Oh, you're like the brightest person I know. Should I put on another light? I don't know. I'm low. This is my problem. Is it like my options are this? Blair, or this? Yes. We should be telling Halloween stories with your dark lighting. This lighting blows. Hey, everyone. We are here with our lighting issues with our. Oh, no. I'm glad I said blows. You did say that. So that's fine. Yeah, I almost said something else. I'm glad I said blows. What would you have said? Oh, I don't know. A good word for public facing like we are right now. We try to be family friendly. We do this show for you, your family, your friends. We hope you're all sitting around that nice, warm. Ooh, not a campfire. It's like 100 degrees in Portland right now. How's that heat dome, everybody? There's heat and fires all over the place. I hope that wherever you are, you are staying cool, staying sane, and getting ready for the science. Yeah. We all ready? Yes. Yeah. This is when you check the microphones and say the words. Oh, testing, check one, two. Is it on? Can you hear me? Thank you. Blair. Hello. Welcome. I'm excited to talk about things. Thank you, yes. I am glad you are excited. I am glad you're excited. I'm excited too. Let's start the show. Everybody, are you ready? Beginning the show as soon as I opened my iTunes because I had not done that yet. It's a good thing to remember to open the iTunes when it's time for the music for the start of the show. We're starting the show. In three, two, this is Twist. This Week in Science, episode number 837, recorded Wednesday, August 11th, 2021. Do you have climate concerns? Hey everybody, I'm Dr. Kiki and tonight on This Week in Science, we will fill your head with bargain shoppers, freeloaders, and maniacs. But first. Disclaimer, disclaimer, disclaimer. Cause and effect. Poke a beehive and you get angry bees. Load the atmosphere with carbon, you get a greenhouse effect.  Everything happens for a reason, which begs the question, what is the cause of people who are ignoring global warming and COVID-19 precautions? In the case of global warming, it's pretty obvious. The fossil fuel industry is the major contributor of carbon emissions, has funded marketing campaigns against science and is a major contributor to politicians who refute science, despite the fact that it threatens so many lives if not dealt with. Cause and effect. We saw this in the past with the tobacco industry. When big tobacco was paying politicians and marketing campaigns and they were funded so to keep people smoking, despite all of the health risks. But what about COVID-19? What causes campaigns and politicians to refute the science, despite the fact that there are so many dying as a result of it? Well, the answer isn't yet clear. It one day maybe will be. And I'm guessing institutional real estate investment syndicates, but we'll see, we'll see. Despite causing and profiting from disinformation that directly and predictably leads to the deaths of thousands, they will get away with it. Like the oil industry, like big tobacco, and just like this week in science. Coming up next. I've got the kind of mind I can't get enough. I wanna learn everything. Discoveries that happen every day of the week. There's only one place to go to find the knowledge I seek. Good science to you, Kiki and Blair. And a good science to you too, Justin Blair and everyone out there. Welcome to another episode of This Week in Science. We have returned with our binders overflowing with science. Our pockets full of napkins, but quickly jotted notes. Hopefully we can read better. That's exactly so many. Our hats full of rabbits. No? Nope. I don't know. Unless you wanna join my underground resistance, I've decided that everyone has to wear bunny masks and we're gonna call it the Warren. Well, that sounds like fun. It'll be fun. It'll be great. Do you wanna join? Can I go full bunny costume? You can go full bunny. That's great. What if I show up dressed as a fox? Ooh. Blair. That's pretty good. We'll find a place for you. That's fine. That's fine. Welcome, everybody. We do actually have a lot of science for you tonight. I brought stories related to that climate thing that's been going on, but I also have some freeloaders. I have also chimpanzees and little lady mice. Justin, what do you have? I have a mystery on Mars. Why the Matrix first pitch? Not the movie that got made, but why the first pitch of the Matrix movie may be coming to a reality? How to reverse aging through microbiota and a potential reversement or cessation of masts of cancers. Oh. Cures of cure treatment. Possibly from the path to opening a door to a venue that may one day exist. Yeah, yeah, yeah.  Yeah, we'll talk about that. All right, Blair, what is in the animal corner? Oh, in the animal corner, I have bats and frogs, but also I have a quick story before that regarding maniac robots. So it really is Halloween in Blair's animal corner, and I remind that we are in the middle of August. It's always Halloween here. I'm looking forward to all of these stories. Every day is Halloween, right? As in the name and lyrics of the old song. But if you have not yet subscribed to This Week in Science, you can do that very easily looking for us. All places podcasts are found. Look for This Week in Science. We are also on YouTube, Facebook, and Twitch. On Twitch, we're Twistscience, T-W-I-S-C-I-E-N-C-E, same name on Twitter and Instagram. And our website is twist.org. All right, on with the show, let's dig in to some of the science. Okay, I didn't wanna talk about this story because we really talk about this subject all the time on the show, but this really is the biggest science report of the week. It is the sixth international panel on climate change assessment report that was released this week. The IPCC has released a report analyzing over 14,000 scientific studies, over 700 scientists volunteered to input information to write the report to assess all of this work and to boil it down into something understandable for policymakers. And I mean, you know, if you've never listened to Twist before, and this is your very first time, welcome and hello, but additionally, you might not know as much as everybody else who listened to the show regularly about the dire straits that we are in pretty much, but the long and short of it is that there were a few updates to the sixth assessment report. Things that hadn't really been talked too much about before, regional differences in how climate change is going to affect different areas. So for instance, the Pacific Northwest burning a lot more and getting hotter and having less precipitation. Same for California, but other areas getting a lot more precipitation, winds changing, coastal areas being affected. So the regional aspects of this report are very, very insightful and should be useful to policymakers in regions around the world. So what's the good news? Okay, well, the take home is. Is there any, I hope? The take home is. Taking a no. Climate change is here, and it's our fault and we need to reduce our carbon dioxide. And there are a lot of other greenhouse gases involved, but basically, if we can reduce our carbon dioxide output to at least the Paris Accord levels, if we can do it more than that, that's great. But if we can reduce our carbon dioxide output, then we will be on track to limit the amount of warming that takes place in our atmosphere around the globe. We will be on track with reducing the extent of warming to reduce the impacts of all the other climactic effects that will occur. That sounds great. If we reduce, we'll do better. How much do we have to, what is the level of, what is the urgency in the timeline of? Right about now, we are on track for about three degrees worth of warming and that's more than we want. That's more than we had initially been like, talking about at this point, like when we were first talking about this many moons ago, it wasn't that, it was like, oh, by one degree by the end of the century, we can, now we're talking three. Right. Yeah, we're about on track for three degrees. Give or take a few, this is, there are always errors baked into this because there is a bit of uncertainty. Yeah, every time though, we've only gotten more degrees. We haven't been like, we're taking one off. That's not true. They actually, in one of the midterm reports that came about, there was an increase. They thought we were gonna go up to four to six degrees of warming, but they've since dialed that back and now they're looking at, like right now it's about at three. We should just wait for the next one. But three degrees of warming is still going to lead to triggering cascading effects because we will reach the thresholds within the climate that will lead to things like, you know, ice shelf instability that will lead to massive amounts of ocean level rise to the ocean expansion that occurs with heating. There are going to be biological effects that affect life on the planet. Forests are going to retreat. There are gonna be more fires. The more forests retreat, that means less habitat, less ecosystem and less ground cover that produces wonderful clouds that has a cooling effect, less carbon storage. There's all sorts of things, more desertification, like bad stuff. But I don't want to focus on the bad stuff because that can just get us dooming and glooming and we'll be like, ah! But what I found really, I guess, inspiring from this is that things are a much more certainly known factor at this point in time. Where it used to be a lot more debatable, it's not anymore. We did this and it's in our power to stop it. I think it's, yeah, I think it's interesting like the IPCC report, the first few that came out, you had to really be clued in to science to even hear about it. And I even remember the 2016 presidential election. Climate change was not spoken. Those words were not spoken in the presidential debates. Oh, it's, yeah, 2008 science debate got started, which is a nonprofit that tries to get the debates to include science in the questions and they fought really hard and could not get climate onto the debates in 2008, but since then, yeah. Yeah, I mean, everybody's talking about the IPCC and nobody knew what that was five years ago. So I do, you know, awareness is the first step and we've made huge strides on that. So the next step is to get people to buy into kind of what it's gonna take. But of course the problem is you need to get people to force the powers that be to buy in because really it's not up to the individual. It's up to the community and it's up to the system. So I could say right now I wanna buy an electric car that I don't have a place at work or at home to plug it in. So that's kind of- Right, and then where is that electric power coming from for the electric car? There are so many factors that it is a large and complicated problem, but there are solutions. One study out this week, John Timmer over at Ars Technica wrote about an assessment looking at the dirtiness of power generating plants around the globe. And you can think, oh, coal power plant, probably pretty dirty, but some were built a long time ago, are not very efficient compared to others that are more recent and have more recent technologies. So the assessment found the, if you got rid of the 5% of the dirtiest power plants around the globe, that would take care of about 75% of the emissions from power generation. Whoa. Just the dirtiest plants. If we can get our, I mean, we're passing an infrastructure bill right now. If we can get our infrastructure bill to, and others moving forward, to support decommissioning inefficient power plants or making them more efficient, adding carbon capture. Another aspect that they calculated was that if we were to put carbon capture on a lot of these dirty plants, it would substantially affect the amount of carbon dioxide that is released into the atmosphere during the power production process. So there are things that we can do, that we can, that are solvable, that are like, right here, right now, this is something we can fix that'll have a major impact because one of the places that we have the largest amount of emissions isn't just the generation of power that we all use, that everybody uses. That's a massive impact just by cleaning things up, getting rid of the broken toys, you know? Or fixing them, you know? Let's upcycle everybody. That's good. Why does my car have to be smogged, but these power plants don't? That's a really good question. Why are we working with old technology when we should be updating our infrastructure in such a way to make it work better for us? And the answer to your question, Blair, is because the power plant is not in your backyard. It's not in the valley. It's not in the city that you're not seeing the pollution. So that you take care of. But the thing you don't know that's going on, you don't see, you don't smell, isn't affecting your air, it's completely ignored. But this is one of those points when we start to realize, oh yeah, everything has effects on everything else. So even though you can't see it and smell it maybe, that power plant is absolutely still affecting your environment. I'm still kind of curious about that statistic. I don't know if you have the drill down on it, but the 5% of poorly efficient ones, how much energy are they putting out? Because if they're inefficient and they're the same size as everything else, they could only have maybe 1% of the energy output of all of them. But if that 5% that's old and inefficient are the biggest behemoths, they could have 20, 30%. So that's the kind of thing. It depends on where you're talking about, like which plants you're talking about. Some of them are really big old plants, some of them are smaller. Just wondering what that 5% produces even, compared to the rest. Right, the total amount of megawatt power production by those plants. That's where you could decide maybe like, yeah, instead of spending money retrofitting anything or upgrading anything, shut them down and just build municipal solar power plants or something. Put solar panels up instead of. So solar is another direction, wind is another direction, but as we've seen also from the infrastructure bill, the another direction that is being funded that I haven't heard talked about in quite a long time, but seems to be it's been percolating and is coming back up is the hydrogen economy. And within the infrastructure bill, there is money that looks to be set aside for research and development into regional hydrogen hubs and also into creating a cleaner hydrogen economy. Because one of the issues with the hydrogen economy at this point is that it's still dirty. We're making our hydrogen from methane and it releases a lot of methane in the process and there's other byproducts. And so there's a lot of greenhouse gases still involved and it's not clean. The hydrogen that we're using is not necessarily clean power. And the ways that we would get the hydrogen cleanly are still expensive. We don't have the right kind of cheap catalysts at this point or yeah, they're just dirty. We don't have other ways to make it. There's a type of turquoise hydrogen that is being discussed at this point in time, green hydrogen and turquoise hydrogen that are cleaner, but they're still not just hydrogen from water. There's electricity and electrolysis and a lot of energy that goes into producing the hydrogen in the first place. But hydrogen itself does have the potential to drive a shift in our energy economy. So that's something that's being invested in currently which is interesting. I think, I have a strong opinion about this. I think pursuing hydrogen is dumb. It's a false choice. It's wait until the animal corner. This will make sense. It's a decoy.  Well, what about this option? Then you can still pump gas. Then you can still like, it'll be similar, but it's a little better. So wouldn't you rather do that? And it's just rip the Band-Aid off and go for clean energy. I do not understand why we're not. It's frustrating to me. Because I think, yeah, it's frustrating and I think you're right because one issue within the whole green economy, sustainable energy sector is greenwashing. And that's the idea that companies say it's gonna be so much better and it's going to be helpful and the other natural gas. It's a transition fuel that'll keep it going, but it's, oh my gosh, it's warm in our atmosphere very rapidly as well. We're extracting it. Amplifying water and causing earthquakes. Yes. And making land fall. Yeah. There was somebody, the people who advertised for hydrogen gas is so genius. I bet if you asked a random person, they would say like, oh yeah, water vapor comes out of the tailpipe. Perfect. Perfect. That's not the whole story. No. Wait, there's more?   Right. All they've done is connect that to something that's burning fossil fuel. So it may have any electric car when your town's electricity comes from a coal power plant isn't the solution. It's sources. It's better. It's still better. But that's not how it is. I don't know that it actually is. It depends on that plant. It isn't because if that plant, hang on, if that plant is burning coal without any sort of exhaust system, if it's polluting, burning coal, that's the same as driving a car that has coal. It's not the same. It's the same thing. No, it's not. It actually is. Maybe it's worse. All right, so right now, the US Secretary of Energy, Jennifer Granholm, has launched the Hydrogen Earthshot Program, which is a program that is aimed to create, this is technology agnostic, aimed to create greenhouse gas-free hydrogen production at $1 per kilogram before the end of the decade. And if they fund it, if they fund the R&D, if they fund the experimentation, if they fund also the small batch tests that need to occur to help like they did with solar and with other technologies, if they subsidize it to help it get to a point, it is possible that hydrogen could be clean and inexpensive. But it's not yet, and that is the big point, and we all need to be aware of the greenwashing effect and whether or not that is happening, and we need to hold our government and the researchers to and the companies who become involved in this to a very high standard, because this is our future, and we can do this. As my very first climate change summit I attended when I started as a little climate change educator so many years ago said, it's real, it's bad, it's us, but there's hope. There you go. And I will also say there are several studies. I dropped the links in chat that said that. Chatroom says Blair's right. Is 100% funded by or powered by a coal grid, it is still cleaner. I will point out, talk about greenwashing, you did pull up a Forbes article. So I'm just saying, if you're going to greenwash, that's where you would do it. That's exactly what we would go to. Get that out there. Triangulate your research people, multiple citations. There are three in there. OK. I think there's more. Chatroom agrees with you, I agree with you. Let's move away from solutions to this climate conundrum. And I want you to tell us about a mystery that popped up this last week. Yeah. So it's not a local mystery. This is taking place on Mars. And right now, from what I understand, you don't really know what happened. So perseverance is a little rover up on Mars.  So it's automated. And you can go around. And it's going to drill into the Martian soil. And it's going to take these rock cores and just deposit them. Later, there's another mission that's going to come and pick up these rock cores and then bring them back to the earth so we can study them. Very fascinating. So they had their first run. And they kind of brushed away the robot brushes away the surface dirt a little bit to get down to the rocket. And he runs this core in, pulls it out, looks at, points the camera at where it drilled. There's the hole. Then it goes looking for the core. And it's gone. It's been swiped. Something has taken the core. Or maybe something else is what's happening. But they have like the core itself is empty. The hole is there. But there is no little deposited rock core on the ground anywhere. So the Strelts were trying to figure out what happened. They think there was some sort of reaction with the atmosphere. It may be that the rock core that they were grabbing was a lot less solid than they thought. And it's basically turned to sand or dust and just blown away once it was removed. The fun part is they really don't know. And this is so far 0 for 1. I guess this is like, it took one shot and it's already failed. So hopefully, hopefully we will get to keep trying and get some of these cores out there so that we can have this other mission that's already planned to come pick them up. But right now, top people at NASA, top people are working on this. Isn't the highest probability that it was just dusty and it just crumbled away into dust? That was my initial like, yeah, you got something that seemed solid, solid enough for the rover. Fine, the driver didn't sink in or anything like that. Solid enough that when you were drilling it. But yeah, just kind of a sand, basically, or even like some kind of a limestone kind of thing that you didn't even know was enough to powderize it. Then maybe that's all that happened. I feel like we need to have, what is it, scorpions? Scorpions, what are you whistling and saying scorpions for? I don't know, there's like the, maybe I'm conflating 280s songs, like Blowing in the Wind kind of things anyway. But here's the other thing, here's the other thing. It sounds like dream wiener is what you were saying when you were whistling out there. There was another, we had, we sent like a scorpion, we sent like a mole. That was the, we had a, I can't remember what it was called, but there was something called the mole. NASA insight. Insight, thank you. Insight was supposed to be like a little burrowing robot. That was supposed to, but couldn't, like kept trying to burrow, but for some reason just failed to burrow. The ground was too hard, they couldn't get into it. The ground was too hard. Where they landed, they thought it would be good and then it wasn't and insight doesn't move. So they're doing other things there. They had backup plans. It's doing other things. They should send something over and just drag the mole over to where perseverance is and then see if it can do its job. There's a switch spot. Let's see if that works. Yeah, what I think is really fascinating is, yeah, we're not there. It's a robot. We're looking at things through cameras and the robot's like, I thought I had a core. I don't have a core anymore. What's going on? All we have is the visual evidence. So if we don't have the video of all of the dust blowing away as the core sample was taken, yeah, how does it, how does it solve itself? But you never know till you get there. So it's a rover and it can go someplace else and it can dig another place. Well, but the thing I didn't realize that I learned from the story too is that this event is that it's completely automated. It's not getting instructions to dig. And apparently I guess there's no manual because the first thing I would wanna do is just dig, let's dig here again, let's dig here again and let's see if we can get some remnant of this thing. So it's automated, but it's not like it decides completely by itself where it's going to dig. I thought it was. People here on the planet, aren't people here on earth are like, this is a great place to start and they hit the go button and then the robot has all the stuff installed. It has the instructions to know how to start the process and if it's gonna pick up the core sample and move on a certain distance to another location and dig again, it has all that information and can do it completely autonomously. Yeah. I did hit the go button right away. I wanna see, I wanna know right now why are we working with, what is happening? Dusty ground. Cause if it was just sand type thing, then they wouldn't have the hole necessarily. Like it's kind of nice. It's right where the core was. There's the hole there. Another rover came over and kicked it out of the way, obviously. Oh yes, obviously. Obviously. This is just a lesson that the next time we have a rover that's gonna be taking core samples that we need to have it equipped with a little spoon as well. So it can just shovel up anything that it drops. And some milk, don't forget the milk. Don't forget the milk. All right, Blair, what do you have? Oh no. What did you wanna talk about? I have tiny robotic maniacs that can climb slopes, move against fluid flow and deliver substances to your neural tissue. Nope. No thanks.  No. I already have a maniac in my cerebral spinal column. Oh. Well, if you didn't know, maniac stands for magnetically aligned nanorods and alginate capsules. So. I did not know that. Thank you. I did. It's just any. Let's name it maniac. Anyway, maniacs magnetically aligned nanorods and alginate capsules might be part of an advanced arsenal of drug delivery technologies in the future. They can be controlled by a magnetic field.  It's important that they're soft so they can move across tissues and against fluid flow. They can climb slopes.  So they can climb slopes and they can move around neural tissues like the spinal cord without hurting it and deposit substances at precise locations. So obviously delivering drugs orally or intravenously is difficult. It's difficult to target specific things like cancers or neurological diseases in neuronal tissue because then you're kind of delivering it systemically. So that might affect regions elsewhere on the body or other parts of the nervous system unrelated to the disease. So really to be able to deliver drugs to the exact precise location in the nervous system is really important. And so that could help lead to improved efficacy. It could reduce side effects. It could even help with re-administering drugs that normally you can only administer via crazy surgery. So the main problem to this point with using robots for this is in controlling their activities as they travel through tissues in the body. And so this tumbling robot helped them see how they could handle moving across real tissue. They have these magnetic nanorods. They're encased in soft spherical shells and they are being controlled by an external magnetic field and go to a very specific site for drug delivery. They tested them climbing slopes with increasing steepness and moving against flowing liquid. And then the last step is they actually obtained rat brains and mouse spinal cords to test their ability to move along those tissues. They deposited dye on the surface because obviously if it was dead rat or a mouse there wasn't a lot of point to administering drugs. But it could have been a real drug. Yes, yes. That's proof of concept here, yes. Exactly. So this is obviously very preliminary, very experimental but they think they've demonstrated strong enough evidence that small soft capsule based micro robots or maniacs have potential for controlled local delivery of drugs in neuronal diseases. So yeah, I just thought it was very cool. Nanorobots in drug delivery for some reason, I know I'm like afraid of some technologies and robots doing things, but this seems perfect to me. I've always been very intrigued by the nanorobots for drug delivery. I think it's great. I like the very targeted aspect of these kinds of systems where it's not just gonna be all over the body. I mean, that's one aspect. It could go everywhere and deliver a drug everywhere and get into all the nooks and crannies and crevices that it needs to in your body. But the other aspect is like this, magnetically controlled. There have been others that have been controlled in different ways, but being able to target them in very specific areas for very specific therapeutic solutions is that I think gives it a lot more sense. I was trying to- Rick in the chat room. Go ahead. If you think of how we treat a cut, if we did it as systemically as we take drugs that go everywhere in the body, you get a cut on your finger and you're like, ah, quickly wrap my entire body in gauze. This is the solution. It's the only thing we know how to do. Yeah, every pill you take. It's ridiculous. I don't think it's ridiculous. So this is exactly the idea. Rick Loveman in the chat room says, nanoepidural anesthesia. When we give epidurals to people who are giving birth, usually their legs go numb. Wouldn't it be nice to be able to deliver it so specifically down to the nerve where that would not be the case? And also to reduce the possibility of paralysis because you're so specifically getting into a location.   That's a whole different conversation. Completely different conversation. Yeah, this is fascinating. Little maniacs. Maniacs in the CSF. Yeah, inject me full of nanorobots so they can deliver the drugs exactly where it's supposed to be exactly what I need it. That sounds great. That sounds fantastic. Yeah. You know what else sounds great? What? Reversing our ages. What if we could go backwards in time? That sounds like a story that I've read! Yeah, tell me, Justin. So this is actually not gonna seem too incredibly earth-shattering to longtime listeners, but the microbiota regulates a lot of human immunity and brain health we have been finding out over the years. As humans age, there are dramatic alterations in our immunity and our brain health, but also in our microbiota, which is linked then to that poor health and elder populations. So there is, we know that there are connections between gut microbiota and our health, but we don't exactly know the mechanism. We don't know all of the things, the levers that are being pulled, the chemical communications that are taking place. So scientists kind of went and looked at some things to study some of those solutions for human health in mice. This was a mice study. Not a people study. Not a people study. What they did is they did the fecal microbiota swaps. They transplanted either from a young mouse, three to four months, or an elderly mouse, which was 19 to 20 months old. So the older mice, they put the young mice, they put the young mice poop in the old mice, and lo and behold, there was age-associated differences in peripheral and brain immunity, as well as hippocampal metabolome and transcriptome of aging recipient mice. So the old mice started to get the effects of youth just by being filled with the fecal transplants of the aging mice. Finally, the young donor derived microbiota into a selective age-associated impairments and cognitive behavior when translated, transplanted into an aged host. So basically it reveals that there may be they're actually saying this might be a, right, just stop there. We may have found a suitable therapeutic target to promote healthy aging. So at least stop short, and at least the abstract here, of saying, okay, we understand the mechanism now, and it just went, you know, we should just do this. We should just, why are we doing this in humans to study that? Sign me up, sign me up immediately. It's the fact that we don't have poop hills yet in modern medicine. They do exist. Dr. Justin, it's not a real doctor. Poop hills are still on the market. No, it's honestly, you know, this might be a little too much personal information, but I was having a lot of stomach problems recently, and I went to the doctor, and at no point did the doctor want to look at my microbiome. And I just, it's not part of common practice yet. And I think it's insane. Well, we don't really, it's not part of common practice for assessing general gut microbiota population makeup because everybody is different, and if they don't have, and you know, a before you had problem sample, it's hard to know what exactly is off. They could do a sample to determine whether or not it's, you know, you have an overgrowth of a more toxic bacteria, for example, but that then still doesn't get at what the cause of that problem is. I think they, I think they take the sample annually. It's not enough yet. They track your microbiome, and then when you have problems, any problems really, systemically in your body, they can check that and see if the balance is off from when you were healthy. Yeah. I think the, I think the issue is that, yeah, they don't have, they still don't have diagnostic, information backing them up. So with a liver enzyme, there's a whole sea of papers that have been developed that say, okay, if your liver enzymes are doing this, or you're doing that, or your blood cell count is this versus that, here's what might be going on with our patient. But the microbiota is still like, well, that's interesting. Here's some interesting information. Yeah. There you go, how about it? But so instead of possibly having a fecal transplant, which they do use therapeutically in some situations for people who have really extreme bowel issues, chronic bowel issues. Like, what can we do? I mean, how do we maintain our microbiome as we get older? And is it that we can maintain our microbiome or which has caused an effect? Is it because we're aging and our body is producing more metabolites that it is changing the environment that will hold a healthy microbiome that will allow us to be youthful? Which is cause and which is effect? What's the feedback loop? There are a lot of questions here, but. But once it's clear. It's solved.  Well, yeah, but this is the fact that, I mean, they were able to show, like we've done it with like skinny mouse, obese mouse, knockout gene stuff going on there. This is, this one is demonstrating that if you have somebody who is having elder onset mental health issues, perhaps, brain health issues. Yeah. This, I mean, people think as a gut transplant, it's for the gut. It'll make your gut. No, it's actually might be able to affect a whole range of other possibilities. Yeah, well, there's the whole gut brain axis, right? And we are learning more and more about the connections between the microbes and the metabolites and the ways that the bacteria and the gut affect what's going on in the brain and how the brain affects what's going on in the gut. And there's all sorts of neat stuff there. Yeah, yeah, very interesting. Keep your gut forever young. I'm just gonna sing songs from the 80s, this episode. And I've got a story about freeloading cats. And it's a pretty quick story because, I mean, cat, everybody thinks of cats as freeloaders, right? It's like, oh, you've got a cat. They're not gonna work for anything. They're using you, right? I mean, that's not exactly true. There are relationships that we have with our cats and Justin may scoff at some of these ideas. But! I've had cats as pets. I'm not, they were for my friends. It was like that. Give me your friends. I'm not totally... A lot of animals that have been studied with respect to the amount of work that an animal is willing to put in to get their food, many animals would actually rather work for their food than just be fed.  It's just what they enjoy doing. So these researchers from UC Davis studied a bunch of cats and gave them little cat toys, food mazes and various things to see whether the cats would be more or less likely to work for their food. And not that they wouldn't work at all for the food. And like some of them would go play with the cat food mazes to get their food, but more often than not, the cats just want to eat and they don't want to work for it. Who knew? Well, may I animal explain this for a second? Please animal explain Blair. So predators, they work really hard to take down a kill, but then they eat as much as they can. Like they will like fully gorge themselves and then not hunt again for, depending on the animal and the take days, weeks. So that's one lifestyle. Then you have foragers and grazers, things like giraffes and you have scavengers, which are kind of wolves, essentially. And so those animals are spending all day, every day looking for food. And so I think that has something to do with this. It's not just cats. I would guess that if you, my experience with big cats, for example, is pretty similar. So I definitely think that part of it is just their adaptation to how they eat. And so if you're used to spending all day, every day foraging and I give you a bowl of kibble, then you're bored. But if you're used to eating and then sleeping for four days, you're fine with that. That's totally great. I'm going to go lie down now. And I think there's a slight misnomer. Like for a domestic house cat, there's no work around the house that a cat does. But for the most part, dogs aren't really doing any work for anything either. But if you got cats out on a farm, they're working. They're out there catching rats. They're keeping pests away. They're knocking down vermin. They might be even taking them. But they're not often eating them. Oh, they're killing them, but that's their job. Right, but that's what I'm saying. It's a separate, that's fun versus food. That's different parts of the process. I think that's the whole, yeah, that's the whole thing that Claire's bringing up. There's the getting, the acquisition. There's the eating. And then there's the post-prandial nap. Yes, yes. So we've taken something that is for outdoor vermin control. That's probably why humans, there's toxogondii in ancient Egypt, mummies. Like we've been around cats for a really long time. But there's probably to keep, they probably had most of their cats hanging out around the grain stores or something. They probably had them working, doing that kind of work. Brought them indoors, we've got it sealed off. There's no room, there's nothing for them to do. What are they, they're waiting for the job.  Get them a catio, train them. These are things you can do. Let a live mouse loose. Let's see what happens. See what happens, see if they don't go to work like that. No, I have a feeling my cats would not go to work very quickly at all. Maybe. This is This Week in Science. Welcome. Thank you for being here. We're so glad to have you here joining us for another episode of Science Fun. We were just talking about cats, but how about a little COVID? Mwah! Mwah! Mwah! Oh boy. I don't have a lot of COVID, just a little COVID. All right, so a study has come out assessing the long-term effects of COVID-19, and there are over 50 long-term effects of the disease, ranging from hearing effects on your hearing, fatigue, headache, attention disorder, hair loss, dipsnea, which is difficulty breathing, loss of taste, loss of smell, coughing, sweating, all sorts of a 55 potential long-term symptoms. The big take related to this, though, that is, I think, the most interesting aspect of this, 80% of symptomatic cases result in at least one long-term system, symptom, 80% of cases, that's a lot. You know what doesn't have 50 long-term effects? Getting vaccinated? Yeah. Wearing a mask? Yeah. Everyone's talking about the long, we don't know the long-term effects of the vaccine. We do know the long-term effects of COVID and it's bad. Yes, long-term effects of COVID are not great at all. So just playing games with what's worse, I'm not gonna play games with it. Long-term effects are not something to think about. And as we're thinking about long-term effects, one of the groups of people that has brought up a lot more in conversation recently, as once again, school is returning to session in many places around the country, it already has, and classrooms have been shut down and classes have been sent home to isolate and quarantine because of COVID outbreaks in classrooms at this point. There's a concern about long COVID in children because the Delta variant is more transmissible and being more transmissible. We are seeing more children in the hospital with symptoms. One thing that can be done is ventilation in classrooms. Kids who cannot be vaccinated. And actually any room that indoor space where people are congregating, ventilation can play a major role in clearing out the viral particles, clearing out those aerosols that we release when we breathe, speak, sing. There's yet another study that came out this week confirming that fine aerosols are generated during talking and singing. So if you're talking and singing in the classroom, consider that children, you as a teacher, may be releasing these fine COVID particles, SARS-CoV-2 viral particles into the air. What happens to those particles though, once they are in the air is a big question and that's where a study out of MIT has looked at ventilation in classrooms and provides suggestions for keeping classroom air fresh. Now you can have heating ventilation, air conditioning systems, HVAC systems that are huge, that maybe have filters that are able to manage the airflow, but ideally windows and doors can be open and ventilation can be increased. In classrooms, kids wearing masks are mostly going to be breathing out and the viral spread is not going to be horizontal because the masks will block the horizontal spread from their face. Instead, the spread will be vertical in nature. So kids are going to be breathing, the in the masks and the airflow will be vertical, which is going to lend itself to vertical movement of the air up to the ceiling, where if you have filters and fans and all the stuff sucking into the air system, that's great, that air can be taken out of the room and that will minimize the amount of viral transfer from student to student. These windows though can be a problem in cold weather and they tested a system where they had cold windows and they found that the warm bodies in the classroom and the warm air tends to rise and all the ventilation goes up, but then the cool air along the windows will drop it back down again. And so students that are seated next to windows. That was me daydreaming looking at the window. Maybe more prone to infection to COVID because of the way that the air moves in the classrooms. Now they say that if windows introduce baffles that can direct the air more directly down to feet, then air can come in from outside and the whole air system circulation can be shifted and can address some of these problems. But in all of this, each classroom is going to be different. We need to do what we can to improve ventilation knowing that in the winter, there will be issues with cold air outside, warm air inside, and lots of little warm bodies doing a lot of breathing and talking and maybe even singing as they are preparing for those winter plays. There are a lot of considerations and I think it's very important that our indoor ecosystems are starting to address all of these because COVID isn't the only airborne virus. It isn't, there are a lot of these things and if we can clean it up for COVID, it's gonna clean it up generally. A lot of these practices can help maintain health and sanitation for looking into the future. I mean, we're talking about a future school. Future school that has windows and HEPA filters and HVACs. Yeah, no, really.  Well, and what happens when it gets cold and then you don't want to have the windows and the doors open? Right. Then everybody stops saying any words with the letter P. Make a couple of adjustments. Atric, is Atric here? Atric, Atricson? Well, yes, but anyway, this is an article. It is published by MIT in the journal Building Environment, but we will be linking to the FISORG press release on our website. So if there are any teachers who are interested in sharing this with their schools or people who are looking at going into indoor work environments and want to share this information with their building managers, I think that this is the kind of consideration that science looking at how things work at works experimentally and kind of checking our assumptions about how things work can help us adapt and create better environments for everybody. Moving forward. That's it for the COVID update. For this week, I don't want to talk about all the bad scary stuff. So I'm solutions focused today, everyone. This is This Week in Science. Thank you for listening. Thank you for watching. If you're watching right now online. And if you enjoy the show, please consider heading over to twist.org and clicking on our Patreon donation button. The Patreon button will take you over to our Patreon community at patreon.com slash This Week in Science. And at that location, you can choose your level of support anywhere from $1 a month to $1,000 a month. We like to dream big. Whatever amount you choose, it's going to help us continue to bring you science every single week in our conversational and friendly format. We want to continue to do this and we want to bring it to you. We hope that you will help support us in this endeavor in bringing science and curiosity to more people. $10 and up. And we'll thank you by name at the end of the show. Thank you for your support. We really can't do this without you. And now we're going to come on back to that wonderful time of the show that we like to call Blair's Animal Corner. With Blair. She loves our creature. Great as all. Biped, milliped, no pet at all. You want to hear about this animal. She's your girl. Except for giant pamphlets grown in Animal Corner. What you got, Blair? I have a story about bats and how they make choices.  You go to the movies. Remember that? Go to the movies? You go to the movies.   What would you get? You told yourself you were going to get the small. The extra large one, it's such a better deal. I'm getting so much, but I didn't know that until I saw how small the small was in comparison to the price of the big one. I'm getting the red vines because I changed my mind entirely. Now, the Kiki doesn't want to play the game, but if the... I got frightened by how little difference there was dollars compared to volume of the container.  Oh, you know, in that case, that's a lot more money. You get the small. I still stick with the small, that's really all I need. This is an actual thing. This is called a decoy. The medium is a decoy choice, and it pushes you towards the more expensive, largest option because it suddenly appears to be a bargain. And this apparently is how coffees are priced. Popcorns, travel decisions, even voting options. This kind of false or decoy middle choice is what pushes people to the extreme. Yeah, this is exactly the playbook of a major appliance retailer that I worked for for many years, where we would put those three next to each other, the good, better, best, and good, better, best without the one in the middle. You're right, doesn't work. You gotta have the little stair steps up too. In some cases, in fact, the entire appliance, like if you went into the washer dryer, the entire appliances were laid out from good, better, better, better, better, better, better, better, like everything kind of went up a little bit all the way down the line to the most expensive one so that you could sort of just slide up to a higher priced but more featured product. Right, so this decoy shifts attention away from the initial decision. And so this is something that's obviously been well documented in advertising, I guess, in humans. But it's something that Claire Hemingway, who recently received her doctorate from the University of Texas, wanted to look at in bats. Now there are frog eating bats. They're very rational about their diet choices. And then there are some fruit eating bats that live in the same area. That actually have less preference for their food. So frog eating bats very opinionated about their food choice.  So with the Jamaican fruit bat, our tibious Jamaican sis, they'll eat any sorts of fruit.  And they're really important seed spreaders.  They also don't like to dine alone. So for this experiment, she had to catch a bunch of bats in misnets in the forest and then set up dinner parties of three or four bats at a time. Oh, I love this. Yes. Then one by one, so they wouldn't be influenced by each other, she'd pull one out, presented them with food choices and recorded their choices. She named the bats. Are you ready? Arturo, Aria, Bianca, Barnaby, Calvin, Cruz, Elisa, Fiona, Fernando, Gabriel, Grove, Heidi, Huxley, Ivan and Isabella. They were named alphabetically by cohorts. Love it. When they were given two choices, ripe bananas and ripe papaya, no preference. When they gave them a third choice, unripe banana, they almost always chose the ripe banana. I would too. Who wants an unripe banana? Yeah, but why are you ignoring that papaya? That's the problem. So the presence of the decoy, the unripe bananas shifted their focus and changed their behavior. Meanwhile, the frog eating bats, track hops cirrhosis, evaluated each of the food options she offered them, but they were not influenced by dietary decoys. They made rational decisions about what to eat. If they chose A over B and B over C, they would also choose A over C. So they really followed a strong preference. And so their choices did not change depending on which options were offered around each other. So that means, first of all, that some bats are fooled by this decoy and some are not. And that also means that they have factors like their diet or how they acquire their food that might produce rational or irrational behaviors. So predators, like a frog eating bat, they go after prey that they actually have to hunt. They might have evolved different decision-making strategies than animals that just go up and eat any fruit that's lying around. So that could kind of push them to have different opinions about types of food. The her next step for her post-doctoral fellowship is to ask the same questions with bumblebees. You wanna find out what drives bumblebee behavior and see if the same decoy mistake exists in bee reasoning. This kind of study helps appreciate animal abilities. Of course, it allows us to tease apart the factors that go into human decision-making as well. So if this is something that we do and these other animals do, we can start to kind of draw logical lines into why it happens. How do we choose between resources? How does our brain work when that's happening? And then how does the way we perceive the world influence the choices we make? I also think it's really important to know this when you're looking at animal conservation. Because if something happens to an environment that adds a new choice or wipes out a choice, it's helpful to know how that's going to impact foraging strategies in animals. So I think there's a lot going on here. It's really interesting. I also think it's so funny. I've definitely fallen prey to the decoy trap many times. So I think that's the interesting aspect is that we share this cognitive, I guess, this trick. It's not a trick. We can be tricked by it. This maladaptation, is it? How does it help us? Why is it something that we share with bats? Why do they have the same effect? And if invertebrates like a bumblebee, a honeybee have the same effect, why is it so widespread between completely distantly related taxes? So that will be really interesting to discover. I would think that it comes from a survival instinct, a necessity within all creatures, all living things, to take advantage of opportunity. Like the simplest form, you have an opportunity and you then maybe see this slightly better, easier opportunity. It's also that, okay, that's the better opportunity I'm going after that. And then you're getting there and then there's an even better opportunity, right? And so you go after that opportunity. But whatever it is, that chain of chasing, like if we instinctually took the worst option every time or the, you know, passed by opportunities, probably wouldn't be here. No life form would. All life is on some level. Take what you have as opposed to. Take what you can get. Yeah, take the better option. Yeah, but in this, I think in this case, papaya is not better than banana or vice versa. And I think that's what makes it so interesting is, you can say that like in the human choice, you're trying to get value, right? Yes. But the papaya and the banana were both equally ripe. Sure, sure. But it triggered better opportunity because it had the comparison of the two bananas. You're comparing the not right banana with the right banana. Yeah. So it's triggering suddenly that's the best. And that's the, you know, not even the ape brain. I don't know how far back we have to go. Yeah. Or about to find out. Yeah. If it's the bubble B brain. It's like all the way back. Sponge brain. Yeah. How far does it go? Take the better option. Over here. Slime mold. You don't even know. There's only one. What was it? A mango? There's only one mango. Is it the good one? Slime mold. Is it a bad one? I don't even know. There's not another mango by which to compare this mango nests, but I know the better banana. Yeah. The best banana. See the slime mold would just split into multiple pieces and take it all. So yeah. I will take all the opportunity I can. Yeah. Yeah. But speaking of, yeah, sponges, what about sponges inside your body to protect from poison? Isn't that a birth control method? Not anymore. University of California, San Francisco, Stanford University and the California Academy of Sciences, so a tree of universities in my neighborhood have uncovered new clues. So not the whole answer, but just some clues as to how poisonous frogs and birds don't kill themselves.  This is an amazing question. They're poisonous. Uh-huh. Yes. Yes.   How do they not kill themselves by doing these things? Yeah. So for example, the golden poison frog, truly beautiful. You should Google it. Phylobates terribilis is estimated to carry one milligram of the sodium channel blocker, betraco toxin in its skin glands.  How do they fill their body with that? What is that? Wait, wait, hold on. What is that ratio? One milligram? One frog, 10 to 20 humans. Oh my goodness. That cute, tiny, little adorable. He's like big, too. You can't understand. He's like the size of a cat in a little tiny package. Yes.  Yes. And I will also mention if you ever see one of these guys in a zoo or in an aquarium or a science museum, they themselves are not poisonous in that museum or zoo or aquarium because they obtain the toxin from the insects they eat. So because they're being fed little feeder crickets and things like that, they do not contain the toxin. And so they build up the toxin in their body from the insects and store it for long periods. This is why it's even more confusing that they don't kill themselves with it. It's not like they are producing the toxin. They are ingesting it and somehow not dying from it but maintaining it so that if some other animal tries to eat it, that animal will die. So how are they not getting paralyzed? So these toxins cause paralysis and cardiac arrest by binding to voltage gated sodium channels. And so that is what mediates electrical impulses and neurons, muscles in the heart. So it just shuts down your neurons essentially, not good. Yeah, you're not gonna send any more electrical signals and your heart stops and that, yeah, death. Very much death. And so it was for a long time assumed with a hope that someday there would be scientific proof that these animals evolved vitrego toxin resistant sodium channels. But there have not yet to date been any functional studies of poison frogs or the poisonous birds with sodium channels or sorry, with even studying their sodium channels themselves. So whether they can rely on changes in their channels or they have alternate resistance mechanisms unclear. They have yet been unable to study these sodium channels. So in this new study, they set out to do just that. They wanted to see what was happening in the sodium channels when exposed to this vitrego toxin. They compared the effects of vitrego toxin with Saxa toxin, a well-known paralytic shellfish toxin. And it suggests that these poisonous bird and frog species, they don't have functional resistance in these sodium channels. It looks like they actually have a way of holding these toxins in reserve to prevent them from going anywhere near the sodium channels. The frog sodium channels were sensitive to vitrego toxin levels more than 10 times below what is currently present in those teeny tiny frogs. So a 10th of the amount they're carrying in their body was shown in the lab to shut down their sodium channels. So that means there's something else going on. And so this observation challenges the idea that there's some sort of mutation in the sodium channel to resist the effect of the toxins. So this new proposal is that it's all about sponges. They have an alternative auto-resistance mechanism, aka a sponge. Basically it's a sponge protein that they say mops up but really kind of absorbs and holds the toxins to stop them from binding to the sodium channels. So although this vitrego toxin binds to the isolated frog sodium channels, if they inject it into a living poison frog, no effect. So they don't, this is the leap of faith though. They don't yet have any proteins isolated or identified that would be capable of this, but there is something analogous in bullfrogs. Bullfrogs produce a protein that can bind to related poisons. So they've seen something kind of similar in bullfrogs, not at the same level of poison, not the exact same type, but similar ish structure. So they think it's a possibility and, you know, frogs, since it is another frog, there could be a kind of an evolutionary origin to this potentially. And so essentially they've kind of disproved this earlier assumption that there was this mutation and now they are moving in this direction of finding out where is it hiding? Where is it being stored? How is it being stored? How is it being prevented from going at the sodium channels? That's so fascinating. Out again. It's on the skin? Like where is the toxin? Like how do you interact with it? How does it zap stuff? Is it somewhere? How does it zap stuff? You eat it. Oh, so it's just. Yeah. It's in the tissues of the frog. Yeah. Okay. Yeah. That's like the whole urban myth about licking toads, that's where this comes from. You're basically dosing yourself with toxins. So. Yeah, but I mean, like. But on some frogs, they're excreting a toxin that can be hallucinogenic or psychoactive. This frog is just. Poison. These frogs are poison. They, yes. Yes, it's extremely strong. What was the scientific name again? Something terrible-less? Terrible-less, yeah. And that is why. Yes. So terrible yellow frog. We've never really known how this all works. Of course, if scientists can figure out exactly how they are storing and preventing the activation of the toxin going at these sodium ion channels, that could potentially lead to new discoveries of antidotes against various toxic agents because anything that attacks these sodium ion channels, which is a lot of things that we have to worry about as living things. This could help potentially with treatment for that and prevention. I think that they actually had found a molecule or that they had some kind of sponge target. I mean, it is, like you said, a leap of faith in the logic. It's like, well, we don't have this and we don't, we have this, we don't have this and they've put it together and it's like, well, there's got to be something in there doing something, but they just don't know what it is. Maybe it's a sponge, but maybe, yeah, maybe it grabs onto whatever the vitreco toxin, but maybe there's something else going on. Who knows? If we find out, I will report on this show. Very interesting. Thank you very much. Yeah. Thank you very much. And thank you all of you for listening to This Week in Science. Have you checked out our Zazzle store lately? Over there, we have some great t-shirts and lumbar pillows, throw pillows for your couch. We have beach towels, twist beach towels. There's some really cool stuff. Click the Zazzle link at twist.org and shop to your heart's content and support twists while you do it. Hey, Justin, do you have any stories? Yeah, so the Matrix. Do you remember the plot of the Matrix? It's one of my favorite movies. Okay, okay, so you know what the aliens or whatever, the agents, you know what, when Neo comes out of the goo? They're robots, yes. Well, when Neo comes out of the goo, he was plugged in and he gets unplugged and then there's tens of thousands of millions of humans in these little pods. Why are they there? Batteries. Exactly. Ridiculous. Humans are terrible batteries. We're energy wasteers. We're so energy inefficient, yes. So this was changed by the production company. The original pitch and story was that they were part of a neural network and that the aliens or whatever were harvesting human brain computing power. Isn't that a better story? That makes a lot more sense, actually. But I don't exactly remember, but I think when the Matrix came out, it might have been also when AOL was debuting. Like it might have been like, you know, internet, yeah, people won't understand what you're talking about. Interconnect brain. Anyway, they're doing it. Oh, so this is a new study showing that artificial intelligence networks based on human brain connectivity can perform cognitive tasks more efficiently. They basically did a bunch of examinee of MRI data from a large open science repository.  Then they applied it to two artificial neural networks known as AN.  The team of researchers from the neuro, Montreal Neurological Institute Hospital and the Kibyak Artificial Intelligence Institute trained the AN to perform cognitive memory tasks and observed how it worked to complete assignments. They found that ANs with human brain connectivity models, known as neuromorphic neural networks, performed cognitive memory tasks more flexibly and efficiently than other benchmark architectures. The neuromorphic neural networks were able to use the same underlying architecture to support a wide range of learning capacities across multiple contexts. And so this is one of those things that whenever we've talked about deep learning or these, you know, these new AIs, that machine learning systems, they're still 100% based on the input that humans have given to them. In terms of learning, they're not great. In terms of sorting massive amounts of data, they're fantastic. But in terms of adding anything substantive that hasn't been given to it, they're not that great. They're not great at reaching in. But they're learning. But are they? Are they just different? This is a system, this is a system that's using human brain architecture to actually do some learning. Anyway, I thought it was fascinating. I like the influence here on this study using structure leading to function. And that's one of the statements in biology. It's structure leads to function. Function will help us understand why the architecture, the structure is the way that it is. And so by modeling our neural networks on brain architecture, this makes this structure beget function kind of systemically work. And then from the other side of it, I've seen some other news that these neuromorphic neural networks that are also challenged by resource availability and by the networks that they're in so that it's not just easy sailing all the time, where there's actually some difficulties and there are some critical limits to how they function. Similar to the human brain, they function more like the human brain. So there are a lot of researchers who are kind of really taking the modeling of these neural networks from human brains very seriously. Will we make a mini-me, maybe? And then eventually the AI is gonna be like, I need more computing power. I'm gonna put all the humans into pods. And put them in a dream land and harvest their brain computing power. Not battery power. Matrix editing the writers, editing the creatives. Stop it. Just go with what you purchased this year. Just let them do it. You handle the marketing and the money. Last story I've got tonight. Potential new treatment for mast cell tumors, mast cell cancers. They found a way of reducing the number of mast cells by mutating messenger RNA before it delivers instructions for manufacturing the gene that is responsible for cell proliferation. Basically what they did is they kind of made like a fake mRNA that was just off by enough that it would still transcribe, still try to make the protein, but it wouldn't be quite the right configuration. And so wouldn't operate as, it wouldn't initiate more growth within the mast cells. This is, this is still not a thing that they're going to probably put in humans anytime soon. But this is something that like, this is like the number one, I think we're one of the highest killers of pets. Like if you have an old dog or an old cat, mast cell tumors start showing up at some point. Oh really? So I think it's one of those things that like, there is, there's a model out there where we could put this in the hands of veterinarians in some way and let them test it on pets. Like this is actually how we got hip replacements. We got hip replacements surgeries that are so amazing through Labrador Retrievers, right? In black labs, they have just horrible hip problems earlier than most dogs, right? This is usually what takes them out before anything else. And so they started the medical research side, started doing these free hip replacements on Labrador's.  But great, that's awesome for the hip replacement, but for these mast cell tumors, so this really, but this really worked in the mice. They were able to really reduce the size of the tumors. Were they able to stop them? Reduce the size of the tumors. They were the cessation of growth. I mean, it was, it was a pretty, I mean, like it's, what they're calling it, is they're calling it frameshifting by using this mRNA, going in there and basically attacking the mechanism that signals growth. Right, so there's a genetic signal, there's a genetic signal in the tumor that's like, grow, grow, grow, blah, blah, blah. And then this mRNA comes in and goes, nope, you should stop that. Looks like the thing, looks like the thing that's supposed to be there. Yeah. But then is making like, it's almost, it almost reminds me a little bit of a gene drive to an extent, but it's not that, no, I shouldn't have said that. That's not what it is. It's gene therapy, for sure. It's gene therapy. But it's fooling the mechanism into treating it like it's the real thing, and then it goes into action and it can't operate. And so there's no signal to grow. One of the things about cancers is that they're, what they actually lack is being able to accept the signal to stop growing. They don't get the signal for apoptosis. They don't get that signal, which is sent by surrounding cells.  But what they keep getting is the grow, grow, grow signals, those ones still keep coming in. If you shut those down so they're not getting that signal to grow anymore, they stop spreading. They stop producing more of these new muscles. And those cells are fine if you have them in the right numbers. That's not true. So I think that the question is, how do you get the gene in there? How do you do the gene splicing? One thing in a rodent model, but how do you do this in people? If you're going to address it, can we use the maniacs? Can we use the magnetic maniacs? That'd be great. Yeah, just send those in there. Yeah, how do you actually target those tumors and then do the gene therapy that needs to be done? So those are the actual... So the thing is, I don't know that you couldn't do along the lines of the mRNA vaccines that we've all had shot into our arc. Right, could that work? Because if you've been off to the pathologist who has said, okay, here's the proliferating gene cell type that is causing this issue. And you have done the research or someone has done the research that tells you how that is signaled, how that proliferation of that type of cell is signaled. Then you can actually just sort of insert for some period of time the messenger that is blocking the signal. The messenger that doesn't have the right information when it gets to, you know. Yep. Like a messenger has arrived. Oh, I wonder if he has a message. Stop growing. I don't, I forgot. They said some stuff and it sounded important, but there was a long trip, you know. A lot of stuff happened. It was actually kind of grew as a human being. But I can't remember what it was. That's basically the... Yeah, I don't know, stuff like mRNA stuff is going to, it's gone to explode. We are gonna see so many therapies, vaccines. I've just, it's exciting. I, yeah, using mRNA to target various things. That's going to be interesting to watch that develop. All right, I've got a couple of stories for the end of our show. You wanna talk about something? Yeah, yeah, what though? Are we talking about that? Yeah, we're doing this podcast together and we're talking together. It's like, I'm like, hey, let's talk about this. And then you guys are like, okay, let's talk about this. You know, and then at the end of the show and our listeners are like, okay, I wanna listen to this. Great, we're all doing this communication thing together. And then at a certain point, I'm like, hey, did we finish the show? And you guys are like, yep, we did it. We did all that stuff. And then listeners are like, okay, it's the end of the show and we know what's going on. We communicate this whole process of starting some joint process together and then we communicate the end of that. We enter into an agreement and we exit through an agreement that it's done. And it turns out that apes, surprise, surprise, bonobos and chimpanzees, just like humans start and end their social interactions in very similar ways. A study published in the journal I Science, researchers documented apes using signals to start and end their interactions. They're not just random interactions. The apes don't just go grooming each other willy-nilly without cooperation. This is something that is entered into as an agreement. Adults don't play with the kids just whenever they want to, no, the kids and the adults gotta work on that together. So these researchers led by Raffaella Hussain, post-doctoral researcher at Durham University and United Kingdom, she says that this ability to be able to achieve things that are bigger than can be achieved by a single individual alone is suggested to be at the heart of human nature. And part of this, sharing the intentions and working together, joint commitment to things is something that has been thought to be just a human trait. Nope, not just a human trait. It goes up our family tree quite a ways. Yeah, what is it ever, really? That's pretty handy thing though, isn't it? Letting somebody know, all right, well, be seeing ya. You know, like, I'm done talking. Let's move on to other things now. You know what this made me think of was walking the dog, and two dogs come up to each other and they start sniffing each other's butts and they're circling around and it never feels totally in sync when they're done to me.  So one dog decides they're done before the other. It's not often a mutual decision, I feel like. It's not, yeah, not completely a mutual decision, but there is part of it when they do actually go past just that greeting of moving on to play, like you're at the dog park and the dogs decide they're gonna run together or they're gonna all do something together. But then at some point, your dog decides they're done and your dog is just gonna come back to you. And that is something that is the other dogs realize your dog is no longer playing with them. They have made behavioral, probably these dogs, I don't know about this being tested in dogs, it probably should be, but in chimpanzees and more specifically, bonobos actually, these kinds of intention to begin and intention to exit behaviors were very apparent in these different species. Yeah, what they did find with that was very interesting. They looked at 1,242 interactions between bonobos and chimpanzees in zoos. They found that apes did gaze and communicate with each other to start and end these interactions. Bonobos exchanged entry and mutual gaze prior to playing 90% of the time chimps 69% of the time. Exit phases were more common with 92% of the bonobos and 86% of chimpanzees involving these exits. So there are a number of different behaviors that are involved, but it's very interesting as well considering the social differences between bonobos and chimpanzees that they had these differences in the percentage of initiating and exiting and that the initiation was often, more often bonobo, mutual, but less often the chimpanzee being mutual. But chimpanzees were better at mutually going, okay, we're both done now. Just very interesting considering the different level, their hierarchies and how they work together. Hey, Blair, you worked at a zoo. I did. How often do you catch the animals communicating with each other? Oh, constantly. I mean, if they're in exhibits together. Well, no, but I mean like... Like the giraffes talking to the dolphins. Yeah, I don't know what the giraffes talk about. I feel like the lions never look at each other, but that's probably not true. Oh, they certainly do. Yeah. They want to eat you. Well, and you also have to remember that in terms of verbal communication, our ears are terrible. So I remember really early in my intern days, we had a story about how giraffes have whole, like they have a whole language and we've just, we've never heard it. So we've never really thought about it. But yeah, there's a huge amount of verbal communication happening, but the body language is intense. So one of my favorites is that bearded dragons, little lizards will wave at each other. And that's not a friendly wave. It's actually a, hey, hey, this is my space. Down my space. Do you see me? Down my space. This is my space. This is my, this is this dragon's space. Stay away. But what would that bearded dragon do with a hammer if it was given a hammer? Purely nothing. Right, nothing. And an orangutan, what would orangutan do? Something. Right, but how would that orangutan know to do something with that hammer? Observation. Would it have learned it from another orangutan? Or would it just play with the hammer itself? Yeah, I guess it depends. It depends if they've seen another orangutan use it and or what age they were when they saw it and or what their relationship to the other one was. Yeah, so another study out this week, very interesting primate behavior orangutans don't need to have observed other orangutans using a hammer to use a hammer. And this is a question that the researchers thought interesting because, well, the question they thought was interesting was that whether this kind of behavior has to be learned or whether it would continue within the apes if say there were some kind of population trouble. Maybe populations were split up and one group didn't have the hammer behavior and another did. Would the hammer behavior ever arise again? And this study suggests that there is a curiosity and playfulness but also tool use just generally inherently in young animals. In their study of a small group of orangutans at German zoos, they saw that some larger, older orangutans didn't even bother with the hammer. They just cracked the nuts themselves but the younger orangutans were more likely to pick up the hammer and use it to crack nuts. So could also be a youth versus age curiosity. Early adopters, handheld devices. Yeah. I don't know. I thought the kids would pick it up first. Yeah, so the kids could pick it up. But not everybody, you know, the orangutans maybe didn't have to pick stuff up but apparently mice, little female mice need to learn how to be a mom from other moms.  And they found that this is all mediated by oxytocin. So these researchers at NYU Grossman School of Medicine published this study in Nature this week, what they call a never before seen behavior where mouse mothers shepherd these new mouse mothers would without prompting shepherd virgin female mice into the family's nest along with their pups. The virgins began mimicking the maternal behavior of gathering the mom's pups into the nest. And as I said, these virgin mice only viewed this through a window. They would start doing the behavior. If they blocked oxytocin, the behavior was not picked up. And so it's one of the ways that we know that oxytocin is not just a hormone for love and bonding but also behaviors that are related to parental care. And that to be a good mom, at least for a mouse, oxytocin needs to be present but also the occasion to learn from another mom. It's pretty fun. Yeah. That's awesome. You will teach the children well, shepherd the babies into the nest and the babies will learn to shepherd other babies into the nest. That is a video that we put up. It is a mouse straying from the little detritus pile. And the big mouse coming in. This way, come on home. What are you doing out here? Get back, get back in there. Oh my gosh. Like pulling by the tail, like, hey. Hey, get back inside. Get back inside. What are you doing out there?  Don't ride your bike in the street today. Mom-iness, mom-iness, oxytocin, it's important for parenting, complex social networking activities. It's very important. Have we done it? Have we make it to the end of the show? You have done it? Oh, we might have. Is it really that time? It is. I think we have. Then we've made it to that time when we're all done with all the stories and it's just time to say thank you. Thank you for joining us for another episode. We do hope that you enjoyed it. 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So everybody listen to what I say. I use the scientific method for all that it's worth. And I'll broadcast my opinion all of Week in Science. This Week in Science. This Week in Science. Science, science, science. This Week in Science. This Week in Science. This Week in Science. Science, science, science. I've got one disclaimer and it shouldn't be news. That what I say may not represent your views, but I've done the calculations and I've got a plan. If you listen to the science, you may just get understand. That we're not trying to threaten your philosophy, we're just trying to. So everybody listen to Week in Science. This Week in Science. This Week in Science. Science, science, science. This Week in Science. This Week in Science. This Week in Science. Science, science, science. A laundry list of items I want to address. From stopping global hunger to dredging Loch Ness. I'm trying to promote more rational thought. And I'll try to answer any question you've got. So how can I ever see the changes I seek when I can only set up shop one hour? This Week in Science. This Week in Science. Science, science, science. This Week in Science. Science, science, science. Science, science, science. This Week in Science. Science, science, science. This Week in Science. That is the end of the show. We are in the after show. Justin is somewhere I do not know where- What's up Blair? Nothing. these great comments that I can show on the bottom of the screen. It's fun to be able to show what you say in the chats. Share things. Maybe if I decide I'm not going to share everything. Oh, you're sitting down now. I see. Yes. Yes. The time has come for a nice sit. Oh, Justin is fine. He is doing whatever he does at the end of every show. Runs up. Ominous. He'll be back again. But he said, what time did he say he woke up? 3.30? Yeah. Up to since 3.30. Yeah, that's no good. That is no good at all. It's early. My regular wake-up time is 5 now, so. 5. I don't understand it.  But why? Well, I also start working an hour earlier now. And I have to drive to work now. You have to drive. Yeah. I started an hour earlier and I have a 45-minute commute. So push this things back considerably. Yeah, well. Back to commuting. Yeah. Let's see. Is Kai's school reopening? Yes. Yes. Kai's school is reopening. Portland Public Schools is going full bore straight ahead with opening up full, full class sizes. I don't know what I'm gonna do. I don't know what we're gonna do yet. I don't know that I am convinced that it'll be safe enough with, you know, 20 plus kids in a class. And yeah, I'm not convinced this is a good situation. So. Well, tell me why. 3 p.m. in Australia. Nice work, Daniel Smith. Aaron Lohr woke up at 5 in the evening. Oh yes, Paul Disney. Yeah, this is something that we didn't talk about, but it is right now the Perseid meteor showers. So if you're up and the sun isn't up yet, Blair, perhaps if it's not foggy in the Bay Area. It'll be foggy. Yeah. If you have clear skies, some meteor watching might be in order. Yeah. Absolutely. Yeah, I've never, I don't think I've ever successfully seen it because of that, because of the fog. That was, that's one of the things like here in Portland, maybe we'll be able, we have so much light pollution in town, though. So you have to get up and leave town to be able to see anything. I think Neil deGrasse Tyson said the first time he'd ever seen the stars was at the Exploratorium in the Natural History Museum in New York, where he is now the head of, right? Yeah. Because the light pollution just made it impossible, and probably a combination of that and weather. Can't look up at the sky.  Yeah. All of the top buildings. So many of them. It's really impressive what they've done there. But they can't see the stars. Yeah, this is the time of year. In youth, in my youth days, I would go out with a bunch of friends, throw down some blankets out in the middle of some farmers field and just watch the show. Yeah. Davis is wonderful because it is so rural. It's grown a lot recently, but it's still in the middle. Oh, it's, yeah, you do not have to take it. It's not farms and fields. Yeah, you don't have to, you can ride your bike out to get away from the light to be able to see stuff if you want to. Yeah. Yeah, Davis is great for that. And in the central valley, you don't get those, the cloud cover in the summertime that other places do. No, and thankfully the smoke is cleared. Yes, for a minute. This, by the way, this ginormous fire is taking place in my childhood wilderness wonderland. Oh, no. Where, yeah, where I got to wander around in the woods and had, we had, we were caretaking a ranch, 800 acre ranch out there, which is the other thing that nobody's talking about. It's like, ah, it's like a few thousand people who had to move the town of Taylorsville. It was right near there. We were like half a day's horse ride from Taylorsville, which I'm not sure how far that is. It might be like six miles, something like that. This is how, this is how rural we were living. We had all these horses from the beer of land management, these wild mustangs that they were going to call in Nevada. And they were just giving them away. My uncle took like seven of them. But there's cattle. That's cattle country up there. There's cattle all over the place. So we were talking about these people who got evacuated. I don't know where all these cows went. They could not have gotten away. That, yeah, that's one of the huge issues.  But yeah, I mean, not just wildlife, but our ranching life. But thousands and thousands, probably, I don't know, I would just be making up numbers, but there's definitely a magnitude more cattle than there are humans. People, yeah. And yeah, people aren't really talking about that. And yeah, how do you get them out for sure? I mean, the cows don't want to be near the fire. So they're probably moving themselves. Although I hadn't looked, I hadn't looked at the region in decades. Turns out there was a town, Taylor'sville, again, that was the half a day's ride, that had a population of 15. When I was, like, the mayor, mayor's wife was the sheriff and they both worked at the post office and they, like, it was like, it had a general store, which they probably aren't. It might have just been them living there, their family. But it has grown, it's 10 times bigger now than it was then. So there's 150 people? No, there were 30, 40, 40 something years ago. Yeah, it's really blown up in those years. It's in a very rural part of California, and it's a gorgeous, gorgeous area. And that was a place that at night, when you looked up at the stars there, forget going out into the farm fields, outskirts of little town of Davis. You saw what, you saw the wheel upon wheel of, you saw everything. I mean, it was, that is the most incredible sky at night I have ever seen. I've never seen anything else that has ever come close to it because there are no lights. Yeah, the Rocky Mountains, the Rocky Mountains, Colorado, there's a lot of sky up there. A lot of sky. It's pretty amazing. Yeah, but we really do have to get away from people to be able to get a good view of space. And now we've got all the other stuff that we're putting up in space, billboards.  Do you remember that this was my, this is my CubeSat idea. This was my idea from a, like, I don't know how long ago that was. We were talking about like what it would take for Twist to launch a CubeSat. I was like, we need a camera that points at the thing that has a little scroll on it, that you could have the planet Earth in the background. This is, he's stealing my idea from 20 years ago that I never used. But still, it came up with the first Elon, so you know. You should have patented it. I did, I had not got a patented idea to be shared. Just somebody can just go do it better. That's all you need to do. Blair, you're frowning. Yeah, she's reading. That's her reading face. Yeah, yeah. Reading, frowny reading face. I have, mine's worse. You're reading through the chat. Mine's like this. Everybody's pretty reading faces. I don't know what happens. I don't know what happens. But my, the whole lower jaw just goes slack. I'm like. Yeah. Oh my goodness. Nature. Yeah, right now we've got super hot temperatures. We've got a heat wave going on and luckily we don't have a lot of smoke here, but I know there is smoke and fire in other places. And the hospitals are filling up from COVID Delta variant. So as we go into the hottest part of the season, we're going to be up against a lot of health issues related to heat and overheating and yeah, things are going to be coming to a head here in, in the United States in just a bit. Daniel Smith in the chat room saying, never thought about the effect of the massive fires, floods on wildlife down here in Australia, though I know paradoxically the trees love fire down here. Yeah, actually all you need to do is look at Tasmania. There are, they have the same trees in Tasmania that they have in Australia, but they are some of the tallest trees in the world. And it's because it's, it's a tree that never stops growing. Just in Australia proper because it's just, they burn everyone so on. That's how they reproduce. They need a fire to reproduce. But down in Tasmania, the little tiny island south of Australia, those same trees are in a rainforest condition. They don't have fires. They haven't had a fire in 400 years. And those trees are 400 years tall. They're like, I don't know if they're taller than the tallest sequoia. Oh yeah, those are some big old trees. Yeah. Yeah, but, but similarly, like they're up there. They're like, if they, if they're not the tallest, they're second only to the sequoia. Yeah, but not all, I mean, wildlife is one issue. A lot of animals die in fires, but then as you were bringing up the ranch wildlife, like I know people who own horses and whenever they're down in the LA area and they're out in a rural area, but whenever there are fires down there, they're like, I have to evacuate my horses and my dogs and my birds and try to get everybody out. If you have more than one or two trailers that you got, it's impossible, basically. Yeah.  Like running from fires, like it gets in, it can just, it's just a horrific scene. Are we in El Niño, La Niña? No, we're in a drought. We are always in like, I guess, the, yeah, the ebb or the flow. I don't think we are in an El Niño or La Niña year this year, but we're kind of in between them. But there's some. We're in a drought. I think, isn't there that California was in a wet season when the Spanish first started exploring it? Yeah. It's like been a couple hundred year wet season, and it's actually normally more drought-like conditions anyway, which is just being, we're getting back there very quickly instead of over slow progressions of time. Yeah, really fast. But one, one of the things that you can, you can look at is native wildflower, native wildflowers in California are more fire resistant than flowers elsewhere. They tap their, they have tap roots that go deeper than non-California native fauna because they are, or flora, because they, because they're, They need to, they know they need to find the water. They know to go deeper. They already know you're not going to get on the surface and they have better dormant periods for drought. Like poppies can, you can have a couple of seasons without rain. These poppy seeds are out there. Just the California poppy is dispersed out there. Finally, a few years later, you get rain and they will just show up and like nothing ever happened. Like they didn't miss a season. Yeah. But they have to get rain at some point, which is where we're failing them currently. Yeah. But it might not be out of their range yet. It's going to be the non-native plants that are really going to suffer, which is like everything that we grow on every farm, everywhere and everything that's in everybody's front lawn and everything that's in everybody's garden. Well, except the other piece though, is that the non-natives burn harder and hotter. And so you might have fires surrounded by plants that burn hard and hot. Then it might not be so easy for them. Yeah. The other thing is the native indigenous peoples of California did control burning. And it was a thing that once there was governance in California by the United States or the state of California, they started forcing them to stop doing it. Mm-hmm. Didn't ask why you're doing this. How is this a thing? Can we learn why the people who've been living here for, I don't know, maybe 20,000 years have controlled burns? What are you doing that for? What's that about? No, just stop. Just stop. That was, that was, uh, there's, there's a knowledge of- And now we have massive fires because we didn't manage everything appropriately. There's a knowledge of biomecology and conservation, or at least symbiosis that you can get from an indigenous population that is, is something that with all of our observations, with a few hundred years of looking at California, we're just starting to figure out why that's a good idea. Oh, come on. Don't new immigrants to an area, always, you always know, know better. Come in and say, I know how to do it better. Stop your immigrant fashion. I'm a new American. It's also frustrating because, you know, if we had, if we hadn't pushed the native peoples out of natural lands, we wouldn't be spending all this time and money and resources to try to figure out how to manage it properly now ourselves. And by pushed, I mean, that's a very soft word. Let's, let's use the- Kicked, shoved and stole? Is that a- Genocide, actually genocide. Genocide is the actual appropriate word. Genocide is, is what took place. Yeah. Yeah. And we are reaping the, a lot of the downsides of all of our past misbehaviors and crimes. And just misunderstandings and hubris and- And chemical warfare when we gave people blankets laced with polios so that they would die. Hubris, oh gosh. No, it was genocide. It's just like, I wish people would just stop ever- I'm talking about the hubris of thinking that we, that, that, you know, coming in- Oh, that, yeah, we knew better. Yeah. We knew better. We know how to manage this. We can take care of this land. It's fine. I'm from Ireland. What are you doing? We don't burn anything in Ireland. Ireland is a moist sponge of an island. You don't have- It's like, ah, we don't do this- We can grow potatoes. Yeah, we're covered in fog all the time, you know? Potatoes. That's what I know how to- Yeah. I'm from the Netherlands. Let me tell you, we've never had a forest fire. Yeah, you're half underwater. Stop. But you're talking about all my peoples here. Yeah, well, I just, yeah, I have a lot of those people as well. But I know how to manage forests. I have a lot of those peoples as well. But it's, yeah, you know, whenever the invasive species shows up, it's like, I'll just put my seeds down everywhere. Everything will be fine.  It's actually seasonal. It's called summer here. It's seasonal, but IPCC report, these kinds of things are going to get worse. The only thing I saw that was- More and badder. More and badder. Not gooder. Only thing that I saw. Out of the IPCC that wasn't kind of like, it's kind of what we kind of just knew before. And it is a thing we knew before, but it's happening. They're seeing evidence of the slowing of the Atlantic conveyor belt. Yeah. Yep. This- But they said it's not going to turn into the day after tomorrow. It's not going to turn into the disaster movie where they're like, it's going to, things are going to change, but it's not that, it's going to be that, not going to be that extreme.  I think he's out of the University of Copenhagen now. Jason Box. All right. I still want to get on the show someday. He was explaining that one of the interesting things about sea level rise is that it won't happen to the Scandinavian countries and a lot of the northern Arctic countries. So probably also maybe not the southern as well, because there is so much weight in the ice that when it melts, the earth will actually rise in elevation. It'll, it'll, it'll put it like, because it's got pressure on it. When that pressure is released, the earth in a large part of the Arctic circle will actually rise. Maybe not more than the waters, but it'll, you know, it'll make it so that there's not significant change. What will change significantly and even probably therefore more than more than the reported sea level rise, because this whole effect is still not in the IPCC. Is the equatorial regions will rise much faster, which is, Are you sure they're not? I mean, they looked at 14,000 studies. And if they're talking about sea level rise and they're talking about, I mean, they do, they absolutely, this is, these are, there are studies that have been done. So they know that ice weighs down land. When you remove that weight, it's going to move up, but they're also, they're calculating the water going into the oceans. They're also trying to calculate the, the thermal expansion of the water. So they're definitely, it's not going to be completely homogenous around the entire globe. It's going to be different in different places. So if they do have that data, I didn't see it shared. So if they did share the disproportionate effect on what is mostly what we would call the third world nations in Florida, you know, same thing. I haven't seen that in a report. I haven't seen the report expressing how much more it's going to affect sea level rise on equatorial nations. I haven't seen that anywhere in there. But that's also to say that with all the science scientists that they have involved in all of the things that they have addressed and looked at at this point, there's still a ton more data that feeds into this system that is unaccounted for, as has been every iteration of the IPC report, we keep adding to this knowledge base and, and then we're going to watch, we're going to stop predicting and get to the point where we kind of are already now where we're doing observational reporting on, on these effects. Iron lore. Oh my goodness. Iron lore is asking if the ice caps melt, can we get access to all that hidden fossil fuel? And if so, how much cheaper will our stuff be? So that's part of the problem. Yes, if the ice caps, if the Arctic becomes completely open, yeah, there's, there's a ton of gas and oil underneath there. The U.S. and Russia are, we, there's going to be conflicts because of it. There already is. I think, you know, we're like trying to stick our flags on the bottom of the ocean right now. Staking claim to these gas and mineral reserves. But yeah, yes, it would be easy to access ish, that's under the ocean. So not that easy to access, but, but not good, not good at all to continue to heat the planet. So no, we just, we need to tell the gas and oil companies, no, you can't go there. So you've got fossil fuel alone. So this is sort of, I, I joked about this in a disclaimer about the fact that the fossil fuel industry, nobody will ever be held accountable. No corporation, no individuals, nobody who knew but still acted in the interest of profit over entire well-being of humanity will ever face consequences. No, because we have a capitalistic society and they were just doing what capitalism was telling them to do. Nobody in the tobacco industry. Go forth and prosper. Nobody in the tobacco industry ever went to jail. Leaving destruction and death in your wake. If you can, you should. Hundreds of thousands of people being dead, right? But now we're here in real time. We're here in real time. I, I think, I think you should, I think you should compare the death toll in Florida to a comparable state and make a charge of manslaughter at the very least on that many cases to the, to, uh, uh, death, uh, what's his name? What's the Florida guy? Death Santos? Florida man. We're just going to call him Florida man. Florida man. I think we should charge Governor Florida man with, uh, you know, tens of thousands of cases of manslaughter. Because that's what, what he's doing is amounting to that. And also the, uh, Abbott and Texas. Like, just, they are willfully, and I, and I'm telling you, Republicans do things with a motive. That's all politicians do. All politicians do. But, but the Republican Party is really important. All politicians do things with a motive. And as long as there's money in politics and politicians. Are able, after they're in office to invest without like insider trading conflict of interest. Like come on man. And they've got the lobbyists who are like, give me, I'll give you the money if you do this for me. And then suddenly you have millions of dollars going back into the, into the pockets of. Yeah. But Senator Republican, the Republican Party has sort of branded itself. Just the five dollars. As the corporate front for a lot of things. Big oil has been one of their sponsors for many, many, many years. Yeah. Big tobacco before that was, was the thing too. Who is sponsoring these politicians through this COVID? Or, or, or at the very least, not backing away. Not telling them, because of what you're doing, we're withholding funds. I feel like there has to be a profit margin somewhere. No, there was, somebody suggested that the, the lack of, the lack of mask mandates for school. There were, there were comments on Twitter that what was happening in Texas, I didn't see related to Florida, but could potentially apply that the, the steps that were being taken to not protect children in the schools could, could possibly be seen as a ploy to help with the dismantling of the public school system because they don't really want a public school system anyway. So. Awesome. Who knows that? So there was, there was a, I mean, no, no proof whatsoever. This was a comment that somebody made on Twitter. It's not like we need a public school system because it's not like we have public understanding that is lacking that is just like currently affecting public health that would prove that you would need a better public schooling system. Yeah. Right. And there's also, there's also the idea that people who want their worker class, their worker caste system to go back to work, know that that worker caste can't afford childcare and needs to put them in school. So they have to. Yeah, that's what I wrote in the chat room earlier. But that still doesn't explain the, that explains opening the schools, but it doesn't explain in a mask. I almost feel like there are, there is an interest that wants this virus to infect and kill more people and there's a profit behind it. There has to be. And the only thing I could think of, and I'm probably just out on it because it's my one thing that I'm always like hyper focused on is housing. Like if we, if we have lost hundreds of, 500,000 people, how many homes is that? And then you have how many foreclosures that are taking place? It's recreating the housing crisis. And the only people who really profited massively, gigantic transfer of wealth from the housing collapse was, was Wall Street. Blackstone is going to, yeah. Blackstone companies like this, but Wall Street. Statistically, the majority of real estate investments. Statistically, the people who died of COVID don't own homes. I'm just going to put out there. So that, that's kind of the problem with that argument. But they're, but they're also, but they're pushing it for a whole sect of people. But yeah, but okay, but so here's the thing. Interesting thing that was found though, actual like people really trying to move things around the report that a Russian, a UK front company for that called itself, it was a marketing company, but it's basically Russian, a front for a Russian organization. Cambridge and LA. Marketing was putting out marketing campaigns that were trying to show that the vaccines, like doing like misinformation can and disinformation campaigns about vaccines. And they recently got caught by Facebook because they were trying to recruit influencers to help them with their misinformation campaigns and the influencers reported them. And so that's the only way that Facebook caught them. And, but it ended up because of the trail, they ended up discovering that this group wasn't only trying to get influencers to help spread misinformation, but had also been, had a whole bunch of accounts and bought accounts that were on all the social media, pushing a bunch of really ridiculous ideas that people were constantly making jokes about, but they were just putting them out there. So yeah, but I mean, there has to be, there has to be anybody who's against people protecting themselves and pushing this has to have an agenda at this point, has to have a payoff for it. Now it can be, it can be an opportunistic because somebody has sold this many dupes on this and I can run off of that as a politician. That's also possible from a political side. Bad press is still press, you know, and people. There's bad press and then there's like people, kids are dying. I know. I'd, yeah, I don't, I don't, I don't understand. As simple as it aggravates and enrages and activates a particular group of people that can also be profited upon. I really think it's that simple is that you are activating a group of people that you can manipulate to further use.  This is why like the home is the biggest thing that can get flipped in any of this.  This is the thing. Most of them are renting. And yes, because the majority of COVID deaths were lower socioeconomic levels. Yeah, but, but you're forgetting this is Florida. The houses are, have been priced at lower socioeconomic levels. So those, there's still a huge barrier to home ownership. 63% or 64% of Americans own their homes, 500,000, 600,000 people. Maybe it's more now are dead. So now you're talking about maybe 300,000 homes, maybe 200,000 homes. So I don't think it's directly, you're, you're assuming it's a direct percentage and it's not if Americans own homes, not a uniform distribution of people died. But you got to look at who is, I mean, there are people who don't vaccinate. I think this is an interesting direction. But I don't think that we have, you know, this is, this is all speculation. And it's just, we're doing it in the after show. Yeah, but it's all speculation. And I mean, if we're going to speculate, I really think it's all a political thing. I really do. I think they're trying to push, you know, and activate a group of people to change over what happens last year. And both views could be correct as well. Because I guess I'm moderating. I mean, there's no reason to think that there might not be multiple bad actors with different driving forces behind them, right? Like there, there could be just the political actors. There could be the ones that are out there trying to make money off of specific things. There could be, there probably are.  That would be a big chunk of money. Yeah, the people who are continuing to push this particular thing. So there is the anti-vax 12. Have you heard about that? Where there are 12 people that have been specifically linked with vaccine, miss and disinformation. Like 12, 12 accounts, 12 people, 12 groups that have been specifically linked. And now it's like, because people are tracing the data, they're able to go back and go, Hey, these 12 people. And when something happens, it's the same exact people. It's the same exact groups that are saying the same exact things over and over again. So the question is, let's go back to those people, find out where their money's coming from. You know, what exactly has happened to keep them? Are they just doing it because they like the attention? Could be. You know? Or they could be, I think, thanks. Yeah. There's an anti-vax, a Canadian anti-vax woman who, she definitely profits off of it for her personal business. And so, yeah. So there's not, there's not, there's sometimes not just the bigger gain, but just individual personal gain too. People are, people are fascinating beasts. I don't like a lot of them. I like a lot of the people who are in our chat room right now, who are watching, who are hanging out with us. I like the people on the screen with me right now. But I gotta go. I was about to do the full 24 and I don't want to. Oh, let's keep you up until 3.30 in the morning. Oh, thank you. Yeah, Lauren. No, I want to stay. Yeah, no conspiracy. I'm trying to stay away from the conspiracies. Even in the after show. We can speculate a little. But I gotta bring it back. Bring it back to the facts. I'm trying to start one of those things where we become the center of a controversy and we can spread information that's really profitable. But we don't have a way to make money though. No, I don't want to, I don't, I would prefer not to get kicked off of social media platforms. So let's, you know, let's make continuing to talk about fact and what we know, science, curiosity. Let's try and keep that going. There's a lot of stuff out there in the world right now, everybody. We're going to help you wade through it, I hope. Say good night, Blair. What do you have to say right now? Yeah. Say good night, Blair. Good night, Justin. Nope, did it wrong. I'm tired. Then say good night, Blair. Say good night, Justin. Good night, Justin. Good night. Whatever you're ready. Good night, Kiki. Good night, everyone. Oh no. Oh no. Everybody's so tired. Blair really needs to go to bed right now, obviously. Go love your Sadie. Don't fall down right there, Blair. Oh, look like you're just going to go. Good night, everyone. Thank you so much for joining us.  Stay sciency until next week. We'll be back with more This Week in Science. Thank you so much for joining us tonight. Bye.