Welcome to our all-day movie workshop. Good to see you again. We have a movie coming up today that not many of us have seen, so this is going to be exciting. So for those who are just joining us new today, I can just let you know how it's going to flow. So we can start with the movie with David, and then afterwards we'll have a 10-minute break. Then we have breakout rooms where you can share any emotions or your experiences with the movie. Then we'll have a longer 45-minute break, and then we'll have a closing session with me with questions and answers. So I'll pass it over to you now, David. Thanks, Pete. Welcome. Welcome, everyone. Glad you can be with me. You're in for a real treat today. I never actually thought I'd ever show a movie like this, but Jesus is in charge, and I am happy to follow whatever Jesus wants. So we have a rather odd movie today, but Jesus was telling me, he says, I assure you this is for teaching purposes. I need to teach through contrast, and so this is an unusual movie, but I will guarantee you, you probably have never seen any movie like it. Even those of you who watch movies like movies and you watch a lot of movies, you probably will just have a smile on your face when you see this movie because you'll be like, well, wait a minute, is this really a movie? Is this even a movie? But I think Jesus knows what he's doing here, so we're going to trust Jesus with this one to give us a good setup and a good commentary through the movie. This one is so deep. I don't know. I might just have to come back around later in the afternoon and join Pete from questions and answers because this could get lively. I think this could get very lively today. I wouldn't want to miss out on all the fun. So, well, last night, Jesus asked me to Google the word satire. I Googled the word satire and I grabbed a quick definition of satire, which was the use of humor, irony, exaggeration, or ridicule to expose stupidity or vices. I just laughed so hard at the definition that I thought that sounds like a lot of fun because what would Jesus call stupidity and vices? He would say ego beliefs are stupidity and vices. And most of them are unconscious.  I said, yeah, that's a good word for this movie. This movie is definitely satire. And there's been some pretty interesting movies we've watched. I mean, over the years, there's been some amazing books and movies. And before I was starting today's gathering, the two that came to mind that might be helpful for us to have in mind. One was Louis Carroll, Alice in Wonderland. Is everyone familiar with Alice in Wonderland? She goes down the rabbit hole. She goes down the rabbit hole. And things are very different when she gets down the rabbit hole. There's the Mad Hatter and the proportions are different and the world that Alice perceives when she goes down that rabbit hole is extremely different than the world that she was familiar with and the world she was accustomed to. It's a little bit like that with the matrix, you know, when we first saw the matrix when it came out in 1999, you know, it was kind of fascinating when Neo and Trinity first go into the matrix. And that brought in the element of simulation like the matrix was a computer generated world that was generated by the machines. And it was used for the purpose of enslavement to make the mind a prisoner. And we go, we were taken into the movie the matrix because it was very fascinating it was very philosophical but it was it started to bring to us this idea that what if the world that we perceive is a simulation what if it's a, it's a matrix if what if it's make believe and it has a purpose to keep us from knowing who we truly are as a child of God is a perfect child of God. And while the matrix came out in 1999. I would say, nowadays, there's a lot of scientists even philosophers and scientists that actually now believe that the perceptual world is some kind of simulation, although the scientist. Elon Musk, he would tell you yeah the world's a simulation, but, but none of the scientists really can tell you how the simulation got here, or who's pulling the strings on the simulation. A lot of them think maybe it's a future higher intelligence a future race a future species that's playing with the earthlings in the simulation called daily life on planet Earth. In any case, we have some very interesting philosophical ideas and, and we've shown a lot of movies and the movie watchers guide to enlightenment that deal with this idea of a simulation or a matrix and how do you escape from it. Especially is if it's a dream, but you've forgotten that you're dreaming and now you're taking the dream to be reality. And that's one of the deep questions in philosophy is how, how would a loving spirit or a loving God. Why would a loving God create a simulation that had pain and suffering war disease death. Why would this world come from love. How could this world come from love. So with a course in miracles obviously Jesus is telling us yes the world is a simulation.  As light as a child of God is a spirit, then it's going to take forgiveness. And Jesus tells us in the course that it will take mind training but he is telling us that our major problem is perception of linear time that in heaven there is no time there is no linear time. And, and there, there is no past and future it's just the present moment or the holy instant is the gateway to eternity. And it seems to be quite an ingenious trick this world. It seems to be a very ingenious trick because what we perceive through the five senses and what Jesus is calling perception. He does tell us in the course that ultimately, we must realize that all perception is unnecessary. So, so perception is the veil that was drawn over the light of truth. And we have to learn how not to judge the veil in order to release the veil and experience the light of truth directly. So, I think first thing I will do is what I do often every week on these Saturdays is I will, I'm going to go over a couple of the themes that you voted on because that's how we got this movie. You voted on the themes. And early on in the week, I started to look at the poll, and we started to have a couple front runners in our poll at the beginning of the week and that's when Jesus gave me this movie. I just left and left and left. I just thought this is to use a quote from John Denver far out. This is far out. We are going far out this this movie is radical. So basically what you voted on the number one vote getter for the week was making the peace of God my one goal. That's the number one vote getter was 75 votes. And then second is let all things be exactly as they are, which, which is a reference I believe it's.  Those two as the top two, I just was like, Oh, okay Jesus you're going to have to show me because I do not have a clue what, what to use to to help us realize we need to make the peace of God our one goal and let all things be exactly as they are. Second one, which came in second by one by two votes with 73 votes. That actually is is also in the Bible. In the Bible. It says all things work together for those who love the Lord. That's a quote to direct quote from the Bible. And in a course of miracles Jesus says all things work together for good. There are no exceptions, except in the ego's judgment. So that must mean that everything that we're perceiving is working together for our good for our highest good, even if we're not aware of it. Everything without exception is part of a design plan of awakening. Everything without exception is has a purpose behind it. That means nothing is at random. That means there's no such thing as luck. That means there's no such thing as good fortune and bad fortune. If all things work together for good. Then where's the good and the bad. It says all things work together for good. So that takes us on a deep dive. That's got to be the deepest dive ever when we start to realize that we're going for a state of mind, a perspective that can look upon the world and experience all things working together for good. Put a smile on your face. No doubt that state of mind that perspective is of the Holy Spirit and Jesus and that will put a smile on your face. Now, I've done a lot of teachings over the last 36 years but actually I do like to talk about hypotheticals. It doesn't use the word I don't believe in the course but a hypothetical is simply something that is occurring as if it's real or as if it's happening so I think a hypothetical could be described as as anything that seems real. It actually is not occurring, not even occurring.  And when I looked at the course I really got excited about the teachings that Jesus was offering because I could see that he was saying that your perception of linear time is simply the reflection. If the separation had occurred as if separation from God was real, then the perception of linear time would be the outcome as if the separation could occur. And basically there's a part in the in the clarification of terms where where Jesus says in the clarification of terms and the manual for teachers he said is described as if it has two parts and he puts as if in italics. So he's putting it in italics because the mind doesn't really have two parts. There's only the mind of God and and the mind of Christ and that's the reality that's what light is. But the mind is described for this course as in mind training as if it has two parts spirit and ego. So that's called like right mind and wrong mind in the course of miracles but it's not reality that's just a metaphor describing the belief in separation. So, the more I studied the course what Jesus was teaching me he said well, let's talk about basic cause and effects. God is the cause and Christ is the effect. Oh, okay. And he said and cause and effect are together. That's why Jesus said the father and I are one. And when we say I am as God created me we're basically acknowledging a spiritual fact that God the cause and Christ, the spirit effect that the creator and the creation are actually one cause and effect are one in spirit. And that's what heaven is. So basically all you have to do is realize that cause and effect are together and have never been separate that God and Christ are not separate. It's impossible for an effect of God to leave God and go into a world of make believe, go down the rabbit hole go into the matrix, go into time and space and make up a different identity a time identity. That's impossible. And that's what Jesus discovered is that's impossible you can't leave God, you cannot leave the creator. It's a wild fantasy. It's fiction. It's make believe to believe you can exist apart from your divine creator and happily Jesus realized I and and God, we are a one we are the one the same spirit. Now, in terms of this world with the belief in separation cause and effect are split off it's the belief that the effect can leave leave the cause, and then they get split off and turned around. So it seems as if the world is causative and your mind is at the effect or mercy of the world. How does that play out in daily life. You make me said. The day is so hot. I'm so hot because the temperature is so hot. Or the belief that you could catch a disease or coven. The belief that anything in time and space can cause you to be upset in some way is in a good example of cause and effect split off and turned around. Now your mind is at the mercy of something external to itself. Jesus knows this is impossible. That's why he could heal the sick raise the dead. Walk on water ascend, you know he he he was a miracle worker because he simply got his cause and effect correct in his mind. He realized he was a perfect effect of a perfect cause. And that perception was not a fact. That's why things that Jesus seemed to say and do seem to be not of this world. They seem to be other worldly. How could he heal the sick and raise the dead. You know that that is not a common occurrence in the world. So, so basically our movie today is basically giving us a chance to start to realize that everything that we perceive is just the result of our, our beliefs and our preferences and our desires. So the world that we perceive is just a private world with private perceptions of people places and things. And this world is an attempt to get rid of something to project something that the mind doesn't want. It doesn't want it's got guilt from believing it's separated from God and now it's trying to see that guilt acted out as if there's something external causing the guilt. But there is nothing external causing the guilt. It's just forgetting the true cause effect relationship. God is the creator and I am the effect of God. I am an effect of a perfect creator. That's what the miracle comes from. That's what the miracle derives from. So, now we have seen movies like with the matrix, we matrix was kind of a futuristic movie where the machines had evolved so far that the humans and the machines got into a fight for for survival. And the machines seem to take over for the humans to make the human slaves and then there was a war, and the sky was scorched to try to shut off the sun, because the machines operated on solar power. That's a short synopsis of the matrix. Well, what what we're seeing is that was a futuristic look, and we were all fascinated to go with with Neo on that journey to try to escape the matrix. And, and yet, when we look at this world. There are so many things that have been just accepted assumed to be real assumed to be true that for the human being every day seems to be reacting and responding to external stimuli. We seem to see people, men and women, we see families, we see mountains and oceans, we see countries, we see cars and highways and streets and cities. And Jesus assures us in the course he said the real world or the happy dream has nothing to do with the world that you see. You're just seeing a simulation that was made up by the ego. And it's not hard for us to, to, to see that because where do you think war disease competition scarcity, strife pain suffering where do you think they come from they're generated by the ego, they're generated by the ego. When you see this world, it's a world of chaos. It's a world of fragmented perception. Is it satisfying. No, this world is not satisfying our mind will never be content with the fragmented world, when it was created by God to be perfect in the kingdom of heaven. So you can see the seeming fall from grace is what we're dealing with here we're dealing with a correction, we're dealing with a correction in our perception. Now, when we look at the world, we, we seem to see a pastor history. But it depends on who you talk to, to describe that history because it's very subjective. I would say the whole world is subjective it's all based on preferences and desires. That's why no two people see the same world is because the entire world is a projection of false beliefs of preferences and desires.  Now, with this movie today, this, I would say this is a comedy. I would say, I have shown on these Saturdays I've shown documentaries before. But when I found this movie, the way it was described on the internet, it was called a mockumentary. This is I'm showing the first mockumentary. I've ever shown it's kind of mocking the human race. It's it's kind of mocking the human race. It's mocking perception. And why do we want a movie that's mocking perception is because Jesus is having a belly left. He absolutely loves mockumentaries because anything that pokes fun at false perception has to be helpful. This has to be helpful than waking us up, you know, we're going to wake up with some humor here. So the matrix wasn't exactly a comedy. Even Alice in Wonderland, I would not describe that as a comedy, but Jesus Christ is giving us a mockumentary a movie that's going to poke fun at the human condition. And he wants to be here with us to assure us that this what we're perceiving is not reality. So don't take it so seriously. Remember to laugh at, at the human condition, because that's how you forgive it. If you take it seriously, then you're not going to laugh at it, you're, you're going to feel guilty about it, you're going to feel bad.  I assure you Jesus does not take the human condition seriously. I assure you that, that the angels laugh a lot. I mean, a lot. They, everybody thinks they just fly around with wings and they look pretty and everything but they laugh a lot I know, I know that from direct experience. They, they seemingly never stop laughing with me. Whenever I have taken anything serious, there's a whole legion of angels laughing. And I'm, I'm not usually going what's so funny. What's so funny about this. And they're like that will show you. Okay, show me today we're going to be shown, we're going to be shown. So, but instead of, instead of going into the future like the matrix this movie is taking us back and it's, it's showing as kind of an alternate projection some of you have heard the term parallel universes is anybody ever heard the term parallel universes. Okay. The one thing about parallel universes that makes it funny. The one thing is that they're all happening at the same time. That's, that's really the mindbender that that it's not just parallel it's it's multi seemingly multi universes all occurring at the same time. And if any of you study quantum physics this is what the quantum field is it's basically, it's basically the, the physical universe, being completely connected and all happening at the same time. That's why the early quantum physicists like Albert Einstein. When they, when they did something to one particle, and then another particle reacted immediately to what they did to one particle but the other particle was hundreds of thousands of miles apart from the first particle. That's when the quantum physicists started shaking their head like, Oh, now we really don't know what's going on, because how if we touch one particle does it seem to simultaneously affect another particle that is many, many, many hundreds of thousands of miles away. It's because it's all connected it's all simultaneous. Even quantum physicists, you know, that's a tough idea. Simultaneity is a tough idea for a scientist. It's a tough idea for anyone on earth. What do you mean it's all. What about past lives and future lives now it's all simultaneous. And that's why everything is connected is because there is no such thing as linear time. Jesus tells us in the course that the ego invented linear time past present and future. The construct of the ego and the ego is trying Jesus says to force continuity on to this strange construct of past, present and future force continuity. Of course our natural nature as a pure mind and as a spirit that's where the continuity is our continuity is in God, of course, it's not in time. Now, what is so great about the movie today is it's not taking us to a future scenario kind of like the matrix did this is actually going to take us back to 1953. The David wasn't even born in 1953, but some of you might remember the year 1953. I don't have no recollection of it. But what's what the scenario is is this is going to be like a spin on the world from a different perspective, and the spin of this movie is that in 1953. Some of you have heard from the Bible about Mother Mary and her virgin birth when she had her son, Jesus. Well, in 1953 in this particular spin of the time space universe. And there are going to be more than just one virgin birth, of course, I think even the one with Jesus was just a symbol, but, but there are going to be more than one version burst in fact it's going to become common place. So that's an interesting idea. That's kind of being interjected into our symbol today. Another thing is is that the women are only going to be having females. Women getting pregnant, without intercourse, without the typical things that happen with a pregnancy and then having female children. So that is our, that's going to be our parallel, parallel universe for teaching purposes. It's going to be a lot of females coming here. We have females who will not need a man to get pregnant and then just have females for children. So we're going to see it move over time starting around 1953 into a very, very, very female world. And I see some of you already smiling. Some of you are looking at looking like it's about time. It's about time. We had a movie like that. Now, what's going to be helpful is you're going to get a different perspective on a different perception of a world of things that are familiar in the world that you see will change will be will be different. Basically, I asked Jesus if there was a prayer that we could say from his course before we watch this, this world of this very, very female world. And basically, he gave me a prayer from some workbook lesson number 131. And this is our prayer. I asked to see a different world and think a different kind of thought from those I made. The world I seek, I did not make alone. The thoughts I want to think are not my own. That's from workbook lesson 131. The purpose of this movie for us is to put the peace of God as our first goal. So we're not looking for an outcome in the world. We're turning our mind now and we're giving it back to Jesus and the Holy Spirit and we're saying, help me find peace. Help me find that state of mind that is the peace of God. That is our goal. We are asking and praying for the peace of God. I did find a section here too that said, how can the peace of God be recognized. God's peace is recognized at first by just one thing. In every way, it is totally unlike all previous experiences. It calls to mind nothing that went before. It brings with it no past associations. It is a new thing entirely. There is a contrast, yes, between this thing and all the past, but strangely it is not a contrast of true differences. The past just slips away and in its place is everlasting quiet. Only that. The contrast first perceived has merely gone quiet has reached to cover everything. So what Jesus is saying is to have the peace of God, you have to literally let go of all your judgments of the past. And I would say all your judgments of the future, because the future is just a different version of the same thing, the past, like lesson number seven workbook I see only the past. I'm just asking Jesus to take us into a state of mind that is prior to judgment, that is prior to male female, that is prior to life and death, that is, or birth and death, that is prior to hot and cold, prior to fast and slow, prior to success and failure. And prior to anything that our five senses can show us we're asking Jesus to help us go so deep with him deep deep inside, we go deeper inside so that we can see the world and new from a completely new perspective. And that was one of the things that I liked about this movie. It says, you know, sometimes a satire can be used as an alternative history that helps helps us step outside of ourselves and see the world from a different perspective. And that is the goal of this movie and our use of the movie today we want to see the world, the entire world from a completely different perspective, not an egoic perspective, not a human perspective we want to see the world from an entirely new perspective. We want to be so willing to have the Holy Spirit show us a new bright sparkling world. That's free of judgment. In the course of miracles. Jesus says, without judgment are all things equally acceptable. And the context for what we're doing today. Could be said that I would say we could all go to that part of. He says you have elected to be in time, rather than eternity. He says you have elected to be in time, rather than eternity, and therefore believe you are in time. Yet, your election is both free and alterable. You do not belong in time. Your place is only in eternity. Where God himself placed you forever. So that's the context. We need a movie that's going to show us an alternate perception. And when we're tempted to judge this alternate perception of a world ruled by females. I mean, I mean rule. We are going to be asked not to judge this positively or negatively, but to just accept all things exactly as they are. How else can we be free of the idea of sacrifice. How else can we be free of the idea of loss. Why would we think we could reach heaven while we still were struggling with gender issues. While we still had these thoughts rolling through our mind. Men are this way women are this way. The angels left, because the angels ultimately know that that men and women are concepts that the ego made up dualistic concepts to keep us from knowing the oneness of of heaven. And it's the same with masculine and feminine, you know, we may have a tendency to value certain things and we call them masculine we call them feminine, but in heaven, there are no such distinctions. Everyone is the same because we all share the same spirit. Once we look at relationships between men and women, immediately complexity enters. You may have no notice that if you if you think of relationships in terms of men and women or men and men or women and women or whatever configuration you want to use in there. There is enormous complexity. And then Jesus comes to remind us, you cannot enter into real relationships with any of God's children, unless you love them all equally. Love is not special. Love as God loves. You see the bar is way way way beyond trying to figure out interpersonal relationships. Now in a course of miracles Jesus is not denying the belief in in those relationships. He's calling them special relationships. He's basically saying I'll work with you in your mind to help you free your mind from these crazy concepts and ideas, because it's just the concepts that are bringing you misery. But you cannot awaken from the misery until you first admit that you're miserable. So, before we start today, we have to, we have to first come to an admission to come to Jesus and Holy Spirit and say, the perception of the world that I've had of history of my ambitions for the future. What needs to change in the world for the world to be better a better place. All my ideas about making the world better. I have to admit, have made me miserable. Because I have succeeded in none of them. I mean we've tried certainly of all of us have tried. We've tried to make the world a better place, like Michael Jackson told us to do, heal the world make it a better place we tried Michael, we tried Michael but it didn't work. Now, what Jesus is saying in the course is he's saying, seek not to change the world, seek rather to change your mind about the world. See, he's telling us, give it up. It's futile. If you're trying to improve your partner, stop it. You will never improve your partner. If you're trying to improve your neighbor your country, you know, your community. No, no, no, no, not a not a not a you will not succeed. But you can change your thinking and therefore you can change your mind. You can change your perspective on this world. What happens if you're so accustomed to the world where you actually believe that men are went men and women are women. What, how is Jesus going to reach you if you believe that men are men and women are women. This movie will help. This movie will definitely help if you believe men are men and women are women. Maybe at the end of this movie you'll be like, hmm. Hey Jesus I'm open. You've got my attention now. But if you've been mesmerized if you've been hypnotized into believing that the world is a certain way. I mean, I know for years I've been I traveled to 44 countries I go stay in people's homes. We have these beautiful talks breakfast talks lunch dinner. So some people they have told me well you know I don't like the world. And I say what don't you like about it and they say well, it's a world of inequality. It's a world of competition. It's a world of struggle and fighting, and I don't like it. They said anything else that you don't like at least I don't like society. I don't like governments. I don't like cultures. I don't like certain things about cultures. And they don't like the history of this planet culturally. I said what what don't you like about it well again it's inequality. They say it's a patriarchal system. And that's got a shift, you know, we have to somehow find a way to change the world, so that it's more equal. But Jesus again is telling us no seek not to change the world seek rather to change your mind about the world you'll find the equality in your mind with the Holy Spirit. And that's where the equality is. You see, it's a state of mind. It's not something that you can measure in terms of form. It's it's treating people with kindness with love respect, genuine love and respect. So, as we look at this world we're going to see a much different spin on the world. And I just tell you as we move along in this movie I think you're just going to be laughing and laughing and laughing because with the majority in democracy's majority rules and and we're going to see with with every birth from 1952 with without many exceptions being a female birth. We're going to see a world that is shifting from a male female world a world of two genders and to coming into a world of basically one gender. And, and the way they portray it is just is beautiful they really this is a Canadian filmmaker who really came up with a good idea. And then he really did a good job with this movie, because the more you watch it the more you seem to perceive a very different planet. The configurations of people on the planet are very, very, very different from what the configurations seem to be. And Jesus is saying I need you I need to use this contrast because you have blindly accepted what you're perceiving to be the truth. And I need to show you some contrast experiences. So to get you out of that bubble to pull the blinders away. You're perceiving the world through the blinders of the ego and we need to pull those blinders away and just get you thinking outside the box a little bit. So that's what Jesus wants us to do today he's just saying, please, just join with me and think outside the box a little bit don't, don't judge it. Don't try to judge it as positive or negative right or wrong but just start to say maybe I don't have all the, the ability to judge at all. Maybe I never was intended to judge this world, maybe the world is just a projection of my, my judgments, my judgment thoughts. He reminds us in the course projection makes perception, the world you see is what you gave it. Nothing more than that. But though it is no more than that. Therefore, to you it is important. It is the witness to your state of mind, the outside picture of an inward condition. As a man thinketh, so does he perceive. Therefore, seek not to change the world, but choose to change your mind about the world. Perception is a result and not a cause. And that is why order of difficulty in miracles is meaningless. Everything looked upon with vision is healed and holy. He's, he's calling us to open up to our Christ vision to our, to our spiritual lie to our, our higher way of looking at the world.  The only way you can laugh at it is not judging. But as soon as you judge it, then you try to make part of it real. You try to have a tiny partial vision you put the blinders on when you judge. And when you don't judge it, it actually is a beautiful, it's a beautiful world. Not beautiful in the way that the past has taught you but beautiful in a way that the present moment shows you seeing the world and new with fresh eyes. So that's our setup for today. And I will give you just a little bit of the characters because it's helpful to zoom in to the characters. Basically our main characters for this movie are there is Andrew. And Andrew is a man. He's 37 years old. And he is the youngest male on the planet.   There are no teenage boys or 20s. He's 37 years old and he is the youngest male on earth at the stage of the movie. Okay. Now that means there are some older men around, but there are no men younger than Andrew. He's 37. Okay, he's, he's the young one. He's the infant of the males. He's 37. And he is working for he's employed by a family of women of course. So he's the maid. I know some of you, I see Diana, instead of the Latin American tradition where there's a lot of the female maids. No, this is, this is the youngest male on the planet and he's like the maid for the women.  So Iris and Tara have employed Andrew as their maid.   And, and Andrew is the help. He's the helper. He's hired help for that in a world which is predominantly females.  And this, this started back in 1953. So here we are in modern times. So it has evolved. The women have populated since 1953, and not needing men. They have populated and populated and, and it's a, it's a bit different world, there, there isn't the same kind of issues on the world, there's no war on the planet. It's a planet of women.   But you know how it's, it's when you have a group of women that are living in the same household they all get in the same menstrual cycles. So basically, the world is like one giant sorority house. All the women have their menstrual cycles, synchronized, and there they are and, and basically that's, that's the status quo. I find it's, it's helpful for lifting your mind from the world that you perceive right now. Because the more you get into the movie, you know, you start to feel yourself open up into another perception. It's so different. It's so different from what seems to be the everyday quote standard or normal perception. And this is how the Holy Spirit works the Holy Spirit has to introduce contrast to take your mind beyond fragmented perception entirely. You have to start to the, in fact, there's 10 characteristics of a teacher of God that Jesus talks about in his manual for teachers and all of you know the first ones trust the second ones honesty, but the final trait of a teacher of God is number 10 is open mindedness, open mindedness and that's what we're going for today. We're just going to say all right Jesus, take me and take me towards open mindedness. Help me start to just be able to watch this movie and watch this world and go. Okay, let all things be exactly as they are. That's, that's for my mind. That's for my, my own healing. Okay, I think that's good. That's a pretty good setup. I will pop in during the movie and this is going to be a lively day because you aren't going to see a movie like this very often. This is, this is a treat. It's, it's not just ladies night. It's ladies day. It's ladies day every day. Okay, enjoy the movie. I'll pop in. See you soon.


Hi there. I'm going to share in the screencast how to duplicate activities and resources in your Moodle course. Now the ideal time to get started doing this process is at the beginning of your course development, but you can implement this strategy I'm going to show you anytime. It's really useful if you want to have, let's say for example, all of the weekly assignments in your course are going to be worth the same points with all the same behaviors from one week to the next to the next to the next really consistently so you don't miss the settings on an individual one. So first of all in your Moodle course click on that gear in the upper right and go down to turn editing on. Let's start in your week one section. Click the add an activity or resource. Let's select assignment for this. But like I said earlier, this process can be used in any of the activity types and the resource types and click add. Let's just say this is going to be the week one assignment. In the description field you're going to type in or paste in or maybe even a link to a Google Doc just indicating the basic instructions for your students. You want to try to make this as generic as possible so that you can have just minor edits from subsequent iterations of this assignment and I'll show you what that means here in a few minutes. Let's go ahead and click expand all over here and we'll just take a quick tour through the settings. So on this first implementation of this activity, you want to make a detailed tour through all the settings to make sure that this first one from which you're going to duplicate the others is set to how you want all the others to behave. So if you want your students to be able to input online text in your assignment for example, keep this checked or uncheck it if you like and or this file submission. This would be a good setup right here for a paper submission assignment.  So let's pretend I'm just interested in having my students submit PDF files. Let's just say, perfect. I can scroll on down and again I'm just taking a detailed tour of all the settings if I want to implement TARDEN or not I can choose that here. Let's say each of my assignments is going to be 10 points. If I have previously set up grade book categories, that's going to show up in here. There's going to be in the assignments, scrolling on down. Let's say when activity completion, which is that little checkbox that we'll show as checked when you have implemented a grade. You can keep that checked or not. I'm going to go and uncheck that for this. And I'm just going to click save and return to course at the bottom. So let's say I'm ready to bring to life the week two assignment that's going to go down here. All I have to do to the right side of the week one assignment is click the edit, drop down menu, down to duplicate. This is where the magic happens. And with the little move feature on the left side of this, I can drag that down to the week two section. Now let's just click edit again on that one now to edit settings. And if I have indicated week one up here, I'll just call this the week two one. And any instructions in here, like I said earlier, if they're generic enough, like say the week one assignment might be regarding chapters one through three in your textbook. And now the week two might be chapters four through five, let's say. Make your changes in the description. And then all these settings, make sure if you've indicated availability, that's going to also be copied over. So change those in the second iteration if you want. But all on down the line here, all those settings from the first one will be duplicated into the second one and just click save and return to course. And from here I think you can see what to do next when you're ready for week three assignment. Just like that. Now of course, every activity that we bring into the course via this method that has a grade potential attached to it, that also represented in the grade book by a column there. And so there's a column for each of these in the grade book right now. There'll be one for the week three, four, five, et cetera. Pretty slick. And you'll find a lot of other uses for this technique I showed you here. So I hope you enjoyed it. It's pretty easy, huh? Have a great day.


And I have always been interested in seeing these things with my own eyes. I wanted to get a sense of the experience that many of you go through every day. And for some time I have been telling to senior leaders in the congress that I want to go and see what it is like. But every time they would make some excuse or the other. Maybe my security people didn't want me to go or whatever it is. So this morning I went into the sea early morning with my brothers.  But I want to tell you what this experience is like. From the moment the boat left the shore, to the moment the boat came back, every single force was trying to fight my brothers. They take the entire risk. They put their entire labour. They fight the sea. And somebody else gets the profit. And this morning we went, we threw the net, we threw the net back out and there was one squid in it. So the whole investment that was put into the boats, into the journey, the petrol. Within one minute we saw that there was no return.  And then the net came back empty. So I saw with my own eyes your experience.  You cannot buy an engine beyond a certain size. The boat cannot be maintained over here, it has to be maintained somewhere else.  I am not saying that everything should be done for your benefit. But some sense of fairness has to be there. The fishermen told me if they come one hour late, they don't get the same price that they would get if they came one hour before. I asked them do you have insurance? He says no people do not have insurance. So what I wanted to tell you here in this meeting is that I have a sense of what you are dealing with. And now when a fisherman comes to me and says I am struggling, I understand a little bit more about what you are going through. Of course, I will never understand exactly your reality. I only pull the net for one day. So I understand and I respect what you are doing. But I would say even stronger, I admire what you are doing. Many times we will eat some fish but we will not know the hard work behind how that fish got fish. So today it was very interesting immediately after we went fishing they cooked some fish on the boat. So for the first time I realized directly with my own eyes the difficulty to get the fish on the plate. And I also want to tell you that I want to work with you to make your life easier. I might not be able to resolve all your problems but I can certainly stand with you and work with you to resolve as many of them as we can. Before I left the boat I asked the fisherman, what do your children do? And he said my children do not want to be fishermen. Because it's too hard, too difficult, too risky. Anyway I have come here more to listen to you than to tell you what I think. So whoever would like to now speak please feel free to do so. They can't see over there. So I think the question is what would we like to do for the fisherman community? I work quite a lot with farmers issues. And now they've got these three new farm bills. And the idea is to destroy the agricultural system of India. Just like our farmers farm the land, you farm the sea. The farmers have their ministry in Delhi. You don't have a ministry in Delhi. No one speaks for you in Delhi. So the first thing I would like to do is have a ministry dedicated to the fishermen of our country. So that your issues can be defended and protected across the country. Of course there are many details. I would like to try and understand how we can make it easier for you, simpler for you. Today the petrol price internationally is dropping, but in India the petrol and diesel price is rising. This money is being taken out of your pockets and given to two or three businessmen in India. I would like to make sure that more of this money comes into your pocket. And I would certainly look into what the Kerala government is doing with regards to these trolleys that they are building. I don't like an unfair situation. I am for competition, but not unfair competition. So there should be a level playing field for everybody. There they can see. Last night we were working with three or three and a half months. We were working for three or three and a half months and we couldn't get a single rupee. What he is saying is for three and a half months, they want auction to be done here. We are talking about if you want to auction the fish in the harbor, five-person condition has to be given to the government. The government of Kerala has issued the ordinance by which a new condition has to be stipulated, by which five-person commission is required. They want to abolish their commission because it is the right of the fishermen, say their freedom. We are currently in the process of making the manifesto of the UDF. We are having consultations with different groups, different communities about what they want in the manifesto. Yesterday in the UDF meeting and in the meeting afterwards of the congress party, I said that we need to have a dedicated fisherman's manifesto. So, I would like the fishermen of Kerala and the congress party and the UDF to have a conversation over the next two-three weeks and decide exactly what they want in the manifesto. So, I would like the fishermen of Kerala and the congress party and the UDF to have a conversation over the next two-three weeks and decide exactly what the fisherman want in the UDF manifesto. So, I would like the fishermen of Kerala and the congress party and the UDF to have a conversation over the next two-three weeks and decide exactly what they want in the manifesto. If you want the tax withdrawn, if you want the 5% tax withdrawn, put it in our manifesto and it will be done. My guarantee to you is whatever is in that manifesto, we will deliver to you. I want the manifesto to be your expression. On one page of that manifesto, I want the voice of fishermen to be there. So I would implore you please have the conversation with the UDF leaders. I don't want a situation where what we are committing to you is not clear. I don't want it to be vague and flexible. I want it to be crystal clear. So it is easy for us to deliver. You should know that if we support the UDF in this election, this is what the UDF is going to give us. You should know that if you support the UDF in this election, this is what the UDF is going to give us. Consider the manifesto to be a platform of your desires, of your dreams. It is your instrument. This is what the UDF is going to give to the UDF. We are not using the road. In the way of road access, the government is buying 18 rupees from India. In the way of road access, the government is buying 18 rupees from India. He is saying that they are not using the road, they are using petrol, diesel, carousel, etc. 18 rupees are being charged from them. If the government comes into power, they will be doing something in this regard. So they are just using this. So what will be our assurance if the UDF is to pass? All these things, please put them in the manifesto. Do what you want us to do. We will put it in the manifesto. And my guarantee is that if there is a line in the manifesto, we will deliver that line to you. Rajji, very good morning. I have two questions to you. You have not seen a single fish when you have done the fishing. The reason behind that, it was Mr. Narasimha Rao's foreign policy to the Globalization. He has made a policy for the foreign tourists. Now the Kerala government is also doing in line with the same policy. So what is your action plan to remove this policy and support the fishing? Second thing, now, majorly in this place, three places, like Covil Totem, Porto Vallam, and Dehra Vita. The fishermen are asked to move out from their own place. They have not been given any sea wall. They are not protected. The government is asking them to go out of that area. Do you think that will they able to move if they move out from the coastal area? See, some of these issues are complicated issues. And they are issues that the state leaders of Kerala will have to assess and look into. My role is to make sure that you get a fair plan fee. My role is to ensure that you are not being treated unfairly. My role is to ensure that you are not being treated unfairly. My role is to ensure that you are not being treated unfairly. And in general, I think that you should be protected and your risk should be reduced. On the issue of globalization, corona has changed the entire world. And we are going into a new paradigm. And we have to prepare ourselves for a new paradigm. And we have to prepare ourselves for a new paradigm. And we have to prepare ourselves for a new paradigm. And we have to prepare ourselves for a new paradigm. I think the income disparity, the difference between rich and poor in India has become too big. Some of this is a direct consequence of globalization. But there are also advantages to globalization. Today I asked the fishermen, how did they work before they had a sonar? They know what sonar is. Sonar is the machine with which they can see the fish. And they said it was very difficult. They had a GPS to tell them exactly where they are. These are all outcomes of globalization. We have to be clever with globalization. We have to take advantage of it, where it helps us. And minimize the disadvantages of it. We have identified 11 crisis problems which I have given in the paper. So I think you must go through it and pass it over to the UDF leaders to be included in the manifesto. There is a question, fishermen are the ones who are getting the maximum foreign exchange for India. But nobody considers them in that way. What are you going to do for the welfare of the children of the fisher community? Well I think education is central to the future of the children of our community. And also if our community is to educate its people, finances are required. In the last Lok Sabha election, we had a concept called Nyaay. Where we would guarantee that every poor person gets 72,000 rupees a year in the bank account. In our manifesto, we are developing a version of Nyaay. Where every single poor person in Kerala will get in their bank account money. That will make their life easier and it will make it easier for them to educate them. And we must also make education accessible to our fishermen by helping them with loans, by helping them with access to our income. These are some of the things that we are planning to do when we come to Kerala. I think one thing I would say is we should have a dedicated conversation with our fishermen. One thing I would like to say is we should have a dedicated conversation with our fishermen. Where across the state we talk to our fishermen, brothers and sisters and ask them exactly what they need, what protection they need, what support they need. And have on a piece of paper the four or five most important things that they expect us to do for them. I will tell the people who are running the manifesto to do this. No, it's fine. So, thank you very much for coming here this morning. Thank you. Thank you. Thank you. Thank you. Thank you. Thank you. Thank you. Thank you. Thank you. Thank you. So, thank you. Please come. Thank you. Dindu Krishnan Dindu Krishnan Dindu Krishnan Dindu Krishnan


If we were to ask ordinary people in 1998 what is the role of this European central bank, most of them would say, well it's just another central bank. If we were to ask them now, every single one of them would know the answer. Why? Because ECB managed to communicate its purpose and monetary policy correctly throughout the years past. Since 1998, the ECB has developed and evolved with its main goal to always have remained the same, to maintain price stability. In order to always achieve that goal, ECB makes decisions based upon the monetary policy. But how does the ECB remain transparent and accountable when communicating these decisions? Accountability and transparency are two sides of the same Eurocoin. Being accountable means that the bank is responsible for its actions and its decisions when at the same time its monetary policy is proven to be effective. Because ECB was initially established with a master's degree, it needs to act accordingly. Being transparent means to be open and clear about the information of its purpose, strategy and procedure. It means being able to explain and justify the state of the economy, but also the logic behind its decisions to both the stockholders and the public. Transparency and accountability means following three principles, honesty, clarity and common understanding. But how do these two values remain preserved and secured throughout crisis and hardships? The answer is basically between two simple communication verbs, to inform and to dialogue. Informing the European Union, the stockholders and the general public, affects hugely the prosperity of the world's economy. The predictability of the economy charts defines every economic and business movement on our planet. Imagine being a well-established businessman or an investor. Imagine having to invest millions of Euros on a service or a product. Sounds great having all this amount of money in your hands, right? But let me give you the worst-case scenario. What would you do if you had no idea about the condition of the economy around the world? What choice would you make? How would you make it? Thankfully, the ECB has taken some precautions to prevent that and keep the economy predictable to some extent by publishing the annual report and the report of every meeting. It also organizes speeches in the parliament delivered by the bank's representatives to inform both the government and the public. Moving on to the second communication verb, which is to dialogue, ECB policy is based on equality and our human right to express our opinion publicly. Transparency is the key to overall credibility in the wrong run. While still in the shorter run, it ensures the smooth and efficient transmission of monetary policy. At the same time, it is in the bank's own interest to communicate as it contributes remarkably to the efficiency of its policies because it helps financial markets and the public predict the economy. The central bank needs to be accountable and transparent. That will contribute to an effective communication and to remain independent and democratic.


What's going on guys, it's your boy DPJ here today with another Destiny video and today we will continue on with the info we see from Game Informer and their cover of the Rise of Iron. Now a lot of info came out of this, some of which I have already covered which you guys will find on my channel, I covered about the new exotics and also covered about the new gear as well as how you will get the Iron Lords gear when the Rise of Iron releases. Today I want to talk about something which well at the moment sounds incredible, but we are in fact yet to see exactly how it works, all we can go on is what's said by Game Informer and that is a new way to customise your guardian and your weapons. But before we get into the video if you guys could drop a like I would appreciate the support as it really helps out. Now this new way of customisation is called ornamentation and this is what Game Informer says about these ornaments. To further support customisation every class item that has ever shown up in Destiny is returning into circulation with the exception of items from previous raids. Class items once again colour match with your chosen shader, those cloaks, buns and marks add yet another way to set your hero apart. That in my opinion is absolutely epic, there are some amazing old school cloaks from my hunter which I just don't wear because they drop my light level to such a way I just can't do shit, but now they are all coming back into circulation that's absolutely epic. Beyond returning elements visual customisation of your guardian also has a brand new component called ornamentation. Ornaments are meant to offer expanded ways to set your guardian apart and they affect several of the new legendary armor sets as well as exotic weapons. Bungie stated they introduced Chroma in April but that was only about illumination. Bungie stated they wanted to evolve that system into something that allowed not just colour changes but to have geometry changes as well. For instance you may end up having huge new pauldrons or a fur trim on your weapon or armor set. I just don't change the functional options of an item but instead layer on a skin that changes its appearance in both subtle and dramatic ways. These prestige options are applied to items one at a time and during my experiments, still causing gaming for me here, during my experiments I could change them back and forth at will. Already imposing raid armor suddenly gains new light and colour effects. Most exotics like the infective and Monte Carlo have new colours and visual effects. One weapon gaming former stated they saw was visually transformed from its normal appearance into an ultra sleek golden age form reminiscent of the popular sleetha simulant weapon. Like the recent introduction of Chroma, ornaments provide yet another rabbit to be chased in the name of shaping your guardian's persona. Many of the armor ornament sets are only rewarded through top tier play. For instance only flawless trials runs provide the ornaments necessary to tweak your trials armor pieces. Other ornaments including some of the exotic weapon ornaments and the iron lords armor set are dropped from radiant treasures. Like sterling treasures before them these packs can be obtained through both designate in game activities and micro transaction purchases. So guys we are basically getting weapon skins for exotics as well as ways to set apart a lot of the new legendary armor sets. At the moment I don't believe there to be any images of weapons or armours with these ornaments on. But there are a lot of new weapon images in the gaming former article which ain't covered by what we know. A lot of these new weapons and their new designs could indeed be what we have learnt today. All I know is I cannot wait to see more. Weapon skins in general are something we've wanted to see for quite a while. Ways to customise your weapon beyond trauma is a step in the right direction in my opinion. And obviously new designs will be added down the line by Bungie. Me for one I cannot wait to learn more about this. But guys tell me what you think about this down below in that comments section. Tell me what you expect.  But even though the idea of ornaments dropping which can be applied to weapons to make them stand out and make your garden stand apart is definitely a great great thing. But like I said guys tell me what you think about this down below in that comments section. If you guys are new to my channel subscribe for daily destiny. Do hit that like button I do appreciate the support and I will catch you guys on that next one. Peace out until next time. Peace.


I hope that's not the whole talk, but so I want to thank the meeting organizers for this opportunity to speak to you today on what is becoming a very intriguing story in the colorectal and endometrial cancer. As you've heard from several of the other speakers during this symposium, we of us who are studying mutations kind of have a Goldilocks principle where we don't want too few mutations because we can't discern what's broken, but on the other hand if we have too many mutations the background rates go way up and it's then very difficult to discern which mutations are causing a disease. So this is going to be a story about the ultra high mutation rate where it's very difficult to tell from one patient to another which are the driver genes, but the polymerase that may be underlying that is turning out to be very interesting. So okay, so I'll pick up where we had left off with the marker paper of the colorectal cancer where we're showing mutation frequencies here. The blue line are the frequencies of non-synonymous mutations and you can see that most of the patients have a low rate between one and ten mutations per megabase. They're microsatellite stable and then there's another group of patients that are recognized as hypermutated that have also microsatellite instability as indicated down on the panel below. The microsatellite instability is associated with a very high rate of MLH1 silencing through CPG Island methylation and what we observed was that there is a small group of patients with the highest mutation rates. These are mutation rates greater than a hundred per megabase that did not have microsatellite instability and did not have MLH1 silencing apparent and in fact the MLH1 track up here shows that they weren't even mutated in MLH1 and interestingly they all had mutations in the polymerase E and so polymerase E is one of the two major replicative enzymes that replicates the genome at S phase and this came to our attention and we dubbed these ultramutated. This came to our attention when we looked at all of the mismatch repair systems across these patients and what's shown here are the different groupings of DNA repair genes. The green are mutation frequencies in patients with greater than 100 mutations per megabase the ultramutated. The red are the hyper mutated microsatellite in stable and the blue are bars represent the low mutation rate patients and generally you can see that all of the gene or many of the genes are increasing in mutation frequency as you go to these ultra high mutation rate. However interestingly not all genes show that trend in particular this blue bar here is p53 whose mutation rate actually goes down as you go to higher mutation frequency. So interestingly in the polymerases there was a single gene that was mutated in all of them and however a single gene mutated in 100% where n equals 6 is not all that much to write home about. But when we looked at the location of those mutations in the polymerase we saw that they clustered mainly in the exonuclease domain. Now all of these mutations are only from the ultra mutated patients and so there are more than six here and that's because some of these patients are mutated multiple times and what was really intriguing was not only the clustering in the exonuclease domain but the fact that S459F had been seen twice and as this was coming together a paper came out from Japan by Yoshida and colleagues where they had discovered in a single patient the F367S mutation and so which had also been seen in this study. So this recurrence at these two sites in such a small data set seemed strongly suggestive but again with n equals 6 we had a very hard cell here. So we had about 300 more patients to go in the colorectal project overall and so we went back to sequencing hoping that we would see more of these and so let me just mention why Yoshida referred to this in the title of that paper as the proofreading function. These polymerases have been studied for the last two or three decades in great detail and this shows the results of some experiments with the T4 polymerase and in the exonuclease domain of this polymerase mutations are known to cause a very high rate of mutation and this mutator phenotype as it's become called has been seen in bacteria now in yeast it's been studied extensively. Interestingly mutations in the polymerase domain over here sometimes actually improve the fidelity of the polymerase and it's thought that the polymerase has to slow down when the polymerase domain is mutated and that lets the exonuclease domain operate more efficiently. So what you have here is something like a modern day word processor where you're typing in Microsoft Word and you mistype a letter and push the space bar and the error is corrected. So we can also look at recent experiments in mice where the exonuclease domain has been mutated and knocked out in mice.  Here is a polymerase E homozygous mutant compared to the wild type.  The pole D1 which is the sister polymerase of pole E also has a very high rate of death. These are also dying of cancer and elsewhere in this study they showed that these mice had a mutator phenotype. So with all this together we were very excited about this and went on sequencing and this now shows the results of sequencing across 500 patients in colorectal cancer. And you can see that we have replicated mutations in sites we saw previously at P286R with a variety of different amino acids at that position, V411411L. Here is the F367S which we haven't seen again and then the S459F which has not replicated. So our colleagues at Memorial Sloan Kettering who are working on this with us also worked on the endometrial paper or the endometrial project where they also have microsatellite in stable patients with hypermutator phenotypes and so they were able to quickly confirm that this same phenomenon occurs in the endometrial cancer. So here you see replication of P286R and V411L across their patients and these patients have the same hypermutated, ultra mutated phenotype. In addition, these ultra mutated patients show a very dramatic skewing in the relative frequencies of CA mutation relative to the hyper and the low mutation rate microsatellite in stable. So we don't know for sure the origin of this yet. The mutations that we see in the patients are a combination of a mistake by the polymerase and whatever replication, sorry, whatever repair processes are going on. So we don't know for sure whether this just results in a results from a inefficient repair of this kind of mutation. However, there are some early suggestions now from further work by Nils and Nicky at Memorial Sloan Kettering that different mutation hotspots lead to slightly different frequencies of these mutations, suggesting that it might be arising from the enzyme itself. So this is then the scorecard in colorectal cancer and so what this shows that across our microsatellite stable low mutation rate patients of which there are 412 in colorectal cancer, only four of them have mutations in pole E. None of those are in the exonuclease domain and none at the recurrent sites. In the hypermutated, we actually get 19 mutations in the hypermutated, three in the exonuclease domain, but none of those in the recurrent sites and this suggests that these are just passenger mutations resulting from the hypermutated phenotype and then in the ultramutated across the whole molecule we have 23 mutations which is more than the number of patients because there are multiple mutations per patient. 100% in the exonuclease domain and about 80% in the recurrent sites. The phenomenon looks very similar in endometrial except that in endometrial the frequency of microsatellite in stable is higher and the frequency of the ultramutated is correspondingly higher, but we come down to very close to 80% of the patients with mutation in the recurrent sites. So this shows that there is actually detectable similarity between T4 phage and human pole E. These systems are for DNA replication was pretty much solved once in evolutionary history and is now recognizably similar across all most species and not only the polymerases but the other components of the replication machinery. So this enables us to easily map the mutation locations onto a X-ray crystallography structure of T4 polymerase and the gray domain here is the polymerase domain. You can see the double helical DNA moving through here. This purple ish is the exonuclease domain and the red and yellow are amino acids that are mutated in our data set and so they're all clustering in this one area of the exonuclease domain. So earlier I mentioned that there are actually two polymerases. One is pole E and the other is pole D. These have been known for decades and over the last five or six years studies in yeast where yeast origins of replication are well known have knocked out the exonuclease domain and looking at the skewed ratios of mutation arising from pole E mutants in yeast, researchers have been able to show that the pole E is functions on replication of the leading strand and likewise experiments with mutation in pole D show that pole D functions on the lagging strand. So there's this asymmetry in function of these two polymerases. So there's been a recently published collection of origins of replication in human and so Nils Weinholt looked at the mutation skewing in our polymerase E mutants which are effectively the yeast experiment in our tumors and found a 60-40 bias in CA on the leading strand suggesting that the pole E is operating on the leading strand even in humans. This would be the first time that human have replicated this what's known in yeast although it's widely assumed to hold in yeast as well, hold in human as well. So just to remind you of this high mutation rate again and cancer in the mice, these cancers are different from pole E and pole D in the mouse. The pole E mutants lead to primarily intestinal cancers. So that kind of leads to the question well what about pole D in these cancers? Do we ever see pole D mutated? And this on-co-print from the C-bio portal shows that for all these pole E mutants we never see a mutation in the nucleus domain of pole D. So this suggests that that the pole D may be required for some essential function in these tumors and although we don't know what that function is yet this asymmetry is very intriguing. We've also looked at the rate of mutation as a function of the expression levels and you can see that as expression goes up the mutation rate goes down suggesting that transcription coupled repair is operating in these patients. When you look at the hyper mutated this line is flat across the expression levels. And finally we are just getting the first look at progression free survival and Doug Levine showed this slide this morning showing that the patients that are ultra mutated have a better prognosis than patients that are hyper mutated. Similarly in colorectal cancer the microsatellite in stable patients are known to have a better prognosis and so now it's become a very urgent question to find out whether this is a generalizable feature that high mutation rate leads to better prognosis. So in conclusion the rare exonuclease mutation in pole E leads to an ultra mutator phenotype in colorectal and endometrioid tumors. The ultra mutator phenotype defines a new subtype of these tumors that may have unique prognostic features and interesting biological properties and so at this point we're gathering with our colleagues Gordon Mills and Stan Hamilton and MD Anderson cohorts of patients that will be able to test that have outcomes that will be able to verify what the prognosis is. The ultra mutator patients exhibit a signature of transcription coupled repair and the absence of pole D1 mutators suggests that it may perform an essential function in this new subtype of colorectal and endometrioid cancers. Maybe that's transcription coupled repair but it'll be interesting to try to figure that out. The Stan specific mutation pattern associated with putative origins of replication in humans is the first suggestive evidence for confirmation of the yeast model of replication in a higher u-cariat and so we are now sequencing whole genome where we'll be able to look at more origins of replication and get out of the transcribed regions where things could be biased and get a better look at this phenomenon. So with that I'd like to thank all my collaborators especially Nils Winhold and Nikki Schultz at Memorial Sloan Kettering and the rest of the crew at the Baylor Genome Center, the WashU sequencing center who sequenced the endometrial and many of the colon cancers, my colleagues at the Broad as well. Thank you. One question. It was very interesting fact that you didn't see pole delta mutations but you saw pole epsilon mutations and I want to bring up here the analogy with yeast. Many of your samples they actually are defective in mismatch repair either by MLH1 or by combination of MSH2 or MSH3, MSH6 and it is known in yeast that pole delta proofreading deficiency in combination with mismatch repair deficiency just kills the yeast cell because of hyper extreme hyper mutability. However pole epsilon proofreading deficiency is in combination with mismatch repair deficiency is hyper mutable but still can live. So that may be another factor that can be included into all considerations here and we can talk about it later. Okay thank you very much.