Hey there friends. Thanks for checking in today. We're going to do a range comparison with the springfield armory 1911 DS prodigy versus the CZ shadow 2 and you may think this is a not comparison a 1911 versus a double single action handgun But if you look at the barrel length, you can see they're very similar 4.9 inch barrel with the shadow 2 5 inch bull barrel with the DS prodigy both all steel frames Both I consider best in their class and even the price The MSRP anyways is pretty similar. Let's start with the prodigy I consider this springfields best handgun launch yet very exciting And I was super thrilled to get it it ships with a 20 round mag Which is right here and a 17 round mag 26 round mags are also available on Their site forward serrations already mentioned a five inch bull barrel Full length two-piece guide rod This can be purchased with this hex dragonfly red dot on there Now if you go with that, which is an ALS system agency optic system agency arms Collaborate with springfield to make this happen. You're looking at 1700 bucks with the red dot you will notice that with the CZ the prices are similar and all polymer wrapped Grip flatmate spring housing that is checkered within the grip and a five pound Trigger pull maybe a little bit lighter But that short reset that so many people love and come back to with the 1911. I Think they did a phenomenal job. I love this gun without the optic cut. You're looking at $1,500 double-stack nine millimeter 1911 All right out of the case. I didn't even have to adjust the red dot. I Was surprised usually you have to tweak it a little bit. I didn't have to do that with this handgun sericope black Looks great all steel frame But the CZ shadow to is much loved better on longer people love this to 4.9 inch barrel all steel frame. This is the black and blue model with the blue aluminum grips This Has a 17 round mag the offer three All right, and the plus two base plates work with these so you can Stack 19 rounds in there the MSRP on this model without the optic cut in the slide is $1455 it has raised a little bit throughout the years and Primarily it's an inflation thing. You know the gun market is getting affected by inflation Supply chain and Everything else that we're dealing with today, but it's a fine-hand gun forward serrations fiber optic front sights rate of black rear sight The rear sight is called hajo height adjustable only so you can raise it lower it For elevation whatever the case it has an ambidextrous thumb safety All right, which will lock up the trigger and the trigger is Pretty phenomenal the single-action trigger pull is right around three and a half pounds very light with a Reset like that people love the CZ triggers. I love the CZ triggers and This shadow to even the double-action is so nice. They now make this optic ready 1615 dollars all right, so that's why I say the price aligns fairly well 1700 with the optic 16 fifth 16 15 without the optic with the CZ so You have to put your own optic on there. That's an additional cost. You're looking at closer to 1900 2 grand Depending on what optic you go with but let's go ahead take a few shots with the shadow to love this Yeah, both of these are Phenomenal and both I consider high-end all right. They both look nice. They're priced similar They they feel right around the same weight 1911 double-action single-action both great competition handguns Overall, you just can't make a bad choice now I will say the 1911 DS prodigy is priced very low Considering the competition if you look at what's out there and the staccato line in the masterpiece arms line And others under two grand is a great deal The shadow to is a phenomenal handgun both of these like no recoil at all So which one would you choose and I will tell you which one I would choose First off, I'm proud to have both.  They are great. I love that single-action trigger pull. I love the reset I love the overall shooting impressions Disassembles a little more difficult with this as with most 1911's it's actually quite easy But compared to the shadow to or most cz handguns it would be considered a few more steps to take whatever Disassemble little easier with the cz shadow to love the aluminum grips love the polymer wrap grip Mag capacity about a round or two different difference depending on which way you go Both forward serrations fiber optic front sights both Really nice handguns. I hope I demonstrated that well. So I'm a 1911 guy I like the 20 round mags and I would go with the 1911 ds prodigy that red dot ready Already installed for 1700 bucks. I think it's a great deal ambidextrous thumb safety Not sure I mentioned that I did mention that here. I love the shadow too. I think it's a phenomenal handgun So proud to have this and I think both of these are great and you really can't go wrong They're they're high-end handguns. What I really want to know is which one would you choose if you like videos like this Please subscribe and share. I always appreciate thumbs up button. Thanks for watching and you guys be safe


Hey everybody, I hope you enjoyed your beer and or candy So before I get too far into things I want to thank my company and Visium because Frankly until they actually prodded me to do this talk. I really wasn't sure I was going to be able to pull it off And they actively encouraged me and so I probably wouldn't be here today if they hadn't really convinced me I could possibly pull it off So I don't know if you're you like your applications to be secure, but you know if you do then we can help with that So you should talk to me later so I've been thinking a whole lot about choices lately and There are times in our lives where we we encounter a fork in the path Where we we stop to take stock of where we are Decide where we want to be and then we pick a direction that we think is going to help us get there now Sometimes the choice is really easy because you know the choice seems trivial or obvious For instance, I have a standing policy that the answer to would you like to have a cookie is always yes But sometimes it's trickier The choice is obviously important But we may not even feel as though we it's really ours to make and you know just last week I went in for a regular cancer screening that I've been doing for every several months for the past past two years now and For those don't already know from Twitter I had testicular cancer and I I suppose I could choose not to do these these screenings But it doesn't really feel like a real choice that I have You know that being said don't feel bad for me because I had a lot of fun with my cancer first off, you know testicular cancer is highly survivable and secondly You get to make all kinds of horrible jokes and nobody can say anything to you because it's like Hey, you know I have cancer Um, you know my wife is a saint for putting up with me during that time. She really She really is And you know and for at least the first few days the puns were nuts they really were You know after that they were just not of course so Anyway a few months ago Terrence tweeted this at me and I had a choice to make And you know months before this is there's some backstory here because months before at rails con I talked to Terrence and Davey about an idea that I had had for a talk and you know Terrence knew what I would be presenting on if I Submitted but the problem was that it was going to be a lot more work than any talk I'd ever given and I wouldn't have a whole lot of time to prepare because I had other obligations that I had to Take care of during this next few months and you know Terrence Is a good salesperson he convinced me that since I could back out I should go ahead and submit he's sneaky like that So what was the idea? Well When I was a kid, I loved these choose-your-own-adventure books The thing that I really loved the most about them was that you know Not only didn't I know how they the ending was going to turn out But I got to have a say in how we got there and you know for for an eight-year-old This was a huge sense of control and so the idea that I had was for a choose-your-own-adventure talk Now I've never seen anyone try giving a talk like this Of course that could very likely be because it's a horrible idea But I've decided that if there's any place that I can potentially get away with trying something a little bit risky and out There it's a keep ruby weird, right? So what I'd like you to do now. Oh, yeah keep ruby weird So what I'd like you to do next is Bearing in mind that the Wi-Fi may not play nicely you may want to use your phone I This is how it's gonna work go to choices. Ernie.io and our browser whether it be your phone Look it so far current versions of Safari Chrome Firefox iOS Android Even Windows phone and Internet Explorer if you're a freak Those those should all work And then you know the nice thing about writing an app that's gonna be used by developers is you don't have to support IE 8 So that's nice. So I'm watching. Oh, we got 53 people 54 good. Oh, man.  Okay, so far so good Nothing broke yet Okay, I'm just waiting for folks to get connected. So let's see if we can make this work Pick an animal we have in contention cats dogs squirrel monkeys and Venezuelan poodle moths And we give you a moment to vote poodle moth is really getting no love at all All right, so it looks like dogs are gonna win. So we're gonna go with dogs All right, so you get a big picture of a dog and you get one extra bonus picture of a dog for making that choice okay, so Remember these things, you know when I I walk right past them now, but when I was a kid these things loomed in front of me like Genies in so many lamps right I had a if I had a quarter or you know if I could bomb a quarter for my parents I would stand in front of these machines and I would just agonize over over which choking hazard I was gonna purchase And The sticky hands were a constant favorite of mine I think they're one of the all-time best vending machine toys in my opinion Sticky hands getting some love so you've seen these things before right the gel wrist rest so Many years ago. I had one that looked pretty much exactly like this and it had started to fall apart so when I pulled off the cover I made the most amazing discovery you folks and It turns out It turns out that these things are basically made of the same thing as sticky hands are made of so It's just super stretchy and this one is they don't make them like they used to but you know It can it can we used to have fun like flinging this thing at people and like flinging it the wall it would walk down and you know we could pick that you we could pick things up with it and It just made a massive amount said the same same stuff. It's really sticky actually so anyway One day we made the decision we named ours Roderick I don't know why we named it that we just we gave it a name is named Roderick and everybody in the office had fun with him And so we made the decision to see just how far Roderick could stretch and so I grabbed one end and my friend Jeff grabbed the other and You know he just started walking now He got really far too now because I'm about to drop some science on you. I Am very thankful for my gift. So give me just a moment That's not gonna end. Well, okay, see if I can do this one armed because you can't really deliver science without a coat I really don't think all right so in physics There are two kinds of energy primarily One is potential energy This is the kind of energy that you build up whenever you pull back on a slingshot or you know Hypothetically speaking when you stretch a gel wrist rest across the room And then there is kinetic energy right this is energy in motion So when you release the gel wrist rest or the slingshot, there's also in science a little thing called gravity You may have heard of it now at about this time Jeff decided to let go of his end of Roderick I remind you now of where I was holding my end of Roderick Potential energy quickly became kinetic energy and gravity doing what gravity does you might imagine what happened next On the bright side, I have half the surface area for that particular attack vector these days My point with this is that choices have consequences You know, otherwise, what's the point right? If we're gonna make choices that have no consequences then why make them at all so it's a lot It's almost as inescapable as gravity So if our choices are bound to have consequences it makes sense that we would want to have some control and over them Optimize them. So what will we use to try to do that? I am shocked that this thing is not broken yet. This makes me very happy. Oh, it's like neck-and-neck. This is great Okay, it looks like instincts. No, it looks like stop it Alrighty, it's All right, 10 9 8 7 6 5 4 3 2 1. It's instincts. Oh, and it switched to brains right when I clicked it. Oh My gosh, okay, fine. It's brains you folks Okay Okay, so we're gonna use our brains and there's only one problem with that our brains are huge liars really big liars complete liars and in fact a Cognitive psychologist named Peter Wason Conducted a well-known experiment where he presented people with the following sequence of numbers two four six He told everybody that this sequence of numbers followed some sort of a rule and participants were allowed to guess as Many sequences of numbers as they would like and ask whether or not they conform to the rule Now they then had to try to infer the rule that Wason was using Now because we don't have time to get everybody to guess sequences and numbers I'm gonna ask you to pick a sequence that doesn't follow the rule. Okay Wow You're doing very well. Okay, so The the thing is what I just asked you to do is called indirect testing of a hypothesis and it's a lot At something that we often don't do I prompted you to do it just now And so it makes things a little easier But normally we form a hypothesis and then we think of the results we'd expect them to be and that's exactly what happened in Wason's study, you know Participants would find a sequence that satisfied the rule that they had in mind For instance a lot of them would say even numbers or numbers incrementing by two and they would consider continue to test the exact same Hypothesis with every sequence they supplied even once they were told that that was not the rule They'd say stuff. They would get really complex. They would like pi pi plus two pi plus four You know and and for the record the answer was six four two and his rule was just increasing numbers It was much simpler than anybody was thinking Another thing that our brains tend to do you're probably already familiar with the the phrase a little knowledge is a dangerous thing Psychologists call this the Dunning Kruger effect and put simply it means that those who know the least think they know the most because they don't know what they don't know and The interesting thing I think is that it is obvious when you think about it that obviously we can't see our own blind spots That's why they're blind spots, but Side note by the way. I love the title of this article that Dunning wrote. We are all confident idiots That's that's a fantastic That's a fantastic name for an article so Our brains also love a good story and in fact We love them so much that our brains are constantly making up stories that we tell ourselves And we call that the narrative fallacy and it's basically when we assign importance to events even even when there's no Sense to them at all. We just weave a narrative that makes sense That's why it's called the narrative fallacy and you know just because a story is convincing to us doesn't make it right It doesn't make it true. You know it could be true But that's not the same thing as it actually being true Um another thing that our brains do during during World War two We created a branch of government called the applied mathematics panel to do war math the the military called in the statistical research group which was actually part of the applied mathematics panel to help with a Serious problem as it turns out you had about a 50-50 chance of making it back alive if you were flying a bomber during this time And the military knew that what it really needed to do was add more armor to the bombers But it obviously couldn't cover the entire bomber with armor because if it did the thing wouldn't take off They wanted to keep them in the air. That's that's a good principle for for airplanes is that they go into the air so They had records of where the planes that had returned from enemy territory had actually taken the most damage And so over and over again They saw bullet holes accumulating along the wings around the tail gunner and down the center of the body And so they went to the statistical research group and they asked them Please use your war math to help us decide where to put the armor And so as it turns out and you folks are doing very well on this by the way You're really impressive very impressive crowd and I'm not just saying that because I want you to like me So as it turns out We have something called survivorship bias and what what we were actually what everybody else was doing is they were looking at the Plains that came back and deciding well the most bullet holes are in these places This is where we need the armor, but they were neglecting to realize that these planes made it back The ones they have to worry about are the ones that didn't make it back Which probably have holes other places and so the holes showed where the planes could be shot and still survive the flight home But the armor needed to be elsewhere. So none of those places needed armor, but we're not really any better You know we we have heroes. We look to rare success stories in our industry And you know we we strive to emulate their success and you know all the while We miss out we miss out on opportunities to learn from failures both theirs and our own You know even if we were to ask our heroes to candidly share Their failures their honest answers would be tainted by the same narrative fallacy We talked about just moments ago, you know They like we are just as likely to overemphasize reasons for their results And and to downplay the roles of things outside of their control And this is just a small selection of some of the ways that our brains can't be trusted and so When we put it that way it really We sound pretty hopeless, right So All kinds of factors conspire to influence our choices and our outcomes Wow, this this one's actually an easier one to call All right, let's just go with internal All right, I can get behind that. Uh, we clearly can't trust ourselves to always make the best choices So in my younger years, I went on a few hay rides You're familiar with these, yeah You know folks think it's a great idea to load a bunch of people into the back of a trailer filled with hay Now as somebody who's had a long time allergy sufferings I'm not really this this perplexes me as to why anybody thinks this is a good idea Still I went on a few and you know on the bright side There's always a bonfire And you get to have hot chocolate and marshmallows and hot dogs and stuff. So that's cool Um, so the hay rides over We're at the bonfire and I'm standing off to one side. I'm minding my own business And uh, to my surprise two very attractive young ladies came by to chat with me And this really confused me because I was nowhere near as handsome as the two young men in this purchase stock photo here um This was me Eat your hearts out so naturally Naturally, I panic I actually start trying to think, you know I think What would a cool person do and I'm this is literally what's going through my mind I'm thinking what would a cool person do and so the only thing I could really think of that I'd seen cool people do was You know, they they kind of lean against the wall and they prop their leg out like this. Yeah, I don't care You know, I'm totally chill. You know, there was a problem with this plan You know as it turns out there was a basement window that was directly behind me And so the spot I decided to prop my leg up on actually sent shards of glass Showering down on to uh into a basement kitchen where two elderly ladies were making hot chocolate for us um So that went very well So I want to talk about something a little different um relating to internal factors um I have I have regularly Assumed that the stuff that's obvious to me is obvious to everyone else And for a long time Yeah, this is great, right? Somebody actually felt the need to put a warning label on a bag of peanuts that says it contains peanuts um For a long time this this kept me from sharing code For and it definitely kept me from doing anything regarding speaking So for at least two years, I've been filling out those stupid Uh yearly review uh worksheets, you know the ones where where it's like what are your goals for the next year? And then later they'll review and see if you hit them and I had regularly put public speaking on those But I I hadn't really taken any steps to do it So on january 1st 2013, I made a resolution and I posted it on my site to keep me accountable I picked the entire internet uh as my accountability group because I suck at boundaries and So a few weeks later I had two conference speaking opportunities booked and it is two This is like a few weeks after I said that I was going to try it and my first ever speaking opportunity was in texas actually a big ruby Uh a few years ago, and I'm going to be forever grateful to the organizers of that conference for giving me a shot But that same year I got to go to to mosco and speak And I got to keynote ruby conf which I had privately set as a as a five-year goal I hadn't really told anybody And then this year just uh just a couple of months ago. I got to go to beautiful barcelona and speak And more importantly than any of these things that happened from that result um, I actually got to make so many friends during the past few years that Uh, they've enriched my life so much. I'm so thankful for everybody in this in this room that I can count as a friend I'm just so thankful for you all and I think that it's really interesting because All of this was just because I chose to shut down that little voice inside of me that was worried about what other people would think so I don't ever claim to be the smartest guy in the room And uh, it turned out that the hayride and the speaking thing actually had a few things in common after all They weren't completely different. Um, I didn't recognize this until a lot later But nearly every time I've opted to be inauthentic Because of what someone else might think I've missed out somehow And you know look I want to be very clear. I am not you. I this is not a prescription for What you should do But what i'm saying is that the patterns you might see in your life are going to be different But uh, I can promise you that if you spend some time You know, you're going to spend your entire life stuck with yourself like it or not So if you spend some time figuring out these kinds of patterns, it's going to be worthwhile So Which one are we? So we're agents Now when we say we're agents, we don't mean we're like Horatio Cain though. I think we can all agree that would be awesome Um, what I mean is agency We're talking about agency This is the power that you have to shape the world around you in ways that are large sometimes and sometimes small An agent is something you are and with that I would like to uh Point out that that's on your bingo car that you are an agent and uh Yeah Kragoh, I think is how you pronounce this I have Kragoh now I don't have time to collect my hug from Aaron. So unfortunately, I'm gonna have to put that on hold until later Um, so I believe that as a member of the human race You're an agent your choices are shaping the world around you And the interesting thing is that you know, we exert our agency whether we want to or not it just happens sometimes It's involuntary, but we're still shaping the world Now if we contrast that with a victim, I want to be very clear what I mean when I say victim We are not talking about people who have actually been victimized There are people that have actually been victimized and this is not what we mean We're talking about a victim mentality and this is a really important takeaway While an agent is something you are Victim mentality is something you learn And I'd like to think that if it's learned it can be unlearned There are plenty of situations where maybe even you really are victimized, but you can choose not to let the victim mentality take over I have been volunteering as a counselor for about seven years now And I've dealt with folks in some pretty desperate situations That I would not wish on anybody And some who are pretty far towards the other direction on the spectrum And in my experience, there's actually very little correlation between the people who are victims and the people who exhibit victim mentality I've gotten pretty good at guessing when this is going to become an issue though that we're going to have to deal with my counsel folks And you folks seem to be pretty good at it too All of these things can be indicators that there's a victim mentality involved But by and large people who feel powerless are going to usually resort to passive aggression They go to passive aggressive mode because because they have difficulty acknowledging their anger directly and because of the way they feel about themselves So I'd like to think though that there are situations even that we generally genuinely can't control You know things happen life happens But we should be looking for things that we can or even did control Even when you can't control the outcome You can control how you react to it and this is something that sounds really trite But it's something I have to constantly remind myself of because that might be the only control that we have in some situations The point I'm trying to make is that you're an agent and agents choose I'm going to make a guess that at least a few of you recognize these two images They're the symbols of the alliance and horde factions in blizzards mmo world of warcraft Years ago. I played world of warcraft like I played a lot of world of warcraft Oh For me This is a screenshot of a friend in me Posing with king magne bronze beard. He's the the dwarven king We were the only two dwarven grand marshals on the argent don server. If you know what any of that meant, we should talk later So I swear there was a point to this we'll come back to it later If we're agents we are literally always making choices We're making them Whether we're conscious or not and as rush told us even if we choose not to decide we still have made a choice So hang on. I have something I need to do All right, we'll see how this goes. Have fun with this. It's actually working. Oh man. This was the thing I thought was going to crash So The problem is we make so many choices without realizing it um In my world of warcraft story that I promise I would get back to Grand marshal was a was a a rank that you had to attain by playing a whole lot of pvp or player versus player activity um In pvp You had to at the the very last ranks as you were grinding for grand marshal You had to put probably at least eight hours a day into the game now. I had a regular day job I uh I still put my eight hours in to get grand marshal. I was operating on about three hours of sleep for uh select star from music I love you folks. Um So So distractions Anyway, okay So I'm like, okay, uh, I need to be grand marshal. I got really invested in this grand marshal thing I'm putting in eight hours a day on that. I'm putting in at least eight hours a day on my job I am trying to have some family life. I'm trying to you know, like take care of things like feeding myself, which I hear is important and so All of this I'm putting in all this effort that I'm putting in I'm getting no sleep And I go to a new job. I start my new job And I go into a meeting one day and I almost fall asleep in front of my brand new boss because I had put Eight hours in the night before and I was one day away from getting my grand marshal ship um likewise Likewise The There's a reason this is up for so long by the way and the point is um In this particular story, right? I didn't realize at the time But I was using I was using making a choice to to emphasize these accomplishments Because I wasn't feeling like I was making much accomplishment in the rest of my life Um at the time I was in a failing marriage Um, I was in a very unhappy situation in a dead-end job as far as work went I was um, probably borderline depressed at that point and I was putting in this time because at least I felt like I had some control I was making that choice at the time unconsciously. I hadn't reflected on it at that point I didn't understand what was going on, but that's what I needed Um, you know likewise we work all day sometimes and we run out of time And you know, we think we underestimated how much time we had but we didn't We chose to be distracted Guess what? We probably got up in the morning and we got online and we got on twitter and checked reddit and fired up irc And slack and all of these possible things and then we look at the end of the day And we realized well, there were all of these things that were so Incredibly distracting to us and we think they just happened, but we chose we opted in we turned on that fire hose Look, it's good to make good choices But it's even better to understand why you make them and it's even better than that to start noticing the choices that you didn't even realize you were making And you know look even good choices, uh, might not be the best ones. For instance, let's say, you know, we're talking hypothetically here Maybe you've got writer's block for a talk that you're working on and You want to take the time to build a fully functional chat application for a single slide Show on your screen Um, all right anybody have anything last to say because this is going away The helicopter will stand by us forever all right so You are fun okay so This uh, this by the way is yak beaver. I found him yesterday online um This is about this is about intentionality. We have to choose our choices. It sounds very meta, right? Be conscious about the choices that you're making Like I had no idea how this was going to turn out when I told terence. Yes As of three days ago I was building this very slide you're looking at right now and stressing out over, you know Whether I had chosen the right content to include And I didn't even know how it was going to turn out when I got up here on stage In front of you because there are a lot of slides in this talk that you never saw Because of the choices that we made along the way Did we choose wisely? Well, that's the thing the the real adventure is in not knowing how the story ends, isn't it? Thank you


The Bemidji Carnegie Library is continuing its fundraising efforts with a community pint night. The fundraiser is to raise awareness and funds for the Carnegie Library project, revitalize and restore the historic building. One dollar from all beverages will go toward to save the Carnegie fund. As of March 2017, more than $1.3 million has been raised. That'll just garner a little bit more funds that we can use for this project. And then at the pint night tomorrow night at Bemidji Brew, we will have the drawing at 6.30 p.m. You don't need to be present to win. I am still selling tickets here at City Hall all day tomorrow. The pint night will be held at Bemidji Brewing Wednesday from 5 until 7 p.m. If you've enjoyed this segment of Lakeland News, please consider making a tax-deductible contribution to Lakeland Public Television.


Hello friends welcome to the session I am Malka. I am going to help you find dy by dx in the following that is x square plus xy plus y square equal to 100. So let's start with the solution. Our given equation is x square plus xy plus y square equal to 100. Now differentiate both sides with respect to x we get dy dx of x square plus dy dx of xy plus dy dx of y square equal to dy dx of 100. This is equal to dy dx of x square is 2x plus we apply the product rule in dy dx of xy which is first term into derivative of the second term that is dy dx of y plus second term into derivative of first term which is dy dx of x plus dy dx of y square is 2y into dy by dx which is equal to 0 since we all know that derivative of a constant is 0. So this can be written as 2x plus x into dy by dx plus y into 1 since derivative of x with respect to x is 1 plus 2y into dy by dx equal to 0. Now this can be written as 2x plus x into dy by dx plus y plus 2y into dy by dx equal to 0. So this is equal to now we will take dy by dx common and this will give us x plus 2y equal to minus 2x minus y therefore dy by dx equal to minus common 2x plus y upon x plus 2y therefore dy by dx equal to minus common 2x plus y upon x plus 2y which is a required solution hope you understood it I will enjoy the session goodbye and take care.


Hi, welcome to Physiology Open. For understanding the functions of glucocorticoids or cortisol which is the major glucocorticoid in body, you should realize that glucocorticoids are the hormones whose concentration rises in its stress and these hormones do all things to help the body deal with its stress. You will be able to correlate better especially if you take an example of an animal. So suppose when an animal is injured, which is obviously a state of stress, what are the things which should happen in the body? Since during this time, the animal will not be in a state to search or hunt for its food, its blood glucose levels should be maintained, isn't it? Especially for the neurons, since other tissues can even use fats and amino acids at fuel. Secondly, it should help in repair of the injured area. So with injury there will be inflammation, so it should keep the immune system in check so that it does not overdo its job and spoil everything. So how does it carry out all these functions? For maintaining blood glucose levels, glucocorticoids should stimulate metabolic reactions which release glucose in blood. Simultaneously, they should shift the metabolic systems of tissues other than neurons from utilization of glucose for energy to utilization of fatty acids and amino acids as fuel. This is known as glucose-pairing effect of corticosteroids, that is they are sparing glucose for neurons since it is the only fuel which they use. So in factual terms, glucocorticoids increase the gluconeogenesis in liver to provide a regular supply of glucose. This is the utilization of glucose by skeletal muscles by preventing its uptake. This is an anti-insulin action, since insulin facilitates glucose uptake by muscles. Then glucocorticoids increase proteolysis, proteolysis means a breakdown of proteins. This releases amino acids and these amino acids can be used for gluconeogenesis. Also they can be used for repair, say in case of injury. So basically synthesis of proteins is inhibited and its breakdown takes place. In short, you cannot build your muscles if you are under stress and your glucocorticoids are consistently high. Glucocorticoids also increase lipolysis in a deposed tissue causing breakdown of triglycerides and thus releasing free fatty acids and glycerol. Free fatty acids are used as fuel by tissues while glycerol is used for gluconeogenesis. Now let's come to next function. For checking the immune system, glucocorticoids exert some anti-inflammatory action. Basically they act on almost every step of inflammation. So this diagram in brief shows some of the steps of immune response. Glucocorticoids reduce inflammation by stabilizing the membrane of lysosomes. The contents of lysosomes are pro-inflammatory, so when lysosomes release its contents it causes increased inflammation. So the stabilization of the membrane helps in restricting inflammation. Then they decrease the expression of addition molecules and endothelial cells, thus decreasing the recruitment of WVCs to the site of inflammation. Then they decrease the release of cytokines by WVCs, which are responsible for further recruitment and activation of WVCs. Now since many cytokines lead to proliferation of fibroblasts which synthesize collagen, this also prevents excess car formation. And glucocorticoids also inhibit production of antibodies by bilemphocytes. Not only that, they can also induce apoptosis of WVCs. Then in various immune cells, arachidonic acid is released from membrane, from which prostaglandins are synthesized in presence of cyclooxygenase enzyme. Now these prostaglandins activate many steps in inflammation. This increases the synthesis of lipocortin while inhibits the synthesis of cyclooxygenase enzyme. This lipocortin actually inhibits the enzyme phospholipase A2, which is the one which actually releases arachidonic acid from the membrane. So due to increased synthesis of lipocortin, less arachidonic acid is released and due to inhibition of cyclooxygenase enzyme, less prostaglandins are produced from whatever arachidonic acid is there. So this again limits the inflammation. In fact, for the check on immune system, a negative feedback loop operates. WVCs themselves secrete ACTH, which increases cortisol, that is glucocorticoids. Also the cytokines, which are released by WVCs, act on hypothylamic pituitary axis increasing the release of cortisol. And the release cortisol in turn inhibits the actions of WVCs, so this is a negative feedback loop, isn't it? Apart from this, glucocorticoids have many permissive actions also, that is presence of glucocorticoids is needed for the action of other hormones like catecholamines and glucagon. The release of free fatty acid is the major action of catecholamines for which glucocorticoids are required. Also in acute stress, they are essential to maintain blood pressure. Catecholamines cause vasoconstriction for which glucocorticoids are required. So these are the functions of glucocorticoids in a nutshell. Well, hopefully you have understood the fundamentals of functions of glucocorticoids. Thanks for watching the video, if you liked it, do like and share the video and don't forget to subscribe to the channel Physiology Open, thank you.


Hi and welcome to the session. Let's work out the following question. The question says solve for x x-1 divided by x-2 plus x-3 divided by x-4 is equal to 3 1 by 3 where x is not equal to 2 or 4 So let us start with the solution to this question We have x-1 divided by x-2 plus x-3 divided by x-4 is equal to 3 1 by 3 This implies x-1 into x-4 plus x-3 into x-2 divided by x-2 into x-4 is equal to 10 by 3 This implies x square minus 4x minus x plus 4 plus x square minus 2x minus 3x plus 6 divided by x minus 2 into x minus 4 is equal to 10 divided by 3 This implies x square minus 5x plus 4 plus x square minus 5x plus 6 divided by x minus 2 into x minus 4 Let us expand this one We have x square minus 6x plus 8 is equal to 10 divided by 3 this implies 2x square minus 10x plus 10 divided by x square minus 6x plus 8 is equal to 10 divided by 3 This implies 2 into x square minus 5x plus 5 divided by x square minus 6x plus 8 is equal to 10 by 3 This implies x square minus 5x plus 5 divided by x square minus 6x plus 8 is equal to 5 by 3 Which further implies that 3 into x square minus 5x plus 5 is Equal to 5 into x square minus 6x plus 8 This implies 3x square minus 15x plus 15 is equal to 5x square minus 30x plus 14 this implies 5x square minus 3x square minus 30x plus 15x Plus 40 minus 15 is equal to 0 This implies 2x square minus 15x plus 25 is equal to 0 This implies 2x square minus 10x minus 5x plus 25 is equal to 0 This implies 2x into x minus 5 minus 5 into x minus 5 is equal to 0 This implies x minus 5 into 2x minus 5 is equal to 0 This implies that either x minus 5 equals to 0 or 2x minus 5 equals to 0 This implies x is equal to 5 or x is equal to 5 by 2 So our answer to this question is that either x is equal to 5 or x is equal to 5 by 2 So I hope that you understood the solution and enjoyed the session. Have a good day


From there we move into the design phase and in design this is where you really start to get the creative power of thinking about how we can solve the user's problems and there might be many ways to do that so coming up with ideas around how we Solve the user's problem in different ways and getting to that ideal design at the end of the day And we'll talk here about idea generation and how you do idea generation as well as the tool of wire framing Also, then you move into prototyping and we'll talk about different levels of prototypes and the value of starting small and growing momentum as you iterate through this process and then testing Getting incremental tests as you move along not just testing once you've built the whole thing And so how do you test? Internally and then with users as well so that you can validate that your product or your design ideas are working And of course this is an iterative process and we will address how you Start at the beginning and then how you can kind of grow and refine as you move along the iterations So starting off with concept This is a part of the process where once again you're really trying to define what is the purpose of The product that I'm building and so if everybody on the team doesn't understand some of the basic questions About what value is it's going to bring to our users? How will their life be improved? How is this different from other solutions out there on the market? It's very likely that you're going to create a product or a solution at the end of the day That isn't really that compelling to the market So taking the time to really understand Why you're building what you're building and making sure the whole team understands not just the product owner Can really make sure that everybody's driving towards that same vision The next step of this is understanding who your users are so In user experience design we do a lot of user research We'll go out and actually sit next to users watching them use what they they do today kind of identifying trouble points Seeing them in their context. So you start to see things like Okay, you know this user is using my product while also answering the phone and getting interrupted by five people and Whatever else is going on within their context? And so really doing research understanding who your users are their environment and their needs can help drive Design decisions that you make later on so for that very interrupted user You might need to design the system in a way that they can Leave their task in the middle of the task come back and still have a clear status of what's going on Because they've completely forgotten where they are in the steps And so in user experience design we call this process user research and then out of user research We typically create something called personas and personas are exemplar users. These are something that the development and design teams can use together to Discuss our users in a common format. So also part moving into the definition phase We really encourage all teams to use user stories This is very common in agile development And so most people who are doing agile development are very familiar with this format But even if you aren't using agile development the use of user stories can be very helpful so that you start to think about your requirements in users terms So why does a user actually? Want this feature what's the reason behind it and which user wants this feature? Maybe all of your user types need this feature Maybe only one of them do but having that discussion and truly understanding How it's going to be used at the end of the day can really help drive the design and what you? implement and You know I caution you here because so many teams Rush through the step you want to start building and I get it You know we're all makers we want to build it But if you don't spend the time really forcing the teams to get to the level of detail that's needed here It means that you're not all on the same page, and you're going to kind of end up with a disparate implementation Also in the definition phase another tool that we use in user experience design is user flows And once again, this is a step that a lot of people skip past And go right to design But the value here is that by really thinking about your user flows You're going to start identifying some of those areas where you might have touch points between systems either internally between your team or Possibly even externally between other teams other systems websites that pass off to you Could be a variety of things and it really helps you understand the full path that the user is going to take and Communicate with other teams potentially about what you what you need from them and what they need from you in a more Consistent fashion and not at the end of the day is going to produce a better experience for your users Moving into the design phase This is the fun part from my perspective, right? This is what what we love doing as designers, but So this is where you where you start off with divergent thinking you really how can we create Something that is different that is unique that is Maybe outside of the box. What is something that we could actually maybe use even as a? Competitive, you know Improvement upon what's in the industry so far so really think outside of the box here come up with lots of different designs get other people Adding in their designs if you're creating something just for your team Maybe get other team members who aren't thinking about it also creating some designs because through the divergent process That's where you're really going to get some new ideas and change the way that you think about the problem But this has to be time-bound. We can't just go create You know all these different options forever at some point we have to decide on something and move forward so It needs to be time-bound and at some point you're going to start converging On a couple of ideas and it doesn't mean that some of the ideas that you're not converging on are not good And you might come back to those in the long run, but you want to choose a few ideas that you think are useful and Might really be something that you can implement and Get could use our feedback on and start moving towards the implementation of those So a tool that we use in the design process is called a wireframe Wireframes come in a lot of fidelities, so they can be very low fidelity They can even be you know sketches on paper sketches on napkin who cares Or they can go all the way up to being extremely high fidelity where it's actually an image You know pixel perfect sort of image of what the system is going to look like when it's implemented We highly encourage you to start very low fidelity at the beginning and only work towards higher fidelity as you're moving along those iterations and By starting with low fidelity what it means is that you're getting the basics you're getting your basic ideas out there without getting caught up on the details And you can start testing those basic ideas and validating them before you commit too much time into it So then you start moving into the prototyping phase Once again, you want to you want to take this in an iterative manner How can you really start thinking about Implementing this in the minimal way possible and that actually might mean no code to start with and actually encourage it to mean No code to start with a best practice is actually to create something that You can put together in a day or less with no code to test with users first So here's an example that we did actually with the UX team We tested the Red Hat storage dashboard at the Red Hat Summit in Boston last year So we had gone through design iterations of the individual Graphs and metrics that you see here. So we are fairly confident about those which is why they're pretty high fidelity We had already iterated and gotten user feedback on the graphs themselves What we weren't confident about is how storage users wanted these assembled onto their dashboard in a way that was Most compelling to them as users of the storage product so we printed these all out and We allowed users to come up and actually to start moving them around and talking to us about them And so this was no code It was very simple to put together and we got a lot of very interactive good feedback from users that really impacted our design at the end Of the day. Sorry, that's been crackling the whole time, huh? All right As you go through the iterations once again, you'll you'll start increasing the fidelity increasing the code and working towards full UI development and Serena will be talking to you a lot more about this phase So I'm gonna continue on and then testing this is This is the bread and butter right here The more testing you can do the more feedback that you can get from users the better off you're gonna be So there's two Levels of testing that I wanted to point out one level of testing is internal. It's really just saying all right We built something did it meet the criteria that we set out at the beginning Does it actually meet that user story doesn't meet the user flow we defined? So make sure that you actually implemented what you talked about at the very beginning So that's step one But as you can see here a lot of times this actually falls apart especially in those handoffs Between different systems or different Teams and so it's really important to make sure that we we do End-to-end test this make sure it meets the user's flows as we expect it to meet them if you Get that basic check then you can move on to usability testing with usability testing there is Once again a variety of ways of doing this you can do it from you know Taking your design down to the cube of somebody down the hall and just getting feedback that way Or you can go for a full-out usability testing that user experience professionals do And That's where we you know We'll do The the full-out way of doing it is we have an actual usability lab We bring in users we watch what they're doing. We record what they're doing. There's it's quite timely What we do most often in the uxd team these days is actually remote usability testing and This allows us access to a very wide audience, which is great And you can do this as well with your systems on your own So you just set up a WebEx or webinar type Set up you share your design you hand the mouse access over to your user You give them a few tasks to try out and see what happens see how well they do Yeah, okay You guys hear me, okay? Okay, great So how does ux solve problems? So I guess the first thing that I want to make sure everybody understands is UX and UI are two different things, right? So UX is the user experience. So what does the user? How do they feel? How do they encounter that the UI as they go through where the UI is actually the product itself? UX is a number of different disciplines. It includes you know content strategy information architecture user research interaction design visual design and usability And then if we wanted to break down interaction design a little bit more The pieces that we focus on a lot, especially within pattern flyer consistency giving relevant instructions to what you're doing Making sure the visuals are appealing and make sense you know color is used in there the right circumstance at the right time and Also another one that's biggest customization options, right? So users always like to customize their own environment But where does pattern fly focus for the most part we focus on visual design interaction design and user research So I'm going to go through that a little bit But before I do I'm just curious if you guys but can show your hands How many of you know have heard about pattern fly before? Wow, okay How many of you guys are interaction designers Okay, and Developers Okay, excellent So, you know, how do we go from either an existing product that might not look so Currents or from a wire low fidelity wire frame to something more that's like on the right hand side And we're promoting that you do that with pattern fly so pattern flies an open source project So we started it in the red hat uxd team Probably in about 2013 but in 2014 was the first time that we Put something in get hub that was accessible fire from everybody It promotes design commonality and an improved user experience across enter enterprise IT products Our color scheme is essentially tested and built for that and As well as a lot of the newer components that we're putting inside of our pattern library Lately and if if you guys are familiar with it, you'll see in the last three to six months We've been adding a lot of dashboard components, etc. And that's going to be continuing in the future Currently we use it at red hat to unify the styling and behavior of all of our products www.patternfly.org is our URL. I'm going to actually show you that a little bit later on But first wanted to just talk about the goal of pattern fly Again promotes consistency and usability it reduces cost and time to market And the reason we say this is because there is you know proven design patterns in there some of them More complex than others and often times many of them are also usability tested so from a interaction design perspective You can go find something there. It'll explain why to use it when to use it But then you'll also have for a coder You can go and find the reference markup and pull that right into your application if you'd like to put one of those Design patterns into your app it improves consistency within your own application if you're using the same component Also for it if you're using pattern fly within a Portfolio of products obviously it will also improve consistency and it increases usability It also allows the user that the learnability is much quicker because it's consistent So as I mentioned earlier or asked a question about designers versus developers The reason I asked is because we have two distinct areas One we have a pattern library with usage guidelines like I mentioned We also have you know color palettes a set of icons We we include font awesome icons, but we also have some custom icons that are just for pattern fly Also talk about typography and where to use what styles when We also give some guidance on terminology and wording as far as You know what cut what sense and if you should use sentence style capitalization or that type of thing in different areas of the UI And then as I mentioned for developers there's reference markup and the angular JS directives So we have two flavors of pattern fly. We have a base pattern fly Which I'm going to talk more extensively about but then we also have an angular version which is a different flavor So what is base pattern fly and what does it include? Essentially built on top of bootstrap and how many I'm assuming how many of you guys know bootstrap about bootstrap? Okay, great We say it's pattern flies bootstrap plus extra love the extra love is supposed to be you know UX Involvement usability testing as well as we have some additional components. So we've got a number of bootstrap Extras that have been put on as well as some jQuery Components we also as I mentioned included font awesome, and then we also have lately included C3 and D3 charts I think we did that in the fall of 2015 and those all have you know a pattern fly styling built on top of them As I mentioned we also have the angular JS And there's a different repo for that angular JS was actually created as grassroots effort effort within another area of Red Hat and then in the last six months our group has started to increase Contributions to that as well if anybody's interested on the design architect of pattern fly and there's a Leslie Hinson Who's also at Red Hats product owner? Where are the ones who do you know requirements gathering dated Leslie does day-to-day management? I'm going to talk about the process a little bit as we are using Jira Our board is you know completely public anybody can go there and see what we've got in the pipeline We have two-week sprints, so we are currently publishing every two weeks a new release And our stories are very you know they're based on coming up with conceptual designs first We blog about what we're talking about Building we look for the community to give us feedback Then we create a design and we have the usage guidelines posted on the site then the next sprint We create Marfan's markup, and then typically the next sprint is angular So you know we're we're kind of in the same kind of cadence As far as getting things out incrementally This is pretty much already talked about so yeah for the pattern library, which I'm going to show you a little bit It's so I'll show you exactly where these things exist on the site. I Just wanted to show you a couple of the different components I had mentioned some of the charting components we have so we Catherine it actually showed you the Testing that we had done at the red hat summit and what we were doing were a lot of our products were using different Dashboards, and we were trying to look for common Common dashboard cards to use within the application, so we've come up with a couple of them So you know the one on the top is just a trend card But it has the ability especially in the angular implementation has the ability to change some of the Location of the percentage or if you want to use a an actual value versus a percentage The one on the lower the lower left is what we call aggregate status cards It's essentially the ability to give you a count of how many objects are inside of your Environment and then maybe be able to show you either errors or object status of certain a subset of those And then the one on the right we call a utilization trend card Because it's showing you the current utilization the bar or the arc is colored based on thresholds So hypothetically you would set a warning and an error threshold So if it's has not met a threshold yet It's green once it's met a warning threshold it's orange and then goes to red if you hit the error and then it also has an Associated trend line for the like the last 30 days or whatever you choose to have And one of the other things I just wanted to focus on was the different view types So currently we are supporting tables We call this a list view and then we also have card views coming up soon So there's there's some of our various patterns and the list view has been like really It's been getting a lot of attention actually in the community lady lately asking as our reference markup is just getting released this week So All right, so I'm going to give a demo, but it's in it's recorded Good thing I recorded it Yeah, we had internet challenges, but I would have had worse challenges with my Mac, so This one sorry there you go. Thank you. All right, so this is I'm gonna This is essentially what I'm what I'm doing is using bower to install pattern fly created a new directory It installs pattern fly And it was a little slow because I was doing it outside But once it installs pattern fly what I'm going to show you is just how quickly it It is to actually bring something in and build a quick app So I'm just showing you on the left hand side. There's a directory called our components on the right hand side I'm touching an index dot HTML, and I'm using vi so excuse me for that I Bring up the index dot HTML I go into bower components because there is a Underneath bower components pattern fly. There's a Quick start file and inside that quick start file It tells you what you need to include into your HTML to just in so that you can use pattern fly I'm gonna grab that in a minute Now I'm pulling everything in just because I didn't have time to pull out what I didn't need But I'm just pulling everything in and then what I'm going to do is bring up the pattern fly website And once you go into pattern fly website, you can go into the pattern library And within a lot of the elements in the pattern library. There's something that's called reference markup Our reference implementation. I forgot what we call it right now. Yeah reference markup You can open that up you have the associated code So what I'm going to do is bring in those aggregate status cards Right into my HTML and then I'm going to bring up the browser Bring up that index dot HTML in there Oh, I typed in one line and save it and then bring it up on their left And you can see how quick it is to bring something in So there we go. There's the aggregate status cards So then I decided to go back over and pattern fly look at the utilization trend cards Where there's a row or a strip of three of them. You'll see below Actually, that's the one so I choose to go down to the three And I pull out that reference markup Copy it again So And once we copy it you'll see the the result so again like this this is great for two reasons in my opinion and one is you know For the code, it's great, but it's also good for prototyping right so you can say take something that you see that exists inside of Pattern fly and build something really quickly that might not have the back end working But you can actually visually see it and see what it looks like And even get some interaction with it. So that's actually the end. I was going to try to do one more thing, but I I'm not going to do that What I'm going to do quickly is just show you pattern fly itself and just go through some quick areas Ten more Okay, so Actually, I'm also going to say this is this is the site design that's currently out there We're also working on a pretty big site redesign That's going to be much more usable in the future and I think people are going to like it more It's going to be more focused on Kind of delivering things for the designer designer and developers separately where now right now It's a little bit more convoluted So if you go into I'm going to show you the widgets area first so in the widgets area is everything that we have that's either a bootstrap or jQuery or C3 and D3 charts so you can see anything that we've done here and have the code associated with that So so you can get the reference markup for forms there and in the patterns area This is more of the these are more patterns that we've created in design specifically for specific Use cases I would say so we've got different types of things for The dashboard we also have different types of charts. We have something called an empty state So if you you know if you have a table that when you start up The table of users for instance there are none that exists So we have a pattern that it would would show that you could use that will say why there's no users and maybe allow you to Hook up your main action to be able to create a user We have things like inline notifications toast notifications All kinds of things like this so again with all associated reference markup that you can grab and Then the other thing is we do have the angular Currently we have our angular documentation that's on a different URL, but there's also sample code for the angular there as well Now Okay, thanks So we do have monthly pattern fly meetings So if anybody's interested in attending we give a demo of what's happened in the last four weeks We talk about what's coming up in the next sprints And people can give requirements or even talk about being able to contribute. We'd love that And that's right now is the end of a presentation wondering if anybody has questions Yeah, we don't not at this point I'm sorry Yeah, do we have any plans for a wireframe tool that with drag and drop that would be Integrated essentially with pattern fly is what you're asking and no we don't we do have Some templates for some of our low fidelity wireframe tools that we currently use It's I think that's an interesting thing to say we could we definitely could Look at doing that is something that we have started building in some components for Our team internally either for low fidelity and for high fidelity for Photoshop So I think over time we could look at kind of putting those out through pattern fly right now They're not I would say they're probably not organized well enough To share but I think we could get there. So that's great. Yeah, because we've done some with balsamic But we don't have anything Thank you Well, there's styles that are There's styles that are in a subdirectory right that you're referencing and some through some of that code And those are automatically updated etc with each release If you're a lot of what pattern fly has Some of its styling on top of existing bootstrap and jQuery components But others are like built-in components that we build in from scratch So it depends on which ones you're talking about really, right? Well, so and in the angular you would get those automatically so we like I said, we have two different flavors So an angular you'd be using the directive which is all-encompassing But based on what you're picking in base pattern fly it might differ So on the part of the red hat that I concentrate on a lot, we do have a lot of teams who use Google tool kit and other other frameworks as well and The the short answer is we don't have something for installed applications. We've concentrated on web applications We think that's where the most power is in the future for applications to live But there are a lot of teams who have taken the pattern fly styles and they can take HTML CSS From those and basically kind of refactor them for Google tool kit or other frameworks We have not brought That work back into pattern fly at this point because we haven't done that in a standard way Each of the teams have kind of done that uniquely based on how they've implemented it And I think that's one of the challenges is there's so many tool kits out there that it's hard to standardize How we would do that and and that being said though I mean it is open source and we you know, we had an angular version created So if people are interested in the community to contribute into something like that, you know And there's enough interest I think we'd be interested in taking contributes contributions like that as well So I think we have two minutes left I just want to say that we have a bunch of t-shirts and stickers if you guys want to grab them on the way out And I didn't know if there's any last question I think yeah, it's it's easier, but It's a it's different context, right? I mean this is I think base pattern fly is easier for For many applications to pull in if you're using angular, I think You should take a look at angular pattern fly Because it's more componentized Thank you very much It's so nice to see you I I Have your large Extra large Great job Connecting If you have room on your left or your right please squeeze into the middle of the room So we can pack as many people as possible into the room So we don't want any back-end seats here Please make new friends and