Well, we didn't time that out well, but we are live We'll see if the audio synced up like we always have to do but welcome to the live stream Adam does movies It's a Tuesday Tuesday night 10 30 8 p.m. A little behind not too bad before I really dive in I'd like to hear from Some people on the stream that we are in fact Synced up everything looks and sounds as as good as I can do it so I will just pour my coke and And to wait further instruction. I like to tap it a few times Audio is off Okay, this is why we do this. Oh, yeah, the sink off so The audio should be on now. I wanted to give it a little time little time to percolate But we should be good on the audio we're gonna be pouring a coke now Should sound crisp No, the problem is fixed David. We are good. We're good, right? We're good on the audio I can start this thing get the ball rolling. I'm coming up. I want the world to know and Still off oh, whoa, whoa, whoa, okay, okay Let's figure it out Sink offset is at two thousand Just slightly Let me hear it. Let me hear it for myself After this commercial break. I have to be able to visually see what's going on.   This is what we do.  It's right on. Oh my god. What is I don't even know it ladies and gentlemen It was at zero.   I noticed the camera is also doing this like weird matrix glitch out Not really something that I care that much about but I mean these are just the things folks that we deal with Don't fix it.  I didn't change a thing Matt Matthew You know Matthew was here he lives kind of by the area in South Carolina So he took a tour of the studio and he sees just it's a house of cards over here I have my can't I have my computer on one two three four five six seven eight like 12 foam cubes to get it where I need it to be My mic is teetering on the brink of falling I have another foam piece on top of this camera. That's keeping a glare out from the lens people People become patreons for Christ's sakes. Help me out.  It's embarrassing Genuinely embarrassing what's going on over here with this production over a decade on YouTube and we're still dealing with audio hiccups I'd say I would say it was charming if it wasn't so pathetic. Okay, let's get to it Yes, I am looking forward to know no hard feelings starring Jennifer Lawrence. That question was on the house If you want to ask me questions at the end, I would love it super chat a dollar or two dollars or $100 and say hey Adam. What's your favorite color? Adam what what's your favorite little? Ball that you get out of one of those quarter turn machines back in the day They haven't really I don't know if those exist anymore Adam. What's your favorite flavor jelly bean? These are some of the kind of questions or it could be movie related But yeah throw a super chat in and at the end of this I will look over them if through there I saw another glitch We're just nothing I can do It's nothing I can do What let's get into it. I have today The main topic for you the flash movie reviews are in from the professional critics that aren't me even though I am rotten tomato certified. I don't have access to early screeners. I go like everyone else I like to get out to a Thursday showing Typically, I try to go to an early afternoon one if I get my work done and I have time This week is not in the cards. I have surf lessons every single morning You'll notice the surfer hair and a little bit of the facial fry. I've been surfing folks First time ever I lived in Minnesota my whole life. So I didn't really have access to the ocean now It's carte blanche.  I couldn't get up on the board. I couldn't get it up as they say Today was much better. I actually was able to stand the g-forces were crushing down on me, but I was able to It's able to persevere and yeah, we got up five or six times. It was quite a sight to see Some people on the on the side of the beach were like, oh my god, this is remarkable I've never seen such grace such fluidity in a man of his stature I'm liking it. I'm liking surfing. It's not gonna be a hobby really It's gonna be this week and then I would like to get some boards for the kids Maybe dabble here and there, but I'm not gonna be going to the beach every other day to surf I do enjoy it though. It's something that I can add to my repertoire Put that in the utility belt and say that's on the bucket list. Now it's crossed off a lot of different Random metaphors there. Okay. Here's the topic for the day We're gonna be doing the flash movie reviews from professional critics that aren't me We're going to be talking about a game a movie game that came out and was gifted to me This is the bizarre part the people that made it reached out to me on tiktok when I had like 600 followers Not that I have a lot of followers there now at adam does movies, but You know, it was just kind of funny. They reached out. They're like, hey adam We're making a movie trivia game.  I'm gonna unbox this thing I'm gonna give you my honest opinions on the game on the box on everything about it And uh, we're gonna try our hand at it. I see it's three players or more If this goes well and it seems like a fun game Maybe on a future live stream. I bring in the family And we do some sort of a Let's play for you of this thing But I don't know this could be really bad It might not work as you can see. I already have a hard enough time just streaming myself I couldn't imagine setting it up for four of us. What a nightmare scenario that would be But you know, that's that's part of the charm of the show.  Let's begin. Hopefully I prepped this correctly. Uh, Sheila Was supposed to come in and do this ahead of time. Sheila, you know, my fictitious Co-worker who wants to know all I fire comes in and set stuff up for me But we'll see if Sheila set it up correctly So I need to hide this camera and oh there I am. I'm down below here Help me. Help me. I'm down here now I'm a real boy Here we are. We have flash on rotten tomatoes the site that everyone trusts more than anything else It's it's basically its word is that of Some sort of higher power We're looking at 73% right now folks with a tomato meter fresh at 70 reviews fresh as a daisy And I see super chats coming in I appreciate it. I have them banked I have them Tyra banked. We're gonna go back to them later. So thank you for for providing those Let's get down to it Let's get down to business Let's ride Let's ride Into the reviews We have pros and cons. We're gonna just take a smattering of all of it Kevin I'm not gonna read these names. Kevin Mauer will we'll give him one. He's a top critic. He says A morally specious movie that's mostly about reflogging the cultural canon of an entertainment conglomerate I didn't know what most of those words meant, but I think Kevin thinks this is bullshit. He doesn't like it Trace Savour Trace saver I don't know.  That's a cool. It's way cooler than me. This person's way more interesting than me It's a pitiful disservice to itself Turning a relatively fun if rocky movie into nothing But another product designed as a carousel where you can point at things and people you recognize Memba dat I memba I memba flash I memba michael keaton batman. I can see where trace might be coming from but at the same time Some people like that might be fun katie or kate Taking on its own merits andy Muschetti's film has lots to offer and frequently shows flashes apologies of brilliance that said He's doing a little pun and frequently shows flashes of brilliance that set it a cut above most of its existing dc universe brethren It's a flash in the pan is what she's getting at Wow Let's go fast to christian hullab.  I didn't like that at all hmm Interesting keep in mind. This is a rodin's score, but you look he actually gave it a c-plus He actually gave it a c-plus and that's a rodin. I guess in his work in his world Alonzo says Maybe nerd culture Was a mistake Okay, so some of these people are just not doing this mathy jackson from the av club It's sometimes buried under layers and layers of storytelling knots that the film never fully untangles But the fun is there and when the film is really working That turns out to be enough People probably know some of these guys and my voices have to be completely wrong, but we're having fun James marsh actually know a brother-in-law named joe marsh interesting names spelled a little differently And uh fully victim to its own thematic mantra the flash refuses to let go of the past Instead allowed it to define what it has become in the present. In other words a hodgepodge A former glories with no identity of its own that was a hodgepodge of nothing james john Flash is a fun and adventurous film that brings a lot of nostalgia and dc goodness into the fold And michael keaton as batman is definitely the highlight of the film germane Let's go country with this guy for no reason at all The flash is a satisfying superhero experience complete with epic scale heartfelt emotion a back door origin story and a few issues along the way Okay Brian says with the flash bungles and franchise reconstruction and formal execution. It goes right in fans service and momentary pleasure Sounds good mark positive review here the first feature film Featuring the subatomically fast dc comics hero is a zippy and entertaining blast And yet it nonetheless manages to serve up a few heartfelt moments amid all of its carefully choreographed chaos Mark Just one note. I don't like that. You started with the first feature film featuring You put feature and featuring Just a word away The first Feature film featuring is ugly. Don't say that You could have just said the first film featuring what why even add the feature in there at all. It's a poor feature the first feature film Containing including Showcase scene And These are all things you could have used instead of featuring Don says For as much as all the talk of the pretending fate leads to dashing heroics and the extravagant the flash One can slow their roll step back and see plenty of the hot mess and crapshoot Michael Keaton's batman was talking about in character Is this one sentence For as much as all the talk of pretending fate leads to dashing heroics in the extravagant The flash This is what is this one sentence.  This is terrible We got more we got more critics here. Let's see what else we have We we we got a we should we should have actually started here because now it's a this is a hodgepodge and amalgamation of good and bad reviews Here we go. Peter As another comic book offering hop hoping I always say hopping as another comic book offering I'll get so confused As another comic book offering hoping to leap around any fatigue audiences may be experiencing from a relative over saturation It's back to the future inspired mentality places it on a higher plane than many of its fellow dceu counterparts four out of five from peter the gray Charles says While the core conceit of water brothers discoveries the flash is solid the movie's too meta nostalgia plays highlight Everything that has gone awry with the studio's superhero movie experiment Let me do it. Let me try and obama All the sins and triumphs of dc's past cinematic aspirations have been laid bare in a grand parade Uh, one of the most watchable dc films in the last decade merely by standing on the shoulders of everything that's come before Not bad from kevin Danielle the flash resets the universe in spectacular fashion ladies She didn't say ladies. I threw the ladies in there Nick says considering how the flash makes many of its characters face death and inevitability throughout the flash Should not feel as hollow as it does Travis from punch drunk critic says P好了 Predictably disjointed and messy coming out of such a problematic production But it's not enough to slow down the genuine love for the character luke says If not for all the baggage, there is a real chance miller's performances here could have been in the awards conversation Wow luke really really liking it But Carla says it's bold, creative, and with some appealing quirks, The Flash lives up to expectations and offers some jaw-dropping surprises. Viewers who are new to the DC Extended Universe, DCEU, won't get too confused while art and fans will constantly thrilled. Kevin says a morally spacious movie that's mostly about reflogging the cultural canon of an entertainment conglomerate. I think I already read Kevin.  He did it. He did it. All right, I think that's enough. So this is what sets Flash, oh what, we can't do that, keep that over here. That's what puts Flash at, oh it's down, I think it's 73 now, did it go down one or let me refresh? 72, it is dropping. It's dropping, I can't think of an analogy that would work for this. It's dropping guys, this is why I write stuff down. Okay 72% of the Flash, you heard it here, the good, the bad, the flashy. We'll see if it, we'll see if it's good, come this, wait when does this come out? It's a Flash release date, it comes out in a couple weeks. This week is Transformers, give me out of this, give me back to my regular camera. Okay, I'm like purplish today for some reason. Let me go back and read some of the super chats since I don't know if people can stay till the end. So we have Internet Guy, you see Sisu yet or Sisu, I never know how to say it, Sisu, Sisi. So while I have not Internet Guy, is it available anywhere? Because it wasn't in the theater at the Regal Cinema and it's the only thing I have access to is Regal here, so screw Regal, I'm going home. But if it comes home to stream, then I will absolutely watch it because I have wanted to watch that since I saw the trailer. Ed Boy Movies, I've been so out of touch with a $5 super chat, thank you. I've been so out of touch with Movie Video Games the last like decade, but that's still a thing. Movie Video Games, yeah that's a thing. Actually Movies based on games are getting good now, that's the surprising part. Not great. I mean the Mario, I thought the Mario movie was about as solid as I could have hoped for. I know, I know that guy kind of raked over the coals by the expert critics, but I thought it was a very fun, fancy free hour and a half fly by movie about a, you know, an overweight plumber who saves a princess from a giant turtle. The plot kind of seals itself. Internet guy with a powerful $5 super chat, followed you since your days in Delano. Glad you here, you escaped Minnesota, I did as well, down in Florida now. No regrets. Looking forward to the flash to be honest. I'm looking forward to the flash too, I think it looks solid. I really do and I don't care for Ezra Miller as an actor, I think he kind of sucks.  I'm glad you're enjoying Florida, I am enjoying South Carolina, I really like the weather. I am missing the infrastructure of Minnesota, the cleanliness of Minnesota. Pretty much I'm missing everything about Minnesota except for the weather.   Jan Rose in the mix, chatted with her a little bit earlier on Instagram, I believe, or Facebook, it's kind of the same thing. They kind of blended everything together.  Thank you for doing these awesome lives. They make our nights better. Appreciate all you do. Well, I appreciate people even watching these live. It's actually awesome. I look forward to doing them as well. Even though I get very nervous doing these and this is not my Will Forte. I like pre-shooting stuff, being able to edit stuff, being able to write down some jokes here and there.  And obviously the audio gets up. The colors aren't exactly where I want them. The picture quality is not where I want it, but we're starting. You know, we're doing it. You got to put yourself out there sometimes and try new things and I mean, to be honest, like I've been doing this show for 11 years now or 12 years now. It starts to get stagnant. So it's nice to switch things up with the podcast, with these live streams. And I'm having the most fun doing these now. So yeah, they're not going to stop anytime soon as long as people tune in either during the live or after. There is a live tab. Some people don't even know it exists where you can watch all the past episodes. Okay. Let's go to the second thing, which I'm kind of excited to try out. I genuinely don't know. We have a game that was given to me, as I said earlier, and that's it. Movies, made up movies is what it's called. This is the thing right here. Let's really give this a professional breakdown. So it's called made up movies. This is not a sponsored video. They didn't ask me to do anything. Maybe when this is all said and done, they would have wished they didn't ask me to do anything. But we'll see how this goes. First impression. Let's try to get this out of the glare. This could be a box for anything made up hookers, made up bedtime stories, made up, you know, kitchen utensils. There's nothing on this box that says movies to me. Where's the popcorn? Where's a standard cinema reel?  Not matinee. What's the word I'm looking for? Marquis. The Marquis. Nothing. So this is really just kind of very generic. The other thing I'll point out is I don't like that there's more, I mean this is a printing issue probably, but I don't like that there's more padding on this side, more space over here than there is over here. I like this logo to be centered if possible. We're talking really nitpicky. You can see my smashed up finger right now. The deformed thing. I actually have two injuries, folks. So this one, the middle finger, which is perfect. Yeah, look how gross that is. That's a lifelong injury right there. I've pointed this out before, but since we're getting all up and close and personal, look at this. Look at my hands. Oopsie. This one's a little bit taller. I wish I was a little bit taller. Wish I was a baller. What happened was when I was six or seven, I pulled on a dock plate, which is a metal ramp that semi-trucks drive up, they kind of back into. And I was trying to do like an Indiana Jones. In my dad's warehouse, he was doing some paperwork or on a phone call or doing blow in the back. I don't know what he was doing. I don't know what 30-year-olds did back in that day. Hey, she was probably in his 20s. She was very young. Anyway, me and my brother were out there. I pulled on the chain thinking I was like Indiana. Duh-duh-duh-duh. Scared to death. The thing starts to lean down on me. Like the Tower of Pisa has been detonated. Like the two towers are collapsing and I'm running. And now I really am living out an Indiana Jones experience because the Boulder, aka the dock plate, is barreling down on me.  This thing is dropping like it's hot. It slams on to my middle finger, which is sticking out. Thankfully these prongs that make the ramp held me underneath of it. Like it went right above me. This could have been death. Straight up dead. Really lost the tippy top of the finger. Got rushed to the hospital.  I don't know what it is.  But yeah, she's not quite the same as she was when I was six. This one, which looks like I just painted it like I'm a goth kid, that I did a few months back. I was doing some yard work and I had one of these giant pots with dead plants in it because my wife never takes care of anything. And I tried to lift it into the garbage can and I slammed it down and my pinky was on the side and yeah, the pots smashed right into it. It's just a gorgeous, gorgeous purple. Really sets the tone for a 40-year-old dad. So a couple of injuries. I expect I'll have one surfing in the next day or two as well. I'll probably hit my head on a rock or a shark.  We'll leap out. I'll have to punch it. Welcome to Earth. Probably won't happen. Okay, let's focus. Let's forward focus. We have this game. We're going to unbox it. Now, I already noticed there's really tight, oh, we didn't, we didn't talk about the back of it yet. So not thrilled with what I'm looking at here as far as the visual representation, short for representation. This is why people don't send me stuff normally. The back of the box, let's try to get that glare out. Not very exciting either. Something you would see on a standard square space site. It's not terrible, but it's really not doing anything for me. All right, let's open this up. And I see that we have the tightest plastic imaginable, oh, I got, I got a side. Okay, very nice. Just a little extra pageantry. No, it didn't really happen. Okay. Picture like steam coming out. Watching MTV. We have a little booklet. I assume this is instructions. I'm just going to set this, oh my God, stuff's flying out. Universal pitch template, meetup movies.  You know, it's a drink you would get at a movie gives you a little bit of the flavor of that. Like I was thinking things through. Okay. Here's the instructions. Let's set this over here. Meetup movies, the party game of ridiculous reboots. I like where this is going actually. It's a trifold. It's your standard classic trifold. How to play. I might need my readers on and they're not here. They're upstairs. Maybe I'll bring up the phone and magnify this.   Win over the other studio executives and get the biggest budget by making everything up as you go. Players take turns pitching while other players play a studio executives. Oh, interesting. Okay. Take turns pitching while other players play a studio executive. So maybe you guys can be the studio execs. Reboot pitch. The player pitching, okay. The player pitching lays out pitch cards in the order shown on the universal pitch template. Movie, star, star, genre, setting, movie, movie.  Let's let's look at the let's look at the box. Let's go to the box. We have a tell me, oh, executive studio, studio exec. We got elaborate. We got star. That's what I was looking for. Star, movie, setting, genre. Okay. So it goes movie, star, star, I only have one star. I only have one star. I don't know about these directions guys. Okay. We're going to open these. There must be more inside. Oh God, it's going to be the tightest plastic imaginable. Do I have something sharp in here? Okay. We have budget for some reason mixed in with the star cards.  There were nights when the wind was so cold. There were days when the, would you touch me like this? Would you hold me like that? It was so long ago, but it's all coming back to me. God open. Okay. We got it. Movie, star, star, genre, setting, movie, movie. Really complicated. Bra, setting, movie, movie, I'm getting better at opening them, setting, movie, movie. I assume I can just kind of take from one of the other card piles. Okay. That was a lot. Oh, we got to put one more pile over here or just bring these apart. We're going to do like one round of this. Okay. Begin the pitch by turning over the one minute timer, then flip each pitch card over from left to right. One at a time reading each card allowed while filling in the universal pitch template sentence. Finally make up a title for the reboot before the timer runs out. Okay. This is the template. So it's like, this is a reboot of movie title, starring actor and actor. It's genre, set, then the setting, think, movie, meets, movie, and it's called blank. All right. This is actually kind of cool. Finally make up the title of the reboot before the timer runs out. Okay. Then the studio executive questions. Each executive will read aloud one of their three studio executive prompt cards from the hand. If playing with three players, each studio executive reads two questions. Okay. The player pitching will have one minute per executive to respond. Distributing budget cards. Once all pitches are complete, each player uses their budget cards to rank the reboots. Do not vote for your own. The player with the biggest budget wins. Game set up shuffle pitch cards and place them four separate stacks on the table. Little studio executive cards, place them on the table, draw three for each player, draw budget cards, one to five million for each player. Each player should have one less number of budget cards than the total number of players.  Official rules, three to six players, 45 minutes in length. This will get you through some rainy days. The player pitching must stand up and draw cards from the pitch card stack on the table, pitching them face down, or placing them face down in the order shown on the universal pitch template. Do not flip cards over yet. The studio executive to the left of the player pitching will turn over the one minute timer. Using the universal pitch template card, the player pitching must read each card aloud as they flip them one at a time. Every player must use the same universal pitch template. Okay. After flipping all the cards, the player must then make up a title for the reboot. Yeah, I think I get this. Okay. We're going to try it. Let's flip the camera. Having a movie card, star card, star card, genre, setting, movie, we have an elaborate card. I'll get that in a second. This is a studio exec card, the timer, and we begin. I'm going to do my Jonathan Cross movie exec voice. This is a reboot of Willy Wonka and the Chocolate Factory. The film stars Jason Momoa and Gal Gadot. It's a giant monster movie set in a corporate office. Think Mean Girls Meets Dumb and Dumber. This is a reboot of Willy Wonka and the Chocolate Factory starring Jason Momoa and Gal Gadot. It's a giant monster movie set in a corporate office. Think Dumb and Dumber Meets Mean Girls. Listen, and I got one minute to pitch this. Oh wait, I think I got one minute to pitch now. Hourglass is going. Listen, we all know the chemistry share between Jason Momoa and Gal Gadot. It was all on display in Zack Snyder's Mastercraft Justice League. Snyder Cut. What we're going to do is we're going to put these two in a perilous situation inside of an office building. It's going to be very funny. Michael Scott, the office style, dry humor, top shelf actors, top shelf writing. But uh-oh, there's a twist. The office is actually a front for our candy shop. They're going to bring you here. This is set in the Willy Wonka universe and something has gone amiss with the candy creation. It has formed a giant chocolate rabbit that's going to terrorize downtown L.A., where the office is set in. It's up to Gal Gadot and Jason Momoa's character to keep this thing contained before it runs loose. I'm sorry, I'm so excited. And cause this havoc across the country. The film is called, tentatively titled, Willy Wonka.  The movie is called Willy Wonka X, Charlie and the Chocolate Factory. All right, let's do one more. Let's do one more. I can see how this is. Oh, I'm supposed to ask. So then the studio executive says, tell me why Jason Momoa has great chemistry with Gal Gadot. Well, that's simple, neither of them can act. So they channel their lack of skill with their overconfidence in charm. They match each other perfectly. They're both good looking A-list stars. They have the swagger. They have the moose like Jagger. And their lack of acting skill is going to be carried through this film because it's a comedy. And we all know when it's a giant caju monster movie, you don't need good actors. You need good looking actors. In the accent of an angry pirate, oh, I miss, I'm sorry. So there's little twists to these questions. It says, tell me why the stars have great chemistry in the accent of an angry pirate. Well, I'm doing Jonathan Cross, so I don't need to answer that. All right, one more. Let's do one more. Okay. This is a reboot of National Treasure, Nicholas Cage, starring Al Pacino and Selena Gomez It's a brutal war film set on the main streets of Chicago. Think Crazy Rich Asians meets wedding crashers. That seems about right. Of course, a spelunking treasure type film set in the same vein as Crazy Rich Asians and Wedding Crashers. I mean, the movie basically writes itself, look, we've all been, we've all been clamoring for a National Treasure reboot. Cage is getting a little older, maybe doesn't quite have the charm he used to have. But you know who does? Someone who's even older than Nicholas Cage, who's been around the block and back. And that's of course, who else, Al Pacino. But we got to have some young blood in the mix. Someone who also knows not only how to cook up great chemistry, but also her own food on Max, which used to be called HBO Max. And that's Selena Gomez. Al Pacino and Selena Gomez are going to be the new National Treasure hunters, hunter and huntress, working together side by side. This movie takes place in brutal war torn London. After a terrorist attack hits, some of the treasures that were lost and forgotten have been unearthed, waiting to be found. The clues are in place. The time is set and it's of the essence because they're going to be hunted throughout this film. However, however, because this is a little crazier, it's a little richer and it's a little more Asian, there's going to be some settings taking place in the mean streets of old timey Chicago. So it's going to be fun, it's going to be quirky, it's going to be irreverent. And Al Pacino and Selena Gomez are going to be on a globetrotting adventure. Going from Chicago to London and into our hearts. This is a movie you're not going to want to miss. We have a picture, I believe. Yeah, I'm pretty sure we have a picture here. And I think I covered all of my bases. Let's ask one question about this film. Describe the villain in the movie. Timothy Oliphant is a handsome collector of artifacts and timeless treasures, which I guess an artifact would fall under. He and Pacino have a history together. It's more of a herstory because it's a woman they both happen to love, Selena Gomez. And I know what you're thinking, Gomez and Pacino, not the closest in age. Well, Al Pacino is about to be a father in real life and his wife or girlfriend, I'm not even sure if they're married, about the same age as Selena Gomez. So this is very plausible, folks. In fact, he's living it. He's living it. Timothy Oliphant is a recluse. He keeps to himself, but he's got a lot of money and he's got a lot of patience. And he has a lot of technology, going to be a lot of drone play. He's going to be hiring a lot of mercenaries to go after these two or constantly on the run. You're going to love this movie. You're going to love Timothy Oliphant, who's really stepping into his own in this picture. Think diehard four times a thousand. And the title of this movie is, of course, National Treasure, Reborn. Reborn. Well, I think we knocked him out of the park. I don't know about you. I'm not sure which movie you like better, but we had Willy Wonka, X. Charlie and the Chocolate Factory, and we had National Treasure Reborn. This is actually a pretty fun game. If you have a bunch of movie buddies, I can see having a blast with this. It's going to be tough, though. Like my family, I don't see it working for. You really have to be, I think it even says 17 and up somewhere in this thing. Age is 17 and up. I'm not entirely sure why they put an age at 17.  So yeah, I can see this really has to, you really have to find a good tight knit group of people that you can play this thing with. But I do think it would be a lot of fun. I moved away from all my friends and family.  All right, well, there's the game made up movies. I would, I would absolutely recommend this if you fall in the category of having a couple of good buddies that you could play this with that know a lot about movies. This is definitely a very curated specific game for movie buffs. Everyone else is going to be completely in the dark. My mom wouldn't be able to play this. My grandparents won't be able to play this. Like it's legitimately people that live and breathe movies and that's cool. It's great that there's such a catered type of game for those folks. Definitely fans of movies made this game and it's cool. They reached out to me. I appreciate it. My review of this game out of 10. I would probably say for lovers of movies, 8 out of 10. You could have gone a little bit deeper, a little bit further if we would have had a little bit more movie theme behind it as it stands. This is anything like speech bubbles. Why speech bubbles? Give me something more cinematic. Give me a silhouette of a famous actor. You know, give me, there's just a lot of ways they could have done this. This to me could have been branded for anything. And so branding is a really big sticking point for me. I want to, I want to open this and feel like I'm playing something that has been tailor made for the movie fan. And this looks like cards against humanity re-skinned. Okay, super chats, any, any further. We read some earlier. It was powerful. It was beautiful. I loved it. I loved every minute of it. We, you know, I played a full game for your pleasure or displeasure depending. I think a lot of people probably dipped out once the game started, they're like, oh yeah, we're done. Oh God. Uh, isn't your strong female lead shirt in a speech bubble? I don't know. Why don't you tell me, why don't you tell me strong female lead. Yeah, but you see the ghostbusters, the female ghostbusters are actually the ones saying it. Someone's actually speaking and we know it's a movie because they're the female ghostbusters. Skiddy-dee-dee-dee, skid-ba-ba-ba-ba-ba. Okay, while I clean this up, feel free to throw a super chat at me.  I already have the beach hair, but I don't have my sea legs yet. Let me go to the game cam. It's all coming back, it's all coming back to me now. There were moments so gone and there were flashes of light. There was things I never did again and never did the dance, skid-ba-da-da-dee. Love and I- I don't know what, I want a Celine Dion kick. We had it playing earlier, not even that song, that's the weird thing. It was a completely different song, but man, Celine Dion. She can get it. Okay, what is freaking crazy? The cleanup on this game also is not great. I'm done, I'm done. Okay, we are cleaned up, we're ready to go, we're ready to shut this down. Pipple style. I am going to... What was I going to say?  I have to film some stuff. I have a review coming, not a review, I have a video coming out tomorrow announcing the glorious return of the guy I just pointed out, Khaleesi Grimes 82. He's going to be Patreon exclusive. There's a video coming out, his glorious return this month. It's at the $10 tier for Patreon and YouTube Join members. The cringe could not be contained until now. Pay him to the $10 Gold membership level on YouTube Join and Patreon. Every month a new cringe episode. Nerd alert.  Any other things worth noting? I have that Zulu review I'm doing, I have a Tucker and Dale vs. Evil review or whatever that movie is called. Those are both movie requests. The Transformers will be Friday and then the live stream Friday night and then the podcast Monday. There's always three things coming out every week and then I try to put other movie reviews out in between. Just a little behind because of work and because of surf lessons. So Kawabunga. Yes, of course. Bubba is right to point out. The Water Wars Collection. All four of my homemade movies in all their epic greatness are available right now on Patreon and at YouTube on the Join button for $10. You can become a member for one month. Watch all those films in their entirety. They're about 45 minutes each. Soak in, pun, because they're water based movies. All the greatness and say, wow, Adam, what a fall from grace you took. You were at your peak in late high school, early college with these movies. You were really on track to do something spectacular and look at you now. You can barely run a stream without having the audio off. You can't even play a game by yourself.  But yeah, so there's that. All right, I'm going to shut it down. Thank you guys very much for watching. Sorry about the issues, but that's just really, that's part of it. That's baked into the show now. I'm going to let you go. Thank you very much.


I'm Corbin I'm Rick and you follow us on Instagram Twitter for more juicy content put them together in this joke Twitter app And we're twit grab cool a ramster Instastir today we're reacting to a trailer a coffee additive of Cajun a par high This is Rithik Roshan's debut film Baby Rithik It's Rithik's birthday today. Happy birthday to you But I think we reacted to a song from this Remember we recently Like in the past couple of months two months ago, maybe but where he's baby face Yeah, he's baby face and we're like, oh like if you saw him right then like it wasn't as impressive because we've seen Older Rithik right and they didn't let him they didn't know what he could do right and But it was like real old-looking. It was like a really pop. I remember this and that's why he became really popular This is the trailer for that film got it And it's subbed by one of our suburbs. Yes, awesome Rithik's debut film Which is translated to tell me its love was the most successful Bollywood film of 2000 becoming the highest grosser of the year. Well, that's good for a debut. It's gross good grief It was added to the Limca Book of Records Limca We only know of Guinness. Wow, I love Guinness Limca Book of Records for the greatest number of awards won by a Bollywood film 102 Wow Following the release of this film Rithik became an overnight superstar His successful debut was termed Rithik mania by the media Wow, and it came out and what year did it say? 2000 Wow, I thought Rithik had to have been around way longer than that 102 awards. That's a lot of awards And I don't know what like obviously they're not all Like an Oscar or something like that. It could be like it could have won a kid's choice award or something like that I don't know uh, so you can start from third grade teachers exactly Uh, and from the summer they said they've watched this movie so many times It's fun to watch Uh, the entire soundtrack is great Uh, if you watch this film you understand why he became a huge sensation written and directed by rockish russian his father His father's one that got him into yeah mark the debut of his son It's like you when you make a film and start mica double role Who Rithik? Oh does he play double role? I think I just said he's playing two two roles. Well, let's see. Here we go But why do you want to put your life in danger for me? Because I love you Old trailers are so That's the song Remember? Yes, I do remember with that shirt and the nipple shirt Old trailers make you appreciate how much of an art form it is to make trailer set I feel like I just watched a film that was so freaking weird Yeah, and I think I liked how weird it was. Well, it was definitely had everything It was definitely old 90s bollywood it and it had no There was like no rhyme or reason to it at all. Yeah, it was just like the trailer. We're not saying the film Yeah, no no no this the trailer It's almost like somebody went into the film blind and just chopped up segments of it and Tape them all together. I think that's what it was because obviously since it's an old trailer 2000s old for Indian trailers. You can't find a lot of old trailers You want to hear something crazy right now? I'm betting somebody Displaced it's gonna freak you out. You're ready for this In five years Something from the year 2000 will be a quarter of a century old Technically right now. We are closer to the year 2050 than the year 1990 That's weird. It is. Anyway, you know what else is happening? What? You're Um, so yeah the this I felt like I honestly watched Watched a film because I think it was like a fan made this trailer. I don't think this is an official trip I felt like I went on some kind of an asset trip Yeah, it's it. I liked it. It's just because all the quick cuts. I know it's like you're doing I love you They're up on top of a mountain. Exactly. They're on the beach. They're on the mountains. They're on a boat. They're in the city Oh, man, it's how real people do things. Hey, I bet you the movie's not boring I bet it's not that it's just a non-stop fun fest. It's the reason we have Rhythmic motion and the reason I have is underwear. It's true right now I uh how many Stars that we know of Were overnight sensations Did that happen to uh, I feel like here with his debut It did didn't it because I remember when we talked about his life and I feel like you watch that video about him I feel like it used to happen more Right, but it seems obviously there was a like I think this was about as big as a Breakthrough debut as anything. Yeah, it was worth it. Yeah Um, I think people just found pretty well. It's understandable. The guy's he's a beautiful dancer You could already see though.  He's just a very attractive man um, and and of Obviously from the beginning as well. He was a good actor. So um amazing to That was I want to see if the movie's anything like the trailer I got to be in the right headspace for it and I'm in that right headspace right now I would love to watch that thing I'd have to hear it from the horse's mouth Because it sometimes was especially That time in in bollywood The melodramatic miss comes out sometimes. Oh, yeah, which uh, I don't like But not all the time because you know, uh, don't try to hide was during that time. Hey, do we have this? No I don't think I honestly I don't think we have any arithmetic That's a shame And I see here we will run here. I would bet half of our dvd collection is big b. Yeah. Yeah. Yeah, I'm gonna talk about As it should be it's true. Uh Go and read it for me a young girl meets the doppelganger of her deceased boyfriend That's the double role. There you go. And now has a chance to find the people who have murdered you With the doppelganger and they said it's a drama romantic thriller A drum thrill It's three hours long. Yes It's all bollywoods. Of course. It's three. I'm wrong thrill A drum wrong thrill and rom-rom thrill. Wow. How how big was Excuse me. Rithik Rithik Roshan's father about five five five six.  Your guess is as good as mine as a director. No idea. Um, because He directed it produced it composed it So you he did a lot I'm wondering anybody else in there. We've seemed to all I'm sure there may be some people we've seen sure Don't know there. Well, there you go. Let us know. Let us know the beginning of rithik mania Happy birthday, mr. Roshan. Happy birthday. Did we figure out how old he was? 40 45 Was he part of that? No No How old is what do you think? 44.


And a key to most successful people that I know in my age is they always sought out somebody that knew a little bit more about them than a particular area. Let's say I want to go into the software business and I've dabbled in it before. Let me go find somebody that's actually started a software company and got successful to it. Been with it. This guy's got a trucking company. Let me go talk to him about what that's like. This guy was a real estate investor. Let me go talk to him.  They've been down the road a little bit more. And if you ask somebody who is successful, they'll say, man, how did you make all your money? And inevitably they'll say, you mean the first time or the second time? Because everybody who achieves some success generally loses their first fortune. They may lose it to a family economy, a corrupt business partner. A lot of guys I know have lost their business to their ex-wife, their spouse. There's no women in the room so I can use the male gender for everything. So you can't be lazy. You always got to be seeking out new people, seek out new friendships. You see somebody who's sharp, man, I like to hang out with that guy, invite him. Be the one who initiates. I know that if I want to hang out with people, my guys, my buddies, I'm like, hey, what's everybody doing tonight? Let's get together. Let's do this.   With women, don't text them. But if you have friends, be the one who initiates. Be the social ringleader. Be the one who puts people together. Be the guy that, hey, I'm bringing this group of people together. And you'll become the social leader on that. That translates into every air of your life. If you're able to do that socially, then you'll be surprised how well that translates into bringing people together in a business sense. You want to bring some investors together. I've been doing this in my social life all along. I've been initiating this, bringing guys together. I've learned how to invite a bunch of people to a happy hour and sit down and have a conversation with them. I've learned how to work the room. Guess what? You get a business idea. You want to get into business. That skill translates right in to being able to, hey, I can bring a group of investors together. I can talk to these guys. I know how to relate to them. I can talk to them because all business is done on a friendship level. You've got to have a good idea. But the trust for somebody to hand over the money or somebody to say, hey, I'm going to come alongside of you. Let's go make money. Let's be successful doing this. It's going to come back to their ability to trust you or they feel connected to you in a social and a friendship level. So you want to seek out wise mentors.


Additional cast members, a teaser trailer, and a release date has now been confirmed for the new season of Netflix's The Crown. Join me today as we look at what to expect in the fourth season, and final season with this cast might I add. Ladies and gentlemen, this is Matt Rodgers. A ton of the comments in my other videos covering The Crown show that a lot of people are holding out for Princess Diana to make an appearance in the hit show. Well, wait no more as we now know who will be taking on the role. And they made Diana a poignant part of the teaser as you see here. But before I get into that, I'll tell you who I've always thought would be a great actress to play Diana, Jolly Richardson. Remember the actress from 101 Dalmatians? She's obviously a bit too old now, but in the 90s they could have made her identical, plus she has the added bonus of being British. Just a thought, but obviously to accurately portray the Princess of Wales, they needed someone younger, and they found her in actress Emma Corrin. Now Corrin has a pretty thin acting portfolio, with not many credits to her name. She was most recently seen in the movie Misbehaviour and DC's Pennyworth, but really nothing entirely notable up to now. She definitely looks the part, and the casting directors on the show have always picked great actors previously, so I trust their judgement. I was confused at first because the producers of The Crown released an announcement saying that Diana would be played by actress Elizabeth Debicki. However, they have confirmed that this is for the final two seasons, five and six. So, looks like Corrin is just getting a short go at playing Lady Di. Debicki had this to say about joining the cast. Quote, Princess Diana's spirit, her words, and her actions live in the hearts of so many. It is my true privilege and honour to be joining this masterful series, which has had me absolutely hooked from episode one, end quote. Debicki has a bit more of a fleshed out repertoire, with credits like The Great Gatsby and Guardians of the Galaxy 2, and even Christopher Nolan's new blockbuster, Tenet. But something that both actresses playing Lady Di have to strive towards is sounding like the princess. Vocal work and dialects is obviously something The Crown concentrates a lot on, but it had me thinking. As world famous as Diana is, you very rarely hear her actually talking on camera. It made me realise that I don't even really recall how she talks. Watching an interview with BBC, I realised that she has a beautifully eloquent speaking voice, which I'm looking forward to seeing emulated in the show. Take a listen. I think every strong woman in history has had to walk down a similar path, and I think it's the strength that causes the confusion and the fear. Why is she strong? Where does she get it from? Where is she taking it? Where is she going to use it? So we know that Diana will be around until season six, but I'd say this season we're probably just going to get a taste of her introduction to the royal family and the wedding, but not much more. It will surely be riveting though to see her story played out over the coming seasons. But apart from Diana, what will this season really be about? Will we know Margaret Thatcher will be front and centre, so we can expect some back and forth due to the complicated relationship between Queen Elizabeth II and the formidable Prime Minister, who will be played by the marvellous Julian Anderson, known for the ex-files and more recently sex education? Anderson had this to say about the role. Quote, I am so excited to be joining the cast and crew of The Crown and to have the opportunity to portray such a complicated and controversial woman. Thatcher was undoubtedly formidable, but I'm relishing exploring beneath the surface, and dare I say falling in love with the icon who, whether loved or despised, defined an era, end quote. I for one am so excited to see these two powerhouse characters and actresses go head to head as their relationship was a constant power struggle. My previous video confirmed that Imelda Staunton will be donning The Crown after season four, which is very exciting, but we now know who will be her Philip. Jonathan Price will officially be the third actor to play Philip in the show, and you may remember him from shows such as The Two Popes and Game of Thrones. He joined Imelda in sharing his excitement, saying, Quote, I am delighted to be working with Netflix again. The positive experience I had making The Two Popes has given me the confidence to tackle the daunting prospect of portraying Prince Philip. To be doing so with Peter Morgan and the company of Imelda and Leslie will be a joy, end quote. Peter Morgan of course being the show's creator and Leslie being Leslie Manville, who's being confirmed to play Princess Margaret. Unfortunately, I have a feeling we're going to have to wait a while to actually see the new cast take their places. However, thank God we don't have to wait as long for season four like we did with season three. To avoid such a long hiatus, Netflix filmed season three and four back to back, which was lucky considering the state of the world right now. The release date for season four is set for November 15. But what are you most looking forward to this season? The royal wedding? The intense dialogue between some of the world's most powerful women? I'd love to hear what you think, so let me know. I'll be down there in the comments. But be sure to subscribe for weekly videos covering your favourite movies and TV shows. If you subscribe during this video, then walk them aboard. And if you had a good time hanging out, then spank that like button. This is Matt Rodgers, and that is all.


Well, good morning, everyone. I'm Eric Green, Director of the National Human Genome Research Institute, and I'm delighted to welcome all of you to this day-long special symposium entitled Genomics Landscape a Decade After the Human Genome Project. Thank you very much for coming, and I can guarantee you we have a very special event in store for all of you as the day progresses. Let me immediately point out to you that it is DNA day. April 25th, which is DNA day as celebrated every year. Now it's a particularly special DNA day, and of course the origins of DNA day relate to the fact that indeed it's held each year to commemorate this remarkable discovery of Watson and Crick, the double helical structure of DNA and this famous publication in nature. It is worth pointing out that today of all days is the 60th anniversary of this remarkable publication, which is the reason why we chose to have this symposium today as we're having. But in fact, a lot has happened in the past 60 years, and in fact one of the most monumental things that's happened in the last 60 years that particularly relates to this remarkable discovery about DNA was the Human Genome Project, which took place from 1990 to 2003. And the thing we're really celebrating today and commemorating today was the completion of the Human Genome Project. And that completion was announced in this press release, actually it was announced from this podium and associated with this press release precisely 10 years and 11 days ago where the international consortium involved in sequencing the Human Genome and carrying out the goals of the Human Genome Project declared the goals complete and the project is over. So that's really why we are here. We are here today to celebrate, commemorate this remarkable achievement that was wrapped up 10 years ago. And in fact shown here are some banners that especially the NIHers in the audience might have seen on some of the light poles around campus have been up for a couple of months and will remain up for a number of months. So what I thought I would do to open this symposium is really to help reflect back on what all of this really means and to think about how much the world has changed. And describing to you some of this, I really want to frame it around essentially a 23-year interval, if you will, with three major punctuation marks, if you will. Looking back on the year 1990 when we began the Human Genome Project, I can vividly remember it. I was a participant from day one on the front line and it was a remarkable endeavor to be a part of. I can also vividly remember the year 2003 where announced here at this podium the completion of the Human Genome Project and there was great celebration and great fanfare. And when we find ourself now in 2013 celebrating this completion of the first decade having now in hand the sequence of the Human Genome for a full 10 years. Well, these are three time intervals, if you will, to think about and the world really has changed if you think about, you know, we've changed U.S. presidents, we've gone from Bush 1 to Bush 2, and now we have Obama. We've changed the way we listen to music. Back then we tended to listen on cassette tapes, but then by 2003 we were using Discman and we were using CDs. Of course nowadays all of us use MP3 players to listen to music. Our computers seem to have changed quite a bit. Back in 1990 there was the desktop was sort of the main use for all of us, but by 2003 of course we had mostly found the convenience of laptops and nowadays all those things are pretty much done on our smartphones. And even the way we communicate has changed in these 23 years. Back when the Genome Project began the main mode of communication was the facts. I will point out, true story, when the Genome Project began and really for about the first six or 12 months that I was involved in some of the earliest efforts to map and sequence chromosome 7, I had collaborators elsewhere who were sequencing teeny bits of chromosome 7. And the way the sequence information was being conveyed to me so that I could design polymerase chain reaction assays was by facts. The facts with the sequence that I would look up and actually try to figure out exactly how to design oligonucleotide primers. It's astonishing in thinking about it and we quickly figured out more efficient ways of electronically communicating, but that was the means of convenient communication then. Of course by 2003 the world had changed and we were all e-mailing prodigiously, but now we've decided e-mail is too lengthy and so most of people are communicating through tweets. Well that's how we've communicated. What about science? How has science changed over that and how has genomics changed and how has NHGRI changed as the institute I now have the great fortune of leading? And then this is really what becomes now relevant for this symposium. These different eras for genomics and for NHGRI and I can't help but remind everybody that the way the Genome Project was completed was by following a strategic blueprint if you will articulated in several documents including the National Research Council report and also report from the Office of Technology Assessment. And that was the earliest blueprint laying out how to pursue the goals of the Human Genome Project. At the institute level we had leadership of Jim Watson who you'll be seeing more of later in videotape and Elka Jordan shown here was directing our extramural research program and serving as the institute's deputy director. If you fast forward then 13 years to the completion of the Human Genome Project it all happened with great fanfare and great celebration. And I can vividly remember April 14th, 2003 with the completion of the Human Genome Project we distributed to members of the attendees of a symposium held right here in this auditorium this DVD and in that DVD and this is shown the cover is shown the image is shown here and in that DVD included burned onto a disk the complete sequence of the Human Genome as just completed by the Human Genome Project and this became if you will a commemorative piece the Genome Project it was a it was a great stocking stuffer for several Christmases to come and actually was put in multiple is this true story multiple time capsules this was put into to be unearthed at some future date. As I mentioned we had a symposium here as we tend to do and and this was actually a two-day symposium and this is sort of some of the graphical elements from that symposium. Importantly once again we needed a blueprint for moving forward a strategic plan if you will and on the day the Genome Project ended came out this publication in nature from our institute that had wrapped up a strategic planning process and really served as a guiding set of goals and strategic ideas for moving the field of genomics forward. Down here is Francis Collins a little less gray as you'll see later today back then at this podium announcing all these things about I just alluded to and kicking off this symposium and then halfway through the day on April 14th of 2003 came a press conference just on the other side of the lobby out here that formally was announcing the completion of the Human Genome Project you have individuals like Mark Walpart who was soon to no longer be head of the Welcome Trust, Ari Petrino from the Department of Energy, Ilya Serhouni then director of the NIH, there's Jim Watson of course, Francis and Bob Waterston one of the directors of one of the genome centers that had been responsible for sequencing the human genome. And then we find ourselves here now in 2013 once again guided by a strategic plan that we actually published a couple years ago and very much articulates what we are pursuing in genomics some of which you'll be hearing about in talks sprinkled throughout the day and once again finding ourselves at a symposium commemorating celebrating but also looking forward to what the field is going to bring us and that's really why we have all gathered here today. What about the science? How have things changed over these three time intervals? And of course the thing that has driven this more than anything have been technologies for sequencing DNA 1990 when the genome project began some of those early sequences that were generated that were then put on pieces of paper and faxed around such as to me were generated using Sanger sequencing methods and radioactive sequencing and the classic sequencing ladder you'd see on an auto radiogram. Of course shortly thereafter and certainly what was responsible for sequencing the genome as part of the human genome project were more automated methods with imagery such as this reflecting Sanger based sequencing results. But wow as you'll hear about throughout the day I'm sure the world has completely changed with respect to sequencing technologies one of which is sort of shown in an icon form here but multiple different technologies are now available for sequencing DNA. And with that has come remarkable advances with respect to the cost of sequencing and the speed of sequencing. And you can think about it just in terms of sequencing a human genome how much time it would take to sequence a human genome or how much it costs. Well back in 1990 and throughout the human genome project we sequenced that first human genome. It took about six to eight years of active sequencing to generate that sequence and it cost something on the order of a billion dollars. But when the genome project ended had we gone back and immediately sequenced a second human genome our sequencing centered colleagues and researchers investigate sort of went back in the envelope to calculate what that might cost and estimated that if they went immediately to sequence a second human genome it would take probably about three to four months and it would cost much less only ten to fifty million dollars. But of course today today we can sequence a human genome with these next generation sequencing technologies for something like two to three days with promises that probably by the end of the calendar year that'll be down to a day and of course the price is well below ten thousand dollars is more like four or five or six thousand depending on how you calculate it very very much in route to getting to a thousand dollar genome we believe in the next few years. With that of course has come the generation of many human genome sequences 1990 there were none by 2003 you had your first but of course today there's thousands and and the number is growing and will continue to grow at an impressive pace. It's not just about the human genome sequence of course have come opportunities to sequence other genomes other vertebrate genomes back then there were none by 2003 we had several and today there's over a hundred and twelve vertebrate genome sequences available in public databases in terms of non vertebrate eukaryotic genome sequences back then there were none when the genome project began by the end of the genome project there were fourteen and now there's a four hundred fifty five and if you go to smaller genomes such as prokaryotic genomes the numbers are even more impressive from zero to a hundred sixty seven and today eighty seven hundred and I'm sure rapidly growing this is filled the databases of course if you just look in gen bank and you look at the total DNA bases in gen bank once upon a time we only had about forty nine million bases in gen bank by the time the genome project ended it was up to thirty one terabases and today about a hundred and fifty terabases and a lot of that data was generated with whole genome shotgun sequencing that came to the fore throughout the genome project uh... when the genome project began there was no such thing as whole genome shotgun sequence data available by two thousand three there was about nine point six terabases and today closing in on four hundred terabases of whole genome shotgun data available so of course that's a remarkable amount of data both about the human genome sequence and vertebrate sequences and other sequences and total amounts of of sequence data we also turned our attention to understanding how variation exists across the human population in terms of our genome sequences and those numbers have also grown remarkably just in terms of knowledge about single nucleotide polymorphism single base differences in our genome that are publicly available for researchers to use back in nineteen ninety we had a rather unimpressive knowledge of just a little over four thousand such uh... polymorphisms by two thousand three we had several million but of course today through efforts such as snip consortium and and the hat map project and a thousand genomes project that number is well over fifty million unknown human polymorphisms available for study those polymorphisms and other uh... aided by technologies and aided by knowledge of how our genome work has led our abilities to uh... be able to focus our attention to study uh... the genomic basis of disease we've seen remarkable advances both in rare genetic diseases involving single genes and more genetically complex diseases in the case of rare genetic diseases of course you could look at a two ways you could either look at diseases that we now know the molecular basis for or you could look at a gene level how many genes we've implicated in rare diseases and both ways you look at it it's impressive if you look at the number of diseases with known molecular penis type uh... molecular basis known uh... when the genome project began there were only sixty one diseases for which we knew the molecular basis but of course the genome project greatly accelerated that even during the human genome project so by the end that number was up to over twenty two hundred today that number is rapidly approaching five thousand if you look at it from a gene specific basis how many genes have been implicated with rare genetic disease when the genome project began the number was fifty three it had grown considerably uh... by the time the genome project ended to about fourteen hundred and seventy four and now that number is rapidly approaching three thousand in terms of complex genetic diseases uh... there's been similar advances of course this is a far more complicated endeavor to really get at the specific variants that are conferring risk for common genetically complex genetic diseases but what of course has come to be a very valuable strategy or these genome-wide association studies developing statistical associations between specific known variants and the inheritance of risk for getting a particular complex genetic disorder and these GWAS studies uh... where didn't exist back in nineteen ninety and in fact didn't really exist in two thousand and three there were other strategies but they weren't particularly efficient but now fast forward how many publications uh... have uh... been described successful genome-wide association studies over fifteen hundred and while we don't yet know the exact variants conferring risk for these common diseases in all cases or even very many cases we've learned a tremendous amount of where to search now in the genome to try to find which variants are the ones of biological importance and indeed much of this data has allowed us to then do replication studies to actually demonstrate that indeed some of these variants truly are going to be relevant for conferring risk for common diseases once upon a time of course it was zero uh... when the genome project ended there actually a handful of cases they weren't person they weren't found by genome-wide association studies but by other means but but now we have almost three thousand variants that have now been replicated as being disease associated now has that led to changes in the practice of medicine well little bits here and there i think the forward-looking talks you'll hear today will point a picture paint a picture about how things are going to be changing uh... as we think about uh... important ways of applying genomics to improve uh... medical care but there has already been some progress and there's various metrics one could use this is one just in terms of understanding the genomic basis for drug response and recognizing that people respond differently because of different variants uh... and uh... that may be relevant for selecting the proper medication for the individual patient if you just look at drugs for which the fda has now recognized the importance of having pharmacogenomic information on the labels for that drug when the genome project began uh... there were only four such medications the genome project ended that number was almost fifty uh... and now that number is over a hundred with again anticipation of that number growing with time so i hope this is giving you a flavor of these three time points across a twenty three year span from before the genome project uh... and really when the genome project began when it ended and then where we are today and and really what i want to do in really going through those numbers was just to set the stage to start to paint this landscape if you will the changing genomics landscape that really you're going to hear now put into greater detail uh... from the speakers that will follow so that's what i wanted to emphasize but i do want to also say a few additional things uh... starting with uh... huge huge thanks to a number of people who have made today's symposium possible i i really want to uh... give a uh... strong shout out thanks to a group uh... committee if you will of NHGRI staff uh... listed here who have made today possible in particular Rudy Pazzotti and Brad Ozenberger who co-chaired this group uh... and then at Sante who sort of handles all things logistic who's running around out there making sure everything's gonna happen perfectly uh... a lot of the graphics associated uh... that you'll you'll see and have seen in the program and so forth derelizia and then you're going to see uh... several videos uh... sprinkled in three of them uh... throughout the day and uh... Larry Thompson and his team have been responsible for these videos and a big thanks to them uh... for putting this together i think you're going to enjoy them tremendously these other individuals also thank you as well so the other thing i wanted to point out a sort of what the logistics are going to be uh... for today in terms of speaker introductions we knew you wanted to hear from the speakers much more than you want to hear from n h r i staff introducing the speakers and so we deliberately put bios of each of the speakers uh... in the program if you don't have a program please get one and so what we're going to do is not have detailed introductions of each speaker i'm gonna handle the morning session and just introduced the speakers and uh... at the completion of each talk uh... we're gonna if people have questions please go to microphones that are out there uh... in uh... on the uh... each aisle and in part we need to have people of microphones because we're videotaping all of these uh... all the talks and we want to make sure we can capture the questions uh... and then in the afternoon session mark guyer deputy director of the national human genome research institute will be moderating and again we're just going to mostly be introducing speakers and keeping uh... everything moving along and on time so i now have the pleasure though of introducing a special speaker who's the second one uh... and and i want to tell i don't don't take my slides now uh... i have one more slide i want to show and uh... and i want to tell a little story uh... before i turn this over to kirk and the story is really it's a it's a it's a feel-good story i think from the point of view of demonstrating how wonderful collaborations can happen within the government when good ideas are are are pursued uh... when i became director of n h r i three and a half years ago now one of the things i was very interested in was to continue to explore ways that increase uh... genomic knowledge uh... especially to the general public we're thinking about this in many areas but wondering how we could pursue outreach uh... knowing that genomics has become increasingly relevant to people especially as it finds its way into medical care and one of the things i always wondered about and i admit having now been at n i h for eighteen and a half years and raising children in the area was spending lots of time at the smithsonian especially with my kids wondering why was it that the national institutes of health which has so much interesting things going on the biomedical research arena and the smithsonian which is an incredibly impressive institution in its set of museums uh... they're only ten miles apart or so and yet you walk around the smithsonian you rarely see much in the way of information coming out about the n i h or collaborations of exhibitions uh... record that represent partnerships between the smithsonian and uh... and the n i h and so i uh... turned to vance bonham who runs uh... our education program at n h r and i said we should do something about this let's find out if there's something we can do with the smithsonian and we got uh... meeting uh... with uh... the smithsonian secretary secretary cloth uh... and some of his high uh... his senior staff we had a wonderful meeting exploring various ideas of what might be in terms of ways to have our institute in genomics interact with the smithsonian who actually have a lot of interest in genomics and uh... true story this this happened in june of twenty eleven and the secretary turned to me and said is there anything special happening in genomics that we could sort of rally around and do something big and i said funny you should mention that the light bulb went off in my head i had thought of it until that moment i said well there's this thing in april twenty-thirtieth twenty-thirteen will be celebrating the tenth anniversary of completing the human genome project let's do something let's do an exhibition together and boom it happened by a series of of remarkable meetings and developing a collaborations and partnerships and uh... and the rest is history although it's been very fast and furious on a timeline that usually doesn't happen for the development of exhibitions at the smithsonian uh... but uh... it's gonna happen and it's gonna happen very soon and uh... and kirk johnson who is now the new director of the smithsonian's national national museum of natural history uh... was fortunate enough to be able to get here today to briefly introduce you to this and tell you about this and so he's the first speaker and i'm delighted that he was able to come join and really be the first of a series of speakers in today's symposium so kirk