It is two o'clock. It is Tuesday, which means we're live It's two o'clock Tuesday Hope you're all having an amazing Week so far. It's only Tuesday but hopefully It's going good so As you guys know on Tuesdays, I do these um pours that are based on serenade Clark's Color cubes. I think last time we pulled from box one today We're gonna pull from this box, which is box two and I'm very excited. I think I'm gonna try to do a marble With whatever colors it gives me Hey Susan a JJ. How are you guys doing? Um So yeah, that's what I think I'm gonna do But you know what sometimes resin is again a resin and um You kind of just have to do what it wants to do Hopefully that's not the case What's up Lisa? Hello everyone if you could Share that I'm alive that'd be super awesome. I'm just sharing the live feed real quick What kind of sense does it make for me to ask you guys to share it and then me not share it? I guess this is like an extension of nailed it or failed it. Remember where we used to do that You had to be around a while to remember that Sorry that this is kind of boring right now so You're watching this on replay just Fast forward Till I'm mixing stuff. I am using my I sto yo Mixer today, which is super handy. Hopefully they will have the Mixer that is just like this but has the attachment Like the stand part. I don't last time I checked they Didn't have the stand available But they said they were going to so We'll find out Okay Trying to do what I can to grow our channel and Today that means stopping the live feed to share on All the places on Facebook. What's up Shannon and new Waverly? I Had a really awesome Extended conversation with Shannon today And we may even be setting up a class in new Waverly. Where is new Waverly? You may ask It's in Texas. Who knew but the rest of that just drip off Cool cool cool tight tight I'm just going to scrape the edges in the bottom of my this Bowie Also, if you're new here, hi, welcome I do have two dogs in my live work space my little humble home and one of them is almost four months old so She's a little excitable, but I'll show you pictures of her and Bowie later in the video actually when I'm going to find the colors that the box has chosen for me I may just play a puppy video for you guys. So you're not just bored out of your gourds Hey, Tim. How are you doing? Did I ever send you that resin? Hey, see Carrie. How are you doing? Alright, so everything is all mixed and cleaned and cleared and fully incorporated So I started my blog back up on my website by the way first subject matter today was color theory. I Don't know why she's whining. She just has something to say So I don't know how I'm gonna do this other than say What do I have over here?  Maybe I'll just use this exact oblique Across the top of these cards and the first The first number two that's posted and I see it. Oh my god, I got resin on this Well, I don't do the tunic don't do too yet Okay The first number two that I see come across the screen. I'll stop and that will be the color.  So the first seven I see I will stop Oh my goodness, okay, and this number is going to be a Four The first four I see I will stop and we'll pull That color Palette and then you guys will pick one two or three and I'll pull those colors and I'll just let you watch a puppy video Until I get back. Oh my goodness. How is it? So I usually don't do this but since they these are almost Identical the only difference is the blue and the green I'm gonna put one back in here So we can get some variation in color So now we're gonna do Six if it was just because of the colors I wouldn't Wouldn't have said anything but You guys Picking crazy colors today. So Now I need you guys to tell me one Two or three What palette do you want me to try to make a marble out of So one has Teals graze and is arguably not even arguable You can't even argue the fact that this is gonna be the easiest to make beautiful This one's gonna be the easiest to mess up and this one's gonna be the most vibrant So one two or three I will give you guys another 30 seconds to vote and I will tally and see which um Palate you guys have chosen so right now There are five twos five threes and One and a half ones So now it's six threes you guys have ten more seconds to throw a vote up Currently number three is in the lead followed by number two Clara you already voted a thousand times. I mean keep voting I need one new individual to choose and Cheryl has chosen three Sorry I'm kind of sorry. I'm actually Low-key just a little bit of a lot relieved because I don't know how I would have done a blue and orange Countertop so I'm gonna go pull colors and in the meantime and in between time I have this super short video of Puppies I will play for you. I won't take me long to pull these colors This is canvas playing with Rhonda's grand dog Okay colors This video is a minute and three seconds so magenta or Magneta that was easy Okay pause Look at this. Would you look at that? Okay magenta got it. Cool. That's hot pink Miss Sarah Renee Clark. I love these little cards and they are great for color inspiration Jeff and I were just talking today about doing a jellyfish. Okay, so it's it's it's fate so Would you guys call that hot pink? I don't think I would All the other ones look accurate I Yeah But hot pink now Anyways proceed This color is actually dusty pink So that's what I'm gonna pull if I have one open this board Rhonda ended up Betting me dinner if her dog one I had to buy and if my dog one She had to buy she ended up buying cuz canvas rocks And here's just This sample boards. I think Tiffany has chosen the bigger one But just so you know what those look like I have two more colors to pull and then we'll get fully started That looks like lavender, but What do I know that looks more like this color? We're gonna go with this. This is Not the color in the picture, but it's the color in the picture. I Said that wrong straight up cerulean don't have open All right, we're gonna use a custom blue that I made not too long ago so Let's get to doing artwork. I now that I have pulled these colors and quite nervous About any and all results That I may create Put this over here Put this over here and I'm coming back to YouTube so I can see what you guys are talking about Okay, sorry thing answers before, but do you know where you got the cards? So the cards were a gift from My fairy art mother Judy Howard sand, but they are by Sarah Renee Clark Sarah Renee Clark She most likely has a website you may be able to even get them on Amazon if you can I don't have them linked but I'm sure someone can help So I am about to get started. So we have our resin mixed and Because it is oh Claire got us the link before I even read it because she's amazing like that You guys have to know that it is my opinion before doing this poor That you can make almost any colors work as a countertop finish as Long as you have a translucent and an opaque white now that is Way before having actually done it. I'll know after this one if that's a true statement We'll find out together I'm not putting a lot of color in these tiny cups Nope, not putting a lot of resin in these tiny cups because they're gonna be for the colors and when I do countertop finishes Things like this I I Keep those to a minimum Hey, be sweet one two three four five one two three four five Always being kind of aggro right now Hey, what's the problem here and doing the lines on the board before applying the rest of the resin too I think that helps a bunch agreed huge Fan of underpainting with resin, but I will go over that if you haven't seen me do other Finishes I'll go over that in a minute. So first color on the palette was magenta. I'm using deep magenta by just resin It's a flat color no shimmer. It is a paste which means it is super good about just melting into the resin without any Hassell I don't worry about little particles not melting into the resin Just like that. It's good to go We give it a few more swirls just for good measure Good to be safe than sorry I'm not gonna set that back on the board Because I have color all over my hands, okay Next color on the thing was hot pink I Don't I wouldn't call that hot pink. I would call it many things other than hot pink and I Wanted to stay true to the palette. So I pulled this color. That's called dusty lavender It's brighter than it looks on camera It's not all the way bright But it's a good color. I've had this dusty lavender since I started carrying just resin and It's still workable still usable But sometimes I have to hit it with some heat Because it will separate and solidify So I'm just kind of doing that over here real quick I would love to say that I would have had this done prior to going live I don't know how it's gonna use this color, but if we're honest I'm working in the shop until minutes before we go live Not sure how we're gonna feel about this color But I always end up Liking that color best by the end of it the color that I'm like Know about that So this is also a flat color has no shimmer no sparkle And because I didn't take the time to fully mix what I have in the jar This is a little bit translucent. That's okay. Bowie So the next color on the thing Said Amethyst But the color that was next to amethyst was more of a lavender periwinkle So I'm gonna use just resin lavender It is a shimmery paste from just resin It's got like a silver Sheen to it Bamp you're supposed to be sleeping. However, I'm always excited to see you Thank you guys so much for coming in and checking out my live today and any day that you do I Wish I had words to tell you how much it means to me when you guys show up for me But I'll get sappy and cry so we're not gonna do that so this color is a cerulean cobalt that I Custom mixed for another project. So I'm gonna use it in this one If you want a color similar to this Then just order a just resin and in the notes Tell me that you want the blue from whatever today's video is Like the video date. There's a little note section in the orders Whose blue is flat it is opaque Cannot see through it No shimmer and then the last color on the thing was dark blue. This is another color. I Almost fell over custom-made. It's very much like a phthalo blue very deep It's like an indigo e phthalo e Blue so it's gonna be a little bit translucent But I'm glad that the Color swatches had a dark color Then it just helps out. So that's very much like an ultramarine or phthalo blue this Is going to be my Milky Way If you're on trouble, you don't have to go to timeout Just rest up So this is my Milky Way. It's gonna give the piece sparkle and pizzazz any time I do a countertop. There's both sparkle and pizzazz And maybe even something in between There's a little bit too much sparkle and pizzazz So I'm gonna mix just a little bit more clear in here and that should be just perfect if you've seen any of my countertop videos, you've heard me say a million times that the key to Really great like faux finish is Using Transparence translucent and opaque colors in various quantities. Oh my goodness It's like they wait till I'm live So we've mixed up in opaque white, which means you cannot see through it I'm going to do my next blog on The difference in Opacity so translucent transparent opaque Etc. But when I recently posted is on color theory, I figured I may as well just write it down since I have to give Rhonda a write-up of the Class I'm going to teach down there, which it will be on color theory How and why? Dad got it. I just dropped some white into my Magnetta That's okay. The Magnetta is so opaque and dark. They can't even tell I'm gonna change my gloves There's no bound no amount of alcohol wipe We'll be able to get that much paste off my gloves and I'll be using large gloves for the remainder of this video Because I'm out of me DMs Okay Why do I always get so nervous? When I do literally anything in front of you guys. I just want it to be good. I think that's what it is Right then so Let's get the party started. Let's do underpainting first Vampir Claire can you message Rhonda and let her know that it is Tuesday therefore I am live and I will call her back In a moment What's over here, can you see this and put that here is it visible? Okay, so let's underpaint with our darker colors Okay, so this is a piece that I poured along while back Still have it. So I thought I would Repour over it. I always do underpainting because it always looks better for my particular kind of artwork but just as Art is subjective So can be your desire to underpaint. I don't think I don't do any other underpainting colors So I'm gonna just finish out these lines. I Don't want to underpaint too much because It can still take over. I say that as I'm like fully Putting more resin down. Okay Could be finished all on its own Hey Christy, how are you doing? right so You take some opaque whites Try to be so random our translucent white that is Kind of reading as opaque. So I'm going to add some more clear That titanium sure does like to Make things opaque. Okay. I feel better about that now. Okay calm down canvas and I'm gonna put some of the Milky Way down Milky Way is gonna act as kind of a break to peekaboo What's under? The resin all right, so I've got all my underpaint resin on here.  We'll just work with it. I'm just trying to make sure there's no Open breaks of resin everything's covered. All right Everything is covered It does not look like munch right now but it will Trust the process. It's gonna pop some bubbles Further make sure that everything is coated and covered probably add more white because This has taken all the way over make more light. Did I? Oh, I didn't know if you meant right now So I'm gonna put some more white down Makes a little bit more white. That's why I always have some spare resin on the side You never know if you have to mix some more, you know All right, so let's I'm gonna Zoom you guys back to zoom you back does that? I don't think that makes sense, but hey Ronda. Sorry mr. Call Okay It's gonna use this little handheld one because it doesn't flamethrow me like the The big one of these that I have So I am just torching and tilting To make my white areas stretch out on the piece Keep in mind. This is all background noise Therefore, I'm not sure why I keep focusing in on it, but it needs adjusting therefore We're adjusting what's up cats. Oh my goodness. I just remember that I haven't messaged you back Claire you're absolutely right the Thalo Does have a mind of its own and we'll take over Just as the dark turquoise will and does so Typically I don't do Fogging and Italian drips, but this is so Not white that I may end up doing a little bit of that a little bit later Just heads up. Okay, so let's build our dirty poor cup with a cup Here's a cup. That looks like a cup What's up Laurie? How are you doing? So we're gonna start with translucent swizzle of our cobalt Some diamond dust nope Dang it Ronda you being in here made me think I was using diamond dust that is milk and some of the lavender Some opaque white in there more Milky Way and some lavender Which is mostly translucent so I added two swizzles Then some magenta. I'm gonna make the rest of my clear into Magenta nope into my whites because I'm gonna need more of them Be advised they low takes over. I Was not advised properly by myself to myself for myself I'll know for next time. No, I won't I'll forget unless you guys remind me But that's kind of like the great thing about doing videos So even if you guys aren't posting videos you should still record yourself creating a piece Because a lot of people will write the colors they use down the back of their boards, which is a great practice. However So what now, you know what colors you use but you don't know the order you laid them down in and that's Just about as important so That's just my two cents on that record yourself. Don't be shy And that way later when someone's like oh my gosh, can you do that for me? But bigger or different or whatever? You know, yeah, sure anytime And I know exactly how I did that Okay, now we have our dirty poor I'm gonna give it a swirl for interest Make those colors start to hang out with each other and I'm going to start my poor thing I'm gonna try to cover up some of these Not cute things some of the mass amounts of blue We've got enough to do a second one So we're gonna start with the translucent We're gonna layer just little swizzles of the other colors if you're new here a swizzle is a technical term Or just a little bit and make it messy. I've I just decided that that's I don't think Webster agrees But that's okay Webster doesn't have to agree a lot of times I'll layer My translucent or The Milky Way or You know just a neutral color in between. Oh, I almost just lost that I don't even know if you guys caught it. I Almost didn't catch it But I'll add other colors in between to Kind of give a break Between all the colors and have less mixing or intermingling of the colors But it's not really necessary and it doesn't fully stop the colors from Talking to each other. It's just something I do Okay Swirl for interest. I want to keep that and that break of white and I don't mind that So we'll just do a little one right here. Oh, it's way dark down there Why do the cups always look almost better than? What you were trying to do in the first place That it that could be just me. Is it me? Is it only me? It probably is and that's fine. I Love doing the ribbons Even though I'm fully aware that I'm gonna have to tilt this bad boy. How fun I just want to do a cup that runneth over That has awesome resin like that. So if I'm an alcohol rag and we can get to manipulating Whore from height Sounds good cats What's up, Lori? Okay That will take forever Let me see if I can work this flame thrower without throwing flames I'm gonna go ahead and say I'll probably throw a flame.  I don't know Okay, I'm gonna take our palette over here so I don't get it dirty really good at that And we're going to manipulate this bad boy and make it make sense I'm gonna hit it in areas where I want it to move faster because when resin is thinned out That happens from putting heat on it About to fully cover all my big breaks of white But that is okay I have to say that this may not have been a bad palette. I think I just Did too much with the underpainting and that took over and it's kind of no coming back from there And the bright side when things like that happen you can use The piece to experiment with different techniques This just looks like a very colorful melted ice cream Okay So I'll probably end up doing Some fog and fracture If I can find the gloss white I Know we have it because the only reason why we have it is to do this so it wouldn't have used it up Doing other things Maybe I have a gloss that's in one of the colors on the palette This blue is shiny It says navy Maybe we'll do this, but I feel like there's already too much blue in there So what are you guys doing after this live feed? tish is Having a video right after this one Clara can add a link and Tell you guys About her channel and what we're doing We're basically That's a flat. We're passing our viewers along Aha Found it found it and it's full all right the tilt definitely helped tilts will always help and Honestly, it looks better in person than it does on camera. I don't know if some of my other techniques Would be beneficial in this So if I decided I wanted to like swipe and get like a blended marble Could do that But I think I like Some of the crazy that happens so What do you guys think should I swipe more into the marble or sorry, there was a hair or Just let it go with what it's doing right now. That's awesome. Carrie Oh next week, we'll have a chain of videos starting with Clara's live at 415 Then Janice did I say that right then Julie then ATD and then tish at artist Haven But that's next week on Wednesday You like what's close to me. No swipe. Yeah, I think the swipe Passing us along. I caught that in a good way though. Like we're trying to help each other grow As YouTube professionals and so To do that We're informing people of what live is next in case you want to switch over to another channel after The one that you're watching which for right now currently is this one But it's a moot point till next Wednesday. Anyways Because that's when it starts. So I'm about to do the Italian drip if you don't know It's a very high-end and skilled technique. I Coined the phrase I did not come up with the technique But yeah, I'm gonna try to do it. I usually don't do successful views But if you're gonna do this being a well-ventilated space Also, don't have fresh resin and don't have hot resin this resin is still warm But I don't want you guys to have to wait until Forever To see what happens. Also, what's up happy as anyone tried the magnetic epoxy mixer just curious if they work They do if your resin is thin enough otherwise It's just gonna what happens is like pill it's dropped in the bottom and the metal plate is spinning and thus makes the Magnetic pill also spin or the pills metal and base magnetic in any case metal and magnets work to spin a pill at the bottom of a cup with resin presumably But I only know this because of my resin mixer if I stick my This is actually a good subject for me to talk about while I'm letting my resin cool off just a little bit so if I were to stick this all the way into my Bucket and turn it on and let it mix I've noticed that it only mixes the bottom portion and then I have to adjust my holder To differing heights during the mixing process for it to fully incorporate everything all the way up the bucket so While I haven't tried it Based off of the things I have tried I don't think it would be that effective Okay, so I Like this side better than this side and also this side is darker. So I'm gonna do the white over there Oh, yeah, so today is me it to and then Clara Clara Lawrence art. She does alcohol ink alcohol dyes resin magic over on her channel Clara Lawrence art and then tonight is RK three designs and and Rhonda was in here a second ago For a second So I really never do this right the key is to not have fresh resin like I currently have and Also not to put too much spray paint or too much alcohol down Both of which I have problems. I Hmm, I don't know if I want to dust on some Blue or just roll with this. I think I'm just gonna roll with this and then we'll Worry about if I want to add blue later trying to open my Okay my Little squirty bottle thing is basically just a super soaker It doesn't do any fine misting. Okay So if you haven't seen this done before This is great to give you fracturing I'm gonna zoom you in down here so you can see I'm gonna work on these two areas real quick So if you have too much spray paint down too much alcohol or your resin is too fresh your Cells that you create with the alcohol spritz are gonna open and they could close up They also could Just grow until they break so What my lady Rhonda told me is to Do big dots and then do spritzes and flicks to Open the rest of it up bearing in mind that it's Gonna keep changing as the resin opens separates settles and Etc. I think I almost always add too much spray paint and Too much alcohol and I'm sure That I do this way too soon and it's just not ready so I'm gonna let this alcohol dissipate a little bit you can tell when it's done by Looking at your surface from an angle and seeing if there's kind of a divot or a low point Where you spritz your alcohol that means there's alcohol on the surface weighing down a little bit So you need to give it time to evaporate and then you can continue manipulating it if you layer on Whole bunch of alcohol and spray paint you're not gonna get the look you're looking for unless there's a look that I'm not aware of Everyone what you're missing is every time Eric who tries this she makes a face kind of sideways mouth like Lucille ball. It's hysterical so When I just have concentration face and I'm trying to splay my fingers Evenly and when I do that I have thinking slash concentration face, which apparently looks like Lucille ball Which is fine? Looks perfect. No more alcohol. So It I mean it may look okay from afar However, let me just bring you down for a closey up a real quick It has more to the piece I agree, but Ultimately adding any layers will create dimensions and Dimension equals it looks better So even here where I didn't even have any spray paint. It's pushing my pace around Like a bully if you wanted to do the moon That will look great So because I use too much spray paint. I Had to use a lot more alcohol to push the spray paint aside and That will create these fuzzier looking cells like this So learn from my mistakes that grit that's in the middle the rest of it That I haven't done anything with is in the center and it looks like this Evelyn I'm pretty sure Rhonda waits a good like 30 40 minutes You want your resin to be settled down From all the heat all the mixing having product in it. You want it to start to relax and That point is it like 30 40 minutes depending on your ambient temperature what heat source you're using and What your working time is with the epoxy with art coat you have a lot longer open time Then with other resins Okay, should I add the navy blue Fracture should I attempt it? What are y'all's is thoughts is While you're figuring that out I'm gonna put some stuff on the piece. I always do like crazy Like fault lines fracture lines. I don't know what they're called But they're super thin super fast Micro lines and when the resin settles It'll look like just chips in your resin. You know, you can't even really see You don't go by time you go by texture It's hard for me to explain texture So I have to give like a time frame, but effectively when you can stretch this Like two inches instead of just this half to one inch right now, then you should be good to go That's just a roadside test that I pulled up from You know side of the road. Okay, I'm not gonna do that. I'll get distracted and I won't do what I was gonna do Oh, yeah Evelyn you you I think I feel like 20 minutes to be good for you in Florida But it depends on the humidity that day ultimately Okay, if you guys aren't gonna tell me I'm just gonna do it someone tell me not to do a fog with Navy or I'm gonna do it You have 15 seconds. I'm gonna clean the resin off of my camera lens And then if no one has told me not to then I'm going to and that's how I live my life That's how decisions are made unless someone tells me not to I'm gonna Do it's cool to be clear. I wouldn't have done it if you guys were like no, I don't want to cover it all I just want to kind of just bring in Some of the color here we go Why do I get so nervous? It makes no sense So what you're effectively doing when you do this technique is you are putting a liquid Pigment on top of your liquid resin and Then you're putting liquid alcohol on top of it to Disperse the paint So that you can see through it. So just think of it as like Something I've ever seen water that has a whole bunch of stuff on it be it pollen or Cranberries or lily pads and so what essentially is happening is You're using the alcohol to move What's under it? I mean what's on top of it? ultimately giving you something that should Arguably look really rad Now It's easy to do too much. It's easy to go too far. I've Arguably gone too far on this one, but we're experimenting with it Nonetheless, it definitely looks different on camera. Let me bring you guys down again Did I mess up by adding the Navy? Judy So it's doing that little loose Amoebasque star Starfish that makes no sense all this business Too fresh But it's gonna still settle and move So unless you guys tell me to dust over it with white Which I think I'm gonna hit one more area with the white that nothing to do with what we've already done G. Udy Do I have a gloss purple gloss purple spray paint cool-looking planet?  So Essentially once the propellant evaporates You're stuck with it. That's stuff that I try to soak out of my liquid Colors my floating colors See, I'm doing this over though the white we first did and it's not moving Yes, um Blossy purple See these loop spray paints. Are they gloss or well, I can't tell if it's shiny on top because we have a Working art studio that puts dust on everything. We would put money that you bought a gloss purple Found it and it's actually almost one of the colors in the thing Shannon we talked for over an hour today, and let me tell you you can do it. You've done the research You have the proper materials And now it's just putting it into action Do it All right, so that alcohol evaporated fairly quickly. So let's Do purple I'm gonna use One of my husband's stencils To be a little bit more selective of where I'm adding This spray paint So this is a stencil I want to just Not touch my piece I'm gonna do this out right here. Sounds good Ah, I want it to go Selective but let's blend this in This looks a lot more harsh on camera I promise it's not That abrasive I am using 91% isopropyl alcohol by the way. I wouldn't use anything other than 90 Well, if you've got higher then go for it, but I wouldn't use anything lower Does not work the same Don't ask me how I know It's at this point that I have considered the fact that I haven't put any Metallic in this So I have no floating anything Man that actually it doesn't look The purple looks crazy on camera, but it doesn't look that crazy in person. Thank you kim crow. Bye. See carry Then fracture lines. I don't know what you want me to do some fracture lines with goodness. I have like Fumes of resin left. Okay. What about if we picked up from the outside? I Need a bigger stick Gonna need more wax.  I bet it would I Could turn it white with no problems I just wish I had more white You guys I'm literally checking under My piece to see if I have any white that just fell out Did not Bye melody. Thanks for coming in. Thank you shinan You're so sweet christie. Thank you So I don't have any more white But I have some dirty pour Oh, he says hello but that blue This that I did a second ago actually looked the best. So I'm gonna try to Pick up tan lid. Oh, yeah. Well, it's from yesterday All right. Hi, bubba Okay, I need to put a floating something in so floating gold copper or silver You have 20 seconds Before I test your papers. Nope grade your papers copper gold silver copper gold silver I got one silver While I give you guys nope time to do that. Yep. I'm going to give you another flyover It looks a hot mess now that I'm giving you a flyover, but This bit I'm not I'm not mad at I think I need to tilt it again All right, almost everybody says silver I'm going to Running at the silver will take me just a second. I just have to run into the shop. I'm going to Apparently get sticky I'm gonna take this cap Put it under here and add some fire Do not Put fire on your piece when you have fresh fluid Very flammable alcohol on it just Let it breathe for a minute Okay, I'm going to get silver in theory. I don't know where My that is We'll find it We'll find it together even if you guys Are not over here with me Ooh Jeff just got back from cutting clear Shapes for you guys We got our little vial of silver. I'm going to put somewhere where I won't spill it If you guys are not Aware slash familiar. I always put my floating pigments in the back of a cup like this one So that I can work out the propellant That is what makes the This is essentially spray paint. That's not in an aerosol can so I'm working out the propellant which is that was a big fly And I know he's going to find his way right into my piece at least it'll be this piece and not an important one I'm working out the propellant So if I were to leave the propellant in it The lines that I want to draw into the piece and Make them thin and deliberate Uh, if I don't work out the propellant then those Lines that I draw will kind of bloom out and Not look how I want them to they'll get fatter. They'll break They'll split they'll crack and It's it's not a cute look for me therefore um I work out the propellant And then I can control it better I will be painting over this piece however At least I was able to discuss how to do an italian drip light blue and copper are Amazing together because why color theory? It tells you that since those are opposite on the color wheel That they'll work nicely next to each other however I said I'd let the viewers decide and the viewers decided silver so We're doing silver I picked up a little bit of my clear slash milky white slash has all the colors in it to mix into my Silver I didn't do a lot the more resin that you mix into it the duller duller more dull less vibrant How everyone say it it changes the Luster of your floating liquid pigment So don't put a lot in there All right, you know what we may do some silver and some copper Because the silver does look really good But I worry that it's like blending in too much Really want the floating components to stand out I mean My goodness those fault lines that we already put in there. Okay, so I know I'm doing something already, but Need you guys To see how great these very thin Lines of white Those are those little Hints of fracture lines that we put in there by Clara and it makes things look so much more real Okay, I'm gonna do a little bit of copper just so we can put them Side by side I gotta do that too lorry One day All the time Okay, so I'm gonna put a little bit of this copper on and then class will be dismissed So just like with the silver I'm gonna let some of the propellant work its way out of The pigment With this copper if I shake it you can see where it's kind of like dark where it splits. That's all propellant And so it's already turning yellow on the rim Uh, I have had people ask me why I use the bottom of a cup, but that is because There's so much propellant in this that's because usually the inside of dixie cups are lined with like a wax and that will prevent Uh, your mouthwash or whatever from soaking into the cup also will prevent Propellant see every time I tilt it down you can see the dark up here That's all propellant But it's still working. I'm gonna just I should wait but you know whatever I should wait a little longer before moving on there's still gonna be a lot of propellant in this So I'm putting a little bit extra Um Of my overflow runoff resin I'm just gonna do a roadside test and see what happens It's gonna bloom and crack, but it'll be cute on video All right Sometimes I like to go along with The design that's already happening when I use floating colors But a lot of times I just kind of make my own Little area that makes it make sense because ultimately When you're looking at a piece You want it to make sense, right? If I were to put these lines on and make them go this way It wouldn't hit your eye right it wouldn't make sense So that's kind of what I mean by make it make sense I mean Usually there's no rhyme or reason Or why resin is or isn't doing something It's just because resin Well, that's that's a lot. There's always a reason I mean there's science involved in resin. So if it's not doing something there's a reason Definitely my favorite part is the area that I fiddled with the least Shocker But that's um That's where you have to decide when to walk away which is arguably one of the harder Uh techniques there I say to learn with resin Is just Knowing when to just Walk away It's already great. It's good. It's done walk away But you know, I always find a little something that I'm like What if I just a little bit I have time it works out. I have time it does so Let's see what the Here's the resistance. I don't know if I said that right looks like Copper looks good Copper looks good So I did not let it Soak out the propellant so it broke right here and remind my broken nail So it broke right here. There's that lapse and where the floating copper is because propellant Also, oops, but it's fine And then we have some of the silver it is there. It does look really good. It's just not quite as evident as the copper Anyways, so Sarah Clark There's resin on my this Sarah Clark you win This round Lisa I do not see it I do not see a woman sitting in a chair, but yeah so I'm interested in doing a jellyfish You guys let me know if I nailed it or failed it with this palette Do you like the piece? I I did too much color Were I to do it again? Be an eighth of the color and more white I hope you guys enjoyed it. We're entertained educated or otherwise informed of something you maybe didn't know or wanted clarification on I hope you subscribe Because I mean you're here watching so Why not subscribe? If you don't know all the colors that I use today are available in my shop Which is right here Thank you, Julie Here's my shop. I expect my next shipment will be Color obsession majority of tints And then just resin no color passion will be in and then just resin but all those should be here like Within seven days My giant little baby puppy is right here. Her name's canvas. She's adorable. She's precious In my baby bow Hey, bubba You didn't want to give me attention until okay She can't even There's a good tired girl and my bowies precious always aren't you my bubba? Shannon I will get your shipment to set out to you Soon see I'm not always horrible at marble. I can make it look good That one just got away from me Anyways, you guys are amazing Please subscribe if you haven't if you're in a group and someone is looking for a resin colors or a new hobby Please send them to my site word of mouth is the best way to advertise and I cannot do it. I need you A tired dog is a good dog thousand percent you guys are amazing Uh be kind of one another because you never know what someone's going through And since my husband's asleep always remember We do tests So bowie doesn't have to and also you you guys are amazing And we love you seriously See you guys tomorrow at 6 p.m. Till then Bye


So, I will simply introduce the next speaker, who probably needs no introduction, former director of the National Human Genome Research Institute, now head of the National Institutes of Health, and clearly a major force in genomics for many years, Dr. Francis Collins. Wow, Eric, what an amazing start to an amazing day. Symposium is supposed to be a Greek drinking party, but I guess we don't get to do the drinking part, but this certainly does feel like a party to celebrate 10 years of the genome. And I guess in that regard, Eric, you must have been the appetizer, and I think I am now the soup. And then we will get on to the main dishes, which are going to be really amazing in terms of the information and the quality of the presenters, what a lineup has been arranged for today. It's really exciting to be part of this. So, in my comments, I thought I would just say a few words about where we've come from in the last 10 years, but mostly talk about where we're going with a few snapshots of the ways in which the application of genomic sequencing is already making differences in the lives of real people. And so I'll tell you a few anecdotal stories if you'll forgive me, and then I'll move on to talks about how we might begin to take a lot of these developments and move them more in the translational direction, because that is something that I think at the present time we have a special opportunity to do. Well, it has been 10 years since those covers both appeared, and now here we are to talk about what's been accomplished. As one example of the way in which the genome information has made it possible to learn more about disease, if you look at disorders with a known molecular basis, and you watch to see what's happened in terms of the numbers of those over the course of years, you can see the beginning in the mid-1990s as genome tools became more and more accessible. That began to rise dramatically, and we're now up to the space of about 4,000 of disorders whose molecular basis has been determined based upon what you can read in OMIM, just a dramatic increase in information about disease. And of course many of these are single gene Mendelian disorders. We've also come a long way in our ability to understand the genetics of complex diseases, and this is process that had its first success in terms of the genome-wide association study in 2005 with the identification of a variant in the complement factor H gene associated with macular degeneration. And then over the course of the next few years, as you can see from this diagram building up each one of these circles representing a well-validated genetic variant associated with a common complex disease, the number now over a thousand of such variants that have been discovered. Most of these with relatively modest contributions to disease risk, but pointing us towards pathways that must be involved in disease, which are exciting to contemplate in terms of their potential for developing new approaches to therapeutics. But I wouldn't say we've quite yet gotten to the point where all of this is turning out to be actionable in the average encounter between healthcare providers and patients. And this cartoon doesn't exactly give you a view of the future. First of all, they have this hard copy of the genome, which would probably not be the way you'd want to implement this kind of research.  So I want to talk a little bit about ways, though, in which we are already getting to the point of being able to do things like this, although hopefully more effectively. And again, you've already seen the famous diagram. I'll show it one more time, but I bet you'll see it again during the course of today. That is the way in which the speed in being able to determine DNA sequencing is really driving much about what we'll be talking about in terms of genomics. And that dramatic drop that even exceeded Moore's law beginning about four years ago with next-gen sequencing coming online, making it possible now to sequence a megabase of DNA for much less than a dollar 15,000-fold improvement in cost effectiveness in the course of these last 10 years. How has this then played out in terms of applications to medicine? Well, let me give you a few examples. These, some of them from the published literature, show the way in which one can now take systematic DNA sequencing, not depending upon a hunch about what gene is involved, but actually looking at the whole genome either by exon by exon or the entire sequence, and being able to identify variants that are associated with the disease in a consistent way. This is one example, kabuki syndrome, where the MLL2 gene turns out to be mutated as a cause of this disease, which was too rare with too few families to be able to map by the traditional positional cloning strategy, but now in this work done at the University of Washington is understood at the DNA level. Other speakers today, no doubt, will mention other examples of this same sort. Rick Lifton, no doubt, will tell us about ways in which this has revealed interesting examples as it comes to salt and hypertension, for instance. Just published last week, an interesting example of this done here by Bill Gaul and colleagues as part of the Undiagnosed Diseases Program. These two siblings and three other siblings that are part of the same family have had this progressive debilitating joint pain, and this really remarkable looking x-ray showing the way in which they have calcium building up in the arteries of their hands and feet, but interestingly not in their coronary arteries. These two sisters were seen here in the clinical center as part of this program, an analysis done of the affected siblings narrowed down the interval where they all seem to be homozygous, and ultimately sequencing showed a mutation in the gene Nt5e, which you can see in the diagram here, is resulting in a very low expression, almost a zero expression from that locus. Well, this is an interesting example because it not only explains what's going on in this family, it actually reveals a pathway that we didn't know about before. The Nt5e gene encodes this protein CD73, which converts AMP to adenosine, and apparently the absence of CD73 resulting in the inability to do this conversion results in calcium building up in arteries in the pattern that you saw there. So this is a new disease, not previously described, but also shedding light on a pathway that was not previously understood. My prediction would be we're going to see a lot of this because there are still more than a thousand, more like 2,000 diseases for which we know there are single genes involved, but which are rare enough that they have not yet been identified. In my own lab, I would say the availability of genetic tools to be able to investigate a very rare disease has been empowering in a way that's actually led now to clinical intervention. This is the disease Hutchinson-Gilford progeria syndrome, one of the rarest of human diseases affecting about one in eight million individuals and resulting in a dramatic form of premature aging as you can see in this affected boy. Individuals with this disease traditionally have lived only to about age 12 or 13 dying of heart attacks or strokes with a very rapidly progressive aging syndrome. It was possible using tools from the genome back now seven years ago to identify the cause of the disease, which turns out to be a single DNA-based change, and it's actually one that's rather unusual in that looking at it, you might conclude that this is a silent mutation because here's the normal sequence of laminae. Here's the mutation that you find in kids with progeria. It still codes for glycine. However, it does create a spliced donor in the middle of Exxon-11, which is not normally supposed to be there. That results then in an alternative splice that deletes the last 150 nucleotides of Exxon-11 resulting in a protein that's missing 50 amino acids. Interestingly, almost all children who have the classic form of progeria have this exact base change, and their parents are normal, so these are de novo mutations almost always in spermatogenesis in this particular nucleotide, giving rise to a very recognizable clinical phenotype. The way in which this causes disease is actually fairly clear based upon all the hard work that had previously been done on the biochemistry and cell biology of this protein called laminae, because laminae actually is synthesized and then post-translationally modified by the addition of a pharnosyl group near its carboxyterminus. But then there is a cleavage enzyme called ZIMP-C24 that actually takes off the last 18 amino acids, including that pharnosyl group, and the mature laminae is no longer tethered by that pharnosyl group to the nuclear membrane. It apparently needs that in order to zip code itself to its proper location just inside the nuclear membrane, but then it needs to be released. The mutation in progeria is such that it deletes the recognition site for ZIMP-C24. Those 50 amino acids that are missing include that recognition site, and so you end up with a protein called progerin, which is permanently pharnosylated, permanently anchored in the nuclear membrane, and which causes all manner of disruption and ultimately premature senescence of the cells. So knowing that this was the pattern worked out by others, and knowing what the problem was in progeria, we reasoned that one possible strategy, if this is a toxic protein, would be to try to cut back its amount, and that would be to use a pharnosyl transferase inhibitor to try to block this earlier step, recognizing that there are many other proteins that are also pharnosylated that will be affected. But pharnosyl transferase inhibitors had been generated by several drug companies because the famous RAS oncoprotein is also pharnosylated, and so those were available for use in a clinical trial, and these 28 kids are now more than two years into a trial with this, with preliminary data suggesting that this is actually working pretty well. This is a phenomenal kind of thing to be able to point to, seven years from gene discovery to clinical trial already two years along for such a rare disease, but perhaps that's a snapshot of where we might be able to go in the future as we get more and more information about the genetic basis of disease and about how we might connect that up with the armamentarium of targeted drugs, many of which may have been designed for other purposes, but which can be recruited for this particular application. Let me tell you another anecdotal but interesting example of how genomic analysis has led to an intervention. In this case, it's Nick, who you see here at six years old. Nick developed severe inflammatory bowel disease before his second birthday, something that looked like Crohn's disease, but obviously very early onset with multiple intestinal fistulas, unable to be fed PO, 100 plus surgeries, no diagnosis about what was going on. The folks at MCW undertook whole exome sequencing and found a mutation on the X chromosome in a gene called XIAP. Here's a gene that had previously been linked to a blood disorder, but not to intestinal problems. In the cases where it was affecting children who had a blood disorder, bone marrow transplantation had turned out to be successful. Without absolute certainty that this would work, the decision was made to proceed with a stem cell transplant that was done last summer. As of now, Nick has apparently pretty much resolved his intestinal disease completely, doing well with continued recovery. So here's an example where the sequencing led to an insight which led to an intervention which appears to have been highly successful. So genomic sequencing again connected to the clinic, albeit in a rare instance, but I think we will see more and more of this as we go along. The ClinSeq study, which you will perhaps hear a little bit more about during the courses today, a study being done here as a collaboration between the genome institute with several other institutes involved, particularly heart, lung, and blood, trying to identify ways to apply genome sequencing in a clinical setting, enrolling 1,000 volunteers, having their sequences determined to see how that correlates with their clinical phenotypes in a circumstance where they can be brought back for more extensive phenotyping depending on what is found. I can remember when this program was first proposed about three or four years ago, there was a lot of controversy about whether this was a good idea or not. The controversy now is, well, why didn't you start sooner and why didn't you enroll more people? The initial focus has been on coronary artery disease, lots of interesting discoveries. And in the panel this afternoon, you will hear from one of the participants, Rick DelSantro, about his experience, including the discovery of something pretty interesting that neither he nor we anticipated as a result of this kind of program. But I can't stop giving examples about applications of genomics to clinical medicine without touching on cancer, and Linda Chin will no doubt say much more about this this afternoon. But I do think since cancer is a disease of DNA, the fact that this effort jointly between the NCI and the NHGRI is a real flagship of the opportunity here to be able to apply this kind of approach to a comprehensive understanding of what makes a normal cell become malignant. We now have seen many developments coming out of that, obviously beginning with the first three types of cancer that were approached in the pilot phase and now an expanded effort aiming to try to characterize 20 cancer types in detail over the next four years, working as part of the International Cancer Genomics Consortium. As just one example, the work being done at Wash U on acute myeloid leukemia comes to mind, where that group has been first able to identify in the very first complete DNA sequence of a cancer. They all the changes in a genome of an individual with AML, but now expanding that to 50 patients to 150 patients, finding this recent discovery of a recurring mutation in a gene involved in making a protein which has to do with methylation. Lots of opportunities here to understand a disease for which we desperately need new ideas about ways to treat it. And I'm sure you will hear more about the applications relating to cancer during the course of today. So let me now just switch though to a broader question about are we in a best possible position to take these discoveries about rare diseases, about common diseases, about neglected diseases of the developing world, and move the fundamental knowledge that's coming forward into its application. Because that can be a very broad yawning gap sometimes, sometimes referred to as the valley of death here in my image, it's more like a river. And what do we need to do to cross a river? Well, we need to build a bridge. And so the idea here, which has been underway certainly at NIH for many years in many applications, is to invest part of our effort in taking those basic discoveries and moving them in the translational direction towards new therapeutics. Again, this is something that has been primarily thought of as an enterprise of the private sector. And the private sector has been putting huge amounts of dollars into this, as you can see by this yellow line over the course of the last 15 years. But the results have not necessarily been as gratifying as one might hope. If you look at those blue bars, these are the number of new molecular entities approved by the FDA each year. And if anything, it looks as if the success is declining despite those increased investments. On top of that, Pharma is pulling back investments in developing new therapeutics in certain areas, particularly those involving the brain. Biotechnology companies, which are a big part of the engine of discovery, are many times now struggling because of the difficulty in getting access to venture capital at a time where the economy has been not so vigorous. And venture capitalists are looking for quick wins instead of long-term investments. And this kind of work has to be considered as a long-term investment. And again, there's a big problem because the success in going from an initial idea to an FDA approved drug is truly challenging. As you can see from this diagram where you may start out with 10,000 ideas and end up with one approved drug after the course of many years. And so this means that the whole enterprise is enormously complicated and expensive. So could NIH do something more now with this deluge of discoveries about molecular basis of disease to contribute to this? Not that we're going to become a drug development company, but could we build upon the experiences already successfully carried out by NCI and NIAID and other institutes that have been in this space to try to provide a platform for this sort of drug development on a broader scale? Interesting paper that just came out this week documenting the fact that NIH does in fact have considerable experience and a track record here that something like 20 percent of truly new molecular entities with new applications over the course of the past few years have come out of public sector research initial investments followed up by commercial application. So it's not as if we don't know something about this. And in fact, we actually have a number of programs already in place that could expand this effort and perhaps provide a broader platform for drug development. And I just want to tell you briefly about a few of those. This is of course a schematic but a very oversimplified one of the way in which one goes from learning about a disease molecular cause, which is after all potentially the same as identifying a target for therapeutics and carrying that all the way through to FDA approval and even to comparative effectiveness research after that. That involves assay development, high throughput screening, a lot of medicinal chemistry, the preclinical efforts, which are sometimes called the Valley of Death, the FDA investigational new drug application, then the phase one, two, and three trials. The NIH Molecular Libraries Initiative funded now by the Common Fund, which has been in place for some five or six years provides these particular capabilities and has been used by investigators to develop more than a hundred effective probes for research. And about half of those look as if they would be promising to carry on to the next phase of preclinical application and ultimate clinical trials. A new arrival on the scene is something called TREND, the Therapeutics for Rare and Neglected Diseases Program. And this is again specifically aimed at that preclinical space and is attempting to try to deal with the fact that we have a very large need here for attention to rare diseases of which there are some 6,000 or so and only 200 have any pharmacotherapy available, but many of them have had their molecular bases uncovered in the last few years. Progeria is just one example. It also is intended to focus on those diseases that are high prevalence in low income countries but are neglected because they occur infrequently elsewhere and therefore have a relatively limited market size and therefore companies are less inspired because of economics to invest in them, although fortunately that is changing to some degree because of support from things like the Gates Foundation. But still the needs are great. So TREND was funded by the Congress currently at $24 million to enable the development of new drugs for these categories of diseases. And TREND at the moment has started off with a series of five pilot projects. TREND is being managed by the Genome Institute on behalf of NIH. One of those is a neglected disease, schistosomiasis. The other four are rare diseases, nemenpixi, hereditary inclusion body myopathy, sickle cell disease and CLL. The sickle cell example I'll just quickly tell you about because it's a nice example of how we can work collaboratively with the private sector for a disease where clearly a new approach would be most welcome. In this instance, the drug that's being studied, 5-hydroxymethyl-2-fuehrerol or AES-103, was originally discovered at Virginia Commonwealth University, picked up by a biotech company, AES-RX, but they basically have run into support problems so that they can't carry this all the way through to clinical trials without some help. TREND has partnered up with them to work on the preclinical aspects of this. You can see here the consequence of that drug, which increases the binding of sickle hemoglobin to oxygen when you add the drug, those sickle cells return to normal. This has now gone through much of the preclinical effort and is poised for IMD and potential clinical trials, which may very well be conducted at our own clinical center in the coming year or two. Just one example of the ways in which we believe the time is right for NIH to be able to make some investments, not in areas that the private sector would normally be pursuing anyway, but to de-risk projects that seem otherwise unattractive and carry them just far enough along for commercial investment to start to make sense and then hand them over, very much along the lines of what has been going on at NIH in some parts for some years, but trying to expand the platform and also use this as an opportunity to look at the process engineering of the pipeline itself. Are there more efficient ways to do this to try to increase the likelihood of success at the end? Besides the trend program, just another couple of things to mention. We have an increasingly strong relationship with the FDA to try to assist in the development of a regulatory science portfolio that would make it possible for FDA to more speedily review drugs that are put in front of them and approve those that are safe and effective. Peggy Hamburg and I have been working closely on this by the establishment of a joint leadership council between NIH and FDA to assist that process. All of this putting together is an opportunity which is now underway to try to create at NIH a new entity to be called the National Center for Advancing Translational Sciences, which will bring together the Molecular Libraries Initiative trend and RAID, which I didn't have time to tell you about the CTSAs, which are the clinical centers across the country, all 55 of them at academic centers, our FDA partnerships, the Cures Acceleration Network, if we get an appropriation for that, which we hope we will, and put that into this new center. And there's been a good deal written about this in the press. I think there's also some confusion about exactly what's intended, and it is our goal to try to clarify that as soon as with lots of input from lots of stakeholders, we have the details together. The idea, though, is that this National Center for Advancing Translational Sciences would interact closely with the clinical center, with other NIH institutes and centers that already have big investments in this area, with the FDA, with pharmaceutical companies, with biotech companies, with academic researchers, with patient advocates, with nonprofit organizations, and would provide sort of a hub of this kind of activity, which we expect will be going on also vigorously in many of the institutes, but perhaps this could be a central focus, particularly for process engineering, the enterprise. And maybe this would be a significant opportunity, then, with this deluge of discoveries of new drug targets for us to play a larger role in de-risking those efforts and making it possible for translation to happen a little bit more quickly than it currently has been. That would certainly be something I think the public would be extremely interested in. For me as the NIH Director, I think the time is right to do this. Maybe we couldn't have done this quite this vigorously a few years ago. Maybe if we wait five years from now, we would have waited a little too long. So, if you have thoughts about that or any of the other things that I've talked about, we have on our website, this is our homepage, a feedback site that you see there. Please do your blogging on our blog site as well as on the genome blog site. You're welcome to do so. I'm looking at this quite regularly to see what thoughts people have. It is, of course, a challenging moment, because we're here talking about great science all day, but we are also at a circumstance where our country is facing deficits and economic concerns. It is, for me, a source of considerable comfort and delight that we have a president who really gets it here in terms of the value of what we do here at NIH can contribute, both to human health and to a recovery of our economy. This is a quote from the State of the Union, cutting the deficit by gutting our investments in innovation and education is like lightning an overloaded airplane by removing its engine. It will make you feel like you're flying high at first, but it won't take long before you feel the impact. Well, I think it is certainly the case that what we do here is part of the engine, and I'm delighted to see this room so full of so many people who are working hard to make that engine even more efficient so the plane can fly higher and faster. It is my great privilege to have a chance at this moment in history to serve as the NIH director and to be here, to be able to celebrate with all of you 10 years of the genome, may the next 10 years be even more exciting and more productive than any of us can currently imagine. Thank you very much. We will take one question if someone's bold enough to want to ask the NIH director a question, and it's going to have to be a really good question. If I don't see anybody walk towards the microphone, go ahead. The microphone right next to you. In the spirit of festivities and back to the champagne, I do understand that the one person who can give you permission to have alcohol on campus is in fact the director. Is that true? I'm sure someone on your staff can find that out. And with that note, thank you very much. Thank you for having us. Learning things today. All right.


The results of this study suggest that the level of parental knowledge about oral health and high salivary pH levels are protective factors against dental caries in preschool children from Wara, Peru. Additionally, no association was found between body mass index and the presence of caries in five-year-old preschoolers. This article was authored by Cesar Felix Kairohas, Karina Del Roscio Santiago Nespidin, Miriam Kelly Nietzscheva-Iyadaris and others.


This 10th year of Daily Tech News show is made possible by its listeners, thanks to all of you, including DeGrasche A. Daniels, Irwinster, Ken Hayes, and our new Patron, Travis! Welcome, Travis! On this episode of DTNS, when home security cameras aren't in fact secure, what happens? Amazon will let you know if AI wrote your next favorite book and the weirdest thing that you will see in Target ever. This is the Daily Tech News for Monday, September 11th, 2023. From Studio Salon, I'm Sarah Lane. From deep in the heart of Texas, I'm Justin Robert Young. And I'm the show's producer, Roger J. All right, we are talking about all the things today. You know, the next book that you buy on Amazon might be written by AI, might not, but you're going to know. But first, before we get to any of that, let's start with the quickups. Qualcomm announced on Monday that Apple will buy its modem semiconductors for three more years. That's extending an agreement that was set to end this year. Good news for Qualcomm, because Apple is Qualcomm's largest customer, and according to Bloomberg, makes up almost a quarter of Qualcomm's overall revenue. At its 2023 Roblox Developers Conference last week, Roblox announced new AI tools to help creators make experiences more easily. The Roblox Assistant, as it's called, is an extension of previously announced features that will help build virtual assets and write code by typing in prompts to do things like generating virtual environments. An example Roblox used for this is typing, quote, I want to make a game set in ancient ruins, make the player spawned by a campfire in the ruins, add some trees for the player to chop down, end quote. Roblox also announced that it will be available on the PlayStation 4 and 5, starting in October, spooky. Ancient ruins everywhere with trees to chop down. I mean, that was only one example, but sense one. Reuters sources say Sweden-based Embracer, Embracer owns Gearbox Entertainment, is exploring a sale of Gearbox Entertainment, which is a US game developer that you might know of because it is the owner of the Tomb Raider franchise, as well as Borderlands. Well known. Back in June, Embracer announced a restructuring including studio closures, cancel projects, and layoffs, so this may be a way to further cut costs. Pretty good IP. You got to wonder where it's going to land. Instacart filed for an IPO Monday with a target of up to $9.3 billion in valuation. Instacart said it hopes to raise up to $616 million by offering 22 million shares priced between $26 and $28 each. In a move seen as unusual, some investors have agreed to buy up to $400 million worth of shares sold in the offering, which would make up almost two-thirds of the total proceeds at the top of the price range. Almost as if it's still private while going. The Wall Street Journal sources say that Metta is working on a new artificial intelligence system designed to be as powerful as OpenAI's chat GPT, or at least the company hopes so. Metta reportedly hopes its model will be ready by next year, at some point, and designed to be several times more powerful than Lama II, which you might remember is the model that released it released just two short months ago. Metta's all in on AI. And those are the quick hits. All right, let's talk about writing books and who should. After complaints from groups, such as the Author's Guild, but not the only group, Amazon has started requiring writers who want to sell books through Amazon's Ebrook program to disclose if their work includes artificial intelligence material. The Author's Guild says the new regulations posted last week are a welcome first step towards keeping a handle on AI-generated books on the platform, saying that it thanks, quote, the Amazon team for taking our concerns into account and enacting this important step towards ensuring transparency and accountability for AI-generated content. Boy, Justin, if all the guilds and the, you know, big ol' conglomerates could work as nicely as these two have. But how do we feel about AI-generated book content in general? I'm not sure how much I would care if it was a good book, but I think disclosure is probably the right call. Well, here's the bigger problem for Amazon and ebooks. And first, let's understand their scenario before we delve into what AI does to it. Amazon is the unquestioned king of this market. Not only do they have the biggest library, they have a relationship with customers that they have built for as long as Amazon has been a company, and ebook readers are voracious. These are sometimes multiple book a day readers that are largely also consumers to Amazon by way of their Kindle products. All that being said, part of what makes that relationship strong is Amazon's recommendation engine. When Amazon recommends something, ebook consumers very often take them up on it. What Amazon does not want is a infinite flooding of their market by way of AI writing, things that are not necessarily great, but are gameable to a point where it will sell X amount of copies and people can essentially make money by chumming up the waters for ebooks. One might say that it's already hit elements of saturation up till now. Imagine what happens when infinite books happen into that store infinitely. And so because of that, Amazon has actually been pretty punitive about fully AI generated books for a while now. And in fact, to my knowledge, they still don't allow fully AI generated books. Right. And we're living in the world of 2023 for which AI is very helpful for writing. And you can understand that if you're an author and you're writing at the speed of some of these ebook authors, maybe a little help here and again, even if it's just for helping out the story or grammar, you might want to use AI. And so essentially what they want to do is just continue to monitor and make people disclose certain things because eventually we're going to get to a point where these AI models are good enough that they can rip out books that are good for the readers. And when that happens, Amazon has a whole new different problem on their hands. 100%. And you know, never been a novel fiction or film fiction publisher myself. I can say, if it's good, it's good. Who cares? Now, if you're an author, you don't necessarily feel at all the same way that I do. When I think about Amazon in general and the idea of AI and, you know, maybe promoting products that aren't that great and, you know, fake reviews and just sort of a gamification of the system in general, I think that's a lot harder, at least for me, as somebody who buys things and by and large, the same things over and over on Amazon.  But if I, you know, get burned once, I won't come back. But when you're an author, you know, there's so much more at stake, right?  It's not just that people will say that was a bad book, it's that that's a bad author. So sure, I guess you could change your name and, you know, game the system that much farther, but only to a certain point. Well, we often with any kind of future technology tend to think that the future is just the present but slightly larger. And so all the examples that you gave were essentially just making the lives of people that already game systems easier, of which it will almost assuredly do. But there are already safeguards for that kind of behavior. What I really think is going to be existentially cataclysmic for the relationships of authors who have found the ebook store to be a lifeline for middle class writers. And the future of AI is going to be the point where they need to decide, am I an AI prompt engineer that sows things together, or maybe even doesn't, because the token limit will get so high? Or am I still going to be writing and hand crafting these things?  Before we move on, just to note, the US Copyright Office again rejected copyright protection for art created using AI, the specific case was a request by artist Jason M. Allen, which was denied due to a copyright covering an award winning image that he created with the generative AI system mid journey. Allen had argued I put in over 600 prompts. This was definitely me as a human's work. The US Copyright Office did not agree. All right, Justin, let's talk about everyone's worst nightmare. Well, all the smart people that listen to this show, I'm sure you might have some of these friends of yours that think that you're being over dramatic about privacy. Well, I want you to find them. And I want you to tell them to their face or via text the following story Friday, some why security camera owners noted on Reddit that they were able to see webcam feeds that weren't their own. A wise spokesperson tells the Verge that this was indeed an error and was due to a web caching issue noting that the paging question was quote currently under maintenance and that quote, we are working on this and we'll update you when it's available again. Yeah, so after the Verge published the story originally wise spokesperson Dave Crosby told the publication quote, this was a web caching caching issue and is now resolved for about 30 minutes this afternoon, a small number of users who used a web browser to log into their camera on view.wise.com. That's W I Z E may have seen cameras of other users who may also have been logged in through view.wise.com during that time frame. This issue did not affect the wise app or users that did not log into view.wise.com during that time period. Okay, well, this is definitely the company saying small number of users, many of you, you know, are using apps or just weren't active during this time. But it just takes the one just takes the one. Well, you know, this gets to, I think, a natural point that we were going to eventually land at after two decades of extraordinarily cheap manufacturing. And I don't mean to say that that's a negative thing. In fact, I want it to be a positive thing that as we created web services and hardware in a match that is more and more affordable. Number one, more people can understand the benefits that technology can give them. But we've also grown faster than I think our expectation for security and reputation of companies should be. I foresee a world where, you know, Apple has spent a lot of time, love or hate them, Apple spent a lot of time saying security is a priority for us. We are going to eschew money on advertising so we can protect your security. We are going to make big public fights and lines in the sand with the government based on the idea that we will have a secure device for you that matters to us, especially as you are going to pay a higher price for their products. Wise, for example, and I have a wise scale, so everybody will be able to know that I weighed in at 167 pounds this morning. And probably even the trend line of where my body fat percentage is going. 167, look at you, trim man. I mean, hey, the body fat percentage is going in the wrong direction. All that aside, this is something for which I bought because it was cheap and not necessarily cheap, but mid-budget. I can see a world where reputation is really going to matter and it's not just going to matter based on hacks or on mistakes like this. It's going to be based on the hierarchy and the decision that they have made from an organizational level on up on how to protect this data because that's going to matter a lot more going forward than simply the ability to get a cheap camera or get a cheap light bulb or get a cheap scale. That's always going to be available, but I do think it's going to become more of a common talking point, how serious they're taking care of your data. Yeah, I'm not, I know our audience would know, but I'm not sure how much the average wise user of a variety of products that are designed to be private, unless you want them to be shared with other people. How many people are going to be outraged over this? When I saw this story, I was like, I mean, this is the worst case scenario, absolute worst case scenario for any company that is supposed to let you be able to check in on your house or check in on your pets or your family members or whatever.  And somehow someone else is like, I saw your mom in your living room in her underwear. And it doesn't even have to be like, ooh, I saw something that's really sensitive. That's not the point. The point is that you have an expectation that something like this would not happen. A web caching issue, you know, the company didn't do it on purpose, but that is a really big fail. And yeah, I mean, I wouldn't buy a wise camera after this. It's an organizational thing. And that's something that when I say that people are going to be more aware of it, I would expect it to be mentioned in places like Wirecutter or something like that. Very public facing, consumer friendly elements. If you're going to talk about trade offs, it's not just going to be a hardware thing. It will also be, hey, this company has a history of not securing data. Well, what has a history of securing our hearts and minds is video games. Yeah, yeah. If you want to know what Tom Merritt thinks about video games, especially video games of the past, you should watch the latest Tom's top five, the show where Tom breaks down the five top things he thinks you need to know about technology. And the latest episode Tom lists the top five oddball video game consoles ever made from triangle shaped consoles to the one that induces nausea. Hmm, I don't know. Fun for some. Learn about all of them at youtube.com slash daily tech news show. All right, Justin, let's talk about the DMA, that is the European Union's Digital Markets Act that is the moment we've all been waiting for, set to impose strict rules on big tech companies that will have to provide interoperability to let users communicate with each other using different apps. Meta owned WhatsApp in the news today, because it is considered a gatekeeper by the DMA, thus must comply with the DMA. And the latest WhatsApp beta for Android <IP_ADDRESS> update shows that even though sort of it's a big nothing right now, at least for people who code can see, ah, WhatsApp is already working on solutions for new regulations. Although what's about six months to do so, what the idea eventually will be is, let's say I send you something, Justin, using the signal app, you're a WhatsApp user, I am not, I would be able to send you that message and our ability. So thoughts here, you know, the EU is always doing something crazy, right? Can I be an old man here, Sarah? You're gonna, you're gonna, I know, I just performatively ask for permission. I'm gonna do it. Do we really know you must run over you because that's another old man thing to do is to run over people after asking a rhetorical question. Do we really want these apps to be communicating with each other? Because I do. Why? Well, because that would mean less work on my end.  But that would be cool. I mean, but these brands mean something to me. My messages app are for friends and family and people who wrote down my number the one time that I on a dare published it on the internet. The signal is all my security friends and a few of my more paranoid family members. Telegram and WhatsApp are by and large international friends of mine that I have been lucky enough to make. And I like that. I go to different digital neighborhoods. I have different conversations. If everything became one big slosh, then I wouldn't care about them in the way that I care about these conversations now. So I'm sure that this is probably a shifting opinion. And maybe Gen Z wants everything to be in one big pile. But for me, I like, you know, I'm going to channel the offspring. You got to keep them separated. Well, well, I don't think you're going to not in the EU anyway, unless you want some some pretty hefty fines. I mean, this, I know what you're saying. And I totally agree with you. Like my Facebook Messenger crew, and they're lovely. If anyone's out there, love, love you.  My Telegram people are a little bit different. My WeChat people, boy, are they different? And that but that doesn't really say anything about the companies. It says something about the people who are using this stuff.   That's what I, I think as a user, I get out of this.  And now you must fail and, you know, start playing nicely with others. Well, I think it's the EU making work for themselves and making decisions, whether or not the customer base really wants it. That's the other thing is that all these things are free by and large. Aside from, you know, Apple's Messenger app, which obviously you need to have an Apple device. So there is a gate there that you have to pay to enter. In general, these are all apps that if you have a phone, you can download them, you can create different accounts for each of them. I just, I don't see the customer need for it because for my consumer drive does not want it. If these apps wanted to work together, then I think they would find a reason to do it. I don't know. I like being able to separate my conversations into different apps. Yeah.  Or your grandfather. I got you.  They're along gone. But somebody in my life who is who is not super, you know, tech savvy for me to kind of set up something for them and say here, all you have to do is hang out in one place. That's great. But that's actually not what the European Union cares about in the sense that we're not thinking about the untech savvy people in the world. Yeah, I don't know. This feels like an application of other EU law that I don't know if it fits here. But, you know, maybe we can set up a little telegram group complaining about EU regulations and then eventually we'll be able to infect every other app. I would prefer signal, Justin, but okay. You got it. Let's let's do that. All right. I'm just going to read this next description about a product from Target, US national chain, beloved love target, quote, inspired by the most influential gaming console of its time. This collector building set celebrates the legacy of the Xbox 360 jump back in with a fully buildable light up console and controller. The console opens to reveal a disk drive and other Easter eggs place the Halo three themed disk inside to activate the motherboard adult builders take note completing the set unlocks the ultimate achievement. Okay, sounds kind of fun question question. Would you know that this is not in fact an Xbox 360 if you bought it because it costs the same amount as an Xbox 360 more or less. This is a remarkable moment in history where adults totally run the toy market. Kids don't want toys aside from really, really young ones. They want them less and less. They want screen time. They want to interact with their Roblox virtual assistant so they can make a game featuring ruins and three trees where you spawn next to the campfire. That's what they want. And so the toy market having existed for oh so many years have realized that the people that are buying their stuff are adults, adults who want to remember the time that they were children. And guess what? There's an entire generation that are collecting big boy and girl paychecks that are ready to rebuild among their first consoles the Xbox 360. So for them, I'm sure it is great. They're going to have a really, really good time. And I hope the ultimate achievement is a red ring of death. Well, okay, so when I first saw this, this, this item, the ultimate achievement, I was like, Oh, and then it works. And it's an Xbox 360. And I actually sent this around. This is like, you know, a couple of days ago, you know, to friends of mine, I was like, am I dumb or am I missing something here? And they were like, no, man, this is like Lego stuff. This is not Xbox 360. No.  I don't think he mad. I think that they know exactly what they're doing. And as Roger is putting in our chat here, pre orders are sold out for this. Oh, yeah. So it is already extraordinarily popular.  Hey, you know, the snow days are right around the corner, everybody, you get that you get that build that.  And so like I went back when I got to a certain buying power, I just bought old iPod iPods. I have no idea what I'm going to do with them. I always like a fancy world where I'll make a little art installation with them. I have no idea. I just like to remember that time that I own those iPods. I bought one and then I started mentioning that I wanted like, I imagine like 25 or something. People started sending me their old iPods. And so now I have probably 10 or 11. Oh, you know what? Installation time. That'll be fun. I know. I know. Yeah. But hey, if anybody either has bought the Xbox 360 kit, the mod, the mod set, or really, really, really has a great thought about why this is so fun, even though it won't play any actual games. Do send us an email feedback at dailytechnewshow.com. We would love to know more. Speaking of emails, Kirill wrote in about our combo last Thursday. That was around a BMW scrapping its heated seat subscription model saying no one liked that and we are not going to do that anymore. Knock it off. Yeah. But Kirill said, this is kind of like software licenses, right? He says, do you remember the days when software came on multiple CDs or DVDs and then you had to enter a license key to unlock some of the features? Let's say you have a disc with home, professional, and enterprise versions of Windows. You can't say, but the enterprise version is already on the disc. Why can't I use it? Same thing with maybe Adobe, Kirill products, where they may give you a disc with all of their products, but your license may unlock only some of them. Kirill says, maybe BMW is considering itself a software company in this regard, spending lots of time and money in research and development to create a product, now licensing to others the right to use some or all of those features. It's not a bad analogy, but hardware matters psychologically differently in the minds of the consumer. And that's where I think you find the pushback, especially at a luxury status symbol item like BMW. When you are spending BMW money, you want to feel like a BMW owner. You don't want to feel like a middle-class BMW owner who has a cold butt. Yeah, yeah. I get what you're going with here, Kirill. And there are definitely some comparisons to be had, but yeah, when you're like, but the software to heat the seats is already installed in this car that I am sitting in right now and I pay monthly for, you know, it's a tough sell. And it's like, if I wanted to save money, I could buy a tricked out luxury Hyundai for probably less than what you paid for the BMW and your butt would be toasty warm because they don't do that. Yeah. Or even cool. Oh, you know, the cars, we have the cool ones. Delightful. An absolute delight. Makes you want to wear shorts again in a car. Well, just remember, young, thank you whether you wear shorts or not for being with us today. Let folks know where they can keep up with your latest. Like John Stockton. They're way past mid-thigh. Ladies and gentlemen, you have one thing to do if you have not already done it. And that's listen to the season premiere of Know a Little More. On this season of Know a Little More, we are going to dive into every little nook and cranny of the mother of all demos. 1968, demonstrating much of the technology that we use in our modern world, including hypertext, the mouse, video conferencing. Why did it take over a decade for these technologies to go mainstream? We go piece by piece, including in the premiere, the demo itself, the fact that the mother of all demos literally gave birth to the Apple, Google and Microsoft demos that we know and love today. It's Know a Little More with Tom Merritt. Well, we're so happy to have you on the show with us.  Do stick around for the extended show, Good Day, Internet. Would you sign up for a credit card from a video game company? You might already sign up for credit card versus, you know, depending on certain platforms. So we're going to discuss Xbox's latest move to broaden its brand to credit cards. But just a reminder, you can get your show live Monday through Friday at 4 p.m. Eastern. That is 2,800 at UTC. And you can find out more at dailytechnewshow.com slash live. We're back again tomorrow. Kind of a ho-hum day. Wunderlust, Apple announcement. I'm just kidding. It's going to be a big one. The Snobboist team will be joining us. Nico Monford and Terence Gaines will be joining us. Don't miss it. Talk to you then.


Hey guys, Ellie Hart here from T.C. Helicon, and today we get to hang out with Paul and Jenny! Hi! Paul and Jenny are DJs at my favorite radio station, the Zone at 91.3. And normally they're interviewing me, and this time I get to interview them! This is great! So we are being on this side of things now, but I'm into it, okay? It's a trip. I know, I've been really getting used to being on the other side of the camera. And I gotta say, I like being in front of the camera more than behind the camera. We're doing great! Thank you. So we thought it'd be really fun to ask you guys if you could give some advice, because you have a fantastic program that really highlights local upcoming emerging talents. You guys call that the Band of the Month. And I got to be one of those ones, and that was how I met these fine folks. And it's been really great for my career with my band, and it's given us honestly a really great following in our hometown here. And what would you guys recommend for people that are wanting to start getting radio play? How do you approach that? Is this really daunting as a musician? Yeah, it can be daunting, but the thing is that we're all just human beings, and we're all in the industry together. We all want to help each other out, and that's something that we do have to remember in radio. And I think community is so important, and promoting local talent is so important. And it's great that we're doing that here at the radio station as well, because we have so much good talent. And it's really nice to see and be a part of, you know, finding that talent, or them coming to us and then watching them grow and move on. Like we're see Jesse Roper out there, you're on this stage as well. It's amazing to see, but just approaching people in a human way, whether it's an email or like reaching out in person, and just making sure that they know each other, and that you're just kind of being aware of each other, and just helping each other out that way, I think. It's really important. It's been such a good program for us, too. It's so beneficial. It's so symbiotic the way that, you know, it's like we play a band on the radio, and then maybe a few more people go to their show, and then they're plugging us, and then maybe a few of those people who weren't listening to us, now they're listening to us. It's just like it builds and builds and builds. This is a really great cycle. And then the more people in town that hear local people on the radio think, like, oh, that could be me. And so they practice a few more hours. They work that a little bit extra harder to have that attainable goal to get there, and it just builds and builds and builds. And it's what's laid a really nice foundation between support and talent, hearing the sound that we have such a stacked local scene, and that's where we can play so many local bands on a stage this size. Exactly. I also find talking to bands who have gone through the program as well, because, you know, maybe they're doing a show and they need an opening act or whatever it may be. You know, that's a great way to reach out as well and kind of get started.