what's your mouth my name is gone I'm perfect segue hey welcome back to our stupid or actually it's up Corbin I'm Rick and you false it is the job Twitter choose the content bull robs and free for all if there ever a day to wear all of my shallow con apparel it would be today and if I had mine that I was looking for yesterday I would have wanted as well but I couldn't get it to me in time but it is romance month and the one film that we could not get out of romance month without watching or we would have been murdered at the stake yeah would have been via Zara which we're doing movie review sorry I forgot to introduce oh yeah we're doing movie review you saw the title yeah and a liar here and this was when the minute we said we're doing a romance month yeah this I mean obviously we knew a shabu-kan film and all that kind of stuff but specifically via Zara I mean that's been recommended for a long time long time when whenever we said we're doing a romance month they're like you better get the views are but it's a 2004 Hindi language film directed by Yash Chopra and starring just a little unknown guy named sir Shahrukh Khan yep and pretty zinta and Ronnie McCurgee yeah and a whole school of folk I'm a talk about John and Manoj Bajpayee and Anup Anup Anup Kerr just a Kerr right where Anupum Kerr Kerr yeah wait where did we see Tom Altar he had like one line who was he I'm trying to remember this would technically be the first time alter thing we've ever seen yeah but like who was he he shows up if I'm not mistaken the scene he may have had two lines it's toward that's three-quarters of the way in when Ronnie shows up to the attorney office and he's talking to her before she meets up with the lawyer yeah thank you Anup Anupum Kerr she's talking to him because he works in his office okay but you wouldn't necessarily have recognized him because he's only in profile it's a two-shot with Ronnie and that's all you get is a couple of lines that would technically be our first to think of technically film of his yeah because all I've heard is like anytime we make fun of white actors for being terrible they're like you got to watch him because he's like the best white actor and I will say he didn't see I didn't even notice anyway that's a good sign but it will obviously be a hundred percent for the view anytime we've seen a shovel con film especially an iconic one you've all seen a film yeah so if you haven't watched it we saw it on Amazon you can go watch it it's a three-hour film like all the films in from 1992 or yeah that's essentially over three hours but Rick your initial spoiler thoughts I guess yeah well I'm not spoiler at the beginning really I don't have much in the paragraph but this is our 12th movie of the year our 136th Hindi 219th all-time and even though we've seen DDLJ Khabi Kushi Khabi Gam Kuch Kuch Hota Hai Dev Das Swadesh and my name is Kanda name a few we were told we've yet to truly see why SRK is considered the king of romance in fact when Andrani and I sat down to watch this movie she said now you are about to see why SRK is SRK I went into this film with a certain expectation based on past experiences with older SRK films this movie didn't meet that expectation it surpassed it by 786 miles you like that 786 you like that thank you so much I have so many exemplary things to say about this movie that a single paragraph would be an insult from SRK to predizinta to Rani McCurgy to Big B to Keran Ker to Boman Irani to Anupam Ker to Manoj Bajpayee to the direction and scorn costuming this is not only my favorite SRK film thus far but one of my favorite films we've ever seen in one of my favorite love stories ever captured on film holy shit I'm in let me get a boot for you here where's that Bollywood bootlicker I was it was way better than I was expecting on so many levels so I don't know what you thought of it but that was my thoughts and I have a lot I can say as to why I like I also I really enjoyed this film and it was different because I went into the exact expectation of DDOJ K3G me too and then that's what I was expecting that's what I had set my like my fine artistry independent film and film festival hat to the side and just went I'm gonna have a really fun time and I'll probably be touched a couple times yeah yeah yeah so that's what I was expecting I was expecting you know the cheetah cheetah who is a cheetah moments and you play good basketball but they just they hardly ever came those moments there was very few of very very very few of those types of moments in this film and it was I'd say one of Shahrukh Khan's most grounded better performances how many babe how many times that I talk about not I just consistently was like Ronnie's so grounded Katie's so grounded SRK is so grounded this whole just everybody but I was so taken by it made me I was like yes I said at one point and Ronnie I said see I like was talking to SRK on the thing I'm like SRK bro flex the fast the spionatic muscles like this now your fans love you doing this kind of stuff it doesn't have to be the rompy-compy stuff so anyway yeah it was it was it was a it was a wonderful surprise I mean it still had that big Bollywood feel to it but it wasn't it didn't have like the I don't know what element I'm but that over the top I mean it there were melodramatic over the top moments and stuff like that but I'm talking like in the acting right where it just isn't believable anymore and it's just silly it's just silly they just didn't have that yeah it was like a completely believable and it was a wonderful love story I mean you knew where it was gonna go I equate SRK films especially this era 90s early 2000s similar to rom-com it's like but it's not a rom-com no but it's in that same genre I know what's gonna happen in a rom-com and it's I don't really go in for like to to be like impressed like I do with like a Nolan film or not at all never but I go in and I'm like this is I'm gonna enjoy this right and I'm gonna enjoy the ride and you do and you enjoy the hell out of this ride it's a three-hour film but what that Bollywood does maybe not Bollywood is exclusively but Indian films in general they make a three-hour film not feel like three hours because they put 15 songs in it and so every 15 minutes you have a nice break and you're like this is fun yep and so you don't care about the three hours as opposed to I mean when they don't do it like in push-pot and it's not enough song right not enough stuff happening right so just drags this one for a three-hour 12 minute film it didn't drag for me not at all man I'm interested when we get into the plot points and story cuz we'll talk technical stuff I have a question for you about how many things you saw coming versus how many you didn't I saw you always see I saw everything every little thing okay I saw one thing for sure it happened it wasn't the knock on it although I was trying to figure out the beginning I was like okay when are we gonna find out that she was shot and then as it went on I'm like okay that was clearly just something that was happening is basically like she got shot exactly yeah I was waiting I was like when does she get shot was he framed for the for the murder what was happening that was the thing that was that was throw out let's go into the acting like we do when we jump off three to things yeah this we already said it this might be I don't know if it's my name is Khan is still a great performance of his and it's so different from everything else he's ever done and then what else have we seen him in my favorite dj yeah my favorites of his that I've enjoyed the most were I know you won't agree you didn't like dev doc yeah swadesh oh yeah that would my name is Khan yeah it probably between my name is Khan swadesh and in this one yeah I'd say as far as this most grounded yeah I'd say swadesh is probably even more grounded just because it's not a big body would feel to the film it's more of like a natural and then my name is Khan is just a so such a different style of role for for him but this man it was so surprising because it's I mean he showed the grounded moments in the other ones but only partial part of the time a lot of the times that required him and it's what's so endearing of something like DDLJ when it's campy ridiculous silly yeah yeah yeah and you enjoy that right but obviously this is just it kind of caught me off guard yes the entire thing Ronnie didn't catch my off guard I expected that from Ronnie she's a great actress yeah bottom line and she's always this good in everything we've seen her yep and so I loved her it was still sad that she didn't get show her con in the end I don't know if we're ever gonna see a film where they get together I said good I said that right as soon like right when they're at the border and it's for the end I'm like I still want to see Ronnie be with SRK I know she's not a love interest she's the hero of the film but man I want to see her I think she deserves it yeah she's done enough already she deserves to get her economy and the other thing aside from just she doesn't cease to impress as an as a stellar actress I just over and over again we was saying to and Ronnie she's so beautiful she's her her eyes her skin and I said to our said it is she included in conversations when they talk about some of the most beautiful like a shawar is always talked about I think Ronnie McCurgee is not only one of the best actresses that I've ever seen in Indian cinema but she's one of the most cinematically such a beautiful woman and this is one of the first things we we've seen another pretty one but I think she's incredible she has this unique almost a young Drew Barrymore style of face oh yeah I think she has that style of face it's like very lovable yeah very like innocent yeah and then I thought she did a phenomenal job her chemistry with what what have we seen her in they'll say we say and it was that it we've seen her in a bunch of trailers and we've had a lot of a stupid baby say like we've seen her and more oh that's right yeah they'll shut that that's right that's right don't shut that but yeah she she had great chemistry with show con and the believability factor luxury sorry she was in Lakshya as well she oh that's right she was that's right I don't do her thing right now she the believability factor for the entire cast but especially these threes we we've just talked about I I believe every moment that they were on screen I there was one moment where Ronnie was talking to SRK in the prison and she's pleading with him and I said to him Johnny I said she just doesn't cease to she never there's there was no indicating everything is genuine there's nothing that's being done for affectation I just everybody in this I felt was like in the moment and presenting us real people that I cared about very much and no shock I'm a good and I was sad when he was like left and then I realized he wasn't in the rest of the film yeah I was hoping those characters would come back yeah I wanted them to interact I thought both of the mom and in I'm a type box on the relationship with pretty yeah it was beautiful me too I thought they had great obviously Bigby's character was so quirky and unique and yeah I love their song I did like I'm gonna marry you for the next seven times and she's like no you're not you're gonna I out loud when she came over and picked up the stuff and went oh dad totally dissed him yeah so I thought their relationship was absolutely fantastic it's it's it's wonderful there and it was it was still a big Bollywood film and so everything kind of he came to the realization that he was being discriminatory to women very fast yeah now I'm gonna make a school yeah so there's all this stuff yeah but in these style films that I know what you're going into I'm like I don't care about that not like I know this is gonna be kind of campy almost at times yeah I don't care I go in for the entertainment but I think that goes to a yash Chopra did yeah this is our second yash Chopra is that our second or is our third DDL J was his his right wait was it DDL J Karen Johar no K3G was Karen Johar okay 3g that's right and but the anyways it was one of our first ones buddy I know he's like a legendary director of course and all that but I thought he did a phenomenal job at getting the big feel of this early 2000s Bollywood film but also not making it campy similar to the other one no I played a really fine line with the score in terms of like the melodrama yeah so it wasn't as melodrama as like K3G was not at all but it was and it was almost endearing at this point because the because the melodrama came more at the end and it was because the actors were so grounded yeah when you have that music accompanied by over the top then it doesn't work yeah because everybody was so grounded and so many cinematic choices there were so many beautiful lighting choices especially when Ronnie and SRK are in the cell together there's some lighting shots almost like a play the way this was lit in so many instances and then when they were in the courtroom there was a moment I pointed out with a drawing she said that's such a beautiful room they've used it's so grand and I said yeah notice there was a shot right as she said it where they used it looks I'm sure it was a crane to take you up as they're showing the room from behind the judge so that you get not just the expanse from a visual field straight on in a static but to give you the flow of movement that you feel because you actually feel in a room that size yeah you feel the stretch of the room and so to give you that sense of ambiance there's that camera move and he that was done many times to give you a sense of the feel of the rooms that they were in extremely well done yeah I did a really good job at kind of catering that style of what people expected in the late 90s to early 2000s yeah from a Bollywood film with Shah Rukh Khan yeah the big they and you'd goers love the melodrama they love the over-the-top yes but I thought he did a good job of kind of blending a little bit of that with a lot of like more natural acting and shots and score and I thought so I thought he did a really really good job and the other actors so so many faces popped up I had forgotten Manoj was in it so he popped up and I went that's Manoj oh yeah of course he's and then we had well the three people that popped up that surprised me when I saw them first come up were Karen Kair yeah which we've we've seen many and is always good yeah always solid the scene that she has with SRK this goes that this is a testament as well to the writing it would have been really easy to make people villainous in some way like the mom for example could have been why are you doing this to my family why are you doing this to my daughter and when he says you're like all the mothers that scene you're she's like you're the son's here and he's like well you're the mother's there and you could see she was she was torn on the one hand she doesn't want her husband to die she doesn't want her family ruined but at the same time she recognizes this is a really genuinely good guy that her daughter's in love with and I love the fact that it kept a level of complexity with the characters it's a testament to the writing I also felt like while there was some things that were predictable it it wasn't easy choices I felt that were made I thought that everything that they did were in alignment and congruent with a really solid story and she's probably the character that I sometimes had the most problem with but that's kind of just common for me now to not like the moms and Indians I clearly just like why are you so over the top clearly just something I need to accept because it's a common theme throughout especially Bollywood films for the moms to be this big stick over the top you know dramatic she wasn't always that and I do agree that I did like her character that wasn't just a you will you will get married how are you doing this to my family right I didn't enjoy that yeah aspect to it and she didn't all she wasn't always extremely over the top and two other faces that I want to no longer call him the guy from three idiots because we've seen him so much I was such a good actor wait a bowman I keep on Ronnie it yeah okay yeah but I keep calling me sigh Cyrus and I don't think that's his name no it's Bowman and Ronnie what's the name of the character though oh in this no three idiots oh I don't remember I don't was a headmaster that's all I know him as is the headmaster from that but yeah I saw him when he showed up great to see him as well as I learned something new you may have already known this of course stupid babies know this but on a pump care care first of all we've seen him in a million things as well as he has quite a few American films that he's been in yeah but look at the last names of Anupam and Kiran the mom oh they actually married yep oh really their husband and wife oh that's cute yeah I didn't know that that's cute I like that but they were all great the score was phenomenal yeah we weren't able we've reacted to a few songs and they're all I think on patreon because that's why RF yeah you're not gonna see that yeah but it's there like I said that what what Indian films do well in their old three-hour films about every 15 minutes from the opening of the film to the very end you're gonna have a song about every 15-20 minutes yeah to kind of keep you engaged and like this is this is a great entertain this is but didn't you recognize I was so glad we had words for the songs because sometimes we'll get movies and there's no words for the songs most of the songs weren't item numbers they were carrying the story along and I loved that about this movie and I loved every song yeah there when when they were kind of spending a day together and then when he went to with the SRK to meet his family and their their songs and then towards the very end I mean I loved it when the minute the Punjabi started dancing they didn't need to even say anything I'm like there's the Punjabi yeah party absolutely yeah so I thought all the songs by the composer Sanjeev Kohli and Madan Mohan it was also Lada as well yeah this was a wonderful obviously we didn't do it on purpose obviously we gonna watch this regardless but the fact that we got to hear Lada and one of her most probably famous films yeah I was wonderful to hear her voice two other technical shoutouts for sure that were standouts I was very impressed with the smallness and the simplicity of the makeup and the aging process that they did I felt like makeup aged SRK and pre-D really well they that's very hard to do it can usually look really bad and you just forgive it because it's so so hard to do and while well the CGI on the bus going down the thing was not good I I love the times especially at the end when spoilers so soon you've all seen this when she came to the courtroom and they're reunited the when he sees her and they transition to the way they used to look about 20 times yeah yeah and the first time they do it when he's in the jail cell and he he's young SRK holding on to the window and then it transitions to him in the prison that was that was pretty clean that was pretty clean now I have a question I know the answer to did you cry no no we're close did you like a baby I cried a couple times so did my life we were just we were there like this and I turned her at one time I said if I I have a lump in my throat if I wanted to I could just be bawling right now because here's when I called obviously I knew not a film Ronnie I knew that Ronnie was gonna go find Preeti and bring her back and I said I said I can't wait to see SRK's face and what the music's gonna be when she comes walking into the courtroom I knew that was gonna happen yeah but I cared about these characters so much and I cared about Ronnie McCurgy's character getting this to happen and winning this case but especially this love story my favorite thing about the story is that it's a love story that's based on what you're willing to do to lay down your life for the other person versus fighting the world to be together it was I'm willing to give up my world for the other person which is really the essence of true love it's not it's it's not about you know greater love has no one than this than to lay down your life for somebody else and the fact that they both did that and he didn't even know she did so when they got reunited and they did that flashback they're seeing each other now in the present but what they're seeing is the way they saw each other at first that whole song the minute they saw each other and through that whole song that's when I was crying in the courtroom yep in the courtroom I got emotional I almost started to cry when I saw that she was taking care of his mom and dad's place and that she'd been there the whole time but I cried there and then I cried at the very very end when they were at the border and they leave and I think they were at the waga border they were definitely we've been there the minute they saw it but we have been there but yeah I probably for the last 15 20 minutes of the movie I was in Johnny and I both were just really oh absolutely 100% like I said I enjoyed you know oh you know so the first time was the courtroom you know what had happened the second time they're standing at the border and Ronnie pulls she the minute she pulled out the little silver can't contain her I looked at it Johnny I went oh no cuz I knew he was gonna take it and he was gonna put it on her and I thought that's what that that got me to even right now I'm getting emotional thinking about it so yeah I cried like a baby no I did think that I've never seen SRK look better than you when he was dirty and bearded and hair in the jail it's so great he popped I'm like oh you look good SRK started we started watching it last night right so we got about a halfway through and it was getting really late didn't want to get sleepy so this morning right as I'm about to make in Johnny her morning cha and get her you know she's still laying a bed and she hasn't really she's awake but she hasn't looked around watching about five minutes of the movie and then the song where Preeti is she can't which I thought was brilliant the way they depicted the song when Preeti she can't stop thinking about him and he's appearing everywhere she looks yeah I thought that was a great way to just say she can't get him out of her mind the minute he starts to sing no joke and Johnny's lying there the minute he starts to sing she goes you may not know this but that was her young girl crush was SRK so it was fun watching her crushing on SRK yeah I asked her said if you made a SRK you're gonna be a little gobsmacked she went oh my yeah and I could I could obviously I could see why obviously it's a perfect film for romance month oh obviously it's it's it's it's the essence of romance and I think we already got why SRK was like the romance king but this one is on another level of like just all there's no there's no Tom Fullery going around there's no nothing high school we're high school students now and this is mature this is like and you get some of that in like the the second half of hey right and that surprised us you get some of the love in K3G and obviously DDLJ but this and this is your favorite SRK film yeah this is as much as as much as I love Swadesh Dev Das and my name is Khan the there are too many things about this did I mention costuming you haven't yet no big big gorgeous costuming that's what I meant in my opening paragraph that it would be an insult to divulge whatever I think about this in a paragraph because I could talk for 15 minutes easy just about how gorgeous costuming and jewelry was in this film but yeah this is for me and obviously I'm fresh off the film we'll see over time what happens but as much as I love Dev Das my name is Khan and Swadesh because I love those films this one because of how grounded SRK is because of how unilaterally great the cast is the technical greatness the greatness of the writing and the score on the costuming and then that irreplaceable moral to the story of the fact that this is a love story of people who sacrifice everything in order not not so that they can get what they want but for the they both did what they did for the benefit of the other person he gave up his life so she could be happy and then she gave up her life for his family yeah yeah and I love about shower cons films they're very rewatchable I guess it's similar to like a rom-com rom-coms are obviously very what you just watch them for the feeling you watch them so you can be happy you know everybody's gonna get together in the end yeah I'd say that about all of all of I mean at least it's especially the the big Bollywood ones like DDLJ K3G, Kuchu Jodahai this one ones that are the big over the not over the top all of them but the big numbers you can do like if it's on you're like I'm gonna I'm gonna watch this I'm gonna enjoy this absolutely I can do that with all of those maybe not my name is my name is kind of even though might be the better performance it's not as that's one to enjoy the technical yeah it's not as going on watchable as some of these other ones correct you could sit and enjoy this song oh yeah I love this song yeah my name is Conn requires you to kind of focus on what is occurring whereas this one you can do that but you can also just sit back and just enjoy being in the film and there's there the more we watch of him and this one my wife is absolutely right if someone were to I wouldn't want this to be their first SRK movie I'd want them to see a few other ones yeah then and I would say the exact same thing I would say if you want to know why SRK is SRK and she even asked me at one point she said do you find SRK to be a very attractive actor like because he's such a superstar and I said it's interesting not in the way like people look at Rithik and they're like oh my goodness you immediately see how beautiful the man is there is a quality to SRK that transcends physical he's a very handsome man yeah but there's a rough handsome he's like he's almost like an every man he's that he's and and I really believe in this film captures it because what we've seen in his speeches what we know about his personal life that the man himself SRK is a good man and these kind of roles you can't be this role as well as he is unless you're sharing something of yourself that's actually it's like Tom Hanks yeah there's a quality to Tom Hanks that makes his characters so kind and so lovable because Tom Hanks the man is a kind and lovable man yeah and that's why it's more than just the arm spreading thing now it's even there's a charm about him and a kindness about who he is that makes you want to root for him and makes you fall in love with him so I yeah sold absolutely well thank you so much for being patient yeah really so and I'm sure and I know why I know for a fact there's many more Shahrukh Khan films that we need to get to yeah but what should be our next Shahrukh Khan and pretty Zinta and Ronnie McCurgy is is there one that's worthy of a watch that Ronnie and SRK actually get together in the end my wife tells me there are is it worthy that she's nodding back there come on I gotta I gotta see Ronnie win in the end with SRK yeah I just like gotta see what let us know what the next Shahrukh Khan film should be and the next romance film maybe they intertwine down below


Hello everyone, this is financial author Amit Dan of amitdan.com. On this channel you'll find financial travel and more videos just like the one you're watching right now. If you like what you see, please give me a thumbs up and consider subscribing. Canada's Best Great Curse Hello everyone, this is financial author Amit Dan of amitdan.com. Today I'll talk about Canada's Best Great Curse by Red Supermarket. Red Supermarket is an online comparison tool website that compares mortgages, credit cards and many others and they have just come up with their annual ranking of Best Great Curse in Canada and today I'll talk about that. I'm expecting this video about 3-4 minutes long. Red Supermarket has also published another Best Ratings for Canada's Best Finance and Investment Products and I'll do a separate video on that. So for today let's start with Canada's Best Great Curse and I'll provide you the names of these great curses on the screen and also I'll give you the Red Supermarket website link on the screen. Canada's Best Great Curse are chosen for various categories and I'll give you some of the most popular categories and some of the curses came out on top of the list for these categories. Best Rewards Card with Fee Scotia Momentum Visa Infinite Best Rewards Card with No Fee Simply Cash from American Express Best Great Card for Carrying a Balance MB&A True Line Mastercard Best Great Card for Balance Transfers MB&A Platinum Plus Mastercard Fan Favorite for Best Great Card Tangerine Moneyback Great Card Best Great Card for Students BMO SPC Cashback Mastercard Best Great Card with Travel Parks Scotia Bank American Express Gold Great Card Best Great Card for Groceries Business Choice Financial Mastercard Best Gas Rewards Great Card with No Fee Shell Irma's Mastercard from BMO Before I end this video I'd like to mention that do not pick your great cards based on any best great card list or anything always do your research and find the best great cards that suits your needs. My channel has lots of great card review and information and all these videos are unbiased and non-affiliated and once you have your research and you know that this is the great card that will meet your requirements and needs then go for that great card. Thank you for watching if you like what you see please give it a thumbs up and consider subscribing and I'll see you shortly bye


The topic we are going to discuss today is making ethical decisions and taking actions. This is very much evident that during the course of therapy and practice, when colleagues, supervisors or students engage themselves in a questionable act that could cause harm and lower the public trust, mental health professionals has a proactive role to play. There are many such situations in which distress is created because of the different actions which are being taken by either the students or by any scholar or by any supervisee or colleague. This is a very important ethical duty that when it is identified that an unethical act has taken place by a colleague or student that could cause harm to someone, so one has to identify that harm and one has to take a proactive role and talk about that. The reason is that if we do not highlight any unethical practice, we will not talk about it, so that will also become the part of the record and we will be able to see it again and again as a practice which is incorrect and which is morally and ethically wrong. Now, it's important to understand that this process is not that easy and whenever someone is going to talk about any such unrest in terms of publication, in terms of therapy, that something unethical has been done, there are many stressful situations that they have to face. Therapists working with diverse clients whose value contradicts with those in Western civilization or either in Eastern civilizations, they require specialized knowledge. This is a very important thing to understand that every culture has its own norms, it has some strengths, it has some weaknesses and when any individual from that specific culture comes for their therapeutic assessment or comes to take guidance or counseling for their therapy, then the therapist there will probably be mistaken in understanding the individual's ethnic background, his cultural problems, his practices, his norms, and he would be mistaken in understanding them and he will not be able to tell them any proper course of action. NAP and Wend Creek in 2007 proposed a soft universalistic approach. Now, what is the universalistic approach? It is very important to understand that when we talk about different cultures, we talk about different societies, we talk about different religions. There must be some commonality between all of them. Of course, we can see the differences because if there are no differences, then that culture, that society, that religion cannot be separated. But there must be something which is commonly embedded in all of them. So when we look closely, we can get to see that there is no such culture which teaches us that we should treat others badly. There is no such culture which teaches us that we should disrespect others, that we should not love them, that we should not respect them. I understand that they may be different in connotation, in the practices, in the way we behave, but of course the basic ethics and values of all religions and cultures are more or less the same. Without the individual variation, if we talk about their core and trucks, then we are trying to teach them something good. So the soft universalistic approach is that that we have to see the moral and ethical value of all the things which are being practiced in that specific culture, religion or society and we have to ignore the other specific part of the religion we have seen in terms of the practice. It is not necessary to see how they are practicing that religion but if there is goodness in its essence, if there is righteous behaviour in its essence, then we should focus on it. So now we understand that most of the cultures share the basic values, but of course they are not expressed in the same way. Therapists need to assess this wider perspective by focusing on principal ethics. The most important thing is to focus on whether we have to give people respect, whether we have to give people compassion, rather than what will be the domain of it, how it will be given. Then therapists should not try to become more proficient culturally, but also try to make effort to reflect on the impact of their own beliefs and practices when dealing with culturally diverse clients. It is not necessary that another individual's culture is adapted to 100% and then therapists understand it and give it therapy. Rather, your cultural beliefs and your cultural thoughts and norms use the ethically embedded goodness to deal with culturally diverse clients so that from their personality, from their problems, from their lifestyle and story, you can only pick that component which you can ethically deal with. The rest of the things will be unethical to deal with on a one-to-one basis. For example, a big challenge for local therapists involving working with the immigrants from Afghanistan do not know their language well to communicate or have certain stereotypes and prejudices against them. Now if we talk about even in Pakistan, when we talk about therapy, when there are Afghan immigrants and they have the language problem, they know the language and therapists only know Urdu or Punjabi. So it is not possible to communicate with them. So this could be one of the very, very pertinent barriers which culturally diverse individuals can face. Along with this, if they use a translator or any other mechanism, they could discuss this about them or they could have a specific kind of stereotypes about them. That the Afghans have a special stereotype in their mind and deal with that client to keep that stereotype in mind. So this could be a very unethical practice. Knowing, understanding and creating sensitivity to world's view different from world's own is a critical step towards making sound decisions about therapy directions. We cannot face our personal point of view. We have a universal point of view in the world which supports ethics which supports goodness which supports well-being. We have to keep that in mind and settle our goals. We cannot be judgmental. We cannot be segregated. We cannot be biased about any kind of client who comes to us in a therapeutic second. Rather, we have to take him as a diverse population and give him counselling and treatment through ethically embedded principles.


You're listening to Trash Talk on WTBU, the beat of Boston University. Trash Talk is an entertainment radio show on Boston University's student run station. The hosts use social media apps, including TikTok, to find content to discuss. But the possible TikTok ban could affect where they get their talking points from. If TikTok were to be modified, we would not be able to use that and curate our show outlines as we have been doing. And since those show outlines have been successful, I'm not sure what that would mean for the future of our show. Trash Talk host Andrew DiBiazzo says people should use TikTok with caution, just like they should with Instagram and Facebook instead of a widespread outlaw of the app. The government is treating it as a different issue or a more serious issue because it deals with a lot of younger people. But I also think that younger people should just treat this as any other political decision and just consider it for themselves. Lawmakers created a bill that would ban TikTok in America within six months due to national security concerns. Another Trash Talk host, Kenala Fitt, says the government's paranoia stems from the app's Chinese-based parent company. The concern wouldn't be as big of an issue if it wasn't like a foreign government because Facebook and Instagram use a lot of the same data privacy and the algorithms and stuff are very similar to that of TikToks. CBS News says the Senate must vote on the TikTok bill before it gets passed to President Biden who said he would sign it. Reporting for BUTV News, I'm Sophia Falbo.


Nothing is impossible when you put your hope in God. I'm standing here in the midst of a miracle in the making. I'm about to give you a tour of the future home of EncounterTV Studios, Round Rock, Texas. Now many of you have been giving toward this project, so I thought now would be a great time to give you an update. Now here's the challenge. You're going to have to see through the eyes of faith because as I said, this is a construction zone, but I do want to give you an update so that you can see the process and you can see what's coming. Right now I'm standing in this room, which is really the front entry. So when you come visit the studio, there will be a door right here. It's going to be a glass door, I believe. And then this opens up into the lobby area, the entrance area, where you'll be welcomed with our beautiful Dove logo. Of course, everything we do here is done with excellence, the culture of heaven. And as we move through to the main area, you're going to notice this big box that's in the way. Now this is actually a temporary studio location because we need a place to film while construction is ongoing. So this is actually the place where we've been filming Word and Spirit. We've been live streaming, viral revival. We've been creating much of the content right in there. It's a temporary studio location while we work to build out the main facility. So this right here will be wide open once this box is gone. So this box will be out of the way and it will just be filled with chairs and tables, a place for you to fellowship, rest and prepare before the service. Speaking of preparing for the service and the studio tapings that we'll be doing here, you can come in as a live studio audience. I believe they're telling me as of right now when we're looking to increase this, we know that we will have at least a seating capacity for a couple hundred people live in studio. Now here is where the coffee bar will be. And as I said, this is something that we're doing for you, the people who visit the studio so you have refreshments, a place to sit so you're not just waiting in line in the heat or in the cold before the taping begins so that we can really do a good job of hosting you, our supporters, our viewers, our friends, our partners. Moving through here now, we are going to be looking at part of the main entry as well. So this continues. Now this right here is actually going to be a very special portion of the lobby area. We're looking to build a small version, a miniature revival history museum. Many of you know that in phase two and three, we actually expand to include the revival history museum. For more information on that, you can check the website. But really this is going to be the beta version if you will. So the lobby will include some elements of revival history, pictures of God's generals, maybe some information about revivals past and so forth. And again, you can check the David Hernandez Ministries website for a little bit more information on that. Now this right here will be the main control room. And again, look through the eyes of faith. This is where Mr. Timothy Lay and his crew will direct productions that are live and also direct productions that are not live. So there will be computers and screens and that actually is a window right there that looks out into the studio area. So you can see out, but you can't see in. So this way you don't see Tim and the crew in the background while we're taping. Again, there's that word taping. I don't know how many times I'm going to use that, but when I say taping, just know everything's digital. I just use tape because I've been programmed to use that word. This is the data center. This right here is the data center. This is going to be a room filled with hard drives and tech so that we can back up many of the files. In fact, all of the video files for all of the teachings that we release. We know that these days censorship is a very real threat and it's very possible that ministries like ours become de-platformed in the future. So what we've done is we've begun to back up every episode of Word and Spirit, every episode of Vival, Revival, every video we put out, every worship clip, every highlight, everything that you see is backed up onto a hard drive and onto the cloud. And that's a lot of data that we use. So this room will actually be filled just with many, many, many hard drives and this room, of course, will be expanded in phase two and three, but just so that we have a place to put all of that content for now, we're going to be using this room as the data center and, of course, all of those videos will be housed here securely, safely on the hardware as well as on the cloud. Let's continue on to the other rooms. This right here will be the men's restroom and this, of course, is something that's needed. You need restrooms wherever you have people gathered in public. Now, this room right here will actually be our shipping center. So if you've ever partnered with our ministry or ordered a product from our ministry, you know that everything comes packaged with excellence, really high quality. We actually oversee that in-house. All of the packaging is in-house. In fact, all of our clothing now is all made in-house and so this will be the shipping center where partner gifts and books and clothing are all sent out. So this room is going to be filled with shipping material, product, and so forth. Right across the way is the women's restroom and then coming down this hall, this is the back area. This is where employees of David Hernandez Ministries and EncounterTV are working and this right here in front of me is the green room. The green room is the place where we host our guests. So, like when I have friends on the program or friends on the live stream, I fly them in, we tape a few programs. They need a place, too, to prepare before they go on to the set and that's the purpose of a green room. Just on the other side of the green room, we have the conference room. This is where we'll have staff meetings to make sure everything is operating in an orderly fashion, that everything's being done with efficiency. This right here is an office and this right here is an open space concept office. Now, this open space office is going to be the heart of EncounterTV editing. Mr. Tim Leigh and his team will work here all throughout the week to produce content. You know, we produce a lot of content. So, there will be desks and computers and all of our editors will be able to work from here and just across the way in this other room, which is about the same size, we have another open concept office and this is for administration, events, finance, and so forth and actually because of the temporary wall here, you can't really see the full size of this open space office but it's actually bigger than it looks. Again, there is a temporary wall there. So, you know that our ministry has a saying, we spread the gospel of Jesus Christ in the power of the Holy Spirit through events and media. Well, this is the room where they're going to manage the events and the administration and the finance that it takes to do that and this room that you just saw right in front of me here will be where they manage the media. So, events and media, all the staff working together under one roof to promote synergy and efficiency and better communication. This really will be not just a tech center, not just a media center. This is going to be a revival center. Just a couple of weeks ago, we invited partners and friends of the ministry to actually come on to the location of this construction site and they walked through this building and began to lay hands on the building. They prayed with oil. They planted scriptures. They said in the prophetic words, why? Because we want this to be a place where we dig a well of the manifested presence of the Holy Spirit. We want this building to be saturated in the manifested power of the Holy Spirit. This is more than just a media center. This is more than just a ministry headquarters. This is more than just a studio. This is expansion for the kingdom of heaven. This is a piece of heaven on earth. We are claiming this territory for the name of Jesus. And as we claim this territory for the name of Jesus, we're using this location to touch the nations of the world in a more impactful way than ever before. This will exponentially increase our ministry reach. That's why we're doing what we do. And it's more than just numbers. Numbers represent people. People represent souls. So that's why we want to expand to bigger numbers than ever before. Now, right here is the entryway. When you come in person to the studio, after you've had your coffee, after you've relaxed for a little bit, you'll begin to line up here. And it's here that you begin to enter into the place where the nations of the world will be touched. From this location, the gospel will be preached. From this location, the power of God will be emitted over the signals, over the internet. The power and presence of the Holy Spirit will reach into homes, into schools, into dorms, into business places, through cell phones and computers and televisions. This will be the place where we record and touch the nations of the world. Now, for those of you who don't know, also just a few weeks ago, there was a lot of activity going on. There was a tornado that came through Round Rock. Many of you saw this on the news. That tornado actually touched this property. Now, miraculously, our half of the building was virtually undamaged. The other half of the building had the roof torn off. You see, we're working out a deal to where we're going to take over the entire property. But in the meantime, we just have the first half. And when that tornado hit, it did not touch this region. Why do I believe that happened? I believe God's hand of favor and protection is on this ministry. In fact, we had the contractor tell us that this was probably the most difficult job he's ever done. And he said it wasn't the materials, it wasn't the design, it wasn't the work that they had to do. He told us that the most difficult part was the fact that all of these things seemed to be coming against the construction of this studio. And so, we know that there is spiritual warfare taking place. The enemy does not want this place to be built. The enemy does not want this project to be completed. But that's too bad for the enemy, because as I said earlier, nothing is impossible when you put your faith in God. We believe big. We're putting our faith in a big God who does exceedingly abundantly above all we could ask or even imagine. Even as I stand here in this room, I'm reminded of a time when I began to broadcast that of my parents' garage. It was me, one camera, and three lights and a tiny little space in the garage. And as I would broadcast from that tiny space in the garage, it was hot, it was crammed, it was relatively low-tech. But in my heart, I knew that God was going to do something bigger. And every step of the way, God has met us. Think about the fact that we're expanding in a season of global recession. I talked to our CFO just a few days ago, and he gave me a report on the ministry. And he told me that miraculously, not only has the ministry not been affected by the recession, but it's actually grown in the midst of the recession. Now, why is that? Well, I believe that God rewards good stewardship. And when you put into practice the biblical laws of wisdom and faith and generosity, that invites the blessing of God. I can think of story after story of how God miraculously came through for this ministry in many seasons. You know, this isn't the first studio we've built. And each time we've built a studio, the ministry has expanded exponentially. And I look back, and I can see the hand of God in this ministry. And I can see how he's been so faithful to his word. I think of the time that we were building a studio in Paramount, California, our first one. And we needed $14,000 in order to do it. And God sent someone who, by their own admission, didn't even like me to fund that project in full. I think of our TV studio in Laundale, California. That was a six-figure miracle that we needed. Half of the money was raised by the support of generous viewers. And then when we reached the end of that support, God sent a man from Northern California to come and fund the rest. I think of the studio we most recently built in Cerritos, California. There again, we saw a good portion of the funds come in through online viewers such as yourself.  And now here we are, almost finished with phase one of Project DTV. And we're calling on you, God's people, to by faith get involved. God has been faithful every step of the way. What's waiting for you on the other side of your step of faith? I'll tell you, it's God-given destiny. And again, I can think back to growth spurt, after growth spurt, after growth spurt. And I'm here to stand as a testimony of God's faithfulness. Nothing is impossible when you put your faith in God. We need to stop living in fear. We need to stop worrying. I've discovered that so long as you're being a good steward and so long as you're practicing biblical generosity and so long as you're applying the wisdom of Scripture that God will bring it to pass. This is a God-given vision. We're doing this for his namesake. We're doing this that souls might come to the cross. And so as you look around, as I said, you're looking at a miracle in the making. Now, this is where I need your help. I need your help to finish this project. I know that God will bring this to pass. But do you know how he does that? He does that through the generosity of his children. Jesus said that you cannot serve two masters. You can't serve both God and money or mammon. And then he says something very interesting. He says, this is why I tell you to not be afraid. In other words, the way that we worship mammon, the way that we worship money is through worry. Every time you worry, every time you question if God is able, you're holding a worship service for mammon. You're putting your faith in mammon. I know this. You're generous. You, God's people, love the gospel. You love souls. And I truly know that your heart is to give. Your heart is to support. But sometimes the enemy can get to us, can't he? And the only reason that sometimes believers hold back is because maybe they're a little afraid. Maybe they're wondering what's waiting for them on the other side of their step of faith. And so they hesitate. The lie that the enemy tells us, the enemy lies in this way. If you give to that ministry, if you send that support, then you're going to lack. If you are generous toward what God is doing, if you're generous toward that project, then there won't be enough. But that is a lie of the enemy. For Jesus said, seek first the kingdom of God above all else and live righteously. And then all these things, what things? Those things He provides for you. They'll be added unto you. And so I challenge you, my friend, to stand with us in faith. We are stepping out big in faith. We are seeing growth, explosive growth in the middle of a recession. And I'm here to declare to you, I stand as a living testimony. God is faithful to His word and nothing is impossible. There's nothing to fear. The media is constantly pumping fear through the airwaves. They're speaking of economic collapse, the rise of inflation, the dwindling power of currency. All of that may or may not be true. I'm not an economist. I couldn't tell you. But I do know this. I've never seen the righteous forsaken nor their children begging for bread. I do know that even if what they're saying is true and most of the times it isn't, but even if what they're saying is true that God's going to take care of you. His eye is on the sparrow. Surely He watches over you. And it's with that knowledge knowing that God will take care of us. That's what frees us. That's what liberates us to be generous. And so now we're just about across the finish line. It is just within our grasp. Yes, we are almost there. Help us finish phase one of Project DTV by going right now to davidhernanisministries.com slash expand. Your gift of any amount will make all the difference in the world and will help to bring this God-given vision to pass. Thank you. God bless you. And remember, nothing is impossible with God. Also, help us spread the gospel of Jesus Christ in the power of the Holy Spirit. Make a one-time donation or become a monthly supporter by clicking on the donate link now.


I would like to introduce Dr. Garderay from the Hospital Saint-Antoine in Paris. Some of you know him already. He talked to us last AGM in October. So Dr. Garderay has to leave very, very in point. So here we have to stop in each way at 12.30. He's going to celebrate his birthday today and show he has to go back to his family. Thank you Dr. Garderay for coming here and you have the floor. Thank you very much. It's always a great pleasure to share with you the new drug developments to treat this disease. So actually the program is huge. It's both AL amyloidosis and myeloma, focusing on the new drugs and the clinical trials, the ongoing ones. Actually after I suggest that we start first with AL amyloidosis since Professor Mellini just made his talk. So I will move, sorry, to AL amyloidosis first and then come back to, yeah. So actually these are really two different diseases, AL amyloidosis and myeloma. Both come from you have abnormal plasmocytes, that's for sure. But the number of abnormal malignant plasmocytes are low in AL amyloidosis while there are much bigger number in myeloma.  While you understand that AL amyloidosis is a systemic disease and you have heart involvement, kidney involvement, GI involvement, neuropathy. So really different diseases but actually the treatment is more or less the same. The major, how do we treat this disease? That was already mentioned. There are two targets. For many years the only target was to get rid of the abnormal plasmocytes and this is still the case of course because the light chain comes from these abnormal cells. But now this is the brand new development. It's the ability of monoclonal antibodies targeting these fibrils, either as oligomer or full type fibrils that are destroying the organs. So this is really the major breakthrough and we have three monoclonal antibodies. So this talk will be split in two parts. First, how do we get rid of these abnormal plasmocytes? And second, how do we target the fibrils? There's a lot of overlapping you will see, Professor Mellini already mentioned, but anyway it's good to repeat. So he mentioned this major study. It's a major study because for many years the gold standard of AL amyloidosis treatment was and it still is the combination of a chemotherapy, Melfallon plus high dose steroids. He mentioned that steroids are very efficient to get rid of these abnormal plasmocytes, those are so-called M-dex, Melfallon plus dexamethasone. And obviously you know that we have new drugs for myeloma, but this is also true for AL amyloidosis because we are targeting the same abnormal plasmocytes and we have new proteasome inhibitors such as the first in class was bortezomy, Velcade, and it was also mentioned the other one, exasomy. So what was done was to combine to add to M-dex bortezomy and that was a major phase three randomized international study comparing M-dex plus or minus bortezomy. And so this is the schema of the trial, but the results have already been shown. The overall, the adverse events where let's say acceptable, a little bit more cytopenia, maybe trombosatopenia because Velcade does induce trombosatopenia and neuropathy because as you know Velcade does induce some kind of neuropathy. But the response was, you see, highly superior in the M-dex Velcade arm. That's the details on the organ response and on the hematological response. And these are the, that was already shown. You have a better time to second line therapy with the M-dex Velcade and even though the overall survival was superior but not statistically superior, if you look specifically to the subset of patients with the cardiac involvement, stage two, you do have an overall survival benefit adding Velcade to M-dex. And that's also the hematological response and the cardiac response. So that's the conclusion and that's what he said actually that in Pavia, now the goals, the new goal standard is to treat AL amyloid disease with M-dex plus Velcade. So this is important because we are moving from M-dex to M-dex Velcade. Now another study that has recently been published by his same team tested the emits, you know that we have the proteasome inhibitors but we have also the class the emits and we have thalidomide, ledalidomide and pomalidomide and they published, Pavia study published that for patients who have already been treated with the proteasome inhibitors, alkylating agents, ledalidomide, well you could treat them successfully with pomalidomide. So pomalidomide and in combination with DEX was efficacious in this setting and that's important and that's what he mentioned also that is treating quite often is AL amyloid disease patients with pomalidomide not in first line but in the relapse setting. So that's another treatment option for these patients. So targeting the plasmocytes, the new developments, M-dex plus Velcade and pomdex, pomalidomide dex. Now switching to the monoclonal antibodies, a third class, the proteasome inhibitors, the emits and now the monoclonal antibodies. And this was mentioned but this is really a breakthrough and I'm mentioning it's a breakthrough even in AL amyloid disease, even more in AL amyloid disease because the plasmocytes are limited and therefore if you kill this small number of plasmocytes, get rid of this small number of plasmocytes you have a very strong impact on treating your patients and this is true in AL amyloid disease and you will see it's obviously very true also for myeloma. And I'm just mentioning the way the monoclonal antibodies are acting and this is the classical way. We will come back on that but that was mentioned also. I'm not sure if it does have a big impact in AL amyloid disease but it does also have an immune effect and it restores, it brings back the immune effect to get rid of abnormal plasmocytes. So the first cases were published in October 2016 in blood, testing for the first time and that's the myoclinic in the U.S. In two cases of advanced lie chain amyloidosis and you see that these patients was already had received carfilzomib, cyclophosphamide, dexamethazone, he had been transplanted so really very advanced patient and he relapsed, you can see the lie chain and he was then finally treated by Daratumimab and he could reach a very deep response. So this is a very impressive response for such a patient. And that was shown again in another patient and you can see that actually it was almost undetectable. So very encouraging, very early results. And that's now, that's a clinical trial that is ongoing in France for patients who have AL amyloidosis and who do not reach at least VGPR as it was defined earlier then we are testing Daratumimab and we will see how effective it is. So for AL amyloidosis, not for myeloma, it's called amydara, well it's AL amyloidosis. So this is the first part, getting rid of the abnormal plasmocytes, m-dex plus bortezomib, pomalidomidex and Daratumimab. Now, how to get rid, and this is really new, that's why we are so excited. How do we get rid of the fibrils? And we do have at least three different types of fibrils. The first one is developed by Susan Lynch in the US, the second one by Pepe's in London, Pepe's team, and the third one worldwide, I would say. So I will not mention this one because it's at a very early stage of development. I will first start with this one, the anti-ACP, and you will notice that ACP, if you remember, is the protein that links to the fibrils, to the amyloidosis fibril. So this antibody is not only effective for AL amyloidosis, but it's effective for all amyloidosis. You remember the first slide of Professor Melini, you have all different kinds of amyloidosis, but all these amyloidosis, they link to ACP. So if it is efficacious, it will work for all amyloidosis, while this one, and you will see, the first preliminary results are outstanding, but it focuses only on AL amyloidosis. So I will just remind you that was published two years ago in the New England Journal of Medicine, and that was the first time that we heard from the PEPIS team in London about this very active antibody, the antibody against ACP. So it's actually a two-faces treatment. First, they give the antibody to get rid of the circulating ACP, then they had another antibody and that will get rid of the fibrils and remove actually the amyloidosis. So that's what is described here, and it was especially efficacious for liver amyloidosis, and you could see before and after with these two cases, and that was, I'm just showing you the number of patients and the different organs and the different amyloidosis that have been treated. So again, not only AL, but all kinds of amyloidosis, and so far it's very efficacious for liver amyloidosis. We have not heard too much since then, since this publication, but I believe it's trials are, I guess, ongoing. Now we're moving to the NEOD, that was already mentioned, and I must say that was first published also, you see, a year ago, and it was updated at the last ASH meeting, and the results are absolutely, so a small number of patients, of course, but the results are absolutely outstanding. You see the cardiac response, and I would like to stress again that what Professor Mellini said, cardiac is really the major problem, and if there is, I would like to say it again, a take home message on AL amyloidosis, Professor Mellini said it many times, but in my clinic, the patients that I see, they do have cardiac involvement, and when there is cardiac involvement, it may improve with the monoclonal antibody and the treatments that I've just mentioned, it's very difficult to treat them successfully, very difficult. So the take home message is really the early diagnosis, and you may have a major impact in advertising, because indeed it's a rare disease, you know, from Professor Mellini it's not so rare, it's like Hodgkin disease, but you know, a GP, he will see one or two myeloma patients in his whole life, and never AL amyloidosis, I mean never, but he should see at least one, and that's the one that he should diagnose very early, because that will make a difference. Otherwise, once you reach the stage of heart involvement, it becomes very difficult, really. However, and that's why it was so outstanding in these results, you know, we could see that the anti-probian period, that reflects the heart functioning, such a decrease, you know, with this treatment, and quite quickly, you see, made in time to response is two months, so this is quick, quick response, and so biologically, at least, the anti-probian BNP decreased. I remember that we discussed that with Protena in terms of heart function, because this is really what we want, I'm not so sure, but we can ask our colleague from the company. So outstanding result for heart, outstanding result for kidney, you remember, kidney is very easy, proteinuria, you see, you remember proteinuria, 50 cents to monitor. You see the decrease of proteinuria, and also that was outstanding, and I think if I remember correctly, that was, you correct me if I'm wrong, the first time that we could show response on the neuropathy, if I'm correct. So you see, the neuropathy was also much improved with this treatment. And that was not related to the previous treatment, so really all the signals were showing that indeed it was the monoclonal antibody, the so-called NaOD that was active in this setting. And therefore, two studies were launched, and that was already mentioned, the so-called vital, and you understand why it is vital, it was specifically for patients with heart involvement, and the other one, the pronto, was for patients who did not reach the VGPR, the so-called VGPR stage, that is the initial goal that we want to treat AL amyloidosis. So actually, I don't know how many patients have been unrolled, but I understand that it's been very successful because the unrollment is closed, and then of course the trial is still ongoing, and we are eagerly waiting for the results. How many patients did you include in both studies? In less than a year, I know, something like that. Yeah, so very successful trial. In amyloidosis ever. Yeah, so we are really looking forward to the results. So that's the schema of the vital study, and so you see standard of care, or placebo or NaOD, and the pronto study, this is for patients with at least one line of therapy, not reaching a VGPR, and again it's NaOD or placebo. So we will see the results. That was mentioned by Professor Malini, and this is the way it goes in myeloma, and I suspect, but Professor Malini will tell, but he mentioned that we are combining. We are combining the new mm, you want mm. This is almost my last slide. So we are combining. Now the new standard is MDEX Velcade. But of course you want to add Daratumimab, MDEX Velcade, plus a monoclonal antibody. And actually there is such a study. I mean it's not MDEX Velcade, but it's CyBordy, which is another gold standard to treat amyloidosis. So we will combine with or without Daratumimab, and so that was my conclusion for the future treatment of alamyloidosis. Of course I don't have the expertise of Professor Malini, but looking at the way we are treating myeloma, I was wondering if maybe in the future it will not be MDEX Velcade or CyBordy, plus Daratumimab, and plus an entire fibril. So you will discuss with Professor Malini. Of course he mentioned already this as a cost, but that's another issue. So definitely, and I will end my talk also with this, I think these monoclonal antibodies have really changed completely the landscape, not only of alamyloidosis, but also on myeloma. So if you have one question on alamyloidosis, I will answer, and then I'm moving to myeloma. Any question? Yes, go ahead. You had a slide about the pronto endpoint definition. Do you have a slide for the vital? I was not, sorry. You showed it in the endpoint, whereas we said, I mean hospitalization and mortality for the vital. Vital? Time to composite or cause mortality or cardiac hospitalization. So, moving to myeloma, new trials. So, you know, I had to make choices, right? Because, so, I'll start with this one, you know. This one is about Ixazomim.  I'm just showing you this slide to show you that Ixazomim is tested, is trial at every stage of myeloma. But this is only a real small number among the 90 studies that are ongoing. So, you know, it's called Tumalin. You're probably familiar with this. So, I decided that I will have to make a choice. I will not go through carfilzomim and even pomalidomide and all these exciting new drugs. So, I will focus only on immunotherapy. Why will I focus on immunotherapy? Because it's extremely exciting. We believe it's a completely changing field. I will tell you a small short story. 20 years ago, I did dendritic cells, and I loaded the dendritic cells with immunoglobulins, and I tried to induce T cells, T cells directing against the plasmocytes. So, I completely failed. I mean, not completely. I published the results, the negative results, and I stated all the reasons why it failed. But at that time, for example, we had never heard of checkpoints, you know, that we know are so important. But some years later, my wife told me that actually she had been very impressed by the way I was talking about dendritic cells and that's part of my success. So, I did not completely fail in trying immunotherapy in myeloma. But for many years, people never did not believe in immunotherapy. And actually now it's different. You see this slide is really nice. It explains the different, the major ways to target, you know, the plasmocytes, the abnormal plasmocytes, either by a monoclonal antibody or by core T cells. So, you take the T cells of the patient and with a brand new technology, you put at the surface very specific receptors that will target the cancer antigen on the plasmocytes. So, this is extremely exciting. And you have also the checkpoint inhibitors and I will come back on that. You know that the immune system is ready to get rid of the cancer but cannot properly act because there are inhibitors. So, we inhibit the inhibitors. This is the so-called checkpoint inhibitors and then we release the break and it works actually. As you know, it works very efficiently in many solid tumors and it does work to some extent also in immunology and specifically in myeloma. And I will not go too much on this other pathway. So, let's focus first on monoclonal antibodies again. So, we are, we have in myeloma especially the two targets, SLAM7 or CS1 and CD38 that we already mentioned. And looking at CD38, we have three antibodies, DARA that I've already mentioned. SAR, is a tuximab developed by Sanofi and a third one at a much earlier development. But you could see that we have many other targets in development, only monoclonal antibodies. And the very first one I should mention is elotuzumab. Elotuzumab was the first one to prove that a monoclonal antibody could be efficient in myeloma. We had tried many antibodies, anti-IL6, anti-CD20 and it did not work. Well, this one was the first one, but I must say it does work in combination. It does not work by itself and specifically it needs to be combined with an image. It works best with an image. So, we should recognize that this is the very first active monoclonal antibody in myeloma. But, just right after, arrived daratumumab. And daratumumab, you know, not only is it very effective also by itself because I mentioned to you that it does act like all monoclonal antibodies, but also it regulates the immune system of the patient and it boosts the immune system. Actually that's the way we understand why it does work as a monotherapy. So, I'm emphasizing actually daratumumab because it's difficult for haelotuzumab to develop while daratumumab is, I must say, more efficient. And you can see that it is, it has been trialed everywhere. Of course, you're very familiar, I'm sure. I'm not mentioning it in the relapse setting, extremely encouraging results, especially the Pollux trial, Revlimid-dex plus daratumumab with an expected PFS in the relapse expected. I mean, not rich yet, but expected of around maybe 40 months. I mean, that's what I heard not too long ago while so far the best relapse treatment was the combination of carfilzomib, Revlimid-dex with a medium PFS of 28 months. So, you see the jump, if I may say. So, extremely encouraging in the relapse setting. The Cassiopeia, I will mention that. And we have just finished enrollment, more than 1,000 patients, a joint study with the oven and the IFM. And I will come back on that, but also, so that's in the front light setting, in the transplant-eligible, transplant-inelegible Maya study. So, definitely daratumumab will make a paradigm shift in the treatment of myeloma. And I will mention also Isatuximab, so its development is not as developed as it is with daratumumab, but you can see, you have many different studies, mostly in the relapse setting, but also for smoldering myeloma. And in France, I mean, this trial will start and we will enroll patients in the so-called Icaria trial, so that's in the relapse setting. It's spondex plus or minus Isatuximab. So, this is just the beginning and the IFM will be part of this important study. So, first, the monoclonal antibodies. Second, the checkpoint inhibitors that I mentioned and I'm sure you're familiar with. This is the schema showing the tumor, the myeloma abnormal myeloma cells and expressing PDL1 and inhibiting actually the active immune system of the patient. So, the patient cannot get rid of the myeloma cells and we do have now checkpoint inhibitors. So, interacting between PDL1 and PDL1 and it is, as you know, currently in development, mostly these two studies, Lendex plus or minus, I mean, it's not plus or minus, it's a phase two study, plus pambrolizumab and pondex plus pambrolizumab. So, this is ongoing in terms of checkpoint inhibitors in myeloma. Now, I would like to turn to vaccines that I mentioned and then to CAR-T cells because CAR-T cells look very promising. So, first, vaccines. So, the idea is that you will... So, this treatment will only be tested in the maintenance because you don't expect to have a very strong immune response, so strong that you could treat an active myeloma. But in the maintenance phase, it could be successful. So, you see, that's what I tried to do 20 years ago, dendritic cells fused with myeloma cells and you hope that you will boost the immune system and get rid of the myeloma. So, either in the maintenance phase or in the early phase of myeloma, so-called smoldering myeloma. So, this is actually currently tested and I know that Davidan in the US with the big transplant, American transplant network is testing this vaccine strategy in the maintenance phase post-autologous stem cell transplantation. But here you can see other different vaccine strategies. Monoclonal antibodies, checkpoint inhibitors, vaccines and I will close this immune overview, immune therapy overview with the CAR T cells. So CAR T cells have been presented by the Americans and also by Chinese, they do a lot of CAR T cells in China and I was at the ASCO meeting in Chicago months ago or two months ago and there was a neural presentation by a Chinese team and extremely impressive. Really, with limited toxicity, no cytokine release syndrome, you know this is a major issue with that type of technology, no neuropathy of the central nervous system and highly efficient. So efficient that you wonder if it's really true but that was presented in a major congress and of course it's still very difficult, the technology is huge, a very limited number of centers can actually produce CAR T cells. In France we are testing in one center, I don't know about Italy, do you have anyone doing CAR T cells? I think we are exploring in Torino, in Milan also, Coradini and we are also trying it in Pavia because it's ideal in Amelidosi because you have such a small clone but we are concerned about the side effects. It's still at a very early stage but you remember the very first paper was published in one case with a CD19 target and that was shown you could see the monoclonal peak decreasing to zero and that was the very first reported case and you could see the disappearance of the plasmocytes after this treatment and now it's very important also to choose the target so now we are moving from CD19 this was probably not the best target to BCMA and BCMA are currently the best target in the field of CAR T cells in myeloma so that's what I was mentioning with the Chinese team, actually it was a CAR T cells directed to BCMA so these are different trials ongoing with cell therapy, immune cell therapy in myeloma and these are the results you see that's the American team but I must say that the Chinese it was even more impressive I would like also to mention that you have what we call the bi-specific antibodies and specifically the bytes so one side targets the tumor the tumor and


A Tiger. Financial news. Network. TFN News Update. Welcome folks to Dow. Dow Industries closed down 47 Nasdaq down 13 S&Ps off 2.5. Sideways Day out here basically. And I expect that's what we're going to get right up until Wednesday at 2 o'clock folks when the statement comes out then the news conference starts at 2.30. Gold contract down $10.40 trading at $19.88 an ounce. Silver off 2 cents. $25.20 an ounce. Both gold and silver didn't hold price as the dollar climbed off its lows. Oil off $1.75.77. A barrel notes and bonds. A 10-year note. Down 24 ticks trading 114.14 a 30-year offer full two points plus nine ticks at $129.12 and $King dollar. $King dollar off 474 ticks trading 102.133. The Euro at 109. The Yen at 137 and the British pound at 124 to one U.S. dollar. We're going to take a look at the spy. You're going to see the sideways moves. You do have light volume. No doubt about this. And I expect we're going to have light volume right until Wednesday. You know, the spy got to 4.17. Closed out at 4.15. We go into the queues. You're going to see the same type of setup inside the queues. Queues out here. We got to 3.23. Close at 3.22. And you had light volume. But you're hanging at highs out here. And gold. Gold contract as well as silver didn't hold price. Had a nice move up. Gave it all back. Gold got up to the price point of 2015. Closed out at 1988. Now that being said, we still have some pretty good volume inside the gold market. Silver had a huge amount of volume. So silver gave up a dollar. Now that's a monster move. And that's what silver is known for, folks, up or down. That being said, though, you get 73,000 contracts on the silver market. That's big contract volume. That saying you're going to be right back top side inside of the silver market. And we go to the gold. I mean, the dollar. And this is what it's all about. The dollar right now. Bottom line. Up 4.77. 102. That thing wants to go to 106. Have a great night, folks. Have a safe night. Come back and visit Tommy tomorrow morning. Kicks us off at 9 a.m. Great show, folks. We'll get them, folks.