Thanks, Teri. And I'd like to also thank all of you for taking time out of your schedules to come to this meeting of Genome Medicine 9, and just a reminder that all of the materials from the meeting are actually available on a website at the NHGRI website, so the materials and the presentations are accessible from there even after the meeting is over. And I just wanted to start with a little bit of introduction to the meeting itself. So all of us have seen this graphic many times over the past couple of years, representing the valley of death as it's called between basic science and clinical applications of basic science. And I think in the past couple of years, especially in Genome Medicine, there are some cases of successful traversal of this bridge. In cancer, for example, the emergence of targeted therapies based on genomic evidence, the development of tools and technologies to enable translation of genome information into diagnostics, into clinical practice. There are a few wonderful use cases to illustrate that this bridge can, in fact, be traversed successfully. But it's not necessarily a straight shot. So there's a lot of handoff points going from basic science into clinical relevance. And some of these in Genome Medicine at least appear to be lost in translation. There's needs to be translation of discovery from model systems to the relevance to human and back again. There's then the need to translate some of these findings from basic science to specific populations of patients. And then the translation of the information and knowledge into actual clinical practice. And at each of these handoff points, there are specific challenges and needs. And the communities are often not in perfect alignment to make that possible. So for this meeting, for Genomic Medicine, number nine, we're going to focus on one of the particular challenges along this path from basic science to clinical relevance. And that is understanding these variants of uncertain significance. So genome technologies have really revolutionized approach. We've been generating, as a community, very large data sets of DNA sequence from patient populations, but only a small handful of the variants that are discovered as a result of these large-scale genomic initiatives actually have enough knowledge, enough evidence that they can be translated into something that does have relevance to human health. So the objectives of this meeting are really to discuss the gaps, the technologies, and also some use cases of how these handoffs and this bridge from basic science to clinical relevance have been successfully traversed. What can we learn from those use cases? How can we, what do we need to do to better align basic research with clinical medicine in the area of genomics? Those are the kinds of things that we're wanting to come out of this meeting today. And so for the topics that we're going to discuss, it's going to be quite wide-ranging. There are going to be, as I said, sort of some talks this morning to set the stage from the basic science perspective and from the clinical perspective about where those gaps are. There's going to be some presentations about the successful bridging between basic science and bench and back again. And then we're going to talk about some of the technologies and tools that are being developed and need to be developed further to help facilitate these lines of communication and alignment of research. One of the things that we're not going to talk about though, just we're not going to touch much at this meeting on kind of the regulatory hurdles and the payer issues. Those are very important and large gaps and transition points along this trajectory. But we felt it was important to focus our discussions. And those were things that, if we had a week, maybe, but we have two days or a day and a half. So when we were planning this meeting with the members of the Genomic Medicine Working Group, we had, as our informal tag, bench-to-bedside, mind-to-gaps. But as Teri has shown you, from the past genomic medicine meetings, oftentimes what spins out of these are initiatives that are really powerful and productive in addressing the issues. So we're hoping that when we look back at this in another year that instead of mind-to-gaps, it'll be amend-to-gaps that will come out with some ideas and that might spin off into initiatives that will actually help us address some of these transition points that are vexing us and translating. So before I hand it over to Dan Rodin to moderate the first session, or actually hand it off to Eric in case he has a few comments to say, I do want to acknowledge the efforts of a number of people who brought this together, specifically Rita, Rita Chambers in the back here with her broken elbow, Teji, Ellie. Members of the Genomic Medicine Working Group who are really instrumental in putting together the agenda that we have today, our technology team for setting up the webcasting and the audio portion of the meeting. Without these guys, this meeting wouldn't have happened, so I really want to congratulate them and thank them for their efforts for this meeting. So with that, I'm looking forward to a very productive couple of days. Thank you again all for coming, and Eric, I turned it over to you.


Hi, in our work, we present a multi-Q wearable haptic device for the control of the center of pressure for post-recorrection. The deselected cues, differentiated also the receptor's level, are the vibration for the control along the sagittal plane and the squeezing for the control along the frontal plane. Our validation experiment was performed comparing the proposed haptic guidance with visual guidance. Results show no statistical difference between the two guidance conditions in terms of such a straight nor execution time. The subject evaluation convinced this trend. Thank you very much.


Yes, Roma Wines taste better because only Roma selects from the world's greatest wine reserves for your pleasure. And now, Roma Wines, R-O-M-A. Roma Wines, present. Suspense! Tonight, Roma Wines bring you Roddy McDowell in One Way Street, a suspense play produced, edited and directed for Roma Wines by William Spear. Suspense! Radio's outstanding theatre of thrills is presented for your enjoyment by Roma Wines. That's R-O-M-A. Roma Wines. Those better tasting California wines enjoyed by more Americans than any other wine. For friendly entertaining, for delightful dining. Yes, right now, a glass full would be very pleasant as Roma Wines bring you Roddy McDowell in A Remarkable Tale of... Suspense! Back home again. Back home on the street. Courtney Lane is what the sign on the lamppost says, but it's just the street to those that knows it here about. A few that doesn't. What with the name it's got. As dirty, rotten, Roma spot as you'll find in the old of London. Oh gee, Georgie! William's back home again, are you? My time, isn't it? Quite a proper man you've grown to be too. We've missed you, Georgie. More than I can say for you. The street. The only home I've had since my mum and dad was taken. The Blitz, that's how they got it. And now I came to live with my Uncle Bert, if you can call that living. Where I've been the last six months as due to him. Dartmoor Penn. One of his little schemes that he taught me into saying how safe it was. And it was for Uncle Bert, but not for me.   Only he'd never get caught. They could prove it on the dead one sooner than they could on Uncle Bert. Come on, come on, move along there. Hey, you there, just a minute. You're George Williams, ain't you? That's right, Copper. What of it? Oh, nothing at all, me lad. Just mind you don't cut any fancy capers now that you're back. I can take care of myself, I can. And if you can't, there are those that can, you know. That's what it's like being from the street. You're marked with it. If you're kin to Uncle Bert, it goes for double. But there's no place to go. So, uh, I'm going home. Georgie! Georgie, lad! Hello, Uncle Bert.  Come on in, come in. Welcome home. Oh, I'm coming in. There's no need to carry on so about it. Kelly, on the very, for you're the prodigal son you are, Georgie, me lad. It's the fetid car for you. Come off it, Uncle Bert. You don't want me back. If there was any other place in the old of England for me to hang my hat, I wouldn't be back. Oh, my boy, now that hurts, that does. I think you'd say that to me what raised you from a young lad. And got me a six-month stretch of hard labour to top it off. Downright ungrateful I am, eh, Uncle Bert? Georgie, yeah, I don't know. You'd go ahead and do something I only spoke about in jest. Yes, but if I'd come home with a swag, you'd have had your share quick enough and know just about that. Well, I'm sorry for what happened, Georgie. You never know what I've been through, blaming me so for it so well. Goodbye, Gonsie. Bye, Gonsie. But come on into the bed. I've got a bit of a surprise for you. Hello, George. Mrs. Pendry. Oh, you see, Bert, he does remember me. Isn't that nice? I couldn't very well help it. Seeing all the errands I used to run to you from the shop in I Street, I hardly expected to see you down in these parts, though. Well, you see, I don't have the shop anymore. Oh, so did I. Yes, and... Oh, Bert, you tell him. Tell me what? That's a surprise I was telling you about, Georgie Led. Mrs. Pendry and I got itched last week. We're married. So, you see, George, you'll have to call me Aunt Edna now. Married? First, wet me off my feet, he did. You married him? And why not? George, I know it seems a bit queer to someone your age, two people as old as we are. But we were both lonely. Since my husband died, I've had no one... Hey, she needs someone to take care of her. Can't get it that much now, you know. My old heart.  Oh, she let me take over the job and made me the happiest man in the world to boot. You do understand, don't you, George? Well, I... I expect you'll be moving out of this rat hole, then. Both of you will go and live in your house. I expect, eh, Mrs. Pendry? Mrs. Williams now, Led. Aunt Edna. Aunt Edna, then. Well, you see, I don't have my house anymore, George. Ah, there's a cabbie lot around here. Well, we didn't want to give him any chance to say I'd marry Aunt Edna for her money. So I sold my house, too. But I don't care where I live, so long as I'm with Bert. And you're just as welcome here as ever.  What's up? Where is it? Where's what? You know what? The picture.  Oh, Bert. I asked you to leave it where it was. There's a new mistress in the house now, Led. Never mind about that. Where's the picture? Hand it over. Well, mind are you too. Hand it over, I said. And it's no good raising her out because I can't hand it over. What have you done with it? You had no right to put your filthy hands on it. You must know I've burned it. Burned it? The only thing I had in the world to remind me of her. Why, why, you want no... Well, you keep away from me now. Don't you raise your hand to me. Bert!  Now, now, now, see what you've done. Whoa. What's up with her? Let her in yet it here. Give me a hand. Get her to her room. No, I... I don't need you both, but... if George wouldn't mind... getting me a piece of my medicine. Get your blue bottle in the kitchen cupboard. A teaspoon and a half like glass of water. Go on, don't sting there. All right, all right. Keep your air on. Come along, my dear. Now, now, come on. On the bed with your nap. There, there you are. Here's your medicine. Here, give it to you. Here, here. Here, drink this nap. Oh. Thank you, Bert. Feeling better now? I'll be all right after a bit. I'll just lie here and rest for a while. If you don't mind. All right, you are. We'll be just outside here if you want anything. Come on, Georgie.  There's nothing to thank me for. It's a bed of a verse. Ask me fair what it to death. I dare say. What's the game, Uncle Bert? Game? What game? You know what? This marriage business. You heard what she said. We was both lonely. Lone.  Not you. George, you're speaking of my wife. Your what? Your wife's money. That's all you've got your eye on. Ah, so that's it. Then why didn't I move into the fine posh house of theirs up in our street? Why didn't I? Because you'd rather have the cash, I expect. All right. Suppose I do come into a bit of test one day. One day? If you can wait that long. And just what do you mean by that? I don't know. All I know is I'm not having any. I'm clearing out now, tonight. But I didn't go. Oh, I don't know why. That night when it was late enough so I reckoned they'd be asleep, I made straight for the kitchen. I was near dead from hunger I was. I started rummaging through the cupboard. Then I saw it. Right next to a bottle of medicine. A little box it was. Marked with a skull and crossbones. Poison. Rat poison. Hello, George. Ed. Why, what's the matter? Look as though I'd scared you half to death. Oh, me? Oh, no, no. You just came on me a bit sudden. That's all. I didn't expect to find you up. I've been wanting to talk to you. Why?  Well, if you must know, Uncle Burt and I don't quite see eye to eye on one or two things. But, oh, well, I'll be out of his way soon enough. Never fear about that. George, I know Burt isn't all that. Well, I know what people say about him. But he's been good to me. Got his reasons too, I daresay. He's a sharp one, he is. He's been good to me, and perhaps if he had a chance, if he hadn't been in the street, he'd have been a good man all his life. The street. That's what we all put our troubles onto here. The street. I know it's hard, George. But if maybe you could get yourself a bit of education. Oh, why, of course. All I have to do is trot along up to ox with the rest of the millionaire's sons. No, I didn't mean that. Just learn a trade for his daughter. And for the money? Well, I've got a bit of money. Oh, no, I don't need any help. Yours or anybody else's. While the last six months I've had about all the reforming I can stand. It's not that, George. You're like a nephew to me now. You'd better stick to reforming Uncle Burt. He needed as much as I do. He needed a bit more. Oh, hello, George. I told you you'd get hungry if you didn't eat. Proper fortune teller, you are. What are you doing up at this time of night, Edna? You shouldn't be jumping up in the middle of the night with your heart and the shape it is. Oh, I heard, George. I just wanted to see if he was all right. Well, up along the bed now. There's a good girl. I'll take care of it, Georgie. Well, good night. Good night, my dear. You're not in a proper mood, George. You'll never make your way in the world. Not the way you're going about it. I suppose you know just how to go about it.  I wouldn't say that. But I know one way. And I've got me plans. What's this? This part of your flans, is it? That? What? It's rat poison, ain't it? I ain't never seen no rats around here. Well, there's no arm having a bit of Andy, is there? Hands of prevention is worth a pound of cure, you know. And a proper Andy place you've got for it, too, haven't you? Right next to a bottle of medicine. Ah, so that's it. So now I'm a cruel and inhuman monster that will poison his own wife, is that it? I didn't say you would. But I... I didn't say you wouldn't, neither. I think I got it all planned, eh? I slipper the poison and no one even bothers to ask why she growled up because they all know she got a bad ticket. Is that the way you see it? I see you've done a bit of thinking at any rate. Now look here, George, me lead. Even if I was the monster you say, I'd be the last one to kill her. Don't you see? Not yet I don't. I have to make out her will, Georgie. I'll get the stuff anyway. I can afford to wait. I don't know about certain other parties, Georgie, that would benefit along with me. But I can afford to wait. For Suspense, Roma Wines are bringing you Roddy McDowell in One Way Street. Roma Wines' presentation tonight in Radio's Outstanding Theatre of Thrills. Suspense. Between the acts of suspense, this is Kendall's for Roma Wines. The time-honored custom of making a good dinner better with wine is especially appreciated when the wine is distinguished grand estate. Let grand estate wine make your meal times more pleasurable. The simplest dinner becomes an adventure in gracious dining when enriched with a friendly glow of candle life and the ruby redness of grand estate California burgundy or the pale, glinting gold of grand estate sautern. And how much more flavorful your dinner will taste served with a grand estate wine. For each grand estate wine is a distinguished limited bottling by Roma, America's greatest vendor. Each grand estate wine is born of choicest grapes, then patiently, unhurriedly guided to mellow rich perfection of taste by age-old skill, necessary time, and the unmatched resources of Roma master vintners. Tomorrow give the magic touch of distinction to your dinner with a grand estate wine by Roma, the crowning achievement of vintner skill. And now Roma Wines bring back to our Hollywood soundstage Roddy McDowell as Georgie Williams, with Raymond Lawrence as his Uncle Burt and Jeanette Nolan as his Aunt Edna in One Way Street, a tale well calculated to keep you in suspense. I should have known it then that today I found the rat poison what Uncle Burt was up to. I knew he'd married Edna for a money. I knew he was rotten enough to lie, I watched him like an orc. I fixed all the meals myself, seeing I wanted to help around the house. The poison was always there, up in the kitchen cupboard next to a medicine with the skull and crossbones on it, on the scene. Oh, hello there Georgie lad, just in time to have a spot of tea with us. Tea? Well, what's more about that? We're not tofts, prebs, but we can have a spot of tea all the same, I expect. It was Burt's idea, said it made us seem more of a family like. Have a cup Georgie. No thanks, but I'll, I'll turn the tray around for you though. Here, here, hold on. Looks a bit unsteady, but oh, there you are. Now, you get Aunt Edna's cup and she gets yours, but there's no matter is it? Of course not, it's all the same tea. You don't mind, do you Uncle Burt? Why, no, no, why should I? Oh, it is nice to have a cup of tea about this time of day. I'd almost forgotten. Well, drink up Uncle Burt, we'll only get cold sitting there. What's up, Pettishie nutty? I like it a bit cool and myself. Well, is there anything wrong with your tea, Burt? Mine's lovely. Shouldn't be anything wrong with it. Fix it himself, he did. Of course there's nothing wrong with it. Oh, no, love us, Burt. No need to take it all down in a gulp. Think you were swallowing rank poisons. Something's sticking your throat then, Uncle Burt. What is it? There, there. Oh, I've got to swallow in me wind pot. It's good now. Fix me another cup like a good lad, will you, Georgie? You can sit mine too, if you will, Georgie. Right, you are. Do you know where the tea is, Georgie? No, I... No, it's in the kitchen cupboard there. Right next to the medicine. You'll find it, Georgie. Right next to the medicine. But the tea wasn't next to the medicine. It wasn't there at all. Only the little box was there, the skull and crossbones, and still unopened. Poison. I found the tea and poured out the two cups. But all the time, my eye was on the little box. I was thinking how I had to get away, had to get away. And about the money, and how easy it would be. And then it come to me, all in a flash, what Burt was up to, and why I'd done nothing about it. Because he'd known what I was thinking before I knew it myself. He knew what I was thinking out there in the kitchen right then. He knew what I was thinking about... Murder. That night I hid the box. Didn't chuck it out, mind. You only hid it. In a place not too hard to find. Next morning it was back in the cupboard. Right next to the medicine. Poison. No mistake about it now. Another of Uncle Burt's nice, safe little schemes. Safe for him. You'll become right out in so many words with it. Nothing to arrange but the terms. I knew he'd get to that too, once he was sure of me. All he had to do was wait was what he thought. Wait for me to kill her. Cleaning up the breakfast dishes, eh?  Georgie, I was looking for that rat poison last night. And the devil's own job to find it. I could have told you where it was. Found some rats at last, have you? Not in particular. I thought it best to have it out there where it's handy though. Well it's handy now all right. So where I put it, did ya? I look here Georgie. You know how I feel about you. What's mine is yours. Whatever I have, or whatever I might get. Share and share alike. 50-50. Partners, that's been. First I've ever known you to offer a bloke so much as a time of day. I might be the last too. But the one time might be worth all the rest.  That says maybe. But if you're partners, you're taking your chances together, aren't ya? Both of you in the same, for bad of a good. Got to treat each other fair and square then, don't ya? If it's like that. That's how it is all right. You think it over. See if it ain't. Sir. Yes my dear? Could you bring me a bit of my medicine? Not taken bad are ya? Not fair, but a bit of the medicine might help. Right you are. Well Georgie, you know how to fix it, don't ya? I know how to fix it. I'll just nip along down the road then. Got a few things to attend to. But I'll be back in plenty of time. Minds you are then. And Georgie, fix it right this time. I got the medicine and mixed it up as usual. I scarcely knew what I was doing. Because all the time I was thinking about the street. About my shirt that was always frayed and dirty. About my baggy second hand soup. And now, well what did she matter to me anyhow? She was a sure thing to roll up in a year or two anyway. What with that ticker of hers? And if she did now I was free. Free. Next thing I knew I'd open the box and dunk enough of this stuff into her glass to kill a cart horse. Then I was carrying it into her. Walking like in a dream. And wondering where my voice was coming from. It sounded so strange and far away. Just sit it down on the table will you Georgie? Right oh. What you aren't Edna?  You've been awfully good about the house here and all. Oh, it's no trouble. All the same. I know it isn't easy. Oh, I don't mind. Always used to out my mum about the house.  Didn't you Georgie? Yes I did. I wish you do. What I know she'd want you to do. If she was alive. What's that? Get away. Get away from the street. I know she's praying for that. Wherever she is. The street does things to people Georgie. Terrible things. Well, I will. I will get away one day. One day maybe too late. Maybe it will. Maybe it won't. Why don't you let me help you? I know she'd want that too. Do you really think she would? Oh, I know she would. Georgie please. No, no I said I don't want any help and I don't. All right Georgie. I won't see you anymore. Hand me my medicine please. What? My medicine. On the table. Oh, here you are. Thank you. No. Georgie. Oh, I'm sorry. I slipped, I did. Did you? Yes I... I thought you struck the glass out of my hand. No, no, I didn't. Anyway, it's no matter. I'll get you some more. Georgie. And then are you... you've got to get away from here. Get away? Yes, now. Today before it's too late. Perhaps it is too late. No. No it isn't. Not for you. I can't get out of it. I never will but you can. You've got money. You've got to go. Are you sure? That's best? I know it is for everyone. For you I mean. For your health. That's it. I was thinking about that your health. Oh, you'll never get well here. You'll die here. I've been prepared for that. For quite a while. Oh, I didn't. I'm not here. You've got to go. Promise me you'll go. Yes. Perhaps that is best. All right, George. I'll go. That night I slept. Really slept. For the first time in weeks. When I woke up it seemed late. I heard the sound of dishes down in the parlour. I jumped into my clothes in a flash and looked down the stairs. They were having breakfast. Coffee. I seemed to turn all sick inside. I ran down the back stairs to the kitchen and over to the cupboard. The boss was still there but... But it was empty. The poison had been used since yesterday. I ran out into the parlour. Oh, thanks. I'll think for real. Don't drink it. What's good into you? Just drink it. Tell me. My coffee? Why, yes. It's poison.   I knew he'd do it. He wanted me to. And when I wouldn't, he did it himself. But he won't get away with it, Edna. I've got to call the police. I'll get you a doctor. George. No.  Get her made some quick. I did not. Get them medicine. I'll tell you. I'll see to her. Medicine. She's dead. Dead? Oh, don't try any of that, Uncle Bert. You poisoned her. You didn't. And I know it. I looked at the box in the kitchen. And it's empty. And I'm going to the police. George. Well? I swear I didn't. I swear I... Oh, that's holy. She made the coffee herself. She brought it out. With her own hands. She did. George. Call the doctor. She's done for me. Call the doctor. Quick. That's it. You've been the ruddy mastermind so far. You get your own doctor. No. So long, Uncle Bert. Happy landings. I went next door and asked Mrs. Wiggins to call the police. Then I went back to the house. I picked up Edna in my arms and carried her to a room. Later on a bed. I smoothed out a pillar for her head as though she was still alive. Then I saw it.  And a note. Dear George. Don't be sorry for me. And don't think badly of me. I was wrong to close my eyes to things just because I didn't want to see them. But after yesterday I knew you were right. And it was best for me to go away. Give this note to the police so that they will know it was me and not you that poisoned him. I found a picture of your mother in the attic. She was so beautiful that I could see why even Bert couldn't really burn it like he said. Take the money that I've left and leave the street. But carry a picture with you wherever you go. For I know she will always be watching over you as she was yesterday. To keep you from harm. And so shall I. Your friend Etna. Suspense. Presented by Roma Wines. R-O-M-A. Roma America's favorite wine. Whether you're dining alone with your family or having guests for dinner.  To lend charming distinction to your table and enhance the hidden flavors of your favorite foods. Serve delightful grand estate California Burgundy. The ideal flavor mate for hearty foods. Red robust grand estate Burgundy brings out all the taste goodness of juicy roast beef. Temptingly enriches the flavor of steaks. Sizzling chops or even plain hamburger. No wonder to discriminating wine users. Grand estate wines are the crowning achievement of vintner skill. And all grand estate wines are distinguished limited bottlings by Roma America's greatest vintner. Each is born of choicest grapes. Then unhurriedly guided to rich taste perfection by ancient Roma skill. The magic of necessary time and America's finest winemaking resources. With tomorrow's dinner enjoy the rare taste luxury the gracious pleasure of grand estate wines. Presented by Roma the greatest name in wine. This is Roddy McDowell. I just wanted to say a few words in my own voice. It's been a very great pleasure for me to be able to appear on suspense. Thank you and good night. Roddy McDowell is currently appearing in the Metro Golden Mayor Technicolor production Holiday in Mexico. Tonight's suspense play was written by Sanford Schlesinger and Robert Richards. Next Thursday, same time, you will hear Mr. Van Heflin as Star of Suspense. Produced and directed by William Spear for the Roma Wine Company of Fresno, California. In the coming weeks suspense will present such stars as Glenn Ford, James Stewart. Make it a point to listen each Thursday to Suspense Radio's Outstanding Theatre of Thrills. This is CBS, the Columbia Broadcasting System.


Oceanography, Oceanography also known as Oceanology, is the study of the physical and biological aspects of the ocean. It is an Earth science, which covers a wide range of topics, including ecosystem dynamics, ocean currents, waves, and geophysical fluid dynamics, plate tectonics and the geology of the seafloor, and floods of various chemical substances and physical properties within the ocean and across its boundaries. These diverse topics reflect multiple disciplines that oceanographers blend to further knowledge of the world ocean and understanding of processes within, astronomy, biology, chemistry, climatology, geography, geology, hydrology, meteorology and physics. Paleo-sianography studies the history of the oceans in the geologic past.


I was sitting in Bush Intercontinental Airport in Houston recently, on my way to a small scientific conference where I gave a short talk on my current project. As I'm sitting, waiting for boarding time, a very large man sits down right next to me and pulls a cigarette out of his pocket, takes a long drag on it, and exhales deeply. I'm old enough to remember the no smoking warnings being a bit of a novelty, but I haven't seen anyone smoke in an airport in a few decades, so I admit I was shocked. The gate attendant sprinted over to, I don't know what she had planned, but there was murder in her eye. The guy smirks and says, that's not a real smoke, it's an electronic cigarette, see? No flame, no secondhand smoke. The gate attendant explained with poorly contained rage that the FAA and the airline both forbid the use of these devices. The guy looked equally outraged, but put the e-sig back in its case as he started debating federal policy with reference to nicotine gum, prescription drugs, and medical needs. People have been asking me to address the controversy surrounding these very new alternatives to smoking cigarettes. It's not an altogether easy topic to cover. There just isn't much data so far, and what little evidence does exist is contradictory on the health effects. The e-cigarette was first described in a patent attributed to Herbert Gilbert in 1963, but the modern commercial version has only been around since 2003, invented by Chinese pharmacist Hon Lik. In 2005 it was approved for export outside of China by a company called Ruyen, and the international patent was filed only five years ago. In such a short time they have really caught on, and are already presenting legislators with difficult choices. Should they be treated as drugs and devices, and regulated in the same way as medical inhalers since they do deliver nicotine? Or should they be regulated as a smokeless tobacco product, which in a way they are?  The U.S. Food and Drug Administration strongly suggested that they should be regulated as a combo of drug and medical device. Late last year they were overruled. Starting in 2012 e-cigarettes will be regulated in the U.S. by the FDA as though they were cigarettes, following much more lax requirements for manufacturing and testing. This benefited manufacturers because it keeps costs down, but probably doesn't do anything good for consumers. We should take a very quick detour to explain how they work. There are two main elements in the electronic cigarette. First, the juice, which is a solution of propylene glycol, or glycerin base, flavor, nicotine, and water. The propylene glycol has been used for decades in nebulizers with minimal risk, and the FDA rates it as GRAS, or generally recognized as safe. The second element is the mini vaporizer, which works by either heat or vibration to generate a vapor of the juice. The juice is inhaled by the smoker as vapor into mouth and lungs, where it condenses and is absorbed into the bloodstream. It all sounds like a safer, more convenient, less toxic way to avoid smoking those dreaded cancer sticks. The nicotine delivery works on a very different time scale than cigarettes, and the delivered dose is quite different. If we measure nicotine derivatives in the blood of a cigarette smoker, there's the initial spike within 5 minutes. The e-cigarette can take up to 30 minutes to reach that initial spike. The combustion product of cigarettes, and the particle size of delivery, is actually very different from liquid vapor delivery, so the e-cigarette is much more analogous to a nicotine gum or patch product. It's been suggested that the majority of the nicotine is actually being absorbed in the gastrointestinal tract, essentially drunk as the juice condenses, passes into the stomach, and eventually deliver. This is an important difference because the liver acts as a filter for toxins, wherein smoked cigarettes the lungs absorb the nicotine without passing first through that filtration. The second paradox is that the delivered dose can be highly variable in e-cigarettes, and they may actually be, if this is even possible, more likely to promote physical addiction to nicotine than cigarettes. What about secondhand smoke, or in this case vapor? Well, the exhaust of an e-cigarette doesn't contain tar, except when it does. That's right, in a few cases the juice was contaminated with some byproducts of its manufacture. The cheapest place to get bulk nicotine is from tobacco extracts. Sometimes those extracts aren't that purified, and some cancer promoting substances other than nicotine are copurified. The manufacturer acted very surprised when the lab tests were presented, but I suspect that it was not that unexpected. The risk is still relatively low in comparison to cigarettes, but higher than not breathing in secondhand smoke. What else is present in the exhaust of e-cigarettes? Well, nicotine, and really quite a lot of it. People around you can still be inadvertently exposed to an inhaled stimulant, nicotine. Nicotine is quite probably the most addictive drug produced by a plant. It causes long-term changes in neural plasticity, affecting learning, behavior, and possibly promoting other addictive behaviors. Unlike cannabis, where the gateway drug effect is not well supported, nicotine almost certainly promotes the development of other addictions, like alcohol and eating disorders. As a friend of mine who studies nicotine's effect on the brain describes it, nicotine makes you neurotic. That's because it increases the level of several neurotransmitters in your central nervous system. It stimulates the release of adrenaline and global changes in brain activity.  There's also a correlation to schizophrenia and some other conditions. I would prefer that if you're addicted to cigarettes that you could stop cold turkey and simply never start again. I know that may not be practical. Research shows that nicotine replacement therapies can be effective at helping you quit. That leads us to the final question of this video. Are e-cigarettes effective at helping people quit their addiction? The evidence so far is inconclusive. People certainly substitute the e-cigarette for the cancer stick once they pick it up, but it's still unclear if they can wean themselves off the substitute. I think in summary, you're probably better off with nicotine replacement therapy, not e-cigarettes. If you're interested in quitting, try the gum, the inhaler, or the patch. Talk with a physician and take their advice. E-cigarettes might end up as a safe alternative with better regulation, further technological improvements and more research, but right now they're probably not a great idea. Keep in mind that they still aren't safe around kids or the elderly or people sensitive to nicotine. What worries me the very most about this new product is the hipster angle. I'm worried that they'll become a popular new trend. Health agencies, medical organizations, and government have been combating the rise in smoking with great progress over the last few decades. Fewer and fewer kids are making the big mistake of picking up a lifetime habit. I would hate for some new marketing spin, some new media campaign, or underground movement to reverse all that progress. It's estimated that smoking in the US results in $160 billion in healthcare costs, lost work or productivity, and indirect effects to say nothing of the grief of a family that loses mom or dad too soon to lung cancer, COPD, or heart disease. I'd support any legislation that promotes updated education for the general public, but especially school-aged kids, about the dangers of not just smoking, but also other nicotine products. If you have a young person in your life, take a minute to talk openly and honestly about why smoking or other addictions are a bad thing. Immaturity and the kind of bad choices we all make at that age shouldn't have lifelong consequences, but they do. Do what you can to educate them so they can see the path ahead. Do it honestly, but do it now. Thanks for watching.


Following is a presentation of TFNN, The Trader's Edge with Steve Rhodes, toll-free at 1-877-927-6648, or internationally at<PHONE_NUMBER>. The Trader's Edge. Now, Steve Rhodes. Good day, folks. Welcome to the January 14th, the fantastic Friday edition of today's Trader's Edge show. I'm your host, Steve. Perseverance Rhodes, who absolutely knows that each of us should always be pioneers of our future versus prisoners of our past. Hope everyone out there is having a great day. Let's make sure we have an extraordinary one. And the easiest way to do that is to always remember that life is happening for us, not to us. That's right, we need to now make that one little two-by-four shift. Well, it means we can find the gift and every set of circumstance that life is going to toss at us. Now, today, you and I, we're going to go check on the circumstance of these markets. We'll go figure out what those bulls and bears, what those buyers and sellers are communicating to you and I at just past eight o'clock in the morning. That's right. If you're listening live at one o'clock, thanks so much for doing so. We are recording today's show between eight and nine. We're going to make it as pertinent as we can for you while you're listening at one to two. And if you aren't listening live, listening live, we would love to hear from you. So a couple different ways to do that. You can always give us a call<PHONE_NUMBER>. If you can't call in, we've got another way. You can send me an email. Send it to Steve at TFNN.com. Now, inside that subject heading, if you'd be kind enough to put radio show question, that way I can pick out your email, which is important to me versus all the trash that, you know, each of us get each and every day in our email system. Of course, the third way would be if you're inside our Tiger's Den. We would love to hear from you there. You can be a private ping. Public ping does not matter. So let's go ahead and get this show started on fantastic Friday. Of course, this is Tiger, Financial News Network. I'm Steve Rhodes. Welcome to Lush Show. Right now, we've got Sea of Red out here. Sea of Red is not just in the U.S., but across the board in Asia and Europe. So last night, you had the Shanghai finish down 35 points in the EKO 364. That was a little over 1%. Hang saying was up 2.10%. Right now in Germany, the Dax is down 162 points. That's 1%. The FTG is stronger than that. The Dax, only up 3.10%. She's trading out at 75.40%. We'll go see what all that means. In the U.S., we've got U.S. equity futures trading lower. The Dow down by 203 right now. The Nasdaq 130. The S&P 29. The Russell 2016. Gold is up a buck. Silver's down 19 cents. Lights Recruit is trading out at 81.44%. That's back about 20 pennies as we speak. The 30-year Treasury down 12 ticks, trading out at 150.605. So, where do we want to begin? I suppose you probably want to begin with the U.S. markets. I'll tell you where we begin. We'll begin with what I usually do as a market update. I'll do this at... I'll do it. I'll tell you where we're going to begin. We're going to begin with our first caller. And that is Brent in Martinez, California. Brent, thanks for calling. Thanks for holding. How are you doing today, this morning? Good morning, Steve. I'm doing well. How are you? I'm doing excellent. Nice to hear your voice early. And so, I believe you called about to discuss the end cues. Is that correct? Yeah, here we are another Friday where there's loads of potential for... And I like to do these trades that are the weekly trades on that, on the options that did my gold trade yesterday. So, I'm just looking at, you know, if we're getting down on the, on the keys to, you know, that Monday lower, you know, into that bar anyway. So, I just wanted to get your thoughts on, do you think this is, potentially, that was the B to C leg up? And now we're going to surpass that? Well, I think it's going to be lighter volume in my mind, just looking at what I saw this morning. But just want to get your thoughts on that. And if there is any kind of potential setup on the, you know, shorter term charts here for a potential bottom in the NASDAQ? Sure. Okay. So, let's try to answer that question first. So, I'm just going to switch panels here. Give me a moment. We'll go to the eight-panel multi-time frame chart for us. So, and we'll be able to answer that question fairly easily, I believe. So, Brent's question was, he's looking for some type of setup to potentially go long. And so, to do that, what we want to be able to see, folks, is some type of bottoming signal on the intraday timeframe charts. So, the very upper right-hand corner, last night, about 10 o'clock, in fact, at 10 o'clock, we got the confirmed rogment-dominicator signal that led to a bounce. We expected that bounce because of yesterday's one-day rate of change above plus 10%. Now, this morning, we can see that that pattern has failed. I'll just put my, I'll just actually expand out the chart here, make it a little bit easier for people to see. So, you can see, so the reason why yesterday's rogment-dominicator signal was confirmed was because at 10 p.m., we got that nice little bullish piercing candle. There was a new profile that formed right after that out here. So, now what we know is that pattern has failed. And Brent, in order to get some type of bottoming signal on a 30-minute timeframe chart, we would need to see there's there's still a rogment-dominicator signal triggered. But what I would want to see is some type of bullish reversal candle. Now, it's possible that we get that by 8.30 this morning. Price has to close probably at about the 1,500-ish type range out here, about halfway into the bar, that would give us another piercing candle out there. So, we don't have that as we speak at 8.11 in the morning. If we look at the other timeframes out here, the other inter-day timeframes, the 60-minute chart had a TD9 count bottom pattern. That failed. So, I don't have anything here. Although, I do see that on a 60-minute basis, we are in wave number seven. And so, that just simply needs a higher low to form out there. So, that's a potential for a bottom. With regard to the 120-minute timeframe chart, so the 240 or the 300, I don't see any bottoming patterns coming off of the highs from yesterday as an example. So, if we take a look at the five-hour timeframe chart, that had the best topping signal yesterday. That was a TD9 count. And then price at about 10.30, 11 o'clock in the morning just went ahead and had that Nike swoosh to the downside. And right now, price is testing the breakout level, which is at 15.403. So, if price can hold above that, now this current candle on a five-hour basis, I think this does not close until 9 o'clock. So, Brent, look at 9 o'clock. If price holds 15.403, that might be a signal to us. Now, price might be just coming back and testing the lows of Mondays. Brent pointed out. Now, Monday's candle is a hammer candle. And so, Brent, that's going to be really important, that low. And that low specifically is priced at 15.150 to 50. So, if price closed below that, you know, we have that expression around here. If you are long, you're wrong. If you close below the bottom of a hammer candle, now that might be support. So, we don't know if that area is going to hold or not. You had mentioned light volume. And so, with regard to the volume, the easiest metric that I have to take a look at the volume activity is just simply to go the index ETFs. So, I'm going to switch screens here for a moment. We go back and forth and you can ask questions, but just trying to answer the questions that you have or maybe pose questions in people's minds out there. So, if we take a look at yesterday's activity, and here's the chart that shows us each of the index ETFs, that being for the spy in the upper left-hand corner for the S&P, for the NASDAQ winner, the Q's in the upper right, the Dow diamonds in the lower left, the IWM for the Russell 2000. So, if you look at the yellow horizontal lines on my screen out here and the volume level, you'll see that price was pulling back into those swing points, a swing point that is being tested as we speak right now for the daily timeframe for the NQ. But here in the index ETFs, everything was pulling back on lighter volume than that of Monday. What I don't know is what today's volume might be. The other thing to note inside the spy or the NQ was prices also pulling back to the bottom of their daily profile levels. So, if those areas fail, that would suggest a lower price out here. So, from a volume standpoint, you're absolutely right. At least that was as of yesterday. No idea what today's volume might be. But it's got that potential that you're looking for, and that potential would be best used if we could get some type of bottoming signals in these intraday timeframe charts. Brett, we're going to a break here. Please do me a favorite hold on. We'll come back to you, and I want to answer any questions that you've got. This is Steve Rhodes with Brent in Martinez, California, 8.14 in the morning, thanks for listening live if you are. As always, the recorded show will be back in just a few moments. What's separating you from the most successful men and women on Wall Street? That's right. Information. Having all the information gives us the perspective we need to place the right trades at the right time. The TAS Profile Scanner is the premier market profile based scanner. 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From the price you should be paying per square foot in certain up and coming areas to the type of cash flow investment properties are capable of creating, Tiger Real Estate can help you make the best decision when it comes to all areas of the market. Before you make one of the biggest decisions of your financial future, call Tiger Real Estate LLC today at<PHONE_NUMBER> or email us at tiger at tfnn.com. That's<PHONE_NUMBER>. Call us today. Sharpening your skills as an investor is like getting better at playing a musical instrument. You have to practice, sure, but you also need excellent instruction from experts. At TFNN, you'll get advice and guidance from the authority in technical market analysis, and it's not just dry tedious text either. TFNN airs live financial content streamed live on TFNN.com and TFNN's YouTube channel with Tiger TV, live every market day from 8.30 a.m. to 4.00 p.m. Eastern. For free, each host is an experienced trader and gives their take on the market while taking calls and questions live from around the world. From the moment the market opens until the closing bell sounds, Tiger TV has eight different shows with expert hosts to help you make the right moves with your money. Watch online at TFNN.com or on TFNN's YouTube channel and become the investor you were born to be, TFNN. Educating investors. Call now, toll free at 1-877-927-6648 internationally at<PHONE_NUMBER>. Welcome back folks, we're online with Brent de Martinez, California. We're ripping apart the NQ in that first segment. What we determined was there was no confirmed bottoming signal on an interday time period to suggest that Brent or anybody else out there might pull a trigger. However, if we take a look at, so Monday's candle in the NQ was a bullish hammer candle, and if somebody were to ask me the question, if you've got a hammer candle and price moving into it, where is the best place to go ahead and put a long trade in, my answer would be somewhere between the middle of the wick of that candle and the bottom. Well if we take a look at from the low of the hammer candle from Monday up to the rally into Wednesday, what we will see is that price has made its way back to 0.786 retracement. So although Brent, I don't have any kind of bottoming signal per se on the interday timeframe charts, this certainly would qualify as a reason or a logistical reason for you to consider taking that trade. So I just wanted to throw that out there as well. And if price doesn't hold this level, the 15335-ish range, then price should go down and test the bottom of that hammer candle at 15152. So given all of that, what questions has that posed in your mind? Which charts would you like me to go back to or to take a look at with you to answer any further questions? No, this is great Steve, as always. But I'm pretty confident, at least what I've been seeing so far this morning is going to be lighter volume going into this low. And that doesn't mean it can't surpass that, but at least that part of it I'm pretty confident in. As far as being a bottoming pattern, that I'm just going to be following and watching. And we've had, you know, some good movement. We saw what happened Monday, doesn't mean it's going to repeat, but it got driven down there.  That's what I'm going to be looking for. So yeah, so here's, so on Monday, so just to kind of go back to Monday's low, because that was taking place as I was coming on the air about 15 minutes before it actually came on the air. So I just want to go back to one set of charts out here before we, before we leave you for the day and the week and just to point out what was also occurring then. Not saying that that's going to occur now, but it might. And that was it on the 30-minute charts out here. So I'm going to pull the, I just, I was hoping I could show it in an easy way, all four charts, but I've got to come back here. So on Monday, what was taking place at 11 o'clock in the morning was we had a TD9 count bottom, a seventh wave move bottom, an erosement, a indicator bottom. And Brett, that was occurring on each of the 30-minute time frame charts in the equity future contract. I mentioned as we were coming on the air, and that was here at one o'clock. So this is where my candle is right then. So we had the bottom signal, price pulled back into that bottom signal, very much like we're seeing take place with price pulling back in that hammer candle. And then it just simply took off. So that was the retracement. So ideally, you'd get that type of, at least some type of bottoming signal on the 30-minute time frame charts. We don't have that as we're taking a look at right now. But that might unfold, you know, before the market opens. So I hope that all of this helps you out and everybody else that's listening, because I know they also are trying to figure out which way are these markets going to go today. Is there anything else that I can provide to you? No, that's great to go back and look at that piece that I do. I was, of course, listening to you that day. And that was a great call, at least, you know, highlighting that that was happening. So yeah, the other thing, the other interesting thing here, we're having a good volatility. There's no question about that. And given opportunities, both ways say this has to be certainly a little nimble, maybe more so than, you know, at other times, but there's a lot of opportunity out there. And this has to be, you know, of course, paying close attention to the, I think the shorter term stuff is pretty critical at this point. Yes. The other interesting thing that took place this week so far, and certainly on Monday, and take a look at the NQ, is if we look at the weekly chart out here. So on the weekly chart, so whenever we close above, especially if it's a bearish structured profile, in this case here, it was a weekly bearish structured profile. And the week of October 18th, price closed above that. We need to see two closes above the level of resistance to suggest that it's really a breakout. Well, you got that the very following week, and then price went up, you know, and made its high so far that November 22nd, that day, I believe, or maybe it was, yeah, November 22nd. And then when you close above the top of a bearish structured profile, if the move lower is only a countertrend move, where price will find support is at the center or the top. It's typically the center of that profile. Well, the center of the profile for the NQ is at 15104. The low that we saw on Monday was at 15152. So really very close to that level, about 48 points away, but we can see that that is held. Now, if we get a close below 15104 today, folks, what that suggests to us is that we should see a move down to the 14804 level that would also, on a daily basis, then likely generate an A to B equal CD to the downside, even if it is with light volume. And that gives us price projection of 14502. So we'd say, if the 15104 level fails, we would expect or anticipate a move to 14502 to 14804 level. So I just thought I'd finish it off that way, Brent. If there's no other questions, thanks for listening to my blabbering out there, and have a great weekend. Yeah, you covered all of it, Steve. That wasn't my other question about, was that potential to be the C leg that we've been going through the last three days? It's possible. We're going to find out, I think, today potentially. Yes, yes, yes. Well, we'll find out soon enough. So, hey, Brent, thanks for waking up early, spending time with us this morning. And we'll look forward to speaking to you hopefully next week sometime. All right. Thanks so much, Steve, to have a great rest of your day and a great weekend, and I'll talk to you soon. We'll do. We'll do. We've got a question coming in from the Tiger's Den, and that is from Ruby. And Ruby wants to take a look at the US dollar index out here. So let's go do that for her. We'll do this a couple of different ways, meaning we'll take a look at a couple of different sets of charts for her. So I've just got to find my first set of charts out here, as long as we're on this screen. It's right here. Okay, here we go. So we take a look at the US dollar index. What do we know? Well, we know a couple of things. Maybe it's easier if I turn off some of these trend lines. So give me a moment to do that. Just make it a little bit clearer. But what I'm going to say is what we do know, Ruby, is that price has closed below both the bottom of the daily and the weekly profiles out here. Uh, no, but I want to turn that off. Oh, what did I do? Good Lord. Okay, good. I thought I pretty much just screwed everything up there, which pretty much I did. Okay, so now we can see the upper charts, what we're looking at here, Ruby. So price is below the bottom of the daily and the weekly profile. Now, right now at 8.25 in the morning, we've got a hammer candle that is forming, but then who knows what it's really going to be. And there's, there's certainly an A to B equal CD to the downside. So Ruby, the first thing I would say, I'll show you that A to B equal CD pattern out here. So first, let's take a look at this for the A point. I'm going to use the high from the trading day of December 15th. And for the B point, I'm going to use the low from December 31st. And the C point is going to be the retracement into January 1st. So we're at the one to one level out here. It was a 68% retracement. And so Ruby, if you were to get a bullish reversal candle today, then the US dollar index would generate a currently buy pattern. I don't know if that's what we're going to get or not. Yesterday's candle was not a hammer candle. Today could be, but we're too, we're too early into the session to know that. Now, if we don't get a hammer candle or bullish reversal candle today inside the US dollar index, then that would suggest on the A to B equal CD price projection level that the next target area would be 94.34. 93.67 is the center of its bullish structured monthly profile. So that all makes sense. So that would be the downside target that I would be looking at Ruby, unless we see some type of bullish reversal candle. Now what I'm going to do here momentarily, we're about to go to a break, but I'm going to switch over to the currency pairs that make up the US dollar index, the euro, the yen, the pound, the Canadian dollar, the Swiss franc, and the Swiss corona, the Swedish pronoun there. So this is Steve Rhodes with TFN. We come back, we'll finish looking at the US dollar index for Ruby and the Tiger's Den. Are you looking for a way to consistently add winning trades to your portfolio? Tom O'Brien is here to help. Tom O'Brien has been successfully trading markets for over 30 years. A frequent contributor to TD Ameritrade Network and CNBC, Tom O'Brien found a TFNN over 20 years ago to help educate investors just like you. Tom's Daily Market Newsletter, Market Insights, is published every morning when the markets open to give you the competitive informational edge you need to succeed. These newsletters are packed full of Tom's advanced technical analysis and are geared to deliver comprehensive strategies for a successful portfolio. Get Tom O'Brien's newsletter, Market Insights today, and try all of our products and newsletters 30 days risk-free with our money back guarantee at TFNN.com. TFNN, educating investors. You could be making a lot more. Check out TFNN and Tiger TV and get expert investing advice to give you the power to control your financial future. Go to TFNN.com and find the newsletter for you. Whether you're into trading gold, metals, futures, currencies, or options, you'll get advice and analysis to help you seriously get ahead. TFNN also features trading services with a 30-day money back guarantee for new subscribers as well as TFNN's Tiger N trading room, trading software, and educational webinars for all trading levels. And make sure you check out Tiger TV for free on TFNN.com or TFNN's YouTube channel for live financial content from 8.30 a.m. to 4.00 p.m. Eastern on market days.  TFNN, educating investors. Formation setups, including guardleafs, ABCs, butterflies, and much more. The art of timing the trade charts is designed to help you when scouring the markets for stocks just beginning to form the trading patterns that many investors spend days, weeks, or even months searching to find. And right now we're offering licenses available at only $79 a month. We are so confident that you're going to love this new charting software that will even give you a 30-day unconditional money back guarantee. Don't miss out on this incredible new piece of software. Get your copy of the art of timing the trade charts today by visiting TFNN.com. Welcome back, folks. So we're taking a look at the U.S. Dollar Index. And the bottom right-hand panel is the right-hand corner is that instrument. So here's what we know. We took a look at the potential for an A to B equals CD. In order for that to happen, we need to see a bullish reversal candle today. If that does not occur, another price target level would be $93.81. That's its TD9 count to breakdown area. So we can see it formed an erosement of indicator top. That was this bear sash candle out here that was on the trading day of, give me a moment, the trade day of December the 15th. So these currencies are what make up that basket of, these are the basket of currencies that make up the U.S. Dollar Index. So we start with the euro, which is, I don't remember what the percentage is out there, 57% something like that. We don't have any kind of a topping pattern out here. Of course, like the dollar shows a hammer candle, the euro shows a bearish shooting star. All right. So it's really the euro that is primarily controlling what the U.S. Dollar Index is doing. So although I'm sure I can draw an A to B equals CD, so if we do get a bearish reversal candle in the euro, which could be a shooting star, that would mean we'd have to see basically no activity for the rest of the day, then you'd have a Gertle cell. The dollar would have a Gertle short of that, the euro is likely targeting the 1.16 level. That is its TD9 breakdown area. Now, the Japanese yen is targeting the 1.1355 level. That is its TD9 count breakout area. If price closes below that, that suggests that we go back and revisit, tough for Stevie to say that one this morning. I don't know why, it must have been the water I'm drinking here. But we would revisit the December lows. If we take a look at the Great British Pound, this has formed a sell the D point pattern. Yesterday was a bearish shooting star, a TD9 count pattern. And we could see that it's oscillator on change line, change colors, you know, a couple of weeks ago, actually. Now that we've got the valid topping signal, we should see price and that line catch up to each other. So the Great British Pound should get weaker. And if it doesn't get weaker, it indicates the pattern that's going to go up to its TD9 count breakdown level at the 1.38 area. But it should get weaker and pull back to that oscillator and change line. That would put strength in the US dollar index. If we get that topping signal in the Euro, that should put help to create a bottoming pattern inside the dollar. The yen has been strengthening. So if it finds support at 1.13, it starts to move higher, it will weaken. The US dollar index will get stronger out there. You got the Canadian, the dollar, the Looney back at a breakout level of 1.24. So Ruby, I hope that this helps you out with regard to the US dollar index. It's important, I believe, to take a look at what the other currency pairs. We don't need to really spend any time on the Swiss franc other than the fact that it's back at a support level. And that is its TD9 count breakout level. These two currencies, the corona and the franc, are only about 6% of the total of the US dollar index. So it's really the top four that we want to focus on. It doesn't hurt to know what the other currency pairs are doing. But that's our US dollar index. I hope that helps you out. I also know you wanted to take a look at the 30-year treasury. So if you wanted to look at it, others want to look at it as well. And here, as we take a look at the 30-year treasury, in the upper left-hand corner is the daily time frame. And it has confirmed, yesterday, confirmed a buy the D point pattern. So we've got the one, this generated one to 1.272A to B equals CD pattern. Yesterday was a bullish engulfing candle that wrapped around that little doji candle from the prior day. So what this would suggest to you and I, Ruby, is that the 30-year treasury, because of that confirmed bottom signal, should at least make a run for the top of it, a daily profile. And that's at the 1.5718. Doesn't say that that's what's going to happen today, but that's a signal that was generated yesterday. And the other element that you've got here is you know you've got support at 1.5506. So I don't see anything else on the 30-year treasury side to really assist you. So you've got that confirmed bottom, price should go target the 1.5718 level out there. So I hope that that helps you out. Thanks so much for the request this morning. We do have requests that came in by email. And so I just simply want to get to that. Don't want the time to slip away. And that was coming from Hector. And Hector wanted to take a look at your welcome, Ruby. And Hector wanted to take a look at AIG, which is what you've got up on the screen right now. Now Hector had specifically asked me to draw in an A to B equal CD pattern. If I open up, which I'm going to open up this daily timeframe chart out here. And you know there's many A to B equal CD patterns here that we could come up with. But really what stuck out to Stevie was more of a consolidation pattern. Now I don't know if this is going to end up being a consolidation pattern or not. If price does not take out the high from the trading day of November 5th, that high out there was $62.54. If price does not take out that high, then we likely have a consolidation here. And again I'm looking at the daily timeframe. Now there is a new profile that formed yesterday. That new profile Hector formed below price. That's a bullish message. But if this is, and price was moving into the swing point, that swing point I'm referring to November 5th that had volume of 6.7 million shares. And yesterday you were up with 3.4. So it doesn't seem like it has the volume to push through this area. And therefore AIG would suggest to me that price would pull back to the 59.82 to 60.12 area. That's what the daily timeframe chart shows us. If I try to come up with a A to B equal CD pattern for the weekly timeframe, and I would, here's what I would look at. And that would be the A point down here from March of 2020, the B point out here being June of 2020, and then the C point being a September 21st pattern. So now you can see we're up at the 1 to 1.618 area out here. Are there other A to B equal CD patterns that we could draw? I'm sure that would take us much higher than that. But I'm really not going to draw those patterns in Hector. And primarily I'm not going to, because we need to see if this consolidation pattern forms, holds or what it does out there.  So back to the daily timeframe. And on the daily timeframe, so 62.54 was its TD9 breakdown level. I didn't actually have this chart open. So I didn't realize that we actually had a TD9 count top or pattern that formed yesterday. You could still have a higher high today and maintain that pattern. So here's the cool thing. If you're in AIG, you love this pattern. Well, you sort of love it because you're at a stage here where you've got a valid topping signal at a prior high, moving into a lighter volume at a TD9 breakdown area out there and an oscillator and change line that has changed colors. So everything is really set up for a pullback. Turns out that that oscillator and change line is right at the center of yesterday's barestructured profile where we would expect a counter trend rally to find support. So at this stage here, Hector, even though I don't think this is exactly what you were asking for, what it looks like to me is that AIG is going to go ahead and pull back. Now the cool thing is, whether it's yesterday's high or today's high, whichever one of those two is the highest high. If on Monday price closes above that, it'll negate these patterns. You can forget everything that Stevie said.  We're just interpreting what the message of the markets are. So it looks to me, Hector, like AIG is getting ready to top, pull back, and if it can hold that green oscillator and change line, it will maintain a neutral type of a signal out there. So hope that helps you out. And thanks so much for the request. John and Philly's typing in. This is a Philly. Your choice, if you would like to talk to this. Oh, that's all. Do we have John online? Is that what we have? Ah, perfect. John, thanks for calling. Thanks, Rowling. Sorry about my inability to read a message and know what it actually means. That's early. That's a bound, sir. Snap who's a bound. Exactly. Exactly. That's okay. We'll recover quickly. Steve, I wanted to follow up upon the discussion. You just had with Brent from Martinez. Specifically, as I'm looking at the NASDAQ Futures contract with this nice little flush that hit at 730, my chart work and yours, of course, shows that this is leg G lower on the 30-minute part chart. Hey, John, I didn't realize we're so close to the break. Do me a favor, just hold the thought for about three or four minutes and we come back. The mic is yours. This is Steve Rhoads with John and Philly. We'll be back in just a few moments. Being fun, trading the markets, but having trouble finding like-minded individuals to discuss your trading and investment ideas with, become an Apex creditor in the trading markets and join the Tiger's Den trading room only at tfnn.com. The Tiger's Den is an exclusive trading room where successful traders from around the world come to exchange trades and ideas. Join the den and surround yourself with the sharpest minds in the trading world. 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I've got other intraday time frame charts out here so you can see on the 15 minute chart you've also now there you've got a confirmed seventh wave move. You've got that same thing on the 10 minute chart and on the 5 minute chart and on the 60 minute time frame chart. So this market on the intraday basis, John, and you picked it out, you are the conductor here, definitely singing in the key of G. So the floor is back to we shift the floor or the microphone back to you. Yes, thank you, Steve, for that detailed discussion. A bottom line question that I'll pose after 60 seconds here first, by way of background, trading from a position swing trade actively, reason being since that November 22, NASDAQ 100, we've got a pattern of lower highs, excuse me, lower lows and lower highs. We haven't busted any major support as of yet as your work clearly documents, but my suspicion is that that in fact happens, that we bust supports. I'm thinking in my mind of stuff that of ideas that were first highlighted and brought to the attention of listeners on TFNN by Stan Harley back November 4 time frame in which he showed there was a interesting developing between the NASDAQ here in 2021 and the NICI 225 back in 1989. And thus far here in 2022, that analog be repeating at least for the moment, that doesn't say anything about next week, next month. Sure. My suspicion is on those rich, highly valued, over-owned tech names for their decline. We'll see if that happens, of course, but with that as background, we've declined since Wednesday on the NASDAQ features up there at the 16,000 mark. And with that 30 minute bar chart forming a Chapman wave with that patented Saratoga Bob peak, excuse me, TROPG bi-signal as a VentoFib 786 support mark on that futures question, the NQH2s, where does it need to suggest, hey, this low right here down at 15, 3, 10 area will stand for more than a couple of hours. Good question. Okay, so you pose that question to me and I'm just going to try to answer that question and take a look at these charts out here. So the first level that I would be looking for, and I'd really like to take it off of the 30 minute timeframe, John, would be the 15, 389-ish area. That's that red oscillator and change line. So at a minimum, that is where price needs to close above. Because we've got that seventh wave clearly on the 60 minute timeframe chart as a well out there, its level is at about the 15, 417. So you got 15, 389-15, 417. If price can close above that, that would be a signal of at least a further rally. Now that further rally, the key area of resistance there, John, and the reason is that I'm choosing the 60 minute timeframe chart. And the reason that I am is as I take a look at charts and try to answer a question like that, what I look for is where our resistance levels that have been tested that have held. And the one that sticks out to me that is clear that held was the top of the profile on the 60 minute timeframe. Folks, that is the upper right hand corner chart. In fact, I'll just simply expand this out. That way we're all looking at the exact same chart. And we can see that the rally that took place overnight ran into resistance at 15, 541. So we got the intraday, the 30 minute timeframe chart last night at time at 10 o'clock generated the rogment to indicator bottom signal. But on the 30 minute chart, it doesn't show why did price stop where it did. So I'm just going to size this down again. So because price actually had traded above the top of that profile that was present at that time. So there was no logical reason that I could come up with why on a 30 minute chart did price stop there. And it's one of the reasons why I have these multi-time frame charts because I'm looking for different areas of resistance and where is a key resistance level that held. And so John really goes back to that 60 minute time frame. So the real answer to your question is where would price have to close above to suggest that there's really some legs and this is just not a counter trend move would be for me right now I'd have to say is 15, 541, 95. So 15, 542 would be the number. Does that make sense to you how I came to that conclusion? Steve Oh, that's all I need to know that that's the bottom line. And third discussion thereof. So thank you. You're welcome. And always good to hear from you too, John. So have a fantastic weekend and we'll look forward to seeing you tomorrow. Thanks for sharing with everybody in the den as you always do. That was John in Philly. So I do have another question that has come in. Right now we've got Dow futures down 265. S&P futures are down 37. Nasdaq is down 140. But we've got a question here from Tim M. So let's get let me change charts here. Give me a moment or change screens, I should say, and we'll get over to the black background charts. We're going to go ahead and put the instrument that he's looking for, which is ACLS. That is Excelsis Technologies. Now just give me a moment here to pause. And the reason is I want to get my other charts up on the screen so that I can get this symbol input and we can take a look at a daily, weekly, and a monthly set of charts here, an ACLS. So I've got that going. Those will get updated. So the question here from Tim is could you please take a look at Excelsis Technologies from the daily and weekly perspectives, looking to take a long position when it looks ripe for the picking out here? Well, so you've got a brand new daily profile that formed yesterday, Tim. And so the support level or an area to be considering would be $65.27. Closed yesterday at $67.40. I know what's doing in the pre-market, but that would be an area to be looking at. Price is right now above the top of its weekly profile. And we're going to go in a moment and figure out if there were any kind of bottom signals out here for ACLS. So but price is above that level that, you know, even if there is a topping signal would generate a neutral position. Now, that would change, Tim, if you get a close below $67.19 today, that's the top of that weekly profile. So the weekly timeframe charts, what do we know? What we do know here, the daily timeframe, this top with a TD9 count and a roadsman to indicator signal. And price did exactly what was supposed to do. It pulled all the way back to where it broke out from. So that took place on the attempt. That was three days ago. That was at Monday. Yeah. So that was Monday out here.  That was your buy point. You were looking for a buy point. Now here's the good news. That was the good news. Here's the bad news. Perhaps you get the bottom signal out there. Again, price point back to a breakout level. What's price do runs right up to that oscillator and change line that's at $71.89 and pulls back. So where are we really at? Really a kind of a neutral position. If you want to take an attempt at a trade here and be between $64.50 and $65.21 and a price close below $64.50, 10, I would exit that position and say, no, that pattern doesn't look right. Maybe this is going to form an A to B equal CD to the downside. We get back. We'll finish looking at ACLS. Be right back. The reality is that navigating financial markets can be risky. Markets can be chaotic and difficult to understand. Having the latest market advice can help you turn this chaos into a key for creating winning trades. At TFNN, we understand that it can be hard to find reliable market news. That's why each of our market experts offers their very own market newsletter. They must have tool for every trader out there striving to find an edge in today's markets. 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Interact with other Tigers and Tigers as they share trading ideas, news analysis and discuss the market action all trading day. Subscribe to the Tiger's Den risk-free with our 30-day money-back guarantee and become part of the TFNN trading community. TFNN, educating investors.  The Tiger First Mortgage Program may be the program for you. The best rate on a five-year CD in the country right now according to Bankrate.com is paying 1% per year or $1,000 per 100,000 invested. The Tiger First Mortgage Program pays 7% per year, paid monthly on secured, high-value, billable properties in St. Petersburg, Florida. The investment is for four years, paying 7% per year or $7,000 per 100,000 invested. Your investment is secured by high-value real estate in St. Petersburg, Florida. Your investment can be anywhere from $100,000 to $500,000. Do you want to make $1,000 per year on $100,000 invested or $7,000 per year on a secured Tiger First Mortgage? The Tiger First Mortgage Program may be just the program for you. The Tiger First Mortgage Program pays 7% per year, paid monthly. For more information you can call<PHONE_NUMBER>. That's<PHONE_NUMBER>. Go to tfnn.com and hit Watch Tiger TV. That's tfnn.com and hit Watch Tiger TV. Welcome back folks. We're taking like an exceller set technologies out here for Tim Am who's looking for an entry point. So yesterday the pullback out here was with lighter volume. The volume from January 10th was 584,000 shares. Yesterday it was 431. Price still closed inside that. It looks to me like price at least go tag that 65-27 level out there. But if price begins moving lower or if price takes out the swing point 6390 that was Monday's low, then that's going to set up an A to B equal CD to the downside. That could set up a Gartley buy pattern. What we'd be looking for there, Tim, is for that pattern to then generate some type of bullish reversal candle as price approaches either the 5930 or 5557 level. That's not the message that we have right now, but I think you've got to kind of watch how today trades as well. I don't know what this tracks out here. So I want to understand the index that is tracking to understand what that index is doing as well. So I do hope that that helps you out, but we've got a minute to go here. And if you are listening live, thanks so much for joining me early this morning. And if you're listening at the normal timeframe, I hope that this show is helpful to you. Overall, the most important levels to be watching today, and I just want to give those to you, are going to be the bottom of the weekly profiles. The most important one right now I would say would be the ES mini. And that's at 4549.25. If price closes below that for this week, of course, we would need two consecutive closes below a key level of support. But if price did close below that today, it is generating for us a change in trend signal similar to what we saw, but not exactly the same, but similar to what we saw back in February of 2020 when price closed below the bottom of that weekly profile. So that's the real key area to watch. The other key area I would say would be on the NQ, the bottom of its weekly profile is 1480458. So those would really be the things to watch today at the end of the day. And certainly you'll have a better feel come close to two o'clock if you're listening at the recorded show. So folks, I want you to have a fantastic Friday, a fabulous weekend. And I'll look forward to seeing you again on Magnificent Marvelous Monday. Take care. Thanks so much for joining us.


Hey there lads and ladies, it is Petrifying Pumpkins here and today I am bringing you a very sad video about Firewall, about First Contact Entertainment, happened a few days ago, I'm sure many of you know it by now, but First Contact Entertainment as a business, as a studio, as a developer are no more basically, at least by the end of the year, which is just a few days away now, they will be closing their doors, they will be out of business, the people working there will be looking for new jobs, I hope that they all find them by the way, and the future of Firewall Ultra is completely up in the air, we don't know what's going to happen, we don't know where we go next, so basically on the 22nd of December, just a few days ago, Frank, who you might know as the community manager and he also, I think he transitioned into a different role later on in the studio, he put out a twist, Trevor put out a twist and of course, Hess Barber himself, the CEO of First Contact Entertainment also put out a twist, they all confirmed us, interestingly the official First Contact Entertainment Twitter account didn't actually put out a twist, so I don't know what the story is there, why it was just individual accounts and not the actual, the official account, there might be a reason for that, I don't know, basically all confirming that, you know, it was happening, it was closing down, Hess mentioned as well in one of his posts that the main reason was for a lack of support for Vior in the industry, now some people have interpreted that as him blaming the players or whatever, but I think it had more to do with the more directed towards Sony or maybe something like that, how they weren't supporting them enough maybe, now of course Firewall Ultra had a very rough launch and needed a lot of work and the most painful part of all this closing is that they were getting there, I believe, you know, updates were coming out four months since it came out and that's another thing as well, it's only out four months and already this had to happen, but in those four months we got update after updates, some of those updates especially the early ones did introduce more issues which was a shame but I feel like the latter four or five updates did improve the game for the better, it's in a much more polished states now I would say, anyway like I was trying to say before I got interrupted by some young children I feel like the last few updates really have improved the game and if the game had released back in August the way it is today I think maybe things would have been a lot better, maybe, I mean we'll never know, we don't have magical powers, they can see alternate timelines or whatever but it kind of feels like it's in a much more acceptable state today but the hard thing is knowing that more updates, more improvements were coming and now maybe they won't, I mean they could possibly still come, we don't know what the story is, from what I heard from DeadEyeDan last night is that he was playing with Trevor and Trevor mentioned how there will be one more patch to come before they finish for good and this patch I think he said is going to address the railings so that you would be able to shoot through the railings, apparently you can't do that now and this little fix that might have other fixes as well but that's the one that was mentioned to Dan and Dan told me so there could be other stuff in that update that might fix other things maybe the grenade thing you know we were told that options for using grenades were going to be added but this was a while ago back when you know first contact wasn't going to close down so who knows if that's ever going to happen the next question then is what's going to happen in terms of firewall ultra and the future of firewall ultra is it going to keep going is it going to be shut down will there be updates what's going to happen so few people have met this point and I think it's a good one I've seen this in the discords and what not that evolution studios who are owned by sony they shut down months before drive club v or even released so that game came out after the studio shut down and the servers for that were kept going for four years so that does give us a little bit of hope that maybe firewall ultra will be in a playable stage for years to come which would be grace hopefully boss what about content updates what about fixing things what about adding things we don't know will sony put like a skeleton crew will they give it to another studio to look after all the stuff is up in the air my hope is that sony put out some kind of an announcement a blog post or tweets or something where they kind of give us some kind of indication as what's going on with the development of firewall ultra uh but no one sony they'll just say nothing and we'll be kept in the dark and you know we won't know and I've said this a few times already some people are saying you know some people have a low opinion when it comes to first contact entertainment there's some places where you cannot say anything positive about firewall ultra or you will be shot on uh there are some people who are going to be happy to hear this news and that's fine if you don't like firewall off you don't like first contact for whatever reasons you have the reason I'm not going to convince you otherwise probably uh but I would just say maybe try to keep in mind the human element that there was dozens I don't know the exact number but I assume it's in the dozens of staff members there who are without a job now at Christmas time which is incredibly rough and first contact entertainment have been nothing but good to me and this channel for years now ever since hess gave me a shout out at E3 you know back before the game even launched which was like a highlight for me something I never forget and we've had a good relationship since you know we kept in touch uh he's given me codes for stuff like that and for giveaways and you know even recently judging the uh the video clip competitions and stuff like that so about a great relationship I've had nothing but good things to say about first contact entertainment that's not to say I agree with every decision they made with firewall ultra and whatnot and even firewall zero hour to some degrees as well but I still feel like it's uh it is a massive massive shame that we're losing first contact entertainment no other game is trying to do what they're doing I mean people will call us Pavlov and preachers that just came out as well too early to make a decision on how I feel about preachers or whatever boss I will tell you that there's nothing else that feels like firewall ultra in terms of the triple A level of polish you know when I'm playing firewall ultra I can see the money on the screen I can see the Sony backing behind us you know and the details the way the freaking the sparks fly up when I hit a certain metallic objects or something like that you're just not going to see these little things and of course people will be like well that's not important these are just visual things but I think it adds to us I think that adds to the quality of the game uh as a whole and it's like a big reason why I loved the original firewall and I think a big reason of why it did so well so while some people may be happy to hear this news I think if you're a viewer fan or especially a PS viewer fan in general that this is nothing but bad news because we're losing a triple A game Sony is pulling support away from us and that can't be good after four months four months with a live service game and how many times have we seen a game a live service game even launching in a poorer condition and taken the years to come good basically look at no man's sky how long it took them to turn things around look at battlefield look at rainbow six siege even that game was hasted for months and months and months before they turned it around and it became you know one of the hottest games of all time fortnite even just launches a weird survival game thing until they launched the battle royale mode and that changed everything for them so I'm 100% pissed off at Sony that uh listen I can understand from a business point of view if it's not making money it's not making money but four months is no amount of time to allow them to turn things around especially within those four months we're seeing signs of progress signs of improvement signs of getting firewall ultra to where it needed to be and they still pulled the plug anyway I think this is uh this is something that will have me worried now not just about firewall ultra but this the psvr2 in general and sony's attitude toward us so yeah I don't really know what else I can say about this uh it's incredibly sad news like this channel was practically built around firewall zero hour back when nobody else was covering us and I saw this game I saw this gameplay footage and I was like this is crazy this is exactly what we want on psvr1 nobody else was doing this but other people were turned off by bravo team you know they're like oh it's gonna be another bravo team even though clearly it was going to be nothing like a bravo team if you actually watched the footage so I started covering it and people started coming and watching because some people out there agreed with me you know some people saw that firewall zero hour was something special that first contact entertainment had managed to create something special which they did and I was able to grow just from that game really like most of you people watching this right now are probably here because of firewall and now that's going to be gone or at least first contact entertainment is going to be gone again I don't know the future of firewall maybe I'm going to be having more videos to make when it comes to firewall ultra obviously a patch is going to come and I'll be covering that to see what that improves but after that in 2024 will I ever make a news story about firewall ultra again other than to say oh sony had given us 12 months before they shut the servers or something like that I don't know so yeah it's really sad it is really really sad it's probably the saddest video I've ever had to make on the channel I hope I don't ever have to make a sad one like this again you know when a studio like first contact entertainment with talent that they have the proven success that they had with firewall zero hour they had 10 seasons of post launch support with that game and sony saw us and even back in 2020 there was a top 10 revenue generations for viewer specific games and firewall zero hour was 10 in that list and that was up there with half-life alex and all these other games that have been out for a while and big names you know no other ps fewer exclusive was on that list but firewall zero hour was there and despite all this despite that cache that you'd imagine that that would afford first contact entertainment sony are pulling the plug after four months and I think it's disgusting shame on sony in my opinion I know it didn't launch perfectly I feel like there definitely should have been a bazaar for firewall ultra and again does that land on sony's laps or lap I don't know but it certainly feels like something that sony should have been involved in especially you know they own the IP they're the ones who kind of make all the big decisions and I feel like a bazaar is definitely something sony should have been a part of and should have made happen or allowed to happen so maybe they want maybe first contact wanted us and sony didn't allow us I don't know I don't know the story I don't know if we'll ever know the story it would be cool to see if you know any of the previous first contact entertainment developers come out and actually go into more detail as to what went on behind the scenes there you know it'd be interesting so yeah that's all there is to say really first contact entertainment or no more firewall ultra the future of that game is in doubt I'm going to keep playing as it's going to be in rotation on this channel for as long as the servers stay up I will be putting this in rotation I'll be hoping to play it as much as I can because it is unmatched that game in terms of the core gameplay elements in terms of that mode the tension in that mode is just like it's just not matched the communication that you need is just no other game have I had that and I'm comparing flat games as well just nothing else has it anyway I'm going to end this video lads and ladies um before I do I better thank my channel members Dante Bruce mr. 777 aced lone wolf the ore edify till I die superfly af crumb Pete Hawkins deej the pumpkin patch kid move master make esports commentator for hire no one knows chopped PPE dead I dan and moz thank you very much for that support it is greatly appreciated and if you would like to become a channel member you can do so by clicking the join button and you will gain access to exclusive channel member perks that is all I have to say thank you for watching this video and first contact entertainment if you're watching this or any of the members at first contact entertainment I want to give you a special thanks for giving us something special you found success in a field that very few people can in a you know particularly a live service game it's really difficult to do that in virtual reality and I think you know hats off to every single one of you who was involved in that past present you know and I hope everybody lands on their feet I hope to see you all working in the game industry again hopefully specifically the viewer industry but you know wherever you gotta go you gotta go and I wish everyone involved a merry happy Christmas and a happy new year and to every single person watching as well happy new year happy Christmas I hope you had a good one it's after it's after Christmas but you know happy new year and I'll see you in the next one goodbye for now