clinical and Translational Research Enterprise. In collaboration with the NIH's National Centre for Advancing Translational Sciences, NCATS, the Consortium implemented common metrics and a shared performance improvement framework. Initial implementation across hubs was assessed using both quantitative and qualitative methods over a 19-month period. The primary outcome was implementation of three common metrics and the performance improvement framework. Challenges and facilitators were also elicited. Among 59 hubs with data, all began implementing common metrics, but only about one-third had completed all activities for three metrics within the study period. The vast majority of hubs competed metric results and undertook activities to understand performance. Differences in completion appeared in developing and carrying out performance improvement plans. Seven key factors affected progress, hub size and resources, hub prior experience with performance management, alignment of local context with needs of the common metrics implementation, hub. This article was authored by Lisa C. Welsh and Roda Timoia Coticell, Farsat Nuburi and others. We are article.tv, links in the description below.


Here, I would like to quickly give an introduction of the positive psychology, how it is understood mostly in the current times and then we will move on to the cultural nuances and how role of yoga has emerged and eventually became part of this course. So, here I would like to mention about Abraham Maslow, Seligman and Chikandmi High's work. Abraham Maslow obviously was much before the Seligman and Chikandmi High's work. Abraham Maslow is mentioned here because he was the very renowned psychologist who did his writings in the 50s and 60s. Most of you must be familiar to his need hierarchy theory but many of you may not also be familiar that he was the person who first time in a very articulate ways talked about holism, meta needs and the self actualizing tendency of human being. All these are very positive in nature. He talked about holistic perspective of looking at psychology. He critiqued the atomistic functional view of the world and he claimed that he want that psychology should not suffer from it and called for not only developing holistic perspective but also developing research methods which can understand the whole the human being in its holistic nature. And holistic means it cannot be reduced in response, it cannot be reduced to simple few tendencies which someone has acquired in the childhood and looking at human being as a dynamic constantly evolving entity. He talked about the meta needs which is beyond the basic needs which need not be satisfied. He talked about self actualization and in order to fulfill the meta needs in self actualization human beings can forego even the lower level needs. These all things were appeared in Abraham Maslow's writing. But probably it was not carried out in a very empirical way at least in the famous American psychologist paper of 2001, Salishman and Chikandmi Hai point out that and they say that Abraham Maslow and other psychologists who are termed as humanistic psychologists their work at number one it became much more self centric and number two not much empirical inquiry was carried out to take forward that work. Whatever may be the reason Salishman and his colleague were able to articulate the positive psychology in a very emphatic way. See positive psychology the aim of positive psychology is claimed by the leaders of the field as achieving flourishing and flourishing is understood to be in terms of an acronym Parma that that stands for positive emotions, engagement, relationships, meaning in life and accomplishment. So, positive psychology is a study of flourishing naturally the well-being is reflection of flourishing but it is not only personal well-being it is relationship as well as meaning in life as well. It also aims at studying the conditions to flourish conditions and processes that contribute to flourishing and optimal functioning of people groups and institutions. So, here you see evolving from the humanistic psychology positive psychology not only focuses on people it also focuses on flourishing groups and thriving communities evolving institutions naturally as the emergence of the field itself is result of this process this is not and this is very different from treating illness. It is based on the fundamental insights that treating mental illness is not same thing as promoting mental health it is very solution focused it is not merely corrective and limited to offering solution only when things go downhill but it is telling people what should be the attitude what activities they can carry out what interventions can be done to not only attain flourishing but also retaining flourishing. In the recent review they have identified 51 types of 51 different interventions systematically studied in the positive psychology. So, when this special issue of American psychologist about positive psychology appeared it attracted major reactions lot of positive reactions almost everybody welcomed this move of a field of psychology to study the things of life which makes it worth living looking at the potential of human being looking at the possibilities of the human nature all that was widely appreciated it was also critiqued on being very ethnocentric. So, there are large number of scholars who pointed out this this aspect and Christopher and Hicken bottom have captured the essence of many scholars who have mentioned about the ethnocentric perspective not being inclusive nature of the positive psychology field as was reflected in that particular issue in that is special issue where 15 articles on different aspects of the positive psychology was published. So, what Christopher and Hicken bottom write that current efforts in positive psychology are deconstructed to reveal an adherence to the dominant western conception of self and its accompanying vision of the good life as personal fulfillment. So, they pointed out that there are many cultures which can have different notion of self which is very different from the notion of self held by the liberal or neoliberal society of the western world. Essentially they questioned that positive psychology cannot be universal or the way it is presented cannot be universal because of three things. Number one vision of world is different in different cultures what is the vision of world that is we are going to look at in the second in the next slide. Notion of self is itself is different which is arise which arises from the worldview or vision of the world notion of self what is self that itself is different that that understanding itself is different in different cultures. As a result of that the very conception of happiness and what makes good life also differs. So, how can there be a universal positive psychology or if at all there is a need and there can be a universal positive psychology we need to do more thorough job we need to have more cultural perspectives we need to have examining the basic assumptions of the current formulations of positive psychology more thoroughly using cultural lenses to make it more inclusive so that it can become more generalizable or if I may use this word more universal. So, first thing we look at the worldview this notion of Christopher and Hicken bottom is based on the work of Charles Taylor. Charles Taylor in 1989 wrote a very interesting piece on modernity and emergence of self and he talks about two types of worldview prevalent in the world what is worldview? World view is basic assumptions believe values about how this world is and how it works. So, Taylor's point out that different cultures have different worldview and they can be merged and they can be summarized in the in a one in a term called one-tire worldview or single-tire worldview and two-tire worldview. One-tire worldview suggests that world is what is visible human being is what is visible what is experience what is empirical what is objectively verifiable and the happiness and responsibility of the life is particularly is solely lying in the individual inner situation. It is on the individual where the responsibility of his or her happiness lies that is the one-tire worldview, but two-tire worldview which was prescribed by most of the cultures particularly before modernization and so-called enlightenment in the 16th, 17th century it talks about two-world views it talks about two-world two-tire worldview Greeks Balinese and Indians these the these three example can point out this aspect Greek they used to believe in having a life of necessity which is the necessary biological survival situation that is one world and there is another world the world of called us and which is good life which is life of citizens beyond necessities life of the citizen which makes society worth living that makes the essential human nature of the humanity these cultures are talking about more objective reality which is more based on biological survival or at max social needs and also a transcendental aspect of the world these cultures also believe and many culture is still hold that beliefs hold that belief that it is the transcendental reality which imbue the value in meaning to the mundane so-called mundane reality so Balinese and Bali is greatly influenced by Indian culture as well they talk about Sekala and Niskala Sekala is again is a reflection of the ordinary realm of everyday life experiences and Niskala is the spiritual world that is deeper level of reality that is invisible to the untrained but ultimately determines what occurs in daily life and what is sadhana sadhana is the process of unraveling that what Balinese called Niskala and Indians called para vidya Indians say para vidya and opera vidya para vidya refers to the higher learning para is beyond opera is which is not beyond which is immediately accessible through our senses so para refers to higher learning learning related to self or ultimate truth that is transcendental knowledge so here the self is used and professor eschage actually used it beautifully he wrote that a small self with a small s and self with capital s self with a small s is born by our identity about our physicality about our social circle and governed by individual ego whereas self with the capital s is the real self where nature all the creatures and the whole cosmos is included realizing that thing realizing that inherent oneness what is called non duality underneath diverse form of nature knowledge of that is called para vidya that governs the so called mundane life which is perceptible through our senses and this culture believed that what is life is much beyond my sense perceptions but studying that also is important because we have to do the agriculture we have to set up temples we have to construct things people have to build their family society has to have norms there has to be exchange of things business has to be developed so apara vidya is also important but that apara vidya is in a very tentative way we are calling it lower knowledge it is not considered lower in indian tradition but it is suddenly not considered ultimate it is not considered that about which rishi of upanishad says that knowing which nothing else is left to be known there is a story in the upanishad where a child comes where a boy comes after receiving education from his guru he comes back to see his father and father was working in a garden and just by while working in the garden he looked at his son he asked okay so have your education is completed he said yes and then father asked but have you got something have you come to so he says that boy we are brahmins by definition brahmins means those who know the brahman those who know the ultimate reality those who have the access to para vidya so we are brahmins and we are supposed to have the knowledge of brahman and that is what is the ultimate knowledge so have you known something that after knowing which nothing left is to be known that aspect of para vidya is the ultimate realization of human potential that is why it is called self realization but that self realization has as as capital because that is the real self brahman is the real self atman is jivatman is but a sense of self which is result of the result of the sense of separation arising from ignorance this aspect of the world view what charles taylor calls two-tier world view is present was present has been present in most of the cultures before modernization but what is the world view being prescribed in the existing literature of positive psychology that is reflected in the form of definition of self basic assumption of self is reflected in their work so positive psychology is currently largely based on dominant western and particularly american ideologies and christopher and king bottom write that it is clear that it is based on cartesian distinction what is cartesian distinction that that is the thought given by that great scientist that subject to a world and object to a world are different realm of sciences to deal with the objective world objective reality anything which is not in the objective reality anything which is not objectively very fable is not the matter of science so it is not the matter of knowledge it can be a matter of belief notion of fixed and essential self is also evident in the writings of positive psychology thirdly it talks about meaning and values are subjective in nature and person should be free to determine both the meaning of and means to pursue the good life and christopher and king bottom point out different questionnaires different psychometric assessment tools to study well-being to study even flourishing and then this suggests they point out that though these questionnaires are having element of other orientation if they have the element of inclusion so called others but what gives meaning to life is largely understood to be understood to be the choice of human being there is no great meaning as such universally it is human being and depends dependent on his tendency or her tendency to find something meaningful or not so the means to pursue the good life or happiness in whatever manner they choose that is the basic assumption and they should choose as long as and they can choose anything as long as that do not interfere with the ability of others to do the same


On your computers also is the brief so you can click along since some details that may be able to be a better flesh here at the CPX here at the division for at the division main down to the DSC down to an actual launcher and at the end of the year once we have tested this capability right now still lighted our eyes here folks obviously not sweet so our voice communications we can remote into our office and as he talks about it take that with you as we sort of test these things one of the ways we get around that


I did science at school primarily, and I went to university initially to study chemistry as an undergrad. So I went through in the UK what's called the ordinary degree chemistry programme, so not into honours. Then I switched into biochemistry because I just found biochemistry more triggered my interest in the sense, I'd always been a bit interested in biology, although I hardly studied biology at school only in first year. But I was really interested to understand how this chemistry was actually applied to living systems. It takes a big leap of faith to understand that what goes on in cells is not really magic. It's chemical reactions going on in there, and I wanted to know a little bit more about how that worked. So background and organic chemistry helps, but it just gets you into the subject. I was really lucky actually in my final year as an undergrad in Bristol. I had some great teachers who, I don't want to sound too high for looting, but really inspired me to get involved in the area I've been in ever since. There was one guy in particular, this was the time when we were just starting to understand how hormones like insulin work. It had all been a complete black box, nobody had any idea how it worked. They did things, they made your cells take up glucose from the blood and store it as a molecule called glycogen. But nobody had the faintest idea how this works. We were just starting to get the first inklings of what the mechanisms might be inside the cell that allowed a hormone in the bloodstream to change things within the cell. And this guy just got over to me that, not that this was a fantastic story that was all cut and dried, but they were kind of on the real tip of an iceberg that there was beginning discoveries that were going to open up a lot more research in the future, not just to find out how insulin work to control sugar metabolism, but how cells as a whole worked. And luckily I was on to the, made the right hunch. It's been true the last 25 years have been a voyage of real discovery in that area, because that's also what underlies diseases like cancer. The principles are the same, the details are different, but once you start to know how these things work in principle, you can then start to ask questions about what happens in this disease or in that.


Listen to Herbert Marshall as the man called X. Wherever there is mystery, adventure, intrigue, in all the strange and dangerous places of the world, there you will find the man called X. The time is shortly after midnight. Somewhere in the U.S. zone of Germany, an army transport plane is taken off from a secret airbase and withdraws wide open as roaring through the moonless night, roaring toward the east, toward Gekko, Slovakia, and the Iron Curtain. And you can't do it.  Maybe. What else can you call parachuting into Gekko, Slovakia, trying to work your way into the Jochimov uranium mines? Look, Chief, Johann Werner is an old friend. A report from Prague says he's been sentenced to slave labor in those mines. I ain't gonna try and get him out. I know how you feel about Werner, but can you too valuable a man to throw your life away like this? No man's life is as valuable as freedom. Johann Werner is one of the leaders of the Czech underground, one of the men who's trying to keep freedom alive. Sure he is, but they... Pilot's warning signal? Yeah. Yes, we're... over the farthest outside of Kámsbár. You want to reconsider? Sorry. See you, Chief. So long. Three of the latest glorious pronouncements from Moscow. Sonius. Three of the news. Sonius. A copy of the Kámsbár Zeitung piece. Yeah, I'm in here. It's a title. Thanks. Here. Dankeschön, ma... This coin, you gave me mine here. It has the face of Jean-Marc Seric on it. That's right. But these coins have all been recalled. So they are verboten by our governments since Marc Seric was... since our former president died. Yes, and I understand there's still a demand for them, for, um, private saturation. Well... It's a cruel world pottery mills, seventy-nine-silent sparse. Purchased from 1980 in Moravian China offers a coin in payment. Thanks. Thanks very much. The news. It's the news. Three of the latest great message from Moscow. Here you are, mine here. Our finest examples of Moravian China. And I warn you, they are very expensive. Yeah, I imagine they are, Father Angrunba. Would this be enough to pay for them? Who sent you? The news vendor on the Leninstasser. What do you wish? A way dependent on the Yakimov uranium mines. You wish to arrange the escape of Johann Werner. Do I? Only five of our leaders possess coins like that. Johann Werner is one of them. Also, he is in present at Yakimov. So? First, we must give you a new personality. That of Hans Obdahl. Hans Obdahl. Registration cards, police permits, ration cards, everything. And then? You will go to the Hradek Mineral Bas. For three days, at exactly two o'clock, you will base in pool number seven. Upon one of those days, somebody will contact you. How will I know when it's the right person? When you enter the Yakimov mines. Ah, it is pleasant in the Mineral Bas. Do you not find it so, mine here? One rest here. Relaxes. Help, darling. You know me? No. We have never been introduced. I am Anton Gora, by the way. Gora. But I make it the habit to inquire of the attendance as to the names of the other bathers. It always makes for an opening to a conversation. I guess it does of that. And now that I have opened the conversation, I can bring up the subject of the Yakimov uranium mines. What makes you think I'm interested in them? Our files, of course. By the way, I'm associated with the secret police. Yeah? Our files are most explicit in the matter of Hans-Optal. Very interesting.  You misjudge her, my friend. Froland Gruenwald's intentions were of the best, but she could hardly be aware that certain members of the secret police have infiltrated the underground movement. Ah. And now what? You wish to enter the Yakimov mines, Heloptal. I will see that your wish comes true. You who may have the opportunity of spending the rest of your natural life there. Don't want to go behind no iron curtains. Mr. Chief, honestly, don't. Del Schmidt, you're going into Czechoslovakia. But, Mr. Chief. Ken Thurston's been missing for four weeks. All our regular sources of information have drawn blanks. Now it's going to be up to you. But I can't find out nothing about what's going on in Czechoslovakia. Don't give me that. You've got cousins mixed up in every dirty racket in the world. You'll find plenty of them called back. Oops. What? What was that? The pilot's warning signal. You're going to jump. Jump? Oh, no. You've got a parachute. Oops. There's your signal. Jump. But, Mr. Chief. Del Schmidt. Hey, Joe Riley. Have you been in Yakimov now, Heloptal? Four weeks.  I lost count. After the second year. Yeah, I get what you mean. You have inquired of the grapevine concerning the whereabouts of a certain man here in Yakimov. I think perhaps I can help you. Oh. Leave your barracks two hours after dark. The third shift will be entering the mines. Join them. I can't get back into the mines, son of... The guards will stop me at the checkpoint. You do not have to enter. Just this side of the checkpoint is a tool shed. In there you'll find the man you seek. Johan? Johan Venner? Who is there? It's Ken. Ken Thurston. Ken Thurston? Ken, Ken, Ken, my good friend. Oh, how glad I am to see you. What are you doing here in Yakimov? I came to get you out. Oh, no, no. This is sheer madness, Ken. You have given up your own life for the sake of man. There is no possible way to escape. I spent four weeks and three days here trying to prove otherwise, Johan. I think maybe I've succeeded. What do you mean? You have found a way? Could be. But we'll need somebody to help us. Son of... Son of, we'll do anything I ask. Good. Then with luck we'll be free in Kalzbad by tomorrow night. So comrades, Sarnoff, they expect to be free in Kalzbad by tomorrow night. That is right, Comrade Gorah. That is why this man, Obdahl, wished to contact Berna to assist him in his escape. Very interesting, very interesting. It proves my wisdom in giving Obdahl enough rope to hang himself. Let us visit him at once. But they are desperate, Comrade. They will know I am a traitor.  You alarm yourself on duty, Comrade Sarnoff. Or did I neglect to inform you that at the end of the visit they will both be dead? We'll return to the man called X in just a moment. The United States needs the best qualified young women in our nation to do an exciting, interesting job. If you're a high school graduate between the ages of 18 and 34 with no dependence under the age of 18, you may be able to qualify for a career in the armed forces. If you can meet the qualifications, if you're above the average in intelligence and ability, learn the advantages of joining the armed forces now. Act 2 of the man called X starring Herbert Marshall with Leon Balasco as Pagan Zellschmidt. A sentence of life imprisonment in the uranium mines at Yakimov, Czechoslovakia. That is the result of Ken Thurston's desperate attempt to help Johann Werner check underground leader to escape from those mines. However, they make plans to break out, not knowing that the secret police have been tipped off as to their intentions. Did you see that Ken guards heading for the tool shed? Yeah, somebody's tipped them off. But who could it have been? Our friend Sarnoff was the only one who can... Yeah, who else? Lucky we got all that shed in time. Lucky, what difference does it make now that they know there is no longer any hope for escape? Is there any way we can get into the mine without being stopped at the checkpoint? Yes, there is one, an old exit shaft near the tailings. Good. Let's head for it. But Ken, what good will it do us to go into the mine? It's our only hope of getting out of it. It's our answer, Johann, the ore cars. I still do not understand. They leave the mine for the rail yards on this look for this gravity switchback. Then they made up the end of freight trains and hauled into Kasbah. Oh no, no, it is. No good Ken. They search every square inch of those trains before they leave the yard. They don't enter the ore cars to search them. You mean we should bury ourselves beneath the ore? That's right. But we could be crushed to death, perhaps suffocate. What do you think will happen if Anton Goro gets his hands on us? Well, Herr Sir Schmidt, you have come to Kasbah looking for a certain friend of yours. Yeah, you said it, baby. So how's about coming across with information or stuff, baby? The name is Freiland Greenwald. Oh sure, I know. He already told me, baby. So what about this nameless friend of mine, Mr. Thurston? What makes you believe we know anything about him at the Greenwald Pottery Mills? Listen, I got plenty big shot type connections in Kasbah, see?  So you better spill plenty before I give you a couple of degrees or two. Yes, perhaps I had. Well, your friend did come here. We sent him on to the next station. We have heard nothing from him since. That's a pretty kettle. And if I ever heard one now, where is this next place? The Hradek Mineral Baths. If you wish to learn about your friend, go to pool number seven. Be in the bath at two o'clock for three successive days. Oh, no, no. One of our people will contact you there. Okay, okay. No sacrifice too great, I always say. See you later, baby. Anton, this is Ilsa. Oh. I have just sent a visitor to the bath. His name is Ter Schmidt. He's looking for the other one. And listen, Anton, the other one's true name is Thurston. Thurston. Exactly.  How's it? Of course. If we had turned him over to the NKVD four weeks ago, they would have got all the credit. Now, we turned the man called X over to Moscow. I'm certain the rewards will be most generous. I do not like the disillusioned, you Ilsa. But Thurston has already made his move. Both he and Venor are missing. Missing?  How could you have allowed that to happen? Why be so alarmed, Ilsa? If they do succeed in escaping from Yakimov, they must help for Karlsberg. Ah, yes. Of course. And as I said, Anton, I'm certain the rewards from Moscow will be most generous. Venor's slowing down. Reach the Karlsberg yards. Just get off. Karlsberg. I have never hoped to see it again. We're not out of the woods yet. We've got to find a safe place to hide out. Then there is but one place for us to go, one person whom we can trust. You mean, Ilsa, Grunwald? Yes. Do not believe it. I can hardly believe it myself, Ilsa. Oh, to see you free out of the mines. Oh, it is like a miracle come to pass. You can thank Ken Thurston for having brought it about. Oh, and I do thank you, Herr Thurston. Well now, let's see. We will arrange a hiding place in the Bavarian Forest. A new headquarters from which Johann can guide the distance of our people. I'm afraid that won't do. What? I do not understand. It is Ken's opinion that I must leave the country. Leave? Czech or Slovakia? Oh, no, Johann, that is impossible. Why? Well, he's needed here too badly to give our people strength, hope for the future. He's needed for that on the outside too, where he won't be stymied by the secret police, where he can tell the whole world about the situation here. But, but, we would have to get you safely across the border. How could it be done? Where would you go? The U.S. zone of Germany. Just across the border from the town of Cheb. There are military installations there. It is the worst possible place to attend the cross. Not for military men, Elsa. Get us army officer uniforms, official credentials. We take the train for Cheb, midnight tonight. Look, baby, I'm tired of taking baths all the time. What are we going to go out and paint up the town anyway? If you will do me a little favor, Pagon. I think we can have some fun tonight. Hey, now you're talking. Go to this address. A man by the name of Anton Gora will be there. Just tell him that the two packages he's looking for will be aboard the train to Cheb this very night. So far it's so good, Ken. In one hour we will be in Cheb and make good out-of-scape across the border. It looks like it, Johann. Oh, you sound a bit doubtful, my friend, why? I'm wondering about Elsa Gunwald. How far we can trust her. Yes, sir. Surely you are not serious. She sent me to the minimal baths and Anton Gora showed up to arrest me. But she did not know that the secret police had killed her contact there. That Gora had taken his place, she explained all that. Can she explain what Gora's doing aboard this train? What? Ah, good evening, my friend. Do you mind if I share your table with you? No, no, come over here. Ah, thank you, thank you. Well, gentlemen, I trust you find the accommodations of our military train satisfactory. I would not wish you to be uncomfortable on your journey to Cheb. Mr. Axe? Ah, Mr. Axe. It was the bubbling tongue of a charmingly obnoxious aid of yours. Hey, Gonselchman. Yes, we found him most amusing. I'll bet. By the way, he has flown to Cheb with the lovely Ilsa in the mistaken belief that he will help you to escape from Czechoslovakia tonight. I am afraid the wait at the airport will be a long one for him. Yeah. So what goes now? Oh, it is quite simple here, Thurston. I shall see to it personally that the two of you make your way safely to the German border. You mean you will help us escape from Cheb? Well, sure. That's where his guards will shoot us down. Ah, you realize my plan then, Mr. Thurston. It's pretty obvious the man called Axe is killed wearing a Czechoslovakian army uniform while helping a traitor cross the border into the United States zone. Ah, what a beautiful yarn for your propaganda machine. Exactly. You will be a cause celebre. Prove to the entire world that your country is fostering war, spreading internal dissension and conflict within the borders of our peaceful nation. Yes. There's only one thing wrong with it, Goron. Huh? It's not going to work. Oh, my God! The platform of the car. Yes, I'm with you, Ken. This way! You know what? We jump. Oh, it is. You know, the whole countryside will be alerted. We will never get through the forest now. When you can't go through a wall, you've got to go over it. Come on, jump! But I don't get it, baby. You said we were going out on a town tonight. What are we doing in this Czech airport joint? I'm waiting for word from Anton Goron as soon as his message reaches me. We will be able... We will be able... ...to report to the commandant's office. We will be able... ...to report to the commandant's office at once. There. That must be Anton's message now. Wait for me here. I'll be right back. But, baby... Wait for me. Okay, okay. How do you like that? That leaves me out here in the cold, hanging on a couple of bags. Boy, what a time I've been having. No Mr. Thurston, no smooching, no money. Believe me, I'll be plenty glad to get back to the good old USA states. Okay, pay down and let's go. No! Mr. Axe. Yeah, come on. But where are we going? Back to the United States. But how? Keep walking over to that plane. We're flying out of here. The plane, that's an army job. They've got a garage for those things and stuff. That's keeping off a couple of headaches in the hangar. You'll find him again. Get him over there. Get him over there. But that's cute cookie, Ilza. We've got to wait. She'll be right back. Oh, you bet she will. The minute she runs, we're the ones who had her paid. Not Gora. Get her board. It's okay, okay. Harry, Harry can. They will be honest any moment. I have already had a call from the control tower. They've got it on intention. They're over there. Close the canopy.  Not there. Put under your hats. In 15 minutes. We will? Hey. Hey, how do you like that? I did it. I got you both out of Czechoslovakia. Oh, sure. Yes. Yes, we are out, Ken, and I am leaving my beloved country perhaps forever. You'll be back. Oh, you forget. It is in the hands of dictators. My people are enslaved. Don't take my word for it, Johan. Take a look at history. And a man who once said that no nation can exist. Half slave and half free. That goes for the world, too. You'll be back. Well, here is our star, Mr. Herbert Marshall. Thanks for being with us. And my thanks to Veronica Pataki, Will Wright, Lou Merrill, Harry Bartel, and Bob Griffin. Next week, an ancient Byzantine Bible and $10 million forced Ken to make a dangerous voyage that parallels the one made by Noah and his Ark. Fortunately, there's only one Pagon Zershmitibald played, of course, by Leon Bolesko. So join us, won't you, when next I return as the man called X. Good night. The man called X, starring Herbert Marshall, is a J. Richard Kennedy production with music by Milton Charles. The story is written by Sydney Marshall. This program is directed by Jack Johnstone. All characters and incidents on this program are fictitious and any resemblance to actual characters or incidents is purely coincidental. And now, until next week, same time and station, this is Hal Gipney saying good night for the man called X. This is NBC, the national broadcasting company.


What's good Joshua Ross back again with another video so make sure you check out ten greatest special guest referees performances of all time and this should be a good one From time to time referees or special guest referees are included into a few to I guess Enhanced to feud make things a little bit more unpredictable Than the regular referees that they may have for safe matches So we're gonna check this out appreciate all the love and support you guys have been showing on the channel Let's get right into this one This on the special referee is something we see a lot in wrestling A guest ref might be needed in certain circumstances where the rest is in the ring require extra control The stipulation can also be used to put one wrestler at a disadvantage Since this stipulation shines a spotlight on the ref it's common for the guest referee to be a highlight of the match So in this video we'll look at some matches where this happened as we list 10 memorable special referee appearances Number one Chris Jericho first we'll look at a match where the special referee completely stole the show This occurred when Roman Reigns wrestled Rusev on Raw in January 2016 Jericho had made himself the ref in an attempt to prevent the League of Nations from interfering And even though it didn't take long for the faction to get involved YTJ knew exactly how to deal with them Jericho proceeded to eject each member from ringside in a comical fashion With each ejection being funnier than the last Chris was so entertaining the fans nearly forgot there was a match That's it would end up Roman Reigns delivered a spear to Rusev to get the win Number two Sean Michaels the heartbreak kid has been guest referee for so many matches There's even been action figures made of him in ref attire Perhaps the funniest appearance as a referee came when he officiated Kane first Rob Conway on the May 1st 2006 episode of Raw the spirit squad were the acting general managers for the night And since Sean was one of their rivals at the time they made him referee wearing a May 19th shirt This was going to be tough for HPK given Kane's hatred of this specific date But Michaels had a clever plan Sean went to check Rob Conway before the big red machine made his entrance However, Michaels ended up dishing out a low blow to Conway before putting the May 19th shirt back in And then throwing Rob out of the ring right when Kane approached the mere sight of the day Infuriated Kane and he got to work on tapping Conway Michaels watched on while sitting on the top rope Conway then tried to escape but Sean made sure to throw him right back in the ring Michaels they grabbed the trashcan for Kane to use the big red monster smashed the bin off Conway's skull and hit a chokeslam Kane didn't attempt to cover though and got ready to leave until he was summoned back by that all too familiar date May 19th That's fucking stupid bro May 19th. Oh, I gotta kill him now The winner number three. Oh my god. The main selling point of Summersam 1999's main event was the appearance of Jesse the body Ventura as a special ref Ventura was the governor of Minnesota at the time and given that the state was playing host to Summersam Having Jesse as the referee made perfect sense Especially given the story being told in the build-up where it was made clear the body rules Ventura cut an impassioned promo before the bell I'm proud I was a wrestler and I'm proud to be here tonight Stone Cold Steve Austin would be defending his WWF championship against Mankind and Triple H Stone Cold and Mankind worked together initially, but this alliance ended after Mankind tried to hug Austin China's interference would prove costly for Triple H as Ventura took it upon himself to eject the ninth wonder of the world from ringside And the body is ejecting time Mankind took a hard bump to the floor and would be covered by Austin only for the game to break up the count with a steel chair Hunter then used the chair on Mankind much to venture his frustration as he in Triple H argued Shane McMahon ran in to help the game Shane ended up receiving a stone after his sevens but man was then thrown out of the ring by the body to a huge pop What was happening there was stone falls Oh man, you little bastard. I love it He got himself caught up in between the ropes but Triple H was able to set him free and I go upside down and I'm hanging in the ropes Upside down I can't get up. There's no reason logically for Triple H to save me Austin would then receive a pedigree Mankind then came back to attack the game and hit a double armed DDT onto Stone Cold And it was that that got the three count making Mankind a three-time wwf champion I Had left the ring Triple H began to unleash a vicious assault on Austin with a steel chair to end the show number four the rock A month following summer slam triple h rock as a special guest always a lair. You see Now I'm at the wwf championship. I forgot what it was bro. He's supposed to count the three or something like that one two It doesn't matter if I count the three Possession a tightly defended against the british bulldog on smackdown with the rock being the special Rock had been feuding with both competitors So it would be interesting to see how we officiated the match. The great one didn't disappoint First he attacked the bulldog then rock entertained on commentary and when he was called upon to count a pin Rock gave Triple H an applause instead of counting the four This resulted in the two brawling with each other ending with a rock bomb Bulldog then made the cover as the rock was on hand to deliver one of his most iconic lines Three bulldog attempted to use the wwf title as a weapon But it backfired as rock took both bulldog and the game out with the bell The brawler bull then hit one of the best ever people's elbows. Yeah, it's the slide It's the slide in the dress shoes one of the best ever people The rock posed with the wwf championship as the match ended in a no contest number five Chain McMahon the rock and triple h would get their big pay-per-view singles match for the wwf championship at backlash 2000 the game defended the title with vince and Stephanie McMahon in his corner while shane acted as a special referee The rock was at a heavy disadvantage of being attacked by vince numerous times while shane turned a blind eye The people's champions stayed alive though and responded with a ddt although shane refused to count the subsequent pinfall This is so good. This earned McMahon a signature right hand from the great one followed up by a double Vince's shock reaction said it all the numbers game once again caught up to the Rock with a low blow from behind following a pedigree Still being down on the outside vince signaled for the stooge's paterson and briscoe to come out However help was on the way in the form of a returning stone call Austin dished out some of the best shares that's ever seen And the crowd went completely insane back in the ring the rocket people's alcohol was going for the cover And just like that the rock was a new wwf I got goosebumps. Just I've seen that clip so many times. I still get goosebumps. Take me back Build a time machine so I can go back and watch that live He celebrated with austin to end one of the attitude eras most classic main events number six stone calls Austin was on hand to referee a match himself at WrestleMania 23 in the battle of billionaires Where the losing billionaire would be forced to have their head shaved bald vince McMahon who is you know, what's crazy He's the only president ever Former president ever to get stone cold stunted There's never been a president in in the history of the united states. There's ever been stone cold stunted, bro Can't make it up represented by umaga face donald trump who is being represented by Bobby lashley Stone Cold establishes authority early by pulling lash v off umaga Austin later got heavy-handed when pulling umaga out of the corner This infuriated umaga enough to hit the rattlesnake with a Samoan spike from there Shane McMahon interfered hitting lashley with a coast-to-coast Shane then revealed he was wearing a referee shirt and began to count however stone cold pulled Shane out of the ring and threw him in Austin was struck down again by umaga once he got back in the ring Meanwhile on the outside donald trump proceeded to beat the hell out of vince austin finally managed to dodge umaga And hit him with a stunner lashley then delivered a spear to the smoan bulldozer as austin counted the fall in the post match Shane would also resist Use this as an opportunity to escape however lashley quickly caught him McMahon then got a taste of things to come as he felt the bald head of stone cold and once vince turned around He too would eat a stunner It was then time for vince to get strapped in as the billionaire's haircut got underway vince's facials and bones whilst in the chair were absolutely I want to say this is right before he turned into durag vince Because he had his hair shade. I want to say this is right before he turned into durag vince and it just oh no it was Oh man gold The parting shot of mcman as he walked back up the ramp helped sum up what was an all-time wrestle menu moment Austin still had one more senator to get out though I told you being on the receiving end Trump took the move so badly that the camera angle had to be altered to try and hide the botch on the dvd in network versions of the show And it looked like And he took it like yeah, it still wasn't the worst. Yeah, it wasn't the worst Number seven mc foley foley put in perhaps the most physical special referee performance of all time bad blood 2003 where kevin ash battled triple h for the world heavy Can we just acknowledge the fact that mc foley's referee shirt was so bad? It made sense.  Let me spray paint this with stripes on it Loved it championship inside helenacell foley was made the ref after numerous senior referees refused to Officiate the match due to fear And the dangers of the sell itself so given the wars mc went through inside the structure There was no better man to ref such a match than the hardcore legend himself Foley laid down the law by stopping triple h from using a hammer Resulting in a shoving match between the two mc did however allow nas to use a barbed wire two by four mc Then stopped triple h from using the sledgehammer But this resulted in foley getting taken out by the game the cerebral assassin Then grabbed a sealed chair and hit both nas and foley across the head with it at this point All three men had been busted open nas was now back up wielding the seal steps He successfully used on triple h with foley also getting caught in the crossfire nas then inadvertently crashed into mc Who was on the apron as the hardcore legend took a nasty back bump into the cell wall nas used the barbed wire Two by four to his advantage once more before hitting a jackknife power bomb foley raised back in the ring to count the fall Even though he was meant to stay down this meant triple h had to kick out Which resulted in an awkward finish to the match where nas essentially waited for the game to strike him with the sledgehammer I never did that and triple h retained his world heavyweight title foley took so much punishment as the referee that this was essentially a Triple threat match Next we have an example of a special referee being drafted in to try and ensure the rest is in the ring Destroyed each other This was commissioner regal's plan when he made himself the ref for chris jericho and chris benoit's match on the april 9th edition of raw From 2001 regal put on a very entertaining display here from the way he rang the bell to the way he demanded jericho and benoit punch and kick each other instead of Underhooked backbreaker and then hooked the leg of benoit regal however awkwardly counted the fall since he wanted the match to continue Come on Regal didn't care about a winner as he waved to the crowd instead of counting benoit's pin attempt on a german suplex This made benoit push regal into an incoming missile drop kick The commissioner then lost his temper by punching out both white uj and the crippler But this proved to be a big mistake as the two chrises With a backdrop blindsoul and diving headbutt finished off with the walls of jericho It was fun to watch regal's entire plan He's just in the middle getting torn the shreds Oh my god, sammy zane next we go to raw in the summer of 2019 The matching question is unique in that it featured two referees with veteran official John cone working in the ring and sammy zane acting as a special referee on the outside Zane's good friend Kevin Owens took on the universal champion seth rollins in a non-title match zane made his presence Felt immediately first by patting down rollins before the match and then stopping seth from striking owens once the bow got underway sammy then distracted john cone just as rollins made a pin attempt After this zane even entered the ring to check on kevin But in doing so prevented seth from hitting a move off the top rope sammy would finally get caught up in the physicality When rollins hit a suicide dive onto owens once owens was back in the ring Rollins delivered a curb stomp and went for the pin zane got involved again though By this time pulling the inside referee cone out of the ring before he could count to three This angered rollins who ended up putting his hands on sammy which led to zane calling for the bell owens celebrated the disqualification win But his friend sammy wouldn't get off so lightly as rollins beat down zane at the help of a steel chair Zane was undoubtedly the star of the show here sammy later spoke about his performance led to higher ups seeing him in a different light And for some reason gorilla was very tickled by my antics or something in that moment You're just so entertaining. You can do anything. Number 10 He is entertaining Dude is He is hilarious, bro He you give him what you give him something and he'll make it Better than you expected it to and do this fantastic in the ring fantastic in the ring man Looking forward to seeing how things play out with the bloodline in him during this WrestleMania season We'll close things out with an example of a baby face special referee looking to screw over the heel This happened when dean ambrose was made the guest ref for aj stars' match against james ellsworth on smackdown in october 2016 before the mat could begin ambrose comically emptied his pockets by handing over each item to aj in the ring Once things got underway ambrose would have some fun by distracting aj to allow ellsworth to get a shot in on him Dean then tripped up stars and ignored ellsworth tapping out of the calf crusher to take a phone call Stars was none too pleased with this But it only got worse as ambrose fast counted aj while he was on the outside Dean then prevented stars from winning by count out by throwing ellsworth back in the ring Ambrose also took the time to sign autographs Which enraged the phenomenal one even more aj has to be commended though for how he saved ellsworth from injury When executing the stars clash ellsworth was headed for certain injury had aj not changed his body position at the last Following this Yeah, yeah, that could have ended Catastrophically for him bro cover but ambrose stopped his count at two He then gave aj the dirty deeds and pulled ellsworth on top of styles for the pin aj managed to kick out at two and a half This made ambrose leave the ring again to stop for a drink before coming back in the ring and hitting another dirty D's to aj which this time gave ellsworth the victory Hey man, this was a good one. This was a good one. It is something about the special guest referees You know it just especially depending on the uh the feud and the situation it can definitely enhance the matching And make it that more entertaining and quite unpredictable or if you're going in the situation to put Pretty much stacked the deck against the baby face. It does help in creating that Um that underdog story. So comment down below. Let me know. Yo, what's your favorite special guest referee moment of all time I appreciate all the love and support you guys have shown on channel row 250k and i am still your undisputed youtube personal champion world Appreciate y'all kicking with me. See y'all next one. Peace


Good morning, everyone. Welcome to our session on the Global Genetics and Genomics Community, or G3C for short. G3C is an online, unfolding, interactive genetics and genomics case study website that serves as both a learning and education tool. And in this session, we're going to provide a summary of the features of G3C, provide an overview of the different uses of G3C, and both describe and give you a demonstration of some of the cases and the content available in this website. In this session, you can enter questions at any point in the Q&A box and we'll address the questions at the end of the session. And this session is being recorded for future viewing. Speaking today will be Yi Liu, who is a genetic counselor in the genetics branch at the National Cancer Institute. And my name is Taffy Calzone. I'm in the role as a research geneticist and head of the genomic health care section in the genetics branch at the National Cancer Institute. So we will now go ahead and start the session. Hello, everyone. I'm Yi. I'm a genetic counselor from the National Cancer Institute, the Genetics Branch. Today, Cathy and I are going to give you an overview of an interactive online educational tool. It's called Global Genetics and the Genomics Community, short for G3C. As the increasing discovery in genetics and the genomics and is crucial for clinicians and the students are in training, how they integrate in those increased knowledge to practice and how to utilize in clinical care. Then we're thinking about what will be the best way for the learners to learn those information. Then through literature research and our clinical experience, we think learners can learn best when they're utilizing what they learned in the textbook and utilizing in the clinical care. So this is how G3C was born, which is we have a collection of unfolding case study for use with the learners. The learners can be students, can be practicing health providers, and they can learn the basic of genomics concept through interview, simulated patients, and through this process, they can complete a supplemental learning activities, such as practice how to answer those questions and the joint categories. And also, they can hear from the experts who are coming from the topic of this kind of cases to learn how they are addressing the current issues regarding those cases. There are some features, content of G3C. Right now, there are about 18 cases in the G3C website, and the cases can go through from cardiac, from prostate cancer, colon cancer, and the patient selection are ethnically diverse. The reason we're trying to mimic the community of patients we are serving, and also we are focusing on some common public health issues, such as the access to health care and others will be important in the clinical setting. And those cases are portable and web-based, and it's open access to everyone. So it's a free registration and it's flexible for people to use. The cases are interactive and self-paced. You can choose which question to ask the patients, and you can stop at any time. And the questions have different routes, so it's self-directed. And it's an unfolding case study, so it depends on which question you are choosing, and it will lead to different kinds of scenarios, how the story is going to be presented to you. Also, the professional actors and others will be used in the G3C as a simulated patient, so the learners can have similar kinds of experience when they go to a simulating center in an academic setting. In the process, there are incorporated learner education activities and the resources being provided, so that a learner can go into the activity and the resource to enforce what they would love to learn and enforce the knowledge and enforce the knowledge. And faculty support was included as well, and some faculties would love to use this website to integrate it in their curriculum to teach students, and some suggestions are provided by the new website. Once you go into G3C, you will see a login and registration button, and it's free registration, then you follow the username and the password, then you set up a count. In this way, it allows you to track the progress, and it enables you to stop a case and return where it left off. And here to share with you about some unique features of G3C, the first one is the expert commentaries. So those are experts who are familiar with the topic or the case is presented in a specific case, and they can address questions like how realistic the case to be a current practice and how the genomics information is integrated in the case. And or there is any like a conflict or controversies associated with the case, and also they would bring up like ethical, legal, social issues associated with the case. And the commentary are based on their experience and on their clinical practice, and also they will give you recommendations on what will be helpful for the learners to understand the topic. And here I'm going to share with you what's the flavor an expert commentary will apply. So this case is, again, really interesting because there are a number of controversies associated with genetic testing and autism. So the one that I'd like you to keep in mind as a clinician is our best efforts to look at genetic testing. In ASD, again, I mentioned it's a huge, a huge diagnostic category. There's so many different forms of ASD. So on average, when you do genetic testing for ASD, you get a quote-unquote positive answer. You find a genetic variant associated with ASD in that child anywhere between 15 and 30% of the time, 15% being in the lower end if you're using microarrays, and 30% of the time being on the higher end if you're using genome sequencing. So that means that 70 to 85% of the time, their family is going to get a negative result from genetic testing. So it's really important as a clinician to set expectations appropriately that the behavioral test to diagnose ASD is different from any genetic test, which is only looking for specific factors. Because when I talk to years or psychologists with years of experience, and they deal with families all the time, they order genetic testing in this case, the very first question that they get from the parents when the genetic test comes back negative that no linked variant was found is, so that means my child doesn't have ASD, which is not, we can't say that, right? All we can say is that we could not find a specific genetic cause behind the ASD that we've diagnosed behavioral in your child. So that's really important for you to think about as a clinician to be able to set expectations appropriately and be prepared to have that discussion with the family when those results come back. And here is another unique feature for G3C, which is the faculty case guide. So faculty case guide is a PDF that's inputted in each case, and it will have the case objectivity suggestions for users and the supplement student activity. And so the person who wanted to utilizing G3C in the teaching setting, and they can use the faculty guide to help them how to design the study part. And there are additional reading and the resources provided in the faculty guide. Here, I'm going to transition to Cathy and she will continue giving you a discussion regarding G3C. Hi, everyone. My name is Cathy Kelzone. I'm also in the genetics branch at the National Cancer Institute and work with Yi. And I'm going to continue talking about G3C and begin with how learners can benefit by using G3C. And the first is that there's a variety of different cases. So individual learners have the opportunity to be able to select a case that is either relevant to their practice or relevant to what they're learning about and be able to focus on those specific kinds of topics that are of interest to them. It simulates a health care provider experience and encounter. You are actually interviewing patients and you hear a response and you need to begin to integrate that into how you would think about how you would respond to a patient given those circumstances. And that's done in the mechanism of being able to select what question you would pick next, being able to do supplemental learner activities to help you understand some of the things that were brought up in the video itself and being able to actually simulate to the best that we can real-life clinical encounters. All of these cases provide some degree of learning basic genomic concepts and so that varies depending on the case. It's always case specific, but those basic concepts are actually very important as a foundation for utilizing genomics in health care provider practice anyway. And as the case progresses, there's the supplemental learning activities that can be completed and then there's the opportunities that can be completed and the opportunity to hear from experts that are well recognized in the field about their view of the case, how real it is, what kinds of controversies and so forth that are involved with the case. So how is G3C being used in real practice in an academic or continuing education environment? And we've actually learned a lot from users of G3C about how they've been able to use it in a variety of different ways. So let's start with the academic setting and begin with how different faculty have integrated this into lectures and that is to pull out specific case points that they're trying to hone in on and to reinforce some of the content that they've actually taught their students already and didactic content. Some of them have utilized student assignments to explore specific case and that can be an assignment within the classroom environment. It can be an assignment that is a homework assignment or a pre-work assignment prior to class. There can be faculty guided activities where faculty members can actually show a video clip, stop the video, and then have a classroom discussion about the controversies, the ethics of the case, the kinds of issues that were brought up, some of the psychosocial considerations that can be an engaged discussion with the learners or it can be in small group activities where you show a video clip and then break into small groups and the individual groups report on different aspects of a given case. We've had a development of cases that are multi-ethnic and that was very deliberate because that's much more reflective of the kinds of patients that all of us would see in practice. It's a variety of different ages and a variety of different conditions that these people have from common health conditions to more rare genetic kinds of conditions that one might encounter in practice. All of these cases include some degree of assessment and so that's actually important because an assessment provides faculty with an opportunity to examine student's capacity to do these assessments. For example, can they create the pedigree? Are they able to assess family history sufficiently through a case? Are they able to assess risk based on the information that they've collected throughout the case? Can they gather all that information and determine whether or not there is an indication for a genetic test? And if so, what test would that be and how would they proceed in regards to moving forward with the test? And you can engage at any point in discussion with the learners. In group education, you can divide into groups and have groups actually complete a case as a group and go through some of the supplemental activities and discussion points. There can be additional faculty activities. I've never been so surprised by the novel ways that faculty have been able to come up with what kinds of additional activities they could add to these kinds of cases to make them interesting and as real life as possible. We've also had a number of people use D3C in a continuing education capacity. That includes just independent learning that an individual sits down and actually does a case because they're either going to see a patient like this or they know that this is an area where they have a deficit and they need to improve some of their knowledge base. And we provide a lot of faculty support and that includes faculty in the broadest sense of the term, both in academic and continuing education environments. So in addition to what you presented about the faculty guide that is case specific, D3C provides a large number of resources that are very helpful in just understanding, you know, genomics and basic resources. A lot of these are resources that have been developed by the National Human Genome Research Institute, such as the Talking Glossary, the Image Gallery and other kinds of things that faculty could find very useful in sort of planning how to integrate these kinds of tools in practice. We also provide an introduction to D3C, really talking more about this kind of experiential learning methodology as a way to stimulate thinking about how you could use it. There are website overall objectives, so in addition to the case specific objectives that you spoke about, there's overall website objectives, target audience and suggestions and how you could actually use D3C. And each case, like we've mentioned, includes resources and supplemental activities and additional educational activities and the individual case guides. So the latest case that we have developed is on autism spectrum disorder and vaccines. And this particular case, if you look at the picture of the actress here, what you can appreciate is that this actually, if you were looking at some of these slides as they were being presented as somebody that we've utilized before. And that's real life, right? We see patients at a variety of different time points depending on what could be occurring in their life. And so now Dai, who originally was seeking consultation in a prenatal setting, is now at the point of having a four-year-old son. And she is presenting for a discussion because he has what appears to be increasing developmental delays. He has speech and language difficulties. He's very hyperactive. He has a lot of psychosocial issues. He has a lot of difficulty engaging with other children. And she's very concerned about these developmental delays and his behaviors and what may be causing this. And so this particular case delves into the genetics of autism spectrum disorder and fragile X. And the objectives, of course, is how best to respond to Dai's question about these issues, including her suspicion, well, maybe it was associated with vaccines and how genetic information and testing could actually apply to this particular case and that this would not be associated with vaccines. So we're going to actually show you a clip from this case so that you get a real feel for what this actually looks like on the website. Well, Ethan has had a speech delay, for instance, at age two. He couldn't form three to four word sentences. At this point, he can say phrases, but he tends to repeat them a lot. He says, I want that over and over again. He has short bursts of speech with disruption in the flow. So he repeats a lot of sounds and words. So I'm going to conclude here. And I'm just going to mention that, you know, yes, Yi and I are from the National Cancer Institute, but G3C is something that has been a longstanding collaboration between the National Human Genome Research Institute that provided the expertise and funding and platform to continue to develop G3C and bring it to you all. And we're actually very excited to continue that collaboration going forward. And we're happy to answer any of the questions that you may have. Well, we are happy to answer any questions. The link to G3C is in the chat so that you're able to, you know, just, you know, click on it and bookmark it easily enough. I don't see questions right now, but I think one of the things that we'd be happy to do is to actually show you a little bit more of these cases just to give you a better flavor for it. You know, this is all about, you know, the reality that in a learning environment, be it academic or continuing education, you may not have an opportunity to see these kinds of patients. And this is the best, not the best, but the best methodology that we could identify that was feasible to achieve and timely to be able to introduce these kinds of cases on the website methodologies. So I'm going to share my screen. And we're going to start with dye and be able to help you understand when we first encounter dye in the prenatal setting. I just found that I'm pregnant. So I'm coming to start prenatal care. I work as a clinical nurse specialist at my hospital and I'm definitely a planner, so I want to get things as organized as possible. So one of the features that you can see is this is how the question options open up to you. And we're going to pick this question because this was one of the reasons she wanted to start. I'm really concerned that since my husband and I are older, that that might affect the health of the baby. And I know that the California panel is only a small number of tests, whereas the whole genome sequencing has a much larger scope. And I also understand that whole genome sequencing can take a long time to set up. So that's why I'd like to get started so early in the process. Kathy, I saw there is one question showed up. It's Alison asked about which professional or clinical groups are the modules geared towards? Yeah, I think, yeah, go ahead. No, you can answer. Oh, sure. So the professional and the clinical groups and we are focusing, I think, on like two kinds of setting and the one is continued education and who are like, for example, like either physicians or nurses or professional genetics and they are already in the clinical practice. So they can utilizing this to either explore topic and like or updating information they may feel needed at this point of time they do not learn before. And the other section is the students who are in training and like which reflecting the like professionals I talked to before. And yeah, like physicians in any kinds of settings of nursing capacity and from general nursing to professional nursing and also in genetic counselors and training and I think will be it will be useful to using this website. Yeah. And I don't think I have anything additional to add, but I think the the key point that you brought up which I'll just reinforce is that this is for really any kind of health professional or student group who's training in the health professional capacity to be able to use. And that can include faculty, you know, we have found that certainly in, you know, my background is in nursing uses in the genetic counseling profession so it would be different in that setting. But in nursing for sure, we have found that a lot of faculty have difficulty teaching this content because they don't understand it themselves. And so sometimes these cases have been used just for self learning and preparation for teaching about these kinds of issues in the classroom setting. And so it expands across all groups who would be able to use these modules. They are intended to be basic and not highly technical and highly advanced because of the fact that we want to be able to reach any group in any profession across the board. Yeah. And we do have additional reading or resource and so they can explore if they want to advance the knowledge on that. And the experts commentaries and they are all like experts who are familiar with this topic and understanding the current like either research or like standing for this kind of issues in a professional setting. So definitely you can go from basic and to like advance if you wanted to explore some more. Yeah. And thanks, Alison, for the question. Yeah. And I think we have a very interesting question from Mexico. Yeah. And so this question is, is it ethical for companies, banks to have genetic information about people and because it could generate a kind of discrimination? Yeah, definitely. And for example, and giving a health insurance to someone who is likely to suffer from cancer. Yeah, I can comment on the GINA perspective. So there is a non-genetic discrimination act in the U.S. But I do not know like what is the standard in Mexico. And there are a broader like umbrella for protection regarding who are not someone who don't have the symptom showing only carry the genetic change. There are certain like protection for people getting like health insurance. However, like you brought up a great point on like there is no like the standard protection regarding life insurance and also it does not apply to military as well. Definitely, there is a like a very importantly how health providers and in the community, how we providing like the information regarding genetics to people who are interested for genetic testing. Now, Kathy, do you want to comment on that? Yeah, I think one of the important points here is that this is complex. It's very different depending on the country. And even within a country like you said here in the United States, there are people where these laws don't apply and there may not be laws in places like Mexico or other countries. The key thing here is that, you know, this is a changing landscape in many different places. And so what's important in thinking about the use of genetics and genomics and in care is that they're having an encounter with a trained healthcare provider, whether that's a genetic counselor, a geneticist, or a genetic nurse. They need to see someone who has a handle and a knowledge base on what's the landscape in that particular country and that particular environment. I do want to make a comment about like, for example, predisposition to cancer and other kinds of diseases. One of the things that's important in thinking about this is that, you know, that risk is there. And we all have a risk for something, right? And what that is being used for is to inform healthcare decision making to either detect that disease early or intervene early to minimize its effect or be able to modify that risk in some way depending on what the nature of the problem is, you know, it's cardiac condition versus cancer. And so there are many different ways to think about this and not all of it is negative, just knowing that somebody might be at risk for something. It's also informing their healthcare and there's an advantage to that. Not everyone sees it, but there is an advantage and that's why it's so important that people need to see somebody who has an expertise in the environment to be able to explain that to patients so they can make an informed choice based on their environment and the landscape in their country. Yeah, I think Kathy brought up a good point regarding the informed decision making and a professional is able to explore all kinds of either benefit or limitation or risk like about the genetic testing to someone who are thinking about having tests, I think it's very important. And also another thing I think is worse to mention is the people make a decision on genetic testing maybe have a long period of time maybe like a month or two years or three years. I recently had a patient like took about two years that he finally like thinking about his time for him to do genetic testing. So it's as a professional maybe you are not expecting someone giving you an answer immediately. Yeah, it may take a longer time for someone to make a decision. Yeah, I think we have another question. Kathy you want to address? Yeah, so this question is what kind of outreach are you doing to get this to primary physicians and the clinical settings where physicians may not be aware that this resource exists so they can be better planned. They are cared before they send a referral to genetics. So there's a number of outreach activities that are going on both you know that are discipline specific and across all disciplines and I'll highlight the one that we're doing today and this whole week which is the health professional genomic education week that is hosted by the National Human Genome Research Institute to try to engage people as broadly as possible and have these kinds of tools available so that individuals even who participate in this can disseminate this because these these sessions are being taped and are going to be available on Genome TV and other links through the genome institutes for viewing by others who did not attend or didn't hear about it for some reason. We do spend a lot of time both on the side of the genome institute through the ISCC PEG which is the Inter-Society Coordinating Center for Professional Education and Genetics and I probably messed that up and I apologize. ISCC PEG is much easier but that is the platform that in part not in total but in part is being used and is a mechanism for engaging all health professionals pharmacy medicine and others to understand this better to have experts who can begin to develop more resources for education and training who are trying to disseminate within their practice specialty to upskill the capacity and competency of that group and there is a need for more people to engage and participate in ISCC PEG which is a great mechanism to be able to work with others and think about novel ways that could be used to engage these communities because all of us appreciate that there is a deficit in the number of people who could benefit from the use of genetic education and counseling and possibly testing but that they're not getting the information that they need to have a referral and think about what can be done. You know all of us are committed to you know different mechanisms that are being used like through the National Society of Genetic Counselors where they're working on a variety of different outreach efforts. The International Society of Nursing and Genetics and the Global Genomics Nursing Alliance both are international groups with a similar mission of trying to move this out in the nursing community is another mechanism because many of these you know physician providers do not work you know alone in their practice and they have nurses that work with them and so trying to get you know this out from grassroots kind of perspective and increase that capacity. So there's a variety of things that are going on and we are you know always welcome to hear other ideas and strategies that haven't been considered but I'd encourage all of you who are participating to think about joining ISUCPEG as a mechanism to engage in this activity. Yeah Cathy I think last point we brought up about we are interested to everyone contributing in this effort and there is one participant Adriana and if I pronounce your name wrong I'm sorry yeah and then the proposal is would you be open to collaborating on the project to have this program available in other language such as the Spanish yeah I think what we thought about this a long time ago we would love to right Cathy? Yeah we'd love to we we did have one case that actually was done in Spanish it's difficult for us because you know I will say one of the genetic counselors in my group does speak Spanish so that's good but you know it is difficult for us to both maintain that and to have the right resources so we would be very keen about working with people in other countries to you know disseminate a resource like this that could be used and modified for use in other countries so that is something I think that we're very open to being able to do and that's partly some of the work that you know even ISCC PEG might be thinking about because even here in the US we have you know a highly diverse population and different populations that you know do not speak English as their primary language and they have a lot of difficulty understanding some of this so it is the kind of thing that we're quite interested in yeah but you just have to reach out to us yes yeah we yeah go ahead well I was just going to say we'll put our emails in the chat and and then you can always feel free to email us so yeah we'd love to collaborating and bring this platform to be a reach out to more community and to benefit the people who wants to learn those knowledge yeah and the Luis had a question about the on what do you think about the you you genetic genetics yeah so I understand where you're coming from from my perspective and the real we are really focusing on like a disease prevention and how to manage your condition definitely is not to trying to go through the route to limit relating about the variety of genetics of our people yeah and for for the genetics community right now like we are focusing on information now that it's a we are able to approach and there is a management like a own place can tell someone like for example starting screening earlier can detect the either cancer or detect the other kinds of condition to happen and or like is there anything like like for example in pediatrics if we identify the some genetic change we could like predicting like they don't want something while showing up before the child and there are different kinds of interventions that can be utilized in the overall management for the child and for example like the some some are not just showing as a physical like a condition you can see they can be like a mental as well so on the line they will be like interventions about seeing a mental health provider where things like that can be helpful as well so the whole idea is in genetics I think from right now the standpoint it is about to prevent like a medical condition we can manage it to happen and or we can manage it better when it does happen yeah so Kathy do you have any comments now I think it covered it so um I see um yep okay yeah so I think one of the things we also want to do is kind of show you just the scope of these kinds of cases and I'm gonna and it relates to some of what's been brought up here today so I'm going to share the screen again and just give you a flavor of another case just to um help you understand some of what is there but I have too many way too many things open so I'm trying to get to well uh I'm here for my yearly physical and uh I completed the ACT for Health and you know the WebHA and found out that I'm at an increased risk for breast cancer my dad incidentally was um found to have the mutation BRCA2 which I was under the impression that that can only be passed down by the mother side of the family so we found out that's not true right and really I think the reason that we're here today is for me it's primarily because I'm concerned about Jeff's health and I guess I just want to make sure that you know we get this thing squared away Jeff didn't tell me about it until recently um so this is really I guess new to me also I got a genome scan like I don't know a couple months ago so I know a lot about genetics and so I feel like I'm I don't I mean I just found out about this but I'm here to learn more is really why we both are and we're a little nervous about the genetic testing and the implication of the BRCA2 because of what it could mean for our two kids right that's my primary concern I'm over here yes so I wanted to go ahead and show this particular clip um for a clear reason in relationship to what was discussed um and if you go through a case like this we do try to integrate different kinds of concepts throughout the cases including ethical issues in the majority of these cases and in this case the issue of discrimination and concerns about discrimination came up quite a bit because this individual actually the male is in the military the individual who was considering the genetic test and was there with his wife and you can appreciate that there's you know a little bit of tension between the couple because he didn't share this information and she only learned about it recently and so some of those kinds of things come up in the case um and so there's a lot of different avenues for exploration both if one just does the case but also being able to pick out different components of the case and show that video and engage in discussions which can be very country specific um or environment specific about what would be relevant in a particular country on comment yeah sure yeah so as uh as also we know that for BRCA 1 and 2 and the Lynch syndrome and familiar hyperplastroemia as the three condition was on the CDC like the front line trying to for cancer prevention and um expanding the screening for population and I think this also address the comment I had before he's really focusing on something like we are trying to think something we can use through genetic testing we can prevent either to happen or catch it early like we know like the BRCA 2 it is associated with for males prostate cancer pancreatic cancer and melanoma and and so for for those especially for prostate cancer for BRCA 2 is starting at age 40 and for for for PSA screening and the digital record event and which is earlier than the general population starting at age of around like 45 so have this finding have the the finding can help this male regarding the prostate cancer like a screening start early and if you catch it early and it's a really will be much more easier to manageable compared to later and yeah so that's the product a point to regarding that and also the for female the BRCA 2 associating well be like breast ovarian and and that like can help with the management as well yeah so I want to just highlight a couple things from the chat and that is that dana has gone ahead and put in information and the hyperlink to the inter-society coordinating committee for practitioner education and genetics and that they're always welcome to have applications and and there's no fee to participate and so that information is in the chat and you can also just you know follow what's happening in the ISCC peg you know through their website I can share a model case for more like features we can have I'm Kathy I'm showing I'm showing my screen yes okay wonderful yeah so this case it's a lady with potential um um hyper um um with a familiar hypotosteolemia and um from when we go to the case page then we will have have a and some some like the description regarding this uh patients and when you also we will have a link about the uh case note so it's all PDF and able to download and so you can you can see a form like this it's uh showing and for this case first uh usually you begin the case is what brought you to the office today and let's take a look well I was referred here by my gynecologist I went to see her because I got some abnormal cholesterol results from a health fair that I went to so she told me to repeat the test but without eating or drinking anything beforehand so I did and I was told the result of that would be here today um and to be quite honest I don't remember ever having my cholesterol checked before so I was a little concerned with the numbers that came back yeah as you can see here for Larissa we picked uh we choose the Spanish speaking immigrants and also she doesn't see a regular she doesn't have a primary doctor she used the gyne as her like an annual like a check-off and it's very common um like in the community and um the other like points we wanted to show is um sometimes if um in in the in this kind of family and sometimes the information can be family information can be limited so in the in the education um this process we're trying to integrate in those kind of cultural like relevant to um to the the case so um learners can have some idea regarding the cultural components regarding the case not just see the patient as as a disease condition yeah so and there is a another feature I wanted to share with you is and we so when we go to the case this is how you will see in the website and there are different cases showing up so you can you can filter the case through a category and and also like like you can see here there are the heart condition there are our cancer risk assessment child case cystic fibrosis and and the the factor five laden and diabetes and so you can choose from a different variety depends on what a kind of condition you are interested and also there is a menu regarding you wanted to be more advanced the case intermediate so so it's very um it's viewed out to as a learning like a purpose and when you go to go through all the case there is another feature I wanted to show you which is the recommend maker recommendations so that's the way that this website is set to assess your knowledge when you go through the case for a period of time that learned enough doing enough learning activity then you could have some ability able to make recommendations so that is how it's an assessment that the teacher can sign for students to do and and they can so this is how it looks like yeah like a different it's a multiple choice section yeah I'm trying to stop yeah so I don't see any other questions coming in but certainly we've given you the email and you're welcome to go ahead and and contact us with other questions um the link to g3c is in the chat um and we are working on a new case we do you want to describe that case oh sure yeah so um we right currently we are working on the case that is associated with um hyper um it's associated with a cardiac syndrome and we are trying to focusing on the native american population so have cultural elements regarding the some of the elements of the professional encounter with someone with a native american background what kind of information they should keep in mind and and and also with the prevalence regarding the cardiac condition and to think about what kind of genetic testing you can offer and and also how you can refer to a geneticist for or genetic counselor for ordering the test and in this whole route and things so we should be aware how cardiac condition associated with genetics and also with a native american background and and one of the other features associated with this particular case is the issues associated at least here in the us um the native american population has a specific health system which is the indian health service um which is different from other health systems within the us um and there is concern about um the use of genetics and eligibility to continue to be able to get their health care through the indian health service um and so what you can appreciate throughout all of this is that you know our objective is to try to integrate a variety of different kinds of issues into these cases um and and that actually mimics real life because you know patients don't just come in with a particular issue there's a variety of different considerations for every patient um and so we're trying to make sure that what's developed is reflective of the broader population as a whole and the kind of challenges and considerations associated with those things yeah so stay tuned yeah i think we have the last question yeah who is coming from louis i just learned that you are a high schooler thank you for joining me and um the question is like why do you decide to be a researcher yeah um yeah for me i think um i wanted to explore what is um um unknown and it's so much so much like we do not know and we're trying to find the answer so i would love to be the person in the puzzle of um finding what is the reason maybe i can answer some of the question in the end but maybe i will be more confused but in the process it is very like interesting for myself and also i i think very importantly it's a public service like how to serve the community and very importantly it's i love to work for coming from the community and learn what the people are need and how research can meet the can reach the end for what what what is needed in the in the people we're serving yeah and and for me the the motivation to become a researcher was really about trying to identify things that work right i started in oncology i've always worked in oncology and being able to identify things that work treatments that work you know symptom management that works care delivery that works um and the only way to get at that is to study it in a systematic fashion because it's not just he said she said or you know well we did this in our setting and so that's what we do here um and so that's what drove me to wanting to be a researcher now i always worked in a research environment and if you have an interest in research i'd encourage you to look at some of the resources through the national institutes of health at nih.gov um where they also offer opportunities for students to experience the research environment like the summer students and post baccalaureate students so there are many opportunities for people to be exposed to you know a research intensive environment through the national institutes of health and it's nih.gov and then if you put in like summer students or something that is the the link for those kinds of things but nih.gov is the the platform for being able to provide that i can try to um put in the link in the chat or student specifically but all institutes the genome institute which hosts g3c and is hosting this genome education week as well as the cancer institute and all of the many institutes within the nih are very focused on um these kinds of trainings and uh me and dana put in the links um so that you can look it up thank you for all those questions and thank you for joining our session yes yeah feel free to reach out to us um if you are interested in any like topics we addressed today or you have some innovative way how to um expand the g3c we would love to hear thank you thank you


Hey what's up guys welcome to trending reviews so I just want to start off by saying a very happy new year to everyone and kicking off the new year I want to give you an introduction to my very first ultra-wide video. On the back of that I want to also do a review of my best gadget that I bought in 2018 which was the DJI Osmo Pocket and give you the best accessory that I bought for it up until now which is the Freewell Osmo Pocket filters so let's take a look. Right so just kicking off what exactly is the Freewell Osmo Pocket filters so essentially when you go out on a hot sunny day you go to maybe a hot destination with your SLR camera you tend to buy a filter that you put on the lens to prevent UV rays from damaging your lens it's similar with the Osmo Pocket it is a lens and you do want to protect it from heat and also from very bright sun washed lens flares and that kind of stuff when you come out and view your videos so Freewell are an awesome company they've got little filters that are magnetic that stick to the front of the the lens on this gimbal here and they cover various different sun environments outdoors so if I just quickly show you so there's six in this box they cover various different amounts of sunlight conditions outdoors if I quickly show you the box that it comes with it gives you an overview of all the different lenses that come with it and all of the weather conditions on the best time to use those specific filters and it gives you an example of what type of weather environment outside you should use which specific filter so for example on cloudy days you should use the ND4 filter then on partly cloudy days you will use ND8 then on normal sunny days ND16 and they go to 32 and 64 and you also have a neutral one that just reduces the glare in general so I basically use this here in London in cloudy days and also partly sunny days as well I haven't used the ND16 or 32 or 64 because we don't have such bright sunny days here in London but what can you do but I'm going to give you some sample footage of using these lenses before and after on the Osmo pocket on cloudy days using ND4 and on partly sunny days with bit of cloud using ND8 just to give you an example of the difference in the image and video quality that you get so ultimately it basically reduces a couple of f-stops on the actual filter and basically you can see a bit more sharpness a little brighter coloring on the videos some of them might be a little bit subtle but ultimately it gives you a bit of a protection and a bit of a clearer image when you're seeing the videos after you shot them so right now I'm going to go through both of those different filters that I've used give you some sample footage and hopefully give you a review straight after looking for you now and then someone just like you who can make me feel the way the ocean you're the rain we only need each other baby you know we're the same let's run run away I need is you now and we don't need no one else than each other you and me you and me I'll stand each other you and me you and me hey what's up guys so this is the selfie camera without the filter attached to it hey what's up guys so I've got the filter attached to it so hopefully you can see a little bit of the difference I've got the sun shining right at me right so I hope that give you a clearer understanding of the capabilities of these filters so for me I found them the sometimes you might find them a little bit of a subtle difference in them but actually overall when you're editing them after you've transferred them over to your laptop you can see the quite a bit of a difference on the editing as well so adjusting the colors is unnecessary when you have the filters on because they come out really clear now if I just show you an example I'm just going to pull one out here now they actually are very easy to connect to the actual gimbal as well and the magnetic so you could always make sure you use a cloth this actually comes with a cleaning cloth as well in the case so it always keeps your filters clean and tidy so you're always visible at all times and all you have to do is basically just clip it push it into place and it's magnetic this doesn't actually get in the way of any of the gimbal movement so when I'm turning it on you'll see that it won't actually hit any of the bottom of the sides there we go so it looks like that if I just show you there looks pretty cool and you also have the ones for the ultimate sunny days so if I take this one off literally just comes off put this one on so if you use the ND32 or 64 filters it actually comes with a rotating bezel there for the filter so that when you have your phone connected you can actually see on the screen actually the difference of the ISO and the aperture and the brightness levels that you can adjust accordingly for that filter this is mainly used on super bright hot sunny days where you just have a lot of glare coming through all of your videos so you can adjust that level yourself on the filter as well and it doesn't really fall off you can literally put it into the actual carry case like this as well it's so minimal you won't even remember that you actually got a filter on it so it's definitely recommended if you have the DJI Osmo pocket then I recommend you get some filters to protect the lens as well the last thing you want is if you're on holiday you're using this on sunny destinations to have the lens damage from too much UV rays or a lot of bright light and that kind of stuff so although it gives you good protection it gives you awesome footage as well so ultimately I've started using this full-time even on cloudy days it will just make it a little bit better even though it reduces the actual aperture a tiny bit depending on the filter you use I would definitely recommend it so you can buy the four pack for around 70 dollars and you can get the eight pack of filters for around 130 dollars so I'll leave a link in the description below for where you can buy the Freewell Gear and do check them out they are an awesome company and I do recommend this for everyone so I hope that was useful guys I hope you liked that review if there's any other questions you'd like to ask then please drop a comment below I've got tons more reviews coming up for the Osmo pocket and more accessory reviews for this in 2019 so I hope you subscribe so you won't miss that one other than that I hope you liked the video and I will see you guys next time take care