Storm in a Tea-Cup by Helen Chersky, read by Chloe Massey. While I was a university student, I spent a while doing physics revision at my Nana's house. Nana, a down-to-earth northerner, was very impressed when I told her that I was studying the structure of the atom. Ooh! she said. And what can you do when you know that? It is a very good question. Introduction. We live on the edge, perched on the boundary between planet Earth and the rest of the universe. On a clear night, anyone can admire the vast legions of bright stars, familiar and permanent, landmarks unique to our place in the cosmos. Every human civilization has seen the stars, but no one has touched them. Our home here on Earth is the opposite. Messy, changeable, bursting with novelty and full of things that we touch and tweak every day. This is the place to look if you're interested in what makes the universe tick. The physical world is full of startling variety, caused by the same principles and the same atoms, combining in different ways to produce a rich bounty of outcomes. But this diversity isn't random. Our world is full of patterns. If you pour milk into your tea and give it a quick stir, you'll see a swirl, a spiral of two fluids circling each other while barely touching. In your teacup, the spiral lasts just a few seconds before the two liquids mix completely. But it was there for long enough to be seen, a brief reminder that liquids mix in beautiful swirling patterns and not by merging instantaneously. The same pattern can be seen in other places, too, for the same reason. If you look down on the Earth from space, you will often see very similar swirls in the clouds, made where warm air and cold air waltz around each other instead of mixing directly. In Britain, these swirls come rolling across the Atlantic from the West on a regular basis, causing ornatoriously changeable weather. They form at the boundary between cold polar air to the north and warm tropical air to the south. The cool and warm air chase each other around in circles, and you can see the pattern clearly on satellite images. We know these swirls as depressions or cyclones, and we experience rapid changes between wind, rain and sunshine as the arms of the spiral spin past. A rotating storm might seem to have very little in common with a stirred mug of tea, but the similarity in the patterns is more than coincidence. It's a clue that hints at something more fundamental. Hidden beneath both is a systematic basis for all such for...


Lux presents Hollywood. Rio Theatre brings you Ida Lupino and Paul Henry in Now Voyager with Dane May Whitty and Albert Decker. Ladies and gentlemen, your producer, Mr. Cecil B. DeMille. Greetings from Hollywood, ladies and gentlemen. Amid all the hustle and bustle of these rough days has come a love story so fine and moving that it's gone straight to the heart of America. It's Warner Brothers' distinguished motion picture, Now Voyager. Co-starring tonight with Ida Lupino, we have one of the most sensational newcomers Hollywood has seen in many a day. He pronounces his name Paul Henry. He and Ida Lupino have just finished the picture devotion at Warner Brothers. And tonight you'll also hear two of Hollywood's finest character players, Dane May Whitty and Albert Decker. Ida Lupino's part is a challenge to any actress because in Now Voyager, she really plays two women. The girl who lives under the domination of her mother and the woman who learns to meet love on its own terms. I believe this play has a universal appeal and so apparently there's a product behind it, Lux Flakes. Take this letter from a flyer in Egypt. Out here we do our own doby. That means laundry. Our heating apparatus is a four gallon gasoline tin cut in half and about four inches of dirt put in the bottle. All you have to do is pour in a little gasoline until the dirt is soaked. Toss in a match, put your water tin on top and there's your hot water. I was scrubbing away, sitting on a bum pin with a wash tin full of doby trying to get the stuff clean. And I did it too, but I bet it was mainly due to what I was using, Lux. Yep, they even have that out here. Well, ladies and gentlemen, that's the way it's done in Egypt. It still sounds a little explosive to me, but he's on the right track with Lux Flakes. And we're on the right track with a play like Now Voyager. And here's the curtain for act one, starring Ida Lapino as Charlotte Vale and Paul Henryd as Jerry Durance, with Dame May Whitty as Mrs. Vale and Albert Decker as Dr. Jackwood. Untold once, by life and land, Mayor granted, Now Voyager, sale thou forth to seek and find. I heard those words for the first time from Dr. Jackwood in my room at his sanatorium. I knew what he meant. I'd been there three months, and now I was cured. I was well again. But how could he be sure? How could I be sure? I wonder what Dr. Jackwood thought of me the first day we met, the time he came to our house. I remember the way he stood in the drawing room smiling at me so gently.  And my mother was not my mother's idea to bring Dr. Jackwood to Phoenix. My mother believed only in strength, never in weakness. What was it you said that day? Oh, yes, she said, I'm ashamed of you, Charlotte. It was Lisa suggesting to bring Dr. Jackwood here, not mine. Your sister says that your recent peculiarities, your fits of crying indicate that you're on the verge of a nervous breakdown. Is that what you're trying to achieve? Well, Charlotte, has the cat got your tongue? Mother, please! Be quiet, Lisa. Charlotte, Dr. Jackwood has a sanatorium in Vermont, I believe. Probably one of those places with a high wire fence and yowling inmate. Mrs. Vail, I wouldn't want anyone to have that mistaken notion. Cascade is just a place in the country. People come there when they're tired. The very words, psychiatry, Charlotte.  There's nothing shameful in my work, Mrs. Vail, or frightening or anything else.  They don't know which way to take. I just put up a signpost saying, not that way, this way. Well, Charlotte, would you like Dr. Jackwood to point the way for you? If you should want me, I shall be in my room. Charlotte, come back here at once. Please don't. I'd like to speak to her alone. Excuse me. Oh, Miss Charlotte, will you wait, please? Yes. Miss Charlotte, I wonder if I might ask you a favor. Will you be nice enough to show me around this house? One doesn't often get a chance to view the Vail residence. Very well, Dr. Jackwood. Thank you. There is the room in which I was born. My mother's room. You may look at it if you like. It's a fine room, but I'd rather see your room. I'd rather see what your room is like. I'm not your patient yet, Doctor. Well, now nobody thinks you ever will be. Of course, if you'd rather not. It's on the floor above. When I was 17, I stayed out once until after midnight. That creaky step hasn't been fixed since. I'm not sure I know what you mean. My mother heard it. This way, Doctor. I keep my door locked. Make a note of it, Doctor. Significant, isn't it? Well, it signifies it's your door. I've never heard it said that a woman's home is not her castle. My castle, Doctor. Well, you're comfortable here, aren't you? Yes, I try to be. I'm here a good part of the time. Hello. What's this over here? A work table? Yes. Ivory carving. Did you make this cigarette box? Why shouldn't I? The point is how you could. I have a real admiration for people who are clever with their hands. I was always clumsy with my own. I would say that you are one of the least clumsy persons I've ever known. You may have one of these boxes if you like. May I really? Thank you very much. Yes, I'll get you something to wrap it in. Don't bother. Oh, you wouldn't happen to have a cigarette hidden away someplace, would you? Hidden? Do you think I hide cigarettes in my room, Doctor? No, no, I meant... Where do I hide them, Doctor? On the shelves behind the books? Cigarettes and medicated sherry and novels my mother would never allow me to read. Please, it was only the box that reminded me. How very perceiving you are, Doctor. How very right you are. You see, I was about to hide this album. You really should read it. It wouldn't do if you'd have come all the way up here and missed your amusement. Read it, Doctor. The intimate journal of Miss Charlotte Bale since then. Won't anything convince you that I do not wish to cry? Oh, but you must cry. I insist that you do.  We were sailing up the coast of Africa. You wouldn't have known me then. I was 20 then when I was in love. Miss Bale?  I'm not. There's a picture. Isn't he handsome? I'd never met a man like Leslie before. I'd hardly even met a man. Mother saw to that. I had to wear simple girlish rocks and flat shoes. And my glasses. I was never allowed to take off my glasses. You'll never get another pair of eyes, my mother used to say. But Leslie loved it. Yes, he did. He ordered a marrying. But you see, it was only the radio officer and he wasn't good enough for a veil of Boston. He wasn't suitable, my mother said, so she smashed it up. And what man is suitable, Doctor? She's never found one. What man would come along and look at me and say, I want you. My mother disapproves of the folder rolls of diet. I wear these shoes. You see, my mother approves of sensible shoes. I am my mother's well-loved daughter. I am her companion. I am her servant. My mother says...  Oh, here now. Look up here.  If you spoil them with tears. Dr. Jackson, can you help me? Help you? When you were talking down here. When you talked about the fork in the road. There are other forks further along the road. So many. You don't need my help. Put away your book and come downstairs. I'll go ahead. It's just as I said, isn't it? Just not. Mrs. Vail. Charlotte's no more ill than a moating canary. Of course she's my youngest, you know. The child of my age.  I suppose it's true that all late children are marked. Often such children are not wanted. That can mark them. Dr. Jackwitt, are you telling me... I have been trying to tell you that your daughter is seriously ill. Thanks to you. Thanks to me? If you had deliberately and maliciously planned to destroy your daughter's life, you couldn't have done it more completely. How? By having exercised a mother's rights? A mother's rights. A model. A child has rights to discover her own mistakes, to make her own way to grow and blossom in her own particular soil. Are you getting into botany, doctor? Are we flowers? I am trying to help your daughter. I suggest a few weeks at Cascade. I spent three months at Cascade. Outwardly, Dr. Jackwitt had worked lyrical. I'd lost weight. I was looking better. My hands were steady. Inwardly, I didn't know. And then came that morning when Dr. Jackwitt told me I could leave. The time has come for you to get out of the nest, Charlotte. Try your own wings.  No.   Meet people. Talk to them. But I... I'd be afraid I... Charlotte, the other day I referred to a quotation. Remember? Yes. Said it was from Walt Whitman. That's right. Well, I've had it looked up. He puts into words what I'd like to say to you. And far better than I could ever express it. He says, untold one, by life and land, may I grant it. Now, Voyager, sail thou forth to seek them fine. I sailed in a week. A pleasure cruise to South America. On the passenger list, I was René Beauchamp. I stayed in my cabin most of the time. But at campus, I decided to go ashore. As I came down the steps into the tender, I felt people looking at me. They must have known my clothes had been borrowed. You might be able to fool your mirror by wearing lipstick and plucking your eyebrows.  They know. At the bottom of the ladder, a man was smiling at me. In a panic, I turned and started back to my state form. Excuse me. Yes. What is it? Excuse me, but are you Miss René Beauchamp? Yes. Well, my name is Jerry Durance. Miss Beauchamp, it seems you have the only short carriage left. The steward suggested that you might be willing to share it with somebody. Well, really, I... I know it's an inconvenience. If it's too much, she'll say so. Though, of course not. If you can stand it, I think I should be able to. Thank you. Do you like rum drinks? Yes, these are very good. I've enjoyed myself today. Have you? Yes. You know, Miss Beauchamp, you're quite different from what I expected. How am I different? Well, you are so much more comfortable to talk to, Miss Beauchamp. So much... Please listen, I'm not Miss Beauchamp. I beg your pardon. René Beauchamp is out in Arizona somewhere. I took her space at the last moment. I... I don't know why I'm telling you all this. It's a stranger.  You know who I am. I'm sorry. My name is Vale. If it ever appears on the passenger list, it will be C. Vale, Boston, Massachusetts. One of the Vales of Boston. One of the lesser ones. Well, which one? Miss or Mrs? It's Aunt. Every family has one, you know. But Aunt what? My name is Charlotte Vale. Miss Charlotte Vale. Do you mind if we go? Miss Vale, I hope I didn't offend you. It's like me to blunder just another screwing to ask you for a favor. I have some shopping to do for my daughters and, well, I need a woman's help. Well, of course. A Spencer Aunt is an ideal person to select presents for young girls. Miss Vale, I wish I understood you. He wishes he understood me. He wishes. He's just right for Beatrice. And the sweater for Tina. How old is Tina? Yeah. I have a picture. This is my hair. And all girls. Oh, I see. Who is that missing? Oh, that's Isabelle, my wife. The picture isn't very good of her. She'd only looked up and smiled. That's Beatrice next to her. Then there must be Tina sitting cross-legged on the grass. Yes. We hope she won't have to wear glasses all her life. Tina wouldn't smile for me, either.  Does Tina know she wasn't wanted? There's an odd remark. Yes, I'm sorry. I don't know why I made it. I mean odd because it hits across the truth. Even before she was born, her mother said, here. Here's a slight offering for being my guy today. It's a mixture of several kinds of flowers. It's called Jolly Fleur. Thank you very much. I'll put some on my handkerchief tonight. Will you? Good. Let's meet in the bar for a cocktail before dinner. Hello.  You made a striking impression over there. She stood in the doorway looking for me. Yes, sir. How about they put on too much lipstick? No, no. Not that I noticed. But I didn't notice the wrap at once. Oh. What's that? What's what? Something on your app. Why, spin it on. A note.  Would you unpin it, please? Read it. This cape always makes an impression. I hope it will do the same for you. What does it mean? It means that this cape belongs to René Beauchamp. She lent it to me. Oh, I see. Your wings are borrowed. Well, they suit you just the same. No, they don't. They suit me at all.  You're quite right, you know. Someone is playing a joke on me. But it's far funnier than you realize. You aren't going, are you? Yes, if you don't mind. Well, Jerry. Mac. In depth, too. How are you? Hi, Jerry. We're joining our shift. Wonderful. Oh. These are my old friends, Deb McIntyre and Frank. And my new friend, Miss Beauchamp. How do you do? How do you do? Is this René Beauchamp? No, no. Another one altogether. This is Camille Beauchamp. Excuse me, please. Good night. Good night. Oh, wait, Miss Beauchamp. See you later, Deb. Sure. Please, wait. Why did you run out on me? Did you have to introduce me like that? It wasn't up to me to let the cat out of the bag. Did I do wrong? Why did you call me Camille? Well, it was the only French name I could think of. Besides, Sviti. I suppose that's meant to be funny. My wife calls my lighter woman trying to be funny. But I intended the company. In that dress, you're rather likely Camille. Yes, likely. You have a very high opinion of yourself, have you? No, perhaps this will help you know why. You showed me your album. I really must show you mine.  Family is right. Who is this? Your grandmother? No, my mother. A very strong character, I'd say. And these? My brothers and their wives. They're so much older. Who is the fat lady with the heavy brows and all the hair? Sister-in-law. And where are you? Taking the picture? No. The fat lady with the heavy brows and all the hair. I'm poor Aunt Charlotte. And I've been ill. I've been in the sanatorium for three months, and I'm not well yet. Feeling better? Yes, much. Thanks to you. Oh, many, many thanks to you. Thanks for what? Oh, I don't know. Sharing my carriage today. Walking my legs off site seeing. Helping me feel at the where of few moments. Almost felt alive. Thank you, Jerry. Good night. Jerry's, I learned about Jerry Durance in his life at home. With his friend Deb, who told me. Deb talked a great deal. And I think what a woman like Isabelle can do to a man like Jerry, it makes me born. Her martyrdom. And her jealousy. But she can't have any reason to be jealous. If you mean does Jerry have flings with other women? No. But mostly she's jealous of Tina. The child? Yes, the child she never wanted. And so I found out that he was unhappy too. And then one evening in Rio, our car broke down on the mountainside. He told me that night he'd been an architect once. It's the only work he really loved. His wife had asked him to give it up. We talked all night, Jerry and I. Toward dawn I lay down beside the fire pit. When he thought I was sleeping, he leaned over quietly and just my cheek. My boat sailed without me. The next night back at the hotel, we stood on the balcony looking over the harbor. You can rejoin your cruise in Buenos Aires. There's a plane going down there first thing in the morning. And there's another plane going down in five days. You'll get there the same day as your ship. Oh? You know anybody in Buenos Aires? No. It seems a shame to rush down there to spend five days alone. You'll be busy here. Oh, my business can wait. And we did start off for a tour. Yes, as we started off to somewhere. If I promise to sit at a different table in a dining room and say, good morning, Miss May. I hope you slept well. So people will hear me and never guess that I'm head over heels in love with you. Don't say no, Camille. Say, I've seen. I've seen. I must go in now. No, no. Not yet. Look at the harbor. Isn't it beautiful? Do you believe in immortality? I don't know. Do you? I want to believe that there is a chance for such happiness to be carried on somehow. Somewhere. Are you so happy, then? Close to it. Getting warmer and warmer, as we used to say as kids. Remember? Look out, or you'll get burned, we used to say. Are you afraid of getting burned if you get too close to happiness? Oh, mercy, no. I'm immune to happiness and therefore to burn. You weren't immune last night on the mountain. You call that happiness? Only a small part. There are other kinds. Such as? Having fun together. Getting a kick out of simple little things or out of beauty like this. Sharing confidences you wouldn't share with anybody else in all the world. Charlotte, won't you be honest and tell me that you are happy too? Since that night on the boat when you told me about your illness, I can't get you out of my mind. Nor out of my heart, either. If I were free, there would be only one thing I want to do. Proof you're not immune to happiness. Why, darling, you're crying.   These are only tears of gratitude. An old maid's gratitude. Don't talk like that. You see, no one ever called me darling before. Well, there's my plane. Yes. Thanks so much for the flowers, Jerry.  They don't matter. It's what's gone before. No, it's what can't go on after. But we'll see each other sometime. No, Jerry, we promised. You know, we're about to go home. Would it help you to know that I'll miss you every moment? So will I, Jerry. So will I. Say prayers to Sonoran. Say prayers to Sonoran. Goodbye. Darling. Goodbye. Goodbye, Jerry. Goodbye. He presents Ida Lupino and Paul Henry with they Mae Whitty and Albert Decker in the second act of Now Voyager. Meantime, here's our friend Libby Collins and an old tune to introduce a new showing of wartime clothes she'll tell you about. Thanks, Mr. Kennedy. I wanted the Arkansas Travelers a kind of salute to the star of our clothes show. She's a lovely girl from La Panto, Arkansas, and she's certainly been doing a lot of traveling. Her name is Bonnie Beth Beiler, the maid of cotton for 1943. Bonnie Beth is traveling around the country this spring to show how smart and serviceable cotton clothes can be, how to make them last longer through proper care and how easy and inexpensive it is to have just the kind we want when we make them ourselves. Oh, so this is a make-it-yourself fashion show. Yes, it's a save by sewing, save more by luxing show. We call it Luxible Cartons for Active Service. The clothes are really lovely, and every single one of them is Luxible.  They've all been luxe over and over, but they're still fresh and new looking. Where is the show now, Libby? This week, Bonnie Beth is in Baltimore in Boston, and next week, that's National Cotton Week, she'll be in Brooklyn. After that, she goes to Philadelphia in other important cities. The store where she appears in the time of the show will be announced in the newspapers. I do hope a lot of you will see the show. You can copy any dress in it forever so little and ever so easily, too. They're cut from McCall patterns with a printed cutting line, and on each pattern, there are hints to help you do a really professional job of dressmaking. And for a hint on care, you'll find it pays in longer wear to stick to new improved luxe flakes for all your washables. We pause now for station identification. This is the Columbia Broadcasting System. Two of now, Voyager, starring Ida Lupino, as Charlotte, and Paul Henry, as Jerry, with Dame May Whitty as Mrs. Vale, and Albert Decker as Dr. Jackward. Early in May, I returned to New York and went at once to see Dr. Jackward. He was delighted with the change he saw in me, but even he didn't know how much I changed or why. The final test was still to come when I went home to see Mother. I stood there outside her room, my heart beating wildly. In my mind, I kept hearing Dr. Jackward's words. Just remember that honoring one's parents is still a pretty good idea. You're going to be a shock to her, and I advise you to soften the blow. Give her time to get used to you. Hello, Mother. Though you've decided to come back. You're looking very well, Mother. Lisa told me you'd been ill, but I... Lisa knows nothing about me. Well, I can see you. Now, turn around. It's worse than Lisa led me to suppose. Much worse. Well, if you'd like me to go, Mother. Don't go. I've things to say to you. I've asked a number of the family to dinner tonight at 7.30. It's very nice of you, Mother. There'll be Lloyd and Rosa, Lisa and June, Mr. Livingston and Uncle Herbert. You mean Elliot Livingston? Yes. I shall be wearing my white lace gown tonight.  Oh, but, Mother, I've lost over 25 pounds. It won't fit. There's something else I want to say to you. Now that you've come home to take up your duties as a daughter again, I've dismissed the last mess. I've become used to having a room occupied on the same floor with me. And in view of my heart, I agree with the wise precaution. You will occupy your father's room from now on. I had will you move down all your things yesterday. But, Mother, you had no right to move my things. No right in my own house to move what I see fit. Yes, but, Mother, I think if you wear your glasses tonight, you'll be less of a shock to the others and take up whatever you've got on your face. As to your hair and eyebrows, you can say that often after a severe illness one loses one's hair, but you're letting yours grow as quickly as possible. Very well, Mother. If you'll excuse me, I think I'll go to my room. I knew then there had been no change in Mother, or in the house, or in me. That evening some flowers arrived. His flowers. A tiny box of chameleons. Yes, Mother? What are you doing in your old room? I had my things moved back. I'm going to sleep here. Didn't you understand I wished someone to sleep on the same floor with me? We can get one of the maids, Mother. Perhaps Hilda. So long as I pay the bills, I'm running this house. Please remember, you're a guest. Well, if I am one, please treat me like one, Mother. Your guest prefers to sleep in this room if you don't mind. This is no time for humour. Where do those flowers come from? From New York. Who sent them? Well, I've forgotten the name of the florist. In other words, you don't intend to tell me. Oh, Mother, I don't want to be disagreeable or unkind. I've come to live with you again here in the same house. It can't be in the same way. I've been living my own life for a long while now. It's impossible to go back to being treated like a child again. Where did you get that dress? I bought it in New York today. It's outrageous. Where's the black and white full-art? Well, I gave it to Hilda. She was so grateful. Oh, Mother, please be fair and meet me halfway. They told me before you were born that my recompense for having a late child was the comfort the child would be to me in my old age, especially if she was a girl. And on your first day home after six months' absence, you behave like this. Mother, wait for me. I'll go downstairs with you. Thank you. I'd prefer to go alone. Mother, please. You know you're not supposed to. Mother! Dora, come here! She fell. My mother fell. She was not badly hurt. Torn ligament in her leg. It was enough to keep her in bed during the party. I was a great surprise to the family that night, and as they left, one of the guests stayed on to speak to me at the door. Elliot Livingston. Well, Miss Vale? Well, Mr. Livingston?  Well, as a matter of fact, we have. Once and almost twice. I'm mystified. Well, when we were children, you were the only boy who danced with me at dancing schools. And the almost was when you were supposed to usher at my coming out party and didn't show up. I'm covered with shame. Well, I shouldn't have told you it wasn't nice. Well, I... I hope you're going to allow me to make up for my past rudeness. May I telephone you sometime? Of course, anytime. Good night. Good night. How was your ankle, Mother? Extremely painful. Oh, I'm so sorry. I've been doing some thinking as I've been lying here in pain, listening to you all having a good time downstairs. How much did that dress cost? Well, it was spikily expensive. I'll tell you about it in the morning. To whom did you charge it? To whom I've always charged my clothes, Mother. And do you expect me to pay for articles charged to me of which I do not approve? Well, I could pay for it myself. Save quite a little money. About five thousand dollars. Five thousand dollars won't last very long. Especially if your monthly allowance were to be discontinued. Oh, I see. I'm willing you should occupy your old room until I dismiss the nurse. That will give you a good chance to think over what I've said. I'm very glad to give a devoted daughter a home under my roof and pay all her expenses but not give she scorned by authority. Well, I could earn my own living, Mother. As a matter of fact, I've often thought about it. I'd make a very good head waitress in a cafe or I could... You may think that's very funny. But I guess you'll be laughing out of the other side of your face if I did carry out your suggestion. I don't think I would. I'm not afraid, Mother. I'm not afraid. Summer, winter, and then spring again. Between Mother and me, there was a sort of armed truth. In her own way, I think she respected me for what she called my stubbornness. And then there was a matter of early approval. Do you imagine there's a Livingston waiting for you on every corner? Well, I've been waiting to see how you'd feel about it, Mother. I do know as well as I do that it makes no difference to you how I feel about it. You always do exactly as you please. I think you're pleased. I'm nothing of the kind. I'm only so astonished that you have all the families that bring such a feather to the family cap. Well, then if you really do approve, Mother, dear boy... Oh, keep all that tough talk for Elliot.  That night I told Elliot I would marry him. Our wedding was set for June. Mother was pleased, and I was too. And then three weeks before the wedding, I saw Jerry again. In a room full of people, I saw him. It was just as if we'd never been apart. What's the matter, Charlotte? George, I think I know that man over there. Oh, Jerry Derns. He's been doing a job for me since March. Architect for the Medical Center. Shall I tell him your name or let him guess? Oh, let him guess. Right. Come along. Oh, Jerry, here's someone who thinks she's met you before. Yes? Of course. You do look familiar. Give me your name, George. I've got it. Beauchamp, isn't it? Camille Beauchamp. I'm sorry, Jerry, but you're wrong. No, my name is Bale. I met you on a pleasure cruise once. Oh, yes, Miss Bale. I hope you'll forgive me. I'll leave you two alone to make your own peace. George tells me you've been in Boston quite often, Mr. Durham. And I didn't know. Yes, several times. You look simply glorious. An architect? Oh, Jerry, I could cry with pride.  I've walked by your house on Marlborough Street. Once I almost rang the bell. Jerry, why didn't you? Tell me about Deb and Mack. You introduced me to them on the pleasure cruise, remember? They're all fine. And how is Tina? Well, Tina. We're having quite a bad time with Tina. Tell me about it. I'm afraid you've got to send her away somewhere. A doctor thinks you shouldn't be with her mother. I took her to see Dr. Jack with. He was highly recommended to me by this Camille Beauchon I mistook you for. Camille, I'm still horribly in love. Jerry. I must see you. May I come to your house tonight? I won't stay but ten minutes. I must talk to you. Yes, I'll be waiting. Hello? Hello, Charlotte? Jerry, why didn't you come? I've been home for hours. Why, Jerry? I wanted to tell you. Jerry, where are you now? I've got to see you. Are you at the station? Goodbye. You shouldn't have come. I had to, Jerry. I wanted to talk to you about Elliot. Why are you marrying him? Are you in love with him? No, not like we are. Not like that. I thought it might grow to be something like it. I thought I was getting over you, Jerry. Didn't think I'd ever see you again. You're not angry with me, are you? No. Only with myself. It was a rotten of me to make you care. Then because of some noble sense of duty to leave you to get over it, the best you could. And there isn't a thing I can do about it. Isabel depends on me more and more. She's ill and getting worse. And there is Tina. Even if I could chuck everything... I wouldn't let you, Jerry. I knew you were married. I applied in with my eyes wide open. But you said it would make you happy. And it has. I've got back my work. And that's due to you. Oh, Jerry, I've been hoping you'd say that. I have more understanding for Tina. I'm even kinder to Isabel. So don't blame yourself. Then don't you... It's different. No, it's not. Well, I'll tell you what you did to me, Jerry. You made me feel important. You were my first friend. And then when you fell in love with me, I was so proud. And when I came home, I needed something to make me feel proud. And then your convenience arrived at night. I knew you were thinking about me. Oh, darling, I could have walked into a den of Lyons. As a matter of fact, I did. The Lyons didn't hurt me. So please take back what you said. If you can marry that man and have a full and happy life, I will. I tried, Jerry. I look for you around every corner. Goodbye, darling. Goodbye, darling. I did try. I wanted to marry Elliot. It was no use. We broke it off by mutual consent. And I knew then I would never have a home of my own, or a man of my own, or a child of my own. Why did you break the engagement? Because I don't love him, mother. Have you no sense of obligation to your family or to me? Here, you have the chance to join our named veil with one of the finest families of the city. And you tell me that you're not in love.  Yes, I don't doubt it. And what do you intend to do with your life? Oh, I don't know. Get a calf in a parrot and live alone in single blessedness. I think you'll be ashamed to be born and live all your life for Charlotte Veil. Miss Charlotte Veil.  Dr. Jackson, tyranny is sometimes an expression of the maternal instinct. If that's a mother's love, I want no part of it. I didn't want to be born. You didn't want me either. It's been a calamity on both sides. Oh, mother, mother, let's not quarrel. You've been getting along together so well lately. With a horrid thing to say. Forgive me. Mother! Mother! She was sitting there and we quarreled. We quarreled. I did it. A pleasure starring Ida Lupino and Paul Henry with Dame May Whitty and Albert Decker. Here's some inside information for the women in our audience. Some inside-of-the-house information to help you spruce up your home for spring. Did you know that when you wash painted walls, you should use a sponge, squeeze almost dry so it won't drip in streaks, make light luck suds, and wash a little at a time. Rinse with clear water and dry with a clean cloth. But stick to gentle luck flakes for the job. Don't use strong soaps. As a government bulletin says, soaps containing free alkali can be as harmful to paint, varnish, lacquer, and malolium as they are to your skin. There's no harmful alkali in new improved lucks. 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We'll have a confidential little chat with our stars after the play. Now the curtain's rising for the third act of now, Voyager. Starring Ida Lupino and Paul Henry. It was Dame May Whitty and Albert Decker. I did it. I called with my mother as it killed her. I couldn't shake off the feeling of guilt. Who worse than worse than till at last I had to get away. I went back to the only refuge I'd ever known. Back to Cascade. How are you, Miss Veil? Dr. Jack acquired you were coming. Hello, Trask, I'm tired. Think I could go to my room right away? Of course you can. Come on. Miss Jack? Oh, the same as ever. Handing out common sense instead of sympathy. Wait a moment. Who is that child, Trask? Girl at the table. Christine Durant. A problem if I ever saw one. Tina Doddant. Jerry's child. She sat alone over a picture puzzle. Her eyes dull and staring behind her glasses. Her plain little face tightened into an expressionless mask. I went and stood beside her chair, but she turned away from me. Hello. What's the picture supposed to be? I don't know. Well, you mind if I join you? I'll collect all the pink pieces. I know who you are. You do? You're my mean nurse. No, I'm not. You can't fool me. And I know why you've come here. That's why I don't run away from this place again.  You see, I didn't know. What's your name? You know my name. That's why you stood there and stared at me. Oh, that was very rude of me. But you see, you reminded me of somebody. Who? Well, if you must know, myself. Of course, it's your age. Christine, your schedule calls for you to spend the evening with the young people next door. They don't want me. Oh, nonsense. Of course they want you. I've got a fine ping-pong game all fixed up for you. Barbara and Betty against you and Bob. But, but, but he's the best player here.  I'll die, I'll just die. Now you'll do nothing of the sort. Don't make me. Don't make me. Oh, don't make me. Now, Christine. Don't make a task. But the doctor wants Christine to have an exercise in the evening. But I'll see that she has an exercise. I'll take my car down to the town and leave it at the garage to be washed. Christine will go with me. Oh, yes. I'm sorry, Christine. Please let me go with this lady. I'll drink all my cocoa tonight, if you will. Oh, goodness sake, Christine. Don't carry on.  Oh, thank you. Sorry, Task. I couldn't help you. I thought you were too tired to do anything but just crawl in the bed. Close cascade has performed another miracle. Tina's room was next to mine. Late that night, I heard her. Tina. Tina, what's the matter? Don't be afraid. What is it, Tina? Don't leave me. No, I won't. You're asleep. Now come on. Tell me what's the matter.  Tina, you. I'm not pretty as a leaf, and they hate me. They all hate me. Who are they? Everybody. All the kids at school, and the trash, and the nurses, and the doctors. Oh, there must be something awfully wrong with me. Do you like them, Tina?  That's the trouble.  I bet you're only fooling me. Well, you try, I can see you.  And I think you're very pretty and very sweet, really. Oh, come on. Don't cry anymore. Why are you so good to me? Oh, because somebody was good to me once, and I needed somebody. Go to sleep, Tina. Close your eyes, and let your muscles go on them. There. That's better. Much better. Within my arms. Jerry's child was clinging to me. Jerry's child. You've done wonders for that child, Charlotte. Dr. Jackwith, I have a proposition to make to you. I want to take care of Tina. Pay attention to her. Make her feel once it's important. I'd like to take a camping in the woods. You know, she adores camping. Take her home to Boston with me. If she wanted to come, of course. Sounds like a wonderful break for her. Dr. Jackwith, how much do you remember about my trip to South America? Well, you sent some beautiful postcards. No, no, that's not what I mean. About an automobile trip I made from the man who was with me. I never knew the gentleman's name. You never told me. Well, I better tell you now. It was Tina's father. Tina's father? Is that all for the situation? Of course it does. I don't know anything about your relationship with Darren. I don't know how emotionally involved you are with him. Well, I'll tell you everything. It's over. That's it in two words. And Tina needs me. Well, you see, I've never been needed before. Well, I'm crazy. But if you promise to behave yourself... Oh, thank you. But you're only on probation. Remember what it says in the Bible. The Lord giveth and the Lord taketh away. How does it feel to be the Lord? Jerry had to be told, of course. And though we never saw him, he sent a message through Tina. He asked her to thank me. And then came the time when we returned to Boston. And the house was filled with young people. There was laughter and fun. And Tina coming down the stairs with a new dress and her hair all curled.  Tina, can this be Tina? Do I look nice? My first party dress. You look lovely. Do you really like me? I love you, darling.  Would you like to see my room, Daddy? Very much. Miss Vail will pardon us. How long are you going to call Miss Vail? What should I call her? I don't know. Would it sound too funny to call her my name for her? What name is that? We decided to go on the camping trip. I call her Camille. Camille, I think you would sound very nice indeed. Jerry, what are you doing here all alone? Come and join the party. I want to speak to you, Sharon. Jess, what about Jerry? I've decided to take Tina home. Take her home? Oh, but Jerry, you can't. Dr. Jack... I don't care what he says. No self-respecting man would allow such self-sacrifices yours to go on indefinitely. Oh, Jerry, that's the most conventional pious speech I ever heard in my life. I can't go on forever taking, taking, taking from you and giving nothing, darling. Oh, but Jerry, you will be giving. You'll be giving me Tina every single day. It's very kind of you to put it that way. Well then, is it something Tina has said? Don't you think she's happy here? Happy? If you told me upstairs, she loved you almost as much as she loves me. Well, Jerry, what is the reason? Is it something about us? Of course it's about us. Why didn't you marry Livingston? Because I came along and ruined him for you. And now my child comes along and claims all your attention and takes your whole life when you should be trying to find some man who'll make you happy. Some man who will. Here I've been laboring under the impression that you and I were so in sympathy. So one that you'd know without being out what could make me happy. And you come up here to talk about some man. Jerry, you haven't the slightest conception of what torture it is to love a man and be shut out, to be always an outsider in an extreme. Charlotte. When Tina said she'd come and stay with him. It's like a miracle. Like having my own child. A part of you. I thought you'd understand. Revolently you don't. Again, I've been just a sentimental fool. It's a tendency I have. Wait a minute. I was afraid you were keeping Tina out of pity. But there was no pity in your ridicule of me just now.  Do what you will. Ignore it, neglect it, starve it. It's stronger than both of us together. Please let me go. Oh, Charlotte. Jerry, listen. Dr. Jack would know about that. When he said I could take Tina, he said. You're on probation. Do you know what that means, Jerry? He allowed you to come here as a test. And if I can't stand the test, I'll lose Tina. And we'll lose each other. Darling, please help me. Shall we just have a cigarette on it? Yes, please. May I sometimes come here? Whatever you like, Jerry. It's your home too. There are people here who love you. To look at you and Tina. To share with you peace and contentment. Of course. And it won't be for this time only. That is, if you'll help me keep what we have. You could come here often. We could talk about your child. Our child. And will you be happy, Charlotte? Oh, Jerry. Don't let's ask for the moon. We have the stars. Here's one of our real life stories for you. It happened to Mrs. Irving C. Cobb of Fairfax Vermont. Seems she'd been struggling with, and doing a bit of grumbling about, the hard water they have in her little farmhouse. I guess a lot of you understand how she felt. Well, one day Mrs. Cobb found she didn't have any of her regular dish washing soap powder left. So she tossed a little luxe into her dishpan. And here's what she writes us. I was surprised and enormously pleased to find I had real suds. Suds that stayed suds too. That was something that never happened with my other powders and flakes. So no longer do I have excuses for grumbling over hard water. I'll use luxe for baths, shampoos as well as dishes and laundering for everything that calls for soap. Yes, new improved luxe flakes solve a lot of soap and water problems. Whether you have hard or soft water, give you wonderful suds in any kind of water. Rich, long lasting suds too. And very gentle suds. Use luxe for dishes. For the million and one things you do every day. It's thrifty and ever so much better for your hands. You'll find it in the same familiar blue box. But it's the new improved better than ever luxe flakes. Now, here's Mr. DeMille with our stars. The two voyagers have now voyaged her. They're taking a little trip back to the footlights. I do lapino and Paul Henry. I believe this is Paul's first curtain call in the Luxe Radio Theatre, Mr. DeMille. I'm willing to guarantee right now there'll be many more. Very kind of you, sir. You know, the first time I met Paul was at an air raid warden's meeting. I feel safer already with you two on the job. And of course, my husband in the marines. That brings up a social problem either. That must concern many women these days. When you go somewhere in the evening, do you go alone or do you have an escort? I suppose a date is the modern word. Well, sometimes I have a date. Confidentially. What does Louis think of that? Oh, I only go out with friends of his and he approves. For instance... Well, don't keep us in suspense. Well, I had one date the other night with my favorite jitterbug partner, Monty Woolley. And then, of course, I often visit the Henrys. Paul's wife is charming and they have a lovely home. Henry Fonda and his wife built it, Mr. DeMille. You should get a look at Paul washing dishes at the Hollywood canteen some night. You know, I think he's had some experience. Have you had any more adventures at the canteen either? Well, the other night I danced with a sailor and when the dance was over he said, would you do me a big favor? I've seen all your pictures and there's just one thing I wish you'd do. What was it, Anna? Miss Lupino, he said, would you please scream for me? You really made an impression. What's the play next week, Mr. DeMille? Well, I'm sure it'll be the talk of the town, Paul. Oh, that's fine. But what's the name of it? That's it. The Columbia Picture Success, the talk of the town. And our stars will be... Terry Grant, Gene Arthur and Ronald Coleman. Yes, I'm quite excited about it myself. It's a thrilling story that has comedy, drama and romance, plus three great stars, Terry Grant, Gene Arthur and Ronald Coleman. I'll wait right here so I'll be sure not to miss it. Good night, Mr. DeMille. Good night, everyone. Good night. Good night. Ladies and gentlemen, today is the birthday of an enterprise that's doing its part to bring victory nearer. It's the first anniversary of the USO Boston Soldiers and Sailors Buddies Club, where over a million men and women of our armed services have found a welcome in the home city of our sponsors. It's a great comfort to those of us who have sons and daughters and brothers and sisters in the service to know that thoughtful men and women are extending hospitality to them wherever they go. To this club in Boston and to all service clubs, we send our congratulations and good wishes. Our sponsors, the makers of Lux Flakes, join me in inviting you to be with us again next Monday night when the Lux Radio Theatre presents Terry Grant, Gene Arthur and Ronald Coleman in The Talk of the Town. Mr. Cecil B. DeMille saying good night to you from Hollywood. The picture now voyager was produced by Warner Brothers Studio, whose latest release is the production Mission to Moscow. Dame Mae Whitty appeared tonight through the courtesy of Metro-Goldwyn-Mayer and will soon be seen in the picture, slightly dangerous. Albert Decker's next picture is the Harry Sherman production, Buckskin Frontier. Heard in tonight's play were Mary Lou Harrington as Tina, Fred Mackay as Elliot Livingston, and Dwayne Thompson and Duran, Claudia Dell, Charles Seal and Stanley Ferrar. Our music was directed by Louis Silvers, and this is your announcer, John N. Kennedy, reminding you to tune in next Monday night to hear Terry Grant, Gene Arthur and Ronald Coleman in The Talk of the Town. Mothers, are you worried about food rationing and shortages? Yes, it's harder now to get vitamin-rich food, but have you thought about giving your family VIMS? VIMS are scientifically designed to help make meals complete. They give you all the vitamins government experts


Over sixty years have passed since Health Minister and Iron Bellum was put in charge of introducing a revolutionary new service for the people of the United Kingdom. A service which provided health care for the people which was based on a person's need not ability to pay. To date on the NHS birthday it's great to see that here in Wales it's as strong as ever. True to the simple idea that it will always be there for each to Wales three million people when they need it most. This is our most cherished and trusted public service. It works on an industrial scale transforming lives each and every day. So what in a day does our NHS do for us? Here are some of the numbers. Every day 100 babies are born. 50,000 people are seen via GP. 20,000 people see a dentist. 280,000 individual meddins are prescribed. 12,000 people have an outpatient appointment. 10,000 extras are carried out. 899 calls are responded to. 2,000 people receive treatment in A&E. I'm fiercely proud that our NHS has held in such high regard across the world. The many care that it is free at the point of delivery is something truly enviable and remarkable. It's a foundation of British society. A true national treasure which hides very clearly the values that we as a nation hold dear. And the heart of this are the 80,000 staff. Many from Europe and across the world who work tirelessly day in and day out. In one of 300 different roles within our NHS. They truly are NHS Wales's greatest asset and deserve our recognition and thanks. Doctors and dental teams. Nurses, paramedics and porters. Radiographers and receptionists. And all the others who make the NHS work. I'd like to thank each of you for your passion, your hard work and dedication. You all have an invaluable role to play in making the health service work. Delivering the high quality care that people deserve. In many areas we know that we're getting it right. We have high levels of patient satisfaction. So people who need the NHS feel that they are treated with dignity and respect. And they feel safe. We also know the service faces challenges. And there's always plenty of work to do to ensure that NHS Wales continues to perform long into the future. So happy birthday NHS. Another candle on the cake. As you get older you get stronger and more adaptable. And that's definitely something to celebrate.


Hello, everybody. I'm John Kadera. I'm an associate member, that's what they call an associate professor at the Memorial Stone Kettering Cancer Center. I'm one of the PIs for the open force field initiative, which is the NIH funded part of the effort. And I'm super thrilled to be here because like I can't tell you how spectacularly happy I am that OMSF has really taken off and to see both open free energy and open force field and all of these other things like open fold, nucleating and taking shape and having an opportunity to interact and create a wonderful interoperable ecosystem. So I wanted to start and talk about really two questions for so this should be a bit more discussion provoking at the end two questions for this group. One of which is well smirnoff is the world's number one vodka. Is it really the world's number one parameter assignment scheme and I'm going to at least describe highly experimental approach that we've taken funded by the NIH grant for open force field that you can download and use in a content package very shortly, but is going to be on the experimental side for a while and so we think about whether it makes sense in the mainstream mainline for open force field. And the other one is, are we really missing out on the advantages that machine learning frameworks afford for optimizing force fields, and we're thinking about force balance the major central part of our infrastructure right now it's now over 15 years old something like that maybe more. So we have a lot of opportunities that I think we can exploit we'll have a, an illustration of what that affords in the s below my toolkit. So, as all of you folks know here, the smirnoff specification or smirks native open force field specification, which is really borrowing the only the tagging from smirks into smarts describes not just a single Adam, but a bond or an angle or a torsion or any kind of balance type by assigning a whole smirks string where you've tagged the Adam that you're interested in or Adams that you're interested in this case is describing a bond that has a certain chemical environment it's an industry standard. It's really great it's allowed huge compression of the chemical perception from Adam types there's many advantages that David mobile has talked about in the past. But it does present these challenges and to be a gave a great talk as well as Trevor about ways in which we can think about this I'm just going to you know set the stage by saying, it is really difficult to optimize these types because of the fact that they are mixed continuous right continuous discrete. So we've got these discrete types and we have to keep refining them in some way where we think about like how detailed should we get before we distinguish one type from another type and trying to do this continuous and discrete optimization at the same time especially starting from scratch is just really difficult Josh fast in my group spent some time on this with a versatile jump to be a says really made a way to find a way to make this work. It's very well, but it's, it's difficult to get a good converged equilibrium sample from this joint space. It's just a really difficult problem mixed discrete continuous optimization. So you watching Wang in the group along with Josh fast had decided that maybe, you know everything else is continuously optimizable is there some way to make the typing continuously optimizable as well. Thought about, what if we had a embeddable way of saying how different every part of the molecule was from other similar parts and other molecules. And so they came up with this graph convolutional net. I apologize that launching wasn't able to give this talk remotely today or to be here. He wouldn't let him back in the country right away so thankfully they've now allowed him to come back and assume his fellow position at NYU where he's also a Schmidt fellow, starting his independent career. But he and Josh came up with this really fantastic idea that we can take up a chemical graph that represents a small molecule or big molecule, or, you know, a protein conjugated to a small molecule for example, and then using message passing graph neural to come up with a vector that represents every atom. And what's interesting about this is that we have to be very gingerly careful with the HDMI cable. But what's interesting about this is that you automatically get chemical equivalences because of the equivariance nature of this graph. So that means that if you have methyl protons, they're automatically assigned the same vectorial representation of what their chemical is. And if you have nitrogens that are in slightly different environments because they're in slightly different regions that have different things bonded near them, they'll get different types. And so we we solve this problem of having discrete typing. Next is, you can then propagate to bonds at angles and portions realizing that a torsion fed in IJKL is the same as LKJI. They have to get the same type. So we use this symmetry based cooling to make sure we get a vector that uniquely describes each bond, each angle, each torsion, each atom. And then you can feed these into just a feed for neural network that ends up meeting the parameters that you need for your force field. And by doing that, you make a very modular approach that is also fully end to end differentiable. So if we wanted to add for point polarizability, if we wanted to add special one for parameters we just take the appropriate type coming in from the stage two. And then we add on a neural network module to predict what the parameters are for that new type and then we just refit the model. And it's fully end to end differentiable. So it learns both the typing, the type assignment in stage one and the parameter prediction and interpolation in the final stage. And you can link it up to whatever likelihood functions you might want. So right now in the open force field force balance, we use both quantum chemical targets, which are various things that look at the loss or deviation from a quantum chemical property, like energies for confirmation, as well as physical properties like, you know, equilibrium densities or dielectric constants are possibly even free energies. So we're focusing now just as this proof of concept on quantum chemical confirmations and energies but I'll show you just as an example right this can actually recapitulate what we think about as typing so if we think about just the first stage and I'll take these embeddings and then cluster them into or put them into a bin, and just to assign, can I learn a gaffe atom type right. There's a bunch of gaffe atom types. There's a lot of them. In fact, there's a lot of carbons in particular, and it does miss assign some of these, but they're miss assigning in a way that I would have trouble assigning the specific ones if you gave me the description so in this case it's sometimes confusing NF with NC, which is a inner sp2 nitrogen and conjugated system, identical to any but in a not in a non pure aromatic system. So I wouldn't know exactly which one to assign in this case there's a few other cases that that are like this as well where the confusions mimic, perhaps the, the lack of crispness in the definition of chemical environments in these. Human like confusion in those, but rest assured if you give it gaffe energies or open force field energies, it can actually learn them quite well so now I'm showing it confirmations and asking it to learn the energies and in fact it recapitulates the bonds angles torsions etc. Very well from just showing it a force field so this is also in a way something that could help us take legacy force fields like a charm small molecule force field for example for which there's not a good free parameterization engine and learn how to apply charm like parameters if we wanted to. But what's really exciting is just showing it quantum chemical directly, like we do with force balance, and then having it learn the force field directly and I'm just going to walk you through a few experiments we did to try to understand how it works and what how it fails. So, Falcato is this wonderful set that Christopher Bailey put forward, because it's very exhaustively exploring the kinds of environments you might find. If you've, if you've enumerated pretty much all of the possible environments for a simple non complex carbon hydrogen oxygen system so it has fennels alkanes ethers and alcohols. And what's nice here is that so we've broken out, we have a training set, we have a test set from this space, and we're reporting here. All of these are test molecules on these other force fields so it seems to do in terms of rms error for these different confirmations error to quantum chemistry reasonably well in terms of K calls for mole. In fact it does a little bit better than open force field does in this pretty un complex case. These are 95% confidence intervals on the upper right and lower upper lower left, lower right and upper right. Now if we show it the training set for open force field 1.2. What's surprising is that it does much better on on the test set here than it does on the on open force field does on the training set so it's a diverse set of molecules but maybe this is suggesting that somehow by allowing us continuous interpolation between different specific types, rather than being pinned to specific smirnoff types, we're actually able to increase the accuracy over what open force field did on its own training set. This is something that we've been trying for a while with these vibrant bond order based interpolations there's good physical reasons why that should happen. And maybe this is allowing us to implicitly learn some of that and how to actually deploy it. We were also suggested by Katrina Meyer, the vehicle data set which is this really exhaustive exploration of bicycle bicyclic scaffold heterocyclic scaffolds of the future, which could be important for future compounds that might be. Give us slightly different bond vectors and slightly different polarities inside of binding sites, some of these look a little crazy obviously with the number of nitrogens you find in them, I wouldn't want to be caught dead anywhere near them because I might end up dead. But what was surprising is how much better as below my did in this case, then the open force field and in fact all the other models. The reason actually turns out to be quite simple so these were all subjected to QC fractal quantum chemical minimizations. And it turns out that some of these were not aromatic at all there was a cheminformatics error in their preparation, where they simply didn't satisfy aromaticity, and the quantum chemistry picked up on this and correctly made these weird nitrogen containing compounds appropriately pyramidal. And I don't know how realistic it would be for a synthetic chemist to access these scaffolds, but the fact that just by having a couple of examples sneak into the training set. Espeloma was able to pick on pick up on the fact that these should be different types, and then assign them different types was actually really heartening that suggests to us that it's really able. It gives us a new paradigm for solving the problem by just coming up with more examples, rather than having to have someone like Christopher help nominate new types. We can also show peptides, and it seems to do better than amber 14 sp does, which is terrifying, because a lot of time and effort has gone into parameterizing amber over the years and fixing a number of issues. We can in fact show it both peptides and small molecules and come up with a joint small molecule peptide force field so this is the first combined force fields that I think the effort produced until Chapin's new version comes out of a self consistent treatment, but it does seem to show stable simulations which is really impressive for something that is still using Leonard Jones and a and one BCC from open force field 1.2 in this case, but then just re typing all the valence terms now of course there's not a big opportunity for it to go off the rails right it's just learning the valence types in this case. What's really cool about this is that it does display the self self consistent size properties that you might expect. There's a certain limit to the number of rounds of message passing that you take. So you can't have effects from the ends extend far too far. So if you're looking at inserting different numbers of alanine inside of a cap alanine peptide, all of the online and all the charges, for example, as we plot here, all seem to stabilize after edge effects in position which may be realistic right and then seem to be pretty stable so that you can, you know, you can actually type full biocall race and actually very fast, there's some catastrophe here on the right side but you'll see that everything takes less than a second even up to 500 residues which is pretty impressive. And that's just on a CPU. In fact, you can take much less than that on a GPU. So you can actually use a GPU to assign parameters, perhaps for many things at once because you can bundle all of the graphs into a single large graph that doesn't have connections in it so if you need to parameterize many molecules. The really cool thing I thought was that who valent ligands are now breeze right by have a brute nib in its pre reacted form this is a covalent kindness inhibitor of BTK. It has this warhead over here that changes when it actually binds to the system here's the peptide part of BTK that gets changed by or labeled by this root nib. So you can see that if you it's hard to see with the small numbers here but you can take my word for it that there's some rearrangement and charges and bonds right around the reactive group, but the rest of the molecule remains unperture. So it doesn't do catastrophic things to your molecule. And in fact this will, we can also self consistently assign charges using the same kind of approach that Lily spoke about I think today, this morning, yesterday. We'll speak about did or will yes in the keynote. So what's cool here is that okay we use that this to apply small molecule parameters because we are now only only now thanks to the bio polymer support for PDV reading from open force field able to get the proteins in for into our tool chain for energy calculations. If you just replace the small molecule parameters, it seems to do reasonably well. It's very competitive with open force field 2.0, maybe slightly better, but it's hard to say. You need to try more systems to be able to say with certainty or confidence that it does, does any better than open force field 2.0 2.1. But the other cool thing is you can also propagate just like we see with other. We saw with host guest systems you can also propagate free energy so anything you can compute and differentiate you can also include as a target. And in fact the differentiation is automatic since we're using machine learning framework I'll get to that more in just a moment. I've mentioned the, there's, there's, there, there are potential advantages to using both the conformer energies and partial charges or potential ESPs in training a joint model because it seems that there's information content about learning about differences in in atom chemical environments by training everything together so you do see a reduction in error. If you train on both the energetics and the charges at the same time, because that's another important thing to keep in mind. I've already shown you stable simulations. So the next thing was, this was a very small training set. I believe we were limited in the size of the training set data initially for parsley because of the lack of scalability of force balance getting it to feed it many more quantum chemical data measurements. Also, we just didn't have a lot of data in QC fractal at the time that was appropriate. So as part of a collaboration between open force field and open, and open MM, I apologies I don't have all of the names here but you should go read the paper, or check out the data set for all of the folks that contributed it was a really a team effort generated a very large multimillion snapshot data set that has very good elemental coverage that provides us with information about the chemistry the chemical compounds that we have including their bonds that went into this so we can parameterize from that information. And he doesn't have any bond information which makes it a very difficult set to use plus it's also very limited in in elements. This set was generated with both a very high level of theory and a lower level of theory or the lower level of theory that open force field uses as its default specifications that be mixed and matched. This was generated slightly differently from what we've done with open force field in the past, because unlike the optimization data sets which are trajectories of optimization, or the torsion data sets and I should say that all of the data I've just shown you was just using optimization data sets we didn't even use any torsions, we seem to be able to recapitulate torsions reasonably well. If we do use that torsion data that's, that's great to we use every point along the minimization trajectory, however, for the optimization data set, but these are generated with MD simulations using, I think, either gaffer open force field I can recall which, and then using off equilibrium snapshots at slightly elevated temperature to get a better representation of what the energy surface might look like. Now Ken Takaba in the group has been working on extending this to nucleic acids as well. He's particularly interested in RNA you might note of notice that there's a huge number of companies that are interested in drugging RNA with small molecules or otherwise using them as a platform. I had some RNA injected into my arm maybe you did too. So suddenly become very important. Ken has worked with folks in the open force field side like Pavan and Trevor and David Donson to help generate a large RNA data set that supplements the spice data we can do the same with DNA at some point as well. And he's been collaborating with you on training on this updated data set that includes a subset of spice that is all of the open force field generation to optimization data. And then there's the base hub chem molecules which include a lot of different kinds of chemistries, both the dipeptides and monomers from the Desrez set, and the also the dipeptide, a dipeptide representative MD set, as well as the RNA data. And what's really interesting is that it seems it's very hard to see these numbers but it seems to be all existing force fields at least in this energy metric. So we hold out some of the data from each of these sets to leave us test set data hold out some of the molecules, and then we use that to estimate the test data set, which is also estimated for all of these other force fields so even for RNA force fields RNAOL3 for member, it seems to do very well for energetic properties. They're calling it spicy espeloma for this, but it'll be espeloma 0.3.0 or 0.4.0 depending upon where they settle is already a pre release available. I'll talk about that in a moment. Thanks to David Mobley helping us work with Pavan. We've gone through several iterations of benchmarking and identifying limitations and failures and improving things like how we treat the improper torsions. It turns out we were trying to predict too many improper torsions and there are still many things that can be refined with this perception approach about how we assign torsions because we we let it assign any sign to the case. So you can get the phase as a continuous parameter from one n equals one all the way through n equals six periodicity to torsion so we've had to trim that a little to do what open force field does to limit it to one or n equals one or n equals two firm properties, but it does seem that the quality these quality metrics are suggesting that it's doing very well on this industry nominated benchmark set. It also seems to be doing reasonably well on free energy calculations again, rivaling the open force field 2.0 in accuracy will have to see how that works, how that plays out for many more, many more sets. Okay, so that's the first question or proposal is that I think this might be a competitive way of solving these challenges in mixed continuous discrete optimization. And that's something that that we could we can investigate as a potentially forward in parallel to Smirnoff for a while but possibly to replace it sometime in the future. The other thing is, I wanted to engage with you about how useful it has been to use these machine learning frameworks there's a lot of effort behind these a lot of folks are using them. This is now a very old example but it shows you just how exciting it is to have, you know, somebody has curated a standardized data set like the open force field has and you can access that programmatically in one line. You have a novel architecture that you can define which might be a completely new type of architecture using powerful abstractions that thanks to the toolkit writers, you can compose very easily. And then using best practices standard best practices you can optimize it assess how well it's doing and then actually use it just in a few lines of code. And we can do similar things with force fields if we really really wanted to. This is not a working example but certainly the inspiration for what we'd like to do what if I just comment out the bond charge corrections or add in a point polarizability or add in a special one for exception and then refit and then do these experiments very easily. This is a working example of that realization this is fitting an entire force field in espeloma. It's very easy. It's also very easy to extend because I just need to add a few more lines to express whatever energy functions I want to implement. It makes force field science very easy in terms of exploring different models, at least if you're doing fitting to quantum chemistry takes more effort of course to fit to experimental data. Now, these machine learning frameworks are great because first of all, another major major companies are pouring money into maintaining them so we don't have to that relieves us of some infrastructure burden right we have to maintain, along with the The other thing is hardware acceleration is baked into these machine learning learning frameworks and they're always investing in making them faster. We could build force fields on GPUs as a result. They're scalable these force field these frameworks have scaled some of the largest hardware installations available, probably much larger than we have access to. There's a lot of libraries of optimizers or Bayesian samplers or tools for tracking the experiments that you run, like weights and biases. There's also a lot of support, there's many people using this compared to the number of people using force balance. So, there are two experimental versions of espeloma available right now. They're almost condit installable. Right now we're working on one of the tool chain issues I'll get to in just a moment. One is a pytorch based version, and the other is a jackspace version, the pytorch one is much more mature the jacks is even more doubly experimental, but they fundamentally do the same thing. It's an exciting approach because I think many of you know pytorch but jacks is combining Python with autograd, and then the Google based back end that TensorFlow uses called XLA, which translates code that's been compiled just in time to run very fast on hardware like a GPU or a TPU or a CPU or any new hardware that comes along that you might want to actually take advantage of somebody else is going to take advantage. I was going to figure out how to do that quickly, and it just is Python with four superpowers one of them is jit which is make it fast, you can wrap any function in that rad which is give me the gradient with respect to parameters or whatever. P map which is do it in parallel on the GPU or TPU, and then P map is do it in parallel across many nodes and you can combine them in any way you want. And it's been the ML choice of deep mind for a long time and likely will replace TensorFlow at Google if things keep going the way they're going. So if we think about what impact this would have for our communities right the scientists might be able to rapidly carry out faster refitting experiments if they could fit with the GPU. And it's much easier to explore new potential terms because it's much easier to code one of those up than the whole plug in that takes advantage of something in OpenMM. They can experiment with these potential with ML potentials as well because they're all written for these frameworks and not for OpenMM can simultaneously build and assess both Smirnoff and Espeloma style force fields would be the dream so you can optimize parameters fixed Espeloma types or you can optimize an entire Espeloma set or you can even build these Bayesian ensembles and explore Bayesian force field parameters of families for the engineers who have to do this for big fits, it would be fast and scalable and reproducible. And for industry, I'd like to think about this paradigm, you know, could we make it easy enough for people to use an industry that we are producing the foundation models that people take home and tailor to the data sets and problems they have internally. This could be a new paradigm for industry to really rapidly fine tune and get better results out of our force fields for the problems that they care about. And we haven't focused on making it easy to use for industry yet it's possible, but if we were able to do that it would be much easier with these deployable machine learning frameworks. And there's a few opportunities as well and about how we could how we could overcome some issues to make this better one of which is that we can use our existing tools like the property calculator that Simon and others have engineered for computing free energies and gradients. A lot of it is setting up workflows to build these systems and simulate them in a way that is automatable. But at some point we can integrate these ML implementations of the energy functions to evaluate the gradients much more efficiently. We can also potentially ultimately replace the open MM layer with a ML based simulation engine if one comes along. There's a few experimental ones like torch MD, and a few others at the moment but this might be something that is also an opportunity in the future to let us take better advantage of these big GPUs which waste a lot of time by simulating a very tiny system pack them all together. David's Rudy of course has another way to do that but this would be one one possible alternative. And of course condo packaging is a challenge because this community has standardized on tip. Now, that's a discussion that we can have that's much larger but there's a lot of opportunity for us to help work with these communities and get all of their tools on to condo as well. We've managed to do this for everything except DGL which is the final piece because it has lots of dependencies that have been pulled in. So we're almost there and Mike, Mike Henry has been really pushing this forward so we're almost to the point where you can install it like Honda, you can very easily install it other ways though. And so, for if there's any time left, I'd also be interested in what folks think about, you know, we do have some opportunities and we have to figure some things out one of them is this benchmarking suite that was announced yesterday is going to be really exciting with the modules that allows to plug in different ways to compute data and compare against it the same modules are used here to parameterize and we would want to compute ratings of them so there's an opportunity to avoid duplicating our work by architecting these properly so that they can go into either framework perhaps. We also want to think about what is the MVP what minimum functionality would we need in order to be able to swap out force balance at least for some tasks would it be interesting. We could try the industry tailoring, for example, where you they can easily generate quantum chemical data or any like data that they can use to tailor their quantum chemical to generate quantum chemical data sets to tailor just the balance, but stick to our non bonded for example that could be an easy win, would it be really useful to do balance fitting to quantum chemistry for the scientists for force open force field to be able to try out new functional forms very easily. And we have to think about what that MVP is and then is there a path to deprecating force balance is it something that we want to keep alive all the time we don't want to have to support two different routes to do something forever, but there might be some sort of sensible rap to thinking about sunsetting it in the future. And with that, I'd like to thank all of you for your attention and if you had any thoughts on the discussion questions I'd welcome them during the questions.


What's up internet? You're viewing yet another Asurix card na katatlo na kami. But before we get to this specific card, pagusapan muna natin yung Asurix in general. Kasi andami nang tatanong online, dami nang mga flame wars, dami nang nagagalit. May nagsasabi na scam yung Asurix, may nagsasabi na de-legit naman sila. So ano ba yung position namin? And to be honest, when we get Asurix cards, kinakaban ako. Parang iningisip ko, kinatay ako ba yung good reputation of the shop, of the channel, on a brand na we don't even carry, we don't even sell Asurix in the shop. But all we can say is based on our experience, legit naman sila. The cards are what they claim to be. Kung binilimo RX 580, RX 580 talaga yun. 5500 XT, 5500 XT talaga yun. The chips that they claim are in the cards are actually those chips. And the price is good. Compared to comparable cards on the market, the Asurix price is significantly cheaper. And we did have one comment in one of our Asurix videos explaining na nasirayong card niya at pinawarantin niya. And overall, mukhang okay naman yung experience. Na tagala naman konte, pero legit naman. Tinulungan siya ni Asurix and eventually they sent him a replacement card. Yung hindi lang talaga namin masagot is longevity. We haven't had these cards for a long time. The oldest is only several months with us. Pero ginagamit talaga namin sa shop either for the personal use of our staff, pag of hours, or sa mga test bench namin, in rotation talaga yung mga Asurix cards. Because one of the advantages is you don't really need to power them. They're not very power hungry. They're easy to swap out. So we have been using them so far. Nothing to report. They're all still working. Wala naman failures. Wala naman weird behavior. But so far, so good. Sa waka na ba sa unactivated windows mo? Well, lucky you! Pinakamago mula sa silikioffice.com. Windows 10 and Windows 11 activation codes. Legit, safe, and pinakamura. Madadilo mo order. Hanapin ang windows version na gusto mo. Piliin ang preferred paper and pencil. Wala pang 5 minutes na sisi gika na para sa windows mo. Maramin na kaming na tunungan. Date? Sa'kin di purchase ako. But now, I found a log of my life. Date? Ing-less ang walang purchase ang life ko. But now, I'm a world class Zumba instructor. So web developer ako and content creator for a YouTube channel. And ngayon ganun pa rin ako, pero activated na yung windows ko. Kaya ako naghanap ka ng legit, mura, at original software. Check out CDKoffer.com. Check out CDKoffer.com. Check out CDKoffer.com. And with that, we go on to the latest card na pinadala RX 580. Pero tega, RX 580 ulit. The first ASURX card we got was also an RX 580. But ito yung pinakalates nila. Pinakalates daw na updated yung cooling. So they've changed the heat sink a bit. They've changed the cooling element. May backplate na siya. So the RX 580 is anong quantity. Basically, you can look up online what games go well with it, 1080p settings, very decent performance even now in 2023. So just a specific question about this latest card. Does the improvement in cooling make any difference? Dadagdag ba yung performance mo sa games? Because it runs cooler. And that's what we'll find out in this video. We tested both the old and new versions of the ASURX RX 580. And to get the temps as hot as possible, our test setup for both was a really tiny SFFPC. In Forza 5, medium preset, the old card had its lowest FPS output at 51, compared with 52 for the new card. Max FPS on the old card was 80, whereas it was 82 for the new card. Finally, average FPS of the old card was 64, with a new card at 65 FPS. Temps-wise, the average temp of the old card during the Forza test was 63 degrees, compared to 61 degrees for the new card. In Shadow of the Tomb Raider, high preset, the old card had its lowest FPS output at 50, compared to 51 for the new card. Max FPS of the old card hit 96, whereas the new card hit 100 FPS. Average FPS for the old card was 62, with the new card edging it out again with 64 FPS. Temps-wise, the average temp of the old card while playing Shadow of the Tomb Raider was 62 degrees, with the average temp of the new card just a shade lower at 61 degrees. Finally, we also ran 3D Mark. Floor FPS for the old card was 14, with 15 FPS for the new card. Max FPS produced by the old card was 50, equal to the new card, which also hit a max FPS of 50. For average FPS, though, the old card managed 24, and the new card edged it out again with 26 FPS. Temps-wise, the average temp of the old card during 3D Mark was 55, whereas the average temp of the new card was 58 degrees. The only time that the new card had an average temp higher than the old card. Bottom line, mas maganda ba tong bagong RX 580 compared to the old one? Impressively, may increase nga talaga sa frames per second and mas malamig nga siya. But looking up the data, sobrang liit lang ng performance game niya. We're talking about like 1 or 2 FPS. Qualitatively, hindi mo mong kapansin yun. When you're playing a game, 1 to 2 FPS increase won't really matter. And that's the same thing with a 1 degree difference. Yes, mas maganda na mas malamig siya, but at the end of the day, nothing will really change with a 1 degree difference. Pero, baka na ba pinag-usapan natin? The new RX 580 currently sells for around 4,360 doon sa Isurix na Shopee site and the old one goes for around 4,200. So we're talking about a 160 pesos difference. Kung yun lang naman yung price difference, wag mo napag-isipan pa. Yes, you probably won't feel the difference but there is a difference measurably. Kunin mo na yung bagong RX 580. If you're still on the fence, which card you should get, the old one or the new one? 160 pesos relatively isn't a lot but at least may gain talaga. Thanks for watching. Paming saan may nagtatanong kumikilala ba kaming computer shop na trusted yung hindi kalolo ko hin? Actually, meron kami. Full service PC store ang hardware sugar. Nagbabenta kami ng PC components. Nagbabenta rin kami ng fully assembled rigs. May clean computers. Kasama na rin yung excellent cable management namin and CPU cooler repasting sa cleaning. We also clean and repaste GPUs. Nasamakati yung physical store namin and you can also buy from our site, www.hwsugar.ph na 100% palaging up-to-date yung inventory dun. Kung instock yung item sa amin, available yun sa site. We also ship nationwide. Thanks for watching and maybe one of these days, magkita tayo sa shop.


Representation politics in the common view, political representation is assumed to refer only to the political activities undertaken, in representative democracies, by citizens elected to political office on behalf of their fellow citizens who do not hold political office. However, the lack of consensus in the political literature on political representation belies this common view. Theorists of representation differ not only in their definition of representation but also, among other things, on what the beauties of a representative are, who can't be called representative and how one becomes a representative. In her seminal work on political representation the concept of representation and a kit can define political representation as, the way to make the represented present again and identified for views of political representation which, since her book's publication, have shaped contemporary debates on political representation. Recently, Jane Mann's Bridge has identified for other views of specifically democratic political representation which, although they are distinct, share some similarities with Kitkin's. On the other hand, Andrew Refelt has critiqued the failure of theorists like Kitkin and Mann's Bridge to articulate the purely descriptive view of political representation and has proposed the general theory of representation that recognizes that political representation can be and often is undemocratic.