The following is a presentation of TFNN the morning market kickoff With your host Tommy O'Brien Good Tuesday morning everybody. I'm Tommy O'Brien coming alive from TFNN 906 a.m. We got about 24 minutes till the starter trading quite the day yesterday to the downside We have chairman Powell. He is in there for another term of four years The market digesting that news look to be positive territory come into that we zoom into the action on the S&Ps yesterday. There's a 30 we rally from about 4700 really about 47.03 We rally up 37 points almost 40 points to 47 40 10 15 a.m. The bell rings in terms of negative action opening bell had already been open for 45 minutes But we got two sell-offs yesterday from 47 40 down a solid 40 points above where we were Excuse me below where we were pre-market and then man that sell off in the last hour from 47 30 down about 50 50 points to a low as we approached the close yesterday of about 4680 and we're sitting basically at that price point overnight made it down to 46 54 Things looked a little dicey at about 3 30 in the morning over in Europe right now You have the Dax down three-quarters percent footsie barely positive cat girl down two tenths percent over in Asia Nikkei barely positive Shanghai boss positive by about two tenths percent as well Jumping over the Nasdaq 100 talk about some selling as well. We were approaching 16,800 We ended the session basically under 16,400 slightly negative action this morning We're down about two tenths percent right now treating it 36 We jumped to the Dow which is positive the only major index in the positive right now and check out the Dow Right now first sell-off pretty marginal second sell-off. That's an accelerated level You're talking about 300 plus points in the Dow all similar levels in terms of all the market selling off almost 1% In the final hour yesterday, we opened the markets right where we were at that close though the Russell negative by one right now Bitcoin up about a thousand a fifty seven thousand will call it within a hundred bucks or so that level crude all the talk today interesting action in terms of the release of Oil from the reserves of the US and many other countries as well in the market says thanks But what have you done for me lately and we're up almost $2. We talked to our man Teddy Kegs that Tomorrow at 40 past the hour. I'd love to get his take on the action crude and forex markets quite the volatile session I mean you just put this back on a daily right crude in August we're trading at 62 we make it up to 84 We've seen quite a decline keep your eye on it though right at the 3a2 interesting right healthy pullback folks when you trade up You know $23 over the period of about two months shouldn't be a drastic Recalibration when you get a $10 pullback with everything going on But really remarkable That release of the reserves from the US from India other countries as well The US is going to release 50 million barrels of oil from the strategic petroleum petroleum Reserve in an effort to combat climbing gas prices It's a short-lived fix if anything in a big way, so you got China Japan Let's pull up the article actually as we do that Release US oil reserves in challenge to OPEC plus 50 million barrels from the US from its strategic reserves now They're going to be replaced in 2022 2023 and 2024 so There's 50 million barrels of buying that is now in the market over the next two years by an administration Banking on the fact that some of the supply constraints probably fix themselves over that time Hopefully that's the case. We do not know as of yet But you have quite a coordinated level of that amount 32 million was going to be released Over the next several months 18 million will come from an accelerated release from previously authorized sales They said one of the biggest ever in terms of the release surpassing US intervention Interventions amid the Libyan unrest of 2011 and Operation Desert Storm 1991 and On that you have oil actually trading higher which is remarkable I'm trying to get into some of the other countries in the levels. I know India was in there with I think 5 million barrels Trying to see if they have those actual Numbers for the other countries Yeah, so you had 33.75 million barrels was the number on Operation Desert Storm in 91 so it's quite a release 50 million barrels Probably already priced in and here we go. So India is going to release 5 million barrels China didn't disclose its contribute contribution But one official said it would be relatively small 7 to 15 million barrels South Korea said it would decide on details such as volume and timing after discussing with partners But indicated it could be about 3.5. Japan's talking about 5 million barrels UK contribution Expected to be even smaller. So it looks like the 50 million the US putting in a big chunk of that to say the least But man that crude market, right? The market knew that was coming folks I guess that's the case or at least they were pricing it in they knew it was coming and it's saying probably that's The only reason we traded down to 75 to begin with from 85 was that we knew this is coming already We're back to 78 for crude remarkable acceleration Gold contract continuing to slide quite the slide for gold Now you do have a little bit of a pop in the last half hour So but man gold from the sell-off yesterday on the news of chairman Powell Getting another term from 1840 down to almost 1800 overnight with down to the 15 bucks to 1791 Now some of the gold stocks had hold up held up pretty well Yesterday, I mean you see the sliding gold, right? I was reading my dad's gold report So yesterday some of the equities Holding up pretty well in light of the run the gold had let's see if I can jump to some of the just mainstays I mean for instance NEM, right now it trailed off yesterday But you open down to This is just a random one a pick into 55 before you know you're back up to 56 50 I mean you see the bounce in a lot of these equities right from 930 until 1130 Now it's given up some of that as well, but when you compare that It's a worth noting, you know, you're talking about no real bounce in the gold contract during that time You were chopping around between 815 and 820 after trading at 1850 Overnight so still down about $30 no matter what the equities clawed back some of it You had a strong market yesterday, but gold overnight trading even lower down $14 continuing and we jump to notes and bonds As the slide continues there as well We're talking about lower prices and higher yields remarkable when you think about where we were on Friday quite a sell of 13108 as you don't often get a point and a half of movement in the tenure just that quickly and we're talking about a yield of 1.65% 1.65% I think yesterday at about seven in the morning. We're sitting at about 1.53 I believe coming in we moved to 1.58 pretty quickly on the Powell news We're now sitting at 1.65% and that's after getting a solid six point bounce off the lows We're at at 8 in the morning higher yields coming at you as the market digesting chairman Powell with four more years And it seems like more of the talk lately is about the potential To accelerate the tapering which is has the potential to accelerate when the next rate hike comes It seems like simple math folks if we weren't hearing all the rhetoric from the Fed Maybe if you had to make a decision without on the noise in the room And you said with inflation where it is with the numbers where they are What's the potential that we hold rates where they are? For the better part of at least the next six months. I don't know six months That's a long time to be holding rates where they are if this economy it has inflationary tendencies that are pushing Dramatic levels on a monthly basis even let alone year over year, right? I mean monthly numbers we got inflation at 0.9% you're looking at CPI even the core numbers 0.6% That's almost double-digit inflation on a yearly basis Doesn't mean it's gonna continue at that trend, but higher yields right now 1.65% stay tuned folks We got a lot to go over bear pack everything in the universe is governed by the Fibonacci sequence This mathematical principle is responsible for everything from the most aesthetically pleasing artwork to patterns in the stock market To stay on top of stock patterns You can take advantage of sign up for the Fibonacci 24 7 newsletter at tfnn.com When you subscribe You'll get a weekly report from veteran day trader Larry Pezzavento on stocks You need to pay attention to and you can trust Larry's analysis After all he's got 45 years experience as a day trader Larry will also provide daily charts videos and data on the key markets that he's tracking Expect notifications from Larry on market movement You need to act on at any time first time subscribers also get a 30 day money back guarantee If you're not satisfied, let us know and you'll get a full refund within 30 days of signing up Subscribe to the Fibonacci 24 7 newsletter today tfnn.com educating investors What's separating you from the most successful men and women on wall street? That's right information Having all the information gives us the perspective we need to place the right trades at the right time The TAS profile scanner is the premier market profile based scanner powered by its acclaimed task proprietary algorithms This feature rich scanner instantly filters over 2500 plus global financial markets Such as stocks etfs commodities futures and forex This powerful suite of tools leverages instant trade filtering and strategy formulation To show you emerging trades before they happen For a limited time you can save $100 off your first month by using the promo code Upgrade and you still get a 30 day money back guarantee. So you have nothing to risk Level the playing field with the TAS profile scanner, which you can find under the services tab at tfnn.com Sign up today Sharpening your skills as an investor is like getting better at playing a musical instrument You have to practice sure, but you also need excellent instruction from experts at tfnn You'll get advice and guidance from the authority and technical market analysis And it's not just dry tedious text either tfnn airs live financial content streamed live on tfnn.com and tfnn's youtube channel with tiger tv Live every market day from 8 30 a.m. To 4 p.m. Eastern for free Each host is an experienced trader and gives their take on the market while taking calls and questions live from around the world From the moment the market opens until the closing bell sounds tiger tv has eight different shows with expert hosts To help you make the right moves with your money. Watch online at tfnn.com or on tfnn's youtube channel And become the investor you were born to be tfnn educating investors Back folks. We have the s and p's right now negative one point. We got the nasdaq 100 negative 40 dow positive by 44 Let's jump over to our man kevin hanks every trading day folks folks noon eastern time kevin hanks tom white the team of td ameritrade network fast market breaking down the day's market action Setting up hypothetical option trades folks Trade management the whole deal walking you through it. I encourage you to check out the program We got some good earnings going on this week Along with everything else going on and kevin hanks. We got a new fed chair. That's the same fed chair. Good morning Good morning, tom. You're brian. Yeah, you know, I I'll be uh in the camp Like I think a lot of this market that was a little surprised by that choice I thought for sure he would go political and go with layl brainer um, but he didn't and so um, I think he went with the less disruptive Of a choice, but I think drone paul is the right guy I told you several times that I thought he's the most effective fed chair in my career. So, um Yeah, I think that I think for the market. That's the right call, but You know interest rates will probably go higher a little faster because he was considered more hawkish than layl brainer, so um A little less regulation than layl brainer would would have put in but maybe a little more hawkish in terms of interest rates I think that's why you're seeing interest rates climb To 164. I think his mandate is now on the table. So Uh, as we go into the you know, Thanksgiving week. I was just uh talking I'm a TD Ameritrade network and normally I would tell people hey the markets are going to get slower into the holidays, so Temporary expectations, but We're in kind of a new world. Tommy where machines trade a lot of the market. So they don't take Uh, you know sat wednesday after noon off and they don't go to grandma's house for Thanksgiving So the machines will be there moving the market one way or another. Tommy So you do have to keep one eye on the market these days And we we know Kevin it might um There's always on those low volume days You can actually get some real volatility when you don't have as much volume Because the influence maybe some of those movements could have if you don't have as many and i'm thinking especially of the friday half day Like you're saying There might not be as much volume on that day But sometimes that allows for even more volatility if there's less players in the market Maybe you meander back to the to the mean when we get back to the office Next week after Thanksgiving But back to the reaction because I agree with everything you said and it was interesting how The s&p's actually traded up now. We got two decent sell-offs throughout the day yesterday about 10 o'clock and three o'clock But in my head I was saying there's so many forces. They're always in play, right? And I completely agree. It's like, okay So you have chairman powell That was definitely up in the air with which was a big variable, right? It's like who was going to get it There was a real Opportunity for both of them I would say and so it was interesting right away the market didn't move that much and then the market moved up While you had yields rising and I said it's really interesting that I think Maybe the market was saying, okay We we have the the known factor of chairman powell versus the unknown factor of a new chairwoman Which the market doesn't like uncertainty So it was interesting you actually got a higher market kevin with higher yields on that news, right? But then I'd say the yields won out as and we got a pullback yesterday and we start the day kind of flat It'd be interesting to see where this market goes with higher yields probably coming at us That could be a good thing though If this inflationary track like some say man is is kind of heating up There's a lot more rhetoric sometimes I hear about maybe Increasing the tapering which is kind of interesting when we're so close to When they just announced the tapering what's kind of your take on that because I feel like I'm already hearing whether it's You know other fed presidents or just talking heads About the ability to increase the tapering of the asset purchases Potentially lining up a rate hike. I mean we just got that announcement and now it's only november 23rd And that's already the discussion.  Yeah, here's what I think about that tommy. I think Uh drone powell is probably gonna listen to these people and say thank you for your input But it's my call And at the end of the day Uh, it's going to be my name on this recovery of this academy not yours And so I would I think drone powell has a game plan I think he's going to stick to it And I think he's going to let himself be swayed by A few hawkish or more hawkish like james bowler From st. Louis that he comes out pretty consistently hawkish So I think drone powell's biggest mistake that he can make right now is raising it straights too quickly and Dampening this recovery. He's already done the first most of it right Which keeping the markets liquid now the biggest mistake he can make when he's all the way to the finish line Is to dampen the market too early So I think drone powell is going to wait till he sees the data that tells him not pre Uh prescribe A an action frankly And I think that's going to be the coolest part man watching these data points as we come into the holiday season man Is is you know supply chain woes is that going to be a problem? Is it going to be a problem hiring workers? Could that cause wages? Uh, just a cool time to be a trader in this market man with that many variables up in the air Speaking of variables, we have some companies out with earnings today man best buy kind of taking a tough one They're just dropping as I talked to you kevin from 140 to now sitting at 118 Um some movers today, but they're talking about margins out there as well strong numbers for these companies man But dealing with some some consistent problems that we're all kind of aware of uh the the season marches on What are you guys going to be talking about on the program coming up at noon today kevin? Today we got three good ones. Tell me we're uh first segment We're going to look at deer and company or john deer as most people know it and then we'll look at pure retail JW Nordstrom like fully those going to look at Nordstrom and then gap GPS so three really good names today deer that comes out with tomorrow morning and uh Nordstrom and gap stores comes out after the bell today Nice and taking a look at these charts, uh JWM Nordstrom We've chatted about it. We chatted about it back in the day with my dad and I would do in the program Interesting they have Nordstrom rack, of course, then they have Nordstrom Um, but you could say kind of underperform Nordstrom I got the chart up here man going back to the beginning of 2020 pre pandemic levels We're sitting at 40 bucks now. You're sitting at 32 you compare that to something like Macy's my goodness come in at 15 You're sitting at 37 different stories, of course, but even gap Came into 2020 sitting at 17. You're now sitting at 23 Surprising a company like Nordstrom kind of suffering. I like their brand. I do I shop in the Nordstrom rack Well, Kevin we look forward to the program as always man We'll be watching at 12 o'clock today and we appreciate the education as always Thanks for having me on Tommy. Have a great day. Always a pleasure. You too Kevin tune in folks It's a great education every day 12 noon eastern time. Kevin Hanks, Tom white They'll be walking you through the three equities And they'll be setting up those hypothetical trades and that's the best way to learn just going through real trade setups And the way they talk about, you know, we all have our biases folks You know, do you do you want to be the buyer volatility or the seller? Do you want to be the bull on the stock or the bear? Or do you want to have no directional position whatsoever and just be buying and selling volatility? We all can make those estimates in our mind The cool part is when you transition To set up the trade in the best manner possible to capitalize off of what you think is going to happen in the best way possible That's when I think you can get the risk rewards in the best manner because sometimes You know, you might be bullish Too flat on a stock. Well, yeah, you could sell maybe maybe if there's a ton of volatility and inequity And you're a little bit bullish to a little bit flat, but you don't see a pullback, right? Maybe you're selling a put spread. Maybe you're absorbing all the premium on the bottom side Now we talked about the best buy we're going to get into best buy when we get back If you were absorbing the premium on the negative side in zoom Well, you'd be the one paying all that premium All that price because zoom is dropping from 242 to 217. We'll look at zoom We'll look at best buy earnings when we get back. We'll go over some other equities. Come on back folks Are you having fun trading the markets? But having trouble finding like-minded individuals to discuss your trading and investment ideas with Become an apex predator in the trading markets and join the tiger's den trading room only at tfnn.com The tiger's den is an exclusive trading room where successful traders from around the world come to exchange trades and ideas Join the den and surround yourself with these sharpest minds in the trading world Subscribers to the tiger's den are also the first to have their questions answered live on air And can privately chat with our tfnn hosts live during their shows Interact with other tigers and tiger's as they share trading ideas news analysis and discuss the market action all trading day Subscribe to the tiger's den risk-free with our 30-day money back guarantee and become part of the tfnn trading community educating investors You could be making money off the stock market and if you're already making money off the stock market You could be making a lot more Check out tfnn and tiger tv and get expert investing advice to give you the power to control your financial future Go to tfnn.com and find the newsletter for you Whether you're into trading gold metals futures currencies or options You'll get advice and analysis to help you seriously get ahead tfnn also features trading services with a 30-day money back guarantee for new subscribers As well as tfnn's tiger den trading room trading software and educational webinars for all trading levels And make sure you check out tiger tv for free on tfnn.com Or tfnn's youtube channel for live financial content from 8 30 a.m. To 4 p.m. Eastern on market days Stop watching on the sidelines while other people get rich and become the investor you were born to be tfnn educating investors tfnn is excited about our new software charting program the art of timing the trade charts In collaboration with tom o'brien and using his best-selling book the art of timing the trade your ultimate trading mastery system David white has programmed an outstanding piece of software that will complement any trader's methodology Using this first of its kind program the art of timing the trade charts allows you to scan thousands of stocks For fibonacci formation setups including guardlies abc's butterflies and much more The art of timing the trade charts is designed to help you when scouring the markets for stocks Just beginning to form the trading patterns that many investors spend days weeks or even months Searching to find and right now we're offering licenses available at only $79 a month We are so confident that you're going to love this new charting software that will even give you a 30-day Unconditional money back guarantee don't miss out on this incredible new piece of software Get your copy of the art of timing the trade charts today by visiting tfnn.com This segment is brought to you by think or swim for more information Just click the think or swim banner on the front page of tfnn.com Well, welcome back folks We're going to jump right into dicks to start things off dicks put up some amazing numbers Remarkable the acceleration they're getting right now to lower prices 5.3% dicks is down on the open right now You got an initial pop higher a little bit on their numbers now taking a look at the context of this move Okay, we're trading at 133 we came into 2020 at 45 I mean that trend line is completely intact to the upside. Yeah, you could be bumping along the bottom portion Maybe definitely got a little bit ahead of itself on the last earning season But keep that move in context in terms of where we bend they put it on the daily All right, a little bit of a drop off But again, we're only back to where you were trading at Eight days ago on dicks sporting goods. Well, well now call it. We're only back to where we were 11 days ago As you drop a bit but again some context of the run this has had even Over the period of the last month Okay, dicks is traded from 120 to 140. Well, now you're at 130 You are off of the highs of 147 now getting into their numbers. Okay And this is just the superficial look of the numbers of a of a cmbc article versus a real breakdown Okay, but these are the headline numbers now. There's more going on in in dicks than the numbers i'm about to give you 319 a share versus a dollar 97 they crush it revenue They beat by 10 percent not 2.5 billion 2.75. They beat by 10 percent revenue exactly They had lofty expectations coming into these earnings folks, which is why it was so much higher in the three month period net income 316 million uh from 177 million a year earlier excluding items. There's your 319 a share revenue rose 14 percent to that 2.75 Uh, they took in 2.41 a year ago. Check out this one same store sales 12.2 percent the market was looking for 1.9 percent Can you imagine being an executive this morning at at dicks and you're you're trying to hope that you can push the market to see all of these But uh, they're obviously worried about Maybe it's rising costs in the future. Maybe it's it's supply chain woes. There's more going on for sure Uh, online sales rose just 1 from a year earlier. That could be a negative. Not sure what the expectation was there Uh Still up 97 on a two-year basis. So keep in mind they they have increased their online sales from last year When the world was still basically operating Online many stores weren't open. We were only five months into the pandemic keep that in context of of the the purchases were going on 97 2-year basis They're selling e-commerce sales about one out of five dollars that they take in is e-commerce up from 13 percent in 2019 As sales have accelerated and new customers have shopped its website Uh, dicks is invested in the business Uh Yeah, and they raised their outlook So they expect to earn 12 88 to 1306 per share on sales of 12.12 To 12.19 After adjustments For covert related expenses. It's going to earn 14 60 14 80 a share previously They were looking for earnings between 12 45 and 12 95 Right, so they jack up the earnings. They jack up the sales, uh Analysts have been looking for fiscal 2021 adjusted earnings per share of 13 13 So I guess that's the problem there. They're coming in at 12 88 to 1306 I mean all of those taken together Seems like a company that shouldn't be down 7.3 percent. This is more going on there for sure Let's jump to best buy now best buy watch out down 14 percent You give back more than just a few days of best buy quite a different story here on best buy shares check this out You just give back In terms of best buy is now trading at where you were trading at 15 months ago so much for the breakout not so quick We get over to best buy Declining gross margin. This was the story with target and with walmart You're seeing the biggest of the big having problems here keeping their margins when they're dealing with higher wages higher costs of good sold Uh Gross margin. Yeah, and as they say I hadn't even pulled it up walmart and target Um best buy said in the statement gross margin fell 0.1 percentage points talk about being tough 23.5 percent the market was looking for 23.6 and you're down 15 percent I think they think that things might be worse going forward folks The company cited the lapping of low levels of discounts product damages and returns last year along with more items lost to theft and other mishaps Uh Yeah, they're down dramatically Struggling to shore up gross margins after a recent stock surge raised wall streets expectations pull back and best buy shares Um, yeah big rally seven weeks so much for that earnings rose to a 208 compared with a buck 96 I mean the remarkable thing here is and we better you better be paying the attention folks is that they're beating on earnings They're beating on revenue and stocks are trading down seven seven to 15 percent That's not a good scenario for the market. Uh, you get the s&p's down 10 points right now. You take a look at the s&p's Very real threat that you're breaking out of that Uptrend channel now we've been in this channel well defined from may of this year And the s&p's up to september you break lower couldn't believe that we got back in that channel line We know when you're down here you think they're about the possibility of getting back in that channel line We potentially get a double top here. All right now. This is a daily You're looking at november 5th. We trade to a higher 47 11. We trade up to 47 40 You get quite a tail there on yesterday's action I mean it's always remarkable folks that there are sometimes events That have these peaks Okay, we found a new Fed share in the same fed share uh chairman paul getting another four years yesterday The market loved that for a moment until it looks like it's begun pricing in That we are going to get higher yields to the tuna. We're pushing 1.65 right now You heard kevin hinks is taken. I agree with it completely. He is data driven. He's not going to get ahead of anything My estimate though that might differ from kevin Just a little is that I think the data might force him in the next five months and we're going to find out But if we see cpi numbers that are pushing like 0.9 percent month over month for three months You might see the yields rise a bit and if you start seeing the market pushing those yields up forcing that action a bit It just might have to happen I mean if you're seeing that type of an inflationary environment folks You could see those yields start to rise It would make sense if you see those yields start to rise It's going to be a lot harder for chairman paul to stay at zero Till june of next year. It's a long time with a lot of data to come Through june of next year. I imagine he waits for that data But at some point the data just might force his hand And I think we all know that and that's what's cool about being a trader So we're going to get some really interesting data that could move the market in a big way now You want to talk about inflation. This is a perfect segue. I had it teed up How about 25 percent inflation? No more dollar dollar tree. They're going to be known as dollar 25 tree Now they're not going to be known as dollar 25 tree. They're still going to be dollar tree But they're going to sell things to the dollar 25 25 percent no wonder that stock Had been pushing higher on the news. There you go. Yeah, hadn't even pulled it up today Now this stock right really had begun accelerating already. They came out with their earnings. Is that today? Yeah, they're out with the earnings today. The market loves that idea now. I forget which I think this Was the news that they were probably going to have different Maybe pricing structure. There were a couple of news. Maybe there's an activist investor pushing them Um, I think it was here. There's a couple news stories All of it has to do with dollar tree raising their prices and they just traded from 84 bucks to 140 What is that? 60 70 pop in the stock over that period of time Uh remarkable that they're going to be able to get away with a 25 percent price hike It's like across the board 25 percent and they're saying well, yeah, they haven't they've been selling them for 35 years at a dollar Of course they have that's their store. That's what they do. Not anymore dollar 25. We'll be right back Are you in the market for buying or selling real estate in the bay area? Including the surrounding st. Petersburg tampa and clear water markets tiger real estate LLC is a firm that has extensive experience in the tampa bay area Whether you're looking to sell your current property for maximum value or you're in the market for a second home or investment property Tiger realty has the experience across all areas of real estate in the tampa bay area to help buyers and sellers Make the most informed decisions across all price levels from the price You should be paying per square foot in certain up and coming areas to the type of cash flow Investment properties are capable of creating tiger real estate can help you make the best decision When it comes to all areas of the market before you make one of the biggest decisions of your financial future Call tiger real estate LLC today at<PHONE_NUMBER> Or email us at tiger at tfnn.com. That's<PHONE_NUMBER> Call us today Technology around us is changing every day with so much happening. It can seem impossible to keep up with all the information David white's investment newsletter the technology insider Is designed to give you all the information you need to understand the technology that shapes today's markets and tomorrow's future David white has made his living staying on the cutting edge of technology His weekly newsletter will give you specific recommendations for value tech stocks As well as entry prices target prices and stops to set for each trade Dave delivers his weekly newsletters every friday with updates throughout the week You can get the technology insider at tfnn.com for only 37 in 50 cents Sign up for david's newsletter the technology insider and get an inside look at everything the technology sector has to offer Try it risk-free today with our 30-day money back guarantee tfnn educating investors Will the s&p 500 continue to climb for bold trades on us large cap stocks in either direction trade spxl spu u or spx s directions daily s&p 500 bull and bear leveraged etfs Direction leveraged etfs an investor should carefully consider a fund's investment objective risks charges and expenses before investing A fund's prospectus and summary prospectus contain this and other information about direction shares to obtain a fund's prospectus And summary prospectus call<PHONE_NUMBER> or visit direction investments dot com A fund's prospectus and summary prospectus should be read carefully before investing An investment in the funds is subject to risk including the possible loss of principal The funds are designed to be utilized only by sophisticated investors such as traders and active investors distributor foresight fund services Don't forget you can listen to tfnn live on your mobile device 24 hours per day Go to tfnn.com then hit watch tiger tv That's tfnn.com then hit watch tiger tv Welcome back folks and just like that We get markets back in positive territory a little bit of a quick pop there back to a five minute chart in the s&p Zoom in in on today's action. We make uh right out of the gate 9 25 We're low at 9 30. We're lower but things turn around at 9 35 and since then we've bounced Solid 15 points in the s&p's and we're actually above anywhere We were since about 5 a.m. Eastern time nasdaq 100 a little bit of a bounce as well Dow positive by 15 russell positive by one Let's check out some of the fang stocks real quick. See how we're trading you got tesla up 1.4 percent right now amazon been particularly volatile this week amazon coming into black friday always a big event for them up 1.2 percent We jumped to facebook shares down four tenths percent right now Microsoft shares down eight tenths apple going to be coming out with self-driving cars in about three years Okay, that's what they say, uh apple up to 165 yesterday. You're trading right now at 160 Volatile as well for apple shares uh jumping back to dollar tree. So dollar tree Look at that pop up another 5.6 today 5.6 percent today Uh, just jumping back to that article real quick because folks if if you can raise prices on the very Cheapest of retail which is the dollar store then you can basically raise it anywhere right because if people are shopping at dollar tree They're usually pretty price conscious going to the store loving the bargains loving the dollars Uh dollar 25 just doesn't have the same ring as a dollar But what do they say the company recently rolled out the higher prices and select stores wanted to make sure Uh, everything wasn't going to collapse. No it didn't collapse at all. Uh, those tests have demonstrated broad consumer acceptance of the new price point And they plan to bring it to more than 2000 additional stores in december and complete the rollout by the end of the first quarter in fiscal 2022 2000 stores In december they're getting there by holiday season folks 25 percent In a big way as that trades higher Okay jumping around to what else we got going on. Let's check back to some of the stocks that have their earnings I want to see how dicks is moving down 8.5 percent. I went over the number strong numbers for dicks Uh You look at that stock not that dramatic of a pullback. I mean you can make the the trend line Right and lines up pretty well along the bottom portion of these trends Still intact, but pretty much bumping up against that level. I mean it's an art not a science folks Where do you match up along the bottom? I like to do a little bit of almost linear regression Right making sure that you're kind of catching them all you're going to have a little bit of the peaks that might not reach The line you're going to have a little bit of the peaks that just might cross over the line That seems like a little a pretty fair representation of the bottom of that channel line of dicks and you're bumping right up against it Uh, that could be an area at least you could set your your trade if you're wrong you get out You don't give yourself much room, uh You know, maybe you see a trade down to 110 just keep that in mind And I don't think I'd set a stop that far Because you hit 110 you'd be below the level on october 11th But you're coming back to some huge volume on they had their last earnings to the upside And you're giving it back three months later Nothing to say that you might give it back if that's what you traded higher on earnings You could trade lower on earnings just as the same We jump over to best buy quite a different story for best buy no uptrend channel there We had a consolidation going on for the better part of 15 months best buy down 15 plus percent right back to that consolidation Some big big pullbacks there for best buy and they had some decent numbers as well Uh, but talking about margins margins slight miss on margins Uh, that's a big one and I imagine they have more going on for best buy as well All right jumping down the line for other stocks that are moving Uh getting into zoom So again, right the headline is beat estimates by two cents a share But slowing growth awari for this one. Uh, they called off their planned 15 billion acquisition during in the quarter, uh for five nine Exceeded analysts estimates and issued better than expected guidance But guess what not so much, uh buck 11 versus buck o nine. They barely beat 1.05 versus 1.02 That's a barely beat revenue increased 35% from a year earlier And the one that mattered the most in here is growing the larger companies that are really paying a big chunk I mean you can use zoom for free what they need to do is they need to get corporate customers That are going to be paying them a big number Uh, yeah, so revenue growth was above 300% as recently as the quarter that ended in january Now zoom has reported its slowest growth since at least 2018 Um before the 2019 public offering. Yeah, and here we go So zoom is reckoning with decelerate Decelerating growth because of so many businesses made their purchases last year I talk about one of my best friends is in the credit card processing business up in new york Uh, they process about a billion dollars plus a month of credit card processing They went to zoom kind of during the pandemic. They had been with another company. They got sold on it. They're they they have Somewhere over a hundred employees something like that. They had people at home. They have two offices They have one in new york. They have one in florida For some redundancy issues making sure that they're always up And they are using zoom but guess what they signed up last year Okay, those companies you were probably making those decisions last year Right if you didn't sign up last year as a company when you were getting your online business in order You're probably not signed up this year because you probably made sure that that process was in place when you needed it most last year Uh zoom is a strong company folks. I do have some zoom in a retirement account for some long term Uh position because in the long term, it's nice to get a growth company that's taken in a billion dollars Over their quarters and is profitable. That's the real key here You have a growth company that's profitable But you're going to see some volatility and you're seeing it remarkable this thing's traded as low as it has Zoom said that over 2,500 customers are spending more than a hundred thousand dollars a year up 94 percent from the same period a year earlier um Yeah, they talk about five nine in there as well But they are not growing the customers to the degree that they need to and you're seeing it in the stock down 16 percent Uh, you had a period there that zoom really broke out now. They broke out in the pandemic, but this is getting I don't want to call it silly, but you're at 200 bucks folks and at 100 bucks you're back to pre-pandemic levels Zoom might not be benefiting as much as the market anticipated During the pandemic, but it certainly has benefited and you came into 2020 at 75 You had a period of time that you were sloshing around at about 100 Uh, the market really took off basically April 6 the week of when you're trading at 108 And over the period about six months you almost pushed 600 on this equity Um, but this is getting to a point that if you're looking to get into zoom, um You know, it's tough to to buy it here because it was basically a one-way Straight shot from 140 to 205 But maybe you start to slide into it because anywhere it gets back to 100 bucks And I would be buying that equity in a heartbeat. Yeah, that's a 50 percent pullback But you've just pulled back from 600 to 200. So keep your eye on that Uh, and with that said, look at this market S&P is back to the short-term timeframe catching a bit We're at 46 90 right now now. Interesting. You're bumping up To yeah, right where we were To end friday's action 46 90 Uh, you know, you take back all the acceleration to higher prices on monday You take back the sell-off you take back the volatility this morning And the market is right back to where we were at the close of friday I mean, you're almost sitting in record territory folks record territory is 47 40 that we were at yesterday morning Um, this is really kind of a consolidation near the top here that we've been in Basically since november 5th, right the market sells off in september really reverberates back to higher prices in october That acceleration continues through the better part of the early part of november and since then we've just been chopping around About 4700 to the upside of the s&p's All right jumping over to the vixx as we get a higher market We got a vixx was above 20 back under that level 1916 now on that vixx stay tuned folks We'll be coming right right back to finish up the show Sharpening your skills as an investor is like getting better at playing a musical instrument You have to practice sure but you also need excellent instruction from experts at tfnn You'll get advice and guidance from the authority and technical market analysis And it's not just dry tedious text either tfnn airs live financial content streamed live on tfnn.com and tfnn's youtube channel with tiger tv Live every market day from 8 30 a.m. To 4 p.m. Eastern for free Each host is an experienced trader and gives their take on the market while taking calls and questions live from around the world From the moment the market opens until the closing bell sounds tiger tv has eight different shows with expert hosts To help you make the right moves with your money watch online at tfnn.com or on tfnn's youtube channel And become the investor you were born to be tfnn educating investors You might think that if you want to be successful at trading in the stock market You're going to need a crystal ball after all it's impossible to predict the future, right? Like any endeavor in life before you decide it's impossible get some advice from the experts You might find that it's not so impossible after all for daily market overviews that give you direction on the key indices Selective stocks and commodities subscribe to the opening call newsletter at tfnn.com The opening call newsletter is written by basal chapman creator of the trading methodology known as the chapman wave The chapman wave up down sequence gives you an edge in identifying price turns Finding the peaks and valleys and stock prices get the opening call newsletter by basal chapman and your inbox every day First time subscribers also get a 30 day money back guarantee If you're not satisfied, let us know and you'll get a full refund within 30 days of signing up tfnn.com educating investors Are you looking for a secured investment which pays you on a monthly basis The target first mortgage program may be the program for you The best rate on a five-year cd in the country right now according to bankrate.com is paying 1 per year or $1,000 per 100,000 invested the target first mortgage program pays 7 per year paid monthly on secured high value Buildable properties in st. Petersburg, florida The investment is for four years paying 7 per year or $7,000 per 100,000 invested Your investment is secured by high value real estate in st. Petersburg, florida Your investment can be anywhere from 100,000 to 500,000 Do you want to make 1000 per year on 100,000 invested or 7,000 per year on a secured tiger first mortgage? The tiger first mortgage program may be just the program for you The tiger first mortgage program pays 7 per year paid monthly for more information You can call<PHONE_NUMBER>. That's<PHONE_NUMBER> This segment is brought to you by thinkorswim For more information, just click the thinkorswim banner on the front page of tfnn.com Welcome back folks. We got the s&p's right now positive by 11 and who do we have on the phone? We got my dad on the phone. What's going on? Good morning Hey, Tom. How you doing? I'm doing good. How you doing, man? Good. I had to get in this inflation talk because you know, so check this out this I mean that 125 is amazing, right? Right. And I know that, you know, yeah, we are in the stock market Okay, but I think people should do There's a we've never been in this area. Okay for 30 35 years So there's a huge amount of money to be made On really understanding what you have in your garage What is out there on sale?  Okay I'm just throwing this out here though You know, there's bread to be made ought to be saved That is very common sense wise, which is pretty cool, man I mean, we we haven't had something like this happen. Do you know what I'm saying?  It's really worth $40. Right. Maybe you get it at $25, which is pretty cool. You know what I mean? Yeah Definitely, especially something that Depending on the inputs, right? I mean it came to my mind almost, you know A nice grill or something like that, an old Weber grill, right? Maybe something like that That's like, man, that's a hardcore steel. Those are always valuable. But yeah, something like that, man Those are probably going up big time. Right. Yeah, and everyone can do it And you know what the difference is the difference in this trade folks is that you are the market That's the difference in the trade, which is pretty cool. You know what I mean? It is not going to go make thousands Okay, but the bottom line is that It's a very efficient way of uh, basically Whether you're fixing up your house, whether you're doing another project, uh, there's there's real bread that's sitting everywhere right now Period. I think the dollar tree, like you said man, that one It's like if if those are the most price conscious shoppers out there I think because they're going to a store that literary has the price in the name Dollar and they said yeah, raise them 25% and no no big deal All right, man. We appreciate the call. Good to talk to you. Love you. I love you. We'll see you at three o'clock today Okay, bye. Bye. Bye man. Great. Bye. Bye. Thanks for tuning in folks.  We got our man Larry Penzevento at 11 fast market at 12 Steve Rhodes, Dave White and Tom will buy in this afternoon markets higher folks Interesting action. Stay tuned for basil. He's coming up right now


With the advent of personalized genomics, the incidence of variants of unknown significance, or VUSE, in disease-predisposing genes, is increasing. In the absence of standardized procedures to assess the pathogenicity of VUSE, targeted healthcare cannot be implemented for carriers and their relatives. Lynch syndrome is a prevalent, inherited predisposition to colorectal and other visceral cancers that is caused by a defect in one of the genes of the DNA mismatch repair pathway. Disrepair removes inadvertent misincorporations introduced in DNA during its replication. Here the replicative DNA polymerase has misincorporated a guanine instead of an adenine, opposite a thymidine. In wild-type cells, the guanine-thymidine mismatch is bound by the heterodimeric MSH2-MSH6 mismatch repair protein, after which the heterodimeric emulates one PMS2 mismatch repair protein is recruited. This protein complex initiates degradation of the misincorporation containing DNA strand, which is followed by resynthesis by the DNA polymerase, this time hopefully without making a mistake. In Lynch syndrome, a pathogenic defect in one of the four DNA mismatch repair genes results in loss of mismatch repair. This leads to the persistence of the misincorporations and therefore an accumulation of spontaneous mutations, including a hallmark phenotype called microsatellite instability or MSI. These phenotypes cause a dramatically increased rate of cancer development in Lynch syndrome. The profound knowledge on the genetics, cell biology and biochemistry of DNA mismatch repair and the availability of essays allows to investigate the functional activity of the pathway as a whole and of its actors. Diagnosis of Lynch syndrome is based on clinical criteria and the search for a pathogenic defect in one of the mismatch repair genes. This results with a pathogenic defect greatly benefit from surveillance and also may benefit from both targeted lifestyle measurements and treatment. In case a vuse is identified in one of the DNA mismatch repair genes of which pathogenicity cannot be determined, all family members, whether they carry the vuse or not, remain on the surveillance. This puts a great burden on the entire family and on preventive healthcare systems. Here we propose the development of a standardized diagnostic pipeline for vuse mismatch repair genes. This pipeline is based on the causal relation between defects in DNA mismatch repair and Lynch syndrome, on the profound knowledge of the genetics, cell biology and biochemistry of DNA mismatch repair and on the availability of essays to test the activity of the DNA mismatch repair pathway as a whole and of individual components of the pathway. To assess whether a vuse is pathogenic, the diagnostic pipeline proceeds to step two. In this step, the vuse is first analyzed by computer algorithms that are based on comparative analysis of the DNA mismatch repair genes from a wide range of species. Step two also comprises a novel, cell-free essay that measures the integral activity of the DNA mismatch repair pathway in a test tube. The cell-free DNA mismatch repair essay does not require patient material, is performed entirely in a test tube and is exemplified here for testing vuse in the MSH2-M6 DNA mismatch repair protein. The variant gene and its encoded protein are synthesized in vitro. Next, the variant protein is incubated with an extract from cells that are deficient for MSH2 and MSH6 and also with a fluorescent DNA substrate that contains a mismatch. Active mismatch repair results in the creation of a restriction enzyme cleavage site which can be quantified by automated fragment analysis. Loss of DNA mismatch repair activity is characterized by the absence of the diagnostic fragment and this provides strong evidence for pathogenicity of the vuse. In some instances, the step one and two essays may not provide conclusive results as to the pathogenicity of the vuse. In these cases, the diagnostic pipeline will proceed to step three. In step three, an additional layer of diagnostic essays can include an examination of other cell biological, biochemical and biophysical analyses of the DNA mismatch repair genes and their proteins. These essays often address more specific aspects of the protein function beyond measuring repair of mismatches. The step three essays require specialized expertise, laboratory facilities and trained scientific personnel. One example of a step three essay shown here, this essay measures correct cellular localization of the variant protein. As shown here, the variant MLH1 protein does not enter the nucleus unlike the normal protein. Therefore, this result supports pathogenicity of the variant. Step three essays cannot stand alone but they can provide additional evidence in favor or against pathogenicity in case the results from the step one and two essays are inconclusive. So how can we use the results from the step one, two and three analyses to define pathogenicity of a vuse in one of the mismatch repair genes? We propose to generate a software-based hierarchical decision tree that, based on the results from the different analyses, guides the clinical geneticist through a diagnostic pipeline. The software will evaluate and integrate the essay results and perform a Beezian analysis that outputs a pathogenicity probability score ranging from not pathogenic to definitely pathogenic. This will allow the clinician to make rationalized decisions as to the management of the affected individual and his or her relatives. DNA mismatch repair is one of the best studied DNA repair pathways and biochemical defects in this pathway are causal of link syndrome. These are available to study the activity of the entire DNA mismatch repair pathway and of its components. These essays provide a unique opportunity to develop standardized diagnostic pipeline for the analysis of the pathogenicity of vuse in mismatch repair genes. Such a diagnostic procedure will not only greatly benefit individuals suspected of link syndrome and their relatives but, moreover, provide an example for the translation of genomic data into targeted healthcare in the upcoming age of personalized genomics.


Good morning. I'd like to thank the organizers for inviting me to give this talk intro to 3DTE. Here are my disclosures. The objectives of my talk are first to review an approach to 3D echo data acquisition, and then I'm going to also discuss some common issues with 3D echo data set acquisitions and solutions for them. I'm going to use a combination of trans thoracic and transophageal echocardiographic imaging as the concepts for acquisition are the same regardless what majority you're going to use. The other thing is that the vendors will have different nomenclature. As long as you understand the terminology and what that means, you'll be able to optimize the images on your machine no matter what vendor you're using. Whether there's a significant difference in nomenclature, I'll try and point it out on my slides. I'd like to also direct the audience's attention to the guidelines that were published in 2012. There are new guidelines coming. They'll actually probably be broken down into two parts, one on valvular acquisition and analysis, and the other on cardiac chambers. So this is sort of the outline of what my approach to a 3D data acquisition is. I'm going to discuss each of these steps in detail, but overall the first step is to optimize your image and then to make decisions on acquisition modes. First, what size of pyramid that you want, and then second of all, depending on the size you've chosen, whether or not you need to go beyond single beat to multi-beat acquisition and then whether or not you want to add color doppler. Now your choices for acquisition mode are going to be driven by your need for spatial versus temporal resolution and whether or not you have the ability to deal with gating artifacts. Then I'm going to discuss rendering options, whether or not you want to crop your data set and whether or not you want to adjust your thresholds, and then finally I'm going to talk about how to display your image and whether or not you need to do any further analysis using software packages. So the first step in acquiring a 3D data set is to optimize your 2D image quality. If you look at the image on the left, you can see I've used multi-planar mode, so you can see the cross planes of this mitral valve as well as the 3D data set. And you see on the multi-plane those that in the left atrium, there's actually some artifact that is causing some noise in the left atrium when you look at your 3D data set. Now if you look on the image on the right, we've actually found a different angle where we have a much cleaner left atrium, and you can see that on that picture, the mitral valve is actually visualized to much nicer and you don't have any problems with the noise anymore. So once again, if you have poor 2D images, you'll get poor 3D images.  The second thing you need to do is you need to use multi-planar mode when you're acquiring your 3D. So here you can see that in this view, we're trying left ventricle. The top left panel is the view on your 2D image that you've used before you got into your 3D, that you're going to use for your 3D acquisition. The top right and the bottom left images are cross planes of that 4-chamber view that you were using. What you want to do is in all of these three views, your original 4-chamber view, your cross-plane in 2 and your short axis, is make sure the structure that you're interested in is in the pyramid throughout the cardiac cycle, insisting in data sleep, and then you also want to make sure that the definition of the structure is very clean during the cardiac cycle. And that way, once you've acquired your data set, you'll know that you have a good image and also, depending on how you want to cut through your image, your 3D data set, you'll be able to see everything that you're interested in. One of the things you can do to improve your image quality is try to image the structure perpendicular to your being. So this is why on trans-sophageal echocardiography, your mitral valve looks really nice because it's perpendicular to your ultrasound beam. And this is also why your aortic valve on the midisophageal view tends to not be as nice, and you deal with leaflet dropout, especially if the leaflet is thin and in a healthy person. Now, once you've optimized your image, then the next step is to decide what pyramid size that you want.  Now, in the early days of 3D, there were only certain pyramid size that you could use. They're relatively fixed. And then you can only do either single bead acquisition or multi bead acquisition with them. And this day and age, you can use almost any pyramid size with single or multi bead. And you can also do color Doppler acquisitions with either single or multi bead. Now, when you look at the machine, they're actually going to have different presets for the pyramid size. Now, these presets are more like starting points on current machines because you can increase or decrease the size of your preset, depending on what your object of interest size is. And so usually you want to use the zoom or the smallest size when you're looking at small, fast moving structures such as valves or masses. But remember, you've got to make sure that it's big enough to include some of these adjacent structures so you can orient yourself. I tend to use narrow sector or live if I'm in a procedure and I quickly have to get a larger area and including the catheters as well as the valve that I'm guiding the procedure for. And then I use wide sector mainly if I'm acquiring a left ventricle or the whole heart and I need a big data set there. This is a slide sort of telling you sort of the relationship between the different vendors and the terminology on their knobs in terms of the size of the pyramid that you're going to start with. Now, why does pyramid size matter? Well, it matters for two reasons. First, if you're actually doing volumetric measurements, you want to make sure that you capture both the largest and those the smallest volumes in the data set to create an accurate ejection fraction. So most vendors gate using ECG and they use the QRS complex. So that means N-dialy is usually captured on the 3D data set. However, if you have a low volume rate, then you may miss n-systole. If you miss n-systole, you're going to overestimate the n-systolic volumes and then underestimate the ejection fraction. The other thing is if you have a small moving fast moving structure, if you have a low volume rate data set, you may not actually see it in your 3D data set. And so that's why you want to get a higher volume rate to make sure you don't miss these fast moving structures, whether it be a vegetation or a mass. Now here I have two examples of a left ventricle and one is acquired, both are acquired using four-beat acquisition. The one on the left, you can see, is a smaller pyramid than the one on the right. The one on the left only shows you very well the left ventricle and left atrium. The one on the right includes the entire heart. So you can see the left ventricle as well as the left and right atria. And you see that on the left one, the smaller pyramid, you get a higher volume rate of 30 Hz versus the right you only get 20 Hz. When you look at the walls of the left ventricle as it comes in, you can see the one on the left with the higher volume rate. The walls come in much more smoothly than the one on the left. And that's because the one on the left is not sampling enough so that you can see now if you're only at 20 or even 15 Hz, how you could miss n-cisly and so get a wrong attraction fraction. Now I've alluded to this before, but there's a trade-off in terms of your relationship between your volume rate, pyramid size and image resolution. So if you have a certain structure, if you look at the panel on the left and it's covered by certain pyramid size, you get a sort of certain volume rate as well as an image resolution. If you increase that pyramid size to cover something larger and you want to maintain your volume rate, then you'll sacrifice image resolution if you look at the panel in the middle. To try and recover that image resolution, you'll have to decrease your pyramid size a little bit while you're maintaining your volume rate and that will improve your resolution. However, what if you have a structure that has to be covered within a certain pyramid size? You need a certain volume rate and image resolution. Then what do you do? This is where you need to move some single beat to multi-beat acquisition. Now, what is single beat acquisition? So single beat acquisition is the acquisition of multiple pyramidal datasets covering your structure of interest per second in a single heartbeat. Multi-beat acquisition, you are covering several small sub-pyramids that only cover a portion of your structure and you're then going to fuse them all to create your larger image that shows the entire structure that you're looking at. With high volume rate mode, what you're doing is you're actually it's an interpolation algorithm. So the probe, all the elements in the probe are not active and scanning at the same time, which is how you can get a faster volume rate. However, the blocks that are not being scanned, the machine comes up with an interpolation or a guess on what should be in that make the image look complete. And then in the second cardiac cycle, it tries to fill in that. And so that's why because it's guessing on some images and it's filling in with real pictures on others, that's why the images are not as nice as a multi-beat acquisition. So here I'm showing you a difference between the single beat versus multi-beat and high volume rate modes. So this is the left ventricle. If you look across the pyramid size, it's the same for all of these acquisitions, except the only difference is going to be where I use one beat on the left, four beats in the middle and high volume rate on the right. You can see on the single beat acquisition on the left, it's only six hertz. And so the walls of that ventricle as they come in, it's very choppy. It's not very smooth. When you go to multi-beat in the middle, you can see that the walls are coming in much more smoothly and you actually have a much nicer picture and you're getting a much higher volume rate at 23 hertz. Now, if you look at the high volume rate mode, you can see once again, you get a high volume rate of 23 hertz compared to the original single beat. But the image quality is not as nice as that of the four beat. Depending on what vendor you have, you'll have the different options for your acquisition until you just have to know what vendor you're working with in order to know what you can do to acquire a higher volume rate image. Now, one of the things I do sometimes, if I don't have the time to acquire or I don't have the ability to acquire a multi-beat acquisition. So here, you can see the ECG. You can see there's a lot of significant arrhythmia in this patient. So the multi-beat is going to end up causing me a lot of artifact and trouble. So I'm using a narrow pyramid and I'm actually sweeping. So this is a prostatic mitral valve. There's a catheter going through the valve instead of a paravalve leak that we're hoping for. And I'm scanning back and forth, actually, showing where the catheter is and its relationship to the interatrial septum. Now, why don't we use multi-beat all the time if it can give us much better pictures? Well, the problem is when you're fusing all of those sub-pyramids, is that you can end up with stitch artifact if the fusion is not done properly. So here I've got a couple of examples. If you look at the bottom left, this is a mechanical aortic valve and you see there's a stitch going right through the middle of the data set on the bottom right. You can see there's a mitral valve color data set and you see there's a big stitch artifact going through the valve there. And then on the top right, you can see this is the left ventricle. It's a little bit more subtle on this data set, but during cis-league, you can see there's a line going through the middle of the ventricle and there's the stitch there. So how do you address stitch if you actually need to use multi-beat acquisition? Well, first of all, acquire using this multi-view plane. So if you look at the color Doppler data set on the top left, it's a mitral valve and you can see that on the cross planes, you can see that they're black before the data set comes in. So we've acquired this data set too soon. We haven't waited for all the sub-pyramids to come in and then we haven't waited for them to fuse properly before acquiring. And so you won't see the cross planes coming in on your main image. You have to use the perpendicular planes to your sweet plane to actually see this. So this is why multi-plane is very valuable. The second thing is you have to see why the cause of your having these stitch artifact. Is it because the patient's moving? If so, try and stabilize the probe and ask the patient to breath hold. If they're ventilated, try holding the respirator to see if you can get your multi-beat data set before ventilating the patient again. And sometimes you can't do anything and you'll just have to use other single-liter high volume rate mode to try and get your image. Now if it's because of an arrhythmia, sometimes you can find a spot where the arrhythmia is more quiet during the acquisition and then you can use a retrospective acquisition setting where you freeze your cine plate and then you trim your data set to acquire the fused beat. Or you once again, you may have no choice but have to use single-liter high volume rate acquisition to get your data set. Now everything I've described for non-color 3D data sets also applies to color 3D data sets. The one thing you have to be aware of even though there has been progress in this area is that with 3D color data sets, you still have a drop in volume rate. And so sometimes you may have to use a smaller data set when you go into the color part, like a smaller pyramid, or you have to go into multi-beat.  If you crop before you acquire your data set, all the information you've cropped out cannot be regained after you've acquired your data set. If you crop after, all that information is still there. However, the problem is then you've acquired a larger data set than you really needed, and you so may end up with a smaller temporal or spatial resolution that you, or smaller, sorry, temporal resolution, than you wanted. Okay, so you'll have to make a decision about that before you crop. Now, there are a couple of different methods to crop your data set. If your object of interest is aligned perfectly within your data set, then tools such as AutoCrop, which automatically cut your 3D data set in half into the middle of your pyramid, wherever it may be, are useful. EmbarkCrop, which crops along the x, y, and z axis through your data set are good to use. But if your data set's acquired a little bit off axis or the structure you're interested in is actually not aligned perfectly perpendicular or parallel to your x, y, and z planes of your 3D volume, then you may use to use something like a plane crop or a view crop, which gives you that flexibility of tilting over a little bit and cutting in these off-axis planes. So sometimes the mitral valve may be aligned properly, but the tricusp valve is a little bit crooked, and so this is where that comes handy if you want to look at tricusp valve anatomy. Now the tool that I use a lot that's actually very handy is these quick crops or that let you just crop on either side of your object of interest, and then everything outside of those two lines is excluded. And then the structure that you're interested in usually for me, it's a valve, is just there available for you to actually look at. Now there are newer tools available on the machines. This let you quickly click on the 3D data set and then your cross planes are seen. Mostly the vendors also have these options for automated view cropping. You take a very large data set where you cover everything that's in the heart and then you have to do some sort of initialization where, so that way they know where the structure is located. And then you can just hit like a four chamber view and it'll crop automatically to the four chamber view or the mitral valve. So once you've cropped your data set and you can see the structure that you're interested in, then you have to render your data set. Now what does rendering mean? So if you think about it, you're taking a 3D structure and then you're creating a 3D data set. But most of the ways we display our 3D data set is actually on a 2D video screen. And so what the rendering does is actually make this 2D image look more 3D like. And the main three things that you're going to adjust are usually going to be your gain, your smoothing, and your brightness. Now there are other modes that are available on these rendering settings that can make things look more like tissue light or like there's a light behind the data set to improve your visual license. And all they really are is just trying to make that data set look more 3D like. Now gain is the main one that you're going to be adjusting a lot of the time. One of these you have to realize that if you over gain, you end up with a lot of noise or snow on your image. If you under gain though, you're going to have drop out of your tissue and then you won't know if that's truly, is there perforation? Is there a gap there? Is there a cleft? Or is that just because you've dropped your gain too much?  Now there are two ways of adjusting your gain. First is overall gain. So this changes your gain everywhere in your data set evenly. Then there's the regional gain. Regional gain is usually only adjustable before you acquire your data set. So you have to adjust it when you're setting up your image. I usually, for regional gain, I'm playing with my TTCs and I'm decreasing the gain in the left atrium when I'm looking at the mitral valve and increasing it as a level where the leaflet tissues are. The other thing I adjust a lot is smoothing. So smoothing is if you, lets you see the fine details of the structure you're interested in. You don't want to decrease it too much. So if you look at the image on the left, we've decreased a little bit and you can see the sort of the structure of the amplaster device so you look at the top left. However, the problem is if you decrease it too, sorry, increase it too much, then you end up with too much, or sorry, you decrease it too much. You end up with too much granularity and it's too much noise on that picture. If you increase it too much, you smooth out all the details and so you can miss a lot of the finer structures that may be there that you want to see if you look at the image on the right. And then brightness is the last rendering tool that you should adjust to try and improve your image if you are having issues. Now brightness, you kind of think of as a flashlight. If you make it too bright, then it whites out all your structures and you lose that 3D depth. If you make it too dark, once again, it's too dark and you lose that 3D depth. And so you want to increase it to just improve that 3D ability or 3D-ness of your picture. Now finally, color. So a lot of the times when you acquire your 3D data set, the color is everywhere. One of the quick tools that I actually like to do is I change the color filter. Now when I increase the color filter, this lets me see the mange up but I lose the smaller jets in the picture so you have to be aware of that. But it lets me quickly see where I am in the middle of a procedure and where the jets are coming from so I can optimize that quickly. Once you've rendered your data set, then you have to describe how you want to display it.  Your display, most of the time now we've talked about volume rendering for the display if you look at the top right. However, you can actually analyze your data set and create models, either be a mitral valve model or a left ventricle model. And then either present a surf rendering or wireframe rendering of that model. The other thing is you can do slices through your 3D data set and present it as such. Now there is a lot of work being done to actually let these 3D data sets be presented in a 3D manner. Some tools that are being used now include stereo glasses or stereo monitors to let you see the 3D shape. There is work being done with holographic displays. One of the things that is actually happening for a lot of pre-planning for procedures is the 3D printing mode. And then very popular right now is development of virtual reality or augmented reality tools. So in summary, these are the steps that I would recommend for acquiring a 3D data set. First, you want to optimize your image. Then you have to make a decision on your acquisition mode. The first thing is the pyramid size. And then once you've decided upon your pyramid size, is the volume rate high enough? Do you have to go to multi-beat? If you have to go to multi-beat, can you deal with the gating artifacts? And then whether or not you want color or no color on your image. After you've decided your acquisition mode, then you want to decide about cropping, whether or not you want to crop before or after, and then how you want to crop.  Do you want to adjust your gain, your brightness or smoothing, or perhaps change the characteristics of the tissue. And then finally, you want to decide how you want to display it. And then whether or not you need to do any further analysis to get more quantitative measurements from your data set. Thank you.