So that's Matt's worst and Michael's worst would probably be, I shower more now. Yeah, his hygiene's definitely gotten better. I think Amber's done that. Yeah, I don't know. I'll have to think about it. I'm eating better. You've been eating better for a while though. I cough up some phlegm still. That's just from smoking. He is. That's real phlegm. Oh, that is fucked.    It's speaking to you. I don't know if the wide camera can get this in. It's speaking. You might have to get up. Gollied on the table and Matt is playing and you are coming your way. You got a new worst habit. Okay, so I hope I can see you. Yeah, I got a new worst habit. Matt, he doesn't like snail. Looks like a snail.  What's your? What's your?  Oh, my God, no, no, no, no, no, come on.    You've got to go like this. Oh, my God, stop picking it up.  Man. Fuck. Oh, I don't think they saw it though. It's a fine feeling. It'll get deleted.  I cut that table out whenever I think I thought we were on. It's all right. It doesn't need to be in shot. Shall we get another one? No. Come now. What's worse, blood or mucus? Oh, definitely that.  Sorry. Looks like it. No.  Anyway, Marty, what's your worst habit? It's stem cell. Can you tell me what is my worst habit? Oh, um, um, my lack of sleep. Yeah. My inclination to smoke weed. No, I reckon like, because it makes it funnier. I reckon, oh, worst habit. I guess you give into the sugar. You give into the sugar too. Yeah, but not. Oh, I've seen you cookie. My self-control isn't the best. Yeah. That's not a worse habit.  Oh, yeah. I don't even know what's about it. Oh, road rage. Yes.  I used to, I look, I used to get bad driving. But no, come on. It's just fast. It's just a bit quicker than usual. Oh, no. I remember like driving into the valley with you and you were so enraged by someone you accelerated through a red line. It went red and you went, no. Straight through it. I was like, that's not. I don't feel safe. That would get so uncomfortable. Yeah, Matt won't drive in the car normally if Marty's driving. He's still like, that's hilarious. Some driver's just like, fucking, got to get there. Got to get it done, done. But no, I think my road rage has definitely cooled down heaps in the last three years. For sure, I would say. Maybe every now and then it's still have a little fucking. Oh, I agree. I get angry. Some people are so slow. Yeah, some people deserve it.  Just stay at home. You can't drive the speed limit. If you're too scared, there's something wrong and the world has developed more than you have. And you need to stay at home and deal with it. If you're going like 20 under. I don't want to be an extra 10 seconds late. All right, and that's questions. What other? Have we forgotten a segment or something? No, lying to lucky. Oh, yeah, lying to lucky. He's in Dubai. Yeah. We can't. I call. It works. Let's ring him then.  All right. What should we lie to him about? How can we say that? He's not in Dubai. I reckon he'll know that pretty quick. Just look at his window and see that he is. Good to know that he did that. What are we saying to him? Mom's dead. We'll just keep saying that the contract's fallen through. We'll tell him that he's mom. The contract's fallen through. We could say. We could tell him that we've. Tell him you bought Jackson's house. You were a secret buyer.  Like Jackson's hurt himself. What if he's like right there? That's why it's funny. Yeah, we'll be like, dude. Jackson's just DM'd us and he's like, hurt himself pretty bad.  Like, yeah, it's not funny enough to know straight away. What's something that? Oh, he's going to know anything we say to him now. Why don't we say Andy Lee won the Golden Logie? Yeah. All right. Does he know what the loggies are? Yeah, sure. Surely he does because Hamish won it, didn't he? Yeah, Hamish won. So I'll say Andy beat Hamish in the Golden Logies. Okay. All right. I'll say Jackson's been injured. Okay. If the gold loggies doesn't work, yeah, that's our plan B lie. Yeah. If anyone overseas, the loggies is an Australian TV award. It's like the Emmys. Yeah. But for Australia. That's exactly what it's like. And it's, yeah.  We're calling a lot. This is a segment where we just call Loki every week and just lie to him and see if he believes it. Anyway, here we go. Sorry. Sorry. Fuck.  All right. And that's killed that. Should we cut that? Yeah. Maybe cut that. Well, up to you Connor. Me up to you Connor. No, no, no. Let's leave it in. Let's leave it in. And people, if you have comment what lies you want us to tell Loki. All right.  Yeah, we'll do that. Do you want me to pick up there for like six months? No, no, no. Okay. All right. Yeah. All right. Next segment. The next segment. Hey, before we get there. What do you think of this comment? Here we go. Jet Greg Star. Now, I thought this comment was actually pretty good. And I've only just realized that it was there. But remember how you guys said Jet Star was shit? Yeah.  Jet Greg Star. Oh, that's the comment. That's the comment I should have chose. Yeah. So I'm sorry. That was Rob's trains. I feel like we should kind of put him up there. That's not a bad Greg. Greg Matt. Greg Matt. I see a lot of Greg Matt. Yeah, that's a lot. They're good. They're coming out. Brown. Woodworks. Yeah. Greg Brown. Matt. Greg. Yeah. Good. Greg Matt Brown. Greg. Greg Matt. Brown. You can. Yeah. It's great. Anyway. god knows what this is. And Greg, Scissors always disappear. I found scissors the other day. Anyway, we'll open this one first. Hey, I'm opening this first package. It just says Marty and Michael fully actual on the front. That's exciting. It's a side. I don't know. I'm scared to I always get scared to push it. Oh, no.  Oh, I don't trust it. The what? I don't know. I just don't like the wrapping.  Is that good? All right. There's nothing in here. Is this just a vacuum? Oh, this doesn't look good. OK, so I pull out another package. It's sticky. It could be flim. It's sticky. It says a package in a package. Can you open that? I'm so. Why did you do that? I don't know. Oh, Michael's opened his box at the same time. I think that's safe. Michael, I think I know what it is. So I got pre. All right, Michael's box is nearly open. There's some sort of black thing in there. What is it? It's like wrapping read the letter. Big love. Oh, no. What is it, Matt? What's in the back and canister?   All right, Matt, pull it out. Let's see what we got.  Oh, no. All right, we've got some leather. Is this from Haley? Yeah, yeah. This is the leather, the leather girl. And she gave me some instructions and I forgot. Oh, no. She she asked me to let her know. All right, let's see what that is first.  Oh, oh, you might like this. If this is what it says on the front, it says it's dried cannabis.  It's not open.  Is this medical marijuana? Some cool belts. Twenty-one. That's a medical marijuana calendar. No way. Thank you, Haley. Careful, it could be a trap. It's not. Oh, smell. It is. Wow. Smell of that. Someone just sent us medical grade. How did that get through the mail? That's incredible. And there's a letter in here with it. We'll open this first and we'll get to Haley. All right, here's the letter.   How was it?  He is. There's more. Yeah, but no, yeah.  Can't say Matt Brown's a star.   We get the best of the Secret Society. And after all, I am the man.  Love MML of Secret Society.      That's good. Great. All right. Now, Haley has we've received a package from Haley. It's leather and Michael. I had to guess your measurements, by the way.  Oh, they're like these are these are things you wear. They're suspended. Yeah, these are suspenders. I had to give them the measurements and I guessed. So hopefully they fit. So Haley's a belt for Maros. Like it feels real nice.  And the feel of that. She's got a website. She's in Tasmania. Is that right?  So never you never get it. This is a good quality belt. I'll take it. No, I myself do not like some of the things those boys do on their website. They're twirling habits. For example, they really turned a new page of gross. I'll admit it. But come on, Mr. Be a part of the family and subscribe for fuck's sake. Anyway, what that says. Anyway, I design and craft. Listen, this is she's given us these gifts. Anyway, I design and craft these pieces for my business. H M J M I E N H M J. Me and they are made with solid brass and stainless steel, as well as top quality, ethically sourced leathers. Marty, that belt will last lifetimes. There is no glue or stitching. You just shot. Just solid Chicago screws for your subscribers. I have a discount code fully actual 20 in capital letters for 20 percent off all of her products. My website is H M J M I E N dot com. OK, H M J M I E N dot com. So go there fully actual 20 capital letters for 20 percent off.  Thank you very much, Haley. Thank you, Haley. I need like a good belt. I never buy a good belt. Some good box.  Don't touch that. You're allowed to touch this. OK. Yeah, look, she sent this one for you. It's a little key chain, Matt. And it says, nice.  You put it in it. So you read behind.  And it is prank call time. He says, yeah, what the fuck? What are we going to do again? Hello, my name is Arnold Fan. OK, I come yesterday to buy a foot phone calls and I buy some milk. I buy a noodle, maybe some tomato. I give to my pick at home. My pet to pick. And now my pick is very sick. You vomit through the kitchen and my wife slip on the floor. She's sick, flicking around. So your food make my pig sick. Your food make my pig sicker.  Sorry, what were you sorry? Couldn't have called you then. Could you repeat that place? OK, OK, you listen. I talk for a long time and you listen. OK, I come in your shop yesterday. OK, I buy some food, noodle, tomato, milk. I buy two, three milk. I feed to my pig, my pet pig at home. And the noodle and the milk, it vomited all back up.  OK, have you got the item still? Have you got the receipt? Maybe receipts I look for. But my pick is vomit on the floor. It is slip around and flick and the roll from kitchen to lounge room. Vomit flick on ceiling. Pick look confused. OK, have you still got the bottle? Have you still got the bottle? I don't need the actual milk. I need the bottle. Have you got that? The milk I have to do a product, like a product complaint form and give you the refund for that one. If you've got the bottle, you can put it up and get the receipt and the report of the receipt. The milk, two, three dollars, no bigger problem. But my pick is sick. OK, I vomit in front of me. My wife screamed at me.  And my pick are flicking around. I need to take to vet.  My vet bill will be a hand rat. Hand rat, she's just been hit by rubles. Yep, yep, OK, all right. Sorry, I'm going to put you through the duty because it actually sounds serious. Please sign the line, please. Please sign the line, please sign the line. OK, OK, huh? Thank you for calling Cole. It's OK, I'm out of... Oh, they're not a person. Please sign the line, please sign the line. Did you know at Cole?  Please sign the line, please sign the line.  Please sign the line, please sign the line. Talk it to me, yeah? I talk it to you. Because it's important...  Bitch! ...providing our customers with Australian food. I find you, huh? I find you, huh? Fish, milk, and noodle.  We'll be with you soon. Mmm... At Cole's, we know... ...more talk-a-talk-a... ...from. That's why all of our Cole's brand Mmm... ...is sourced from Australian... That's a person, huh? Okay, hello. Sorry to keep you waiting. All right, so I've had a quick talk of the duty just about this situation. Okay. Yeah, yeah.  We need to launch a product complaint form. Basically, you know, they'll escalate it up the chain and they'll be able to handle it from there. Basically, any sort of thing. I totally agree that, you know, that what's happened is an unfortunate situation and it should not have happened, but we'll be able to get through this, okay? I do not know if I find the bottle. Okay, I look through bin, but my pick is a vomit. The vomit on the floor, after the noodle, I gave the pig noodle and the vomit in the kitchen. Who clean mess, huh? May I come pick up your stuff and bring them over to clean? Yeah, but I understand if you can try and find that bottle, it would be great when we can launch a product complaint form, all right? Just come to the store whenever you can, okay? Wait a minute, but who clean my house? I have a pick of vomit, a flick on the ceiling, and a flick on the TV, and a flick on the floor. Vomit all over the place, I need someone to come clean.  I'm sorry about that one. We'll see what we can do, okay? No, I'm sorry.  I come and pick you up to bring to clean my house, huh? You clean my house!  Oh, dude. That was one of my favourites. That Arnold's fine, it's so beautiful. Oh my God. Whoa. He's getting so feisty. Yeah, yeah, he doesn't have time for people's shit, plus his wife has been sick for a very long time with alcoholism. That was very good. The reason I said don't say anything on the hold, I listened to phone calls the other day on our phone system and we could hear the hold music, but at the same time, you could hear the guy in the background going fucking, motherfuckers, they pissed off.   Yeah, that's what we want because he can, oh no, he broke character. And I was like, fuck, don't break character, yeah. But I don't think that, yeah, hopefully they didn't hear that. I don't think they did.  They're like, sort of, the first chick was pissing herself laughing. Yeah, she was like, oh, was she? Yeah, she had it over, she's laughing in the background. She's like, I don't think I can handle this. Yeah, I couldn't do that. Really? Yeah.  No, he's fucked. Oh, all right, guys, that is the end of episode number, is it all over? Don't forget to subscribe, episode number nine, and you get your chair next week, in your chair. Is it good? Anyway, don't forget to subscribe, like, and comment if you had a good time here today, and we'll be back next week because we are the best. The best. We're the best. We're the best. We're the best. We're the best. We're the best. We're the best. We're the best. We're the best. Best.  This is what I really look like. We're the best.


Here, everybody, Dr. O. This video we're going to talk about the polymixin antibiotics. I think this is a very important video. I'd like to think that I don't make a video that isn't important. It's the stuff that I want you to learn. But polymixin, you're going to see why in just a little bit, it's super, super important. So let's start by just talking about how they work. So I'll just read through here. It interacts with the lipopolysaccharide in the outer membrane of gram-negative bacteria, killing the cells through eventual disruption of the outer membrane and cytoplasmic membrane. We see there is the outer membrane, meaning these drugs are going to be very important for gram-negative bacteria. And the reason that's important is because most of the drug-resistant strains were concerned about are gram-negative. At this point, about 95% of research funding is going towards dealing with gram-negative bacteria. And I covered that in the cell wall video, the cell, you know, the gram-negative versus gram-positive video. The reasons why gram-negatives are generally more dangerous, right? Some drugs can't get inside of them. Some can be pumped out of them in ways they can't against gram-positives, etc., etc. So they are the scariest of the organisms. There are some gram-positives out there that do tons of damage. But if you can create an antibiotic that can impact these drug-resistant gram-negatives, that's going to have the potential to really help us as a species. So let's just talk about polymix and B first. So they were first discovered in the 40s, lack lots of them. Isn't it crazy to think how many antibiotics were discovered way back then? Or not seeing them discovered at the same rate? I always like to say that the low-hanging fruits are already been picked. There hasn't been like new classes of antibiotics in a long time. So we need to do something. We need to come up with something to stay one step ahead of these microbes. So they were discovered in 1947. So it would have been basillus, basillus polymixin. So polymixin B and polymixin E, which you'll hear called colistin way more often, are the two that we're going to talk about. So polymixin B, the problem is these antibiotics disrupt cell membranes. So we want them to destroy the outer membrane of gram-negative bacteria, but like it says, there can also impact the cytoplasmic membrane, the cell membrane or plasma membrane, which we have. So this is not an example of a selectively toxic drug, because it can impact our cell membranes. So polymixin B and polymixin E, they both can affect the cell membranes of kidney cells. They're not toxic, but also the nervous system. But that's why polymixin B is really only used topically in triple antibiotic or other preparations. So triple antibiotic, you've got neosporin, which would have neomycin, bacitracin, and now polymixin B. So those are going to be the three antibiotics that make up your neosporin or triple antibiotic. When is this especially effective? It is still, you know, polymixin antibiotics are still very effective against pseudomonas. Let's go ahead and move on and talk about colistin or polymixin E. There's a little bit of a history lesson here as well. So the polymixin antibiotics have been around for a long time. At one point, colistin was being used, but they realized that it was especially nephrotoxic. It was damaged into the kidneys, so they quit using colistin, except for some limited uses. So it's absorbed poorly. It causes kidney damage. So primarily, I'll read here when it was primarily being used, oral dosing to decontaminate the bowels to prevent infection in immunocompromised patients or patients undergoing invasive surgery slash procedures. So what that means is, since it isn't absorbed very well and can kill the gram-negative bacteria living in the gut, they would use it just to massively bring down the population of gram-negative bacteria in the gut. That's what a bowel decontamination is if there was concerns of these organisms causing an infection, killing a patient, getting into the body. So that was primarily what it was being used for, but it really wasn't being used much clinically. So since it wasn't being used clinically and for very limited uses, it started to be used agriculturally. So colistin has been used especially in pork production, so like in pig farms in China, they've used thousands of pounds of this antibiotic. And then it wasn't being used for humans, so it had this agricultural use. Well, in 2015 is when they first found signs of colistin-resistant organisms on these pig farms in China primarily. Rather than because the world has shrunk down because of travel and food and people moving and bringing organisms with them and the rapid evolution of these organisms. By 2017, we're already seeing relatively serious problems or at least an increase in colistin-resistant organisms in patients in the United States. So think about how quickly things can evolve and change from not being a problem, to resistance on pig farms in China, to resistance in humans in America in just a couple of years. In 2016, there was a handful of cases, but they all lived in, they were all compromised people living in long-term care facilities, but now you're talking about relatively healthy people. So this is a problem, and the reason this is a problem I've talked about in a different video is if the CRE organisms, the carbapenem-resistant anterior bacteria C, which can already resist all of the beta-lactam antibiotics, if they also become colistin-resistant, we will have Pseudomonas, Klebselonamonia, Shigella, E. coli. We will have members of this family of bacteria that we don't have treatments for, like truly untreatable bacteria with our current antibiotics.  That's why I wanted to talk about this history part of it because it's been around a long time, but you're seeing the rapid resistance now because it's agricultural uses, but then it is being used and has been used for a while. So the main reason colistin is important is right now it is the last line of defense against these CREs, which are superbug infections, meaning they're multi-drug resistant. So let's talk about the intravenous uses then. So oral was just for valedict contamination because it isn't absorbed well through the gut anyway. Intravenous dosing to treat serious systemic infections, primarily these CRE drug-resistant superbugs, caused by multi-drug-resistant pathogens. So it's been used in that way since the 90s, but it was just used a little bit and now you're seeing it used more and more. It was primarily used when they first started to reuse this or reintroduce this into treating humans. It was used with children with cystic fibrosis that had pseudomonas infections. So I mentioned in other videos why pseudomonas is a big problem with CF patients. But we're now relying on this drug to be our last line of defense against these CRE organisms, carbapenem-resistant anterior bacteriose. They are some of these, like if you have a CRE infection with treatment, half the people in the blood, if the infection gets to the blood half the people are still going to die. So we are running out of antibiotics to fight this group. That's why if you went to Google right now and typed in nightmare bug, nightmare bacteria, chances are you're going to see one of the CREs. All right. So these are your polymixin antibiotics, polymixin B is just used topically in the triple antibiotic ointments and it's good against CREs, just like polymixin E is. But this one, this is the antibiotic out of all of them that I'm paying the most attention to because if this antibiotic stops working, we are in a much more serious situation than we already are now, which we already have tens of thousands of people dying from drug-resistant infections. So I definitely don't want to see this get any worse. I hope this helps. Good luck sleeping tonight. Have a wonderful day. Be blessed.


Ukrainian President Volodymyr Zelensky thanked Denmark for military support to Ukraine in a speech he delivered to parliament in Copenhagen on August 21. Zelensky and First Lady Alina Zelenska were greeted with a standing ovation by Danish lawmakers. Russia has condemned a decision by Denmark and the Netherlands announced on Sunday to donate F-16 fighter jets to Ukraine, saying the move would escalate the conflict. The first six are due to be delivered around New Year. Denmark will deliver 19 jets in total. Zelensky called the decision a breakthrough agreement and said the planes would help strengthen Ukraine's air defenses and help its counter-offensive against Russia's 2022 invasion. Russian evil strikes with pain and death at Ukrainian cities and villages, but they openly say that Ukraine is not enough. Later, after our country, they want to carry the suffering further to Europe and to the world. And I'm sure you hear it, you hear it from Moscow. All of Russia's neighbors are under threat. If Ukraine does not prevail, international law will not be resuscitated. The democracies of the world, each of them can become a target, either for missiles or for mercenaries or for destabilization, and I'm sure you can feel it. But Ukraine will prevail. When Putin ordered this invasion, he only believed in the lens of his armed vehicles column. In power of explosions of Russian missiles, he believed that cruelty is capable of rewriting the history of an entire continent, erasing this history, pushing it back a century, yes, to crush everything that makes our continent and our country peaceful. He believed only in force, in force without humanity. He trusted violence, and that is why he is weak. We believe in something completely different, and that is why we become stronger, all of us, together with you. Thank you for your help, help provided to Ukraine. Thank you for hapuns. I am sure you will not be afraid of it. Thank you, scissors, lap hearts, breadless drones, yes, they afraid drones, and artillery. And thank you, thank you for demanding machines. All this serves freedom. in this very moment, so as to protect people's lives.


How can I manage my Moodle site? When you first log into Moodle as a new administrator, look for the link site administration on the left in what is called the navigation drawer. When you click it, it will display the site admin area of Moodle accessible only to administrators. You can collapse the navigation drawer by clicking the hamburger icon to free up space and you can expand it again by clicking once more. Each of these tabs represents an admin area of Moodle. Some of them allow you to manage default settings for teachers and students. Some of them allow you to specify advanced settings. There are too many to consider in one short video, so we'll just have a quick overview. If you need to define something quickly, use the admin search. For example, if I want to view or change the password policy, I can use the search to locate parts of Moodle where this applies, in particular the site security settings. From the first tab, notifications is where you can see your version of Moodle and registration is where you go to register your site. From advanced features, you can turn on or off some items which you might not need. Along with settings which we explore in other videos, you can also access here messaging and Moodle app settings and add and specify languages you want your site to display. You will probably get to know the users and courses tabs very well, and if you want to manage how grades display and work in Moodle, you do it from the grades tab. From the plugins tab, you can see the elements of your site, modules which plug into it to help it work better. Some plugins come as standard. Others can be installed by you if you're hosting allows to add a lot more functionality to your site. Note it's not possible to install plugins on Moodle cloud sites. From the appearance tab, you can customize the look and feel of your site, for example with themes. Server and development give useful technical information about your site and from the reports tab, you can access useful logs and other site data. If it isn't there already, you can add an admin bookmark block by clicking the button blocks editing on and then from add a block on the left, select admin bookmarks. Configure it to any site administration page and then whenever you come to a page you wish to bookmark, you can do so and have quick access to it next time as we're doing here with a theme settings page, for example. To summarize, the site administration tabs group important admin areas. Admin search helps you easily locate items. Admin bookmarks allows you to save useful pages for quick access.