Let's get over to our man. It's the Tim wood folks as we do every Tuesday and Thursday and don't forget you can reach Tim is a great newsletter every trading day at odd or D hyphen oracle calm That's odd hyphen oracle calm Tim or what's going on brother? Well, I think you some charged over Yeah, you do it. Are you are you ready? Ready I've been ready since last week when you nailed this thing again Tim And you know you're looking at that s&p and it was halfway above the top Bollinger band and here we are on the fourth of March and a fifth of March and this thing's starting. So let's do it man All right. Let's look at actually chart one is what we talked about last week Okay, man, and that's that monthly chart, you know the yeah, they could sit above the upper Bollinger band And if you go to the second window up from the bottom There's a slight Actually that chart is the SPX VIX ratio with the Bollinger band on it Okay, yeah, and if you look at do the the right side the current time frame Yes, you made a the the SPX VIX ratio made a lower high While the SP's made a higher high ages at that blue arrow Yes, not a huge divergence, but still a divergence. So you had actually two diversions She had one on the SPX VIX ratio, okay, and also You're above the big percent above the mid Bollinger band or the upper Bollinger band and folks We're talking about 50% above the Bollinger band As you put it on your charts put it on the monthly which is even more intense This is on the monthly that Tim's talking about so pretty cool. Yeah. Yeah. Yeah, this whole thing's on a monthly chart Right. Oh, yeah, they kind of tell different stories on different time frames. So actually as we'll look at the Next chart, okay the weekly time frame. So you start off the monthly now We're gonna look at the weekly. Yeah, and it doesn't look bad at all. Okay if you look to the you know where we are right now or this last rally up, you know the Bix even though it's going sideways. It's still made a higher high On the SPX VIX ratio on the time frame there. So it's not like a Monthly chart, you know rules of weekly chart to weekly charge rule is daily charge. Yes So so my interpretation of this is you know, this is not a a major decline Nothing like we had back in if you look back in November of 2021 that was a major divergence. She had The SPX VIX ratio, which is second window up from the bottom making lower highs We don't have that here. So you still have a pullback, but there's not a big divergence. So I don't think it's any big decline Starting here and so let's flip to chart three real quick. Okay We talked about this last Thursday. Yes is updated to today and the third window up from the bottom is the 63-day average of the 63-day average of the arms index So it's like three months of arms index. Yes, and usually if you're above 1.1 You got enough panic in the market. You can have some pullbacks, but nothing real significant Oh, yeah, big big declines concur when you get down around point one and lower You were up to 1.1 to which is you can have a minor pullback here, but it's not set up for a major pullback So in yet term, you know the weekly SPX VIX ratio and the 63-day average of the arms actually look decent So nice, so let's look at now look at the short term and folks So just so you understand if you're driving in your car right now Remember the program's archive so you can go over this when you get home because these Different tools that Tim's use are just awesome, man. Okay, so I'm ready Tim. That's the next shot, right? Yeah, the chart chart number four. I have a daily. Yeah daily chart of the SPY and that blue area. I just want to point out that's where the gap is yes And I thought you know the first time we pulled up we go down and touch it and we didn't we didn't even You know come close to a market rally to anyhow and now We're awful close, but we're still not touching it I made this chart earlier in the day, but we did get a clue yesterday if you the bottom window is just the VIX and Yeah, the S&P's inner day was higher than the prior yesterday was Monday and inner day was higher than Friday And while that was going on the VIX is also making a higher Low as the S&P's was making a higher high And that's usually a various divergence are insured term basis Okay, and also the volume yesterday was anemic Yes, try to rally above Friday's high.  Yes, the previous swing low is a low We had last week and that looks like about five oh four approximately, you know and the and the Yeah comes in, you know probably about five oh three in the spot Yeah, and we've hit, you know, it's wilds and we've hit five oh four nine ten today So yeah, well How you test that gaps also gonna be important. Yes, so if you test, you know the gap formed on She wrote that date down, but I Know it's like two weeks The last one's like two weeks ago Yeah, about two weeks ago. Yeah, it's exactly Volume of that day as if you test that gap on on the day that bought the gap was created The volume of that day be tested on equal greater volume That won't be the final time you test that gap. You'll test it again If you test it on lighter volume 10% You know so say that day of two weeks ago with 100 million shares and today you tested on 90 million shares That gap's going to be support But if you test it on 100 million shares or even more You may may bounce, but you're gonna come back in and test that gap again, right? So I don't know what how that gap is going to be tested. I don't if we test it today, you know, I don't know if we got See update my chart here Yeah, we may I don't know. We'll probably test it this week. I don't know if we'll do it today or not But how you test that gap is going to be important and also and you know, you know, it's interesting Tim is that If we just I don't mean to interrupt you but if we go to the if we go to the NDX 100, right the cues So the spot the spy the volume is not that big today But the cues are coming into that gap right now And it's gonna have more volume because we've already done 45 million. I'm showing 52 When it gapped up But this is still early man, you know, we're talking. Yeah talking 20 minutes. They'll throw 20 million shares into the cues Anyway, stay right there folks. Tim and I are gonna be coming right back Tim will go through these charts for us We have the down industry was down for 92 Nasdaq off 321 S&Ps off 68. We're coming right back folks Welcome back folks. I tell my Brian Tim. Would we do appreciate your growling and problem with us out here We have the now a 515 Aztec's off 325 S&Ps are off 71 Tim's bring us through these charts, baby Okay, so I have the VIX the spy and the VIX up right now Tim Despite the chart number four. Yes. Okay. Yeah, all right There's a couple things was going to go on you know, you you were talking about the QQQ Yes, no on this chart. This is the SPY charge by circled on the volume charge two days there Yes, you know those two days I circled but the point QQQ works similar Is it's not exactly the rules of the S&Ps, but they do work similar So if you got a bunch of volume coming in on the QQQ today and the volume is 50% higher than the previous days before it it's going to stop that decline Okay, so because it's going to be a selling climax And so if it's a abrupt change either up or down in volume It stops it but if the gradual gradual change Either up or down is going to keep going. You know, it's wild now Hey folks, you're going to do this number man. This is so cool. It's unbelievable So check it out Tim. Yesterday, you know, as we both know and you just informed the whole audience We had light volume. So it's 34 million and The Q's could do 60 million today That's crazy Ian you have Powell we have Powell talking tomorrow in the next day, you know in the senate and the house So We get some volatility coming out. So just pretty cool Yeah, well, this is the week before auction expiration week two and this is where you get all the Weird stuff. Yeah, I get that.  Oh, actually word. Wally. We had Wally Wednesday Yeah, we're Wally. When is he with the ball and uh, uh, well and Chuck. Yeah Yeah, well and Chuck figure that you see he's selling the business too. So I love it I haven't interviewed him forever, man. I mean, you know folks said when in the 90s that I had I didn't have one that many times. I had him a few times because he's a wise guy too, man Yeah, yeah, he's a lot of fun to talk to. Yeah, so All right, but anyhow, I'm thinking My opinion right now is that we're probably going to touch the gap Okay, and how we touch that gap is going to be important and if you notice, you know, the market's Down a bunch, you know the 1.3 is we're putting it as we're talking right now And you got a trend right now 1.8. I know showing any and I panicked cat, but Did I lose it? Oh, go ahead No, can you hear me? Yeah, I have you. I have you. Yes All right Well, I'm saying was when the trend you know, you need at least or 1.2 to really get panic in the market And when we panic only forms at bottoms and a lot of times that panic just comes out of nowhere Yeah, you know, so but today we're not getting it They're not panicking today. They're buying today at a 0.86, right? Which is pretty wild, man. Yeah Yeah, so it may show, you know, it'll probably show up sometime this week But yeah, it doesn't appear it's going to be today or anything So I don't think today is the day of the bottom right right. So actually let's go to chart five. Okay This is the trend here the bottom window is a 10 day trend Next window up is a five-day trend next window up is a two-day trend um You at least need the two-day trend to get up around 1.2 and uh, so I'm thinking You know, they really get a buy single going for next week because I think expiration week Which is next week's going to be an up week. I would think you at least get a two-day trend up 1.5 we think that could happen this week. So we'll see if that develops or not Did he say a two-day trend at 1.2 or 1.5? Uh, say that again on the two-day trend. You like to see it at 1.2 or 1.5? Actually 1.5 is ideal, but I've seen 1.2 work. I see. Okay. Cool. I got it. Okay. Yeah Yeah, it's just kind of that's kind of a moving target on that two-day trend Yes, the end-day trend stage real consistent at 1.2 But the two-day trend is really bullish market gets down 1.2 and bearish markets. Sometimes you need 1.1 point 75 Okay, so you kind of watch what's happening over the last six months That's the reason why I got that one point. It looks like about 1.3 going across that two-day trend I see I got it. Yep. Yeah. See it works pretty good at 1.3 right now If you look at all that those are all with the bottom. That's what I'm looking at. I know that's pretty cool, man. Wow Yeah, yeah so but Anyhow, that's uh The trends not or the downtrend on the spx is probably coming close to a low But it's not a low today Uh And it may not be tomorrow, but sometime this week. I think you're gonna find a low so but not today And you know as tim said, you know, you know, we we got option expiration next week So I'm in Dave white. He used to love this folks setting up You know if you can get a nice low in and get the panic this week you can get some nice Calls of cheap money, man Yeah, yeah, I'm kind of for that thing too is When everybody's really blowing out the the trends and stuff is it's you know, the the higher the panic, I guess Yeah, the better it is because it's almost actually putting fuel gasoline on a fire Yes, so when it's really blows out because when that thing reverses they don't let you in right, right? As I mean it's a it's like a rocket ship out of these holes But it goes into kind of a minor panic Low it comes out A decent rally, but not you know, not like explosive But it goes into the hole of extreme panic it blasts out at market extreme volatility to the upside so I don't know which one we'll get get this week, but We will I guess we'll have to wait and see So We can move on if you want I'm ready. I just said the next one. Yep Church six we're going to go real quick here Well, I want to show is you know, I guess sir, uh, this is the uh, which church six is Okay, the inflation deflation ratio on the weekly time frame So this is common airman term type signals and the the the dark red circles are times When another indicator Uh gave a bicycle which is on page seven. Okay So all those dark circles in there are the exact times both those signals were created for for both so Well, I'm turning these are bicycles of different methods coming in the same time. Yes, and if you if you look in chart number eight Okay, and see you red. Sorry, which is the bottom window. I see it on the xAU Which is the weekly xAU gold ratio we had an rsi hit below 30 last week And those circles on the xAU bottom window there are the same signals generated on those two previous indicators. Wow And we got some good juice on gold this last three days, man As more signals come in on the same time. Yes So, you know, we've been kind of arriving kind of boys here over the last several months If you notice those previous bicycles really didn't fail. They just kind of went up and come back down You know, because really the market hasn't done a squat Since June of last year, right?  You know, I go up come right back down and go back up All right, but now you got three different signals of three different types of indicators Coming in and all them, you know, we still may move sideways here a little bit But we're probably at least near me a term low at a minimum. Yes, so We'll see how that all works out. But now stay stay right there, Tim We're gonna be coming back folks. We've got two more charts to go with Tim Uh, there's those girls also gonna be gold charts. We get the dial right now at 444 and Aztec off 297 S&Ps off 61 when I look at You know, my uh screen here is These golds are still in pretty good shape. Tim and I be gonna come right back folks Welcome back folks. We're talking about man. Mr. Tim Orton right now. We are talking Uh gold so I got the chart up folks at Tim All right, uh chart six Uh kind of one of them were briefly but this chart Gives a signal probably once a year And what it is an inflation deflation ratio rsi Um Any other the point I was trying to make that the The Circles bold circled areas. Yes our times Uh, which is, you know, we got one here, you know Last week or two Bold circles then we the last one we had was 2020 Yeah, 2022 Then before that was to get 2000 Um looks like about 19 and so anyhow, these signals are pretty rare Yes to get the rsi on a weekly time for him below that but when you do get it, they're pretty reliable Nice, so anyhow that that chart Uh, it gave a buy signal and this next one Chart number seven. Yeah, this is in play. It's the uh Uh, yeah the 50 day average, which is the bottom window seems to work best Okay, when the 50 day average of the up-down volume gets below 20 And turns up that did it back in axi late february and those bold uh bold circles on the bottom mirror the ones Of a chart number six, right? So so you're getting a double buy signal on this method So something totally different than what the first method was. Yes, and you flip to you flip to chart Number eight. Yeah, which is the weekly XAU gold ratio, right? So whenever when everything just goes in a dumpster This this is a chart that You know pretty much shines look at that in the bottom window Is that I circle those times. Yes, and that knows mirror the previous signal. So you got three signals All developed at the same time right in this vicinity So we leave that at least that amendment looking at any minute term low here We are rocking. We are rocking until thursday without man. Mr. Tim. Ord. Remember you can get hold of him at ord hyphen oracle.com Tim. Have a great one. Have a safe one All right, we'll see you Thursday. There's a have a great one folks come back and visit tommy tomorrow morning nine o'clock


So you're 29 years old. Yes. And you already have more than 10 million in real estate deals that you've done. A lot of people have been fascinated by this land arbitrage concept. Real quick, land arbitrage is when an investor buys property and then quickly fails after. Back to Talu Pass. What's three pitfalls? Deadly errors for people trying to do land arbitrage. Well the first thing is not knowing your area, not becoming an expert, their offers are too high or they're way too low. I think the second is you can't delegate what you don't know. Well they're delegating to like VA's. How about the hire of VA to come up with your offer? That's like a heart surgeon being like all right what nurse can actually do the heart surgery? Probably not knowing how to sell the land. Yeah they don't have the systems in place and then it takes them a long time to sell the land or they can't sell it for you know what they thought they could. I mean the opportunity is is definitely huge and one thing I love about it is it's very simple.


Do you ever wonder how they find out what planets could sustain life? Between 2003 and 2004, the Hubble Space Telescope looked further into the Universe than we have ever seen before. The result was a stunning glimpse of a vast cosmos that is way beyond human comprehension. We consider that among millions of galaxies and billions of solar systems that there must be life. We simply can't be alone in the Universe, but how will we ever know this for sure? Is it crazy to think that we may never even confirm for sure that we are not alone even though through sheer randomness of space we know there simply must be life in some form or the other elsewhere? Wait, do you hear this? So that is the question of all the billions of planets we peer at in the ultra-deep field image. How many will have life? Observing Earth's global biology on a massive planetary scale has given scientists the tools to answer important questions like how can we use models of our own planet to detect signs of life on other worlds? In short, the first thing to do is figure out how we would find ourselves. Only a few decades ago, talking about life on other worlds was pretty taboo to say the least. If you brought up talk about aliens or life on Mars, a few eyebrows would be raised. It just was not considered an important human subject, but that's all changed these days. We accept that it is impossible for life not to already exist elsewhere other than the Earth. Based on our understanding of how life operates on Earth, we are starting to derive principles of the signals that life creates that we could then look for on these planets around other stars. But how do we choose where to begin in our search for Earth-like planets, or planets capable of sustaining life in a universe as vast as ours? This is where the scientific approach is vital as we comb space for signals of life. The key to this lies with understanding Earth's climate over a long period of time. By understanding Earth, it gives us hope to search for another planet like the Earth in habitable zones of other solar systems similar to our own. So it fizzles down to where to look exactly in our solar system. The habitable zone, or the Goldilocks zone, as it is sometimes referred to, is bound by planet Venus, which is far too hot with no surface ocean and the planet Mars, which may be too cold and too small and lacks any life-sustaining atmosphere these days. So you have to be in the right size and in the right place. Consider the Moon. It too is in the perfect position, along with the Earth, and it gets the correct amount of energy from the Sun, but it is far too small to hold onto an atmosphere. Now consider Jupiter. It is too massive, and this puts an overwhelming pressure on liquid water to exist, which is the key to life as we know it. So this is why the Kepler space mission was developed. Consistently over the years, Kepler has been discovering Earth-like planets within a habitable zone of other solar systems. Cluster after cluster, the Kepler has now found thousands of planets that are the right size and the correct distance from their star to sustain life that could be similar to that of our own. Everywhere we look, whether it's a desert or Antarctica, or the deep ocean or the deepest parts of Earth's crust that we've explored, as long as water exists, life exists, and this is the key that we have been taught by Mother Earth. The more we see other planets, the more the question comes into focus. Obviously we're the weird ones. Decades of observing Earth from space has informed our search for signs of habitability and life on exoplanets and even planets in our own solar system. We're taking a closer look at what we've learned about Earth, our only example of a planet with life, to our search for life in the universe. If there isn't anything else out there, if we really are alone in the cosmos, then wouldn't that be a complete waste of the vastness of space? Just a thought. What do you guys think our chances are in our search for life elsewhere? Maybe aliens have already found us and are keeping an eye on our progress. If you consider the breakthroughs within the past 20 years alone, then the next 20 years will be exciting to look forward to. Wouldn't you agree? Comments below and as always, thank you for watching.


I am Sabina Aliyeva, the Commissioner for Human Rights Ombudsman of the Republic of Azerbaijan. I declare that within the framework of the Human Rights 75 initiative, I have taken on a number of commitments with my authority and represent at a high-level event held on the occasion of the 75th anniversary of the adoption of the Universal Declaration of Human Rights and would like to bring them to your attention. We, as an independent national human rights institution, will enhance the cooperation with the UN and other international human rights organizations for effective protection and promotion of human rights and freedoms. We will further strengthen activities to protect and promote rights of vulnerable groups of population, persons with disabilities, women, children, the elderly, prisoners, migrants and minorities in all regions of Azerbaijan and enhance our work in combating discrimination, promoting equality and actively participate in building of an inclusive society. We will intensify the efforts in cooperation with international organizations to bring clarity to the fate of nearly 4,000 of our citizens who went missing during the First and Second Karabakh Wars. To provide Azerbaijan with accurate information on maps of numerous mines and explosive remnants of war planted by Armenia in our territories during 30 years of occupation and the records of mass graves of our compatriots killed by First Messages and Buried in violation of international humanitarian norms. We will continue our efforts with the mandate of the embudsman for safe return of former IDPs to homeland and organize awareness-raising events with their participation. We will continue the activities to contribute to the reintegration process of the residents of Karabakh of the Armenian origin into the Azerbaijani society as well as to the return of Azerbaijani residents of Armenia to their homeland and reintegration into Armenian society also to promote peaceful coexistence among the two peoples. At the end, I sincerely congratulate the global community on the 75th anniversary of the adoption of the Universal Declaration of Human Rights and 10th December International Human Rights Day. I call on everyone to demonstrate solidarity without any discrimination in addressing global challenges for the hopeful future of our interconnected world and to make efforts in resolving universal human concerns towards an inclusive society.


This is the one o'clock Tiger Financial News Network Market Update with the Basel Chapman dowsdown 43 at 33,738, considering the PPI report and the economic reports out this morning so far is holding well, but it's starting to show signs that it is rolling over. So it has to hold the 33,500 level of the next couple of days. Looking at the S&P, the S&P is also pulling back somewhat after a rally attempt early on. It's up 1 at 39,64. Just can't get over the 9 and 14 period moving averages there. Also kind of struggling looking at the QQQ, which earlier showed a little bit more strength than the others. Still shows a little more strength, up 0.26%, up 73 cents at 284.57. It needs to get to the 289 area by Monday or Tuesday of next week, definitely not under the 279 area. Looking at the IWM, the Russell 2000, that is trading right now down 83 cents at 179.98. You've got gold, which was early on running quite nicely, sold you most of the gains up 9 at 1810, trying to get to a leg D above that high that was made just five days ago into the continuous contract high of 1822.90 to get to 18, let's see, that'll be, yeah, just checking that out, and that'll be 1823 will be a good number. Looking at the dollar, dollars at this particular point is holding just steady. That's up 6 ticks at 104.84, but in the lower range, testing a long term, I'll be doing Larry Percivento's hour coming up, and we'll look at some of these currencies to see what they're doing as well as some of the agricultural stocks. We're looking at the TLT, which are bonds. Bonds are pulling back sharply down over two points at 107.10, so those yields are just trying to go a little higher, they've had a really big slide, we'll see what happens after this, so and the VIX, the volatility index is trading at this particular point is trading up a little bit, it's up 16 cents at 23.45, not really going anywhere, you consider that the market's been pulling back for about five days, it has run from the 19 area to the 22s, but every watching this, if next week is still trading in the 23-24 area, this market will pull back. I'll be here for the next hour, I'd like to take your questions and buzz a trap and send you in for the hour that Larry Uri does.


Hi, I'm Mr. T. with RVelement. In this video, we'll continue with the topic of MIMO, multiple input and multiple output systems. If you haven't seen the introductory part, make sure to check it out first. In the intro to MIMO, we talked about single-user MIMO, where the pre- and post-processing happens on both sides of a link, the access point and the CPE. SU-MIMO systems work poorly in line-of-sight scenarios. To operate well, they need a scattering-rich environment, so the signal is reflected, scattered and diffracted from the surroundings, ensuring that the signals arriving at different antennas are not the same. In a MU-MIMO system, the pre- and post-processing only happens on the side of the access point, which communicates with multiple independent CPEs at the same time. There are two major differences between the single and multi-user MIMO on system level. First is the channel state information, or sounding. Before the link with each CPE can be established, access point needs to know how the propagation channel to each CPE looks like, so the access point sends the test data to every client station based on the predetermined knowledge of the test data. The client stations can calculate the channel response and send it back to the access point, which then uses it during the download for correct operation. Second, CPEs need to be synchronized for correct upload function. During the upload, the signals from all client stations must arrive at the access point at the same time. Since they are typically in different physical locations, the client stations need to know what delay to introduce such that the signals arrive at the access point simultaneously. Once the MU-MIMO system is set up, the links can be established. MU-MIMO systems typically use antenna arrays to maximize signal-to-noise ratio of signal each CPE receives. If you want to know more about antenna arrays, you can check our previous video through the link in the corner or in the video description. Depending on the number of the client stations, there is a corresponding number of independent data streams the access point works with. For each data stream, the antenna array is configured such that the main beam of the radiation pattern is aimed at the corresponding client station. So the individual setup of the antenna array is different for each client station. Since all antenna array setups for each CPE are known, the final radiation pattern is a sum of the individual patterns. Because of that, there is a limit to how many CPEs can be served at the same time. Minimum beam with size limits how close the served client stations can be. If the stations are too close, they are covered by the same beam and therefore cannot be separated from each other in a logical sense. To be able to do so, the beam width would have to shrink even more, which is possible by increasing the size of the antenna array. There are two major ways to determine which client stations can be grouped and served at the same time. First is to search for the maximum achievable SNR among all the client stations and picking those that have the best SNR available. Second is to search for the opposite, to find directions to which the nulls are steered to aim them at the CPEs that are not part of the served MU MIMO group. It is important to understand that the transmission of the signals to all CPEs happens at the same time and at the same frequency channel. During the download, each CPE receives all the signals containing all the data streams involved. Thanks to the signal processing techniques and the knowledge of the propagation channel characteristics between the access point and the client station, each of them can pick the data stream that is meant for them. During the upload, synchronized CPEs send their data to the access point, which again, thanks to the knowledge of the propagation channel characteristics associated with each client station and the signal processing techniques, then sorts through the signals received and separates them into individual data streams. If you find that video useful, consider subscribing to our channel, like or let us know in the comments what is your opinion on the maturity of MU MIMO technology in today's world.


We started with a primary focus on the challenges within Pakistan and Pakistan's future. And during the months as we worked, the crisis of U.S.-Pakistan relations became such that our emphasis on that issue grew even from when we began. Now in the context of other recent studies, we thought there was room for another effort that had as its focus priorities. What issues we tried to assess were the most important, what policy steps would be most catalytic in bringing positive change both to the situation within Pakistan and to the U.S.-Pakistan relationship. The relationship is no longer driven by the governments alone. And there are other complications. Given the nature of cooperation, the intelligence agencies on both sides have become big players. That's the nature of the current cooperation. And the intelligence agencies, as we all know, can be ruthless and self-centered. They have their own culture. And for the media, all that is going on in the relationship is stuff, dreams are made off. Pakistan has become an unending breaking story. That's complicating the relationship. And we have got to recognize these things. The United States aid program is actually enormous, and therefore, when it's cut off, if it's cut off, you know, the Pakistanis, the Pakistan economy will completely collapse and therefore the Pakistanis should do the right thing. It's the threat of cut off of aid. The fact of the matter is aid isn't such a big deal in terms of dollars. In terms of symbolism, it's a very big deal because the idea that if there's a cut off of aid by the United States, it'll lead to problems with other international financial institutions, which of course lend much more to Pakistan and perhaps other donors. So it's symbolic. I see this report as being incredibly relevant right now as we enter what I think needs to be a transitional phase and a reframing phase of our relationship with Pakistan and one that we cannot afford to have degenerate into divorce. I think the recommendations here, the measured ones, the 17 of them anchored around premises of transparency, openness, more societal engagement, leading with things other than CT right now because we can in fact do so given some of the successes we've had. This in a nutshell is what I would like to, as a panelist who enjoyed participating in this process, endorse as we move this report forward and hopefully look forward to it having some impact here in policy circles.


Dominoes is an incredibly successful, enormous company. But how did they become so successful? What can we learn from the success of Dominoes as investors and business people? Dominoes was one of the fastest growing stocks in the last couple of decades. Outcompeting made you fortune 500 companies. Did you know more than one million customers around the world enjoy hot, delicious Dominoes products every day? How did they become so enormous serving millions of customers on a daily basis? Let's look into this. Dominoes is dominating the pizza market. Simple pizza delivery service has gone on to becoming an incredible company containing unbelievable growth and is a brand that is super recognized across the world. Every person that's thought about running a business or wants to know more about running businesses can learn from Dominoes enormous success. In this video, we will go through the history of Dominoes, why they're so successful and what makes them stand out in a crowded field in the takeaway and eatery market. Dominoes has managed to achieve global recognition including within 90 international markets serviced by more than 18,300 stores and is generating revenue in the billions. But where did the successful company all start and why are they so successful? In 1960, Tom Monaghan and his brother, James, took to the operation of Dominix. They secured a $500 down payment as part of the deal and the brother paid $900 for the store. The deal was secured by a $500 down payment and the brother actually borrowed $900 to pay for the first store. So this was humble beginnings at the start. The brothers plan to split the work hours evenly but James did not want to quit his job as a full-time postman to keep up with the demands of this new fledgling business. They found themselves working long hours. Within eight months, James traded his half of the business to Tom for the Volkswagen Beetle they used for pizza deliveries. An interesting decision since now the company and market cap is in the billions. Dominoes started out small with just one store in Michigan in 1960, fast forward more than 60 years and Dominoes has grown to become one of the most recognized and leading pizza brands in the world. Here's a brief history of Dominoes through the years. In 1989, Dominoes introduced its first new product, handmade pan pizza. That same year, the 5,000th Dominoes store in the world opens. 1992, Dominoes rules out breadsticks, its first national non-pizza menu. In 2007, Dominoes introduced online and mobile ordering for customers making their experience even more convenient and more easy to order pizza. It goes without mentioning they became so successful because they adopted the franchise business model within the company's history allowing business people to set up their own Dominoes.  Although as with every fast food restaurant, strict processes and procedures are in place to maintain quality standards to ensure no matter which Dominoes you walk into, they will always maintain that quality consistently across the board. In 2015, Dominoes launched DXP, a delivery expert, especially designed and built pizza delivery vehicle launched across 25 markets in the US. The car holds up to 80 pizzas and features a warming oven as well as a storage area designed for easy loading and unloading pizzas on the menu items. Dominoes showcase a suit of innovative technologies called Anywhere that allows customers to order in more ways and on more devices than ever before. But we've talked about some of the success of Dominoes but it didn't always go to plan. There was some blockages in the road. The brand suffered. The company faced enormous backlash in 2008. Complaints started flooding in from customers about the pizza such as the crust seemed lacking. Pizza, where's the love? How are it? Bread, sauce, cheese, fresh ingredients. Doesn't feel like there's much love in Dominoes pizzas. Dominoes, pizza crust, to me is like cardboard. And they had a buildup to the crescendo of all these complaints such as microwave pizza is far more superior. President of the company decided to start a brand new marketing campaign called Pizza Turnaround whereby they started out the new fresh recipes and provided better quality. And do you want to know what businesses often fail to do? Offer total transparency, brutal honesty and realistic responsibility. They took it all. They earned all the negative comments. They ultimately and most importantly listened to the customers. You have to remember this is at a time whereby social media was turbo charging in popularity and this negative word of mouth was absolutely decimating the company. The company was effectively on life support and by Patrick Doyle earning Dominoes mistake and making changes, this is what saved the company is why the company is so successful today even in the year 2022. They changed everything. And when I say everything, I mean absolutely everything. The crust, the sauce, the cheese to make it tastier, more memorable and more importantly, not like cardboard but this wasn't done without hard work. Chefs were working day in and day out to find the best possible combination of pizzas they can find and not taking a weekend off. This was serious. The life of the company was being held in the balance by the product quality. Ultimately Dominoes invested in a customer centric approach of producing the right pizza. This is mentioned in their papers and values. They state Dominoes is a purpose inspired and performance driven company with exceptional people who are committed to feeding the power of possible one pizza at a time. At the heart of our brand is a set of values that define our core beliefs on how we run our business, treat our people, support our franchisees and serve our customers. So the key word in this purpose is that they listen. They listen to their franchisees. They listen to the customers and they listen to the people involved in the business. After this monumental change in product quality, they then went back to the customer to ask about that pizza, the new pizza. On the website you can see a range of tweets of this pizza turnaround and the positive impact of word of mouth. One of the best tools of marketing is known as word of mouth because it's free advertisement. You don't have to pay for it. Ultimately your customers are your advocate for the brand. The company was spreading through social media platforms through a wild storm like Twitter with largely positive responses about the new fresh, tasty pizzas. So what did Dominoes do? They made a massive change. They reimagined, reinvented and rebranded themselves to become one of the best places to order pizza in the United States, United Kingdom and many countries across the world. So what can we learn from this as people who are interested in business? Firstly, it's the ability to listen to the customer, understanding the customer's needs and responding to customer's complaints. This has made the product and service better. These are paying customers. You and I are the lifeblood of this company. No customers, then there's no business. So the fact that they listen was the crucial success of this company. The ability to deliver efficiently and update you on the delivery journey every step of the way because it's not just about the product but it's also how quickly the product gets to you and they aim for 30 minutes or less. Another reason for success is the product itself. They keep the menu complex but simple at the same time. Being able to customize toppings and choose one of the unique pizzas and even desserts. Finally, and most importantly, it's the marketing. Listening to customers, obtaining positive word of mouth. Dominers are also very good at communicating their offers for pizzas, enhancing both customer acquisition, obtaining new customers and customer retention, having customers come back again and again. Now, what can we learn as a potential business owner or someone who runs one? It's important to listen. Don't underestimate negative word of mouth and understand that brand is king. Thanks for watching on screen now. You can see another interesting video. Consider clicking on it. Please subscribe and smash the like button for more business related content.


I'll put a ring on it, this is all for Lou. I'll say. Lou, are you gonna put her, Lou, are you putting her, are you breaking news for us here? Listen, you're putting a ring on it. If I think you were listening to country music. Your day, I put a ring on it. I love that. Anything will be breaking news to all of us. You're gonna give it to, you're gonna give it to run it back, right? You'll never get that scoop shot. Wait, no, give it to me so that I can scoop shot. It won't be a scoop. Fine, it won't be a slide then. All right, player's name gonna say over under how many rings they're gonna finish their careers with and yeah, we'll go from there. First up, the face. This is so hard. It is very hard. Anthony Edwards, 22 years old, we know this coming up in the first All-Star Appearance. Over under for Anthony Edwards, Chandler, you first, one and a half rings. I'm gonna say over, I love him. I think he's so young. He's gonna be so good for a really long time that Tim Wolves are building something over there. And again, championship, who knows what he does at the end of his career. 12 years from now, who knows. You know what, I'm gonna believe in this guy. I think he's one of the most entertaining and best two-way players in the NBA. I'm going over for Anthony Edwards. Over? I like over as well. Puts the work in. Great personality. Everything that you can imagine in a young guy that you would want to start a franchise with that you'll wanna build around. I'm going over too. Let me ask you this. Is it the Tim Wolves championship that he's gonna be bringing or is this gonna be somewhere else? Six months ago, I'd say no chance.  You look, the thunder are gonna be in their way for a long years to come. The Spurs are awful this year, but they're gonna be building. What's that? They're gonna be really good soon. And then you have these older teams where we have kind of the end of, you know, these guys that have been in their, their, you know, there's still really good teams out there. So I don't know if it's gonna be in Minnesota. I don't know when it's gonna be. I just like him going on or over. He's so young and he's so talented. At least two. Okay, Jokic. We already know. He's got the two MVPs this season. I spiraled there. He's got, you did. It's gonna be three probably. He's already got one championship. And it looks like very well. It could be on his way to another. Lou, you first over under two and a half for the Joker. I'm gonna go under. What? He needs two more. He needs two more. I'm gonna go, I mean, it's only so many rings. So we're gonna give two to that, man. We probably gonna give a couple more to Jason Tatum. Give one to James Harden, baby.  I don't know. Hold on. No, I think there's still, I think that group is still in there, bro. Yeah, a couple more to Jason Tatum. No, well, get away from James Harden. No, he did. He mentioned him. He said James Harden, too. I'm just looking ahead. He did. I'm just looking ahead, Shams. I think this is the prime. I think this is the best we're gonna see this team. I could be totally wrong, but I just feel like that window is gonna start closing as these other teams start to get better and better and become more competitive. So to see him get two more, I can see him getting one. I don't see him getting two and a half more. Okay. Yeah, I think under two, and I also don't think he's the type that's gonna ring Chase. He's not gonna go sign on a good team later in his career. He's literally gonna ride off of this.  So yeah, I like under here, again, that's no knock. It's just we're two more teams. We only have so many years. And how many more years has he got playing? Yeah, I mean, so I gotta go under here. That's fair. Okay, so then we'll get to Tatum. Obviously does not have one yet, 25 years old, six year in the league. He has made it to four Eastern Conference finals. That could be a good or a bad, depending on how you look at it, over under one and a half for Jason Tatum. Over, I think he gets one this year. And then I think he still has, you know, eight to 10 more years to find another one. So I think he's again, he's an Anthony Edwards type talent where he could do everything on the floor. He plays defense. He's gonna be in the MVP talks every single year for the next, you know, however long he plays and stays healthy for.  Celtics were a pick in preseason and there's still my pick right now. I got over as well, you know. And like I said, that's the only knock that I have for the Joker. I think these young guys that are still trying to find their way to get over that hump, I think they put a lot of pressure on him to get rings. I think Jason Tatum is gonna be one of those guys. Do you want us to take a break while you drink and throw things in the trash loudly? Is there anything else you need? Lord, I don't get it. Cause I know what we're talking about. There's only so many years unless these guys all jumped on the same team. We're running into a math problem. But you've got Jokic, who already has one and in a good position, having the same amount as Tatum when it's all said and done. I don't see it. Well, I think just the Celtics right now, we've been talking about how this is their time. They've been to four, you said they've been to four, you know, Eastern Conference finals. I think this is their year to get one. So I think he's gonna play a really long time. You know, I think he's got a lot left in the tank. So again, there's so many young teams, the talent is so high right now that I think the young guys almost have an advantage. And Jokic, it's more like a personality thing. Like I said, he's not gonna go and pop on the thunder in five years. I mean, he's just, he won't do that. All right, Harden still chasing that first one, guys. Over, under 0.5. I got over. Gonna get one. Yeah, the clip was on my pick for this year. I think this is the year that it happened. So I got over. I think over too, because I think he is the type of guy that will go and get it.  So I think he will find a way to get it. I mean, we're running in some math issues here. So let's see where we're going next. Well, by the way, they could eventually, these guys could get it on the same team. I was thinking that. I was like, what are they all? Like, James Harden, you go to the Celtics next year and get it. That could happen. You know what I mean? Like it's... It's not unheard of. Luca Ringless, so far, has made it to a Western Conference Finals. He just turned 25, Lou, over under one and a half. Now we're running out of time. Now, the math, the math. That one's tough. I'm gonna go under. Because one is good. Yeah, I'm gonna go under. One is good. And you know, I would like to see the new ownership group come in and put some assets around Luca that gives him, you know, a clear cut opportunity to win championships. Right now, I feel like they're a competitive group, but obviously other teams are trending up, you know, so I got under. This is the test for Chandler. He wants to stay over. I mean, it's so hard. I'm going over. I think, again, I don't... We're kind of just throwing these championships around there, like they're candy, but... We're like nine years old. I like over. I think he's such a... He's trying to be mindful of the math. He's such a good talent. New ownership, they're gonna continue to build that whole franchise. They're gonna build a new arena. They're gonna make Dallas and New Vegas. And Luca is gonna start getting more talented teammates. This is one of the better teams he's been on this year. They're gonna continue to be contender this year, but I think they continue... People are gonna want to play with them. What is this, year seven for Luca? Is this year number seven? Is it? If I'm not mistaken, it's six or seven. That sounds right. Yeah, she's a kid. We are now at year, I think, eight, according to your math. Everybody gets one. You get one. Yeah, well, because we still have SGA, by the way. Over, under, one and a half. And now we're gonna be at 10 seasons. Under. Okay. I don't know why. I just see there's not enough. Because you gave over to Luca, probably. There's not enough. I have an over left. Unless half these guys join up and they go on the same team, like we said on James Martin. I've got an over left, so I don't have to shake you. Here's the problem. He should be the most obvious over, because he's on the youngest best team, arguably, in the NBA. So if they continue to build this, they don't lose guys at free agency, Chet continues to grow. So what's your pick? Over or under? Because you've said both. I don't know, Lou. Under, under. Under for Chandler. There's too much talent. Over for... I'm going over. Yeah, you're sticking with your SGA. And you're sticking with your Luca.  I can't complain. Shoms, did you care about anything they just said? I think they were on point with that. No, you're the worst. We're just passing out championships over here. You all won. Shoms, we get over it. Over, under. Lou, you said James Harden? Yeah, I said one. Lost me. I hope James did one. Unless he jumps up. We all won, James. Clippers are my pick for this year. I can see James Harden going back to the Thunder. Ooh, hot change for tomorrow. You got hot change on the show, what? See y'all.


Yes, we live in a so-called obesogenic environment, cheap junk food everywhere, thanks in part to subsidies going to the food industrial complex, which manufactures obesogenic foods that foster addiction. The root causes may make obesity difficult to escape, but look, a lot of people do. If it was just the external environment, why isn't everyone obese? Some individuals seem to be more susceptible than others. This suggests a genetic component supported by studies of twins and adopted kids, but the genes we've identified only account for maybe 6 to 11% of the variation in body mass index between individuals. So maybe variation in our other genome may be playing a role. All the different microbes that inhabit our body. We have a hundred times more bacterial genes inside us than human genes. What this study found is that people tend to fall onto one of two groups. Those who have lots of different types of bacteria in their gut, so-called high-gut bacteria richness, and those with relatively few types, and those with low bacterial richness had more overall body fat. Insulin resistance, the cause of type 2 diabetes, high triglycerides, and higher levels of inflammatory markers, like C-reactive protein, compared to high bacterial richness individuals. And not only did folks with lower bacterial richness start out heavier, but the obese individuals with lower bacterial richness also gained more weight over time. The question then becomes, can a dietary intervention have any impact? They try to calorie-restricted diet, which by definition is very sustainable, but what we can do is increase our fruit and vegetable intake, which is associated with high bacterial richness. One of a number of studies that have associated increased microbial richness, with diets higher in fruits, vegetables, and fiber. And now, just giving fiber-type supplements didn't seem to boost richness, but the compositional complexity of a whole food, like whole grains, could potentially support a wider scope of bacterial types, thereby leading to an increase in diversity. But human studies to investigate the effects of whole grains have been neglected until now. Folks were given whole grain barley, brown rice, or both for a month, and they did cause an increase in bacterial community diversity. Therefore, it may take a broad range of substrates to increase bacterial diversity, and this can be achieved by eating whole plant foods. And the alterations of gut bacteria in the study coincided with a drop in systemic inflammation in the body. See, we used to think that the way fiber and whole grains helped us is by gelling in our small intestines, right off the stomach, slowing the rate at which sugars are absorbed, blunting the spike in blood sugars, one might get from refined carbs. But now we know the fibers broken down in our column by our friendly flora, which release all sorts of beneficial substances into our bloodstream that can have anti-inflammatory effects as well. So maybe what's happening in our large intestine helps explain the protective effects of whole grain foods against type 2 diabetes. And interestingly, the combination of both barley and brown rice worked better than either alone, suggesting a synergistic effect. This may help explain the discrepancy, the health effects of whole grains obtained in population-based versus interventional states. You know, observational states strongly suggest that those who consume three servings of whole grains a day tend to have a lower body mass index, less belly fat, less tendancy to gain weight. But recent clinical trials where you randomize people to like eat white bread rolls versus whole wheat rolls failed to provide evidence of a beneficial effect on body weight. Of course, whole grains are so superior nutritionally that they should still continue to be encouraged, but maybe the interventional trials failed to show weight benefits because they focused on a limited selection of whole grains, while in the population-based states subjects are more likely to consume a diverse set of whole grains, which might have synergistic activities.


All right. Well, thank you. Thanks for the opportunity to present our work today. So one of the first analysis challenges when you sequence a new cohort of cancer patients is to identify significantly mutated genes that are mutated in more patients than you would expect by chance. This is not such an easy task. There's many subtleties. A number of individuals in this room had developed very sophisticated methods for doing this statistical test appropriately on a gene by gene basis and then applied these tests to TCGA and other large data sets, thereby identifying a number of significantly mutated genes. And I put a list of a few of the more recent studies from TCGA. And while these genes seem to be enriched for cancer-causing genes, these do not seem to be the complete list of cancer genes in these samples. These lists are relatively short. And what I'm not showing you is the long tail of genes that are mutated at, you know, modest or rare frequencies, but don't pass this threshold of statistical significance that one would use. Now there's many reasons for this mutational heterogeneity, but one of them is that genes don't act on their own, but rather act together in pathways. And when you look at the mutations in known pathways, you indeed see such clustering of mutations in pathways. Again, showing you some examples from some of the TCGA studies, and thereby showing that we can recover some of the cancer-causing genes by knowing something about the biology and looking at how they interact with other genes. But as the data sets get larger, my group has been interested in developing ideas that allow us to drill a little deeper into the data, not restrict ourselves to only known pathways, but rather to sort of reduce the amount of prior knowledge we put into the analysis, thereby possibly identifying novel pathways or crosstalk between pathways or perhaps use something about the topology of these interactions. So of course, as we reduce the amount of prior knowledge and perhaps go to, you know, a noisy whole genome interaction network or even try to look at all combinations of genes and whether or not they're significantly mutated, we're going to face the statistical problem of increasing the number of hypotheses. So it would be very hard to obtain statistical significance if we couldn't even do it for a single gene. So we've developed a couple of algorithms that allow us to use some additional information and some tricks to kind of get this statistical robustness. First, you're looking at subnetworks of an interaction network, an algorithm called hot net, or alternatively going sort of deeper into this no prior knowledge, but we use this notion of mutual exclusivity. I'm just going to tell you today about hot net and to just briefly recap what the goal is. So we assume that we've taken our mutation data, collapsed it at the level of genes. We have a whole genome interaction network in a very simplistic format here where we've got genes or proteins and an edge between two genes. If there's some known interaction between them, we could of course use varying amounts of prior knowledge in constructing such a network. I'll tell you the ones we used in the analysis in a couple of minutes. And so the goal is to then identify connected subnetworks that are mutated in more patients than we expect. So you can see how this sort of generalizes a little bit this idea of looking at known pathways where if we think of this network as say the superposition of all known pathways, then we're sort of simultaneously trying to pick apart these pathways but allow for crosstalker interactions between them or perhaps novel subnetworks that we don't know a priority. So in developing such a method, there are really two components and there's this interaction between these two ideas that needs to be dealt with. One is that genes can be significant on their own. They have a frequency mutation or perhaps some score, maybe some significant score that you use, as well as the topology of the interactions between them. So we'd like to identify for example cases where the individual genes might not be significant on their own. They're mutated at moderate or rare frequencies but they're very highly connected. And perhaps distinguish those from cases where we do have genes that are connected to each other. Maybe they're even highly mutated or highly significant but that connection is through perhaps some high degree node which isn't so surprising then that we would find such a connection. And biological networks have this sort of uneven topology. So we need to simultaneously account for both mutation frequency or score and the network topology. So one way we can model this has this nice physical interaction that I can describe as thinking of the mutations as sources of heat on the graph. So the idea here is that we have this interaction network. We heat up the genes in proportion to their frequency or their mutation score or some notion of significance at the gene level. Here you can use a variety of different scores. And then that encodes the mutation part and then to encode the topology it allows that heat to diffuse over the edges. So this encodes both the local topology not just nearest neighbors but neighbors of neighbors and it does this in a very continuous way. So now we have this distribution of heat on the graph. So how do we get the subnetworks? Well we need to break it apart and the way we break it is by removing cold edges. And then we have to do a statistical test on top of that which I won't describe but has been published previously. So that's hotnet. And in this study what we wanted to do was apply hotnet in the pan cancer setting. So to go across multiple cancer types. And the idea here was that what we would like to find in doing so is perhaps universal subnetworks that were mutated across all cancer types maybe sort of with equal frequency somehow or perhaps once they were mutated only a subset of cancer types or maybe even cases where the subnetwork itself is mutated across all cancer types but the individual genes within that subnetwork are mutated with some cancer type specific biases. So we didn't know which of any of these things would arise and so we decided to go and look. And the story I'd like to tell you for the next six minutes or so is that we took a very noisy interaction network and we took all the mutation and copy number data threw it into hotnet and magically we got the right subnetworks. Unfortunately although the algorithm is nice it doesn't yet perform magic. We can't take all mutation data and copy number data. There's just too much noise there. So we have to do a little bit of filtering. We try to do as little as possible. So for single nucleotide variants we don't have to restrict to just significantly mutated genes. We can go really far into this distribution if you will. Here we used to cut off of only .8% frequency of mutation and that reduced some really low frequency mutations. Copy number aberrations of course are much, much trickier because they tend to be large. They include many genes and really identifying the target gene is a really difficult challenge. And we ended up using agistic max peaks that were predicted for the individual cancer types and then merged those together in a pan cancer analysis. The interaction network though we are able to use sort of a very noisy interaction network as I'll show you. So with some modest filtering on the mutations, here's what we obtained. So in total 1984 samples across nine different cancer types here, colorectal I've combined as one. Breast cancer I've split into four expression subtypes. So there's a number of samples of each type and 765 genes after we remove these low frequency mutated genes. You'll see some of the usual suspects have either high single nucleotide frequency or high copy number frequency there. But then there's also sort of this big smear of genes that are very low frequency. So the first interaction network is a very noisy one. It's this IREF index 200,000 interactions, over about 14,000 proteins. This sort of incorporates a lot of different interaction databases. So has a lot of false positives, presumably also a lot of false negatives. Note that there's no sort of temporal context here or subtype context. So this really is a very noisy thing. But we were able to pull out 11 subnetworks with at least three genes. And the p-value is at least 10 to the minus two. We haven't sort of finished all the permutation tests, presumably much lower than that. So here's a list of these subnetworks. And I'm going to show you a few in the next few slides, but not surprisingly, some of the usual suspects. Again, P53 signaling, PIC3CA, GFR and other receptors, RB1. This is a DNA damage subnetwork that I'll show you. P10 cohesin, I'll show you in a second, as well as a few others. So just to sort of show you some of the data, sort of a very dense plot. So here's the genes, their frequencies across the different subtypes, color coded by subtype, as well as whether it's a single nucleotide variant or an amplification in that sample. This is PIC3CA and RAS. What we also do is we sort of compute whether there's enrichment for individual cancer types in this subnetwork. These p-values you should take with a grain of salt, because we have thrown out some of the mutations. We filter the mutations, but it does show at least some trend of maybe some cancer-specific biases in these subnetworks. And then we also do see whether these conditional on the number of mutations in this cancer type, whether there's any gene-specific biases. Here you see that N-RAS is sort of preferentially mutated in AML, while K-RAS is preferentially mutated in colorectal, the luminal A subtype breast cancer with a PIC3CA mutation. I wanted to also note that, you know, there is a strong pattern of mutual exclusivity, but there's also co-occurrence that's allowed here. And in fact, although PIC3CA and the RAS genes are often thought to be mutually exclusive, there is some evidence that they do co-occur in particular samples, and we see that here in endometrial and colorectal. Here's this DNA repair, a network, same type of story here, centered on BRCA1. These two genes here are actually Fanconia anemia genes, which are genes that infer a genetic predisposition to this DNA instability disease. So it's sort of nice to find them here, very rarely mutated, would not be sort of found on their own and seem to be across cancer types, although there is some enrichment for breast cancer and ovarian for this subnetwork. Here's cohesin, which falls out. And in fact, we get the subnetwork is exactly the cohesin genes, and no more, five. So this is the canonical cohesin complex involved in sister chromatin adhesion, as well as more recently seems to be implicated in more general gene expression roles. We see, again, some gene specific biases in AML and a little bit in GBM for individual parts of the cohesin complex, and perhaps some cancer specific biases in different breast cancer subtypes for this complex. Another one really fast, these polycomb group genes. This subnetwork has a few sort of strange things that are driven by copy number, but what we do see here is this two components of this PRDub complex, involving BAP1 and ASX01, a little bit of gene specific tendencies for mutation ASX01. BAP1, of course, recently shown to be an important gene in renal cell carcinoma, so not surprisingly, there is a kidney cancer enrichment for this subnetwork. We then went and did another run on an additional interaction network. This one is a little more focused, tends to be literature curated interactions. So a smaller number of interactions here, only about 40,000. We pull out a larger number of subnetworks, 20 with at least three genes. Again, a good p-value, here's the list of those. Many of them are the same, or similar, not exactly the same, but similar type of story. Here's one with ARID1A and PBRM1 that I didn't know before. This is actually a version of this, is currently in Kirk, and this was identified mostly in kidney cancer. Notch was in the OV manuscript, identified by HotNet. And here's a nice one that's new, slit robo signaling. Here it is, we see again, most of the slit, we see both the slit lig in the robo receptor and this SIRGAP1, the ROGTPA. So we're getting sort of the complete part of this signaling network. Not too much enrichment here across cancer type, seems to be sort of across different types of cancers except for AML, hardly anything in AML in slit robo. Interestingly, we were sort of doing this analysis a couple of months ago, without knowledge of a paper that of course many of you now know. Some in the audience contributed to this paper that came out in nature just two weeks ago that highlights slit robo signaling as important in pancreatic cancer. Again, some of these same genes, although also including robo3 in that analysis. So we're pulling this out of the TCGA data types, again purely computationally, not in any directed fashion. And so we sort of view this as in some sense a validation of our computational predictions. So with that, I'll conclude and I'll just say that in summary, we took hotnet, which had been previously applied on individual cancer types. We applied it in this pan-cancer setting. We uncovered some evidence for perhaps these individual types of things that could happen, a little bit of gene specificity, nothing of course this dramatic where the gene is exclusive to a cancer type, but perhaps some such tendencies. Of course, there's only a first analysis. The mutation data needs a lot more QC. We're still struggling a little bit with copy number aberrations and how to do those, get a better background models for the single nucleotide variants. We haven't done anything with expression and of course it's important to incorporate expression, a methylation, we'd also love to incorporate as well, but each of these data types requires itself some analysis, you know, you can't just all go into the algorithm and pull out the magic. Dendrix, I didn't describe for mutual exclusivity so that will be something to come. And I'll conclude with the acknowledgments. My group, Fabio Mendina, you've all my colleagues contributed a lot to the algorithmic developments and my students, Max Lysers and Sinti, we've been doing a lot of the analysis. For the AML data, we've been working a lot with the AML group at WashU and I didn't describe the AML results in particular, but that curated data went into this analysis. The algorithms are available. We encourage you to download and use them if you'd like. We'd also be happy to collaborate and work with you and tuning them to your analysis. And with that, I'll conclude. Thank you, thank you, Ben. Questions? Matthew? Sure, so, Ben, really fascinating talk. I think one of the really interesting things is this sort of novel generation of new candidate pathways, which looks like it's corresponding in some cases to other recent studies. And I just wonder if you have a vision of how to move from definition to validation of these pathways through orthogonal datasets which would both bring more power to the approach and also allow you to refine it. I mean, in brief, I get asked that question. I don't have a good answer. I'm not an experimentalist. We'd love to validate some of our predictions. We've talked to individuals about ways we might do that. It's a tricky business because there's all sorts of crosstalk between these and we pick out one component and the experiment that you would do, that would say it's somehow the pathway or the subnetwork that's important as opposed to the individual genes is a challenge. So, I'm likely, I mean, you, I'm sure, could give a better answer than I could for how to do this. And I'd love to sort of talk to you about it more offline. If I had a better answer. One more. Yeah, computationally speaking, I think this is a very nice model. It's very similar to the, like, when people analyze the gene regulatory network across different species and also, like, protein-protein interaction network. So, regarding to the model, on the graph model side, so, since this will be handling very large graphs, right? So, very large, huge graphs. I think a specific graph property, like, related to small degree, or even, like, trivial approach could be applied to kind of improve the efficiency side. Sure, so, yes, the graph is large. It's really not that large when you talk to people that do, you know, internet graphs and stuff. The heat diffusion encodes a lot of the types of things you're talking about in terms of small degree and, you know, small worlds, power law, all that type of business. It's, you know, in many of the approaches that look at those type of graph topologies can be modeled in terms of the heat diffusion or random walk. I mean, there are really just different ways of looking at the same types of things.  No, I mean, there is some issue of scaling that we're running into that as we make the, as the data sets grow, so that the difference between the highly mutated genes like P53 and the low mutated genes, that, you know, difference gets larger and larger than, you know, there do become some issues in how you deal with that sort of difference in scale. And that's something that's come out of this pan-cancer analysis that we hadn't really had to address before when we had 200 samples. Yeah, thank you. Ben, thank you. I think, unfortunately, we have to move on.


This is covering the spread part of the Fandall podcast network After a weekend of pure chaos from start to finish We get to close things up with two teams that have definitely never frustrated us in the past It is a cowboys at the buccaneers to round out wild card weekend ready to break down our thoughts on that game Get you said for the contest wrap-up wild card weekend to let you know where we're seeing value right now Over at Fandall sportsbook. This is covering the spread right here on the Fandall podcast network and number fire calm My name is Jim Sadas. I am a senior writer and analyst for number fire calm joined here once again by Ryan Williams Check him out on Twitter at Ryan Alexander underscore W Ryan. We're getting pumped for tonight's game But that's late a game this weekend was bananas. How are you doing today? Oh? I'm doing well.  I mean, you know shout out to the Miami Dolphins yesterday Scholar Thompson the receivers let him down 100% But you you know, you you just love to see when you know those high totals or high spreads I should say Can you know be alleviated by some some good play and any any given Sunday any given Saturday Thursday? Whenever they're gonna play the games Jim This is why they play the game because you never know what can happen. Just ask the Vikings I was very much with you on the Trevor Lawrence thing on Saturday Because I had the Jags money line and so like I'm just like okay Mark, this is a loss. It's whatever and it was like I tweeted one point after he threw his fourth thick I was like, you know, he's just trying to drag down their wind telephone next year And it was like kind of like copium for me And it was like that that meme where it's like the person like pulling the happy face away And you can see that they're like stewing underneath the the happy face That was me tweeting that out and then all of a sudden it's like oh They do it they doing some stuff here and I was positive they were going to miss that field goal like I was like I know how That's right, like I I was like, okay, I took the money line if I had taken two and a half I wouldn't have to worry about this I just worry about a block kick which I was like, you know, also kind of because I had them in a teaser as well And I was like, okay, if it if it settles on eight, you know, that's that's not that's not ideal It's not the end of the world ideal but like I Feel like this is gonna be a mess and I was just like it was Doomsday, but like, you know, I was like, okay, they gave me a fun ride at least it was a good game I got to enjoy that the kick went through and I was like, okay This is this was a great day and like that's not the first time that's happened with them I had their money line the Ravens game where they had that comeback the the Cowboys game. So Luckily, I ran by numbers for next weekend. No value in the Jags against the cheese So I don't have to worry about that because they're just an absolute buzz saw that I don't want to deal with So I think that that's a relief to me. But honestly That game despite being like very clearly the best game like all the other ones were great, too And it's not just because you know having like money on the Jags and stuff like that But that was just a fun weekend overall And I hope to get to run it back and next week and honestly Ryan like looking at the quarterbacks and play next week We might get to run it back again with more fun there, too Yeah, I mean just looking ahead, you know, you look at headlines here Jags plus eight and a half 93% of the money coming in on the Jags 73% of the bets Bengals plus four and a half on the road against Buffalo. We know what that game is going to mean in general 85% of the bets coming in 68% of the money and then Giants in the Eagles, you know We get a we get a divisional matchup in the divisional round of the playoffs Giants plus seven on the road They're getting a bulk of the money to 69% So, you know the early the early shot bets are coming in on these teams all on the road actually Where people are loving loving getting action there. So that'll be a phone one to discuss next week Yeah, I've got the Jags chiefs game at seven and a half right now in one model and the other model It is at seven point eight. So not enough value to eight and a half meter to bet and I am delighted about that I don't want to worry about that, you know No action is good action as evidenced by that that Vikings Giants game for me on Sunday as well.  Yeah, but you know, you had the over that's you know, one for one or one for one for two You know still counts for sure We'll see we'll talk more about that on Thursday show to get you set for those But today we're gonna break down cowboys versus bucking ears and let you know how you can finish off your weekend Hopefully on a high note But first a reminder to make sure you are subscribed to covering the spread wherever you get your podcast big week ahead We've got our work our Divisional round first look is coming up tomorrow. We'll have that and also we'll talk some PGA batting with Brandi Gaduola NBA and NHL on Wednesday with Tom Vecchio We'll have Ryan back on Thursday to break down the divisional round and then on Friday. We will be talking player props. So That is the week ahead here on covering the spread a lot of good stuff As always to get it as it is posted make sure you subscribe to covering the spread wherever you get your podcast And also check us out over on the fan duel YouTube page also for tonight If you want some DFS action the NFL Monday million is live on fandal for the cowboys versus bucks Just pick five players stay under the salary cap and compete for your share of one million dollars in total prizes including 200 thousand dollars to first place all of that We're just a nine a dollar entry fee to get yourself entered download the fandal app or go to fandal.com Eligibility restrictions apply now Let's dig in here the cowboys at the Buccaneers We'll talk about the markets in a second right now Do the cowboys as two and a half point favorites the total of this game is still hanging at 45 and a half right before talk But those specifically what is your top-down view of cowboys versus bucks? My top-down view well we talked about this earlier, and I just don't know at me I do know but it's Brady at home in the playoffs You know the number at two and a half there then the bucks getting two and a half points Sure, I mean I guess that probably feels appropriate when you look at how the season's been going But I mean when you look at how Dallas has been playing down the stretch and like you know What McCarthy showed us with this team in the playoffs this far? I just don't know how you can think that they should be Necessarily favored like it should be more of a pick them to me in this matchup Maybe you know what one and a half is where I'd feel comfortable about it But if this is gonna be a one possession game let alone just needing a field goal like at home Brady gets the ball last minute like I You know there's just so many different scenarios where I could talk that in also just in general with the way that this offense has been playing You know the past couple times they're hitting their stride at the right time And this is the reason why Todd bowls probably let the starters play a little bit in week 18 Just to make sure that they were fresh here to be able to handle business the Dallas Cowboys on the other hand They've been dealing with some injuries and woes the past couple the past couple weeks And so we'll see you know how healthy they are the front seven for Dallas is really gonna you know They're gonna have to make They're gonna have to make their presence known especially with the injuries that are up front for Tampa Bay But even then I mean this is something that they've been dealing with for a while Tampa Bay That is and I expect them to get Leonard before net involved I expect the receivers to be involved heavily Brady's probably gonna pass 40 plus times in this game And they're they're just gonna you know try and Have their way and make another run here is what could be Tom Glass here with Tampa So for me yes, the overall lean in this game is that it's playoff Tom Time and I cannot put hard on dollars on the Cowboys until they show me that they can prove it Especially not having a home game here. Is that enough where you want to take the bucks plus two and a half or is that more just a lean for you? I've taken the bucks plus two and a half. I've taken the bucks money line. I know it's changed a little bit But I did what is it currently at here? It's loading 120 Yeah, that's probably is where I got it at Thursday, I think like right after we talked Yeah, and yeah, I feel I feel good about that, especially knowing like what it's going to mean, you know for the bucks to Win here and a lot's been made about you know, Tom Brady's record against the Dallas Cowboys and and things that nature seven to know So I know that's gonna be talked about a lot of the money And a lot of the bets have come on the Tampa Bay side of things which you know Usually I'm seeing fade the public, but this is just kind of one of those spots that feels like We know the outcome before the outcomes been played out, right? For me and we talked about this game on Monday last week And I took the bucks plus three when it was still there with it being a two and a half I've got the cowboy sphere by one point six two and one model and by point two three and another so The other model shows a bit more value in the box here Which is surprising to me because that model is love the Cowboys all year It's I think it's an indication of what you were talking about where the Cowboys Really did struggle down the stretch and that does matter To an extent for sure now the one thing that's positive for them is they get Tyler Beattish back this week Beattish has a high ankle sprain he's her center and He's not gonna be a hundred percent because it's a high ankle sprain Those can take a long time to recover but having his brain out there I think is more valuable than having you know, fully healthy Tyler Beattish like having it just has his brain At center I think is pretty valuable to the Cowboys So I do think that helps a lot. I also did take the under in this game It is not moved at all. So that took it 45 and a half. It was minus one 15 when I took it It's minus one 14 right now. So it is stayed almost exactly the same the entire way and I still feel okay about that my slight concerns are the same ones We discussed on Monday where a the Cowboys secondary is so beat up right now where you could see the bucks Kind of going similar to what they did against Panthers So also the super bang of secondary in that game where they kind of you know flame throw down field and also both these teams Operated at a very fast pace. So those are the two things that concern me in terms of the total We did see a lot of points this weekend. I don't think that was Super surprising honestly, I think that you know a lot of it made a lot of sense where we saw the points come so I'm I still feel okay about the under my conviction It is a little bit lower because there's been no movement in my favor since then but any read for you on 45 and a half Ryan Yeah, I actually kind of like the the over here Yeah, and the reason being is just because like the I mean either one of these teams can force the others hand right and I think that's either gonna lead to just kind of Maybe stop your play which then will lead to shorter fields Which could lead to more scoring so, you know that that's kind of what I like because We know everything's been talked about with this Tampa defense Which has kind of changed over the course of this season as compared to last season But I still feel like the best path for the Cowboys success is through the air not the other run So we'll see if they're able to get CD and Michael and Dalton going here But also, you know, just the opportunistic defense and the way that they play You know if they are able to get sack fumble interception there give them some short fields lead to more points And then we know that Tampa like I said, I just I just have a feeling that Tom's gonna be out there Just kind of slinging it all over so I end the pace for both of these teams is is pretty high from the regular season So I do think that this kind of leans to and over here You know, it wouldn't it wouldn't be surprising as everybody's kind of talked about this You know game going over of the total that we get us kind of sloppy match up and it just ends up being like a 2017 type of finish, but I would lean over for me 2017 with me having three of you fine by me.  I don't care which direction 21 20. I'll take that Okay, let's talk about some props in this game starting off in the Cowboys side the Talk of the town always has been the Cowboys backfield. We've seen a big split here between Tony powered and Zeke Elliott's I'm kind of Operating under the assumption that power gets a bump given it's a high leverage game But it is a tough match up here, you know, they do like Zeke justifiably. He's played well down the stretch What do you see on the Cowboys side in terms of props for tonight? Yeah, I mean, I love Tony Pollard in this matchup I was just gonna look here just to make sure I had the number correct So, yeah, 71 and a half on his rushing and receiving prop, you know, that feels kind of hefty But when you think about like the best path for success with the Cowboys like I think that his you know prop there On the receiving yards, which I believe is that 20 and a half, you know That feels great to get that number if you don't want to take the rushing and receiving But he's at you know, he's had the chance to break off some some runs here I'm you know kind of struggled in the first matchup that they played in earlier this year But I do think this kind of favors him over Zeke Zeke at 50 and a half for just his rushing guards that that feels Kind of high.  Yeah, they've had What is it? Seven games since Zeke came back and here are Pollards rushing plus receiving totals in those seven games 189 61 so that's a miss. So 106 that's a hit. So two and one 62 that's an under 106 over 80 over and then 20 But that was in that that commander's game where he played just 44.6 percent of the snaps So got pulled early So he's four and three to the over in those games if we assume he doesn't get a bump like if he we assume he keeps the same role and I Think I'm not saying it's like a 90% chance he gets a roll bump But I'm saying I think it is more likely than not that his role increases tonight where it has been so Pollard to me is the guy I'm turning to in terms of not only just that market the rushing plus receiving I you mentioned the receiving as well at 20 and a half I think that makes a lot of sense, but also I don't mind aggressive markets with him Like I wish we had alt rushing plus receiving markets. That would be really tempting for him Yeah, I'd be into that but also we'll talk about touchdown bets later. He's plus 190 I think that is a very good number for Tony Pollard So to me, I kind of think it's across the board digging to power props. You highlighted the rushing plus receiving I think that branding a doula on We talked to him on Thursday or Friday. He did not talk about that That's I was looking at that because it's logged in my bets because I have that one personally So Brandon has the power in time touchdown. I have the power rushing plus receiving So we're kind of checking all the boxes here. We're all on board with Pollard. What could go wrong with that? Yeah, one more thing on Pollard Jim receptions for him is at two and a half or at least earlier this week and that was at Plus 116 now again, that was earlier this week I believe it was on Friday when I got at that number It could have changed just a little bit slightly because the any time touchdown prop I got him at 185 and he's up at 190 So I mean things are changing all across the board for it's only probably there but over over two and a half Receptions I just had to had to get action on that his target totals and those games are six Way over. I mean like it. This is target. It's not catches, but six two three five five eight and one like They're getting work in the past. They're giving them work in the passing game I think that that's a very plus one sixteen over two and a half I'm gonna actually check to see if I can get that right now, too Okay, let's let things over actually doing talking to you the past catchers in the Cowboys You want to talk about the bucks? Over two and a half is minus 128 right now. So Wow, okay. Well, yeah, I'm not gonna get a better price at Rhode Island Sport Guarantee that I'm gonna check anyway just to be safe But any more past catching props for you on the Cowboys side, you know flip over the box on the Cowboys side I mean, it's interesting when you see CD lambs over a reception prop currently as it stands right now at plus one sixteen at six and a half so you know Dallas is gonna need to get him involved I mean, he's the most consistent weapon that they have on this team and I get it That might feel like a lofty number, but we've seen time and time again You know these guys that especially like, you know, you have an alpha receiver this he could just be a magnet you know for catches and Listen, I think it's a it's a pretty hefty number But one that I'm willing to get on knowing How how I'm projecting this game to go if it if I'm expecting, you know over points and I'm expecting You know shoot out type of Capabilities here. I'm willing to get on that number there for CD lamb on his on his yardage prop at 75 and a half I mean, that's one that I'd be I'd be willing to take some action to probably not a full unit Maybe a half a unit there. It's minus one 13 I do think Gallops over receiving prop at 35 and a half is interesting too because just from the The big playability for him like he could easily, you know get a 25 yard catch or something like that If he gets two or three catches, he could see himself over that prop as well So so that's kind of where I'm at on the cowboy side right now I did look the powered thing at good old Rhode Island sports book love a good monopoly minus 174 over two and a half. So good The app has been closed. All right, let's move over to the buck side here So we can find something else I can find instead. We saw that offense perk back up in week 17 Looked okay in the limited action in week 18 with no Mike Mike Evans before the starters got pulled any value for you on their side So for Tampa Bay There's well, I should say there's there. I mean, I love all the Tampa Bay players. Let's be honest Let's start off. Let's start it off with Leonard for net because I'm Lenny playoff Lenny Like this is where I think we can get a lot of action over the field on Lenny or I guess over the book I'm Lenny because the field we're all in it together You're looking at his rushing prop at 35 and a half I'm just gonna take that. I just expect him to be on the field. I know we're trying whites there You know, even if it's a 65 35 split like I still feel like he can get there Especially if they're in a position where they're able to kind of control this game Like I think they just gonna churn Lenny and let it let him kind of get going if they are You know kind of just taking them to the woodshed then maybe we see a little bit more Rashad white But this is this is kind of one of those instances, especially with the you know Rashad whites probably and I love him But he's one mistake away from like Leonard for net just being in there the full time Like Brady's not playing around like this is the playoffs now He's got you know, Lenny's earned his stripes with Brady. So I feel like that number is just Just too low. I have to get action on him when we talk about the receiving props Mike Evans and I just want to make sure I have this correct here as we pull up the touchdown scoring pop So Mike Evans at plus 200, which is what I got it at earlier this week like that's just I feel like a slam dunk for me Again, we're talking about the favorite target, which Chris Godwin, you know He's also plus 200 and he's you know got consistent numbers all across this year But just the way that they got him going in the Carolina game Mike Evans That is I would be shocked if they don't try and help have them help find Peter also with Russell gauge Russell gauge has been the red zone leader for this team all year This is where he's made his bread and brother bread and butter in grok's absence Russell gauge anytime touchdown this plus 550 Like we've seen him we've seen Brady look for him time and time again in the red zone It's not you know a K dot and it's and and that right we know what Dallas is gonna do They're gonna make sure that Mike Evans in the red zone is covered. They're gonna make sure that Chris Godwin is covered So Russell cage should probably be able to sneak past somebody In in find a score if we're especially if I'm expecting points to be scored. Absolutely love that. I think that The Lenny one makes a ton of sense again talking about Brandon here on Friday He also had Lenny over 38 and a half rushing yards So you and Brandon very much in the same page and Brandon is I think five and oh so far on the Friday prop So if you're on the same page is him probably a good thing So that's got to feel good about letty and the reason that I like that is Not only the trust factor you mentioned But also it seems like Leonard Fournette's role increased a bit as he got further removed from his injury And honestly, I don't blame them like he played okay in those games They played Rashad white deeper into the week 18 game Fournette played a couple snaps in the first series Then sat the rest of the way and then he tweeted playoff Lenny after the game So, you know the tweet narrative around Leonard Fournette is in line there his rushing plus receiving a 70 and a half I also think that one is interesting too because he does get a ton of work in the passing game I thought a bit about Rashad white under 14 and a half receiving yards, but I wound up talking myself out of it just because You know, there are pretty obvious paths to an over there But I do think that the the four net props in general very enticing I'd probably lean towards the rushing plus receiving just because of how much work he gets But I think regardless buying into an expanded role for Leonard Fournette similar to what we're doing at 20 Pollard I do think that makes a lot of sense Now you talked about uh, my Gavin's two to one. You've got a Russell gauge plus 550 Who else talked a bit about 20 power to plus 190 Four in any time touchdown There was one more I wanted to ask you about one that I saw that was enticing is Kate Otten He is six to one to score a touchdown I can't touch a Kate Otten yardage prop because he doesn't get yardage I don't know if it's like not if it's like his contract. He's not allowed to get more than like 17 yards in a game um, but from a touchdown perspective, you're getting a guy who In the past two games he played with Cameron Brayte, which was weeks 16 and 17 In those games otten had an 84 87 snap rates So even when Brayte being active both those games Otten basically didn't lead the field. He had seven and six targets in those two games Did literally nothing with it, which is why again, I will not touch yardage props But touchdown props six to one for a guy With an 80 snap rates I feel like that's kind of a turn down. So I think to me In the non power department I would lean towards Kate otten at six to one is being my favorite Any thoughts for you on Kate otten or any other touchdown bets you like? Yeah, Kate. Kate otten is is interesting. Um, I think I think you know any any of these any of these guys It's it's fun to have you know a little bit of action on them Um, because we know what they want to do 20 You know if they're at the 20 yard line even at the 10 yard line, you know, I think that they're going to be willing to pass Um on second and third down. So any of these guys that is is fun to have action on Um, I do think that there is merit to taking Brayte at 15 to one to score a touchdown I mean if they're on the one like we've seen we've seen him do this before just sneak it in like he'll he'll take it himself Uh at 15 to one for a quarterback prop, you know, that's pretty incredible So, uh, just to have action on that. I think it's a fun one too. Yeah, he had a rushing touchdown against Carolina, I think yeah, uh in that game. He had a sneak touchdown in that one. Um, so It probably wouldn't pull a hunt Lee where he You know gets it popped out of his hands Uh, the Trevor Lawrence when I think it was on a two-point conversion where you're just like a boop Like but he's like six foot six So you can kind of like just stretch arms strong, you know yourself across the goal line But I think Brady Jordan and space June. Yeah, that's right. You know You're in loony tune land man do it. You can do whatever you want Kind of dream bigger. Uh, but yeah, I think that the Brady one is interesting too, but It's a fun game. Um, it's it's an interesting game for sure. Kind of like you said, I don't really know what to think overall I'm hoping we get, um A lower scoring game hoping we get the the bucks to at least keep this game closed and keeping it a field goal But we'll see how things play out for it's not any final thoughts for you ride before we close up shop for today No, this is just you know, this is fun fun time guys. We get the island game So make sure you guys are being smart with your action But definitely get a lot of action on that gear up for next weekend divisional round We're gonna have a ton of fun matchups as well then too Can't wait to dissect those games with you Jim. That'll be a fun one. But yeah, just uh, you know Have fun if you guys are betting Dallas because uh, everybody is on Tampa So I know that Vegas is uh rooting hard for you. Dallas betters out there Ah Yeah, just glad I'm like I thought I thought for the longest time because you knew this matchup was coming I thought for the longest time they'd be betting Dallas and just be nervous the whole week Like I could lose tonight. You know the sleepy tom narrative is in effect It's a it's a prime time game for tom brady after his bedtime. So, you know that that's happening But like, you know, I just feel a little bit carefree if I lose I lose I'm much less nervous than I would have been had I bet the one up any of the cowboys So at least we got that going for us regardless. Hopefully we can finish out Well, okay, we can high note because it has been a blast so far That is all that we have here for today on covering the spread I will give my first look into The divisional round tomorrow on the show We'll also talk to you brandy gadoola to get his thoughts on some pga action For this week to get that and the rest of our podcast search for covering the spread Wherever you get your podcast make sure you hit subscribe because markets do move We want to make sure you get these as soon as they're posting also Check us out over on the fan dual youtube page ryan. I appreciate you once again As always swinging by for today. Good luck to you tonight. I'll talk to you once again on thursday Sounds good. Jim looking forward to it. That is ryan williams check him out on twitter at ryan alexander underscore w i am on twitter at jim sonnis j i m s a n n e s looking forward to talking to you all once again tomorrow enjoy monday night Football this has been covering the spread right here on the fan dual podcast network