Okay, well first of all I wanted to say how incredibly exciting it is to be here to help celebrate the 10th anniversary of the completion of the Human Genome Project, and I'm here to tell you a bit about how that's impacted my research personally, which is focused on human evolutionary genomics. So I thought I'd start out by talking about what I envision as some of the key challenges in human genomics research, now 10 years later after the completion of the genome project, and that includes better understanding of how the extent of the genetic variation and phenotypic variation that exists across a broad range of ethnically diverse people across the globe, and we're just at the beginning stages of understanding that. Secondly, to better understand what are the evolutionary processes generating and maintaining that variation, and lastly how to gene-gene, gene protein, and gene environment interactions contribute to phenotypic variability in humans. Now the focus of my research is on Africa, and there's a number of reasons for that. First of all it's thought that all anatomically modern humans originated in Africa about 200,000 years ago, and here these red dots are representing sites where there's fossil material for the earliest anatomically modern humans, and the oldest fossils are found in southern Ethiopia, dated to about 150,000 to 195,000 years ago. We also have evidence for very early modern behavior. This was an example of carved ochre found in southern Africa, dated to about 70,000 years ago, but there's been some more recent findings that are dating this back even further, maybe 120,000 years ago in South Africa. So it's thought that after anatomically modern humans arose in Africa about 200,000 years ago, there was a migration of very small numbers of people, was not too large, that then migrated across the rest of the globe. And so because it was a small number of groups of people leaving, you can imagine that outside of Africa there tends to be a subset of the genetic variation present in Africa, although of course, since this was approximately 50,000 to 100,000 years ago, there's been time for genetic variation to accumulate in other regions as well. So the pattern of genetic variation that we see today is going to be a reflection of our evolutionary and demographic history. If we were to look at identical twins, we don't see any differences. If we look at unrelated humans, there's about one nucleotide difference out of every 1,000 base pairs. And if we look at human versus our closest genetic relative, the chimpanzee, from whom we, our ancestors, diverged about 5 to 6 million years ago, it's about 1 out of 100. So since there are 3 billion DNA bases, that comes out to about 3 million differences between each pair of genomes. But there's a lot more to be learned, particularly about structural variation, like insertions and deletions, duplications and inversions. We are just at the beginning of characterizing that extent of variation, particularly across diverse populations. But all the studies have shown that generally, most of the variation that exists is within populations relative to between populations. And that simply reflects our very recent common ancestry within the past 100,000 or so years. So why are we particularly interested in studying Africa? Well one, if we want to learn about human origins, we need to go to the homeland, the birthplace of modern humans, which is Africa. If we want to learn more about the African diaspora and African-American ancestry, we need to be looking in Africa. Africa is also a region of very high prevalence of communicable diseases like HIV, malaria and TB, but increasingly there's a large prevalence of non-communicable diseases like hypertension and diabetes and so on. So if we want to understand the risk factors for these diseases, we need to be looking in Africa. And then lastly, as you heard from Dr. Green, there can be differences in how people respond to drugs. And those may be due to variation at drug metabolizing loci, and we need to have better characterization of variation in Africa to develop better treatments. Now despite the importance of studying African genomic variation, there has been relatively little work done in that region. And so for that reason, myself and my students and my collaborators in Africa have been going to Africa for over 12 years to do field work. We mainly focus on minority populations. These are groups that are otherwise not really being studied by biomedical researchers and they have very limited healthcare access. And for these we've collected now over 10,000 samples from blood. For many we have RNA, for many we have frozen plasma. And we get very detailed ethnographic information and information about things like diet and nutrition. I also want to point out that this can be exceedingly challenging work to do in the field. And we've actually spent a number of years developing these methods in our lab in the U.S. before trying to bring this to the field. Also equally important is training and capacity building in Africa. I've personally trained a number of African students in postdocs and one of the major goals of the H3Africa project, which is being spearheaded by NIH, is to do exactly this. And hopefully it's going to have a major impact on training and capacity building to do genomics research in Africa. And lastly, I can't emphasize enough how important I think it is to actually return results to participants. People rarely do and I can tell you they really, really appreciate it when we go back and they're genuinely interested in knowing. So while we're there, we're also not only collecting biospecimens, we're measuring phenotypic variation. Things like detailed anthropometric variants like height and weight, percent body fat, skin pigmentation. We're measuring cardiovascular lung and blood phenotypes. We're studying metabolic function and that will be informative for learning about adaptation to diet. And we're studying infectious disease status and immune response. So just to give you an example of how much phenotypic variation do we see? Well, this is from a study we published about a year ago and we're showing a strong correlation between hemoglobin levels and the altitude at which populations live in Ethiopia. So these are the high altitude Amharic populations and then these are lower altitude. We identified genes that are targets of selection and are associated with hemoglobin levels and they seem to play an important role in the HF1 pathway that is critical for hypoxia, response to hypoxia. Another example, people rarely realize how much variation there is in skin pigmentation in Africa but we see a tremendous amount that is not only interesting from an anthropological perspective, it's an adaptive trait but it also is going to influence things like vitamin D levels and perhaps folate levels as well. So there can be biomedical implications. These are principal components analysis of some cardiovascular traits and these were taken in Kenya and these are color coded by ethnicity basically or language family. And the point is you can see that people are clustering, groups are clustering by shared ethnicity generally with one exception showing that there are probably not only genetic but also environmental factors because these groups live near each other in regards to cardiovascular traits. We're also now starting to look at both directed and undirected metabolomics from plasma obtained from blood together with Charles Burant at University of Michigan. This is from 1,000 metabolites and we can see significant differences between populations that have distinct diets. So I want to tell you a bit about our study published a few years ago in which we characterize a broad range of genomic variable sites across the genome in over 2,500 Africans from 121 ethnic groups and in 98 African Americans from four regions of the US and then we had a comparative data set of more than 1,500 non-Africans. Here's the distribution of the populations we studied. It's pretty good but there are a lot of gaps as you can see and there's a lot more work to be done because there's over 2,000 ethnic groups in Africa. So first I'm showing you here the levels of genetic diversity in orange of the African populations and as every study has shown the highest levels of variation are in Africa and then we see decreasing variation as we move west to east across Eurasia into East Asia, Oceania and the Americas and that simply reflects our demographic history, series of founding events as we migrated out of Africa. This is looking at a principal components analysis based on individual variation. So each circle here actually represents a person and if they are genetically similar they are going to cluster together and the first principal component is distinguishing Africans from non-Africans. The second is distinguishing Native Americans, Eastern Eurasians and Oceaniens from the rest and the third principal component is distinguishing a very small hunter-gatherer tribe in Tanzania called the Hadza which we have been studying. We then use an approach which basically called structure which tries to infer genetically defined ancestral population clusters. Here we're looking globally and think of each color basically representing an inferred ancestral population. Each line is a person and for each person you can infer ancestry from these different clusters. So here are the non-Africans, they tend to cluster based on geographic location. Here are Europeans and Middle Eastern individuals, East Asian, Oceania, Native American, Southern Indian, Pakistani. Now here I just want to point out all the color, just showing you a lot of genetic diversity in Africa, a lot of population substructure. Some of the briefly major trends in orange are the people who come from western Africa, they speak what's called Niger-Cortifanian languages. Here the Eastern Africans in purple are people who come from northeast Africa speaking Khushidic languages and red are people who speak Nile-Saharan languages like the Maasai, they came from southern Sudan. And then you have these outlier groups like the Hadza hunter-gatherers and here are the Central African Pygmies or Southern African Saan. Now these three, we then repeated this analysis just in Africa and these three populations represent those that have been studied by the HapMap International HapMap Project and the Thousand Genomes Project. And I can say that without these projects we would know almost nothing about African diversity. It's made a major contribution. But as you can see, it represents just a fraction of the variation present in Africa and even in small geographic regions we're seeing quite a bit of variation. That's due both to their demographic history but also likely due to adaptation to very diverse environments in Africa and as you can see quite a bit of phenotypic variation as well. So what we saw in the African-American dataset that we studied, not surprisingly, is that most of the ancestry is from West Africa. The next largest component we see is variation in European ancestry ranging from about zero to greater than 30 percent and then we see very small components of ancestry from other populations in Africa or from Native Americans and other groups. Now, this is not a surprise based on what we know about the history of the slave trade but I want to point out a majority, a huge proportion of individuals who are part of that African diaspora originated from this part of West Africa which is near Angola. Did I get that right? Angola. And we have very little knowledge about variation in that region. In fact, we still have very little knowledge about variation across Western Africa. So if we want to be able to apply methods to study diseases prevalent in the African-American community, we need to be looking in that region. And lastly, I want to talk about our studies to identify targets of selection in the human genome and these are important because it's thought that mutations associated with disease and modern populations, common diseases may have been selectively advantageous in the past. So for example, hypertension and diabetes, obesity and asthma. So here's just a set of some of the populations we've studied and they have very different diets like hunter-gatherers, pastoralists and agriculturalists. They have lived in very diverse climates and they have very different infectious disease exposures. So likely they've undergone local adaptation. So the first example I'm going to tell you about is our study of the evolution of lactose tolerance in East Africa. It's known that in people who can digest milk as adults, they have expression of the enzyme lactase fluorizine hydrolase or lactase expressed in the small intestine, it can break down the complex sugar lactose into glucose and galactose taken up in the blood. But in the most mammals in the majority of the world, this enzyme is shut down shortly after weaning. And then we're not able, people who have this enzyme shut down, if they drink milk as adults, they can't digest this. And it can cause severe intestinal distress. Now anthropologists have noted for many years a strong correlation between the prevalence of lactose tolerance and the prevalence on practice of daring or cattle domestication. So the highest prevalence is in Northern Europe and then it decreases in frequency as we go into Southern Europe and the Middle East. Very low frequency in East Asia, very low frequency in Native Americans, very low frequency in most West Africans and hence it's very common in African American population. But in East African groups that have cattle, they have a high prevalence of this trait. Now a mutation was identified in 2002 that is associated with lactose tolerance in Europeans but the African populations we're studying didn't have it. So we did what's called a lactose tolerance test where you basically give the sugar lactose, you add some water to it. You have, this is a time test so it can be kind of challenging in the field. Everybody has to line up, has to drink it at one time. This is actually a group of pastoralists from Ethiopia that we just recently studied.   And you're going to look at the maximum rise in glucose. And from that you can define whether someone is lactose tolerant or has the lactase-persistent trait in light blue or if they're intolerant here shown in dark blue, summer intermediate. So doing that and sequencing a candidate region, we were able to identify three novel mutations that are associated with the lactose tolerance trait in East Africans. And those are shown here. They were located at about 14,000 base pairs upstream of the lactase gene in a non-coding region of a neighboring gene. They arose independently from the mutation associated with lactose tolerance in Europe due to what's called convergent evolution. And interestingly, although these are very common, they are very geographically restricted in their pattern, their distribution in Africa. So that's demonstrating that you can have a functionally important variant common but very, very geographically restricted. And we would miss it entirely if we looked in West Africa, for example. And then when we looked at signatures of selection, we saw pretty whopping signature in that we looked at genetic markers going up 3 million nucleotides. And here in red are individuals who are homozygous for the C variant associated with lactose tolerance. And they're homozygous for millions of nucleotides flanking. So that's consistent with very recent strong selection, increasing this to high frequency and dragging with it the neighboring variation. And we can estimate the age to be about 3,000 to 7,000 years old. And that corresponds with the introduction of cattle domestication into sub-Saharan Africa. So a great example of gene culture co-evolution. But perhaps one could argue that Mendelian traits are the low-hanging fruit. So what we want to look at now are complex traits. And perhaps one of the classic complex traits is height. It's highly heritable, genome-wide association studies, and thousands of Europeans has identified hundreds of loci, each explaining a tiny percent of the variation in height. And I should point out that most are not part of the growth hormone IGF-1 pathway. Now in Africa, we see some of the broadest ranges in height, from short-statured pygmies in Central Africa to these tall and thin individuals in southern Sudan and in Kenya. And it's thought that this variation may be due to adaptation to different environments. Now I'm going to tell you about our studies of the genetic basis of short stature and pygmies. And whenever I do this to audiences who are used to doing genome-wide association studies in tens of thousands of individuals, I'm going to show you why that's not possible. So to get to the pygmies, we have to cross this river. There's a guy with a hand crank, basically, who's going to take us in the cars. And because I'm a woman, I get some shade, so that's good. And a few other hazards we run into, but I'm smiling because the head is cut off here. But actually, I want to recognize Dr. Alain Framont, who actually is from currently at the Musee de Lome, who's been working with the pygmies for over 30 years and did much of the sample collections. So the groups that we're focusing on, and I should mention that human geneticists have been interested in this for over 50 years and with not much success in finding genetic variants associated with this interesting phenotypic variable trait. So we studied three groups in Cameroon whose mean male height is 152 centimeters. And then we studied the neighboring Bantu-speaking people whose mean height is 170 centimeters. Now, short people of short stature commonly referred to as, quote, pygmies, unquote, exist in global populations, primarily in regions that are in tropical forests. And for that reason, it's thought to be an adaptive trait. Now, there's a number of theories about why that's so, but I'm going to focus on this last one. And that has to do with the remarkably short lifespan of pygmies. The chance of living to age 15 is only 40%. If they make it to age 15, the expected lifespan is about 25 years of age. So because of that, there is selection for early reproduction. And in fact, pygmies, at least this particular group, are reproducing earlier and they're reaching puberty significantly earlier than other Africans. So the thought is, and then the growth trajectory seems to stop at the point of puberty. So it's thought that you're sort of trading off growth for earlier reproduction and earlier puberty. Now, there have been just a handful of physiologic and metabolic studies done. Many of these were done by David Ramoyne who sadly passed away in the last year and Luca Cavalli-Sforza over the past 30 or so years. But there's just a handful of these. So I want to tell you first about a study in which we genotyped a million single nucleotide polymorphisms. And here's where you're going to be really impressed by my sample size. In 67 pygmies and 58 of the neighboring Bantu individuals. And here I'm showing a structure plot in orange of the Bantu individuals and in green of the pygmies. And you can see that they're highly admixt. And so in fact, the degree of admixture is directly significantly positively correlated with height. So the more Bantu ancestry the taller they are, consistent with this being a genetic trait. The other thing we did with collaborators at Cornell is we developed a method. This is actually really tricky with pygmies because there's no ancestral pygmy population. They're all admixt. And admixture has been undergoing admixture with the neighboring Bantu for probably thousands of years. So we developed a method to scan along the chromosome and determine tracks of Bantu ancestry in red and pygmy in blue. And the point is these tracks of Bantu are really, really tiny. So there's been a lot of admixture. And you can see this region of chromosome 3 where there's less recombination occurring at a position 45 MB. And the next question we wanted to know is how do the genomes of pygmy hunter gathers differ from the genomes of the Bantu agricultural list or of the mausipostralis, for example? And we did genome-wide scans of selection. And these are representing places where we saw evidence for selection. But there was a cluster right in that same region of chromosome 3, about a 15 million base per region. And we have no power to do a genome-wide association study. But under the hypothesis that this is adaptive, we focused on those regions that are targets of selection and then looked for association with height. And we found a number of significant associations. And this was one of the top hits within that region of chromosome 3 and encompassed several genes, one of which is DOC3, which had been associated with height in non-African populations. So we've replicated that. And nearby is a gene called SISH. It plays a critical role in regulating cytokine signaling. At the time we found this study came out showing that it's associated with resistance to bacteria infection, malaria, and TB in Africa. And interestingly, it directly inhibits human growth hormone receptor action by blocking the stat 5-phosphorylation pathway, mice that overexpress this gene are short. So that raised the question to us. Could selection for something like immune function directly result in short stature and pygmies? The last thing I want to tell you about is a recent paper we published in Cell in which we sequenced, we did high coverage whole genome sequencing using complete genomics technology in 15 diverse hunter-gatherers, including five pygmies and then five each from 200 gatherer groups in Tanzania. We identified over 13 million variants. And over 3 million of these had never been described, not in thousand genomes, not in DB SNP. So that represents a big fraction of diversity just from 15 people. Many of these are known regulatory sites. Now combining the studies, we wanted to say what pathways are enriched for genes near targets of selection in pygmies. These include genes that play a role in neuroendocrine signaling, reproduction, metabolism, and immune function. And we also see an enrichment for genes in pygmies that play a role in pituitary function. Indeed, one of our top hits is thyrotropin releasing hormone receptor. And that was interesting because it plays an important role in regulation of the hypothalamic pituitary thyroid axis. It influences a number of potentially adaptive traits. And anthropologists have noted for years that pygmies have a significantly lower level of goiter compared to the neighboring Bantu groups. And thus, it's been suggested that they may possess a biological adaptation to a low iodine environment. So here, again, we have something like adaptation to diet, which is influencing these traits, these other genes that have pyotropic effects. And lastly, the last question we asked for the pygmies is we look for SNPs, or variants shown in green, that were specific to the pygmies and at very high frequency. We're going to call these ancestry and formative markers. We found about 25 clusters across the genome. But the most striking cluster was right here exactly in that same region of chromosome 3 that we had previously identified. And what was striking is that included 44 pygmy-specific SNPs in 100% linkage disequilibrium, over 170,000 base pairs. It contained a very interesting candidate gene called Hessex1, which plays a critical role in development of the interior pituitary site of expression of growth hormone and other reproductive hormones. We found a non-synonymous variant associated with idiopathic short stature in the literature, but that was present in other Africans. What is unique to pygmies is that haplotype. So my hypothesis is that there's something about that haplotype that is altering gene expression in that region. Now, nearby, we found another cluster upstream of a gene called POU1F1, or PIT1 in mouse. Again, plays a role in anterior pituitary development and is a transcription factor playing a major role regulating growth hormone expression. So these are great candidates, and I also want to point out that these are the most differentiated regions of the entire genome in pygmies compared to other groups. We then genotype SNPs at these regions in a broader range of Western and Eastern pygmies, and we found a statistical association with short stature. And the next step is we're going to be collaborating with other investigators to make genetically modified mouse models so that we can see what the effect of these are in vivo. So they lead to some interesting hypotheses. One is that alterations in growth hormone, IGF1 pathway play a role in short stature in pygmies. Secondly, for the first time, we suggest that development and expression of hormones produced by the anterior pituitary play a central role in the pygmy phenotype influencing many traits like growth, reproduction, metabolism, and immunity. And third, that short stature could be a byproduct of selection acting on pleiotropic loci. Indeed, if you look at the function of growth hormone, which is expressed by the pituitary, it influences IGF1 expression in the liver and that influences bone growth, that influences height, but it's also influencing insulin metabolism and fat metabolism. And infectious disease is altering immune response and those cytokines are altering gene expression of many of the genes in this pathway. And here in blue are the phenotypes that we're going to actually study in the field. So my point is you have to take an integrative approach and to look at this as a complex adaptive trait. So lastly, I want to also say what I think is another future challenge is to use integrative evolutionary genomic approaches to study complex traits. We ultimately want to identify genetic, epigenetic, and environmental factors influencing complex traits and looking at this complex web of interaction. We can identify naturally occurring genetic variants that influence that web, and we can look at how environmental factors like diet and pathogens and climate influence this web of interactions. And lastly, if we compare individuals who have similar genetic ancestry, but they live in an urban versus a rural environment, we can see what some of the environmental factors are in urban environment and how they differ in terms of these physiological traits that might be leading to some of these common diseases in urban environments. And then lastly, we can have the opposite. We can have groups that have very different genetic ancestries, but living in a similar environment and have different phenotypes. So in this case, the Fulani and Cameron seem to have an innate resistance to malaria susceptibility relative to the neighboring group. And the Saan and Botswana seem to have an innate susceptibility to TB relative to the neighboring group. So I think this approach will be informative for identifying those risk factors. And I'll just end by concluding, Africans have the highest level of variation. The demographic history of Africans and local adaptation to diverse environments has resulted in population and regional specific genetic variation. And there's an urgent need to include ethnically diverse Africans in genomic studies to identify both unique rare and common variants which may be a functional significance including those associated with disease risk. And I will just thank the many, many people who contributed to the study and the funding agencies and most importantly, the many Africans who contributed. And if there's any time, I'm happy to answer any questions. It was time for a quick question. There's somebody at a microphone, we'll go with this. Hi, thanks for the terrific talk. I wonder if you could comment on the practice that is emerging or in the last few years seems to be gathering steam in the field that I work in which is sort of psychiatric genetics of consortium studies that depend in order to get their ends up on collecting samples from all over. I mean, so the one I'm thinking of in particular collect samples from all over the United States and Europe arguably a sort of a Caucasian European ancestry sample but very diverse geographically. And I just wonder in light of your work in Africa what you think about that. I think there's an urgent need to be studying psychiatric disorder in Africa and there's so little being done. I can't even tell you. I mean, there are major urban centers. I think it's possible to form collaborations and to start getting information on this but certainly in the more rural areas, no information. I mean, you just, you don't hear about it. It's not being cared for, not being, they're being cared for locally, usually in the village. So I think that's really important and we should be looking throughout Africa and forming consortiums. Can I answer the one other, okay. Yes, I was astonished by the very abbreviated lifespan of the pygmies and I was wondering if you have a list of the five primary causes of death within that population. Well, I think the primary cause of death is in very high infectious disease burden. So we know they have a very high parasite load, for example. Some of the other common causes, they just have a very harsh lifestyle living in this dense tropical forest. For example, one major source of nutrition is honey that's way up in the trees. There's a lot of falls from high areas, believe it or not.  I think I should stop here. I'm just trying to figure out whose phone it is. Let's bring it up. I think it's yours. Oh, it's not mine. All right, thank you very much. All right, thank you so much. That's terrific. Okay, our next speaker is David Kingsley from Stanford University. We'll talk about the molecular basis of evolutionary change, genomic insights from fish and humans.


I think we live in such a tragic, tragic, dark times right now. The verse that comes to my mind is, Isaiah, what it says, the horizon shine for your light has come. The glory of the Lord is risen upon you and behold, darkness has covered the earth. What happened with COVID-19 is darkness covered the earth. But before COVID left, deep darkness covered the people. We thought COVID was bad. What's happening right now is getting even worse. Almost everybody forgot about COVID-19. The restrictions for social distancing and masking all disappeared. Because now we have another problem that is risen. Why? Because darkness covered the earth. Deep darkness covers the people. My friend, the solution in this day and hour is the presence of Jesus. Because that's the only thing that can take the evil heart out of a man and change it into a kind heart. Like Pastor Ilya said and I want to emphasize is that you cannot legalize evil. We can put rules. If we think the rules work, they never worked for Israel. The day that Israel received the Ten Commandments is the day they broke them. And it's that day, 3,000 people, the Bible says they died, but the day the Holy Spirit came, 3,000 people got saved. And so the solution for us, we understand as Christians. Now for the world who don't have Christ, yes, we push for that, we push for that. We have to protest. We have to speak out. We have to speak for our brothers and sisters. We have to speak for those that nobody speaks, 100%. But at the end of the day, if God does not take the heart of stone and give us the heart of flesh, my friend, it's putting perfume on a casket. It's putting a dress code on a corpse. It doesn't make the corpse come alive. What makes a person come alive is the blood of Jesus Christ. It's the repentance from sin and faith in Jesus Christ. Can somebody give God some praise? And that's why I think like guys like Martin Luther King, who knew the gospel and who knew that the change is not in violence, the change. Right now what I'm seeing, I'm seeing hurt. And when hurt people, hurt people, hurt people. Only gospel helps to hurt people to channel their hurt in a healing process, in a healing way. For those of you who've been married and I understand that a lot of people say you need to speak up against the violence that is happening in the protest and destroying people's properties, hurting people because your hurt is wrong. There's no justification for that. And it takes away from the real issue that we are feeling and we are seeing in our nation today. It overshadows the real injustice and the racism, the violence and the looting and taking all of this stuff that is happening right now on the streets. Reminds me of the story of Absalom. He was so hurt by the fact that his dad never wanted to talk to him that he told Joel, he says that Joel never responded. And you know what Absalom did? He went and set Joel's house, Joel's field on fire. That was his way of getting hurt. But Absalom is not an example of godliness in the Bible. And I think for us, for every person here today who's married, you know sometimes when you're hurt in marriage, when you're not hurt in marriage, you do dumb stuff. So before we go blaming the protestors wrong people with violence who are taking this violently, we go against that. But we also have to have sympathy because we all know what it's like to hurt and say stuff and do stuff in our hurt that hurts other people. We all need God. Victim or perpetrator. Those who are hurt and those who are doing hurting, we all need Jesus. We all need God. Because somebody say amen. And we need God to heal our land. And we need to have the Holy Spirit give us new hearts and new mindset and new attitudes in this day and hour. And I like what Isaiah prophesied. He says arise and shine. Church it's our time to rise. We are the salt of this earth. We are the light of this earth. Right now there's more division that's happening on social media than has ever happened in any other place.  If you didn't speak out fast enough against this violence, you're guilty. If you spoke enough but didn't have tears, you're guilty. If you spoke too much, you don't like the other side. There's so much division that's going on and I believe that most of us need to get off of social media and get on our face before God and seek the face of God. Stop listening to CNN and Fox as God's inspired word. Pick up the Bible and find solution in Jesus. Come on somebody. I even one time some things seeing even different pastors, friends of mine. Terrified. I see sometimes the governor said he will do this. This governor said he will do this. There are threats and I see people trembling in front of the words of the government. My Bible makes me to understand that God will look on those who tremble before his word. And I wonder what would happen if we as Christians turn off the media for just a little bit and listen to God's word and shake and tremble before God's word and say God, I live for you. God, I will obey you.  I am not advocating rebellion and I'm not saying that we have to disrespect and dishonor but at the end of the day for God's sake we're Christians. We follow Christ. We're not first Americans and then Christians. We're Christians who happen to be Americans. We're not Republicans. We are Christians. And we have to arise and shine. Not arise and shine in a political vendetta but arise and shine in God. There is only one light and that light is not in a white house it's at a white throne. And Isaiah says in here that's not in my nose. I don't know where this is coming from but behold the darkness covered the earth and the deep darkness covers the people. You know when the darkness covered the whole earth it's horrible. But what's happening right now, it's heartbreaking. It's heart-wrenching. Seeing a man standing, a black man defending his store because the people coming in destroying his store completely people destroying, killing other more deaths are happening right now than happen by that unjust act of that police officer. Deep darkness is covering the people. But the Lord will rise over you. My friend it's time to shift our focus back from culture to Christ. You can't help the culture if you are indoctrinated by the culture. If you are influenced by the culture. If you are drunk with the same thing that they drink from. You can only influence something if you're not in it. You gotta be above it. And to do that we have to show love. We have to show peace. We have to show compassion. For do that we have to bring the real change and the Bible says and the Lord will rise over you. And then you can rise above that. And you can be not a divider by a uniter in your family, in your community and in our church. The Lord will rise over you and his glory will be seen upon you. Gentiles will come to your light. Not to your opinion. Not to your Facebook post. Not to your meme video that only brings division but to your light. And that light is nothing else but the fire of the Holy Ghost. When the fire of God is burning inside it produces light. My friend, world needs light. Need another opinion. They don't even need another video of somebody saying that hey I'm against this and against that. That's all they do. They need light. They need love and they need the Lord. The world will come to your light. The kings to the brightness of your rising.  They all gather together. They come to you. Your sons come from afar. That speaks of discipleship. They will call to make disciples. Not just make statements.  And you shall see and become radiant. And your heart will swell with joy. Not depression. Because the abundance of the sea will be turned to you and the wealth of the Gentiles will come to you. Come on somebody. I believe God is raising up a revival. God is wants to rise on us. He wants us to redirect our focus back to him. In this perilous, difficult and unsettling times. The country I come from there is a war that's going on between Russia and Ukraine. My wife is Russian. I'm Ukrainian. About four years ago Tri-City Harold did an article that says house divided. You know these two people that don't live together.  There is this division that is happening where I come from. My friend is happening everywhere where there are humans because if there are humans there is evil. And there is evil because of Adam and Eve and it's plaguing our nation and plaguing our country and we see that, we hate that and that's why we have to redirect our focus to Jesus. Redirect our desire toward Jesus and when he rises above us we no longer react, we respond. We no longer vomit our feelings. We speak as we spend time in the presence of God and we speak from the light. We don't just go in and just because a lot of what I see on Facebook is vomit. Vomit makes everyone sick.  Every husband here knows the issue that started the fight is no longer the issue after three hours. Now the whole issue is how we responded to the real issue. And the whole thing about that started everything is no longer a problem because six hours later when you're sleeping on the couch you're not sleeping on the couch because of that small issue, you're sleeping on the couch because of how you responded and how you reacted. And my friend what's happening right now in our country we need to come back to God so that the real issues can be addressed because God wants to not only fix the actions of the people who are causing injustice but God wants to also fix the reactions of people who are hurt by it as well. We're all in need of God. We're all in need of God. Just a commomo right now where you're seated let's just lift our hands and let's just ask God for our land. I know Pastor Ilya prayed for that but next 60 seconds open up your lips right now and I want you to say God change our hearts. No, no, no not just the police officers not just these people say to you say God change my heart because we're all pointing fingers at other people but right now we need to point a finger to ourselves since God transformed my heart is there any racism in my heart is there any prejudice in my heart am I having some kind of a thing against another race or another color or another tribe or another ethnic group God forgive me God wash me with your blood make me like Jesus Christ your son let your light come through me God the world doesn't need vomit they need light God give me more light in Jesus name come on 30 more seconds I want to hear every person praying every prayer I know you can speak I know you can verbalize your thoughts because I see what you do on your videos so verbalize your prayer right now verbalize your repentance right now verbalize your passion for God right now oh God help us in the name of Jesus pour out a spirit of grace pour out a spirit of supplication I pray God that you will give us a heart that is contrite a heart that is broken a heart that sees Jesus the heart that loves people the heart that is hurting the heart God doesn't just share an opinion but shares light Lord we pray that you will give us grace Lord we pray that you will give us mercy in our own families God where some of us push injustice where some of us abuse where some of us God are pushing hatred in our own family God and while we condemn others of their hate God we support our own hate God deliver us from that God set us free Lord from hate speech at home set us free God from all the uncleanness in our hearts God give us new hearts give us new spirits God transform us from the inside out Lord let us be a soul that didn't lose its flavor but a soul God that preserves our communities preserves our families God and makes a difference in our world in Jesus name we pray amen amen to God be the glory God is going to answer that prayer you know how because we are all part of the solution that solution doesn't start on the street it starts at home how you treat your spouse how you treat your kids how you react how you respond my friend it starts with me and it starts with you revolutions don't start at the courtroom they start in your room in my room and let all of this cause us to examine our hearts to live to God's standards not the standard of culture with that said today we are celebrating the day of Pentecost and about a hundred years ago William Seymour who went to Topeka Kansas City and heard about the baptism of the Holy Spirit he've seen people getting baptized in the Holy Spirit with the evidence of speaking in tongues but he didn't experience it himself he came to Azusa street in California and he started to preach the message of the baptism of the Holy Spirit that preacher in the United States people start getting baptized in the Holy Spirit God started to come mightily people were being healed in fact there were reports of fire trucks coming on the scene because people saw the fire on the top of the building and they thought that the fire was actually burning the house down but he didn't speak in tongues himself he started to intensify his prayer going from two hours a day to six hours a day to four hours at night him putting his head in a cold concrete and crying out to God give me more of your Holy Spirit and lo and behold God baptized him in the Holy Spirit I'm a Pentecostal the Pentecostal movement started from a black preacher presenting the message the full message of the Gospel and therefore as a church we have to be united while the world is separated the Holy Spirit unites us the Bible says on the day of Pentecost they were all together in one accord they were different people but they were in one accord and the Spirit of God came down the verse I want to read is Acts chapter 1 verse 8 and the verse says the following but you will receive power when the Holy Spirit has come upon you and you shall be witnesses to me in Jerusalem in all Judea in Samaria and even to the ends of the earth I want to highlight the word but why is Jesus saying but because after his resurrection disciples came and they got political what did they say? they say Jesus is this the time Israel will become the superpower on the earth are you the new king David Jesus because we got the army ready and Jesus says it's not your business when and how all of that stuff will happen the Father has it in his plan what Jesus was saying is political advancements violence taking over countries blood shed is not what he is king of he is the king of our heart and he doesn't win our heart dominance by sword or blood shed he doesn't win our heart over fear and over compulsion he says I win the heart through something different and he said but you will receive power and oh my friend it's not going to be white power it's not going to be black power it's not going to be green power it's going to be Holy Spirit power it changes the heart of man it changes the life of man it transforms the man from the inside out Alexander the great and so many great generals conquer the earth but only Jesus conquers the heart because you don't do it with the sword you don't do it with the force you do it with love and Jesus says I did not come to conquer like the rest of them he says I came to conquer from the inside out I came to take the evil evil heart out and put a new heart in and to put the Holy Ghost inside of that heart so that that heart can function and live for the glory of God but you will receive power it will be a different conquest it will be a different takeover it will be a different advancement than any other thing the world has ever seen because it will not be through hate it will not be through force it will be through a power that works by love the power of the Holy Spirit my friend do we want to see laws change you bet we do do we want to see our country have laws that protect the unborn yes you want to see the laws that honor God yes it will help our country but at least understand political changes don't change the heart when there was laws against homosexuality and against abortion it never removed the evil it suppresses the evil it never delivers us from evil the blood of bulls the blood of sheep covered the sin but only the blood of Jesus wipes them out what that tells me is as Christians we must take advantage of the power that has been given to us that is the solution for the problems we see in the world today that's what Jesus saw it one day Jesus will come and reign one day he will sit on the throne of David nations will bring him glory one day devil will be bound and thrown into the lake of fire one day antichrist and all of his lustuges are going to be defeated and destroyed one day a lion and the sheep will lie together one day there will be peace that exists in this world when the prince of peace will sit on the throne of David but until that day his conquest is not aimed at the white house it's aimed at your heart it's aimed at your soul and he said you will receive power when the Holy Spirit will come upon you as believers they receive the Holy Spirit in them the scripture says in John at the end after Jesus rose from the dead Jesus breathed on them and when he breathed on them he said receive the Holy Spirit they had the Holy Spirit with them in John chapter 16 Jesus says the Holy Spirit you know him because he is with you but he will be in you he was not in them yet he was with them watch this three and a half years of being with Jesus did not change disciples they still denied him forsook him and one guy betrayed him but the moment the Holy Spirit went from being with them to going in them Jesus was no longer there but something happened none of these men eleven disciples forsook Jesus none of them just maintained their salvation they flipped the world right side up they changed people for those of you who are like men I wish I would have been with Jesus physically my friend I have a bad news for you you would be unchanged you have the best resource available to you that changed disciples and it was not changed with Jesus physically it was having the Holy Spirit inwardly so Jesus says receive the Holy Spirit and at that moment after his resurrection disciples went from having the Holy Spirit with them to having the Holy Spirit in them see when Holy Spirit is with you he comes to be with you to convict you of sin when Holy Spirit comes to live in you he comes to convict you of righteousness see many people think the Holy Spirit is in a believer to convict him of sin but the Bible says he comes to convict the world of sin he comes to be with you so he convicts you of sin of not believing in Jesus not sin of smoking not sin of stealing those are the consequences of sin the real sin is the broken relationship between you and Jesus and when you believe in Jesus God gives you a new heart God gives you a new spirit you begin to change on the outside because you were changed on the inside any changed people we have in this house this morning my God and when the Holy Spirit comes in me he convicts me of righteousness why Holy Spirit? yes he reminds us of the wrong things he did but you don't need the Holy Spirit to be reminded of the wrong things you did when you have a new nature your new nature will do that for you what you do need the Holy Spirit is to remind you of who you are in Christ because people around you and your past and your consciousness will always remind you of your sin you don't need the Holy Ghost to remind you of your sin when you are saved you need the Holy Ghost to remind you you are righteous when you are saved because sometimes you don't feel righteous sometimes you feel dirty still sometimes you feel defeated still sometimes you feel alone still and the Holy Ghost comes to remind you you are righteous my God He comes in you to convict you of righteousness. He is with you to convict you of sin of not believing. But then Jesus says in here in Acts chapter 1 verse 8, He says, you will receive power when the Holy Spirit will come, what does it say? Upon you. Somebody say upon. Somebody say with. In. And somebody say upon. So when he is with me is to convict me of sin that I don't believe in Jesus. When he is in me is to convict me of righteousness. He comes in me, he brings his presence in me. But then when he comes upon me is to bring his power for the Bible says, so I can be, you will receive power when the Spirit will come upon you. So you shall be my witnesses, not gossipers, not divas, not easily offended, not whiners and complainers, but witnesses, not lawyers, but witnesses, not debaters, but witnesses. How many of you know you can be a witness if you haven't seen, heard, or experienced? You can only be a witness if you've seen something, heard something, or experienced something. That tells me that when the Holy Spirit comes, He releases power. This power will cause things to happen that I have a testimony of, that I can testify. I can witness of something. Why? Because I've seen things, because I've heard things, because I've experienced things. The Holy Spirit in me develops my character, but the Holy Spirit upon me releases me into ministry. My friends, Pentecost is not to make you Pentecostal. Pentecost is to make you powerful to fulfill your purpose, and our purpose is to win souls and make disciples. Pentecost is not so that we can have an addition to our prayer language. Pentecost is so that we can have a meaning in our Christian life of reaching the laws for Jesus Christ, of making disciples for Jesus Christ. Can somebody give God some praise right now? Hallelujah. There's something to wipe my face. You can't have more of the Holy Spirit. Thank you. When I got married, I got all of my wife. She did not come in parts. I didn't get half of her on the wedding, and the other half two years later. She did not come in sections. She didn't come in measures. She came all at once. But I am taking 10 years already to still figure her out. She's a deep mystery. I, you don't get, that's why you shouldn't pray, Lord, give me more of your spirit. You should pray, Lord, help me to know your spirit more.  He didn't give you a spirit. He didn't give you junior spirit. He didn't give you a trial spirit. He didn't give you, like, let's see how you do it with the spirit. He gave you the same power, the same spirit. But the issue is that you can't know Him more, and you can't know Him less. We all receive the same Holy Spirit at our salvation. Now, the challenge is to release this Holy Spirit. The problem is not receiving it. The challenge we have is how to release what we've received. Because you have the Holy Spirit the same way that there's water connected to your house, and the secret is not to call the city, say, add more pressure to the water in my house. The secret is to find a faucet that could release that water. Find a hose that can release that water and find a purpose for it. Because if you don't have a purpose for it, you'll flood the house.  You are not going to help people. You're going to use it to become famous. You're going to use it to become more important. You will use it for your advancement instead of advancement of the kingdom of God. The miracles and signs and wonders, they're not given so we can start ministries. They're given so we can win the lost. And so we can see the mission of Jesus continue on this earth. Somebody say amen. And so right now in the conclusion of this message, I would like to just touch on four things that we can do to release the Holy Spirit. I understand that I've taken already more time. So the first thing that I would like to mention is this. When you surrender to the Holy Spirit, you release the Holy Spirit. When you surrender to the Holy Spirit, you release the Holy Spirit. When Jesus died on the cross, He died for us. Galatians chapter 2 verse 20 it says, For no longer I've been crucified with Christ, no longer I live, but Christ lives in me. And the life that I now live, I live for Him who died for me. That tells me we as Christians believe that Jesus died in our place on the cross. Can somebody say amen? You don't have to die for your sin because Jesus already did that. Can somebody say amen? Those of you watching us on live stream comment below and say that you agree. If you agree with that. If you don't agree, we're going to get you saved right now. Because Galatians chapter 2 verse 20, Paul says that Jesus died in our place for our sin. If you don't accept Jesus's death my friend, you're going to have to pay for your own sins. But then when you get saved, Paul says this, Life that I live now, I live, I don't live for God. He lives out of me. He says that I no longer live. He lives through me. What I find challenging is, that's my personal challenge. I believe Jesus died for me. I do have a hard time behaving in the way that He lives through me. Because I, like many Christians, seek to live for God, which is the biggest hindrance to letting God live through you. I, like many Christians, instead of surrendering to the Spirit and letting the Holy Spirit live through me, I strive to please the Holy Spirit. The secret to Christian character is not to try to change it, is to stop trying at all and surrender. And surrender is the hardest thing to do because it gives you no credit for doing anything. That's why Christian character is called the fruit of the Spirit. It's not called the fruit of your discipline, New Year's resolutions, efforts and trying hard. My friend, if you want to release the Holy Spirit into your life and the power of the Holy Spirit, you have to learn, stop working on your character as much and start working on your relationship with the Holy Spirit. Start cultivating intimacy with the Holy Spirit because only the Holy Spirit can change certain behaviors inclinations and proclivities that are still lingering in your life. You cannot do that by trying harder. You can do that by trying different. And that different is surrendered to the Holy Spirit. I remember one time I made that announcement to my wife and I said, babe, I am no longer going to live for God. She looked at me and she's like, I said, from now on I'm going to let God live through me. She's like, okay, you get it. Good, good. But honestly, I started to practice that a mental shift, what I don't live for God. I couldn't earn my salvation. I cannot earn my sanctification. Holy Spirit has to live through me. And the moment I give the Holy Spirit, not a shotgun, but a driver's seat.  Give the Holy Spirit the driver's seat.  You know that at the first Pentecost in the Old Testament was 50 days after Israel came out of Egypt. And the 50 days after Israel came out of the Egypt, Moses received 10 commandments. That was the Pentecost. 3,000 people died. When God gave law to men, it brought death. Until Moses got the law, all the complaining Israel did, never once they got punished for it. The moment they got the law, the first time they complained, snakes came. The moment they built a cow, death came right away. 3,000 people died. But on the day of Pentecost, 50 days after Jesus' death, God didn't send the law and God didn't send Moses. He sent his spirit. 3,000 people lived because they were saved. I'm going to tell you, my friend, the solution is not to suppress your flesh. The solution is to surrender to the Holy Spirit. The solution is not to put more guardrails, more rules in your life. If rules were to work, 10 commandments would have made people holy. I'm not against rules. Rules have their place. But in Christian faith, we understand it's the relationship with the Holy Spirit that changes me, not the rules. Having more rules is not going to make me holy. Knowing the Holy Spirit more is going to make me holy. Surrender to the Holy Spirit. Can somebody say amen? The second way that we surrender to the Holy Spirit is by speaking in tongues. Surrendering to the Holy Spirit, the surrender to the Holy Spirit allows him to produce a character with us. The second way that I've released the Holy Spirit in my life is by speaking in tongues. Speaking in tongues is a great blessing from God. Isaiah chapter 11 verse, Isaiah chapter 28 verse 11 and verse 12, it says the following. It says that you will speak to these people with stammering lips and a no tongue. That's how you will speak to these people. And you will say, this is the rest for the weary. And this is refreshing. Yet you would not. In the Old Testament, God already started to give symbols of what will it look like when the person releases the Holy Spirit by speaking in tongues. They will experience refreshing and rest. In Jude it says when we pray in the Holy Spirit we build our faith. In Corinthians it says when we pray in the Holy Spirit we edify, meaning we build ourselves up. It's a spiritual workout. Speaking in tongues is a workout to your spirit. It's building of your spiritual muscles. In Corinthians it also says that when you speak in tongues you can bless God, thank God, and you can actually give thanks to God through speaking in tongues. By speaking in tongues you can also make intercession and pray for things you don't even know to pray for in says in Romans. So what I want to tell you something is that the way you release the great power of the Holy Spirit in your life is when you surrender. Stop striving. If you want to see a change in your character the Bible doesn't say don't fulfill the lust of the flesh and then you'll walk in the spirit. It says walk in the spirit and you will not fulfill the lust of the flesh. It's not about getting your character issues under control. It's getting your intimacy going so that it could influence your character flaws. The way you release the power of the Holy Spirit is not trying to control your life it's trying to yield to the Holy Spirit so he gives you self control. The second way is when you speak in tongues. Feel confused? Speak in tongues. Feel lost? Speak in tongues. Feel like not connected to God? Speak in tongues. Feel discouraged? Speak in tongues. Feel not sure what to do? Speak in tongues. This is refreshing and this is spiritual renewal by speaking in tongues. Speaking in tongues is a language of surrender. Speaking in tongues changes things in the spirit atmosphere and for those of you who are like remember husbands how many times your words got you in trouble?   What would happen?  God did not create creation out of chaos by moving his hands. He sat on his throne and he spoke the world into existence only when it came to you and I that he moved with his hands. Right now God wants to baptize people in the Holy Spirit.  There are people watching us on live stream there are people in this room who are here today and God prepared this day since the beginning of your Christian walk to baptize you in the Holy Spirit right now not toward the end but right now if you believe in the Lord Jesus Christ the Bible says God has already the Holy Spirit all you gotta do is you have to release the Spirit by speaking a language and God adds meaning to that in Jesus name in fact let's just do that right now while you're seated stretch your hands like this the whole church as many of you are Baptist in the Holy Spirit you're filled with the you're filled with the Holy Spirit for those of you watching us on live stream this is your moment maybe you've always wanted it you're like man this was this is not a strange thing Jesus talked about it apostles in the Holy Testament spoke in tongues so this is nothing strange this is not some Pentecostal craziness this is as normal as it gets to walk in the fullness of the Holy Spirit for those of you struggling to control your tongue this is your best remedy is to yield it surrender it to the Holy Spirit let's say this prayer out loud with me say Lord Jesus I thank you for the Holy Spirit Lord Jesus I receive your Holy Spirit oh Holy Spirit come right now fill me with the kingdom of God fill me with the presence of God fill me with the fire of God in Jesus name I surrender my body and my tongue to you right now I trust that every syllable you will add meaning to in Jesus name with eyes closed open up your lips with them just begin to pray in tongues whatever the syllables come on come on for next 60 seconds every person for those of you just trust the Holy Spirit the syllables that will come out don't filter them don't overthink them just release them just release them just as a child as a child remember it's a language of surrender it's not a language of educated it's not a language of the rich or the wealthy it's the language of a child to a father close your eyes just open up let the rivers of living water flow from your inner most right now God is filling people with the Holy Spirit all over this room all over the live stream right now as you are sitting in your living room open up your lips and just let the river come out it could be a one syllable just repeat it just let it go come on church 30 more seconds open up your lips let it flow some of you will sing in the spirit some of you will worship in the spirit right now some of you will intercede in the spirit right now Koto Ramassa Kera Ma La La Ma Kerebe De Rebe De Cantara Mania Oh Ramassa Srimanaka Ta Ra Ma La Ma La Ma La La Ma Darabahinda Darabahinda Kita Ramassa Turoboru Rebe De Rebe De Cantara Barabasataya Kou Ramassa Terebe De Rebe De Cantara Masoto Turobukete Rebe Kita Ramassa Tara Ba Kita Ramassa Tara come on church few more minutes Holy Spirit is moving all the river of God is flowing right now in this room spirit of refreshing that is the refreshing that is coming right now in this house that is the spiritual building that is coming right now upon you Lomo no Katara Ma Na Rebe De Rebo Koto Ramassa Tara Ma La La Ma Darabahinda Kete Rebe De Rebe De Cantara Barabahinda Darabahinda Darabahinda Tara Barabasataya Holy Spirit come Holy Spirit baptize your people right now Holy Spirit fill your people right now Jesus name Jesus name the way we release the Holy Spirit is by surrendering the way we release the way we release the Holy Spirit is by surrendering to the Holy Spirit to change us from the inside the way we release the Holy Spirit is by speaking in tongues for those of you who spoke in tongues for the first time I'm gonna ask you practice it pray it all the time pray all the time in the Holy Spirit number three is the way we release the Holy Spirit is when we share the good news the power of the Holy Spirit is released into the world when we open our mouth and we share the good news there's a lot of fake news right now everywhere there's a lot of bad news but when you share the good news the power of the Holy Spirit is released and lastly the way we release the Holy Spirit is when we have supernatural expectation to happen in our life meaning when we expect impossible to take place when we make room for miracles how do we do that by the way we pray by the things we expect and by the dreams we have it's interesting because these three don't require master's degree these three don't require for you to come and be born in a good family these three don't require a certain skin color a certain religious status and a certain thing that you need to have that the world says you need to have how you pray what you expect and what you dream of the challenge with many of us is if we don't surrender to the Holy Spirit he doesn't produce the character if we don't speak in tongues we don't receive the refreshing if we don't share the good news of Jesus and we don't make disciples we will not see the moving of God in our communities there's one big thing also many of us play too safe and we give the Holy Spirit no room to move the Bible says in Psalm again and again they tempted God listen to this and limited the Holy One of Israel meaning what Israel did is the things they asked for the things they expected and the things they dreamed of put a cap on God and God says I felt trapped I was incarcerated by your negativity you only saw your past you never saw anything else and God says you put me in a casket can you release the incarcerated prince the Holy Spirit pray bold prayers not small prayers that's why when the apostles got beaten for preaching the gospel they did not pray for safety they prayed for boldness because they said a great power is living in us we can't limit it by just saying God keep us safe we were called to change the world not to live comfortable and they said God stretch your hand to do miracle signs and wonders and the Bible says God came and shook that place God says I like that prayer I know the threat came from the government and the religious institutions but you didn't limit me by only asking for safety pray bold prayers don't just pray too God give me strength to recover or get through the cancer say God heal me from cancer don't just pray God keep my kids away from trouble in school say God let my kids possess the gates of their enemies we're not just praying God give us a bigger building we say God make us a movement that the devil cannot stop my friend don't limit the Holy One of Israel you might have no money but you have faith you might have no resources but you have an expectation when you wake up in the morning don't expect everything to go bad expect good things to come to you because you have the Holy One of Israel who says make me room give me room to move give me room in your faith give me faith but what if nothing happens see you're only thinking about your father and your mother then maybe nothing happened to you you're only thinking about your friends think about the Holy Spirit even if you only have to dream big pray big and expect big only to honor the Holy Spirit do it for his sake don't pray small prayers don't dream small dreams don't expect bad things why because the Holy One of Israel could be incarcerated limited the Bible says the living water wants to flow out like a river for some of us it's not a river it's a stream and there's some of us it drops and the rest of us nothing not because the water is not there it's my prayer the size of my prayer and I'm not talking about the length the size that means I can go and pray for two hours God, God, God, God I'm doing so bad and that's what Israel did in the wilderness it was horrible we missed the audience we missed the cucumbers of Egypt it was so good in Egypt God's like I don't get it you wind in Egypt you want it out and now oh God, it's so bad and instead of enlarging in their prayer making bold and saying God the giants are our food they are our grasshoppers we can't wait to conquer that land because the fear has fallen on the promised land we will eat milk and honey God, you crushed pharaoh you will crush every giant God, you are the holy one of Israel your cloud is with us your fire is with us, God what nation is there that has God as their God you are our God you are our king we don't even have a king but you are our king we're just bunch of slaves but without medical insurance without hospitals none of us are sick God, you're so good we don't have restaurants but you gave us men oh God, you're so good we can't wait to get the promised land that would have released the holy one of Israel that would have released the power of God God wants to be released God is tired of being trapped God is tired of being handicapped by small prayers safe prayers bad dreams and all this stuff it's time to rise and ask for big things that's right on Wednesday I was doing a conference on zoom with my friend Matt in Angelica Road she says I spoke in tongues tonight I was baptized in the Holy Spirit thank you Jesus Rosalind said I fell heat in my back like electricity and I'm healed of asthma Ernest said my back is healed I can fully touch the floor with my hands Stephanie said I had a horrible migraine for three days and now it's gone I can't stop crying Sergio said something just left my throat Cecilia said my ears popped Yana says I was healed of eczema praise God and Wednesday before the zoom meeting I said God I know this is weird having a conference on the zoom I don't know there's no music like there this atmosphere is different but God I'm believing for ridiculous healings God I know I'm in my flip flops in my office but I'm believing God through that you will do something I've never seen done because see I understand it doesn't take a lot for me to ask for big things but it could mean a lot to God here's his kid not just asking for something small knowing God is able what if you pray big prayers and nothing happens I'd rather die in faith than live in fear my friend I want to challenge you he who lives in you is greater than he who's in the world I want to challenge you what Elijah told to his servant he says there's more with us than those against us I want to challenge you that I can do all things through Christ who strengthens me it's time to reclaim your faith back it's time to reclaim your boldness and it's time to stop limiting the Holy One of Israel by small prayers expect good things expect miracles to happen this week for you expect doors to open for your business expect doctors report that will come in positive expect that when you lay hands on a sick they won't die they will live and declare the glory of God expect your child will come back home and they will not die out of drugs expect that things will turn around for your spouse in Jesus' name right now what I want us to do is we're going to pray because the day of Pentecost is the best day to pray for miracles and nothing impossible is possible with God now in Jesus' name if you're watching us on live stream if Ilya and Ivan come up right now if you're watching us and you have a sickness that you're fighting with right now let's agree together if you're in this room right now and you're battling with the disease you're battling with something that is maybe incurable I know you're fighting it this is not a moment to tap out this is a moment to take a step forward and fight with us as well you're already a fighter people sometimes message me they say I'm not sure God wants to be healed I say you're only not sure on Sunday because on Monday you're taking medicine like nobody's business because you're certain I want to beat this thing and then on Sunday you become theologically schizophrenic because you're not sure and I was like if you're so not sure throw away the medicine then I say but you won't do that because you know it's God's will for you to be healthy why don't you agree with us right now God is on your side He wants to help you we've seen a lot of people being healed we're not against medicine we're for medicine please take medicine go to the doctors get health insurance but there are certain demons that stand behind sicknesses that only the blood of Jesus can come eczema atasma arthritis tumors they have a name and they're gonna bow before the name of Jesus place your hand up on the part of your body where there is pain if you're watching us on live stream if you have eating disorders place your hand up on the part of the body where there is pain right now and let's pray together say this out loud with me say my body is the temple of the Holy Spirit my body is not for sickness and it's not for disease I think authority in the name of Jesus over every spirit of infirmity and I command it to go in Jesus name oh Holy Spirit I look to Jesus for the healing touch in my body in Jesus name come on Father right now we come against every person that has a problem with their stomach right now in Jesus mighty name we come against that problem in the mighty name of Jesus every breathing disorder be healed in the mighty name of Jesus we come against that darkness in the mighty name of Jesus skin conditions be restored in Jesus mighty name we come against that in the mighty name of Jesus every problem with cancer be healed in Jesus mighty name we release our faith over that body be healed in Jesus mighty name we come against every spiritual force that is afflicting that body in Jesus mighty name we push that darkness away in Jesus mighty name in the mighty name of Jesus Christ we come against every pain and joints we come against every arthritis in Jesus mighty name every arthritis and hips and any joints knees in the mighty name of Jesus Christ be healed in Jesus name be healed in the mighty name of Jesus Christ be healed in the mighty name of Jesus Christ somebody is watching who has arthritis in the right hand and it's painful for you to move right now begin to move it begin to receive your healing in Jesus mighty name in the mighty name of Jesus Christ we come against every arthritis use spirit of torment use spirit of infirmity right now we command you loose your grip over God's people in Jesus name be free in the mighty name of Jesus Christ in the mighty name of Jesus Christ every spasms right now we command you to loose your grip loose your grip in Jesus mighty name every muscle spasms right now I live in your body in the mighty name of Jesus Christ in the mighty name of Jesus Christ in Jesus mighty name we come against every growth in your body in the mighty name of Jesus Christ every precancerous growth every cancerous growth right now we come against you we destroy you we approach you in the name of Jesus Christ in Jesus name every lump we command you disappear in Jesus mighty name In the mighty name of Jesus Christ in Jesus name we curse every cancer we curse every lump We curse every growth we command you wither and tie in Jesus name Leave God's people alone in the mighty name of Jesus Christ receive your healing Receive your healing receive your healing in Jesus mighty name receive your healing in Jesus mighty name Let's pray with now for those people who are facing financial problems Let's right now lift every single person who is facing let's raise the hands the church There are people watching us right now who are facing huge financial problems Let's believe right now for supernatural financial supply as God did in the wilderness for the children of Israel Let's open up our lips for the next 60 seconds begin to right now declare a miracle money Let's begin to pray right now for a supernatural that consolation for open doors for jobs for people to be able to To be able to come out of that financial problem in the name of Jesus Christ father God We agree right now in Jesus mighty name of Jesus father you are Jehovah Jireh our provider father We lift our hands in faith father that you will provide father God however you're gonna do it Father we ask you guys that you would fill our barns and vats God give us ideas God father Supernaturally God depths being canceled father We stretch our hands to you God in the mighty name of Jesus father We ask for favor in the mighty name of Jesus open those doors father God for business deals contracts jobs Embedded jobs father God debts being canceled father God paid off in the mighty name of Jesus We stretch our hands Lord believing you God God just as you said to Peter cast that net on the other side father God We're casting our faith to you God Provide father God supernaturally Lord you are a supernatural God We stretch our faith to you God believing you Jehovah Jireh our provider in Jesus mighty name Right now I wanted to close your eyes and bow your head if you are watching us or if you're in this room and You don't know Jesus Christ as your personal Lord and Savior. I would like to give you an opportunity on this day When the Holy Spirit came upon church three thousand people God saved God is interested in your salvation God came through Jesus and died in your place for your sin the Bible says sins separates men from God Not only on this earth do we experience suffering and demonic torment but for eternity without the end There is no exploration eternity is very very long. It's very very hot and it doesn't have an end It's a place of hopeless suffering It's not a place where God created for the humans But for the devil and his demons but everyone who denies Jesus who lives in sin follows the devil That's exactly where they're going after with the devil. You don't want to go there If you have not given your life to Jesus Christ today is the best day Don't postpone it for tomorrow Don't comfort yourself with oh, I'm a good person if you would be a good enough God wouldn't send Jesus on the cross You are not good enough to go to heaven. You might be good enough not to go to jail You're not good enough not to go to heaven. Maybe you're saying well, I grew up Catholic my friend God You don't become a Christian by going to a Catholic church or Christian church You become a Christian by following Jesus and repenting of your sin If you would like to do that today and you say well, I would like to accept Jesus in my heart I would like to accept him as my Lord and my savior If you are in this building, I want you to just raise your head. Thank you. See your hand brother. Thank you If you're watching us on live stream, you can just comment below and say hey, I would like to pray that prayer Let's pray the prayer together with me right now. I want you to say Lord Jesus. I am a sinner please forgive me of all my sin and wash me With your precious blood. I surrender my whole life to you right now Come and live in me Be my Lord and be my savior in Jesus name Amen for those of you who pray the prayer and you are in this room We would love to see you in a VIP room and Ricardo. Could you wave your hand at me? That's where VIP room is gonna be in that room if you're a first-time guest Your first time in our church whether in town or out of town We would love to see you there want to give you a gift and meet you and if you pray that prayer If you're watching us on live stream go to hungry gen that comes last VIP if you pray that prayer Let us know so we can reach out to you and pray for you church before we exit right now We would like to let you know that we will have only about three minutes To be in this facility before we need to sanitize it and prepare it for the next service We're gonna take our offering time right now We have three ways to give one of them is the traditional the envelope in front of your pew The other way is through our church center app You can download church center app and then you can set up your giving there or you can go to hungry gen comm slash give It's you're giving the helps us to support On Friday one of the things that we did this week is we gathered if we can just take a moment and pause before going anywhere Just for a second on Friday one of the things that we did with our team after prayer is we we bought really nice Products and food and groceries and brought to the elderly in our park because we're trying to also establish a better relationship with the elderly people Those are the people that right now are going through a very difficult time because they're more exposed to this virus And so you're giving helps us to do a lot of good in our community It also helps to spread the word of God to all the parts of the world if you're watching us on live Be a part of this as well. You know, this is not a moment to just turn it off This is the moment to join in hungry gen comm slash give let's pray for our giving right now And you can drop your offering on your way out today, Lord I thank you for the opportunity that we have to give into your kingdom I thank you for the opportunity that we have today God to work and To do good in our community through our finances I pray God as we bring our tithes as we bring our offerings today I pray for every family I pray for every father every mother every college student Every retired man and any retired woman that you're gonna supply their needs according to your riches and your glory God and Let father our church advance the kingdom of Jesus Let our church advance the message and the agenda of heaven in our community and to all the world Let more people be saved healed and delivered through this ministry because we give because we love Lord Bless every giver today God in the name of Jesus in this hard time help us to not only survive But thrive financially in Jesus name Amen


If you need men 21 coins for anything, make sure to go to buymuntcoins.com. Check it out with the link in the description and my code MMG is 15% off. Ah! Ah! Ah! Oh my God! Hello. This is good morning, MMG. Game start at 10 AM Pacific, not a fan. I miss my 1PM Eastern games, which means Jamo is still sleeping actually. So I'm gonna make him a coffee and wake him up like a good roommate. Just kidding, I don't have sex with him. No coffee for you. You are already wired.  I bring you coffee. You bring me coffee? I do. What do you want? What do you want? Ah! No. Luna Barkiff's lines are gonna win today. Gets the Falcons. Eh, he-he. I thought she wasn't gonna either. Luna, Barkiff Mapetricius is the worst coach ever and it's gonna get fired this year.   For my breakfast, I'm going coffee and I'm not sure yet. Here's what we're doing. Lightly toast the bread. Two eggs, ham, turkey. What she makes? This is bread. Can barely handle this. Wow. Super heat. Look at that, bro. Look at that. Maybe I shouldn't be a woman.  Very nice. Lions take a 7-0 lead. Good start. I think it's about time to bench bake her Mayfield just through a massive interception and Odell got hurt on it. By the way, I'm taking my fantasy team and throwing it in the trash can. I'm so bad, I don't wanna talk about it. I'm gonna show you guys my fantasy team. It's actually one of the saddest things you'll ever see. It's 12 Man League. This was my second year.  Aaron Jones out. Miles Sanders out. Odell just got hurt. If you wanna know how bad it is, my starting running bags right now are Latavius Murray and Frank Gore. Those are my two starting bags. In my other league, I have Aaron Jones still in. Didn't know he was out today. And Justin Jackson. The person who was carrying this team was Dak Prescott. Dak Prescott is now out, which is so depressing. There's Dak, so sad. This was really late, Jeffy, but maybe that'll be worth it. Miles Sanders is out.  He wins been amazing. That was my best pick in this league. Alan Lazard. Oh, I love him so much. Man is out right now. Here's my starters. So Odell just got hurt. Falkham actually stood. Godwin we're hoping, but dude they just got Antonio Brown so he's gonna lose targets. And then this dude, that's just so embarrassing. But as of right now, my team's not. Not playing bad. I got a 40% chance to win right now.  And then in this league, I didn't know Aaron Jones was out. Pretty much Rodgers and Aaron Jones carry my team. Justin Jackson, Tyree, Cole Beasley in both leagues. Jared Cook, Marvin Jones. I have Zach Moss and Camakers. I need one of these two to pan out or I'm just so screwed. The Monday Parker's really good, but he's questionable right now. Was horrible at the whole drafting two running backs thing. I was like, that's dumb. And then made the same mistake again. So you know what? Next year, that's my year. That's what we're going for. I'm gonna say that every year for a couple of years now. Operator. Let's go operator. 50 bomb right down the schmiddle. Easy money. I missed that Crestcott. Imagine losing to a team that doesn't have a mascot. Couldn't be me Dallas Cowboys. This man is convinced that the Andre Swift is the next Alvin Camero. He tells me in every day. Throw it up.  That's Alvin Camero right there. Next Alvin Camero. Next Camero. Camero. 10 to 14, I predicted on Twitter would be 31 to 21 Lyon. And we're technically on good pace for that. Cause we have our one field goal already. Lots going on right now. Prater drilled a field goal after missing earlier 16-14 Lyons. My score prediction may be wrong, but I think we'll get the dog. And Steelers are marching down right now 27-24. Looking like they're gonna score and run this clock out. I'm interested in this game, dude. Baker, I was saying Baker needs to get benched earlier. Baker's playing amazing, but also playing amazing. Imagine losing a team who's starting Corbin Skyland. I'm actually about to beat this dude with Aaron Jones out and Justin Jackson is my starting running back. It can happen, dude. And Dalton just threw a pick. It's over if they get this.  Oh my God. That's over, bro. We just lost the Falcons.  Why would you throw that? You throw the check down and you kick a field goal. He just threw the triple coverage. Look at that check down right there. You throw that check down right in the middle of the field. Triple coverage versus a drag underneath. Come on, man. Wait, did you score? She win. Dude, what was that? Oh my God. Oh my God. All right, they got the two point. Lions got scored in a minute four. Stafford's built for this. If since he scores here, it's identical to the Lions game. Fourth and inches. What do we got here? Play action. That's a touchdown. Baker Mayfield's got a yep, minute six to go score, same as the Lions, pretty much. Dude, are the Titans gonna go into OT again? Spike it! Spike the gut! What's the flag? Show me the flag! It might be on Sportsman Live for delaying the spike. Is that a catch? Yup, that's a catch. That's 100% a catch. Yes, yes. Lions pull the shoot off 12 and four season.  And I think the Steelers are about to be undefeated. One time out left. Third down. Don't you dare DPI that. Dude, look at this catch. Do the 10 second rundown. Shit to lose the game again.   Oh my God, it's about to be OT. He shanked it! Dude, I've got to see Shank in that. Look at this bet I have. So it was Steelers to win and the over. So it hit the over by a point and the Steelers won off the shank. Easy dub. Oh, oh, so season three. Oh my God, we could do it. Win probability full. You're giving me a 4% chance to catch this ball?  That's, this shit's over. Let's call baby. Come on, baby. Come on, baby. 4%? 4% my dakin' in balls. Let's go. Girlie, sunk the game.  Oh my God. Whoa, whoa, whoa. What's the flag? Whoa, whoa, whoa, whoa, whoa, whoa, whoa. He's got to kick a bomb now. DPGA. People's Jones. That's his second catch, right?  Yeah, dude. What's that from? That's from the 30 SF-48 airfield. Come on. Come on, buddy. Oh, penalty. Offsides. Got him anyway. Offsides, decline it. That's got to be offsides. I saw a flag come out. What was that? Offsides.  Let's go. Oh my God, I'm so happy. This is the week I started filming this Sunday thing.  Stafford, goaded. Hawkinson, goaded. Falcons, bad. Girlie, bad. Matt Ryan, bad. Disgrace to my name. All right, gonna end this video off now. Just got done watching the Seahawks Cardinals game. Oh my God. I hope you guys got to see this. The best football game I've seen in a long time. Well, cool. Sorry I didn't get my reaction for the full game. I know next Sunday, and as you keep going, I'll try and make this series as best I can. I appreciate you guys so much. I hope you enjoyed. Let me know, and I'll see you in the next video. Peace.