I don't know if you guys know what next door is, but next door is an app where you can sort of like log in to Basically like your neighborhood.  I would need them back by tomorrow evening. Yes I am too anxious to ask my neighbors to do anything At all and I really like my neighbors a lot. I really like my neighbors a lot I did actually when I first moved in here I did actually ask my neighbor for something and I Really took a lot for me to muster the courage because I didn't have a ratchet set and I was like I needed to mount a TV and I needed a ratchet set and I I Did I I don't know why I didn't just go buy one, but I was like oh I bet my neighbor has one That I can just borrow because I don't really And I mustered up the courage and I and I did it Sick think I got you'd stroke and was left abandoned with the graduation thing Let's do top of this month my granny died a year and a half ago I'm so happy. She had a Facebook so I can look back finally at her photo albums. Here's my favorite guys I would love to bring home Oh It's so good before calculators people used in pencil Van Morrison is playing Liverpool fill in feb who wants to go our mat used to our mat used to sing Brown-eyed girl to me even though I have green eyes lol I'm so sorry. What happened? That's the spirit la la la you my liver complications So good, that's so good. I do love that sometimes old people on social media Don't understand that Responding to a public post if you respond to it.  Alexandra started Doing a search for things about virginity and RV life I Can't say her name fully her shortened name I'm on a roll this afternoon got a spam color that wasn't a robo collar some poor guy introduced himself I wanted to talk to me about my automobile insurance rates the conversation went something like this. Good evening, sir My name is my son just died Why why do you keep talking about dead people on public posts? Just don't do call them on my local news page The post was about a coach preying on the high school football field. We never hear about your wife anymore Very insightful either. Oh No sleep tonight then Is I'm confused about what this is about it's hot in your room or It's hot in your room Maybe it's your birthday, you know all the best today. I'll be thinking if you Please My grandson is supposed to be having a job interview is he there I feel as we hope your grandson did well He didn't go. He was busy catching those pokey bugs on this phone very upset with him Since July It's good Foldable Bluetooth keyboard is this item still available. Yeah, it's got your message. Does it work? Yeah, I no longer have a practical use for it. Is it loud? No, it's a membrane keyboard Oh, never mind. You want a loud keyboard? Why you have one and how much all I have is 20. Is it Bluetooth? Yes, it's a Bluetooth keyboard How much? Oh my god It's said there twenty dollars Is it wireless? Can you send me a pic? It's twenty dollars. Yes, it's wireless Does it work with phone tablets and computers? The pics are in the item gallery What is the gray one the same keyboard folded? Do you have to use the keyboard? Can you use it as a speaker? It's just a keyboard. Never mind. I'm looking for a Bluetooth speaker It's so good I love that. It's honestly amazing how much more I enjoy doing the dishes when I have two essays to do on Monday And if you don't do the essays, you may be able to make a career out of it. Love you. Hell. Yeah, grandma.  Do you want this bowl? That's such a funny way to ask someone a question That's so funny Six year old co-worker has been texting me every day wherever you are. Good morning. Good morning. Good morning Good morning. Good morning.  No grandma grandma. Please Oh, no It's great sadness in my heart that my 49 year old sunshade died this morning. That is all laughing emojis Why They should break an age barrier for These kind of posts where facebook locks you out of it as soon as you hit like 55 Oh, no, oh no two beds one bath house. Good evening. Is this available? Yes, it is. Please leave me alone We are sleeping no more god Please thanks appreciate you contacted me. I know I love I no longer interested. Please stop contacting me now I will stop attorney general if you do not stop I will contact attorney general if you do not stop It's good facebook. Please put pictures from christmas on here Grandma, what are you talking about? I'm trying to put the pictures from christmas on the facebook But it won't work.  Please put pictures from christmas on here.  That's the other it's fine. You will get wet. I've got jackets. I called mister uber These are all so wholesome. I love these. Oh, it's another facebook marketplace It's a dish rack. I'm interested great. When do you want it? What are you interested in? You message me saying you wanted the dish rack. It's 10 bucks. Do you want it? That's on my rack. Sorry I'm selling the dish rack.  It's just taking screenshots of your own wallpaper and then printing it. That's so good Oh my god It goes forever and ever and ever just checking the weather Oh, no, boostains google rug stains. How do you clean boostains from a rug? Fuck. Oh, it's so unfortunate So nice, bro.  Is this your place? If so grandma will come and clean and give you furniture. I have nothing else to do That's that's so nice though. Just wants to help Please help me. I'm in longitude zero and latitude zero. Please help me Oh grandma, maybe it's not always about trying to fix something broken Maybe it's about starting over creating something better And that's why you have a younger sister.  Oh New Zealand police. What are you? What are you doing? We have to tell someone their family member has died in a crash. This is the worst. Yeah, it's probably worse for them Who's running that I need to go get my hair colored. I'm going to be uh a brunette soon I'm more concerned about the drones casting firebombs down from drones over the columbia valley and North west north north west new new northwest Yeah, and burning our caged our aged old forest in the mountain side will be bald and the enemy enters the u.s To consume our country. Yeah me too. Donna. Sure Keep yourself safe I also love that when old people are like, I'll just make anything an acronym even if it's not Commonly I'll just you know, you should know what it means Bryce miss you and love you so much. I can't wait to see you this weekend.  Love you miss you I told them that you're circumcised and they loved it Carl This is so true Me showing a random video from the internet. Is this someone you know? Uh, yep sure Happy birthday. I happy birthday, Lindsay and many more returns.  Love truck. No truck.  I came out so amazing. Why thank you for the compliment Ah What am I doing right now? I'm not providing any kind of commentary. I'm I'm just reading the post and giggling I mean Pick them up and throw them back to where they came from don't eat too much pizza Lasagna and get bloated with gas That's it.  So this year I've discovered I'm happy pan or at least I'm not as straight as I imagined And that's okay. Still trying to figure out Still trying to figure it out Uh and all but it's an interesting journey Not something I thought I'd learned at 28 years old but better late than never Pan is awesome to love all is a gift Alice Good for you. Next time we talk, please explain I So funny Oh, this is not google my bad Search this is not the goggle Search google for apples Thank you love grandpa One star Some people do when they're older just go and yelp and give reviews for places they've never been 69 it's a bad y'all should try it sometime Is that a way of saying you're 69 today? If so, happy birthday from Linda and me. Happy birthday Oh boy. Oh boy Got married. Please don't share your personal problems here Just I love you too.    Hope you enjoyed if you did make sure to slap that like button right in the face And I will see you guys in the next video. Love you all stay cranky. Bye


Live from Las Vegas, it's theCUBE covering Oracle Modern Customer Experience 2017, brought to you by Oracle. Okay, welcome back everyone, we are here live in Las Vegas. This is SiliconANGLE Media's theCUBE, it's our flagship program. We'll go out to the events and extract the seeds of noise, talk to the influencers, the experts, thought leaders, CEOs, entrepreneurs, anyone we can that has data will share with you. I'm John Furrier with Peter Burris, my co-host for the two days here. Our next guest is Jay Baer from Convince and Convert, CUBE alumni, great guy, super influential, noses, marketing stuff, perfect guest to summarize and kind of package up what the hell modern CX means here at the Oracle show. Welcome back. Good to see you. Good to see you guys, welcome. Yeah, so thank you. So you were hosting the CMO Summit that was going on in parallel. They had the Markies Awards, which is their awards dinner. Big time, 11th annual Markies Awards, man. It's like a thing. It's amazing, it looked like the Golden Globes. Yeah, it was beautiful this year. I mean, it was like legit. Is it the one with the O on the top? And they've got the, and they delivered an award with a drone. It was a really, it was a great night. It was like fun. Awesome stuff. So give us the package here. I mean, what's going on?  Yeah, I mean, I think the story is two-fold. One, Oracle is going to interesting take on the marketing software space because they really are trying to connect it between the overall customer experience initiative and then marketing as a piece of that. So this event in particular, the modern customer experience event has tracks, almost full conferences for marketing, for customer service, for sales and for commerce, right? So all four of those are the verticals underneath this umbrella. And that's a really unusual kind of a conference setup, but I think it reflects sort of where Oracle's head is at from a thought leadership standpoint that like, look, maybe we're going to get to a point where marketing and customer service really are kind of the same thing. Maybe we're going to get to the point where sales and marketing really are kind of the same thing. We're not there yet by any stretch of the imagination, but I think we all feel that convergence coming. And my world and the marketing side, CMOs are starting to get more and more responsibility inside organizations. And so if that happens, if we do need to start to align the software as well. So it's an interesting take on the market. And I think it's sort of prescient for where we're going to head. It's interesting you mentioned of all those different silos or different departments or different functions in a digital end-to-end fabric. Experiences are all about the customer. It's one person. They're going to have different experiences at any given time on that lifecycle or product spectrum or solution spectrum. So the CMO has to take responsibility of that. Well, I feel like somebody has to be responsible for it. Mark Hurd said this in one of his remarks over the course of the shows as CEO of Oracle. He said, look, there is no data department, right? Everybody has to be responsible for data, but somebody has to figure out what the ins and the outs are. And maybe that's the CMO, maybe it's a CXO. I don't think we've fully baked that cake yet, but we're going to have to get to the point where the sort of single record of truth about the customer and their customer journey has to exist. And somebody has to figure out how to wire all those together. So we're getting there. It was so funny. I was joking, not here on theCUBE, but in the hallways about the United Airlines snafu. And to me as a kind of developer mindset is like software should have solved that problem. They never should have been overbooked to begin with. So if you think about just these things where the reality of a consumer at any given time is based upon their situation. I need customer support. I need this, I need that. So everyone's got to be ready, customer ready with data. They can't say- It's all about relevancy. Look, relevancy is the killer app. That's it, right? And relevancy is created by technology and with people, people who actually know how to put that technology into practice in a way that the customers actually care about. So one of the other things that Mark said, he said, look, here's the issue. It's not about data, nor is it about cloud. It's not about any of that. It's about taking that data and creating understanding out of it. But he has said a really interesting thing. He said what we have to do is push those understandings out to the front lines where somebody on the front lines can do something with it that actually benefits a customer. And I think that's a really smart point because so often right now we're talking about, oh, we've got these data stores and we've got DMPs and we've got all these things. That's great, but until that gets manifested at the front lines, who cares? You just got a big pile of numbers. We just had Katrina on from the commerce side and it was funny, she was making a retail comment saying, look it, they don't care about the tech. They don't care about blockchain and all the speeds and feeds. They want to do a transaction in the speak of the consumer. And the language of the customer is not technology. No, they don't care. They just solve my problem, right? Just solve my problem. I don't care how you solve it. What sort of magic you have behind the scenes. If I want a sweater, I want this sweater and I want it right now. Okay, Jay, so share with the folks watching and us conversation hallways, you've had. That's always the best. Because you had a chance, I see you had the big stage doing the hosting thing, but also, you get approached a lot and people bend your ear a lot. What's happening? You know what's been an interesting theme this week is we've made such great advances on the technology side and I think we're starting to bump up against, okay, well now we've got to make some organizational changes for that technology to actually flourish. We've had a lot of conversations this week with influencers, with CMOs, with attendees about I really want to do this and I really want to sort of bring sales and marketing together or commerce and sales, et cetera. But our org chart doesn't support that. The way our company thinks, the way our people are aligned does not support this convergence. And so I think we're at an inflection point where we're going to have to break apart some silos and not data silos, but operational. Like what is your job and who manages you and what is your bonus based on? There's a lot of legacy structures, especially at the enterprise, that do not really facilitate the kind of cross-departmental circumstances that we're looking for. So a lot of people are like, oh, wow, we're going to have to do some robust organizational change and that ain't easy. And somebody's going to have to drive that, right? Your marketing practitioners, which is my world, they can't drive that. That's got to come from up here somewhere. And also people got to be ready for the change. No one like to change. But we were talking about this yesterday called add the agile process, the development, being applied to marketing, rolling smart. Oh, we're seeing all the time, so many marketing teams now are using agile and daily scrum and standups and all those kind of things as opposed to Waterfall, which everybody's used forever. I think it's fantastic. Yeah, and that's something that we're seeing. And Roland Smart kind of pointed out, he had a book, got a signed copy, Peter and I. But this is interesting, if you go agile, that's to your point, you just can't read the book. You've got to have a commit to it. The organizational impact is agile. So one of the things we had in the CMO summit, we had like 125, 150 CMOs from all around the world. And one of the things we talked about in that session yesterday was, geez, we need to try and start taking people or hiring people out of a software development world, people who have agile experience and put them as PMs on a marketing team, right? Which is going to put that group of people who have the agile background in even greater demand because they won't just be doing tech roles for project management but also marketing project management and sort of teaching everybody how agile work. I think it's really interesting. But they've been doing that for a while. Yeah. I mean, the agile started in software development but moved broader than that when it went to the web. No question, but a lot of these CMOs do not have those type of skills on their team today. They're still using a waterfall. Or they don't recognize that they have the skills. Most of them will have responsibility for websites and website development. So it's that they don't... They're not thinking about it. It goes back to the issue of do they really appreciate... The web versus the marketing, yeah. They may not, they probably have it somewhere. They just don't appreciate it and elevate it. It's siloed even within the marketing team. It's siloed within the marketing team. So there's going to be, I mean, these are consequential changes. And we'll see the degree to which it really requires a whole bunch of organizational stuff. But at the end of the day, you're right. It's a very, very important thing. What were some of the other things the CMOs were talking about? Other than just organizational? Well, actual other sort of baseline skills, right? So it wasn't that long ago that your social media teams and content marketing teams, it was manifestly a written job, right? You made things that were rooted in copy. And now we talked a lot about like, you have to have like a full video team on your marketing org chart because the corner of the realm now is video content. And while companies are getting there, it's still a struggle for a long time. Because if we have our agency do this, we get somebody else to do it, and they're like, now I got to have all these people. I got a video editors and a camera crew. And I say, oh, of course it is. Not everybody can be the cube. Well, they're trying. No, but I think video is becoming down to the camera level. And you see Facebook with VR and AR, certainly the glam and sex appeal to that. And then you got Docker containers and you got software development apps. So I call that the app culture. You got the glam apps. And then you got cloud. So those things are going on. So are the marketing departments looking to fully integrate agency-like stuff in-house? Or is the agencies picking up that? I mean, what's your take on the landscape from video and some of these services? It depends on how real time they're thinking about video, right? We're starting to see Facebook live in a public relations circumstance, right? You saw when Crayola announced the death of the blue Crayon or whatever it was a few weeks ago. I mean, they did a press release on it, but the real impetus for that announcement was a Facebook live video, right? Which puts Facebook and live video essentially as your new PR apparatus. That's really interesting. So in those kind of circumstances, the question is, okay, do we do that with the agency? Is it easier to do it in-house? I think ultimately my advice would be you have to have it in both places, right? You have to be able to do at least some things in-house because you've got to turn it quickly. And then maybe for things that you've got more of a lead time, you bring your agency. One of the things we're seeing and just a common thing while we're on this great thousand weeks of our business as well is content is hard. Good original content is what we strive for as SiliconANGLE and Wikibon and theCUBE is something that we're committed to serving the audience. At the same time, we collaborate with marketers in this new native way. So the challenging I see in this marketing cloud is content is a great piece of data, okay? Content is data. Content is data. And it also helps you get more data because there's a lot of information exchange. So a lot of companies that I see that fail on the content marketing side, they don't punch it in the red zone. The balls on the one-yard line, all they got to do is get over the goal line and that's good content and they try to fake it. And they don't have authentic content. Another way of saying that. Another way of saying that, John. Guys, you blew it at the one-yard line. Yeah, another way of saying that is that the historically agencies have driven the notion of production value. And they have driven the notion of production value to make the content as expensive as possible because that's how they make their money. When we're talking about is when we introduce a CX orientation in this mix, now we're talking about what does the customer need in context, how can video serve that need? It's going to lead to a potentially very, very different sort of production value. You bring up a good point. I want to get Jay's reaction on this because he sees it a lot too. Context is everything. So at the end of the day, what is engaging, you can't buy engagement. It's got to be good. What serves the customer. If the customer, and that is defined by the customer, you can't, there's no silver bullet. There's no engagement bullet. Hey, I just bought engagement. Sometimes you can argue that the customer values a lower fidelity content execution because it has a greater perceived authenticity. Well, you may not know this, Jay. I'm going to promote us for a second. A piece of video that's highly produced in the tech industry generates attention for minute and a half to minute 45 seconds. The cube can keep attention for 12 or 13 minutes. Sure, right. Why? Now, if we were a digital agency. I would say the hosts, obviously. The hosts, the conversation, the fact that it informs the customer. And that's what increasing. I think these guys have to think about. So in many respects, we'll go back to your organization question. I want to test you on this. Is it in many respects that the CMO must heal by self first, starting to acknowledge that we have to focus on the customer and not creative, and not the agency. And rejigger things so that we can in fact focus on the customer and not the agency's needs for us to spend more. There was one of the great conversations in the CMO summit was this point that, like, look, we have all this technology now, and we have all these opportunities, and darn it, all we're doing is finding out other ways to send people a coupon. Like, isn't there something else that we could use this technology for? And what if we just flip this script, right? And said, what do customers genuinely want? Which is knowable and certainly inferrable today in a way that has never been historically. Why don't we use that data to give them what they want, when they want it, how they want it, instead of constantly trying to push them harder. Folks and value, and not being annoying. I mean, I wrote a whole book about it, Lou, and... Well, your key point there is they can infer and they can actually get signals that have never been named before. Chatter signals. But let's use them for good, not evil, right? I think it's the subtext there. Don't jam a coupon because that's right. But as Mark said, it's hard because CEOs are under tremendous pressure to raise top line in an environment that is not conducive to that. You're going to have to take share. The economy is not growing so fast that you can just show up and grow your company. And so CEOs have tons of pressure. They're then dropping that pressure on the CMO that says, okay, you need to grow top line revenue. So the CMO says, well, we've got all this technology. I guess we'll just send out more offers. We'll have a stronger call to action. And as opposed to using this information to inferences, the data, to be more customer focused, I think in some cases we're being less customer focused, which if anything is short-sighted and at worst is a crime shame. And so the solution there is to use the data to craft relevant things at the right time. To the right even. And it will work, but it requires two things that a lot of organizations simply don't have. Time and courage, right? It requires time and courage to purposely push less hard, right? Because you know it will pay off eventually but you've got to buy into that and that ain't easy always. And sometimes it's not even your decision. Well, what we don't want is we don't want to automate and accelerate bad practices. Right. And at the end of the day, what CMOs are learning, I think, I wonder if this conversation came out yesterday is, geez, maybe marketing really isn't that good. Maybe we have to learn ourselves from what this technology is telling us, what the data is telling us and start dramatically altering the way we think about marketing, the role the marketing plays, the techniques we use, the tactics we use, that will lead to organizational changes, blah, blah, blah. And I'm wondering, did you get a sense out of the session that they are in fact stepping back and saying we got to look in a mirror about some of this stuff. Absolutely, absolutely. And I thought it was remarkable considering he runs this company. Mark Hurd came in and did a little Q and A at the CMO Summit and he said, well, this is a guy who runs Oracle, right? Who's putting this whole thing together. He's selling tons of marketing software and he comes in and says, look guys, I'm not even sure if what we're doing here is right because we've got all this technology. We have been doing this for a long time. We've got all these smart people and still what's our conversion rate? 1%, we've got the greatest technology in the history of the world. We supposedly know all this about customer experience and customer journey mapping and our conversion rate is still 1%. Maybe something is fundamentally broken with how we think about marketing. I thought for somebody in that role to come in and just drop that on a group of CMOs, I was like, whoa. I think he's right. He's totally right. But to have a CEO of a company like this just walk in and say, here's what I think. I think people have, I think, I mean, this is a question for you and I'll ask it by saying, we try to observe progressive CMOs as a leading indicator to the comment you mentioned earlier, which is flip things upside down and see what happens. What are you seeing for those progressive CMOs that have the courage to say, you know what, we're going to flip things upside down and apply the technology and rethink it in a way that's different. What are they doing? One of the markers that we see on the consulting side of my business is CMOs who are thinking about retention first. Not only from a practical execution layer, but even from a strategic layer. Like what if we just pulled back on the steering wheel here a little bit and said, how can we make sure that everybody who's already given us money continues to give us money and more so and essentially really turn the marketing focus from a net new customer model to a customer retention and customer growth. And I'll start there, right? Start with your current customers and then use that, those insights gained and then do a better job with customer acquisition. And so as customer service and marketing in particular start to converge mostly because of online. Online customer service is very brand driven and more like marketing. So as those two things are converging, we're seeing smart CMOs say, well, what if we changed the way we look at this and took care of our own first, learned those lessons and then applied them outwardly. I think that's a really strong marking signal for professional CMOs. It's a great starting point. And it's almost risk-free from a progressive standpoint. It's not always risk-free inside the organization. Yeah, well, I mean, it's harder to get new guinea pig customers to see what works. Go to your business customers and say, we have data to work with. But wouldn't you also say that the very nature of digital which is moving the value proposition from an intrinsic statement of the values in the product and caveat and toward towards a utility orientation with the values and the use of it. And we want to sustain use of it. We're moving more to a service to do that. And digital helps us to do that. That the risk of taking your approach goes down. Because at the end of the day, when you're doing a service orientation, you have to retain the customer because the customer's constantly got an opportunity to abandon it. Yes, I mean, the ability to bail out is very, very easy these days. I completely agree. But what I find is that it makes sense to us, right? It makes sense to us on theCUBE. But in the real world, it's not. Not everybody's drinking that punch yet. So, I don't know. I'll see you in here. It's not like courage. It is definitely courage is one of them because you're essentially saying, look, I've been taught to do marketing one way for 40 years or 20 years. Yeah, we know my email marketing all day long. Yeah, I'm just going to keep pressing send. It's easy. There's almost no net cost. So there's that and also just the pressure from above, I think, from the CEO to grow top line, net new customer revenue. I think that's certainly part of it. And some of it is, I think we went back to earlier about org charting and skills and resources. There's a heck of a lot more people out there at every level of a marketing organization who are trained in customer acquisition more so than customer retention.  Zero. How many MBAs are there in marketing and sales? There's a lot of them. 500,000. A lot of them. Right, but they were trained there. They were trained there. They didn't come in like that. So they trained them up. Jay, great to have you on the queue. Great insight as usual. And I think you're right on the money. I think the theme that I would just say for this show, we agree with you, is that if you look at Oracle, you look at IBM, what Amazon's doing, Microsoft in some way, maybe a little bit, but those three, data's at the center of the value proposition. And Oracle clearly is saying to the marketers, at least marketers, if you want to say digital and end-to-end, look, if you use data, it's good for you. This is the new direction. If you think data-driven, CMO, that seems to be the right strategy in my mind. So I think- The best quote in the CMO summit, and you guys need a cube bumper sticker that you can manufacture, was data is the new bacon. And I was like, oh, I love that. That's the best, right? I'm like, I love it. Who doesn't love bacon? Jay, great to see you. Real quick, what's up with you? Give us a quick update on your opportunities, what you're doing these days. Great, running around the country, doing fantastic events just like you guys are working on a brand new content marketing masterclass for advanced marketers on how to take their content marketing strategy to the next level. That launches in a couple of weeks. Continue to do, we're doing four or five podcasts a week and a new video show called Jay Today, where I do a little short snippets, three minutes a day. JayToday.tv, if you want to subscribe to that. Beautiful. Jay Bear, great to see you guys. Great to see you guys. Great thought leader, great practitioner, and just a great share on the net. Check them out. I'm Peter Burris here at Oracle Marketing CX. More live coverage after this short break.


Welcome to this brief introduction on how you can get your data in string. The string database integrates public data on both physical interactions and functional associations. If you're not already familiar with the string database, I highly recommend that you go watch my separate introduction video first. However, no matter how hard we try, we cannot have all data in string. Especially, we cannot have your data if you haven't published it yet. This is where the myData part of string comes into play. It allows you to upload data and thereby effectively expand string yourself. The key to this is your string account. Login is optional when it comes to string and most users of string never log in. However, if you log in, you get additional functionality in the form of the myData part. To log in, you can either set up an account with email and password, or you can use one of your existing credentials from Facebook, Google, LinkedIn or Microsoft. Regardless of how you log in, you will afterwards have access to the myData page that looks like this. It has four sections. The first two are basic features that are designed to save time for you. This is the browsing history that allows you to revisit earlier results without redoing the queries and the stored gene sets that allow you to upload lists with your genes of interest, be it the differentially expressed genes from your own expression study or disease-associated genes for the disease you are working on. The last two sections provide advanced features that I will cover in the next two parts of this presentation. The first is payload data. This is how you can put your own data in string, adding new nodes, for example, non-coding RNAs or viral proteins, and new edges, for example, interactions from an interaction screen you performed in the lab. You can also add colored halos around the nodes, thereby color-coding expression data onto the network or highlighting specific types of nodes of interest with different colors. You can add a color legend to explain what the colors mean and a logo to the page to brand it as yours. You can add more information to the pop-ups, both the node pop-ups and the edge pop-ups. This can be either in the form of textual descriptions, just putting in information about the genes and proteins or interactions and external links if you have your own web resource that you want to link out to. When you do this, you can get a network that looks like this, here illustrating the colored halo functionality. We are also showing viral proteins interacting with the hosts so having both new nodes and new edges. This is an interactive resource that allows you to view your data inside string and it also allows you to share the resulting resource with others. However, you need to be aware that it requires you to prepare the data in a very specific file format and therefore some coding will be required. The second advanced feature is the annotated pro terms. One of the common requests we get from users is please add organism X to string. And I'm sorry to say we cannot add every genome to string. It doesn't scale and also the long update cycle of string means that adding genomes on demand is not an option. However, we recently added a new feature that allows you to upload a pro term in the form of a fast day file that has your protein sequences, the corresponding gene names and optionally text descriptions for them. We will then use the sequences to predict orthologs, transfer interactions and that way produce a predicted network. We'll also use the orthologs to transfer functional terms to provide enrichment analysis functionality. In other words, we're providing the full string functionality for your organism and all you have to do is upload a faster file. This is summarized nicely in this figure. We have the precomputed string network, we have your faster file with your sequences and based on that we predict orthologs, predict a network, predict functional annotations and provide all of that both through the interactive web interface that you're used to from string and via the programmatic access with the string API and make it all available as download files if you want to analyze the network outside string. In other words, you have really added your organism to string with the full functionality that would have been there if it was in string from the beginning. The one thing to be aware of is of course we have no direct evidence from your organism. It's all based on transferred evidence only. That's all I have to say about the my data part of string. If you want to learn about another way of combining your own data with the string network, take a look at this presentation next. Thanks for your attention.


Well, hello everyone. Thank you for joining us again for another edition of Dr. Jill Live. I have got a real special guest this evening and super excited to hear all the new things in biotechnology and wearables and in really the future of medicine. We have a leading expert today, Dr. Frank Lipman, founder of 1111 Wellness Center and chief medical officer at The Well, both in New York City. He's a New York Times bestselling author, having written several books on health, including Better Sleep, Better You, The New Rules of Aging, Well, How to Be Well, and the New Health Rules. He is recognized as a pioneer in integrative and functional medicine, what you call good medicine, which I couldn't agree more. Dr. Lipman, welcome.  Great. Lovely to see you again. We haven't seen each other for a while. Yes, yes. And I know it's always fun when we do connect just hearing what's going on in your world. And I'd love to just start with, what's your most recent book? And tell us just a little bit about that. And then we'll go into some of the wearables and stuff. But I want to first highlight the fact that you are a New York Times bestselling author and have written a lot on these topics. Right. Well, my latest one is on sleep, which is all right. But the one before that was more interesting was on aging well. You know, as we get older, I'm now 67, and you start, you know, thinking, you know, I have a grandson, you start thinking about what you can do to stay healthy. And it was just interesting as I got more and more into the research for that book, how interesting it was to find things that I wasn't doing or wasn't telling my patients simple practices. So I thought that was really interesting. So I really like that book because that's now become what I talk about in that book is sort of now becoming very popular. And, you know, the book on sleep is just a book on sleep. I mean, there's nothing new in it. Oh, but there's so many and so many people listening, they're like, Oh, what does he have to say? So in aging, what would be like the top three tips? I'm like you when I read some of these things, I mean, we live it, right? Like we like to show up and try to practice what we preach. And I know I have found so many things through my own life and experiences that work. And then I get to share them with patients or ask colleagues. What would be your top three tips on aging well or living life vibrantly, as long as we can? Well, I think understanding the concept of hormesis is important. That the idea that little stresses are actually good for the body.  So these little stresses like high interval, high intensity interval training, where you push your body for little periods or fasting, where you actually stressing your body by not eating or temperature extremes by going from a sauna or just doing a sauna but jumping from a sauna into a cold plunge.  They work with our longevity genes. So there's so many little things one can do, fasting. For instance, I only eat two meals a day now because I used to always think breakfast was such an important meal. And now I do so much better as do so many of my patients do so much better by just having a cup of black coffee in the morning and I eat at probably 12 or one o'clock. I don't even feel hungry. I end up eating less, which is particularly good for aging. And I, you know, this mechanism of hormesis kicks into my body, which triggers these longevity genes. So I think fasting is really helpful. Eating less is really helpful. Obviously, eating as little sugar as possible is really helpful. And then, you know, exercise, you know, the standard things we talk about are all really helpful for aging. Sleeping is important. And then, you know, I started researching a lot of supplements, which can be helpful too.  You go through, yeah, when you do the read, I'm in the middle of writing my first book. And so I totally understand how that goes. I love that you said, though, the caloric restriction in my mind and the research, that's probably one of the best mechanisms, which is there's multiple ways whether it's eat less, and sugar has such an inflammatory effect. Like you said, I had cancer at 25. So I know well, the effects of sugar and inflammation and cancer. And I realized that was one of those pieces of the puzzle years ago. So caloric restriction. And then sleep is its own book and its own hack for aging, isn't it? I feel like that's one of the kryptonite things in people's lives is lack of sleep or sleep issues. In fact, if I have someone in front of me, and they don't sleep well, it's usually literally the first thing I want to address. Yeah, I think sleep is one of those, you know, we always talked about the three pillars of health, exercise, stress reduction and diet. And we sort of left out sleep. And, you know, the more, once again, the more research you do on when you write a book and you realize the problems associated with a lack of sleep or not sleeping well are enormous. And what's really interesting is I always believed, and most people believe that as you get older, you need less sleep. Yes, you tend to sleep less because it's harder, but it's just as important, if not more important, to really take sleep more seriously when you get older. You know, for instance, I wake up at five o'clock every morning, that's what I do. But I don't go to sleep at 12 o'clock, I'll go to sleep at, you know, nine o'clock. So I think you've got to adjust accordingly. And I think sleep is a really important hack, yeah. And now we can measure it to a certain extent, you know, they're all the... And you held up the O-ring, maybe? Yeah.  I'm definitely, you said I'm an expert. I'm not an expert on self-measurement on buy, you know, it's all the buy hacking world that we're now starting to incorporate into medicine. And I'm definitely not the expert. It's the younger guys. You know, I'm part of a startup where all these young guys are incredibly, incredibly smart docs and so together know so much about these wearables and the tech and that. So I just find it's interesting that we can now incorporate it into the way we practice. You know, we've practiced, you know, we started off with, I started off as a Western doctor and we got into Chinese medicine and in the 80s, in the sort of mid 80s when I came here. And that was an inflection point for me. And I think for the culture realizing that there was this combination of, you know, how do you combine Western and Eastern medicine? And then Jeff Bland sort of came out with this whole functional medicine concept, which was an inflection point. And I think we had another inflection point where a few years ago, we started incorporating genetics into the way we practice, which I think is extremely important. Getting someone's blueprint, because your blueprint is different to my blueprint and how I respond to the world or how the world is going to affect my genes is going to be different to yours. I think incorporating sophisticated nutrigenomics or nutrigenics, whatever you want to call it, into our practice of functional medicine was a huge, I mean, that's been a game changer for my practice when I can, you know, measure all these snips and see how these snips work together and see how someone lives their life according to the snips. And I'll give you an example of myself. And then now we have this layer of wearables on top of it. So you got someone's blueprint, you got all the epigenetic lifestyle changes that we recommend. And now people can actually monitor their progress, you know, we can do this plus all the biomarkers. That's very, very exciting time in medicine. Well, I love you title or talk, the future of medicine is now because that's exactly, I feel the same way. In fact, if anything, we almost have too much data, although can you really have too much? Well, no, that's an important point. Yeah, I think people can get overwhelmed. So it's how you use all that data, which is very important. That's where our role is so important, you know, what, what is important and what's the data to use, et cetera, et cetera. So yeah, I think that's an important point. And are you using as far as data, and obviously we both have our ORA rings and we, we love that I think a lot of patients do are they have other wearable devices, but like heart rate variability sleep, what are some of the top things that you find for biomarkers that are helpful? And there's a lot we could talk about, but what would be your key ones that you might ask a patient about or, or look at with them? Well, you know, I do extensive blood testing. So I do, you know, an advanced lipid panel where we know, same as probably you do, we're looking at so many markers for inflammation and for metabolism or metabolic health that we weren't doing a number of years ago. And now we're doing all the time, whether it's epilepsy, you know, for instance, the regular cholesterol test that most doctors do is completely useless. Absolutely. Yeah, a total cholesterol, it's good and bad together. You can't really make any inferences. Yeah.  So, you know, now we have, you know, whether it's the Cleveland heart panel or the Boston heart panel, there's so many more markers that can actually help us, whether it's epilopropyrotin B, lopopyrotin A, TMAO, I mean, ADMA. There's so many markers in a, in a panel now, which are very helpful. And then you can mark, you know, insulate, you can measure insulin resistance and metabolic health. So there's so many different markers that can help pinpoint someone's treatment. And then if you want to take the heart health further, you got the, you know, we used to have a calcium score, which is just measuring heart block. Now you can do a clearly, you can do basically an angiogram, you can do a clearly test which measures soft block. I mean, there's so many tests that one can do now to sort of really help people get to another level. Yeah. And it's not, like you said, it's not just the old school thought was we hit 60 and we started to decline. And I think that's one of the things we see in the US especially compared to even other societies and maybe take their, you know, diet and nutrition a little more seriously is this massive decline after the age of 60. But the idea is that we perform vibrantly into maybe our nineties and then just fall dead one day of a heart attack. Exactly. So that's what I want to be. You know, I have a two year old grandson.  It's like a lot of hard work and exercise. I want to continue doing that. So absolutely. So obviously these labs, we have so much access in the genetics. Do you have any favorite genetic labs that you use? Or I use three X for genetics. I think they, you know, dabbled with a couple of them before and they found them to be by far, by far the best. Now I'm biased as well. You know, I'm going to be on the advisory board, but I use them all the time now. Almost all my patients get a three X for genetic test because I find it so helpful. You know, not that the other tests don't do it, but an example of how helpful genetic testing is, I'll give you my example and we use a common gene, but not all of them. Most of them will measure this gene, you know, the APOE34 gene, which is now, it's called the Alzheimer gene. So I was, you know, I first, many years ago, became pre-diabetic eating what I thought was a healthy vegetarian or pescatarian diet and, you know, realized I was pre-diabetic. And then I became eating started more, eating more paleo and tons of saturated fat. And yes, I lost weight and felt great and my numbers corrected, not my cholesterol. But when I did my genetic test, I found out I was APOE34. I had an E34 and someone like me with this, that genetic variant, you shouldn't be eating too much saturated fat. So although I don't think saturated fat is a problem for everyone, but if you have that gene snip, you know, you've got to be careful because that gene snip is part of the snip sort of affects how these fats are metabolized. So I changed my diet again to eat less saturated fat. So I think knowing, you know, there's so many things in these genetic tests that you can pick up, which will tell you if you're predisposed to certain things. So that's just one example of, you know, how you can actually shift people's diets the way they exercise, how quickly they recover or if they're prone to get injury or types of exercise are good for them. So I think there's so many things you can pick up in these genetic tests, which are very targeted for the particular person. I love those examples because APOE, if you're listening, the APOE34 is a really big deal. And the four fours, they can have upwards of 50 to 90% risk of Alzheimer's. So really important to know because that particular person especially should not be on high saturated fats. They actually grab onto the fats and store them in the heart and the brain. And I were just at higher risk for those lipid issues and inflammation. So I love that. And like you said, I found same thing with some of my genetics, like I'm, I do so much better on muscle weight training kinds of programs than a super high cortisol, like a long run, I was raising my cortisol way too much. I tend to that naturally. And I did a lot better when I really pulled back and did more walking, hiking and then some weight training. I don't really do running anymore at all. I know that I was doing the wrong thing for my body. And we're talking about functional medicine is a foundation, but personalized is where it's really at. Yeah, I think functional medicine is great. But if you really want to personalize it, you need to do genetic testing. And then I think the future is going to be continuous blood glucose monitoring. If you want sleep monitoring, you know, there's just going to be more and more self monitoring that one can do. And really, like you said, what we're doing is empowering the patient because they have the data and even though we ask, I'll ask patients all the time, how's your REM, how many hours or minutes are you getting your REM versus deep, what time of the night do you go to bed, all those details and heart rate variability, a whole nother thing we could talk about. But the deal is that patients like for me, myself, I've done tons of biohacking interventions, my PMF mat or my PMS mat. Yeah, I love, love, love. But what happened is what I would see is all of a sudden my deep sleep doubled. Or, you know, I intervene with it. I'm like, okay, this really works at least for me. And then I know it's a good thing because we can. Yeah, I think that's very, yeah, I think that's very empowering because you don't have to wait three months, six months a year to get your bloods done or whatever it is, you can actually monitor it yourself. So I think it's, we, as I said, we're getting to that another inflection point where people can really take more control over their health. Yeah. And so what would you say as far as supplements there are hundreds and hundreds of things we could recommend? Do you have the top, like three to five things that you would not want to be without or that you in patients feel like are some of the rope besides like maybe D, I mean D is a critical one. Yeah, no, I mean, there's a standard magnesium D for sure or whatever. But yeah, so once again, it depends on your genetics, but I see a lot of people with a SNP, a genetic variant where they have a deletion of an important enzyme in the liver, the GSTM1 deletion. So anyone with that, including myself, needs to be on sulforaphane. So I use sulforaphane a lot. I'm a huge fan of berberine for, you know, whether it's lowering sugar, anti-aging, I take NMN and recommend it a lot. I'm sure you've talked about NMN or N-R, Nicotinamoribus, that is a big one, but I actually like the NMN. I think NMR or N-R is still owned by one company, Chromedex, who makes Tunayagen. Exactly. Which is a great product, but NMN is just as good, I think, would you say? Yeah, I like it. There's a Swiss company that's now coming. I use their Elevent. I use their brand. I should actually hook you up with them. It's really fantastic. I mean, started by this crazy French millionaire who saw his father help, I'd say, just got so passionate about it. And he's doing all this research. He's got a lot of research.  I will follow up with an email after. Yeah, I use NMN. I use berberine. I use sulforaphane. And then coenzyme Q10. I take supplements according to my genetics. I have terrible genes. I take CoQ10. I take alphalipoic acid. I'm starting to use more and more the specialized pro-resolving mediators. Yes, love. This is SPMs for those of you listening. Yeah, SPMs as anti-inflammatories. I'm starting to use that more and more and more and more myself. So I think everything's sort of being taken to the next level. So it's very exciting. Now, it's interesting you mentioned SPMs because what I found with the pandemic, there's a massive increase in mast cell activation triggered by this virus and other infections. And those SPMs are antiprostic landon, which is really good when you have a mast cell issue or chronic pain inflammation. And again, we're seeing more and more cases. I don't know about you, but like long COVID is going to become more and more of an issue. Well, long COVID, I use SPMs all the time. I use SPMs, Corsiton was the other one I didn't mention. For long COVID, I use Corsiton, SPMs and NMN all the time. Those are part of the treatment. I mean, the whole histamine issue is very interesting. And the genetics come in there as well, because with the genetic testing, you can actually tell if they have a DA, if they're not actually breaking down the food properly, or they're not metabolized. The different genes will tell you where the histamine problem is. And most people think histamine is just this allergic response, but histamine overload or histamine response presents as inflammation in many ways. So that's been a real eye opener with the genetic testing, this whole histamine concept and understanding mast cells and what that actually means more. It really is. And I feel like we're at such a juncture in our culture, in our state of our world, because our toxic load is so much greater than it used to be that I feel like the pandemic was the perfect storm, right? We had this very aggressive and virulent virus, but we also had a weakened state of immune system for most of the world. So we were, I think, more susceptible than we would have been 50 or 40 years ago. And then the mast cells are just our primordial cells that kind of protect us from the environment. They're doing their job, right? But there's more things because there's more toxins, there's more infections. And I don't know about you, but I think mast cell activation types of syndromes have massively increased in the amount of people that we see them present in this toxic load. Any thoughts on toxicity? Because we talked about what we can add in, all these great tools, this great exercise of personalized medicine, but sometimes it's actually eliminating things. And I feel like starting there too can be a real game changer. What kinds of things are you seeing with toxic load in your patients? And any thoughts on that? Yeah, I think, you know, just to also get back to mast cell activation, I think a lot of that has to do with what's going on in the microbiome and the toxicity created by an altered microbiome and then damage to the gut lining and the metabolites going through the gut wall and overloading the liver with toxins. I think the gut microbiome, to me, is the area that I usually start with most people. Because most people, you know, whether you want to say we're doing a detox or they're toxic, whatever it is, I think starting with the microbiome and that will usually mean eliminating certain foods and putting them on some type of elimination diet, low histamine diet, whatever that yeast-free diet, they're all sort of similar. But putting them on some type of diet and then actually using antimicrobials like berberine and oregano oil, which actually help clear up the histamine. So they're not only antimicrobial, but they have histamine or histamine metabolizing effects. So, you know, when I first started using them, I just always assumed they were antimicrobials and they're working really well because they're antimicrobials. They are antimicrobials, but they also have histamine metabolizing effects, which, you know, just add another layer onto why they're so effective. Yeah, so crucial. And I think what people don't realize is we're talking like when I say toxins, people are probably thinking of heavy metals and parabens and phthalates and mold and all the things in our environment, chemicals galore. But we also have endotoxins, which are from inside out. So what you mentioned with the gut, if you have dysbiosis of fungal metabolites or bacterial metabolites or other types of organisms, overgrowth of E. coli or club C. l. These things absolutely contribute to toxic load from the inside out. So that's where berberine and oregano and some of these great herbs will decrease that load as they decrease that population inside. And I love the histamine. Yeah. Yeah. And I do think a lot of what I see anymore, often where I start off, is working on these endotoxins, because we talk about toxicity of these toxins coming from the outside, which are definitely real. And yes, we do have a detoxification system, which should theoretically take care of so many of these toxins, but we are overloaded. But it's just these endotoxins, the toxins created in our gut, which are actually a huge problem. And talking about the gut, something like SIBO has become the diagnosis du jour in Western medicine. They've realized that there's a problem of SIBO, not realizing that maybe sometimes it's funny that there's a SIFO or a fungal overgrowth. So they give this refactamine, which I'm not necessarily against refactamine, although it seems to have a temporary effect. People get better for a week or two or a month, and it comes back. But they're ignoring the other bugs, and in particular, the fungal, the SIFO, which will give you a more solid effect. So everything seems to be working together, but it's just interesting. Yeah, it's interesting what's happening.  Exactly. Mental nature. And I found in some of those cases that would have recurrence, patients can stay on them for quite a long time. Like berberine, I have people who are on that, you know, permanently. Me too. I take berberine every day now for more for an anti-aging effect and blood sugar effect. But I take berberine every now and I remember to take them. But, you know, the herbs also have an effect on, you know, sometimes some of these organisms develop biofilms around it.  I don't think, as far as I can see, the refactamine doesn't necessarily work on these biofilms with these actual mixed herbs actually have an effect on the biofilms as well. So they're actually not only safer, but they're much better. They are. They're more effective. I could, well, and I don't know my history, but at 25, I had breast cancer a year later. I had Crohn's disease. So I became a, I had to learn the gut because I had to heal from Crohn's. And I consider myself, you know, in our Western training, we're both at medical doctors. I'm told that Crohn's is incurable. I am, I consider myself cured. I have zero evidence for the past 20 years of Crohn's. And it took going exactly where we're going is to the microbiome and completely rebalancing that and calming the inflammatory response because Crohn's it's another gene, NOD2, and there's a few others, but it's just an abnormal response to a normal microbiome. So I had an exaggerated response and that damaged my gut, but I'm considered cured of Crohn's. And in our Western world, as far as our training, that's considered almost impossible. Right. Yeah. Actually, I often see Crohn's, I often see fungus or yeast in Crohn's. To me, someone has Crohn's, it's, you know, yeast until proved otherwise. I mean, obviously it's more complicated. Because there's so many docs who don't run just I completely agree in my own case was completely decreasing that fungal burden. Absolutely. And you think about the IBD panel we do on lab core quest journey, major lab, it's all anti carbohydrate antibodies. It's anti saccharomyces antibodies and anti-manuside antibodies. They're all yeast cell body parts. Right. So we're testing for the aggressiveness of Crohn's by checking for antibodies to fungal components. Right. I couldn't agree more. And again, I think docs are starting, most of our colleagues are doing this, but it's amazing to me how long it's taken some, you know, camps to really understand how much the microbiome affects all disease, especially auto immunity. Yeah. Oh, yeah.  And most autoimmune problems I see not everyone, but most of them start off with a gut problem. And most of those problems are people are young kids who got given too many antibiotics as kids. I mean, I'm seeing so much of that overuse of antibiotics, microbiome issues, eventually leading to autoimmune issues. I mean, that is probably one of the commonest patterns I see in my practice. Yeah. Oh, absolutely. Absolutely. And as I'm sure as you do, even if the patient is, you know, 85 years old, I'll say, where were you born? What was your birth like?  Because those things actually matter, lifelong with your diversity of your microbiome. Yeah. Refund. Wow. So we have already covered a lot. I was just thinking right next to me, I got a show for listeners because I've never shown this before and I happen to have it. This is my pills. I have the same thing. I just put in a, I take probably you're the first person I've seen it takes as many as me. But that's what I was going to say. People like, because the patients all the time will say, Dr. Gill, that's a lot. And I always try to meet them where they're at. So if they can only take 10, but I always say, okay, just look what I take. This is twice a day sometimes, you know. Yeah. I do that once a day. I can't do it. I should show my wife she can't believe someone else would take as many pills as I do. And I can kind of take them as a handful too. So I'm, yeah, I just, I'll take them all when I have my first meal after lunch or whatever it is. Yeah. What do you think is the biggest thing? And first of all, before I say that question, I just had another, you talked a little about your journey of you conventionally trained and then Eastern medicine. And what was the, was there an aha moment where you realized, gosh, there's, because I love my conventional training. I think we've got some of the best education in the world. But I think it's like, we have a bigger toolbox now. And I still, I feel like the best of both worlds is where the, the real truth lies. What was your moment of like, really did you like where you found functional medicine? And was there a moment of epiphany for you? Or was it a gradual thing? Well, my first exposure when, when I stood in South Africa is exposed to traditional healers when I was working as a student and then an intern in the hospitals in South Africa. And I was working in the biggest hospital in South Africa. Then it was during apartheid. So everything was separate. So he's working in the, the, the biggest hospital in Africa at the time. I don't know if it still is maybe. And when we couldn't help the patients, the family used to call in their traditional healer. And I noticed sometimes that sometimes the patients got better. It didn't make any sense to me because I really believed in Western medicine, but that sort of started opening up my mind. And then I got exposed to them again when I went to work in the bush. Same thing I saw. So that sort of piqued my interest more. And then when I came to work in a private practice afterwards, when I just finished my training in Johannesburg and people were coming in and, you know, they had these common chronic symptoms. They were tired and they couldn't poop in their headaches, had headaches and I couldn't help them with the Western medicine. And they just happened to be the same patients. It was like the hip practice in Johannesburg at the time they were seeing. There was one acupuncturist. They were seeing homeopaths. They were coming to me and I noticed that the homeopath and the acupuncturist was actually helping these patients that I couldn't help. So that was sort of my first awareness of all of this. And then the second big, a higher thing for me was when I came to the States, I had to do a residency in New York to get a license in New York. So I happened to get a job who sponsored me for a green card in the South Bronx. And I started doing a residency there and I wasn't, you know, I hated the medicine in America because it was, you didn't have to take a good history like we did in South Africa or examine a patient. There's all about, you know, reading up about whatever the problem was and presenting the next day. So there was no patient-doctor relationship. And so during my residency, because I was disillusioned, I'd heard about an acupuncture clinic that was attached to the hospital that was doing drug detox. So I went to check that out and fell in love with acupuncture. So that's a long story short. During my residency, I was going to the acupuncture clinic after hours and I saw that the acupuncture, Chinese medicine clinic was helping patients who had back pain and headaches and couldn't prove the same type of problems that we weren't helping in the hospital. We were helping acutely ill patients with, you know, heart attacks and pneumonias and broken legs. So it was pretty obvious to me that the future of medicine would be some combination of these two because they both were good at what they were good at, but not particularly good at what they weren't good at. So it's just so obvious that the future would be a combination. So that's sort of how it happened. Oh, I love that. I'm so glad that you told your story because really, truly that what I heard was this common theme and I think any of us who are in personalized precision, functional medicine, whatever we're going to call it, bringing these best of both worlds together is the curiosity, right? Like there's this curiosity of like, what else is possible or just the observation, the power of observing things that maybe we weren't trained in or didn't know about in our conventional training, but we're like, there's something there that's interesting, getting curious and learning more. And I've done that same thing. And I'm sure you in clinical practice, just like we're talking about biohacking, often it's like this, like, well, let's try this as long as it's safe. And then don't you sometimes see these things in your practice? I can't believe they've come back to me and say, I'm better. I'm like, really? Tell me more. No, no, that's what happened. I mean, that's how I got into biohacking from my patients telling me that. Yeah. Yeah. Wow, that's amazing. Well, I am so glad for your time today. I am like honored to talk to you and to have you here. What would you say as far as do you feel like some of the biggest changes or things that we've discovered in the last five to 10 years, most important things that have affected your practice or your treating of patients? Well, I think, well, I don't know what the five things. I would say sleep.  I think fasting is so powerful. The changes that we see with people's bloods and fairly quickly. So I think fasting is probably one of them. And sleep, like you said, we can't talk enough about it. Yeah, it's hard to sort of pinpoint, but obviously sleep seems to make a big difference. Yeah, what else can I say? I mean, I think that the genetic thing is, to me, has been a game changer because you can really personalize someone's treatment. Not everyone wants to take 50 supplements a day like us, so you can really target someone's treatment. And I think it's very powerful. Yeah. I do too. I think we actually simplify. Like you said, some of these things now I have a lot of genetic issues too. So that's part of that. But I think you're right. You can actually target and simplify because not everybody needs as high a dose as D as I do. Right, exactly.  And where can people find you if they want to know more or purchase your books? Yeah, just go to drfranklipman.com, drfranklipman.com. And then I'm also now chief medical officer or part of this startup. I'm just doing the part of the medical office. It's called joinhardt.com, which is sort of joinhardt, like H-E-A-R-T-Y. And it's a group that's actually doing genetic testing, blood biomarkers, and then wearables. And they've created an app. Beta testing now, where the app is you have an app where you can actually monitor all of this yourself all in one place. And you own all your own data, which is really interesting. That's rare now too, because all the companies are selling it. Exactly. So it's a very cool company. We should speak to you because we're going to need, you know, at the moment it's happening in New York, we're going to be spreading out. But to me, that's the future of medicine. You can do it all from your own home. It's fantastic. Gosh, I couldn't agree more. And what you're talking about is empowering our patients so that they can understand and own their data and make the decisions that are best for them. And I think our world is changing, where I mean, we're still a guide and often the tough cases come see us. But the more we can get our patients to be their own physician, how cool is that? That's amazing. Exactly. Love it. Well, thank you so much for your time. I greatly appreciate it. Thank you, Joe. Lovely chatting to you.


And I think what is fundamental for all of us is to make sure that girls get the same education, have the same equity available, so that they can develop into what they want to be. They may want to be a mother, others might want to be an executive like the woman that we heard on the show, but they should be given those opportunities. Not the case, not the case, still today. And I speak from experience. I have lived in a world of men, which is fine, nothing wrong with that, but women must be given the same equity and the same access as men.