Thank you very much Scott for the very generous welcome and thanks Julia for the invitation to speak. The work I want to talk about is an area that I've been thinking of moving into for a number of years and it's interesting that around the world when we started this I became aware that there's a small number of groups doing exactly the same sort of work that have just begun around the same period as ourselves and I think this comes out of both my intrigue with the mechanisms of illness but I'm also a clinician and the awareness that at the moment we have no way of identifying early individuals who at high risk of developing bipolar unlike the schizophrenia programs and I'll use that as the analogy we can only intervene when people develop clear and robust illness so really the translational aspect of this area of research is that hopefully this work being undertaken around the world will inform early identification and intervention programs so the question really I suppose just put it in other words is what factors determine which children of those with bipolar will go on to develop the condition and who'll be resilient to this and while we're looking here at a very focused and enriched sample a genetically defined sample this also has the potential to influence broader practice about early identification of bipolar disorder and as I was saying before that elucidation of such factors would inform because at the moment it's it's very much guesstimate and clinical intuition about who you intervene early in a seriously considering has bipolar I want to at the beginning go over a number of the aspects of where the genetics is up to and some of the points have already been made by Brian just so we can put in context this very specific high risk strategy that we'll be looking at for those of you that aren't aware like schizophrenia bipolar disorder very strongly genetic disorder most studies show that the heritability is in a range of 80 to 90 percent the those sort of delightful Scandinavian data sets that we all salivate over have has looked at heritability cross populations and shown that first degree relatives of individuals hospitalized with bipolar disorder have 10 to 14 times the population risk of developing the condition so all the epidemiological evidence confirms that this is a very strongly genetic disorder the question in recent years has been what's the mechanism as Brian saying as for schizophrenia the predominant means of inheritance appears to be these common genetic variations you get a critical mass or aggregation of these common variants and you get the illness at the moment we don't know how many as with schizophrenia that appears this is the main mechanism Brian was talking about copy number variants or structural variants the moment it's not clear whether that plays a role in bipolar if it does it's certainly not as common a mechanism as in bipolar you saw this before and I'll just point out the relevance to our story here this is looking at replication of the large international schizophrenia consortium data set and you can see here that Brian pointed out the replication and other schizophrenia data sets including his own but what's striking is the fact that this also replicates in two independent bipolar disorder data set so schizophrenia common gene variant pattern replicating in bipolar but not in other physical disorders like coronary artery disease Crohn's disease hypertension etc so there appears to be from several strands of evidence major sharing between bipolar and schizophrenia the other strand of evidence that's really clarified that story comes again from Scandinavia where they look at population data and the essential story here is that they looked at individuals with a number of hospital diagnoses of bipolar looked at the population data sets how many their relatives had bipolar and as you'd expect higher than population rates but what was striking is when they looked at those relatives they found higher than population rates of schizophrenia they did the opposite they looked at people hospitalized with schizophrenia looked at the first degree relatives as well as fine finding higher rates of schizophrenia there were higher rates of bipolar disorder so this is a graphic from that paper and you can see here these are shared genetic effects as the paper of Lichtenstein that was published in the Lancet about a year and a half ago so that there are there is major sharing in terms of the genetics between the two disorders it's not saying they're the same conditions as some had interpreted in some some of the media discussion you can see there are also unique genetic effects so what we see is that there are shared genetic origins between these two conditions but distinct genetic origins which account for the clinical differences what genes are involved the story here is a little bit behind schizophrenia but catching up very quickly it's interesting that the schizophrenia research community were much better at collaborating than the bipolar disorder community but I think the story is forcing people to come together this was the most recent data presented at the World Congress on psychiatric genetics and Athens late last year numbers are now just staggering I mean these are the biggest studies ever in psychiatric research so 12,000 cases with bipolar predominantly bipolar 152,000 controls and the amongst the loci coming up the two that appear to be the strongest one the calcium channel subunits gene coding for that and also for one of the the genes involved in sodium channel regulation so ion channels are looking an interesting story so it's starting to become apparent what some of the specific genes are as well as this being strongly genetic what about some of our own work and this is also a crowd lot of interest we were invited to contribute to a European consortium the study was only published four weeks ago by Stephen Kitchon from Germany from the Mannheim group and this study demonstrated and associations as a large association study about 9,000 individuals with bipolar about 12 or 13,000 controls and you can see that this gene is really interesting gene for bipolar neurocan is a gene that the protein is a glycoprotein that's involved in cell adhesion and cell migration so very intriguing prospect in terms of abnormalities in neurodevelopment in bipolar disorder and there's a lot of interest in seeing whether this is turning up in schizophrenia as well this was just a methodology there was an initial large German case control study which showed a number of interesting possibilities there was a European replication sample and this held up after the European replication sample the journal asked for further replication so as well as a number of American and English samples were invited to contribute to this and you can see here that once once all these groups are combined that there's still a significant effect here it's 1.2 and as Brian was saying these are small effect genes these are not sort of powerful robust genes in and of themselves we're looking at interplay between these and what also makes this intriguing is that animal work has indicated that it's only expressed in brain which makes it a substantial interest and it's expressed and this is with some of the animal studies involved in this paper indicating it's involved in areas of interest to us in psychiatry for example near cortex near cortex and basal ganglia areas so an interesting one to see with really strong evidence for that as Brian was saying in schizophrenia that despite the growing knowledge that we can only account for about two or three percent of the ideological variance at the moment so the big challenge of the field is what's the nature of the missing heritability as it's being turned the missing or hidden heritability one of the possibilities is that you can't demonstrate the effect when you look at individual genes in isolation but you can demonstrate it when you look at interplays between genes and I'll come later on because one of the other issues is is the part of missing heritability the interaction with the environment and that's actually a much tougher question to answer in many ways so this was a paper we published in biological psychiatry last year the specifics aren't important but the methodology is that now we've got the statistical capacity to look at interplays between genes is very demanding statistically and what we found was that we looked at individual genes on their own that were associated with illness and then we looked at the interplay so this is the chromosomes like a clock the the black bars here are individual genes that came up associated with illness and most of the ones that we demonstrated were actually had been reported by other groups which gave us some confidence there was a validity to the areas that we demonstrated but the grey lines are the significant interactions after statistically correcting for multiple gene interactions so it gets very tough in terms of the level of statistical significance required and you'll see here the number of these are between individual genes that had demonstrable individual effects but you can also see that some of them are with areas that on their own didn't come up that weren't sort of on their own strong enough to be demonstrably associated with illness so we see here that and if you understand this is probably biochemical pathways if you have two pathways hit then the illness becomes apparent at that point so we see here that some genes won't become obvious until you start looking interactions so various levels of complexity but the story is starting to become more obvious in terms of some of these stories so let's get to the main game so we're saying before that I become intrigued about can we demonstrate factors features be they clinical or biological that might alert us that this is an individual who is at particularly high risk of developing bipolar disorder it's a methodology in medicine if we can demonstrate risk factors that has shown its benefit if we look at public health studies for example with cardiovascular disease have been major reductions in in mortality in morbidity with stroke and myocardial infarction by identification of of significant risk factors and early intervention programs and so there's been a major impact when death rates due to stroke have reduced substantially within our community by this methodology so how do we identify what our predictors and risk factors for mental illness with schizophrenia schizophrenia has the the advantage and benefit of having a reasonably well-defined prodrome in bipolar though people talk of prodrome there's really no clear prodrome that's been demonstrated now look at some of the studies so that we're stumbling around in the dark a bit more in terms of current knowledge well what do we know about the psychiatric illness amongst the offspring of people with bipolar disorder I'd give a few of the seminal studies there was a meta-analysis published in the late 1990s looking at rates of illness in the offspring of individuals with bipolar and in those studies they showed that the there were rates amongst the various studies of bipolar sort of ranging from 4% to 15% now most studies show population risk of about just over 1% so we're looking at 4 to 15 times population risk compared to what you'd expect in the control population of 0 to 2% individuals are also almost three times more likely to develop any mental illness and four times more likely to develop an affective disorder and that's bipolar or depression it was a large study published just two years ago by Burma Ha and that was the biggest study that's been undertaken of 388 offspring of individuals with bipolar compared to the offspring of 251 controls and this showed and really confirmed very strongly the increased risk of bipolar disorder in these relatives I found an odds ratio of over 13 mostly bipolar 1 and bipolar NOS has actually been debate about some of the diagnosis of bipolar in that as to how liberal that was even though it appeared to be more DSM based what about following through because to me the there are two essential questions here one is when you get a group of offspring compare them to controls can you demonstrate differences at that point are there any baseline differences so that's the first question for the second question in many ways is probably more interesting one if you follow people over time can you demonstrate or tease out predictors of those who convert to bipolar disorder so let's have a look at the literature that's looked at clinical predictors of outcome because to this point in time there've been no studies that have involved biological markers one of the larger studies was undertaken Stony Brook the Stony Brook high-risk high-risk project in New York and they followed 134 kids over time and found it compared to controls there were higher rates of a range of disorders and I think this is an interesting story we'll come back to when we look at some of our own data that they had more behavioral attention or problems and more psychopathology in general however the question that came out of this is how specific are these findings to families with bipolar disorders when they looked at the offspring of those with other disorders like schizophrenia and depression there were no major differences between the groups there may be some non-specific effect of growing up in a family with illness another study that looked at neuropsychological predictors study of Maya and followed up a relatively small sample but over a long period of time and found that those with abnormalities in executive function the Wisconsin card sort test predicted they were the group that were at much higher risk of developing bipolar disorder Janice Aiglin some of you would have come across her name Janice was the first author in the first molecular linkage study of bipolar back in the late 1980s it was interesting as it was that study that really inspired me to get involved in genetics research didn't realize the story would have gone on this long since then since the late 1980s but she looked in the Amish population and followed up children of the Amish who developed bipolar and found a sort of broad pattern of abnormalities that were more common than in those with the control families that they had more mood, lability, low energy, anxiety, a number of attentional problems and school difficulties they didn't follow through to conversion and that study like most didn't have an illness control group most studies don't I think that's a limitation that's there for a number of these. So where's the field up to at the moment? We started our study about 18 months ago when I got involved in this was discussing with some US colleagues who said well look there's a similar study that's just started across the US and we've eventually agreed to collaborate so now we're sort of inactive collaboration and share much of our data set with that sample. So that's the study being led by John Nernberg of Indiana John very long track record in genetics of bipolar and other disorders. There's our group we're looking at 12 to 30 year olds. There's a Canadian group that's published in clinical work and Duffy. There's a Scottish group and I'll I'll show some preliminary findings from the Scottish group because I'll talk about some of our imaging results and also talk about some very recent results coming out of Andrew Macintosh's group from Edinburgh. Michael Bauer's group in Germany are looking at cognitive therapy as a means of preventing the development of bipolar. So rather than looking at prospective features they're going straight into a randomized prevention trial. So we're collaborating with the US group between us we're sharing our data set for the 12 to 21 year olds. One of the big issues here is numbers particularly when you're looking at predictive capacity for future illness development. So in the joint sample there are now 290 at risk and 170 controls. So this is now a substantial group. We share completely our clinical data set and we got blood for genotyping in these samples. We've contributed about 60 of the 12 to 21 year olds a major contribution to that. But I'll focus on the work we're doing here in Sydney. We've engaged the graphic artists who come up I think with this very catchy logo catch them before they fall and I think that really has captured the essence of what we're on about that really the whole point of this research is to pick up bipolar before we get into the devastation and some of the work that we've seen through I think some Michael Burke's work indicated that the worst outcome in people with more illness. So if we all have this hope and belief I think it's not perhaps as well substantial as we'd like that if you can get in early you can improve outcome. So we went in probably a bit ambitious after 500 but we're aiming for 200. I think that'll be very reasonable by the end of this year as well as control. So we call it the bipolar kids and Sibs study if you see something about that in a minute. So I said the same before there's two components. This one to look at factors at baseline that are different between the two and then to follow up over time to look at what are the factors that predict who converts to bipolar. So very quickly just take you through the method and look at some of the results because I'm aware that time's moving on. We're doing a very detailed assessment. So people come in for a whole day and any of you that are interested the families are very keen on this. I wondered how this would go. But the families the bipolar families really very worried about their kids. So we've flown people into Sydney from all over the east coast of Australia. It's been one of the most expensive studies per capita I've ever done. But our recruitment really has been going very nicely. They come in for a whole day. They have a very detailed clinical assessment. They have a very detailed imaging protocol with structural functional fMRI. I'll talk about those in a minute. We've done DTI diffuse intense imaging and also resting state. We're doing genetics. We had a benefactor approach as recently who's given us money to do epigenetic studies. One of my hypotheses has been that perhaps those at risk of those who have more childhood stress and epigenetics may be a way of getting a handle on the biochemical results of that and also a battery of neuropsychological testing. The moment we've got 105 kids. We've done a complete assessment on 85 controls and we've also brought in a bipolar arm. So there's an illness control arm. These are people with bipolar in this same age group. And at the moment we've followed up over 20 and we've had clinician diagnosis of three. We're chasing those up that appeared to have already converted to bipolar, which is encouraging that we got a sample which is going to convert at an acceptable rate. To demonstrate predictors you've got to have enough converting to the illness. Just to give you a feel for the cohort. So while this isn't earth-shattering it's given us some confidence validity of the sample. So you can see here and this focuses on the 19 to 30 year olds because we've got the best control group for this. That there's a much higher rate of illness. This is lifetime illness and this is not just definite but it's also probable. So that's why the rates might seem a little bit inflated. So you've got to be aware we've used the NIH best estimate criteria and these are the definite and probable. And you can see here that those at risk have six times greater likelihood of having any psychiatric diagnosis as childhood or adulthood illness. This is 19 to 30 year olds. When you look at the rates of affective disorder the odds ratio is 6.9 for those who are offspring. So this is a group with high morbidity and it's very striking when you actually see this happening sort of in your own group. I won't go through this in too much detail. We haven't had anyone as yet I was saying we've had a few clinically diagnosed but at the point of interview had bipolar NOS but the major affective condition you see is depression in these samples much higher rates, strikingly high rates of anxiety disorders and also behavioural disorders. It's a very broad picture of psychopathology. I'll just take you through some very quickly some of the results that are starting to come out. This is work coming out of the US sites on one of the co-authors in this group in this paper and you can see as you would expect that those in the at risk families have an earlier and greater rate of affective disorder particularly depression. What's interesting and starts to give us some hints about clinical presentation is that those and this is only in the bipolar families not in the control families that in those who are developing major affected disorders at the moment that's mainly depression. There are high rates of anxiety disorders so maybe anxiety is a prodrome in these particular families. I want to give you some very brief results from the imaging. We've got here the results for our 19 to 30-year-olds because we've got good comparison group and also this avoids some of the developmental problems when you're looking at adolescents and combining different samples. This work has been mainly undertaken by my post doc Gloria Roberts and Michael Brakespear has been going through the statistics and confirming that. We hypothesised that there were abnormalities or dysfunction in emotional regulation in these families. We thought that was a reasonable working hypothesis or something that might be predisposing to illness. So we used a facial emotion go no go task that had been used in people with established illness. This is a task that activates the inferior frontal gyrus and the anterior singlet cortex in some studies. The particular task where we found abnormalities was inhibition of response to fearful faces and a very striking result when Gloria first told me about this I said there must be an artefact or problem here. Michael's gone over it and convinced that really this is a very solid finding and that on the whole brain analysis there was a reduced activation with inhibition to fearful faces in the inferior frontal gyrus, an area which clearly is of interest in terms of mood disorders. This is a whole brain analysis and survived multiple correction. So a very strong finding. This is consistent. There was a recent meta-analysis in bipolar disorders and the summary statement of that was that there were two areas that came up in the functional imaging tasks in people with established bipolar in the main areas with inferior frontal gyrus and ventral lateral prefrontal. So it looks as though that we're picking up the same area that's been picked up in a number of the studies with people with established illness. The only, so ours is the only functional study that's been undertaken in a high risk population because it's so few of those and we're the only group actually doing that. There's a paper looking at diffuse intense imaging that was published just three weeks ago and it's in press in bipolar disorders by the Scottish group and then demonstrated abnormality in with diffuse intense imaging in white tracts in the brain of people with bipolar disorder at risk for bipolar disorder. Like our sample, none of these have established bipolar disorder at the moment. So both at risk samples. So both studies, ours functional which we're writing and preparing for publication at the moment submission for publication and the structural study of Andrew McIntosh suggests that you can actually demonstrate in an at risk sample imaging abnormalities. I think this is really a new way of looking at the illness and I was not sure whether we'd be able to demonstrate this. So whether you're looking at structural or functional, there appear to be demonstrable differences between an at risk group and controls. I think I probably made most of this points. We're looking at correlations with genetics to see if there are any obvious genetic determinants of these functional findings but it's suggestive that there is a predisposing or pre-existing difference in how people at risk to bipolar actually deal with emotional challenges. So where does this take us? I'll just finish off with acknowledgments to colleagues. I doubt that it's going to be one factor that is going to be clinically applicable. I suspect we're going to be looking at an algorithm of clinical imaging, perhaps genetics, maybe neuropsychs. I think this is a very interesting story and I think looking at our translational focus that these sort of studies really have the capacity to influence future service development. So thanks very much, Mr. Jay. Good.


finish points right here 49 38 39 40 41 42 43 44 no A chicken wing up to your armpit. Our purpose is training for Victor 1-2 as well as Alpha Company specifically as the IBEX company moving into our strip maps next week which is a squad infiltration testing this 20-30 infantry squads. We're doing a series of physical assessments. So through the week we've done a 500 meter swim where we've tested the Marines ability to move through the water as well as we did a 5 mile run yesterday and then into the double low course today. Each of these are an assessment where we can determine where we are as a unit as well as we can compare both legacy units, our Charlie Company, a two Alpha Company with our different experimental the maturity of our squad leaders utilizing staff and COs as squad leaders, sergeants as team leaders. The ability to compare both physically during the physical assessments as well as next week when we get into the tactical realm, compare across the two companies. So far I think it's going well. We're in the early stages of IBEX so we're still getting some of the equipment, we're still getting some of the people, but we're testing is what the Marine Corps wants us to do. So we're testing the idea of the new teams, we're testing the idea of having more mature unit leaders and how that's going to affect our ability to fight and win the future wars. I think as we look at force design 20-30 and the new infantry model, either way whether we're legacy or experimental, we still need to be getting out here and doing the obstacle course. I think it's no different from what we've done in days past. The obstacle course is nothing new to the Marine Corps and now we're just taking the new model and the new 20-30 infantry model coming out here and doing the training that Marines have always done. In terms of how this impacts the Marine Corps as a whole, Alpha Company 1-2 being the IBEX company, again getting out here doing the legacy obstacle course, some of the very natural physical events that Marine Corps has always done is going to make us more proficient. We're taking a unit that has a little bit different people, have a little bit different things still accomplishing some of the old tasks that we're assigned to all while also focusing on what the future of force design 20-30 looks like and the infantry model in the future.


Live from Cambridge, Massachusetts, extracting the signal from the noise, it's theCUBE, covering the MIT Chief Data Officer and Information Quality Symposium. Now your hosts, Dave Vellante and Paul Gillett. Hi everybody, welcome to day two of MIT IQ. We're here at MIT's Tang Center. This is the MIT Chief Data Officer Conference. It's the ninth year of this event and theCUBE is in its third year of coverage here. And this event has really evolved from one of a focus on information quality, which is kind of a very boring but important topic, but with the big data theme exploding, it's really evolved into a Chief Data Officer and more of a big data and even evolving into an analytics event. I'm here with Paul Gillett and Paul, I want to talk a little bit about the sort of evolution of not only this event, but the role of the Chief Data Officer. As I said, it's sort of the boring but important category and it's still got at least one foot stuck in that camp and there's seems to be a bubbling up of desire by the community to really focus on innovation. And so we heard yesterday, for example, that maybe the title should be analytics and data or data and analytics and many people are proposing putting analytics first. Analytics being the engine of innovation for a lot of companies, but still there's a lot of discussion here around governance, certainly security, where does that fit into the organization? You're in the keynotes this morning, what's your take on what you heard and what I just said? Well, I think the analytics angle is important, Dave, that's a great point. The problem with that being that the title then becomes, the acronym becomes CAD, C-A-D, so we're going to have to figure that problem out. But you and I have been covering this event for three years now and it's been very interesting to see how it's evolved. Two years ago when we were first here, the Chief Data Officer concept was really new and people were sort of talking about, well, what is it and how is it going to evolve and do we need it? And then last year there was a lot of excitement because we had people with CDO titles who were here and we had, and of course in the last year we've had the White House establishing a Chief Data Officer and just a lot of bubbling enthusiasm over the growth of this concept and how this was going to take over the world. This year, you're familiar of course with the Gartner hype cycle. I think we're a little bit in a trough of disillusionment right now. I'm hearing CDOs and these panels talk a lot about data quality problems, about data structure, about the need to get a handle on the data they have. It seems like a lot of the work that they're still doing is basic bricks and mortar, finding out where the data is, getting it in a form that's useful, figuring out what the governance principles were. Very interesting discussion this morning came up over what is the role of the Chief Data Officer? Is it to permit or to enable access data or to restrict access to data? And one of the panelists was Nick Marco who we had on theCUBE yesterday and works in the healthcare industry and he was saying, we've got HIPAA, we've got this 20 year old rule that basically said you can't do anything with data. And yet we have, and this new concept of big data comes on and suddenly we want to do things with data and you know what? Our patients want us to do things with data as well because it's going to improve the experience for them. But we've got government rules that say, no, thou shalt not touch. And so the CDO in healthcare is in sort of a sentry, a guardian role, which is really the antithesis of what we want to do with big data. So I think there's a bit of a crisis going on right now of trying to figure out how this role goes from being a caretaker and an architect to being a business enabler and an innovator. So I think there are a lot of similarities with what we were talking about yesterday with one of our guests about the whole notion of governance and compliance. And it really started in 2006 when the federal rules of civil procedure came out and essentially made electronic documents admissible. And what happened then is every company scrambled and there were a number of high profile cases like Morgan Stanley was one and there was hundreds of millions of dollars in lawsuits and were judges who just didn't understand well, why can't you produce an email? What do you mean you deleted it? So everybody scrambled to try to plug that hole and they were focusing on little pieces of that. And then what happened is it became very much a procedural thing because plaintiff's attorneys would attack the process. So if you could show that you had a process, then you could say, well, and it's technology and it's really complicated, but we have a process and here's our process. We delete everything after n number of days or we retain everything for this period of time and then we defensively delete it. I think as the industry has become more sophisticated and technology has become more sophisticated and the legal systems have adapted more, the processes and infrastructure and software has to evolve as well and it is. The problem is there's now so much more data. Now the other piece is that you've got this idea of information as a liability. This is why you need a guardian. And you've got information as an asset and with the big data meme hitting, information became more of perceived as value as opposed to this thing that we have to manage through a life cycle. You still have to manage it through a life cycle, but that was the sort of tail wagging the dog where the general counsel was sort of in charge and now the lines of business saying, screw that. We have an opportunity, I'm going to run with it and I'm going to initiate a project and Hadoop or whatever, analytics project, the CMO versus the CIO spend, i.e. the CMO spending more than the CIO and they don't care certainly as much, if at all, about governance compliance and maybe to a lesser extent security but they may not be in a position to affect security the way they should. As a result, those pieces, those corporate edicts get bolted on which we know is a recipe for disaster. So that's the interesting tension here is asset versus liability and I think that's a balance that the CDO is going to have to manage. At one point, we felt like it was the CIO's job to do that. It never became the CIO's job. So is it the CDO's job? Well, I think it's, your point is great. It's the, this is exactly the kind of issues that CDO's are dealing with and there is precedent in what CIO's went through for many, many years. The CIO's went through exactly this same problem. Your role on the one hand is to protect and secure. That's your primary role and your secondary role is to enable and to innovate. And what happened is I think CIO's got so focused on the protect and secure that they became the guys who said no. And that was negative for the CIO, the perception of the CIO role. I don't think CIO's have ever really recovered from the perception that they are the naysayers, the people who frustrate innovation. And I think you're right. CDO's are entering exactly this same kind of problem where they've been given responsibility for this hugely important asset. And on the one hand they have to protect it and certainly in regulated industries that's job one. But on the other hand, you've got to do something useful with it and the business people are pounding on the door saying we need access to that data and here's the CDO being the guy who says no. And we heard from Sandy Pentland yesterday about Enigma, basically inspired by the Bitcoin blockchain, potentially a new architecture for internet security, but also privacy and the notion being okay, encrypt everything, distribute it into a black box, never share the raw data, never expose the raw data to anybody and eliminate the need for a trusted third party, which increases your threat matrix. A whole new concept. The problem, of course, is how do we apply that to all the applications and data that we've created? It's getting people to use it. Right, I mean the government just suffered a theft of 21 and a half million records of federal employees. And it turns out that these records were stored in plain text. They weren't encrypted. This is the federal government. If the federal government can't set an example for industry, what's industry to follow? So this is basic blocking in tact. I think what Sandy was talking about, this idea of a trustless encryption scheme, is a fabulous concept, but getting people to use it. We can't even get them to patch SSL, right? Right, right, right. Huge expense in order to do that. So maybe this says the security business is going to be a good growth business for a lot of the companies that we follow in this space. But nonetheless, I think that it underscores that example you just gave and many, many others underscore the security with this cloud, mobile, big data, social world. It's kind of a do-over. You hear Intel talking about putting security at the chip level. We hear folks like MIT and others, IBM's been working on this and Samsung's been working on a similar type of distributed scheme. Again, inspired by the Bitcoin blockchain as a new sort of paradigm for security, but the implementation of that is going to take decades. Well, the encouraging thing about what Sandy said yesterday I thought was, we can solve the security problem. You know, there is no reason why we ever have to unencrypt data. And once data is permanently encrypted, then you don't have a security problem anymore. The problem, again, is the devil is in the details. And getting the blocking and tackling of these kinds of technologies to be broadly adopted, it just doesn't happen. So I think that one of the things that comes into focus at events like this is the organizational issues. You know, we heard, well, first of all, who has a CDO? Most companies still don't have a chief data officer. I think it's very clear that in finance, healthcare, government, it's happening and will continue to happen in this momentum there and it's seeping into mainstream. But mainstream has not adopted this approach nearly as much as those three industries. In fact, if you go to a lot of the conferences that we're at and you ask people who thinks there should be a CDO that's separate from the CIO and shouldn't report to the CIO, many in our industry feel as though that it's not necessary, that it's the CIO's job, which I think we agree it's not. But there's a chief security officer in most companies, most global 2000. Where does he or she report? Does that report now into the CDO? So there are organizational issues. Where does the CDO report? Well, do I have a CDO? Where does that CDO report? Where does the CIO report? We flipped a lot from COO to CFO, sometimes even in the Y2K days it was the CEO. So that's been sort of a musical chair. So there are significant organizational issues that have to be resolved. Have you heard much here about those? I think with the sub theme of almost everything, everybody's talking about is organizational because they're talking about, we're still talking about what is the CDO responsible for? And so that fundamentally comes down to whom does he or she report to and what are the metrics for success? So I absolutely. Yeah, so it's interesting. So we're going to be talking about this and other topics today. We've got a lot of practitioners on folks from MIT. We've got a lot of guys coming from the government. Government, yeah, our first guest from the Office of the Undersecretary of Defense. Right, so a lot of good thinking is going on within government organizations, building frameworks and processes and beginning to implement them. So we're going to unpack these issues today. This is day two, MIT IQ. We've got a crowd chat going at crowdchat.net slash MIT IQ. So weigh in there, ask us questions there. This is theCUBE. theCUBE is SiliconANGLE Wikibon's live production. We go out to the events. We extract the signal from the noise. Myself, Paul Gill and Sam Cahane will also be sitting in today. So keep it right there, everybody. We've got a day long at MIT and Cambridge Mass. We'll be right back.


In today's video we're opening 100 packs for the new year 2024. What's up guys, we're back with another 100 Yu-Gi-Oh! pack opening that includes new banger packs, old school banger packs, and some in between that I think you guys are going to enjoy. Before we actually hop into it, we have the first giveaway of 2024. And I thought this would be a perfect giveaway. The Dark Magician we just pulled recently in that insane video the other day. Go check that video out. It wasn't just the Dark Magician that we pulled, the pulls were just ridiculous. The chances of us getting all the cards we did in just 71 packs was absolutely ridiculous. So go watch it. It was amazing. But you guys can win the Dark Magician from that video. Just like the video, be subscribed, turn on notifications. Let me know down below. Will we pull something as good as that video? It's gonna be hard to match up to that, but we do have some amazing old school, new school, really good new school, and some middle stuff. So I'm excited. Let's get to it. After eight months of waiting, your favorite series has returned and it's better than ever before. This is a new season and things have changed. Your favorite creators, a massive grand prize of $1,000. Get ready for guess that price season two. First of all, I want to say happy New Year to everyone. And we're going to start it off with a rarity collection pack. What better way to start 2024 than a rarity collection pack? It was a great year in 2023 and I'm hoping 2024 will be even better for everybody. Hopefully you guys are excited for the new year. There's a platinum rare or whatever it's called right off the bat. We have savage, not savage strike, savage dragon. Very cool. So off to a decent start. I'm pretty excited, very, very excited for the new year. It's always fun getting into a new year today. A lot of you guys, you might be watching the College football playoffs, probably what I'm doing right now, you know, because it's not actually the new year when I'm recording this, but I will be doing that when this comes out on the new year. See what I'm saying? Pretty nice. Okay. I didn't do any Patrick here because of the dark magician. Okay. Dictator of D nothing too crazy there. But yeah, pretty excited to see what's going to happen there. I mean, if you thought Florida State got snubbed, let me know in the comments. If you didn't, if you think that they should always put Alabama in every year, let me know as well. So let's just keep going. Genesis impact first today. I have one pack of this. Not a great set, but collector rare potential. I just, I grabbed some stuff I had and I threw it in here. We have some really nice old school that I think will be really fun. We have some high potential there. We have nightmare Phoenix. I love that CR. That'd be really, really nice. We've got the majesty's drive away. Okay. If this is not again, because like some of these collector rare sets, they always have the hollow in the back. Some don't. If it's not like that, then we got something star drawing very cool. Okay. So they're always in the back because that's just a super. No big deal. No big deal. Let's open this age of overlord pack. I mean, we had such good luck with age of overlord about the chaos. And what was the other one you open up cybernetic cyber code acts cyberstorm accent. I can't get that right. I'm never going to get it right. We had such good luck.  Okay. So we're starting off very slow, but we do have a hundred packs here and a few of them include 25th anniversary metal raiders, which I'm very excited about MRD first edition is not here. This is a 25th anniversary. But first Ed would be pretty cool. I'm going to do reef in the back real quick. Okay. Yeah. So while it's not first ed larva, all the cousin moth very nice. We have a deep sea shark, blue and crown big guy and belay fly and mirror floors. All right. There we go. Our first big pull of the video. It's not going to be big in terms of value because you know, there's a lot of these prints out there, but mirror force MRD is mirror force MRD. We cannot complain that sweet. Too bad it wasn't a first edition pack like I accidentally almost said there. That'd be pretty nice. First edition mirror force. But alas, that is not the case rarity collection. Here we go. New year 2024. I have a good feeling we're going to pull something for the top 25 pulls of 2024 in the first day of 2024. Watch this. It's going to be crazy. No number 100. If we get the ash that might get there. We have Luna. Oh, oldie droplet. That's pretty nice. And then a fairy tale Luna again. So that is a nice oldie. So it looks like this box I'm opening is not a Jarvis Johnson box where you can't get alternate areas. I'm still mad at myself for accidentally giving away that box. So whoever got that and got all collectors. First of all, didn't mean to send you that box because now we can't make the video and sorry to get the oldies. Okay, on to the next pack. Battles of chaos. We do actually have a lot of legacy of darkness today. So I should probably start opening some of those as well. Mix those in. We have smorg and pretty. We do have some first at packs first at IOC in this video. If we pull a chaos emperor dragon that will be in the top polls for sure. Magikaribo. Okay. That's a hit. Banger. Magikaribo. Very nice. So speaking of legacy of darkness, let's go open one unlimited print, but still very, very cool. First edition would have been pretty awesome, but I will take an unlimited yata unlimited fairy lily, whatever you want to give me Tyra dragon. I wouldn't be mind convulsion of nature wouldn't be mind. I would mind is what I'm trying to say. Sprite gunfire. Dragon's gunfire. I should say a little bit different rebirth. We have a maharagi throwstone unit. We have super robo yaru and Sousa soldier. And no, he's not the Sousa no soldier. And that's a big difference. Okay. He's just the Sousa soldier. So he's not that cool age of overlord. I have high hopes for you. We did not put. We pulled a SP little night the other day. We did not pull a wanted though. A wanted would be pretty fire. I can say that I want to pull the wanted stars in the line. Okay. I got to stop starring. Speaking of stars, we have starring snake eye oak. That was a rucks and special who would have thought rucks and specials already spell ruler 100 pack opening is going to the epic 123. We are going to pull something big. We have a mirror force so far, which is not a bad start. We also have an ulti droplet. I bet that's not bad. Okto bursar. We have servant spark queen bird. We have shining angel and course of sanctuary. Let's try another battles of chaos first edition. Here we go. One, two, three, four. We have a dog mad at come a cabaret. We have Venus mad hacker. Give us that dark magician again. Why not head hunt? We have I would like a starlight as well brain and disciple. So a lot of great starlights in your illusion of chaos. Blue eyes jet dragon the what's the other one? So one other really nice one in here dark magicians speaking of blue eyes jet dragon while it is not a starlight. Now I should mention this. This has foil bleed. I get messages about foil bleed nonstop. People are saying I think I have a starlight. Is this a starlight? No, this is not a starlight. This is a secret rare where the secret rare foiling just kind of shows through the card. It happens a lot more often in European cars, especially battles of chaos. You can see it pretty well on here how the secret rare goes to the text box or the name all that different stuff. That's not supposed to happen, but happens quite a bit. It is an error, I guess, but not going to add value. Not like I am now rich kind of error. It's just like a kind of cool and looks pretty nice. So while that is not a starlight or an error or a big error, I will be very happy because blue eyes jet dragon is one of my favorite cards ever printed. So that's pretty sick. Battles of chaos was absolutely amazing to open. We have a starting startling stare rose papillon, shine oberanus, what kingdom? Watuna, Numeria. We have a master tile, the chanter, pit night Philly and a switch point. We are switching the train. We are not pulling anything crazy. Let's do a little 25th anniversary legend of blue eyes, white dragon 123.  Been a while since I pulled one even in 25th. Let's are dragging a blue flame wasteland. Probably since it came out monster egg, red medicine, silver thing. Oh, rocks and special right to the trihorn dragon. Okay. I can't be mad. It was a secret. So if we're going to rocks and special, it might as well be a great card. Trihorn. It might. I think trihorn might like me even more than Genzo because we pull it crimps. We pull it in the first pack and the whatnot stream.  I just pull trihorns immediately. All right, rarity collection. Give us a quarter century ash blossom, please. I would not mind pot of extravance. Cyberangel Benton called by the grave, the Cherubini. That is nothing that we are looking for. So cool cards, but not exactly what I'm trying to get. We have age of overlord. Here we go. One, two, three, four, alpha summon, origami goddess, Jen, the diamond tiger, red arrows, what asset? Repeter. We have full armor and exceeds and a king sarcophagus. When I saw the spells like wanted wanted. No, not wanted King sarcophagus. Another good ultra though, we will not be mad about that one. All right. Next pack. We have a first edition eternity code right here. If I can get it out, there we go. Can we get that access code talker secret? Can we get that effect failure? Secret can we get that area of a water charmer? I believe starlight. I'm trying to say starlight for the effect failure. Thunder dragon lord. We have pride of the plunder patrol torpedo takedown. I see survived splash, princess, deep sea, super every samurai, wagon proxy of magician and red rain, the rain of the red. And speaking of red, we are in the red right now, but that's okay because we have metal raiders, which will bring us back. It will bring us back for sure. Metal raiders is the goat. One, two, three, four. We have a bickery, a bickery box, guarding the lab, seven colored fish, Gazelle, yada car, deep sea shark, Kojikazi, lava battle guard, magician Defe and I do the wrong Patrick. I must have done the wrong Patrick. So vision of faith that was anticlimactic, but hey, that's a good rare. And you know it wasn't going to be a 100 pack opening without a few of these goes from the past. If this is the moment where we finally pull it, that'd be pretty wild. We have resonator. It's going to be wild no matter when it is because it's been so long. Hieratic. We have an adult shake. It's it's made itself infamous in that regard. We have hell should all hollow. Wow. Hell should all hollow. Never seen that card before. Let's try a little legacy of darkness unlimited. Not first edition, but yada injection fairly. I don't know which which one it is. I'm going to look either one. I'm going to be happy. One, two, three, four right here. Let's get a secret gray wing ready for intercepting. You're trying Z plan Z can possibly fail. Plans he's to pull a secret rare. Here we go. Does that start soul? Not a secret, but an ultra he know Kago Suchi. I always pull this guy, you know Kago Suchi. He's very cool though. Check him out. He's like, yeah. All right. Rarity collection back at it. We're doing our best to pull something crazy. Here we go. Nightmare Unicorn. Visionary Affairs secret. Okay. We have a ulti galaxy has full armor photon dragon. Not a great card to be honest. Pretty low in terms of the old sweet. It is an ulti right? Yeah. Mission salvation and iris sorts also is high rarity, but it is not exactly what we're looking for there. Speaking of what we're looking for starlight rares battles of chaos. First eddition. Here we go. Dynamorphia Diplos. Mad Hacker. Dollmonster. Great double cast and caster. Conjurer. Rock Scales. Noru. Kaiser. And for wonder reason, the advent adventure ultra. That's a good one has had a reprint. I think but it used to be like a really big card in terms of ultra rare. It's like $15 was that Kim can't compare to the cyber storm access. What was the card called? Dispater $38. It's absolutely ridiculously high. One, two, three, four. Come on age. Give us something big. We have show devil. We have to Stina exceeds lightworm evolution wrap and divine temple of the snake eye. Snake eyes. Never want to roll those snake eyes. Okay. Let's try a little King's court. We have not had King's court open in this video or not very much in general in a long time because it's pretty old set at this point. Golden eyes. I don't we got the ultimate shield or rescue rabbit. We can Dreadroot. Stellar. Whoa, back to back. Same card. That's weird and the hyper galaxy. Very nice, but not nice enough. Metal Raiders speaking of nice. This will bring us back because we are we're doing okay so far. Like we're not doing bad. We're also not doing awesome and I would love to be doing awesome. We have Lady Defei. That will help seven goldfish paralyzing potion grotto common area attack launcher spider labyrinth tank the combination of gigatech wolf cannon soldier. We have a sanguine and we have. Suijin very nice. The beasts of water. Wait, does they say beasts? Do they say beasts? Water, wind and earth combined together and make guardians of rebirth. I don't know what they say. The only thing I know for sure that they say is what is this? All right. I got you guys. It's been a while since I've said what is this, but once Jarvis put it in his video, they reminded me that I needed to. I was like, look, if he's going to say what is this I got to bring it back. All right. We have a labyrinth scapegoat. It was a it was a staple back in like 2020, 2021 and labyrinth setup. So nothing crazy there. That's okay. That's okay. We got a lot of packs left. We're not we're not freaking out yet. Speaking of freaking out, I would love to be freaking out after ghosts in the past is open. There's only one reason I would be doing that. One ghostly reason. No J. Putting says Winder drew any fainlinks. That's to lose the Mega Monarch. All right. No luck so far. You know, let's do a Labyrinth of Nightmare. I think I have like five of these packs. There's a lot of potential here. Let's see if Labyrinth of Nightmare can pull us something amazing. Here we go. L-O-N unlimited. Gemini elf would be really cool. I like magic cylinder just as much. So I would not be mad to pull that blind destruction. We got the stroll of bewitchment. Rock spirit, flame dancer. This monster moves while swinging. It's burning rope. Watch out for the burning rope. Boneheimer unfurling Amazon. Swordsman of land stat. Joey Wheeler. We have Baital. Ann. Oh, the last warrior from another planet. One of my favorite cards. Not, not just in L-O-N, but in general, I love this card. That is so awesome. Oh my goodness. That thing looks like it's in great condition. I might grade that even though it's unlimited. So not like crazy value, but this is such a cool card. This is such a cool. That's one of my favorite pulls so far. Probably my favorite pull. Just in terms of maybe it's a little off center. So maybe I'll just keep it. That's such a sweet card. Okay. That is a good old school pull. So we are having some luck here today. It's not been too bad for, you know, it's going to be tough. Sometimes with old school packs. Okay. There's another platinum rare. We got two of those dark laws. Pretty good and Celine and pre-preparation of rights. All right. Rarity collection just doing its thing. You know, we've got a battles of chaos pack. Here we go. One, two, three, four. We have Dynamorphia Brute. So it's all strife. Ghost trick or treat. Tribe drive. We have a ghost trick shot. Kaiser. Ice Jade. Diddy headhunt and vampire ghost. This is not a great one. This is an ultra rare. So not guaranteed. So anything not guaranteed. I'm not going to be mad at. Oh, I've got, we've got something good coming up here. Of course. I got to put this to the front because it's so good. Legendary duelist soul burning volcano. So you might be like, why is this the 100 pack opening? It was the stinkiest set of the year. It got the award in the top 10 sets of the year. Go check out that video if you missed it. But yeah, this is, uh, here's why we're opening this. Cause as a ghost, it's worth 88 bucks at the moment. It also has a $25 ultra. So there's a couple of cards I would like to pull. We have all Mirage, Joel counter and battle unboxer. So we did not get it there. Probably not going to get it, but there is a couple cards that I would like to pull. Now let's try a little duelist pack crow first edition. So this is one you don't see every day. Not a lot of probably high end cards in here, but it's pretty cool to see these old duelist packs.  That's a hollow. So we got something. Should I say a foil? I don't even know what you guys want me to call it. Some people complain about that for the spear. We have Blizzard, the far North and against the wind. Very cool. A little set list going on there. That's pretty cool. We have some of the rarities on there. Yeah.  So those are the supers. The ultra looks like Zephyrus, the elite and jet stream, the blue sky. So those are probably not going to be crazy valuable, but that's still pretty cool to have that little checklist. And we actually got something. That's pretty sweet. First edition super pretty cool artwork on that too. All right. When the soul burning volcano, you're going to have to wait. Let's go back to rarity collection. See what we can get. We have a ash blossom. That's something we have danger jackalope, fairy tail Luna, ice dragons prison and nightmare unicorns. Still no QCRs yet. Wait on those QCRs. Let's see if angel of overlord can help us out a little bit here. SP wanted Horace. Any of that stuff would be great. We have IAS invasion, alien species, startling stair, rose papillon, shot of Baron, repetitive. We have bride doll, we have light warm and burning. The dragon, the dragon is burning. That is a chaos.  We don't want none of that. One, two, three, four. You don't burn us. You bless us. Top share. We have tour ride, doll happiness, smile potion, clear. Epsilon, Dino Morpheus, Dino Morpheus shell, white relic of dog medica. It's time to open a Labyrinth nightmare $4 and 49 cents for this one. Will this be the pack that gives us something crazy? We already got pretty good LO in pack. So I'm hoping LOD can kind of match that. One, two, three, four. We have Convulsion of Nature, Woodland Sprite, Dragon's Gunfire, Wingbeat of Giant Dragon, Serpentine Princess, Spear Ryu, Spiritual Energy, Settle Machine, Super Robot Lady, and Lesser Fiend, Machamp, Yu-Gi-Oh version. Okay, not bad. Not bad at all. Let's go back to rarity. That's Soul Burning Volcano. It's calling my name and saying this has a ghost rare inside. Give us a QCR. We have called by Time Thief Redoer. That's an ultimate. So we're getting all ultimates right now. Ash Blossom, Collector Rare. So it's not the QCR. That is a pretty good one. CR Ash Blossom is not bad at all. That's a banger. Time Thief Redoer might be okay in terms of ultis as well. All right, Soul Burning Volcano time. Here we go. Let's see what we can do. We have Battle and Box of Glassjaw, Sanctuary, Volcanic Rocket, Volcanic Queen, and Headgear. Okay. Good stuff. I'm getting invited to a Pokemon Go raid right now. So we will not be able to accept that one, but Pokemon Go, if you guys want to add me, go check out the Discord down below. I have my Pokemon Go code in the Pokemon Go chat. You can add me. I will add you back. You can send me gifts. You can invite me to raids. I may or may not accept them. There's another secret rare. You know, I might be recording like right now, so I can't accept it, but I would like to do some legendary raids like Regigigas right now. So that could be pretty fun. Also, if you have not already, go check out my Pokemon channel. You're working on a new video at the moment. It's been a couple months because, you know, Yu-Gi-Oh comes first. So I have to put that on the back burner sometimes and it takes a while to make those Pokemon videos. But if you're over 5,000 subscribers now, we've had a couple of big videos. It's just been really exciting. And that's going to be, I'm going to try to not necessarily focus on that because, you know, I just want to try to get out more videos from that channel in 2024. I'm going to have another update video probably on some of my goals for this year and stuff like that coming soon, kind of like we did last year. And it actually worked out pretty well. It gave me some goals to work out for the year and I liked it.  We have Joker straight. That's an ultra. Okay. Kind of hidden some good stuff. A geek boy, not a great secret, but not too bad. We also had some boil bleed on that. Let's try a or and I should say with this one Invasion of Chaos unlimited, but this is original. So let's see if we can get CD, DMock, you know, Blackhorses or Soldier, all that cool stuff. We have a Hero Merges, Death's Kangaroo, Perkle Fairy, Coach Goblin, Grippin's Feather Duster, Inferno, DNA Transplant, C-Zurban Warrior of Darkness, and an Ultra Evolution Pill. So that's cool, but it's not exactly what we're looking for. Let's scoot these over a little bit. So we still got a lot of packs left. I don't even know if we're halfway through this. Might be a long, not might be. This will be a longer video.  Let's grab a QCR in the next slot. I messed it up. Okay. No, it has to be in the second slot. Doesn't it? Nothing in that one. Brady is not giving us those QCRs. Let's see if we can change that soon. But we don't need a QCR. We've got a Ghost Share, Dark Magician. Let's go. Alrighty, Dragon King of Atom. Time Thief Redoer. Danger Thunderbird. Metapholes Counter. Sunvine Thrasher. Cards are cards, but they are not the cards I'm looking for. Let's try Age of Overlord. The Age of Overlord has come. One, two, three, four. Gaia Prominence. Loka. Sweet Roomade. Conquers. Soul of the Supreme Celestial Being. Escape Goat. Watuna. Bridal. And what is this? Burfumet, the Mythical King of Phantom Beasts. That's the Burfumet Retrain. A lot of words in his name, though. Alright, time has come. Let's open our third soul-burning volcano. They got to be first half Tiger Packs. They can't be finishing with soul-burning volcano, even though it does have a Ghost Share we want. Wall of the Selmangreat. Will of the Selmangreat, not Wall. That's a Ruxus Special. Right to Volcanic Trooper. That's a good way to end that. Ultra Rare. I don't think Volcanic Trooper is a crazy one, but it might be a couple bucks, which is nice. Now let's do a Battles of Chaos. How about that first edition? Battles of Chaos. Longer video to start the year. Hopefully you guys are having a good...  Which is great. So hopefully you're enjoying it. If you don't have the day off, I'm sorry. Hopefully you're enjoying it anyway. Monster Rebirth, Maple Maiden. Doll Monster. Nordic Relic. Super Rare. What do we want to do now? Ghosts from the past one. We have two more packs of this. This is the second to last chance for this video. Time to fly back. We have the... Lavalval volcano. Fairy Tail Tails. Starry Night. Time Thief Adjuster. Not a bad card. Not a bad card. We have definitely pulled worse in this video, but also not that crazy. Let's do another lot. Legacy. Not a lot of them. Legacy of Darkness. Nothing pulled out of Legacy yet. Well, we got Hino Kagesushi. That's not... Yeah, not true. Got one Ultra so far. Just pretty good to be honest. Ultras are pretty few and far between in the old school sets. We have Gradius Option. The Puppet Magic of Dark Ruler. Gray Wing. Ready for Intercepting. Fushi Notori. Serpentine Princess. And... The Shadow... Gamer. Taming those shadows. Do not tame the QCR. Please give us one. We've not gotten a single QCR yet. Imperm. Here we go. Yes! Oh, okay. Ghost Bell. That's not a bad one either. Ghost Bell and Haunted Mansion from Endroplet. Wait, okay. I don't sleep. Pretty good pack right there. Haunted Mansion QCR. I'm gonna be like huge money. Not... It's on Ash Blossom level, but still not a bad... What's happening here? Okay, it was sticking. Okay. Ghost Bell and Haunted Mansion. That's a pretty good QCR to get. I will take that. I'm not mad at all. Now we are grabbing that Battles of Chaos. Had great luck before. We did pull a Dark Magician recently, but I'm really hoping for that Starlight now. We have Sonic... And Sonic and then a bird. Interesting. A Sonic bird is created there. We have Darten and... S-Force Retro Active. Spell Ruler time. 25th Anniversary. Probably have about half the packs are a little less left. Probably about half. We have Malevolent Nuzzer, Gaia Power. Tyho, number two. Ryu Ran, Umiruka, Hamburger Recipe, Stone Ogre Grotto, Mystic Tomato, and Wall Shadow. The wall list of shadows. Let's go back to... Speaking of shadows, Labyrinth of Nightmare. Wall Shadow. Not in Labyrinth of Nightmare actually. Interesting how Wall Shadow and like... The Labyrinth Wall, weren't they both in Magic Ruler? It's kind of weird that they weren't Labyrinth of Nightmare. Lighting Konger. Okay, we have Dancing Fairy. Worm Dracke. Amazonus Archer. Fairy Guardian. Won't That Seek a Rare? Magic Cylinder. Offering to the Doom. We have Milk at the Foreface Beast. Summoner of Illusions. And Jaugen. The very exciting Spiritualist. Back to Rarity Collection. We're getting low on these. Only two more. Maybe we'll get another QCR because we only got one there. Code Tarker. Not that time. We have a Tour Guide. We've got a Plant Dragster Pelion and Fairy Tail Luna. So it's all going to come down to that last pack. We're going to get another QCR. Battles of Chaos. Down to two packs as well. Can you pull us something crazy? We have S'more. Groza. Doll Happiness. Ghostric Festival. Ghostric Shot. Ghostric Siren. Skilled Brown Magician. We have Dynamorfield Alert. And the Ultimate Fusion. Not bad. Age of Overlord First Edition. Can you give us something that's not only not bad, but also not good? It's great. How about that? We have Gaia. We have Invasion Alien Species. Wat Kayuki. We have Spirit. We have Asset. We have Fighting. And Wings of Light. Metal Raiders. Here we go. First Edition. What are we going to do? What are we going to do? We have Lady of Faith. We need some Locke. Skull Knight. Ancient Elf. More Infant. Tremendous Fire. Come on. We've already got a Mirror Force out of here. Harvey Leia. That's pretty good. Little Kymer. I did the Pack Truck wrong again somehow. I keep doing four. I guess I'm used to four. I'm going to Ultra Ruxus Special eventually. There's going to be an Ultra Rare or a Spit, like a Secret Rare right at the front. All right. This is a Wild Survivors. I think you've got to do two on Wild Survivors. We want to get that Hungry Burglar. Let's go. We have Frostosaurus. We have Preparation. We have... Okay. No Hungry Burger there, unfortunately. So we've got a Super. We've got a big old Dino. But it's not the one we want. How about we open this Yu-Gi-Oh! The Movie Pack 2004. Can we get the Blue Eyes Shining Dragon? I don't know where it's going to... I don't know where. I'm going to try to... Okay. It's that way. It's backwards. Perfect. Okay. Let's do it like this. Kind of have to do anything. Yeah. There we go. It's a good opening. That's very good. Okay. The card is here. We have Shonen Jump. There's only one card. There's only four cards in the set. One Super Rare, Blue Eyes Shining. I think there's like a... No, they all... The rest of them are all just... Commons, I think. Here we go. Another Blue Eyes Shining. I've tried to grade these a couple of times and I keep getting nines, unfortunately. But that's actually pretty clean. That one's probably going to get sent in to be graded. And I do want to get a PSA 10 at this at some point. Retro Pack 2 version would be nice as well, but it's going to be a lot harder. Starting off the year with a little Shining Ray of Blue Eyes. I love it. We have Ancient Age of Overlord. Not Ancient. Ancient Overlord. Why does that sound like a set? I don't know. We have TG Close. Intrust. We have Snoo, Snoo Devil. Little Wrap. Fila. Or Philly. Oh! And the Blessing of Horus. That's the wrong Horus. But hey, Secret Rare. That's the wrong secret. If it was the... Imniti or whatever his name is, that's the big one. This one's probably not terrible though. Okay, Rarity Collection. Here we go. Let's see if we can pull something else epic. Come on, Quarter Century. No, no Quarter Century. All right, decode one more chance. Okay, all right. A little bit of a dud to end it on a Rarity Collection. That's okay. We got a QCR Ghost Belt. Battles of Chaos. We've gotten through the ones where we have a bunch of them. Besides Legacy of Darkness, actually. One, two, three, four. We have Ogdotic. Last Chance of Battles of Chaos. Today, Ghost Trick or Treat. Darten. Silver Vine. Neroi. Noru. Ice Jade Creation Kingfisher. Sure. Age of Overlord. Last Chance. Can you give us another secret? You gave us one. Not necessarily the one we're looking for, but I take a QCR as well. We have Tostino. We have, I mean, QCR SP would be absolutely massive. Peacock. We have Ken. Transcitosaurus. We have Discordance. Earthbound. Sinful Spoils. So, no QCR SP a little night this time. Let's go to the Dragons of Legend 2 pack that I have. Dragons of Legend 2. Tune Kingdom. I don't know where it will be at the front. It might be at the front. There is a spell card at the front, so I hope it's at the front. I'm going to do this just to be safe. Tune Ancient Gear Golem. Pretty, pretty funny card. I like Ancient Gear Golem. The artwork on this is just really good. Black Catastrophe. Prediction Princess. Here's where we find out. Oh, Tune Mask. Oh, we got fooled by the aquarium stage. Tune Mask isn't a bad one though, so that's a nice secret. Okay, let's grab a Legacy of Darkness because we do have a few of these. Overall, the pulls have been decent. They've been decent. We haven't had a massive pull yet. The best or my favorite one is the Last Warrior, but that's not going to be a big money pull because it's unlimited. Let's see if we can get a nice, not necessarily any big money pulls in here that Yatta or Injection Fairy Lillu would probably be like 30, 40 bucks. Mirror. Maybe if you could get a 10 on them, they'd be worth a decent amount. We have a faint plan and... Bottomless Trapple. That's a pretty good one. Very off-centered as you can tell. Push it that way. Let's try a little Magic. Well, let's just spell... I have a couple of spell rulers. Let's do those first. These are 2003 spell ruler, but let's save the 2002s for after that. Here we go. Spell ruler. I take a Spell Ruler, Blue-Eyes Tune. Very, very happily. Dark Witch, Curse of Fiend, Crab Turtle, Snake Fangs, Rai-Ran, Reliable Guardian, Spear Cretan, Weather Report. Let's go Blue-Eyes Tune. UFO Turtle. That is... That's not even close to a Blue-Eyes Tune. All right, Dark Illusion Time. I have one pack of this first edition. There are some cool cards like Pot of Desires, which does have a lot of prints now, but pulling the original Pot of Desires would be pretty nice. I don't know the pack tricks. I'm going to do three. Pendulum Hole. Pendula, Performable Pal. I'm not Pendula. We have Scape Ghost. Scape Ghost. That must be the original print of that. That's cool. I've been opened a lot of this set like ever because I wasn't really around back then. And, you know, there's no Ghost or anything in it 2016 era, so I haven't really been excited to open it. But there are some really cool cards I've never pulled. We have Thomas. Let's say Thomas. I just ruined the review. Okay, that got confused. All right, Ultra Rare. Subterra Behemoth. Stalgmo.  I've a couple of times it's happened. I do not like them. All right, LLN. You've been good to us with a pretty big pull. But can you be extra good with a secret rare? I believe you can do it. I believe you can do it. One, two, three, four. We have the Earl of Demise. This gentlemanly creature will be pulled in this pack. De La Fanta. Flying Fish. Make a wish. We have Landstar. We have Maiden. We have St. Joe. Sphere Messaging. At least it wasn't an L. At least it wasn't an L. That would have hurt a lot more. I'm going to do this King's Core pack and hope for the best. King's Core. We're getting down to the nitty gritty of the opening. It's been a pretty...  It hasn't been crazy. We pulled a lot of stuff. Baxia. Jack's Night. White Rose. Cloy Stare. Let's try another Spell Ruler because we do have, I think, three of these total. We've already opened one. And then two more magical ones. So five total. Blue Eyes Tune right here. Unlimited. One, two, three, four. Relinquish should be cool as well. We have Peacock. Who's going to be watching football and Peacock? Not me. They wanted me to... They're trying to get us to do that the other day for NFL. I was like, no, thank you. Metal Fish. Turtle Rest. Darth Maul. Port of Light and... Amoeba. Amoeba. That is not going to do it. Amoeba is not exactly what we're searching for. Metal Raiders. No Pekingyo Moth is opening. We did get its Cousin Moth, so that's something. Oh, I did four again. If I do that, I need to pull this one back. Okay. We have Baby Dragon. I caught it. We get again. Very nice. We have Hunter Spider. Oh, Ruxen Special. Right pass. Saga, the Dark Clown to the Pekingyo Moth. That's very nice. Hiya, Subey. Ruxen Mini Special for the Thousand Dragon Secret Rare. All right. So I actually would not have Ultra Specialed it because they pushed this one up in the pack. So a fourth in the back would have worked there. But Secret Rare, last pack of Metal Raiders and a Pekingyo Moth. What more can you ask for? All right. Tactical Masters. Let's go. Runic Slumber, Bear Blocker, Vader of Darkness, Reckless Greed. Give us a Collector Rare right here in Pure Lion Wall. Labyrinth Set Up. That is not a Collector Rare. Not at all. But you know what might have not a Collector Rare? A Secret Rare. Legacy of Darkness. Here we go. Let's do this Legacy of Darkness. One, two, three, four. For the New Year. We have Greywing, Ready for Intercepting, Neutrion Z, Warrior Digreffer, Smoke Grenade of the Thief. Crazy for a while. Skull Knight number two. I think it's still banned. Dragons Rage, Reakish and Clown, and Thundern Eye End. It's Thunderen, but it is not really getting us what we want. Here we go. Curse of Fiend. Oh, I didn't do the Patrick 3 from the back. We have Guardian of the Throne Room, Chain Energy, Eat Caboon, Turtle Loath, Reliable Guardian, Whiptail Crow, Ruxen Special. Whoa. Okay, there's nothing there. Just Ruxen Special. For some reason, I thought there was something else there. Tactical Masters. Your last chance at this Collector Rare set. Pull something crazy. I'm not doing anything there. Dual Soliance. That is a name of a set. Cosmic Cyclone, Scapegoat, Quick Booster. We have Erunic Allure, Invalence, World. Shinra Bansho. The Shinra Bansho. That'll really get you. Legacy. We still have several, like five Legacy Packs left. I'm going to keep opening these. We have Twin-Headed Wolf, Bubble Crash. There we are. Robotic Knight. Double Snare, Devil Snare, Mirror. We have Darkness, Darkness, Darkness. Can't pull it. We have Fame Plan. Skull Knight number two. And Magic Reflector. All right. Wild Survivors, First Edition. Give us that burglar right here. The Hungry Burglar. We have Noebellus. There can be only one. Now at one, you know? There can be only one. Literally, there can be only one. We have Erotic Area Epidemic Virus, Imkantation, and... Oh! Collector Rare! Fire Formation! Jinky on the last pack! That is nice. Wild Survivors coming in clutch with a Collector Rare. Man, you don't pull random Collector Rares very often. I will take that. That is a nice pull. All right. Very happy with that one. Let's open this Maximum Gold Pack real quick. Eldorado, I should say. There is a set just called Maximum Gold. Not that one. Sideframe. Let's see if we can get a big one. Gold Sark. This one could have access code. Urgent Schedule. Number nine. And the Weather Painter Snow. All right. So nothing too wild in there. A couple of gold cards. Let's try this L.O.B. Pack. 25th Anniversary. Can you give us the Blue Eyes White Dragon? One, two, three. Beva Warrior. Armored Starfish. Basic Insect. Two-Mathark Ruler. Dissolve Rock. Root Water. Vile Germs. Aquamador. And the Lesser Dragon. A Minor Dragon. It's a Minor Dragon. Stay away from him. Stay away. All right. So that's some L.O.D. right here. So let's try L.O.D. We do have another ghost from the past pack. I think that one has potential. It has potential for being epic. One, two, three, four. Convulsion of Nature. We got Woodland Sprite. Dragon's Gunfire. Winged Beedah Giant Dragon. Almond's Fortune Telling. Mysterious Gar. Stamming Destruction. Spring of Rebirth. And we have Machamp of Yu-Gi-Oh. Let's try this Duelist Pack Crow. Last one we have here. Can we get one of the Ultras? We got a Super last time, which is pretty amazing because he's not guaranteed. Let's see. They're pretty early in the pack. So let's just go right into it. Raptor Wing Strike. Lever Returner. That's the second. That's a pretty good card. And then the Kochi, the Daybreak. So I think that's it. Fake Feather. So yeah, no foil in that one. We got pretty lucky last time getting a foil. Ghost from the past one time. Our last chance here. Come on. Dark Magician. I summon thee. Royal Prison. Backup Secretary. Metapoles. Dragonity. We're going to get one one day, guys. We're going to get one. Got a couple packs of L.O.N. Let's see if this can be the one. Labyrinth of Nightmare. Please do not be a Nightmare for us. Rock Spirit. Flame Dancer with the burning rope. Sorcerer. Masked Beast. Spherus Lady. I don't really see how this is Spherus at all. It's very interesting. It's tornado wall. Shining Beast. That's Spherus. Now that thing is very interesting. Mario Kutai and the spirit message I. Two spirit messages. Thankfully no L. Okay. Legacy of Darkness. Let's try you again. We're on a basically all old school here. So it's coming down to old school polls. Ready for intercepting. Nutrient Z. Radiographer. Dragon Dulling in the cave. Super Riju. Oda Hime. Bad reaction to Sumoshi. Robo Lady. An array of revealing light. More old school cards. But no irony. All right. Let's do this 25th anniversary and it will be straight up all old packs. This one's a reprint of an old pack, but not quite an old pack. Blue Eyes by Dragon. We have Sandstone. Yorabi. One Eye Shield Dragon. Skull Servant. Radiant Patula. Machine Conversion Factory. Immortal Number One. Cherubin the Fire Knight. And Dark Energy. The darkest of energies. Okay. Labyrinth of Nightmare. Let's try you once again. Will you be another epic poll or will you just have the one? Or can you double up in one video? I would love Dark Necrofair. I love Magic Cylinder. I love Gemini Elf. Headless Knight. We have Lady Panther. Grand Tiki Elder. Cure Mermaid. Gadget Soldier. Fairy Guardian. Offerings to the doomed. Milk of the Four Faced Beast. And a Mask of Dispel. So we did get another Hallow. Super Rare Mask of Dispel. That is very nice. That'll go well with our last worry from another planet. Okay. Invasion of Chaos Time. Original Unlimited Edition. We can do this. We can pull one of the big three. Let's do it right now. That'd be amazing. We have Amphibious Bug Routh. MK3. Raiyukoki. Pretty good common. Gale Lazar. Shellfish. Blasting the Runes. Neobug. Salvage. Dimension Distortion. And a DD Designator. We got a Hallow. It's not a big one. But it is a super. I will take that DD Designator. Very cool.  That's what I want to know. It feels like it's just a giant blade. That's what it looks like. All right. Back to Legacy. Because we do have four of the five of these left. There's three separate groups for Legacy of Darkness. It's everywhere. Let's see what this one will have. We have Devil Snare and Devil Snare. Soul Demolition. Convulsion of Nature. Woodland Sprite.  We have Barkadark Ruler Wing Minion. Burst Breath. And a Magic Reflector to protect your Toon Kingdom from being destroyed. Pharaonic Guardian. Haven't opened you yet, Pharaonic Guardian. You have a lot of nice comments. You've got some cool rares. You've got some nice high end cards as well. I like Don Zalug. I like Ring of Destruction. It would be awesome. Never pulled it. We have Vassal. We have Two Ton Mask. Time Eater. Needle Wall. Disturbing Strategy. Grave Keeper's Guard. Hylor of Glyph. Lithograph. Crywell. And I thought it was Ring. I thought it was Ring. Travel Border Racer. I mean, I can't complain. We're getting supers out of these old packs, which just doesn't happen a lot of times. They're loose packs as well. So you never know. Okay. I'll take that. Ring would have been so awesome. I would have lost it on Ring. Okay. Back to Legacy. The Legacy of Dogmas to destroy that pack. One, two, three, four. Double Snare and Devil Snare. We have Soul Demolition. Convulsion of Nature. Wild and Sprite. Burst Breath. Frontier Wise, man. We have Possessed Dark Soul. Super Rejuven. And Second Coin Doss. That's not a foil. Okay. I think it's time to go back to Spell Ruler. Last Spell Ruler pack. Then we have two more Magic Ruler packs as well that we could get something pretty epic out of. Let's try to get that Blue Eyes tune. One, two, three, four. Boar Soldier. Hamburger recipe. Psyche Kappa. Griggle. Roxton Special. Ceremonial Bell. Koto Dama. Octo Bursar. Hungry Burger. Good to see you. Didn't get the Collector Rare of you, unfortunately, but send you. Okay. So Magic Ruler. Pretty cool stuff or Spell Ruler that time. Let's do our Ancient Sanctuary pack. It is first edition though. So, Econ First Ed. That's what we want. Enemy Controller. Let's go. Kaiba. Enemy Controller. One, two, three, four. Sand Gamble. Let's go. Roxton Special. Wall of Revealing Light. Rocket Jumper. Monster Gate. Sword of the Soul Leader. We have Guard. Backfire. Three Oplacuda. And we have... Soul Absorbing Bone Tower. I've said it many times. That used to be a big rare, but unfortunately not anymore. Let's do this Legacy of Darkness pack. We are down to the final three, six, nine, ten packs. Last 10% of the opening. It's been a very long one. Hope you guys have enjoyed the New Year's Opening. If you have, make sure to subscribe to the channel if you aren't already. If you are, let me know in the comments what you're excited about for this year, what you want to see on the channel. Fate Plan and I will take it into consideration. Anything that we don't normally do would be a great suggestion as well just to see what you guys would also be interested in. Dragon's Rage. Let's go and look at that. That is absolutely Legacy of Darkness centering right there. Look at it. Oh my goodness. Yada has been pulled and it is barely on the card. That is amazing. I was just rambling about, you know, tell me what you want to see on the channel this year. I guess that'll be in a short as well because this is definitely got to be there. Yada Garasu. That is a beautiful bird card. That's the first time we pulled that. I've had a lot of Legacy of Darkness loose packs. We finally got a Yada. That is pretty amazing. Yada, I pull a lot more injection very little than Yada. So this is exciting. Very amazing. That's a really good pack and a really good card to pull in this opening. All right, guys. That is a really fun pull. A Yada Garasu. That's super awesome. Let's see if we can follow it up with another secret. Blue Eyes Tune Dragon. Yada is one of the coolest old school cards. That's pretty amazing. Is it still at one or have they put it at three yet? One, two, three. I feel like they could. Horn of Light. We have Sonic Bird. Tio number two. Psyche Kappa. Umi Ruku. We have Griggle. Final Destiny. Oh, oh, right. I hit three from the back. I guess I was thinking of the 25th anniversary packs. That's all right. Legacy, you got two more packs. These are actually separate Legacy of Darkness packs that are over here. They're like different from the ones I already had that I got the Yada out of. So this could have another Yada. In theory, it could. I mean, it probably won't, but it could or it could have injection fairly for all I know. We have Fiend Comedian. Wolf Axe wielder. Secret of the Bandit. We have a hundred of seven weapons with Maharagi. Throwstone unit, Super Robo Yaru. Bargadar Ruler. Oh, I thought we pulled another one. Not Yada, but Yamada Dragon. Oh my goodness. Legacy of Darkness with two Ultras and a secret and then an LO in over there with another Ultra. Old school pulls are going crazy right now. Just check that card out. Wow. That's a sweet card. All right. I think we do this with a weird LO impact. This is the one you get with the tactical evolution card. So it'll have, you know, railroad tracks on the card. You guys, I've referred to it as, you know, the back is slimy. It looks super weird upside down card. Okay. That could be a good sign knowing this product. We have Bio Mage. Hopefully it is August here or spirits. We have humanoid slime cure mermaid rucksons special. Oh, Anakin, you were the chosen one. Shining abyss. Mario Kuta. We got the portrait secret destiny board. Oh my goodness. A nasty slimy destiny board. Ultra rare. The amazing cards are showing up fast. That is very nice and ultra rare. That thing looks awful too. Just I want to compare it to another old school card. Look how heartlight. It's like hard to see almost. Let me get it out of the sleep just so you can see it. Look at that. And then I want you to look at this. Look how clear this is versus this. Like, wow, that one looks terrible. Okay. Six packs left. I'm going to do a dark crisis pack. Here we go. You're almost done with this video, guys. It has been a very long one. Hopefully you guys will enjoy it and are enjoying it at the moment because it's the new year 2024. So hopefully it's a good video. O'jham agree we have token Thanksgiving morale boost. Battles card. We have despair from the dark. Acrobat monkey. Sasuke samurai number two. And we can break and flamboyant bow. So far we've hit so many good cards like it's okay to hit a rare there. Five packs of 100 left. Let's do pharaonic guardian first. Here we go. Pharaonic guardian one, two, three, four. Can we get an amazing common maybe? I did five didn't I? I ruined it. Okay, we're looking for a good common then. Book of Moon's a good rare. Time eater. Needlewall. We finally ultra rucks and specialed. Gravekeeper, spear soldier, reasoning, royal keeper, pyramid energy, bottom of shifting sand and an owl of luck. So that was not an owl of luck that back. Okay. Legacy of darkness will do because it's been so good. There's no way there's anything good in here, right? There's no way. There's no way. If there's something else good in here. Legacy of darkness is just popping off. One, two, three, four. I not going to lie. I have high hopes for it. We have secret of the bandit. We have seven weapons. Lizard soldier, puppet magic of a dark ruler, spiritual energy settle machine, super robo lady, troop dragon, fencing mirror and a susa soldier, not the susa no soldier. Three left. Okay. This is a first dead pack. So we're going to do LO in unlimited even though it is original logo, which is pretty cool, which I think LO in for them. I mean, if it's original unlimited, it's always that logo, but still, it's still pretty cool. All right. One, two, three, four. Can we get another big pull? Secret rare, ultra rare Amazon archer. We have blind destruction. These cards are very coarse. Okay. Scroll of a witchment. We have the rock spirit gross goes to flood dreams. Lady of Salem of flames. Drugonic attack, spirit lady who was not sphere at all and the spirit message. I not the L. Thank goodness. All right, guys. Two packs left. Magic ruler.  Don't forget to subscribe to the channel. If you haven't already guys because 2024 is going to be a good year. Look how off-center these cards are. Maybe that's a good sign. Let's see if we can start off even better than we already have because this has honestly been a pretty great opening. Twin long rounds. Number two. If we get the blue eyes tuned, this will be next level. We have snail slot machine. No little brother. Interesting. Crow performance of sword. Giant Sarduloo feeds on flames magical labyrinth and we have the Toon Summon Skull. Let's go another epic ultra rare. These are some amazing packs. That's a 2002 summon skull as well or Toon Summon Skull. Unlimited, but yet amazing and actually fairly centered a little bit pushed down, but back centered. The rest of it's not too bad. Side to side. All right. Our luck's been really good. Can I ask for one more in this Invasion of Chaos first dead? I mean it's the first dead pack. Can this have a Chaos Emperor Dragon? That would be, that would be nice. Let's go. Final pack magic. Hopefully you guys have enjoyed this long video. Hopefully your popcorn was very enjoyable during the video. Here we go. One, two, three, four. Multiplication of ants. Here we go. Final pack. Terri King Salmon. Ojama Delta Hurricane. Recycle. Tower of Babel. Fenrir. Crimson Ninja. Gryven's Feather Duster and we have the Drillago. All right. Ending it with the rare. No big deal because that was a pretty amazing opening. And hope you guys enjoyed it. Happy New Year to everybody. Hope you guys have a great 2024. Shout out to Tomfoshow, Daxter, Puffins of Doom, Ernesto Dianna, America Doidster, Leo Guine, 62, Brad KK Beatz, Anantai Show, Ian Musa, Junior Marding, Robert F. Thomas McLean, Changelang and Joey Castle. Thank you guys for supporting the channel. I'll see you guys in the next one. Peace.