It's the breakfast and plus TV Africa. It's time for us to go through the papers We call it off the press to the color. Well, he joins us at no time We set up with this day newspaper that's been made available by paper vendor You can't abandon work for election campaign. Buhari wants says Penalty awaits violators or order of the order and directs SGF ministers to prepare Transition documents signs executive order 12 to institutionalize accountability and transparency INAC chair expresses concern over attack on PDP rally in Kaduna says it has reduced Essence of peace accord house minority situation room worried and demand probe Just before we move away floods build dams desealed major rivers or core Urges the federal government Diri six federal government supports direct workers to go on one week break Neither Delta first minister promises medical infrastructure will lead to bowser rivers and others These are some of the headlines you find this morning on this day newspaper Very quickly the nation needs to perhaps the following headlines. How I will boost Economy enhanced security by Tiddable how I will boost the economy enhanced security by to the way PC candidate promises So the same Buharis legacy it's a picture of the candidate there Flanked by the vice president the second to the government of Federation and the FCT minister the federal government's minister Retreat holding a sit house conference and taboo job more from the nation now weekend doses so all for second term Dumps PDP candidate as well the nation is putting in those surprises there governor's demand police a state police others Constitution review Stalled and some headlines on front page of the nation Away from the nation. We have the daily trust newspaper and the daily trust says despite one billion allocation Constitution amendment in limbo Very interesting 25 states with whole votes over state police others your threat wound Intermediators deputy senate president Governors for straight in review NGF moon why were you brought to nation assembly speakers quoted to say seven months ago? Buhari orders minister to prepare transition document Boko Haram killed 100,000 and displaced over 2 million people That's what the defense chief is saying and be away to Kogi who are no longer interested in 50,000 Hector land investors may shun state over hostility. That's what expat is saying. I next summons party of a electoral act violation attacks on Openant bandic attacks Niger hospital in queue to abduct doctors and others Well, these are some of the headlines this morning aren't at the daily trust All right, and finally the punch has the following headlines political rally attacks. I next summons parties police plan one a 13 rather billion narrow firearms purchase And we have some writers to that story there terrorism Lofage's Nigeria stock plunges amid 778 million dollar fine till we launch his campaign on veal's manifesto Friday In surgeons he killed 100,000 displaced 2 million this according to the chief of defense staff as a picture They are flood victims in an internally displaced camps persons camp somewhere I think they should be in a number of state and the story headline underneath Flood victims battle hunger risk disease in a number of these are some stories on the front page of the punch and others Probably bringing I guess legal practitioner and public affairs analyst tunic. Well, I miss a call away. Good morning And thank you very much for a time All right, I Want you to look at the situation of You know things in the country that with two headlines captured on a front page of different papers number one Is a picture story on the front page of the punch of IDPs? persons is placed by the flood is on the front page of the punch and the headline Flood victims battle hunger risk disease in a number that's one Then we look at a front page of the nation. You can also go to the front page of this day and you have pictures of political leaders as a presidential ministerial retreat Holding at the state House Conference Center in Abuja as far as you're concerned and this is amidst laughs as far as concerned Um, is government is government doing justice to Nigerians in its handling the way it's handling the flood situations Why I'm asking this is because in some states The entire state is flooded like by also state and people don't have access to food Just food. They don't have access to food I So they go out here in the handling of this matter and they show empathy with the people that have been affected. For example, in the U.S., and then back in town, and someone is in a place that is absorbed and wrapping their hands. Three of the prime ministers of the country. You see the prime minister. Generally, most of those places that are affected by floods, they have also created special places for them to be able to manage themselves, leave it and sleep. And then they provide them food. And then the security people, the army, the soldiers, the national guards and all that. They've also been part of some of these places where floods are raging and where people displayed are being kept. But that is not the situation we are finding ourselves. That's why we saw the politicians tend to ask us to make the right decisions and say that they are going to win the next election. But if I even go deeper into that, let's examine the origin of the floods that we have in some parts of the country. Some of the documents that I read indicated that when Cameroon was going to dam in a van way, there was a memorandum of understanding that Nigeria will also create a dam, or will also build a dam over river Henry in the south part of Nigeria. Such as anytime there is flooding, or when the dam in Cameroon is filled up and they want to release part of the water, the Nigerian dam will be able to hold the water that is released so that it does not go flooding the dams of Nigeria. Such as Paraba, Genway, Kogi and Warazo. Forty-two years after the memorandum of understanding was signed and Cameroon has built its own dam, Nigeria has not been replaced to build a dam that will be holding whatever water is released from the dam that is built by Cameroon. I am told that is the source, the significance of the flooding that we have in Nigeria, almost on another basis. The implication of this is that we have refused to plant. And what the politicians are also doing after work, when people are dying through flooding, when farmland has been washed away, when houses have collapsed and other, there is also enough empathy for the people who have been affected, for the people who have been displaced from their homes, and now living as refugees in their own fatherland, it just shows you the mindset of the people that we have in government, that they have the two or no respect for the lives of the people and that what empowerment to them is how they will win elections and stay in power in perpetuity. What are your thoughts on the unending constitutional review or constitution review as it were? That is on the daily trust. Now we know that since 2003, there is always one billion that has been voted for, located to the two chambers and the Ninth Assembly has since been on this particular issue. The 44 bills have been put out, but we seem not to be making progress. Is that really... Okay, so I allow you to answer this. My question is, what do you make of this on ending process, especially when we have critical issues, such as state policing among others? Constitutional review is a very, very complex matter. Well, the proposed amendment, you have to draft it. The legislators at the state level and at the federal level, we have to take it to the different consistency and do public hearings on them to see whether the people are in tandem or agree with that amendment or not. And of course, you and I also know that all the statutory states of the federation, including Nabooja, will have to sit on the proposed amendment and vote here or no. Before the thing, again we'll be taking all the amendments, again we'll be taking it to the National Assembly in Nabooja for the Senate and the House of Representatives to sit and debate it. And then if the statutory state of the federation, even if it's more than to talk, the National Assembly in Nabooja, that is the Senate and the House of Representatives, cannot pass it into law. With the time that is left in the hands of the government in power today, which is just about six months, I am not to show that there is enough time to go through all the steps that you have to go through before the amendment can become a lesson. But don't forget, the campaign for the federal elections have also started. And you and I will know the average politician will put more priority on the campaign so that he can get elected either as Chancellor, either as Senator, either as President or as President. So where is the time for this political party to hold us or for this politician to now be voted this constitutional amendment? As far as I'm concerned, the proposed constitutional amendment is dead like a doto. There is no way you can see the light of day within the short span that we have left. The one bill or whatever has been voted for that is just money down the drain. And then you ask yourself again, how many times are there amended American constitution, which is more than 400 years old? I'm not to show it's up to 10 or 15 times. And the volume of the American constitution, the one I have, is no more than 15 pages. The implication of that is the problem Nigeria has is either it's just this constitution entirely and do a new draft or we manage ourselves through customs, precedence, the decrees that the governor and the president can consign and influence. So you have said that timing is a major issue, so there's no time and we understand. So if we have not been able for a very long time, including the Ninth Assembly not being able to achieve an amendment of the constitution, 44 bills have been transmitted to the state and that has not returned. And you're saying that yes, because of the process that's involved. What's the guarantee that if we need to trash the constitution that you have said, we need a new constitution. We also require the same process. So we probably might never have time. It brings me to the next question, whether time is really the issue or is the issue of a political will? We don't maintain, we will not change the issue. It's the fact that it's the issue now. Say for example, if immediately the government won the last election in 2019 or even in 2015, it admit the constitutional amendment, its priority. Or even a whole day review, a draft of a new constitution. The problem will not be having the challenges that we have in our hands today. But the truth of the matter is that so many politicians are not interested in having a wholesale amendment of this constitution. They don't want a constitution that will work for the Nigerian people. Because as it is today, have so many problems, so many challenges. But in fact of all those challenges, it is fact-true that certain people, very well and to their own taste, such that the kind of amendment that certain people or certain sections of the country are proposing will undermine their own personal interests. For example, I am aware some states, some politicians don't want to set police. I am sure, and I know as a fact, some politicians will not want to revenue a location formula to be reviewed. Some people are comfortable with the way and manner the national resources is allocated today. So, if you don't have a concordance or a concordance or an agreement by all the different classes of politics in the country, if your name is difficult, call you to amend the Nigerian constitution. And then every year, or every time that you have a new political class in power, billions of Naira will be voted, which will go down the drain or go down their pockets, all in the name of constitutional amendment. All right. Very quickly, sir, because of time. This CDS lucky rubble has been speaking recently and he's talked about the insurgency in the nation's northern parts that has displaced persons. He actually has put a figure to it. It says two million people have been displaced and 100,000 persons killed. It's captured on the front page of the punch. What are your thoughts on this? Do you think that the chief of defense staff in the Nigerian security architecture has been able to handle the situation better in recent time with its successes against the terrorists? It's a very, very delicate matter. Putting the books on the table of the chief of defense staff might not be appropriate. You and I know that initially, they were handicapped with regard to the necessary equipment which we took by the insurgency. You and I also know that there's a political undertone to the fight against this insurgency. We have already said in the past when certain persons or when the certain presidents wanted to face the insurgency squarely, some people came out that it is a design to kill their own people. There are many people out of the conscience of whatever actions or whatever steps and whatever manners in which they handle this insurgency that they have in their hands. Don't also forget that there is international criminal court. We talked about the genus. We talked about violation of the army rules and laws or rules of engagement. And of course, you and I do know there's also a religious undertone. So this insurgency matter. The chief of defense staff, I'm sure, is a Christian. If he goes out there, unleashing all the assailants in his arms, he could be a king of problems. Pressing certain political systems simply because he's a Christian. So it is very complex. And also remember that this insurgency that we have in our hands and the IDP that is created is man-made. It was immediately certain people insisted on having a sharia in the country, rather than run Nigeria on the secular basis. That they get the impetus. So they are on youth to begin to have a sharia and an Islamic state, a geographic state of the Nigerian freedom on Iran's table and decide whether they want to run Nigeria as a geographic state or as a secular state. We will never see an end. We have to go now. We have all over the country. We have to go. Thank you so much for your time and the insight into some of the issues. We appreciate you, Tunde Kalawali. Well, Tunde Kalawali is a legal practitioner. And that's it this morning on After Press. We'll return tomorrow or things being equal. We take a break and just before that break, let's tell you what happened today in history. Please stay with us.


This is stock number 90231B, we are here at Summit Automotive in Fond du Lac, Wisconsin, you're new and used. Light duty truck and ram headquarters. Today we are checking out this super clean 2009 Dodge Ram 1500 crew cab short box. This truck has a 5.7 liter V8 Hemi motor. And it has been fully safety and inspected by our service shop, has a fresh oil and filter change. The fluids have been checked and topped off. And this truck is 100% mechanically ready to go. Infernal crystal red pearl is the color we shoot all of our videos in 1080p, so if you have HD capabilities on your computer tablet or smartphone device, turn them on right now because it is like you're right here looking at the truck with me and definitely your best way to check out the vehicle before seeing it in person. From a quality and condition standpoint, comes with the 20 inch alloy rims with the chrome covers. And it has like new Goodyear Wrangler 27560R20 tires, these tires were recently put on right before the truck was traded in, so they got about 80-90% of the tread on there. Front fender is in excellent shape, I didn't see any dents or dings on that. Front bumper is in really nice condition as well, it does have the factory fog lights. The chrome trimmed grille, headlight lenses are nice and clear. Passengers side fender is in excellent shape as well. And the passenger side rim, no scuffs or scrapes on there. As you go down this side of the truck, you'll see just how clean the body is, how reflective and mirror-like that paint is. And we take these HD videos because these are used trucks and we want to make sure that you're getting the most accurate representation possible of the vehicle. So when you get here there's no surprises, there are some dents and dings on the box side here, but it is a used truck. Overall though, I think it's in great condition, the cab's in nice shape as well. We offer a Summit Auto Fastpass in the upper right hand part of your screen where you can apply for financing, get pre-approved, and even check out payments, check out a trade if you have one, all from the comfort of your own home. So when you get here, you'll be 100% ready to go. We offer that, so click that in the upper right hand part of your screen. Our rockers all look really good, I didn't see any major corrosion there. Back rims, same condition as the rest, and the back tires are just as new as the front tires. It does have the plastic wheel well liners, which keeps your frame and underbody looking good. But other than a couple little dings on that box side, I didn't see any major corrosion or anything. The tailgate, pretty nice condition as well, get a really good idea of that Inferno Crystal Red Pearl. Does have a ding on the tailgate there. Has an access soft tonneau cover. I didn't see any rips or tears on the tonneau, and it does come with a drop in bed mat. Bed itself is in pretty nice condition. Just a little bit of light duty usage. Tailgate shuts nice and solidly. And as you go down this side of the truck, about the same condition as the driver's side. There is a dent on here, but that's just the nature of a used truck with high mileage. But I didn't see any corrosion or anything, and the rockers look pretty good. Wheel wells look pretty good, I should say. That's why we do the video, so you get the most accurate representation possible. And the back rims about the same condition as the rest. That tire is just as much tread as the rest of the tires. Going down the rest of the side of the truck, no dents or dings on the doors. It does have the heated power mirrors with the built in directional signals. You do get windshield or glass etching, so that number is etched on all the pieces of glass so that no one can steal the vehicle on you. If they do, they got to break out all the glass. Little safety feature there. Didn't see any rips or tears on the seats. Power driver's seat. We do have some Ramel weather floor mats in here. Auto headlamps, power pedals, power windows, power locks, and power mirrors. And as we hop inside the truck here, you can see that this one has 114,880 miles. You do get a compass and temperature display, as well as a mileage to empty and mileage display there as well. Instrument cluster is pretty nice and clean. It comes with the leather wrap steering wheel, cruise controls on the bottom there, information center controls on the left, AM, FM, and serious XM radio capabilities on this radio. Turn now four-wheel drive, and you do get the automatic transmission right there. Pass in your side floor mat and seat are in excellent condition. No rips or tears on that. It does come with the side current airbags, and the headliner is in excellent shape. Map lights, power side and rear window, and you do get your home link buttons for your garage door security systems and lane systems and your auto dimming mirror. We'll take a quick look at the back seats, and then we'll check out under the hood. You can see that window hatch security, right there, it'll focus on it. Anyways, it's right there. Back seats, just as clean as the front seats, no rips or tears back here. It does have the latch child safety system back here. It does have factory and that matching ram all-weathers back here, and you do get storage underneath these back seats, and it does have in-floor storage on each side. You can take those bins out for easy clean. You can actually put ice and drinks in there, so it's like you have too many coolers wherever you go. And finally, it does have the child safety locks on the back doors, and we'll take a quick look under the hood. I would personally like to thank you for checking out the video today, and hopefully from this HD video, you'll have been able to tell just how clean this truck is all the way around inside and out. Under the hood, we have the 5.7-liter V8 Hemi motor, engine bay is very clean, runs very smooth. This truck has been fully-safetyed and inspected by our service shop, has a fresh oil and filter change. All the fluids have been checked and tapped off. The truck has been gone through mechanically 100%, and is 100% ready to go. Not perfect, but really great mechanically, and pretty nice cosmetically too, considering the age and miles on it. And to see more pictures of this truck, or one of our other 450 new and used cars, trucks, SUVs, minivans, wranglers, halftones, three-quarter-tons, one-tons, you name it, we got it. Go to our website, www.SummitAuto.com. Full pictures and descriptions of every single vehicle from two locations, all at SummitAuto.com. And if you'd like to check out more HD videos, you can go to YouTube.com. Remember to like, subscribe, and share on this video and all the videos that you see there. In fact, in a second, you will see a link to a subscriber to our YouTube channel on your left. Like duty truck videos like this one on your right, if you have not been to our website on the bottom link to this vehicle on our website, click those, check us out. And we really look forward to helping you with this super clean 2009 Dodge Ram 1500 Crew Cab Short Box. Thanks again.


This video will talk about exponential modeling. Here's our first example. The number of deaths per 100,000 women in the United States is given in this table. Let d of t be the number of deaths per 100,000 women in the United States, t years since 1900. So we have 1930, and it's the number of deaths, and so on. This is going to be my L1. And L1s are going to actually be 30s. Because it's 30 years since 1900. 40, 50, 60, 70, 80, and 90. And then these values will be my L2 values just like they are. So if I come into my calculator again, remember I hit stat and then edit to get to where I am here. And I put in my 30, 40, 50, 60, 70, 80, and 90. And then I arrow to L2. And I put in 28, and 21, and 13, and 9, 6, 5, 4. Now, I have to determine what kind of regression that I want to do here. Because it asks me to use regression. But if I look at this, it's definitely decreasing. But it's not decreasing by a lot. And in fact, I was having my son help me do this. And he says, mom, I know this is exponential.  So that was just one way that you might look at that pattern. I'm going to use an exponential. But if I didn't know that, in fact, let's go in here and do this. I didn't know that I could come in and clear my equations out so they don't get in my way. And come up and turn my plot on. And remember, we can do Zoom 9 to look at our data. And when we do that, now I can see that that definitely looks like an exponential curve, a decreasing exponential curve. So I am going to use stat over to calculate. And then if I arrow down here, once you know this, you don't have to arrow down every time anymore, 0 will give me my exponential regression, press Enter. And now I know that d of t is equal to, rounded into two decimal places, 74.21. That's my a times b, which will be 0.97 if I rounded two decimal places, to the t. So here I have my function written again just to remind us. Estimate the number of stomach cancers for 100,000 women in 2,000. Well, it was beginning, if you go back and read the problem again, it was since 1900. So in 2,000, we know that t, that's a year, so we know that t is going to be 100 years later. So we just plug and chug. In fact, if I put my equation in my calculator, 74.21 times 0.97 in parentheses, caret x. And then I go and say, second window, I can tell my table that I want to start at 100, so I can see when x is 100. And in my table, table says that we have 3.5289, or approximately 3.5300,000. So actually, it's going to be 353,890 deaths in 2,000. Now remember, the data that we had was back here, was 4, but that really meant 400,000. So when I write it like this, it's 3.53, but I'd have to say 100,000 times 100,000. Then it asked me, what would be a reasonable domain and range? Well, we know it started in 1900, so it's when it began. And we're going to go up to whenever we think it might be 0. And if you look at this, it's going to take a long time to get to 0. In fact, if you remember about exponential functions, they get real close to 0, but never get there. So I mean, we could really say just about anything we wanted to in here. But what happens if it's 200 years from now? And in 200 years, we're getting closer to 0. So maybe we're going to say, OK, we'll consider 200 years. So that would be a domain of 0 to 200. Some of you might have said, no, let's just go to today. So you would have said 0 to 112. That's good, too. I'm not real picky about what this. It just has to be reasonable. Infinity, we hope, isn't reasonable. We'd like to cancer so that we won't go forever and ever and ever. For our range, we know that it started out with 2,800,000. And we hope to get down to 0. In 200, we knew that we were at about 0.16. So if we really wanted to have these things related, we'd have to say, this is where it began, and this is 200 years from now, how many there were. So the deaths would be from 28. Again, that's 100,000 to 0.16. And we know that this is in 100,000s of deaths. All right, another example. Intensity of light decreases as you go deeper in water. The intensity for separate deaths is given in our table. And we're going to use regression to find a model. So let's go back to our stat and our edit. And we're going to have to clear everything out so that we can start fresh. So clear all that out. And we put in our L1. It's going to be depth, so 0, 1, 2, 3, 4, 5. And then we put in our Ys, which are L2, and the intensity. So we have 100% to start. And I missed something somewhere. All my 3 and my 4 went together. I would have gotten an error here, because I had more things in L2 than I did in L1. So I always double check that before I go look. And then I can see right here I did 34 instead of 3 and 4. So I'm just going to arrow over and back up, make this 3, and then Enter, 4, and then Enter, and then 5. And then I should be all lined up and ready to go. And if you look at this, it does look like it started out with a big number and ended with a very little number real quickly. So that should be exponential. But again, we could look at our data. And it definitely looks exponential. So stat, over to calculate, 0, remember, was exponential regression. There it is. So press Enter. And we have I of D is going to be equal to 98.09 times 0.25 to the D. Remember, these variables need a match. And we want to estimate the intensity at 6 meters. So this is a D. So we want to put in 98.09 times 0.25 to the 6. And if I put my equation in here and then second window again will let me tell it what x I want. I want it to be 6. And when we plug that in, we find out that it's 0.02. And remember, this is a percent light at 6 meters, at the 6 meter depth. Reasonable domain and range. I would say that our table looks pretty close to being a pretty good domain and range. We know it's going to be a little bit more than 5. If we look at our table here, if we really wanted to say 0, 0.0015 rounds pretty close to 0. If we go to 9, it's 0.7 times 10 to the negative force. And now we know it's getting closer and closer and closer. But again, we're never going to get to 0. So I'm going to say maybe 0 to 10 would be close. Would be reasonable. 0 to 10 meters for the domain and for my range. That means we went from 100. And we got pretty close to 0. Since I have a parentheses on here, it means I get close to 0, but I never get there. The following displays a number of Starbucks stores worldwide since 1991. And it's going to be important that since 1991. That means that in 1991, zero years have gone by. In 1993, two years have gone by. 95 would be four years. And 97, 6, 98, or 99 would be eight. 2001 would be 10. 2003 would be 12. So those are my L1s. And the number of stores here would be my L2. So I've already put that in my calculator. And now I'm ready to just go find the regression. So stat, over to calculate, and 0. Exponence regression. So I'm going to see that it's exponential because I've got a small number to a very large number very quickly. And when I find that exponential regression, I have 142.21 times 1.41 to the t. So what is the percentage growth rate of Starbucks stores? We haven't talked about percentage growth rate. But the growth rate is going to be that base of 1.41. And we're going to subtract 1. And that would give me that growth rate because this is bigger than 1. So if I take 1.41 and I subtract 1 from it, I'm going to end up with 0.41. Or that's the same thing as 41%. So that's my growth rate. If this had been a decay, I would have had 1 minus the b. This b minus 1 would have been switched around. And it would be 1 minus b so that I can get a number. Because I start with a number that's smaller than 1. If I subtract that number from 1, I should be able to find my percentage. That would be a decay. So now I want to estimate the number of stores in 2010. Well, that tells me that t, we started in 1991. So t is going to be 19. So now I just have to plug and chug. And I'm going to go to my calculator to tell it, let my table do the plug and chug for me. So I'm going to start at 19. I've already put my equation in there. So I have 97,296 stores.


Alright guys, we're gonna start we're gonna begin using the decon kits of this time So go ahead and grab your M291 out of your pockets Deconning your hands and then your face as instructed earlier and make sure to whenever you dispose of the The little baggie that the pad comes inside of put it at your feet at least so it doesn't fly away Making sure that you're wiping away from your body You can go ahead and start with your face. Yeah, I just After you're done with your hand make sure to do the outside of your mask first to where I took your skin And then whenever you're done with that make sure to hold the front of your mask loosen the strap from the sides And then you can then break the seal make sure to close your eyes and hold your breath again And you can begin on the inside of your mask just sticking your hand in through Between your mask and your face you grab an alarm For example Make sure to always also, let's say you're deconing anything that's in your hand your ACH Same thing with the M291 you decon away from your body You don't want to put any of the other contamination back on your body. It defeats the purpose so Yeah


Okay. We're going to resume with our last concept presentation, and this is like the first. There will initially be a report. This is for the genomic technology development. There were two workshops that were held in early April, and first, Michael Smith is going to present the results of those workshops, and then go into the concept, which is based on the recommendations of those workshops. Mike? All right. Well, thank you for listening to this today and considering the concept. What you're going to hear about today is the workshops that we held, the overall goals of the concept, a timeline, two initiatives. I'm actually going to slip the timeline between the two initiatives to help break it up, and then an overall budget. And actually at the very end, I will talk a little bit about this budget versus the $1,000 genome budget because I know that's one of the questions that's come up. So we did hold two planning meetings. They were actually webinars, and we got a good turnout. We got pretty much very many of the people that we invited agreed to participate because we were able to meet their schedules, and I think they particularly enjoyed not having to come to Washington for a planning meeting. You can see that on April 10th, we had one of our council members, Joe Ecker, there, and on April 16th, we had Jay Shenduri. I'd also like to point out Hanli Ji, who helped us write the meeting prospectus. And just in general point out that we had a nice group from across both academia and industry. We felt like that was really an important thing to shoot for, given that technology development has to sort of perhaps start in academia, but also has to become something you can buy as a kit at some point to really have the kind of impact that it can't have. So we did hold these two webinars, and we charged the participants with helping us identify areas of really good opportunities, priority, and biology and disease. And you couldn't hit one of those three or two of those three. We wanted things that hit all three, right? So where are the best opportunities, priorities, and biology or disease? Where are those sweet spots today? And where are they going to be in the next five or ten years, more importantly? So I'm going to give you pretty brief workshop recommendations, because they're largely rolled right into the concept, into the initiatives. And we worked on this earlier, there was just no reason to keep repeating. So what we heard very strongly from the group was that there was a really wide area of technology development that's ripe in genomics today. And it's stretches across new DNA and direct RNA sequencing methods, but that there were also many other areas. And we needed to try to think about how we could help encourage those areas for the benefit of the field. Again, the details are in the initiatives. We heard also from the attendees that technology opportunities, we really wanted to give investigators an opportunity to tell us what their best ideas are, and you'll see I think the way that we're going to do that. And that the applications benefit both from dedicated review and from a solicitation in terms of getting them here and having them reviewed well. So getting to the concept, the goals are to facilitate development of new genomic technologies, not this year, but in five to seven years or longer time frame, specifically solicit new technologies for novel nucleic acid sequencing, both DNA and direct RNA. And just provide a new avenue of support for genomic technology development, which could really span a wide gamut of applications. And we'll get into what those are a little bit later. But clearly, there's a lot of opportunity in genomics these days. You think about how many pretty fundamental things have gone on in the 10 or 12 years since the $1,000 genome RFA came to this council before all of you were here, although maybe one of two were at that time. So the initiatives, a novel nucleic acid sequencing technology development initiative, and then genomic technology development awards. That's where we're going, and I'll describe the first one. So the purpose here is to develop revolutionary nucleic acid sequencing technologies. There are likely additional ways to sequence nucleic acids that we don't use today, that if they worked really well, would revolutionize the field one more time. And so if we can find those, that's really important. That's what we heard from the workshop, and that's what we're aiming to do here. The other thing we heard loud and clear, as part of that was, again, there was a revolutionary technologies that could really impact highly. We also heard that we've been sequencing RNA via CDNA for a long time. And we really ought to come up with some methods for direct RNA sequencing. So that's part of this concept. We'd like to have long read lengths, high accuracy, and low costs. Or if you know the old joke, you can only have two out of the three. But we'd like to have all three. In terms of support, we're looking at $2 million additional total cost dollars for each of the next four fiscal years, 16, 17, 18, and 19. That would put us at two to four awards per year. The RO1s on the order of, say, four years. R21s for three years would give people a little more time and a little more money than you normally get out of our RO1s and our R21s to do this work. Because we realize that you've got to have different sets of expertise on any one project frequently. And that just takes more time and money to get it done. And then we would also work in the SBIR and STTR domain. And those monies are not indicated on this slide. But we would certainly be trying to find applications in those areas. Because I can also have an impact on the field. Along the bottom of the slide, you can see the, I'm not gonna. Along the bottom of the slide, you can see the dollar amounts in the fiscal years, you can see it ramps up as we issue $2 million a year and then it ramps back down as the commitments end. And then it's easier to think about this a little bit by what kinds of things might come in under this particular concept or initiative. So new chemistries or physics or instrumentation for really new ways of sequencing DNA. Some important areas include just fully sequencing all the nucleic acids in a sample. So not this, the luminous sequencer maybe you sequence 50% when you're doing really, really well. But fully be able to characterize that sample. And then very long reads, because we realize that those could be very important for de novo assembly. Direct RNA sequencing of full length transcripts without a CDNA intermediate. I already spoke about that. And then several orders of magnitude improvements to existing sequencing technologies. That's another way to get there, that would be fairly revolutionary. We all want to do all of that without paying too much more money. So I said I would break the two with a timeline. So you've seen the timeline like this that's very similar from ENCODE. Concept clearances today, FOAs released in the summer. Review in the winter, coming back to council this time next year. And then funding in that summer. But we would then have three more rounds, right? Because we're going to be issuing new money. We're going to have to be soliciting in FY16, FY17, 18, and 19. And that means anybody who comes in, say in FY16, and perhaps just misses the funding line or gets something really significant pointed out in review will have an opportunity to come back in. Maybe with some new data, whatever they do to make a better application. So this will be an ongoing process to try to make sure we get the best genomic technology development we can for those four years of funding. The second thing we would like to do is to have genomic technology development awards, this, and I should have said on this sequencing it was an RFA. I know it was on one of the slides, but that would go out as an RFA. This is going to go out as a PAR that just says we have an interest here. We'd like to see applications in this area. And the idea is to catalyze investigator initiated genomic technology development in that five to seven year time frame in terms of impact. And we think there's a wide area. I thought I would address, when I got to this slide, what that wide area was. That's what I'd like to do now. So really high throughput, high information content, functional assays. We should read genomically as one area. We think we might see some applications. Single cell methods for everything, anything we're interested in pretty much. You can do it on a single cell. We heard loud and clear and that that was a very high priority area. Foundational technologies, something as simple as extracting all the RNA, all the DNA, and all the protein out of a sample. Even better, a really small sample for analysis. Transcriptome analysis, other kinds of functional analyses. Down to dollars, three millions total cost per year. That's RPG funding. Again, for four years, FY16 to FY19. We're thinking three to six year awards per year. Same sort of timing and dollar amounts on the RO1s and the R21s, we're thinking of. And again, SBIR and STTR funds are something we try to use in this area. We already issue awards in the SBIR and STTR domain in technology development. So this is just an effort to sort of get more applications of high quality in those areas. Again, you can see that ramp up and ramp down of funds along the bottom of the slide. Here's some examples, some of which I've already mentioned. I won't read them again. There certainly would be room in here, for example, for some CRISPR-Cas9 type applications that were really genome wide and big impact. Scaling DNA sequencing to many, many samples. I think one of the things we heard from the workshop, and we just know, is that if you could sequence a genome for significantly less than $1,000, by several orders of magnitude, then that opens up a whole new set of experiments. In situ methods for everything, DNA, epigenome, RNA, protein, transcriptional, dynamics, and then generating sequence tags at very, very low costs. Some of the programs we're running right now spend a lot of money just getting the sequence tags. And so we could have a pretty big impact if we could get the costs of that down, and probably enable many things that aren't even being done today. So the summary of the money that we're talking about for these activities, 2 million ramping up to 8 million in FY19 for the nucleic acid sequencing technologies. 3 million ramping up to 12 for technology development awards. Five ramping to 15, and then you can see it ramp back down. In the next slide, just shows a little bit of where we were with a $1,000 genome. So in FY6, 7, 8, all the way out to 17, you can see the commitments. The $1,000 genome was sort of in the 20 to $15 million range for a while, and then it's been ramping down and ramps down in 15, 16, and 17 because we made no awards in 15, 16, and 17. And you can see it's ramping down by about $4.5 million a year for the next two years. So that's at least gonna help pay for the first two years of this concept. And I should say a few thank yous. Bianca, Katia, Chris were really helpful with the webinar. Bianca with many things she was key to just helping pull the webinar and other parts of this together. Elise, Mike, Adam, and Betty, this is my first time I brought a concept up here. Helpful for knowledge and feedback and everything else and many others. Jeff, I mean the $1,000 genome is his baby and I've learned a lot from him about genomic technology development and how the NIH works and he had a lot of input into this. His name could have been on the first slide. Hanley, Joe, and Jay have helped in developing this concept. And we had 21 other people in the workshop and we also had a follow-up server I haven't talked about that was useful in all of this together. So with that, I'm ready for questions. Go ahead, Joe. One thing that was in the report that you didn't mention was that because essentially the funds for the $1,000 genome were being split into these two areas. And there was a, let me first say your summary was very accurate regarding the webinars. And in thinking about what the sequencing part would do, there was a consideration that the new technologies would not over a lot much with industry, given less money, but yet still a great desire to attack these areas that there would be. So that would be worked out how with by. I think the best we can do is be aware of what's currently in industry and we try to do that our reviewers are usually pretty darn aware of that also. So I think that's in reality at $2 million a year compared to what some of these companies are spending, but they're probably working on things that would be more immediate than we would think this DNA sequencing or nucleic acid sequencing initiative would go to. I'm going to move us back to that slide because I can tell that's what we're going to be talking. I should have done that earlier. Okay, Tony? With the increased mandated funding for the small business pot of money, is there any way of cutting this back and forcing some of that mandated money to be small businesses in collaboration with academic groups to develop new technology, rather than it all being new money? I believe the increase is around $500,000 a year that we've been saying. And so, it's been going up by 0.1% every year. I thought we saw an increase of several million. Those numbers are all over the place in part. The numbers you saw earlier are showing new spending in a fiscal year. So anytime we issue, say, a phase two that has two years of support, then we've committed money next year. And so that's a large reason why those numbers will bounce it around like that. I didn't say anything at the time, but. Sorry, that must be thinking of the wrong slide. I saw a large increase in funding for small businesses in one year mandated. I don't understand why some of that can't be put to this. Yes? I thought I'd probably go from like four to eight or it doubled. But our small business dollars, I happened to coordinate the small business program at about $11 million a year. And it's been going up by about half a million dollars a year for the last couple of years and will for the next year or two. 0.1% of the budget. Why can't some of that be used to get small businesses to collaborate with academic youths rather than- Well, in fact, we just came back from the genomic technology development grantees meeting last week and we had many small businesses there that were doing DNA sequencing and other things like that. And they were funded out of the SBIR pool last time. So when $1,000 genome we were funding SBIRs there, that's what we're talking about. I thought what I was hearing Tony suggest was a mandatory linking as opposed to wouldn't it be nice if they came and they spent some of our SBIR money. I'm hearing and I don't even know all the legalities and the policy. But what I thought I'm hearing Tony put me wrong is some sort of a requirement or I mean a designation that this is the way SBIR money is going to be spent. So we use more of that money for this and less of our colorless money. Thank you, Eric. Yeah, okay. But is that legal and is that possible? I just don't even know the feasibility of it. It doesn't, the legality is hard to know but it could be encouraged in some way without saying, well, you wouldn't be selected against if you didn't. But having an academic partner is something that's encouraged that you could include that in the description. I think what I'm hearing is sort of a suggestion to invest less of our undesignated money and force better use of SBIR money in a way that might be a win-win. Especially if you feel the scores on the SBIR grants are not up to the same levels of- Can I address that directly, please? Which is this year the scores are pretty much right at the same level as our R01s and our R21s. So they are very competitive this year. They were a little less competitive in the year or two before that. But I think they're going to continue to be competitive going forward and I could talk about the SBIRs for a while, but that's. So we have a practical question and I confess I don't know the answer to it because I don't do SBIR reviews, but I'm looking over at Betty. Can an SBIR applicant have an academic collaborator and if so, what are the budget splits that are allowed? Okay, so what are the budget splits? Is it 50, 50, 51, 49 or 99? I can answer that question also. Okay, so on an SBIR, it's up to 30% can go to academic partner. And the vast majority of our money is SBIR. So in the STTR domain, it's between 30 and 60%. It has to go to the academic partner. But I would take STTRs largely off the table because the budget amount is like a million dollars, it's so small. Sorry. Can you change the distribution between SBIR and STTR? That's congressionally mandated, the percentages are. Because I was going to say that the STTR program is a way to do this because up to 60% can go into the academic domain, which would be great because then it could do, I don't know, an RFA around that. But if it's a million bucks, it doesn't really help. And there are a lot of other restrictions we haven't gone into. Go ahead, Jay. Mike, can you comment on the difference between the practical consequences of setting up the second part as a PAR as opposed to an RFA? I think others probably can comment on that better than I, but I will try. In an RFA, it's more dedicated dollars, which is what we were talking about earlier on.  Betty's raising her hand. She's going to have a better answer than me. So the RFA is dedicated money and it comes through concept clearances. The PAR is really a program announcement with the review being done at the institute level rather than CSR. So it's just a program announcement. No set aside, you're just saying, this is what we're interested in. And by the way, it won't be reviewed by CSR, but it'll be reviewed by G. Which is what our segs in. So it looks like a set aside up there, but it's not really in the practical sense, meaning you have more flexibility. Planning target number. I see. Jeff, go ahead. With respect to the SBIR, there's one real challenge of trying to do this all by SBIR, which is you have to have a business plan for an SBIR grant. And a lot of these projects are way too early to have a business plan. You don't even know if the technology is going to work. If we're in the space that we would like to be in to explore new technologies. So we want to use SBIR to the extent that we can and bring additional dollars. But I think it would be a mistake to try to do this mostly with SBIR, just because we're trying to stretch. The other point with the PAR is it's sort of an aspirational goal, but we do need to talk about whether we want to try to in some sense set aside funds to be able to do that, versus have that compete with all the other applications that we get. That's a discussion for later on probably. Yeah, just about. So from a non-technology development person at the workshop, you've got what seems to be a pretty lofty goal here of getting these three pillars. Did the panelists actually feel that this amount of money would move the needle? We asked them that and what we heard was they thought we would get high quality applications, which is one of our concerns. Was it so little that we wouldn't get a quality applications? And I think we heard it would move the needle some, but like a lot of these things, there's more need than there is money. So we're trying to fit in. The money's better than none. So you'd expect that response. I was just curious if you really expect to make much of a dent here. We've made, we think, significant dents in the past with this amount of money. Yeah, so I mean, at least as I recall it, for the $1,000 genome RFA, the response was pretty vigorous over the years in terms of applications for basically the same amount of money. I mean, you're funding individual investigators for projects that aren't super sequencing driven. And so five million bucks actually goes a pretty long ways, especially when it's, you know, it's every year. It's another five million. So I actually think there's a, I mean, there's a community you could, you could pretty effectively fund here to try out a lot of ideas with this amount. I think one thing that hasn't been mentioned along those lines, and Jay asked the question on the phone earlier was, could this be a place where someone who was interested in a SEGs, but maybe didn't have enough to turn in a SEGs application, could sort of get their feet wet? And I think there are a lot of good ideas that aren't big enough for a SEGs. And this is a good, would be a good place for it. Yeah, we were calling mini SEGs. And, you know, for the, at least for the second objective, that the money is big enough and you could potentially have several collaborators on something like this, but not a full blown SEGs. So it's kind of in that intermediation here. Maybe this is all in the same lines as Long was asking, and maybe this is incredibly naive, but sort of at the end of the day, you know, one outcome might be the development of some the $100 genome, some blockbuster technology. And my concern is that NHGRI, by making this sort of little investment at the beginning, won't get any credit for it at the end. I suppose that's always the danger or the sort of the frustration of being the sort of initial funder. But where, you know, it's a philosophical question late in the afternoon. What's the role of VC? What's the role of industry? What's the role of NHGRI in the development of these, the new technologies? I mean, I understand the single cell sequencing, for example. That probably needs to start here. That's not going to start somewhere else. But fundamentally, you know, we run the risk of creating a new industry that we then end up paying for, you know, five years from now, because we don't have a stake in it. At the beginning, there's no way that NHGRI is going to get a stake in a new company, I guess. But how do you approach that kind of, how did, I mean, did Illumina come out of thin air? Did the high-seq come out of thin air? Did the high-seq come out of investments early on in a thousand genomes? And Illumina came out of a chemistry lab at top. No, that Illumina actually did, but I think Jeff's about to tell you, if you look at the instruments that Illumina now sells, there's what, about four, five, six patents that came out of NHGRI grants that cobble together to actually make the current suite. For Illumina, the my-seq platform depended a lot on technology that we supported for several years. But what we've heard over and over again at these grantee meetings is that even relatively small NHGRI investments of $250,000, $500,000, $750,000 have been leveraged many, many fold. The fact that people could get an NHGRI grant then allowed them to get additional funds to do additional development. But without the NHGRI funds, they couldn't try out those initial ideas and they couldn't demonstrate to others that they had an idea worth further investment. So, maybe I'll just leave it there. Industry generally won't start at the very beginning of these projects. I mean, it's anecdotal, but I would say when I've spoken to the Illuminas and the similar companies, I talked to their CEOs that, I mean, they say that the kinds of things that we are supporting, the kinds of things that we're proposing to support, they have almost no interest in doing. It's way too upstream. And so they absolutely think that the field has been stimulated by some high-risk things that we have done traditionally and would love to see us continue. And obviously, it's their best interest to see that happen. But within the ecosystem, I mean, I think they're being pretty blunt. This is not what they're going to be doing. So the other point to make is we jumped immediately to Illumina. And so for one Illumina platform, NHGRI support made a big difference. For their basic chemistry and so forth, they didn't have NHGRI support. For the sequencing technology, for the Illumina bead technology, we were absolutely critical, but maybe that's another conversation. On the other hand, there are a couple of other technologies out there. The single molecule technologies received a tremendous amount of support from NHGRI over a long period of time. And I have no question in my mind that they wouldn't have gone anywhere near as far as they've gone. Now, I understand they're still too expensive for the routine sequencing that we'd like to do, but we're seeing them being adopted more and more and having the potential to once again change the field. Whether they will reach the costs and so forth that people would like, we don't know. But if anybody who was at AGBT and is reading the literature has seen these new technologies emerging in a very important way. I just find it incredibly frustrating that we are sitting here trying to find $10 million out of our budget. When early seed money from this institute and others have made such a huge difference to companies that are large and getting larger. And I wish there was a way to sort of transmit that to the people who provide the money so we wouldn't have to scramble around looking for those $10 million to state the obvious. Nonetheless, this is our role. I would just, Dan, I'd say the problem, let's wish that the problem you pose comes to pass. Right? That's exactly what... The history says that it will. This is what NIH is supposed to do. It's not, the problem that you pose is not unique to sequencing technology, right? It's all of NIH is doing what pharma will not do, for instance, right? If only we could get big pharma to actually declare that to be the case, right? Show Lon some love here now. Other questions for Mike? Okay. So Council understands we're asking for approval of the initial concept. The second one is a PAR and we're not going to take a vote on that. So this is for the initial concept for DNA sequencing and direct RNA sequencing. Can I get a motion to accept? And the second, all in favor? Any opposed? Any abstentions? Thank you. Thank you, Mike.


2014 Nigeria had Nigeria along with another with a lot of African countries faced an Ebola outbreak And one of the first things we heard about Ebola was that it could be cured by bathing insult And I remember that that morning around four o'clock in the morning One of my aunties in the village called my sister who's a medical doctor and told us she got on WhatsApp a message That she needed to bathe insult and my sister was saying I'm a medical doctor You cannot cure Ebola with salt, but my aunt said I'm your aunt. I love you I don't want you and my you know my grandkids to die You need to bathe insult because that's what was spread on WhatsApp in the same way a lot of misinformation is spread via these channels on WhatsApp in Nigeria is particularly It's particularly Prevalent because it's cheaper to use And you know and it's almost transcends illiteracy because people will send videos You know people actually create videos and send and so people don't need to be literate These are some of the metrics that sit had gathered in In its research, you know studying hate speech and into dissemination in Nigeria From broadcast to media talking about you know How You have broadcast media in Nigeria so like radio television But then how it spreads to you know other forms of media whether it's online whether it's print And the the platforms that people have to propagate this on wholesome messaging Talking about a couple a number of political programming You know with fan pages created not just by the radio stations, but people who are listeners For instance Kawane Gauta on freedom radio in Kanu these fan pages generate large volumes of speech I think it's also important to say here that a number of a Number of fans of these radio stations or fans of political programming Listen to this listen to these programs because they have they are following a leader So for instance the current president of Nigeria president Muhammad Uphari has a large following in the north and so people who Sorry, I made a mistake has a large almost cult following in the north for some people. He's seen as a god And so people when when young people or people who really believe in him listen to these stations They're not listening to them to Take on any alternative information, but they're listening to protect The person they consider to be a god or the person, you know, who they follow really closely So it's really important to keep that at the back of your mind Who are the hate speech makers? They're predominantly males No surprises there educated Since they communicate mainly in English and presumably young people because age falsification is common in social media Over 60% are identifiable commentators. They're partisan various political parties Politicians come only second as a category that for audience but result as the results show audience Audiences tend to be more receptive to messages by the politicians again. This is because of the patronage system That largely functions in Nigeria So here are some examples of you know of incidents that have happened And I think the one I'm going to you know, just briefly talk about was It all is going to be president Jonathan's Speech when he conceded defeats to the now president and Muhammad Abu Hari There was a lot of I think that the 24 hours between when the results were announced and between mr. President You know between when we knew for sure that mr. President was going to concede and to when he actually did We must have been one of the most tense periods in Nigeria This is because anyone who remembers the 2011 elections will remember that when the current president Then aspirants when he ran and he lost violence broke out in a lot of places in Nigeria And so the fear for a number of us, especially people monitoring elections and roving was if he loses again violence is going to break out and he He and a number of his supporters had made a few inciting comments And so the air was really tense and you could see you know as you look at this you can see like really sharp spikes in You know in the amount of hate speech that was you know transmitted during that period So how does citad know that their campaign is succeeding? As you can see one of the things that citad does is they try to counter the these communications And I think that even citizens by themselves have created Mechanisms where they counter this where they counter hate speech, but not just hate speech where they counter false information With truth. I know that during the 2015 campaigns a group set up a platform simply to fact check what either you know What either presidential aspirant was saying From offline to online a large number of the items of hate speech our reaction to criticism of specific persons Like I mentioned that earlier while the criticism itself is not necessarily dangerous speech The reaction tends to qualify as dangerous speech quick example Somebody says something about the politician you like That information might be true or might be false. It's not inciting but the response to that is almost always inciting We've also I think and I can speak as someone who works within the you know civic CSO slash media space a lot of the times The responses you get to criticism of a particular candidate of a party Tend to be personal they move away from the issue or as a matter of fact They move totally away from the issue and they focus on the person if you're female the response tends to revolve around a few things one You know Wardham or prostitution or go and marry or you know some threat of physical harm A number of male friends of mine had their offices their workplaces Contacted to say this person is speaking against you know this politician or that person you should fire this person So beyond hate speech sometimes it actually goes into actions that could really threaten the lives or careers You know of the people who are offering this criticism And so tackling or combating online dangerous speech has to take on board more campaign on getting people to not be provoked I'm smiling because I'm Nigerian and you know provocation How are results shared and how are results shared and used so citad Organizes meetings at the end of every month a press conference in which in which they shared the analysis of results They also share a brief with you know the relevant security agencies including the National Human Rights Commission Appropriate responses to certain hate speech items have been counted using the same channels. I've mentioned that What have they learned a better understanding of the nature of hate speech the clear understanding of its channels of propagation? And they've been able to identify key moments that generated hate speech from which they've been able to identify key triggers and drivers What to do with the results? Allow us to develop more effective strategies for countering hate speech in the country I think I should stop there and mention the work of another organization called the Northeast Regional Initiative It's OTA. It's OTI funded and what they do is counter violent extremism in the Northeast by using Other young people who live in the Northeast so they have a fellows program and these fellows Hold a lot of tweets chats hold town hall meetings hold community engagement meetings to speak to their pairs because it's more effective than having you know donors or Politicians gather young people in a room and tell them don't fight with each other. Don't get it not treated Etc. It's a lot more effective when your pair or your friend is speaking to you and telling you about these things What else is stad using with using this result force used to raise awareness and to drive advocacy for both government and to develop Appropriate responses to drivers of hate speech and for citizens to not only be engaged in hate speech But also to not be provoked by it. Okay This is the end of the slide again, just to apologize on behalf of YZ Yao who was supposed to be here but couldn't be here because of this because of visa issues I think this also raises the question about you know reciprocity between countries and how The Schengen area can facilitate easier and more effective movement between Africa and Europe. Thank you


Did Jesus ever call himself God? Well, in John 10, 31, the Jews picked up stones and Jesus asked them, for which of these good works are you wanting to stone me? But then the Jews answered and said, it's not because of any good works, but because of blasphemy, because you being a man make yourself to be God. And so even if we don't think that Jesus is God or some may say that Jesus never even said that he was God, well, the Jews thought pretty clearly that he was saying that he was God. That's why they picked up stones and that's why they gave as a reason why they were going to stone him because he was calling himself God. And so we don't have to sit and debate as to what Jesus called himself. We know it's clear that he called himself God. We know that he is God and even the Jews thought so as well.


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Server Maintenance and Backups How do I maintain a Galaxy Server? What happens if I lose everything? Learn about different maintenance steps, learn what to back up and how to recover. Server Maintenance One of the important admin tasks is to keep an eye on the storage consumption. Every instance should have a data-wrenching policy defined and shared with users. The codebase contains scripts that can assist with cleaning up and reclaiming space. The GX Admin tool can assist with invoking these scripts. Cleanup scripts provide various options for filtering on which datasets to take action. Use the dry run option to verify what datasets you are about to affect. Some available actions are safer than others. For example delete userless histories. When something is marked deleted, it still exists with a deleted flag. Once purged the file is gone. You worry about aggressive storage reclamation. It can aggravate users. Well-defined and updated data retention policy brings benefits. One of the included scripts can send templated email to the affected users.  Galaxy generates intermediate data as part of the job execution. These should be automatically cleaned up unless you change the cleanup underscore job flag in Galaxy's configuration. Backups Many parts of Galaxy are convenient to backup since they are straight folder hierarchies. Use your system's recommended way to backup Galaxy's database. If you have local modifications to Galaxy's code backup those as well. In case of an incident do not rush even when pressure is piling. Careful planning of the restoration procedure will save you from hasty recovery attempts with errors. Consider running a recovery drill pretending that for example your Galaxy machine was wiped. Use configuration management, for example Ansible. Store configuration management in Git. Back up the parts of Galaxy that can't be recreated. Thank you for watching.


We are all pedestrians at some point in the day, whether walking to work, a friend's house, or to the bus stop.  Walking is the nation's most popular form of recreation, and all you need are good shoes. It's a simple and important thing to do for your health. Moderate activity a few times a day, like walking, can help fend off heart disease and other illnesses caused by inactivity. The Surgeon General recommends at least 30 minutes of moderate activity daily, and that can be done 10 minutes at a time. Walking is a way people of all ages can get around. It's the simplest mode of transportation. 40% of trips made nationwide are less than 2 miles, which is a reasonable walking distance. Walking can be quicker than you think. The average person can walk a quarter mile, equivalent to four city blocks, in five minutes.  It's everyone's responsibility to keep pedestrians safe. As our community grows and more people share the street, we need to show extra care in observing traffic laws. Anytime you are behind the wheel, be aware of pedestrians. When walking, be aware of cars anytime you step off the curb. Here's a quick overview of traffic laws that affect pedestrians. You can cross the street at the intersection of any two streets, whether a crosswalk is marked or not. Vehicles are legally required to yield to you at intersections, but be cautious. At traffic signals, obey the law and cross with the walk signal. At any intersection, with or without a signal, vehicles must stop if a pedestrian is in their half of the roadway. Likewise, vehicles must stop if a pedestrian is within one lane of their half of the roadway. Once the pedestrian is beyond one lane of their half of the roadway, the vehicles may go. The law also states, at any one-way street or two-lane road, drivers must stop for pedestrians for the entire length of the crossing. If you cross mid-block between two intersections that do not have signals, it's legal, although pedestrians do not have the right of way. Pedestrians must yield to motor vehicles in that situation. If you cross mid-block between two intersections that do have signals, it is illegal. Pedestrians are required to cross at the signalized intersection in that situation. When you are waiting to cross at an unsignalized intersection, wait for an adequate gap in traffic. Show your intention to cross and make eye contact with approaching motorists. Allow drivers ample time to stop. As motorists and pedestrians, even when we all obey the law, conflicts can occur. The most common conflict is the right turn on red. As a motorist, never make a right turn on red without first coming to a complete stop. Look for and yield to pedestrians who are crossing with the signal. As a pedestrian, be aware of this conflict and make eye contact with drivers before you cross in front of them. When making left turns, drivers are often focused on oncoming traffic, especially while making left turns across multiple lanes. As a rule, always scan for pedestrians at intersections before making a turn. Use caution when passing another vehicle that is stopped at an intersection. They may be stopped for a pedestrian you cannot see. As a pedestrian, be aware of this situation. When crossing or entering a street, be sure to look for pedestrians on the sidewalk or shoulder to your right and left, especially at one-way streets. You may be focused on the traffic coming from one direction, but remember to look for pedestrians walking towards you from the other direction. Always obey the speed limit. Speed limits are posted for a reason. For instance, a pedestrian that is struck by a vehicle traveling 40 miles per hour or faster has only a 15% chance of survival. It's never worth it to speed. When you are driving, remember the weight and force of your vehicle relative to a pedestrian. A pedestrian is no match for a 4,000-pound car. Here's a quick overview of traffic signals for pedestrians. When the signal shows a steady walk or the person walking symbol, it's okay to cross, but watch for turning vehicles. The flashing red don't walk or hand symbol tells the pedestrian they should not step off the sidewalk and begin crossing. If you are already in the crosswalk when the signal starts to flash, finish crossing. Once the signal starts to flash, a pedestrian that has already begun to cross will have enough time to complete the crossing. If the signal shows the steady don't walk or hand symbol, don't start crossing. Wait for the next walk signal. Sometimes a pedestrian will arrive at a signal and the light is green for cars, but the don't walk signal is showing. This is because there is not enough time left in the signal cycle to allow you to cross. In this case, the pedestrian must wait for the next cycle for the walk signal. Roundabouts have been installed in some locations instead of traffic signals. One of the benefits of a roundabout is it moves traffic more slowly. At a roundabout, pedestrians typically have a crossing island midway through the crossing. This allows you to cross half the street at a time. It is okay to wait at a crossing island until there is a gap in traffic and you feel safe completing the crossing. When you are entering or exiting a roundabout, always stop for pedestrians waiting to cross, either at the curb or at the crossing island. Because there is no red light, motorists must be alert to pedestrians and stop when one is present. Some crosswalks are equipped with in-pavement lighting that serves as a warning system for motorists. The lights tell motorists a pedestrian is present. As a pedestrian, keep in mind the lights are not protection. You must still use your own judgment and cross when you feel it is safe. Here are some key points about pedestrian safety we can share with children. Look left, right and left again before stepping into the street. When there is no sidewalk present, walking on the edge of the road or in a bike lane is appropriate as long as you are facing traffic. When walking during the day, wear light or bright clothing. At night, wear reflective material and carry a light. When walking or driving, be predictable. Be respectful. Make eye contact. Don't be in a hurry. Know the law and obey it. As a motorist, avoid distractions such as talking on a cell phone so that you are always prepared to stop for pedestrians. Always scan the street particularly at intersections for pedestrians. Always stop for pedestrians who are in the crosswalk. It's the law. Next time you are making a short trip, consider walking. Walk to the store to visit a friend or run an errand. If you live close to work, try walking. Walking is a chance to be outside, relax and see something new.


We will not forget the thousands of first responders, American servicemembers, and true heroes who responded on that day, and we will remember the near 3,000 lives lost on September 11th. We honor the victims, not only from our DOD family, but also those first responders around the country who answered the nation's call and made the ultimate sacrifice. It is these of our responsibilities to never forget the attacks on September 11th. Please take some time today to remember and honor those that we lost. We will remember. Rescue and attack.


Hello and welcome to CMC Markets on Tuesday the 24th of March and nearly one week on from the fallout of last week's Fed Minutes. Now those of you who watched the video last week will know that I warned that the Fed could well be a lot more dovish than the market had anticipated and despite the fact that they did drop patients they were indeed a lot more dovish than the markets had expected and we highlighted the 107 area as being the key breakout point for Eurodollar on any move higher. We've got that move higher. We've also seen new record highs on the DAX. We've seen new record highs on the FTSE 100 and we're going to look at all of those three markets in the context of where the next key levels now are in the wake of obviously last week's events and hopefully in the context of the events that we're probably going to be looking at throughout the remainder of this week and to the end of this month and the end of the quarter. So last week we looked at the FTSE 100 and on the subject of levels I highlighted the 68-60 level as really a key resistance level and if we broke above that then the likelihood is we could well retest the previous all-time highs at 69.74. In the event we've broken above those previous all-time highs at 69.74 and managed to maintain so far a foothold above the 7000 level and I think a large part of the reason why the FTSE 100 has done particularly well in the past week has been the weakening of the dollar but also the weakening of the pound. Given the higher weighting of FTSE 100 stocks that essentially report their earnings in both sterling and dollars that's going to be a net positive for the FTSE 100. So certainly in the context of where we are now I think the previous resistance level at 69.75, 69.80 if we get a dip back down there we could find a significant area of support around about 69.80. So that's the key level to watch out for for any pullback for further gains going forward. So let's move on to the German DAX and this is one index this year so far that has continued to break records beginning of 2015 we were trading around about nine and a half thousand we've made new record highs earlier this month above 12,000. Now there is some evidence that maybe we could well be starting to see a slight stalling of momentum and I don't think it's any coincidence that this stalling of momentum has occurred in the past week or so since Eurodollar may have found itself a little bit of a short-term base. Now we warned last week about a potential short squeeze in Eurodollar in the event the FOMC wasn't anywhere near as hawkish as we expected it to be and that has certainly turned out to be the case the fact of the matter is the Eurodollar was turning into very much a one-way trade and I think it was prudent to be cautious. So the big question now is where do we go here for the DAX and for the Eurodollar. Now if you buy into the narrative that the performance of the DAX is correlated to the weakness in the Eurodollar then further Eurodollar weakness should mean further DAX gains. Now some of the charts that I've been looking at over the course of the last week or so would appear to suggest that maybe the Eurodollar has found itself a short-term base. If that is in fact the case then we could find that the DAX could well top out and start to roll over and that wouldn't really be unexpected because if you look at where the DAX was at the beginning of this year it's put on 25%. So it's overdue a significant pullback, a significant correction. So certainly looking at the daily chart on the DAX there is some evidence of trend exhaustion. Let's look at Eurodollar to see whether or not there is a risk that we could actually see a move back above the peaks that we saw last week at one ten and a half and maybe a retest of one twelve and a half and maybe even further towards one fifteen. So let's look at our Eurodollar chart and let's play a little game here. Guess when the Fed announcement was. I don't think you'll need to look twice that massive spike towards one ten and a half before that correction lower. But what that spike has told us is that potentially we could have cleared out an awful lot of short positions and I think sentiment could be starting to shift just ever such a little bit because I think the focus now I think is on the US data and the likelihood or otherwise as to whether or not the Fed will look to tighten policy this year. The prospects of that have been pushed out. The big question is will the Fed tighten this year? If like me you think that prospect remains unlikely then there is certainly potential that maybe we've seen a low in Eurodollar thus far. Now on this four hour chart we do look incredibly overbought so I think there is potential for us to test back towards the 108 level and the trend line support from the lows on this chart here that we've drawn in from the middle of this month. We've also broken the trend line resistance from the December highs so certainly the sentiment is starting to shift a little bit but certainly not enough to suggest that we could not we probably might not get further pushes towards the downside to try and clear out any stay-alongs. At the moment the sentiment is starting to become slightly more uncertain in terms of the overall direction of Eurodollar but my bias is slightly shifting towards a much sharper short squeeze and I'll show you why in the context of this next chart. So this next chart is a weekly candlestick chart and I've highlighted the two candles in question that I want you to pay particular attention to. This is not quite a bullish engulfing week but it's certainly as close as it can be without actually being one. On the flip side of that we've got a similar looking candle on the dollar index, the weekly dollar index candle which does appear to suggest that potentially we may have seen a short-term peak in the dollar. So given how closely correlated these two markets are we do need to be cautious of further Euro dollar gains, further US dollar losses. Things get a little bit more interesting when you look at the monthly candle chart. Now we've got another week until month end so this candle is not fully formed but certainly if we remain at the levels that we're currently trading at right now then there is potential for a monthly hammer. Now hammer is a significant reversal pattern in candlestick charts so we need to pay particular attention to this candle because if it does post a hammer then there's a prospect, a significant prospect that we could well have put in a medium-term bottom and could actually potentially retest one 12.5 and maybe one 15 and one 20 over the course of the next five to six months. Let's also have a quick look at the client sentiment and we can see from the client sentiment that people still traders still want to sell the rally so that means for me the buyer still remains more to the upside than to the downside. Dips are more likely to be bought into so again that's another potential warning sign. So that's pretty much it for this week once again thanks very much for listening this is Michael Houston talking to you from CMC Markets.