The vast majority of people in this country have such high insulin levels, have such insulin resistant levels that are so metabolically inflexible that they absolutely do not do well with intermittent fasting. Shocking but true. You've seen in my last book and heard me talk that 50% of normal weight individuals in the United States are metabolically inflexible. Now, just to review very quickly, normally our mitochondria should be able to take sugar, glucose, and turn it into ATP, our energy currency. They should also, when the need arrives, instantaneously switch from burning sugar as a fuel to burning free fatty acids and ketones as a fuel that come from our fat cells and from our liver. And that switch should happen instantaneously. Very much like a hybrid car can switch from gasoline powering the engine to the battery powering the motors. And that switch can happen instantaneously. But 50% of normal weight individuals can't make that switch.  And I'll talk about why that is in a second. If you look at overweight people and the vast majority of Americans are overweight, 88% of overweight people can't switch between burning sugar and burning fat. And 99.5% of obese individuals, and that's a ton of us in the United States, cannot make that switch. Okay, so why is that so important? Well, when you have high insulin levels, insulin is a fat storage hormone. And insulin's job is to take any extra food that you eat and store it for harder times. That makes sense. But insulin is going up and up and up in our bloodstream as we eat more and more processed foods, we exercise less. So the vast majority of Americans have elevated insulin level.  It's literally blocking the exit. And until insulin levels fall, all that fat that's in all of our fat cells is literally locked in there. And you could stop eating, but you will not release the fat until your insulin levels begin to fall. And here's the bad news.  Number two, ketones are made in the liver from free fatty acids that are released from fat cells.   So what happens? You don't have any sugar in your blood. You don't have any free fatty acids in your blood. You don't have any ketones going to your brain. And what happens? You crash. You get headachey. You get weak. You get angry. You just do not feel well. And that's your body saying, hey, I can't make this switch. So when people start trying to cut out a meal because they heard, oh, you know, I need to have my first meal of the day at noon and you're used to eating a breakfast at 7 o'clock in the morning, that's five hours of going without fuel coupled with what you went through in the night where you don't have any chance to keep your brain happy, much less your body happy. And that's why this is so difficult to do. I can't tell you the number of people, and I've written about this, who fail a ketogenic diet or an intermittent fasting diet because they just have too high an insulin level to access what they really need to do. And 60% of people who try a ketogenic diet, a low-carb, high-fat diet, quit after a month. And it's obvious why they quit because they quite frankly feel miserable. Now, this will happen if you are insulin resistant. I guarantee it. I like to use the example. I could have King James LeBron teach me how to dunk a basketball. And as much as he would show me over and over and over again, I am height-impaired compared to King James. And as much as I would like to replicate exactly what he was doing, I can't do that. So when you see influencers, particularly young influencers, who tell you how easy it is to do an intermittent fasting program, these are people who start with metabolic flexibility. And they're right. It's really easy. Once you have metabolic flexibility, this is easy.  All right, so how do we do it? As I've talked about in my last two books, there's actually a fairly easy way to get metabolic flexibility. And rather jumping in the deep end of the pool and trying to push out your fasting period, what I ask you to do is one hour a week extend when you're going to have breakfast. So if you have breakfast at 7 o'clock in the morning, this week we're going to have it at 8 o'clock in the morning. And then take the weekend off. Relax. The following week we're going to extend another hour. We're going to go to 9 o'clock in the morning. And so on each week rather than going, oh, you're not going to eat until noon and you'll fall on your face, any of us can make it for one hour. And even that one hour change going slowly, week after week, will start to lower our insulin resistance. And I see this all the time. Now, there's places where people kind of run into a brick wall. Let's suppose you made it to 9 o'clock and you're pretty good at that. But then pushing to 10 o'clock, then you go, oh, you know, I'm hungry or I'm feeling weak. That's actually telling you that you still have insulin resistance and this is where you're running into trouble. And as I talk about in the books, we got lots of tricks. One, get yourself a handful of nuts. It won't break your fast. Have a teaspoon or a tablespoon of MCT oil. Have a bar that contains MCT oil. These are really easy tricks. And just hold it at 9 o'clock for another week and then try for 9.30. Lots of different ways. The other thing that I think is important that I've talked about before is when you break your fast, the first meal of the day, make it what's called a mono meal. Make it either mostly carbohydrates or mostly protein or mostly fat. That actually makes it much easier for your mitochondria to power up and make energy. Now, how do you know when you're metabolically flexible? Frankly, the longer you can go without these feelings, the more you're becoming metabolically flexible. So long story short, for most of us, please, please, please do not jump off the deep end and try time-restricted eating those six to eight hours a day. It's going to not work. Instead, try time-restricted eating on a variable schedule of just extending your eating period one hour a week and watch what happens. If you're doing 8.16 fasting, here's how it works. One, you eat all your calories during an eight-hour window, say 10 a.m. to 6 p.m. The rest of the time, you simply don't eat or drink any calories, though water, unsweetened tea, and black coffee are fine. It's that simple and it's amazing for your health. Why? Well, because intermittent fasting is how your ancestors evolved to eat. No, not on a precise clock like this plan, but based on when they found food. It's not like the hunter-gatherers of the past always found two eggs for breakfast after all. No, sometimes they'd have a wild boar to feast on. Other times they'd go days without meals. That's how your body evolved. Now, I would never tell you to go days without eating without supervision. But keeping your body guessing a little is a great way to optimize your health. In fact, a recent study looked at intermittent fasting and people with type 2 diabetes. The results of the study showed about a 15-pound weight loss in about a three-month time period. Why?  Plus, even if your stomach growls a little bit at first, it takes some getting used to after all. Your body knows how to handle a little hunger and you'll be okay. In fact, I tell my patients, embrace the hunger. So, with all the fasting methods out there, why 816? Well, it's not that it's better than any of the other methods. But for a lot of people, it's easier because if you can still eat lunch with your coworkers and dinner with your family, you're less likely to feel deprived. And when you don't feel deprived, you're more likely to stick with the plan. That's why I'm a big fan of 816 fasting for a lot of my patients. It's sustainable no matter what your lifestyle is. And ultimately, your health is my number one concern. So, I suggest picking a couple of weeks that work for you and committing to 816 fasting. Just schedule it so that you can enjoy the meal that's most important to you and your family. That way, you can live your life and enjoy lasting health too. Now, what's the optimal meal to eat if you're only going to have one meal a day? Now, to begin this conversation, I need to set the record straight.  That's the most dramatic finding of the NIH experiments done by Dr. Alfred DeCabo in mice looking at not so much the foods the mice were given to eat, but the timing of when the mice got to eat their food. And what he showed was that it really didn't matter whether the mice were given a high fat diet, a high protein diet, a high carbohydrate diet. The outcome was driven by how short a time period that the mice ate the food that they were given during a 24-hour period. The mice that ate all day didn't live very long. The mice that compressed whatever they were eating, whether it was high protein, high fat, high carbohydrate, compressed that eating window lower and lower, lived the longest regardless of what they were eating and had far less amyloid production and beta amyloid than the animals that ate all day long. So that's actually really exciting news. And as you know, one of my sayings from that book is eat short to live long. So that experiment and the Italian athlete experiment has convinced me that compressing my eating window is one of the strongest ways I can impact my long-term health. So is there any bad news to that study? Well, all the mice eventually died, but the mice in the high sugar group, most of the mice died from liver cancer. And that's actually a very common cancer in mice. So long story short, would I make my one meal a day mostly sugar? No, I wouldn't.  Oh, you know, I can't have this. I can't have that. I can't have that because that's high carbohydrate or that's high fat or that's high protein.  So what would I suggest you have? Well, first of all, I can't say this enough. The more I can eat, have you eat green things, the better off you are. As I mentioned in unlocking the keto code, the more you can eat the rainbow, which really means eat polyphenols, the better you're going to be. I've said this before, multiple times a week I will have pressure cook beans as part of my meal. And that just drives some of my critics crazy, but pressure cooking beans makes them actually an important part of your diet. I learned this from my years at Loma Linda. The other thing I think everyone should add to their diet is nuts, particularly pistachios, particularly walnuts, and we'll go into that on another lecture. But, you know, every day I change what I eat. Do I have my favorite? Sure, but the great thing is I don't think in five years I've gotten through all the yes list of all the yes foods. So there's so much you can do. Can limiting how much meat and dairy you eat help you live longer? Well, according to a growing amount of research, it actually can. In fact, the less animal protein you eat, probably the better off you are. But if you want to live the longest, healthiest life possible and don't like the idea of adopting a completely vegan diet, don't worry. Because today I'm going to share some alternative ways to limit your animal protein intake without having to give it up. On this episode of the Dr. Gunnery podcast, I'll be sharing details about my five-day modified vegan fast in both the plant paradox and the longevity paradox books. I'll also share my tips and instructions for fasting mimicking and intermittent fasting. Both of these things can help you live a longer, healthier life. So stay tuned to hear more. Okay, so let's start first with why limiting animal protein helps your health. Well, I've written about this in the plant paradox and the longevity paradox. And let me start with the Adventus community of Loma Linda, California where I was a professor for a great part of my career. As you know, the Loma Linda's are one of the blue zones of the world and Loma Linda is the only blue zone in North America. And I think that's important to know because the Adventus as a religion in general are promoting vegan or vegetarian belief and eating. And in fact, in our hospital, there was only a vegetarian selection of food. There was no animal products except for cheese and eggs. But what's interesting in the long-term studies of some of the longest living people in the world, the Adventus of Loma Linda, it's actually the vegans that have the longest lifespan and best health span, followed by the lacto-ovo vegetarians, followed by the pescatarians, followed by the chicken eaters, followed by those who cheat and have other forms of animal protein. And this has been now studied for well over 20 years on an ongoing basis. And my colleagues at Loma Linda have published on this and I've documented in my books. And sadly, for every amount of animal protein that's added to the Adventus diet, we see increases in heart disease, decreases in longevity, and increases in cancer. And I've postulated on this in all of my books on why that might be. Now, there's been some excellent studies out of St. Louis University looking at calorie restriction society members, who as you may or may not know in general, reduce their caloric intake by about 20-25% over normal, because of the very strong experimental evidence that calorie restriction extends health span number one. And in all animals studied except for rhesus monkeys, extend lifespan. And as I wrote about in the longevity paradox, there are two competing rhesus monkey studies, both showed improved health span. These animals lived better lives for as long as they lived. One study showed that they lived longer lives than comparable rhesus monkeys. The other did not show a benefit in lifespan. These studies are different, believe it or not, in the amount of protein that was in these two diets. And lo and behold, the protein in the rhesus monkeys that lived longer was less than the protein in the group that did not live as long. And this is actually confirmed in the St. Louis studies of the calorie restriction society. They looked at a hormone that I measure in all my patients called insulin-like growth factor. It's abbreviated IGF-1, if you're looking for it. And you can ask your doctor to measure it. And insulin growth factor is probably our best way of looking at how a receptor called mTOR, and I've talked about this before, is turned on. Now, quite frankly, we have fairly high levels of insulin-like growth factor. We're young because, quite frankly, we're growing. But as we age and kind of cross 40 years of age, we actually see that insulin-like growth factor-1 levels, IGF-1, should start falling. Why? Because if you look at people who have extreme longevity and are doing great in their late 90s, early 100s, they have very low IGF-1s. If you look at, instead, cancer patients who develop cancer, they remarkably have high insulin-like growth factors, unfortunately. And I'll give you an example later on of a recent patient. So at St. Louis University, they took calorie-restricted members, and quite frankly, the Calorie Restriction Society does not bar eating animal products. In fact, they do. So they asked some of the Calorie Restriction Society members to keep calorie-restricted, but change to a vegan diet rather than having animal protein in their diet. And lo and behold, their IGF-1 levels plummeted when they took down animal protein. Now why is that? Well, simplistically, mTOR, the mammalian target of rapamycin, we now know that tor exists in all creatures, including yeast, is an energy sensor. And it senses simplistically amino acids from protein and sugars. And that's what it is interested in. It turns out that there are certain amino acids in animal protein that are far more abundant than there are in corresponding plant proteins. And experiments have shown that if you lessen those specific amino acids in animal protein, then you correspondingly decrease the activation of mTOR. And believe me, we in the longevity community do every trick possible to trick mTOR from being turned on. And if one of the easiest ways to do that is dropping off animal protein, so much the better. Now, so many of you, including me, having been raised in Omaha, Nebraska, think that animal protein eating meat, animal protein of any kind, whether that's chicken or fish or eggs or cheeses, is essential for health. I got news for you. There's absolutely no evidence that any of these are essential to health or to build muscle for that matter. I again like to remind my patients that a gorilla does not eat animal protein and he has more muscle than you will ever have in your life.  In fact, the largest animals on earth are actually plant eaters. So the idea that we can't grow and develop normally just eating plants is one of the great myths. And that myth, of course, has been perpetrated by our industries in agriculture of meat consumption and dairy consumption. And myths are really easy to do as long as you've got advertising dollars. Okay. Now, as you know, I wrote in the plant paradox and the longevity paradox that beef, lamb and pork in their tissue, in their muscles, if you will, have a sugar molecule called Nu5GC that we actually make an antibody to. We have a different sugar molecule that we share with fish and chicken called Nu5AC. And while that distinction is only one molecule difference, when we see Nu5GC and we make an antibody to it, by mistake we often attack this sugar molecule on our blood vessels. And there's several papers that suggest that one of the reasons meat eating is associated with more coronary artery disease is an autoimmune attack on our blood vessels. And I think we should be aware of that. The other thing is that cancer cells use Nu5GC to shield themselves from detection by our immune system. And so that may account for the very strong epidemiology linked correspondence between, for instance, colon cancer development or even breast cancer development and meat eating. Now, those associations are actually fairly strong, but it could just be that the sugar molecule and beef, lamb and pork may be part of the consequence, not just the fact that you're eating animal muscle. Now, I understand that going vegan or nearly vegan isn't something everybody wants to do. In fact, I don't do that.  And I supplement my diet usually on the weekends with shellfish and occasional wild fish. But that doesn't mean that I don't eat meat. In fact, believe it or not, probably every three months I will have a grass-fed, grass-finished piece of steak. And you can visit me at Lucky's and Montecito where I eat that grass-fed, grass-finished steak every now and then. Do I do it every day? No. Do I do it once a week? No. It is a rare occasion. Hey, I'm from Omaha. Okay, I got to do it occasionally. If you're in the group that says, you know, there's no way I'm going to go vegan. There's no way I'm even going to go vegetarian. I like my meat. I like my chicken. I like my fish. That's okay. Here's the exciting part. So I've become, I think, good friends with Dr. Walter Longo, who's the head of longevity research at USC Medical Center. And I think Dr. Longo is rightfully one of the greatest researchers in longevity and how to achieve the benefits of calorie restriction or the benefits of fasting without actually doing either one. I want to just talk about fasting for a moment. I know I've talked about this before. But fasting has certainly come a vogue again. And for the average American listening to this, fasting a water fast, a prolonged water fast, unless you're properly prepared and taking protection with certain supplements like activated charcoal, like chlorella, like liver enzyme detoxification supplements, then you probably don't want to do a prolonged water fast. Because unfortunately, heavy metals and pollutants are stored in our fat.  Well, duh. But as you use up that fat, outcome those heavy metals and pollutants. Now the problem is the liver does a horrible job of detoxifying these guys and even getting rid of them. And I've talked about this before.  And I see so many people who have been doing fast and they have incredibly high levels of mercury and lead and cadmium in their blood while they're doing this without realizing they've actually released this from their fat cells. That tuna, that swordfish that has toxic levels of mercury in their flesh are big strong animals because the pollutants are in the fat where they can't do any harm. So in our modern society, fasting, prolonged water fasting, should be done with caution, should be done under medical supervision, and you've got to use the right supplements to help you with that fast. Okay, so what can you do instead? Well, thanks to Dr. Longo's work, which I cite in all of my books, what he did was say, well, wait a minute. We know that eliminating animal protein for a period of time changes how mTOR is turned on. And he actually designed experiments first in mice and now replicated in humans that show that a five-day period, consecutively of a modified vegan fast where you're only eating about 600 to 800 calories of basically vegetables. You can certainly have fats from plants, but you eliminate all animal protein. You eliminate dairy. You eliminate eggs. And so you have dramatically dropped the amount of animal-based amino acids in your diet. And what he found was all you need is five days in a row of doing this consecutively and you will act in terms of activating stem cells, activating your immune system, activating anti-cancer genes as if you had been on a fast, a calorie-restricting diet for the entire month. All right, how about a prolonged water fast? Now, of course, this is the most well-known, historically speaking, approach to fasting. Even Jesus is said to have done it for 40 days and 40 nights and almost all great religions have some form of prolonged water fasting. There's clearly benefits in ancient times to water fasting, but not so fast, excuse the pun. Most of us store our heavy metals and organo-pesticides in our fat cells. So when we stop eating anything for a continued period of time, we release not only fat from our fat cells, but those heavy metals and organo-pesticides. We have a horrible detoxification system in our liver to eliminate these problems. In fact, Ray Wolfer, the famous UCLA professor who was the doctor on the Biosphere 2 experiments in the Arizona desert, documented in that group of people who literally starved for six months. Their levels of heavy metals and organo-pesticides went up dramatically and remained dramatically high for a year following re-eating. That's because they put them into their bloodstream and they couldn't get rid of them. So, right now for Americans, water fasting is dangerous because of that fact. Now, if you want to do that, understanding the risks, you want to absorb those heavy metals and organo-pesticides by taking chlorella tablets and activated charcoal. That will bind those heavy metals and prevent them from being reabsorbed into your system. But you don't need a prolonged water fast. Instead, time-controlled intermittent fasting will have just as good an effect. Or, as my friend and colleague Dr. Walter Longo has shown, a fasting-mimicking diet, which uses a five-day low-calorie vegan fast once a month, has been shown to duplicate the ability of a water fast in terms of health benefits without the danger of the heavy metal and organo-pesticide release. If you found this video helpful, I think you're going to love this one. One of the guys who really turned me around on the power of lectins and how we reacted them was a guy who I talk about, Tony, in the plant paradox. Tony is a friend of mine, he still is. He came to me early when I actually wrote Dr. Gundry's Diet Evolution. He was one of the original...


Everybody forced here ripping 2022 impeccable football hobby Three box full case number 20 random team style results can be found at any time late in sports cards calm Let's get started everybody. Good luck. All right, there's a Justin Jeperson 41 of 50 Vikings Steelers TJ Watt 62 of 75 and a Tyree kill 36 of 50 dolphins Oh What's up Greg dude, I was I couldn't believe I couldn't believe I called it. I was that was wild Jelani Woods rookie auto 45 and 99 for the Colts. Congrats, man. That was a great break for you 49ers George Kittle canvas creations auto 17 of 25 Nice kiddle huge for them. No, there's no platinum in the product elegance patch auto Randall Cobb 28 of 75 packers I can call platinum all day You ain't gonna get it. You don't get it What are the lottery numbers dude if I if I knew I wouldn't tell nobody I don't Would show up just wearing like giant chain one day Giant like raided rookie like solid gold Stunted out he has a trash Steve young auto Niners to a five Super Bowl champion Niners cleaning up right now Jake F No purdy no problem right now Get that magged and Falcons elegance helmets and glove rookie auto Drake London 19 of 25 That's crazy to That's true. If I call it. I might happen Get that mag. There you go Falcons really nice start to this break Sam's ruined Drake London for you. Yeah Every time force says I twitch it's yeah, every time Sam pulls when he says it I'm sorry guys Do the same as an agent of chaos you have to respect it otherwise he'll he'll JC horn 4 of 10 Panthers And can makers 1 of 50 rams. What are you guys saying? Who's your top receiver from this class? Top receiver from the class Elegance patch auto Michel Hartman jr. Chiefs 3 of 15 Nice three-color player worn patch No, I definitely show up to break the next day.  Yeah, I'd have like a Bright orange tuxedo on with a top hat I'm gonna say the best receiver from the class Let's see run it. I'm running all through my head right now. I'm gonna go. We'll go off the board I'm gonna say it's gonna be Traylon Burks Or at least I hope they go fucks there West welker masterstrokes auto Patriots James Williams is another guy that hasn't played yet that we could see I'm gonna go Burks. I'm gonna say Burks Full hot take ish, but we'll see we'll see Nice West welker there for the Pats rookie landscape auto sauce gardener to 99 jets. So Kenzie Pickens could be it. It could be Olave pickings Wilson It could be Dotson. There's some good ones. Y'all Christian. It could be Christian Watson as well Dotson Watson It could be Drake London. You got RPA Falcons Desmond Ritter 78 of 99 there we go Falcons nice RPA and a Bears rookie patch and helmet auto Belich Jones jr. 11 at 35 Yeah, you could legit say like probably eight answers and it's like, okay. Yeah, I can see that. I could see that guy be the best What do we have Watson Wilson? Olave James and Williams Dotson Burks pickings. I miss anybody Last year it's about it, right Romeo Dobb. Yeah, Rob Dobb is good too. Can't sleep on him It's a long ways to go for a lot of these guys Who's gonna get the most consistent quarterback play who themselves is gonna take it a leap forward in their game Yeah, Burks was decent in the time he played match. He hasn't even touched the field yet Got Mike Evans to 75 buck in the years and to 25 Terry McLauren commanders. Yeah, I was pretty awesome That was pretty awesome. Kenzie Another bad moon rising auto for the Falcons 89 of 99 I pulled like half of these I think Bad moon rising Another gold bar would be back to that case gold bar. Oh my god. I can't even imagine Willie Rove illustrious ink 29 of 75 chiefs Niners celebration auto Jerry rice Jerry Jerry You think we could go on the Jerry Springer show We'd have to make something up you and Sam could go. Oh, yeah, you and Sam go on the Jerry Springer show They film it here in Orlando. No One of one of them they film in Orlando like Wilco's or something That'd be fun Nice Jerry A Drake London rookie auto 44 of 99 for the Falcons. Oh London. I forgot to say London There you go Falcons nice hit there Elegance rookie patching helmet auto Carson strong four of 75 Eagles And the bar card Troy out to find silver with the shield on it. Traylon Burke's titans the rookie 15 to 25 Tennessee very nice hit there Well, you see my face and the reflection of the silver ever need any hairs in my nose Yeah The old whistler the oh, yeah old whistler that's the worst. Yes trying to fall asleep in your own breathing is keeping you awake All right recap here for case 20 Carson strong Drake London Jerry rice Willie Rowe bad moon rising Milish Jones jr. Desmond Ritter sauce Gardner west welker Kate otten michael hardman jr. Randall cob george kiddle in jelani woods Silver bar rookie trail on berks titans the 25 helmet and glove relic rookie auto Drake London falcons to 25 And nine is a super bowl champion auto steve young two out of five more impeccable coming up


The results of this study suggest that ergonomic factors such as workplace design and equipment are important determinants of job satisfaction among sonographers in Riyadh, Saudi Arabia. Additionally, it was found that good health and regular physical activity are associated with higher levels of job satisfaction. Furthermore, gender differences were observed in terms of ergonomics and job satisfaction, except for lifestyle variables. This article was authored by Azma Zadeh, Lina Fami Hamad, Sulwasat Awad, and others.


What is up, everybody? Welcome back to the channel. This is the third and final video of this series This right here is the most important man. If you plan on capturing leads online or making cells online through Facebook advertising This is the most important Setting up your custom conversions. Okay. I always kind of give an example of let's say let's say my web Like let's just go to any any one of my websites You have your landing page, right? You have your landing page and then when someone clicks on this button Right, if they click on this button, then it brings them to an opt-in form, right? And then they opt in This second page is what Facebook wants to know They don't want to know your goal. Your goal is to drive them to your landing page to capture lead But what is your ultimate goal? Your ultimate goal is to get them here to the thank you page This page this URL is what Facebook wants to know. That's what you set your custom conversion around, okay? And this is super super important So in my case with my new funnel that I just set up It's these pages right here that I want to create custom audiences or custom conversions around, okay? It's it first starts with the web class So the web class so once they opt in they come to my landing page They enter their name and email and all of a sudden they're watching a webinar, okay? I want to create a custom conversion around this because again, this is a page After the fact this is a page that they got to and they only got to it By entering their name and email. Okay, they opted in so Facebook wants to know What is the page that you're taking them to it's this page right here now? When they come down and they click on the orange button and they add to cart Facebook also wants to know that page as well. Okay, because when I set up this custom conversion Not only am I gonna is Facebook gonna start showing me showing my ads to people That are most likely to convert But it's gonna also make sure that my ads are going to the most relevant people and my ad cost is not through the roof Okay, because I'm letting Facebook know I'm saying hey man These are the pages within my website that are the most important. Okay, I'm looking to get people here Okay, so I'm looking for people to opt in and get to the webinar I'm looking for people to click the orange button and get to the checkout and for sure I'm looking for people who can complete the order Facebook's machine is gonna start showing my ad to people who are likely to get to this page, right? So That's all because I'm setting up custom conversions. So here's how we're gonna do it We're gonna come into our ads manager. We're gonna hit the three lines We're gonna come down hit all tools and go to custom Conversions right here. Okay, once you click on that one It's gonna bring you right over here Make sure you click on custom conversions and then we're gonna click this blue button over here Okay, so now I'm gonna be able to name it I'm gonna I'm gonna let Facebook know what the URL is and so this one here is going to be Web class. Okay, let's name this one web class web class registrants Web class registrants. Okay, this right here Registrants, okay, perfect, and then that's the actual pixel and then the conversion event This is going to be We're gonna go lead. Okay. That's the actual event So we'll go lead and then the URL Contains doesn't contain or equals and I can go what I'm gonna do is I'm gonna come over here And I'm gonna just simply I'm not gonna grab the HTTPS or the WWW I'm only gonna grab the URL that that from my domain and on okay, and then I'm gonna bring it over here and I can go it contains paste that in and create Okay, so That's that and then what I want to do is I want to also Create another one for the add to cart. So I'm gonna come over here and I'm gonna grab this Copy that and I'm gonna click on the blue button again, and we're gonna go we're gonna we're gonna name this one TSRE ATC add to cart. Okay, and then that one this one's gonna be initiate checkout just like that and then contains That URL, okay, and then I'm gonna hit create and there goes that And while I'm at it, let me edit this really quick So web class, I'm gonna just simply Edit this Okay, so we'll save that. Okay, perfect. Okay, and then what I'm gonna do. So I got the web class Registrants, okay, I got the add to cart and then I want to go order complete These are people who have purchased. Okay, and I got to edit this page still, but there's there's the template There's the URL. So I'm gonna come over here hit the blue button and This one's going to be TTSRE Course Okay, and then I'm gonna go this one's going to be purchase Contains and create Okay, now what I'm also going to do is let's go back to let's see if I can add it here Web class registrants. Let's click on this and let's see if I can actually Okay, I wanted to add you I thought I can add in Let me see if I can do it this other way Okay, so if anything red web class registrants, let me just I'm gonna copy that and I'm gonna delete this and I'm gonna do it again Because I wanted to see if I can add a second one. So let's come over here T S R E a web class Registrants Okay, so this is gonna also be this is gonna be lead again as we did and then contains Let's go to I Want this one I might have to do this individually or actually perfect actually I can go Yeah, I think it contains I could put yeah perfect I could put this other one, okay So we're gonna go web class in progress Okay, there we go. So I want that and there it goes there. Okay, perfect.  So contains that hit done and those are the most important you guys those are the most important People who actually Registered and again, it could be for a webinar. It could be to download your book It could be to Schedule a call it could be anything when a person goes to your landing page and they enter their name and email What is that next page? That's the thank you page, right? What I'm telling you is create a custom audience or custom conversion Around that thank you page which in my class.  And so that right there you guys most most important if you're planning on capturing leads or making cells online Set up your Facebook custom conversions first and then now here's what we do with these Now as we come over here to the ads manager and We go and run our next ad Let me refresh this real quick Let me refresh this Okay, perfect. So now as we come over here to the ads manager and we click on the green button, okay? 99% of the time if you guys are looking to capture leads or make cells online 90% of 99% of your ads are going to be conversions. That's why we set those up Okay, we set those up to optimize for conversions. There's only one thing. I'm looking for Facebook and that's to capture a lead or There's only one thing I'm looking for Facebook and that's to make a cell, okay? And so that's conversions. That's conversions a lot of people mess around they go engagement They go video views or maybe even lead generation. Some of you guys are successful at lead generation with this Objective brand awareness reach traffic now to start you may have to go traffic to get that pixel You know some data, but after that you're gonna go conversions That's that's the 1% the 1% you're running traffic ads to the landing page Okay, that's the 1% of the time and then after you start to get data to that pixel Then you're running conversions 99% of the time from that point on you're running conversion ads Let's hit the continue and then now over here. This is where I'm gonna be able to let Facebook know This is the type of person. I'm looking for okay a person who landed over here or a person who? Landed over here. I'm very I'm being very specific with Facebook I'm telling them exactly the type of people I'm looking for okay So that is what brings us to the second step Which is the ad set and you'll see this red and all we're gonna do is we're gonna click and we're gonna look for that Conversion that we just set up. So if I scroll through right here, look at this There's the one TSC web class registrants TSC core students or I can go lead or I can go initiate checkout What I also want to do is I want to go to that four days left and let me refresh this actually it should be up now But this one should have been over here as well. Actually that one that one's in the lead one also so that right there you guys it'll be it'll be TSC TSE core students or the web class registrants and What we're missing is we're missing Actually, it's the lead the lead I think that's the one that we set up under There's the add to cart. Actually, there's the TSC add to cart. Okay, so there's the TSC add to cart Let's go to let's refresh So all I got to do is I got to just refresh this pay or bring it back up And then it would have been it would have been available. It would have been rather than being green It would have been or rather than being red. It would have been green I don't think it updates it right then in there, but let's see. So there's the actually there's the there's the TSRE ATC that's the add to cart, but it's red. Let me come back to campaign Conversions and let's come back and let's see if it's actually green. You want to always refresh the page So let's see if it's if it's green if it's showing up yet. So we come over here and We go Okay, so I guess it still needs it still needs a little bit of time. That's fine. That's fine But it's right there. It's right there. So as as I'm saying as we start to bring traffic and data to the pixel Then those will start adding up, you know, and then and then what I'm going to do is I'm going to go I'm going to go Facebook. I'm looking for people Who who are likely To land on The order complete page. I am optimized and I'm telling facebook I'm running conversion ads to get people to that page finding more people Like that that are likely to get to that page and that's conversions.  All right, guys So i'll see you in the next video over now


Mr. President, thank you for coming over to speak to us this morning. We're pleased to see the high priority your administration has. Thank you very much. Thank you. You've done that already. George Brooks, Anne Griffiths, members of the board and the family members and members of Congress. I think most of you know that during the course of any given day we meet with an assortment of groups who represent a cross-section of interests and causes. None of those meetings are routine. But I must tell you that this meeting today is more than special. The anguish you've suffered, the families of brave men, of listed prisoners of war or missing in action, the misery and anguish is unspeakable. Something the rest of us can really never know, even in a partial measure. Twelve years ago I said something to a group of you in California that I believe is even more true today.  And what a burden you've had to bear. You watched as we disengaged from Vietnam and many of our prisoners of war returned for an emotional homecoming. You've seen task forces and committees hold hearings and issue reports that attempted to foreclose hope. But as the tragic flow of refugees from Indochina began a few years ago, those columns of humanity who had suffered hunger and thirst and disease and piracy brought with them first-hand live sighting reports of American prisoners held captive after 1973. As this information was investigated, respected figures in the intelligent community reached personal conclusions that these reports were credible, even though the circumstances of the sightings prevented confirmation. But with these refugees and the news they brought another tragedy is unfolding. It's unfolding here at home. You, the families of our missing men were trying to be heard. And yet you were sometimes unfairly and cruelly branded as emotionally distraught groups that ignored reality and simply hoped against hope. The government and public attention began to wane. And instead of being a full partner with your government in attempts to learn the fates of loved ones, you were confronted with legal rulings that presumed the loved ones were dead. You found yourselves quite literally on the outside, driven in some cases to demonstrate for attention in front of the White House gates.  Your government is attentive and intelligent assets of the United States are fully focused on this issue. Furthermore, I pledge to you we will take decisive action on any live sighting report that can be confirmed. We're also working to achieve the accounting of our missing men. I'm sure you understand that some of these approaches must be done quietly. As Judge Clark told you yesterday, despite the differences between our governments, we are – have followed up encouraging Lao response to a recent visit by the league's delegation. We're fully prepared to take additional concrete steps with the Lao government to improve relations. I pledge to you that the progress on the POW-MIA issue will be the principal measure of their sincerity. I wish to recognize publicly their positive steps to date and call upon them to continue with us in this humanitarian effort to end the years of uncertainty that you have endured. I also called on the government Hanoi to honor their pledges to the American people on the POW-MIA issue. Not for me, not for our government, but for our missing men and those of you who did nothing to deserve the terrible emotional ordeal that you've endured. Now these steps are an indication of how things are changing for the better and how the work of this – those of you in the National League of Families – has helped bring about this change. You are the ones who have forged a partnership to realize our common quest, the return of all POWs, the fullest possible accounting for the still missing, and the repatriation of the remains of those who died serving our nation. The myth that this effort is partisan or needlessly raises your hopes has now been dashed. The government bureaucracy now understands that these goals are the highest national priority and there is strong bipartisan support in the Congress. Those Americans who attempted to discharge government responsibilities through private efforts should now understand that the full resources of our government are now committed to these goals. Today is a time for remembering many – the private donors, the congressmen, the government employees, all those who are dedicated to organizing and supporting a variety of projects to achieve our goals. Because of the very nature of the work, they must shun publicity, but I want them to know that their quiet and responsible efforts represent the highest patriotic humanitarian values. I urge them to continue on with their work regardless of the obstacles and frustrations, for the return home of only one of our men will be a personal reward of far greater value than any words spoken here today. But beyond all this, I've mentioned that there are, of course, those of you here today. Today, this is a room of heroes who kept a vigil of unprecedented faith and devotion. Through all the years of heartbreak and mistrust, you have been the ones who cared. You are the ones who asked for justice, for deeds, not words. The membership of the National League, families, past and present board members and your National Office staff deserve the gratitude and accolades of this nation. And I think I should mention other individuals who share our goals such as Fred Travolina, a returned POW, Captain Jerry Coffey who's also given without regard to personal gain. So all of us can be gratified that progress is being made, but never satisfied. We need greater public awareness from the American people. So I ask each American who hears or reads of this to find a way to help. No matter how small each individual effort may seem, it is needed. I ask too that you continue to provide us with positive suggestions through your Washington office. We welcome and solicit your help and cooperation as well as the criticism when you feel we deserve it. It's possible there will be differences from time to time on tactics and strategy, but I repeat. We are heartfelt allies and friends. Our goals are the same. The government is large. It's possible sometimes you'll hear voices that will sound contradictory or insensitive, but we're doing what we can to eliminate that. So please don't let it shake our larger faith. Only if we're united. Only if we have faith in each other. Can we finally hope to end the tragic ordeal that you've endured with such steadfast and wondrous courage? I know I've spoken before and told of when the POWs did return immediately after the agreement. Nancy and I were fortunate enough. I was governor then in Sacramento to have several hundred of them, not all at once of course, couldn't get the men but in groups in our home. One who was here at this table this morning was one of those. We heard such stories. We saw them such courage. One night I, after what I said to Nancy, where did we find such men? And the answer came almost as quickly as I'd asked it. Found them where we've always found them. On the farms, in the shops, in the offices, on the streets of towns and cities and American farms. They're just the product of the greatest, freest system men has ever known. Speaking for Nancy and myself, you and they will be in our prayers. God bless you all. Mr. President, on behalf of the families of the missing men, I want to thank you for your strong commitment and let you know we are looking to you for resolution of this issue. I'd like to take this opportunity to have presented to you a plaque of the National League of Families emblem which was hand-carved by our Vice Chairman, Commander Ralph Gaither of the United States Navy. I might add that Commander Gaither survived over seven years of imprisonment as a prisoner of war in North Vietnam. Commander Gaither. Mr. President, with respect for your personal dedication for the return of our missing men, we, the members of the National League of Families of Prisoners Missing in Southeast Asia, present to you this plaque with all of our love, our hope, and our prayers. Thank you very much. I shall treasure this. Thank you. Thank you very much.


Today, I have the pleasure of speaking with Chris Dobbin from Nova Leap Health. How are you today, Chris? Good. Thanks for having me, Tracy. Well, Chris, I got to tell you, here's what I love. You just put out your third quarter results, and this line says, Nova Leap's financial results are the best in the company's history. How about we start there? Sure. Yeah. Okay. Anytime we can put out results like that, I think it speaks well for the company. We've been fairly consistent in terms of how we buy our businesses, in terms of how we run our businesses, we run a decentralized organization, but it's good to see that the efforts that our staff are putting in are really paying off from a financial perspective. Okay, but let's be more, I actually had Raj put some numbers together for me. All right, you're up 23.44% since the new year, 38.6% in the last six months, and up 58% in the last three months. Those are some numbers. Speaking of numbers, you've gone eight quarters in a row of exceeding revenue expectations. Is that correct, or is it nine now? We've had nine quarters of increasing revenue growth, yes. Okay, so let's tell us, looking at your stock volume, as well as it's doing, though, let's be honest, we think it should be doing better, is that correct? Look, anytime I think you have a performing company, you have a management team that's delivered on what they said they would do, then I think that speaks positive for what the stock should be doing. So the market will take care of itself, but it's nice to see the market at least recognize what we've been doing, and at least doing what we've said we would do. So from that perspective, it's pretty positive. And of course, Chris, we know that one of those CEOs are very focused on the company schools and mandates, but I think I'd love it if you could just share with our audience what you think is making your company different from the many other small caps out there that are really, really struggling. Why are you actually performing when it comes to revenue? What are you doing right? Well, I think there's a couple of things. One is we really have a clear vision of where we want to go, and that vision has never changed from day one. And we've always told the market, look, we're an acquisitive type of company. We think we can buy these businesses that are really good, you know, acquisition multiple. It works well for us. It works well for the seller. And we think after we've taken ownership of these businesses, you know, we have a sense of what needs to happen within these businesses from the day we take them over in order to improve them. And that starts with improving the service to our clients, investing in our caregivers, watching our costs, treating our care professionals well. So a number of things that go into it. But, you know, we're buying these small businesses. It's the market that we're in. We're not off trying to find a huge acquisition because that, from a risk perspective right now, is just not appropriate for us. And I just think we're good at executing and hiring great people primarily internally. I mean, we've done a really good job of, you know, promoting people within the organization. And that's really bowed well for us thus far. We have a client that's now getting close to a $2 billion market cap. And one of her tips was that she would meet every week with her team and go through every single dollar that was spent. So I'm going to draw our audience's attention to your background and how meticulous you are with every single dollar spent. Can you talk to us a little bit more about that? Yeah, look, I'm not going to say we're crazy, but we do pay a lot of attention to our numbers. And really, we do that on a weekly basis, on a monthly basis. Obviously, the quarterly results speak for themselves. But, you know, we do pay attention to details. We pay attention to our revenue, how we bill. We pay attention to our caregiver rates and ensuring that they're at market or above market. We pay attention to overtime. We pay attention to the cost that go into running an office. You know, we know what every agency that we own should look like. And it's just a matter of making sure that we're getting to where we should be. So, you know, from a financial perspective, I think those are easy things to do, right? The numbers are the numbers. And as long as we monitor those on a regular basis and people are aware, you know, what we're striving towards, I think, again, I think they'll take care of themselves. And of course, as some of you out there may not be familiar with the actual business model and formula that NOVA Leap Health is currently utilizing, can you just talk to us a little bit about that and then let's talk about your most recent acquisition, please. Sure, yeah. So when it comes to our model, essentially, we're out there and we're looking for small businesses, so small home care businesses, primarily in the US. They generally run between a million to three million dollars of revenue. They're in a secondary market, so where it's less competitive. We've been buying in New England and most recently in South Central. But these are businesses that have been around for 10 or 15 years. They've been predominantly owned by a founder who's looking for a succession plan. And so we identify these businesses as part of our roll-up strategy. So we see ourselves as a consolidator. And then we look to make incremental improvements, whether it be revenue or expense management or training or marketing. You know, every agency is a little bit different and unique, but we bring those incremental improvements to bear. And then as we add these small businesses to a larger platform, we start to see the pay-offs from a financial perspective. So what should we as shareholders anticipate in this upcoming quarter? Well, look, we said that we do up to four acquisitions this year. We've hit three. We still have a fairly robust pipeline and we do see opportunities on a regular basis. We'll act on the ones that we think are worthwhile acting on. You know, we're not done expanding within New England. We just made an acquisition recently in Massachusetts. It's a very nice tuck-in for us. We've recently expanded to South Central. So we did an acquisition in Oklahoma. We see that as an area where there's quite a bit of expansion opportunity for us. So we'll, you know, we'll continue to pursue acquisitions if they make sense for us, but certainly we're not done growing. Well, Chris, as always, it's a pleasure. Thank you for joining us today and congratulations. Thanks, Tracy. Appreciate having me. Take care.


Good evening aspirants welcome to the hindu news analysis by Shankar A. Sakrami for the date 31st of July 2023 displayed here are the list of news articles we will be going through today. Today I have covered articles from both today's newspaper and yesterday's newspaper. Now without wasting time let's start today's discussion. Look at this news article this news article talks about the Sinuvantograph Amanman Bill 2023 the bill brought about certain changes for example the bill has introduced new graded age rating for movies this rating system will help parents decide whether to let their children watch a film unaccompanied or not like this the bill made many changes but what has not changed is that the CBFC that is the central board of film certification which should have been a mere classification or certification body will continue to remain a censoring body that is rather than issuing certificate to the movie the CBFC will continue to cut and chop the movies in the name of censor this is about the news article given here in this context let us go through some of the important provisions of the bill firstly know that the bill seeks to amend the cinematograph act of 1952 the CBFC is constituted under this act only this board certifies films for exhibition such certification may be subject to modification or deletion the CBFC may also refuse the exhibition of any film the bill did not introduce any changes in the powers regarding the CBFC which is the main point of contention in the amendment this is what I mentioned earlier let me explain you with a simple example say a movie contains nudity and bad words the CBFC will issue a certificate and in addition to this the CBFC will also censor the swear words are the bad words under nudity portions that is it will continue to act as a censoring body in addition to acting as a certification body this is the first important provision of the amendment bill secondly the bill substitutes UA certificate into three other certificates to indicate age appropriateness the categories include UA 7 plus UA 13 plus and UA 16 plus this means that children younger than the given age limit can access such movies with parental guidance alone this is in line with sham benagal committee 2017 recommendations moving on thirdly a separate certificate for television or other media has been introduced mainly films with a certificate or a certificate will require separate certificate for exhibition on television or any other media that is prescribed by the central government the CBFC may also direct the applicant to carry out necessary modification or deletion for the separate certificate so that it can be telecasted in the television this is the third important provision lastly and most importantly the bill prohibits carrying out the unauthorized recording and unauthorized exhibition of films in order to stop piracy according to the bill attempting an unauthorized recording will also be an offense here an unauthorized recording means infringing copy of a film at a licensed place of film exhibition without the owner's authorization in simple words recording film during film exhibition in theaters and transmitting or distributing them for profit or any other unauthorized purpose has been made a punishable offense under the bill that is sharing or selling videos recorded from movie theaters has been made a punishable offense this is done mainly to curb piracy see this has been mainly introduced because the film industry is facing a loss of rupees 20,000 crore annually because of piracy this is why such arrangements has been made the above funds will be punished with imprisonment between three months and three years and a fine between three lakhs or five percent of the total production cost of the film this is the punishment provision provided in the new amendment bill these are some important provisions of the amendment bill with this let us conclude this discussion and take up the next news article now take a look at this news article recently the Supreme Court directed two activists namely Vernon Gonzalez and Arun Ferreira to pair their mobile phones with the national investigation agency probe offices now why did the Supreme Court do this earlier these two activists were arrested by the NIA in the Bhima Corregan case subsequently the activists sought bail before the Supreme Court while granting bail to them the Supreme Court imposed certain conditions the court said the activists have to enable their location status in their mobile phones for 24 hours a day apart from this their phone should also be paired with an investigation officer of the NIA this enables the investigation officer to identify the exact location of the activist so some people say that the direction of the Supreme Court is violating the fundamental right to personal liberty life and privacy this is all about the news since the news article here talks about bail now is the right time for us to revise about bail and the types of bail let us start the discussion first by understanding what is bail bail is taken from the French word bailer bailer means to deliver or to handover basically the term bail refers to the temporary release of an accused person from legal custody in other words bail denotes the provisional release of an accused whose trial is pending and the court is yet to announce the judgment see in judicial terms the term bail means the security amount that is deposited in order to secure the release of an accused note that the bail is regulated by the code of criminal procedure that is CRPC under the CRPC bail can be granted to the accused person either by a police officer or a judicial magistrate the main motive behind the bail is to secure presence of an accused person at trial and to protect the liberty of the accused person while they are awaiting trial okay now with this information let us look up the types of the bail generally there are four types of bail in India they include regular bail interim bail anticipatory bail and statutory bail now we will look at these types one by one first let us take regular bail regular bail is issued to an individual who has been arrested and detained by the police to put it in simple words regular bail refers to the temporary release of an accused person from the police jail to ensure his attendance at the train now let us take interim bail see the interim bail is issued for a short period it is granted to an accused before the hearing of a regular or anticipatory bail then comes anticipatory bail see a person can seek anticipatory bail if such person suspects that he may be arrested for a non-bailable offense this means that a person can seek anticipatory bail before he gets arrested by the police so if an individual has been granted anticipatory bail by the court he cannot be arrested by the police finally let us see few points about the statutory bail note that the statutory bail is also known as default bail the statutory bail is given when the police or the investigation agency fails to file a report within a certain time frame see these are the four types of bail and that is all regarding this discussion in this discussion we saw what is bail and the types of bail now let us conclude this and take up the next news article take a look at this FAQ article this article is speaking about different aspects of human challenge studies here the term human challenge studies refers to the studies in which human beings are deliberately exposed to studies this practice will help the researchers to learn more about the diseases now why is this topic human challenge studies suddenly in use see recently that is on 17th july the indian council of medical research posted the consensus policy statement for human challenge studies in india the statement has been posted on the icmr website for the public consultation for a period of about one month because of this only the topic human challenge studies appeared in the news today see this article speaks about the importance of human challenge studies then about the difference between traditional clinical trials and the human challenge studies and finally about the challenges surrounding human challenge studies in india so in our discussion we will understand all these points in detail okay before getting into the discussion the syllabus regarding this discussion is highlighted here you can go through it now let us start with human challenge studies as we saw earlier the human challenge studies refers to the studies in which human beings are deliberately exposed to a particular disease and this practice will help the researchers to learn more about the disease for example let us consider person a and he is deliberately exposed to covid virus as person a is exposed to covid virus he gets various symptoms and health complications this will help the researchers to understand the progress and the severity of the disease like covid so we can say that in the human challenge studies it will help to better understand any particular disease okay note that india has not undertaken human challenge studies before see in india the disease burden from infectious disease is significantly high and the mortality rate from such infectious disease stood at 30 percent in india apart from this india is also continuously encountering various infectious disease year by year because of this reason the importance of human challenge studies was felt by the indian government so recently the icmr posted a consensus policy statement for human challenge studies in india so we have to wait for future updates regarding the policy for human challenge studies in india now moving forward let us understand the importance of human challenge studies firstly human challenge studies help us to understand various aspects of infectious microbes and their disease caused by such microbes secondly human challenge studies will speed up the process of finding a safe and effective drug or vaccine for various infectious diseases thirdly the study will provide better information about multiple aspects of disease like pathogens infection transmission and prevention and finally human challenge studies will supplement the traditional clinical trials as we saw earlier india has not undertaken human challenge studies before as of now india is relying on traditional clinical trials to understand about a particular disease so if india undertakes human challenge studies it will supplement the traditional clinical trials and it will also help us to find a more effective medical interventions this is all about the importance of the human challenge studies now moving on let us see the difference between the traditional clinical trials and human challenge studies the first major difference lies in the nature of exposure to pathogens see the participants in traditional clinical trials are strongly advised to adopt and adhere to safety measures this is to avoid getting infected with the disease but if you take the human challenge studies the participants are deliberately exposed to disease causing pathogens this is the first difference now coming to the second difference the second difference lies in the purpose see the traditional clinical trials are undertaken to study the safety and the efficacy of the drugs and vaccines but human challenge studies are carried out to understand various aspects of the infectious studies it also help us to understand and develop drugs and vaccines for the studies this is the second difference now coming to the final difference as we saw earlier in the human challenge studies the participants are deliberately exposed to disease causing pathogens so generally there is no safety in conducting human challenge studies because of this fact the human challenge studies are often undertaken to study less deadly diseases like influenza, dengue, typhoid, cholera and malaria but if we take traditional clinical trials the participants are strongly advised to take safety measures so the traditional clinical trials will help us understand about the deadly diseases like SARS COVID okay this is all about the difference between the two studies now finally let us see the challenges surrounding human challenge studies in India as we saw just now the participants in the human challenge trial are deliberately exposed to disease causing pathogens this fact makes the study more challenging now coming to ICMR's consensus policy statement see the ICMR consensus statement has clearly mentioned that only healthy individuals in the 18 to 45 year age bracket are to be enrolled for human challenge studies the statement also clearly mentioned that children and women who are pregnant or lactating will not be enrolled for human challenge studies in addition to this the statement also mentions that the participants with pre-existing medical conditions are to be excluded from the human challenge studies here comes the problem see most of the people are unaware of such medical conditions so if they are enrolled for human challenge studies the impacts will be severe so it is essential to carry out detailed medical examination of the participants before enrollment now coming back to the consensus statement of the ICMR see the participants of the human challenge studies have to be paid with some money right see the consensus statement stated that information on payment for participants should be mentioned in the consent form but there is one condition see the statement mentioned that the exact amount of payment for participation is to be revealed only after the volunteer has consented to the participation this also creates a problem see the participants are risking their lives for human challenge studies but there is no clear-cut information about the payment mechanism so the government has to amend the policy statement to include a clear-cut provisions on payment and participation of human challenge studies and that is all regarding this discussion in this discussion we saw what is human challenge studies we saw the difference between human challenge studies and the traditional clinical trials and finally we saw the challenges associated with human challenge studies in India now with this let us conclude this discussion and take up the next news article look at this article this article talks about cell-free DNA according to the article cell-free DNA can be used for non-invasive prenatal testing which helps to screen fetuses for specific chromosomal abnormalities this is about the article given here in this context let us quickly go through some of the points related to cell-free DNA see in the human body most of the DNA in a genome is neatly packed inside the cells these DNA are protected from degradation with the help of specific proteins but in some cases some fragments of DNA are released from their containers and are present outside the cell they are present in the body fluids these small fragments of nucleic acid is widely known as cell-free DNA or CFDNA now moving forward let us see how this was discovered see scientists have been aware of such degraded fragments of nucleic acid in body fluids since 1948 but only in recent times that is since the genome sequencing technology advanced the CFDNA technology gained prominence because the sequencing became more accessible this is how the CFDNA technology has prospered in recent times remember CFDNA can be generated and released from a cell in a number of possible situation for example when a cell is dying and the nucleic acid become degraded the CFDNA can occur apart from this in a variety of process CFDNA can also occur for example processes those required for normal development those related to development of certain cancers and those associated with several other diseases CFDNA can occur these are the possible scenario that leads to the presence of CFDNA in our body fluids okay finally let us quickly go through some of the applications of CFDNA the first application is non-invasive prenatal testing and diagnostics to carry out this test a few milliliters of blood is obtained from the mother after 9 or 10 weeks of pregnancy using genome sequencing approaches scientists will sequence the CFDNA fragments that looks similar to the fetal DNA this CFDNA fragments can be used to understand specific chromosomal abnormalities this helps to ensure that the developing fetus is free from chromosomal abnormalities like Down syndrome okay see earlier that is before the CFDNA technology became widely available screening for such abnormalities would have required inserting a fine needle into the body of the pregnant mother to retrieve the amniotic fluid and the cells covering the developing fetus this is then analyzed in the lab see this method carries risk to both the fetus and the mother so CFDNA based approach has now become a norm for screening high-risk pregnancy this is the first major application of CFDNA technology another emerging application of CFDNA is that it helps in early detection diagnosis and treatment of cancer next the CFDNA technology helps in understanding why a body is rejecting a transplanted organ here CFDNA serves as a biomarker and it is capable of sending a signal earlier than other markers if something wrong is going to happen here what is a biomarker in simple words a biomarker is like a clue or a signal in your body that doctors and scientists can use to understand your health for example a simple blood test can reveal several biomarkers that tell you whether you have diabetes or risk of heart disease this is about biomarkers now moving forward the last major application of CFDNA is that it could also act as biomarkers for neurological diseases like Alzheimer's disease, neuronal tumors, strokes, traumatic brain injury and even metabolic disorders like type 2 diabetes and fatty liver disease these are the possible applications of CFDNA technology so in a true sense CFDNA genomic technology promises to set us to a path of more effective disease screening and early diagnosis and this in turn will help us develop a healthy world okay so that's all regarding this discussion in this discussion we saw what is CFDNA then we saw how it was discovered after that we saw how CFDNA occurs in the body fluids and finally we saw the applications of CFDNA technology now with this let us conclude this discussion and take up the next news article now have a look at this article this article provides an overview of Indian governments measure to support the domestic chip industry it gives us an overview of the semiconductor industry the article also discusses the challenges that the Indian chip industry faces this is about the article given here in our discussion today let us see some of the important points mentioned in this article first let us see why the chip industry is important for India the global demand for semiconductors is expected to grow significantly in the coming years due to the race of new technologies such as artificial intelligence 5g and the internet of things India has all the necessary ingredients to become a major player in the global semiconductor industry as it has strong talent pool and great demand for semiconductors India is a major hub for semiconductor design because 20% of the world's semiconductor design engineers are Indians okay now let us see what are the steps taken by the government to aid the domestic chip industry see in 2021 the Indian government launched the design linked incentive scheme this scheme provides financial support to domestic chip design companies and aims to indigenous the innovations in the domestic semiconductor design industry the goal is to create at least 20 companies in India with a turnover of more than 1500 crores in the next five years the design linked incentive scheme is open to Indian companies startups and MSMEs to be eligible for the scheme companies must have at least 50% of their employees as Indian nationals and must have a registered office in India another important thing to notice that recently the Indian government said that it would have a equity stake in the domestic chip making companies when a government has a equity stake in a company it means that the government will own a portion of the company share the reason is to support strategic industries the government aims to ensure a stable ecosystem by building fabulous companies here the fabulous companies simply mean the companies that design chips but outsource the manufacturing okay note that the semiconductor industry is capital insensitive and requires a long-term strategy according to experts governments attempt to invest in the shares of chip companies is likely to be ineffective and inefficient but still this equity infusion or the cash infusion by the government will be encouraging for the local small and medium-sized companies even though the government is taking many steps to strengthen the chip industry there are some challenges faced by these companies first important challenge is lack of venture capitalist there are very few venture capitalist in India from the private sector who mainly focus on the semiconductor industry secondly the cost of designing a chip is very high and this can be a barrier for new companies entering into the market despite this high cost of designing the annual revenue of domestic chip design companies is estimated to be only 150 crores this is very low revenue compared to the potential of India's talent and demand finally the higher gestation period in chip industry is a major challenge for it here gestation period refers to the time taken to develop and bring new chip into the market this period can be quite long often taking several years because of the complexity involved in chip designing due to this reason chip companies are not able to attract potential investors and venture capitalist into the industry like the software industry does these are the important challenges faced by the domestic chip industries so that is all regarding this discussion in this discussion first we saw an overview of India's domestic chip industry then we saw the steps taken by the government and finally we saw the challenges faced by the chip industry and with this we have come to the end of the news article discussion session now let us take up the practice problems questions we have four practice problems questions today let us see them one by one let us take up the first question let me read out the question it is a type of bail that can be granted to an accused person when the police or the investigation agency fails to submit its report about the accused person within a certain time period which type of bail is mentioned here from our discussion we know that the correct answer here is option c default bail moving on to the next question see here three countries are given the countries are Mali, Bernika Faso and Zimbabwe we have to find why these countries caught the international attention in the recent years see the correct answer here is option D successful coups all three countries mentioned here that is Mali, Bernika Faso and Zimbabwe witnessed successful military coups okay this is about this question now moving on to the next question here four statements are given we have to find which among the following is the primary objective of the central board of film certification from our discussion we know that the correct answer here is option c classifying films based on their content for appropriate audience this is the primary objective of central board of film certification now moving on to the last question see this is a quiz question for you and the question is based on our self-free dna discussion interested aspirants can post the answer for this question in the comment section the main questions based on today's discussion are displayed here interested aspirants can write the answers for the questions in the comment section if you like today's video like comment and share it with your friends for more updates regarding upc preparation subscribe to shankarae's academy's youtube channel thank you for listening


This is Quran from D5, I'm really excited to show you our smooth workflow with Revit. To get started, please install D5 converter from workflow section in D5 or from our official website. We have three Revit files, Streets file, Landscape file and our project file. In a typical Revit workflow, we tend to have multiple links that generate the whole BIM model, either to manage file sizes or to follow a certain standard. As soon as you open Revit, you will notice right away the D5 Render tab. You'll also notice three buttons available, Start D5, which itself is the main initializer to D5 Render, Settings and Export D5A. Before we start, let's get into the settings first. The first one is Use Survey Point. Now this is a very important option to activate when using linked Revit files. Especially if you want to have more freedom, editing each file separately in Revit and sync them back to D5, retaining their correct coordination system. Of course, those files should share the same survey point. The next option is Use Consistent Colors. The results in D5 would appear to be matching the consistent colors visual style in Revit. You can simply sync it as colors and then apply your textures in D5 directly. Lastly, the Export Smoothness. I want to bring attention to this option and how is it being misused by the community. Please do not increase the Export Smoothness unless you need it to. And if you want to have certain elements to behave smoother than the others, you may simply isolate those elements and export them in an increased smoothness. Alright, back to our example. Let's hit Start and give it some time to send data. And it's done. We can also sync our Revit cameras. Let's do that. Just hit Sync Cameras and your Revit cameras will be transferred as D5 Scenes. Now, we need to start assigning materials and placing some assets, either from the D5 Library or your local one. We are done. Now this project looks much better. And of course, if you want to make any changes in the project, you can simply hit Sync and your changes will be reflected back into D5 automatically. In this example, the design is good, but it looks like a bit dimmed. Well, basically there are no lights. So, we can either place those lights manually in D5 or we can use our already placed lights in the Revit model. To do so, simply hit Sync Lights. Great. Our lights are transferred into D5 and also they are organized based on the family type in Revit. For example, in D5 browser here, we can see that the lights are grouped in multiple groups. How did we do that? Well, in our project here, we have those lights separated as family types for about each two or three levels altogether. So D5 respects this. It's really up to your imagination. Thank you for watching this tutorial. We surely hope you'll be able to produce stunning renders with D5.