Astrocytes act as a dynamic CL reservoir regulating CL homeostasis in the CNS. Astrocytic CL is high in stable during sleep, it is lower during wakefulness and fluctuates in response to sensory input and motor activity. F-lux of CL from astrocytes supports inhibitory transmission in the CNS. This article was authored by Verena Untayet, Felix Imbanelik, Peter Kosk, and others.