As-salamu alaikum warahmatullahi wabarakatuh. I wanted to specifically concentrate on raising children, especially with everything we just heard from Shaykh Azaynab and the importance of really maintaining a strong identity in these times, how we can build our children with resilience. And so the first aspect of that is obviously in order to raise your children in a certain way you have to be able to model that in yourself. So the very first focus here that I hope, there's three points I'm going to address, but this one is the first, which is in our tradition the hadith that we usually reference especially with leadership in general is this particular hadith, which is every one of you is a shepherd and is responsible for his flock. And the hadith goes through the different roles of leaders, of men, of women. And so for women it's very clear here, a woman is the guardian of her husband's home and his children and she is responsible for them.   She has her staff and the shepherd is, if you have ever learned about shepherding, it is a role that requires a lot of knowledge.  And so I think the shepherd analogy is just genius on so many levels because in fact, again, as we see with mothering and parenting in general, there is no handbook, you do have to learn and the best way to learn of course is to surround yourself with excellent models, people that you can learn from. And so in our tradition, this is why it's so important, we were just having a conversation about women sharing spaces like this and learning from each other and having time to actually watch and observe. I was reading earlier about mirror neurons, this incredible part of our brain that helps us to be empathic. It's all through mimicking and modeling that we adopt those virtues and good qualities. It's because we're watching someone else. Now how many of you by show of hands in your mothering journey have you felt more isolated than surrounded by the village that we all need? How many of you have felt isolation? So when we look at why we struggle, a lot of times this is partly wise because we don't have that opportunity to watch our mothers and grandmothers and aunts and other female family members or friends who have children ahead of us. We're not really having those types of gatherings and meetings, we're not socializing on that level and that can make us feel very isolated. So shepherding back to this analogy, again, it's about leadership and really understanding what that entails. So specifically to shepherding, right? What do we get here? Being humble. This is very important. You have to admit that this is a new domain. You don't know a lot of things and you have to be willing to take advice, you have to be willing to open. You're going to have unsolicited advice if you've ever had children, you know what that is. You'll have people telling you about everything. How to dress your child, how to feed your child, how to birth your child, all of it. But that's okay. Let it, you know, Hamdullah, welcome that because this is a domain that you haven't yet learned about. So humility is really important. Responsibility. Motherhood, parenting in general, it's an amana, just like the shepherd is responsible for the flock. Allah is giving you the charge of making sure they're well fed, they're safe, that you're protecting them from the harm.  People just want to have little trophy children. This is totally, you know, alien to our tradition. I remember many years ago I had a debate with a brother, Mashallah, he was a very learned brother and he made a claim. He said most parents are very selfish and I was like, what do you mean by that? He said, yeah, they're selfish. Ask them why they want children. And so I started to go through all these different reasons. I said, well, you know, they want to have children to love. He's like, that's selfish. That's a selfish reason.  That's very selfish. And I want to continue my family name, that's selfish, to take care of me in the future. That's selfish. So everything I was trying to offer, he was like, it's selfish. And then he said something and I'll never forget it. He said, where is the parent who says, I want to produce the next Salah for Dina La Yubi. Where's that parent? That is the intention of parenting, right?  And that really opened my eyes because intentionality with everything that we do, we say Bismillah, with everything that we do, even with when you want to have children. Why do you want to have children? So to see it, that this is an amana from Allah, when he blesses you with a child and to also make sure that you yourself are willing to submit because not everything is going to go your way. There are many people, myself included, I mean, how many of us who had children walked into the hospital with a birth plan, right? My older sisters left the entire time I walked into the hospital. They're like, yeah, good luck with that. Throw it out. It's right. And Dr. Irvin, you know best. Nothing will go. I wanted candles. I wanted soft music. No, no, no. I just was telling Purim in the car. I'm like, I hope I'm not traumatizing. We told her our birth stories of Sadda Fadwa and I.  So you have to be willing to submit. Allah is in control, right? That's a prerequisite of being a really strong mother. And also making sure that you don't allow your enoughs to get ahead of you, right? All of these things we're talking about is making sure that you are in, again, submission to Allah, because Allah challenges us. He says, have you not seen the one who takes his own desire as God? And that's where living in this very materialistic culture, we can get absorbed with the commercialization of parenting. How many people plan more for their nursery and for their photos that they're going to take than actually thinking about, how am I going to discipline this child? How am I going to teach this child? How am I going to put them on the Dean of Huck? How am I going to do those things? Those are the things that should keep us up at night, not where's my photo shoot going to happen, right?  Being dutiful, devoted and watchful, just like a shepherd, we have to be ahead. I can't tell you how many conversations I have with parents who are unfortunately willfully ignorant. They don't want to know certain things. I was just actually speaking with Osada Fadwa as well about some parents who even in the older phases of parenting, you know, they turn a blind eye because it's uncomfortable for them. You know, they don't want to know about what their children are doing online. They don't want to know about the companions that they're keeping. This is very dangerous. It's akin to a shepherd leaving the gate open for the wolves to come in.  The boundaries have to be closed, and that's on you to make sure the gates are locked, right? That's on you. So being watchful, always present, where are my children? Who are they with? Who are they spending time with? This is how the shepherd leads. And then being upright, resilient and confident, very important, as I said, our children, we know this, it's researched, it's very clear. They learn best when you are modeling the right character for them. So you have to make sure that when you want them to have a strong Muslim identity, that you are embracing your own identity. If you're going to tell them to pray, but you don't pray. If you tell them to read Quran, but you're not reading Quran. And these are, you know, I've talked to many teachers of Quran who have these conversations with the parents. Their parents come to complain to them, my child doesn't want to read Quran. He's in a heif's program. He's doing this. He's doing that. She's doing this. She's doing that. And then the teacher will ask them, do you read Quran? I don't know how to. So that's it. Because you don't know how to, you're never going to even try. I mean, think about how, you know, we talk about self-harm as a physical thing. To me, that's soul harm, right? If you do not, you know, understand the weight of not having access to the Book of Allah, as being harming yourself, let's, you know, make that clear right now. And I invite every sister here to never let what we call blame-worthy modesty, right? It's actually a disease of the heart because, you know, modesty is usually this concept that we understand in a positive sense.  If you don't know Tajweed, you haven't learned the Book of Allah, please don't let your nefs dictate to you. You have to say, it doesn't matter if I'm 50, 60, 70, 80 years old. If Allah SWT has given me life every single day as an opportunity, I have to go and be that person who's going to prioritize and make sure that I have that strong identity. So this is how we model. We have the upright, resilient and confidence in our faith, resilience and confidence in our faith. So this is how we shepherd. And there's much more to this, but again, in the interest of time, we're going to move on. And this hadith is really the one that I think every mother holds onto, right?  We can't wait to use this on someone, right? We can't wait. We memorize it. We don't know a lot of Quran, but every woman knows this hadith. And the one about Jannah being under our foot, right? Masha'Allah. It's good. We should know all of these hadith, but we should also know that this is earned. It's not given. It's earned. If you want this status, you have to earn it. And how do we earn it? We have to understand that the Muslim mother is honored and she's honorable, right? So we are honored. Alhamdulillah. We're elevated. Look at the entire seerah of the Prophet ﷺ from the beginning of his mission and to the end of his mission. He was constantly elevating women. And that's why we're here today. Look at us. I mean, honestly, I just, it's so beautiful. I wish you saw what we saw as speakers.  This is such a great honor for us. But we also have to remember that it's earned, as I said. So how do we earn this honor? What does it mean to be honored and honorable? Means being modest in word, in speech, in conduct and dress. Very important because I'm seeing, and this is not to call out any specific generation, but honestly, the trends that we see online are very disturbing to the soul. When you see young Muslims who are very strong and Mashallah, they have passion when they speak. But then in the same breath that they talk about their faith, they will drop an F-bomb. This is unacceptable. We do not curse. We do not use foul language as Muslim women or as Muslims. We do not dress inappropriately. We do not speak about inappropriate things, foul things. We are not vulgar people. We are honorable people. Allah Subh'anaHu Wa Ta'ala elevated us. So we have to elevate our speech, right? And here in the Qur'an, Qada Aflaha Al-Muminun, right? Allah Subh'anaHu Wa Ta'ala says, successful indeed are the believers. Go through all of these. Whenever I read verses of the Qur'an, especially when describing certain groups, we should. This is how we check ourselves. You have to look in your own spiritual mirror and say, do I follow into any of these? Am I humble? Do I avoid idol talk? Am I wasteful in my speech?  Because sometimes we talk about things and we're not realizing that we could be sending someone down a very dark rabbit hole with things that we speak about. You put a plant, a very bad seed, a weed, not a seed, right? And someone's mind. And the next thing, you know, they're going down and searching and looking and now you're going to be held accountable. Why did you bring up that topic or that, you know, that, oh, I watched this movie and now this person's watching the movie. Not only are they watching the movie, they've abandoned their Salah. They've abandoned the Qur'an. So we have to be very careful when we come together to make sure that our speech is valuable, right? That our way of being brings value. And this is how we are honored and what it means to be honorable. And of course, chastity and modesty. This is not just the domain of Muslim women, although it's always seems to be framed that way. Every believer, Allah subhanahu wa ta'ala says, every believer, men and women alike must be modest in dress, conduct, speech, all of that. So this is how we maintain our honor.  When I think of my own journey into motherhood, and I know there's there may be even women here who have struggled with infertility and may have even gone through procedures. I actually know very, very dear beloved people to me who have gone through procedures where the womb, their womb has been removed. And there is this spiritual connection that sometimes we don't realize. It's very real that the word, the womb, right? It comes from the same word, racham, right? As one of the, or the attributes of Allah subhanahu wa ta'ala, ar-rahman ar-rahim, racham. So we are connected very much to our creator through the womb. Whether you're a mother or not, by the way, it doesn't matter if you've never had children or not, you have this capacity, right? And so really seeing yourself as a place of refuge.  We have to also mention this because we're in a time in age where men and women are being constantly pitted against each other. And there's so much divisive language and we're seen as enemies. We're not. We're complimentary to each other. And so we should provide that type of security for one another. But just to have that mindset that if I am to embrace this role of mother, I also want to be a place where my children, my loved ones always feel like they can come back. And so this is where practicing compassion. You may find with your children as they get older, they're going to have struggles. They're going to have questions. They're going to have, they're going to bring up maybe topics that bother you. You know, why don't, don't respond. Why are you asking that?   Because if you don't teach your children how to navigate these, there are wolves and sheeps clothing who are ready to jump on them and take them and consume them. And they will. Eat apart their souls and that's exactly what they're doing. So you have to be that shepherd, that protector, that place of refuge for your children.  And these are very important, you know, concepts again, connecting back to, to our natural disposition as women. We, most of us, inshallah, all of us have these qualities of nurturing and loving and protecting. But it's just really important to see yourself as this in the capacity of motherhood. Now the next slide here also is more on, you know, compassion and building this empathy. I mentioned mirror neurons. If you've heard me speak, you know, I talk a lot about emotional intelligence and, you know, this concept of empathy is the fourth quality of emotional intelligence. It's something we have to inculcate. And this is where, you know, working on your nerves, if you have a hard time feeling empathy for people. That is a spiritual problem because the Prophet, so I said him, was empathic to all creation. And he had empathy for birds and camels and animals. And even Ahud, when he was on Ahud and it started to tremble, right? What did he do? He gently tapped it and said, it'd be calm. So if he can have empathy to the creation of Allah, we have to question where is the empathy within our own hearts. So inculcate these things and make it a priority that you work on your own nerves so that you can, inshallah, possess this beautiful virtue of empathy. And these are just further hadiths, just as reminders of the power of the womb. Don't underestimate the power of the womb. It will in fact be given the capacity to speak like all of our limbs. So when you practice, when you don't practice empathy, and I've seen this, unfortunately, in our community, where relations are cut, people get, you know, done. I'm done with her. I don't want to talk to her. This is not our way. This is not our language. This is not our language to have rifts in families. We should know this is a Qaba'ir. From the 17 Qaba'ir, which are the enormities, it's among the top, to cut people off. So if you know family members, aunts, or grandparents, or whoever, where these things exist, work on softening the hearts, especially as the month of Ramadan draws near, we should really be intentional about trying to remove this break in family. Sheikh Al-Zaynab mentioned this, that this is what this culture aims to do, to divide, destroy families, to break families apart. They would love nothing more than all of us to be cut off from one another. But our Lord calls us to not do that and to actually resist our own nafs and to work on practicing empathy, being understanding that people are struggling. We have so many challenges, subhanAllah. And so again, I'm sorry, I don't know how much time I have left, but just in the last two slides, because I'm sure you can see the theme here. Mashallah, Sheikh Al-Zaynab did much better with bringing her kathiyah. But our hearts, our hearts, where are they? We're here, but our hearts are somewhere else. And so I wanted to just take a moment, because these are the extraordinary mothers that we learn from. Look at their example. Oh, I'm sorry, I didn't change this slide. I mean, I'm sure we saw all of these in the pictures and videos that were coming out. These are the ones that, when I would look at them, my heart.  She shields her children from the harm around her. So learn feeding, protecting, covering, dragging, making da'a to Allah subhanAllah, constantly turning to Allah. This is the mother that we aim to be. Not the mother who, again, is all over social media in her polished, filtered world.  And I'm not judging people. I'm just saying, don't aspire for that. Aspire for the faith of women like this. This is what motherhood is in our deen. And this woman, mashallah. She just took my breath away when I saw this picture. One of my favorite hadith is, al-mu'min, al-mir'at al-mu'min. And it's a challenge, because what it means is that we're supposed to reflect beauty to one another. We're supposed to reflect, and I think most of us, the reason why we're moved by these images is because we see in these women what we hope we have, the qualities that we wished we possessed. So when we see their strength, I mean, she looks like everything that we just talked about, strong, honorable, devout. Look at her hands. I mean, those are the hands of a working woman, right? Humble, courageous, resilient, modest, watchful. So this is the definition of motherhood in our deen. May Allah Subh'anaHu Wa Ta-A'la make us, inshallah, the best of mothers, may He give us strength and help us to raise children who love Him and love His Prophet, sallallahu alayhi wa sallam. Jazakumullahu khayran wa sallamu alaykum wa rahmatullahi wa barakatuh.


Everybody forced here ripping a box of 2022 Chronicles baseball hobby for Bradley are Thanks, Bradley. Good luck. Yeah, we'll know in a few we'll know in a few minutes here, Stefan Secretary we can get through these others Good luck Bradley. Got a Curtis Terry certified rookie Zack Wheeler Jonathan India That third pack is sick I might open that one last dummy thick pack Crawford, O'Neill Cruz Aaron Ashby 1 of 25 on the red rookie auto the blade It's really close for me really I'll go hurt Acevedo just because his floor tire Wanderfranko rookie Trara Titan silver rookie Kevin Smith Yes, Marvin Josh Lowe TJ Friedel origins rookie auto 11 of 25 Yeah, especially the specter ones Joshua rookies and stars looks like a purple Luke Williams Oh, I'm rich right under my thumb 18 to 25 mark McGuire America's pastime jersey card Let's see what's in that dummy thick Look at the size of them Oh Mike trout a Green Connor seabold rookie ticket rookie season ticket 38 of 75 Kareya It looks like a Ryan delayed gold RPA numbered six out of ten You go Bradley Oh, I don't even know if that'll fit in the sleeve There you go Bradley. Congrats on that delayed on the back We'll get that right out to you


Sam here with latent sports cards. We're ripping 22 putting national treasures baseball hobby four box full case break number 23 random team Style there's a look again at your random results as always you can find those on the website under the results tab as well as the Lincoln Shatt We get tiktok set up, and then we'll get going Good luck everybody. Let's do it Okay, perfect. Oh beautiful Ten box Tuesday after this guy still need to fill up optic tiered That's on to four to go and then ten bucks Tuesday basketball. It's down to 13 to go. So we are getting there We are slowly and not slowly. We are surely getting there. So I do appreciate y'all forget now We've got a monster release day tomorrow. We got I'm act baseball player. I'm act basketball plenty of spots available for that As well as impeccable football and flawless baseball. Magic Matt will be doing flawless baseball tomorrow in the morning and the daytime for some doing I'm act basketball and Impeccable football in the daytime, and then I will be doing all three at night. So it's gonna be fun It's gonna be a really good time. We're all really excited for tomorrow. It's gonna be a great release day Here we go. All right, let's do some NT got Reese Nair. That's 37 out of 99 for the Padres Thank you Sean It's fair I live it There's Paul Blackburn 55 out of 99 for the ace. I do appreciate that. Thank you That's one there for the ace. We've got going to the Blue Jays Roberto Alomar 32 out of 49 retro materials That's cool game more on that one as well on the Alomar First auto is gonna be Brendan Brendan Beck going to the Yankees 10 out of 99 on the prospect auto Patch auto. I should their Jersey auto. I should say prospect Jersey auto Followed by a on card auto 82 out of 99 of a Dolos Garcia for the Rangers. Nice one there, Texas Tejas picking up a nice one Trout auto coming. I'll be so awesome. Rah We've got nice one here thick is gonna be 22 out of 25 Henry Davis on the future auto for the Pirates nice one there Pittsburgh Magnus next one Nasty congrats Pittsburgh. That is Yahweh T Nice one here to 99 three colored RPA Seiya Suzuki Boom, that's going to the Cubs congrats Chicago Cubbies is gonna be Jonathan B. There you go, buddy. Nice one there is a view of it for you tiktok awesome hit Congrats on that.  That's cool. Adrian W. Jacob love this card They could be biting a shirt right good chewing through the garbage can Legitary material signature 16 of 25 is Roger Clemens Nice that is Yankees Roger Clemens. Wow Okay, grads Daniel V on the rocket The rocket going to the Yankees Sean's favorite team right there As a matter of fact garbage team Got you guys the link to optic tiered for to go next break. We got a fill up is couple basketball breaks These I believe are 590 a box, but this is a group break right here So it's like $80 a spot for a random team bruise dark rater all to 99 of 99 for the Dodgers by Colossal Jersey, that's gonna be Bobby doll back to 99 Next one's really cool. This is gonna be a field pass of satchel page 10 of 15 Game-worn satchel page great hit there congrats First auto is gonna go into the age. Shea Langlears 23 out of 99 on the clutch factor Jersey auto prospect auto I should say Very nice followed by going to the Yankees 4 of 25 Louise Heel That's Jersey two-color patch The Yankees nice one there for the Yankees upside down is one. Yep as 21 out of 99 on card rookie auto for the Cardinals There you go, St. Louis Followed by 26 out of 49 is three-colored RPA Connor Wong Nice one there red socks nice RPA Horizontal that is the true in MC baseball Luke taking that 10 bucks Tuesday football spot Nice one here back-to-back hits for Boston. That's gonna be Jim Rice 21 out of 49 For the again red socks that is on car to game use bat all of the materials and we've got to end it 29 out of 40 Mike ish Kremsky on the jumbo material signature for the Giants Is game-worn game-worn. He has nice one there They should make a dual auto of him and Carl. I don't know if that exists already, but that'd be cool I'm sure that already exists Does anybody know that so many know if there's a dual auto of Mike and Carl Yastremsky That'd be cool if there's not, but if there is then I guess I'm just late to the party Trash apparently Although slider boxes we save coming in handy now aren't they? Those are garbage steam yeah, those are steamers right there Corbin Martin for the Diamondbacks seven out of 25 Colossal jumbo patch probably going to Cardinals that's gonna be a Dylan Carlson 95 out of 99 next up we've got going to the Giants That's gonna be a Bobby Thompson 27 out of 49 Giants legend right there game use bat Yes, that is a game use that Really come on here century auto 10 out of 25 the Kraken. That's gonna be Gary Sanchez going to the twins Yankee legend Yankee legend that is Gary Sanchez Wow We've got ten bucks Tuesday baseball next which is like a Bowman mixer Really cool Bowman mixer We do this. No, that's wrong next up. We've got RPA is gonna be recent there three out of 25 for the Padres three colored RPA rookie silhouettes I just want to hear that Yankees 39 out of 49 Alfonso Soriano That's cool. Yeah going to the Yankees. That's awesome that game use yes It is game-worn Jersey on card auto Such a beast for the Yankees Stop we've got four colored RPA 46 out of 99 for the Giants Camillo dull That's James P with the Giants on that one Sorry, James Nice one here 20 out of 49 big poppy Let's go go into the Red Sox. That's on-card Jersey auto Game-worn to nice congrats big poppy We've got on the back is treasured stats 34 of 70 mark McGuire 70 home runs For the Cardinals get like one of these per case, which is kind of nice. They're a little bit shorter printed and 36 out of 99 dual memorabilia signature set beer that is Jersey and three-colored patch for the Diamondbacks So I'm there when he's down for a set beer. Oh Delicious Beer and a Jake burger right at last box of the case. Good luck everybody. We'll do a quick recap after as well We got a pleat One yep, that's to 99 89 of 99 you really gonna Printing play three-color patch tie France one of one for the Mariners nice one there Mariners 28 out of 49 is Jose Ramirez That is player worn for the Guardians This one here 45 out of 99 Thomas the pucky. That's going to the Metz 45 again That is rookie silhouette Jersey auto that's Matt's That night. Yeah, it's just like part of the patch. Yeah Yeah there's a Willie Castro For the Tigers someone say Landry fields Yeah, we mentioned a random role-player and spawn spawned into the stream What's it up forest goes good afternoon fellow Keon dueling collectors earlier today? We've got going to the brewers. That's gonna be Aaron Ashby signatures names hashtag. This is my crew 47 out of 99 next up We've got five out of 99 that is going to the White Sox roaming Gonzalez. Oh, that's so nasty This next one's so sick, dude Who's got and we got going to Adrian W? 23 out of 49 Wander Franco And then it is the signature name is El Patron El Patron Congrats, there you go Adrian nice wander RPA that is on card and a live wander Very nice. We'll get that mag for you, buddy. That is fantastic fantastic So we've got JT Schwartz Two colored patch auto for the max To 99 74 out of 99 going to the Dodgers legendary materials to a five Jim Gilliam Jim Gilliam nice one there. That is game used. I believe yes, it is Brooklyn Dodgers Awesome card love these like historical that they put in the old players and such. It's so cool. Awesome All right, that'll do it for the break everybody empty empty do a quick recap here start with our Memorabilia cards Jose Ramirez guardians one of one's high France Mariners Juan Yep as Cardinals Bobby Thompson Giants Dylan Carlson Cardinals Corbin Martin for the Diamondbacks Roussard Grader all Dodgers Bobby doll back Red Sox satchel page That is Roberto Alomar for the Blue Jays Paul Blackburn A's and Reese Nair for the Padres do booklets next We had Jim Gilliam for the Dodgers Seth beer Diamondbacks Mike Yastremski Giants and Roger Clemens for the Yankees Autos now we've got JT Schwartz Mets Romy Gonzalez for the White Sox Aaron Ashby Brewers Willie Castro Tigers Thomas a Pucky Mets Big Poppy for the Red Sox Milo Dove all for the Giants Alfonso Soriano for the Yankees Reese Nair Padres Gary Sanchez twins the Kraken Jim Rice Red Sox Connor Wong Red Sox Juan Yep as Cardinals Louis heal Yanks Shane Langlears for the A's Shane Boz rays Jack Jack Lader for the Rangers Henry Davis Pirates Adolis Garcia Rangers Brandon Beck for the Yankees To Mag Cards we add to 99 say a Suzuki going to the Cubs on the RPA three-color and The hit of the break El Patron 23 out of 49 wander Franco for the Rays Congrats again to Adrian with the Rays I'll do it for the break guys. Thanks again for the fill next up. We've got ten bucks Tuesday


Wel, yn y toffi TV ydy'r Eftan News Daily. Marcell Brands has rubbish rooms that Eftan have been quoted £40 million for Monaco Midfielder, Alexander Goverland. Brands apparently gave a quote to Sport Express website saying that simply isn't true. It said the fee is nowhere near that, but didn't confirm whether Eftan were actually interested in the Monaco Midfielder. He had apparently spoken to another news outlet last week and said they haven't been interested in it, but this report continues to link Gullivan with a move to Godderson Park. Rafa Benitez does want to strengthen his squad ahead of the January transfer window, looking likely to be loaned at teams at this stage, but Gullivan is a name that has been mentioned a few times, but apparently that fee is far too high and rightly so as well. On the back of that, there has been a report in the Daily Mail today which has made some assumptions from football clubs as to what they could have to spend in the January transfer window. Everton unsurprisingly had the least amount. In fact Everton had minus 35 million according to a report done by Cairyn Maguire. It was a finance expert. Everton have been up against the wall for a while. I think we all know that it was proven in the summer when Everton only spent 1.6 million, but there was some money to spend there. It wasn't spent and you would like to think that that would be spent in January. The thing about these assumptions is he hasn't got all the information. I'm not saying Everton have got loads to spend and he's got it all wrong because I simply haven't got a clue, but it would suggest that Everton can make moves in terms of loans and stuff in January and I think that's what he would have been moving towards anyway. But I think the reality is for a lot of people it's hit that we've made some big errors and we're paying for them and probably without a big sale then there'd be no big transfers in unless the current rules change. Everton are hoping for is for a rule change to use more of the owner's money, but that isn't forthcoming at the minute so you do have to play by the rules and that's what it is. Those rules are there to be seen and Everton have suffered loss. There's been some terrible errors in the transfer market and we have to simply get better at that and this highlights that again so we're going to have to be creative again in the January transfer window like I said, loan moves and also Everton need to be targeting free transfers. Some good players out of contract next summer, the blues I think in my opinion should be going after a few of them trying to get them on pre contracts ahead of next summer because we do need some better players in our squad and if we haven't got hundreds of millions to spend on it then you've got to be creative and do it. But this summer has shown that you can get some good players who are out of contract if you move quickly so hopefully the recruitment team are doing that and we move on it because it's what we need. Anthony Gordon scored twice last night for England under 21 side as they defeated the Czech Republic. Great to see the young Everton winger getting off the mark. It was a debut for the under 21 side so the score 2 is brilliant. He's awaiting his first Everton goal and I think when he gets that it's going to be a great day when he gets that for Everton. He's been excellent this season. He's really improved under Rafa Bonitas. He's really took on the tactical side of the game. He's working harder and he's becoming a player that Evertonians want to see in the side and if he can make himself the first sub then he's doing really well. He's not in the team so long may that continue. The expectations we have to keep them down a bit but he's doing well so hopefully he will continue to do that.  They drew Nillnill with Portugal and a Well Cup qualifier and tonight Jordan Pickford should star for England against Albania in the Well Cup qualifier at Wembley. So good luck to Jordan there. That is the news daily. Give the video a thumbs up, subscribe if you haven't and if you want more exclusive videos join us on Patreon. Have a great weekend. See you later.


Uh-oh, Forrest just messed up. What's going on, everyone? Sam here with late in sports cards. We've been 23, Top Star Wars, Chrome Black, Obby, 12 box case number three, random auto or pack style. Gonna do the random now. We've got 24 participants, and then we've got autos 1 through 12, packs 1 through 12. Roll the dice. Gonna go on each four times. One, two, three, and four. Matthew S, down to Lauren C. And four times. So, Rob, how you doing, buddy? Four times on your autos and packs. One, two, three, and four. Auto 11, down to auto 12. Be these in. Matt S, with auto 11. Greg M, pack three. Jonathan L, pack six. Rudy S, auto four. Mike I, pack eight. Scott N, auto nine. Hoy P, pack 11. William M, auto six. Matt P, pack four. Greg M, pack one. Matthew S, pack 12. Sean Z, pack 10. Francis D, with pack seven. William M, auto two. Francis D, auto 10. Mike I, auto seven. Scott N, auto, no. So, Mike I, with auto five. Scott N, auto seven. Greg M, auto eight. Francis D, auto one. Jonathan R, pack nine. Hoy P, pack two. Victor F, pack five. Gavin K, auto three. And Lauren C, auto 12. So, let me get these copied over really quick. I'll open the case and we'll get going. Again, we've got eight to go on the next one, everybody, eight to go on the next break of this. Results four. Guys, this is Link. Let me get these organized. Large and in charge, I love it. I love it, Rob. Again, everybody, how about eight to go? Oops, eight to go in the next break. Again, fiftieth spot. Andrew B, with the White Sox and Sterling and tier one. Okay, so, open the case. Boxes one through six, seven through 12. Again, the number at the end of whatever auto or pack you have corresponds to the box. So, auto one would be from box one, obviously. So, the box is one through four. One through four right there. Five and six on the bottom. So again, we'll do that. Do that. One through six and then seven. Empty case. Here we go. So that was box one. So we got Francis D, auto one. Greg M, with pack one. Yeah, I got you, Greg. No recap on these, obviously. All right, pack one. Good luck here, Greg. Let's see it, buddy. That is gonna be Lando Calrissian. Bix Kaleen, two, one, nine, nine. And the refractor, nice one there. Blasio, Blasio. Thank you. Blasio. Thank you. And Darth Vader, nice one there as well. Congrats, Greg. Auto one, going to Francis D. It's gonna be FN 2199. That is David Accord, the voice of. All right, box two. We have pack two, Hoipi and auto two, William M. Zory Bliss. Fantastic fights of Mace Windu and Chancellor Palpatine. And Janna. Or Janna. We've got auto two is William M of Officer McKay. Mark Capri, Officer Mkay. Mkay. All right, auto three. Gavin K, pack three. Greg M, the main com. Don't panic, it's just my go-for-the-vanic. All the Rangers got out of that. Yeah. Wow. Good Lord. All right, we got Tion Medan. Janna to 199 on the refractor. Nice one there. And Luminara Unduli. And Gavin K with auto three is Minus Velti. Nice one there, Ming Chu. I know we saw, we saw Rob. It's sad, man. Jonathan with another spot, we're down to seven. Andrew with Georgia in the next, in Bowman Chrome U. Thank you all. All right, number four now. So we've got auto, or pack four, Matt P, auto four, Rudy S. Seven to go in the next one, everybody. Seven to go, ladies and gents. Is Jack Porkins. Darth Maul. Nice one there. And Purple, Jar Jar Binks to 125. What's your favorite character, all right? Jack Porkins looks like Jake. And we've got a green auto to 99 of Tuscan Chief. Tuscan Chief, Javier Jimenez. This is Tuscan Chief on the green. All right, box five. Pack five, Victor F, auto five, Mike I. Sputtering. Nice, I think we got a red. Throw that to the back. Jar Jar Binks, Vicks Kleen to 125. And, or it might be a few shots. You 10 is Babu Frick. Nice one there. Babu Frick, three of 10. Going to Victor F and pack five.  That's fire. And green auto of Wade Reselyan to 99. That is Ryder McLaughlin. I knew Forrest would like that one. Forrest the big Babu Frick guy. And on to number six, Jonathan L at pack six and auto six, William M. Babu Frick. What do I see, everybody? Like orange. Nice. Momon Nadon to 99 on the green. Blue, Janna to 75. My best Babu Frick impression. Cassie and Andor. Donate all my cards to Forrest. 225 is Klattu. Nice one there. Corey D. Williams as Klattu on the orange auto. Going to Jonathan L. Congrats, Jonathan. Matt P with a spot. We are down to six in the next one, everybody. Six to go in the next Star Wars. Number seven, we've got auto seven, Scott N, pack seven, Francis D. Seven, eight, nine, 10, 11, now we're on seven. Again, pack seven, Francis D. And an orange on the back here. That's Maul. Jar Jar Binks to 199. And orange, Beru Lars. That is a new hope, Beru Lars. 225. And auto seven, Barris Offi. That is Nalini Krishan. As Barris Offi. You good? I'll give you a sec. Hey, you're good. Again, Flux down to 12 to go. That Star Wars is sold out. Six to go, breaks next Star Wars. That was... All right, we got box eight. Auto eight is Greg. Pack eight is Mike I. Yes, pack eight. That is gonna be Babu Frick. Gold Bosk. That's sick, dude. I love Bosk. 49 and 50. Which word would I rather become widely used again? Fisty Cuffs or Tusk. I like Fisty Cuffs. Mace Windu Django Fett. And auto eight going to Greg is Toro Callican. That is Jake Cannavale, or Cannavel, as Toro Callican. That's one there. Number nine now, everybody. Pack nine, Jonathan R. Auto nine is Scott N. Love guys. It is Dormit. 2199, Nian Nub. And Ahsoka Tana. That's one there. And Scott at auto nine is Cousin Niano Organa. That is Ian Ingo, as Cousin Niano Organa. Let's go Rob with two spots. Hell yeah, Rob. Jacob with two spots. We're down to two all of a sudden, everybody. Two to go. Four spots have disappeared. Two to go on the last Star Wars break of the day. All right, on to the double digits now. Pack 10, Sean Z, auto 10, Francis D. I'd like to challenge you to a Tossel. All right, I'm in. Illegal. I agree with that. All right, Cousin Andor to 199. Green to 99, Body Rook. Nice one there. And a Nian Nub base. And auto 10, Francis D. We've got Crescentin. It's for a skin and fortnight right there. Crescentin. Very nice. Auto 11, Matthew S. Pack 11, Hoypee, Han Solo. Luminara Unduli to 199, Refractor. And Fantastic Fights of Rey and Palpatine. And auto is Taladirth. That is Indira Varma as Taladirth. There you go, Matthew. Pretty nice pack there, Hoype. And pack 12, Matthew S. Auto 12, Lauren C. Good luck here, everybody. I've been at fist fight, yes, I have been. Yes, I have been. And I've taken many punches to the face in boxing. Admiral Ackbar. Fantastic Fights, Luke Skywalker and Darth Vader. And Bix Caleen, or Bix Caleen. Nice one there. Me and my buddy, when we work out, the last thing we'd have to do is both take an uppercut to the jaw from each other. Really? Yes, like as hard as you could, you know.  And it is Handmaiden Agira. That is Molly Miller's Handmaiden Agira. Auto 12, going to Lauren. Scott N, selling us out, thank you Scott. Okay, sounds good, Greg, I got you. That'll do it for the break here, everybody. Thanks again for the fill. Coming up next is number four.


The National Parliaments are behind the EU curve in a number of ways, first with regard to legislation, because a lot of legislation is negotiated in fact between the European Parliament and the Council of Ministers, representatives behind closed doors in trial meetings before there's even been a first reading in the European Parliament. So it's very difficult for National Parliaments to know what the state of the negotiations is while negotiations are ongoing. So it changes from the drafts that they've originally seen, but recently it's also behind the curve in terms of different kinds of powers that have been given to different executive actors at the super national level, such as the Commission with regard to the European semester and also, for example, the European Central Bank. As well, and I should mention the European Council, which is crucial in terms of taking leading decisions in the European Union, often they are not informed on time the nature of the discussions that will take place in European Council meetings and are presented with decisions afterwards. I think given the manner in which the European Union is evolving, that it's neither only super national or only intergovernmental, but is a complex mixture between the two. It's crucial that the Parliaments across those levels, so both the European Parliament and the National Parliaments, cooperate together. And I think it's happening to some extent already, but it can be intensified either through inter-parliamentary committee meetings, which are happening more and more often also at the initiative of the European Parliament, but also national members of the European Parliament attending national parliamentary committees to give information and have a dialogue at crucial moments in either the legislative process or in other non-legislative processes, such as the European semester. I think there's a number of things that National Parliaments can and in my view should do themselves. First, they must insist vis-a-vis their own government that they are fully informed as to the decisions that are being taken at the European level. They should have access to the databases that the government has, the European level database that the government has, so that they have all the information they require. That's one thing that they can attempt to do. The Germans have recently adopted a very far-reaching law in that respect that obliges the government to give that kind of information to the Parliament. And that could act as a model. That's one thing that National Parliaments can do themselves, but also I think they must increasingly engage with the supranational actors and also invite the presidents of various key institutions such as the European Council, the Commission and indeed the European Central Bank to come to them and to give them information and to engage in a dialogue with them. This is being increasingly done and I think this is an element that can be developed further.


Thank you so much. Hello, I'm so glad to be here. Today I'm going to talk about how to characterize immune cell tumor infiltrating and lymphocytes using our sick data. Okay, as we all know, as we all know, tumor developers in a complex dynamic microenvironment, tumor cells are in close relationship with diverse non-tumor cells within this environment. Then tumor cells has ability to shape their microenvironment to satisfy the metabolic and immunological needs. And to fight this ability, lymphocytes are recruited into tumor to kill tumor cells and control its growth. Interaction between tumor cells, can you still hear me? Okay, the intact, the intact, the interaction between tumor and the host immune system critically affect tumor development, progression and prognosis. So the prognostic, predictive and therapeutic values, I'll just talk about. That's the one that's actually on right now. Hello? Okay, it sounds better. Okay, a few studies have showed that the presence and amount of tails is associated with clinical outcomes. So people have been looking at the tails from different points of views. I do have to mention three great studies. The Ronny study quantified the immune satellite activity based on expression of two satellite effectors, GZMA and PRF1, across 18 tumor types. Their bandage paper characterized the immune landscape in 107 CRC patients by analyzing 28 immune cell types. Their angeloid paper characterized the immune phenotype and antigenome of about 600 CRC tumors. There is also a poster by Yashin, the group profiles the infiltrating levels in 19 tumor types by mRNA based T cell infiltration scores. We have been looking at tails from another different point of view, the expression of T cell and B cell receptor. We are now building our automated data analysis pipeline using our SIG data. So our pipeline, how to get the point out? Okay, so our pipeline contains three modules to characterize the expression, colonality, and the diversity of T cell receptor and B cell receptor to estimate the density, composition, and phenotype of the infiltrating levels of immune cells, get a complete picture of the immune signatures that integrate with the mutational signature and clinical outcomes to finally get a list of genetic factors with prognostical values to predict patient's outcome and to direct immune therapy. So today with, in the 15 minutes, I'm going to talk about this part, how to characterize tails using as an expression of T cell receptor and B cell receptor using our SIG data. So I will show you some of the preliminary data on TCGA, colon adenocarcinoma, and the testicular germ cell tumors. So please allow me to give you a quick background about the piece about B cell receptor and T cell receptor, BCR and TCR. They are antidein receptors expressed on the surface of the material T cell and B cells. So in about, oh, sorry, in about 95% of the T cells is expressed, it's composed of a different protein chains, alpha-chain and beta-chain, and the B cell receptor is composed of two identical light chains and heavy chains and light chains. The B cell receptor and T cell receptor genes are located on different chromosomes with different orientations, as you can see here. So they are all big in size and they have complex gene structures. So the smallest one is a T cell receptor beta is located on 7q, it is about 0.5 megabases, has 85 gene segments, and the longest one is a B cell receptor, the copper chain. So it's located on 2p and it's about 1.5 megabase in size. So here is an example, it shows you the structure of T cell receptor with beta. So a T cell receptor with beta is the most studied T cell receptor because it is the simplest in this gene structure from to, oh, sorry, from 5 to 3 prime, you can see there is a variable gene segment, about 50 variable gene segments, the green boxes indicating the functional gene segments, the yellow one is the open reading frame and the red one is the sealed genes. After that there is several genes, they are non-related genes, they are in purple. After that is a diversity region one, the joining region one is contained of our six segments, the constant region one and the diversity region two. Joining region two consists of eight gene segments and the constant region two. This variable gene segment is located at the end. So the somatic recombination is a process is occurred at the very early stage of T cell and B cell muturation. This unique process ultimately results in a new amino acid sequence as a, as an independent region of B cell receptor and T cell receptor. This unique process also leads to a T cell and B cell receptor with great diversity. So here is a picture, example to show you a picture of the diversity of T cell receptor beta gene expression. So the left, the left hand is that we beta, the right hand we alpha is for some CRC patients. As you can see here, some patients, there's a high level expression of, of TCR and you can see many segments are expressed and some of the patients quite, there's a fewer patient, a fewer segments got expressed and the expression level is relatively lower and in some patients the expression is fairly detectable. We quantified the expression of TCR and BCR using R6 data. We count the number reads mapped to each gene segments and normalize it with sequencing depth and gene length. We also examined the TCR and BCR clonality by analyzing the soft clipper reads mapped as, mapped as rearrangement breakpoints. On the left hand, the uniformity of the soft clipper reads indicating this is a single T cell clone and on the right hand, all the soft clipper reads are different. This indicates a polygonal T cell raptor. Before I move to TCG data, I'm going to show you a few examples of the TCR and BCR expression in lymphoma patients. Here is a picture of TCR expression in T cell lymphoma patients. It's a small patient cohort. The first five samples are controlled T cells from healthy donors. As you can see here, for most of the patients, there is a clone expansion of one or two T cell receptor genes and a few samples, one or two, show the polyclonal signatures. Here is another example of the BCR expression in a B cell lymphoma patients. You can see a clone expansion of a miniglobin-heavy Chen gene and two Kappa Chen gene, which is consistent with the lab test. But with RNA-seq data, we are also able to detect expression of the lumped Chen gene. You can see the expression level is right or lower compared to the Kappa Chen gene about 10%. But we are still able to see it. So with these examples, I'm trying to see a character of T cell and B cell receptor expression with RNA-seq data is sensitive and is very accurate. Also with RNA-seq data, we can look at the entire T cell receptor in these B cell lymphoma patients. As you can see here, this B cell lymphoma patient actually has a polyclonal T cell receptor RNA-beta raptor, which products are good prognosis for treatment. Okay, now move to the TCGA data. I show you a selected subset of CRC patients. So from this, this is a seporized head map clustering of the expression T cell receptor, both alpha and beta. As you can see here, first, the expression of alpha and beta are pretty consistent. The patient with high expression of alpha had higher level expression of the beta. So this is expected because alpha and beta should always be expressed together. The second, you can see the expression of T cell receptor with alpha and beta are associated with macro satellite status. So as you can see here, the hyper-muted patients, they are MSI positive. So indicated by the red bars and the ultra-muted patients, those patients have a mutation in the external nuclear domain of the pole E. So they are hyper-muted. These patients, they are tightly clustered here. They have a strong expression of T cell receptor, both alpha and beta. Also, of course, there are some patients clustered here, so low expression of these T cell receptors. Here, the expression of B cell receptor, the heavy chain, the carbon chain, laminar chain expression are pretty consistent. But as the association of B cell expression and the micro-satellite status seem like it is weaker, because you can see almost half of the patients in this cluster and half of the patients in this cluster, they are micro-satellite stable. With this summary graph, it is more clear. You can see for the T cell receptor expression, the micro-satellite stable patients, about 30% of the patients press TCR. The hyper-muted patients, about 80% of the patients press TCR. The ultra-muted patients, about 60%. That's actually a significant p-value between these two groups. But we didn't see any difference with the current data set for B cell expression. So we try to characterize the two sub-populations.  We got the metagenes from two literature, two papers. The G-list 1 is 812 genes for 28 immune cell sub-populations from Angelova's paper. G-list 2 is 507 genes for 25 immune cell sub-populations from Bandit's paper. So I have to note that there is a little overlap of gene 1 and gene 2, 14 genes are common. So for our analysis, we use both gene 1 and gene 2. So here is the integrated view of expression of the T cell receptor, B cell receptor, the metagenes, 1, metagenes, 2. So this head map is kind of complicated, but first there, we see there's a small group here, has a high expression of T cell receptor, B cell receptor, and a strong expression of these metagenes. This head map review interesting our patterns. First, this group, about half of the patients, this shows low-level expression of T cell receptor and B cell receptor. But there is a higher level of expression of these metagenes. And this cluster, those patients express both T cell receptor and B cell receptor, but it's low-level expression of these metagenes. So there is two questions. First, as this metagene really immune cell type specific, could this also be produced by net immune cells? And the second, for these patients, are those T cell and B cells with expression of the receptor are they functionally normal? Why there's no expression of these metagenes? So we have to do further analysis to answer these questions. Okay. So we also tried to look at association with clinical outcomes for this small selected data set, but since there are only about half of the 60 patients has available clinical data, so we don't have enough power to see any association with the clinical outcomes. So now the TGCT data, the test killer germ cell tumors, we have 138 patients with clinical data. So here I show the expression of T cell receptor, alpha and beta is like CRC, the expression is pretty consistent. And also you can see those green bars, indeed, is nanderminomers. So the expression associated with histopathology subtypes, the nanderminomers has a lower expression of T cell and B cell, and the germinomers, they are two clusters, has a higher strength expression of T cell receptors. The similar pattern for a B cell receptor, there's two, the seminomers has a higher expression. So with this summary paragraph, you are about to see that there are T cell and T cell and B cell expression is associated with subtypes. So the seminomers are 90% of the seminomers express T cell receptors, and only 70% of the nanderminomers express the T cell receptors. But also we see this pattern with B cell receptor expression. So 87 patients have clinical outcomes. So I think I might choose the wrong tumor type to look at the clinical associates because generally the TGCT patients have a wonderful response to either radiotherapy or chemotherapy. So these 87 patients, only 11 of them either show the partial remission or progressive disease. So it's hard to tell, but you can say about 9 of the early patients are in this cluster with relatively lower expression of T cell receptors. So here's a summary figure. Actually, we can see there's some significant difference between these two groups. The patient with complete remission has a higher level of T cell expression, but we didn't see this trend with the current data for B cell receptor expression. So we try to correlate with a metagen expression. So here's a summary hit map. First we can say there's a subset of patients has high expression of T cell receptor B cell receptor, also the metagenes. But you can see there are two small clusters here. So in this patient probably there's a stronger expression of TCR, weak expression of the BCR. Probably the immune cell infiltration in this subset of patients are T cell lineage dominant and in this subset the B cell lineage dominant. But we can still see these patterns. There are two big groups. There's no expression of T cell and B cell. They are expression of these metagenes. So we have to look further into it to answer these questions. Are those metagenes really produced by the T cell immune cells? So a summary of my talk today is I try to show you I accidentally hit some button. I'm sorry. So the presence and density of tails can be estimated by analyzing the TCR and BCR gene expression using R6 data. And the TCR BCR expression profiles are associated with molecular phenotypes and treatment outcomes. So for filter directions so SRT, so we are going to expand our analysis to the Pankham project data comprehensive picture of immune signatures in major types of human cancers. And we are going to correlate the immune signature with the mutational signatures to get more insights. So I'd like to thank Kyle and Liu for helping with the data download analysis. I'd like to thank David and Richard for their support. Thank you so much for your attention. Well that's a quick one. Maybe you said this but in that analysis where you see different amounts of expression for different subtypes. Are you able to control for the handling of the surgical sample? In other words tumor purity as well as the way excision has been made is if excision was made that might inform in part about the difference that you see. So tumor purity and handling of sample does it have an influence on your expression patterns? That's a good question. Actually we presumably we think the level of BCR and TCR expression will correlate with density of infiltrating T-cell and B-cells and we tried to correlate our expression data with a pathology report and the percentage of T-cell and B-cells. It seems like there's a nice correlation but I didn't show the data here. So I was really struck by the correlation of high TCR expression with the hypermutated subtypes of colon cancer. I thought that was a fascinating result. I guess this is more of a comment. I think it'd be really interesting to apply the approach you've taken here to data sets with response data for immunotherapy and so I see Caroline. I'm not seeing I see JC and I don't see Lou yet but I think this would be something really interesting for the NIH to think about as an important area for the future. Thank you. This is a good suggestion. Yeah we think this our profile will be very helpful to guide to pretty patient outcome and to guide immune surface. Thank you very much.